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Publications (35)168.58 Total impact
Article: Comparison of Effects of Pitavastatin Versus Pravastatin on Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels in Statin-Naive Patients With Coronary Artery Disease[Show abstract] [Hide abstract]
ABSTRACT: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of serum low-density lipoprotein cholesterol levels. Although statins increase serum PCSK9 levels, the effects of different types of statins on the serum PCSK9 levels have not been examined in detail. The purpose of the present study was to compare the effects of pitavastatin versus pravastatin on the serum PCSK9 levels. A total of 164 patients with coronary artery disease who were not receiving lipid-lowering therapy were randomly assigned to receive either 4 mg/day of pitavastatin (intensive lipid-lowering therapy) or 20 mg/day of pravastatin (moderate lipid-lowering therapy). The serum PCSK9 levels were measured before statin treatment and 8 months after therapy. A significantly greater reduction in low-density lipoprotein cholesterol was observed in the pitavastatin group (-41% vs -28%, p = 0.0001). The serum levels of total PCSK9 and heterodimer PCSK9 significantly increased from 192 to 249 ng/ml (37%, p <0.0001) and 147 to 206 ng/ml (78%, p <0.0001) in the pitavastatin group and from 192 to 249 ng/ml (39%, p <0.0001) and 143 to 201 ng/ml (65%, p <0.0001) in the pravastatin group, respectively. The increase in total and heterodimer PSCK9 did not differ between the 2 groups. No significant correlations were found between the percentage of changes in heterodimer PCSK9 and changes in the various lipid parameters in either group. In conclusion, significant increases in the total and heterodimer PSCK9 levels were observed at 8 months after treatment with pitavastatin and pravastatin; however, these increases did not differ between the 2 statins.The American journal of cardiology 02/2013; 111(10). DOI:10.1016/j.amjcard.2013.01.289 · 3.58 Impact Factor
Article: Clinical Significance of Plasma Apolipoprotein F in Japanese Healthy and Hypertriglyceridemic Subjects.[Show abstract] [Hide abstract]
ABSTRACT: Aim: Apolipoprotein F (apo F), also known as lipid transfer inhibitory protein (LTIP), is a protein component of plasma lipoprotein classes including HDL and functions to inhibit lipid transfer between lipoproteins in vitro. To study the role of plasma apo F, a reliable and sensitive tool for the quantification would be needed.Methods: We have developed a sandwich ELISA using two monoclonal antibodies for human plasma apo F, and analyzed apo F concentration in 397 Japanese healthy and 221 hypertriglyceridemic subjects.Results: Our ELISA enables apo F to be assayed in the range of 0.6-25 µg/mL with intra- and inter-assay coefficients of variation less than 3.8% and 7.8%, respectively. In healthy subjects, plasma apo F concentration was 12.5±2.9 µg/mL (mean±SD), and was significantly higher in females than in males (p<0.05). By linear regression analysis in healthy subjects, plasma apo F concentration correlated positively with HDL cholesterol and apo A-I levels, and in males but not in females, negatively with apo B and triglyceride levels. It also correlated negatively with intrinsic CETP activity measured using intrinsic apo B-containing lipoprotein as an acceptor, and positively with PLTP mass and apo J levels. Apo F concentration in hypertriglyceridemic patients (10.3±3.1 µg/mL) was lower than in healthy controls (p<0.0001) and correlated positively with PLTP mass.Conclusions: Our ELISA is reliable and sensitive for the quantification of plasma apo F concentration. This system can be applicable for clinical significance in lipoprotein metabolism and reverse cholesterol transport.Journal of atherosclerosis and thrombosis 02/2013; DOI:10.5551/jat.13706 · 2.93 Impact Factor
Article: Lipoprotein remodeling generates lipid-poor apolipoprotein A-I particles in human interstitial fluid.[Show abstract] [Hide abstract]
ABSTRACT: Although much is known about the remodeling of high density lipoproteins (HDLs) in blood, there is no information on that in interstitial fluid, where it might have a major impact on the transport of cholesterol from cells. We incubated plasma and afferent (pre-nodal) peripheral lymph from ten healthy men at 37°C in vitro, and followed the changes in HDL subclasses by non-denaturing two-dimensional crossed immunoelectrophoresis and size exclusion chromatography. In plasma, there was always initially a net conversion of small preβ-HDLs to cholesteryl ester (CE) rich α-HDLs. By contrast, in lymph there was only net production of preβ-HDLs from α-HDLs. Endogenous cholesterol esterification rate, cholesteryl ester transfer protein (CETP) concentration, CE transfer activity, phospholipid transfer protein (PLTP) concentration, and phospholipid transfer activity in lymph averaged 5.0, 10.4, 8.2, 25.0 and 82.0% of those in plasma, respectively (all P < 0.02). Lymph PLTP concentration, but not PL transfer activity, was positively correlated with that in plasma (r = + 0.63, P = 0.05). Mean PLTP specific activity was 3.5 fold greater in lymph, reflecting a greater proportion of the high-activity form of PLTP. These findings suggest that cholesterol esterification rate and PLTP specific activity are differentially regulated in the two matrices in accordance with the requirements of reverse cholesterol transport, generating lipid-poor preβ-HDLs in the extracellular matrix for cholesterol uptake from neighbouring cells, and converting preβ-HDLs to α-HDLs in plasma for the delivery of cell-derived CEs to the liver.AJP Endocrinology and Metabolism 12/2012; DOI:10.1152/ajpendo.00324.2012 · 4.51 Impact Factor
Article: Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study.[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVES: We assessed the association between serum autoantibodies against the 70-kDa polypeptide of the U1-ribonucleoprotein (RNP) complex (U1-70k) and the central nervous system (CNS) syndromes in systemic lupus erythematosus (SLE) patients. METHODS: We studied 106 hospitalized patients with active SLE, comparing those with (n = 32) and without (n = 74) CNS syndromes. CNS syndromes were further classified into neurologic (n = 21) and psychiatric (n = 15) disorders. Immunoglobulin G (IgG) anti-U1-70k antibodies were measured by enzyme-linked immunosorbent assay (ELISA) using recombinant antigens. IgG antibodies against whole U1-RNP were measured using commercial ELISA kits. RESULTS: Although there was no significant difference in the levels of serum anti-U1-70k antibodies in SLE patients with or without CNS syndromes (p = 0.83), the levels were significantly elevated in SLE patients compared with patients without psychiatric syndromes (p = 0.030). In contrast, no significant difference was observed in the levels of serum anti-U1-RNP antibodies in SLE patients with or without psychiatric syndromes (p = 0.555). CONCLUSIONS: These results indicate that serum anti-U1-70k antibodies are associated with psychiatric syndromes in SLE but that they are not associated with CNS syndromes as a whole or with neurologic syndromes. The anti-U1-70k antibodies might be involved in the pathological mechanisms of psychiatric syndromes in SLE.Modern Rheumatology 03/2012; 23(1). DOI:10.1007/s10165-012-0624-y · 2.21 Impact Factor
Article: Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: Effect of a high-dose statin on VLDL receptor expression[Show abstract] [Hide abstract]
ABSTRACT: Comparison of the reactivity of remnant-like lipoprotein particles (RLP) and LDL particles to LDL receptor and VLDL receptor has not been investigated. LDL receptor- or VLDL receptor-transfected ldlA-7, HepG2 and L6 cells were used. Human LDL and rabbit β-VLDL were isolated by ultracentrifugation. Human RLP was isolated using an immunoaffinity mixed gel. The effect of statin on lipoprotein receptors was examined. Both LDL receptor and VLDL receptor recognized RLP. In LDL receptor transfectants, RLP, β-VLDL and LDL all bound to LDL receptor. Cold RLP competed efficiently with DiI-β-VLDL; however, cold LDL competed weakly. In VLDL receptor transfectants, RLP and β-VLDL bound to VLDL receptor, but not LDL. RLP bound to VLDL receptor with higher affinity than β-VLDL because of higher apolipoprotein E in RLP. LDL receptor expression was induced in HepG2 by the low concentration of statin while VLDL receptor expression was induced in L6 myoblasts at higher concentration. RLP are bound to hepatic LDL receptor more efficiently than LDL, which may explain the mechanism by which statins prevent cardiovascular risk by primarily reducing plasma RLP rather than by reducing LDL. Additionally, a high-dose of statins also may reduce plasma RLP through muscular VLDL receptor.Clinica chimica acta; international journal of clinical chemistry 11/2011; 413(3-4):441-7. DOI:10.1016/j.cca.2011.10.033 · 2.54 Impact Factor
Article: Identification of three new autoantibodies associated with systemic lupus erythematosus using two proteomic approaches.[Show abstract] [Hide abstract]
ABSTRACT: Our objective was to identify new serum autoantibodies associated with systemic lupus erythematosus (SLE), focusing on those found in patients with central nervous system (CNS) syndromes. Autoantigens in human brain proteins were screened by multiple proteomic analyses: two-dimensional polyacrylamide gel electrophoresis/Western blots followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis and immunoprecipitation followed by liquid chromatography-tandem mass spectrometry shotgun analysis. The presence of serum IgG autoantibodies against 11 selected recombinant antigens was assessed by Western blot and enzyme-linked immunosorbent assay (ELISA) in the sera of 106 SLE patients and 100 normal healthy controls. The O.D. values in sera from SLE patients were significantly higher than those of controls for the antigens crystallin αB (p = 0.0002), esterase D (p = 0.0002), APEX nuclease 1 (p < 0.0001), ribosomal protein P0 (p < 0.0001), and PA28γ (p = 0.0005); the first three are newly reported. The anti-esterase D antibody levels were significantly higher in the CNS group than in the non-CNS group (p = 0.016). Moreover, when the SLE patients were categorized using CNS manifestations indicating neurologic or psychiatric disorders, the anti-APEX nuclease 1 antibody levels were significantly elevated in SLE patients with psychiatric disorders (p = 0.037). In conclusion, the association of SLE with several new and previously reported autoantibodies has been demonstrated. Statistically significant associations between anti-esterase D antibodies and CNS syndromes as well as between anti-APEX nuclease 1 antibodies and psychiatric disorders in SLE were also demonstrated. The combined immunoproteomic approaches used in this study are reliable and effective methods for identifying SLE autoantigens.Molecular & Cellular Proteomics 06/2011; 10(6):M110.005330. DOI:10.1074/mcp.M110.005330 · 7.25 Impact Factor
Article: Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression.[Show abstract] [Hide abstract]
ABSTRACT: Triglyceride-rich lipoproteins (TGRLs) and low-density-lipoprotein (LDL) cholesterol are independent risk factors for coronary artery disease. We have previously proposed that the very low-density-lipoprotein (VLDL) receptor is one of the receptors required for foam cell formation by TGRLs in human macrophages. However, the VLDL receptor proteins have not been detected in atherosclerotic lesions of several animal models. Here we showed no VLDL receptor protein was detected in mouse macrophage cell lines (Raw264.7 and J774.2) or in mouse peritoneal macrophages in vitro. Furthermore, no VLDL receptor protein was detected in macrophages in atherosclerotic lesions of chow-fed apolipoprotein E-deficient or cholesterol-fed LDL receptor-deficient mice in vivo. In contrast, macrophage VLDL receptor protein was clearly detected in human macrophages in vitro and in atherosclerotic lesions in myocardial infarction-prone Watanabe-heritable hyperlipidemic (WHHLMI) rabbits in vivo. There are species differences in the localization of VLDL receptor protein in vitro and in vivo. Since VLDL receptor is expressed on macrophages in atheromatous plaques of both rabbit and human but not in mouse models, the mechanisms of atherogenesis and/or growth of atherosclerotic lesions in mouse models may be partly different from those of humans and rabbits.Biochemical and Biophysical Research Communications 03/2011; 407(4):656-62. DOI:10.1016/j.bbrc.2011.03.069 · 2.28 Impact Factor
Atherosclerosis 05/2009; 207(1):24-5. DOI:10.1016/j.atherosclerosis.2009.03.046 · 3.71 Impact Factor
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ABSTRACT: An efficient route for delivering specific proteins and peptides into neurons could greatly accelerate the development of therapies for various diseases, especially those involving intracellular defects such as Parkinson disease. Here we report the novel use of polybutylcyanoacrylate nanoparticles for delivery of intact, functional proteins into neurons and neuronal cell lines. Uptake of these particles is primarily dependent on endocytosis via the low density lipoprotein receptor. The nanoparticles are rapidly turned over and display minimal toxicity to cultured neurons. Delivery of three different functional cargo proteins is demonstrated. When primary neuronal cultures are treated with recombinant Escherichia coli beta-galactosidase as nanoparticle cargo, persistent enzyme activity is measured beyond the period of nanoparticle degradation. Delivery of the small GTPase rhoG induces neurite outgrowth and differentiation in PC12 cells. Finally, a monoclonal antibody directed against synuclein is capable of interacting with endogenous alpha-synuclein in cultured neurons following delivery via nanoparticles. Polybutylcyanoacrylate nanoparticles are thus useful for intracellular protein delivery in vitro and have potential as carriers of therapeutic proteins for treatment of neuronal disorders in vivo.Journal of Biological Chemistry 02/2009; 284(11):6972-81. DOI:10.1074/jbc.M805956200 · 4.60 Impact Factor
Article: Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells.[Show abstract] [Hide abstract]
ABSTRACT: Glucose and fatty acids are major energy sources in skeletal muscle. Very low-density lipoprotein receptor (VLDL-R), which is highly expressed in heart, skeletal muscle and adipose tissue, plays a crucial role in metabolism of triglyceride (TG)-rich lipoproteins. To explore energy switching between glucose and fatty acids, we studied expression of VLDL-R and lipoprotein uptake in rat L6 myoblasts. l-Glucose or d-glucose deprivation in the medium noticeably induced the AMPK (AMP-activated protein kinase) activation and VLDL-R expression. Dose-dependent induction of VLDL-R expression was observed when d-glucose was less than 4.2mM. The same phenomenon was also observed in rat primary skeletal myoblasts and cultured vascular smooth muscle cells. The uptake of beta-VLDL but not LDL was accompanied by induction of VLDL-R expression. Our study suggests that the VLDL-R-mediated uptake of TG-rich lipoproteins might compensate for glucose shortfall through AMPK activation in skeletal muscle.Biochemical and Biophysical Research Communications 05/2008; 368(3):716-22. DOI:10.1016/j.bbrc.2008.01.154 · 2.28 Impact Factor
