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Publications (88)118.98 Total impact
Article: Investigation of nano SiO2 impact on mechanical and biocompatibility Properties of Cyanoacralate based nanocomposites for dental application[Show abstract] [Hide abstract]
ABSTRACT: Although cyanoacrylate glues are widely used in medicine, cyanoacrylate based nanocomposites have been recently suggested for dental restorative/filling applications. In the present research, SiO2 nanoparticles were used as filler for development of a novel dental nanocomposite base on alkoxy-ethyl-cyanoacrylate. The nanocomposite samples filled with different levels of nano-sized SiO2 (wt %) were made the mechanical properties were evaluated and comparisons were made with the neat cyanoacrylate. The hardness and wear behavior of the samples were measured using Vickers hardness and pin-on-disk tester, respectively. The wear mechanism of the samples was also evaluated using scanning electron microscopy (SEM). Furthermore, cell biocompatibility of the samples using MTT and LDH assays as well as inflammatory cytokine expression interleukin-6 (IL-6) from L929 cells were investigated. The results showed that an increase in nano-sized SiO2 content improves hardness and wear resistance of the cyanoacrylate based nanocomposites and changes the wear mechanism from adhesive to abrasive. The results of cytotoxicity analysis showed a significant reduction in cell viability and IL-6 produced from the samples-exposed L929 cells compared with untreated control cells. Moreover, increasing in nano SiO2 powder content caused a decrease in the released formaldehyde.International Journal of Adhesion and Adhesives 10/2014; 54. DOI:10.1016/j.ijadhadh.2014.06.004 · 2.22 Impact Factor
Article: Protective effects of Scutellaria lindbergii root extract against oxidative-induced cell and DNA damage in mouse fibroblast-like cells.[Show abstract] [Hide abstract]
ABSTRACT: Abstract Context: Scutellaria lindbergii Rech. f. (Lamiaceae) is an Iranian species of Scutellaria which has been shown to exert antimicrobial, antioxidant and cytotoxic effects. Objective: The protective properties of total methanol extract (TME) of S. lindbergii and its fractions (defatted and CH2Cl2) were investigated against cytotoxic and genotoxic effects of H2O2 in NIH 3T3 cell line as non-malignant cells. Materials and methods: The cells were incubated with different concentrations of S. lindbergii root extracts [TME (15-250 μg ml(-)(1)), defatted fraction (15-500 μg ml(-)(1)) and CH2Cl2 fraction (5-40 μg ml(-)(1))] and toxic concentration of H2O2 (200 µM) at 37 °C for 2 h concurrently and Cell viability was quantitated by MTT assay. The antigenotoxic effect of extracts was investigated using comet assay. The cells were incubated with extracts [TME (25-250 μg ml(-)(1)), defatted fraction (25-500 μg ml(-)(1)) and CH2Cl2 fraction (5-40 μg ml(-)(1))] and H2O2 (25 µM) at 4 °C for 20 min, then the comet assay was performed. DNA damage was expressed as percentage tail DNA. Results: Total methanol extract of S. lindbergii and its fractions had a significant inhibitory effect on DNA damage. The IC50 values of TME, defatted fraction and CH2Cl2 fraction against DNA damage were determined as 48, 138 and 8 μg ml(-)(1), respectively. Conclusion: S. lindbergii extracts can prevent oxidative DNA damage, which is likely due to its flavonoids and phenolic compounds as antioxidant constituents.Drug and Chemical Toxicology 09/2014; DOI:10.3109/01480545.2014.954047 · 1.10 Impact Factor
Article: Evaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes.[Show abstract] [Hide abstract]
ABSTRACT: Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F. szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human lymphocytes.Avicenna Journal of Phytomedicine 09/2014; 4(5):337-42.
Article: In vitro protective effects of Scutellaria litwinowii root extract against H2O2-induced DNA damage and cytotoxicity.[Show abstract] [Hide abstract]
ABSTRACT: Abstract Background: Despite the wide range of investigations on the therapeutic potentials of herbal extracts in cancer cell lines, there is not usually enough data on their probable effects on normal cells. Recently, both anti-tumoral and anti-oxidant properties of Scutellaria litwinowii extracts have been reported on different cancer cell lines. In the present study, the possible protective effects of S. litwinowii root extracts against cytotoxicity and DNA damage induced by hydrogen peroxide (H2O2) on normal cells were investigated using MTT and Comet assays, respectively. Methods: A method of sequential extraction with solvents of different polarities was used to generate methanolic, de-fatted, and dichloromethane fractions. Both MTT and Comet assays were performed here to assess, respectively, changes in cell viability and levels of DNA damage from H2O2. In a pre-treatment regimen, test materials were applied to the cells prior to H2O2 treatment, while in a co-treatment protocol, cells were treated simultaneously with H2O2 and extracts. Results: In the co-treatment studies, only methanolic extract at 1,000 μg/mL (p<0.001) imparted a significant protective effect as shown in the MTT assay. Pre-treatment of cells for 24 h with different concentrations of the test materials did not lead to any significant protection. Results from the Comet assays in the co-treatment studies suggested a significant (p<0.01) protective effect of the test materials against DNA damage caused by H2O2. However, in the pre-treatment studies, only methanolic extract at ≥500 μg/mL showed a protective effect (p<0.01). Conclusions: Considering the probable high levels of phenolic and flavonoid compounds in the methanolic extract, these compounds may impart the noted protective effects of the S. litwinowii root through the scavenging of free radicals.Journal of Complementary and Integrative Medicine 04/2014; DOI:10.1515/jcim-2014-0009
Article: Protective effects of aqueous and ethanol extracts of rosemary on H2O2-induced oxidative DNA damage in human lymphocytes by comet assay.[Show abstract] [Hide abstract]
ABSTRACT: Abstract Background: Rosemary (Rosmarinus officinalis) possesses various pharmacological properties such as antioxidant, anti-tumorigenesis and anti-mutagenesis activities. In this study, we investigated the possible protective effects of ethanol and aqueous extracts of rosemary on human lymphocyte DNA damage induced by H2O2. The extent of DNA lesions was measured using comet assay. Methods: Blood samples were taken from healthy volunteers and lymphocytes were isolated. The lymphocytes were then incubated in aqueous and ethanol extract of rosemary (0.05, 0.1, 0.5, 1 and 2.5 mg/mL) and H2O2 (50, 100 and 200 mM). Lymphocytes were also incubated with a combination of H2O2 (100 mM) with either 1 or 2.5 mg/mL of both extracts for 30 min at 4°C. Results: Our findings showed that H2O2 treatment led to a significant concentrate-dependent DNA damage in human lymphocyte when compared to respective controls (p<0.001). The DNA damage which was initially occurred as the result of 100 µM H2O2 (Percentage tail DNA 55.1%) was inhibited due to the ethanol extract of rosemary at the doses tested (percentage tail DNA 4.7% and 4.03%). However, the aqueous extract has no effects on H2O2 genotoxicity. Conclusions: We suggest that antioxidant constituents in ethanol extract of rosemary can prevent human lymphocytes oxidative DNA damage which is due to its free radical scavenging activity.Journal of Complementary and Integrative Medicine 02/2014; DOI:10.1515/jcim-2013-0063
Article: Assessment of protective effects of glucosamine and N-acetyl glucosamine against DNA damage induced by hydrogen peroxide in human lymphocytes[Show abstract] [Hide abstract]
ABSTRACT: Abstract The antigenotoxic activity of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human peripheral lymphocytes exposed to oxidative stress was investigated. Human lymphocytes were treated with different concentrations of these aminosugars (0, 2.5, 5, 10, 20 and 40 mM) and 25 µM H2O2 simultaneously and evaluated by single cell gel electrophoresis technique (Comet assay). The single cells were analyzed using "TriTek Cometscore version 1.5" software and the data were presented as % DNA in tail. Both GlcN and GlcNAc at examined concentrations (2.5, 5, 10, 20 and 40 mM) did not reveal any genotoxicity compared to the vehicle control (PBS). Glucosamine at all concentrations (2.5, 5, 10, 20 and 40 mM) showed a significant protective activity (% DNA in tail ranging from 16.07 ± 0.85 to 5.47 ± 0.26, p < 0.001) against H2O2 induced DNA damage (% DNA in tail = 38 ± 0.65) while its N-acetylated analog only indicated a slight DNA protection at concentration of 40 mM (% DNA in tail = 33.4 ± 1.17, p < 0.01). We concluded that GlcN at tested concentrations exhibited potent antigenotoxic effect and its protection activity might be related to the presence of 2-NH2 moiety in its chemical backbone.Drug and Chemical Toxicology 01/2014; 37(4). DOI:10.3109/01480545.2013.878951 · 1.10 Impact Factor
Article: Pathodiagnostic parameters and evaluation of O(6)- methyl guanine methyl transferase gene promoter methylation in meningiomas.[Show abstract] [Hide abstract]
ABSTRACT: Histopathological evaluation and grading of meningioma give important prognostic information. We evaluated retrospectively monotonous sheeting, necrosis, hypercellularity, nuclear pleomorphism, small cell changes, brain invasion, mitosis, mast cells, psammoma bodies, MIB-1 labeling index (MIB-1 LI) and histological grade of 230 primary meningioma tumors according to the latest World Health Organization (WHO) classification. To reveal any possible association between clinical features and promoter hypermethylation of O(6)-methylguanine-DNA methyltransferase (MGMT) as an important epigenetic modification in many human cancers, we also evaluated the methylation status of MGMT in meningiomas by a SYBR-green-based real-time PCR method. There was a female predominance (2.38 to 1) in the meningiomas. The mean age of the patients was 49.9 ± 12.6 years (range 16 to 78 years). Transitional meningiomas were the most common subtype of the meningiomas (35.21%, n = 81). Most of the meningiomas were located in the falx and parasagital area. There was a significant correlation between histopathological features of malignancy. These features were observed more frequently and with statistical relation to grade II rather than grade I. Mast cells, psammoma bodies and nuclear pleomorphism had poor associations (P > 0.05). When we re-evaluated the tumor grading, 31 patients with grade I meningiomas were upgraded to grade II. None of the meningiomas tested by MSQP were methylated in MGMT promoter sequence. High MIB-1 LI could be indicative for higher grade of meningioma. Continuous revision of the classification system is needed to improve the accuracy of prognostic judgments in meningioma. The data confirm that there is no rationale to test meningiomas for MGMT methylation status.Gene 01/2014; DOI:10.1016/j.gene.2013.12.039 · 2.20 Impact Factor
Article: Celecoxib Up Regulates the Expression of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines.[Show abstract] [Hide abstract]
ABSTRACT: Elevated expression of the drug efflux transporter ABCG2 seems to correlate with multidrug resistance of cancer cells. Specific COX-2 inhibitor celecoxib has been shown to enhance the sensitivity of cancer cells to anticancer drugs. To clarify whether ABCG2 inhibition is involved in the sensitizing effect of celecoxib, we investigated whether the expression of ABCG2 in breast cancer cell lines, could be modulated by celecoxib. The expression of the multidrug resistant gene (ABCG2) at mRNA and protein level was detected by real-time quantitative reverse transcription-polymerase chain reaction and flow cytometry analysis, respectively. Among three human breast cancer cell lines ABCG2 and COX-2 were highly expressed in MCF7-MX and MDA-MB-231 cells, respectively. The COX-2 inhibitor celecoxib up-regulated the expression of ABCG2 mRNA in MCF-7 and MCF7-MX cells, which was accompanied by increased ABCG2 protein expression. While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level. Our findings provide evidence that celecoxib up-regulates ABCG2 expression in human breast cancer cells and proposed that ABCG2 is not involved in chemosensitizing effects of celecoxib.Iranian journal of pharmaceutical research (IJPR) 01/2014; 13(4):1393-401. · 0.51 Impact Factor
Article: Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress.[Show abstract] [Hide abstract]
ABSTRACT: Abstract The antigenotoxic effects of umbelliferone (UMB), herniarin (HER) and 7-isopentenyloxy coumarin (7-IP), common natural dietary coumarins, were evaluated on the human lymphocyte DNA damage using single-cell gel electrophoresis. H2O2-induced DNA break was measured based on the percentage of DNA in tail, and the antigenotoxic effects of the tested compounds were compared with that of ascorbic acid (10, 25, 50, 100 and 200 μM). UMB, HER and 7-IP did not show any genotoxicity, as compared to phosphate-buffered saline. Treatment with UMB, HER and 7-IP led to a significant reduction in the percentage of DNA in tail induced by H2O2 (p < 0.001) at all concentrations. The presence of prenyl moiety in the chemical structure of 7-IP may contribute to its better antigenotoxic property, compared to UMB. The results of this study showed that 7-IP possessed the best antigenotoxic activity among the tested compounds.Drug and Chemical Toxicology 10/2013; 37(2). DOI:10.3109/01480545.2013.834352 · 1.10 Impact Factor
Article: Evaluation of Antibacterial Activity of the Essential Oils of Zataria multiflora, Carum copticum and Thymus vulgaris by a Thin Layer Chromatography-Bioautography Method[Show abstract] [Hide abstract]
ABSTRACT: Bioautography is a method to localize antimicrobial activity on a chromatogram. A modified agar overlay bioautographic method was used to investigate the antibacterial activities of essential oils of Zataria multiflora, Carum copticum and Thymus vulgaris. The essential oils of all the plants exhibited activity against Bacillus subtilis and Escherichia coli at R F ~ 0.4 which represented the R F for Thymol and carvacrol in petroleum ether chloroform (50:50 as solvent system). Twenty two components were identified in the essential oil of Carum copticum. The main compounds consisted of Thymol (71.07%), terpinolene (13.08%) and cymene (10.20%). It could be concluded that the observed antibacterial activity was mainly due to the presence of Thymol and carvacrol in the essential oils.Journal of essential oil-bearing plants JEOP 03/2013; 10(3):259-264. DOI:10.1080/0972060X.2007.10643551 · 0.19 Impact Factor
Article: Chemical Composition, Moderate In Vitro Antibacterial and Antifungal Activity of the Essential Oil of Pistacia vera L. and it's Major Constituents[Show abstract] [Hide abstract]
ABSTRACT: The composition and antimicrobial activity of the essential oil of Pistacia vera L., grown in Iran, was studied. The oil was obtained from the resin and analyzed by GC-MS. Twenty compounds, accounting for 99.5 % of the total components, were identified. The main constituents were α-pinene, β-pinene , and α-thujene. The antimicrobial effects of the essential oil of Pistacia vera L. gum and its major constituents ((+)α-pinene, (-)α-pinene, (-)β-pinene, (-)α-thujene and α, β-thujene) were investigated. Antibacterial assays were performed using broth microdilution assays to determine the minimum inhibitory concentrations (MICs) against two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis) and three Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiela pneumoniae). The antifungal activity against Candida albicans was determined by the agar dilution method. The essential oil of Pistacia vera L. gum exhibited strong inhibitory effects against Gram positive bacteria and C. albicans. Moreover, The results indicated that (-)β-pinene had the most inhibitory effects against Gram positive bacteria and C. albicans while α, β-thujene was more active against Gram negative bacteria.Journal of essential oil-bearing plants JEOP 03/2013; 11(4):376-383. DOI:10.1080/0972060X.2008.10643643 · 0.19 Impact Factor
Article: Composition, Antimycotic and Antibacterial Activity of Ziziphora clinopodioides Lam. Essential Oil from Iran[Show abstract] [Hide abstract]
ABSTRACT: The essential oil components of Ziziphora clinopodioides Lam. from Iran were isolated via hydrodistillation and analyzed by GC-MS. Twenty seven components were identified in the essential oil of the plant. The main compounds consisted of pulegone (44.5 %), terpineol (14.5%) methyl acetate (10.9%), iso-neomenthol (7.1%) and 1, 8-cineole (4.1%). Antifungal and antimicrobial acitivities of different concentrations of the essential oil of Ziziphora clinopodioides Lam. was also evaluated. The antifungal tests were conducted by a poisoned food technique against the filamentous fungi (Aspergillus niger, Trichophyton rubrum, Trichoderma reesei and Microsporum gypseum). antimicrobial tests were carried out against four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Klebsiella pneumonia) and one Gram positive pathogen (Staphyloccocus aureus) using a microdilution assay. The essential oil was found to be fungicidal at >1 μl/ml against T. rubrum and M. gypseum. The minimum inhibitory concentration of the oil against Escherichia coli, Staphyloccocus aureus, Pseudomonas aeruginosa, Salmonella typhi and Kleb-siella pneumonia were found to be 0.003, 0.033, 0.033, 0.067 and 0.067 % (v/v) respectively.Journal of essential oil-bearing plants JEOP 03/2013; 10(4):339-345. DOI:10.1080/0972060X.2007.10643565 · 0.19 Impact Factor
Article: Cytotoxic and Antimycotic Activities of Essential Oil of Artemisia turanica Krasch from Iran[Show abstract] [Hide abstract]
ABSTRACT: The cytotoxic and anti-fungal activities of Artemisia turanica essential oil were investigated. Also the composition of the essential oil of the plant was determined. For cytotoxic activity tests, a potato disc tumor inhibition method was exploited. For antifungal activity tests, a poisoned food technique against standard strains of Trichophyton rubrum, Trichoderma reesei, Microsporum gypseum and Aspergillus niger was adopted. The essential oils of A. turanica exhibited tumor growth inhibition (100 % ) inhibition at concentrations equal to 0.02 % (w/v) and higher. Thirteen components were identified in the essential oil of Artemisia turania. The main compounds consisted of 1,8-cineol (40.9 %), cis-verbenyl actate (19.0 %) and camphor (11.0 %). A dose activity relationship between the essential oil concentrations with inhibition of tumor growth on potato discs, and between the essential oil concentrations with antifungal activities was observed.Journal of essential oil-bearing plants JEOP 03/2013; 9(2):196-203. DOI:10.1080/0972060X.2006.10643492 · 0.19 Impact Factor
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ABSTRACT: In this study, a methanolic extract and an essential oil of Artemisia kopetdaghensis were tested for possible Cytotoxic activity using potato disk assay. Seven concentration of methanolic extract and four concentration of the essential oil were applied on potato discs. The methanolic extract and essential oil of A. kopetdaghensis exhibited tumor growth induction at different concentrations but at concentration equal to 0.01 % (v/v) the essential oil of A. kopetdaghensis exhibited tumor growth inhibition (52 %). A dose activity relationship between methanolic extract and essential oil concentration with tumor growth on potato discs was observed.Journal of essential oil-bearing plants JEOP 03/2013; 13(6):732-737. DOI:10.1080/0972060X.2010.10643887 · 0.19 Impact Factor
Article: The effect of temperature on antibacterial activity of biosynthesized silver nanoparticles.[Show abstract] [Hide abstract]
ABSTRACT: The purpose of this study was the evaluation of two different temperatures on antibacterial activity of the biosynthesized silver nanoparticles. 38 silver nanoparticles-producing bacteria were isolated from soil and identified. Biosynthesis of silver nanoparticles by these bacteria was verified through visible light spectrophotometry. Two strains were relatively active for production of silver nanoparticles. These strains were subjected for molecular identification and recognized as Bacillus sp. and Acinetobacter schindleri. In the present study, the effect of temperatures was evaluated on structure and antimicrobial properties of the silver nanoparrticles by transmission electron microscopy (TEM), X-ray diffraction (XRD) analysis and antimicrobial Agar well diffusion methods. The silver nanoparticles showed antibacterial activity against all the pathogenic bacteria; however, this property was lost after treatment of the silver nanoparticles by high temperatures (100 and 300 °C). TEM images showed that the average sizes of heated silver nanoparticles were >100 nm. However, these were <100 nm for non-heated silver nanoparticles. Although, XRD patterns showed the crystalline structure of heated silver nanoparticles, their antibacterial activities were less. This was possible because of the sizes and accordingly less penetration of the particles into the bacterial cells. In addition, elimination of the capping agents by heat might be considered another reason.Biology of Metals 01/2013; DOI:10.1007/s10534-012-9606-y · 2.69 Impact Factor
Article: An investigation on the wear properties and cytotoxicity of cyanoacrylate based nanocomposite in dentistry[Show abstract] [Hide abstract]
ABSTRACT: امروزه چسبهاي سيانواكريلات كاربردهاي گستردهاي در پزشكي و دندانپزشكي پيدا كردهاند. هدف پژوهش حاضر، بررسي نقش بر رفتار سايش چسب سيانواكريلات در محيط شبيه سازي شده بزاق مصنوعي ميباشد. رفتار سايش سيانواكريلات SiO نانو ذرات 2 توسط آزمون سايش ميله بر صفحه مطالعه شده و مكانيزم سايش نمونه ها با استفاده از تصاوير SiO با مقادير متفاوت نانو ذرات 2 مورد بررسي قرار گرفته است. علاوه بر اين، تغييرات در ميزان سختي، دماي افت جرم ناشي از تخريب حرارتي و ميز ان SEM حرارت آزاد شده در اثر خودگيري مورد مطالعه قرار گرفته است. همچنين به منظور بررسي زيست سازگاري اين مواد ، آزمون 1 انجام شده است. نتايج نشان داده اند كه MTT با استفاده از روش L سميت سلولي بر روي سلولهاي فيبروبلاست لثه موش رده 929 افزايش در ميزان نانوذرات تقويت كننده در كامپوزيت زمينه سيانواكريلات، منجر به افزايش مقاومت به سايش و سختي سيانواكريلات شده و افزايش دما ناشي از خودگيري چسب را بهشدت كاهش ميدهد. علاوه بر اين، كامپوزيت حاصله درجات پائينتري از سميت سلولي نسبت به پايه سيانواكريلات خود نشان ميدهد
Article: Glucokinase gene promoter -30G>A polymorphism: a cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE: A -30G>A single nucleotide polymorphism in the promoter region of the glucokinase gene has been previously associated with obesity, insulin resistance and diabetes. The present study aimed to evaluate the association of this polymorphism with obesity and its comorbidities in a population from Northeast Iran. METHODS: Five hundred and forty-two subjects aged 18 to 65 years were included in the study and divided into normal (BMI<25, n=220), overweight (25<BMI<30, n=135) and obese (BMI>30, n=187) groups. All subjects were genotyped for the -30G>A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The genotypes and allele frequencies of the three groups did not differ significantly (p>0.05). When the study population was categorized according to diabetes mellitus, hyperlipidemia, hypertension and metabolic syndrome status, no significant difference in -30G>A genotypes and alleles was found between the subgroups with and without these disorders (p>0.05), apart from a significantly higher frequency of the G allele in the hyperlipidemic vs. non-hyperlipidemic subgroup (p<0.05). CONCLUSION: The findings of the present study do not support an association between the -30G>A polymorphism and high body mass index in the Iranian population.Revista de Nutrição 08/2012; 25(4):487-495. DOI:10.1590/S1415-52732012000400006 · 0.35 Impact Factor
Article: Biological Synthesis of Silver and Gold Nanoparticles by Bacteria in Different Temperatures (37°C and 50°C)[Show abstract] [Hide abstract]
ABSTRACT: Major purpose of this study was to investigate the effect of two temperatures of 37°C and 50°C on biosynthesis of extracellular silver and gold nanoparticles by some bacteria. To perform biosynthesis of nanoparticles, the bacterial culture supernatants of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus cereus, Escherichia coli, Klebsiella pneumonia and Yersinia enterocolitica were treated with aqueous solutions of silver nitrate (25 µL of 1 M) and gold III chloride ions (25 µL of 1 M) and incubated in shaker incubators (at 150 rpm) at 37°C and 50°C. Nanoparticles of silver and gold in the culture were monitored through UV-visible spectrophotometry and confirmed by X-ray diffraction analysis (XRD). The average size and morphology of nanoparticles were determined by transmission electron microscopy (TEM). The results obtained indicated that silver and gold nanoparticles were produced in the bacterial culture supernatants within 24 hr and the rate of production was relatively more at 50°C. XRD analysis confirmed biosynthesis of nanoparticles and UV–visible spectra showed maximum absorption for silver and gold nanoparticles at 410-430 and 510-540 nm respectively. In addition, TEM images illustrated the average size of nanoparticles from 10 to 80 nm. Overall, biosynthesis of nanoparticles is a simple method and does not require more time. In addition, some bacterial stains could produce reductive enzymes for reduction of silver and gold ions and this bioreduction could be affected by temperatures.Journal of Pure and Applied Microbiology 07/2012; 6(2):757-763. · 0.07 Impact Factor
Article: Phorbol Ester TPA Modulates Chemoresistance in the Drug Sensitive Breast Cancer Cell Line MCF-7 by Inducing Expression of Drug Efflux Transporter ABCG2[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have indicated a link between levels of cyclooxygenase-2 (COX-2) and development of the multidrug resistance (MDR) phenotype. The ATP-binding cassette sub-family G member 2 (ABCG2) is a major MDR-related transporter protein that is frequently overexpressed in cancer patients. In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines. ABCG2 mRNA and protein expression was studied using real-time RT-PCR and flow cytometry, respectively. A significant increase of COX-2 mRNA expression (up to 11-fold by 4 h) was induced by TPA in MDA-MB-231 cells, this induction effect being lower in MCF-7 cells. TPA caused a considerable increase up to 9-fold in ABCG2 mRNA expression in parental MCF-7 cells, while it caused a small enhancement in ABCG2 expression up to 67 % by 4 h followed by a time-dependent decrease in ABCG2 mRNA expression in MDA-MB-231 cells. TPA treatment resulted in a slight increase of ABCG2 protein expression in MCF-7 cells, while a time-dependent decrease in ABCG2 protein expression was occurred in MDA-MB-231 cells. In conclusion, based on the observed effects of TPA in MDA-Mb-231 cells, it is proposed that TPA up-regulates ABCG2 expression in the drug sensitive MCF-7 breast cancer cell line through COX-2 unrelated pathways.Asian Pacific journal of cancer prevention: APJCP 06/2012; 13(6):2979-84. DOI:10.7314/APJCP.2012.13.6.2979 · 1.50 Impact Factor
Article: PXR and NF-κB correlate with the inducing effects of IL-1β and TNF-α on ABCG2 expression in breast cancer cell lines.[Show abstract] [Hide abstract]
ABSTRACT: In this study we aimed to evaluate PXR and ABCG2 gene expression patterns and NF-κB activity induced by proinflammatory cytokines in different breast normal and carcinoma cells. The effects of proinflammatory cytokines on ABCG2 and PXR mRNA expression were studied using real-time PCR. Western blot analysis used for evaluating the protein levels of ABCG2, PXR and the active form of NF-κB (p65 in nuclear protein extract). Significant inductions in the ABCG2 and PXR mRNA and protein levels and NF-κB activity, were observed in MCF7, BT-474, CAL51, 184A1 and HBL100 cells, upon treatment with 50 ng/ml of IL-1β and TNF-α. On the contrary significant reduction of the ABCG2 and PXR mRNA and protein levels and NF-κB activity, were observed in MDA-MB-435 cell line. In conclusion, IL-1β and TNF-α induced ABCG2 and PXR expression and NF-κB activity in some breast cancer and normal cell lines. Similar patterns of induction and reduction in PXR and ABCG2 genes and NF-κB activity suggest a probable relationship between ABCG2, PXR and NF-κB.European journal of pharmaceutical sciences: official journal of the European Federation for Pharmaceutical Sciences 06/2012; 47(2):474-80. DOI:10.1016/j.ejps.2012.06.011 · 2.61 Impact Factor
Top Journals
Mashhad University of Medical Sciences
Mashad, Razavi Khorasan, Iran
- • Biotechnology Research Center
- • Immunology Research Center
- • Pharmaceutical Research Center
Avicenna Research InstituteTeheran, Tehrān, Iran
University of TorontoToronto, Ontario, Canada


