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Latest press releases
- MOVANTIK™ (naloxegol) tablets for the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain launched in the US
- 31 March 2015
- BRILINTA receives US FDA approval for new administration option
- 30 March 2015
- AstraZeneca announces positive Phase III top-line results for PT003 from the PINNACLE 1 and PINNACLE 2 studies in COPD
- 18 March 2015
- PEGASUS-TIMI 54 study shows that long-term treatment with BRILINTA reduced thrombotic cardiovascular events in patients with a history of heart attack
- 14 March 2015
- AstraZeneca PLC fourth quarter and full year results 2014
- 5 February 2015
- PEGASUS-TIMI 54 study of BRILINTA® meets primary endpoint in both 60mg and 90mg doses
- 14 January 2015
- LYNPARZA™ approved by the US Food and Drug Administration for the treatment of advanced ovarian cancer in patients with germline BRCA-mutations
- 19 December 2014
- FASLODEX® (fulvestrant) significantly improves overall survival for women with hormone-receptor positive breast cancer compared to ARIMIDEX® (anastrozole)
- 12 December 2014
- AstraZeneca announces plans to expand its Frederick, Maryland biologics manufacturing center
- 21 November 2014
AstraZeneca tweets
AZ employees greeted @RepScottPeters (left) at our Ardea Biosciences site today in #SanDiego. Thanks for visiting! http://t.co/sH3ChfBqM28 hours ago
AZ welcomes @RepScottPeters to visit our Ardea Biosciences site in #SanDiego today.12 hours ago
RT @ACCinTouch: Fairview Hospital Cleveland Clinic Health System in OH is kick starting the #ACCPatientNavigator Program this afternoon15 hours ago
Thanks to all who made #MDBiotech15 & #LOTS15 possible! With continued collaboration MD/DC/VA will become a national biotech leader.31 Mar
RT @MedImmune: Congrats to the DiaQuest team for taking first place in the #LOTS15 Idea Challenge for its AllergySure solution! http://t.co…31 Mar


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Most of us are perpetually looking for new contacts to add to our subscriber lists. It's part of life as a modern marketer. The average email list churns by about 30 percent every year, so we have to constantly be on the lookout for new and innovative ways to fill that funnel.
The good news is, every page on your site is full of opportunities to engage your visitors and convince them to join your list. The bad news is, most visitors don't spend much time on a web page – in fact, 55% spend 15 seconds or less on your site.
So, how can you make the most of those 15 seconds? Here are five simple tweaks to optimize your signup form – and convert more clicks.
Tweak #1: Shine a spotlight on your call to action.
Keep the call to action in the visitor's line of sight as long as possible. One of the easiest ways to do this is to use a lightbox to add the form to a sticky header or footer and keep it on screen at all times.
I know – lightboxes (also known as pop-ups) aren't universally loved. Some marketers believe they degrade the brand. Others feel they degrade the user experience. Others just think they're ugly.
Fact is, when it comes to attracting new subscribers, lightboxes are a tried-and-true tactic. They work because they make it easy for visitors to find your form – and to join your list.
If you're still on the fence, consider this: Amazon uses a similar method to keep the "Add to Cart" button on screen. By keeping the button on screen at all times, the visitor can add the product to their cart at any time without having to scroll all the way back to the top of the page, making it far more likely that the visitor will make a purchase.
Also: Be specific. A generic "contact us" message isn't going to yield the same results as a more specific CTA. Think about your key messages. If you're trying to raise funds for your food pantry, your CTA might be, "Help feed the hungry." If you are pushing a new ebook, try "Get the inside scoop now." A CTA directly related to the content you're offering will always generate better results.
Tweak #2: Pique visitor interest by adding video.
Video is a must-have for marketers for many reasons. First, it boosts awareness: Videos increase people's understanding of your product or service by 74%. It also is a powerful conversion tool. Website visitors are 64% more likely to buy a product on an online retail site after watching a video.
Video's also one of the best ways to keep guests on your site for longer than the aforementioned 15 seconds. If you have a video on your page, position your opt-in right under it. Or, use a lightbox to ask people to join before they view. By tying your signup to a video that already has the visitor's attention, you'll increase the chances that they'll sign up for your list.
Tweak #3: Relocate your form to prime real estate.
Many company websites corral links in footers for the sake of design. It looks clean – but it can lead to many missed opt-in opportunities. Put your signup form at the top of your home page alongside some other engaging content. You'll get the most eyeballs possible on your form without requiring site visitors to scroll all the way down to the bottom.
Tweak #4: Encourage engagement with interactive elements.
Keep your audience captivated by adding engaging elements to your form, like an animated gif.
Another tactic? Switch up the look and feel of your opt-in to make it look more like a live chat box. Ask the user a question like, "Hi, I'm Emily – want to learn more about our product?" This also provides a great opportunity for A/B testing. Craft several copy options, and rotate various questions until you find the one that best resonates with your target audience.
Tweak #5: Modify it for mobile.
Today, it's absolutely critical to optimize your forms for mobile – 80% of Internet searches are made on a smartphone, and 47% are logged from a tablet. With that in mind, your sign-up forms should be built with a smaller screen and ease of scrolling in mind. Instead of putting a bunch of fields on your form, limit it to one or two fields and add a big call to action button. This allows visitors to join your list with the tap of a button.
Christopher Lester is the vice president of sales at Emma where he leads the team of experts who provide strategic and tactical services to all Emma clients, as well as specialized support to large senders and significant brands.

subset: commoncrawl


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Finally! A plant that LOVES it here.
It is a very beautiful day in Hercules; I doubt anyone is inside when they could be out. I'm working on centerpieces for my good friend's 60th birthday party. I took a break and looked around outside. Can someone please give me the scientific name of this succulent? I love the blue leaves. It is getting a bit out of control and I want to divide it. Should I place in water to root? Or just cut it and put it in the dirt? Or what? I could look this up myself but I like hearing from others.
Is it in the ice plant family?
Thanks! Marlene
Oh, I have that one too. I think it's called "Fingers." I planted it on my dry, rocky bank and it actually likes it there and our frosty nights didn't discourage it either. I planted yellow Gazania in with it, which looks pretty with the blue. I have broken off pieces, let them heal for a couple days, then just stick in dirt and water a bit until they take hold.


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Marketplace Morning Report
Start your day with an up-to-the-minute report on the world of business and finance with host David Brancaccio.
Recent Episodes
05-23-14 Mid-day Update - Can London always be a world finance capital?
Can London hang on to its position as the heart of the global economy?
05-22-14 Mid-day Update - The economy in Uighur China
Today's attack on a market in Xinjiang killed 31. A look at Scottish independence.
PODCAST: A cautious Fed
A visit the 100 year-old Borough Market in London. And a look at London's lost title as the top financial city in the world.
PODCAST: London's stock ambitions
A look at Brixton Market, in South London. And there's a clamor about high executive pay in the UK.
PODCAST: AT&T bids $48.5 billion for DirecTV
We visit Smithfield Market in London. And a look at London's business environment.
05-16-14 Mid-day Update: Some (temporary) relief at the pump
Gas prices are leveling off. A new rail line in London. TV's upfronts.


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OP Junior Member
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Join Date:Joined: Jun 2014
I've been lurking around these forums trying to find a solution to a few problems that my HTC One M7 has been having but have yet to find a solution.
It all started with the black screen problem where I could only see the screen on my phone by shinning a bright light on it. I decided to do a factory reset but that didn't fix the problem.
My next step was taking the back housing off my phone to see if any of the flex cable connections were loose. Since I've been tinkering around inside I've gotten some weird versions of different things to happen.
I've gotten the screen to be back to normal brightness without touch controls and I've gotten the phone to be completely working outside of sound. Right now I have all the flex cables and black antenna cable unplugged and decided to let the battery drain completely before I reseat all the cables, recharge, and try from scratch.
Just wondering if anyone has any ideas on some solutions to the problem or things I can try. I've also though about replacing some of the flex cables to see if that helps. Thoughts?


