text:
LONDON (Reuters) - Doctors and patients should be given clearer guidance on how to avoid bleeding risks when using Boehringer Ingelheim's new stroke prevention pill Pradaxa, European regulators said on Friday.
The European Medicines Agency said data continued to confirm the positive benefit-risk balance of the anticoagulant medicine, despite cases of fatal bleeding, but advice on the risks should be strengthened.
Pradaxa is the first in a new class of medicines aimed at replacing the old and problematic drug warfarin. It is designed for use after hip and knee surgery and to prevent strokes in patients with atrial fibrillation, a form of irregular heartbeat common among the elderly.
Rival drugs include Xarelto, from Bayer and Johnson & Johnson, and Eliquis, from Bristol-Myers Squibb and Pfizer.
(Reporting by Ben Hirschler)
Trending On Reuters
Healthy, high-fat diet may be a pipedream
A much-hyped new study, conducted with just 150 participants, calls for us to "embrace fat" — even the saturated kind. The alleged benefits? Weight loss and, most incredibly, healthier hearts. But the truth is the jury is still out. Commentary


text:
New Ireland crews will compete in italy
- Other Sports
- April 4, 2014, 01:00
After the rain and winds comes a storm of activity. The Ireland team to compete in Piediluco in Italy next we(...)
Big Boats line up for Liffey challenge
- Other Sports
- March 21, 2014, 01:00
For the second consecutive weekend, Dubliners will get a chance to see big boats race down the Liffey. The Dublin Head of the River t(...)
Rowing: First head of disrupted season set for Cork
- Other Sports
- March 6, 2014, 01:00
Cork Head of the River will proceed tomorrow. The restaged time trial event on the marina in Cork is set to becom(...)
Richard Coakley chosen to represent Australia in World Cup
- Other Sports
- February 28, 2014, 01:00
Erne Head of the River will tomorrow become the first domestic event of the year to beat the weather. The organis(...)
McKeown signs up for second indoor test
- Other Sports
- November 29, 2013, 01:00
Sam McKeown, who topped the rankings of on-the-water rowers at the Irish Indoor Championships last weekend, is set to be back on the ergometer tomorro(...)
Record trend continues for Castleconnell head
- Other Sports
- November 1, 2013, 01:00
The trend of record entries for rowing events continues. Tomorrow's Castleconnell head of the river has drawn an entry of 403 crews which will race fr(...)
Espersen pleased by enthusiastic response to early first Ireland trial
- Other Sports
- September 27, 2013, 01:00
If you build it – they will come. Ireland's high performance director Morten Espersen set the first Ireland trial of the 2014 season for this weekend(...)

subset: commoncrawl


text:
UPDATE: Kyrgyzstan: Tolekan Ismailova Released from Detention
Women's Learning Partnership is pleased to share that Tolekan Ismailova was released after a local tribunal found she had not violated laws of public assembly.
However, WLP's partners at Human Rights Center "Citizens Against Corruption" have said that the court also issued a warning against disobedience of public authorities, a sign that harassment of human rights defenders in Kyrgyzstan is likely to continue.
UPDATE on: www.wluml.org/english/newsfulltxt.shtml?cmd[157]=x-157-563990
WLP urges authorities to take stronger measures to preserve the right to peaceful assembly, and to ensure the security of Ms. Ismailova and her colleagues.
Submitted on Mon, 03/23/2009 - 00:00
Related News
- Egypt: Press Release by the Special Rapporteur on Human Rights Defenders on the Appeal Verdict in the Case of Yara Sallam and Sanaa Seif
- Prominent Women Human Rights Defender Esraa Abdel-Fattah Banned From Traveling Outside Egypt
- Bangladesh: Government plans to relocate camps cause fear and anxiety among Rohingya refugees from Myanmar.
- North Africa: Racism, sexism and violence against sub-Saharan African migrant women
- Losing Hope in Iran and Egypt
Related Actions
- Egypt: Judicial harassment of Ms. Azza Soliman
- Please acquit and release Asia Bibi
- Over 220 Global Organizations Call for Immediate Release of Seven Imprisoned Women Human Rights Defenders in Egypt
- Send your support to Yara Sallam and other human rights defenders imprisoned in Egypt
- URGENT: Join the international campaign against Egypt's repressive protest law!
Relevant Resources
- Egypt: #noprotestlaw campaign abridged toolkit
- No One is Safe: Abuses of Women in Iraq's Criminal Justice System
- Everyone's Guide to By-passing Internet Censorship
- WSF: Two cheers for multiculturalism
- WSF: The rise of fundamentalism and the role of the 'state' in the specific political context of Palestine


text:
Timeless Hostel boasts comfortable dormitory rooms and private guest rooms, a patio that offers a view of Lijiang Old... Plus d'info »
Overlooking the river and offering western breakfasts homemade by our American cook, this guesthouse's relaxed... Plus d'info »
亲爱的朋友,欢迎你们来到丽江,不论你来自哪里,我们今天的相逢都是老天赐予的美好而神奇的缘分;欢迎你来到我的尘点客栈,希望一杯香茶能消除你旅途奔波的劳顿,丽江的花海和我们的热情也能为你的旅途增添一点快乐的回忆;我是个单纯的北京女孩,请不... Plus d'info »
Warmly welcome to Panba Lakeside Lodge! I am Ben-a backpacker from Taiwan. I love traveling very much, and I have... Plus d'info »
Despite what you might read, Mama's is in the old town of Lijiang. Great meals, actually, really amazing,beds were... Plus d'info »
Reminder: Dear Guest(s), if you book \'\'Superior Double Bed Private \'\' (with shower & Western toilet) you will be... Plus d'info »
International Youth Hostel Lijiang, is the first ever Youth Hostel in Lijiang, opened in 2000. The most convenient... Plus d'info »
Latest Activities: (1) The 2014 COART Festival will be held in Shuhe ancient Town on 23rd April, our Guesthouse will... Plus d'info »
Indigo Pure Inn is located on the hillside of Xiang Shan Mountain, where lives many local Na Xi People and some... Plus d'info »
Lu House Located in the historic Shuhe Old Town, it is a 10-minute walk from the popular site Sifang Street. It... Plus d'info »
We have eight room types ,12-bed room , 8-bed room , 6-bed room, 4-bed room,Deluxe 4-bed suite,single room,Tatami... Plus d'info »
Lao Shay Youth Hostel Lijiang is in the old town 10 years. Recommended by Lonely Planet for many years, is famous... Plus d'info »
Hai Rong Hotel feature 46 rooms of different type, all of which equipped with separate bathroom, cable TV, AC,... Plus d'info »
Wenlin27 Guesthouse is located in a quiet area, near Ganze Spring which is the biggest Three-eye well in Lijiang old... Plus d'info »
Welcome to October Inn of Lijiang, Yunnan province. October Inn is an international hostel in a quiet area on the... Plus d'info »
Yuan Qi Hotel is built in October 2014, on Shuhe old town, 15-minute walk from the popular site Sifang Street.... Plus d'info »
Located in Lijiang Old Town, E-Outfitting Moon Hostel is near Bar Street and Square Street. Due to the great... Plus d'info »
"WONA" International Youth Hostel is located at the lake shore of Lashi Lake, which is 10 km. outside Lijiang,... Plus d'info »
701 Express Hotel(Lijiang Branch) is based on local characteristics of YunNan and multi-ethnic culture and created an... Plus d'info »
Desti Youth Park is located in Shuhe ancient town, Lijiang, Yunnan province, China(close to COART VILLAGE),composed... Plus d'info »


text:
'Touch' Enlists '24's' Mykelti Williamson, 'Titanic's' Frances Fisher (Exclusive)
They'll recur on the upcoming second season of Fox's Kiefer Sutherland drama.
Fox's Touch is welcoming another 24 alum and a Titanic survivor to its ranks.
The Kiefer Sutherland starrer has tapped Mykelti Williamson and Frances Fisher for recurring roles on its upcoming second season, The Hollywood Reporter has learned exclusively.
PHOTOS: Broadcast TV's Returning Shows 2012-13
Williamson, who played Brian Hastings on 24, will portray LAPD Detective Lang, who's described as having seen it all and possessing a keen sense for the truth. His credits also include Justified and Forrest Gump.
Fisher, who played Kate Winslet's snobby mother in Titanic, will play Nicole Farington, the ultra-competent head of Aster Corps. Her credits include Unforgiven, House of Sand and Fog and The Shield.
STORY: 'Touch' Adds 'Lost' Alum as Series Regular, Pair of Recurring Characters for Season 2
Touch, which returns to the Fox schedule on Friday, Feb. 1 at 9 p.m., has added a roster of new faces for season two, including Lukas Haas, Saxon Sharbino, Greg Ellis, Said Taghmaoui, Adam Campbell and Ray Santiago, among others.
Williamson is repped by Innovative; Fisher is with Greene & Associates and Sanders Armstrong.
Email: firstname.lastname@example.com; Twitter: @Snoodit
Must Reads
Comedy Central's President on Why Trevor Noah Was Chosen as the Next 'Daily Show' Host (Q&A)
Bombshell Scientology Film Revealed: Alex Gibney on Cruise, Travolta and 'the Prison of Belief'
L.A.'s Soho House Turns 5: Membership Rejections, Success Secrets Revealed in Oral History
Gavin Polone on TV's Dirty Secret: Your Agent Gets Money for Nothing (Guest Column)
'Game of Thrones' Star Emilia Clarke on Playing Sarah Connor, Turning Down 'Fifty Shades' and Moving on From Nudity
Reality Power: The Declining Clout of the Broadcast Unscripted Chief
Why More 'Star Wars' Actors Haven't Become Stars
From Christian Bale to Benedict Cumberbatch: Why British Actors Nab So Many American Roles
The Uncensored, Epic, Never-Told Story Behind 'Mad Men'
What's Hot in TV
'Game of Thrones' Star Emilia Clarke on Playing Sarah Connor, Turning Down 'Fifty Shades' and Moving on From Nudity
NBC News Chief Andrew Lack Targets MSNBC as Priorities Emerge
Taraji P. Henson Apologizes to Glendale Police for Racial Profile Allegations
Fox Sues to Keep 'Empire' as Title of Hit Series (Exclusive)
Craig T. Nelson to Star in 'Coach' Follow-Up Series for NBC