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Monaco Government Tourist and Convention Office
7 Upper Grosvenor Street
London W1K 2LX
Tel : +44 (0)207 491 4264
Fax : +44 (0)207 408 2487
The great Tom Jones will perform live in concert on stage at the Salle des Etoiles on Saturday 16 August 2014
In his home country, he is known as "Jones The Voice." Each of the hits by this Welsh singer has taken popular music to a new level.
From pop to rock, country to soul and even dance music, Tom Jones is interested in all musical styles.
Renowned for songs such as "It's Not Unusual," "Kiss," "Delilah," "What's New Pussycat?," "I'll Never Fall in Love Again," and "If I Only Knew," he is above all a Rhythm & Blues artist at heart.
In 1999, he released the album "Reload," which remains the most-sold work (5 million copies) of his 35-year career. That same year, Rock & Folk magazine named him "Artist of the Millennium."
Tom Jones Concert – Saturday 16 August 2014
Monte-Carlo Sporting Summer Festival 2014
Salle des Etoiles, Sporting Monte-Carlo
Number of views : 219
The Ballets de Monte-Carlo Present "Roméo et Juliette" ("Romeo and Juliet") at the Grimaldi Forum
The 31st Monte-Carlo Spring Arts Festival ("Printemps des Arts") Continues from 2 to 5 April 2015
Free Admission to the New National Museum of Monaco on Sundays
Robbie Williams Concert to Celebrate the Tenth Anniversary of the Reign of Prince Albert II
7 Upper Grosvenor Street
London W1K 2LX
Tel : +44 (0)207 491 4264
Fax : +44 (0)207 408 2487

