text:
Floor Plans and Pricing
1 Bedroom
|Plan A
|$1380 - $1430
|1 Bathroom
|600 Sq. Ft.
|Plan B
|$1400 - $1465
|1 Bathroom
|655 Sq. Ft.
|Plan A1
|$1575 - $1610
|1 Bathroom
|600 Sq. Ft.
|Plan B1
|$1600 - $1635
|1 Bathroom
|655 Sq. Ft.
2 Bedrooms
|Plan C
|$1645 - $1715
|2 Bathrooms
|925 Sq. Ft.
|Plan D
|$1745 - $1780
|2 Bathrooms
|962 Sq. Ft.
|Plan C1
|$2050 - $2080
|2 Bathrooms
|925 Sq. Ft.
|Plan D1
|$2150 - $2180
|2 Bathrooms
|962 Sq. Ft.
Property Features
- Property Overview
- Special Features
- Community Features
- Apartment Amenities
- Local Schools
- Pet Policy
Club Torrey Pines in San Diego, CA
Club Torrey Pines offers one and two bedroom apartments for rent in Carmel Valley. Club Torrey Pines is a well-maintained property with outstanding common area amenities.Resort-style amenities are the focus of this garden-style two-story walk-up one and two bedroom luxury apartment community centered in Carmel Valley. Proof of Renter's Insurance required upon move in.
Special Features
- Stainless Steel Appliances
- Granite Counter Tops
- Double Pane Windows
- Washer/Dryer in Units
- Spacious Closets
- Free Movie Rental
- Nearby Shopping
- Fully Equipped Kitchen
- Recess Lighting
- Minutes from the Beach
- Dark Wood Like Plank Flooring
- Two Barbecues
Community Features
- Accepts Electronic Payments
- Apartment
- Business Center Onsite
- Club House
- Covered Lot
- Fitness Center
- Freeway Access
- Garden Style
- Garden Style
- Pool
- Spa
- Surface Lot
- Tennis Court
Additional Information
Year Built: 1988
Apartments in Community: 400
Apartment Amenities
- Carpet
- Ceiling Fan
- Dishwasher
- Garbage Disposal
- Gas Utilities Included
- Internet Access
- Microwave
- Patio or Balcony
- Tile Floors
- Walk In Closets
- Washer Dryer In Unit
- Window Covering
Local Schools
- Carmel Creek Elementary School
- Carmel Valley Middle School
- Solana Pacific School
- Torrey Pines High School
We believe school data to be accurate, but do not guarantee that. Please be sure to verify where your children will attend school before making your housing decision.
Pet Policy
Sorry, no pets.
Web Reviews
User Review
Contact Club Torrey Pines
Club Torrey Pines
Office Hours7 Days A Week Mon-Sat: 8:30 to 5:30 Sun: 10-5 PM
1 Bedroom and 2 Bedroom Apartments with Washer and Dryers, Gym, Lap Pool, Spa, Tennis Courts, and much more.
From I-5 exit Del Mar Heights East to Torrey Ridge, turn right. Go to Torrey Bluff Drive, turn right. Look for front entrance by Club Torrey Pines monument, turn right into parking lot.
As you search for your perfect apartment, please keep in mind that rental rates (including specials and discounts) and availability are very fluid in the apartment industry. Based on many factors, the rental rates (including specials and discounts) and availability can actually change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rental rates or availability you may find here now at ForRent.com may not be the same as when you contact the communities.
Quick Links For Your Apartment Search
- San Diego metro
- North Coastal San Diego area
- San Diego
- 92130
- See Also


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I am an INFJ.
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- Education
- Graduated from masters program
- Job
- Medicine
- Income
- $60,000–$70,000
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subset: commoncrawl


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Favorite custom or semi-custom white painted wood cabinets
This is such a great forum for newbies to reno!
We are in the process of a major renovation that includes our "dream kitchen". I'm looking for durable, quality custom or semi-custom painted white wood cabinets (SCD, hidden hinges, dovetail, plywood box) that is within our budget (WoodMode is not). Looking at frameless or inset construction.
What is your favorite cabinet manufacturer for the above and why? We live in Pennsylvania.
Thanks in advance!
We have Fieldstone cabinets (right down here in MD) and we're very happy with them, but ANY added features sneak up the price. (All of the "add ons" for convenience - trash pullout, racks, tilt outs, etc. are Rev-a-Shelf so if you or your contractor are handy, save the $ and order then cabinet and then add those on yourself.)
And, it's really not the cabinets that get you, it's the arches or the mantel over the stovetop etc.
That said, I think the quality is outstanding and we're very pleased with the finished results.
(There are about 6 to 8 shades of "white" available. Our kitchen is Macademia, which is actually a creamier color. We did a bath in Marshmallow which is a very pretty soft white.)
Good luck!
Here is a link that might be useful: Fieldstone Cabinetry
If you are near an Amish cabinetry maker, you may find they can do the kitchen for the same cost
I have Crystal Cabinet Works beaded inset cabinets and I'm very pleased. I purchased mine during a "free paint" and "free inset" promotion. They allow you to combine their Keyline (less customization, lower price) and full custom offerings that keeps their pricing in the mid to mid-high category. (They were far less than the Fieldstone). They have a good reputation here and among my preferred contractors.
There is a good thread here on pricing comparison of white painted shaker cabinets.
Not sure where in PA you are, but Dutchwood Kitchens in Myerstown did our whole house and a bunch of the kitchens for people on here. They are affordable and really high quality.
This post was edited by beaglesdoitbetter on Fri, Sep 13, 13 at 23:46
I am getting ready to place my order for Shiloh cabinets, white beaded inset. They seem very nice from the ones I saw in the showroom and I have seen a lot of others on here comment that they are happy with theirs. They offer the inset at no additional cost above the overlay. They have several whites, glazes, highlights, etc.
Akcorcoran- your kitchen is beautiful (just love it)! How many years have you had the cabinets? Thanks so much for sharing a pic of your kitchen. The granite color is also along the lines of what we are looking for. We are in SE PA so MD is not far away at all. I definitely will check it out. Love that there are many different shades of white which is hard to find.
I will look into Dutchwood (not one I'm familiar with but love that it local). Shiloh is on my list as well- very few manufacturers offer no cost inset.
Thanks to all these great options to consider!
Thanks! We've had them approximately 1/3 of a year - installed in April! :-) I'm a fan of timeless kitchens but our house is a 1917 Colonial so it needs to look new but old. The granite is Typhoon Bordeaux (ours is Typhoon Bordeaux Green but there is also Silver and other variations.)
Lots of great options here - good luck!
doughert if you check around GW, there's a whole bunch of dutchwood kitchens. Beekeeperswife, Tom in Nj has one. Finestra. Michelle16. Probably more.
Here's some threads:
You live in Pennsylvania? I live 10 hours from you (PA) & I was so hoping Dutchwood would make my cabinets. That was right about the time they were getting so many orders, they had to restrict their orders to within a certain geographical area. So many beautiful kitchens made by Dutchwood: Michelle16, Beekeeperswife, Finestra, Beaglesdoitbetter. So custom, whatever you want, Jason & his crew make it happen. They didn't make my kitchen cabinets & I know their names!
Thank you for this thread since I am trying to decide to go with full overlay kitchen cabinets, beaded inset cabinets or flush inset cabinets. Gooster, I must look at your pictures again close-up as I did not realize they were beaded but they sure are beautiful!


text:
BATON ROUGE – The LSU men's basketball team, coming off a 20-win NIT season, will play for the second straight year in the 24-hour ESPN College Hoops Tip-Off Marathon on Nov. 18.
Click here for the original story.
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Posted July 1, 2013 by Dean Amond in FYIG Features
Magazine Monday #41 – Nintendo Power Issue #39 – August 1992
Here's the next edition of Magazine Monday, this time from 1992. In this issue of Nintendo Power, you'll see features on Mario Paint, CES 1992, a lengthy Zelda comic and so much more!
*All thanks goes to RetroMags. No copyright infringement intended, Magazine Monday is simply to appreciate the print magazines of days gone by that can no longer be purchased*
casino kid 2 contra force game boy gaming magazines gargoyle's quest II kirby's dream land mario paint nes Nintendo nintendo power snes teenage mutant ninja turtles iv turtles in time
Dean Amond
I started FindYourInnerGeek.ca in May of 2012 because I wanted to do things a little differently and cater to some of my favourite interests.