text:
FHA Mortgage Rates The FHA does not set loan rates, because they don't loan money. The FHA purchases loans from commercial lenders that meet FHA standards. Those standards include the acceptability of the buyer, the appraisal of the property and certain properties of the loan's financial structure. That is as close as they come to setting rates. An FHA loan has a very low down payment requirement of 3%. They expect fixed rate loans to have rates based on the current market and the borrower's credit rating – as would any commercial lender. The fact that your loan will be FHA approved and insured may result in a slight reduction in interest rates. FHA loans also have insurance costs to the lender, as do all mortgages with a down payment of less than 20%. In the case of the FHA, however, those insurance payments are made to the agency instead of a commercial insurance broker. On an FHA loan the borrower will be charged an insurance premium of 1.5% of the mortgage amount and the yearly payments thereafter will be half a percent of the mortgage value. FHA also allows the financing of closing costs. Your mortgage loan will include the closing costs and will be folded into the monthly payments and amortized over thirty years. They also have limits on some of those closing costs: the fee for credit reports must be the actual cost; so too with legal fees; inspection fees are limited to $200 and the loan origination fee can be a maximum of 1% of the loan amount. For adjustable rate mortgages, the only index acceptable to the FHA is the one year Treasury bill interest rate. Annual increases are capped at 1% and the maximum interest rate can be no more than 5% of the original interest rate. There are also "hybrid" mortgages that have initial low interest periods of 3; 5; 7; or 10 years before the rated adjust. In those situations, the loan with the 3 year initial period has the same restrictions as the one year ARM described above. In the case of the 5,7 and 10 year ARMs the yearly maximum increase is 2% and the interest rate cap is 6% over the original rate.
Pages to are hidden for
"FHA Mortgage Rates"Please download to view full document


text:
Loading stream...
Now Playing
Connect with Us
Podcasts & RSS Feeds
|All Content
|View all podcasts & RSS feeds
Meet Our Hosts
Music Director, Host
Senior Producer/News and Public Service
Music Host
7:23 am
Wed October 3, 2012
Michelle Obama Wins Cookie Recipe Contest
By editor
Originally published on Wed October 3, 2012 10:14 am
Good morning. I'm Renee Montagne. Michelle Obama can celebrate a win today, now that her white and dark chocolate-chip cookies beat out Ann Romney's M&M cookies in Family Circle Magazine's Presidential Bake-Off. During the 2008 election, Cindy McCain's oatmeal butterscotch cookies won. Michelle Obama may be savoring her victory all the more, since on this, the couple's 20th anniversary, she's had to trade date night for debate night. It's MORNING EDITION. Transcript provided by NPR, Copyright NPR.


text:
With as many health and wellness blogs as there are these days, there's no excuse for ditching your regular morning smoothie for a fatty breakfast sandwich or processed protein bar. If you're broke, a few staples from the produce section will make-do for around the same cost as a drive-thru …Read More
When your go-to smoothie starts to taste boring and bland, it might be time for a spicy kick. Hot peppers might not be a typical ingredient in your green drinks, but considering they act as an anti-inflammatory, anti-fungal, anti-bacterial, and anti-allergen, they're more than deserving of a closer look. Top off …Read More
Many people tend to have a lot of problems when it comes to hair growth. In many situations, when your hair stops growing it is a strong indication that you're eating too much protein which can clog up your fine capillaries and prevent nutrients from getting to the hair follicles. …Read More
If office life has you counting down the days until summer, daydream your way to the beach with this tropical adult-beverage-turned-green-drink. The recipe, as featured on gimmesomeoven.com, puts a unique spin on an otherwise boring spinach smoothie, and is so easy you might end up making a bigger batch to …Read More
With recipes for over 120 green juice drinks and blends, the book "Raw Energy in a Glass" provides much needed nutritional guidance to bring your diet up to healthy levels. Award winning and world recognized author Stephanie Tousles gives you all the recipes you need for a variety of green …Read More
When it comes to your daily green energy drink, sometimes you simply lack the time and, well, energy to prep and blend every morning. But is it okay to make them ahead of time? Between the not-so-basics of raw, organic greens and specifics such as the absorption of vitamins and …Read More
If you're in the market for some new literature on the green drink lifestyle, we're here to help you out. Take a look at this newly published book called "The Best Green Smoothies on the Planet: The 150 Most Delicious, Most Nutritious, 100% Vegan Recipes for the World's Healthiest Drink". …Read More
There's a good reason why the green drink is touted throughout media as a miracle worker. These concoctions provide so many wonderful benefits and do so much good for every cell in the body, it's becoming clearer all the time that this isn't just a flash-in-the-pan fad bound to go the way …Read More
If you're considering having a baby, the best time to get your body fit, healthy and ready for pregnancy is now. For nine long months, a growing fetus depends on her mother to provide the proper nutrients, vitamins and minerals that will ensure the healthiest possible outcome for both mother and …Read More
A green energy drink or green smoothie, is a great way to use up that produce you purchased and promised yourself you would eat. Many people go to the grocery store with the best intentions. They buy lots of fresh produce and plan on incorporating into their meals for the …Read More


text:
Hotel-Restaurant Sant Antoni
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Free High-Speed Internet
- Restaurant
Travelers also recommend:
TripAdvisor Reviews Hotel-Restaurant Sant Antoni Ribes de Freser
Travel Blogs from Ribes de Freser
La Roca
... sim, which is now all organised. We also went grocery shopping, which is quite similar to everywhere else. Yesterday was relaxed. We went to the children's padel tennis training, where we had a coffee with the parents and chatted. This was a good time to really talk to the parents. We talked about everything. I looked after Clara in the night, while Andreu went to a party. Clara is really talented, she speaks three languages ...
Back in Prades
... we parked at the fort in Collioure. Also possible to stay at the fort gratuit when other motorhomers are there. We also noticed a road ascending towards a high hill with a tower on it so another venture for next time. Enjoying the sight of snow on the top of Canigou and the clear air but very windy this ...
... too! Having planned to head into Spain we rose early, found a wifi sport and then took the auto pista past Barcelona down to L'Ametlla and arrived early, claimed our favourite pitch and have been sat put in the sun since 1500 hours today. Still say put but now dark- we did not forget to change the clock either. En route of course we enjoyed, and I mean enjoyed, a cafe con leche, I suspect the Spanish make the best coffee in the ...
One more night
We decided on one more night at Caranca Gorge as it is so peaceful. Enjoyed salmon on the BBQ, Veuve Clicquot champagne with a light salad starter and lovely local walnuts for pleasure with our evening coffee. Great to see that the Veuve Clicqout champagne is by appointment to HM Queen Elizabeth II, rather good for a French champagne!! A pleasant night too and this morning the decision, at last, to head into Spain. So, off to Collure ...
Back to Caranca Gorge
Back again (village name is Thues entre Valse) as it is always quiet there, well sheltered and of course flat so a better night's sleep. Super BBQ and then Thursday morning off to the Thermal Baths again, still brilliant and now having a cuppa cola before we make any decisions about what and where ...


text:
- Description
DetailsSpornette Fahrenheit 464 Rounder Hair Brush 3 Inch
Designed to stand up to today's keratin type treatments, the Spornette Fahrenheit 464 Rounder Hair Brush features innovative nylon bristles that are heat resistant up to 464 degrees Fahrenheit. The ceramic barrel rapidly distributes and retains that heat evenly, while boar bristles add shine and smoothness to your hair and nano-silver additives keep your hair smelling clean.
The 3-inch diameter barrel is ideal for long hair.
Buy Spornette brushes, including our Fahrenheit 464 series and more, at BigDaddyBeauty.com today!
Manufacturer: SpornetteSKU: SPOR-464-10Weight: 0.3 lbs100% Guaranteed Authentic
- Additional Information
Additional Information
Ingredients N/A Ingredients
- Reviews
You may also be interested in the following product(s)
Spornette Nylon Tipped Wooden Paddle Cushion Hair Brush #5161$12.00 As low as: $10.50
Spornette Nylon Tipped Pink Paddle Hair Brush #5200$20.00 As low as: $18.00
Spornette Hypnotique Paddle Brush Silver 5901$27.00 As low as: $24.90
Spornette Hypnotique Paddle Brush Purple 5902$27.00 As low as: $24.90


text:
A man accused of pulling the beard of a Sikh professor in an attack where young men called the professor "Osama" and a "terrorist" has been arrested and charged with a hate crime, police in New York City said on Saturday.
Christian Morales (20) was charged with aggravated harassment in connection with September's attack on Columbia University professor Prabhjot Singh, who suffered a broken jaw.
Mr. Singh (31) was walking home with a friend when he was approached by a group of 12 to 15 young men, he said days after his attack.
"I heard, 'Get him. Osama.' I heard 'terrorist.' And I felt somebody grab my beard," Mr. Singh said.
Mr. Singh did not return a message seeking comment on Saturday.
Morales was in custody and unavailable for comment. It was unclear if he had an attorney.
Detectives from the hate crimes task force are investigating the case.
Mr. Singh co-authored a 2012 op-ed in The New York Times accusing the federal government of failing to accurately measure the extent of anti-Sikh violence in response to the August 2012 shooting at a Sikh temple in Milwaukee that left six people and the white supremacist gunman dead.
In the op-ed, Mr. Singh and his co-author argued that it is wrong "to assume that every attack against a Sikh is really meant for a Muslim." They said Sikhs have historically been targeted.
Keywords: New York City, Prabhjot Singh, US racism, hate crimes, Sikh attacks


text:
Thanks for taking the time to report this user.
Your participation helps keep Airbnb a safe and trusted
community, and it doesn't go unnoticed!
I'm 31 from Manchester and work for Lush. I love collecting anything old and travelling to antique and vintage fairs. I enjoy going to gigs and exhibitions in my spare time, as well as reading blogs and a spot of amature photography. X
Simone has completed online and offline ID verification.
Learn more »
Simone and her partner are great AirBnB guests. She communicated very clearly before their arrival. Very friendly and appreciative of our space. Put up with our rather noisy gardening antics on Sunday morning. Left everything very clean and tidy. I'd definitely recommend them to other hosts


