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Because if there's one thing the entertainment world is lacking, it's television adaptations of bestselling fantasy novels.
Justin Beiber's star is rising and there's nothing that can be done to stop it. But, at least, it can be stalled.
Andy Whitfield tragically cannot return to the role of Spartacus because his cancer has come out of remission, but producers are committed to finding a new actor.
AMC President Charlie Collier says season four of "Breaking Bad" will take it to the next level and be "truly phenomenal." Also, where's the zombie apocalypse headed from here?
Dude. Last night's Mega Millions drawing boasted a $355 million jackpot, and a piece of that could have gone to you if you played the numbers from 'Lost.'
Pepsi has won the war to inundate Simon Cowell's new talent show, "The X Factor," with their iconic branding. Tough titties, Coke.
Get some juicy intel from Det. Sammy Bryant himself.
Damian Lewis has been cast in Showtime's "Homeland" as a soldier who returns home after ten years in Iraqi prison. He'll star opposite the totally-believable-as-a-CIA-agent Claire Danes, who will be playing a CIA agent.
So while most Americans are struggling to make ends meet this holiday season, Morgan is out there buying new organs. Typical Hollywood.
Matthew Senreich comments on the latest batch of Star Wars jokes and gives us a preview of the show's fifth season.
This is a touchy subject whenever I bring it up around here, but "Dexter" is an uneven show. Now, Scott Buck is ready to wash the turd-like taste of Season Five out of our mouths.
As it turns out, Huston is the grandson of famed director John Huston, and the nephew of actress Angelica Huston. Looking back, the resemblance is uncanny. You can really see it in his eye.
It's been said that only Nixon could go to China. Well tell that to Big Bird, bitch.
They've taken television by storm with their hour-long dramas, and now AMC is preparing to run a train. The network gave a series order to "Hell On Wheels," a drama about the construction of the transcontinental railroad.
Eminem a.k.a. Slim Shady a.k.a. Marshall Mathers is stepping into the ring with "Sons of Anarchy" creator Kurt Sutter for new boxing drama, "Southpaw." Dreamworks bought the pitch in the room, and not just because the rapper stared at them intimidatingly.
Ethan Hawke is in talks to slum it on Fox with the procedural drama Exit Strategy. The high octane successor to "24" will star Hawke as the leader of an elite team that helps retrieve CIA agents from missions gone awry.
And the winners are…
This show seems to write itself, as officers advise the producers of strange real cases they've investigated. Rookie officer Ben Sherman gets a surprise in a seemingly routine domestic disturbance.
David Hasselhoff will do anything. ANYTHING. So it came as no surprise when he scored a reality show on A&E. Now the network has pulled the show after only two episodes. Keep in mind that this is the channel that has found success with a show about raiding storage units.
When Ricky Gervais hosted the Golden Globes earlier this year, he kept saying he'd never be invited back. He let loose with celebrity roasting, but now he is coming back to host again on January 16. Gervais told a conference call full of reporters that he plans to be even bolder with his jokes this time.
Will The Office bring in Billy Connolly or Sandy Duncan to take over Dunder Mifflin from Steve Carell? Creator of the British Office and executive producer of the American one, Ricky Gervais said we're all thinking wrong.
Just to put it in perspective, remember that political blog you started back in college? It received six total clicks, four of which were from you at different machines around the computer lab. Multiply that times a million, and you've got the same numbers that AMC is putting up.
Good news for people who like serial killers and ridiculous plots (I kid because I love). Showtime has renewed "Dexter" for its sixth season.
If I had a dime for every project that Steve Carell has sold I'd have enough dimes to put into a sock and beat my mailman. Speaking of mailmen, Steve Carell has sold a post office comedy to NBC.
Dani Pudi plays the character on "Community" who provides most of the show's self-referential meta humor. So it makes sense that Abed is responsible for a stop-motion animated episode in the tradition of the Rankin Bass specials.
Frank Darabont has liquidated the entire writing staff of "The Walking Dead" and plans on utilizing freelancers for the show's second season.
A former stage actress, ballerina, and one-time resident of the Czech Republic, Winter Ave Zoli is best known these days as the hard-headed porn star sweetheart of bearded biker outlaw Opie Winston on FX's leading series "Sons of Anarchy." And if you have a hard time picturing this tousle-haired beauty as the type who'd get down on camera for a quick couple hundred, it's all the better; the contrast between Zoli's disarming look of wide-eyed innocence and the seedy lifestyle played out by her on-screen alter ego is exactly what makes her character a thrilling fixture in the series.
A word from Winter: "Lyla and Opie are drawn to each other because they both have this sort of sweet sadness."
More pics of Winter after the jump…
Stoners, get ready to be happy. Adult Swim has picked up 12 episodes of "NTSF:SD:SUV" or National Terrorism Strike Force: San Diego: Sport Utility Vehicle."
When "Lost" was winding down, I had two big questions. Where the hell is Walt, and what embarrassing roles will Jorge Garcia have to play going forward? Hopefully, he won't have to at all because there's news this morning that he's re-teaming with J.J. Abrams.
Remember the classic "Rudolph the Red-Nosed Reindeer" Christmas special with the herky-jerky animation? If you don't, you're a communist. Even so, you might appreciate that "Community" is planning a similar stop-motion animation holiday spoof.


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Psoriasis After Swallowing Precum What Are The Chances Of HIV
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
HIV Infection via swallowing blood?Dear Dr. Bob,My husband and I are aid workers in Tanzania, where the prevalence of AIDS is greater than 10% in the city we work (Dar es Salaam). He was involved in a car accident on Friday and the taxi driver's blood went into his mouth. He has no...
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation...Hi Noel,Your husband's HIV-acquisition risk remains extremely slight. There is no indication the cab driver was virally enhanced. You don't mention how Read more »
Accidentally Swallowed Cum of An HIV+Hello Dr.Recently I had unprotected sex with my boyfriend. He got himself tested for HIV with ELISA... Read more »
swallow or spit (SPIT OR SWALLOW, 2009)hi, is it safe to swallow the cum from a guy? some says its okay but I want to be assured Read more »
Women and HIV/AIDS...than womenstill have HIV in the US, women are catching up. In some countries, HIV+ womenoutnumber HIV+ men. The proportion of HIV/AIDS cases among women has more than tripled from 8percent in 1985 to an alarming 27 percent in 2008. That means... Read more »
HIV/AIDS Among Hispanics/Latinos... The HIV epidemic is a serious threat to the Hispanic/Latino community. While Hispanics/Latinos 1 represented approximately 15% of Read more »
What Are the Symptoms of HIV and AIDS?... When it comes to the symptoms of HIV/AIDS, there are three major points to keep in mind: There's a big difference between the symptoms of HIV and the symptoms of advanced Read more »
How to Spot HIV/AIDS Fraud... What Is HIV/AIDS Fraud? Warning Signs of an HIV Fraud Common Sense About Unproven Treatments Questions You Should Ask Take Your Read more »
Connect With Others
Precum and HIV
Posted by Anonymous...I got HIV at the end of August. I had unprotected sex with someone who told me he was "safe". The interesting thing is that he never Read more »
Am I Infected
Posted by delhiguy, 3 RepliesI am 30 YO guy. Worried that I may have got infected. I met this friend of mine on 5th of Dec 2010 which was just a causual meeting after 5 years. After having drinks she started touching me and I got aroused and we end up mating. While in act, she... Read more »
Posted by sadface, 2 Replies...Oral sex..if I was to "swallow" does that put me at risk for Hiv?? Thanks all.. Sf Read more »
Swallowing Cum
Posted by Anonymous, 2 Replies...is married and we have been having an affair for a little over 2 years and he uses a condom for anal but now I have started swallowing his cum during oral sex. Read more »
Resource Centers
Guides for People With HIV