More articles by Dean Amond »
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- game boy
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text:
Posted by ESPN.com's James Walker
Cleveland Browns general manager George Kokinis released a statement Tuesday night following the latest developments surrounding the future of veteran receiver Donte' Stallworth, who received a 30-day jail sentence after pleading guilty to DUI manslaughter.
- "The Browns are very conscious of the seriousness of the charges to which Donte' Stallworth plead guilty to today," Kokinis said. "We are continuing to evaluate the situation and will make the decisions that we believe are in the best interest of the Cleveland Browns."
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Joe Donahue speaks with Newt Gingrich5/16/07
Albany, NY – Former Speaker of the House, and the man behind the Contract for America, Newt Gingrich discusses his plans for running for president, as well as his latest Novel, Pearl Harbor: A Novel of December 8th.
Pearl Harbor: A Novel of December 8th, by Newt Gingrich and William R. Forstchen. Published by Thomas Dunne Books.


text:
You may also like
Dr. Glenn Chan
Rate Dr. Rod Herchak
Dr. Rod Herchak's Ratings
Do not go to this dentist. I went in to get a standard filling about 2 and a half weeks ago and it was one of the worst dentist appointments of my life. I felt everything...everything was very rough. He barely said a word to me the whole time and kept on rubbing his instrument on the corner of my lip. I also thought he was very aggressive. I was soooo sore the next day from where he massaged my gums (again aggressively hard) to get the freezing to spread. I was also left with a cut on the side of my lip from him resting and rubbing the instrument so hard.
Anyways....flash forward 2 and a half weeks later and the ache where I got the filling is unbelievable. I went back last week and saw a different dentist to get it checked out and had to go again yesterday as the pain has gotten worse.
Now, I'm freaking scheduled for a root canal all because this dentist did a botched filling. This makes me so mad. Please, do not go to this dentist.
Was this rating useful? 1 [[ userState['ratings'][2743643].votes_count ]]
Beware of new dentists taking over. Dr. Herchak was awesome and I wish he found a suitable replacement. I went in for xrays, cleaning and complained of a pain high up in my gums. They said they found nothing wrong just a couple cavities. The next appointment I asked if the cavity was over where I showed him the sensitivity was. Nope so again I had to pay for more xrays even though I already paid for a full scan last time. Turns out I need a root canal and he said it's really bad. Why couldn't he see this on the first scan they did of all my teeth especially when I had already pointed out the area of discomfort. Then the hygenist and dentist flirted intensely as I got my cavities fixed to the point where I was uncomfortable. The water sprayer was broken so it regularily sprayed me in the face. As well their headset and tv was broken so I had to listen to them flirt. They also have no clue when it comes to prescriptions.
Was this rating useful? 0 [[ userState['ratings'][2738505].votes_count ]]
Be very careful.... the office is totally disorganized and inexperienced. Staff is rude and does not care about the patients; money only. It is not how it used to be. Young people have lots to learn from an older generation.
Was this rating useful? 0 [[ userState['ratings'][2729267].votes_count ]]
This office has gone downhill - now full of a bunch of clueless amateurs. Watch out!!! I have been a patient of Rods for 25 years, the level of care I recieved over the years from Rod and his entire staff was bar none. I called the office in extreme pain, was told Dr. Herchak would not see me - even though they never asked him personally. Out of desperation I came in to see another Dentist as the office Manager said that was my only choice. Walked in to the office, 3 girls sitting behind desk giggled and gossiped as I stood there looking right at them - completely ignored me! I was floored! Then I end up waiting 40 min for my appt - something Rod never did. Again having to listen to the Three amigos learn what a root canal is, don't you work at a dental office? Even I know what. Root canal is! Scary. The young Dr was fine enough but his inexperience and lack of bedside manner very apparent. Water soaked me through out appointment - rougher than I'm used too. Things got really bad as I went to leave the office. First Lady (Reagan) tells me I owe $600 for the crown I just got...I didn't get a crown! Then she starts to argue with me telling me I have to pay my insurance didn't cover! That is office policy. This went on for 10 minutes, she gets her office Manager Meena who was even more ignorant!!! They are giving me documents to sign with someone else's name all over it! It is very clear none of these people have worked at a dental office before. Turns out I owed nothing for my filling since insurance paid IT all! Then she tells me I am due for teeth cleaning, that's fine. I try to book but she tell me I can't see my regular girl she is booked, I have to see the a differant hygenist. Funny because I had said hi to her while I waited and she told me personally I could see her next week. This place is fishy!!! That was the last straw! I am so done with this office. Rod is great, my Hygenist is great but enough is enough. This office has been going downhill fast over the last year. Now I come on here and see the office has been sold. The waiting room and reception area is a pigsty full of uninformed, ignorant, rude staff. If you could get past them and actually get an appointment with Rod you would be happy - but not worth my time.
Was this rating useful? 1 [[ userState['ratings'][2712795].votes_count ]]
Dr. Herchak is a great dentist! He is very punctual and concerned about the care he gives his patients. I would recommend him! Unfortunately there appears to be less focus of patient care given by the girls sitting at the front desk! I called to confirm my hygiene appointment (like I always have) and I was told I didn't have an appointment?? I had it scheduled in my daytimer so yes, after further discussion and determination I had an appointment. I wish Dr. Herchak didn't sell his practice. It was well-managed and the staff he had were amazing! Just to add: why did the last review mention Dr. Lowry when I was looking up Dr. Herchak?
Was this rating useful? 2 [[ userState['ratings'][2654281].votes_count ]]
One of the best clinics and Dentists I have ever seen. Dr. Herchak has been seeing my mother for years and recently I took her to his clinic. I found him to be kind and caring towards my elderly mother. He has excellent bedside manner, was kind, gentle, fantastic staff (the girl at the front was so nice and cheerful) and great overall. I ended up booking my kids to see Dr. Lowry (for braces)who works with Dr. Herchak in the clinic and found him to be just as fantastic!! So happy to find a Dentist who actually cares about you.
Was this rating useful? 1 [[ userState['ratings'][2631864].votes_count ]]
Dr. Herchak is the best dentist I've ever come across. He has an excellent bedside manner, is very personable and actually cares about you & your dental health. The staff at his office are incredible, they are so helpful, efficient and very friendly. He recently sold the practice but still works there and I had a filling from one of the new dentists there, he also was very good. If you're looking for a great dental office, do yourself a favor and book an appt!
Was this rating useful? 2 [[ userState['ratings'][2591320].votes_count ]]
Dr. Herchak and his staff are impeccable! Always very thorough, personable and his hygienists have a lot of knowledge about proper oral hygiene. I went to another dentist before him that told me I had cavities and Dr. Herchak came to the conclusion I had no cavities after x-rays so that was definitely an eye opener. The previous dentist was also quite angry when I left to move over to Dr. Herchak because I assume he knew I had no cavities & was trying to get money out of me. So glad that I found Dr. Herchak.
Was this rating useful? 1 [[ userState['ratings'][1401437].votes_count ]]
I went into Dr.Herchak's office as a new patience for a yearly cleaning and check-up. I also had a couple teeth I thought might have cavities. Dr. Herchak looked in my mouth for about five seconds and said all looked good. That seemed very weird to me. I asked my hygienist about this and she was super helpful and suggested strongly I see either Dr. Boruah of Dr.Piccoli. Thank goodness she did I went to Dr. Boruah and I had four cavities. He has tackled one of my cavities so far and he has been very gentle and understand. Thank you to the staff and my amazing hygienist for telling me to see dr.b (as he likes you to call him). I recommend Dr. Boruah for sure.
Was this rating useful? 1 [[ userState['ratings'][1401436].votes_count ]]
Dr Herchak and his staff are amazing! I have issues with dentists usually and suffer from severe panic attacks before appointments. Everyone was calm, helpful, and positive. I was surprised at how much I was looking forward to going back, and how consistant the environment is. I won't be going to any other dentists office because of the high quality work, the friendly environment, the compassionate staff, and the convienent location offered by Dr Herchak's office.