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Town Square
Another lackluster performance by the Foothill Hs X Country Coach
Original post made by Bernard Laffer, Pheasant Ridge, on Oct 12, 2012
Comments (1)
a resident of Oak Tree Acres
on Oct 16, 2012 at 3:52 pm
I find the author to be a condescending jerk. Unless you are willing to step up and be the coach or help, dont complain about the job the current coach is doing. Who are you to evaluate the coaches qualifications. And stop reliving your glory days....it was much easirr to get into ivy league schools 22 years ago on a sports scholarship...if you are really so concerned, make the time and become the head coach.
How do you explain fhs domination over avhs in football? Are you ready to put down the coach and the players?
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Another bad idea from the air board
By Tim Hunt | 19 comments | 1,204 views
Exchange Club Meeting on First Amendment
By Roz Rogoff | 0 comments | 578 views


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Summer Blues table
I'm feeling a little blue about summer coming to an end. The nights are already cooling down so much and fall is definitely in the air, : ( so I set a table with some blue plaid plates from the thrift store.
The white chargers, plates, tablecloth, napkins, flatware, napkin rings, candleholders, candles, and blue/white bowl are TS treasures.
The blue goblets and silk flowers are DT, and the ceramic ducks are so old I don't remember where I bought them.
I know I should be busting out the fall decor, but I am in serious denial right now.
Anyhow, the table is blue, but fun enough that I am a little bit happier, I guess. LOL
Beautiful table!!! I know what you are saying about fall getting here too quick, where did summer go? Maybe it was like a shooting star, so hot it just burned its self out. I love those plaid dishes and the green napkins pull the green leaves out so good. You do find the greatest things at your thrift stores.
tfs Janet
Awww Candy, I'm sorry you are feeling so blue. But that is sure a pretty, and summery, table. Definitely a "feel good" one. Makes me think of summer on a farm, and that is definitely a happy thought.
I wish summer had lasted longer for a lot of you, especially with such a tough winter not that many months ago. It seems kind of unfair. (hope y'all can forgive me for thinking "Hurry Fall" tho. My summers are like your winters, I'm stuck inside most of the time and longing for nice days again.)
We need to have one of those RV Caravans and travel around the country and always be some place with nice weather so we can play and shop and have fun together. Janey's bus just isn't big enough I'm afraid. LOL
hugs, Karen
Candy this is such a lovely table! The plaid dishes with the floral pattern are so pretty along with the blue stems and candleholders...The tablecloth is a perfect backdrop! Love the touches of yellow & green, and the cute Ducks surrounding your CP.
I agree...it's so hard to give up Summer...
We hardly had a Spring, and I think we all remember what a horrible long winter we had and are shuddering thinking of this Winter.
The trees here are already turning..and I'm just NOT READY to say 'Goodbye Summer' !!
Candy, this is a pretty table to bring our summer closer to the end. I too love the plaids together on this one. No wonder you used your ducks around the cp. tThey match your cute napkin rings!
So glad you set another great table to share with us.
Very cute, candy! Love those plaid dishes w/the plaids in the t'cloth!.,..ummm, perfect! And those ducks you added, just cry, 'country!' I also like how you pulled the 'green' out of the plates & t'scloth w/your napkins...looks great! A fun table, not feeling 'blue' at all! TFS! Jeanne S. (
I got 6 light colored denim placesmats today for $6 for all...we're on vacation on a lake in MN but drove to town today for some shopping...fun!) Now the Fall weather is settling in but been 80's here for almost a wk...such is life, uh? Fall must come.
It is still warm here in NY. If you saw the 9/11 ceremonies you could see everyone was in summer clothes. Lots of people down the beach today swimming, so it is still summer!
I love blue and yellow together, and this table is just wonderful! Great cloth and plates!
Candy, thank you for sharing this pretty table. It makes me feel the warm breezes of late summer.
The plaid dishes and tablecloth were made for each other.You always find the best things for your tables.
Love the ducks! Using the green napkins is the perfect touch.
I feel blue that summer is coming to and end too, but your table helped to cheer me up.
Love that pretty tablecloth and your pretty dishes just pop. That "candy shot" is fantastic! I've said it before, but it bears repeating, you have a real knack for finding bargains that go so well together--the napkins, candle holders, candles, bowl,--well, just all of it really went together to make a pretty tablescape.
It was too hot here for a couple weeks, and the heat just zaps what little energy I do have, so I'm glad it is now cooling off a bit too. Not any signs of fall here so far except in the magazines I've been reading! LOL


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SPAC Announces 2014 Residency Of Philadelphia Orchestra
Saratoga Performing Arts Center in Saratoga Springs has announced the 2014 residency of the Philadelphia Orchestra.
The residency will run from August 6 through 23rd. The lineup will include known guest conductors, premieres and pops performances. Highlights will include appearances by conductor Yannick Nézet-Séguin, Music Director of The Philadelphia Orchestra; the New York premiere of composer Tan Dun's Nu Shu: The Secret Songs of Women, a multi-media work featuring Principal Harp Elizabeth Hainen; and classical musicians Itzhak Perlman, Yo-Yo Ma, Jeremy Denk and Alison Balsom. Guest conductors will include Bramwell Tovey, Cristian Macelaru, Steven Reineke and Stéphane Denève. The seventeen day residency will also feature an American Songbook opening night, and a Broadway Extravaganza with Tony Award nominees Stephanie Block and Andrew Rannells. For more visit SPAC.org
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"Hi there VT members!" Sematay's Profile
I took this picture in Limburg where we stopped to eat lunch driving from the Black Forest to Duesseldorf, thought it would a great way for me to introduce myself to the VT community. I was born in the US, but my family is German and I have dual citizenship. Lived outside of Munich for 3 and a half years when I was young, it was my parent's goal to show me as much of Europe as possible while we were there. I experienced the roads of the former Yugoslavia on the way to Greece. I was out of school traveling so much during that time that one teacher wrote on my report card, "she would do a lot better on her coursework if she was actually in class". Traveling is educational right? In college, lived in Hamburg for a year and interned with a very dynamic Italian/German Interior Architect. I spent most summers of my childhood traveling between Duesseldorf and the Black Forest, both of my parents independently escaped from former East Germany and I was able to visit before the wall came down.
My mom decided she wanted to go to Amish country in Pennsylvania. Seeing that she just completed chemo and is a breast cancer survivor, noone was going to argue with her. :-) The pic is of the countryside and an Amish family's laundry - we don't see many laundry lines up here in the city. So peaceful....
Well, actually it was a business trip to Bellevue, but I snuck out early on my last day to take in the market in Seattle. They threw fish over my head, and I found a great place to have sushi. Didn't get to visit the space needle or the monorail, but I'll save that for next year.
Slightly past cherry blossom season and right before it got really warm, but there is so much to see there. Got to see Kermit the frog, and finally saw some Pandas!!! All my life although I have traveled all over Europe and part of the US, I have always missed the Pandas. It seems they knew I was coming and put on quite a show...
Comments (14)
Have a great birthday!!!
Happy birthday Corie.
Hope you had a nice day :)
Happy Birthday Corie!
Felicidades. Sorry for tardiness. Wishing you the best.
Corie, I hope you had a wonderful birthday!
Hello Corie, nice meeting you in today's birthday list. Happy birthday and best wishes to you to keep travelling interest, years and years. Greeting from Malaysia.
Happy Birthday Corie and greetings from snowy Finland!
Hi, sorry I missed your birthday. I hope you had a good one. :)
Happy birthday Corie!
May you have all the joy your heart can hold,
All the smiles a day can bring,
All the blessings a life can unfold,
May you have Gods best in everything.
Wish You a Happy Birthday
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text: IAB releases ad-view specification Published on March 19, 2013. 0 Reprints Reprints Ad Age LookBook Weekly Feature An Ad Tech Glossary: Must-Know Terms, If You're Looking for An Ad-Tech Partner Learn more New York—The Interactive Advertising Bureau has introduced SafeFrame 1.0, a technical specification that allows advertisers to know when a digital ad is viewable. "The release of SafeFrame 1.0 will allow us to actually see if an ad is viewable, in most cases," said Sherrill Mane, IAB senior VP-research, analytics and measurement, in a statement. "This technical specification helps to resolve a major impediment in our ability to drive the interactive advertising industry towards a digital measurement paradigm that addresses needs of marketers, agencies and publishers in a cross-platform world." IAB is simultaneously releasing an open-source reference implementation of the SafeFrame 1.0 specification that will help companies adopt the new technology, reducing time to market and associated development costs. In this article: BtoB Advertisement Read These Next Tumblr's First CMO Stephanie Dolgins Will Also Oversee Its Media Deals Tim Peterson on 03.30.2015 101 0 Chevy Liked Its Truck Effort So Much, It's Taking It National Mike Colias on 03.30.2015 61 1 L'Oreal's Chief Digital Officer on Programmatic Plans, Startups and Org Charts Jack Neff on 03.30.2015 585 0 Comments (0)