subset: commoncrawl


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Featured Event
Danilo Pérez and Panama 500
8:00 pm - 9:30 pm
Event Calendar
Today - Wed, Apr 1, 2015
Annual Lip Sync! Performance
The annual Amherst tradition known as Lip Sync will take place Wednesday April 1 at 9 p.m. in Johnson Chapel. Watch your classmates perform for a chance to be at the top of their class for this year's room draw! This family friendly event is open to the entire campus community. If you are unable to attend the festivities, it will be streamed live for members of the Amherst community. Click here to log in: https://www.amherst.edu/mm/316719 For more informatoin contact email@example.com
Prepare to have fun!
Danilo Perez Masterclass
Danilo Perez will hold a music masterclass at 4 p.m. His concert will be at 8 p.m. the same evening.
On his new Mack Avenue release "Panama 500", Danilo Pérez adds his voice to the tributes with a stunning portrait of his native land, its storied history, rich culture and fierce struggles.
"Panama 500" is Pérez' most ambitious project to date, the furthest evolution yet of what the pianist/composer calls "three-dimensional music." His blend of influences makes him the ideal musical chronicler of his country's history: already a land bridge between the Americas with a vibrant indigenous culture, Panama also began to absorb European culture into its own following Balboa's arrival. Pérez similarly weaves together jazz and Pan-American folkloric traditions with influences from European classical music.
"[Panama 500 is a] distillation of ideas…mingling elements of classical form, jazz flexibility and Latin-American folk melody…impressive for both its design and its execution, and for the strong implication that those two qualities are inextricable, even indivisible."
-The New York Times
"Where Did 'Organic' Come From?: The Unpredictable Past of Natural Food"
This talk, by Andrew Case of Washington College, explores the shifting environmental and cultural values of the organic movement in the postwar U.S. through the story of publisher and natural health enthusiast J.I. Rodale. A transformational figure in the history of environmentalism, Rodale began publishing about health and farming in 1942 and became the popular face of the organic movement in the late 1960s. Eccentric enough that people did not always take him seriously, his story nonetheless raises critical questions about the limits of the marketplace as a site of equitable and sustainable environmental reform, particularly given the international and global scope of the issues at stake.
This event is sponsored by the Eastman and Lamont Lecture Funds.
Performance Studio Concert, Rm 3
Amherst College Students perform a short, mixed concert in ARMS, Room 3.
Danilo Pérez and Panama 500
Panama 500 is Pérez's most ambitious project to date, the furthest evolution yet of what the pianist/composer calls "three-dimensional music." His blend of influences makes him the ideal musical chronicler of his country's history: already a land bridge between the Americas with a vibrant indigenous culture, Panama also began to absorb European culture into its own following Balboa's arrival. Pérez similarly weaves together jazz and Pan-American folkloric traditions with influences from European classical music.
This event is free and open to the public. Tickets may be reserved by emailing email@example.com.
This event will be at Buckley Recital Hall, located in the Arms Music Center at Amherst College.
"Raising Ms. President: Women in Politics," A Conversation with Babson College President Kerry Healey
The Amherst Political Union is proud to bring Babson College President Kerry Healey to Amherst on Wednesday, April 1.
President Healey is not only the first woman to serve as the President of Babson, but she also served as the lieutenant governor of Massachusetts under Mitt Romney, and served as a top aid during his presidential campaign.
Additionally, President Healey was appointed by Secretary of State Condoleezza Rice as a founding member of the Executive Committee of the U.S. Department of State's Public-Private Partnership for Justice Reform in Afghanistan (PPP), a position to which she was reappointed in 2009 by Secretary of State Hillary Rodham Clinton. President Healey is also a fellow at the Harvard Kennedy School's Institute of Politics and Harvard's Center for Public Leadership.
With her immense experience, President Healey will discuss political parity and the role of women in politics. She will also provide her insights on the 2016 election. It's sure to be an exciting and informative event! Hope to see you there!
Amherst Lip Sync
The grandest competition of them all is upon us. No, not the Super Bowl. Not the Olympics. Not the Hunger Games. Lip Sync. That's right, everyone's
favorite (faux) singing and dancing competition has arrived, and the rights to room draw glory will be on the line. Come see your closest friends and unknown peers strut their stuff, procure their props and sync their lips so they can turn that bottom-pick dud into a top-of-the-list stud.
Tomorrow - Thu, Apr 2, 2015
Russian Table - Fridays from 12:00 - 1:30, Spring 2015
Join us for Russian conversation and cameraderie each week of the semester (except for Spring Break) on the Mezzanine Level of Valentine.
German Film Series: "Die Mörder sind unter uns"
Two screenings, at 4 and 7:30 p.m.
"The Murderers Are Among Us" (Wolfgang Staudte, 1946; 85 min.)
The first feature-length film produced in Germany after World War II: a traumatized German soldier returns to a Berlin in rubble, only to encounter his former superior officer, a war criminal who has quickly reestablished himself as a successful factory owner. Shown by kind permission of the DEFA Film Library, University of Massachusetts Amherst.
"The Challenge of World Music for the Creative Musician" by Ned Rothenberg
The Amherst College Department of Music presents a lecture/workshop by clarinetist, composer and improviser Ned Rothenberg titled "The Challenge of World Music for the Creative Musician" on Thursday, April 2, at 4 p.m. in Room 3 of Arms Music Center at Amherst College.
For musicians and nonmusicians alike, Rothenberg's presentation addresses an important question: How can the Western composer/improviser address philosophical, technical and aesthetic issues that arise from the consideration of foreign traditions in a way that isn't superficial or exploitative? The event is free and open to the public.
Ned Rothenberg has been internationally acclaimed for both his solo and ensemble music, presented for the past 33 years on five continents. He performs primarily on alto saxophone, clarinet, bass clarinet and the shakuhachi, an end-blown Japanese bamboo flute. His solo work utilizes an expanded palette of sonic language, creating a kind of personal idiom all its own. In an ensemble setting, he leads the trio Sync, with Jerome Harris, guitars, and Samir Chatterjee, tabla; works with the Mivos string quartet playing his Quintet for Clarinet and Strings; and collaborates around the world with fellow improvisors. Recent recordings include this "Quintet," "The World of Odd Harmonics," "Ryu Nashi" (new music for shakuhachi) and "Inner Diaspora," all on John Zorn's Tzadik label, as well as "Live at Roulette" with Evan Parker, and "The Fell Clutch," on Rothenberg's Animul label.
Later the same day, Rothenberg's group Inner Diaspora performs on the Magic Triangle concert series at 8 p.m. at Bezanson Hall at the Fine Arts Center at the University of Massachusetts Amherst. Details are available at https://fac.umass.edu/Online/NedRothenberg.
For more information, contact Professor Jason Robinson at (413) 542-8208 or email@example.com.
Photo credit: Caroline Forbes
Audrey St. John talk, Rigidity Theory for Robotics, Drug Design and CAD
When designing a bridge, how can we minimize the amount of building materials while maintaining stability? Are there computational tools that can help predict protein flexibility, a key component in drug design? Rigidity theory seeks to answer these questions by studying structural properties from mathematical and computational perspectives. This talk will discuss the fundamental questions considered by rigidity theory and its applications, including those in robotics, structural biology and Computer Aided Design for mechanical engineers.
State Violence and Black Dispossession in the Americas
Lecture by Keisha-Khan Y. Perry, Ph.D., Associate Professor of Africana Studies, Brown University in Pruyne Lecture Hall, 115 Fayerweather, Amherst College.
Mindfulness Meditation (Adi Bemak/Open)
Take some quiet time in the busyness of your week to practice mindfulness meditation, a proven tool to reduce stress and create greater ease of living. Join Adi Bemak, longtime teacher at The Center for Mindfulness at UMass Medical School and Valley Mindfulness in Northampton for this one hour drop-in class. There will be periods of guided instruction as well as time for discussion. This class is open to faculty, staff and students and no experience is required.
About the facilitator: Adi was introduced to mindfulness meditation in 1976 in Myanmar (formerly Burma) and has been a practitioner of mindfulness for almost four decades. She has been teaching mindfulness tools since 1993, and is a longtime teacher of Mindfulness-Based Stress Reduction (MBSR) at the Center for Mindfulness in Medicine, Health Care and Society at the University of Massachusetts Medical School in Worcester. Adi also teaches MBSR in western Mass. through Valley Mindfulness, and serves on the Teachers' Council of the Insight Meditation Center of Pioneer Valley. She offers courses and retreats for beginning mindfulness practitioners, college and university staff and faculty, seniors exploring aging and health issues, and mindful parenting. A Buddhist advisor at Mount Holyoke College, Adi also maintains a mindfulness-based psychotherapy practice in Amherst.
"Gods, Kings, and Lovers: Paintings from Courtly India": A Closer Look Gallery Talk
Focus on the delights of miniature painting in the exhibition "Gods, Kings and Lovers," with Yael Rice, visiting assistant professor of art and the history of art, and Chen Jiang '15. Refreshments will be served.
AAS Budgetary Feedback and Information Session
Come with questions, comments, or feedback about the student government funding and reimbursement process. We are here to listen and help! Unsure how to get funding for your activities? Come to learn more! Students only.
Sugar Jones Cookies and other refreshments will be provided.
Powerhouse Play-in
Come to the Powerhouse on Friday, April 3 at 8 p.m. for the first ever Powerhouse Play-In. Bring any instrument, grab some sheet music and play along! It will be a chance to create music with new people and explore tons of new genres like jazz, pop, broadway, choral and classical. Haven't played in awhile? Rusty instrument? Have no fear! Come and play!
Sheet music and snacks will be provided.
"The Lower Frequencies"
Written and Performed by Bryce Monroe '15
Directed by Peter B. Schmitz
Inspired by the novel Invisible Man by Ralph Ellison
The Lower Frequencies depicts the particular experience of a nameless narrator who must overcome his naïveté about the American Dream. This experience is brought to life through a series of vignettes which comment upon the socioeconomic injustices caused by enduring institutional systems that have muted the voices, camouflaged the bodies, and denigrated the lives of the black community in the United States.
The playwright and performer, Bryce Monroe, is a senior psychology and theater and dance double major at Amherst College. In addition to his passions in theater, he is an accomplished singer-songwriter and athlete. He hopes to develop his thesis into a professional production that not only entertains but enlightens audiences of the harsh realities of living in America as a black man.
Reservations are recommended; please call (413) 542-2277.
Pride Alliance Weekly Meeting
Please join us weekly for our Pride Alliance Meeting at 8:00 p.m. in the Queer Resource Center. We host weekly discussions, guest speakers, workshops and events, and the GAP (Gay Amherst Party). All are welcome and there is always food!
Ongoing Events
КИНЕТИЧЕСКИЕ РИТМЫ: The Dynamic Spirit of Russian Modernism
In 2014, the Mead Art Museum oversaw the installation of art in the Russian Center Art Gallery, a newly refurbished space in the Amherst Center for Russian Culture, located in Webster Hall. The exhibition on view, КИНЕТИЧЕСКИЕ РИТМЫ: The Dynamic Spirit of Russian Modernism, brings together works from the Thomas P. Whitney '37 collection that reflect the dynamic spirit of the artistic milieu of the first three decades of the twentieth century. Visit the link below for additional information about the works on view.
The Russian Center Art Gallery is located in the Amherst Center for Russian Culture, on the second floor of Webster Hall. Open Monday, Wednesday, and Friday from 10 a.m. to 3:30 p.m., as well as Tuesday and Thursday from 1 p.m. to 3:30 p.m.
Nature, Pleasure, Myth: Animals in the Art of Japan
This special exhibition explores the appearance of animals throughout different genres of Japanese woodblock prints, textiles and fashionable objects. From Japanese folklore to kabuki performances, from the embroidered robes of courtesans to fascinating "secret calendars," animals—domestic, wild and fantastical—offer a view into the "floating world" of Japan. On view at the Mead Art Museum February 7–June 28.
Tues, Wed, Thurs, Sun: 9 a.m.–midnight
Fri: 9 a.m.–8 p.m.
Sat: 9 a.m.–5 p.m.
Fifty Years of Shōwa Japan: The Photography of Kageyama Kōyō
The photographs of Kageyama Kōyō (1907–1981) document the changing urban landscape of Tokyo during the Shōwa imperial period (1926–1989). Kageyama captured scenes of the city as it rebuilt after the Great Kantō Earthquake of 1923, underwent militarization in the 1930s, endured the years of World War II and its aftermath, and as it developed into a global metropolis. On view at the Mead Art Museum February 7–June 28.
Tues, Wed, Thurs, Sun: 9 a.m.–midnight
Fri: 9 a.m.–8 p.m.
Sat: 9 a.m.–5 p.m.
Then & Now: The Changing Arctic Landscape
If a picture is worth a thousand words, "Then & Now: The Changing Arctic Landscape" —a traveling exhibition from the University of Alaska Museum of the North—speaks volumes about glacial retreat and the consequences of climate change in the Alaskan Arctic.
On view at Amherst College's Beneski Museum of Natural History through April 19, "Then & Now" features photographs and media presentations that illustrate the startling effects of climate change, provide context about the Arctic ecosystem and illuminate the behind-the-photo stories of the consequences of climate change for Arctic indigenous peoples.
Open Tue–Fri, 11 a.m.–4 p.m. | Sat & Sun, 10 a.m.–5 p.m.
Gods, Kings, and Lovers: Paintings from Courtly India
Drawn entirely from the Mead's permanent collection, this exhibition explores the essential role of painting in the lives of India's elites, looking especially at the convergence of human and divine in nine exquisite works created for Muslim and Hindu patrons between the seventeenth and nineteenth centuries. On view at the Mead Art Museum February 14–July 5.
Tues, Wed, Thurs, Sun: 9 a.m.–midnight
Fri: 9 a.m.–8 p.m.
Sat: 9 a.m.–5 p.m.
Nathaniel Lieb: "Driving to Amherst"
Nathaniel Lieb, artist-in-residence in the Department of Art and the History of Art, exhibits a multimedia installation in the Eli Marsh Gallery and gives a lecture about his work on Thursday, March 12, in Pruyne Lecture Hall, followed by a reception in the gallery. Note that the exhibition will be closed during spring break (Saturday, March 14, through Sunday, March 22) and will reopen on Monday, March 23. The exhibition closes April 3. It is free and open to the public.
Gallery Hours:
Monday–Friday, 10 a.m.–4 p.m.
Sunday, 12–4 p.m.