Was this rating useful? 0 [[ userState['ratings'][1401435].votes_count ]]
Top Hospitals in Calgary, AB
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text:
Visit create.airbnb.com »
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Couple charmant, ponctuel.
Pierre and his family have been a great guests, very neat and excellent people. I recommend them!
Tout s'est très bien passe. Couple très agréable.
Lovely guest! Thank you Pierre!
Pierre, is wife, daughter and parents stayed for two nights while they explored Sonoma County. His parents were visiting from France. They were a delight! Their little 2 1/2 year old girl was vibrant and liked strumming my ukulele and loved my cat. They were all respectful of the space, cleaned up after themselves and I enjoyed they visit. They are an interesting young couple and great guests.
I hosted Pierre and his family for three nights in April. I have hosted about 150 groups of guests in airbnb so far. I have to say that Pierr is in the bottum 5%. The bigest problem is that he is not responsive at all. Before his arrival, I contacted him several times regarding some important and urgent matters. He did not respond for almost one month. He only responded when I threatened to cancel his reservation. This really gives me a lot trouble. The only up side is that he finally did what he has agreed to do. But this is really not worth the hazzel.
Charmant jeune couple , petite fille adorable à croquer
Un plaisir de les recevoir
Bon vent en Californie
Mathew and I were away on a long weekend so our friend Eliza let Pierre and his family into our home. Eliza loved them! She says they are the cutest and nicest family. Pierre even sent me a photo of their daughter riding on our rocking horse. The house was left in perfect condition. Dream guests! I hope to go stay in their home in Paris!!
Pierre and his family were excellent guests. Even though he was coming from France, we communicated well. I hope he will stay at my home again!


text:
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BMW is a long standing producer of rock solid and dependable vehicles that also feature innovative design. It's no shock that safety and comfort-conscious vehicle owners know how to find the highest quality at a fair price when buying BMW X5 car parts. If a problem crops up or a system must be replaced, that's not the time to save with a second-rate component. Your BMW X5 deserves the right car parts to function at top efficiency. If you get a BMW, you have the pride in a well-built vehicle, and that's intrinsically rewarding. Comfort-focused sedans such as the well-appointed BMW X5 were built to be used with care and attention and also maintained well. Wrap yourself in beauty, high-quality and innovative appeal with the help of a classic BMW auto.Your car or truck is an investment due to its excellent performance and great style, so to keep it humming in top form you need the ultimate in quality parts and accessories. Your vehicle's BMW X5 Fan Shroud is commonly made out of high-stress materials. If your BMW X5 Fan Shroud is damaged, it may possibly have trouble dissipating heat. The BMW X5 Fan Shroud holds the car's radiator fan solidly in alignment with the engine. A new BMW X5 Fan Shrouds supports proper air flow and increase correct cooling of the motor. Your BMW was put together using the best quality and expertise; it ought to have new parts with the same high level of value.
They are available for the following BMW X5 years: 2006, 2005, 2004, 2003, 2002, 2001, 2000, 06, 05, 04, 03, 02, 01, 00. This part is also sometimes called BMW X5 Radiator Fan Shrouds. We stock fan shroud parts for most BMW models including 528i, 325i, 525i, 740iL, 530i, 328i, 540i, Z3, 323i, 325Ci, 325is, 325xi, 740i, 330i, 330Ci, M3, 328is, 535i, 323Ci, 318i, 750iL, 330xi, 528e, 735i, 323is, 325, 840Ci, 735iL, 325es, 328Ci, 533i, 325e, 325iX, 318ti, M5, 318is, 635CSi, 535is, 320i and 633CSi.
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Good service.Ships quickly.
very happy with your service. parts were ok and fast delivery. I wiil shop again soon. thank you Raul


text:
1997 Ford Taurus • 109,000 miles
Engine start, run rough, then stall
December 7, 2012.
December 7, 2012.
Need more info. Engine size. Sounds like it may have a vacumn leak, Standing on the pass side of the engine, look down on the upper pleneum, there is a l shaped vac. Nipple that is bad about rotting away and leaking. If it is bad you can check it by temporarily pluging the port off. If it runs now and idles you have your problem, go to the parts house and tell them, or show them what is left of yours, they should have it for around 3 bucks. Thanks for using 2CarPros
Dec 7, 2012.
Dec 7, 2012.
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9:00pm IST RIO DE JANEIRO (Reuters) - Beach volleyball will hold midnight matches on Copacabana beach during the 2016 Olympics in Rio de... ...http://in.reuters.com/article/2015/03/20/us-olympics-beachvolley-idINKBN0MG1WP20150320?feedType=RSS&feedName=lifestyleMolt
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text: by Kristina Gill FACEBOOK TWITTER PINTEREST Kayla Huff April 21st, 2012 That looks very yummy. I really like the dish. LEAVE A COMMENT Design*Sponge reserves the right to restrict comments that do not contribute constructively to the conversation at hand, contain profanity, personal attacks or seek to promote a personal or unrelated business.


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|February 11, 2015, 02:31 AM
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Join Date: November 25, 2012
Location: Oregon
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how well does pictanny rail hold zero?
Ive never considered this before but with the ease of clamping sights on a pictanny rail the thought hit me one could possibly swap out different optics or sights providing the sights returned to zero.
lets say you have a pictanny rail mounted scope, zeroed at 300 yards. If you remove the scope and re-install it in the same position how well does it hold its sight in?
lightweight, cheap, strong... pick 2
|February 11, 2015, 02:38 AM
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It aint because you can not line it up in the precise position as it was before.
|February 11, 2015, 03:35 AM
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I have swapped scopes quite a few times on picatinny rails, and return to zero is mostly a matter of mount quality and technique. I have never had a perfect return to zero, though. (Within 1-2 MoA, but that's about as good as it gets with my equipment.)
If you're using a crappy mount that doesn't index solidly on the rail, return to zero will not be great.
If you don't use consistent technique, return to zero will not be great.
I have even had a scope go back and forth between a trio of ARs, and the zero was within 2-3 inches @ 100 yards, across the lot of them.
As far as technique goes...
All of the optics that I have swapped back and forth* have had the fixed side of their mount on the left side, and the clamping jaw on the right side.
So, by setting the mount on the rail and pushing down, forward, and right, while snugging down the clamping hardware, return to zero has been excellent.
That pushes the mount down against the rail, to the front of the slots in the rail (where recoil will try to force them, later), and against one side of the rail.
Finishing by tightening the screws/nuts to the same torque also helps.
*I have also swapped a scope wearing Millet windage-adjustable rings, but I went into that situation knowing full well that there was no hope for a return to zero. Without fixing the clamps on one side of the rings, there is no way to lock them in place for repeatability.
"Such is the strange way that man works -- first he virtually destroys a species and then does everything in his power to restore it."
|February 11, 2015, 04:25 AM
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Join Date: February 6, 2014
Posts: 409
It all depends on the quality of the mounts. Get high end mounts from a good manufacturer and they should be close. A camming lever will be best.as it should give you the same torque on ths mount. Thumb screws will pull to one side unless the torque is perfect.
|February 11, 2015, 10:18 AM
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Location: Georgia
Posts: 6,430
I've done so with both rails and Weaver type rings and bases. The key is proper technique. When you initially mount the scope slide the rings as far forward as possible then tighten the rings. During recoil they want to move forward anyway, if they are already as far as they can go you'll get no movement. If you remove it, slide it as far forward as possible when re-mounting.
I've never had to do anymore than minor tweaking of the scope adjustments after. Certainly not off enough to cause a miss on deer size game at reasonable ranges.
|February 11, 2015, 02:20 PM
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I swap scopes back and forth on my R15. As stated technique is a big part of it. Push it forward before you tighten it down. When I started it took a few times on and off before it started holding zero pretty well. Not well enough I would have wanted to shoot a match or anything, but certain not off enough to cause me any lost sleep for coyotes, deer, or pop cans.
|February 11, 2015, 03:11 PM
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Posts: 6,196
I've removed, replaced, swapped scopes on rail for decades. They all return to set zeros with my Weaver or Tasco rings with 1/4 MOA error, at most. All with thumb or coin screws torqued to some amount. There's a bigger difference in atmospheric conditons to think about.
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|February 11, 2015, 03:29 PM
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Location: Douglasville, Ga
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yes, if your mounts are fitted nicely and lock in at the same position, shouldn't be an issue. I would assume a nice one-piece mount would be ideal for changing scopes around a lot.