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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
Crestone Vacation Rentals Show this location only Back to top
$125 - $140 per night 2 night min stay
From $275/nt or $1750/wk
$165 per night 2 night min stay
$100 - $125 per night 2 night min stay
$145 per night 2 night min stay
$100 - $110 per night 2 night min stay
$80 - $90 per night 2 night min stay
$100 - $125 per night 2 night min stay
$175 per night 2 night min stay
Recent Crestone reviews
"My husband and I very much enjoyed staying at this casita in Crestone. It was our first time to Crestone, and in large part due to this property, it won't be our last! The home is warm, inviting, and well-cared for. It is beautiful in its simplicity, and the decor is well matched to the home - muted tones, clean lines, and no clutter. Very tranquil. Some nice features are a well-equipped kitchen, radiant heat in the polished cement floors, and a shower with a large window looking out onto the property and the mountains beyond. There is also a beautiful wood-burning stove, stocked with plenty of wood. The property is secluded and silent. The only "neighbor" we saw were the mule deer milling about the grounds. The view of the mountain - Kit Carson, I believe! - from the living room window is magnificent. The owner was very helpful on the phone, as was the information provided in the home. The Crestone area was beautiful, with so many different things to do - hiking, visiting the Sand Dunes, stopping in the little town (limited choices of restaurants, but we enjoyed the Bliss Cafe, and just cooking at the casita!), and visiting the abundant spiritual sites dotted around the area. I'd be content just sitting on the back porch of this home, however, and doing nothing at all :)"Guest: Lorna Date of Stay: November 2014 Review Submitted: November 10, 2014View listing
"My wife and son and I spent a week in Crestone as a getaway and this was the perfect place for us. Two bedrooms, a well stocked kitchen, BBQ grill, small wood burning fireplace (though the heat works outstanding), linens, and a good location. The house is great and the views are amazing. We had "visitors" ranging from deer to elk to a bobcat while we were there. The locals are all friendly and there is a good little grocery store there. For the money, we couldn't have crammed ourselves in a HI Express for that for the week. (though there isn't one there) Steve and Mia were great to work with. They gave lots of great info, recommendations, and directions to the house and left us contact numbers in case we had any issues. We spent the week hiking, going to the sand dunes, and generally unplugging and taking easy. I highly recommend this house and Steve and Mia."Guest: Chad C. Date of Stay: March 2015 Review Submitted: March 23, 2015View listing
"The house is very nice and well kept, and Michelle was great. My wifeand I felt comfortable there immediately. The steam shower was a great reward after a hike too!"Guest: B E Date of Stay: December 2014 Review Submitted: January 4, 2015View listing
"I took a high school class trip to Crestone for a week and this wonderful house was our home the whole time. It was spacious, elegant, warm, and tasteful, and the tower bedroom is like something out of a fairy tale. The house was built using the sustainable straw-bale method of construction, and it was toasty on the cold November nights. Perhaps the best thing was the price — it's kind of hard to believe how cheap it was to stay here. Why stay in a motel? This is a great rental."Guest: Jeremiah B. Date of Stay: November 2014 Review Submitted: December 3, 2014View listing
Featured Destinations: Breckenridge Lodging, Lake Nacimiento, Smoky Mountain Cabin Rentals, Black Butte Ranch


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Um, your agenda is showing
Dorian Hargrove 5:30 p.m., March 26
Travel. The world's smallest mountain range: the Sutter Buttes, seen on vacation, at the southern side, just outside of Yuba City. The historical marker informs that this is "THE SITE OF PROPAGATION OF THE THOMPSON SEEDLESS GRAPE." Your green table grapes came from here.
Posted October 10, 2012


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Release Date:
July 4, 2008
Date Published:
July 4, 2008
Little Ella Bella loves attending Madame Rosaâ's ballet class at the old theater. Most of all she loves the music that plays from Madame Rosaâ's special music box, the theme from The Sleeping Beauty ballet. One day, after ballet class has ended, Ella Bella is left alone with the music box on the theater stage. As its music begins playing, Ella is transported to the magical world where the Sleeping Beautyâ's story takes place. Entering the palace of Princess Aurora, the Sleeping Beauty, Ella meets all the storyâ's charactersâ?not only the good ones, but also the sinister bad fairyâ?and she sees the famous story unfold before her very eyes. Here is an unusually imaginative retelling of the classic fairy tale, with illustrations that capture the storyâ's magic and mystery. A brief postscript on the bookâ's final page summarizes the history of ballet from its origins during the Italian Renaissance to the late nineteenth-century, when the famous Russian composer Piotr Ilich Tchaikovsky wrote music for The Sleeping Beauty ballet.
- Genre: Juvenile Fiction
- Subgenre: Performing Arts / Dance, Fairy Tales + Folklore / Adaptations
- Publisher: Barrons Juveniles
- Pages: 30
- Language: English
- Author: James Mayhew
other Info.
- Online Item #: 11980324
- Store Item Number (DPCI): 247-03-2393
- Item can be gift wrapped.
- Made in the USA or Imported