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By Catholic Online (NEWS CONSORTIUM)
9/26/2012 (2 years ago)
Catholic Online (www.catholic.org)
According to a British-based Syrian monitoring group, at least 30,000 people have died in Syria's 18-month-old uprising. Even more horrific is the fact that more than half of the victims counted were killed in the past five months.
By Catholic Online (NEWS CONSORTIUM)
Catholic Online (www.catholic.org)
9/26/2012 (2 years ago)
Published in Middle East
Keywords: Syria, civil war, uprising, fatalities, civilian deaths
LOS ANGELES, CA (Catholic Online) - The uprising against Syrian President Bashar al-Assad, which began peacefully in March of last year as peaceful protests, has since plunged the nation into civil war since rebels took up arms against a security force crackdown.
The head of the Syrian Observatory for Human Rights, Rami Abdulrahman reports that 30,716 people have been killed. The vast majority of the casualties, at least 21,534, have been civilians. A network of activists based around Syria have not divided their civilian death count between unarmed residents and those who have joined the rebels.
The pro-opposition Observatory says that 7,322 soldiers fighting for Assad were killed, while at least 1,860 army defectors have died fighting for the opposition.
"By looking through our figures, we noticed that the toll has been rising. Between 50 and 60 percent of those killed died in the past five months," Abdulrahman said.
Official figures from Syrian authorities have said that more than 2,600 members of the security forces have been killed, but have not given a casualty figure for several months.
In spite of the growing death toll, international powers are stuck in a diplomatic stalemate. Western powers and Gulf Arab states back the opposition, while Russia, China and Iran are backing Assad.
The violence rose rapidly in recent months as rebel forces spread, taking the fight across the country and into Syria's two major cities, the capital Damascus and business hub Aleppo.
Assad claims that his opponents are "terrorists" backed by foreign powers and has responded with heavy bombardment, including the use of fighter jets and helicopter gunships.
St. Isidore the Farmer
St. Christopher
St. Florian
St. Clare
St. John the Baptist
St. Brigid of Ireland
St. Joseph of Cupertino
St. Joseph
St. Ann
St. Barbara
St. Matthew
St. George
St. Mark
St. Anthony
St. Francis of Assisi
St. Jude
St. Benedict
St. Gerard
By Abigail James (NEWS CONSORTIUM)
In response to a growing conflict in Yemen, the Arab leaders from different countries have agreed to form a joint military force. This decision is mostly aimed toward fighting jihadists and Islamist extremism that has invaded Iraq and Syria and is making moves toward ... continue reading
By Abigail James (NEWS CONSORTIUM)
The Unites States has officially breached a silent agreement with Israel that had been in place for decades. The Department of Defense declassified a top-secret document that details Israel's nuclear program. LOS ANGELES, CA (Catholic Online) - Israel never formally ... continue reading
By Catholic Online (NEWS CONSORTIUM)
Saudi Arabia-led airstrikes in Yemen are targeting military installations held by the Shia rebels. The militant factions swept into the country's south and drove Yemeni President Abed Rabbo Mansour Hadi to flee by sea. LOS ANGELES, CA (Catholic Online) - Hadi was ... continue reading
By Catholic Online (NEWS CONSORTIUM)
The momentous divide between Sunni and Shia Muslims in the Middle East has turned into open conflict in Yemen. There are widespread fears that this will draw other nations into a much wider war. LOS ANGELES, CA (Catholic Online) - A Sunni coalition of Arab states ... continue reading
By Catholic Online (NEWS CONSORTIUM)
Backed by other Gulf States and Egypt Saudi Arabia, Saudi Arabia launched airstrikes against Houthi militants in Yemen. The airstrikes were in response to the Yemeni president fleeing his palace ahead of advancing fighters. LOS ANGELES, CA (Catholic Online) - ... continue reading
By Catholic Online (NEWS CONSORTIUM)
The King Abdullah Economic City, or KAEC -- pronounced "cake," is being constructed by Saudi Arabia. The planned megacity in the desert will be slightly larger than Washington D.C. and home to approximately two million residents. LOS ANGELES, CA (Catholic ... continue reading
By Catholic Online (NEWS CONSORTIUM)
While the United States works with Iran for a comprehensive nuclear weapons treat, Iran's Supreme leader Ali Khamenei called for "Death to America" this past weekend. It was contradictory news as it came shortly after President Barack Obama appealed to Iran to ... continue reading
By Abigail James (NEWS CONSORTIUM)
The continuous efforts to get Israelis and Palestinians to reach a peaceful agreement on land has potentially reached its peak. The United States is edging closer to supporting the United Nations Security Council in forcing a final peace settlement, a lasting two-state ... continue reading
By Catholic Online (NEWS CONSORTIUM)
Israeli Prime Minister Benjamin Netanyahu, in a message posted on Facebook declared that left-wing non-governmental organizations, or NGOs and foreign governments were attempting to influence the upcoming Israeli election. He says that these entities intended to bus ... continue reading
By Abigail James (NEWS CONSORTIUM)
"We want, Allah willing, Paris before Rome and before Al-Andalus [Spain and Portugal], [and] after that we will blacken your life and blow up your White House, Big Ben, and the Eiffel Tower, Allah willing," Islamic State spokesman, Abu Muhammad al-Adnani warns in a ... continue reading