My head is bloody, but unbowed
|February 11, 2015, 10:35 PM
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Join Date: December 10, 2012
Posts: 2,889
Depends on who makes the rail and who makes the rings. It also depends on how you install them.
|February 11, 2015, 10:53 PM
Join Date: April 4, 2012
Posts: 58
I've went exclusively to Bobro mounts on my AR's. They're the best at returning to zero that I've experienced. Usually spot on.
|February 12, 2015, 02:25 AM
Senior Member
Join Date: October 9, 2009
Location: North Alabama
Posts: 4,660
works for me
I've got a set of Leupold QR Levers (rings) on a Savage Scout, and the scope has been on and off numerous times. The Savage scout rail appears aluminum. The rifle comes back to within 1MOA or less, every time, so much so that I don't worry about it.
I changed slots, and THAT did effect POI enough that I had to rezero.
|February 12, 2015, 05:42 PM
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Location: Albuquerque
Posts: 2,440
I use Warne QR rings for my takedown Browning BRL, I got within 1 MOA repeatability on a 4 series test (initial and three remount). As the gun groups 2 MOA it was basically only a slight shift within an overall 3" grouping.
I used to love being able to hit hard at 1000 yards. As I get older I find hitting a mini ram at 200 yards with the 22 oddly more satisfying.
|February 13, 2015, 06:59 AM
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Join Date: December 19, 2008
Location: Central SC
Posts: 322
I have a couple of Warne's, close, but not exactly. I have a couple of Badgers, they are about dead on every time if I take the scope off and put it back.
|February 13, 2015, 11:45 PM
Senior Member
Join Date: November 13, 2006
Posts: 4,021
To begin,in my head from draft angle days,a degree is about .017+ thousandth of an inch,per inch.
Just to illustrate the math,doing it in our head,lets call it .016 thou per in.
Now,just for this example,lets make the ring spacing 4 inches.
What would a .001 lateral or vertical error do to POI?
Well,.016 per in would be .064 over 4 in for 1 deg.As there are 60 MOA per deg,64 thousandths would translate roughly to 1 MOA per .001 error in ring to rail variation.
The design of the picatinny rail is quite similar to machine shop fixturing.
If the surfaces are accurately machined,clean,and have no burrs ,dings,casting roughness,etc they should repeat postioning to way less than .001 .That is a big "IF".
There is another issue.Alignment.If the scope rings are not perfectly clocked to the same orientation on the tube,tightening the rings to the base makes the scope tube a torsion bar.That introduces variability.Tightening the ring clamp screws can easily introduce this error.
Two piece bases?.Unless you have set up on a granite surface plate with a test indicator and confirmed alignments,do not assume the front and rear bases and the rings will all come into alignment.If they are not coaxial,tightening the rings to the bases involves flexing the scope tube.
This "springy" stuff makes repetition tough.
I thinkif you have a flat,true,rigid rail,such as on a quality AR upper,and you use a quality one piece ringmount,that is precisely CNC machined,
so that clean,non stressed surfaces can come together,repeatition will be very close..Should be easily sub MOA.
Last edited by HiBC; February 13, 2015 at 11:50 PM.
|February 14, 2015, 01:22 AM
Senior Member
Join Date: November 25, 2012
Location: Oregon
Posts: 569
Some good information, it sounds like if one expects to interchange optics then a well machined 1pc mount is the way to go
lightweight, cheap, strong... pick 2
|February 14, 2015, 01:29 AM
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Join Date: August 25, 2008
Location: 1B ID
Posts: 7,316
You guys with your sub-MoA talk are making me regret never measuring the actual deviation when re-mounting the scopes on my ARs. Next time I'm out, I'll have to see if I mis-remembered the "2-3" @ 100 yards" and the return to zero is better than that, or if I'm not losing my memory, after all.
"Such is the strange way that man works -- first he virtually destroys a species and then does everything in his power to restore it."
|February 14, 2015, 02:04 AM
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Posts: 161
|February 14, 2015, 06:57 AM
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Join Date: February 2, 2010
Posts: 2,659
"A camming lever will be best.as it should give you the same torque on ths mount. Thumb screws will pull to one side unless the torque is perfect."
Better check this? While a cam may create a repeatable clamping force, most also act against only one side of the mount-same as a screw. If a throw lever mount acts on BOTH sides of the rail, it most certainly WILL NOT be as repeatable as a screw clamp with one solid side.
|February 14, 2015, 08:24 AM
Senior Member
Join Date: February 15, 2009
Posts: 6,196
To make simple/easy angular error calculations easy for two things some length apart:
* 1/3600 of the length equals 1 MOA.
* 1/60th of the length equals 1 DOA (degree of angle).
That fits the USA shooting sports '1 MOA = 1 inch per hundred yards' standard.
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Last edited by Bart B.; February 14, 2015 at 08:33 AM.
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... had to head back up the hill in the dark and drive home on the freezing roads. Our little VW Golf made the ride home more comfortable due to the temperature controlled seat warmers. Warm tushies = happy Arizonans. Once home we had another hot chocolate and ate some of the cookies we had bought at a market stand offering samples. Yup, they got us and we couldn't be happier.
December 15th
We are both having a problem with jet lag this ...
Beer in an old town.
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Old town was really pretty. Nice blue stone buildings all from the local quarry. A castle and a church in the heart of town. There were two similar rock structures which we still don't know quite what they were. These were round semi circles in the rock face. Estimating about 20m high... so large.
Once we explored the town we went to the larges topiary garden open to the public IN THE WORLD. ...
On to belgium!
Left for belgium this morning. Just entered the french speaking country and I read about some caves in liege, belgium that I will try to find. And then onto brussels.. an intereting thing in europe is all the public bathrooms cost money to use... here are some pictures of the roads. The sign that looks like a ghost busters sign means theres no speed ...
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Well, another fantastic day at Castle Kerpen! We enjoyed having the castle all to ourselves yesterday and this morning. A scrumptious breakfast was laid out for us by Anna who came in to work here this morning. This was followed by relaxing, exploring, dressing up, building block ...
... evening. We ended up being stranded in a town in the middle of Nowhere, Germany and ended up staying the night in an odd little inn. We got up early the next morning to catch a 6:30am train and were back on our way. After a full 24 hours of traveling, we finally reached our hostel and were able to check in to our rooms at long last. It was a total fluke of a stop and although we never intended to, we added a pin in our map somewhere in northern Germany.


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Cancer Health Center
Uterine Sarcoma Treatment (PDQ®): Treatment - Patient Information [NCI] - About This PDQ Summary
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Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.
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This PDQ cancer information summary has current information about the treatment of uterine sarcoma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.
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#include <std_disclaimer.h> /* * Your warranty is now void. * * We are not responsible for bricked devices, dead SD cards, * thermonuclear war, or you getting fired because the alarm app failed. Please * do some research if you have any concerns about features included in this ROM * before flashing it! YOU are choosing to make these modifications, and if * you point the finger at us for messing up your device, we will laugh at you. */
- PMEM based
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text:
Hello, (hope this is in the right forum)
First Post, glad to be here!!! I'm fairly new to brewing... Like a lot of people I started out doing the Mr. Beer thing... I've brewed that stuff for a little over a year. So, I would like to say I know the basics and have done a little research. I have now moved to doing my first non-MB extracts. I still brew 2.5 gallon batches because I live in an apartment and my MB fermenters fit so nicely in my closet.
I am trying to create my first IPA on my own based off a few recipe's I've found here and elsewhere. I really would just like another to eye the recipe and see if I made any flaws or anything just looks wacky. Thanks in advance.Note: I created this brew in beersmith and it seems to agree it will turn out to be an IPA
2.5 gallon batch...Recipe - INTERN ... IPA
.5 lbs Crystal Mal 60L - Crushed ... Steep 30 mins in 1.5 gallons of water.
3 lbs Extra Light DME - 1 lb @ 30 / 2lb @ 10 mins
.5 oz Warrior Hops - Added @ 30
.5 oz Amarillo Hops - Added @ 15
1/10 tsp Irish Moss - Added @ 15
.5 lbs Honey @ flameoff.
Safale US-05
.5oz Amarillo hops Dry Hopped for 4 days.