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ABSTRACT: Apolipoprotein (apo) J, clusterin, is ubiquitously expressed in many tissues, and is a component of high-density lipoproteins (HDLs). There is experimental evidence that it may be anti-atherogenic through its effects on cholesterol transport, smooth muscle cell proliferation and lipid peroxidation. HDLs containing apo J and apo A-I carry paraoxonase (PON1), which protects low-density lipoproteins from oxidative modification; however, the extent to which apo J affects coronary heart disease (CHD) is not known. We have developed a sandwich ELISA that enables apo J to be assayed in the range of 13-200 microg/mL. Serum apo J was 52.8+/-0.8 microg/mL (mean+/-SEM; range, 36.0-84.3 microg/mL; n=92) in healthy Japanese men, and 49.3+/-0.5 microg/mL (34.5-72.8; n=241) in healthy Japanese women. Multiple regression of these data and results from 67 men with CHD showed that apo J concentration was unrelated to age, sex or body mass index, but was positively related to serum PON1 (p<0.001) and apo B (p<0.02) concentrations. In women, it was also positively related to blood glucose (p<0.02). After adjusting for its associations with covariates, serum apo J averaged 5.4 microg/mL, lower in CHD men than in controls (p<0.003). Type 2 diabetics had higher apo J concentrations (men, 83.1+/-3.4 microg/mL, n=64; women, 64.0+/-2.3 microg/mL, n=46) than healthy men and women (p<0.001). In these Type 2 diabetics, apo J concentration was unrelated to PON1 concentration, but was positively related to blood glucose (p<0.01). After adjustment for its relation to blood glucose, the mean apo J concentration was similar in diabetics and healthy subjects. These findings suggest that apo J may be anti-atherogenic in humans, and that its concentration is raised by Type 2 diabetes.Journal of atherosclerosis and thrombosis 12/2006; 13(6):314-22. DOI:10.5551/jat.13.314 · 2.77 Impact Factor
Article: Changes in cardiac lipid metabolism during sepsis: The essential role of very low-density lipoprotein receptors[Show abstract] [Hide abstract]
ABSTRACT: Sepsis accompanies myocardial dysfunction and dynamic alterations of cardiac metabolism. We have recently demonstrated that the very low-density lipoprotein receptor (VLDL-R), which is abundantly expressed in the heart, plays a key role in energy metabolism of the fasting heart. However, little is known about the function and regulation of the VLDL-R during sepsis. In the present study, we explored lipid accumulation and VLDL-R expression in the lipopolysaccharide (LPS)-stimulated heart in vivo and regulation of VLDL-R expression in vitro. Electron microscopy and immunohistochemistry demonstrated that LPS significantly decreased both lipid accumulation and VLDL-R expression in the hearts of fasting mice. Treatment with LPS also downregulated VLDL-R in rat neonatal cardiac myocytes, and this downregulation was completely reversed by interleukin (IL)-1beta receptor antagonist. IL-1beta downregulated the expression of VLDL-R in a time- and dose-dependent manner and markedly reduced the uptake of DiI-labeled beta-VLDL but not DiI-labeled low-density lipoprotein (LDL). Use of specific pharmacologic inhibitors and short interference RNA revealed that Hsp90 was required for IL-1beta to downregulate VLDL-R expression. These findings suggest that IL-1beta is a principle mediator of changes in cardiac lipid and energy metabolism during sepsis through the downregulation of myocardial VLDL-R expression.Cardiovascular Research 03/2006; 69(2):545-55. DOI:10.1016/j.cardiores.2005.11.014 · 5.81 Impact Factor
Article: Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase[Show abstract] [Hide abstract]
ABSTRACT: Oxidation of low density lipoprotein (LDL) is a critical step for atherogenesis, and the role of the 12/15-lipoxygenase (12/15-LOX) as well as LDL receptor-related protein (LRP) expressed in macrophages in this process has been suggested. The oxygenation of cholesteryl linoleate in LDL by mouse macrophage-like J774A.1 cells overexpressing 12/15-LOX was inhibited by an anti-LRP antibody but not by an anti-LDL receptor antibody. When the cells were incubated with LDL double-labeled by [3H]cholesteryl linoleate and [125I]apoB, association with the cells of [3H]cholesteryl linoleate expressed as LDL protein equivalent exceeded that of [125I]apoB, indicating selective uptake of [3H]cholesteryl linoleate from LDL to these cells. An anti-LRP antibody inhibited the selective uptake of [3H]cholesteryl ester by 62% and 81% with the 12/15-LOX-expressing cells and macrophages, respectively. Furthermore, addition of LDL to the culture medium of the [3H]cholesteryl linoleate-labeled 12/15-LOX-expressing cells increased the release of [3H]cholesteryl linoleate to the medium in LDL concentration- and time-dependent manners. The transport of [3H]cholesteryl linoleate from the cells to LDL was also inhibited by an anti-LRP antibody by 75%. These results strongly suggest that LRP contributes to the LDL oxidation by 12/15-LOX in macrophages by selective uptake and efflux of cholesteryl ester in the LDL particle.Biochemical and Biophysical Research Communications 01/2006; 338(1):128-35. DOI:10.1016/j.bbrc.2005.07.182 · 2.28 Impact Factor
Article: A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration.[Show abstract] [Hide abstract]
ABSTRACT: Apolipoprotein A-V (apoA-V) is a recently discovered apolipoprotein that appears to have a role in plasma triglyceride (TG) transport. We have developed an ELISA for apoA-V using monoclonal antibodies that has a lower limit of detection of 0.3 ng/ml and linearity up to 20 ng/ml. The ELISA was then used to quantify plasma apoA-V in 196 healthy subjects and 106 patients with insulin-resistant diabetes mellitus. In the healthy subjects, total apoA-V concentration was 179.2 +/- 74.8 ng/ml, and it was greater in females than in males (P < 0.005). It was correlated positively with the plasma HDL cholesterol (r = 0.32, P < 0.0001), apoA-I (r = 0.27, P = 0.0001), and apoE (r = 0.18, P = 0.011) concentrations and negatively with plasma TG concentration (r = -0.22, P = 0.021). In relation to single nucleotide polymorphism 3 (-1131C/T) of the apoA-V gene, apoA-V concentration was higher in the T/T type than in the C/C type (P < 0.01). Plasma TG concentration was lower in the T/T type than in the C/C or C/T type (P < 0.05). ApoA-V concentration was lower in the diabetic patients (69.4 +/- 44.3 ng/ml; P < 0.01) than in the healthy controls.The Journal of Lipid Research 10/2005; 46(9):2015-22. DOI:10.1194/jlr.D500018-JLR200 · 4.73 Impact Factor
Article: Deficiency of the very low-density lipoprotein (VLDL) receptors in streptozotocin-induced diabetic rats: Insulin dependency of the VLDL receptor[Show abstract] [Hide abstract]
ABSTRACT: Hyperlipidemia is a common feature of diabetes and is related to cardiovascular disease. The very low-density lipoprotein receptor (VLDL-R) is a member of the low-density lipoprotein receptor (LDL-R) family. It binds and internalizes triglyceride-rich lipoproteins with high specificity. We examined the etiology of hyperlipidemia in the insulin-deficient state. VLDL-R expression in heart and skeletal muscle were measured in rats with streptozotocin (STZ)-induced diabetes. STZ rats showed severe hyperlipidemia on d 21 and 28, with a dramatic decline in VLDL-R protein in skeletal muscle (>90%), heart (approximately 50%) and a loss of adipose tissues itself on d 28. The reduction of VLDL-R protein in skeletal muscle could not be explained simply by a decrease at the transcriptional level, because a dissociation between VLDL-R protein and mRNA expression was observed. The expression of LDL-R and LDL-R-related protein in liver showed no consistent changes. Furthermore, no effect on VLDL-triglyceride production in liver was observed in STZ rats. A decrease in postheparin plasma lipoprotein lipase activity started on d 7 and continued to d 28 at the 50% level even though severe hyperlipidemia was detected only on d 21 and 28. In rat myoblast cells, serum deprivation for 24 h induced a reduction in VLDL-R proteins. Insulin (10(-6) m), but not IGF-I (10 ng/ml), restored the decreased VLDL-R proteins by serum deprivation. These results suggest that the combination of VLDL-R deficiency and reduced plasma lipoprotein lipase activity may be responsible for severe hyperlipidemia in insulin-deficient diabetes.Endocrinology 09/2005; 146(8):3286-94. DOI:10.1210/en.2005-0043 · 4.64 Impact Factor
Article: Interleukin-1beta attenuates beta-very low-density lipoprotein uptake and its receptor expression in vascular smooth muscle cells.[Show abstract] [Hide abstract]
ABSTRACT: The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor gene family with distinct tissue distribution and function. VLDL receptors are also expressed in vascular smooth muscle cells (VSMCs) and have been shown to be upregulated in atherosclerotic lesions. In the present study, we examined the effects of interleukin-1beta (IL-1beta) on the uptake of betaVLDL and its receptor expression in rat VSMCs. IL-1beta downregulated expression of the VLDL receptor in a time and dose-dependent manner as shown by Western blotting, Northern blotting, and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Treatment with IL-1beta significantly reduced the uptake of beta-VLDL but not LDL in VSMCs. Use of specific pharmacologic inhibitors indicated that the tyrosine kinase inhibitors, herbimycin A and geldanamycin, completely reversed IL-1beta-induced downregulation of the VLDL receptor expression. Another tyrosine kinase inhibitor, genistein, the protein kinase C inhibitors, GF109203X and H7, the mitogen-activated protein (MAP) kinase inhibitors (MEK inhibitor PD098059 for [MEK] and SB203580 for p38-MAP kinase), and the protein kinase A inhibitor, KT5270 all had no effect on receptor expression. In addition, the c-Src specific inhibitor PP2 or adenoviral-mediated gene transfer of kinase inactive (KI)-c-Src failed to reverse IL-1beta-induced downregulation of VLDL receptor expression. These results indicate that IL-1beta attenuates uptake of VLDL through downregulation of its receptor in VSMCs, and that this downregulation is mediated through a benzoquinone ansamycin-dependent but c-Src-independent pathway.Journal of Molecular and Cellular Cardiology 05/2005; 38(4):637-46. DOI:10.1016/j.yjmcc.2005.02.006 · 5.22 Impact Factor
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ABSTRACT: Apolipoprotein E receptor 2 (apoER2) is a receptor for apolipoprotein E containing lipoprotein and also for Reelin. Apolipoprotein E-associated risk of developing Alzheimer's disease (AD) may be related to its binding to and clearance by cell surface receptors, including members of the low-density lipoprotein receptor family. Otherwise there is circumstantial evidence that the Reelin signaling pathway may contribute to neurodegeneration in AD. To investigate the role of apoER2 on amyloid deposition and neurodegeneration in vivo, we examined the presence of apoER2 in the brains of APP sw transgenic mice (Tg2576) using three apoER2 monoclonal antibodies. Our immunohistochemical study revealed that apoER2 was localized in fine granular structure and reactive astrocytes surrounding amyloid plaques. The double labeling immunohistochemistry revealed that this granular structure overlaps synaptophysin-positive dystrophic neurites. These findings indicate that neuronal apoER2 may play a role for amyloid deposition and neuronal degeneration in AD.Neuroscience Letters 10/2004; 368(2):144-7. DOI:10.1016/j.neulet.2004.06.081 · 2.06 Impact Factor
Article: Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on paraoxonase and platelet-activating factor acetylhydrolase in human plasma and tissue fluid[Show abstract] [Hide abstract]
ABSTRACT: We have previously shown that intravenous apolipoprotein (apo) A-I/phosphatidylcholine (apo A-I/PC) discs increase plasma high-density lipoprotein (HDL) concentration in humans. We have now studied the associated changes in two enzymes, paraoxonase (PON) and platelet-activating factor acetylhydrolase (PAF-AH) that are carried in whole or in part by HDLs, and are thought to influence atherogenesis by hydrolyzing oxidized phospholipids in lipoproteins. Apo A-I/PC discs (40 mg/kg over 4 h) were infused into eight healthy males. Although plasma apo A-I and HDL cholesterol increased on average by 178 and 158%, respectively, plasma total PON and total PAF-AH concentrations did not rise. By the end of the infusion, HDL-associated PAF-AH had increased by 0.56 +/- 0.14 microg/mL (mean +/- S.D., P < 0.01), and nonHDL-associated PAF-AH had decreased by 0.84 +/- 0.11 microg/mL (P < 0.05). These changes were accompanied by an increase in the HDL-associated PAF-AH/apo A-I ratio from 0.19 to 0.35 (P < 0.05), and by a decrease in the nonHDL-associated PAF-AH/apo B ratio from 2.1 to 1.4 (P < 0.05). No changes in PON or PAF-AH concentrations were detected in prenodal lymph (tissue fluid), collected continuously from the leg. Our results show that the total concentrations of PON and PAF-AH in plasma are uninfluenced by plasma HDL concentration. PAF-AH transfers readily between HDLs and LDLs in vivo, and its distribution between them is determined partly by their relative concentrations and partly by HDL composition.Atherosclerosis 10/2004; 176(1):57-62. DOI:10.1016/j.atherosclerosis.2004.03.026 · 3.97 Impact Factor
Article: The important role for betaVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor.[Show abstract] [Hide abstract]
ABSTRACT: The low-density lipoprotein (LDL) receptor (LDLR) is a crucial role for binding and uptaking apolipoprotein (apo) B-containing lipoproteins, such as very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and LDL. The defect function of the LDLR causes familial hypercholesterolemia (FH), the phenotype of which is elevated plasma cholesterol and premature coronary heart disease (CHD). In the present study, we characterize the role of the cysteine residue of the ligand-binding domain of the LDLR. The mutant LDLR protein of cysteine for serine at codon 25 (25S-LDLR) was expressed in Chinese hamster ovary (CHO) cell line, ldl-A7. By Western blot analysis, the 25S-LDLR was detected with monoclonal antibody IgG-12D10, which reacts with the linker site of the LDLR but not with IgG-C7, which reacts with the NH2 terminus of the receptor. The 25S-LDLR bound LDL similarly to the wild-type LDLR, but the rate of uptake of LDL by the mutant receptor was only about half of that by the wild-type receptor. In contrast, the 25S-LDLR bound and internalized beta VLDL more avidly than LDL. These results suggest that the fourth cysteine residue of the first ligand-binding domain of the LDLR might be important for the internalization of atherogenic lipoproteins by vascular cells despite reduced LDL uptake, leading to atherosclerosis and premature cardiovascular disease.Journal of Human Genetics 02/2004; 49(11):622-8. DOI:10.1007/s10038-004-0198-4 · 2.53 Impact Factor
Article: Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients.[Show abstract] [Hide abstract]
ABSTRACT: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor (PAF) acetylhydrolase (PAF-AH), is a member of the serine-dependent class of A2 phospholipases that hydrolyze sn2-ester bonds of fragmented or oxidized phospholipids at sites where atherosclerotic plaques are forming. Most circulating Lp-PLA2 is bound to low-density lipoprotein (LDL) particles in plasma and the rest to high-density lipoprotein (HDL). Deficiency of Lp-PLA2 is a predisposing factor for cardiovascular diseases in the Japanese population. We describe here two novel mutations of the gene encoding Lp-PLA2, InsA191 and I317N in Japanese subjects. The first patient, with partial Lp-PLA2 deficiency, was heterozygous for the InsA191 mutation; macrophages from this patient secreted only half the normal amount of Lp-PLA2 in vitro. The other patient, who showed complete Lp-PLA2 deficiency, was a compound heterozygote for the novel I317N mutation and a common V279F mutation; macrophages from that patient failed to secrete any Lp-PLA2. Measurement of Lp-PLA2 mass, activity and Western blotting verified impaired production and secretion of the enzyme after transfection of mutant construct into COS-7 cells. These results indicated that both novel mutants, InsA191 and I317N, impair function of the Lp-PLA2 gene.Journal of Human Genetics 02/2004; 49(6):302-7. DOI:10.1007/s10038-004-0151-6 · 2.53 Impact Factor
Top Journals
National Institute of Infectious Diseases, TokyoEdo, Tōkyō, Japan
Hiratsuka Kyosai HospitalHiratuka, Kanagawa, Japan
Health Sciences University of HokkaidoTōbetsu, Hokkaidō, Japan
Tohoku UniversityMiyagi, Japan
Hokkaido University
Sapporo, Hokkaidō, Japan
- Department of Internal Medicine


