text:
Round VS2 Clarity, I Color Diamond 14kt White Gold Earring Jackets (Fit 1.80 ctw - 2.00 ctw Round Studs)
Item #455574
Dress up your stud earrings and add extra sparkle with earring jackets. Diamond studs not included.
- Metal: 14kt White Gold
- Diamond Shape: Round Brilliant
- Total Diamond Weight: 0.80 ctw
- Total Number of Diamonds: 28
- Clarity: VS2 (Very Slightly Included)
- Color: I (Near Colorless)
- Size: Fit 2.00 ctw Round Studs
We guarantee that all diamonds supplied by Costco Wholesale are as follows: Clarity to be "VS2" or better and color to be "I" or better as outlined on the industry grading guide.
Diamond Color: Near Colorless (I)
Stone: Diamond
Stone Clarity: VS2
Total Carat Weight: 0.80
Type of Metal: 14kt White Gold
Two day air shipping via UPS insured is included in the quoted price. Signature is required. The estimated delivery time will be approximately 2-3 business days from the time of order.
Costco.com products can be returned to any of our more than 600 Costco warehouses worldwide.
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text:
Microsoft Releases IIS FastCGI Module 269
from the smells-like-coexistence dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
For one thing, Apache's FastCGI module is notoriously flaky and poorly documented. In the past, Apache users typically employed mod_php, mod_python, etc., and as a result mod_fastcgi has historically received second-class treatment by developers. There's a reason so many people are turning to lighttpd for their FastCGI applications even though Apache 2 offers its own multithreaded MPM, and performance is only part of the equation...
One thing I've been keeping an eye on is WPHP [pythonpaste.org]. It's only alpha-quality at the moment, but it's basically a WSGI application (WSGI is the standard Python web application interface) with a FastCGI backend that runs PHP. With something like this, you can mix and match PHP and Python — for example, you could write an authentication handler in Python and link it to a legacy PHP application.
The "free as in beer" thing really annoys me. I've NEVER seen free beer, anywhere! I propose we all stop using this ridiculous phrase and start using "free as in air" instead.
Now, if there IS free beer being offered somewhere, just point me in the right direction.
Try this direction:
http://en.wikipedia.org/wiki/Gratis_versus_Libre#Free_as_in_free_beer_versus_free_as_in_free_speech [wikipedia.org]
is this what you are looking for?
freebeer.org [freebeer.org]
The "free as in beer" thing really annoys me. I've NEVER seen free beer, anywhere!
Man, you are working for the wrong company and/or going to the wrong school.
Oh, and us travelling s/w folks can also write off the odd drink too. Consider a job in support, consulting, sales, product management or the executive team.
FastCGI is a good idea that's underutilized, underdocumented, and undermaintained. It's straightforward enough; the web server launches a subprocess, as with CGI, to handle the transaction. But instead of running it only once, the transaction process can be reused to process additional transactions. The web server and transaction process communicate via interprocess communication over local sockets. If the transaction process crashes, the server starts another one. Multiple transactions processes can be
An optimist believes we live in the best world possible; a pessimist fears this is true.

subset: commoncrawl


text:
God, Caesar and Zoning
Published: August 27, 2000
(Page 3 of 3)
''There are a lot of sentiments against Orthodox Jews that lie just below the surface,'' said Rabbi Reuven Fink of Young Israel. ''To me, that's the most painful aspect. We're always saying different things -- parking spaces, noise, aesthetics -- when we mean something else.''
Mr. Koplow, the former president of the congregation, said, ''You have to ask yourself whether the polite form of discrimination is better than people showing up and saying, 'Prevent the Brooklynization of New Rochelle' '' -- as one opponent did in 1994. ''At least you can address overt discrimination for what it is.''
Young Israel did itself no political favor by the manner in which it acquired the property in 1993. After the synagogue was rebuffed as a buyer, Mr. Koplow's sister-in-law purchased the house in her own name and then sold it to the congregation.
Rabbi Fink acknowledged the moral quandary involved in accepting this deal. ''This was a heart-wrenching decision for us,'' he said. ''We pride ourselves in being ethical. Meta-ethical. But we can't be nihilistic, either. If you're encountering bigotry and prejudice, every so often you have to counter it with a bit of ingenuity.''
Councilman Noam Bramson, a Democrat whose district includes the proposed synagogue site, said he did not doubt that ''some portion of the opposition is motivated by anti-Orthodox or anti-Semitic sentiment.
''But I think it's a distinct minority,'' he said. ''Most people who are concerned about the project are confining their objections to serious and legitimate land-use questions.
''As a general proposition, religious observance is an extremely important value,'' he said. ''And cities and towns ought to be welcoming to communities of faith. But I don't think it's an absolute value. Religious observance ought to be placed in the context of a wide variety of values, such as the character of neighborhoods, traffic management and environmental protection.''
The opponents, organized as Neighbors of New Rochelle, said in a flyer that the issue was solely one of ''converting an otherwise residential neighborhood into a commercial, heavily trafficked area,'' compromising public safety with the addition of hundreds of cars parking on surrounding streets.
What is sometimes lost in the debate, said leaders of Young Israel, is that all but one of its 240 families live within walking distance of the synagogue. It is currently housed in a 103-year-old former Methodist church at 1228 North Avenue, not far from the proposed building site, which the congregation acquired in 1967 and long ago outgrew.
''These are the neighborhoods in which we live,'' said Mr. Koplow, a partner in the law firm Wachtell, Lipton, Rosen & Katz, who was a key negotiator for the tobacco industry in its settlement talks with the state attorneys general. ''The idea that we would do anything that would destroy the value of our homes or the safety of our streets is incredible.''
The synagogue planned to furnish the required 120 parking spaces by purchasing part of an adjoining city-owned parcel. But in 1998, the city decided not to sell. ''At least a majority of the property was wetland,'' said Mayor Timothy C. Idoni. ''From an environmental standpoint, we've paved over way too much wetland.'' The mayor then tried to broker parking arrangements between Young Israel and Wykagyl Country Club next door or Christ United Methodist Church across the street, to no avail.
Last year, the congregation was notified that it would have to compile an environmental impact statement. ''We're not by any means trying to block the synagogue nor to destroy a neighborhood,'' said David H. Abrahams, chairman of the Zoning Board of Appeals of New Rochelle. ''We've determined that an E.I.S. is required because it's our belief that there will be a significant impact on the environment.''
Mr. Koplow described the scope of the impact statement as ''burdensome in the extreme,'' although the congregation prepared what turned out to be a 2 1/4-inch-thick document that even assesses prehistoric archaeological significance. ''How many people who are building a suburban building can tell you what happened on the site 14,000 years ago?'' Mr. Koplow asked.
New Rochelle's planning consultants, Ferrandino & Associates, have responded with 16 pages of comments and criticisms that Young Israel must address.
Once the environmental impact statement is certified as complete, the zoning board can take up the submission itself.
Designed by Graham Gund Architects of Cambridge, Mass., the building would have three parts. ''It helps break down the mass of the building into singular elements in scale with single-family homes,'' said John A. Prokos, a principal in the Gund office.
The most distinctive element, facing North Avenue, would be an octagonal study hall, or beit midrash, with a peaked roof. Along one side would be a narrow wing with offices and multipurpose rooms. At the back, under a gently bowed roof, would be the main sanctuary, with 607 seats, above the 5,688-square-foot social hall.
''We're talking about a social hall that would seat about 325 people and have a dance floor for line and ring dancing,'' Mr. Koplow said. ''The argument that this is somehow going to commercialize a residential neighborhood is a bit much.''
In trying to chart a fair course, Mr. Abrahams allowed that the zoning board would probably be portrayed as obstructionist by the synagogue and not tough enough by the neighborhood opponents. ''We have caught flak from both sides,'' he said, ''and I expect this is just the beginning.''
Photos: The Church of Jesus Christ of Latter-day Saints is seeking variances to build temple in Harrison, N.Y., to the ire of some neighbors. (Church of Jesus Christ of Latter-day Saints); Young Israel of New Rochelle, an Orthodox congregation, has met opposition in its effort to obtain zoning variances for a new synagogue, social hall and study hall, shown in the rendering above. It would replace the house at 1149 North Avenue, at left. (James Estrin/The New York Times); (Graham Gund Architects)(pg. 1); A 1993 religious land-use law was overturned by the Supreme Court in a case involving St. Peter Roman Catholic Church in Boerne, Tex., above. (Edward A. Ornelas for The New York Times)(pg. 4) Chart/Map: ''Zoning Rules and a Synagogue's Building Plans'' The map shows the site in New Rochelle, N.Y., where Young Israel of New Rochelle proposes a new synagogue. The diagram compares the existing and planned structures. AS IT IS NOW The 2 1/2-story frame house at 1149 North Avenue occupies a small portion of the 0.8-acre site. AS PROPOSED The 36,885-square foot Young Israel synagogue, study hall and social hall would have almost three times as much floor area as zoning rules allow. A variance is being sought.Source: Young Israel of New Rochelle Draft Environmental Impact Statement (Source: Young Israel of New Rochelle Draft Environmental Impact Statement)(pg. 4)


