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Pac-12: Arizona Wildcats
4Pac: Century's most memorable Pac-12 upset?
We're in the midst of the NCAA tournament, that time of the year when upset wins (and losses, depending on one's perspective) define the month's sporting calendar. To mark the occasion, Ted Miller ranked the top 10 Pac-12 football bracket busters since the turn of the century.
Stanford's 24-23 shocker at USC was technically the biggest upset of them all -- the Cardinal were 41-point underdogs -- but which surprise was the most memorable?
Kevin Gemmell: No. 14 Stanford 17, No. 2 Oregon 14, 2012
Of the "Pac-12" era, you'd be hard-pressed to find a more memorable upset than Stanford's 17-14 overtime win over Oregon in Eugene in 2012.
You had the Zach Ertz touchdown catch (or non-catch … talk amongst yourselves). You had a Stanford team adjusting to life after Andrew Luck and Kevin Hogan making his first career road start and just his second start overall. You had an Oregon team that had scored at least 42 points in 13 consecutive games. You had Jordan Williamson's Fiesta Bowl redemption and you had a Stanford defense that was downright brilliant.
Oh, did we mention that Oregon was ranked No. 1 in the country (coaches' poll)?
Stanford's win busted the two-team BCS bracket wide open. And depending which lines you looked at, Oregon was favored by as many as 21.5 with an over-under of 64.5. The Cardinal couldn't beat the Ducks the year before … at home … with Luck! … so why on earth would they do it on the road with a green quarterback?
Not only was the outcome surprising, but the way the game played out was equally unexpected. The previous three years, the winner had scored at least 50 points and the loser at least 30. In 2009, Stanford won 51-42. The next two years, Oregon won 52-31 and 53-30, respectively. The 2012 edition rewrote the playbook for how teams attacked Oregon.
Everything about that game was thrilling. And Oregon fans are probably still left wondering what would have been if De'Anthony Thomas had just thrown a block?
Ted Miller: Washington 29, No. 3 Washington State 26, 2002
I covered four of our top-10 upsets but for a myriad of reasons none left a bigger impression than Washington's shocking 29-26 victory over third-ranked Washington State in the 2002 Apple Cup.
First of all, 2002 was an interesting year. For one, check out the preseason AP poll. Colorado is No. 7, Washington is No. 9 and Washington State is No. 11. Oregon and USC are Nos. 15 and 20. Yeah, that seems a bit weird. The Huskies imploded at Michigan in the season opener, tearing defeat from the jaws of victory, and never really recovered. Washington State bounced back from a loss at Ohio State to roll through the Pac-10, the signature victory over USC punctuated by a sliding Drew Dunning after he kicked the game-winning field goal. You might recall the Pete Carroll era at USC picked up after that.
Oh, and the Rick Neuheisel and Mike Price eras ended at Washington and Washington State after this season for very different reasons, though both would end up in a sort of coaching purgatory by the beginning of 2003.
As for the game, it was a remarkable back-and-forth affair, with a talented Huskies team finally playing to its potential against a Washington State team that was obviously much better. Yet you could feel Martin Stadium gasp with worry when Cougars QB Jason Gesser got hurt. If Gesser didn't get hurt, the Cougs would have coasted home, but if wishes were fishes then cows would fly.
While the game was exciting for all four-plus hours, which included three overtimes, the ending and aftermath was most remarkable (here's my column from after the game). It was decided by a controversial call that required referee Gordon Riese to explain himself on the field. That didn't go well. Cougars fans started pelting the field with bottles and anything else they could get their hands on. It was an ugly scene.
That said, I still talk about this game with Huskies and Cougars alike. Everyone who witnessed has a take on it. Some Cougs tell me they still aren't over it. And Huskies know that their program pretty much fell into an extended spiral down the toilet after this season. Their next winning campaign didn't come until 2010.
Chantel Jennings: Arizona 31, No. 2 Oregon 24, 2014
This was a pretty easy choice for me for two reasons.
First, it's the only upset on the list that I saw in person. And let's be honest: As great as it is to watch games from the comfort of your living room with friends, it doesn't come close to being able to see the thing in real life.
Second, it was the second straight year this happened. It's like the old "fool me once, shame on you; fool me twice, shame on me" adage. Only it's "Upset a team once, it's surprising; upset a team in back-to-back years, and it doesn't seem like much of an upset anymore."
Would we even be having a debate like this if any of the other upsets had happened twice in a row? Can you imagine the chaos that would've broken loose if Stanford had beaten USC again in 2008? (Instead, the Cardinal lost by 22.) Or, what if the Beavers came back in 2009 and beat up on the then-fourth-ranked Trojans again? (They almost did, only losing by six.)
