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Saturday, 3 January 2015
Apple introduces new 14 Day Return Policy in EU iTunes/App Store
The App Store/iTunes is an amazing place for exploring new apps or discovering a new genre in music. But whenever I decide to scroll through both of these stores I take a few things into consideration such as price, quality and practicality. That method usually works well, but at certain times it goes straight out the window and I buy something impulsively. Momentarily later I realize that buying the game which was worth $5,99 or the album which sounded pretty good during the preview and cost twenty bucks was a huge mistake. My mind begins to think of all of the other things I could have bought and how it was stupid of me not to apply my three golden rules. If you have ever been in a similar situation well then you're going to be happy to hear that Apple is implementing a 14-day refund policy. In the European Union that is.
According to iFun.de, Apple have introduced a new 14-day return policy in order to meet the European Union consumer rights policies. But hold on, you can't just buy a game or an eBook and ask for a refund after you complete the game or finish the book. If you want your request for a refund to come through you have to have a discussion with Apple support explaining to them why you feel you deserve a refund and based upon the information given they will then decided whether to accept it or deny it.
Let me know in the comments below people if this is something which you may consider availing of in the future.
Thanks for checking this post out and if you like what you have read here make sure to click that share/+1 button and you can also follow me on Twitter for the latest game and tech news and news regarding the site.
Twitter: WordLoops
Sources: 9to5mac
: iFUN.de
PlayStation Apologizes For Hacking Incident
With the month of December still slowly wearing off it seems like the guys over at PlayStation are finally in the clear. December was a pretty rough month for both parties of the PlayStation community, the employees but most importantly the gamers.
On the 25th of December disaster struck the homes of thousands of players across the globe who were anxious to try out their brand new PlayStation 4 systems, when an unknown hacker gained access to the PlayStation's online platform the PlayStation Network. Players who unwrapped games such as Destiny or Advanced Warfare were devastated when they found out that they were unable to log in to their long awaited console.
The guys over at PlayStation are fully aware that the incident brought those Christmas smiles upside down and they're willing to make it right. PlayStation is extending the duration of existing sale offers which were on the PlayStation store and they're up there right now so check them out. PlayStation is also adding an additional 5 days to everyone's PlayStation plus subscription as a form of I'm sorry. On top of all that players will also receive a 10 percent off coupon sometime throughout the month. This coupon can be used on an item of the player's choice in the PlayStation store. (Go on a shopping spree people, go nuts.)
Overall it's nice to see that the guys over at PlayStation are focused on putting the whole incident behind them and they're hoping you will too.
Thanks for checking this post out people and make sure to click that share/+1 button if you like what you have read here. Also if you want regular updates about the latest games and tech follow me on Twitter.
Source: PlayStation Blog
Thursday, 1 January 2015
What Games am I Excited for in 2015
Now that 2014 is officially over, lets make way for the contenders for the "2015 Game of the Year Award". Seeing last year's awards night, 2015 seems pretty promising when it comes to solid and original game releases. I felt like 2014 was one big recycling campaign with all of the remastered games hitting the PlayStation 4 and the Xbox one consoles. I'm not saying that 2014 was a total flop but it was definitely lacking originality and excitement, something which I haven't seen in a while now.
Right now I'm going to go through the games which I am most excited for being released in 2015 and the ones which I will definitely be picking up throughout the course of the year.
Dying Light:
"Dying light" is an open world zombie survival game which offers various quests apart from the obvious one. Survive. The game is being made by Techland, a company based in Poland which is known for producing games such as "Dead Island and Dead Island: Riptide. If you have either played "Dead Island" or "Mirror's Edge" and enjoyed it, well then this is a game which you should consider picking up. "Dying Light's" main protagonist has to fight through hoards of zombies by creating makeshift weapons out of household items which are sure to get the job done. Only this time you don't have to worry about running into a dead end and being totally screwed, because the protagonist is also a free runner. "Dying Light" is set to be released on the 27 January 2015 for the PS4, Xbox One and PC.
Metal Gear Solid V: The Phantom Pain
The "Metal Gear Solid" franchise is considered as one of the most famous and successful franchises in the video game industry, and to be completely honest with you, I haven't played a single Metal Gear game in my life. The reason why I have yet to play Metal Gear Solid is there was always another game which got my attention. But at this years Las Vegas event something was different. Phantom Pain's graphics looked absolutely stunning and as the online demo progressed I found myself amazed by the weapons, gadgets and the numerous ways of executing an enemy whilst in stealth mode. The game is set to be released sometime in 2015 but the official date has yet to be announced. The game will be available on the PS4, Xbox One and PC.
Minecraft: Story Mode
"Minecraft" has always been known as the game which allows players to get as creative as much as they want. But for those of you out there who need a small push in order to get those creative juices flowing you might want to listen up. "Telltale Games" the crowd who are responsible for games such as "The Walking Dead and "The Wolf Among Us" have decided to undertake the task of bringing narrative content to the open world game. We haven't seen any footage of the game yet but I'm really anxious to know how this one is going to turn out. The game will be released as an episodic series more than likely on the PlayStation 4, Xbox One and the PC. The game has not yet received a release date but I do know that it's sometime in 2015.
No Man's Sky
"No Man's Sky" is the definition of originality and it's the type of game which is pushing the industry forward. For those of you out there who are unfamiliar with the game, No Man's Sky is an open world space simulator which allows for you to create your own planet as well as fly your very own space ship to other planets created by players around the world. The game looks pretty impressive and the fact that it was made by a small indie team even makes it more extraordinary. The game made it's debut at the "2014 Game Awards" and the hype was real people. But can it deliver? The game is set to be released sometime in 2015 and will be available on the PC and PlayStation 4.
It seems like 2015 is going to be a pretty exciting year for the video game industry. The games above were the ones which I am currently most excited about and let me know in the comments below which games you're most looking forward to in 2015. Follow me on Twitter for the latest game and tech news and if you like what you have read here make sure to click that share/+1 button.
Wednesday, 10 December 2014
Pick A Game With This PlayStation 4 Bundle
With this bundle you still get a 500 GB PS4 but instead of a specified game you will get a voucher for which you can then use to redeem one digital copy of a game of your choice. Some of the games which are eligible for download are LittleBigPlanet 3, Destiny, Far Cry 4 and NBA 2K15. This bundle is available now in the United States for $400 USD.
With so many awesome games being released in 2015 this is one gift which you truly can not go wrong with. If you like what you have read here make sure to click that share/+1 button and follow me on Twitter for the latest game and tech news.
Source: IGN
Monday, 8 December 2014
Is my gaming rig still necessary?
Around this time last year I was determined to become a part of the YouTube gaming community. I wanted to do it all, let's plays, montages and live streams but most importantly video editing. Video editing was one of those things which I always heard of but I never actually tried. During the next few months I went on to create a few let's plays and montages, but I couldn't help to notice one thing. My laptop's performance was terrible.
My laptop would often freeze whilst editing video and I would have to take breaks from editing in order to calm myself down. In order to create a much smoother workflow I decided I'm going to build myself a gaming PC. It would solve all of my problems. Right? With this new gaming PC I would finally be able to focus on the enjoyable aspect of YouTube and create fun and entertaining content for everyone to watch and share. Sadly this was not the case. A few months passed since I got my gaming PC and I was still missing something, only this time I knew exactly what it was and that was passion. Whenever I write a new article and I see that you're enjoying the content that's being produced, it acts like fuel for me. It pushes me to write more and it reassures me that I'm on the right path and that's the path of being a journalist. So now the question being is "Is my gaming PC still necessary?"
To be completely honest I've gotten quite tired with Windows 7 and the whole PC experience. I've covered a fair share of Apple devices and computers as a journalist and I think I'm ready to make the switch from PC to Mac and I have a variety of reasons to back up my decision.
The first one being all of the devices which I currently own are made by Apple apart from my PC. Ever since continuity became available on OS X Yosemite it seems like a mac would be the reasonable choice to go for.
The second reason is I've already invested so much money towards music and apps. Apps such as "Clear" are compatible with the Mac which means that all of my notes will just be there when I fire up the machine.
The third reason is I won't have to deal with cable management anymore. Which is always a plus in my book. Right now I have a ton of cables plugged into the back of my computer and it's just a pain to deal with. I sort of have OCD when it comes to keeping things organised. The iMac and the MacBook Air only have one power supply cable and that's what I call cable management.
Last but not least, the 5k iMac or the MacBook Air seem perfect for what I need them to be. I need a quick computer which is appealing to look at but also comfortable to use. I've always had a thing for Apple and the gaming rig which I have now is simply too much. Luckily I have a younger brother who is a YouTuber and I'm guessing that a PC such as this is exactly up his alley.
Thanks for checking this post out people. If you like what you have read here make sure to click that share/+1 button for the latest game and tech news and also follow me on Twitter for updates about the site.
Twitter: WordLoops
Friday, 28 November 2014
Trust Apple to fix your devices
As a lover of technology and video games I always take great care when handling my iPhone or when taking a brand new game out of the box for the first time. I am one of those individuals who orders the case and screen protector weeks before the actual device arrives. (Comment down below if you're one those people.)
A few weeks ago I noticed that something was wrong with my iPhone 5c. I didn't know what it was at first but after a while it hit me, my external speaker stopped working. The reason why I did not identify the problem straight away was I usually use my headphones when I'm writing or doing some things around the house. When my headphones were plugged in I heard everything absolutely fine and when I plugged them out there was nothing but a complete silence.