text:
Northwood High's girls track and field team moved closer to the first title in school history with an important win over Corona del Mar last week.
The Timberwolves defeated the Sea Kings, 70-57, at Corona del Mar.
Northwood improved its record to 5-0 in league dual meets.
Coach Louie Muniz called it "the best dual meet season in Northwood history."
The team will now shoot for a league title Friday night at league finals at University High.
"Finishing undefeated is a huge boost to the program and should help everyone perform well at league finals," Muniz said. "I don't think we have a weak event. We should get points from our distance girls led by Bethan (Knights) and from our sprinters and hurdlers, and freshman Kellie May has been a nice addition to the program in the jumps."
Muniz said Knights will triple in her events at league finals, competing in the 800 meters, 1,600 meters and 3,200 meters. She did the same and won all three events when Northwood edged Woodbridge in a dual meet earlier in the season.
"We are going to need as many points as we can," Muniz said. "We know Woodbridge is an excellent team. It is going to be a battle in event after event after event."
Northwood won 10 of 15 events against Corona del Mar to earn the win last week.
The Timberwolves got off to a great start. Northwood won the 4x100 relay in 51.2 and then swept the 1,600 meters.
Star Bethan Knights won in 5:07.3. Sami Murphy was second in 5:16.6, and Ashley Larson took third in 5:19.2.
Knights also won the 800 meters in 2:23.6 with Larson finishing second in 2:28.5.
Philine Qian was first in the 400 meters in 1:01.2, with Dani Solaru finishing second in 1:03.1.
Qian also led a sweep in the 200 meters. She won in 26.9. Chinye Chambers was second in 27.3, and Solaru took third in 27.4.
Northwood also swept the 100 meters. Carina Hendley (12.3) was first with Chambers (12.4) second and Eric Lu (13.0) in third.
Murphy won the 3,200 meters in 11:54.7 for the Timberwolves.
Kellie May won the long jump at 16-2 1/2 and the triple jump at 35-2 1/2 for Northwood.


text:
3 Young Golden Partridge Pekin roosters
PEKINS....... 3 young (4 months old) Gold Partridge Pekin roosters looking for new homes, starting to take shape and color, will be very nice birds when fully matured. Kept very clean and very well looked after £5 each. Good homes only please, delive
- DOB:01 Dec 2014
- Rehome date:26 Jan 2015


text:
"Addicted to Charlotte and Thomas books"
Davina Porter is an amazing narrator. In fact, she's the primary reason I can't get enough of the Pitt series on audio. Ms. Porter easily moves from one dialect to another, skillfully changing her voice from one gender and social class to another. It's her voice that makes me feel like I'm right there in London at the end of the 1800s.
I'm only disappointed that this is the last Pitt series book on Audible until later in the series.
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Outdoor Copper Planter..any advice??
I am a new homeowner and new to gardening.. I purchased a set of copper planters and then realized they may not be the best for our HOT Oklahoma summers! :( I really like them and still would like to use them on my patio and in the entry of my home.
The largest measures W20.75" x D20.75"
I will be shopping for Spring plants soon and would like to plant some type of a Cordyline with Sweet Potato Vine in the large planter, which would be sitting on the corner of our garage, on top of pavers surrounded by rocks. I have a few questions before I do this...
-The planter does not have drainage holes. Would putting pebbles on the bottom be enough not to drown my plants or should I drill a hole? Or would either method be okay?
-Would the metal planter fry my plants in our heat..?
-Can I line the planter with a black garbage bag so that the roots are not touching the copper..?
Anyone have experience with metal planters??
Any advice would be greatly appreciated!!


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You can now invite anyone to meet at your favorite Starbucks.
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54 year old man | Etobicoke, ON, CAN | Seeking women 41-55 within 25 miles
Active within 24 hours
I hate to be predictable. I like...
I hate to be predictable. I like spontaneity.....especially if it's well planned. I enjoy conversation, Sunday mornings, evenings with a glass (or two) of wine, fresh air, music and the pursuit of happiness! I like the city but prefer weekend getaways, up north, on the boat, on the dock, in front of a fire. I like sunsets, beaches, tequila, loud music and the Maple Leafs (bite your tongue). I'm active and healthy but not religious about it. I don't take things too seriously. I don't take myself too seriously. But when the situation calls for it, I'm there. I do the right thing. 3 questions...... .........do you believe in rock and roll? ....................can music save your mortal soul? .................................and can you teach me how to dance real slow?
Camping , Coffee and conversation , Dining out , Movies/Videos , Music and concerts , Nightclubs/Dancing , Volunteering , Wine tasting
Billiards / Pool, Cycling, Dancing, Inline skating, Other types of exercise, Running, Skiing, Walking / Hiking
I exercise 1-2 times per week.
I have Dogs
I like Birds, Cats, Horses
the sun.
um, i like music, blading, the cottage, wine, weekend getaways, snow skiing, water skiing, Sunday mornings, live bands, the pursuit of happiness and.......patio season!!
reading??? who's got time to read? I recently read "The Kite Runner" and "The Last Lecture". I also read my niece a bedtime story. it worked. we both fell asleep. OK, dirty little secret, I loved & hated (mostly loved) Motley Crue's "The Dirt".
Z{{Cta}} {{#if HasMoreInfo}} ?{{CtaSecondary}} {{/if}}
|What he is looking for
|5'8" (173cms)
|5'0" (152cms) to 5'5" (165cms)
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i work. i play. i live for the weekend. i can't even spell stress.
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text:
Originally written on The Flagrant Fan | Last updated 11/18/14
Dewayne Wise has now pitched twice this season. While that is already unusual for a position player, doing so for two different teams is even more unusual. And the funniest part of such occurrances is that they completely baffles PITCHf/x. Here's how: If you go to Wise's Fangraphs.com page, you can click on his pitching statistics They show that in two appearances on the mound, Wise has pitched one and two-thirds innings. He has allowed no runs with one hit and one walk allowed. His ERA, of course, is zero, but his FIP is 4.91. Those are all easy to verify in cement. But PITCHf/x had trouble figuring out what he was throwing. According to Fangraphs' own data, Wise threw 85.7 percent fastballs and 14.3 percent change ups. The site also lists the data from PITCHf/x and that data says that Wise has thrown 5.3 percent fastballs and 94.7 percent change ups. This writer is not sure what you think of such things, but this observer finds that data discord hilarious. ...
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Hampton eNewsletter
Sign up and get Hampton events, news and promotions delivered to your inbox.
From a distance, dramatic white peaks suspended above the entrance to the Hampton Roads Convention Center resemble the billowing sails of an elegant ship racing across the sea. It's an evocative visual reference to Hampton's historic maritime heritage, one that reaches back more than 400 years to our nation's first settlement.
History meets high technology with impressive results in the Hampton Roads Convention Center. With 344,000 total square feet of versatile convention and exhibit space, 35 flexible spaces for up to 14,000 delegates and a grand ballroom with banquet seating for more than 2,000, this flexible modern meeting facility in Hampton, Virginia, was designed to host an array of meetings, conventions and exhibitions.
04/02 Tastefully Yours 2015 presented by the Food Bank of the Virginia Peninsula
04/04 Little Heroes at Home- Celebration of the Military Child
04/10 Virginia/North Carolina Golden Gloves Championships (April 10-12)
04/11 Virginia Hot Rod & Custom Car Show (April 11-12)
04/23 Boo Williams NIKE Spring Girls Basketball Invitational (April 23-26)