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Find a local stylist, colorist skin care expert, beauty specialist, and more!
Looking for a place to call home? We provide the space and essentials, so you can run your own business.
Expand under the A Suite Salon family. Come see the benefits.
© Copyright 2014 - A Suite Salon, Inc. We are a proud supporter of The Future of Small Business. Website Design by Green Group Studio


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Convenient size blue painted grain bin found in Pennsylvania. Wonderful strap hinges and iron hatch. Bin is multiple boards and bread board end lid. Paint appears to be later than the box maybe turn of the century. Box is sturdy ready for your recyclables or dog food. Bin is 26" high x 24" wide x 14" deep.
Item ID: B1850
If you are the pending buyer of this item, go to My Account to view, track and pay for this item.
North 2 South Antiques
Antiques and collectibles for every taste and price range, come on in and see!
|Freight (cost to be determined)
Price for shipping to USA change location


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Exterior View of all ultrex vs wood-utrex window?
If we use one all-ultrex window on front elevation will the exterior of this window look the same as wood-ultrex Marvin Integrity window? Will the window stand-out or be noticeable on the front elevation when the other windows will be Integrity Wood/Ultrex double hing windows?
Our front elevation is all brick with all the windows being 6' 2" in height and with GBGs, ( Marvin integrity Wood-ultrex double-hung windows)(painted white interior and stone white exterior)
One of these windows will be in a guest bathroom in the front of the house, so it is integral to the front elevation look.
We would like to use an all-ultrex window in this bathroom so as not to worry about water/condensation issues.
This window will be 2'8" wide x 6'2" high with GBG.(white interior and exterior)
Will the All-ultrex double hung window exterior look the same as the wood/ultrex double hung exterior when viewing the the front elevation from the driveway or street?
You need to go see both windows side by side in a showroom.
The wood/fiberglass window looks like a modern clad wood window and the all fiberglass window looks like a vinyl window, i.e., the elements are all flatter and narrower which results in interior extension jambs and stools that are about twice as deep.


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Korppoo - Korpo - situated in the town of Parainen - Pargas 1).
For centuries Korppoo was situated in the absolute center of the Swedish kingdom. That depended on sea transports.
The numerous sea routes crossing the Korppoo region made up a vital nerve system for the Swedish kingdom. In the course of time it became necessary to have people running pilotage services and beacons. The economical significance of the sea.
1). The town of Parainen - Pargas is the "largest" archipelago town in the world , when five municipalities (Parainen, Nauvo, Korppoo, Houtskari and Iniö) in Finland became one in 1.1.2009. With more than 10 000 islands and islets.
Entrepreneurs in the islands of Korppoo - Korpo:
|Villa Walldén. Holiday cottage Luxury seaside house in the Archipelago of Turku - The island of Korppoo. Beautiful surrounding, Accessible by car. Read more...
|Strömma Gård. Modern spacious cottages fully equipped for year round use. Five individual cottages in a bay of south western Korppoo. Read more...
Restaurang Buffalo. Excellent service. Professional menu, to be enjoyed in the relaxing milieu. Music evenings
Wattkast cottages. Comfortable seaside cottages in the Archipelago of Turku - The island of Korppoo. Reachable by car. Read more...
Faffas Bed & Breakfast
Öster-Retais 23, 21710 Korpo, Finland
Hotel Nestor
Events, accommodation
Phone: +358-40-7213148
|Hjalmars restaurant & Pub : Korppoo - Stabshuset, Address Kauppamiehentie 1
Phone. +358 (0)2-463 1202
|Korpoström - Archipelago Centre. Island of Korppoo. Accommodation, Restaurant, etc. Phone: +358 207 118 722
Nature Experiences
Other Services
myKayak. We are specialized in Sea Kayaking activities and teaching Sea Kayak building.
Lenas Sightseeing. Sightseeing in Turku and its surroundings with an authorized guide. Read more...
|Aavameri Open-Air Adventures / seakayaking
skiing tours
hiking tours
theme excursions
Phone: +358-40-7350025


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Events for May 8, 2014
Vegas Uncork'd 2014
When: From 05/08/2014 to 05/11/2014
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Every Trump Bride gets to experience lavish treatment, personalized planning and...Read More
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Give your friends and family the gift of luxury. Our Trump Collection Gift Cards are usable at any Trump Hotel. http://t.co/C11gJjUHpWRead More
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Trump International Hotel Las Vegas Hosts Autism FundraiserRead More


text: http://www.archlinux.org – Dave Reisner wrote: systemd and udev have been merged upstream. We will still ship them in separate packages. However, in order to keep things simple, udev will now be part of a package called systemd-tools. This package contains several other standalone tools which can be used without systemd. The astute reader will note that this also means the entirety of systemd is available in the core repository. Please replace udev with systemd-tools when prompted. If you upgrade the linux package at the same time, you may see an error during initramfs creation that the udev hook is not found. After the (Distributions)


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Apache Kafka Jobs in the South East
Jobs 1 to 1 of 1
Senior C#, Hadoop Engineer - Newbury
Newbury, Berkshire -
Evolution Recruitment Solutions
Strong coding exposure in C# Hadoop ecosystem (HDFS, HIVE, PIG etc) Real world exposure of Hadoop-based applications through the entire product lifecycle. Openness to Agile practices such as Scrum, continuous integration, continuous delivery. Strong commitment to quality - Unit Testing, TDD/BDD... HBase, Cassandra, Redis, Kafka... Apache Spark, Scala. Apache...
Salary: 50,000-55-0000Posted: 3 days ago


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If you have questions about the recent Anthem data breach, please visit anthemfacts.com for the most up-to-date information. The University of Colorado will continue to work with Anthem to provide you timely information related to the breach and resources to protect your personal information.
Alternative Work Schedule Information
Use this page to access:
- Alternative Work Schedule Guidelines
- Work-at-Home Procedures


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This page contains Star Wars Hints for NES called "Extra lives" and has been posted or updated on Sep 3, 2006 by steve2010. Let us know what you think of this Hint by thumbs voting.
Boxshot / Details
- Developer: Beam Software
- Publisher: JVC Digital Studios
- Genre: Action Platformer
- Release Date: Not Set
- ESRB: Not Set
- Other Platforms
Extra lives
Find the wall in Obi Wan's cave that appears slightly different than the other walls. Jump left into the wall to find two bonus lives.
All Hints
From: rock7
From: steve2010
From: halfPlulp
Back to all Cheats
From: bodb
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JONESBORO, Ark. (3/26/15) The Arkansas State Athletics Department has announced season and individual-game ticket prices for the Red Wolves' 2015 football home campaign, which kicks off Sept. 12 against SEC-East champion Missouri at a new-look Centennial Bank Stadium.
JONESBORO, Ark. (3/20/15) The Arkansas State football team wrapped up its first full week of spring camp Friday afternoon, donning full pads for the first time as it held its fourth practice at Centennial Bank Stadium.
JONESBORO, Ark. (3/13/15) The Arkansas State football team was back on the field late Friday afternoon for the first time since competing in the 2015 GoDaddy Bowl, holding its initial spring practice in shorts and helmets under rainy weather conditions at Centennial Bank Stadium.
JONESBORO, Ark. (3/3/15) The Arkansas State football team held its annual Pro Day Tuesday morning at Centennial Bank Stadium, and five former Red Wolves were put through various tests and drills by several National Football League (NFL) representatives as the 2015 NFL Draft approaches.
JONESBORO, Ark. (2/27/15) - The Sun Belt Conference announced its 2015 composite football schedule Friday, and three midweek nationally-televised games on ESPN2 or ESPNU highlight Arkansas State's league slate for the upcoming season.
JONESBORO, Ark. (2/8/15) Arkansas State fans in central Arkansas will have the opportunity to hear from Red Wolves head football coach Blake Anderson Tuesday, Feb. 10, when he will discuss A-State's 2015 signing class at a social event at the Arkansas State University System Office in Little Rock.
JONESBORO, Ark. (2/5/15) - Selected by the Arkansas State football coaching staff and players, senior Alan Wright (Cave City, Ark.) has been named the recipient of the 2014 Gary Withrow Award that is presented annually to the Red Wolves' outstanding offensive lineman of the year.
JONESBORO, Ark. (2/4/15) Fresh off leading Arkansas State to its fourth consecutive bowl-game appearance, head football coach Blake Anderson announced Wednesday that 24 players, including seven midyear transfers, from 11 different states have signed with the Red Wolves' program.