What do people do when they have a problem in 2014? They Google it. I sort of began to panic at this point because I had never encountered a problem with an iPhone or an Apple product before. I decided to scroll through some Apple forums in order to find a solution to my problem. But the solutions that some people recommended were just ridiculous. One person claimed that if you hit the bottom corner of the phone (where the external speaker was located) of off a hard surface it would fix the problem. "Oh yeah. The person who who buys his iPhone case in advance is going to smash it of off his desk." I don't think so.
So I then decided it was time to call Apple Care. When I called Apple care I was immediately welcomed by a strange voice automated operator. It asked me questions like "Give me the IMEI number of your device." and "What is the problem with your device?" I answered all of those questions and within seconds I was transferred to a living, breathing, human being named Andrew. Andrew one of the people who resolves problems like mine everyday was very helpful. He sent me out a link which then performed a diagnostics scan on my device and right away he knew that there was a problem with my external speaker. After I gave him my home address and email I was told that in two to five business days I would receive a package which I would then place my broken iPhone 5c into. He also told me that since my iPhone had a warranty the repair would be absolutely free and that they will send out a brand new iPhone after they received the broken unit.
For those of you out there who are still a bit wary about sending your iPhone to Apple and would prefer to go to your local repair store. Don't be. Apple has an incredible service for people like you and me and if I ever have another problem with an Apple device (which is like one in a million) Apple will be the first group that I will contact.
If you like what you have read here make sure to follow me on Twitter for the latest game and tech news and don't forget to click that share/+1 button. Have an awesome day and I will see you all soon !!!
Twitter: WordLoops
Thursday, 27 November 2014
Apple will stop iPhone 5c production in 2015
When the iPhone 5c first hit the market back in late 2013 it did not receive a warm welcome like all previous generation iPhones had before. It stood in the shadow of it's superior twin brother the iPhone 5s and was often referred to as the "cheap" iPhone, even though there was about a $100 difference between the two models. But many factors have contributed in making people believe that the 5c was a knock off version of the 5s.
The first one being it was made of plastic and not aluminium like the 5s. When people buy Apple's products they expect the product to feel like it's worth a thousand bucks. More than likely the first two words which are going to pop into your head when thinking of Apple are quality and exclusivity and hearing the word plastic or even using it when describing an Apple product is absolutely absurd.
The second factor which contributed to that cheap state of mind was the 5c did not feature Touch ID, a fingerprint scanner which had been implemented into the iPhone 5s. Many people saw this as a downgrade and the whole point of picking up a new iPhone every year is to benefit from the new features which the new device has to offer.
The third and fourth factors which led people to believe that the iPhone 5c was a joke were, the 5c featured an A6 chip. A chip which had already been living inside the iPhone 5 for a full year. The 5s on the other hand came with a shiny A7 chip with 64-bit architecture and an M7 motion co-processor. A lot of casual gamers and speed freaks viewed the iPhone 5s as an absolute necessity and would not give the 5c a second look.
Apple led a whole marketing campaign for the iPhone 5c claiming it was "For the colorful." It appealed to a few people until they received the actual device. Some people claimed that the colors looked washed out and not as vibrant as Apple said they would be. Which is why the blue and white versions of the device were proven in being the most popular color options which Apple had to offer.
Apple led a whole marketing campaign for the iPhone 5c claiming it was "For the colorful." It appealed to a few people until they received the actual device. Some people claimed that the colors looked washed out and not as vibrant as Apple said they would be. Which is why the blue and white versions of the device were proven in being the most popular color options which Apple had to offer.
I personally fell in love with the 5c when I picked it up last month. I've been using the device as my daily driver ever since and I can honestly say that all of the accusations about the iPhone 5c feeling cheap were way off. Which is why it's sad for me to say, according to Taiwan's Industrial and Commercial Times, Apple will be stopping the production of the iPhone 5c sometime in 2015. This is probably being done in order to keep the 5s and the current generation iPhone 6 and the 6 plus alive when the iPhone 6s comes out in 2015.
I will be picking up the iPhone 6s next year, but for those of you who are on the border whether to pick up the 5c for yourself or for a loved one, don't hesitate. It's a great device overall and ios 8 runs incredibly smooth on the device.
Thanks for checking this post out people and make sure to follow me on twitter for the latest game and tech news and click that share/+1 button above if you like what you have read here. Also the official WordLoops website should be launching in a few days which I will then post a link here which will redirect all of you awesome people to the new site. Have a great day and I'll see you all soon !!!
Twitter: WordLoops
I will be picking up the iPhone 6s next year, but for those of you who are on the border whether to pick up the 5c for yourself or for a loved one, don't hesitate. It's a great device overall and ios 8 runs incredibly smooth on the device.
Thanks for checking this post out people and make sure to follow me on twitter for the latest game and tech news and click that share/+1 button above if you like what you have read here. Also the official WordLoops website should be launching in a few days which I will then post a link here which will redirect all of you awesome people to the new site. Have a great day and I'll see you all soon !!!
Twitter: WordLoops
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subset: commoncrawl


text:
Letters: On the president, Christmas flap and more
The cruel fact is that gated communities are already penalized. We pay huge amounts to pave and slurry-coat our streets. We even pay to repair the damage done to our streets by the city sewer department when it repairs leaks. Workers leave unfinished ditches that we have to pay thousands of dollars to redo. Why would anyone seek to penalize homeowners who seek privacy and safety? Just because they can?
The mayor should retract his proposal and lead the community to an evenhanded solution.
Harvey Levine
Rancho Bernardo
Actions befit 'lame duck' moniker
Our government is facing serious issues – the deficit, tax legislation, immigration reform, etc. Yet with such serious things to deal with, Congress is focusing on the volume level of TV commercials? And, with the health care debate ongoing, lawmakers have the time to mandate rearview cameras on cars, to possibly save "dozens" of lives?
As much as I empathize with people who suffer through the jump in volume on commercials, I think they might be able to find the volume control on their remote. I have much more empathy for someone whose loved one has been backed over; however, maybe the nanny state might be better off telling those people to check behind the car before backing up.
We have a huge number of truly serious issues facing our country. It would be nice if the people we put in place to deal with those issues would spend their time dealing with those issues, not wasting time adding hundreds or thousands of pages to our legal code to deal with meaningless things.
Todd Maddison


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Calling virtual methods in C++ is prohibited, however there are a few situations, where it might be very useful.
Consider the following situation - pair of Parent and Child classes. Parent constructor requires a Child class to be instantiated, because it has to initialize it in a special way. Both Parent and Child may be derived, such that DerivedParent uses DerivedChild.
There's a problem, however - because in Parent::ctor call from DerivedParent::ctor, base class should have an instance of DerivedChild instead of Child. But that would require calling a virtual method some way, what is prohibited. I'm talking about something like this:
class Child
virtual std::string ToString() { return "Child"; }
class DerivedChild : public Child
std::string ToString() { return "DerivedChild"; }
class Parent
Child * child;
virtual Child * CreateChild() { return new Child(); }
Parent() { child = CreateChild(); }
Child * GetChild() { return child; }
class DerivedParent : public Parent
Child * CreateChild() { return new DerivedChild(); }
int main(int argc, char * argv[])
DerivedParent parent;
printf("%s\n", parent.GetChild()->ToString().c_str());
return 0;
Let's get a real-world example. Suppose, that I want to write wrapper for WinApi's windows. The base Control class should register class and instantiate a window (eg. RegisterClassEx and CreateWindowEx), to properly set it up (for example register class in such way, that window structure has additional data for class instance; set up generic WndProc for all Controls; put reference to
this by SetWindowLongPtr etc.)
On the other hand, derived class should be able to specify styles and extended styles, class name for window etc.
If constructing instance of window in the Control's constructor is a contract to be fulfilled, I see no other solution than to use VMs in ctor (what won't work).
Possible workarounds:
- Use static polymorphism (eg. class Derived : public Base), but it will not work, if one wants to derive from Derived;
- Pass a lambda from derived to base ctor if it is possible - it will work, but it's a total hardcore solution;
- Pass a ton of parameters from derived to base ctor - it shall work, but won't be neither elegant, nor easy to use.
I personally don't like neither of them. Out of curiosity, I checked, how the problem is solved in Delphi's VCL, and you know what, base class calls CreateParams, which is virtual (Delphi allows such calls and guarantees, that they are safe - class fields are initialized to 0 upon creating).
How can one overcome this language restriction?
Edit: In response to answers:
Call CreateChild from the derived constructor. You're already requiring CreateChild to be defined, so this is an incremental step. You can add a protected: void init() function in the base class to keep such initialization encapsulated.
It will work, but it's not an option - quoting the famous C++ FAQ:
The first variation is simplest initially, though the code that actually wants to create objects requires a tiny bit of programmer self-discipline, which in practice means you're doomed. Seriously, if there are only one or two places that actually create objects of this hierarchy, the programmer self-discipline is quite localized and shouldn't cause problems.
Use CRTP. Make the base class a template, have the child supply the DerivedType, and call the constructor that way. This kind of design can sometimes eliminate virtual functions completely.
It's not an option, because it will work only once, for base class and its immediate descendant.
Make the child pointer a constructor argument, for example to a factory function.
This is, so far, the best solution - injecting code into base ctor. In my case, I won't even need to do it, because I can just parametrize base ctor and pass values from the descendant. But it will actually work.