Hands down, those would be memorable, right? Because there's something so great about that moment in which an upset or a second upset spurns a rivalry and the game is never the same. Every junior on Oregon's roster this season is going to be telling the freshmen and sophomores about how they've never beaten the Wildcats in the regular season. Every senior is going to be telling the underclassmen how they want to leave Eugene without the stigma of allowing Arizona to be a stumbling block in the regular season. The difference between avenging a loss and making the same "mistake" twice is something that never leaves these players.
If Oregon had come back and smacked Arizona last year during the regular season, that wouldn't be the case.
David Lombardi: Stanford 24, No. 2 USC 23, 2007
This was my first foray to the Coliseum, and it happened to feature the largest point spread (41) ever overcome in college football history.
I spoke with only one optimistic Stanford supporter before the game, and that happened to be Jim Harbaugh's fiancée (now wife), Sarah.
The USC dynasty was flying high -- the Trojans still had two more Rose Bowl championships on the way, including one later that season. It seemed as if Stanford hadn't advanced past its 1-11 nadir the year prior. In fact, a week before their trip to Los Angeles, the Cardinal had been blown out 41-3 at home by Arizona State. To further stretch out a long injury list, starting quarterback T.C. Ostrander had suffered a seizure during the week. So Stanford threw skinny sophomore backup Tavita Pritchard to the lions of the Coliseum for his first career start.
Just a few months earlier, Harbaugh had already verbally chest-bumped Pete Carroll, who was then the bully on the Pac-10 block. "We bow to no man, we bow to no program here at Stanford University," the Cardinal's new coach had said to conclude a war of words between the two men, which began when Harbaugh publicly speculated on Carroll's future at USC.
In short, all context suggested that the Trojans would administer a beatdown to put Harbaugh and his overmatched squad in its place.
At halftime, though, USC only led 9-0, and the crowd booed the home team off the field after Stanford had stuffed a fourth-down attempt at the goal line. That was the first in a series of dominoes that fell the Cardinal's way.
Every single break proved instrumental in the upset. Trojan quarterback John David Booty, who remained in the game despite breaking his finger, threw four critical interceptions. Richard Sherman (yes, that Richard Sherman, still a wide receiver playing for Harbaugh and not Carroll back then) converted a do-or-die fourth-and-20 by a millimeter or two.
That set the table for the decisive fourth-and-goal fade, in which Pritchard found Mark Bradford -- whose father had recently passed away -- for the score that pushed Stanford to a 24-23 victory. The Cardinal had sucked the air out of the Coliseum in a shocker that might have cost USC a national title shot in 2007 and ignited the Harbaugh-Carroll rivalry.
Defense 3-headed monsters: Pac-12 South
You remember the three-headed monster, right? It's about returning production that will scare -- terrify! -- opponents. Or not.
On offense, it's elite combinations at quarterback, running back and receiver.
On defense, it's elite combinations of a leading tackler, a leader in sacks and a leader in interceptions.
We tackled offensive trios for the North and the South on Tuesday. This morning, we looked at the defensive situation in the Pac-12 North, which looks to be a rebuilding adventure across the board. Here's a glimpse at the Pac-12 South, which looks like it may be in better shape than the North. There also seems to be some defensive parity across the board in this division, so keep that in mind when considering these rankings. There's no clear standout.
1. Utah
LB Jared Norris, DL Hunter Dimick, LB Gionni Paul
The skinny: The Utes will certainly miss Nate Orchard's beastly productivity (18.5 sacks, 21 TFL), but this strong defensive machine looks to keep on churning. Norris led last year's team with 116 tackles -- the next most productive player after Orchard accumulated only 61. Utah will turn to Dimick (10 sacks, 14.5 TFL) to pick up some pass-rush slack, while Paul's four interceptions paced the roster in 2014.
2. Arizona
LB Scooby Wright, S William Parks, CB Cam Denson
The skinny: To begin, let's establish that Scooby Wright alone delivers the statistical output of an entire three-headed monster: 163 tackles, 19 TFL, 14 sacks and six forced fumbles in 2014. It's remarkable to realize that Parks' 81 tackles -- second most of Arizona's returners -- were less than half of Wright's total last year. The safety did also contribute two interceptions, as did Denson at cornerback. With Jared Tevis and Tra'Mayne Bondurant both gone, the secondary must pick up slack to round out the Wildcats' new three-headed monster.
3. Arizona State
S Jordan Simone, LB Salamo Fiso, CB Kweishi Brown
The skinny: The Sun Devils are coming off a topsy-turvy season on defense, but the bet here is that Todd Graham's maturing unit will show much more consistency in 2015. Simone has gone from walk-on to ASU's leading returning tackler and critical defensive glue. Fiso will likely have to improve upon his 11 tackles for loss from last season to help this unit overcome the pass rush loss of Marcus Hardison. Brown brings back three interceptions.