text:
- Exchange: New York
- Sector: Energy
- Industry: Oil, Gas & Coal
- Sub-Industry: Exploration & Production
Penn Virginia Corp+ Add to Watchlist
As of 18:40:02 ET on 03/26/2015.
Company Profile for Penn Virginia Corp (PVA)
Penn Virginia Corporation explores for and produces oil and natural gas. The Company also collects royalties and overriding royalty interests on various oil and gas properties, coal mineral rights, and related royalties. Penn explores for crude oil and condensate and natural gas in the Appalachian Basin. The Company operates in VA, WV, and KY.
Contact Information
Penn Virginia Corp
Key Executives for Penn Virginia Corp (PVA)
|H Baird WhiteheadPresident/CEO
|Nancy M SnyderExec VP/CAO/Secy/Gen Counsel
|John A BrooksExec VP/COO
|Steven A Hartman "Steve"Senior VP/CFO
|Michael E StamperVP/Regional Manager
|Joan C SonnenVP/Chief Acctg Officer
Quotes delayed, except where indicated otherwise. All prices in local currency. Time is ET.


text:
12 Sky Hollow Drive
Commute to Downtown Albany
Almost all errands require a car.
Score Details
12 Sky Hollow Drive has a Walk Score of 14 out of 100. This location is a Car-Dependent neighborhood so almost all errands require a car.
The closest park is Hackett Park.
Nearby schools include Menands School, Loudonville Christian School and North Albany Academy.
The closest grocery store is Genoa Importing Co.
Nearby coffee shops include Broadway Business Center and Peppy D's Cafe. Nearby restaurants include Sun Fai, Sun Fai and KFC Albany.
Explore how far you can travel by car, bus, bike and foot from 12 Sky Hollow Drive.
Bus lines:
182 Troy-Albany via Cohoes/Latham
0.1 mi
22 Albany - Troy via Watervliet
0.7 mi


text:
26 Mar 2015
Agricultural Enlightenment et circulation des savoirs entre la Grande-Bretagne et les pays d'Europe, 1760-1820
Peter Jones (Birmingham)
10 Mar 2015
Portugal on the periphery? Scenarios from the History of Sexuality, 1900-1960
Richard Cleminson (Leeds)
24 Feb 2015
Tracking the Emergence of New Words across Time and Space
Jack Grieve (Aston)
23 Feb 2015
Therapeutic Leisure in Victorian Britain
Charlotte Jones (University College London), Dr Jade Shephard (Queen Mary University of London)
17 Feb 2015
Sex backwards. Sexology speaks about desire in communist Czechoslovakia
Kateřina Lišková (Masaryk University)
17 Feb 2015
Company numbers: a key resource in tracing businesses and their records
Alex Ritchie (The National Archives)
5 Feb 2015
Writing a Writer (Autour d'un ècrivain): Joseph Woolley, Sir Gervase Clifton, and the Law
Carolyn Steedman (Warwick)
2 Feb 2015
Saving Winchester: Voluntary Societies, Historic Buildings and Urban Redevelopment
Michael Nelles (University of Southampton)
29 Jan 2015
"On British felony, the sun never sets": Australian convict narratives, 1788 to 1868
Dr Tim Causer (University College London)
19 Jan 2015
The Making Of A Social Researcher
Dr Duncan Scott (Independent Scholar)
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text:
Harkin, Enzi Applaud Passage of Bipartisan Food and Drug Administration Safety and Innovation Act
Lifesaving Legislation Now Goes to President Obama for His Signature
Tuesday, June 26, 2012
WASHINGTON—Today, Senator Tom Harkin (D-IA) and Senator Mike Enzi (R-WY), Chairman and Ranking Member of the Senate Health, Education, Labor and Pensions Committee, heralded final passage of the Food and Drug Administration Safety and Innovation Act (S.3187), bipartisan HELP Committee legislation that would ensure that the FDA can approve drugs and medical devices, save biomedical industry jobs, protect patient access to new therapies, and preserve America's global leadership in biomedical innovation. The legislation, which was approved by the Senate by a vote of 92 to 4, now goes to President Obama for his signature. Senators Harkin and Enzi made the following joint statement after the vote:
"Approval of the Food and Drug Administration Safety and Innovation Act is the result of nearly two years of bipartisan cooperation and hard work. This bill is a great example of the kind of progress we can achieve when we work together, and we are grateful to all of our colleagues for their efforts in this process. This legislation will help bring critical drugs and medical devices to market faster, protect patients from drug shortages and manufacturing problems, and enhance the availability of low-cost generic drugs. It will also help patients with rare and very rare diseases obtain access to effective therapies more rapidly. It will help the FDA do its job more effectively, increasing accountability and transparency, so U.S. companies can innovate and compete in the global marketplace.
"While people like to talk about polarization and gridlock in Washington, this bill is a victory for both bipartisanship and for the millions of American who rely on medicines and medical devices."
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On our way home
... Jamie's italian for dinner. We started with a cured meats platter which unfortunately was not that great. But in saying that, we just came from Europe where cured meats are their specialty. For dinner I got a linguine in a tomato sauce and prawns and Jordan got a burger. They were very nice. After dinner we went back to the White cross for one more and made our way back for an early night. As most of you know, we had issues with our flights so we have now been travelling for ...
Start of the adventure
... bit to surprise the lodger and grab a bottle of wine before switching the tv on. However the backpack has been checked in and reality will kick in soon enough of the hugeness of what I'm going to be doing. Countries that I've read about, Indonesia, New Zealand, USA... they're all out there and two sayings come to mind: life is for living and you only live ...
Monday 2nd Feb This is our first adventure into the unknown, something everybody should do before they're 100! It all started with a casual glance in a Travel Agent's window by Jennifer last year. Packing now complete and 'checked in' on line we're ready for the off tomorrow - stay ...
A cold snap here and the forecast for my trip looks to be a week of top temperatures -1 and lows of -22 degC.... Wow that'll be interesting.. Bought some necessary stuff today, thermals and boots.... Had an afternoon investigating Boston, Washington and Brooklyn for a trip.. Settled on Brooklyn and looks like some interesting things to ...
Happy Christmas and thank you
Well I have been back for over a week now. This extraordinary experience is beginning to fade now I am in this new chapter.
I am so grateful and humbled by the whole experience. As I spend Christmas with cherished friends and dear family, I realise just how lucky I am.
The support I have had from really wonderful people who are kind and caring also humbles me. This entry is for them to say a huge THANK YOU.