Use a factory function template to generate the child pointer of the appropriate type before returning a parent. This eliminates the complexity of a class template. Use a type traits pattern to group child and parent classes.
Yea, but it has some drawbacks:
- Someone, who derives from my classes may publish his ctor and bypass the security measures;
- It would prevent one from using references, one would have to use smart pointers.


text:
Ok so I was driving and reduced engine power light came on. I hooked it up to the OBD II and it says lost connection with throttle body actuator and says bank 1 and bank you.....i've checked the wires and didnt see anything wrong.
View questions for:All Chevrolet
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2005 Chevrolet Silverado 1500 Question: Codes lost connection with throttle body actuator and it has other codes
20133Trinity, Woodville, TX, April 24, 2013, 20:28
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text:
Traffic on the A406 northbound is facing delays after a crash near the Ilford flyover involving three cars this afternoon (Wednesday).]]>
The building site supervisor who was on duty when a 16-year-old apprentice fell from scaffolding to his death has been found not guilty of manslaughter.]]>
A petition has been launched opposing plans to expand a school after they were approved by the council.]]>
A man who police believe has recorded the highest speed ever by a motorcyclist in the UK while carrying a pillion passenger has been banned from driving.]]>
Police are appealing to the public for information after a 26-year-old man was shot in the chest and head in Wanstead.]]>
A couple rushed home from a shopping trip to find a tree had smashed into their house.]]>
A 27-year-old man has appeared in court in connection with a huge fire at an industrial park.]]>
Two donkeys showed the way at a church's Palm Sunday procession before being blessed by the priest-in-charge.]]>
A man who attempted to rob a bookmakers after pretending his tin of pilchards was a bomb has been given a suspended prison sentence.]]>
Wandsworth prisoner Neil Moore was on remand for defrauding £2 million when he staged an "ingenious" escape plot to walk free from jail.]]>
Police have launched an investigation after a deaf homeless woman was allegedly assaulted at a Tube station.]]>
A building site supervisor broke down today when recalling the moment a 16-year-old apprentice under his watch fell to his death on a building site.]]>
Three Redbridge children's centres are among a select number to be judged as 'outstanding' in the most recent OFSTED inspection.]]>
Those living under flight-paths will be "relieved" according to the council leader after the decision to reject airport expansion plans was made.]]>
A black cab driver has been jailed for 10 years after sexually assaulting two women who both fell asleep in his cab.]]>
The start of the growing season was celebrated with a special event at a community garden on Saturday.]]>
Homes were evacuated after a tree fell on a house yesterday afternoon.]]>
Flames 25 ft high could be seen tearing through the outhouse of a kebab shop in South Woodford on Saturday night.]]>
A Met officer and decorated army reservist faces losing both his careers for accidentally bringing home bullets from a military training camp – which police found after he was burgled.]]>
The latest news from Redbridge's clubs and societies.]]>
Fire cadets were given an hour-long talk on the consequences of knife crime this week.]]>
Labour leader Ed Miliband rolled into Ilford North this morning on the first stop of the party's campaign – just hours after he was grilled by Jeremy Paxman on live television.]]>
The pilots who risked and gave their lives battling the Zeppelins which unleashed terror on London's streets are to be remembered 100 years on.]]>
The centre of a new study, tracking the progress of more than 80,000 babies born to mothers in Redbridge and Havering, opened last week in Goodmayes.]]>
Children at a primary school took part in a workshop which ended in the creation of a huge mosaic.]]>


text:
The Lastolite All-In-One Umbrella Kit (34") features a 34" (80 cm) umbrella that can be configured as a silver bounce umbrella, a white bounce umbrella, a combined silver and white bounce umbrella or a shoot-through umbrella--giving you pretty much all the umbrella variations you need. A hotshoe tilthead mount and a padded shoulder bag are included in the kit.
- Can be used as a silver or white bounce, a silver and white bounce or shoot-through umbrella
- Padded shoulder bag
- Hotshoe tilthead with ratchet adjustment
- 8mm umbrella shaft


text:
OpenStack doesn't scale. Allegedly.
By Paul Miller on March 20, 2015
OpenStack doesn't scale. Allegedly.: Shock news, from a company that wants paid to help you handle complex OpenStack deployments. Scaling is hard. Scaling anything is harder than running it on a server or two. This is not surprising. Most OpenStack deployments tend to be relatively small. This isn't surprising either. Most comparable public/hybrid cloud deployments tend […]
Posted in Featured Posts, Open Source, Platforms | Tagged cloud computing, Mirantis, openstack, Scalability, tftd | Leave a response
Hyper-Converged Confusion
By Randy Bias on March 2, 2015
I have had my doubts about converged and hyper-converged infrastructure since the Vblock launched, but I eventually came around to understanding why enterprises love the VCE Vblock. I am now starting to think of converged infrastructure (CI) as really "enterprise computing 2.0". CI dramatically reduces operational costs and allows for the creation of relatively homologous […]
Posted in Featured Posts, Platforms | Tagged cloud computing | Leave a response
The EMC Federation Joins the OpenStack Foundation
By Randy Bias on December 15, 2014
Recently a major set of milestones was reached for the EMC Federation's involvement with OpenStack. First, EMC and it's affiliated companies and brands (VMware, VCE, Pivotal, RSA, Cloudscaling) determined a cohesive strategy for engagement with the OpenStack Foundation Board. Second, EMC appointed a VMware employee, Sean Roberts (@sarob), as the official representative of EMC and […]
Posted in Featured Posts, Platforms | Tagged cloud computing, emc, openstack, vmware | 1 Response
The 6 Requirements of Enterprise-grade OpenStack, Part 3
By Randy Bias on May 7, 2014
In part 1 and part 2 of this series I introduced the core ideas around defining the requirements and then discussed the first four. Today we'll discuss the final two requirements and tie it all together. Onwards and upwards! Requirement #5 – Scalable, Elastic, and Performant Enterprise-grade has to mean something. In the past, enterprise-grade […]
Posted in Featured Posts, Platforms | Tagged openstack
The 6 Requirements of Enterprise-grade OpenStack, Part 2
By Randy Bias on May 1, 2014
In part 1 of this series earlier this week, I introduced The 6 Requirements of Enterprise-grade OpenStack. Today, I'm going to dig into the next two major requirements: Open Architectures and Hybrid Cloud Interoperability. Let's get started. Requirement #3: Open Architectures & Reducing Vendor Lock-in We already covered building a robust control plane and cloud […]
Posted in Featured Posts, Platforms | Tagged openstack | 2 Responses
The 6 Requirements of Enterprise-grade OpenStack, Part 1
By Randy Bias on April 28, 2014
Introduction OpenStack is an amazing foundation for building an enterprise-grade private cloud. The great OpenStack promise is to be the cloud operating system kernel of a new generation. Unfortunately, OpenStack is not a complete cloud operating system, and while it might become one over time, it's probably best to look at OpenStack as a kernel, […]
Posted in Enterprise, Featured Posts, Platforms | Tagged openstack | 3 Responses
Is Your Mobile Strategy A Coconut Or Banana?
By Quinton Wall on April 22, 2014
Don't climb the coconut tree, when a banana will do just fine. My team and I spend a lot of time talking to customers about their mobile strategy. Generally, we hear the same two things: Either,customers don't know where to start with mobile, or their strategy involves solving too many things (security, integration, etc) to […]
Posted in Enterprise, Mobile, Platforms, Technology | 1 Response
Docker Red Hat and Containerization Wreck Virtualization
By Adron Hall on April 15, 2014
Conversation has popped up around a few tweets Alex Williams regarding virtualization at the Red Hat Summit. One of the starts to the conversation. How Project Atomic fits with Docker, geard, etc. http://t.co/qjFFGR2nI8— Alex Williams (@alexwilliams) April 15, 2014 Paraphrased the discussion has been shaped around asking, "Why is OS-level virtualization via containers (namely Docker) become such a massive hot topic?" […]
Posted in Featured Posts, Platforms | Tagged conferences, container, containerization, Containers, docker, os-level virutalization, red hat, Virtual machine, virtualization | 2 Responses
Microsoft Corporate Vice President Quentin Clark discusses data, data platforms, and more
By Paul Miller on April 2, 2014
The Data Platform Group at Microsoft does a lot, from SQL Server and their Hadoopey HDInsight offering through to Business Intelligence and analytics capabilities which sit in or on top of the humble Excel spreadsheet. I've touched upon pieces of this whole before, in a 2009 podcast on Azure with Amitabh Srivastava (then Corporate VP […]
Posted in Platforms | Tagged azure data market, BI, big data, Business Intelligence, cloud computing, data markets, data platform group, Enterprise Computing, excel, microsoft, Microsoft Excel, Microsoft SQL Server, open data, Podcast, quentin clark, sql server
Cloud Just Got Real – The Race Begins
By Randy Bias on March 27, 2014
This week, Google hosted its Cloud Platform Live event. Some people were a little surprised at my enthusiastic live twitter coverage for a number of Google's announcements. I have been waiting for them to "go big or go home" for a while now. My biggest surprise was how long it took Google to get up […]
Posted in Featured Posts, Platforms | Tagged Amazon Web Services, cloud computing, google, google app engine, Google Cloud Platform
Google is Amazon's Only Real Competition
By Randy Bias on February 6, 2014
Recently, Barb Darrow wrote a great note to Google Compute Platform, suggesting "8 things it could do to freak Amazon out." As long term readers know, I predicted Google's entry into the public Infrastructure-as-a-Service (IaaS) market long before anyone else. Cloudscaling is also well known for having created the Google Compute Engine (GCE) APIs for […]
Posted in Featured Posts, Platforms | Tagged amazon, cloud computing, gogrid, google, google compute engine, openstack | 3 Responses
OpenStack: A Community Torn Apart – Freedland, Bias and Scoble
By Ofir Nachmani on January 10, 2014
Last month, I attended the OpenStack summit in Tel Aviv. This was yet another great event brought to us by the brilliant Gigaspaces team (especially @shar1z) headed by one of the most important cloud evangelists in Israel and the world, @natishalom. OpenStack aims to provide the ubiquitous open source cloud computing platform for public and private clouds. Wikipedia […]
Posted in Analysis, Business, Enterprise, Featured Posts, Infrastructure, Platforms, Strategy, Trends & Concepts | Tagged aws, cloud computing, cloudscaling, Coopetition, LivePerson, Mirantis, opensource, openstack, randy bias, vmware | 2 Responses
2013 Was YEAR ONE for OpenStack
By Randy Bias on December 23, 2013
It's useful for all in the OpenStack community to remember that many believe OpenStack was not ready for prime time until Essex or possibly Folsom. Some might even claim Grizzly was the first true production release. My money is on Folsom for what it's worth. What this means is that 2013 is YEAR ONE for OpenStack in […]
Posted in Featured Posts, Platforms | Tagged cloud computing, openstack, predictions | 2 Responses
Is PaaS dying?