LB Anthony Sarao, LB Su'a Cravens, CB Adoree' Jackson
The skinny: Though leading tacklers Leonard Williams and Hayes Pullard are gone, plenty of exciting talent remains at USC. Sarao, now a senior, is the leading returning tackler on a balanced defense. Cravens is a true Swiss Army knife -- he's effective both in the secondary and at linebacker, evidenced by the fact he led the Trojans in both tackles for loss (17) and interceptions (3) last season. Jackson is still looking for his first career pick, but we're betting that comes soon, as his playmaking ability is not in question.
LB Myles Jack, LB Deon Hollins, CB Ishmael Adams
The skinny: This troika is tasked with filling the shoes of Eric Kendricks, perhaps the nation's most dependable tackling machine (145 last season). Jack is the unit's leading returner (87 stops in 2014), while Hollins led the Bruins with nine sacks as a sophomore. UCLA should benefit from the experience that Adams brings at cornerback. Remember that he housed two interceptions last year, and both returns were electrifying.
6. Colorado
LB Kenneth Olugbode, DL Derek McCartney, S Tedric Thompson
The skinny: The Buffs seem confident that they'll make major improvements to their atrocious run defense in 2015. That'll require a unit-wide effort originating from the front seven. But trio above represents an integral core of statistical production. Olugbode is Colorado's leading returning tackler, McCartney paced last year's team with 4.5 sacks, and Thompson recorded all three of the Buffs' interceptions in 2014.
Pac-12 morning links
And the capital of Nebraska is Lincoln!
- What if Rich Rodriguez had been a basketball coach instead? (Point guards release a collective "phew" that he isn't).
- Todd Graham has high hopes for the Sun Devils.
- Some key position battles raging at California.
- In case you missed it on the blog yesterday, Colorado and TCU have inked a home-and-home.
- Former Duck Darron Thomas is still hoping the NFL will call.
- The Beavers have extended an offer to a three-star tight end.
- Sort of Stanfordy ... Jim Harbaugh is looking for the next Andrew Luck, but knows he probably won't find him.
- How's the recruiting battle in LA going? A little something for UCLA and USC fans ... since you guys share so well.
- Dennis Dodd does a great job breaking down the newly-unsealed NCAA emails from the Todd McNair case.
- Utah opens spring ball with some position battles to keep an eye on.
- Phil Steele's spring guide is loaded with good info. Washington fans might be particularly interested in page 6.
- Any Washington State fans remember James Hasty? He was just hired as a high school head coach.
Offense 3-headed monsters: Pac-12 South
You remember the three-headed monster, right? It's about returning production that will scare -- terrify! -- opponents. Or not.
On offense, it's elite combinations at quarterback, running back and receiver.
On defense, it's elite combinations of a leading tackler, a leader in sacks and leader in interceptions.
We're breaking it down by division. We tackled the offensive three-headed monsters from the North earlier today. Now it's time to move on to the Pac-12 South, which features plenty of firepower and plenty of question marks.
1. Arizona
QB Anu Solomon, RB Nick Wilson, WR Cayleb Jones
The skinny: Perhaps the most remarkable part of the Wildcats' surge to the top of the treacherous Pac-12 South was their youth at the skill positions. Solomon led the offense as a redshirt freshman, Wilson bowled over defenders as a true freshman, and Jones led the team in receiving as a sophomore. That entire nucleus returns in 2015, and it looks like more quality depth could be layering the receiving corps -- Samajie Grant, Trey Griffey, Nate Phillips, and DaVonte' Neal come to mind. But the main point remains: Arizona returns a 1,000-yard rusher, a 1,000-yard receiver, and a developing quarterback who handled his inaugural campaign well. That's a three-headed monster that can flex its muscles in 2015.
QB Mike Bercovici, RB Demario Richard, slot receiver D.J. Foster
The skinny: There should be plenty of offensive confidence oozing out of the desert come fall. Bercovici showed plenty of dependability last season, so Todd Graham isn't waking up in cold sweats because of Taylor Kelly's graduation. Meanwhile, the Sun Devils are confident enough in Richard's running abilities to move versatile weapon Foster to the slot. Richard racked up 478 yards on 5.7 yards per carry as a 17-year old, while Foster already caught 62 passes while also serving as the primary running back last year. With Jaelen Strong's 1,165 receiving yards gone, Foster's position shift makes sense, and ASU has gunpowder in all three of its offensive cannons.