text:
MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model
PURPOSE: To investigate the potential of targeted MR signal amplification strategy for imaging of EGF receptor variant III (EGFRvIII) overexpression associated with the infiltrating margin of aggressive orthotopic brain tumors.
PROCEDURES: F(ab')2 fragments of humanized anti-EGFRvIII monoclonal antibody (EMD72000) were linked to deglycosylated horseradish peroxidase (HRP) and glucose oxidase (GOX). Detection of the F(ab')2 conjugate pair colocalization in vivo was enabled by a subsequent IV injection of a low molecular weight paramagnetic substrate of HRP, diTyr-GdDTPA.
RESULTS: The delivery of the targeted fragments to the tumor was validated using SPECT/CT imaging of radiolabeled anti-EGFRvIII F(ab')2 conjugates. Further, by using 3 T MRI, we observed time-dependent differences in tumor signal intensity and signal retention at the endpoint depending on whether or not the animals were pre-injected with the anti-EGFRvIII F(ab')2 conjugates.
CONCLUSIONS: Imaging of EGFRvIII expression in vivo was enabled by consecutive administration of targeted F(ab')2 conjugates and a paramagnetic substrate resulting in a tumor-specific receptor detection with high specificity and resolution.
Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles
PURPOSE: To determine and compare pharmacokinetics and toxicity of two nanoformulations of Vasoactive Intestinal Peptide (VIP).
METHODS: VIP was formulated using a micellar (Sterically Stabilized Micelles, SSM) and a polymer-based (Protected Graft Copolymer, PGC) nanocarrier at various loading percentages. VIP binding to the nanocarriers, pharmacokinetics, blood pressure, blood chemistry, and acute maximum tolerated dose (MTD) of the formulations after injection into BALB/c mice were determined.
RESULTS: Both formulations significantly extend in vivo residence time compared to unformulated VIP. Formulation toxicity is dependent on loading percentage, showing major differences between the two carrier types. Both formulations increase in vivo potency of unformulated VIP and show acute MTDs at least 140 times lower than unformulated VIP, but still at least 100 times higher than the anticipated highest human dose, 1-5 mug/kg. These nanocarriers prevented a significant drop in arterial blood pressure compared to unformulated VIP.
CONCLUSIONS: While both carriers enhance in vivo residence time compared to unformulated VIP and reduce the drop in blood pressure immediately after injection, PGC is the excipient of choice to extend residence time and improve the safety of potent therapeutic peptides such as VIP.
Dynamic monitoring of blood-brain barrier integrity using water exchange index (WEI) during mannitol and CO2 challenges in mouse brain
The integrity of the blood-brain barrier (BBB) is critical to normal brain function. Traditional techniques for the assessment of BBB disruption rely heavily on the spatiotemporal analysis of extravasating contrast agents. However, such methods based on the leakage of relatively large molecules are not suitable for the detection of subtle BBB impairment or for the performance of repeated measurements in a short time frame. Quantification of the water exchange rate constant (WER) across the BBB using strictly intravascular contrast agents could provide a much more sensitive method for the quantification of the BBB integrity. To estimate WER, we have recently devised a powerful new method using a water exchange index (WEI) biomarker and demonstrated BBB disruption in an acute stroke model. Here, we confirm that WEI is sensitive to even very subtle changes in the integrity of the BBB caused by: (i) systemic hypercapnia and (ii) low doses of a hyperosmolar solution. In addition, we have examined the sensitivity and accuracy of WEI as a biomarker of WER using computer simulation. In particular, the dependence of the WEI-WER relation on changes in vascular blood volume, T1 relaxation of cellular magnetization and transcytolemmal water exchange was explored. Simulated WEI was found to vary linearly with WER for typically encountered exchange rate constants (1-4 Hz), regardless of the blood volume. However, for very high WER ( > 5 Hz), WEI became progressively more insensitive to increasing WER. The incorporation of transcytolemmal water exchange, using a three-compartment tissue model, helped to extend the linear WEI regime to slightly higher WER, but had no significant effect for most physiologically important WERs (WER < 4 Hz). Variation in cellular T1 had no effect on WEI. Using both theoretical and experimental approaches, our study validates the utility of the WEI biomarker for the monitoring of BBB integrity.
A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo
Bis-phenylamides and bis-hydroxyindolamides of diethylenetriaminepentaacetic acid-gadolinium (DTPA(Gd)) are paramagnetic reducing substrates of peroxidases that enable molecular imaging of peroxidase activity in vivo. Specifically, gadolinium chelates of bis-5-hydroxytryptamide-DTPA (bis-5HT-DTPA(Gd)) have been used to image localized inflammation in animal models by detecting neutrophil-derived myeloperoxidase (MPO) activity at the inflammation site. However, in other preclinical disease models, bis-5HT-DTPA(Gd) presents technical challenges due to its limited solubility in vivo. Here we report a novel MPO-sensing probe obtained by replacing the reducing substrate serotonin (5-HT) with 5-hydroxytryptophan (HTrp). Characterization of the resulting probe (bis-HTrp-DTPA(Gd)) in vitro using nuclear magnetic resonance spectroscopy and enzyme kinetic analysis showed that bis-HTrp-DTPA(Gd) (1) improves solubility in water; (2) acts as a substrate for both horseradish peroxidase and MPO enzymes; (3) induces cross-linking of proteins in the presence of MPO; (4) produces oxidation products, which bind to plasma proteins; and (5) unlike bis-5HT-DTPA(Gd), does not follow first-order reaction kinetics. In vivo magnetic resonance imaging (MRI) in mice demonstrated that bis-HTrp-DTPA(Gd) was retained for up to 5 days in MPO-containing sites and cleared faster than bis-5HT-DTPA(Gd) from MPO-negative sites. Bis-HTrp-DTPA(Gd) should offer improvements for MRI of MPO-mediated inflammation in vivo, especially in high-field MRI, which requires a higher dose of contrast agent.
Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes
We designed and synthesized sensors for imaging transcription factor-DNA interactions using a complementary pair of 21-base pair long oligonucleotides (ODNs) carrying two internucleoside phosphate-linked cyanine fluorophores that can either engage in Forster's resonance energy transfer (FRET) with fluorescence emission or assemble into a ground state quenched dimer with short fluorescence lifetimes (FL). Cyanine fluorophores were linked to ODNs within the NF-kappaB binding site. These sensors were tested in the presence of recombinant p50 and p65 NF-kappaB proteins or constitutively NF-kappaB activating HeLa cell lysates. By using a coherent light excitation source we followed changes in fluorescence lifetime of the donor (Cy5.5) at the donor's excitation and emission light wavelengths, as well as the acceptor (800CW or Cy7 cyanine fluorophores) in FRET mode. We observed increases in the donor lifetime in both emitting (0.08-0.15 ns) and non-emitting quenched (0.21 ns) sensors in response to protein binding. The measurements of lifetimes in FRET mode in quenched pair-carrying ODN duplex sensors showed significant differences in FL of the acceptor cyanine fluorophore between NF-kappaB-containing and NF-kappaB-free samples but not in control sensors with ODN sequences that have decreased binding affinity to NF-kappaB. We anticipate that the observed effects will be instrumental for developing sensors enabling non-invasive imaging in cells that undergo activation of NF-kappaB.
In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium
Activatable fluorescent molecular probes are predominantly nonfluorescent in their inactivated state due to intramolecular quenching, but increase fluorescence yield significantly after enzyme-mediated hydrolysis of peptides. Continuous wave in vivo detection of these protease-activatable fluorophores in the heart, however, is limited by the inability to differentiate between activated and nonactivated fractions of the probe and is frequently complicated by large background signal from probe accumulation in the liver. Using a cathepsin-activatable near-infrared probe (PGC-800), we demonstrate here that fluorescence lifetime (FL) significantly increases in infarcted murine myocardial tissue (0.67 ns) when compared with healthy myocardium (0.59 ns) after 24 h. Furthermore, we show that lifetime contrast can be used to distinguish in vivo cardiac fluorescence from background nonspecific liver signal. The results of this study show that lifetime contrast is a helpful addition to preclinical imaging of activatable fluorophores in the myocardium by reporting molecular activity in vivo due to changes in intramolecular quenching. This characterization of FL from activatable molecular probes will be helpful for advancing in vivo imaging of enzyme activity.
Orthotopic expression of noggin protein in cancer cells inhibits human lung carcinoma growth in vivo
PURPOSE: We explored the effect of Noggin protein expression on tumor growth in vivo by using fluorescence imaging.
PROCEDURES: Human lung carcinoma MV522 cells were transduced by using bicistronic (EGFP/Nog) or a control (EGFP) lentivirus at > 95% efficacy. The transduced cells were implanted in athymic mice either individually or after mixing with DsRed2-expressing MV522 cells.
RESULTS: The expression of Noggin protein was demonstrated in EGFP+/Nog+ but not in EGFP+ cell lysates and conditioned media. Noggin did not inhibit tumor cell proliferation in vitro. Implantation of EGFP+ resulted in rapid tumor growth, whereas mice implanted with EGFP+/Nog+ either failed to develop tumors or developed smaller slowly proliferating ones. In the case of tumors grown from mixtures with DsRed2+ cells, only Noggin-expressing cells resulted in decreased tumor volumes with low vascular density and poorly developed stroma.
CONCLUSION: The effect of Noggin protein expression is a consequence of inhibition of stromal and/or endothelial proliferation in vivo.
Protected graft copolymer (PGC) basal formulation of insulin as potentially safer alternative to Lantus(R) (insulin-glargine): a streptozotocin-induced, diabetic Sprague Dawley rats study
PURPOSE: To develop a long-acting formulation of native human insulin with a similar pharmacodynamics (PD) profile as the insulin analogue insulin glargine (Lantus(R), Sanofi-Aventis) with the expectation of retaining native human insulin's superior safety profile as insulin glargine is able to activate the insulin-like growth factor 1 (IGF-1) receptor and is linked to a number of malignancies at a higher rate than regular human insulin.
METHODS: Development of protected graft copolymer (PGC) excipients that bind native human insulin non-covalently and testing blood glucose control obtained with these formulations in streptozotocin-induced diabetic Sprague Dawley rats compared to equally dosed insulin glargine.
RESULTS: PGC-formulations of native human insulin are able to control blood glucose to the same extent and for the same amount of time after s.c. injection as the insulin analogue insulin glargine. No biochemical changes were made to the insulin that would change receptor binding and activation with their possible negative effects on the safety of the insulin.
CONCLUSION: Formulation with the PGC excipient offers a viable alternative to biochemically changing insulin or other receptor binding peptides to improve PD properties.
Imaging the pancreatic vasculature in diabetes models
BACKGROUND: Vascular parameters, such as vascular volume, flow, and permeability, are important disease biomarkers for both type 1 and type 2 diabetes. Therefore, it is essential to develop approaches to monitor the changes in pancreatic microvasculature non-invasively.
METHODS: Here, we describe the application of the long-circulating, paramagnetic T1 contrast agent, protected Graft Copolymer bearing covalently linked gadolinium diethylenetriaminepentaacetic acid residues and labelled with fluorescein (PGC-GdDTPA-F) for the non-invasive semi-quantitative evaluation of vascular changes in diabetic models using magnetic resonance imaging.
RESULTS: We observed a significantly higher accumulation of protected graft copolymer bearing covalently linked gadolinium diethylenetriaminepentaacetic acid residues and labelled with fluorescein in the pancreata of BBDR rats induced to develop diabetes, as compared to non-diabetic controls at 1 h post-injection. No differences were seen in the blood pool, kidney, or muscle, indicating that the effect is specific to the diabetic pancreas. Fluorescence microscopy revealed a marked increase in contrast agent availability in the pancreas with the development of the pathology. Similar changes were noted in the homozygous Leprdb mouse model of type 2 diabetes. This effect appeared to result both from the increase of vascular volume and permeability.
CONCLUSIONS: High-molecular weight paramagnetic blood volume contrast agents are valuable for the in vivo definition of pancreatic microvasculature dynamics by magnetic resonance imaging. The increase in vascular volume and permeability, associated with diabetic inflammation, can be monitored non-invasively and semi-quantitatively by magnetic resonance imaging in diabetic BBDR rats. This imaging strategy represents a valuable research tool for better understanding of the pathologic process.
Hairpin-like fluorescent probe for imaging of NF-kappaB transcription factor activity
Three oligodeoxyribonucleotides (ODN) covalently labeled with near-infrared (NIR) fluorochromes were synthesized and characterized with a goal of comparing in vitro a hairpin-based and a duplex-based FRET probe designed for the detection of human recombinant NF-kappaB p50/p65 heterodimer binding to DNA. Using deoxyguanosine phosphoramidite with a phosphorus-linked aminoethylene (diethylene glycol) hydrophilic linker, we synthesized ODNs with internucleoside reactive sites. The hairpin loop amino linker was modified with IRDye 800CW (FRET acceptor), and the 3'-end was modified with Cy5.5 (FRET donor) using a dithio-linker. To obtain a duplex probe, we conjugated Cy5.5 and 800CW to complementary strands at the distance of ten base pairs in the resultant duplex. No quenching of dyes was observed in either probe. The FRET efficiency was higher in the duplex (71%) than in the hairpin (56%) due to a more favorable distance between the donor and the acceptor. However, the hairpin design allowed more precise ratiometric measurement of fluorescence intensity changes as a result of NF-kappaB p50/p65 binding to the probe. We determined that as a result of binding there was a statistically significant increase of fluorescence intensity of Cy5.5 (donor) due to a decrease of FRET if normalized by 800CW intensity measured independently of FRET. We conclude that the hairpin based probe design allows for the synthesis of a dual fluorescence imaging probe that renders signal changes that are simple to interpret and stoichiometrically correct for detecting transcription factor-DNA interactions.