By Paul Miller on December 18, 2013
The 'platform' tier in the middle of cloud computing's architecture is being squeezed, folded and reshaped beyond recognition. Even with continued investment, can it survive the transformative pressures forcing down upon it from the software/application layer above, or the apparently inexorable upward movement from the infrastructure layer upon which it rests? To look at recent […]
Posted in Featured Posts, Open Source, Platforms | Tagged cloud computing, Enterprise Computing, paas, platform as a service | 1 Response
Neutron in Production: Work in Progress or Ready for Prime Time?
By Randy Bias on December 9, 2013
Earlier this week, we hosted an OpenStack Meetup at the offices of our customer, EVault, here in San Francisco. Titled "Neutron Networking and SDN in Production," the Meetup featured panelists from major contributors to Neutron and those offering open source plugins that leverage Neutron. (SiliconANGLE covered the event live, and a replay will be embedded […]
Posted in Featured Posts, Platforms | Tagged cloud computing, meetups, networking, Neutron, Nova, openstack, SDN


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Are you Svetlana Gingis-Velitski?Claim your profile
Publications (20)115.07 Total impact
Article: Tumor-derived microparticles induce bone marrow-derived cell mobilization and tumor homing: A process regulated by osteopontin[Show abstract] [Hide abstract]
ABSTRACT: Acute chemotherapy can induce rapid bone-marrow derived pro-angiogenic cell (BMDC) mobilization and tumor homing, contributing to tumor regrowth. In order to study the contribution of tumor cells to tumor regrowth following therapy, we focused on tumor-derived microparticles (TMPs). EMT/6 murine-mammary carcinoma cells exposed to paclitaxel chemotherapy exhibited an increased number of TMPs and significantly altered their angiogenic properties. Similarly, breast cancer patients had increased levels of plasma MUC-1+TMPs following chemotherapy. In addition, TMPs from cells exposed to paclitaxel induced higher BMDC mobilization and colonization but had no increased effect on angiogenesis in Matrigel plugs and tumors than TMPs from untreated cells. Since TMPs abundantly express osteopontin, a protein known to participate in BMDC trafficking, the impact of osteopontin-depleted TMPs on BMDC mobilization, colonization, and tumor angiogenesis was examined. While EMT/6 tumors grown in mice inoculated with osteopontin-depleted TMPs had lower numbers of BMDC infiltration and microvessel density compared with EMT/6 tumors grown in mice inoculated with wild-type TMPs, no significant difference in tumor growth was seen between the two groups. However, when BMDCs from paclitaxel-treated mice were injected into wild-type EMT/6-bearing mice, a substantial increase in tumor growth and BMDC infiltration was detected compared to osteopontin-depleted EMT/6-bearing mice injected with BMDCs from paclitaxel-treated mice. Collectively, our results suggest that osteopontin expressed by TMPs play an important role in BMDC mobilization and colonization of tumors, but is not sufficient to enhance the angiogenic activity of BMDCs in tumors. © 2013 Wiley Periodicals, Inc.International Journal of Cancer 07/2014; 135(2). DOI:10.1002/ijc.28678 · 6.20 Impact Factor
Article: Differential Therapeutic Effects of Anti-VEGF-A Antibody in Different Tumor Models: Implications for Choosing Appropriate Tumor Models for Drug Testing[Show abstract] [Hide abstract]
ABSTRACT: We previously reported that the host response to certain chemotherapies can induce primary tumor regrowth, angiogenesis, and even metastases in mice, but the possible impact of anti-vascular endothelial growth factor-A (VEGF-A) therapy in this context has not been fully explored. We therefore used combinations of anti-VEGF-A with chemotherapy on various tumor models in mice including primary tumors, experimental lung metastases, and spontaneous lung metastases of 4T1-breast and CT26-colon murine cancer cell lines. Our results show that a combined treatment with anti-VEGF-A and folinic acid/5-fluorouracil/oxaliplatin (FOLFOX) but not with anti-VEGF-A and gemcitabine/cisplatinum (Gem/CDDP) enhances the treatment outcome partly due to reduced angiogenesis, in both primary tumors and in experimental lung metastases models. However, neither treatment group exhibited an improved treatment outcome in the spontaneous lung metastases model nor were changes in endothelial cell numbers found at metastatic sites. Since chemotherapy has recently been shown to induce tumor cell invasion, we tested the invasion properties of tumor cells when exposed to plasma from FOLFOX-treated mice or cancer patients. While plasma from FOLFOX-treated mice or patients induced invasion properties of tumor cells, the combination of anti-VEGF-A and FOLFOX abrogated these effects, despite the reduced plasma VEGF-A levels detected in FOLFOX-treated mice. These results suggest that the therapeutic impact of antiangiogenic drugs varies in different tumor models, and that anti-VEGF-A therapy can block the invasion properties of tumor cells in response to chemotherapy. These results may implicate an additional therapeutic role for anti-VEGF-A when combined with chemotherapy.Molecular Cancer Therapeutics 10/2013; 13(1). DOI:10.1158/1535-7163.MCT-13-0356 · 5.60 Impact Factor
Article: Abstract LB-343: Host response to paclitaxel chemotherapy promotes metastasis via the secretion of VEGF-C by macrophages.Cancer Research 08/2013; 73(8 Supplement):LB-343-LB-343. DOI:10.1158/1538-7445.AM2013-LB-343 · 9.28 Impact Factor
Article: Porfimer-sodium (Photofrin-II) in combination with ionizing radiation inhibits tumor-initiating cell proliferation and improves glioblastoma treatment efficacy.[Show abstract] [Hide abstract]
ABSTRACT: Tumor relapse and tumor cell repopulation has been explained partially by the drug-free break period between successive conventional treatments. Strategies to overcome tumor relapse have been proposed, such as the use of chemotherapeutic drugs or radiation in small, frequent fractionated doses without an extended break period between treatment intervals. Yet, tumors usually acquire resistance and eventually escape the therapy. Several mechanisms have been proposed to explain the resistance of tumors to therapy, one of which involves the cancer stem cell or tumor-initiating cell (TIC) concept. TICs are believed to resist many conventional therapies, in part due to their slow proliferation and self-renewal capacities. Therefore, emerging efforts to eradicate TICs are being undertaken. Here we show that treatment with Photofrin II, among the most frequently used photosensitizers, sensitized a TIC-enriched U-87MG human glioblastoma cell to radiation, and improve treatment outcome when used in combination with radiotherapy. A U-87MG tumor cell population enriched with radiation-resistant TICs becomes radio-sensitive, and an inhibition of cell proliferation and an increase in apoptosis are found in the presence of Photofrin II. Furthermore, U-87MG tumors implanted in mice treated with Photofrin II and radiation exhibit a significant reduction in angiogenesis and vasculogenesis, and an increased percentage of apoptotic TICs when compared with tumors grown in mice treated with radiation alone. Collectively, our results offer a new possible explanation for the therapeutic effects of radiosensitizing agents, and suggest that combinatorial treatment modalities can effectively prolong treatment outcome of glioblastoma tumors by inhibiting tumor growth mediated by TICs.Cancer biology & therapy 10/2012; 14(1). DOI:10.4161/cbt.22630 · 3.29 Impact Factor
Article: Tumor-initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs.[Show abstract] [Hide abstract]
ABSTRACT: Tumor-initiating cells (TICs) are a subtype of tumor cells believed to be critical for initiating tumorigenesis. We sought to determine the angiogenic properties of TICs in different tumor types including U-87MG (glioblastoma), HT29 (colon), MCF7 (breast), A549 (non-small-cell lung), and PANC1 (pancreatic) cancers. Long-term cultures grown either as monolayers ("TIC-low") or as nonadherent tumor spheres ("TIC-high") were generated. The TIC-high fractions exhibited increased expression of stem cell surface markers, high aldehyde dehydrogenase activity, high expression of p21, and resistance to standard chemotherapy in comparison to TIC-low fractions. Furthermore, TICs from U-87MG and HT29 but not from MCF7, A549, and PANC1 tumor types possess increased angiogenic activity. Consequently, the efficacy of vascular endothelial growth factor-A (VEGF-A) neutralizing antibody is limited only to those tumors that are dependent on VEGF-A activity. In addition, such therapy had little or reversed antiangiogenic effects on tumors that do not necessarily rely on VEGF-dependent angiogenesis. Differential angiogenic activity and antiangiogenic therapy sensitivity were also observed in TICs of the same tumor type, suggesting redundant angiogenic pathways. Collectively, our results suggest that the efficacy of antiangiogenic drugs is dependent on the angiogenic properties of TICs and, therefore, can serve as a possible biomarker to predict antiangiogenic treatment efficacy.Stem Cells 07/2012; 30(9):1831-41. DOI:10.1002/stem.1170 · 7.70 Impact Factor
Article: Abstract 4362: Identification and isolation of host factors in response to therapy: an approach to identify new targets for cancer therapyCancer Research 06/2012; 72(8 Supplement):4362-4362. DOI:10.1158/1538-7445.AM2012-4362 · 9.28 Impact Factor