Any advice would be great!
For a 5 gallon batch I would say your .5 lb Crystal is spot on, but since you're doing 2.5 gallon batches I'd say to back off a bit on the Crystal to .25 lb. I don't know what the AA% of your hops are, but that seems a little weak for an IPA hop bill. I'd add some more addition between 15 min and flame out as well as increase the dry hop amount to 1.5 - 2 oz or so. That way you get big hop aroma and flavor with the clean bitterness from the Warrior. The way you have it now it seems like a APA hop bill with an IPA grain bill which will lead to the perception of excessive sweetness.
The only thing more asinine than stupid rules is the enforcement of rules simply because they are the rules.Inhopsicated: A Beer BlogInhopsicated on Twitter
Thanks for the reply!
I tend to agree with you on the mixing of styles, as I am a fairly new I just kind of threw this together. The hops I am using are Warrior 15% and ended up using Cascade 5.5% as midwest was out of Amarillo. I also agree with you about the crystal malt I think I will use .25 like you suggested Could you maybe tell me how you would modify the recipe to make a true IPA?
I threw your recipe into BeerSmith then modified it how I would do it and here's what I came up with:
3.5 # Extra Light DME
.25 # Crystal 60L
.5 oz Warrior (15%) 60 minutes
.5 oz Cascade (5.5%) 15 minutes
.5 oz Cascade (5.5%) 10 minutes
.5 oz Cascade (5.5%) 5 minutes
.5 oz Cascade (5.5%) 0 minutes
Ferment with US-05
2 oz Cascade (5.5%) Dry Hop for 7 days
Awesome! Nuke, Thank you! I might have to try this next time! Im going to plug this into beersmith and save it!
Anyone else have any other advice?


text:
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text:
A transdermal therapeutic system exhibiting layered structure consists of a backing layer which is impermeable to active substances, a matrix having water-insoluble basic material and islands (inclusions) divided therein, and a layer controlling the access of cutaneous liquid by means of which the matrix is activatable. Process for the production are described.
1. A transdermal therapeutic system exhibiting a layered structure and comprising a backing layer (11) which is substantially impermeable to active substances, a matrix (12) containing the active substance in an activatable form, and a layer (13) controlling the access of cutaneous liquid, the improvement wherein the matrix (12) comprises a material (15) which is permeable to water vapour, but substantially water-insoluble, in which islands (14) are distributed which consist of a solid solution of pharmaceutical in a water-soluble or water-swellable basic material, the proportion of islands (14) to the mass of the matrix layer (12) lying between 0.5 and 70%, the matrix being activatable by cutaneous liquid.
2. The transdermal therapeutic system according to claim 1, characterized in that the portion of islands (14) to the mass of the matrix layer (12) lies between 5 and 40%.
3. The transdermal therapeutic system according to claim 1, characterized in that the particle size of the islands (14) amounts to 5 to 20 μm.
4. The transdermal therapeutic system according to claim 1, characterized in that the islands (14, 24) within the basic material (15, 25) are positioned in a plane parallel to the releasing surface.
5. The transdermal therapeutic system according to claim 1, characterized in that the basic material of the water-absorbing islands (14, 24) consists of polyvinyl alcohol, polyvinyl pyrrolidone, copolymers of polymethacrylic acid, polysaccharides, polyethylene glycol, and homogeneous mixtures of these substances.
6. The transdermal therapeutic system according to claim 1, characterized in that an active substance selected from the group consisting of antihistamines, antirheumatics, opioids, anticholinergics. antisympathotonics, steroid hormones, prostaglandins, neuroleptics, and amphetamine derivatives is used in the islands (14, 24).
7. The transdermal theraputic system according to claim 1, characterized in that the cutaneous liquid access controlling layer (13, 23) exhibits pressure-sensitive adhesive properties.
8. The transdermal therapeutic system according to claim 1, characterized in that the cutaneous liquid access controlling layer (13, 23) consists of a mixture of one or more components of polyisobutylene, aliphatic hydrocarbon resins, esters of polyacrylic acid, and silicone polymers.
9. The transdermal therapeutic system according to claim 1, characterized in that the cutaneous liquid access controlling layer (13, 23), the matrix (12, 22), or both of them comprise one or more additives which increase the permeability of the skin to the active substance.
10. The transdermal therapeutic system according to claim 1, characterized in that the layer (13, 23) controlling the access of cutaneous liquid is covered with a removable protective layer (16, 26) during storage.
11. The transdermal therapeutic system according to claim 1, characterized in that the water-insoluble basic material (15, 25) of matrix (12, 22) substantially consists of one or more components or polyisobutylene, natural or synthetic hydrocarbon resins, styrene, butadiene copolymers, polyacrylic acid esters, esters of polyvinyl alcohol, and silicone polymers.
12. The transdermal therapeutic system according to claim 8, characterized in that the cutaneous liquid access controlling layer (13, 23) consists of a mixture of one or more components of polyisobutylene, aliphatic hydrocarbon resins, esters of polyacrylic acid, and silicone polymers, and additives.
13. The transdermal therapeutic system according to claim 12, wherein the additives are resins or plasticizers.
The present invention relates to a transdermal therapeutic system exhibiting a layered structure, consisting of a backing layer which is substantially impermeable to active substances, a matrix comprising the active substance and being activatable, and a layer controlling the access of cutaneous liquid; the present invention further relates to a process for the production of such a system.
Transdermal therapeutic systems are self-adhesive galenic preparations to be applied to the skin having a fixed application surface; these preparations release a pharmaceutical to the human or animal body in a controlled way with respect to time and quantity. Such systems, e.g., have been described by Y.W. Chien, Drug Dev. Ind.Pharm. 13, 589-651 (1987), and have become well established in therapy for many years.
Usual constructions of transdermal systems already used in practice are:
a) composition comprising an impermeable carrier and a second layer simultaneously serving as drug-reservoir, pressure-sensitive adhesive and controlling unit,
b) composition comprising a carrier, drug-reservoir, controlling unit, and adhesive layer in spatial separation,
c) composition comprising a carrier and a drug-containing, multi-layer matrix, whereby the active substance concentration becomes lower from layer to layer towards the skin,
d) composition comprising a carrier and a matrix, whereby the release is controlled by drug-containing microcapsules dispersed through the matrix.
The therapeutic progress of such systems compared with traditional application forms is the fact that the active substance is not released to the body intermittently, as is the case, e.g., when taking tablets, but continuously.
In this manner, the duration of efficiency of the pharmaceutical is extended on the one hand, and on the other hand, side effects are widely prevented by avoiding unnecessary blood level peaks.
However, since the skin does not exhibit sufficient permeability to all suitable pharmaceuticals, only few active substances may be employed in transdermal therapeutic systems of common composition. Thus various tests have been conducted aiming at an increase of the natural permeability of the skin.
Such a possibility is the use of so-called "penetration intensifiers". These are substances which achieve a considerable increase of active substance flow by chemicophysical interaction with the micro-structure of the skin. Many of these substances, however, have a toxic effect to the skin and create irritations. Furthermore, the effect of these resorption promoters does not always occur rapidly enough, so that the effect is difficult to control.
Another possibility is the use of physical principles, such as, e.g., iontophoresis. These processes, however, require comparatively expensive additional devices within the transdermal therapeutic system, and thus this form of therapy is generally rendered uneconomic.
A basically different way to increase the permeability of the skin is to increase the thermodynamic activity of the active substance. Corresponding tests aimed at an increase of active substance concentration taking effect from the outside, in order to increase the permeation. These efforts were limited by the fact that, in general, the concentration of an active substance cannot be increased beyond the saturation solubility; on the other hand it did not prove to be successful to use galenic basic materials exhibiting higher solubility for the active substance in transdermal therapeutic systems, since here the connection between distribution coefficient and solubility according to the Nernst distributuion law takes effect.
Temporarily so-called supersaturated states may arise in which the dissolved active substance concentration is above the saturation concentration, e.g., when cooling a saturated solution, or when redissolving an embedded active substance in a water-soluble polymer, as is described, e.g., by Merkle, Pharm. Ind. 42, 1009-1018 (1980).