In vitro and In vivo imaging of antivasculogenesis induced by Noggin protein expression in human venous endothelial cells
Noggin protein is a potent bone morphogenetic protein (BMP) antagonist capable of inhibiting vasculogenesis even in the presence of provasculogenic VEGF and FGF-2. We found that human umbilical vein endothelial cells (HUVECs) do not express Noggin in culture and used these cells for modeling of antivasculogenesis. We hypothesized that high-efficiency transduction of HUVECs with bicistronic lentiviral vector encoding Noggin and enhanced green fluorescent protein (EGFP) enables direct visualization of Noggin effects in homogenous primary cell populations in vitro and in vivo. By comparing HUVECs transduced with a control GFP and GFP/Noggin expression cassettes, we showed that constitutive and orthotopic Noggin protein expression did not influence cell proliferation, down-regulated BMP-2 expression, and showed no effect on BMP receptor transcripts. We demonstrated that in contrast to GFP-only control, Noggin expression in endothelial cells abrogated endothelial migration in response to monolayer injury, blocked endothelial transmigration, and caused abrogation of cord formation in vitro. Adding exogenous BMP-4 restored the formation of cords. Imaging experiments in vivo investigated vessel formation in Matrigel implants in athymic mice by utilizing GFP imaging or magnetic resonance imaging of perfusion in the implants. Both approaches demonstrated the lack of functional vessel formation after the adoptive transfer of GFP/Noggin-expressing human endothelial cells in mice.
Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques
BACKGROUND: Inflammation undermines the stability of atherosclerotic plaques, rendering them susceptible to acute rupture, the cataclysmic event that underlies clinical expression of this disease. Myeloperoxidase is a central inflammatory enzyme secreted by activated macrophages and is involved in multiple stages of plaque destabilization and patient outcome. We report here that a unique functional in vivo magnetic resonance agent can visualize myeloperoxidase activity in atherosclerotic plaques in a rabbit model.
METHODS AND RESULTS: We performed magnetic resonance imaging of the thoracic aorta of New Zealand White rabbits fed a cholesterol (n=14) or normal (n=4) diet up to 2 hours after injection of the myeloperoxidase sensor bis-5HT-DTPA(Gd) [MPO(Gd)], the conventional agent DTPA(Gd), or an MPO(Gd) analog, bis-tyr-DTPA(Gd), as controls. Delayed MPO(Gd) images (2 hours after injection) showed focal areas of increased contrast ( > 2-fold) in diseased wall but not in normal wall (P=0.84) compared with both DTPA(Gd) (n=11; P < 0.001) and bis-tyr-DTPA(Gd) (n=3; P < 0.05). Biochemical assays confirmed that diseased wall possessed 3-fold elevated myeloperoxidase activity compared with normal wall (P < 0.01). Areas detected by MPO(Gd) imaging colocalized and correlated with myeloperoxidase-rich areas infiltrated by macrophages on histopathological evaluations (r=0.91, P < 0.0001). Although macrophages were the main source of myeloperoxidase, not all macrophages secreted myeloperoxidase, which suggests that distinct subpopulations contribute differently to atherogenesis and supports our functional approach.
CONCLUSIONS: The present study represents a unique approach in the detection of inflammation in atherosclerotic plaques by examining macrophage function and the activity of an effector enzyme to noninvasively provide both anatomic and functional information in vivo.
Plate capture assay of fluorescent oligonucleotide duplex reporter-transcription factor complexes
We previously developed prototype oligodeoxyribonucleotide (ODN) duplex fluorescence energy transfer (FRET) reporters for optical sensing of NF-kappaB transcription factor. We report here a plate-binding assay designed for optimizing the above reporters. Nitrilotriacetate-bearing plates were prepared by using sequential (1) aminosilylation; (2) carboxylation; (3) coupling of Nalpha,Nalpha-bis(carboxymethyl)-L-lysine or, alternatively, by replacing steps 1 and 2 by treating the glass with 3-(triethoxysilyl)propylsuccinic anhydride. FRET reporters were obtained by covalent linking of Cy5.5 (fluorescence donor) and IRdye800CW (fluorescence acceptor) to complementary ODN strands encoding a high-affinity p50 binding site. Recombinant 6 x His tagged NF-kappaB p50 was used for immobilizing the protein on glass plates via linked NTA-Ni(II) groups. Imaging and quantification of the fluorescence intensity in the wells was performed in two channels (700 and 800 nm) using a near-infrared scanning device with microscopic resolution. The fluorescence intensity of the ODN duplex reporter was detectible in the plates at the concentration of 5 pM. NF-kappaB p50-ODN reporter interaction was studied by measuring the ratio of 700 nm (donor) to 800 nm (acceptor) fluorescence intensities. Using the plate assay, we were able to measure p50-mediated interference with FRET at low density of plate binding.
Large-angle x-ray scatter in Talbot-Lau interferometry for breast imaging
Monte Carlo simulations were used to investigate large-angle x-ray scatter at design energy of 25 keV during small field of view (9.6 cm x 5 cm) differential phase contrast imaging of the breast using Talbot-Lau interferometry. Homogenous, adipose and fibroglandular breasts of uniform thickness ranging from 2 to 8 cm encompassing the field of view were modeled. Theoretically determined transmission efficiencies of the gratings were used to validate the Monte Carlo simulations, followed by simulations to determine the x-ray scatter reaching the detector. The recorded x-ray scatter was classified into x-ray photons that underwent at least one Compton interaction (incoherent scatter) and Rayleigh interaction alone (coherent scatter) for further analysis. Monte Carlo based estimates of transmission efficiencies showed good correspondence [Formula: see text] with theoretical estimates. Scatter-to-primary ratio increased with increasing breast thickness, ranging from 0.11 to 0.22 for 2-8 cm thick adipose breasts and from 0.12 to 0.28 for 2-8 cm thick fibroglandular breasts. The analyzer grating reduced incoherent scatter by ~18% for 2 cm thick adipose breast and by ~35% for 8 cm thick fibroglandular breast. Coherent scatter was the dominant contributor to the total scatter. Coherent-to-incoherent scatter ratio ranged from 2.2 to 3.1 for 2-8 cm thick adipose breasts and from 2.7 to 3.4 for 2-8 cm thick fibroglandular breasts.
Computerized 3-dimensional localization of a video capsule in the abdominal cavity: validation by digital radiography
BACKGROUND: Wireless video capsule endoscopy allows the noninvasive visualization of the small intestine. Currently, capsules do not provide localization information while traversing the GI tract.
OBJECTIVE: To report on the radiological validation of 3-dimensional localization software incorporated in a newly developed capsule. By using radiofrequency transmission, the software measures the strength of the capsule's signal to locate the position of the capsule.
SETTING: This study was performed at the University of Massachusetts Medical Center, Worcester, Mass.
PATIENTS: Thirty healthy volunteers consented to the experimental procedure.
DESIGN: After ingestion of the capsule, subjects had 5 sets of anteroposterior and lateral radiographs taken every 30 minutes while the software calculated the position of the capsule. By using the radiographs, we calculated the location of the capsule in the abdominal cavity and compared the results with those generated by the software.
RESULTS: Average error (and standard deviation) among the 3-dimensional coordinates was X, 2.00 cm (1.64); Y, 2.64 cm (2.39); and Z, 2.51 cm (1.83). The average total spatial error among all measurements was 13.26 cm(3) (22.72). There was a correlation between increased subject body mass index and the 3-dimensional software measurement error.
LIMITATIONS: This study was performed in healthy volunteers and needs further validation in patients with small intestinal disorders.
CONCLUSIONS: The new 3-dimensional software provides localization of the capsule consistent with radiological observations. However, further validation of the software's clinical utility is required with a prospective clinical trial. Mosby, Inc. All rights reserved.
Assessment of liver fat in an obese patient population using noncontrast CT fat percent index
OBJECTIVE: To develop a simplified method to quantify liver fat using computed tomography (CT) fat % index (CTFPI) compared to liver spleen method (CTL/S, CTL-S).
METHODS: Noncontrast CT of the liver was performed in 89 patients (overweight, obese, severely obese) to quantify fat, using the following: CTFPI = [(65-patient HU)/65]x100, normal live r = 65 HU.
RESULTS: There was a strong linear correlation between CTFPI and the standard method of assessing liver fat using CTL/S (r = -0.901), CTL-S (r = -0.911). Hepatic HU and CTFPI were significantly different in the severely obese group compared to other two groups (P < .05).
CONCLUSION: Significant correlation indicates equal diagnostic accuracy of the two methods in appropriately calibrated scanners.
The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples
Mammography is the gold standard in routine screening for the detection of breast cancer in the general population. However, limitations in sensitivity, particularly in dense breasts, has motivated the development of alternative imaging techniques such as digital breast tomosynthesis, whole breast ultrasound, breast-specific gamma imaging, and more recently dedicated breast computed tomography or "breast CT". Virtually all diagnostic work-ups of asymptomatic nonpalpable findings arise from screening mammography. In most cases, diagnostic mammography and ultrasound are sufficient for diagnosis, with magnetic resonance imaging (MRI) playing an occasional role. Digital breast tomosynthesis, a limited-angle tomographic technique, is increasingly being used for screening. Dedicated breast CT has full three-dimensional (3D) capability with near-isotropic resolution, which could potentially improve diagnostic accuracy. In current dedicated breast CT clinical prototypes, 300-500 low-dose projections are acquired in a circular trajectory around the breast using a flat panel detector, followed by image reconstruction to provide the 3D breast volume. The average glandular dose to the breast from breast CT can range from as little as a two-view screening mammogram to approximately that of a diagnostic mammography examination. Breast CT displays 3D images of the internal structures of the breast; therefore, evaluation of suspicious features like microcalcifications, masses, and asymmetries can be made in multiple anatomical planes from a single scan. The potential role of breast CT for diagnostic imaging is illustrated here through clinical examples such as imaging soft tissue abnormalities and microcalcifications. The potential for breast CT to serve as an imaging tool for extent of disease evaluation and for monitoring neo-adjuvant chemotherapy response is also illustrated.
Personalized estimates of radiation dose from dedicated breast CT in a diagnostic population and comparison with diagnostic mammography
This study retrospectively analyzed the mean glandular dose (MGD) to 133 breasts from 132 subjects, all women, who participated in a clinical trial evaluating dedicated breast CT in a diagnostic population. The clinical trial was conducted in adherence to a protocol approved by institutional review boards and the study participants provided written informed consent. Individual estimates of MGD to each breast from dedicated breast CT was obtained by combining x-ray beam characteristics with estimates of breast dimensions and fibroglandular fraction from volumetric breast CT images, and using normalized glandular dose coefficients. For each study participant and for the breast corresponding to that imaged with breast CT, an estimate of the MGD from diagnostic mammography (including supplemental views) was obtained from the DICOM image headers for comparison. This estimate uses normalized glandular dose coefficients corresponding to a breast with 50% fibroglandular weight fraction. The median fibroglandular weight fraction for the study cohort determined from volumetric breast CT images was 15%. Hence, the MGD from diagnostic mammography was corrected to be representative of the study cohort. Individualized estimates of MGD from breast CT ranged from 5.7 to 27.8 mGy. Corresponding to the breasts imaged with breast CT, the MGD from diagnostic mammography ranged from 2.6 to 31.6 mGy. The mean (+/- inter-breast SD) and the median MGD (mGy) from dedicated breast CT exam were 13.9 +/- 4.6 and 12.6, respectively. For the corresponding breasts, the mean (+/- inter-breast SD) and the median MGD (mGy) from diagnostic mammography were 12.4 +/- 6.3 and 11.1, respectively. Statistical analysis indicated that at the 0.05 level, the distributions of MGD from dedicated breast CT and diagnostic mammography were significantly different (Wilcoxon signed ranks test, p = 0.007). While the interquartile range and the range (maximum-minimum) of MGD from dedicated breast CT was lower than diagnostic mammography, the median MGD from dedicated breast CT was approximately 13.5% higher than that from diagnostic mammography. The MGD for breast CT is based on a 1.45 mm skin layer and that for diagnostic mammography is based on a 4 mm skin layer; thus, favoring a lower estimate for MGD from diagnostic mammography. The median MGD from dedicated breast CT corresponds to the median MGD from four to five diagnostic mammography views. In comparison, for the same 133 breasts, the mean and the median number of views per breast during diagnostic mammography were 4.53 and 4, respectively. Paired analysis showed that there was approximately equal likelihood of receiving lower MGD from either breast CT or diagnostic mammography. Future work will investigate methods to reduce and optimize radiation dose from dedicated breast CT.
Development and testing of a single frequency terahertz imaging system for breast cancer detection
The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.