text:
Three-vehicle crash near Garfield causes serious injuries
A 32-year-old Garfield woman suffered serious injuries in a three-vehicle crash near Garfield this morning.
The crash happened at the intersection of County Roads 22 and 6 at about 7:15 a.m.
Amanda Warren was driving east on County Road 22 and making a left turn on to County Road 6 when a full-sized Dodge truck struck her vehicle from the rear, according to the Douglas County Sheriff's Office.
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subset: commoncrawl


text:
The Good
Jeff Lindsay, the writer of the Dexter novels, is bringing the serial killer and his dark passenger into the panels. If you're like me -- a fan of the show and haven't read a single novel -- then you need to know one key thing going into this: it's not based on the show. It's based on the novel.
This issue is pretty much everything you'd expect it to be. It's narrated by Dexter and does all of the basics to establish a new murder mystery in Miami. It's nothing out of the ordinary or shocking, but that isn't really a bad thing, either. It obviously strives to make you believe one key character is behind the killings and it would indeed make sense, but as of right now, we simply don't have all of the facts to point the finger just yet. Additionally, Lindsay does the bare basics establishing the supporting cast but ultimately (and understandably) shines the majority of the light on Dexter, a character who manages to deliver a constant flow of amusement through his thoughts.
One thing I really dug about this issue was the frequent inclusion of Dexter's dark passenger. It's lurking around him at all of the right moments, giving us a nice reminder that despite his somewhat relatable dialogue, we are indeed rooting for a man who always has murder on his mind.
The Bad
There's literally no disclaimer to inform you this is based on the novel and not the show. So, upon seeing Dexter for the first time and he looks nothing like Michael C. Hall, it was pretty jarring. Even though they're going for the novel's continuity, I would have thought they'd make him resemble the face of Dexter the masses have come to know? Having him look different and providing no introduction/disclaimer about the continuity is a very odd choice seeing as not everyone researches titles online before purchasing them and there are countless fans of the show who haven't read the books. If they randomly spot the cover on a stand and pick it up, they're sure to be confused, especially since it does use characters who were in the show as well.
One particularly odd thing is I found Dexter to be far more likable than Rita. Who would have thought that? Also, is it just me or did Dexter technically call Rita overweight when saying the "alien ray" is contagious?
The Verdict
For me, the biggest benefit of throwing Dexter Morgan into the panels is the fun they can have with the visuals and that's more than transparent with the creative and pleasing use of his dark passenger. As I said above, the book doesn't really do anything to blow you away or surprise you, but it's by no means bad, either. It's a pretty simple and formulaic intro and if you're a fan of the character, it's worth at least checking out.