Depending on the degree of supersaturation and the viscosity of the surrounding medium this state may last from a few seconds to up to several years. In the case of adhesive polymer matrices which have a relatively low viscosity this state, in general, remains stable for a few weeks at most. The duration of the stable condition is impaired, amongst others, by the possibility that the present interfaces may act as crystallization nuclei.
The production of storable transdermal therapeutic systems comprising an supersaturated solution of the active substance therefore encouter greatest difficulties.
EP-A-0 186 019 describes that the addition of water-swellable polymers to a solution of the active substance in a basic polymeric material remarkably increases the release velocity of a transdermal therapeutic system manufactured from this mass.
In the process described, the active substance and water-swellable additive are added to the formulation of the basic mass, which is prepared in lipophilic solvents, in one process step so that an intended enrichment of the active substance in the hydrophilic domains is not possible. Addition of cutaneous liquid is effected in an uncontrolled manner.
If the supersaturated condition is created only when the pharmaceutical is already present on the skin, stability problems with respect to storage naturally arise. Coldman et al (J. Pharm. Sci. 58, 1098-1102 (1969) describe a resorption intensification of fluocinolone by solution in a mixture of volatile and non-volatile solvents, whereby on evaporation of the highly volatile component an supersaturated solution results which leads to a higher skin penetration. Kondo et al (J. Pharmacobio. Dyn. 10, 662-668 (1987) confirmed these effects with the use of nifedipine.
Accordingly, it is the object of the present invention to provide a transdermal therapeutic system exhibiting an increased active substance flow and a formulation which is stable in storage; a further object is to provide a process for the production of such a system.
According to the present invention this object was achieved by providing a transdermal therapeutic system exhibiting a layer construction consisting of a backing layer (11) which is substantially impermeable to active substances, a matrix (12) containing the active stubstance and being activatable, and a layer (13) controlling the access of cutaneous liquid. This system is characterized in that the matrix consists of a basic material (15) which is permeable to water-vapour but substantially water-insoluble and mainly free of active substance. Said basic material comprises islands (14) distributed therein, which inclusions consist of a solid pharmaceutical solution in a basic material being water-soluble or water-swellable; furthermore the system is characterized in that the matrix is activatable by cutaneous liquid whereby a controlled access of skin moisture into the matrix (12) is effected, and that the islands (14) absorb moisture so that a system-controlled, intended supersaturation with active substance takes place which results in an increased release of pharmaceutical. The object of the present invention was further achieved by a process for the production of the therapeutic system wherein the islands (14, 24) are obtained by spray drying a solution of the active substance and the moisture absorbing basic material in a suitable solvent by drying as thin layer a solution of the active substance and the moisture absorbing basic material in a suitable solvent, and by subsequent milling or by precipitation from a solution of the active substance and the moisture absorbing basic material by means of a suitable precipitation agent in which the moisture absorbing basic material is substantially insoluble. Loading of the islands (14, 24) with active substance is carried out by means of solid-liquid absorption in a suspension of unloaded islands in a suitable solvent comprising the active substance in dissolved form.
Advantageously, the matrix (12, 22) or the layer controlling the access of cutaneous liquid (13, 23) is applied to a carrier, which has been rendered dehesive, in a solution or suspension in a suitable solvent, and the solvent is subsequently removed by drying. The cutaneous liquid access controlling layer (13, 23) is liquefied by application of heat, and applied in this state to a dehesive carrier, and the matrix (12, 22), the cutaneous liquid access controlling layer (13, 23), and backing layer (11, 21) are continuously combined by application of pressure and/or temperature. The matrix (22) is formed by separate manufacture of two identical layers of basic material (25), optionally having a different layer thickness, sprinkling the islands (24) on one of the two layers, and subsequent application of the second layer of basic material (25) under application of pressure and/or temperature.
Suitable active substances can be selected from the active substance groups consisting of parasympathicolytics (e.g., scopolamine, atropine, benactyzine), cholinergics (e.g., physostigmine, nicotine), neuroleptics (e.g., chlorpromazine, haloperidol), monoamine oxidase inhibitors (e.g., tranylcypromine, selegiline), sympathomimetics (e.g., ephedrine, D-norpseudoephedrine, salbutamol, fenfluramine), adrenergic blockers and anticympathotonics (e.g., propanolol, timolol, bupranolol, clonidine, dihydroergotamine, naphazoline), anxiolytics (e.g., diazepam, triazolam), local anesthetics (e.g., lidocaine), central analgesics (e.g., fentanyl, sufentanil), antirheumatics (e.g., indomethacin, piroxicam, lornoxicam), coronary pharmaceuticals (e.g., glycerol trinitrate, isosorbide dinitrate), estrogens, progestins, and androgens, antihistamines (e.g., diphenhydramine, clemastine, terfenadine), prostaglandin derivatives, vitamins (e.g., vitamin E, cholecalciferol), and antitumor agents. Furthermore, other active substances are suitable for the purpose according to the present invention, if they exhibit a therapeutic daily dosage of less than 50 mg and are soluble both in water and in organic solvents.
As components in the basic material (15, 25) of the matrix (12, 22) polymers may be used, e.g., polyisobutylene, ester of polyvinyl alcohol, polyacrylic and polymethacrylic acid esters, natural rubber, polymers of styrene, isoprene, and styrene-butadiene or silicone polymers, resin components, such as, saturated and unsaturated hydrocarbon resins, derivatives of abietyl alcohol and of β-pinene, plasticizers, such as phthalic acid esters, triglycerides and fatty acids, as well as a series of other substances known to those skilled in the art.
A variety of pharmaceutical auxiliaries which are swellable in water, such as, e.g., polyvinyl pyrrolidone, polyacrylic acid, polyvinyl alcohol, cellulose and its derivatives, naturally occurring slime formers, e.g., agar (agar), guar gum, and gum arabic, but as well inorganic materials, such as kaolin or bentonite are suitable components for the base material of the islands (14, 24).
In the case of the layer on the skin side (13, 23), which controls the moisture access to the matrix, the choice of the thickness and the materials used are of particular importance, since both factors together considerably determine the course of swelling of the islands (14, 24), which is caused by moisture absorption, and thus determine the degree of supersaturation. If the access of cutaneous liquid takes place too rapidly, the supersaturation within the islands (inclusions) is effected too fast and too high, so that precipitation of the active substance and thus falling-down of the release rate to the saturation-flow-level would result. If the moisture diffuses too slowly into the matrix, the supersaturated state is created too late, and the release potential within the islands is not utilized in an optimal manner.
Suitable basic polymers for moisture access controlling layer (13, 23), e.g., are polyacrylic acid ester and polymethacrylic acid ester, polyvinyl alcohol and the esters thereof, polyisobutylene, or polyethylene. It is not necessary that the moisture access is controlled by the diffusivity of the material used--it is possible, too, that the access is controlled by the porosity of the material used. The moisture access can also be controlled by the addition of inert, powdery charges, e.g., talcum, quartz powder, activated carbon, etc.
By way of selective choice of the basic polymer or by suitable additives, e.g., resins and plasticizers, the moisture access controlling layer (13, 23) can be rendered pressure-sensitive adhesive, according to a particular embodiment of the present invention.
The process for the production of such systems can be carried out in different ways.
In the manufacture of the islands (14, 24), complete dissolution of the active substance in the basic material must be taken care of, so that no crystal nuclei are brought into the formulation of the pharmaceutical.
Thus preferred processes are those where common dissolution of active substance and auxiliaries in adequate solvents and subsequent drying takes place.
In this connection, the process of spray drying is particularly preferred, in which a drying process and a size-reduction process are combined so that the desired particles are obtained in one process step. However, it is possible, too, to spread the solution of active substance and auxiliary agents on metal rolls or dehesive carriers, to dry the solution as such a thin layer, and subsequently subject it to dry-milling according to processes known to the man skilled in the art.
In another suitable alternative, a precipitation agent is added to the solution of active substance and auxiliaries, said precipitation agent leading to a particulate precipitation of at least part of the auxiliaries. In this process dissolved active substance is retained in the particles of the basic materials. The particles are dried subsequent to separation of the particles by filtration, classifying, wet screening, or another process suitable for this purpose.
If the basic material is present in an adequate grain size distribution even prior to the production, it is possible, too, to disperse these particles in a solution of the active substance, and thus achieve a saturation of the basic material with active substance by absorption. In this case, too, a drying process (e.g., tray drying or fluid-bed drying) has to follow the separation process, e.g., filtration, screening, classifying, etc., in order to create islands (14, 24) according to the present invention.