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Book your room at Econo Lodge
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La Junta hotel with an indoor pool
Situated in La Junta, this hotel is in the same region as Bent's Old Fort National Historic Site, Rocky Ford Museum, and Rocky Ford City Hall. Regional attractions also include Rocky Ford Country Club.
Hotel Features
Recreational amenities at Econo Lodge include an indoor pool and a spa tub. Other amenities include complimentary wireless Internet access and free self parking.
Room Amenities
In addition to complimentary wireless Internet access and refrigerators, guestrooms feature microwaves along with climate control and coffee/tea makers.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Econo Lodge features an indoor pool and a spa tub. Public areas are equipped with complimentary high-speed wireless Internet access. A complimentary breakfast is offered. This La Junta hotel also offers complimentary newspapers in the lobby, a television in the lobby, and RV/bus/truck parking. Onsite self parking is complimentary.
Econo Lodge is a smoke-free property.
- Total number of rooms - 39
- Number of floors - 2
- Free newspapers in lobby
- Free breakfast
- Designated smoking areas
- Free WiFi
- Designated smoking areas (fines apply)
- RV, bus, truck parking
- Free self parking
- Smoke-free property
- Spa tub
- Indoor pool
- Television in lobby
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking, RV, bus, truck parking
Room Amenities
- Climate control
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- Free WiFi
Where to Eat
Guests are offered a complimentary continental breakfast.
Nearby Things to Do
An indoor pool and a spa tub are on site.
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
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Minimum check-in age is 21
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- Late check-out fee: USD 50.00
- Deposit: USD 50.00 per stay (cash only)


text: Quick View Mosasaurus: Mighty Ruler of the Sea by Karen Wagner May 1, 2008 | Trade Paperback Out of stock online used copies from $9.18 The prehistoric sea can be a dangerous place, even for an enormous creature like Mosasaurus. Will Mosasaurus make his way through the water safely and find himself a tasty snack? Kids are bound to love this book with its detailed illustrations and storyline that has been reviewed by… See Details $7.95 / $7.55 lowest price*, or used from $9.18was $7.95


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The episode starts off with the Colonel breaking the gang up into two seperate teams with the teams goal to build a model rocket ship. First prize is the ship that gets the farthest off the ground. As usual Screech and Belding are on opposite teams so the constant annoying bickering back and forth over whos ship is better got repetitive and painstaking quick. Also joining the teams were two girls from the hit NBC Saturday morning show "Hang Time." I especially liked the crossover because it was rarely done back then. The hotter of the two (Mary-Beth) IMO gets paired up with Ryan. They take Beldings car to get supplies and it breaks down. While Ryan works on the car he takes a small break to gaze at the stars with Mary-Beth which at that point you knew a kiss was coming and BAM it happened. Unfortunately both of them are in their own relationships. Ryan goes to Nicky for advice on how and if he should tell Rachel and Nicky tells him to do it. Ryan sits Rachel down and explains to her that it was a meaningless kiss that meant nothing and shes the one he really cares about. It seemed like she wanted to badly believe that he was telling the truth but couldnt fully fall for it. It wasnt until Mary-Beth goes into Rachels room and has a one on one chat with her about how Ryan really does care about her and hearing that from the girl who cheating on your boyfriend with mustve meant a lot cause she decided to give Ryan another shot.
Back to the wack ass Belding/Screech rocket fiasco. After them trying to outdo each other it eventually got to the point where they ripped each others model ships apart into pieces, basiaclly ruining the excersise. All is well though in Saved By The Bell Land though as a last minute idea thought of by Belding is for both teams to combine and make one ultimate model rocket ship to which everyone obliges. With ten minutes before the ships take off, Screech is prepping the crew on which buttons not to push, etc. It doesnt take a rocket scientest to figure out that the f'n douchebag was going to press the wrong button thus having the ship take off in the middle of the classroom causing massive chaos which then lead to the end credits.moreless


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SYNOPSIS: A cop on the verge is sent to his small hometown to shape up. When a girl no one cares about goes missing, his slow recovery ends abruptly. REVIEW: The Last Harbor is a somewhat simple but well thought murder mystery about an alcoholic detective transferred to a harbor town sometime after the disappearance of the local prostitute. This 2010 film was produced by independent companies Media 8 entertainment and Entertainment Motion Pictures at … Continue reading
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SYNOPSIS: After a tragic act of violence cuts short her music career, Kate Stone is returning to a city full of ex-fans and ex-friends. Taking shelter with her last friend, a struggling artist named Robyn Huck, the two women work to restore the aging courtyard apartment building Robyn has inherited. But a terrible secret infests the venerable structure, and soon Kate will be haunted by horrific dreams, sinister apparitions, and the sounds of something moving … Continue reading


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Recent answers to Connecting in spite of bad security certificatehttps://support.mozilla.org/en-US/questions/9492952013-02-05T08:06:10-08:00You should always be cautious and never set a permanent exception in cases like this. You can get su2013-02-05T08:06:10-08:00cor-elhttps://support.mozilla.org/en-US/questions/949295#answer-404937
You should always be cautious and never set a permanent exception in cases like this.

You can get such errors if a website doesn't send all intermediate chain certificates.

You can retrieve the certificate and check who issued the certificate.
 You should always do that to see if that helps to identify the problem (missing intermediate certificate or something else).
 You can test a website via one of the SSL checking websites.

http://www.networking4all.com/en/support/tools/site+check/

If such a check confirms that there is a problem with the certificate then you know that you do not have to look further.

Check out why the site is untrusted (see the Technical details) and if this is caused by a missing intermediate certificate then see if you can install this intermediate certificate from another source like the above posted testing site.

You can retrieve the certificate and check details like who issued certificates and expiration dates of certificates.

Click the link at the bottom of the error page: "I Understand the Risks"

Let Firefox retrieve the certificate: "Add Exception" -> "Get Certificate".

Click the "View..." button and inspect the certificate and check who is the issuer.

You can see more Details like intermediate certificates that are used in the Details pane.
Thanks, yalam96. I actually meant what you said i.e. the things you don't care to encrypt excludes 2013-02-04T22:28:20-08:00FoxyFireyhttps://support.mozilla.org/en-US/questions/949295#answer-404845
Thanks, yalam96. I actually meant what you said i.e. the things you don't care to encrypt excludes authentication info. I just wrote it in a confusing way :) .
Almost correct. Authenticating would be no exception with an untrusted connection. On an untrusted c2013-02-04T12:41:49-08:00yalam96https://support.mozilla.org/en-US/questions/949295#answer-404744
Almost correct.

Authenticating would be no exception with an untrusted connection. On an untrusted connection, everything you do should be considered at risk, including authentication.


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text:
League of Legends
Flash + TP Leona new meta
So basically just play Leona completely normally but instead of ganking normally whenever it's safe and taking an extra CC, you take teleport and get maybe one extra surprising gank every 5 mins or so without exhaust.
Overused memes disqualify you from conversing with me.
ritz2 posted...
Silvanus350 posted...Why is everyone complaining so much?
That is why, as I said, you see if there is an opportunity to teleport only after getting a kill...
You are now breathing manually.
[[[[[[[[[[[[[[[[[ ~ |||||||||||||||||||| ~ ]]]]]]]]]]]]]]]]]
Silvanus350 posted...
ritz2 posted...Silvanus350 posted...Why is everyone complaining so much?
give me an example situation
Teleport on leona is pretty good
Halo4 is a gothamcityimpostors clone, which is not a good thing at all
Anarchy Reigns is coming for 30 bucks, get hype!
I don't see what's special about it, you just play normally, and take teleport instead of flash.
You chill in lane looking for an opportunity. The enemy ADC overextends and you jump on him, pop your combo, get a kill. The enemy support is now alone and probably beating a retreat.
You swing into the bushes and check toplane. If it looks good you teleport top and pop your combo again, hopefully getting another kill. It's 1v1 bot lane until the enemy revives, and they might not even know you're gone until you TP, if the bush isn't warded.
You are now breathing manually.
[[[[[[[[[[[[[[[[[ ~ |||||||||||||||||||| ~ ]]]]]]]]]]]]]]]]]
ITT: Teleport has no animation.
Noblesse Oblige May you go on and conduct in a honorable manor.
Noblesse_ posted...
ITT: Teleport has no animation.
ITP: Wards hidden in unwarded brush don't exist
Overused memes disqualify you from conversing with me.
k0rupted1 posted...
BowtotheTWIG posted...Your AD then dies / gets completed zoned in the ensuing 2v1 lane
Question, how did world trade center building 7 (the -3rd- building to fall) collapse during 9/11? http://www.youtube.com/watch?v=nnnjIzamnJo
k0rupted1 posted...
BowtotheTWIG posted...Your AD then dies / gets completed zoned in the ensuing 2v1 lane
LoL uses a ranking system, even in unranked, so odds are even that your partner will be either superior or inferior to the two you're laning against.
If you've played for long, you know that two players of relatively equivalent skill can easily zone a single opponent, no matter the champ.
I think bottom lane would be lucky if AD only got zoned instead of killed. It might be best for bottom to push hard before Leona TPs and then have the AD just go back and buy.
Paid DLC at release = end of games.
I wish people who come up with stupid ideas would quit calling them "new meta" and actually learn what that means. Santa give what I want this year, pleaseee.
"I read this as a Bannanable Offense. I was like, what ksing with Soraka?"-Kirby 1207