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iVillage agrees to be Purchased by NBC
Did you see in the Business news that iVillage is about to be purchased by NBC? I wonder what changes that will bring to use here at Gardenweb if any. I read about it in the business section of the New York Times. I don't know if the link will work but I'll try to include it.
Here is a link that might be useful: iVillage purchase by NBC
Flooded??? You mean it can get worse?? Lately anytime I open a post, I get a video pop up. Whether it be the exploding pants (the least annoying of all), The crystal light, the honda one, and the South Beach Diet. Now it plays without even being seen, so I cant even click the X to make it stop. No I dont want any cheese with my whine. =)
I use Firefox and only see the occasional floating triangle.
Firefox has a pop-up blocker that will make your entire internet experience go much smoother.


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Print without images
Wednesday, June 9, 2010
BC's Larmond Jr. working to help whole offense
By ESPN.com staff
Boston College running back
Montel Harris
and wide receiver
Colin Larmond Jr
. were roommates last year and are good friends, which is why Larmond Jr. has no problem doing a little grunt work and blocking for the team's leading rusher.
Colin Larmond Jr. wants to be a leader on and off the field for Boston College.
There will be a lot of pressure on Harris to carry the running game since there's not a lot of depth behind him, so the Eagles' passing game will be needed to help draw some of the defensive attention elsewhere. Larmond Jr. is the team's top returning receiver, having averaged 20.5 yards on his 29 receptions last year, but his focus this offseason has been getting the edges covered and blocking the safety for Harris.
"We talk about it all the time," Larmond Jr. said. "… He knows we're trying to work out there for him. It's fine by me because I know if I make that block he can go the distance."
Larmond Jr. will also be expected to emerge as the go-to receiver. The Eagles will miss the production of Rich Gunnell, who finished his career as the BC record holder in receiving yards. The group also lost
Justin Jarvis
Clarence Megwa
to graduation. Larmond was second on the team with 29 catches, 596 yards, five touchdowns and a 45.8 yards per game average. He has shown big-play capabilities, as he had four of BC's five longest receptions of the year.
Billy Flutie
is the only senior of the group, so younger players like
Clyde Lee
Johnathan Coleman
will have to learn quickly. Flutie and
Ryan Lindsey
could also become key contributors.
Larmond said he's looking to add more variety to his game this fall, and be able to line up in different places, and be more diverse in his route running. His responsibilities will extend beyond the field, though.
"I have to be the leader of the group and make sure I tell the guys when adversity hits us to keep going, don't give up," Larmond said. "I have to help them out, answer questions when I can and lead by example. When things aren't going right, stay with it. Don't get all frustrated. Just mainly lead by example and try to bring up the other guys. They feed off my energy. Once I'm energetic and ready to go, then they get energetic and ready to go, then we're going to be a hard receiving corps to stop."


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Dendritic Salt has a greater surface area than other salts which means the fragrance (or essential) oils and color stick better and with more OOMPH! Many crafters add Dendritic Salt to their Sea Salt formulations for the non-clumping capabilities. But this isn't just any bath salt recipe…this is a baked bath salt recipe. This recipe bakes in the colorant and fragrance oil leaving a smooth, dry and clump free texture. People are going to ask you how you got such a nice consistency with such a fine salt.
This kit includes:
This kit is a little different than our other kits in that you can remove or get extra of each item in your shopping cart (and the price will adjust accordingly) before you check out. So you can just get what you need. Also please note that there are no printed instructions included with this kit, learn how to make these bath salts on the Soap Queen Blog here.
"Thank you for your prompt response. Bramble Berry has the best customer service of any company I know of. Pass the word!" -Rene
Kevin of Devinely Designed creates beautiful soap and shares his creations via his YouTube channel, Devinely Designed. With over 100 videos, Kevin has made a name for himself in the community for providing creative and educational soap making videos. From a Dandelion Zebra Swirl Tutorial to his first experience making liquid soap, Kevin's videos are fun and […]
The post Interview with Kevin of Devinely Designed appeared first on Soap Queen.


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Alternative Titles
English: Code Geass: Lelouch of the Rebellion R2
Synonyms: Code Geass: Hangyaku no Lelouch 2nd Season, Code Geass: Hangyaku no Lelouch Second Season
Japanese: コードギアス 反逆のルルーシュ 続編
Type: TV
Episodes: 25
Status: Finished Airing
Aired: Apr 6, 2008 to Sep 28, 2008
Producers: Sunrise, Bandai Visual, FUNimation EntertainmentL, Mainichi Broadcasting, Bandai EntertainmentL
Duration: 24 min. per episode
Rating: R - 17+ (violence & profanity)L represents licensing company
Score: 9.001 (scored by 263707 users)
Ranked: #102
Popularity: #13
Members: 363,775
Favorites: 24,766
1 indicates a weighted score
2 based on the top anime page.
My Info
Popular Tagsaction code geass drama mecha sci-fi supernatural


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Purple jersey snood
Item No.0250101660
Wrap up in this purple snood from the Mantaray collection. It comes in a soft jersey fabric and can be worn loose or doubled over.
This item is available for
UK Home Delivery Free (UK orders over £30) or £3.99
Delivered within 4 working days
Next or Named Day Delivery
7 days a week between 8am - 6pm
Monday to Friday - order by 7pm - £4.99
Saturday & Sunday - order by 6pm - £4.99
Next or Named Evening Delivery
7 days a week between 6pm - 10pm
Monday to Sunday - order by 10pm - £6.99
Collect from store the next day - FREE
Order before 7pm for next day collection after 12pm midday
Show participating stores
Full Delivery details
- 100% polyester
- Machine washable


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Veal And Zucchini
|Veal leg round steak/Beef round steak
|1 Pound, cut 1/4 inch thick
|All purpose flour
|2 Tablespoon
|Cooking oil
|1 Tablespoon
|4 Tablespoon
|Unpeeled zucchini
|8 Ounce (2 Pieces)
|4 Ounce (1 1/2 Cups)
|1 Clove (5 gm), halved
|Parsley sprigs
|4 , stems removed
|Dairy sour cream
|1 Cup (16 tbs)
|1⁄3 Cup (5.33 tbs)
|All purpose flour
|1 Tablespoon
|Dijon style mustard
|1 Tablespoon
|Dry sherry
|1 Tablespoon
|1⁄4 Teaspoon
Cut meat into four por-tions; pound with meat mallet to flatten slightly.
Coat with 2 tablespoons flour.
In 10-inch skillet brown meat, 2 pieces at a time, in hot oil.
Return aII meat to skillet; add water.
Reduce heat; cover and simmer for 15 minutes.
Meanwhile, place slicing disk in work bowl; slice zucchini and mushrooms.
Add to meat; simmer, covered, about 15 minutes longer or till meat is tender.
Transfer to platter; keep warm.
Place steel blade in work bowl; add garlic and parsley.
Process with on/off turns till finely chopped.
Add sour cream, milk, the 1 tablespoon flour, mustard, sherry, and salt.
Process just till mixed.
Pour into skillet; cook and stir over low heat till mixture starts to bubble.
Do not boil.
Spoon over meat and vegetables.