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ABSTRACT: Results obtained from preclinical studies have shown that endothelial progenitor cells (EPCs) play a crucial role in tumor growth and metastasis. In the clinic, EPCs are present in the peripheral blood of cancer patients in higher numbers than in healthy subjects. These cells are mobilized from the bone marrow compartment to the periphery in response to certain cytokines and growth factors. Growing body of evidence suggests that following acute cytotoxic drug therapy levels of circulating EPCs (CEPs) can change significantly in both mouse and human. These changes may predict the efficacy of some anticancer drug treatments. Therefore, the validation and standardization of a procedure to detect CEPs and monitor their kinetic is an important step towards the use of such cells as a possible biomarker to predict clinical outcome. In this chapter, we describe a flow cytometry technique to detect CEPs obtained from human blood specimens stored in both fresh and frozen conditions.Methods in molecular biology (Clifton, N.J.) 01/2012; 904:165-72. DOI:10.1007/978-1-61779-943-3_14 · 1.29 Impact Factor
Article: Host Response to Short-term, Single-Agent Chemotherapy Induces Matrix Metalloproteinase-9 Expression and Accelerates Metastasis in Mice[Show abstract] [Hide abstract]
ABSTRACT: Mounting evidence suggests that bone marrow-derived cells (BMDC) contribute to tumor growth, angiogenesis, and metastasis. In acute reactions to cancer therapy, several types of BMDCs are rapidly mobilized to home tumors. Although this host reaction to therapy can promote tumor regrowth, its contribution to metastasis has not been explored. To focus only on the effects of chemotherapy on the host, we studied non-tumor-bearing mice. Plasma from animals treated with the chemotherapy paclitaxel induced angiogenesis, migration, and invasion of tumor cells along with host cell colonization. Lesser effects were seen with the chemotherapy gemcitabine. Conditioned medium from BMDCs and plasma from chemotherapy-treated mice each promoted metastatic properties in tumor cells by inducing matrix metalloproteinase-9 (MMP9) and epithelial-to-mesenchymal transition. In mice in which Lewis lung carcinoma cells were injected intravenously, treatment with paclitaxel, but not gemcitabine or vehicle, accelerated metastases in a manner that could be blocked by an MMP9 inhibitor. Moreover, chimeric mice reconstituted with BMDC where MMP9 activity was attenuated did not support accelerated metastasis by carcinoma cells that were pretreated with chemotherapy before their introduction to host animals. Taken together, our findings illustrate how some chemotherapies can exert prometastatic effects that may confound treatment outcomes.Cancer Research 11/2011; 71(22):6986-96. DOI:10.1158/0008-5472.CAN-11-0629 · 9.28 Impact Factor
Article: G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonist.[Show abstract] [Hide abstract]
ABSTRACT: Recombinant granulocyte colony-stimulating factor (G-CSF) is used to accelerate recovery from chemotherapy-induced myelosuppression. G-CSF has been recently shown to stimulate angiogenesis mediated by several types of bone marrow-derived cell populations. To investigate whether G-CSF may alter tumor response to therapy, we studied Lewis lung and EMT/6 breast carcinomas in mice treated with paclitaxel (PTX) chemotherapy in combination with G-CSF. We compared the results obtained to mice treated with PTX and AMD3100, a small-molecule drug antagonist of CXCR4 which, like G-CSF, can be used to mobilize hematopoietic cells. We show that PTX combined with G-CSF treatment facilitates revascularization, leading to an improvement in blood perfusion in LLC tumors, and a decrease in hypoxia in EMT/6 tumors, thus enhancing tumor growth in comparison to PTX or PTX and AMD3100 therapies. We found that hemangiocytes but not Gr-1(+) CD11b(+) cells colonize EMT/6 tumors after treatment with PTX and G-CSF, but not PTX and AMD3100, and therefore may contribute to angiogenesis. However, increases in hemangiocyte colonization were not observed in LLC PTX and G-CSF-treated tumors, suggesting distinct mechanisms of tumor revascularization after G-CSF. Overall, our observations suggest that despite its known considerable clinical benefits, G-CSF might contribute to tumor revascularization by various mechanisms, and diminish the antitumor activity of chemotherapy, an effect that can be prevented by AMD3100.Blood 06/2011; 118(12):3426-35. DOI:10.1182/blood-2010-11-320812 · 9.78 Impact Factor
Article: The angiogenic profile of colorectal cancer patients following open or laparoscopic colectomyCancer biology & therapy 10/2010; 10(7):686-8. DOI:10.4161/cbt.10.7.13240 · 3.29 Impact Factor
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ABSTRACT: Heparanase is a mammalian endo-beta-d-glucuronidase that can cleave heparan sulfate side chains, an activity strongly implicated in tumor cell dissemination. The current study aimed to identify and characterize heparanase splice variants. LEADS, Compugen's alternative splicing modeling platform (Compugen, Tel Aviv, Israel), was used to search for splice variants in silico; tumor-derived cell lines (i.e., CAG myeloma) and tumor biopsies were utilized to validate T5 expression in vivo; signaling (i.e., Src phosphorylation) was evaluated following T5 gene silencing or overexpression and correlated with cell proliferation, colony formation, and tumor xenograft development. A novel spliced form of human heparanase, termed T5, was identified. In this splice variant, 144 bp of intron 5 are joined with exon 4, which results in a truncated, enzymatically inactive protein. T5 overexpression resulted in increased cell proliferation and larger colonies in soft agar, mediated by Src activation. Furthermore, T5 overexpression markedly enhanced tumor xenograft development. T5 expression is up-regulated in 75% of human renal cell carcinoma biopsies examined, which suggests that this splice variant is clinically relevant. Controls included cells overexpressing wild-type heparanase or an empty plasmid and normal-looking tissue adjacent the carcinoma lesion. T5 is a novel functional splice variant of human heparanase endowed with protumorigenic characteristics.-Barash, U., Cohen-Kaplan, V., Arvatz, G., Gingis-Velitski, S., Levy-Adam, F., Nativ, O., Shemesh, R., Ayalon-Sofer, M., Ilan, N., Vlodavsky, I. A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.The FASEB Journal 12/2009; 24(4):1239-48. DOI:10.1096/fj.09-147074 · 5.48 Impact Factor
Article: Structure-Function Approach Identifies a COOH-Terminal Domain That Mediates Heparanase Signaling[Show abstract] [Hide abstract]
ABSTRACT: Heparanase is an endo-beta-d-glucuronidase capable of cleaving heparan sulfate, activity that is strongly implicated in cellular invasion associated with tumor metastasis, angiogenesis, and inflammation. In addition, heparanase was noted to exert biological functions apparently independent of its enzymatic activity, enhancing the phosphorylation of selected protein kinases and inducing gene transcription. A predicted three-dimensional structure of constitutively active heparanase clearly delineates a TIM-barrel fold previously anticipated for the enzyme. Interestingly, the model also revealed the existence of a COOH-terminal domain (C-domain) that apparently is not an integral part of the TIM-barrel fold. We provide evidence that the C-domain is critical for heparanase enzymatic activity and secretion. Moreover, the C-domain was found to mediate nonenzymatic functions of heparanase, facilitating Akt phosphorylation, cell proliferation, and tumor xenograft progression. These findings support the notion that heparanase exerts enzymatic activity-independent functions, and identify, for the first time, a protein domain responsible for heparanase-mediated signaling. Inhibitors directed against the C-domain, combined with inhibitors of heparanase enzymatic activity, are expected to neutralize heparanase functions and to profoundly affect tumor growth, angiogenesis, and metastasis.Cancer Research 03/2009; 69(5):1758-67. DOI:10.1158/0008-5472.CAN-08-1837 · 9.28 Impact Factor
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ABSTRACT: Heparanase is an endoglycosidase which cleaves heparan sulfate and hence participates in degradation and remodeling of the extracellular matrix. Importantly, heparanase activity correlated with the metastatic potential of tumor-derived cells, attributed to enhanced cell dissemination as a consequence of heparan sulfate cleavage and remodeling of the extracellular matrix barrier. Heparanase has been characterized as a glycoprotein, yet glycan biochemical analysis was not performed to date. Here, we applied the Qproteometrade mark GlycoArray kit to perform glycan analysis of heparanase, and compared the kit results with the more commonly used biochemical analyses. We employed fibroblasts isolated from patients with I-cell disease (mucolipidosis II), fibroblasts deficient of low density lipoprotein receptor-related protein and fibroblasts lacking mannose 6-phosphate receptor, to explore the role of mannose 6-phosphate in heparanase uptake. Iodinated heparanase has been utilized to calculate binding affinity. We provide evidence for hierarchy of binding to cellular receptors as a function of heparanase concentration. We report the existence of a high affinity, low abundant (i.e., low density lipoprotein receptor-related protein, mannose 6-phosphate receptor), as well as a low affinity, high abundant (i.e., heparan sulfate proteoglycan) receptors that mediate heparanase binding, and suggest that these receptors co-operate to establish high affinity binding sites for heparanase, thus maintaining extracellular retention of the enzyme tightly regulated.The International Journal of Biochemistry & Cell Biology 02/2008; 40(3):530-42. DOI:10.1016/j.biocel.2007.09.003 · 4.24 Impact Factor
Article: Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing.[Show abstract] [Hide abstract]