The grain size of the islands should always be smaller than the intended thickness of matrix (12, 22). Considerably smaller grain sizes are preferred, since separation into as much individual compartments as possible can effectively prevent the development of possible crystallizations during wearing of the system.
For this reason particle sizes of maximal 5 to 20 μm are preferred, particularly preferred are those below 5 μm.
The active substance portion of the island base material typically is 5 to 50% below the saturation solubility of the active substance in the dry basic material. In case of particularly brittle, glass-like basic materials, the saturation solubility may even be exceeded by up to approximately 300%, since in the case of these basic materials crystallization occurs at an extreme delay.
In order to manufacture the matrix layer, the basic material can be dissolved in a solvent, in which the basic material of the islands is insoluble, and the particles dispersed therein. Such a suspension, preferably in a coating device, is applied on a carrier which has been rendered dehesive and on which the matrix layer is solidified, e.g., by drying in hot-air stream. Solvents suitable for this purpose are mixtures of benzene having adequate boiling ranges, toluene, methylene chloride, and many other lipiphilic, readily volatile substances which do not considerably influence the structure of the hydrophilic islands.
In case of sufficiently temperature-resistant active substances solvent-free processes are particularly suitable. For example, the basic material (15) may be brought into a spreadable condition by the application of shear force and heat, the necessary amount of islands may be kneaded or mixed in, and the mass, after application to a dehesive carrier, may then be cooled.
Both the solvent process and the melting process are suitable processes for the production of the layer controlling the access of cutaneous liquid (13, 23).
According to a particular embodiment of the present invention at first two layers of basic material are produced according to one of the beforementioned processes--however, free of islands first.
Both layers consist of the same material, however, do not necessarily exhibit the same thickness. The spreadable, particulate islands (always having the same surface load) are sprinkled homogeneously. Subsequently, the second part of the matrix layer is laminated thereon by rolling under pressure. If necessary, the process can be accelerated by the application of heat.
The portion of island material (basic material and active substance) to the matrix mainly depends on the amount of active substance in the basic material of the islands, the thickness of the matrix layer, and the required active substance load of the transdermal therapeutic system per area unit. In general, an amount between 0.5 and 70%, preferably between 5 and 40% is aimed at.
The combination of matrix and the cutaneous liquid access controlling layer suitably is carried out in a lamination device in which both layers can be brought to continuous adhesion by the application of pressure. If necessary, heat may be applied in order to intensify and accelerate this process.
The finished system may be covered with an adhesive cover.
Cutting or punching into desired geometric forms and sizes in the first place is carried out according to the therapeutic requirements, e.g., intended daily dosage, permeability of the skin, and degree of flexion of the skin area to be covered.
Particularly suitable as packing are multi-layered primary packings serving as barrier to water vapour, e.g., made of a polyethylene copolymer/aluminum/paper-composite.
The composition of the transdermal therapeutic system according to the present invention is illustrated by FIGS. 1 and 2.
FIG. 1: (11) backing layer;
(12) matrix with islands (inclusions);
(13) layer facing the skin and controlling the access of cutaneous liquid;
(14) active substance containing islands.
(15) basic material of matrix;
(16) removable protective layer;
FIG. 2: (21) backing layer;
(22) matrix comprising arrangement of islands parallel to the releasing surface;
(23) layer facing the skin and controlling the access of cutaneous liquid;
(24) active substance containing islands, positioned in a plane;
(25) basic material of matrix, combined of two layers;
(26) removable protective layer.
The invention is further illustrated but not limited by the following examples:
250 mg haloperidol are completely dissolved in 25 g ethyl acetate in a 100-ml-beaker provided with magnetic stirring rod. Subsequently, 5 g cross-linked polyvinyl pyrrolidone (maximum grain size 150 micro meters) are added slowly, and the suspension is stirred for 2 hours at 22� C. The swollen particles together with the adhering solvent are dried for one hour as thin layer on a siliconized polyester foil at 80� C. in a fresh-air-drying oven.
4.3 g of the thus obtained powdery embedding (comprising 205 mg haloperidol and 4095 mg polyvinyl pyrrolidone)
10.0 g heat-vulcanizable dimethylpolysiloxane and
3.2 g benzine
are unified under slow stirring until an optically homogeneous mass results, thereby avoiding incorporation of air-bubbles. The mass is coated by means of a film applicator (gap 300 micro meters) on a polyester carrier of 25 μm thickness, cross-linked for half an hour at a temperature of 80� C. and simultaneously dried. The polymerized layer is subsequently again covered with a commercially available silicone adhesive mass by means of a film applicator (gap 100 micro meters). The final drying is effected unclosed at room temperature within 30 minutes, and subsequently in the drying oven at 50� C. for 10 minutes.
0.205 g haloperidol
4.095 g cross-linked polyvinyl pyrrolidone
10.0 g heat-vulcanizable dimethylpolysiloxane and
3.2 g benzine
are unified under slow stirring until an optically homogeneous mass without air-bubbles results. Further processing (coating, cross-linking, covering with silicone adhesive mass, drying) is conducted as described in example 1.
Circular pieces of the formulations according to examples 1 and 2 (surface 2.54 cm2) are bonded centrally on a piece of excised hairless mice skin. The skin pieces are fit in a permeation apparatus, the basic construction of which is described by Kondo et al, J. Pharmacobio.-Dyn. 10, 662-668 (1987). As acceptor solution the cell used contained a phosphate buffer of a pH-value of 5.5 and was thermostatted to 37.0� C. over a tempering jacket.
The determination of the released haloperidol amount was carried out by high pressure liquid chromatography (reverse phase, detection UV at 242 nm).
The following results were obtained
______________________________________ amount of haloperidol (μg) (on 2.54 cm2)Example released within 24 hours______________________________________1 682 36______________________________________
By the composition according to the present invention according to example 1 a considerably higher skin permeation is achieved compared to that according to comparison example 2.
It is understood that the specification and examples are illustrative but not limitative of the present invention and that other embodiments within the spirit and scope of the invention will suggest themselves to those skilled in the art.
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4:42 pm
Tue May 22, 2012
Exoneration List Shows Patterns In False Convictions
Originally published on Tue May 22, 2012 5:50 pm
While we assume our judicial system occasionally makes mistakes, until recently no one had been tracking the number people in this country who are convicted and later exonerated. Now the National Registry of Exonerations has begun compiling these cases. Audie Cornish talks with the registry's editor, Samuel Gross, about some of the group's findings from the over 2,000 exonerations they've compiled.


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Final Fantasy Type-0 HD is finally available and the official collector's edition available only from the Japanese Square Enix Store is a little different than the European and North American versions. Dubbed the "Ultimate Box," it includes the following for 19,440 yen:
- Special box design
- Soundtrack CD (16 tracks)
- Calendar
- ID card
- Ace's card set (five cards)
- Scarf
Also included obviously are the game and Final Fantasy XV Duscae Demo. I received the PS4 version of the Ultimate Box and filmed a little video showing off the goodies you can watch below.
And if anyone is interested, here is the track list of the soundtrack. It's just a small fraction of the all the songs off the full soundtrack plus a few from Final Fantasy Agito.
- 我ら来たれり
- 導かれる結論
- クリスタルの使徒
- マキナ・クナギリ
- レム・トミキヤ
- 戦-弩級の響き
- 戦-静かな激闘
- 朱雀の炎
- 零式
- Forbidden Fruit
- マイ ダイアモンド
- My Diamond
- カラフルフォーリンラブ
If you are excited at all about the long time arrival of an English version of Final Fantasy Type-0 and want to learn more about the interesting history and people who worked on this game, I recommend reading this fan composed digital magazine. Along with a whole lot of talented fans working together, I contributed an article regarding the manga and novels that are based on this series.
Check it out below or download it here.


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See "The Steve Malzberg Show" on Newsmax TV each weekday live by clicking here now.
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Massachusetts Democratic Sen. Elizabeth Warren gave her strongest statement to date about her plans for a 2016 president . . .
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Tuesday, 31 Mar 2015 11:29 AM
As Holy Week begins, Catholic dioceses in Italy's organized crime ridden regions are following Pope Francis' admonitions . . .