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Update: Helicopter being brought in for water drops to help control blaze in the Badlands near Medora
Firefighters are trying to contain a 25 to 30-acre fire about eight miles south of Medora in the Plumely Draw area, according to the U.S. Department of Agriculture Forest Service.
No structures or homes are threatened, an official says.
The fire is in a remote area, several officials said.
Get the full story
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You will need your subscription account number and phone number. Not sure if you have an account? Call (701) 225-8111 and we can help you.


text:
Jobs: High-Tech Ads Create Super Hand ModelsHow the advertising boom for iPods, Kindles, and other gadgets is creating a new kind of supermodel.
Economy: Should You Default On Your Debts?If billionaires don't feel guilty about walking away from their debts, should homeowners?
Tiger Woods: The Price of a Celebrity EndorsementHis comeback to the pro tour may prove easier than his return to the heights of celebrity endorsements.
U.S. Business-School Grads Seek Jobs AbroadFor new business-school graduates, the road to success no longer leads directly to Wall Street.
Environment: Turning Carbon Into Cash With OffsetsHow the carbon-offsets market is turning Wall Street traders and an African stove maker into unlikely business partners.
Retirement Savings: How Safe Is Your Nest Egg?The stock market's rebound may have you thinking you're once again ready for retirement. Think again.
Why Employment Will Rebound Faster Than You ThinkThe nattering nabobs of negativism are ignoring the facts.
Chinese See Environment As Biggest Security ThreatWhat does China see as its greatest threat? Beijing may finger the U.S., but a new poll of Chinese public opinion shows that people on the ground are more worried about the environment and domestic woes than geopolitical enemies.Conducted by the Lowy Institute for International Policy and the MacArthur Foundation, the study found that three quarters of Chinese pointed to environmental problems such as climate change as a major threat to China's security, while 67 percent cited water and food shortages, and 58 percent said internal separatists. Only half of respondents thought the U.S. posed a security threat, and 45 percent still worried about Japan (though the survey indicated that would change if Japan were to acquire nuclear weapons). The other big regional players—India, Russia, and South Korea—were seen as relatively negligible risks.Still, there is one area where foreign governments worry the Chinese: sovereign investment. Close to 80 percent opposed the idea of a Japanese...
Zakaria: A Global Economic Power ShiftWhy terrorism and economic turmoil won't keep the world down for long.
Biggs on the New NormalDon't run with the herd—ever.
High Unemployment is Here to StayShort-term prospects may be brightening, but high unemployment will be a fixture for the foreseeable future.
Globalization Slows DownIn November, I met with an executive at one of the private-equity firms that has sprung up in Beijing. He talked up the firm's investments in energy software and mobile communications. But exporters? He wouldn't touch them.The fact that China's smart money is now looking inward and avoiding the sector that brought it so much growth in recent years highlights a new trend that is likely to continue and spread next year. For the past few decades, goods, services, and people have been whizzing around the world at ever-greater speeds and over ever-greater distances. The presumption was that this was the most efficient way to organize the globe's economic affairs. But a backlash has set in, motivated by economics, politics, and the shift of wealth from West to East. As a result, it seems we are now experiencing a round of deglobalization.In the months after September 2008, pretty much every metric that testified to the growing interconnectedness of the global economy fell off a cliff. The...
Jobbed: Need a Job? Head to Washington, D.C.The increase in government jobs—courtesy of stimulus planning and spending—is turning Washington, D.C., into a boomtown.
A Business Idea With LegsLittleMissMatched's stores and Web site cater to fashion-forward tweens. But as the company grows, it's struggling to maintain its unique brand identity.
The November Jobs Report: Better Than It SeemedFour reasons that rosy November jobs report was even better than it seemed.
Will Healthcare Reform Bankrupt Us?Medical spending threatens everything else.
Forget Nursing Homes. Try a Retirement Commune.Can't cope with the idea of a nursing home? Consider a retirement commune.
Americans May Face Leaner Workplaces for YearsAmericans may see a leaner, meaner workplace for years to come.
Why Markets Overreacted to Dubai's Debt TroubleWhy the world overreacted to Dubai.
Christmas: Early Shopping Data Doesn't MatterThe early economic reports about holiday shopping are confusing, contradictory, and useless.
Need a Job? See a Small Business Owner.The president thinks small-business owners like me can turn the economy around. He may be right, but we're going to need a little help.
Jobs: Did Positive Thinking Kill Your Career?Author Barbara Ehrenreich on how unbridled economic optimism may have cost you your job.
Why Obama's Jobs Summit Won't MatterA presidential confab to create jobs won't work. Rethinking some of Obama's policies might.
Dubai: The Lehman Brothers of the Persian GulfDubai assumes it's too big to fail. We'll see about that.
Will Helping Your Kids Delay Your Retirement?How some parents and grandparents are delaying retirement to help kids out of financial straits.
Drill, Comrade, DrillBy Owen Matthews and Anna Nemtsova...
It's the Wrong Time to 'Reform' the FedGive the Fed its due.
Small Biz Makeover: Guayaki Tea's Big ChallengeTaking on Coke is no easy task. But the founders of a relatively small tea company think they've got a formula for success. All they need is a little help.
How Communist is Communist China?China is a Communist country, but I have yet to meet an actual Communist.
Shopping: Cyber Monday to Outdo Black FridayBlack Friday is old news. This year, the real retail boom will arrive on Cyber Monday.


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Epoxy Grout...specifically CEG-Lite
I only have grouted tile 3 times twice with cement based grout and yesterday with CEG-Lite epoxy grout.
Based on my experience I will never use cement based grout again. In my opinion/experience it is harder to mix and too easy to dilute the color during the clean-up phase.
The CEG-Lite grout that I used yesterday was basically fool proof. It is much easier to mix than cement based grout. I mixed it in the hallway outside of my bathroom with no dust or mess and in about 5-10 mins tops. The clean up does not get any easier, just use plenty of water and clean the surface of the tiles in a circular motion.
I ended up only using half of my first container because I was concerned about making sure I did it correctly. I actually ended up doing more than I had planned on with my first attempt with this product due to ppls claims that epoxy is hard to use and hardly having any experiences posted on CEG-Lite. Not sure how SpectraLock is but if it is easier than CEG-Lite then there is not much of an excuse not to be using epoxy based grouts on the bathroom or kitchen floors.
The end results is a very smooth kind of sheen/sparkle look, consistent color (which I never got from the cement based), and it is very hard.
The only negative I encountered was the surface of my tile ended up very sticky. I then got some hot water and some grout cleaner, then distributed water across the face of the tile, then poured some grout cleaner directly to the tile surface and scrubbed with the white scrubbing pad and then dried with a micro fiber towel. I was worried that this was going to be a big issue...nope cleaned it right up and this was performed about 6-hours after installing the grout. I dont think I could do that with cement based grout.
This stuff was ridiculously fool proof.
As a result I will be doing the tub surround with it as well.
Me as a home owner doing it myself am not concerned about the additional cost of the epoxy grout vs cement based. I am more concerned about the results. I am already saving money by not having someone come to my house and do the work. Why not spend more money on something that will continue to look good without having to seal.
DONT BE SCARE TO USE THE EPOXY...I ACTUALLY REGRET NOT USING THIS FIRST DUE TO ALL OF THE NEGATIVE EXPERIENCES POSTED...I am assuming that these products have come a long way and you can not base post from two years ago on what is available today.
I agree with you! I just had my bathroom done with 3 types of grout, chosen for their colors. The blue epoxy from Spectralock was the best looking and the easiest for the installer to apply as judged by me since he left no haze mess for me to clean up with it. It looks great. The color was consistent and dark.
The second best was the premixed tub grout from Tec Invision. We had him use this on the floor. The appearance is good but there was a haze that he left that had to be taken off with vinegar.
The absolute nightmare of the project was the cement grout on the river rocks for the tub surround. We chose cement for that because of the reviews for epoxy being hard to work with and I knew if grout was on the rocks it would be a nightmare to get off. Turns out the cement is a nightmare because it gets efflorescence and turns white if you use water to wash it off (there is no other way to get it off the rocks), it got in all the little crevices of the rocks and dried there a bright white because of the efflorescence. This was the hardest to fix. We had to hit the grout with two acid baths and scrubbing to get the efflorescence off and then apply an enhancing sealer. This left us with highly etched grout but fairly clean looking rocks. I think that cement grout should be taken off the market when there are such better alternatives like epoxy. I wish we had used epoxy for the whole project and in the future should we ever need to grout again (hopefully not) we will chose epoxy.
I should have included a picture. The epoxy is on the blue glass tile around the tub. The cement is on the river rock on the tub deck. The Tec Invision premixed is on the floor. We've got a few test paint colors up on the wall so ignore them.
Have you used Epoxy grout in a bright white color? We are doing a steam shower and need the best, whitest grout for a steam shower.
I used the CEG-Lite epoxy grout in a little 1/2 bath earlier this year. Talk about amazing color consistency. I used the black color and it was jet-black all the way through. It's also really tough once it dries.
It was easy to mix & install, IMO, and I didn't have the issues some people mentioned in the review, like it setting too fast. However, it was a beast to clean up the tile the next day when I went to buff everything. Just make sure you really scrub down the tiles *really* well before it dries!
I didn't take any close-ups, but here is the grout:


text: Stopped in for drinks while on the way back to my Hotel and was shocked to find that at 9 PM on a Thursday Night, the place was empty. No one, not one person at a table and only two people at the bar. The inside of the restaurant looked very nice and the bar area looked like a nice... read more


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John Baer, Daily News Political Columnist
Former Gov. Corbett, who tried but failed to trim public pensions for state workers and school employees, is pulling down a pretty good pension himself.
The Pittsburgh Tribune-Review reports Corbett took a lump-sum payment of $118,378 after leaving office in January and is getting an annual payment of $38,765.
The amount is based on Corbett's 11.3 years of state service: four as governor, six as attorney general and a year-plus as acting attorney general, appointed by Gov. Ridge after AG Ernie Preate went to prison.
John Baer, Daily News Political Columnist
If you need further proof that political discourse is declining at alarming rates, I refer you to a GQ profile of potential Republican presidential candidate Ben Carson.
It starts by quoting the conservative former neurosurgeon calling President Obama a "psychopath."
The quote comes from Carson's comments while watching the President deliver his State of the Union Address.
John Baer, Daily News Political Columnist
Well, you knew it had to happen.
You knew at some point somebody somewhere would actually push Joe Biden for president.
That time its now. Maybe because of Hillary's email mess. Maybe because Elizabeth Warren says she won't run. Whatever the reason, The Washington Post reports there's now a "Draft Joe Biden" super PAC and, yes, it means draft him for president.
John Baer, Daily News Political Columnist
If you're looking for a sense of how things are going in Harrisburg between the new Democratic Wolf administration and the Republican Legislature all you need to do is read the mail of any school superintendent in the state.
First, right after Wolf proposed new big spending for public education, GOP leaders fired off a missive to school districts essentially saying, yeah, well, don't count your chickens.
And Philly, as you know, is hoping for lots more chickens.
John Baer, Daily News Political Columnist
Ok, not that it's a real shocker, but the Pittsburgh Tribune-Review reports that the investigation of state Attorney General Kathleen Kane started with info passed along by former state prosecutors with whom she was, is and likely always will be at odds.
The Kane case involving her alleged leak of secret grand jury material related to a 2009 probe of former Philly NAACP boss Jerry Mondesire, which never resulted in charges against him, could result in criminal charges against the sitting AG.
The leak came to light after high-profile clashes between Kane and former state prosecutors Frank Fina and Marc Costanzo over the state's investigation of Jerry Sandusky and a sting case involving some Philly lawmakers and a former traffic judge.
John Baer, Daily News Political Columnist
Don't you just wonder?
Wouldn't you think when one pol, say former Democratic U.S. Rep. Anthony Weiner, is caught in a national embarrassment for sexting with a woman named Sydney Leathers, that other pols might say to themselves, "Boy, I'm never gonna do that."
Well, meet Democratic Indiana state Rep. Justin Moed.
(A brief discussion twixt Baer & Baer's editor, a/k/a BE)
JB: Chief, didya see that wonderful Inky report on mayoral candidates' tax returns?
BE: What's more fun than rooting around in pols' private lives?
John Baer, Daily News Political Columnist
Politics, as you may have noticed, can be somewhat fungible.
You know, in the sense that representing a blue-to-purple state such as Pennsylvania can require some wiggle room when it comes to hard-line issues.
That said, I couldn't help but notice a slight wiggle evident in ratings of Democratic Sen. Bob Casey and Republican Sen. Pat Toomey that are awarded annually by the Club for Growth, a national conservative powerhouse with lots of money and clout.