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As a sales manager, you need to set a good example for your team's behavior, writes Josiane Feigon. You also should focus on coaching, track key metrics and offer assistance to salespeople who are struggling. "Taking the time to coach low or mid-performers can pay off in big ways," Feigon notes.
View Full Article in:HeinzMarketing.com
Published in Briefs:


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These easy, one-dish breakfast casseroles will satisfy your entire table—and let you hit the snooze button a few extra times.
12 Epic Icebox Cakes to Eat All Summer Long
A classic potato salad that's creamy, crunchy, and tangy all at once, this summery side dish will be a favorite at your next barbecue or picnic.
Pretty purple and green beans add gorgeous color to this simple salad; use a mixture of different beans for a really beautifully composed dish.
Recipe: Blistered Bean Salad with Buttermilk Dressing


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Volunteer State Community College
2015 Catalog Available Online
Are You New to College? Welcome.
From NASA to the Vol State Classroom
Instructor Mike Welham uses his experience with space exploration to bring science home for Vol State students and kids in the community.
Vol State Named a "VETS Campus"
The state of Tennessee designation recognizes the Vol State commitment to student veterans.


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Unless Batman has some unforeseen reviving powers, there's a strong chance we won't be seeing Maggie Gyllenhaal in The Dark Knight Rises. But that's not stopping the actress from looking for her next big-budget blockbuster. She's since been seen in the indies Crazy Heart and most recently, Hysteria, but now Variety reports she's set her sights on a tentpole, as she's in talks for the Sony action film White House Down.
If talks go through, the actress would join Channing Tatum in the Roland Emmerich film, after news last night that Jamie Foxx may serve as President of the United States. Gyllenhaal's role would have her play a "patriotic" (duh) Secret Service agent tasked with protecting the President.
Described in the vein of Die Hard and scripted by James Vanderbilt (Zodiac, The Amazing Spider-Man), the film follows a single father and Secret Service agent (Tatum) who is tasked to protect the president when baddies invade the White House with little chance of escape.
I can't quite picture Gyllenhaal getting down and dirty in the action, but she's a fine addition to this ensemble with each actor certainly bringing a different vibe. Then again, I can't imagine their talents will be fully exercised with Emmerich at the helm, but there's room to dream. One can next see Gyllenhaal in Won't Back Down this September.
White House Down hits theaters November 1st, 2013.
Since any New York City cinephile has a nearly suffocating wealth of theatrical options, we figured it'd be best to compile some of the more worthwhile repertory showings into one handy list. Displayed below are a few of the city's most reliable theaters and links to screenings of their weekend offerings — films you're not […]
Every week we dive into the cream of the crop when it comes to home releases, including Blu-ray and DVDs, as well as recommended deals of the week. Check out our rundown below and return every Tuesday for the best (or most interesting) films one can take home. Note that if you're looking to support […]
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Crash victim wanted to help others
A Mendon woman left for dead by a hit-and-run driver on Route 4 Friday night was a mother, beloved girlfriend and nursing student who was preparing to work with the elderly, according to her friends and boss.
At 45, Drury Morgan had a 17-year-old son taking classes in Woodstock, but she was about to begin a career she had long wanted to pursue as a licensed nursing assistant, according to boyfriend Andy Blanchard of Mendon.
She was taking courses at Stafford Technical Center and she was almost done. She wanted to work in a nursing home, said Blanchard, who struggled to maintain his composure during a telephone interview Saturday. She said it was what she was put here to do because she really loved it.
Vermont State Police are still looking for the driver of one of the two vehicles that struck Morgan as she crossed Route 4 at 5:18 p.m. Friday.
Police said she was struck first by a dark-colored station wagon or hatchback possibly green that was described as being similar to a Subaru. The driver of this vehicle drove away without stopping, police said.
Morgan was then hit by a Honda CR-V driven by Joseph Ferrara of Huntington Station, N.Y., who stopped after the hitting Morgan.
Despite the efforts of rescuers who tried to resuscitate her, Morgan died at the scene, police said.
No charges were brought against Ferrara, 50, who immediately called police after the accident.
But a state police sergeant at the scene Friday night said the driver of the other car would face, at minimum, a criminal charge of leaving the scene of a fatal crash.
No additional information was released by the police Saturday and the trooper investigating the crash couldnt be reached for comment.
Blanchard asked anyone with information about the crash or the identity of the driver to come forward.
A normal person wouldnt even leave a dog or cat on the road, he said. Im very, very angry. Im sure it was an accident, but Im also sure they knew they hit her. I only hope and pray that they come forward.
Investigators said Morgan was wearing dark clothing and may have been drinking before she crossed the three-lane highway.
But her boss at the Mendon Mountain View Lodge, where she had gone to pick up her paycheck, said Morgan acted responsibly Friday afternoon.
General manager Patrick Boandl said that based on the observations of Mountain View staff, Morgan may have been drinking before she arrived by bus at the lodge. But he said she drank soda in the lounge for 45 minutes before she left.
Boandl said Morgan was crossing the highway to get to the bus stop on the other side when she was struck and killed.
She was a nice lady and a good worker and were all very sorry, Boandl said.
Morgan worked as a waitress and housekeeper at the lodge. Boandl had hired her in October to help reopen Mountain View, which had been empty and on the market for seven months.
Boandl said the staff at the lodge planned to attend Morgans funeral, which has not yet been scheduled. He said the lodges owner plans to donate to a fund being established for Morgans son.
@rutlandherald.comMORE IN This Just InNEW YORK Emergency workers found a body Sunday in the mass of rubble left behind by an apparent... Full StoryHALIFAX, Nova Scotia An Air Canada plane made a hard landing short of the runway at the Halifax... Full StoryWASHINGTON The National Security Agency considered abandoning its secret program to collect and... Full Story
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Mindingall honored in City of North Miami
Miami-Dade School Board Member Dr. Dorothy Bendross-Mindingall (D-2) was honored for her public service at the City of North Miami's Celebration of Women event held March 19, at the Museum of Contemporary Art (MOCA) in North Miami. The annual event is held in honor of National Women's History Month, which recognizes and celebrates the contributions of women in our
Dreaming Big
Young local filmmakers use their short films to inspire other youth
Elijah Wells didn't think much of having one of his videos showcased at the Second Annual White House Student Film Festival on March 20 in Washington, D.C. until he actually came face to face with President Barack Obama. The 17-year-old filmmaker was chosen from a pool of 1,500 high school students nationwide to screen his video, "Giving Back Through My Lens," which is about giving back to his community in Overtown by teaching youth about film production.
NFL players to help raise money for CHI
Fundraiser will assist 40-year medical facility
When celebrities like NFL professional athletes Robert Bailey and Adewale Ogunleye hit the links on March 27, they will be swinging with a greater good in mind. The annual Robert Bailey/Glen Rice/Adewale Ogunleye Celebrity Golf Tournament raises funds for a variety of programs at Community Health of South Florida Inc. (CHI).
OneUnited Bank to become canvas for mural
A unique partnership to transform the OneUnited Bank building into a public work of art launched March 11 in Liberty City. The bank and the Miami Children's Initiative (MCI) in conjunction with Liberty City Renaissance have partnered to present the OneUnited Mural Project, a community youth development and beautification program providing arts enrichment through STEM (Science, Technology, Engineering, Arts, Math) education.
Lifestyle Happenings
Inner City Children's Touring Dance will have free Introductory Classical Ballet Workshops for girls ages 6-8 and 9-12 on Monday and Wednesday evenings. Call 305-758-1577 or visit www.childrendance.net. Sisters Empowerment Circle nvites ladies 45 and over with an interest in laughter, learning, developing new friendships, social networking, traveling, and sharing life's experiences in a comfortable atmosphere. Call 305-9345122/.
Public spaces challenge seeks ideas by April 1
The Miami Foundation's is seeking creative minds to submit ideas for its 2015 Public Space Challenge — just respond by April 1, no fooling. The foundation has a budget of $305,000 to fund your ideas about what you would do to create, improve and activate public gathering places like parks, libraries, plazas and playgrounds in Miami-Dade. Anyone — individuals, groups, agencies, nonprofits or companies — can submit ideas at ourmiami.org/challenge.
Falcon player gives back to community
Devonta Freeman of Liberty City to mentor Brownsville Middle students students
Dr. Dorothy Bendross-Mindingall, Miami-Dade School Board Member for District 2, recently organized a meeting with Brownsville Middle School students, administrators and Atlanta Falcons running back Devonta Freeman.
FMU track stars shine at the Hurricane Invitational meet
The Florida Memorial University track and field team had a strong showing at the Hurricane Invitational at Cobb Stadium on the campus of University of Miami in Coral Gables March 21. Brittany Starling ran an impressive performance in the 100-meter dash with a season-best time of
A dope boy's dream
As legend goes, Miami was built on dope money. Immortalized by filmmaker Billy Corben's cult classic "Cocaine Boys," the excess of these drug runners infused life into Miami's stagnant economy, according to the film's narrative. However, judging by the scarred low rises and dilapidated corner stores characterizing Miami's inner-city, that outpouring never reached our urban enclaves.
2015 Jazz in the Gardens
Sunday's lineup at Jazz in the Gardens
Heat fighting for their lives
The NBA playoffs are coming soon and with our Miami Heat fighting for their playoff lives, they are desperately trying to get in because as Kevin Garnett would say anything is possible. All of these top tier playoff teams have their own kryptonite. All of them even the seemingly unbeatable at times Golden State Warriors, Cleveland Cavaliers and Atlanta Hawks. There are some teams that just have other team's numbers.
Miami Gardens baseball clinics get funding
Children in Miami Gardens will now be able to take part in clinics and workshops to learn the game of baseball thanks to a $20,000 contribution from the Miami Marlins and the Jr. RBI (Reviving Baseball in Inner Cities) program. The program, launched in 2009 by Major League Baseball, provides opportunities for children ages 5 to 12 in underserved communitie
Lifestyle Happenings
Booker T. Washington Alumni Association will meet Thursday, March 19 in the BTW cafeteria at 6 p.m. Call 305-213-0188. Inner City Children's Touring Dance will have free Introductory Classical Ballet Workshops for girls ages 6-8 and 9-12 on Monday and Wednesday evenings. Call 305-758-1577 or visit www.childrendance.net.
Opa-locka Commission selects new city attorney
Vincent T. Brown to replace longtime lawyer Joseph S. Geller
Attorney Vincent T. Brown recently was sworn in as the new Opa-locka City attorney, replacing longtime City Attorney Joseph S. Geller of the Greenspoon Marder Law Firm. "I am truly honored to have been chosen and look forward to a productive relationship with the city," Brown said.
Black-owned firm to build catering site near station
D. Stephenson chosen for All Aboard Florida new restaurant project catering company
Fort Lauderdale-based D. Stephenson Construction Inc. has been selected to construct All Aboard Florida's Argentelle Catering & Special Events building near its future Fort Lauderdale passenger-train station. The facility will be located on land just west of the Florida East Coast Railway. The development is part of a greater master-planning initiative to spur opportunities downtown. Construction activities are expected to begin by the end of March.
Programs to receive millions in funding
Local summer, after-school providers see gains, losses
The Children's Trust has released its preliminary funding recommendations for after-school and summer programs for 2015. Big winners for agencies that support high Black populations are the Overtown Youth Center, Urgent Inc., Gang Alternative and Fanm Ayisyen Nan Miyami Inc. (FANM). But there were some notable losers such as Belafonte TACOLCY Center, the Miami's Children Initiative and Vision to Victory Human Services.
New report alleges fraud in M-DCPS disparity study
Another report questioning the veracity of the results of a 2013 Miami-Dade County Public Schools' disparity study conducted by MGT of America Inc. has emerged. The latest report, called "Leveling the Playing Field: Final Report of the 38 African American Subcontractors and their Contract Awards," comes after the Committee for Fair and Equitable Distribution of Public Contracts reviewed the school system's records.
Miami-Dade should not be Ferguson
One police officer in Ferguson, Missouri sent an email with a photo depicting President Barack Obama as a chimpanzee. Here, a Black man in the same city lost his job after a police officer accused him of being a pedophile as he was resting after a game of basketball. In the same city, a poor Black woman who parked her car illegally was forced to pay $550 in fines and still owes hundreds more from new fines and fees.
Dade Links help students learn about global discrimination
The Dade County (FL) Chapter of The Links Inc. and Florida Memorial University presented a successful dialogue and forum exploring the impact of worldwide discrimination. "Join the Conversation: Global Discrimination Against People of Color" is one of many activities
Commissioner Jordan honors FMU president
Miami-Dade County Commissioner Barbara J. Jordan honored Florida Memorial University's president, Dr. Rosalyn Artis, during the educational facility's Founder's Day celebration.