subset: commoncrawl


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Mobile, mobile-only, mobile apps, smartphones: Enough said
The newly released annual look at the digital world from online and mobile measurement firm comScore makes it quite clear that retailers better be ...
Mobile, mobile-only, mobile apps, smartphones: Enough said
The newly released annual look at the digital world from online and mobile measurement firm comScore makes it quite clear that retailers better be ...
Data breaches hurt more than e-retailers' bottom lines
Money matters, but online merchants must keep consumers' trust and offer reassurances that their payment data is secure.
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Recent news reports suggest retail chains are testing technologies that allow them to track consumers' movements in stores by following the Wi-Fi signals from shoppers' smartphones.
Recent news reports suggest retail chains are testing technologies that allow them to track consumers' movements in stores by following the Wi–Fi signals from shoppers' smartphones. That extends into the bricks–and–mortar realm the kind of tracking marketers already do online with cookies and pixels. All this data can help marketers personalize offers, but it can also make shoppers uncomfortable. So how should retailers balance the value of customer data with privacy concerns?
Where do you think retailers should draw the line in tracking consumers' behavior? Join the discussion at Internet Retailer's Facebook page or on Twitter, using the hashtag #IRDiscuss.
"As long as you are honest and transparent about the data you are collecting and why—and you give customers the opportunity to opt out—there's no issue with it. This means marketers have to educate their customers about the risks and be honest and transparent in their practices. The audience will always dictate what is fair and what is not. The more honest and transparent you are, the more people will opt in."
– Jason Falls, vice president, digital strategy, e–retailer CafePress Inc.
"Retailers must understand the hypercritical role trust plays in relationships to brands and loyalty. If—without even meaning to—data tactics appear sneaky or snoopy, trust can be shattered and a customer lost forever. Retailers should proceed with an excess of caution and transparency when it comes to tracking and other data practices. They should disclose to the customer what's being collected and above all, what's in it for them."
– Rebecca Lieb, analyst, business research and advisory firm Altimeter Group
"Transparency is the key to these sorts of activities. Shoppers often will agree to provide their information in return for value. If retailers are transparent about their data uses and let consumers opt out of uses that make them uncomfortable, they can minimize concerns. And if value—such as coupons or a more personalized shopping experience—is provided in exchange for that data, shoppers generally tend to respond positively.ÊIt is the unexpected uses of data that create friction."
– Lisa Sotto, global privacy and data security practice head at law firm Hunton & Williams LLP
"If there's a robust way to opt out, companies should be able to do behavioral marketing, though sensitive areas—like health, sexuality and location—should probably only be collected and used with permission."
– Justin Brookman, director, consumer privacy, Center for Democracy & Technology
Training, signage and motivation are all critical elements to making in-store pickup work. If done ...
Posted 03/13/15
With holiday promotions starting as early as September, now is the time to assess the ...
Posted 03/12/15
If there's something you've bought offline that you weren't able to buy online, we're probably thinking about that."


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Helicoptershow 2012. And Mil Mi-2 Hoplite, imatr. 9428, LOM Prague
Familyday 2012
Picture taken while take off of this Helicopter from a field next to the Metro-station Sainte-Marguerite Dromel. This field is used by the Ambulance service and the Police.
Seems to be the firs... (more)
Photo taken during Lowestoft Sea Front Air Festival
About to land after a rescue mission. An Embraer is on short final while another traffic is turning base for 05 ..