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In 1993, JSD started Bass Kittens to put out his own work. A string of 12" singles followed, along with the full-length CD Sweaty Planet.
He has released a full length drum and bass CD entitled Too Stoned To Sneeze Without Regretting It under the artist name Random.
Some artists he has worked with/produced/remixed: Hardkiss Brothers, Mark Pistel, Freaky Chakra, Single Cell Orchestra, Volsoc, Planet Eater, Mephisto Odyssey, DHS.
In 2000 he started Pretension Records with J Bondy & Justin Maxwell, with the aim of pushing West Coast electro.
He has written music for film (Black Eyed Dog), TV (Invader Zim), performed live in front of thousands of pornographers (2001 AVN Awards), and released several CDs of sample material through Sony Media Software.
Edited by [deleted user] on 7 Jul 2008, 20:55
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Batch counter: 109 batches (11/29/11-3/16/15).
With the IC I would pull hot wort from ball valve and return up to the top with 1/2" ID silicon hose. Place hose st edge of kettle such that it would create a whirlpool. I also started to stir with spoon inside of the IC to try and help. It was faster than not having the pump, but not what I was expecting at all. The dudadiesel plate chiller is a godsend.
As far as recirculating and BIAB, again pull from ball valve and return into camlock fitted into lid. (I don't believe in hot side aeration, and least that it doesn't affect our level of brewing).
At some point I would like to get a loc-line circle flow kit:
Picture from post here: http://www.homebrewtalk.com/f11/loc-...72/index2.html
Thanks! That looks ideal.
As far as decreased cooling times goes/taste improvements I'm still on the fence whether a pump is a worthy investment - $200 or so with fittings and tubing.
You could always do the no chill BIAB like the Aussie's. Can't get much easier and faster than that.
Thankfully I have never had an infected beer (some have been undrinkable, but not due to a wild yeast/bacteria infection), but that is the primary concern with not chilling fast enough. I'm sure there are other reasons like hop aroma's etc...
I didn't spend that much on my chugger pump, fittings and tubing. But I also went with aluminum fittings and got a great deal on ebay for the silicon hose.
Up until recently I controlled the flow out of the pump with a spring clamp not a ball valve. Very ghetto but constantly tweaking and upgrading. which is half the fun.


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Our latest list of the top 102 movie cars of all time includes some legends and some cars you may not have even heard of.
Edmunds put its right foot to the floor to test out the redesigned BMW X6 M hyper SUV.
We added an all-new 2015 Acura TLX SH-AWD to our long-term fleet to see if it has what it takes to replace not one, but two models in the company's lineup.
An early look at the all-new midsize SUV.
Ford overhauls its popular five-passenger crossover for the first time. We drive it.
Highlights of the half-ton pickup that you should see.
What's Hot on Edmunds.com brings you the latest car news, road tests, car reviews, photos and videos from our expert team of automotive editors.
Our car news section provides you with daily updates on the latest automotive news and industry stories, including vehicle pricing debuts, recalls and auto shows. Browse our car picture and video galleries for high-resolution photos of your favorite vehicles, track tests, video reviews, dyno tests, and more! You can find detailed car reviews on every make and model in production from our expert vehicle testers. In our Tips and Advice articles, you'll get helpful guidance on a variety of topics such as car buying & selling, auto financing, driving tips, maintenance and car safety. Bookmark this page and check back daily for updates!


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Turning Cold Cases Into Solved Cases
Updated: 06/15/2005 - More than a dozen murders have gone unsolved in Leon County and Tallahassee in the past 25 years.
Updated: 06/15/2005 - More than a dozen murders have gone unsolved in Leon County and Tallahassee in the past 25 years.
Updated: 06/15/2005 - A preliminary investigation into the hacking of a computer system at Valdosta State University is finished.
Updated: 06/15/2005 - A group of fishermen rides along with biologists to prove to them that new fishing nets are deadly to certain fish species.
Updated: 06/15/2005 - A man is being held in jail on charges that he sexually assaulted a seven-year-old child.
Updated: 06/15/2005 - Georgia's governor says litter is too much of a problem along Peach State roads, and something has to be done. The problem hits close to home.
Updated: 06/15/2005 - The state of Gadsden County's health has been a big topic among local leaders for some time. Florida Health Secretary John Agwunobi paid a visit to the county to commend those who've tried to address the county's health concerns head-on.
Updated: 06/15/2005 - Hundreds of thousands of children go hungry in the summer because they're not able to take advantage of the free or reduced lunches offered during the school year. A new law aims to make sure those youngsters get at least one nutritious meal every day.
Updated: 06/15/2005 - Update your spice rack.
Updated: 06/15/2005 - This month some of the area's brightest students are putting their skills to the test.
Updated: 06/15/2005 - It was a breathtaking day for sports fans all over the area.
Updated: 06/14/2005 - The recent rains are causing major headaches for people in one south Georgia neighborhood.
Updated: 06/14/2005 - A billion dollar coal-fired power plant needs a home, and residents are saying, "not in our backyard."
Updated: 06/14/2005 - Find out what the red, white and blue means to people in Tallahassee.
Updated: 06/14/2005 - Georgia state senators are turning their attention to courthouse security. Several senators met with south Georgia leaders to discuss the best solutions.
Updated: 06/14/2005 - Florida State starting quarterback Wyatt Sexton is in hot water as he's pepper sprayed by police and taken to a psychiatric center.
Updated: 06/14/2005 - Florida's community colleges are urging Gov. Jeb Bush to veto a bill that would jack up tuition rates for more than half their students.
Updated: 06/14/2005 - Coach Joe was fired for a violation of NCAA rules.
Updated: 05/02/2007 - Surveillance video catches of a bank robber who forced an elementary school to be put under lockdown.
Updated: 06/13/2005 - Young people in the area are facing another difficult summer job market.
Updated: 06/13/2005 - The search is on for yet another Valdosta bank robber. It's the third bank robbery in the past month. Investigators need your help in tracking down the robber.
Updated: 06/13/2005 - A weekend home invasion leaves an unborn child dead and a family mourning, but Thomasville Police, with the help of the Georgia Bureau of Investigation and the Thomas County Sheriff's Department, say they have their men.
Updated: 06/13/2005 - Graves are found on the plot of land where Gadsden County wants to build a new high school.
Updated: 06/13/2005 - A bank robber wrestles with his conscience all weekend and ultimately decides to surrender.
Updated: 06/13/2005 - If a French menu looks Greek to you, Mr. Food is here to translate for your culinary cuisine.
Updated: 06/13/2005 - A jury acquitted Michael Jackson on Monday of molesting a 13-year-old cancer survivor at his Neverland ranch, vindicating the pop star who insisted he was the victim of mother-and-son con artists and a prosecutor with a vendetta.


text:
Council approves transfer agreement with police sergeant
WORTHINGTON — In a meeting with few items on the agenda Monday night, the Worthington City Council approved a resolution for transfer agreement between a police sergeant and the Law Enforcement Labor Services Local No. 274 and 4.
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As they say, the first impression is the last impression and it applies more on cars. If a car is designed well, it's surely going to attract more... ...http://www.cartrade.com/blog/2015/top-10/top-10-best-looking-cars-in-the-market-1255.html
Skoda Octavia vRS India launch on hold Skoda's sporty version of the Octavia has been sold in India for the past two generations. Whereas the... ...http://www.thehindu.com/features/metroplus/Motoring/gear-up-news-of-new-vehicles/article7032448.ece?utm_source=RSS_Feed&utm_medium=RSS&utm_campaign=RSS_Syndication
Volvo has embarked on an expansion plan that will see the luxury car maker launch three new models in the Indian market this year. The first in... ...http://www.autox.in/news/car-news/three-new-volvos-to-hit-the-indian-road-in-2015/
Volvo has revealed a 2,000-car sales target in the country for 2015, after achieving sales of 1,200 cars in 2014. "We have embarked on a... ...http://www.drivespark.com/four-wheelers/2015/volvo-reveals-2015-india-sales-target-of-2000-cars-010158.html
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I love dogs
This great custom product in deep heather from our department Women and T-Shirt category can be printed just for you in the size and style you like. The design I love dogs was created by Bubbagom and uploaded to Spreadshirt for you to have printed on a T-Shirt. Next to a host of other great customized designs, you can find this I love dogs design in Spreadshirt's Dogs category. If you are interested in topics like Dog or heart, then you'll love I love dogs designs by Bubbagom. Spreadshirt also offers a huge selection of custom t-shirts, hoodies and accessories for the category Dogs as well as top love clothing. Bubbagom's designs have already impressed many of our customers, so we are sure that we've got right stuff for you! Spreadshirt is your destination for great designs of all kinds – whether it's Dog, heart or love. We are sure that you will find something nice in our shop, there are many amazing custom Dogs t-shirts, hoodies, or accessories for you to find! Tags: Design ID: 2813420
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This relaxed fit classic offers plenty of room and is ideal for most body types. Perfect as an outer or under layer, this versatile t-shirt is a must-have for all wardrobes.
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#MCGsobig but the Garden of Eden bigger still. Has no trouble repeatedly fitting 4.4 million Kiwis inside. #RWC2011 #CWC15 #Sportimentalism