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Buick Skylark Questions Maintenance & Repair
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missing a body part and need to know the name; what is the body part called that fits on the body filling in the gap by the rear bumper?
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My airbags deployed when I was only going 12 miles an hour and now I can't sell it until I have airbags. I don't want to scrap the car because I have replaced the majority of the things in it.
Engine Knocking
when i rev up my car i can hear a loud knocking when the car is in idle you cant hear the noise only when i rev it up any help thanks
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Whenits cold it will start right up but when I drive it after putting gas in when I shut it off it wont start until cool. No check engine ligths are on.
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I'm looking for a replacement of my pulse board module. GM sent me the wiper motor - new; but no pulse board. Can anyone help me?
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i just got a 94 buick skylark that has hit two deer and been in a ditch i need a grill passenger side fender drivers side headlight and side light and they are hard to find used in ths area of spokane...
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We have changed fuel filter, air filter, plugs, coil packs, nothing helps. It has about 50k miles, 4 cyl engine. Also seems to be getting less gas mileage than normal.
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when i start up 98 skylark, all dash lights and gauges stay on, and temp gauge quits working after car running for a few minutes. also, alternator putting out 15-16 volts??? the car was front end da...
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3 Radio Stations from Andira
Rádio T (Andirá) - 97.5 FM
Brazilian Pop Portuguese Top 40
Andira, Brazil
Rádio Vida FM
Christian Education Gospel Talk
Andira, Brazil
Radio Mult Farma
Brazilian Hits Music
Andira, Brazil
Listen to radio stations from Andira, from a wide variety of genres like Brazilian, Christian, Hits, Pop and Portuguese. Enjoy stations such as Rádio T (Andirá) - 97.5 FM, Rádio Vida FM, Radio Mult Farma and more. Come find the top new songs, playlists, and music! Listen on your iPhone, iPad, iPod Touch, Android, Blackberry, and other app-enabled mobile phones.


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OMAN -- Oman Oil plans to enter the Chilean natural gas market in partnership with Enagas.
The Middle Eastern company, which has held a 5% stake in Enagas since 2009, will buy a stake in GNL Quintero, the operator of a LNG re-gasification terminal in central Chile, from Enagas, a person in the industry said. The venture in Chile would be Oman Oil's first step in Latin America.
Enagas bought a 20% stake in GNL Quintero from BG in 2012 and plans to acquire another 20% in the coming months. The other shareholders in the LNG venture are state oil company Enap, , Empresa Nacional de Electricidad, and Chilean gas distributor Metrogas, each with a 20% stake.
A report in local newspaper El Mercurio said that Oman Oil would buy 20% of GNL Quintero from Enagas.
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Think It, Ink It, Do It, Review It.
The story of Humpty Dumpty was first printed in 1810 and became famous through Lewis Caroll's book, 'Alice Through the Looking Glass'. It's one of those unforgettable nursery rhymes, and perhaps …continues
Standing Out from the Crowd
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Finish It Out Strong!
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The East Washington Township police officer and veterinarian was shot during a traffic stop.
Photos: Funeral for Officer John David DryerUPDATED 3:02 PM EST Dec 23, 2011
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Simple, Mind Expanding Transcription Project
Closed - This job posting has been filled.
Job Description
Simple interview with two parties sharing secrets of life, death, and the universe.
Will start with two 1 hour interviews, for a total of 2 hours needing to be transcribed, and must remain confidential and not shared with others.
There are several more needing to be transcribed. Just want to ensure you are capable of delivering quality work prior to hiring you for other interviews and transcription needs.


text:
|Coast Guard Approved:
|Non Coast Guard Approved
|Closure System:
|Side Zip
|Recommended Use:
|Watersking, Wakeboarding
|Manufacturer Warranty:
|1 Year
Description: Jet Pilot OG Comp Wakeboard Vest
With designing and testing done by Shane Bonify, it should be no surprise that the Jet Pilot OG Comp Wakeboard Vest is a truly amazing product. For starters, the Neoprene material makes for a lightweight yet reliable and durable vest without any sacrifices. It also remains plenty flexible and comfortable, especially with details like an elastic cinch cord waist and side zip that make this vest perfect for any serious wakeboarder out there.
Key Features of the Jet Pilot OG Comp Wakeboard Vest:
- Designed and Tested by Shane Bonifay
- All 1mm Neoprene
- Unmatched Stretch for Comfort and Performance
- Elastic Cinch Cord Waist
- Cuts Wind Chill
- Screen Printed Logos
- Sublimated Graphics
OG Comp
4.0 / 5.0
2 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
Best vest in the west
Fits good,floats decent,looks ,west side riders style for the ogs
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November 10, 2014
9 months ago
9 months ago
Jet Pilot OG Comp Wakeboard Vest
It is a great product for a Great price. I would recommend this Vest to anyone who enjoys water sports. Very comfortable.
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text:
I have a method called is_following in the user.rb model, and it checks to see if one user is following another.
Users Controller
def show
@user = User.find(params[:id])
respond_to |format|
format.json { render json: @user, :methods => [:image_url, :is_following] }
User Model
def is_following params
return "yep" if params[:follower_id] == id
However, I don't know how to pass params into the :is_following method in the controller. Anyone have any luck or solution to this?


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text: Rob talks moving past Twilight in "The Rover" interview with First Class News [Cannes 2014] Posted on 05/19/2014 by Kelsey · Leave a comment Plus Guy says some really sweet stuff about how talented Rob is! I mean…that's not news to us Source: YouTube / rpattzclub Share this:Share on TumblrPrint Popular Posts & Pages ***SPOILER ALERT*** Camp X-Ray Jennifer Lawrence Mentions Kristen in Marie Claire (June issue) FanFic Favs HOT SEXY Robsten Video! Kristen Stewart's Playlist Picks!


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Westview is a populated place located in St. Clair County at latitude 38.537 and longitude -90.102.
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text: Business Process Reengineering Jobs 3 were found based on your criteria Post a job. It's free! It Application Design and Development Proposal Fixed-Price – Est. Budget: $500.00 Posted March 9 2015 I need to a technical proposal writing for a client of mine. They would like to create a new survey product which will allow opticians to survey their clients. Each optician will have secure access to their own area where they can: - Create a new survey based on questions they create themselves - Select participants - Schedule the survey - Maintain existing surveys - Analyse survey results on a dashboard There will be a top level admin system where administrators can create generic questions ... business-process-reengineering Affordable offshore biz manager, unlimited hours. Hourly – More than 6 months – 30+ hrs/week – Posted Feb. 27 2015 Affordable offshore biz manager, unlimited hours. Rate must be SUPER LOW. under 3.34. Requirement: Flawless native english slang style high bandwidth skype good availability to get some work done affordable affordable affordable rate We have: many bonus upon performance endless unlimited workload ahead be your own boss business-development business-intelligence business-management business-models business-plans business-process-modelling business-process-reengineering Business Process Designer Hourly – Less than 1 month – 30+ hrs/week – Posted Feb. 15 2015 ABOUT THE JOB Do you live and breathe process design? Do you love taking unorganized tasks and simplifying them into efficient and easy-to-understand processes? Then we should talk. We are looking for a super passionate and talented process designer to help us turn complex workflows and ideas into effective processes that save us time, headache and money. We need someone who is experienced in process design, dependable and readily available to work. Experience in creating visual processes is a major ... business-process-modelling business-process-reengineering process-architect process-improvement