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The Type 85S Stereo Direct Box from Countryman can be used to connect the output of any high impedance instrument, such as a keyboard or guitar, to a balanced XLR microphone input, allowing you to send signal to a mixer or mic preamp from your high impedance instrument. It features a 1/4" and RCA input per channel, as well as a gold-plated stereo 1/8" input. The unit also has two 1/4" throughputs, allowing you to run a high impedance signal to an amplifier. The two balanced XLR outputs allow you to run your signal to any standard mic level input.
Its two channels of FET based Class A amplifiers were designed to emulate the sound of a tube microphone preamplifier with smooth overloading, reducing distortion at high levels of input. This allows the Type 85S to avoid phase inversion, which can alter the fundamental frequency of the source.
The Type 85S features two channel independent ground lifts, which can reduce hum and electrical interference. The unit also has a 0dB, 15dB, or 30dB selectable pad per channel and is powered by external 48 volts or a nine-volt battery.
- Connectors and switches are recessed into a single-piece extruded case with extra thick walls. Internal electronics are molded in epoxy to protect against electrical damage
- The input can withstand 220 VAC and static spikes up to 20,000 volts
- Powered by external 48 volts to channel A or an internal 9 volt battery
- Up to 130 hours of use from a single nine-volt battery


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Caller said I owed back taxes and could settle out of court, when asked how he hung up. Scam
All Comments (2)
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Very rude. Threaten to put me in jail come to my job and have me arrested. Never happen stop calling me.
I got the same call and i knew right away it was a scam because 4 mo ago i got a call like this saying the same thing from a Allen Jones heave Indian accent the first one had me worried cus i did owe a back tax but i paid it they told me it was from 2008 and it was 3000$ I asked didn't you get my payment .they put me on hold and i could hear them talking in indian in the back ground i asked the to give me a couple hours to get there money they said i had to pay tonight or tomorrow i would be arrested at my work.After that i looked up the number and found a lot of notes on this. after i called this guy back and told them my attorney was the FBI they hung up.i called back saying i was a fbi agent getting complaints from this number they hung up.
called on cell phone, no message! Spam/scam caller !!! Find them and kill them !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Me too! I called it back & it said 233 (two hundred thirty three)! From Switzerland too! Ahhhh would I be charged? Thought it was legit as it's from the US!


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Our PT 710 Flowering Xeriscape Mix combines the low-growing green cover of PT 705 Xeriscape Mix with colorful wildflowers to provide an aesthetically pleasing ground cover for soil stabilization or low maintenance areas.
From unmowed highway banks to the casual meadow, to ecology lawns, this mix provides green cover year round without supplemental irrigation and with the added bonus of color- and the wildflowers also attract pollinators.
PT 710 is designed to be unmowed; the Lupine and Daisies will reach a height of approximately 24-36 inches.
Mix Includes:
Perennial Ryegrass
Hard Fescue
White Yarrow
Dutch White Clover
Perennial Lupine
O'Connor's Strawberry Clover
California Poppy
Sweet Alyssum
Shasta Daisy
Application Rate: 2 lbs per 1000 sq ft


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If I want hassles and warranty issues yeah...but no thanks. I am buying a Dell partly to get North American 24//7 Pro support for extended warranty of 5 years. It sort of defeats my purpose if I buy a different OS separately and need to have two hard drives bootable (with Windows 8 on one so I could switch to it if I had to call support). No thanks. The point here is to minimize hassles...not increase them. I just checked the Dell configurator and two of the problems are fixed (...last time I checked just a couple of days ago..the problems were still there). Dell is now offering Windows 7 Pro (had been offering Windows 7 Home only) and they have the 8GB sticks of Dual Channel DDR3 1600MHz RAM now so the configurator is now allowing one to purchase 12GB, 16GB, 24GB or 32GB RAM. No further information regarding a fix for the PCIe ports problem though.
The question is, is Server 8 out on MSDN yet...
I'm buying that Technet sub as soon as I get back home on Sunday.
2 recommendations
1 recommendation
quote:Microsoft releases Goodies


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Tag: Organic Agriculture - Page 10
Camel Milk Chocolate Bars are Sexy and Healthy and Strange
"Midnight at the oasis, send your camel to bed," was an oldie, and it's about to come back into its own as camel milk chocolate bars are soon to hit the scene. The benefits: they are organic, healthy and good for your sex life.
A Year of Green, Seasonal Eating in Oregon (Slideshow)
We talk a lot about eating local, seasonal food, but that can be tricky to visualize in different places around the world, depending on the season, region, even the micro-climate. To help showcase eating what's
Realities of a Low Emission Life in the French Pyrenees
Living off the land is often seen as the ideal for many aspiring greenies. Bucolic bliss. Healthy harvests. Cheery chickens. Milk making moo cows. Plentiful potatoes and a fresh figs. Sunsets sipping Sauvignon.
The Secret To A Delicious Soy Sauce? Organic Ingredients, Traditional Brewing
It is difficult to imagine Japanese food without soy sauce. The small containers with the black, fermented liquid are on every table. The best stuff is aged in cedar wood kegs and made in small
Meet The Faces of the Food Movement
In the lead-up to the conference Food and Society 2009: Gathering for Good Food the organizers have released an online slide show highlighting 75 portraits of people in the food movement who attended last year's event. Electronic communications have
Organic Compost Delivered To USDA Headquarters
The USDA ain't what it used to be. Ever since Earl Butz was charged with creating a highly efficient ag sector under Nixon and Ford the USDA has been about production of cheap calories through industrial agriculture. Enter the
Dear Obamas: Congrats on the Organic Garden
Dear Barack, Michelle, and Kids,
Obamas Turn White House Organic
Since Obama took office and the family moved into the White House things have changed in the food and agriculture landscape in the U.S. of A. Let's review.A collective, "Oh No!"
It's Time To Get GMO Soy Lecithin Out Of Certified Organic Food
Time sensitive call to action. Deadline is Monday, November 3.
Arran Stephens of Nature's Path on Independence in the Fast-Consolidating Food Industry
Arran Stephens is the CEO and co-founder, with his wife Ratana, of Nature's Path. The company is one of the leading privately owned and family operated organic food companies in North America. They sell their certified organic cereals, breads, cookies,
Hess Natur Organic Fashion Coming to America
It sounds like a common enough story. Freshly minted parent can't find chemical-free clothing for their new-to-the-world child. What makes this version different from so many of the introductions found on new green apparel websites, is that it
Esprit Ecollection Clothing: Ahead of Their Time?
The other day in profiling the company Terrapax, we suggested that Nau was not, strictly speaking, 'ahead of its time', but rather they were treading a path laid down by eco-pioneers, well over a decade ago. Today we take a peek at Esprit's
Terrapax Bags: Ahead of Their Time?
With the demise of Nau, many commentators have been suggesting the trouble was that the company was ahead of its time. We respectfully disagree. Firstly, if ever there was a time for businesses to flourish, who are environmentally and socially
Patagonia Add Five Products to Footprint Chronicles
Patagonia have updated their Webby Award nominated Footprint Chronicles website with five new product lifecycle assessments (LCAs). The additions are their Nine Trails shorts, Sugar and Spice shoe, Capilene 3 bottoms Vitaliti strappy dress and
Kylie Kwong Cooks Carbon Clean
Kylie Kwong is a well known Australian celebrity chef. What is probably less well known is her passion for the environment. A commitment well demonstrated via her Sydney chinese restaurant, Billy Kwong.
Seven Wonders for a Cool Planet [Go the Bicycle!]
Now it seems like later
World's Biggest Green Drinks - Melbourne, Australia
Melbourne is arguable the sporting capital of Australia. Plant competitive species of grass in two halves of a stadium, and in a day the the city would've sold out of tickets to watch which would grow the fastest. So it should come as no surprise that
My Organics Are Bigger than Yours
Many biodynamic moons ago we reported that Australia had the world's largest area of organically farmed land. That remains the case three years on. But so does the caveat that it is mostly due to that


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Home :: Search for a Diamond :: EGL Certified Diamonds :: Round Brilliant :: 1.64 cts. Round Diamond
EGL :: Ask a Question
Product Selection
Gold Wedding Band TT-1154
Hello I am just sending an email THANKING YOU for my order I just received it today and am VERY EXCITED I will be using you for future orders. I am...
Love the Rings
We absolutely love our rings! They are beautiful. The craftsmanship is amazing! We had looked several places and finally pick Joshua's. They had the best...
Three Piece Wedding Set JRX-1261
Thanks for all you help in getting me and my wedding set they are very beautiful and my wife to be just loves them. I loved how you took my order and got...
Recently Viewed
Copyright © 2015 Joshua's Jewelry. Powered by WSC Cart


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I'll Show You Mine if You Show Me Yours Sat Oct 13
My grandmother....born 1892, she once dated/was engaged to the son of a jeweler. Some of her pieces, a 24k solid, but hollow bead choker, 18k rings, gold plated pearl & ruby buttons on a chain.....the 18k orchid brooch was purchased by me later.....
Here is the story to go with my fire picture:
Arson is suspected in house fire
Arson investigators are looking into a fire that burned a vacant house Saturday and singed two others in northwest Oklahoma City.
Early reports were that someone set the fire at 2309 W Lindley just before noon, said Bobby Lax, a battalion chief with the Oklahoma City Fire Department.
Two vagrants who were inside the single-story house escaped uninjured, but the house was a total loss, Lax said.
The vacant house sustained about $20,000 in damage, while the adjacent houses each sustained several thousand dollars in heat damage, Lax said.


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Three trapped firefighters had to deploy their personal fire shelters as a rapid wind shift sent a Northern California wildfire burning over their location Monday, authorities said. All three survived with no serious injuries.
Three trapped firefighters had to deploy their personal fire shelters as a rapid wind shift sent a Northern California wildfire burning over their location Monday, authorities said. All three survived with no serious injuries.
The firefighters had created a predetermined safety zone earlier in the day and retreated there when the fire worsened about 5:30 p.m. Monday, Beaver Fire spokesman Corey Wilford said. Still, the flames burned over their location. A thunderstorm produced winds as high as 35 mph, causing extreme fire behavior.
Wilford said all firefighters in the area were withdrawing as the thunderstorm approached. All personnel were safe late Monday night, he said.
The three were not immediately identified. Wilford said he didn't know if they suffered any minor injuries.
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Most Read Stories
The fire in Siskiyou County near Klamath River, California, has burned across nearly 40 square miles and was reported 30 percent contained.
The sheriff's office issued more mandatory evacuation notices Monday but Wilford did not immediately know how many homes were affected.
The Beaver Fire and a second Northern California blaze reportedly were threatening nearly 750 rural homes.
Meanwhile, crews were anticipating the possibility of more lightning strikes while battling a lightning-sparked wildfire in Mendocino County about 200 miles southwest of the Klamath blazes. The fire near Laytonville had burned through nearly 15 square miles and was threatening nearly 60 structures. Mandatory evacuation orders remained in place.
Elsewhere in the West, rescuers escorted to safety 19 hikers trapped on Sunday by a wildfire atop Saddle Mountain State Park near Seaside, Oregon.
And in Idaho, firefighters made progress against the state's largest wildfire, which had burned 101 square miles on the Idaho side of the Snake River near the Oregon and Washington border. The fire was nearly 50 percent contained, though crews were expecting triple-digit temperatures and gusty winds later in the week that could pose problems.
Follow the writers on Twitter at @SudhinT and @APtcollins.