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[Due to the increasing size of the archives, each topic page now contains only the prior 365 days of content. Access to older stories is now solely through the Monthly Archive pages or the site search function.]
UT Austin researchers significantly boost yield and speed of lipids production from engineered yeast; more efficient biofuel production
March 24, 2015
Researchers in the Cockrell School of Engineering at The University of Texas at Austin have used a combination of metabolic engineering and directed evolution to develop a new strain of the yeast Yarrowia lipolytica featuring significantly enhanced lipids production that could lead to a more efficient biofuel production process. Their findings were published online in the journal Metabolic Engineering.
Beyond biofuels, the new yeast strain could be used in biochemical production to produce oleochemicals, chemicals traditionally derived from plant and animal fats and petroleum, which are used to make a variety of household products.
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A*STAR team combines fungal culture and acid hydrolyses for cost-effective production of fermentable sugars from palm oil waste
March 16, 2015
Researchers from A*STAR in Singapore have developed a fungal culture for use in a cheap and efficient method to transform waste oil palm material into biofuels and environmentally friendly plastics.
After the harvest of the fruit from oil palm trees, large amounts of leftover biomass known as empty fruit bunch remain. The industry wants to use these leftover fruit bunches to produce bioethanol and biodegradable plastic, but has stumbled in their efforts to convert the leftovers in a cost-efficient way. The new fungal culture could make it possible to produce fermentable sugars from this huge amount of waste in a cost-effective way, thereby increasing its commercial value, said one of the lead researchers, Jin Chuan Wu, from the A*STAR Institute of Chemical and Engineering Sciences.
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New engineered metabolic pathways in yeast enable efficient fermentation of xylose from biomass
March 05, 2015
Researchers with the Energy Biosciences Institute (EBI), a partnership that includes Berkeley Lab and the University of California (UC) Berkeley, have introduced new metabolic pathways from the fungus Neurospora crassa into the yeast Saccharomyces cerevisiae to increase the fermentative production of fuels and other chemicals from biomass. An open access paper on the work is publised in the journal eLife.
While S. cerevisiae is the industry mainstay for fermenting sugar from cornstarch and sugarcane into ethanol, it requires substantial engineering to ferment sugars derived from plant cell walls such as cellobiose and xylose. The new metabolic pathways enable the yeast to ferment sugars from both cellulose (glucose) and hemicellulose (xylose)—the two major families of sugar found in the plant cell wall—efficiently, without the need of environmentally harsh pre-treatments or expensive enzyme cocktails.
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Researchers identify peptide to bind LMNO to improve power and performance of cathodes in Li-ion batteries
February 12, 2015
Researchers at the University of Maryland, Baltimore County (UMBC) have isolated a peptide, a type of biological molecule, which binds strongly to lithium manganese nickel oxide (LMNO), a material that can be used to make the cathode in high-performance Li-ion batteries. The peptide can latch onto nanosized particles of LMNO and connect them to conductive components of a battery electrode, improving the potential power and stability of the electrode.
The researchers presented their results at the 59th annual meeting of the Biophysical Society, held 7-11 Feb.in Baltimore, Maryland.
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Engineered yeast produces ethanol from three important cellulosic biomass components simultaneously; higher yields, lower cost
February 11, 2015
A team led by researchers from the University of Illinois at Urbana−Champaign has, for the first time, integrated the fermentation pathways of both hexose and pentose sugars from biomass as well as an acetic acid reduction pathway into one strain of the yeast Saccharomyces cerevisiae using synthetic biology and metabolic engineering approaches.
The engineered strain co-utilized cellobiose, xylose, and acetic acid to produce ethanol with a substantially higher yield and productivity than the control strains. The results showed the unique synergistic effects of pathway coexpression, the team reported in a paper in the journal ACS Synthetic Biology.
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Researchers use DNA to stabilize sulfur cathode for high-performance Li-sulfur batteries
February 10, 2015
|DNA has a high concentration of heteroatoms, including oxygen, nitrogen and phosphorus, that can anchor soluble polysulfides to improve the cycling performance of Li/S batteries. Li et al. Click to enlarge.
A team from the China University of Geosciences has taken a novel approach to stabilizing Lithium-sulfur batteries by functionalizing the carbon-sulfur cathode with DNA.
Experimental results reported in a paper accepted for publication in the RSC Journal of Materials Chemistry A showed that adding a fine adding amount of DNA into a carbon/sulfur composite enables a significant improvement to cyclic performance by anchoring the soluble polysulfides that lead to performance degradation. The DNA-decorated electrode offered a discharge capacity of 771 mAh·g-1 at 0.1 C after 200 cycles (retention 70.7% of the initial)—a three-fold enhancement in capacity retention over 200 cycles.
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Harvard hybrid "bionic leaf" converts solar energy to liquid fuel isopropanol
Scientists from a team spanning Harvard University's Faculty of Arts and Sciences, Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering at Harvard University have developed a scalable, integrated bioelectrochemical system that uses bacteria to convert solar energy into a liquid fuel. Their work integrates water-splitting catalysts comprising earth-abundant components with wild-type and engineered Ralstonia eutropha bacteria to generate biomass and isopropyl alcohol. An open access paper describing their work is published in Proceedings of the National Academy of Sciences (PNAS).
Pamela Silver, the Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology at HMS and an author of the paper, calls the system a bionic leaf, a nod to the solar water-splitting artificial leaf invented by the paper's senior author, Daniel Nocera, the Patterson Rockwood Professor of Energy at Harvard University. (Earlier post.)
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Researchers discover bacteria could be rich source of terpenes
December 24, 2014
Researchers at Kitasato University in Japan, Brown University in the US, and colleagues in Japan have found that bacteria could be a rich source of terpenes—natural compounds common in plants and fungi that can be used to make drugs, food additives, perfumes, and other products, including advanced fuels (earlier post, earlier post).
Terpenes are responsible for the essential oils of plants and the resins of trees. Since the discovery of terpenes more than 150 years ago, scientists have isolated some 50,000 different terpene compounds derived from plants and fungi. Bacteria and other microorganisms are known to make terpenes too, but they've received much less study. The new research, published in an open access paper in the Proceedings of the National Academy of Sciences, shows that the genetic capacity of bacteria to make terpenes is widespread.
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DOE JBEI team boosts methyl ketone production from E. coli 160-fold; advanced biofuel or blendstock
December 02, 2014
In 2012, researchers at the US Department of Energy's Joint BioEnergy Institute (JBEI) engineered Escherichia coli (E. coli) bacteria to overproduce from glucose saturated and monounsaturated aliphatic methyl ketones in the C11 to C15 (diesel) range from glucose. In subsequent tests, these methyl ketones yielded high cetane numbers, making them promising candidates for the production of advanced biofuels or blendstocks. (Earlier post.)
Now, after further genetic modifications of the bacteria, they have managed to boost the E.coli's methyl ketone production 160-fold. A paper describing this work is published in the journal Metabolic Engineering.
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UCLA researchers develop synthetic biocatalytic pathway for more efficient conversion of methanol to longer-chain fuels
November 18, 2014
Researchers at the UCLA Henry Samueli School of Engineering and Applied Science led by Dr. James Liao have developed a more efficient way to turn methanol into useful chemicals, such as liquid fuels, and that would also reduce carbon dioxide emissions. The UCLA team constructed a synthetic biocatalytic pathway that efficiently converts methanol under room temperature and ambient atmospheric pressures to higher-chain alcohols or other higher carbon compounds without carbon loss or ATP expenditure.
Building off their previous work in creating a new synthetic metabolic pathway for breaking down glucose that could lead to a 50% increase in the production of biofuels (earlier post), the researchers modified the non-oxidative glycolysis pathway to utilize methanol instead of sugar. An open-access paper on the research was published in the 11 Nov. edition of the Proceedings of the National Academy of Sciences.
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JBEI researchers boost isopentenol output from E. coli; potential benefit for bio-gasoline
October 27, 2014
Researchers at the US Department of Energy (DOE)'s Joint BioEnergy Institute (JBEI) have identified microbial genes that can improve both the tolerance and the production of isopentanol in engineered strains of Escherichia coli. Isopentenol is a five-carbon (C5) alcohol that is a highly promising candidate for biogasoline, but, like other short-chained alcohols, is toxic to E.coli at commercial levels of fuel production.
Aindrila Mukhopadhyay, a chemist who directs the host engineering program for JBEI's Fuels Synthesis Division, led a study in which transcriptomic data and a synthetic metabolic pathway were used to identify several genes that not only improve tolerance but also production of isopentenol in E.coli. MetR, the methionine biosynthesis regulator, improved the titer for isopentenol production by 55%, while MdlB, the ABC transporter, facilitated a 12% improvement in isopentenol production.
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Solazyme and Amyris receive Presidential Green Chemistry Challenge awards
October 16, 2014
The US Environmental Protection Agency (EPA) has announced the 5 winners of the 2014 Presidential Green Chemistry Challenge Awards, including biotechnology companies Amyris and Solazyme, Inc. Solazyme received the award for Greener Synthetic Pathways for its tailored oils produced from microalgal fermentation. Amyris received the Small Business award for its renewable hydrocarbon farnesane for use as diesel and jet fuel.
Amyris has engineered yeast to make the hydrocarbon farnesene via fermentation instead of ethanol. Farnesene is a building block hydrocarbon that can be converted into a renewable, drop-in replacement for petroleum diesel without certain drawbacks of first-generation biofuels. A recent lifecycle analysis estimated an 82% reduction in GHG emissions for farnesane, compared with the EPA baseline fossil diesel—including indirect effects.
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BNL team devises new method to boost oil accumulation in plant leaves; implications for biofuel production
October 08, 2014
Researchers at DOE's Brookhaven National Laboratory (BNL) have developed a new method to increase significantly the amount of oil accumulated in plant leaves, which could then serve as a source for biofuel production. Rather than adding genes, as some other research teams have done in their efforts to boost oil accumulation, the BNL method is based on is based on disabling or inactivating genes through simple mutations.
A series of detailed genetic studies revealed previously unknown biochemical details about plant metabolic pathways, including new ways to increase the accumulation of oil in leaves. Using these methods, the scientists grew experimental Arabidopsis plants (widely used as model organisms in plant biology), the leaves of which accumulated 9 wt % oil. This represented an approximately 150-fold increase in oil content compared to wild type leaves. A paper on their work is published in the journal The Plant Cell.
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Researchers enhance yeast thermotolerance and ethanol tolerance; potential for significant impact on industrial biofuel production
October 03, 2014
The yeast Saccharomyces cerevisiae plays a central role in global biofuel production; currently, about 100 billion liters of ethanol are produced annually worldwide by fermentation of mainly sugarcane saccharose and corn starch by the yeast. There are also efforts underway to use the yeast with cellulosic biomass.
Boosting the yield and lowering the cost of fermentative production of biofuel would not only result in a significant immediate financial impact to commercial ethanol operations, but also support cost reductions that would be helpful to advance other advanced biofuels using the same or a similar pathway. However, boosting production has been gated by two key conditions: the ability of the yeast to tolerate higher temperatures, and the ability of the yeast to survive high concentrations of ethanol. Now, two new separate studies report progress on each of those fronts; the findings could have a significant impact on industrial biofuel production. Both papers are published in the current issue of the journal Science.
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ARPA-E to award $60M to 2 programs: enhancing biomass yield and dry-cooling for thermoelectric power
October 02, 2014
|ARPA-E's vision of advanced phenotyping to enhance biomass yield. Click to enlarge.
The US Department of Energy's Advanced Research Projects Agency-Energy (ARPA-E) will award up to $60 million to two new programs ($30 million each). The Transportation Energy Resources from Renewable Agriculture (TERRA) program (DE-FOA-0001211) seeks to accelerate biomass yield gains (especially energy sorghum) through automated, predictive and systems-level approaches to biofuel crop breeding. The Advanced Research In Dry cooling (ARID) program (DE-FOA-0001197) aims to develop low-cost, highly efficient and scalable dry-cooling technologies for thermoelectric power plants.
TERRA. ARPA-E posited that there is an urgent need to accelerate energy crop development for the production of renewable transportation fuels from biomass. While recent advances in technology has enabled the extraction of massive volumes of genetic, physiological, and environmental data from certain crops, the data still cannot be processed into the knowledge needed to predict crop performance in the field. This knowledge is required to improve the breeding development pipeline for energy crops.
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German researchers boost algal hydrogen production five-fold using metabolic engineering approach
September 25, 2014
Scientists from the Max Planck Institutes for Chemical Energy Conversion and Coal Research and from the research group Photobiotechnology at Ruhr-Universität Bochum (RUB) have discovered a way of increasing the efficiency of hydrogen production in microalgae by a factor of five by using a combined metabolic engineering approach. An open access paper on their work is published in the RSC journal Energy & Environmental Science.
The genetic modifications resulting in the enhanced light-driven hydrogen production opens new avenues for the design of H2-producing organisms, which might lead to the design of an economically competitive hydrogen producing organism, the researchers suggest.
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Researchers successfully engineer E. coli to produce renewable propane; proof-of-concept
September 03, 2014
Researchers from the University of Turku in Finland, Imperial College London and University College London have devised a synthetic metabolic pathway for producing renewable propane from engineered E. coli bacteria. Propane, which has an existing global market for applications including engine fuels and heating, is currently produced as a by-product during natural gas processing and petroleum refining. A paper on their work is published in Nature Communications.
The new pathway is based on a thioesterase specific for butyryl-acyl carrier protein (ACP), which allows native fatty acid biosynthesis of the Escherichia coli host to be redirected towards a synthetic alkane pathway. Although the initial yields were low, the team was able to identify and to add essential biochemical components in order to boost the biosynthesis reaction, enabling a the E. coli strain to increase propane yield, although the amounts are still far too low for commercialization.
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DOE, USDA awarding $12.6M to 10 biomass genomics research projects for improved biofuels
July 17, 2014
The US Department of Energy (DOE) and the US Department of Agriculture (USDA) have selected 10 projects that will receive funding aimed at accelerating genetic breeding programs to improve plant feedstocks for the production of biofuels, biopower, and bio-based products.
The $12.6 million in research grants are awarded under a joint DOE-USDA program that began in 2006 focused on fundamental investigations of biomass genomics, with the aim of harnessing nonfood plant biomass for the production of fuels such as ethanol or renewable chemical feedstocks. Dedicated feedstock crops tend to require less intensive production practices and can grow on poorer quality land than food crops, making this a critical element in a strategy of sustainable biofuels production that avoids competition with crops grown for food.
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Calysta reports 8-fold improvement in gas fermentation in ARPA-E program; BioGTL
July 10, 2014
Calysta, Inc. reported that it has achieved 8-fold improved performance over traditional fermentation technologies in a high mass transfer bioreactor. The bioreactor technology is under development for efficient methane-to-liquids fermentation processes, enabling rapid, cost-effective methane conversion into protein, industrial chemicals and fuels. (Earlier post.)
The improved performance was achieved in the research phase of a program funded in part by the Department of Energy's ARPA-E program under the REMOTE program (Reducing Emissions using Methanotrophic Organisms for Transportation Energy), awarded in September 2013. (Earlier post.) Calysta develops sustainable industrial products using novel natural gas conversion technology using methane.
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Joule first to gain US EPA clearance for commercial use of modified cyanobacteria for fuel production
July 01, 2014
The US Environmental Protection Agency (EPA) has favorably reviewed Joule's Microbial Commercial Activity Notice (MCAN) for the company's first commercial ethanol-producing catalyst (a modified Synechococcus cyanobacterium). This clears the catalyst for commercial use at the company's demonstration plant in Hobbs, New Mexico.
This also marks the first time that EPA has allowed the commercial use of a modified cyanobacterium (although not of other modified microorganisms such as S. cerevisiae, E. coli, T. reesei, etc.). (The full list of EPA notifications under the Toxic Substances Control Act—TSCA—is available here.)
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International team sequences Eucalyptus genome; potential for improving biofuel and biomaterial production
June 14, 2014
An international team of researchers has sequenced the genome of the eucalyptus tree (Eucalyptus grandis) and published the analysis in an open access paper in the journal Nature. With its prodigious growth habit, the eucalyptus tree, one of the world's most widely planted hardwood trees, has the potential to enhance sustainable biofuels and biomaterials production, and to provide a stable year-round source of biomass that doesn't compete with food crops.
The researchers reported the sequencing and assembly of more than 94% of the 640-megabase genome of Eucalyptus grandis. Of 36,376 predicted protein-coding genes, 34% occur in tandem duplications, the largest proportion thus far in plant genomes. Eucalyptus also shows the highest diversity of genes for specialized metabolites such as terpenes, which can be substituted catalytically for jet fuel.
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Lux Research: cost of electrofuels remains far from viable
June 09, 2014
|Production costs per barrel of oil equivalent. Source: Lux Research. Click to enlarge.
The cost of electrofuels—fuels produced by catalyst-based systems for light capture, water electrolysis, and catalytic conversion of carbon dioxide and hydrogen to liquid fuels—remains far away from viable, according to a new analysis by Lux Research.
Building a cost model for the electrolysis process—considering electricity from various routes, such as natural gas and coal as well as renewable electricity from biomass, solar, and wind, as well as generously assuming commercial scale production—Lux found that electrofuels produced from microbes cost $230 per barrel, while a catalytic conversion to make electrofuels produces fuels for $208 per barrel.
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UGA-led team engineers bacterium for the direct conversion of unpretreated biomass to ethanol
June 03, 2014
A team led by Dr. Janet Westpheling at the University of Georgia has engineered the thermophilic, anaerobic, cellulolytic bacterium Caldicellulosiruptor bescii, which in the wild efficiently uses un-pretreated biomass—to produce ethanol from biomass without pre-treatment of the feedstock. A paper on the work is published in Proceedings of the National Academy of Sciences (PNAS).
In January, Dr. Westpheling and her colleagues reported in the journal Science their discovery that an enzyme (the cellulase CelA) from C. besciia can digest cellulose almost twice as fast as Cel7A, the current leading component cellulase enzyme on the market. (Earlier post.)
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MSU microbial electrolysis cell produces ethanol from glycerol, reduces wastewater in biodiesel production
May 22, 2014
|The MEC uses syntrophic cooperation within a bacterial consortium (red and green) in the anode chamber to ferment ethanol from glycerol and to remove inhibiting H2. Credit: ACS, Speers et al. Click to enlarge.
Researchers at Michigan State University have developed a microbial electrolysis cell (MEC) which will allow biodiesel plants to eliminate the creation of hazardous wastes while reducing their dependence on fossil fuel.
The platform, which uses microbes to produce ethanol from glycerol, has the added benefit of cleaning up the wastewater, will allow producers to reincorporate the ethanol and the water into the fuel-making process, said Gemma Reguera, MSU microbiologist and one of the co-authors. The ethanol replaces petrochemical methanol in the biodiesel production. A paper on their work is published in the ACS journal Environmental Science & Technology.
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Researchers engineer poplar trees for easier degradation of lignin to ease production of biofuels
April 04, 2014
|Poplar vascular tissue showing feruloyl-coenzyme A (CoA) monolignol transferase (FMT) expression. Source: GLBRC. Click to enlarge.
Researchers from Michigan State University and the University of Wisconsin-Madison and their colleagues report successfully engineering poplar trees to produce lignin that degrades more easily, thereby lowering the effort and cost to convert wood to biofuel. A paper on their work appears in the journal Science.
Poplar trees are a fast-growing wood crop widely planted throughout the United States and Canada, and are particularly valuable to the bioenergy, bio-products, and fiber industries. Lignin provides strength to wood but also impedes efficient degradation when wood is used as feedstock for biofuel. The researchers identified an enzyme (coniferyl ferulate feruloyl-CoA monolignol transferase) in other plants that contain more digestible lignin monomers, then expressed it in poplar. The resulting trees showed no difference in growth habit under greenhouse conditions, but their lignin showed improved digestibility.
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Synthetic biology company launches JV to commercialize gas-to-liquids bioconversion; isobutanol first target
March 28, 2014
Synthetic biology company Intrexon Corporation has formed Intrexon Energy Partners (IEP), a joint venture with a group of external investors, to optimize and to scale-up Intrexon's gas-to-liquids (GTL) bioconversion platform. IEP's first target product is isobutanol for gasoline blending.
Intrexon's natural gas upgrading program is targeting the development of an engineered microbial cell line for industrial-scale bioconversion of natural gas to chemicals, lubricants and fuels, as opposed to employing standard chemical routes. Intrexon says it has already achieved initial proof of concept with an engineered microbial host converting methane into isobutanol in a laboratory-scale bioreactor.
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Scientists synthesize first functional designer chromosome in yeast
An international team of scientists led by Dr. Jef Boeke, director of NYU Langone Medical Center's Institute for Systems Genetics, has synthesized the first functional chromosome in yeast, an important step in the emerging field of synthetic biology—designing microorganisms to produce novel medicines, raw materials for food, and biofuels. A paper on the accomplishment is published in the journal Science.
Over the last five years, scientists have built bacterial chromosomes and viral DNA, but this is the first report of an entire eukaryotic chromosome built from scratch. Researchers say their team's global effort also marks one of the most significant advances in yeast genetics since 1996, when scientists initially mapped out yeast's entire DNA code, or genetic blueprint.
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Lawrence Livermore, JBEI researchers engineer bacteria with tolerance to ionic liquids for enhanced production of advanced biofuels
March 26, 2014
Researchers from Lawrence Livermore National Laboratory in conjunction with the Joint BioEnergy Institute (JBEI) have engineered tolerance to ionic liquids (ILs)—used for biomass pretreatment, but generally toxic to bacteria—into biofuel-producing bacteria.
The results, reported in an open access paper in Nature Communications are likely to eliminate a bottleneck in JBEI's biofuels production strategy, which relies on ionic liquid pretreatment of cellulosic biomass. The research also demonstrates how the adverse effects of ionic liquids can be turned into an advantage, by inhibiting the growth of other bacteria.