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lortab percoset
Where can I get pain meds without a script?
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- lortab, lortab 10/500, pain
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Answers (1)
16 Nov 2009
You will see stuff advertised on the internet, but, the feds and the US customs agents are really cracking down on that type of trade. My old boss had been ordering prescrition diet pills and all of a sudden, he got a letter from the US Customs saying they had seized his last order and they threatened to prosecute him. Be very careful. Not to mention the fact that the company could just take your money, and you won't be able to complain because your order was illegal.
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text: Stem Cell Research & Therapy - Latest Articles http://stemcellres.com The latest research articles published by Stem Cell Research & Therapy 2015-03-26T00:00:00Z Acyclic retinoid induces differentiation and apoptosis of murine hepatic stem cells IntroductionTherapeutic potential of acyclic retinoid (ACR), a synthetic retinoid, has been confirmed in experimental and clinical studies. Therapeutic targets include precancerous and cancer stem cells. As ACR is also involved in developmental processes, its effect on normal hepatic stem cells (HpSCs) should be investigated for understanding the underlying mechanisms. Here, we examined effects of the acyclic retinoid peretinoin on fresh isolated murine HpSCs. Methods: We isolated c-kit−CD29+CD49f+/lowCD45−Ter119− cells from murine fetal livers using flow cytometry. To evaluate the effect of ACR, we traced clonal expansion and analyzed cell differentiation as well as apoptosis during the induction process by immunofluorescent staining and marker gene expression. Results: ACR dose-dependently inhibited HpSCs expansion. Stem cell clonal expansion was markedly inhibited during the culture period. Moreover, ACR showed a significant promotion of HpSC differentiation and induction of cellular apoptosis. The expression of stem cell marker genes, Afp, Cd44, and Dlk, was downregulated, while that of mature hepatocyte genes, Alb and Tat, and apoptosis-related genes, Annexin V and Caspase-3, were upregulated. Flow cytometry showed that the proportion of Annexin V-positive cells increased after ACR incubation compared with the control. Data obtained by immunofluorescent staining for albumin and Caspase-3 corroborated the data on gene expression. Finally, we found that ACR directly regulates the expression of retinoic acid receptors and retinoid X receptors. Conclusions: These findings indicate that ACR inhibits the clonal expansion of normal HpSCs in vitro and promotes the differentiation of immature cells by regulating receptors of retinoic acid. http://stemcellres.com/content/6/1/51 Hong-Bin Guan Yun-Zhong Nie Yun-Wen Zheng Kazuya Takiguchi Hong-Wei Yu Ran-Ran Zhang Bin Li Tomonori Tsuchida Hideki Taniguchi Stem Cell Research & Therapy 2015, null:51 2015-03-26T00:00:00Z doi:10.1186/s13287-015-0046-9 /content/figures/s13287-015-0046-9-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 51 2015-03-26T00:00:00Z PDF Human umbilical cord blood-derived mononuclear cells improve murine ventricular function upon intramyocardial delivery in right ventricular chronic pressure overload IntroductionStem cell therapy has emerged as potential therapeutic strategy for damaged heart muscles. Umbilical cord blood (UCB) cells are the most prevalent stem cell source available, yet have not been fully tested in cardiac regeneration. Herein, studies were performed to evaluate the cardiovascular safety and beneficial effect of mononuclear cells (MNCs) isolated from human umbilical cord blood upon intramyocardial delivery in a murine model of right ventricle (RV) heart failure due to pressure overload. Methods: UCB-derived MNCs were delivered into the myocardium of a diseased RV cardiac model. Pulmonary artery banding (PAB) was used to produce pressure overload in athymic nude mice that were then injected intramyocardially with UCB-MNCs (0.4 x 10^6 cells/heart). Cardiac functions were then monitored by telemetry, echocardiography, magnetic resonance imaging (MRI) and pathologic analysis of heart samples to determine the ability for cell-based repair. Results: The cardio-toxicity studies provided evidence that UCB cell transplantation has a safe therapeutic window between 0.4-0.8 million cells/heart without altering QT or ST-segments or the morphology of electrocardiograph waves. The PAB cohort demonstrated significant changes in RV chamber dilation and functional defects consistent with severe pressure overload. Using cardiac MRI analysis, UCB-MNC transplantation in the setting of PAB demonstrated an improvement in RV structure and function in this surgical mouse model. The RV volume load in PAB-only mice was 24.09 ± 3.9 compared to 11.05 ± 2.09 in the cell group (mm3, p-value < 0.005). The analysis of pathogenic gene expression (BNP, ANP, Acta1, Myh7) in the cell-transplanted group showed a significant reversal with respect to the diseased PAB mice with a robust increase in cardiac progenitor gene expression such as GATA4, Kdr, Mef2c and Nkx2.5. Histological analysis indicated significant fibrosis in the RV in response to PAB that was reduced following UCB-MNC's transplantation along with concomitant increased Ki-67 expression and CD31 positive vessels as a marker of angiogenesis within the myocardium. Conclusion: These findings indicate that human UCB-derived MNCs promote an adaptive regenerative response in the right ventricle upon intramyocardial transplantation in the setting of chronic pressure overload heart failure. http://stemcellres.com/content/6/1/50 Saji Oommen Satsuki Yamada Susana Peral Katherine Campbell Elizabeth S.Bruinsma Andre Terzic Timothy Nelson Stem Cell Research & Therapy 2015, null:50 2015-03-26T00:00:00Z doi:10.1186/s13287-015-0044-y /content/figures/s13287-015-0044-y-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 50 2015-03-26T00:00:00Z PDF Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities IntroductionChimeric mice with humanized livers were recently established by transplanting human hepatocytes. This mouse model that is repopulated with functional human hepatocytes could be a useful tool for investigating human hepatic cell biology and drug metabolism and for other preclinical applications. Successfully transplanting human hepatocytes into mice requires that recipient mice with liver failure do not reject these human cells and provide a suitable microenvironment (supportive niche) to promote human donor cell expansion and differentiation. To overcome the limitations of current mouse models, we used Alb-TRECK/SCID (TRECK: Toxin Receptor Mediated Cell Knockout) mice for in vivo human immature hepatocyte differentiation and humanized liver generation. Methods: 1.5 μg/kg diphtheria toxin (DT) was administrated into 8-week-old Alb-TRECK/SCID mice, and the degree of liver damage was assessed by serum aspartate aminotransferase (AST) activity levels. Forty-eight hours later, mice livers were sampled for histological analyses, and the human donor cells were then transplanted into mice livers on the same day. Chimeric rate and survival rate after cell transplantation was evaluated. Expressions of human hepatic related genes were detected. A human albumin ELISA was done after 50 days of transplantation. On day 60 after transplantation, drug metabolism was examined in mice. Results: Both human primary fetal liver cells (FLCs) and hepatic stem cells (HpSCs) were successfully repopulated in the livers of Alb-TRECK/SCID mice that developed lethal fulminant hepatic failure after administering DT; the repopulation rate in some mice was nearly 100%. Compared with human primary FLCs, human HpSCs transplantation rescued Alb-TRECK/SCID mice with lethal fulminant hepatic failure, and human HpSCs-derived humanized livers secreted more human albumin (ALB) into mouse sera and also functioned as a "human liver" that could metabolize the drugs ketoprofen and debrisoquine. Conclusion: Our model of a humanized liver in Alb-TRECK/SCID mice may provide for functional applications such as drug metabolism, drug to drug interactions, and promote other in vivo and in vitro studies. http://stemcellres.com/content/6/1/49 Ran-Ran Zhang Yun-Wen Zheng Bin Li Tomonori Tsuchida Yasuharu Ueno Yun-Zhong Nie Hideki Taniguchi Stem Cell Research & Therapy 2015, null:49 2015-03-26T00:00:00Z doi:10.1186/s13287-015-0038-9 /content/figures/s13287-015-0038-9-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 49 