ABSTRACT: Heparanase is a mammalian endo-beta-D-glucuronidase capable of cleaving HS side chains at a limited number of sites, activity that is strongly implicated in tumor metastasis, neovascularization, inflammation, and autoimmunity. Clinically, up-regulation of heparanase mRNA and protein expression has been documented in a variety of primary human tumors, correlating with reduced postoperative survival and increased lymph node and distant metastasis, thus providing strong clinical support for the prometastatic feature of the enzyme and making it an attractive target for the development of anticancer and anti-inflammatory drugs. Screening a panel of monoclonal antibodies for their ability to inhibit heparanase enzymatic activity, we noted that one hybridoma, 6F8, exhibited the opposite effect and significantly enhanced heparanase activity. Here, we provide evidence that antibody 6F8 enhances the activity of recombinant and cellular heparanase, facilitates invasion of tumor-derived cells in vitro, and improves wound healing in a mouse punch model in vivo. These results support a role of heparanase in the course of wound healing and, moreover, suggest that monoclonal antibodies can be applied clinically for the enhancement, rather than inhibition, of certain enzymes.The FASEB Journal 01/2008; 21(14):3986-93. DOI:10.1096/fj.07-8866com · 5.48 Impact Factor
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ABSTRACT: The endoglycosidase heparanase is the predominant enzyme that degrades heparan sulfate side chains of heparan sulfate proteoglycans, activity that is strongly implicated in tumor metastasis. Apart of its well characterized enzymatic activity, heparanase was noted to exert also enzymatic-independent functions. Among these is the induction of Akt/PKB phosphorylation noted in endothelial- and tumor-derived cells. Protein domains of heparanase required for signaling were not identified to date, nor were identified heparanase binding proteins/receptors capable of transmitting heparanase signals. Here, we examined the possible function of mannose 6-phosphate receptor (MPR) and low-density lipoprotein-receptor related protein (LRP), recently implicated in cellular uptake of heparanase, as heparanase receptors mediating Akt phosphorylation. We found that heparanase addition to MPR- and LRP-deficient fibroblasts elicited Akt activation indistinguishable from control fibroblasts. In contrast, disruption of lipid rafts abrogated Akt/PKB phosphorylation following heparanase addition. These results suggest that lipid raft-resident receptor mediates heparanase signaling.Biochemical and Biophysical Research Communications 11/2007; 361(4):829-34. DOI:10.1016/j.bbrc.2007.06.188 · 2.28 Impact Factor
Article: PO04 Heparanase induces TFPI expression and extracellular accumulation in endothelial and tumor cellsThrombosis Research 01/2007; 120. DOI:10.1016/S0049-3848(07)70157-3 · 2.43 Impact Factor
Article: Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.[Show abstract] [Hide abstract]
ABSTRACT: Heparanase is a mammalian endo-beta-D-glucuronidase that cleaves heparan sulfate side chains at a limited number of sites. Such enzymatic activity is thought to participate in degradation and remodeling of the extracellular matrix and to facilitate cell invasion associated with tumor metastasis, angiogenesis and inflammation. Traditionally, heparanase activity was well correlated with the metastatic potential of a large number of tumor-derived cell types. More recently, heparanase upregulation has been documented in an increasing number of primary human tumors, correlating with poor postoperative survival and increased tumor vascularity. Here, we employed anti-heparanase 733 polyclonal antibody that preferentially recognizes the 50 kDa active heparanase subunit over the 65 kDa proenzyme, as well as anti-heparanase 92.4 monoclonal antibody that recognizes both the latent and the active enzyme, to follow heparanase expression, processing and localization throughout the adenoma-carcinoma transition of the colon epithelium. Normal (nondysplastic) mucosa of the large bowel near epithelial neoplasms, as well as areas of mild dysplasia in adenomas, exhibited a strong reactivity with antibody 733 that became even stronger in foci of moderate dysplasia. Interestingly, although reactivity with antibody 733 was markedly reduced in severe dysplasia and in colorectal carcinoma, response to antibody 92.4 exhibited the opposite trend and staining intensities increased in parallel with tumor stage, the highest being in carcinoma cells. Involvement of latent heparanase (detected by 92.4, but not by 733 antibody) in tumor progression was suggested by activation of the Akt/PKB signal transduction pathway upon heparanase overexpression or exogenous addition to HT29 human colon carcinoma cells. These results suggest that heparanase expression is induced during colon carcinogenesis, and that its processing, conformation and localization are tightly regulated during the course of colon adenoma-carcinoma progression.Modern Pathology 07/2006; 19(6):878-88. DOI:10.1038/modpathol.3800603 · 6.36 Impact Factor
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ABSTRACT: Heparanase is a mammalian endoglycosidase that degrades heparan sulfate (HS) at specific intrachain sites, an activity that is strongly implicated in cell dissemination associated with metastasis and inflammation. In addition to its structural role in extracellular matrix assembly and integrity, HS sequesters a multitude of polypeptides that reside in the extracellular matrix as a reservoir. A variety of growth factors, cytokines, chemokines, and enzymes can be released by heparanase activity and profoundly affect cell and tissue function. Thus, heparanase bioavailability, accessibility, and activity should be kept tightly regulated. We provide evidence that HS is not only a substrate for, but also a regulator of, heparanase. Addition of heparin or xylosides to cell cultures resulted in a pronounced accumulation of, heparanase in the culture medium, whereas sodium chlorate had no such effect. Moreover, cellular uptake of heparanase was markedly reduced in HS-deficient CHO-745 mutant cells, heparan sulfate proteoglycan-deficient HT-29 colon cancer cells, and heparinase-treated cells. We also studied the heparanase biosynthetic route and found that the half-life of the active enzyme is approximately 30 h. This and previous localization studies suggest that heparanase resides in the endosomal/lysosomal compartment for a relatively long period of time and is likely to play a role in the normal turnover of HS. Co-localization studies and cell fractionation following heparanase addition have identified syndecan family members as candidate molecules responsible for heparanase uptake, providing an efficient mechanism that limits extracellular accumulation and function of heparanase.Journal of Biological Chemistry 11/2004; 279(42):44084-92. DOI:10.1074/jbc.M402131200 · 4.60 Impact Factor
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ABSTRACT: Heparanase is a heparan sulfate degrading endoglycosidase participating in extracellular matrix degradation and remodeling. Heparanase is synthesized as a 65 kDa non-active precursor that subsequently undergoes proteolytic cleavage, yielding 8 kDa and 50 kDa protein subunits that heterodimerize to form an active enzyme. The protease responsible for heparanase processing is currently unknown, as is the sub-cellular processing site. In this study, we characterize an antibody (733) that preferentially recognizes the active 50 kDa heparanase form as compared to the non-active 65 kDa heparanase precursor. We have utilized this and other anti-heparanase antibodies to study the cellular localization of the latent 65 kDa and active 50 kDa heparanase forms during uptake and processing of exogenously added heparanase. Interestingly, not only the processed 50 kDa, but also the 65 kDa heparanase precursor was localized to perinuclear vesicles, suggesting that heparanase processing occurs in lysosomes. Indeed, heparanase processing was completely inhibited by chloroquine and bafilomycin A1, inhibitors of lysosome proteases. Similarly, processing of membrane-targeted heparanase was also chloroquine-sensitive, further ruling out the plasma membrane as the heparanase processing site. Finally, we provide evidence that antibody 733 partially neutralizes the enzymatic activity of heparanase, suggesting that the N-terminal region of the molecule is involved in assuming an active conformation. Monoclonal antibodies directed to this region are likely to provide specific heparanase inhibitors and hence assist in resolving heparanase functions under normal and pathological conditions.Journal of Cell Science 06/2004; 117(Pt 11):2249-58. DOI:10.1242/jcs.01068 · 5.33 Impact Factor
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ABSTRACT: Heparanase is a mammalian endoglycosidase that degrades heparan sulfate (HS) at specific intra-chain sites. Blood-borne neutrophils, macrophages, mast cells, and platelets exhibit heparanase activity that is thought to be stored in specific granules. The degranulated heparanase is implicated in extravasation of metastatic tumor cells and activated cells of the immune system. Degranulation and heparanase release in response to an inflammatory stimulus or platelet activation would facilitate cellular extravasation directly, by altering the composition and structural integrity of the extracellular matrix, or indirectly, by releasing HS-bound proinflammatory cytokines and chemokines. We hypothesized that in addition to such indirect effect, the released heparanase may also locally affect and activate neighboring cells such as endothelial cells. Here, we provide evidence that addition of the 65-kDa latent heparanase to endothelial cells enhances Akt signaling. Heparanase-mediated Akt phosphorylation was independent of its enzymatic activity or the presence of cell membrane HS proteoglycans and was augmented by heparin. Moreover, addition of heparanase stimulated phosphatidylinositol 3-kinase-dependent endothelial cell migration and invasion. These results suggest, for the first time, that heparanase activates endothelial cells and elicits angiogenic responses directly. This effect appears to be mediated by as yet unidentified heparanase receptor.Journal of Biological Chemistry 06/2004; 279(22):23536-41. DOI:10.1074/jbc.M400554200 · 4.60 Impact Factor
Top Journals
Technion - Israel Institute of TechnologyH̱efa, Haifa, Israel
IEO - Istituto Europeo di OncologiaMilano, Lombardy, Italy


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How hard is it to progagate Liebeszauber - Kordes
Hi all,
I was not able to find this rose locally. This rose was a sleeper for me for three years.