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Date Created: 7/17/2006
Date Modified: 11/13/2014
ALERT! This benefit covers only services that meet the criteria below. If you receive services during a preventive care visit that do not meet these requirements, they will not be covered as preventive care. Instead, when medically necessary, the services are subject to the medical deductible and are covered under the specific benefit the charges apply to (such as diagnostic tests, laboratory, or X-rays). If your provider bills for your visit as medical treatment instead of an annual physical exam or other preventive service, it may be covered under the medical benefit and subject to the deductible and coinsurance.
You don't have to meet your deductible* before the plan pays for services covered under the preventive care benefit. When you see a preferred provider for these services, you pay nothing. If you see an out-of-network provider, you pay 40% of the allowed amount and the provider may balance bill you. However, if you do not have access to a preferred provider for preventive services, the plan may pay at 100% of billed charges. See how to request a network waiver.
Note: Recommendations added during the calendar year may not be covered as preventive until later years.
TIP: You don't usually need to wait until a specific date between preventive care exams. For example, you could have a preventive exam near the end of one year, and again at the beginning of the next year; however, you would not qualify for another preventive exam until the following year. Some screening tests are limited; call 1-888-849-3681 with questions.
Examples of services covered under the preventive care benefit include:
You may call Customer Service at 1-888-849-3681 to ask if a service is covered as preventive.
For additional services covered as preventive for women, see "Coverage of family planning services," "Coverage of mammograms," and "Coverage of obstetric and newborn care."
*For UMP Classic, this is the medical deductible.
ALERT! Follow-up visits or tests are not covered under the preventive care benefit. If the test or visit is normally covered by the plan and is medically necessary, the plan pays under the medical benefit.
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I confess, I pack with near-military precision, fitting everything into a rolling carry-on bag even for a month-long trip. During my most recent trip — a month in Italy inspecting properties — I moved accommodations every couple of nights because staying in our properties is the best way to inspect.
Rome's Stately Piazza del Popolo
Piazza del Popolo was, and is, a truly impressive welcome to Rome, beautifully proportioned, it is anchored by an Egyptian obelisk (acquired from Egypt by Augustus Caesar during his conquests) which theme is carried forward with a fountain featuring Egyptian lions and a dozen sphinxes on the surrounding wall. The arched portal to Piazza del Popolo was designed by Bernini for Pope Alexander VII. The most unassuming church in the Piazza, Santa Maria del Popolo, has beautiful treasures of the Renaissance: a dramatic tomb mentioned as the scene of a crime in Dan Brown's DaVinci Code, and two magnificent paintings by Caravaggio. The other two churches on the piazza are called "twins" and, at first glance look alike; it is fun to stop and identify the many differences in their architecture. Continue reading
Italy Perfect Featured in Travel + Leisure Magazine
Irresistibly Creative Italian Idiomatic Expressions
We love the rich stories these comic and creative idiomatic expressions tell. We can only hope that the English language can evolve to emulate these charming and picturesque expressions. They begged our little cartoons.
Ha le braccine corte. — He has little short arms.
His arms are so short he can't reach his wallet. He is cheap!
Take your Children to Florence
Italy is one of the most child friendly countries in the world. Your precious 'bambina' will have her cheeks pinched and your 'bambino' will be whisked off to the kitchen to taste some fresh schiacciata. If you're travelling with a baby, be ready to get more attention than you've ever experienced — from grandmothers and waiters and young couples all. Continue reading