text:
Skip to Main Content
IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards,
eBooks, and eLearning courses.
Learn more about:
IEEE membership
IEEE Xplore subscriptions
In recent years, there has been a tremendous amount of talk about connectivity. When the topic of connectivity comes up, what usually comes to mind is connecting to the Internet, a network, or a cloud server via some mobile wireless device or laptop. Indeed, the world seems to be going wireless. Gone are the days when the trends were all about things such as who could make the largest-screen TV. Now, there has emerged a new trend in consumer electronics (CE), and it is changing the way we interact with the world.
A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.© Copyright 2015 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


text:
Size difference? "black & blue' 'mystic spires' 'henry duelberg'
ilovemyroses(8 Dallas TX)April 2, 2013
I have read so much on this, from various sources, and am getting nowhere. Seems 'black and blue' is the tallest, more upright, the others more spreading?
Please set me straight!! How are they different in height and width, and even performance in YOUR garden.
Have several of all three waiting to be planted in a new rose bed I am expanding to include more perennials.
CA Kate
I can't comment on the Henry Duelburg, but the other two were quite different in habit in my garden. The B & B doesn't have near the volumn that the Mystic Spires does which needs a large circle around the plants with nothing under them. The crown also quickly got bigger whereas the B&B didn't.


text:
Residents of Ayanavaram have a long-pending request - to have the 3.3 km-long Ainsley Canal, which belongs to the Southern Railways, desilted and cleaned. The canal carrying untreated sewage is clogged with garbage and weeds.
P.Devi, councillor of ward 59, said: "The Ainsley Canal joins the Otteri Nullah near Podikadai bus stop on Konnur High Road. Almost every year during heavy rains when the Otteri Nullah flows to the brim, water enters homes in Subbarayan 4th and 5th streets. However, we are unable to do anything as the canal belongs to the railways," she said.
Leader of Opposition Saidai P. Ravi said that if the sewage flow in the canal was not checked, the Otteri Nullah, which was being desilted, and strengthened under the Jawaharlal Nehru National Urban Renewal Mission, would continue to carry sewage even after the completion of the project. The canal is also a breeding ground for mosquitoes. Ms. Devi said that when there are many complaints from residents about mosquitoes she requested Chennai Corporation to spray repellents in the area. Residents of Ekangipuram said as the canal is very shallow, when water in the canal raises it flows on to the road. The plastic bags are pushed onto the roads, they said.
The canal, which originates at the eastern end of Villivakkam Railway Station passes through ICF, Railway Hospital, Ayanavaram and Pananthope Colony and drains into the Otteri Nullah. K. Ramadoss, president of North Chennai Dist Exnora, said that a stench pervades the area as waste generated by poultry and animal slaughter houses is dumped into the canal. "Villivakkam MLA J.C.D. Prabhakar said that he would write to the Railways asking them to immediately desilt the canalSouthern Railway DRM S.Anantharaman said the canal was being desilted regularly. Steps would be taken to remove encroachments.
Mayor M.Subramanian said that action would be taken to take possession of the canal from the railways so that the canal can be desilted .
Keywords: Ainsley Canal, plastic bags, possession of the canal, encroachments


text:
New EIFF & Edinburgh University Course Announced
An Insight into the Edinburgh International Film Festival - Edinburgh University Open Studies Course now open for enrollment.
The University of Edinburgh offers a unique course experience, which involves the screening of six films accompanied by daily tutor-led group discussions. 'An Insight into the Edinburgh International Film Festival' will also provide four lectures, the EIFF 2012 catalogue, and access to an In Person event. Starting off with the Opening Night, the course will cover five days of programming and can be attended by anyone from the public, no previous knowledge is required. The aim is to give participants a better critical understanding of film styles, genres, and directorial approaches, set within the films' regional and national contexts.
For more detailed information and guidance on how to get enrolled, please visit the official website.
Latest news
EIFF Launches Crowdfunding Campaign to Support New Distribution Initiative
Support the Distribution Rewired campaign at http://igg.me/at/distributionrewired