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New Kensington Hotel Deals
Hotel Deals > Pennsylvania > New Kensington
Clarion Hotel
300 Tarentum Bridge Road
New Kensington, Pennsylvania
New Kensington, Pennsylvania
Advance Purchase
|Valid Dates:
|April 17, 2012 until December 31, 2199
|99 night maximum length of stay. 7 day advance booking required.
Anyone booking within the designated timeframe in advance qualifies for this rate. This is a prepaid rate that cannot be changed or cancelled. Standard hotel amenities are included. Valid ID is required at check-in.


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1.5 Evolution stack - pond play
Posted 07 December 2009 - 09:05 PM
Here's a video (with music) of what I call a Rev 1.5 Evolution stack. It's a 3-stack of a 1.5 UL (pre-SLE), an SLE, and a B-series.
The stack lines, 100# blended spectra (old dual-line set), are all 5.5 ft attached to 2" loops larks-headed through all the endcaps bungi holes.
This was my first attempt at stacking Revs. I did a bit of test flying over the field to make sure that it stayed together first before going over the water.
Rev on - David
Posted 07 December 2009 - 09:23 PM
Denny #12
Posted 07 December 2009 - 09:39 PM
Posted 07 December 2009 - 09:56 PM
Nice flying!!!!
"When the power of love becomes more important than the love of power,
then there will be peace"
Posted 08 December 2009 - 01:33 AM
I tried to play in a pond with one of my Sedgwicks. Got the lines caught on some long grasses and crashed and burned. Or more correctly crashed and drowned.
Ended up dragging the soggy muddy mess out by the lines, trying not to break anything.
Was fun while it lasted though.
Posted 08 December 2009 - 02:19 AM
"Cya in the Sand!....."
"Slack lines are fine lines!"
"You don't need a weatherman to know which way the wind blows" BD
"One good thing about music, when it hits you feel no pain" BM
Posted 08 December 2009 - 03:17 AM
Posted 09 December 2009 - 12:14 PM
John Barresi
johnbarresi.com | kitelife.com | learnkites.com | kitemap.org | Rev Tutorials
youtube.com/kitelife | facebook.com/kitelifemagazine | KiteLife on Google+
"We cannot direct the wind, but we can adjust the sails."
(found in a fortune cookie - possibly an Einstein quote)
My full list of kite articles - kitelife.com/author/john-barresi
Please reward posts that are helpful, give positive reputation by clicking on "Like This" button on the right side of each post.
Posted 09 December 2009 - 08:22 PM
Helena, MT
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Student Leadership and Service (SLS)
Alternative Breaks
This program partners Lewis & Clark students with communities around the world to create service opportunities that are both productive and educational. The intention behind Alternative Breaks is based upon the pursuit of positive social change and social justice. These programs are initiated and led by students.
New Student Trips
Prior to Fall semester, SLS partners with New Student Orientation and College Outdoors to plan Beyond Portlandia trips. Within these trips, student leaders facilitate meaningful service and learning experiences around issues of environmental action and economic justice. Visit the College Outdoors website for more information.
Fall Trips
Alternative Fall Break trips explore social injustices and positive social change strategies in communities close to Portland. The Fall 2014 trip will visit the Yakama Nation. Applications are available early fall term on our website. Contact us for more information!
Spring Trips
Our unique Alternative Spring Break program utilizes a critical service-learning model built on a foundation of mutually-beneficial community-campus partnerships. ASB participants interrogate social injustice and pursue positive social change. Trip leaders are chosen in fall term. Check back for applications and let us know if you have questions.


text: Beazley PLC Company Profile (LON:BEZ) Tweet Analyst RatingsEarningsDividendsInsider TradesCompany ProfileToday's Chart Consensus Ratings for Beazley PLC (LON:BEZ) (?) The ratings breakdown includes the most recent rating from each analyst that has rated the stock within the last twelve months. The ratings score is a calculation of the average number of sell, hold, buy and strong buy ratings (0-1.5 = Sell, 1.5-2.5 = Hold, 2.5-3.5 = Buy, >3.5 = Strong Buy). The consensus price target is a mean average of the most recent price target set by each analyst that has set a price target for the stock in the last twelve months.Ratings Breakdown: 1 Sell Rating(s), 4 Hold Rating(s), 5 Buy Rating(s)Consensus Rating:Hold (Score: 2.40)Consensus Price Target: GBX 287.33 Analysts' Ratings History for Beazley PLC (LON:BEZ) Show: All Ratings For This Stock Only the Most Recent Rating From Each Brokerage DateFirmActionRatingPrice TargetDetailsShare3/26/2015Westhouse SecuritiesReiterated RatingSellGBX 260View 3/24/2015Numis Securities LtdReiterated RatingHoldGBX 305View 3/17/2015Westhouse SecuritiesReiterated RatingSellView 3/16/2015Sanford C. BernsteinReiterated RatingOutperformGBX 315View 3/16/2015Deutsche BankInitiated CoverageBuyGBX 306View 3/5/2015Westhouse SecuritiesReiterated RatingSellView 2/27/2015JPMorgan Chase & Co.Lower Price TargetNeutralGBX 275 -> GBX 255View 2/19/2015Westhouse SecuritiesReiterated RatingSellView 2/17/2015Shore CapitalReiterated RatingBuyView 2/10/2015Canaccord GenuityReiterated RatingHoldGBX 280View 2/9/2015Westhouse SecuritiesDowngradeSellGBX 260View 2/5/2015JPMorgan Chase & Co.Reiterated RatingNeutralGBX 275View 2/5/2015Shore CapitalReiterated RatingBuyView 2/5/2015Numis Securities LtdDowngradeHoldGBX 305View 2/5/2015Westhouse SecuritiesReiterated RatingNeutralView 2/4/2015Sanford C. BernsteinReiterated RatingOutperformGBX 325View 2/2/2015NomuraReiterated RatingBuyView 1/26/2015Sanford C. BernsteinReiterated RatingOutperformGBX 305View 1/22/2015JPMorgan Chase & Co.Reiterated RatingNeutralGBX 275View 1/22/2015Canaccord GenuityBoost Price TargetHoldGBX 270 -> GBX 280View 1/22/2015Westhouse SecuritiesReiterated RatingNeutralGBX 260View 1/13/2015Numis Securities LtdReiterated RatingAddGBX 305View 1/8/2015Westhouse SecuritiesReiterated RatingNeutralView 1/6/2015Sanford C. BernsteinReiterated RatingOutperformGBX 305View 12/18/2014Canaccord GenuityReiterated RatingHoldGBX 270View 12/18/2014Westhouse SecuritiesReiterated RatingNeutralView 12/12/2014Sanford C. BernsteinReiterated RatingOutperformGBX 305View 12/10/2014Westhouse SecuritiesDowngradeNeutralGBX 275 -> GBX 260View 12/10/2014JPMorgan Chase & Co.Boost Price TargetNeutralGBX 258 -> GBX 280View 12/1/2014Sanford C. BernsteinReiterated RatingOutperformGBX 305View 11/28/2014Canaccord GenuityReiterated RatingHoldGBX 270View 11/27/2014Westhouse SecuritiesReiterated RatingAddView 11/17/2014Sanford C. BernsteinReiterated RatingOutperformGBX 305View 11/17/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 258View 11/13/2014Westhouse SecuritiesReiterated RatingAddView 11/6/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 258View 11/5/2014Numis Securities LtdDowngradeAddGBX 305View 10/30/2014Westhouse SecuritiesReiterated RatingAddGBX 275View 10/22/2014Westhouse SecuritiesReiterated RatingAddGBX 275View 10/20/2014Sanford C. BernsteinReiterated RatingOutperformGBX 305View 10/13/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 258View 10/9/2014Westhouse SecuritiesReiterated RatingAddView 10/2/2014Sanford C. BernsteinReiterated RatingOutperformGBX 305View 9/30/2014Canaccord GenuityDowngradeHoldGBX 270View 9/25/2014Westhouse SecuritiesReiterated RatingAddView 9/23/2014Sanford C. BernsteinReiterated RatingOutperformGBX 305View 9/16/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 258View 9/15/2014Sanford C. BernsteinReiterated RatingOutperformGBX 305View 9/11/2014Westhouse SecuritiesReiterated RatingAddView 9/1/2014Berenberg BankReiterated RatingBuyGBX 290View 8/22/2014Westhouse SecuritiesReiterated RatingAddView 8/14/2014Westhouse SecuritiesReiterated RatingAddView 8/1/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 258View 7/31/2014Westhouse SecuritiesReiterated RatingAddGBX 275View 7/23/2014Canaccord GenuityLower Price TargetBuyGBX 290 -> GBX 270View 7/22/2014Berenberg BankReiterated RatingBuyGBX 278View 7/22/2014Espirito Santo Investment Bank ResearchReiterated RatingNeutralGBX 283View 7/22/2014Numis Securities LtdReiterated RatingBuyGBX 305View 7/18/2014Westhouse SecuritiesReiterated RatingAddGBX 275View 7/18/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 258View 7/10/2014Westhouse SecuritiesReiterated RatingAddGBX 275View 7/3/2014NomuraReiterated RatingBuyGBX 292View 6/27/2014Westhouse SecuritiesReiterated RatingAddView 6/23/2014Berenberg BankUpgradeBuyGBX 271 -> GBX 278View 6/16/2014Westhouse SecuritiesReiterated RatingAddView 6/5/2014Westhouse SecuritiesReiterated RatingAddView 6/3/2014Berenberg BankUpgradeBuyGBX 271 -> GBX 278View 5/22/2014Westhouse SecuritiesReiterated RatingAddGBX 275View 5/8/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 258View 5/1/2014Numis Securities LtdReiterated RatingHoldGBX 305View 4/30/2014Westhouse SecuritiesReiterated RatingAddGBX 275View 4/22/2014Westhouse SecuritiesUpgradeAddGBX 275View 4/10/2014Westhouse SecuritiesReiterated RatingNeutralView 4/2/2014JPMorgan Chase & Co.Boost Price TargetNeutralGBX 238 -> GBX 258View 4/1/2014Numis Securities LtdReiterated RatingBuyGBX 305View 3/27/2014Westhouse SecuritiesReiterated RatingNeutralView 3/13/2014Westhouse SecuritiesReiterated RatingNeutralView 3/3/2014Numis Securities LtdReiterated RatingBuyGBX 305View 2/27/2014Westhouse SecuritiesReiterated RatingNeutralView 2/12/2014Westhouse SecuritiesDowngradeNeutralGBX 265 -> GBX 275View 2/11/2014Canaccord GenuityReiterated RatingBuyGBX 290View 2/6/2014Espirito Santo Investment Bank ResearchReiterated RatingNeutralView 2/6/2014Numis Securities LtdUpgradeBuyGBX 300 -> GBX 305View 2/6/2014JPMorgan Chase & Co.Reiterated RatingNeutralGBX 238View 2/5/2014NomuraBoost Price TargetBuyGBX 225 -> GBX 292View 2/3/2014Numis Securities LtdReiterated RatingAddGBX 300View 1/31/2014Canaccord GenuityLower Price TargetBuyGBX 270 -> GBX 265View 1/30/2014Westhouse SecuritiesReiterated RatingAddGBX 265View 1/16/2014Numis Securities LtdDowngradeAddView 1/16/2014Espirito Santo Investment Bank ResearchDowngradeNeutralGBX 182 -> GBX 260View 1/16/2014Westhouse SecuritiesReiterated RatingAddView 1/15/2014JPMorgan Chase & Co.Boost Price TargetNeutralGBX 236 -> GBX 238View 1/7/2014Westhouse SecuritiesReiterated RatingAddView 1/6/2014Numis Securities LtdReiterated RatingBuyGBX 280View 12/19/2013Westhouse SecuritiesReiterated RatingAddView 12/17/2013JPMorgan Chase & Co.Reiterated RatingNeutralGBX 236View 12/5/2013Westhouse SecuritiesReiterated RatingAddView 12/2/2013Numis Securities LtdReiterated RatingBuyGBX 280View 11/28/2013Canaccord GenuityBoost Price TargetBuyGBX 260 -> GBX 270View 11/21/2013Westhouse SecuritiesReiterated RatingAddView 11/15/2013Berenberg BankBoost Price TargetHoldGBX 227 -> GBX 258View 11/7/2013Westhouse SecuritiesReiterated RatingAddGBX 245View 11/1/2013Numis Securities LtdReiterated RatingAddGBX 260View 10/30/2013Westhouse SecuritiesUpgradeAddGBX 245View 10/24/2013Westhouse SecuritiesReiterated RatingNeutralView 10/16/2013Westhouse SecuritiesReiterated RatingNeutralGBX 245View 10/8/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralView 9/27/2013Canaccord GenuityReiterated RatingBuy -> BuyGBX 260View 9/27/2013Berenberg BankBoost Price TargetHold -> HoldGBX 238 -> GBX 278View 9/26/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralView 9/12/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralView 9/11/2013JPMorgan Chase & Co.Reiterated RatingNeutral -> NeutralGBX 223View 9/2/2013Numis Securities LtdReiterated RatingAdd -> AddGBX 260View 8/23/2013Westhouse SecuritiesReiterated RatingNeutralView 8/15/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralView 8/7/2013Canaccord GenuityReiterated RatingBuy -> BuyGBX 260View 8/1/2013Numis Securities LtdReiterated RatingAdd -> AddGBX 260View 8/1/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralView 7/25/2013JPMorgan Chase & Co.Reiterated RatingNeutralGBX 223View 7/24/2013Canaccord GenuityBoost Price TargetBuy -> BuyGBX 245 -> GBX 260View 7/23/2013Shore CapitalReiterated RatingBuy -> BuyView 7/23/2013Berenberg BankReiterated RatingHoldGBX 238View 7/23/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralGBX 245View 7/22/2013Numis Securities LtdReiterated RatingAdd -> AddGBX 260View 7/18/2013JPMorgan Chase & Co.Reiterated RatingNeutral -> NeutralGBX 223View 7/15/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralGBX 245View 7/4/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralView 7/3/2013JPMorgan Chase & Co.Reiterated RatingNeutral -> NeutralGBX 233 -> GBX 233View 6/20/2013Berenberg BankDowngradeBuy -> HoldGBX 232 -> GBX 238View 6/13/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralView 5/30/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralGBX 245 -> GBX 245View 5/30/2013JPMorgan Chase & Co.Reiterated RatingNeutral -> NeutralGBX 233 -> GBX 233View 5/28/2013JPMorgan Chase & Co.Reiterated RatingNeutralGBX 233View 5/22/2013Westhouse SecuritiesDowngradeAdd -> NeutralGBX 235 -> GBX 245View 5/16/2013Westhouse SecuritiesReiterated RatingNeutral -> NeutralGBX 245 -> GBX 245View 5/13/2013Canaccord GenuityReiterated RatingBuy -> BuyGBX 245View 5/9/2013Espirito Santo Investment Bank ResearchReiterated RatingBuy -> BuyGBX 182 -> GBX 182View 5/9/2013Numis Securities LtdReiterated RatingHold -> HoldGBX 215 -> GBX 215View 5/2/2013Westhouse SecuritiesReiterated RatingAdd -> AddView 4/24/2013JPMorgan Chase & Co.Reiterated RatingNeutral -> NeutralGBX 177 -> GBX 177View 4/19/2013Canaccord GenuityReiterated RatingBuy -> BuyGBX 225 -> GBX 225View 4/11/2013Westhouse SecuritiesReiterated RatingAddGBX 234.96 -> GBX 234.96View 4/5/2013NomuraReiterated RatingBuyGBX 222.81 -> GBX 222.81View 4/4/2013Numis Securities LtdDowngradeHoldGBX 212.91View (Data available from 4/1/2013 forward) Earnings History for Beazley PLC (LON:BEZ)No earnings announcements for this company have been tracked by Analyst Ratings Network Dividend History for Beazley PLC (LON:BEZ)AnnouncedPeriodAmountYieldEx-Dividend DateRecord DatePayable DateShare2/5/2015GBX 186.12%2/26/20152/26/20153/27/2015 7/22/2014GBX 3.101.19%7/30/20147/30/20148/29/2014 2/6/2014GBX 227.94%2/26/20142/26/20143/28/2014 (Data available from 1/1/2013 forward) Insider Trading History for Beazley PLC (LON:BEZ)Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionSEC LinkShare3/30/2015Clive WashbournInsiderSell164,714GBX 289.69£477,159.99 2/18/2015Clive WashbournInsiderSell209,888GBX 296.12£621,520.35 2/16/2015Clive WashbournInsiderSell6,384GBX 293.50£18,737.04 2/13/2015Martin BrideInsiderSell14,200GBX 293.25£41,641.50 (Data available from 1/1/2013 forward) About Beazley PLC Beazley plc is a holding company engaged in global specialist risk insurance and reinsurance business. Its segment includes life, accident and death, underwrites life, health, personal accident, sports and income protection risks; marine , underwrites a broad spectrum of marine classes including hull, energy, cargo and specie, piracy, aviation, kidnap and ransom and war risks; political risk and contingency, underwrites terrorism, political violence, expropriation and credit risks; property, underwrites commercial, high-value homeowners and construction and engineering property insurance; reinsurance, specializes in writing property catastrophe, property per risk, casualty clash, aggregate excess of loss and pro-rata business, and specialty lines , underwrites professional liability, management liability and environmental liability, including architects and engineers, healthcare, lawyers, technology, media and business services, directors and officers and employment practices risks. Headlines: (3/31) Research Analysts' Recent Ratings Updates for Beazley PLC (BEZ) (3/31) Insider Selling: Beazley PLC insider Sells 164,714 Shares of Stock (BEZ) (3/24) Numis Securities Ltd Reiterates Hold Rating for Beazley PLC (BEZ) (3/31) Total Voting Rights (3/17) Beazley PLC Stock Rating Reaffirmed by Westhouse Securities (BEZ) (2/2) Beazley PLC Stock Rating Reaffirmed by Nomura (BEZ) (12/11) Beazley PLC Rating Lowered to Neutral at Westhouse Securities (BEZ) (2/24) Beazley : REG - Beazley PLC -Director Shareholding (2/22) REG - Beazley PLC -Annual Report & Accounts & Notice of AGM (10/16) Beazley PLC BEZ Director/PDMR Shareholding Industry, Sector and Symbol: Sector: N/A Industry: N/A Sub-Industry: N/A Exchange: LON Symbol: BEZ CUSIP: Key Metrics: Previous Close: $4.3150 Day Moving Average: $292.88200 Day Moving Average: $277.79P/E Ratio: 692.58P/E Growth: -1.43Market Cap: $1.46BCurrent Quarter EPS Consensus Estimate: $25.80 EPS Additional Links: View BEZ on Google FinanceView BEZ on Yahoo FinanceView BEZ's Company Profile on ReutersSearch for Beazley PLC on Google Beazley PLC (LON:BEZ) Chart for Wednesday, April, 1, 2015 (Chart Provided by Yahoo Finance)