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Very few reports have investigated the role of cell cycle regulators as biomarkers in Basaloid Squamous Cell Carcinoma (BSCC) of the larynx, a definite morphologic, uncommon, very aggressive variant of squamous cell carcinoma. Lower expression of Ki67/Mib-1, a proliferation marker highly expressed in the majority of tumours, and p53, a tumour suppressor protein that can induce an arrest of the G1-S transition, was related to a better prognosis in laryngeal BSCC. In the head and neck, p27kip1, a member of the Cip1/Kip1 family of cyclin-dependent kinase inhibitors, has emerged as an independent prognostic factor, able to identify low-expressing tumours with unfavourable course. Up to date the role of this protein was never studied in BSCC. Aim of our study was to investigate the potential prognostic value of p27kip1 levels and their correlation with Ki67/Mib-1 and p53 expression in BSCC of the larynx.
The retrospective study group consisted of 15 male and 1 female patients, affected by laryngeal BSCC, ranging in age from 44 to 69 years (mean 58). The tumour originated from the supraglottis in thirtheen cases and from the glottis in the remaining three. Ten patients had metastatic cervical lymph nodes at presentation and were classified as N+. Post surgical stage was IV in four patients, III in nine, II in two cases and I in the remaining one. Follow-up ranged from a minimum of 5 months up to 9 years. Paraffin-embedded tissue sections of each laryngeal tumour were analyzed for p27kip, Ki67/Mib-1 and p53 expression by immunohistochemistry.
The immunohistochemical study showed p27kip1 expression in 40% of the patients with no evidence of disease (NED) and in none (0%) of the patients dead of disease (DOD), whilst p53 was expressed in 60% of patients in NED status and in 90% of patients in DOD status. Ki67/Mib-1 was positive in 80% of NED patients and in 100% of DOD patients. At multivariate analysis, performed by means of Discriminant analysis, low levels of p27kip1 expression significantly correlated with poor prognosis (P < 0.05).
p27kip1 protein has been shown to be a significant independent prognostic factor in laryngeal SCC. In our series of laryngeal BSCC the resulting data seem to confirm the clinical prognostic relevance of p27kip1 low expression, which directly correlated with biological aggressiveness and consequent shortened survival.
Basaloid squamous cell carcinoma (BSCC) is a definite morphologic, uncommon, very aggressive variant of squamous cell carcinoma (SCC), which is predominantly localized in the upper aero-digestive tract. In the head and neck region, this distinctive tumour has a strong predilection for extra-laryngeal sites, such as the base of the tongue, the hypopharynx and the supraglottic larynx.
This neoplasm shows a predominant basaloid pattern of growth intimately associated to areas of squamous cell carcinoma and/or adjacent regions of severe dysplasia and carcinoma in situ. It mainly affects men in the sixth and seventh decades of life and usually presents at diagnosis in advanced stages, with positive lymph nodes and/or distant metastases.
Since the first cases described by Wain et al [1] in 1986 a few hundreds of cases of BSCC of the aero-digestive tract, head and neck have been reported [2-24]; among them, about 70 cases are from larynx. It is a very rare variant of Squamous Cell Carcinoma (SCC) in this site and to our knowledge, only few isolated cases and very small series were described, with a maximum of 11 reported cases per series. The morphological features are sufficient to diagnose this tumour.
Recently various cell cycle regulators were investigated as biological markers of malignant potential, in an attempt to select which one might influence outcome and the effects of adjuvant therapies. Although conflicting data have emerged regarding the tumorigenesis and the clinical implications of cell cycle regulators in laryngeal SCC, p53 accumulation and Cyclin D1 over-expression have been consistently associated with poor prognosis [25]. The cyclin-dependent kinase inhibitor p27kip1is recognized as a negative regulator of the cell-cycle, since it blocks progression from the G1 to the S phase by binding cyclin E-CDK2 and inhibiting their activities. Reduced expression of p27kip1is related to progression in precancerous laryngeal lesions [26] and to cell proliferation and poor prognosis in laryngeal squamous cell carcinoma [27-33].
Few reports have investigated the use of cell cycle regulators as prognostic factors in BSCC of the larynx. Ki67/Mib-1 and P53 status were examined in two small series of BSCC of the larynx, resulting in absence of significant correlation of their levels with the clinical findings [34,35]. Recently, Marioni et al [21] investigated the expression of endoglin (CD105), a useful marker for identifying proliferating endothelium involved in tumour angiogenesis, in head and neck BSCCs and SCCs. They did not find any significant differences between the two groups. Rodriguez Tojo et al [22] retrospectively studied the immunoexpression of p53, Ki67/Mib-1 and E-cadherin in 11 cases of laryngeal BSCC, showing that the lower expression of Ki67/Mib-1 and p53 was related to the better prognosis and in all the cases E-cadherin was down regulated.
This study adds 16 new cases of BSCC of the larynx and investigates the expression and the potential prognostic role of cell cycle regulator p27kip1 together with its correlation with Ki67/Mib-1 and p53 expression in BSCC of the larynx.
Selection of cases
From the archival files of the Department of Biomorphologic and Functional Sciences, Pathology Section of the University "Federico II" of Naples, 16 cases of BSCC of the larynx were selected from January 1987 to December 2000 by a review of all laryngo-hypopharyngeal cancers reported. Only tumours showing a prominent basaloid pattern were included in the study. For each case, Hematoxylin-Eosin stain sections confirmed the original diagnosis. All cases fulfilled the basic histological features of BSCC [1].
The clinical records of the patients, i.e., site, TNM status, treatment and follow-up data (length of time since surgery and disease-free interval time to recurrence or death from surgery) are reported in Table 1.
Table 1. Follow-up of 16 cases of BSCC of the larynx
Our series of BSCC consisted of 15 men and 1 woman, whose age at diagnosis ranged from 44 to 69 years (mean age 58). All patients were heavy smokers, with smoking histories ranging from 10 to 30 packets/month. Symptoms at presentation were hoarseness, throat discomfort and dysphagia. Bleeding was an associate symptom in two cases only. The tumour originated from the supraglottis in 13 patients and from the glottis in the remaining three ones; ten patients were N+ at presentation (62.5%) and none of the patients had distant metastasis at the first examination. Post surgical stage was IV in four patients (25%), III in 9 cases (56.2%), II in 2 cases (12.5%) and I in the remaining patient (6.3%). Follow-up ranged from a minimum of 5 months to 9 years.
The primary neoplasm and all regional lymph nodes were surgically excised in 14 cases by either a total laryngectomy or supraglottic laryngectomy, depending on the size and location of the tumour; laser surgery was the preferred surgical approach in the remaining two patients. Eleven patients (68.7%) received postoperative radiotherapy
Ethical board and informed consent
The Italian law, with reference to the present research, does not provide for the Ethical Committee approval (see "Circolare del Ministero della Salute" no. 6 dated September 2nd 2002 and DLgs no. 211/2003).
Following the indication of Italian DLgs no. 196/03 (Codex on Privacy) a written consent was obtained from the alive patients.
4 μm sections for each case were pre-incubated in a microwave oven for 15 minutes in 10 mmol/L, 6.0 pH buffered citrate followed by the immunohistochemical procedure for Ki67/Mib-1, p53, and p27kip1. Ki67/Mib-1 (DAKO) diluted 1:50; p53 (BIOGENEX, San Ramon, CA,) diluted 1:300; p27kip1 monoclonal antibody (Transduction Laboratories, Lexington, KY) diluted 1:500. The conventional avidin-biotin complex procedure was applied according to the manufacturer protocol and the nuclei were counterstained with Mayer's hematoxilin and cover slipped with a synthetic, xylene based, mounting medium. Five different high magnification fields of represented areas of tumours were evaluated.
For each antibody only the neoplastic cells showing a definite nuclear staining were considered as positive and a semi quantitative evaluation was performed. High expression of p27kip1, p53 and Ki67/Mib-1 proteins was defined when >50%, >10%, and >10% of cell nuclei were positive, respectively; 0 and 1 were used to discriminate between low and high expressing tumours [36][37]. Two observers, blinded to the follow-up data of single cases, independently evaluated the results. As internal control for p27kip1 immunostaining, resting lymphocytes were used.
Statistical analysis
Discriminant analysis with a stepwise elimination of variables was performed to build up a predictive model of group membership based on observed characteristics of each case [38]. The model included the following variables as risk factors: age, tumour site, nodal status at presentation, adjuvant radiotherapy, p27kip1, p53 and Ki67/Mib-1 expression. In the statistical evaluation, the level of significance used was P < 0.05. The Wilks' lambda method was used for selecting the test set to assess the success of the discriminant function and for choosing the discriminant variables [39].
The Box's Test of Equality of Covariance Matrices was performed to test the assumption that the population under study had a multivariate normal distribution and equal variance-covariance matrices. The amount of explained variance was calculated by co linearity diagnostics and multivariate methods [40]. Finally, the sample was divided in two groups depending on the outcome: patients dead of disease (DOD) and patients with no evidence of disease (NED).
The whole analysis were performed by means of statistical software for Windows (SPSS 10.0, Chicago, III)
Ten patients (62.5%) died of disease (DOD) despite of salvage surgery and radiotherapy: among them, seven (63.6%) died in the first five years after surgery. Four patients (25%) have no evidence of disease (NED) actually. One patient (6.3%) had a successful treatment for a neck recurrence occurring in the first year after primary surgery and he was disease-free after 9 years. One patient (6.3%) is alive with disease (AWD), i.e. a neck recurrence occurred 4 years after the primary surgery, that was treated with associate radio- and chemotherapy.
Histologically, in nine cases (56.3%) the lesions were composed of basaloid cell nests showing an irregular lobular pattern of growth with a focal squamous differentiation; a small amount of squamous cell carcinoma was focally seen (Fig. 1A–B). The amount of squamous cell carcinoma was more conspicuous in the remaining seven cases (43.7%) that showed a combination of basaloid and squamous areas differently intermixed to each other, the basaloid component being widely prominent. The neoplastic cells had a typical scant cytoplasm, with round to oval, hyperchromatic or, occasionally, large and vesicular nuclei without prominent nucleoli. Mitotic figures and nuclear pleomorphism were frequently observed in all cases. Some basaloid nests displayed central necrosis without keratinization, whereas the cells at the invading front of the tumour tended to show peripheral nuclear palisade arrangements. Areas of hyalinization were present.
Figure 1. A Basaloid nests displaying central necrosis without keratinization. B Basaloid cell nests showing an irregular lobular pattern of growth with a focal squamous differentiation (arrow). C Immunohistochemical stain with Ki-67/Mib1 showing strongly positive tumour cells at the periphery of the nest. D Basaloid nest showing p27kip1 positive staining tumour cells toward the central of the nest, whereas the cells at the invading front of the tumour are negative. E p27kip1 positive staining in the areas of squamous cell differentiation.