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This Inn is in a great location in the historic Victorian district. The wine and cheese and deserts/coffee in the evening was a nice touch and the full breakfast in the courtyard patio in the mornings was fantastic! The bed was a little high but had a stairstep to get into it. I stayed in one of the courtyard rooms in back,not the main house which I think I would prefer. There are some stairs to manage so that could be an issue if you need special accomendations.
- Official Description (provided by the hotel):
- The Eliza Thompson House is an exquisite 1847 bed and breakfast inn located on beautiful Jones Street. Recommended by Conde Nast Johansens and known for superior service, this inn is private, peaceful, and just a short walk from Savannah's most-loved historic attractions. ... more less
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- TripAdvisor is proud to partner with Travelocity, Expedia, Booking.com, Hotels.com, Odigeo and Tingo so you can book your Eliza Thompson House reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
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Are you Adina Roceanu?Claim your profile
Publications (10)11.57 Total impact
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ABSTRACT: Chronic migraine (CM) is defined as headache occurring more than fifteen days/month for at least three consecutive months, with headache having the clinical features of migraine without aura for at least eight days per month. Recently, new treatment options became available in chronic migraine patients. Topiramate is effective in chronic migraine, in the presence or absence of medication overuse, and/or other migraine prophylaxis. Efficacy of onabotulinumtoxin A as a preventive treatment of chronic migraine has been shown in the PREEMPT studies. Occipital nerve stimulation (ONS) is an invasive treatment for refractory chronic headaches. ONS has encouraging results in refractory chronic migraine patients in commercially funded, multi-centre randomized trials.
Article: Microemboli detection in patients with carotid artery stenting - A potential marker for future cognitive impairment?[Show abstract] [Hide abstract]
ABSTRACT: To monitor the long-term cognitive function evolution of patients undergoing carotid artery stenting (CAS), using detection of embolic signals (ES) as a potential marker of cognitive decline. This is an ongoing prospective nonrandomized single-center study of patients undergoing carotid artery angioplasty and stenting using standard techniques. Neurologic status is evaluated by history, physical examination and the National Institutes of Health Stroke Scale. A complete Doppler-ultrasound investigation of the brain-supplying arteries has been performed in every patient. A 45minute cognitive battery designed to assess motor speed/coordination and executive function, psychomotor speed, language (naming), working memory/concentration, verbal fluency, and learning/memory is performed by a certified neuropsychologist in the first week after CAS and repeated a year after the procedure. Each patient undergoes bilateral ultrasonographic-Doppler monitoring of the middle cerebral artery (MCA) for microemboli detection. The patients are monitored during the first week after CAS and again a year after stenting. 32 patients were included. The mean baseline Mini-Mental State Examination (MMSE) score was 28.7 points. During the first ultrasonographic monitoring 28 patients (87.5%) had at least three times more ES detected on the stented side (a mean of 24ES/30minutes was detected in the stented side compared to a mean of 4ES/30min in the non-stented side). At the one-year follow-up 68% of the patients who have undergone CAS maintain a high number of ES detected in the territory of the stented carotid artery, finding that is well correlated with the cognitive decline in those patients, as assessed by the MMSE score. ES detection is a useful tool for predicting cognitive decline that can be used to monitor CAS patients and adjust preventive measures in order to avoid progression of vascular cognitive impairment. It is important that further studies comparing carotid endarterectomy and CAS monitor long-term cognitive function outcome.Journal of the neurological sciences 03/2013; 326(1-2):96-9. DOI:10.1016/j.jns.2013.01.025 · 2.32 Impact Factor
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ABSTRACT: Some patients with ischemic stroke are subject to hemorrhagic transformation, a complication leading to increased patient morbidity and mortality. The discovery of biomarkers that can be used to identify ischemic strokes prone to this complication are very important for the clinical practice because therapy could be altered to mitigate the risk. We discuss here the results of a trial that evaluated for the first time tight junction proteins as biomarkers of blood-brain barrier disruption and hemorrhagic transformation in ischemic stroke.12/2012; 7(4):355-357.
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ABSTRACT: The actual criteria for diagnosis of dementia have many shortages, due to the fact that both DSM 4 and ICD 10 criteria are essentially based on the typical evolution of Alzheimer's disease, which is the most frequent, but not the only one cause of dementia in the general population. In the new project of DSM-5, proposed for public debate by the American Psychiatric Association (APA), new criteria for neurocognitive disorders are defined which seem more suitable to cover in a much more appropriate way all the entities potentially leading to dementia. In our view, these new criteria are also in line with the updated knowledge about these diseases as they are reflected in the recent publications and recommendations of international experts and medical associations.Journal of the neurological sciences 08/2012; 322(1-2):17-9. DOI:10.1016/j.jns.2012.07.067 · 2.32 Impact Factor
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ABSTRACT: Magnetic resonance imaging (MRI) has been explored as a noninvasive tool to assess pathology in multiple sclerosis (MS) patients. However, the correlation between classical MRI measures and physical disability is modest in MS. The diffusion tensor imaging (DTI) MRI technique holds particular promise in this regard. The present study shows brain regions where FA and individual diffusivities abnormalities are present and check their correlations with physical disability clinical scores. Eight patients and 12 matched healthy controls were recruited. The Multiple Sclerosis Functional Composite was administered. For MR-DTI acquisitions, a Genesis Signa 1.5 T MR system, an EP/SE scanning sequence, 25 gradient directions were used. Tract Based Spatial Statistics (TBSS) group comparisons showed reduced FA and increased individual diffusivities in several brain regions in patients. Significant correlations were found between FA and: EDSS, 9-HPT(NON)DOM and 25 FW score; between λ2 and: P100 (r&l), 9-HPT(NON)DOM and 25 FW; between λ3 and: 9-HPT(NON)DOM and 25 FW score. Fractional anisotropy and individual radial diffusivities proved to be important markers of motor disabilities in MS patients when the disease duration mean and the disability scores values range are relatively high.European journal of radiology 03/2012; 81(3):e386-91. DOI:10.1016/j.ejrad.2011.12.014 · 2.65 Impact Factor
Romanian Journal of Legal Medicine 01/2012; 20(3):207-210. DOI:10.4323/rjlm.2012.207 · 0.15 Impact Factor
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ABSTRACT: Optic neuropathy (ON) is defined as the reduction of vision due to inflammatory lesion of the optic nerve. The patient with ON has to be evaluated clinically but also with complex techniques (magnetic resonance imaging, visual evoked potentials, cerebrospinal fluid examination) because ON could be the presenting symptom in multiple sclerosis patients. Corticosteroids should be administrated intravenous and the patient should be followed by the neurologist in order to signal the appearance of new neurological signs.Oftalmologia (Bucharest, Romania: 1990) 01/2010; 54(1):3-8.
Article: Abnormalities of the vestibulo-collic reflex are similar in migraineurs with and without vertigo.[Show abstract] [Hide abstract]
ABSTRACT: The amplitude and habituation of the click-evoked vestibulo-collic reflex (VCR) was found reduced between attacks in migraineurs without complaints of ictal or interictal vertigo or dizziness, compared with healthy subjects. As a next step we recorded VCR in 17 migraine patients (eight with migraine without aura and nine with migraine with aura) who presented ictal migrainous vertigo according to the criteria defined by Neuhauser et al., using a method described previously. Migraineurs with migrainous vertigo have similar VCR abnormalities as patients without vertigo, i.e. a decreased global amplitude and absence of habituation. Potentiation seemed more pronounced in migraineurs with vertigo (7.46 +/- 18.6), but the difference was not significant.Cephalalgia 08/2008; 28(9):988-90. DOI:10.1111/j.1468-2982.2008.01641.x · 4.12 Impact Factor
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ABSTRACT: Vertigo and dizziness are frequently reported by patients with migraine. There is a high co-morbidity between migraine and balance disturbance, but clinical observations suggest that vertigo can be an independent migrainous symptom. Vertigo and dizziness can be related to migraine in various ways: causally (migrainous vertigo), statistically (vertigo syndrome are not caused by migraine, but show a statistical association, possibly as a result of on association of both condition with a third factor) or just by chance (co-existence by coincidence). The recent term of migrainous vertigo (MV) is more precise in defining migraine and balance symptoms occur as a part of a single phenomenon, differentiating from simply co-morbid symptoms. Because MV is not presently included in the IHS classification of migraine, Neuhauser et al. proposed operational clinical criteria modelled on IHS headaches classification.
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ABSTRACT: Reproductive endocrine dysfunction has been reported during adolescence and adulthood in female subjects with epilepsy. Epilepsy itself and antiepileptic drugs (AEDs) may have complex interactions with reproductive system. Reproductive endocrine disorders may have an impact on fertility in women with epilepsy, and therefore it is important to identify the possibly treatable disorders. We report a young epileptic woman, with idiopathic primary generalized seizures, treated with lamotrigine in the last 12 months, without seizures, who presented endocrine-reproductive dysfunction (irregular menstrual cycles, elevated estradiol levels and LH/ FSH ratio, and polycystic ovaries).
Top Journals
Spitalul Universitar de Urgenta BucurestiBucureşti, Hunedoara, Romania
Spitalul Universitar de Urgenţă BucureştiBucureşti, Bucureşti, Romania
University of Liège
Luik, Walloon Region, Belgium
- Department of Neurology