text:
Local bus services in Caserta
Is there a bus service from Grand Hotel Vanvitelli, Viale Carlo III, 81025 San Marco Evangelista di Caserta Caserta, Italy, to the Royal Palace in Caserta please? And back?
Caserta to Salerno by train
I can find on the webside of trenitalia.it a direct Regional train from Caserta to Salerno avoiding to change in Napels but I try to find out how much Euros the single trip costs and which train company it runs, because I cant get any more info from trenitalia
crowne plaza caserta changed names?
has the crowne plaza at caserta been bought over by another company and had its name changed? i stayed there earlier this year and trying to book online with no success.
Suitcase in the car in the parking
On my way from Rome to Sorrento (tomorrow!!), we'll visite Caserta's Reggia' .
Is it safe to leave the suitcases in the car in the underground parking?
Is there any place in the reggia to deposite luggage (two normal suitcases)?
Thank you.
Parking for Palazzo Reale
Hi, Can someone help as where on Piazza Carlo III the Municipal car park is located.
opening hours of Caserta Gardens
good day,
someone knows if Caserta garden is open the day of the deads (toussaints)
and the day after (oct 31st and nov 1st)
thank you very much
- 1


text:
Kukla's Korner Hockey
Category: Toronto-Maple-Leafs
Grabovski vs. Kostitsyn
by Paul on 01/10/09 at 12:00 PM ET
Comments (0)
from Dave Stubbs of the Montreal Gazette,
The 24-year-old Belarus-raised native of Potsdam, East Germany, was suspended an automatic three games yesterday by the NHL for abuse of an official. Grabovski tussled with linesman Scott Cherrey in his overzealous effort to get at Canadiens' Sergei Kostitsyn.
The players never managed to dance, despite their best efforts, and both were handed misconducts for their vigorous efforts. Grabovski was given a game misconduct as a bonus.
There is bad blood between these two, litres of it. Apparently it has to do with Kostitsyn's distaste for things Grabovski is alleged to have said about himself and his brother, Andrei, to Russia's sensation-seeking sports media.
(Ask Alex Kovalev about that.) But a feud needn't be based on anything, of course, and it seems that before theirs is done, these two are bound to change their names to Hatfield and McCoy.
Filed in: NHL Teams, Montreal Canadiens, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: mikhail+grabovski, sergei+kostitsyn
Report- Grabovski Suspended Three Games
by Paul on 01/09/09 at 01:32 PM ET
Comments (0)
from Sportsnet,
Toronto Maple Leafs forward Mikhail Grabovski has been suspended for three games after shoving an offical Thursday night. Sources tell Hockeycentral the Leafs are contemplating appealing the league decision.
Grabovski received a game misconduct for shoving a linesman late in the third period of Thursday's 6-2 loss to the Montreal Canadiens at the Bell Centre.
continued and in case you missed the incident, watch here...
added 11:15am, via TSN,
The three game suspension for abuse of official is automatic, and the Maple Leafs have chosen not to appeal the ban.
Filed in: NHL Teams, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: mikhail+grabovski
An 'Official' Shove Of Push?
by Paul on 01/09/09 at 02:21 AM ET
Comments (0)
Mikhail Grabovski of the Leafs trys to get at Sergei Kostitsyn of the Canadiens. The video tells the rest of the story…
Here is the game recap from the CP via TSN.
Filed in: NHL Teams, Montreal Canadiens, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: mikhail+grabovski
The Leafs In 2011
by Paul on 01/08/09 at 08:30 PM ET
Comments (0)
from Mike Ulmer at TorontoMapleLeafs.com,
For an idea just what Burke is facing, let's take a look at the grid for opening night, 2011-2012, two and a half seasons from now.
The Leafs desperately need to get younger. To that end, I have limited the top two lines and top two defensive pairings to players 25 years or younger on opening night. Keep in mind, there will always be room for productive older players. Nik Hagman will be nearly 32, but it's hard to think his game would not be welcome somewhere on the roster.
On defence: Luke Schenn. He's a sure bet. A little below Schenn, put Jeff Finger in the depth chart. Anton Stralman has the talent to be a top four defenceman but it's impossible to accurately predict whether he will make the jump. I like Jonas Frogren's mean for the third pairing and based on his ever improving play, Ian White might be considered in the mix.
But for top four, we have one guy, Schenn.
Filed in: NHL Teams, Toronto Maple Leafs, | KK Hockey | Permalink
Leafs Don't Have Many Building Blocks
by Paul on 01/08/09 at 11:23 AM ET
Comments (0)
from Steve Simmons of the Toronto Sun,
When Paul Holmgren took over the down and out Philadelphia Flyers at least he had Mike Richards, Jeff Carter and Simon Gagne to build around.
When George McPhee began the process of starting over with the Washington Capitals, he could point to the drafting of Alexander Ovechkin as the starting point toward success.
When the Pittsburgh Penguins began to blossom, the future came primarily from the selections of Evgeni Malkin and Sidney Crosby in the drafts of 2004 and 2005.
This is Brian Burke's problem. There are no Ryan Getzlafs and Corey Perrys awaiting him as there were in Anaheim. There are no Carters, Richards, Malkins or Crosbys on the way.
Filed in: NHL Teams, Toronto Maple Leafs, | KK Hockey | Permalink
Report- Brad May To The Leafs
by Paul on 01/07/09 at 03:31 PM ET
Comments (0)
Fan590 reporting Brad May will be a Leaf. Toronto giving up a conditional pick.
added 12:36pm, Confirmed by TSN.
Filed in: NHL Teams, Anaheim Ducks, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: brad+may
Signs Of A Trade?
by Paul on 01/04/09 at 11:51 AM ET
Comments (0)
via Terry Koshan of the Toronto Sun,
Could some members of the Maple Leafs be fitted for a new jacket of the blue variety?
The Columbus Blue Jackets have had scouts shadowing several teams lately, and had two at the game Thursday night at the Air Canada Centre between the Leafs and Buffalo Sabres.
Nik Antropov and defenceman Pavel Kubina are said to interest Jackets general manager Scott Howson. And you have to figure Leafs GM Brian Burke, now just over a month on the job, is dying to make a deal. Burke apparently has told the Jackets that he gladly will move players with contracts to get draft picks in return.
Columbus also has a big interest in New York Islanders centre Doug Weight, who said last week he does not want to be a rental again.
Filed in: NHL Teams, Columbus Blue Jackets, Toronto Maple Leafs, | KK Hockey | Permalink
Leafs May Be Paving The Way For A CuJo Exit
by Paul on 12/31/08 at 11:29 AM ET
Comments (0)
from Richard Griffin of the Toronto Star,
In any case, it was a little bit of retro Leafs feeling in the building, with 19,000 fans chanting "Cu-Jo, Cu-Jo" in the second period as he withstood a barrage of Thrasher shots on back-to-back power plays, preserving a 2-2 tie. He was named the game's first star and when he skated on to the ice, the love-in started up again.
"You block out the negative stuff, but you hear the good stuff," Joseph said. "It's a great feeling. They want you to do well for sure. This is my dream job and sometimes you don't realize it till you're gone."
It's funny he should say that. Was last night the beginning of an unofficial and brief farewell tour – without the parting gifts – for the popular 41-year-old?
Think about the unusual Leafs decision to start Joseph at all in the midst of a three-game losing skid and then announce in advance that he would also start versus the Sabres. It was a head-scratcher for many.
Filed in: NHL Teams, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: curtis+joseph
Stajan Suffers Eye Injury During Soccer Warmup
by Paul on 12/28/08 at 04:37 PM ET
Comments (0)
from David Shoalts of the Globe and Mail,
Matt Stajan spent Sunday in a hospital with an eye injury and he will be lost to the Toronto Maple Leafs for at least a week as the result of a rowdy soccer game.
Stajan, the Leafs' No. 1 centre, was hit on the eye with a soccer ball before the Leafs' practice on Saturday during a warmup exercise common to NHL teams. Players gather in a circle and try to keep the ball in the air as long as possible by kicking or heading it. If a player allows the ball to hit the floor he is out of the game and the game ends when no players are left.
Filed in: NHL Teams, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: matt+stajan
Leafs Need To Be In A Position To Take Tavares
by Paul on 12/28/08 at 11:37 AM ET
Comments (0)
from Damien Cox of the Toronto Star,
It's a derby in which the Maple Leafs, not yet bad enough to get better, must have a horse.
Brian Burke knows it, Dave Nonis knows it and even Ron Wilson, you have to believe, knows it.
John Tavares' special performance on a big stage for Team Canada in the opening game of the world junior championship in Ottawa on Friday night was just the latest piece of compelling evidence that made it clear the Leafs need to be at least in a position to win the draft lottery and land the No. 1 overall pick next June.
Filed in: NHL Teams, Toronto Maple Leafs, | KK Hockey | Permalink
Tags: john+tavares
« Previous ‹ First < 148 149 150 151 152 > Last › Next »
About Kukla's Korner Hockey
Paul Kukla founded Kukla's Korner in 2005 and the site has since become the must-read site on the 'net for all the latest happenings around the NHL.
From breaking news to in-depth stories around the league, KK Hockey is updated with fresh stories all day long and will bring you the latest news as quickly as possible.
Email Paul anytime at email@example.com
Most Recent Blog Posts
KK- How To Help Kukla's Korner
The Ottawa Senators Remain In The Playoff Race
The Winnipeg Jets Still Control Their Playoff Destiny
About Those Trade Deadline Deals
Dustin Byfuglien Will Have A Hearing With The NHL Department Of Player Safety Tomorrow
NBC Sports Group Plans For The Stanley Cup Playoffs
Playoff Chances For The Winnipeg Jets Are Going South
Ken Hitchcock Still An Unsigned Coach
Video- Dustin Byfuglien's Cross-Check To The Neck Of J.T. Miller