There was no variability in the pattern of staining among the samples and the discrepancy between the two observers was negligible. Intratumoural variability was not present. Raw data with median % score and range for each antibody and each case are reported in Table 2.
Table 2. p27kip1, p53 and Ki67/Mib-1 antibodies range and median % score
The immunohistochemical study showed that p27kip1 was highly expressed in 40% of the NED patients and, strikingly, in none (0%) of the DOD patients, whilst p53 and Ki67 were highly expressed respectively in 60% and 80% of the patients in NED status and in 90% and 100% of the patients in DOD status (Table 3). At multivariate analysis high p27kip1 expression demonstrated to be significant (p = 0,01). No significant inverse correlation was found between p27kip1 expression and p53 or to Ki67/Mib-1 expression in DOD and NED patients groups. When the clinical series was globally evaluated, a slight trend for inverse correlation (P = -0,33 for p53 and P = -0.447 for Ki67/Mib-1) resulted.
Table 3. Immunohistochemical expression of p27kip1, p53 and Ki67/Mib-1
Interestingly Ki67 staining showed an intense signal in the tumour cells at the periphery of the nests (Fig. 1C), while the internal cell counterpart, facing the degenerating, necrotic centre of the tumour nests, occasionally showed positive tumour cells. In an inverse manner, p27kip1 staining, when present, was specifically polarized, highlighting the cells toward the central necrosis, whereas the basal cells at the invading front of the tumour, showing peripheral nuclear palisading arrangements, were negative (Fig. 1D). p27kip1 positive staining was characteristically revealed mainly in the areas of squamous cell carcinoma (Fig. 1E).
Backward elimination of variables by stepwise procedure (at each step, removing the variable that contributes least to group discrimination) isolated the variable p27kip1 (P = 0.01). The 81,3% of subjects were correctly well classified as belonging to the group membership (Tabs 4, 5).
Although Squamous Cell Carcinoma (SCC) represents the majority of laryngeal cancers, new entities with more severe prognostic implications have been described. One of them is Basaloid Squamous Cell Carcinoma (BSCC), first reported as a clinical-pathologic entity by Wain et al in 1986 [1]. This rare tumour is a histological distinctive variant of SCC with predilection for head and neck region, generally presenting in advanced stage at diagnosis, characterized by aggressive clinical course and extremely poor prognosis.
The survival of patients with head and neck cancer has not changed in the last thirty years [40-42]. The progresses of the classical therapeutic strategies, such as irradiation and surgery, have been unsuccessful in improving the survival rate for these patients. Clinical general status, histopathology examination and tumour classification still remarkably influence the treatment plan.
Several prognostic criteria have been hypothesized to play a role in SCC outcome in the past two decades. Some of the traditional parameters (TNM classification) have been considered useful in predicting the clinical behaviour of this tumour. Nevertheless, the need of finding more reliable predictors of the biological behaviour in single case has become mandatory, with the resultant recent studies on the role of oncogenic markers in tumour onset and progression of SCC [30,44-46]
To the best of our knowledge only four studies investigating the role of oncogenic markers in laryngeal BSCC have been published [21,22,34,35]. In our study the prognostic value of Ki67/Mib-1, p53 and p27kip1 proteins immunoexpression was analyzed in 16 cases of BSCC of the larynx.
Ki67/Mib-1 is a proliferation marker highly expressed in the majority of tumours [47-49]. The Ki67/Mib-1 proliferation index, however, does not allow an unequivocal discrimination between cancers with different "biological" behaviour. Moreover, the data on the relationship between p53 and Ki67 expression, obtained in different tumour types and from different series are somehow controversial.
p53 and p27kip1 play a pivotal role in regulating the cell cycle. p53 is a nuclear phosphoprotein inhibiting cell cycle progression and inducing apoptosis, both regulated by several target genes. It ultimately functions as a tumour suppressor gene, which can induce, in response to mitogenic stimuli, an arrest of the G1-S transition. p53 mutations are extremely frequent in human cancers, and missense p53 mutations with consequent over-expression of a dysfunctional but otherwise intact protein have been described [46]. In head and neck cancer, data from literature show conflicting evidence concerning the correlation between p53 expression and the most common clinicopathological parameters [36,45,49-51]. Recently p53 expression, together with Cyclin D1 over-expression, has been associated with reduced survival in laryngeal SCC [25].
p27kip1 plays an important role in protecting cells from an exuberant proliferation, by regulating cyclin dependent kinase activity thus inhibiting the G1-S transition [52]. Its function results inactive in several human tumours, either by degradation via the SCF-type E3 ubiquitin ligase, Skp2 [53] or by sequestration through Cyclin D3 [54]. In the head and neck cancer, p27kip1 expression has been considered as an independent prognostic factor, able to correlate low-expressing tumours with unfavourable course. Jordan et al. [55] demonstrated that p27kip1 was significantly reduced in oral dysplasia and carcinomas, while it was retained in normal epithelial controls. Interestingly, p27kip1 levels displayed a significant reduction in high grade in comparison with low grade dysplasia, suggesting that changes in p27kip1 expression may be an early event in oral carcinogenesis. In the larynx, a reduced expression of p27kip1protein correlates with progression in precancerous lesions [26] and with an aggressive biological behaviour in laryngeal SCC [30]. According to Pruneri et al [27] and Pignataro et al [33], immunohistochemical evaluation of p27kip1 expression is a significant independent predictor of prognosis in laryngeal carcinoma, as previously stated by Fan et al. [28] who found p27kip1 expression to be the most powerful prognostic factor among gender, tumour size, lymph node metastasis, stage of disease and p53 expression. Up to now, the role of p27kip1 as prognosticator has never been investigated in BSCC of the larynx.
In our series, p27kip1 immunohistochemical levels were nearly abolished in all DOD patients, and highly expressed in a large fraction of the patients with NED. p53 and Ki67 were globally highly expressed both in the patients with NED and in the DOD group, with a slightly lower expression in the former samples compared to the DOD patients. The correlation between p27kip1 expression and p53 or to Ki67/Mib-1 expression in DOD and NED patients groups was not statistically significant although there was a trend suggesting that it was inverse. The finding that both KI67 and p53 are over-expressed in a relevant fraction of our patients exhibiting poor outcome is in agreement with numerous published studies attributing to the above proteins a role as predictors of adverse prognosis in several human tumour types, including head and neck cancers. Never less, Ki67 and p53 expression were widely and abundantly retained also in patients in NED status, and were not able to discriminate, in a significant manner, between different outcomes. The result is not surprising in itself, considering the high proliferative capability and potential of aggressiveness of BSCC when compared to different histotypes.
Another interesting consideration comes out from the observation that p27kip1 expression is mainly localized in the focal areas of squamous cell carcinoma, supporting its role in cell differentiation. We did not find any association between squamous component representation and prognosis. In addition p27 expression, as well as the expression of Ki67 and p53, was exclusively evaluated in the pure basaloid areas.
The basaloid nests showed a p27kip1 positivity that, when present, was specifically polarized and located in the cells toward the central necrosis, some of which with a squamous-like appearance, whilst the cells at the invading front of the tumour, showing peripheral nuclear palisading arrangements, were negative for p27kip1 and intensely positive for p53, and Ki67/Mib-1.
To conclude, this study about cell cycle regulators involvement in BSCC of the larynx seems to confirm published data showing a direct correlation between decreased expression of p27kip1and poor prognosis in SCC of the head and neck. Multivariated analysis suggested a clinical prognostic relevance of p27kip1 low expression, which directly correlated with biological aggressiveness and consequent shortened survival. Further studies on larger series of BSCC warrant to better clarify this relationship.
The assessment of p27kip1 expression seems very useful to select patients for more aggressive therapies and to establish which cases can benefit from cell cycle inhibitor suitable drugs candidates [56] (i.e. the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 [57] and the cyclin-dependent kinase modulator UCN-01 (7-hydroxy-staurosporine) [58] or from new cancer gene therapy [59,60].
Competing interests
The author(s) declare that they have no competing interests.
Authors' contributions
GS and DDV equally conceived of the study, participated in its design, coordination and helped to draft the manuscript. SS made substantial contributions to acquisition, analysis and interpretation of data. GM helped to analyse data and has been involved in drafting the article. MM performed immunohistochemical study and contributed to analyse data. GQ helped to analyse data and performed multivariate analysis. VG contributed to revise the article. GDR participated in the design of the study and revised the article critically. LI participated in the design of the study, performed immunohistochemical study and helped to analyse data and to draft the manuscript.
All authors read and approved the final manuscript.
The authors wish to thank Mr. Armando Coppola and Dr Mario Nasti for their precious technical assistance.
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Asked by AngiDas at 9:31 AM on Sep. 8, 2011 in Parenting DebateLevel 15 (1,898 Credits)
Answer by dullscissors at 10:47 AM on Sep. 8, 2011
The pageants are not the issue the parents who live through their children are. They do this with sports, academics, music and many other things. The worst are the sports parents my son was in pop warner football last year and there were three fights between parents. Very disgusting that stuff is harmful to the kids. My son told me he didn't want to do it this year because it was too stressful dealing with the crazy parents. So sad so many make their child's activities about them.
Answer by healthykidsmom at 11:04 AM on Sep. 8, 2011
IMO, it can be both. If the child WANTS to be in the pageant, they have fun doing it & aren't being pushed..then they can be harmless. If the parents, like most on these children's beauty pageant shows, are pushing the child for their own selfish goals--then it can be harmful.
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Great idea, especially having three different styles for food/craft/gifts…
Thank you, this is a fun idea! I also always love the "brown paper packages tied up with string" but now I am definitely going to add a stamp pattern to my packages this year – so cute!
Gorgeous – thank you so much! :-)
So perfect! Thank you so much!!
these are so lovely! i'm definitely using the whisk tag for my homemade gifts/treats this your!
Simple but lovely, thank you :-)
Lovely thanks!
These are awesome!! Thanks!!
So pretty!! Thank you!
So great! Thank you very much!
I printed these and used them they look amazing:) Thank you! They can be seen here
I love that font on those cards. That bread also looked good.
definitely going to use this for my gifts, thank you and Merry Christmas!!!
:( the link is dead now, so sad.
Wish these were still available! So cute!
Oh, I wish these were available too! Any chance of reposting them?