This year it was amazing.
My most favorite roses out of my 200 roses.
But this year it was so beautiful, I have to have more!
I have my eye on propagating Liebeszauber, Kordes 1991. What should I expect?
Good results, lots of failures?
My experience with progation?, well, I had a bit of fun
with propagation some of my roses for the first time this year.
I don't know if they are going to make it over the winter
but it was fun. Thank You!
Good rose, Liebeszauber.
I started 3 HTs this past summer, two French and one English. Except for what the critters dug up, they have all (8) have been planted in the garden in groups of the same. The yellows will be the hardest hit by winter. Hopefully, they all come through. I don't often lose a rose.
That doesn't answer your question about Liebeszauber. However, there's no reason to believe you should have any trouble propagating it and overwintering it, its having been hybridized in a slightly colder climate.


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Danell Haspel: Be an Olympic expert in time for XXII Winter Games
The world is gearing up for the XXII Olympic Winter Games, which will be held in Sochi, Russia Feb. 7-23.
Be an expert on all things Olympic in time for the opening ceremonies.
Your library has a multitude of information on the topic, Olympic history, past Olympiads and the individual Olympic sports to get you or your child geared up and ready.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at email@example.com and we can help you.


text:
I am working with C# in Gtk, trying to show a number of widgets one above another in a scrolled window. I have a scrolledWindow containing a VBox set up.
Then, according to some logic in the application, I want to add a number of widgets to the VBox and have the scrolled window show them inside.
What I keep getting is that the scrolled window, instead of showing each widget properly, and the scroll bar on the side, is that all the widgets are stacked on top of each other, so they fir into the size of the scrolled window.
I have tried all kinds of expand/fill/packstart/packend combinations.
Any ideas anyone?
P.S. The widget I am adding is a (fairly) simple custom widget that contains a label and a button.


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Presidential Candidates Seem Indifferent to a Salary Rise
By DAVID STOUT
Published: May 30, 1999
WASHINGTON, May 29— The people who want to be President seem almost indifferent to an issue of public policy that could affect one of them personally: How much should the next chief executive be paid?
Despite repeated requests, fewer than half the candidates commented last week on a proposal in Congress to raise the pay of the President to $400,000. The salary has been $200,000 since Richard M. Nixon took office in 1969.
''Al Gore has spent his career in public service to help people, not to go after a pay raise,'' said Melissa Ratcliff, a spokeswoman for the Vice President.
Former Senator Bill Bradley, Mr. Gore's rival for the Democratic nomination, had a similar view. ''You don't run for this job for the annual salary,'' Mr. Bradley said through his spokesman, Tony Wyche. ''I think we should leave it up to Congress.''
The leading Republican candidate agreed entirely. ''It's the job of the Congress to decide,'' Gov. George W. Bush of Texas said through his spokeswoman, Mindy Tucker.
One of his rivals for the Republican nomination, former Gov. Lamar Alexander of Tennessee, also declined to involve himself in the debate. ''I shouldn't help to set the salary I will receive as President,'' Mr. Alexander said through his chief press aide, Bo Harmon.
Steve Forbes, another Republican candidate, opposes a raise for the next President, said his spokeswoman, Juleanna Glover Weiss. The wealthy Mr. Forbes, of course, does not have to worry about money.
Gary L. Bauer, a social and religious conservative, is regarded by pollsters as the longest of long shots for the Republican nomination, but on the issue of Presidential pay his views -- as far as they go -- are in line with those of his countrymen.
''I can tell you that Gary opposes doubling the President's salary all at once,'' Mr. Bauer's spokeswoman, Jessica Morris, said.
So do most Americans, according to a recent survey by the Pew Research Center for the People and the Press in Washington. Only one person in four thought the President's pay should rise by more than $20,000.
About two-thirds of those surveyed said the President should get a raise at least once a decade. Told that the President's pay had not gone up since 1969, 49 percent said the next one should get a raise while 39 percent said no.
But when those surveyed were told that the President now makes $200,000 (a fact only 19 percent of the respondents knew beforehand), plus $100,000 for travel and $50,000 for expenses, only 41 percent favored a raise, while 55 percent opposed one.
The survey was based on telephone interviews among a nationwide sample of 1,179 adults from May 12 through May 16 and had a margin of sampling error of plus or minus 4 percentage points.
The public's feelings notwithstanding, witnesses who appeared last week before a panel of the House Committee on Government Reform were ''nearly unanimous'' that the President's pay should go to $400,000, said Russell George, chief counsel and staff director of the Subcommittee on Government Management, Information and Technology.
Former Presidential aides who might agree on little else, politically or historically, were united in their view that the President's compensation (even with its many fringe benefits) ought to go up.
''This is not even a close call,'' said Kenneth Duberstein, a former chief of staff to President Ronald Reagan. ''This needs to be addressed now. It is a case of simple equity.''
Alexander M. Haig, onetime chief of staff to Nixon, agreed, as did John H. Sununu, who held the job under President George Bush, and Thomas F. McLarty 3d, former staff chief to President Clinton.
Mr. McLarty said that other high officials, unlike the President, are eligible for Congressionally approved cost-of-living increases but that those increases were becoming minimal out of fear that the pay of some officials would overtake the President's. For instance, the Vice President, the Chief Justice of the United States and the Speaker of the House make $175,400.
If Congress does not act on a Presidential raise in 1999, it may be even less likely to do so in 2000, since the pay of public officials is a sensitive issue to take up in an election year. If nothing is done before noon on Jan. 20, 2001, the next President will not get a raise.
Five Republican candidates, former Vice President Dan Quayle, Elizabeth Dole, Patrick J. Buchanan, Senator Robert C. Smith of New Hampshire and Representative John R. Kasich of Ohio, declined comment on whether the next person in the White House should be paid more.
But it is a safe bet that they agree with Governor Bush and former Governor Alexander on one point. ''He'd take the job either way,'' Ms. Tucker said of Mr. Bush.
''That's our position, too,'' Mr. Harmon said for Mr. Alexander.
Graph: ''DOLLARS AND SENSE: Presidential Pay'' Starting at $25,000 in 1789, the President's salary has been raised only four times. It was first raised to $50,000 for Ulysses S. Grant's second term. William H. Taft was the first beneficiary of the second raise; pay was raised again for Harry S. Truman's second term. Richard M. Nixon was the first to benefit from the most recent raise. *Figures for estimating inflation based on consumer prices start in 1913.


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Offer Sheet Matched. Weber signed to Nashville for 14 years
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Join Date: Jul 2012
Location: Smashville, TN
Posts: 1,578
vCash: 500
Originally Posted by
Preparing to pay a lot of money isn't the same as being able to predict an unprecedented offer of this type. It's funny how you could say there was no way of seeing Pearl Harbor or 9/11 when in both circumstances there were indicators that AN attack could happen but nothing that spelled out something of the magnitude of what we experienced .... yet you claim that Poile and the owners should then have foreseen the offer sheet equivalent. Yes, everyone knew an offer sheet COULD happen, but, I've yet to find a post on HF predicting Philly with the record bonus containing offer that requires $52,000,000 in bonus money alone between the signing of the contract and July 1st, 2015 (just under three years). Maybe I missed it somewhere.
The assertion of " more than likely low ball offers" is just more pure speculation on your part. The reports surrounding the Suter offer have the Preds in the $90,000,000 range before the Wild's final, and eventually successful, offer.
It is funny huh kinda of the same situation. The Preds knew and offer sheet could come just like the united states govt knew an attack could occur. Neither one could be predicted. Not sure on your point but i will play along.
Yes that is what i stated Poile and the owners should have seen an offer sheet coming for Weber. Why would someone predict the bonus money amount or contract? What would be the point not sure where you are going on that one either.
Maybe i missed it but if i was a GM of a team and Weber was on it i would expect if a team put in an offer sheet it would not be for market value or market worth. It would be a lot more and something to prevent me from matching. Maybe i am missing something but that is common sense to me.
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Published by 2K, Developed by Firaxis
Genres: Strategy
US release date: Dec 30th, 2008 | EU release date: -
Civilization Revolution has no review on Wii's World.
Steve said:
Do you control the citizens or fight against them?
Franksy said:
Sounds like you make avatars and play?
Ferox said:
Woohoo civilization for the Wii.
WolfKolf said:
Sid is the man.
InsertPageUp said:
I would rather have Black&White Revolution but this still sounds pretty cool.
Senpai said:
I thought Wii and the ds were getting civilization AND black and white?
Nintendojunkie said:
This looks freakin' good.