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Is your guitar a pain in the neck? You need Mega comfort.
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Inspired by classic guitar amp fabrics! Pick pocket with free pick. Adjusts from 35" to 59-1/2". 2" wide.
A great design by the leading manufacturer of consumer leather and nylon goods.
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The GS1 Doolittle Guitar Strap is made of 2" wide reinforced woven cotton that is designed to conform to your...
Comfortable elastic strap has leather ends and adjusts from 32" to 56.5".
Have you ever started setting up for a gig only to realize that you forgot to bring your guitar strap? It's a situation that really hammers home how important the strap can be, even if it's not always at the top of our minds when we think about guitar accessories. In the family of gear dominated by such iconic fixtures as amplifiers and effects pedals, the guitar strap is a humble, but just as essential, member.The strap is also a big part of your overall personality on stage. There are plenty of colors, patterns, embossing and images to choose from, so you can have a look that's perfect for you. With everything from burned-in patterns on leather to edgy metal studs to all-out graphic artwork, you can find the right match for your band's image and the style of music you play, as well as your own personal preferences.You've also got a lot of options when it comes to material. Leather is the tried-and-true classic, especially for country and folk music. There's also suede for a similar appearance with extra style. If you want a vintage rock or pop look, check out some tweed or cotton straps. Or go in a modern direction with poly or nylon, which make for lightweight, flexible and durable straps. You can even get vinyl or velvet to really make a statement—it's all about the impression you want to make.Whatever style you're considering, make sure to keep an eye on the length adjustment range to be certain the strap will be a good fit for you. For example, if you're a tall player who likes the guitar at arm's length, you'll need a strap that's long enough to reach. On the other hand, if you have a smaller build or you like to get up close and personal with the instrument worn high, a shorter strap will go the distance without having a whole lot of extra length to get in your way.One final thing to consider would be whether the strap has any padding. If you play long gigs, especially with heavier or even double-necked guitars, a strap with a wide bolstered shoulder or memory foam pad will help save you from that all-too-familiar feeling of waking up with a sore shoulder. You can even get a dual-shoulder strap to distribute the weight of a beefy instrument.Above all, the strap is like just about everything else on a guitarist's shopping list: a personal choice that only you can make. A guitar strap with the look and feel you want is not only a practical way to hold your instrument during the performance—it's also an important part of your stage presence.
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CNAM is an acronym which stands for Caller ID Name.
When phone calls are made, there are usually two user-facing identifiable pieces of information: a phone number and a Caller ID Name (usually a 15-character string). CNAM can be used to display the calling party's name alongside the phone number, to help users easily identify a caller.
There are numerous CNAM lookup services which allow you to pay a small fee to lookup the CNAM of a specified caller (by phone number).
CNAM Lookup Services List:
http://www.bulkcnam.com/ Cost: Only $0.005 per query for carriers or $0.009 for hobbyists! No catch, guaranteed with easy paypal integration. Sign Up for a FREE Account and we will credit you 30 FREE CNAM queries to try http://www.bulkcnam.com/.
http://www.calleridservice.com No monthly fees or account minimums and 20 free queries to test our service when you open an account ( instant setup ). Simple HTTP API or Fast AGI that can be placed in your Asterisk dial plan. Also native support for Switchvox PBX systems. Results are never cached so you get up to the minute real-time results. Retail prices are $.006 per query and bulk pricing is available with a volume commitment of at least 25,000 queries per month. Free support and installation assistance is available.
www.callwithus.com offers both CNAM ($0.006) and LRN ($0.0003) look ups. No minimums and monthly charges. Simple HTTP API, easy to integrate to Asterisk dial plan.
CID(name) Professional CNAM (Caller name) delivery
- EVERY LOOKUP IS LIVE FROM THE SS7 (direct from the carrier owning the number)
- NO 3rd party data sources
- NO monthly fees
- NEVER pay full price for unavailable results
- Carrier grade, multi-redundant platform
- Simple to integrate HTTP API
- 99.7% caller id name accuracy
- Lightning fast query responses (under 500ms)
- Volume pricing as low as $0.002 per query
- Try before you buy, 100 free dips with every new account
- You choose the output, TEXT/JSON/XML
- Track sub-accounts
- Easy integration with Freeswitch, Asterisk, OpenSIPS, and other open source voip platforms
- Easy access and daily downloads to your account activity
- Thousands of happy customers
Get CARRIER GRADE CNAM at http://www.cidname.com
www.cnam.info offers both CNAM and a pseudo-CNAM service at a fraction of the cost. Integration with asterisk is as easy as downloading the AGI and adding a single line to your dial plan.
http://www.data24-7.com CNAM service for $12 per month (membership fee) and $0.005 per query ($0.004 for over 500,000 transactions per month). Simple HTTPS/XML-based API with examples, plus batch file upload and manual entry available via website. Asterisk support. We also support SIP protocol so your switch/dialer can communicate with our service directly. Members have full access to Data24-7's other services, such as carrier lookups and email-to-SMS gateway address lookups. Free trial!
http://www.multitel.net/ We have multiple SS7 interconnects and are able to provide you with some of the most accurate and up to date results. Pricing is $0.004 per query for our Free tier and it goes to $0.003USD and $0.0025USD for our Standard and Professional tiers. We do provide free testing - limited to 60 queries per hour. No commitment , no hassle. We are prepaid so you'll never have a surprise at the end of the month. You can access our services via SOAP or via JSON . We are also providing US/Canada/Australian numbers with CNAM enabled (each inbound call queries our CNAM database and will provide the name of the caller)
https://www.opencnam.com/ OpenCNAM - A simple Caller ID API
- Free tier which allows you to do 60 queries per hour for no charge (no signup required!).
- Professional Tier does exclusively real-time CNAM lookups (no caching).
- Starting rates at $0.004 per query.
- Volume rates as low at $0.002 per query! Extremely competitive volume pricing.
- Instant setup, no verification required.
- Payment accepted via Credit and Debit cards, and Bitcoin.
- You can choose the output format: JSON, JSONP (great for browser apps), XML, YAML, plain text, and PBX (a special format for integration with PBXs like Asterisk and Freeswitch).
- Excellent support, we'll help you get setup and running in no time, shoot us an email if you have any issues: email@example.com
- Enterprise contracts available for large customers.
Our goal is to make CNAM suck less. Join the cause!
thinQ A revolutionary game-changing service. Servicing over 650 Facility Based Carriers in the US, thinQ has an extensive CLEC network with buying power to back it up, powering the telephony market with services such as CNAM, LRN, and SIP Based Routing.
http://www.reverseaustralia.com/developer/ - offers free lookups and spam caller information for Australian numbers.
lookup_gotname() {
out=`/usr/bin/curl -s -m 2 -A Mozilla/4.0 http://cnam.got-name.com/?auth=<USERNAME>:<PASSWORD>\&type=http\&number=${1}`
echo $out;
lookup_order="sqlite3 anywho gotname google nanpa"
lu_name=`lookup_411 "${2}"`
lu_name=`lookup_gotname "${2}"`
lu_name=`lookup_google "${2}"`
An optional change: I (netplex/andrew) changed the lookup to not return the "NO AUTH" message because I wanted it to continue with other methods:
lookup_gotname () {
out=`/usr/bin/curl -s -m 2 -A Mozilla/4.0 http://cnam.got-name.com/?auth=USERNAME:PASSWORD\&type=http\&number=${1}`
if [ "${out}" = "NO AUTH" ] ; then
echo $out
Commercial Blurb put in by Rehan:
CNAM is the caller ID on a call that is sent from a wholesale carrier.
The company that own's that DID number gets the INTERCONNECT income because it owns the number.
Companies who provide calling card and call centers don't care what is the caller ID (what is sent to the CUSTOMER when a call is made). Because of the non-concern, they can use a DID number from a carrier that is willing to share its CABS income. This way they make MORE MONEY and get some money back which they currently pay to the termination company.
For example, say you make a call using the calling card, but when your call goes through, the number will appear 1-212-6552222.
You being the calling card company or any other company has a lot of outgoing traffic.
Companies that share CNAM revenue:
- DipFee.com If your company is doing over 400,000 calls per month please feel free to contact us and see if we can help you save about 10% of your calling costs.
- StarcomPartners.com When you join Star Communication's CNAM Program, you can instantly add a monthly revenue stream to your business without changing your current telecom provider or day to day operations. Large Companies and organizations that make a large volume of outbound calls can benefit from our CNAM revenue program through revenue sharing. Many Telephone companies pay a small fee to the caller ID database providers each time they retrieve caller ID with name information for the end user. Minimum of 250,000 calls per month.
Companies that share Cabs revenue:
- CallerID4u.com Calling Name (CNAM) Ready phone numbers are provisioned to receive "Calling Name" fees from a receiving carrier each time a call terminates on their platform. When this happens, Callerid4u's Caller-ID name is retrieved and matched to a nationwide Caller ID database. These small fees are aggregated into monthly payments from which Callerid4u then pays you.
- DIDX.org provides its wholesale members with DID's that pay up to .002 cent a min for sending the CABS. If you have 10,000,00+ terminating mins a month, DIDX can get this money to your pocket.
- DipFees.com shares CNAM dip revenue, minimum U.S. termination of 400k calls / month. Customers have control over caller name and incoming calls can be picked up via sip.
- ViaTalk White now provides an API for CNAM lookup. Haven't used it yet, but I've had decent luck with ViaTalk's other tools.
See Also
Please update this page with new information, just login and click on the "Edit" or "Discussion" tab. Get a free login here: Register Thanks! - Find us on Google+
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Hair Loss Sign Of HIV Infection
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
Hair LossHi there myself and my girlfriend are both infected with HIV my girlfriend is in receipt of treatment I am not yet. Her hair has been falling out slowly for more than a year, but now it's falling at a rapid rate, strangely my hair is no falling out...
Response from Keith Henry, M.D.
University of Minnesota, School of Medicine...individuals (indinavir and lamivudine are the ones I have noted). In my experience I can't make any sweeping generalizations about hair loss and HIV status other than AIDS patients in the pre-effective therapy days often noted increased hair... Read more »
why hair lossHi my problem is weird. About a month ago my hair started falling out in clumps. I am female and... Read more »
Hair Loss and HIV?Hi Dr. Young,I'm wondering if hair loss is a common symptom of ongoing HIV infection? I have been... Read more »
Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents...vaccination directly prevent pathogen-specific morbidity and mortality, they might also contribute to reduced rate of progression of HIV disease. For instance, randomized trials using trimethoprim-sulfamethoxazole (TMP-SMX) have documented that... Read more »
Treating Opportunistic Infections Among HIV-Infected Adults and Adolescents...Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997;277:112-6. 9. Connick E, Lederman MM, Kotsin BL et al. Immune reconstitution in the first... Read more »
U.S. Updates Clinical Guidelines for Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children...HIV-infected children and childrenwho were HIV-exposed through birth to an HIV-infected mother." Dr. Mofenson said. In recent years, HIV infection has increased among adolescents. "We hope that doctors and clinicians make use of these new... Read more »
Hepatitis C Virus Infections Among HIV-Infected Men Who Have Sex With Men: An Expanding Epidemic...of 28 co-infected MSM (25 percent). Of the 28 co-infected men, only five reported any history of injection drug use (IDU). HIV infection, IDU, fisting, and use of gamma hydroxyl butyrate (GHB) were found to be significantly associated with HCV... Read more »
Connect With Others
hair loss
Posted by mistake1, 1 Reply...does anyone know if hair loss is an hiv symptom and itchy skin also? Read more »
Hair Loss
Posted by Anonymous, 2 Replies...I was just reading a question to Dr. Henry about hair loss and Crixivan. I'm on Crixivan, Epivir and AZT. I've been on this regimen since the advent of protease inhibitors. Early on Read more »
hair loss
Posted by Anonymous, 1 Reply...would hair loss be normal for an infected individual...i am sure someone will just say it's stress Read more »
hair loss?
Posted by Anonymous, 3 RepliesIn the last year I have lost alot of my hair, has anyone else experience this as a problem or is it from something other than HIV? Read more »
Resource Centers
Guides for People With HIV