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text: Meta Battle Subway PokeBase - Pokemon Q&A Login Register All Activity Questions Unanswered Tags Users Ask a Question Rules Chat Recent questions tagged xd 0 votes 1 answer 169 views What Pokemon are XD and Colosseum exclusive? asked Feb 7, 2014 by Killla colosseum xd 0 votes 1 answer 288 views Can you purify shadow Lugia before beating the game? asked Jan 9, 2014 by ThePunslinger xd lugia gen-3 0 votes 1 answer 221 views How many Ludicolo does Miror B. own? asked Mar 15, 2013 by Soundwave xd 0 votes 1 answer 272 views Where can I find an EXP. Share in Pokemon XD: Gale of Darkness? asked Nov 27, 2012 by Wolfspell31 exp-share xd 0 votes 1 answer 461 views Which Pokemon in Colosseum and XD can learn the moves listed below? asked Oct 29, 2012 by trachy xd colosseum moves 0 votes 1 answer 7,297 views What are all the moves Pokemon get when fully purified in Colosseum and XD? asked Oct 29, 2012 by trachy colosseum xd purified moves 0 votes 2 answers 1,828 views What are all the TMs/HMs available in Colosseum and XD? And which ones are available for purchase? asked Oct 29, 2012 by trachy colosseum xd tms hms 0 votes 1 answer 2,695 views Can you find Shiny Pokemon in Colosseum and Pokemon XD:Gale of Darkness? asked Sep 9, 2012 by Aura Warrior xd colosseum shiny 0 votes 1 answer 1,269 views Aerodactyl with rock head asked May 3, 2012 by MiniNinetales rock-head aerodactyl brave-bird xd colosseum head-smash 0 votes 1 answer 350 views Pokemon XD Gale of Darkness & Colosseum question. asked Apr 19, 2012 by Latios xd colosseum 0 votes 1 answer 351 views Does Pickup work in Pokemon XD? asked Aug 23, 2011 by Latios xd pickup 1 vote 1 answer 226 views I have four Dark types on my Pokemon XD gale of darkness,which should I keep? asked Jul 20, 2011 by Felipe123 xd team 1 vote 1 answer 1,005 views Why do Smeargles in Pokemon XD all have the shiny sprite? asked Jul 15, 2011 by pullerrush shiny xd smeargle 0 votes 1 answer 1,299 views Is it possible to trade between Pokemon XD and Pokemon Leafgreen? asked Jul 3, 2011 by pullerrush xd trading leafgreen 2 votes 1 answer 355 views is there any easy way to complete the orre colosseum? asked Jun 30, 2011 by Latios xd lucky-egg orre colosseum 1 vote 1 answer 535 views if you trade a shiny pokemon to the xd gale of darkness game it will still being shiny? asked Jun 30, 2011 by Latios shiny colosseum xd 0 votes 2 answers 180 views Where can I find a walkthrough for Pokemon XD Gale of Darkness? asked Jun 27, 2011 by pullerrush xd walkthrough 0 votes 2 answers 401 views Is a shadow move 4x effective or 2x effective? asked Jan 5, 2011 by Xapper super-effective shadow-move shadow colosseum xd 1 vote 2 answers 338 views What happens if a shadow move hit a shadow pokemon? asked Jan 5, 2011 by Xapper shadow colosseum xd shadow-move shadow-pokemon To see more, click for the full list of questions or popular tags. Useful Meta Posts How to change your username How to add a user avatar Why was my post hidden? The points system Question etiquette Flags vs Downvotes Anime FAQ


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MUMBAI (Reuters) - Private equity funds quadrupled their investment in India's primary healthcare, betting the sick and ailing will stop seeing family doctors in often cramped and dingy quarters and check into modern chains sprouting up across Asia's No.3 economy.
Goldman Sachs Group Inc, Warburg Pincus LLC, Sequoia Capital and the Government of Singapore Investment Corp are among investors that pumped $520 million into India's basic healthcare industry this year, compared with $137 million in 2011, according to Thomson Reuters data. Some analysts predict investment will surpass $1 billion in 2013.
Organised healthcare providers including Apollo Hospitals Enterprise Ltd and Fortis Healthcare Ltd are betting that growing numbers of patients will be willing to pay two or three times more for better-equipped clinics - all under a model that can be replicated fast and offers investors the potential for quick returns.
"The family doctor concept is slowly phasing out as migrants in cities look out for a brand rather than visiting a general physician next door," said Santanu Chattopadhyay, CEO of NationWide Primary Healthcare Services, in which U.S.-based Norwest Venture Partners has invested $4.6 million.
The opportunity is vast: India's unorganised primary healthcare system is worth $30 billion and is growing at least 25 percent a year. The challenge will be convincing the sick to give up their trusted family doctors.
The country's primary healthcare sector will draw at least $1 billion annually in private equity investment over the next couple of years, said Shantanu Deb Mookerjea, executive director at Mumbai-based advisory firm LSI Financial Services.
"Single-speciality chains and diagnostic laboratories will be the game changer," he said, adding that they are easy to set up and expand to suit demand.
Another attraction is that primary healthcare providers such as outpatient clinics and diagnostic centres are not capital-intensive, so investors don't have to write out big cheques.
Also, unlike many restrictive Indian industries, from insurance to real estate and telecoms, there are no limits on foreign ownership in healthcare.
GRAPHIC: Investments in India's primary healthcare, click link.reuters.com/zuc74t
GRAPHIC-Capital costs of Indian hospitals, click link.reuters.com/byc74t
Healthcare, like restaurant chains, is a play on rising spending power in India, although valuations tend to be lower than the retail sector. Investors pay single-digit multiples on price-to-earnings in primary healthcare, compared with 15 to 18 for food and other consumer chains.
Valuations could improve if private healthcare operators also adopted a restaurant franchise model.
Under such a model, a healthcare operator would allow a franchisee to use its brand and provide expertise and support in exchange for a fee. The franchisor would avoid forking out money to set up new clinics - investments that will be borne by the franchisee.
"We would prefer to value our company based on our franchisee consumer model like a pizza (chain) rather than as a pill made by a drugmaker," said Atul Bhide, director of finance at Mumbai-based Vaidya Sane Ayurved Laboratories, which operates 160 clinics providing traditional ayurvedic treatment.
As a result, healthcare has been a rare bright spot for private equity in India, where overall investment fell 17 percent this year to about to $3.3 billion.
"From small hospital chains and specialised treatment facilities, we are witnessing increased institutionalised activity, which could attract a lot of institutional investment interest," said Vishakha Mulye, CEO of ICICI Venture, the private equity arm of ICICI Bank Ltd.
Last year, Mulye's fund sold its stake in diagnostic chain Metropolis Healthcare to Warburg Pincus for 3.92 billion rupees, a 10-fold return on its 350-million-rupee investment in 2006.
The biggest challenge will be convincing patients such as Chandrashekhar Khandke, a 30-year-old software professional at IBM in Pune, who said he has visited modern clinics a few times but still prefers his family doctor.
"If I buy grains from a grocery store or from a supermarket, it doesn't make much of a difference but when it comes to health, a family doctor matters a lot," he said.
Overcoming the draw of a trusted doctor may prove harder than it seems, even in a country where healthcare infrastructure is poor, electronic medical records are rare, and the quality of doctors and other medical professionals is patchy.
"Although branded clinics have potential, they find it tough to pull patients from a strong local doctor. Also, if there is a big hospital in the vicinity, then they lose out on patients," said Deepak Malik, analyst at Mumbai-based brokerage Emkay Global Financial Services Ltd.
While fees at modern clinics range from 150 to 600 rupees for treatment of routine illness, sole general practitioners charge patients anything between 50 and 300 rupees per visit.
"While these chains have a unique brand, a trusted doctor is even a bigger brand," said Anil Advani, a doctor who operates an old but modest 800-square-foot (75-square-metre) clinic in Thane, outside Mumbai.
(Editing by Tony Munroe and Ryan Woo)
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Zoysia Plugs in a bermuda lawn
moegertyMarch 30, 2013
So which one wins? I am interested in switching to Zoysia, but do not want to go through the whole process of removing and starting over
Is plugging a viable option? Or am I just being hopeful?
Also, which is the best type of Zoysia for north Dallas?
dchall_san_antonio(8 San Antonio)
Correct, bermuda wins. I tried that. Bemuda definitely wins. While the zoysia I used is fairly aggressive, it cannot compete with bermuda in dry conditions. Zoysia is subject to problems that make it go dormant for up to 12 months. When that happens, it is wide open territory for the bermuda to move in.