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You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"Text has enough flourish while still being easily readable - and the writing was not too small, which was a problem with other invites we had considered! Nice thick paper, back design did not show through to the front. Tree image was very clear, not blurry or smudged. Love this design!"
"Everything about this invitation was beautiful! The colors (I choose the blue and green) were perfect and had a watercolored appearance. The quality of the paper was much better than I expected as was the lettering and customer service."
"The paper is fantastic- very nice and thick, not cheap feeling at all. The leaves look hand painted. The whole design is really really nice- it's even more beautiful in person. I was more than impressed. I received my invitations faster than expected - printing and shipping was FAST. Much faster than the time Wedding Paper Divas had estimated- which I appreciated. Overall, I would HIGHLY recommend this invitation along with this wonderful, helpful company."
"These invites are perfect. Simple and beautiful and really well made. The print is nice looking and the paper is very sturdy! So happy with them! Perfect with the Togetherness In Love RSVPs!"
"We absolutely loved sending these invitations. The classic design fit our wedding's theme perfectly and the thermography was the perfect touch to make them feel more luxe than standard printing. Everything arrived perfectly packaged and in great condition--could not have been an easier process. WPD was a delight to work with and quickly made changes and provided proofs. I would recommend these invitations - and this site - to anyone shopping for invitations."


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For the next week the Morpeth-based internet grocery ordering service which specialises in championing local producers, is offering a 10% discount on all Davenport's Chocolates Easter eggs.
Made by North Shields-based Jane Williams (pictured), the luxury eggs are filled with a selection of unusual chocolates, including raspberry and rose, cinnamon toffee, franzipan, fudge brique and jan-doo-yah.
Prices start at pounds 10.80. Go to www.foodlocalfood.com WEARSIDE bars, pubs and clubs are one step closer to being honoured under a national awards scheme.
The city's first Best Bar None awards, part of a UK-wide initiative, are due to be held on March 15 at the Best Western Roker Hotel and will highlight licensed premises which have exhibited responsible management and a safe and welcoming environment.
The awards, which are backed by the Home Office, were launched in 2003 and have been adopted nationwide, including in Durham and Newcastle.
GO tropical this spring with recipes that bring the taste of Brazil to the UK.
The free online recipe guide and video demonstrations show how to make dishes such as Brazilian bean risotto (pictured above) and vegetarian moqueca and sonhos, an Amazonian speciality. The recipes, which can be made with ingredients readily available in the UK, highlight the different styles of Brazil's regions and are available to download at www.braziltour.com MORE and more people are discovering the delights of growing their own vegetables, whether in their back garden or in an allotment.
The Home-Grown Vegetable Manual (Haynes, pounds 17.99) offers clear and practical advice on everything from finding an allotment and getting to know your soil, to pest control, harvesting, storing and preserving.
Other topics covered include essential tools and techniques, using fertilisers, successful composting and growing veg in a flower garden.
Reader Opinion
|Printer friendly Cite/link Email Feedback
|Title Annotation:
|The Journal (Newcastle, England)
|Mar 6, 2009
|Previous Article:
|A friendly word of warning for veggies; FOOD.
|Next Article:
|Pint of bitter and a poem, please; BEER.