text:
To make reservations by phone, dial freephone 0800 221 222 in the UK, 1 800 409 929 in Ireland, or view our regional telephone reservation numbers.
Fitness classes: Complimentary
Special guest privileges: Complimentary passes daily
Phone: +1-502-426-7111
Phone: +1-502-241-0456
Phone: +1-502-239-2110
Phone: +1-812-246-8880
Executive-Spa, Inc. is an upscale old-world massage parlor where you can get a great massage, at a fair price, and without the hassle of lengthy contracts. You can relax and experience the "World Class" art of massage in a private club like atmosphere.
Appointment is Required
Phone: +1-502-587-9598
Appointment is Required
Phone: +1-502-339-9931
Owner Denise Willinger is a esthetician and massage therapist with more than 30 years of experience. She has created an enticing, private environment where you can receive spa services without the hustle and bustle of a large impersonal salon.
Appointment is Required
Phone: +1-502-245-6484
At Z salon & Spa we believe our success stems from you and what you expect from us. Without you, the client, we would not be here. Z Salon & Spa offers a wide range of services and an experienced, professional team to pamper and enhance your image.
Appointment is Required
Phone: +1-502-426-2226


text:
Perfect for pizza or good value set menu. Not expensive, good service, nice atmoosphere. Set on ancient street in extraordinary medieval village.
Can anyone other than the Italians really make pizza? Not on the evidence of this restaurant. Mine had dough that was too thick and not cooked through; and the anchovy and olive topping was much too salty (even for anchovies). Actually a poor dish that I didn't finish. My wife, on the other hand, had some quite good rigatoni, which...
We stayed in Turckheim and this came recommended by others on the site. Excellent place with good service. I had a tagliatelle which was superb.
Not bad, pretty sure the owner is Italian so that's a good sign. Nothing spectacular but nothing not to visit over either. Service was grudgingly OK but that's typical in Europe.
We were walking around finding a place to eat and we decided to come her and we did not regret it. The food is good, the service is good, several options for children and we were happy we reached this place. Pizza and pasta are very good.
When in Turckheim we always have dinner at Pizzeria Roma at least once. The food is authentic italian and has always been very good. We normally eat the pastadishes which are good and of a decent size. Two entrees, two glasses of wine and two espressos cost us about 30 euro and that is a fair price for the amount...
Register now for free — and start getting automatic notification of new reviews, responding to traveler feedback, adding new photos to your listing and much more.


text:
'John Wick' Sequel Is "In Development"
Posted on Wednesday, February 4th, 2015 by Angie Han
John Wick is thinking he's back, again. Directors Chad Stahelski and David Leitch have revealed that they're in development on a sequel to the 2014 Keanu Reeves thriller, although details are scarce at the moment. After the jump, read their comments on a John Wick sequel. Read More »


text:
Mrs. Ishimoto is a teacher at Yamazakura elementary school. Her students enjoy ghost stories.
You must be logged in to leave comments. Login or sign up today!
There are no comments - leave one to be the first!
Don't want a popup? edit settings here
Gifted by .
If you liked or , you'd like the other because...
or, add different recommendations for


text:
'Edge screen is a show-off, and it makes for quicker multitasking.'
'Expensive. Curved screen serves no must-have purpose.'
'Full of features.'
'Beautiful, high-resolution curved display. '
'the E8's screen is very bright, and can reach the excellent 524 nits.'
'Powerful innards'
'polycarbonate back panel'
'The 1080p video recording is more than usable to share with friends and family.'
'Quick and easy transition from phone to tablet.'
'Photos captured using the camera were sharp and full of detail, though colors were too bright.'
'Ample horsepower.'
'wide viewing angles'
'The phone is available in your choice of white or black with faux chrome trim, and I think the visual and textural treatment looks nice.'
'the screen is larger without making the phone bigger.'
'It's a very sharp display, and even tiny text has superb clarity. '
'Interface and functionality
Huawei's new Emotion UI is simple, customizable and easy to master, with a pinch of helpful features.'
'Disappointing battery life'
'It is not remotely a match for phones like the Galaxy S5 and HTC One M8 in pure performance, though of course this still makes it a fairly powerful mobile. '
'the price of the Ascend P7 is very reasonable for a flagship smartphone.'
'Rock-solid built-in apps, but nothing fancy. '
'viewing angles were great and colors were vibrant.'
'Last year's MX3 was impressive in this regard as well but this year's phone is even better.'
'Chinese cult smash is well worth a risky import buy'
'Weekly updates, powerful kit and an undercutting price'
'Rebuilding the image of Chinese smartphones'
'Giant screen great for video and gaming. '
'Bad. Loudspeaker is not good.'
'A good 6in phablet that surprised us with its £250 price tag'
'It is big, bright, beautiful, and perfectly suitable for every task. '
'Thin and wide the overall impression is of ultimate portability, a robust handset with a nice if plasticky finish. '
'Image and video quality is very similar to the Samsung Galaxy S3 and Galaxy Note II, which is to say good but not as stunningly detailed as the S4. - Lastly, the phone has physical front buttons rather than capacitive.'
'Phone quality wise, the device is strong, with calls coming through crisp. '
'The camera has problems in focussing on subjects and is slow as well.'
ReviewGist helps you find the best products to buy by making sense of online reviews.
We are currently aggregating 368,204 reviews
covering over 29,103 products. See what the press says about ReviewGist here.
The Best Cellphone Buying Guide for 2014 is the definitive starting point for your next cellphone purchase.
© 2007-15 ReviewGist.com. All Rights Reserved.


text:
Find out about our history, mission and corporate structure, and the way we do business.
From food & beverages to home & personal care, our brands are part of everyday life.
Find out how we are making sustainability a driver of everything we do so that each time a consumer chooses one of our products, it improves their life, their community and the world we all share.
Learn how Unilever's innovations build leading brands and develop our capacity to meet consumer needs for nutrition, hygiene and personal care.
On any given day, two billion people worldwide use a Unilever product. From food, beverages and ice cream, to household and personal care products, our well-loved brands are part of everyday life and help people feel good, look good and get more out of life.
Axe launches its first fragrance for women+Axe is launching a new fragrance – Anarchy – which will be...Read more »
Vermont moves to #ActOnClimate as it pushes for a State Carbon Pollution Tax. Story > http://t.co/yrkIhdfaVv #climate http://t.co/P21Wsf1MsJ
Heat damage can't extinguish your style. Defend your hair from further damage with CLEAR. #VoiceKnockouts #IAMWHOIAM http://t.co/3flaCtRgFt
We never would have guessed today would be the day. This #BieberRoast is cooked and we've got a new man.
Confession time: who's slept in their makeup? Lucky Micellar Water cleanses & hydrates to refresh skin the morning after! #KindIsSimple
They're playing awesome #bball, but you're eating awesome-r food. Corn Crusted Pork Tenderloin http://t.co/ei9fTwLWNQ http://t.co/oa7FFQkgT7
Winter lasts 3 months, but you can moisturize to heal dry skin in just 5 days with Vaseline Advanced Repair lotion. http://t.co/cwXdRqOthA
Knorr reveals the greatest flavour on earth+Knorr's new film celebrates the emotional role that flavour plays...Read more »
Lux pioneers soap from algal oils+Lux has become the first soap brand in the world to use...Read more »
AXE/Lynx Black Presents: Welcome to the Jungle - Novo Amor+Axe Black presents a cover of Guns N' Roses' classic track...Play video »
Axe gets sophisticated with Axe Black+Axe is celebrating the launch of its subtle new range for men...Read more »
Magnum "Life and Death, New York" by Harvey Keitel - Cannes Lion Award Winning Film+Awarded with 4 Lions at the Cannes Lions International Festival...Play video »
Magnum Mini+The perfect mini size for pleasure whenever.Play video »
Magnum with Marc de Champagne for Magnum 25 years birthday+Magnum celebrates its 25th birthday with a limited edition ice...Play video »
Celebrating Magnum's 25th Birthday party with Kylie Minogue+An unforgettable event to celebrate our 25th birthday, from our...Play video »
Surf teams up with Bubble Saga+Surf has launched a special version of the Facebook game Bubble...Read more »
"Mrs Lawdy Daw" by Josh! Another great new advert by family favourite; Flora
Becel, Flora: Family life doesn't always go to plan but with Flora you can't go wrong, at least while baking! We know that family life doesn't always go right but one of the best things we can do is have...
Sunlight: Who knew? Hot water and lemon cleanses both you AND your dishes. The power of 100 lemons in Sunlight gives your dishes a beautiful clean
By 2015, we aim to source 100% of the cocoa in every Magnum from Rainforest Alliance-certified farms, giving farmers a fair deal.
Magnum: Always in fashion. To celebrate the beginning of fashion month, here's Stella Villela with her favourite edible accessory (and a chic #Fendi purse).
Lux creates body wash with long-lasting fragrance+Lux has unveiled the world's first body wash with Fragrance Touch...Read more »
Magnum's M-Pulse app brings together friends and ice cream+Magnum is making it easier for its fans to find and enjoy moments...Read more »
Dove Body Wash shows the power of just one shower +Dove has unlocked the key to softer and smoother skin after just...Read more »
Ten top scalp tips for men+Find out how you can keep your hair looking and feeling its best.Read more »
Scalp care tips for women+Check out these ten top tips to keep your hair looking and...Read more »
Simple advice to avoid dry and irritated skin+Teenagers suffering from problem skin may be tempted to pile on...Read more »
Lifebuoy shows how superheroes can save lives+Lifebuoy showed how superheroes really can save lives at Comic...Read more »
Be 'Kind to City Skin' with Simple+The grime and stress of fast-paced city living can take their...Read more »
Breakthrough Clear range ends recurring dandruff+Clear has reformulated its range of shampoos to 'dandruff-proof'...Read more »
Pond's reveals why Y is the new shape of youth+Pond's has unveiled its breakthrough Age Miracle Firm & Lift...Read more »
Spread the love on World Baking Day+Who will you be baking for on World Baking Day 2014?Read more »
Magnum celebrates turning 25 with Pleasure Hunt 4+Magnum is inviting its fans around the world to join the 'Biggest...Read more »
Vaseline introduces Spray & Go Moisturizers+Vaseline is making it easier and faster for women to moisturise...Read more »
Lifebuoy first brand to receive RSPH campaign accreditation+Lifebuoy has become the first-ever soap to receive the Royal...Read more »
Ben & Jerry's thanks fans with free ice cream+Ben & Jerry's Free Cone Day is back – and this year it's aiming...Read more »
Be More Tea with Lipton's new campaign+Lipton's Be More Tea campaign is all about encouraging people...Read more »
The world's first toothpaste just for men+Signal has launched the world's first toothpaste designed...Read more »
Ben & Jerry's Social Entrepreneur Pitching Event 2013: MAC UK & Spice
Ben & Jerry's: Ben & Jerry's and Ashoka are on the hunt for the best social entrepreneurs from Europe! Watch Charlie from Mac UK & Becky from Spice pitch to a panel of judges including our co-founder Jerry...
Omo believes that children should feel free to explore, learn and develop – and sometimes getting a few stains along the way is part of that process. It's how kids learn, express their creativity and even bolster their immune systems
More than 25 million Facebook fans can't be wrong. Keep up with the latest on Axe news on our brand pages around the world.
There is no content for the criteria you have selected. Please choose another option, or view all options.