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Electric bike maker GoGreen BOV plans to set up a manufacturing facility for batteries with a Korean firm near Bangalore.
Announcing this at the launch of a new line of e-bikes here on Wednesday, GoGreen BOV Executive Director A. Dhivik said 60 acres in the neighbouring Kolar district had been acquired and the estimated investment in the joint venture was $10 million.Cost-benefits
With the batteries, at least 80 per cent of the products were to be made in the State, a move expected to deliver cost-benefits. The joint venture was likely to be floated around October, he said, while refusing to divulge the name of the Korean battery manufacturer with whom the facility is to be set up.
Over 50 per cent of the parts are imported now, while the manufacturing unit of GoGreen BOV, also in Kolar, makes various components, including frame, chassis and wiring harness. The investment in the business, co-founded by Mr. Dhivik and his father Ashok Reddy, was $2 million and the company, in four years, sold over 14,000 vehicles. While Karnataka, Tamil Nadu and Kerala were the key markets now, the company wanted to expand to Andhra Pradesh, Maharashtra and a few more States.
On e-bikes, he said as they were classified under the non-motor vehicle category no road tax or registration charges were to be paid. Comprehensive and third party insurance were available. The battery is to be replaced after over two years and the cost is around Rs.7,000.
The four new models, whose costs range from Rs.38,000 to Rs.59,500, were targeted at school students in the 15-18 age group, women, small traders and restaurants.
The feature of the GoGreen BOV bikes was their range — of 60 km to 120 km per charge.
Keywords: Electric bikes, e-bikes, GoGreen BOV, Kolar electric bike manufacturing, Gogreen BOV Korean JV


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This algorithm has been in my mind for a long time, but I cannot find it described anywhere. It's so simple though that I can't be the only one who has thought of it. Here's how it works:
You start with an image. Say, 7x7px:
You need to resample it say, to 5x5px:
So all you do is take the average color of each new square:
This isn't the nearest-neighbor, because that takes the color of just one pixel, not fractional pixels who happen to overlay the source pixel. It's also not bilinear, bicubic, lanczos or anything else interpolating.
So - what is it? It intuitively seems to me that this should be the "mathematically perfect" resampling algorithm, although since I don't have a definition of what "mathematically perfect" is, I cannot prove or disprove that.
Last but not least, "mathematically perfect" isn't always "best looking", so I wonder how it compares to other mainstream image resampling algorithms (bicubic, lanczos) in terms of "quality"? This is a subjective term, of course, so I'm really interested if there are significant differences between this algorithm and others, which most people would agree upon.
P.S. A few things I can already tell about it - it won't be "best looking" for pixel art, as demonstrated here; there are special algorithms for that (2xSAI etc); and also it won't be best for enlarging pictures - interpolation would win out there. But for shrinking pictures...?
Update 1: Hmm, just found out about supersampling. This seems like a variant of it, with a grid-type arrangement of samples, where the number of samples is optimized for the resolution of the source & target images.


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DBAM Installs Soundcraft Si3 In Capellia Cultural Centre
The aim of the Capellia Cultural Centre is to enable the town of La Chapelle-sur-Erdre to work every day to promote artistic and cultural education for all, allowing people of all generations to take, renew and revive their talents in harmony with each other.
To achieve this, the Cultural Centreâs entertainments team creates demanding programmes and spectacles in a number of disciplines â song, dance, circus, choreography, comedy, music and theatre (including for young audiences). more
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Fabulous 1930's Art Deco building in perfect location. Greataccomodation we even got upgraded to a 2 bedroom 2 bathroom apartment.Very private and comfortable. Nice being able to wake up and make acafitiere of coffee before facing the world. - Anonymous
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The staff made sure we had a nice stay. Rooms were comfortable. It is close to knightsbridge - great if you want to shop from harrods and other shops such as prada and zara - Rita
Odd entrance but staff were excellent to us over our stay better than any other place that I have stayed. location was perfect for stay being just off the main roads but still quiet with minimal traffic noise. Would stay here again. - Ian
Loistava sijainti. Kodikas. Baari 24 h auki vieraille, hieno juttu. Ystävällinen henkilökunta. - Seilonen
Great location 5 mins from Earls Court tube and 12 minutes walk from Natural History Museum! Very friendly staff - prepared our room early, gave us some extra pillows, helped our kids with making toasts.
Breakfast was very good too - toasts, butter, jams, 3 kinds of cornflakes, milk, juices, boiled eggs, sliced cheese, tea, coffee.
GREAT value for money! - Anonymous
Sijainti erinomainen ja hinta/laatusuhde hyvä huoneesta. Henkilökunta ystävällistä. - Jouni
Sijainti on aivan mahtava. Henkilökunta on myös erittäin ystävällistä ja palveluhenkistä! - Jyrki-pekka


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MEMPHIS – Monogram Food Solutions LLC announced on Sept. 6 that it had acquired Hinsdale Farms, a corn dog manufacturer based in Bristol, Ind. The deal includes Hinsdale's processing plant, which spans 110,000 sq. ft. and employs 300 workers. Hinsdale is one of the largest makers of corn dogs in the US, specializing in private label retail products and co-packing for other companies.
Karl Schledwitz, chairman and CEO, said in a press release that all of the current employees would be offered the opportunity to continue working at the plant as part of the Monogram team. Schledwitz also said the company plans to invest up to $5 million in the Hinsdale facility in the coming year to increase production and add employees.
According to David Dunavant, Monogram's CFO, the company raised $12.5 million in new equity to facilitate the deal, mostly from investors residing in the Memphis area. The company was purchased from Philip and Milton Smith, third-generation owners of the family business that was founded in 1945.
"The Hinsdale acquisition is a perfect fit for Monogram,'' Schledwitz said. "Our goal is to integrate Hinsdale into Monogram's manufacturing and sales systems as Monogram grows its position among the nation's leading manufacturers of processed meats."
1Sysco, US Foods: 'Show us the witnesses'
2Slideshow: The meat industry's Sweet 15
3AI infects third California poultry farm
4Tyson Foods bearer of branded business strategy
5Wayne Farms files for IPO
( more )
1VIDEO: Sous vide line over time
2Sysco, US Foods: 'Show us the witnesses'
3Wayne Farms files for IPO
4Strike is on at Olymel pork plant
5Koch to invest $7.5 million in Alabama chicken plant
1Seaboard shareholders to vote on HSUS proposal
2USDA extends dietary recommendations comment period
3Editors Blog: Still waiting for hand-held meat pies
4Antibiotics use in livestock on the rise around the world
5American Foods, Kings Command merge
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Oberon's status as king of the elves comes from the character of Alberich (from Old High German alb- "elf" and -r�h-, "ruler", "king"), a sorcerer in the legendary history of the Merovingian dynasty. In the legend, he is the otherworldly "brother" of Merowech, whose name is the eponym of the Merovingians. Alberich wins for his eldest son Walbert the hand of a princess of Constantinople. In the Nibelungenlied, a Burgundian poem written around the turn of the 13th century, Alberich guards the treasure of the Nibelungen, but is overcome by Siegfried - from Wikipedia
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