2015-03-26T00:00:00Z PDF Nuclear reprogramming with a non-integrating human RNA virus IntroductionAdvances in the field of stem cells have led to novel avenues for generating induced pluripotent stem cells (iPSCs) from differentiated somatic cells. iPSCs are typically obtained by the introduction of the four factors OCT4, SOX2, KLF4, and cMYC, via integrating vectors. Here, we report the feasibility of a novel reprogramming process based on vectors derived from the non-integrating vaccine strain of measles virus (MV). Methods: We produced a one-cycle MV vector by substituting the viral attachment protein gene with the green fluorescent protein (GFP) gene. This vector was further engineered to encode for OCT4 in an additional transcription unit. Results: After verification of OCT4 expression, we assessed the ability of iPSC reprogramming. The reprogramming vector cocktail with the OCT4-expressing MV vector and SOX2-, KLF4- and cMYC-expressing lentiviral vectors efficiently transduced human skin fibroblasts and formed iPSC colonies. RT-PCR and immunostaining confirmed induction of endogenous pluripotency-associated marker genes, such as SSEA4, TRA-1-60 and Nanog. Pluripotency of derived clones was confirmed by spontaneous differentiation into three germ layers, teratoma formation and guided differentiation into beating cardiomyocytes. Conclusions: MV vectors can induce efficient nuclear reprogramming. Given the excellent safety record of MV vaccines and the translational capabilities recently developed to produce MV-based vectors now used for cancer clinical trials, our MV vector system provides a RNA-based, non-integrating gene transfer platform for nuclear reprogramming that is amenable for immediate clinical translation. http://stemcellres.com/content/6/1/48 Christopher Driscoll Jason Tonne Moustafa El Khatib Roberto Cattaneo Yasuhiro Ikeda Patricia Devaux Stem Cell Research & Therapy 2015, null:48 2015-03-26T00:00:00Z doi:10.1186/s13287-015-0035-z /content/figures/s13287-015-0035-z-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 48 2015-03-26T00:00:00Z PDF Systematic review and meta-analysis of efficacy of mesenchymal stem cells on locomotor recovery in animal models of traumatic brain injury IntroductionThe therapeutic potential of mesenchymal stem cells (MSCs) for traumatic brain injury (TBI) is attractive. Conducting systematic review and meta-analyses based on data from animal studies can be used to inform clinical trial design. To conduct a systematic review and meta-analysis to (i) systematically review the literatures describing the effect of MSCs therapy in animal models of TBI, (ii) determine the estimated effect size of functional locomotor recovery after experimental TBI, and(iii) to provide empirical evidence of biological factors associated with greater efficacy. Methods: We conducted a systematic search of PubMed, EMBASE, and Web of Science and hand searched related references. Studies were selected if they reported the efficacy of MSCs in animal models of TBI. Two investigators independently assessed the identified studies. We extracted the details of individual study characteristics from each publication, assessed study quality, evaluated the effect sizes of MSCs treatment, and performed stratified meta-analysis and meta-regression, to assess the influence of study design on the estimated effect size. The presence of small effect sizes was investigated using funnel plots and Egger's tests. Results: Twenty-eight eligible controlled studies were identified. The study quality was modest. Between-study heterogeneity was large. Meta-analysis showed that MSCs exert statistically significant positive effects on sensorimotor and neurological motor function. For sensorimotor function, maximum effect size in studies with a quality score of 5 was found in the weight-drop impact injury TBI model established in male SD rats, to which syngeneic umbilical cord-derived MSCs intracerebrally at cell dose of (1–5) x106 was administered r 6 hours following TBI, using ketamine as anesthetic agent. For neurological motor function, effect size was maximum for studies with a quality score of 5, in which the weight-drop impact injury TBI models of the female Wistar rats were adopted, with administration syngeneic bone marrow-derived MSCs intravenously at cell dose of 5 x106 at 2 months after TBI, using sevofluorane as anesthetic agent. Conclusions: We conclude that MSCs therapy may improve locomotor recovery after TBI. However, additional well-designed and well-reported animal studies are needed to guide further clinical studies. http://stemcellres.com/content/6/1/47 Weijun Peng Jing Sun Chenxia Sheng Zhe Wang Yang Wang Chunhu Zhang Rong Fan Stem Cell Research & Therapy 2015, null:47 2015-03-26T00:00:00Z doi:10.1186/s13287-015-0034-0 /content/figures/s13287-015-0034-0-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 47 2015-03-26T00:00:00Z PDF Sdf-1 (CXCL12) induces CD9 expression in stem cells engaged in muscle regeneration IntroductionUnderstanding the mechanism of stem cell mobilization into injured skeletal muscles is a prerequisite step for the development of muscle disease therapies. Many of the currently studied stem cell types present myogenic potential; however, when introduced either into the blood stream or directly into the tissue, they are not able to efficiently engraft injured muscle. For this reason their use in therapy is still limited. Previously, we have shown that stromal-derived factor-1 (Sdf-1) caused the mobilization of endogenous (not transplanted) stem cells into injured skeletal muscle improving regeneration. Here, we demonstrate that the beneficial effect of Sdf-1 relies on the upregulation of the tetraspanin CD9 expression in stem cells. Methods: The expression pattern of adhesion proteins, including CD9, was analysed after Sdf-1 treatment during regeneration of rat skeletal muscles and mouse Pax7-/- skeletal muscles, that are characterized by the decreased number of satellite cells. Next, we examined the changes in CD9 level in satellite cells-derived myoblasts, bone marrow-derived mesenchymal stem cells, and embryonic stem cells after Sdf-1 treatment or silencing expression of CXCR4 and CXCR7. Finally, we examined the potential of stem cells to fuse with myoblasts after Sdf-1 treatment. Results: In vivo analyses of Pax7-/- mice strongly suggest that Sdf-1-mediates increase in CD9 levels also in mobilized stem cells. In the absence of CXCR4 receptor the effect of Sdf-1 on CD9 expression is blocked. Next, in vitro studies show that Sdf-1 increases the level of CD9 not only in satellite cell-derived myoblasts but also in bone marrow derived mesenchymal stem cells, as well as embryonic stem cells. Importantly, the Sdf-1 treated cells migrate and fuse with myoblasts more effectively. Conclusions: We suggest that Sdf-1 binding CXCR4 receptor improves skeletal muscle regeneration by upregulating expression of CD9 and thus, impacting at stem cells mobilization to the injured muscles. http://stemcellres.com/content/6/1/46 Edyta Brzoska Kamil Kowalski Agnieszka Markowska-Zagrajek Magdalena Kowalewska Rafa¿ Archacki Izabela Plaskota W¿adys¿awa Stremi¿ska Katarzyna Ja¿czyk-Ilach Maria Ciemerych Stem Cell Research & Therapy 2015, null:46 2015-03-24T00:00:00Z doi:10.1186/s13287-015-0041-1 /content/figures/s13287-015-0041-1-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 46 2015-03-24T00:00:00Z PDF Bone marrow mesenchymal stem cells suppress metastatic tumor development in mouse by modulating immune system IntroductionBone marrow mesenchymal stem cells (BMSCs) have been studied extensively because of their potential use in clinical therapy, regenerative medicine, and tissue engineering. However, their application in tumor therapy remains yet in preclinical stage because of the distinct results from different researches and vagueness of their functional mechanism. In this study, the influence of BMSCs on tumor growth was observed and the potential mechanism was investigated.MethodTwo animal models, H22 ascitogenous hepatoma in BALb/c mouse and B16-F10 pulmonary metastatic melanoma in C57 mouse, were adopted in experience in vivo and treated with BMSCs by intravenous injection. The percentage of Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs) and IFN-γ+ T cells were observed in peripheral blood (PB) and bone marrow (BM) by Flow Cytometry. BMSCs were co-cultured in vitro with tumor cells and MDSCs in a tumor conditioned medium separately in order to illustrate the mechanism. Results: Our results demonstrated that BMSCs treatment caused a delayed tumor growth and a prolonged survival in both tumor