Jason said:
Wow. This looks like it will be amazing.
The Hamburgler said:
I love Civ. Hopefully they don't streamline the gameplay too hardcore. I have read that there will not be as many technological levels in the modern era.
CaliforniaOr Bust said:
Sounds great, but it sucks they put it on hold if you look under related news. Alas we won't get a true Civ/Wii experience yet.
Project Ukulele - Possible Hint at Characters
Could it be?
Free to Play Pokemon Shuffle now available on 3DS eShop
Nintendo offers another micro-transaction based title
Gold Mario Amiibo is a Wal-Mart Exclusive
Get ready to shell out your coins
Area Effect Announces Izle for Wii U
Part action, part adventure, all cel-shaded
Nintendo Confirmed As Sponsor For APEX 2015
Another positive step for the Smash competitive scene
Majora's Mask 3D Collector's Edition Contains Skull Kid Figurine
Pre-orders are now open!
Ackk Studios Rings in the New Year with New Y2K footage
Starting the New Year with a bang!
Is Nintendo Making A New Wii U Gamepad?
Recent commercial may have leaked new GamePad model
Zeldathon Relief Announced
Pot smashing for a great cause
Why the Inclusion of The Duck Hunt Dog in Super Smash Bros. Was Brilliant
How the the most hated character in video games rose to the top of the Smash heap
Planes: Fire & Rescue
Released on November 6th, 2014
The Voice: I Want You
Released on October 21st, 2014
Skylanders Trap Team
Released on October 5th, 2014
Wipeout: Create & Crash
Angry Birds Star Wars
Released on October 29th, 2013
Michael Jordan said:
No they're making it from the movie ... Speed Racer: The Video Game
daveoneal said:
Thanks Rob. I had no idea this one was published. I'm very happy about it! Yes, Jonathan, it is hard as all get-out, ... Street Fighter 2010: The Final Fight review
daveoneal said:
This was a very well-written review. Apparently Super Hexagon was developed by Terry Cavanagh (who made vvvvvv), so ... Cosmophony review
dirk said:
:p p ... TMNT: Smash Up
dirk said:
cool :p ... TMNT: Smash Up
Wii's World is not officially affiliated with Nintendo! (but they wish we were).


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text:
I know car seats have expiration dates but do other baby things have them...like swings and vibrating chairs and such? I don't plan on having my next child anytime soon (I want to wait about 5 years). So, I'm debating on putting stuff in storage when this lo is done with it and pulling it out later, or giving stuff away to friends that will be having babies. Also, how long do you use swings for?? DH says when lo starts using a bouncer walker thing he will no longer need the swing...is this true?? I'm mostly concerned about the swing. I love it. but, if it's not going to work in 5 years, then I'd rather give it to someone else that can use it. what would you do?
expiration dates on baby stuff
Posted 08/11/2014
I've never heard of there being expiration dates on this kinda stuff!! Only size/weight/age restrictions.....I've kept everything for my next baby lol might have to buy new stuff if it's a girl haha
Comet87 · Original Poster
Posted 08/11/2014
That's the best part.... Pretty much everything I have is gender neutral
Posted 08/11/2014
I am thinking the same but i will sell eveything and if i have another in 5 years buy new. In 5 years nee things appear an as everythin is almost new i can sell it at a good price
Posted 08/11/2014
Lol I knew I was having a boy from about 15weeks, I had such a strong feeling I bought everything for a boy and I was RIGHT lol. To be honest the only thing I would buy new if I have a girl is clothes lol
Comet87 · Original Poster
Posted 08/11/2014
I wanted everything gender neutral. Everything except clothes that is. I didn't want to fall into any gender stereotypes.
Last edited 08/11/2014
I've used all the same stuff from my first who is almost 4 (except the car seat). The swing I have is one we bought to take care of my friends now 6 year old so it's seen 3 babies and 6 years and still works great. Sure new models of everything come out in that time but really they all do the same essential thing. Just anything that has a battery pack take it out before storing. Updated for type-os
Posted 08/11/2014
So are you suppose to get a new carseat with each child? Or is there an actual length of time carseats last??
Posted 08/11/2014
It's usually five years, but there is an actual date printed on the seat somewhere. If you can't find it, go to the manufacturer's website and look up where it's supposed to be.
Swings and such don't need to resist impacts at 60mph, so they don't expire. So long as it's not broken, you can use an old one.
Swings and such don't need to resist impacts at 60mph, so they don't expire. So long as it's not broken, you can use an old one.
Posted 08/11/2014
You can keep using those. My swing is 10 years old already that a coworker gave us. Works great its just not as cute as the ones out now LOL.
Posted 08/11/2014
As far as when to no longer us the swing: if the baby can sit up its no longer safe to use swings or bounce chairs as they can come off balance if the baby sits up.
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Your growing child
Your 10-month-old: Week 1
Your baby is just beginning to understand many simple words and phrases, so it's more important than ever to keep talking to him. Give your chatterbox a head start on good speech patterns by repeating his words back to him using adult language. Read More
Your 10-month-old: Week 2
At this age, your baby can sit confidently and may even walk while holding onto furniture, possibly letting go momentarily and standing without support. Read More
Your 10-month-old: Week 3
Your baby may "walk" while you're gripping his hands, and even hold out an arm or leg to help you dress him. Read More
Your 10-month-old: Week 4
Your baby now understands simple instructions, although you may still be ignored when you say "no." (To help the word carry a little more weight, use it sparingly, for setting important limits.) Read More


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33 year old woman | Silver Spring, MD, USA | Seeking men 25-37 within 50 miles of Randallstown, MD
Does Prince Charming exist?
I am not a fan of writing or talking about myself. I feel as though I am filling out a resume about me. I am looking for someone who is kind and compassionate. Someone who will respect me and treat me like a lady. I enjoy nice things but not a princess or expect the best. Don't want to put too much down here cause I enjoy talking with someone and if I put everything down you will know all about me and will have nothing to ask me. So start thinking of those questions and email me :-)
Camping , Cooking , Hobbies and crafts , Movies/Videos , Music and concerts , Playing sports , Travel/Sightseeing , Watching sports , Wine tasting
Aerobics, Baseball, Bowling, Dancing, Football, Running, Skiing, Swimming, Walking / Hiking, Yoga
I exercise 1-2 times per week.
I like Cats, Dogs, Fish
Some other viewpoint
Going out with friends in the Baltimore area and DC sometimes. I also enjoy chilling on the couch with a glass of wine and movie. Love being outdoors in the summer.
Towson University, Towson, MD
Wow, lets see.....I work too much sometimes which probably has not helped in relationships, but if I find that right person work wont be so demanding for me. I love laughing and smiling. I will try almost anything once. I enjoy the arts.
I love to read and try to read one book a month.
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|5'3" (160cms)
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|Associates degree, Bachelors degree, Graduate degree, PhD / Post Doctoral


text:
Rittal updates DET-AC III product range for fire detection and extinguishing
Rittalcontact supplier
DET-AC III range
Rittal has updated the DET-AC III product range, comprising the DET-AC III master fire alarm and extinguisher system, the complementary DET-AC III slave unit and the EFD III early fire detection solution. All three products are available in the form of 19in slide-in racks.
Significant enhancements have been made to the DET-AC III master. The system now features a CAN bus interface for direct integration with the Rittal CMC (computer multi-control) III monitoring solution. This provides administrators with more detailed information on the status of installations and incoming alerts.
A USB interface is said to simplify service and maintenance of the DET-AC III. It allows service technicians to view information on operational status and events, modify configurations, reset service intervals or install new firmware from a laptop, without opening the enclosure.
Taking up 1U in a 19in rack featuring a two-stage smoke extraction system, two highly sensitive optical sensors detect small smoke particles at early stages and can sound an alarm from 0.25 per cent obscuration per meter. If the first sensor detects smoke aerosols, a pre-alarm is issued. If the second sensor also detects smoke, the main alarm is triggered and the extinguisher is activated.
Using the 3M Novec 1230 fire suppression solution, the system was the first in its class to successfully pass comprehensive VdS testing. It is environmentally friendly, does not conduct electricity and does not damage IT equipment.
More stories
Rittal's Therm software simplifies calculation of enclosure cooling and heating requirements weblink
Rittal's Therm 6.3 software is designed to simplify the often time-consuming and complicated calculation of enclosure cooling and heating requirements.
Rittal's EC fan-and-filter units with speed control help to ensure energy efficiency weblink
According to Rittal, its fan-and-filter units with EC (electronically commutated) motors should be the preferred choice for energy efficiency in enclosure climate control, as their operating ratio is significantly higher than standard AC fan-and-filter units.
Rittal introduces RiLine busbar system for AC and DC applications downloadweblink
Efficient drive systems, idle power loss reductions and the renewable energy sector all require safe, reliable DC solutions and, while they cannot replace AC applications across the board, they are definitely growing in importance. Rittal is offering an approved busbar system with standard components, optimised for both AC and DC applications. No other products are required.
Rittal expands modular TS IT rack to offer more than 100 configurations weblink
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RPE 6.2 software supplies current-carry capacity of all leading ACB manufacturers weblink
For switchgear with ratings above 1,600A, air circuit breakers (ACBs) and copper connections have to be tested for short circuit and the effects of heat rise. Rittal's latest RPE software (version 6.2) can supply the actual current-carry capacity (Inc) of all leading ACB manufacturers, plus the CAD drawings of the ACB connections required to fit within the Ri4Power modular switchgear systems.