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Theater Seating
Any recommendations/manufacturers for theater seating? Looking for medium-high end. TIA!
For a home theater? Or for a commercial place?
We used United Leather USA
Ordered through Gallery Furniture in Houston, but it is a company that makes what you want for your needs...so custom pieces. For instance, we wanted to optimize the area we had, so we had one section of our power recliners a "Texas sized" love seat...so if a kid or 2 small kids wanted to sit with the parents (when a movie gets scary) there was room. Also, with the 2 rows we had, we had the front row of seats slightly shorter than normal, and the back row a few inches higher than normal...so that the head of the person in front wouldn't be in the way (our ceiling height limited us...but being able to change the chairs fixed that issue.)
We were please with them. Not sure which web site shows the products better...Gallery Furniture or United Leather, but they are customizable. Didn't take long either. They were very customer friendly. The Gallery furniture store was a high priced sale "don't let them leave without a purchase" was what I heard being said to our salesman...which kind of annoyed me, but the company of the chairs (United Leather) was great.
Oh...the issue we had, which was resolved was...we had 4 seats per row...4 regular in the front, and 2 individual and a large love seat in the back. Because the loveseat was a little wider, the adjacent 2 seats were supposed to be narrower (so the row was the same width as the front row). They did make the love seat wider, but forgot to take 2 inches off of each chair in that row. Hope that makes sense. So then the chair row was 4 inches too wide, and was right on the edge of our platform. They sent out their guys, took the chairs back, cut them down, reupholstered them and redelivered them...all in about 10 days if I remember correctly. I was worried it would be noticeable, but I had completely forgotten about that until I started typing this message. I thought they were great to work with.