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Thomas December 15, 2012
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saggytits4me January 7, 2014
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Tinder is one of the first apps to include Android Wear support. To set up, just login to Tinder on your phone. Send messages and view profiles from notifications, and say "Start Tinder" to start swiping on relevant people near you, all on your watch.
What's New
Hot or Not
Here's what you do:
• Sign in via Facebook
• Add your best photos
• Play the Game
Hot or Not will show you how popular you and your friends are, as well as a list of the Hottest people nearby, wherever you may be; at a music festival, on college campus, or hanging out in the city.
When you open our app, we ask for your mobile number and permission to read/send text messages. We only need this to find the confirmation code that we send via text message. This is to help us confirm you're a real person, and keep our app spam-free. We will never send an SMS without your permission.
* 100% Surprising *
* 100% Safe and confidential *
* 100% Trendy *
HAPPN, how does it work?
1. Every time you cross paths with someone in real life, their profile shows up on your timeline!
2. You can check out the profiles on the timeline whenever you want. You'll be able to see the number of times you've crossed paths with someone, as well as the time and place of your last encounter.
3. There's someone you like? Like them secretly: they won't find out… unless the interest is mutual! But you can also choose to be noticed by sending a Charm.
4. And when you've both liked each other, you have a Crush, which allows you to start a conversation.
√ HAPPN was designed on the basis of mutual opt-in: you'll never receive any messages from people you haven't liked.
√ Here at HAPPN, your privacy is a priority: be assured that on happn, your localisation is always invisible to other members!
√ Downloading HAPPN and using the service is completely free! The "Charm" feature is optional. It is free for women while men need to pay to use this option. Men get several Charms for free when they first sign up.
"It's just like in real life. Before they can start a conversation on the app, both users must have crossed paths before. Success seems to be just round the corner…" Elle, February 2014
"I found the guy I had seen in the bus. We had looked at each other… and happn helped us see each other again." Jane, 26, Paris
"It's just crazy—I'm now dating a neighbor who lives across the street. We had bumped into each other a few times but had never talked before…" Katie, 28, Paris
• No phone numbers, just usernames.
• Filters that let you decide who to talk to.
• Memes, funny pics, celebrity news, videos, gifs... share what you like.
• Start a public group chat for up to 50 people with just a #hashtag. Or create a private group.
More than 200 million people use Kik to connect with friends, no matter where they meet them – at school, in a social app, or in an online game. Just ask: "What's your Kik?"
• ALWAYS FREE: No annual subscription fee. Absolutely free for life.
• FREE VOICE & VIDEO CALLS: High-quality free calls to anywhere in the world.
• GROUP CHAT: Create group chats with up to 100 people.
• MULTIMEDIA MESSAGING: Send video, image, text, and voice messages.
• STICKER GALLERY: Hundreds of free, fun, animated stickers to express your feelings from some of your favorite cartoons and movies.
• MOMENTS: Share your best moments on your personal photo stream.
• BETTER PRIVACY: WeChat gives you the highest level of control over your privacy. It's the only messaging app to be certified by TRUSTe.
• MEET NEW FRIENDS: Use "Friend Radar", "People Nearby" and "Shake" to meet others.
• ADDICTIVE GAMES: Compete with your friends on some of the hottest games.
• REALTIME LOCATION: Instead of having to tell others where you are, just use real-time location sharing.
• LANGUAGE SUPPORT: Localized in 20 different languages and can translate messages to any language.
• AND MORE: Desktop app, custom wallpaper, custom notifications, group walkie-talkie, official accounts.
VOO Chat - Fun Photo Game App
[How it works]
• Jump in via Facebook, LOVOO, e-mail or Google
• Share your best selfies with the world
• Swipe through cool people
• Make new connections wherever you are
• Your VOO-Score shows you how popular you are. For every "Like" your score goes up!
• VOO's verification process guarantees that the person behind the profile is real.
• Our support team is there to answer your questions. Tweet us @vooapp
Sex Offenders Search
*** Covers all 50 US states plus Puerto Rico ***
✓ Provides a photo, detailed offender records, birth date, physical profile, etc. for each offender.
✓ The database is updated daily!
✓ Search offenders by:
- Your current location
- Any point on the map
- Any address, city or zip
- Offender name
✓ The only application on the market that allows to search offenders by name!
✓ No registration needed- download and go.
✓ There are no monthly or other hidden fees.
✓ Interactive map updates as you drag from location to location.
✓ Provides the most accurate data.
✓ The list view contains the offenders pictures as well. You can quickly scroll through them and pick the one you want to see more details for.
✓ Tablet optimized for all screen sizes
✓ Supports "Move to SD card".
Our world can be a dangerous place. Knowledge and awareness are our first line of defense.
Are you moving to a new area? Are you buying/renting a new house? Will you be living close to any of those dangerous individuals? Are your children visiting a relative or a friend? Will they be safe?
Just activate your phone's GPS and locate registered sex offenders in the area around you. You can also search by city, zip code or an actual address.
Offenders will be displayed on an interactive map on your device. You will be able to navigate around and click on any of the locations to see the picture, name, address, and offenses of any individual you select.
Currently SOS only contains registered sex offenders located in the United States. Our database is updated once a day with new information as it becomes available.
*Featured on the Today Show, NBC October 29th.
*Featured on the Daily BUZZ TV Show, March 18th: "This is the app you need to know about to protect your children"
Other TV reviews for SOS:
ABC - WFTV Orlando Sep 24, 2009
NBC - WVLA Baton Rouge Oct 2, 2009
FOX - KTVI St. Louis Feb 2, 2010
FOX - WITI Milwaukee Mar 3, 2010
ABC - KITV Honolulu Mar 2, 2010
ABC - WGGB Springfield Mar 4, 2010
Paktor: Make New Friends
- New Group Chat feature: Chat with multiple new people with similar interests all in a room!
- Additional Filters: Choose exactly who you want see and match with, with our new additional filters for job, education, height and more!
- Auto-Translation: Match across borders, meet new people, we take care of any language barriers
- And much more… download/update now!
Paktor is the #1 free social app that is changing the socializing and dating world. With millions of users on Paktor, you can easily match and chat with new friends. No awkward introductions, just find people near you, filter by preferences, swipe, match, chat, meet and date!
Paktor is a socializing app that acts as your instant introduction to people you are interested in. As you scroll through photos of people who are in your area, you can "like" them or "pass" them. If you like a person and they like you back, it will be a match and Paktor sets you two up to talk and chat through the social messenger features.
There are people you'd like to meet and people who would like to meet you. Paktor makes sure the two match up. With Paktor as your matchmaker, socializing, dating, or just hanging out becomes that much easier.
Paktor features:
- Change the way you look at dating, socializing and meeting new people
- Get paired up with people who like you and are in your area
- Only people who like you will be able to see if you liked them, keeping everything anonymous
- If you made a mistake, no worries! Change your accidental dislikes to likes
- Send match requests to people you really want to meet
- Set your search preferences by age, location, distance, gender, countries and more to help you find that perfect match to talk to
- Personalize your profile with photos, taglines and descriptions of yourself
- Use photos from your camera, camera roll and Facebook in your profile
Paktor media mentions:
- featured on BBC
- featured on CNBC
- featured on Yahoo
- featured on Techinasia
- featured on Sina
and more...
"I can definitely see why the app is popular... it's addictive" - Techinasia
Need help? Please email us at email@example.com
LINE: Free Calls & Messages
▷ LINE's New Features
Chat search feature: Never lose track of a conversation again with the new chat search feature. Search chat room names and messages with Android 4.1 and above or just chat room names with Android 2.3 and above.
▷ LINE's Main Features
Free voice and video calls: Use your PC or smartphone to keep in touch with friends and family both at home and abroad, or hold a business meeting on the go!
Instant messaging anywhere: Conversation is just a tap away. Spice it up with LINE's exciting collection of stickers or send pictures, videos, and even GPS coordinates to let your friends know what you're up to.
A full-featured social networking service: Post your day-to-day activities to your Timeline or comment on your friends' posts.
Group chats: Share important information with your co-workers or talk about mutual interests with your closest friends.
Find new expressions in the Sticker Shop: The world's largest collection of stickers features famous and unique characters from around the world to let you express yourself just the way you want to.
Stay informed with LINE official accounts: Connect directly with your favorite celebrities and companies by friending their official accounts.
Get connected to new apps: LINE provides a gateway to entertainment and lifestyle apps that will keep you entertained and bring new convenience to your life.
We recommend that you use LINE with Android OS versions 2.3 and above.
For more information about LINE, check out our official website.
Skype - free IM & video calls
• Find all your friends and family in an instant - With over 250 million people using Skype, you're bound to bump into someone you know.
• Talk with your fingers - No matter where you are, your friends are always at your fingertips with free instant messaging.
• Call your world from Skype - Talk to your heart's content with free voice and video calls to all your friends and family on Skype.
• Low cost calls to mobiles and landlines too - Keep in touch, even if they're not on Skype, with low cost calls and SMS to mobiles and landlines on the other side of town or the world.
• Share your favourite snaps - Got a favourite photo to share? Send it over Skype to friends and family and you won't have to worry about email size limits or expensive MMS charges.
• Chat with anyone, anywhere - Skype's available on smartphones, tablets, PCs, Macs, and even TVs. Whatever device your friends or family use, Skype just works. Simple.
• Video messaging – Record life's everyday moments and share them with the people who matter most, with free and unlimited video messaging over Skype.
* Operator data charges may apply. We recommend using an unlimited data plan or WiFi connection.
Follow PicBeauty on twitter @PicBeautify
or Like PicBeauty on facebook to communicate with us!.
*****PicBeauty, make life more beautiful!*****
You wanna be more pretty ?
R you worried about your facial wrinkles, pimples?
Do you want to customize natural and elegant photo for Facebook,Twitter,LinkedIn,Snapchat,Pinterest,Instagram or other social sites?
PicBeauty brings your wishes to reality!!!
PicBeauty is a facial photo editing app, which is a brother App of PicFrame+ and PicFun. It can help you weaken pimples and wrinkles by using "Smooth" option, whiten face skin and teeth obviously by using "Whiten" option.
This system removes the unwanted components that spoil the beauty of face , makes your skin smoother , emphasizes the shadow, and makes entire face looks more beautiful.
Easy beauty, easy share, easy life!
✔"Whiten" option to whiten teeth and skin
✔"Smooth" option to weaken wrinkles and pimples
✔ "Compare" option to view beautification effect conveniently
✔ Smooth UI and operation
✔ Quick share to Facebook or send via iMessage
Chat for Instagram
Here on Chat for Instagram you can explore some brand new friends, you can view the nearby users who share the same interests with you, and the most important thing is that you can make friends with them.
- Sign in with Instagram Account, NO registration
- Explore new friends automatically
- View nearby users no matter where you are
- FREE to say Hi to any Instagram user, you can type text message, send an audio note or send an image
- FREE to browse anyone's profile with NO restrictions
- If you like, you can bring him/her a surprise WITH sending a private note
- With block list and report features you will be well protected
Remember that no matter what is happening, or what will happen, just keep an optimistic mind, making as many friends as you can. They makes your life colorful and meaningful. They are your treasures and that no one can steal.
DOWNLOAD the app, and start your new journey.
Sex Positions
We have collected the sex positions for different users so you can choose the variants that suit you perfectly. You will feel the result immediately. Making love works hot and magic!
The free application is easy to use. Sex positions are presented visually, so you can imprint them in your mind to reproduce them later in the bedroom.
The features of the app:
* Pictures clearly show what you should do.
* Easy sharing with friends.
* Division into categories.
* Intuitive interface.
* Add to Favorites.
* Convenient to use.
* Free!
It will impress your darling and she will ask for more. The app "Sex positions" (called "Kama Sutra") makes you feel hot and desired.
It is simple to find the desirable position as they are divided into categories. Look at the categories that are offered:
1. Head to Toe.
2. Kneeling.
3. Man on Top.
4. Oral.
5. Seated.
6. Side by Side.
7. Standing.
8. Woman on Top.
It is time to get to know each other physically better using this app. Download it to enhance your sexual life and strengthen the relationship with your darling. You should not underestimate the power of Kama Sutra. The positions we offer have been highly assessed by millions of couples. Join the world of passion with help of our free app.
As previously notified, the ChatON service will no longer be available from [Feb 1, 2015, KST] ("Effective Date"), with the exception of the service in the United States.
- You can still access and save your chat history (text only) on your device by using the back-up function, provided that you have not deleted each relevant chat room.
- All your personal information will be treated in accordance with our privacy policy.
We appreciate your support for our services, and our Customer Support team (http://help.content.samsung.com) will be available to assist you with any questions or concerns.
Thank you,
The ChatON Service Team
Viber is compatible with and optimized for Android tablets! Use Viber on your tablet and phone simultaneously.
On Viber, your phone number is your ID. The app syncs with your mobile contact list, automatically detecting which of your contacts have Viber.
• Text with your friends
• Make free phone and video calls with HD sound quality
• Share photos, video messages, voice messages, locations, stickers and emoticons
• Create group messages with up to 100 participants
• Follow Public Chats – get on the inside with your favorite personalities; watch their conversations unfold in real-time, 'like' comments and share multi-media content
• Play games with Viber characters, Violet and Legcat. See how many coins you can earn
• Download stickers from the Sticker Market. Sort and reorder your stickers.
• Push notifications guarantee that you never miss a message or call, even when Viber is off
• Integration with native contact list for calls and messages
• Support for the Viber Desktop application on Windows and Mac
Localized to: Arabic, Catalan, Chinese (SP), Chinese (TR), Croatian, Czech, Danish, Dutch, Finnish, French, German, Greek, Hebrew, Hindi, Hungarian, Indonesian, Italian, Japanese, Korean, Malay, Norwegian, Polish, Portuguese (BR), Portuguese (PT), Romanian, Russian, Slovak, Spanish, Swedish, Tagalog, Thai, Turkish, Ukrainian and Vietnamese
Viber is completely free with no advertising.
We value your privacy.
Follow us for updates and news:
Facebook - http://facebook.com/viber
Twitter - http://twitter.com/viber
(*) Network data charges may apply
Telegram seamlessly syncs across all of your devices and can be used on desktops, tablets and phones alike. You can send an unlimited amount of messages, photos, videos and files of any type (.doc, .zip, .pdf, etc.). Telegram groups have up to 200 people and you can send broadcasts to up to 100 contacts at a time. Be sure to check our website for a list of Telegram apps for all platforms.
We built Telegram to make messaging speedy and safe again, without the usual caveats.
Why Switch to Telegram?
FAST: Telegram is the fastest messaging app on the market because it uses a distributed infrastructure with data centers positioned around the globe to connect users to the closest possible server.
SECURE: We made it our mission to provide the best security among mass messengers. Telegram heavily encrypts all your data with time-tested algorithms.
CLOUD STORAGE: Telegram seamlessly syncs across all your devices, so you can always securely access your data. Your message history is stored for free in the Telegram cloud. Never lose your data again!
GROUP CHAT & SHARING: With Telegram, you can form large group chats of up to 200 members, send broadcasts to up to 100 contacts at a time, quickly share large videos, documents (.doc, .ppt, .zip, etc.), and send an unlimited amount of photos to your friends.
RELIABLE: Built to deliver your messages in the minimum bytes possible, Telegram is the most reliable messaging system ever made. It works even on the weakest mobile connections.
100% FREE & NO ADS: Telegram is free and will always be free. We are not going to sell ads or introduce subscription fees.
PRIVACY: We take your privacy seriously and will never give third parties access to your data.
For those interested in maximum privacy, Telegram offers Secret Chats. Secret Chat messages can be programmed to self-destruct automatically from both participating devices. This way you can send all types of disappearing content — messages, photos, videos and even files. Secret Chats use end-to-end encryption to ensure that a message can only be read by its intended recipient.
SUPPORT: For real-time support, please go to Settings in Telegram and select "Ask a Question" to send a message directly to our support volunteers. You can also email us at firstname.lastname@example.com.
WhatsApp Messenger
★ NO HIDDEN COST: Once you and your friends download the application, you can use it to chat as much as you want. Send a million messages a day to your friends for free! WhatsApp uses your Internet connection: 3G/EDGE or Wi-Fi when available.
★ MULTIMEDIA: Send Video, Images, and Voice notes to your friends and contacts.
★ GROUP CHAT: Enjoy group conversations with your contacts.
★ NO INTERNATIONAL CHARGES: Just like there is no added cost to send an international email, there is no cost to send WhatsApp messages internationally. Chat with your friends all over the world as long as they have WhatsApp Messenger installed and avoid those pesky international SMS costs.
★ SAY NO TO PINS AND USERNAMES: Why even bother having to remember yet another PIN or username? WhatsApp works with your phone number, just like SMS would, and integrates flawlessly with your existing phone address book.
★ NO NEED TO LOG IN/OUT: No more confusion about getting logged off from another computer or device. With push notifications WhatsApp is ALWAYS ON and ALWAYS CONNECTED.
★ NO NEED TO ADD BUDDIES: Your Address Book is used to automatically connect you with your contacts. Your contacts who already have WhatsApp Messenger will be automatically displayed.
★ OFFLINE MESSAGES: Even if you miss your push notifications or turn off your phone, WhatsApp will save your messages offline until you retrieve them during the next application use.
★ AND MUCH MORE: Share location, Exchange contacts, Custom wallpaper, Custom notification sounds, Landscape mode, Precise message time stamps, Email chat history, Broadcast messages and MMS to many contacts at once and much much more!
We're always excited to hear from you! If you have any feedback, questions, or concerns, please email us at:
or follow us on twitter:
When roaming, additional carrier data charges may apply. Please contact your carrier for details.