models, the homing fraction of BMSCs in BM was 2% - 5% in 24–72 hours after transfusion and the percentage of Gr-1+CD11b+ MDSCs was downregulated in peripheral blood and BM. Meanwhile, IFN-γ+ T lymphocytes in PB increased. In vitro co-culture showed that BMSCs inhibited the induction and proliferation of MDSCs in tumor conditioned medium, whereas they didn't affect the proliferation of B16-F10 and H22 cells by in vitro co-culture. Both in vivo and in vitro results showed that BMSCs have a systemic suppressive effect on MDSCs. Conclusion: Our data suggest that BMSCs has suppressive effect on tumor and is feasible to be applied in cancer treatment. BMSCs inhibiting MDSCs induction and proliferation is likely one of the mechanism. http://stemcellres.com/content/6/1/45 Lei Zhang Xiao Su Jun Ye Yi Wang Zheng Guan Yan Yin Stem Cell Research & Therapy 2015, null:45 2015-03-24T00:00:00Z doi:10.1186/s13287-015-0039-8 /content/figures/s13287-015-0039-8-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 45 2015-03-24T00:00:00Z PDF Interaction between mesenchymal stem cells and endothelial cells restores endothelial permeability via paracrine hepatocyte growth factor in vitro IntroductionMesenchymal stem cells (MSCs) have potent stabilising effects on vascular endothelium injury, inhibiting endothelial permeability in lung injury via paracrine hepatocyte growth factor (HGF). Recently, it has been indicated that MSCs secrete more factors by MSC-endothelial cell (MSC-EC) interactions. We hypothesised that MSC-EC interactions restore endothelial permeability induced by lipopolysaccharide (LPS) via paracrine HGF. Methods: We investigated the endothelial permeability induced by LPS under two co-culture conditions. Human pulmonary microvascular endothelial cells (HPMECs) were added into the upper chambers of cell-culture inserts, while two different co-culture conditions were used in the lower side of the transwells, as follows: 1) MSC-EC interaction group: MSCs and HPMECs contact co-culture; 2) MSC group: MSCs only. The endothelial paracellular and transcellular permeability in the upper side of transwells were detected. Then, the concentration of HGF was measured in the culture medium using an Enzyme Linked Immunosorbent Assay (ELISA) kit, followed by neutralisation of HGF with anti-HGF antibody in the co-culture medium. In addition, Adherens junction and cytoskeleton proteins expression were measured by Western blot and immunofluorescence. HPMECs proliferation was analyzed by Bromodeoxyuridine incorporation assay. Results: The paracellular permeability significantly increased after LPS stimulation in a dose-dependent and time-dependent manner. Meanwhile, MSC-EC interaction more significantly decreased endothelial paracellular and transcellular permeability induced by LPS. Moreover, HGF levels in the MSC-EC interaction group were much higher than those of the MSC group. However, neutralising HGF with anti-HGF antibody inhibited the role of MSC-EC interaction in improving endothelial permeability. Compared to the MSC group, MSC-EC interaction increased VE-cadherin and occludin protein expression, reduced caveolin-1 protein expression in HPMECs and restored remodelling of F-actin and junctional localisation of vascular endothelial cadherin (VE)-cadherin. Furthermore proliferation ratio in MSC-EC interaction group was higher than that of MSC group. However, the effects of MSCs was significantly blocked by anti-HGF antibody. Conclusion: These data suggested that MSC-EC interaction decreased endothelial permeability induced by LPS, which was mainly attributed to HGF secreted by MSCs. The main mechanisms by which HGF restored the integrity of endothelial monolayers was remodelling of endothelial intercellular junctions, decreasing caveolin-1 protein expression and inducing proliferation in HPMECs. http://stemcellres.com/content/6/1/44 Qi-Hong Chen Ai-Ran Liu Hai-Bo Qiu Yi Yang Stem Cell Research & Therapy 2015, null:44 2015-03-24T00:00:00Z doi:10.1186/s13287-015-0025-1 /content/figures/s13287-015-0025-1-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 44 2015-03-24T00:00:00Z PDF Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis IntroductionThere is a practical need for the identification of robust cell-surface markers that can be used to enrich for living keratinocyte progenitor cells. Breast cancer resistance protein (ABCG2), a member of the ATP binding cassette (ABC) transporter family, is known to be a marker for stem/progenitor cells in many tissues and organs. Methods: We investigated the expression of ABCG2 protein in normal human epidermis to evaluate its potential as a cell surface marker for identifying and enriching for clonogenic epidermal keratinocytes outside the pilosebaceous tract. Results: Immunofluorescence and immunoblotting studies of human skin showed that ABCG2 is expressed in a subset of basal layer cells in the epidermis. Flow cytometry analysis showed approximately 2-3% of keratinocytes in non-hair-bearing epidermis expressing ABCG2; this population also expresses p63, β1 and α6 integrins and keratin 14, but not CD34, CD71, C-kit or involucrin. The ABCG2-positive keratinocytes showed significantly higher colony forming efficiency when co-cultured with mouse 3T3 feeder cells, and more extensive long-term proliferation capacity in vitro, than did ABCG2-negative keratinocytes. Upon clonal analysis, most of the freshly isolated ABCG2-positive keratinocytes formed holoclones and were capable of generating a stratified differentiating epidermis in organotypic culture models. Conclusions: These data indicate that in skin, expression of the ABCG2 transporter is a characteristic of interfollicular keratinocyte progentior cells and suggest that ABCG2 may be useful for enriching keratinocyte stem cells in human interfollicular epidermis. http://stemcellres.com/content/6/1/43 Dongrui Ma Alvin Chua Ennan Yang Peiyun Teo Yixin Ting Colin Song Ellen Lane Seng Lee Stem Cell Research & Therapy 2015, null:43 2015-03-24T00:00:00Z doi:10.1186/s13287-015-0032-2 /content/figures/s13287-015-0032-2-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 43 2015-03-24T00:00:00Z PDF Adipose derived stem cell-based treatment for acute liver failure IntroductionAcute liver failure (ALF) is a highly lethal disease, for which effective therapeutic methods are limited. Although allogeneic liver transplantation is a viable treatment method for ALF, there is a serious shortage of liver donors. Recent studies suggest that stem cell transplantation is a more promising alternative approach. Hence, we investigate whether human adipose derived stem cell (ASC) has the therapeutic potential for ALF in this study based upon the studies of rat models. Methods: Sprague Dawley (SD) rats were used to establish ALF models by D-galactosamine (D-gal) injection. These rats were randomly divided into the human ASC treated group and the phosphate buffered saline (PBS) control group. The human ASCs or PBS were transplanted through the spleen of rats. The indices of hepatic function and hepatic histology were dynamically detected, and the survival rates of rats were also counted. Double fluorescence immunohistochemistry was employed to detect the ASC fate after transplantation. Moreover, both concentrated ASC conditional media and ASC lysates were transplanted through femoral vain of rats to investigate the therapeutic potential for ALF. Results: The ASC transplantation group showed improved viability than sham control. Histological and biochemical analysis suggested that liver morphology and function were improved in terms of cell proliferation and apoptosis. Although a plethora of ASCs persist in the spleen, the improvement in liver function was obvious. However, ASCs did not differentiate into hepatocytes after engrafting to livers within three days. In addition, both concentrated serum-free ASC conditional media and ASC lysates, characterized by high levels of HGF and VEGF, demonstrated obvious improvement in terms of high survival rates of ALF rats. Conclusions: Our data suggest that ASC transplantation has the potential for acute liver failure treatment partly by the mechanism of secreting growth factors contributing to liver regeneration. http://stemcellres.com/content/6/1/40 Guangfeng Chen Yinpeng Jin Xiujuan Shi Yu Qiu Yushan Zhang Mingliang Cheng Xiaojin Wang Chengwei Chen Yinxia Wu Fuzhu Jiang Li Li Heng Zhou Qingchun Fu Xiaoqing Liu Stem Cell Research & Therapy 2015, null:40 2015-03-21T00:00:00Z doi:10.1186/s13287-015-0040-2 /content/figures/s13287-015-0040-2-toc.gif Stem Cell Research & Therapy 1757-6512 ${item.volume} 40 2015-03-21T00:00:00Z PDF