text:
Welcome to Stockton College Fraternity & Sorority Life!
With close to 500 members and 23 chapters, we hope that you will find the Stockton Greek community has a home for everyone. Going to college means encountering new and exciting opportunities in an environment you may not be used to, and joining a fraternity or sorority may be a great chance to help you find a home away from home.
On campus you will find fraternities and sororities ranging from the "traditional" to historically African-American, Latino/a and multicultural. As a member, you will create lifelong friendships, strengthen academic skills, grow through leadership and service in a community of shared values, and have a lot of fun!
Our Mission
Fraternity and Sorority Life at the Richard Stockton College of New Jersey serves to develop college students in the areas of civic responsibility, leadership development, and personal growth.
We strive to foster an environment that expects, encourages and rewards academic excellence.
We strive to empower students to make a positive difference in the Stockton, local and worldwide community through promoting volunteerism, service and philanthropic efforts.
We strive to foster positive relationships with administrators, faculty, staff, students, alumni(ae), headquarters and other partners in order to encourage a unified campus community and network.
We strive to challenge thinking, promote diversity and cultivate personal development.
Our Core Values
Academic Achievement
Civic Responsibility
Leadership Development
Personal Growth
Lifelong Friendships
Each chapter is assessed annually in these areas through our Growth & Recognition Plan.
Interested in Joining?
Anyone wishing to join a fraternity or sorority must be on the Eligibility List. Fraternities and sororities may not give you a bid or membership invitation until you are on this list. To be on this list, you must meet the following requirements:
- You have completed a minimum of one full-time semester of college (at Stockton or Transferred - 12 credits)
- You have a 2.5 cumulative GPA (note: individual chapters may have a higher requirement)
- You are a full-time Stockton student
- You have registered here and completed the required educational components (note: you will be added to a Blackboard page where you will find instructions)
Please also check out the Join Our Community page!


text:
Pro Wrestling Since 1997
Nov 23, 2012 - by staff
Chief contributor and Ace Reporter Sean Banner reviews the 11/22 edition of TNA Impact Wrestling and 11/23 WWE Friday Night Smackdown. Was Banner thankful for this week's wrestling? Tune in and find out.
Post Category: Interviews, News
Tags: impact, Impact Wrestling, podcast, Smackdown, TNA, WWE
RT @gerweck: Podcast: Reviews of 11/22 #TNA Impact and 11/23 #WWE Smackdown (courtesy of @AstoriaSean) http://t.co/CSS3VyeH
Name (required)
Mail (required)
Greatest Female Wrestler tournament - Round 3 (West bracket)
View Results
Greatest Female Wrestler tournament - Round 3 (East bracket)
Should Chyna be inducted into the GERWECK.NET Hall of Fame?


text:
- Product Information
Product Description
Bring on the retro fun with our Tie Dye Balloons! These 11" tie dye latex balloons are the perfect addition to retro events, birthday parties, school dances, and other special occasions. Whether you want to spice up your party decor or fill out a balloon bouquet, these tie dye balloons are sure to please! These agate style tie dye latex balloons will add a fun and festive pop of color to any event. Our 11" Tie Dye Balloons are sold in bags of 25.
- Quantity-25
- Color-Assorted
- Size-11"
- Material-Latex
- Imprintable-No
- Quantity-25
- Questions & Answers
- Reviews
Customer Reviews
- Full of color.Great Quality.Long Lasting Review by JoJo
Decorated for a 60's Woodstock theme party! Full of color..attracted attention..added fun to the party.
(Posted on 9/12/13)
- Awesome Balloons Review by Girl on Fire
We used them for our Y week and they looked awesome!
(Posted on 5/4/13)
- great quality product Review by Hippie at heart
These were used as a promotion for my business and they were a hit.
(Posted on 3/4/13)
- wedding balloons Review by dreader
We used these to decorate the road to the wedding venue. They were perfect for the theme.
(Posted on 8/12/12)
- Got so many compliments! Review by Table decorator
We had a 60's theme at the church for the youth. These were so cute and perfect for the 60's decorations.
(Posted on 4/11/12)
Write Your Own Review
Spend a Day in Paris with a Paris Party!
Add a Paris theme to any type of soiree with the help of Paris decorations and French treats. Use these party planning tips and ideas to help you prepare for your party!
Totally 80's Party Ideas
Add an 80's theme to an upcoming party of event! Use these party tips to help you set up for an 80's theme party, complete with decorations, food ideas and more.
Add a Pink and Gold Color Scheme to Your Party!
Throwing a party? Try using a mix of pink and gold colors to create the color scheme for your party décor. This color combination can be used for birthday parties, bridal parties, baby showers, and much more!


text:
Subscribe to TESOL Blog
TESOL English Language Bulletin
- Education Department pledges to prioritize needs of language learners 26 March 2015
- New study to examine Aussie English 26 March 2015
- New report offers state leaders, Feds advice to improve ELL education 26 March 2015
- International students stream into US colleges 26 March 2015
- Simple exercises to improve ELL reading skills — Part 2 26 March 2015
TESOL Videos
TESOL president, speaks about TESOL.
Tag Archives: analysis
Figuring out the frequency of two word verbs
The December 2011 TESOL Quarterly contains a wonderful study by Dilin Liu analyzing the frequency of phrasal verbs across several corpora. This is a really useful article for teachers and materials writers, with lots of great information in it and … Continue reading
Posted in TESOL Blog Tagged as analysis, corpus, Dilin Liu, ELT, ESL, frequency, idioms, Joe McVeigh, phrasal verbs, teaching, TESOL Quarterly, two-word verbs 2 Comments


text:
"I was able to personalize these gift tags w/ the full date of the shower and then used them as sticker's to make keepsake book marks for my sister's guests! (we did a book-themed party since we didn't know the baby's gender of the baby!) Everyone loved them. We also used the stickers as cupcake toppers! We stuck them on different colored cardstock and cut them out, leaving just about an 1/8 inch edge and stuck them in our cupcakes - perfect complimentary shower decorations! Oh - we changed the graphic from the heart to the question-mark so it would match the invitations. So simple to make that request and Tiny Prints called and sent proofs showing me what it would look like both ways. So professional and courteous. I will definitely order from them again!"
"Love these for my space obsessed son. Would have liked an option to put "To ____" and then "From ____" instead of just a single name. Great nonetheless."
"Put them on the back of an envelope, seal a gift bag -- or a gift diaper? Use them for a save the date card. The possibilities are numerous."
"I personalized these tags for my SIL's upcoming baby shower. She's having a little boy and I thought they were perfect for a more contemporary look."
"The pumpkin high chair stickers added a special touch to the favor bags as well as the candle holders. They matched the invitations which helped tie into the theme. Very good quality."


text:
PayPal and eBay are easily the most common brands used in online scams, a PhishTank report reveals.
The inaugural report — based on the end-user submission of almost 300,000 emails believed to be phishes — shows PayPal and its parent eBay served as the lure in 63,437 verified phishing emails.
PayPal was spoofed in 31,719 emails, while the eBay name was faked in just one fewer email, according to the report from PhishTank, a community-based anti-phishing service. U.K.-based Barclays Bank came in a distant third, with 6,515 verified phishes spoofing the brand. Bank of America (5,727) and Fifth Third Bank (4,191) rounded out the top five.
Millions of people retire in poverty - but it doesnt have to be this way!
And start making money when they buy what they're already buying
Earn recurring monthly payments selling mobile websites and apps to local businesses.
Be a part of the number one growth industry while securing your future with residual income.
Amazing opportunity for only $500 in an industry that is prime for sales.
Earn $3,000+ per Transaction Brokering Notes
Turn-key mobile loyalty app business. No experience needed!
What could be better than earning up to 100% commission on the sales of exciting cruise and destination vacation packages?
Start a revolutionary printing company for a lot less than you think!
Start a local Social Media and online reputation business. No experienced needed! Only $99 to get started.


text:
There are no emergency-level disruptions of MTA service at this time. Click here to return to the regular MTA website.
For your safety
You are viewing a temporary website for New York's Metropolitan Transportation Authority. This site is activated only during severe, inclement weather conditions or in the event of an emergency. Access to the MTA's regular site may or may not be available from this page depending on activity and traffic to the site.
© Copyright 2015 Metropolitan Transportation Authority. A public benefit corporation chartered by the State of New York. Internet Privacy Policy
Top of page
Open the original version of this page.
Usablenet Assistive is a UsableNet product. Usablenet Assistive Main Page.


text:
Circulation Desk
Research Help
Posted by akeck001 on Wednesday, December 04, 2013 4:06 PM
Records from the Reformation Research Library, North America's most extensive collections of sixteenth century imprints in microform, have been added to our new library catalog.
Since 1986, Luther Seminary's Reformation Research Program has been building this collection of over 42,000 titles to meet the needs of researchers.
Thanks especially to Mary Ann Teske who spent countless hours doing some final cleanup as well as Ted Wilder, Director of the Office of Technology and Dr. Mary Jane Haemig, Director of the Reformation Research Program for working with the library to make this project possible.
Tags: akeck001
March 1-April 30M-Th 7:45am-10pmFriday 7:45am-5pmSaturday 1-5pmSunday 6-10pm
April 1-2 & 6 8am-5pmApril 3-5 Closed
Welcome Login to participate.