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Comfort Inn & Suites
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
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TravelPod Member ReviewsComfort Inn & Suites Watertown
Our room was comfortable enough. The walls were thin and we were actually bothered by the TV in the room next door. I was impressed the hotel provided separate receptacles for recycling. We did not get the free bottled water that we had become accustomed to but there was a microwave and refrigerator in the room, not that we could put them to use with one night's stay. The WiFi was fine, important to my husband. The first hotel of our tour to offer complimentary breakfast! Yay!
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews Comfort Inn & Suites Watertown
Travel Blogs from Watertown
Millionaire's Row Tour, Thousand Islands
"In a sense, each of us is an island. In another sense, however, we are all one. For though islands appear separate, and may even be situated at great distances from one another, they are only extrusions of same planet, Earth."
-J. Donald Walters
Breakfast at Tony Roma's again and then we had to get an early start due to facing a no- …
A lay day and pictures of the boat museum for Dad
I am sitting on the back deck overlooking the bay listening to the lapping of the water which must be from ships moving out in the lake as it is not tidal. The river Lawrence which flows into Lake Ontario is governed by locks and the water level is set at a certain height. I understand that because of the precipitation over the summer months that the locks will allow more ...
A busy day
Today Perce and I had our hair cut and I had my nails done as well. We then met Cathy, Bill, Mike and Ruth-Anne for lunch then Mike and I went and played 9 holes of golf. It is a beautiful, sunny day, no breeze and unusual weather for this time of ...
1000 Island lake tour
We woke to an overcast day and set out for Alexander Bay to board a 3.5 hour tour around the Lake of a 1000 Islands, a must see. We bought our lunch to go from Jack Subs (similar to Subway). The day fined up and by the time we got off at Bolt Castle it was a beautiful day. At the turn of the century, George C Bolt, millionaire proprietor of the world famous Waldorf Astoria Hotel in New York, set out to build a ...
Clayton and a Lake Ontario
This morning Perce went for his walk, however, it was a little too cold and windy for me to join him. There was also a heavy fog over the lake and we could only see about 50 metres from the shore. We were hoping that the weather would change considerably so that we could do what we had planned, we weren't disappointed. After breakfast we had time to do our washing before Cathy and Bill picked us up to go to the town of Clayton Harbour for lunch and ...


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Book your room at Best Western Dubai Macae
Standard Twin Room, 2 Single BedsMax Occupancy: 2 guests (up to 1 child)
Standard Double Room, 1 Queen BedMax Occupancy: 2 guests (up to 1 child, 1 infant)
Standard Single Room, 1 Queen BedMax Occupancy: 1 guest
Macae hotel with an outdoor pool
Situated in the city center, this hotel is close to Shopping Plaza Macae Mall, Cavaleiros Beach, and Macae City Park. Local attractions also include Imbetiba Beach and Church of Sant'Anna.
Hotel Features
In addition to a restaurant, Best Western Dubai Macae features an outdoor pool. Other amenities include a bar/lounge and complimentary wireless Internet access.
Room Amenities
LCD televisions come with cable channels. Guestrooms also feature complimentary wireless Internet access, air conditioning, and safes.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Best Western Dubai Macae features an outdoor pool and a fitness center. The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. Guests can enjoy a complimentary breakfast each morning. High-speed wireless Internet access is complimentary.
A 24-hour business center is on site at this 3.5-star property. This Macae hotel also offers multilingual staff, 24-hour room service, and a safe deposit box at the front desk. Onsite self parking is complimentary.
- 24-hour front desk
- Total number of rooms - 109
- Number of floors - 7
- Bar/lounge
- Free breakfast
- Elevator/lift
- Fitness facilities
- Free WiFi
- Multilingual staff
- Luggage storage
- Restaurant
- Safe-deposit box at front desk
- 24-hour business center
- Free self parking
- Outdoor pool
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Air conditioning
- Phone
- Minibar
- Daily housekeeping
- Private bathroom
- Hair dryer
- Shower only
- In-room safe
- Desk
- Rollaway/extra beds available
- Cable TV service
- Free WiFi
- Room service (24 hours)
- Free cribs/infant beds
Where to Eat
A complimentary buffet breakfast is served each morning between 6 AM and 10 AM.
Onsite venue - This restaurant serves breakfast, lunch, and dinner.
24-hour room service is available.
Nearby Things to Do
Recreational amenities at the hotel include an outdoor pool and a fitness center.
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
- Accessible path of travel
- In-room accessibility
- Roll-in shower
Hotel Policies
Check-in time starts at noon
Check-out time is noon
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Only service dogs are allowed
- Rollaway beds are available for an additional fee
We should mention
Parents traveling with a child under 18 must present the child's birth certificate and photo ID (passport for foreign visitors) upon check-in. If only one parent or legal guardian is traveling with the child, that parent or legal guardian must also present a notarized consent of travel signed by both parents. Visitors who plan to travel with children should consult with a Brazilian consulate office prior to travel for further guidance.


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