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Mobile, mobile-only, mobile apps, smartphones: Enough said
The newly released annual look at the digital world from online and mobile measurement firm comScore makes it quite clear that retailers better be ...
Mobile, mobile-only, mobile apps, smartphones: Enough said
The newly released annual look at the digital world from online and mobile measurement firm comScore makes it quite clear that retailers better be ...
Data breaches hurt more than e-retailers' bottom lines
Money matters, but online merchants must keep consumers' trust and offer reassurances that their payment data is secure.
Sign up for IRNewsLink and get daily reports delivery to your inbox. Sign Up Now
Sponsored by 2013 Social Media 300
Steelhouse enables e-retailers to customize offers based on online shopping behavior.
Online marketing and personalization firm SteelHouse has secured $6.3 million in the company's second round of funding.
SteelHouse's technology enables retailers to present online shoppers with personalized, offers based on buying behavior and shopping history, along with targeted ads presented after shoppers leave retailer sites. Clients include Canada-based flash sale site Beyond the Rack, No. 191 in Internet Retailer's Top 500 Guide; Cooking.com Inc., No. 188; and Musician's Friend Inc., No. 44.
Greycroft Partners, Rincon Venture Partners and Lighthouse Venture Group led the funding round.
"SteelHouse's personality-powered, Behavioral Commerce platform is finding an eager audience of online retailers that need to connect with shoppers more deeply and faster than ever before," says Dana Settle of Greycroft. "SteelHouse makes innovative leaps further and faster than anyone in this space, and that ability compels e-commerce sites to use SteelHouse's solutions to stay ahead of the competition."
SteelHouse plans to use the funds to develop its technology. "The next 12 months will be the most exciting year in our company's history," says Mark Douglas, SteelHouse's CEO.
Training, signage and motivation are all critical elements to making in-store pickup work. If done ...
Posted 03/13/15
With holiday promotions starting as early as September, now is the time to assess the ...
Posted 03/12/15
If there's something you've bought offline that you weren't able to buy online, we're probably thinking about that."


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ACE Fit Share
Add these shoulder exercises into your regular workout routine and increase your upper body strength, while strengthening and stabilizing your shoulders. From the stability ball dumbbell press to the medicine ball push-up, these exercises are a great way to strengthen your deltoids, rotator cuff and trapezius muscles. Browse through our large collection of detailed tutorials and step-by-step demonstrations from today's leaders in the health fitness industry. For full workout routines featuring these shoulder exercises, visit our Workouts section.
Fit Life Articles
There's no question—eating healthfully can be a huge challenge, especially when foods that seem healthy actually turn out to be potentially hazardous. The Nutrition Twins discuss four foods that were once promoted as healthy alternatives, but are now known to have hidden...
Are you ready for Sunday's Super Bowl kick-off? Typically one of the most indulgent days of the year, it is possible to stay on track with your fitness plan. ACE Exercise Physiologist Jacque Ratliff created a super-fun game-time workout that will help you keep moving...
Are you just getting started with a fitness routine and feel unsure about how to train your core? Try these introductory core movements for beginners—once you've mastered these exercises you can continue with more challenging options that will not only strengthen your core,...
ACE Pro Homepage
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Brooklyn Nets
Jason Kidd Set To Be Introduced As Brooklyn Nets Head Coach
Hello, Brooklyn. The Nets will introduce Kidd as their new head coach on Thursday at a 2 p.m. press conference at Barclays Center.
Brian Shaw In Mix, But Jason Kidd Owns Buzz In Nets' Coaching Decision
Kidd met with general manager Billy King on Monday and Shaw is expected to meet with the team Wednesday.
Report: Interest 'Mutual' Between Jason Kidd, Brooklyn Nets
Brooklyn's coaching search is "strongly pointing toward" Kidd after his meeting with team brass, the Post reported, adding that he's "viewed as the leading candidate for the job."
Jason Kidd Plans To Meet With Nets About Coaching Vacancy
Kidd is interested in Brooklyn' coaching position and plans to talk to the team this week, a person familiar with the situation told The Associated Press on Sunday.
Report: Nets Contact Hall Of Famer Larry Brown As Search For Coach Continues
The Nets are continuing to search for their next head coach, and it's no secret that owner Mikhail Prokhorov likes big names. Cue Larry Brown, the current head men's basketball coach at Southern Methodist University.
Williams' 11 Threes, 42 points Lead Nets Past Wizards
Deron Williams made an NBA-record nine 3-pointers in the first half, finished with 11 and scored a season-high 42 points to lead the Brooklyn Nets to a 95-78 victory over the Washington Wizards on Friday night.
Wizards Collapse Down Stretch, Fall To 4-27
Joe Johnson's jumper with 0.7 seconds left in the second overtime lifted the Brooklyn Nets to a 115-113 victory over the Washington Wizards on Friday night.


text:
Company Overview of Sumitomo Mitsui Banking Corporation
Company Overview
1-1-2, Marunouchi
Tokyo, 100-0005
Founded in 1876
48,824 Employees
81 3 3282 8111
Key Executives for Sumitomo Mitsui Banking Corporation
Sumitomo Mitsui Banking Corporation Key Developments
Mizuho Financial Group Inc. and Sumitomo Mitsui Banking Corp. effectively concluded their annual shunto negotiations with the labor side by agreeing to implement a 1.5% pay scale hike. The two will carry out a salary scale increase for the second consecutive year. The margin will be bigger than the previous year's 0.5%. A pay scale rise of 1.5% roughly translates into an increase of JPY 7,000 in the monthly salaries at Japanese megabanks, including Mizuho and Sumitomo Mitsui. Mizuho and Sumitomo Mitsui also agreed to raise bonuses by 3% from the previous year as demanded by their labor unions. At both banks, bonuses will increase for the third consecutive year.
Sumitomo Mitsui Banking Corporation announced the resignation of Hiroshi Minoura as Vice Chairman of the Board of the company.
Sumitomo Mitsui Banking Corporation announced appointment of Ken Kubo as director, effective April 1, 2015. Ken Kubo is currently working as Director (Representative Director) of Sumitomo Mitsui Financial Group Inc. and Deputy President (Representative Director) of Sumitomo Mitsui Banking Corporation.
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To contact Sumitomo Mitsui Banking Corporation, please visit www.smbc.co.jp. Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at email@example.com.


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The Book Show
9:14 am
Wed May 24, 2006
The Book Show #932
Albany, NY – Jodi Picoult, author of "My Sister's Keeper" and "Vanishing Acts," comes onto The Book Show to discuss her newest novel "The Tenth Circle." It tells the story of the Stone family, which is rocked when Trixie Stone, daughter of Daniel and Laura, is date-raped. Daniel finds himself facing an angry part of himself he thought long gone, and Laura must deal with her guilt over being with her lover when her daughter needed her. Picoult discusses the research done for the novel and the book's unique nature as a novel-comic hybrid.


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61955 is utilized for post office box purposes only in approximate location displayed above. No relevant statistics are associated with this ZIP Code.
|For Sale: 1
|New: 1
|Recently Sold: N/A
|Reduced: N/A
|Average Home Price
|Average Sold Price
|Property Records: 4
|Foreclosed: N/A
The average home price in 61955 is $174,000. The average home price per square foot in 61955 is $94 and about 0% of all homes in 61955 sold in the last 6 months. For 61955 home values, real estate prices, and city market trends, research the 4 property records or search our 0 recently sold or 1 homes for sale listings. The listings and properties in 61955 are only a part of the 3,891,486 properties and 83,165 homes for sale in Illinois. Because of this, the average home price and average home value of 61955 also influence the average home price $153,439 and average sale price $232,042 of Illinois. Listing counts, 61955 home prices and home values in 61955 are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.


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You are a fan of forun best ? Come to discover the best forums forun best on the internet and share your experience with a community fan of forun best . You can also build a forum forun best and create your online discussion.
Ip : 167. 114. 104. 134: 22393 (Main Server)
[tdc], #forun, totally, drivers, club, server, mta:sa


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So I'm fairly new to the home brew scene...I've got a London Porter recipe and I am wanting to turn this into a milk chocolate porter or a chocolate coffee porter. Any suggestions on how to achieve this? Thanks for the help
For the chocolate, search for cocoa/cocoa nibs. There is a ton of documentation and it is a "touchy" subject, so I will refrain from offering any opinions there.
For the "milk" part, I would add a pound of lactose and a half-pound of flaked oats.
For coffee, I would add a cup or two of really strong and good coffee. Like a sumatra.


text:
Property is in demand due to reduced inventory, as there are more potential buyers than sellers. Bidding wars with other buyers are possible, and listings begin to sell at greater than the asking price.
Rent prices are relatively stable, and availability is good. If your yearly income is around $35,000, you can afford to rent in this market. Rent prices have increased by 21% over the past 3 months. This is 104% lower than the state average of $1,208 and 296% lower than the country average of $2,350.
Trend data coming soon.
|For Sale: 146
|New: 14
|Recently Sold: 42
|Reduced: 41
|Average Home Price
|Average Sold Price
|Property Records: 5,583
|Foreclosed: N/A
The average home price in 27203 is $158,255, which is 59% higher than the average sold price in 27203 ($99,536) . The average home price per square foot in 27203 is $54 and about 1% of all homes in 27203 sold in the last 6 months. For 27203 home values, real estate prices, and city market trends, research the 5,583 property records or search our 42 recently sold or 146 homes for sale listings. The listings and properties in 27203 are only a part of the 3,391,175 properties and 80,918 homes for sale in North Carolina. Because of this, the average home price and average home value of 27203 also influence the average home price $195,184 and average sale price $228,155 of North Carolina. Listing counts, 27203 home prices and home values in 27203 are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.
|Median Age
|Median Household Income