This serial criminal, like at least half the Democrat Party, belongs in federal...
Another disgusting betrayal of an ally by this Administration -- driven solely...
I don't feel anyone should be denied a seat at the Lunch counter..
But I do...
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British sprint canoeist Paul Wycherley kayaked across the English Channel in a new record time on October 2, beating the mark set by his coach Ian Wynne, says BBC. Wynne, a bronze medallist at the Athens Olympics in 2004, had crossed it in two hours and 59 minutes in 2007. Wycherley took two hours and 28 minutes. "I got quite sore near the end but I'm chuffed to bits and I got a really good time," Wycherley told the media. "It's October so you could expect wind and a lot of swell, but we had a really calm day. "A few people asked me if [crossing the Channel] is what I needed to be doing before 2012 [the Olympics], and simply the answer is yes."
Watch these links:
Destination 2012 - Paul Wycherley Interview
Cross Channel Challenge Promo Video
Keywords: Paul Wycherley, English Channel


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Dr. Angela F. Thibodeaux and our team are committed to bringing you and your pets better health by practicing the science of Veterinary Medicine. Statham based Four Paws Animal Hospital was founded in 2005. Since then our staff has been performing veterinary medicine and compassionate animal care in
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A Wealth of Veterinary Experience at Your Service! At VCA Animal Hospital, we look forward to welcoming you, your dog, cat and other pets. Everyone on our staff believes that the better we get to know your pets, the better we can provide the best possible health care for them. In fact, when you
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A great local veterinarian loves your pet (almost) as much as you do by providing the best preventive pet health care. From nose-to-tail veterinary medical exams to vaccinations, microchipping, dental care and surgery, you'll find the vet your pet deserves at your neighborhood Banfield Pet
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A great local veterinarian loves your pet (almost) as much as you do by providing the best preventive pet health care. From nose-to-tail veterinary medical exams to vaccinations, microchipping, dental care and surgery, you'll find the vet your pet deserves at your neighborhood Banfield Petview deal
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Shane Finley
PROVO — When Amelia Draney touched the wall to finish the 500-yard freestyle during the second day of the 3A state swim meet at BYU on Saturday morning, the near-capacity crowd erupted.
With a time of 4:59.38, the Desert Hills junior lapped every other swimmer in the pool en route to breaking her own 3A record by over three seconds, which she set almost exactly a year ago.
"I just was looking at the clock and saw I was under five minutes and I thought, 'just keep going. Hold on as long as you can,'" said Draney, who was named the 3A female swimmer of the year by the Utah Swim Coaches Association.
"I've just learned to pace myself," Draney said when asked about her 34-second victory. "Just how everyone says, you've got to be better than you were yesterday. That's what I'm out there doing."
The state record for the 500 free is 4:56.97, a number the Southern Utah swimmer said is imprinted in her mind.
"It will be there next year. I'm working for it," she said.
Draney was also a crucial piece in Desert Hills' victory in the 400-yard freestyle relay as she anchored the 3:48.22 victory swim. The rest of the relay team included junior Tessa Trimble, junior Madison Wawrzyniak and sophomore Zoe Smith.
Mitchell Hutchings, the 3A male swimmer of the year, also came from the southern end of the state, representing Pine View on the podium with his first-place finish in the boys 500 free.
"Me and my coach have been working on trying to control the adrenaline through the race," said the junior, who finished with a time of 4:51.43. "He told me after the 300 mark to build it up and let it loose, and that's exactly what I did."
Tressa Trimble, a Desert Hills junior, and Brandon Johnson, a Tooele senior, started off the final day of competition with victories in the 100-yard butterfly. The former did so with a time of 1:00.67 and the latter finished in 53.80 seconds.
The 100 free champions were McKenzie Barber, a senior from Snow Canyon, and Bryce Mounteer, a senior from Wasatch.
"I haven't been dropping any time this whole year in my 100 free," Barber, who shaved nearly half a second for a time of 54.06 seconds, said. "It was really discouraging for a while, but it was nice to finally do it at state."
In addition to the 100 free, which Mounteer won with a time of 49.57, the sprinter added to the Wasatch team score with legs in the 200-yard freestyle relay and the 400-yard freestyle relay.
"We made some changes last week and I told the boys, 'I think we can win all three relays,'" said Wasatch coach Steve Marsing, referring also to the medley relay that took place on Friday. "We set all school records in all three relays and took first in all three relays."
The Wasps' 400 free relay time was 3:20.00 and included David Finley, Mounteer, Tolbert and Hunter Hallows.
The 200 free relay team was made up of seniors Sam England, Mounteer, Hunter Tolbert and Brady Winward. They finished in 1:29.97, just 0.48 seconds off the 3A record.
The Wasatch girls 200 free relay team — made up of sophomore Phebe James, senior Rachel Low, junior Megan Mounteer and junior Anna Dahl — also won. They did so with a time of 1:41.39 and were just 0.43 seconds shy of the 3A record.
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text: Funny Friday [VIDEO] – Kirby Puckett On David Letterman By Jen Jacobs March 4, 2011 6:00 AM Share on Facebook Share on Twitter Getty Images Twins legend Kirby Puckett made an appearance on David Letterman and presented the Top 10 List. Kirby Puckett died on March 6, 2006. Touch 'em all, Kirby Puckett! Touch 'em all. Category: Feel Good, Funny Friday Video, Morning MIX, Videos Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of Mix 94.9 Recommended For You Around the Web


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product details-Tab
A topical cream clinically proven to relieve foot discomfort associated with cold feet.
Made in the USA
Keep out of reach of children. For external use only. If swallowed, contact a Poison Control Center. Do not use on open wounds. Avoid contact with eyes or other mucus membranes. If contact occurs, rinse thoroughly with water. Close cap after use. Store at room temperature.
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Excellent product Does as it says
By KM
from Atlanta, Ga
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Comments about Healthifeet Foot Cream, 4 oz:
This product did as promised. I am happy to say that healthifeet has successfully aided in the healing and maintaining of my now happy feet. They suffered dry scaling (even cracking), tingling, sore and tired feet. I shall continue this product and certainly recommend it to those in need.
Bottom Line Yes, I would recommend this to a friend
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(1 of 1 customers found this review helpful)
Works very well
By Jim
from Indianapolis
describe yourself Novice First Aid Skills
I use the product daily. I have noted an increase in blood flow to my feet and a decrease in tingling.
(6 of 6 customers found this review helpful)
I would buy this product again and again
By TERI
from Chickasha, Ok
describe yourself Parent
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Healthifeet is a product that has worked like the product says it does. I have been using this product for 2 weeks. My cold, numb feet feel better at night and I can sleep. **Note: I also put on a pair of socks after rubbing it in. I was listening to "The Doctors" and they had an audience member volunteer and she had the same feet symptoms I have. It was worth the try.
(2 of 2 customers found this review helpful)
"Healthifeet" has helped me tremendously. I discovered it when I watched "The Doctor's." My feet does not have the cold, numbness feeling. I would recommend this to anyone that has neuropathy.
(4 of 4 customers found this review helpful)
I would buy this product again.
By Peggy
from IL
It's very soothing. The five minutes to rub in seems excessive.
(5 of 5 customers found this review helpful)
Excellent product
By BBG who refuses to give in to pain !
from Connecticut
this product does just what it claims if used as directed everyday. The only product I have ever found to stop the numbness and tingling. Easy to use and non-greasy. The only reason I am not giving it 5 stars is that the warmth does not last 24 hours when used once per day. Began using in summer months, and am waiting to see results when the weather is cold.
Works great!
By Jen
from NY
Hubby has diabetes and this cream worked wonders for his neuropathy. Highly recommended!
(9 of 10 customers found this review helpful)
Neuropathy and Healthifeet Cream
By cjwilgus
from Indiana
describe yourself Diabetic
After only 2 years of peripheral neuropathy, I thought I would never find a product that soothes and even lessens the symptoms I have been feeling: cold feet, numbness, tingling, shooting pain, etc. But this cream actually works. Follow the directions then wait for results.
Simply rub cream into feet for five minutes, liberally covering the entire foot, top and bottom. Apply the cream twice daily, morning and evening, for seven days and then once daily to maintain soft, healthy feet.