QB Cody Kessler, RB Justin Davis/Tre Madden, WR JuJu Smith
The skinny: Kessler will be in the early Heisman Trophy discussion thanks to the gaudy numbers he posted in 2014 (39 touchdowns, five interceptions), but the Trojans do have to replace his two most influential sidekicks. Running back Javorius Allen (1,489 yards) and receiver Nelson Agholor (104 catches, 1,313 yards) are both taking lavish production with them to the NFL draft. Sure, the Trojans have been recruiting well enough to power through those losses, but doing so won't be a cakewalk. Davis and Madden are expected to share backfield duties (there are promising true freshmen coming, too), while Smith returns 54 catches. There's work to do at USC to make this troika as effective as it was last year, but the cupboard certainly isn't bare -- it's brimming with potential.
QB ?, RB Paul Perkins, WR Jordan Payton
The skinny: Brett Hundley is gone from this mix, but the Bruins can take solace in the fact they return the Pac-12's rushing champion. Perkins' 1,575 yards on 6.3 yards per carry led all conference backs last year, and there will be big weight on the junior's shoulders as a new quarterback takes over. Jerry Neuheisel or Josh Rosen must develop rapport with Payton, who emerged as Hundley's favorite target in 2014. That'll be the key in ensuring that Perkins again enjoys running room in 2015.
5. Colorado
QB Sefo Liufau, RB Christian Powell, WR Nelson Spruce
The skinny: This is an intriguing trio for a Colorado program that's eager to turn a bevy of heartbreaking losses into 2015 wins. A hemorrhaging run defense might have been the primary culprit in the Buffs 1-11 finish last year, but Liufau's conference-worst 15 interceptions also cannot be overlooked. If he does a better job avoiding these mistakes, Spruce and an improving run game should be ready to roll. Spruce's 106 catches led the Pac-12 in 2014, while Colorado's rushing efficiency has bettered from 3.1 yards per carry in 2012 to 4.1 last year. Powell, a 230-pound bruiser, led a committee of backs at 5.3 yards per carry.
6. Utah
QB Travis Wilson/Kendal Thompson, RB Devontae Booker, WR Kenneth Scott
The skinny: The Utes have Booker, a 1,512-yard name that'll be tossed around in early Heisman discussions, but there has to be significant worry beyond his position. For one, both prospective quarterbacks struggled throwing the ball last season, and their road doesn't look to be getting any smoother. With Kaelin Clay, Dres Anderson, and Westlee Tonga gone, the Utes are losing two of their top three receivers and their most productive tight end. Scott is the leading returning target while prized junior college transfer Deniko Carter will be counted on to produce immediately. There's potential there, but at this point, questions outweigh answers. Booker is the workhorse with a hefty load on his shoulders.
Pac-12 morning links
You talkin' to me?
Colorado has finished their spring game, so we're in a slight Pac-12 practice lull while basketball is in the spotlight. But the avalanche of 11 other spring games is creeping closer. Here are some links from around the conference:
- Rich Rodriguez has netted the commitment of a three-star running back.
- The Arizona State staff says that it needs an improved Mike Bercovici at quarterback in 2015.
- A recap from the latest Cal football spring practice, courtesy California Golden Blogs.
- More on the life and death of former Colorado lineman Ryan Johanningmeier.
- Oregon kicks off spring practice in less than a week. Here's a preview.
- Details have been announced regarding Oregon State's spring game on April 18, while the Beavers have grabbed another 2016 commitment.
- Last week, Stanford coach David Shaw spoke about his former boss and a young quarterback prospect named Jameis Winston.
- As UCLA gears up for spring practice, here are some Bruin Bites.
- The latest USC football morning report from the Los Angeles Times.
- Five burning questions about Utah football -- answered.
- A Washington football mailbag tackles the Huskies' quarterback competition.
- Washington State needs a new director of player relations.
Pac-12's big day led by Ground Zero prospects
Pac-12 morning links
Vanity. Definitely my favorite sin.
- The Wildcats wide receiving corps should be strong again.
- Speaking of receivers, ASU feels like it's got a pretty good stable as well.
- Some post-practice thoughts and analysis from Cal.
- Some good Colorado football Qs and As from Kyle Ringo's chat.
- Highlights from Marcus Mariota's QB Camp with Jon Gruden.
- Oregon State is keeping its eye on this JC cornerback.
- A preview of Stanford's pro day.
- UCLA loading up on linebackers.
- Former USC running back Reggie Bush is headed back to the West Coast.
- Would Eric Rowe be a good fit in Baltimore?
- Jake Browning could make an instant impact for Washington.
- Connor Halliday is on this list of the top 10 quarterbacks in the draft.
Spring position breakdown: Pac-12 South defensive backs, Part I
With spring practice underway at many Pac-12 destinations, it's time to do our annual position-by-position breakdown.
Today, we move to the defensive side of the ball and we're starting with the defensive backs. For the sake of time and avoiding headaches, we're going to just separate this into three groups -- the defensive backs, linebackers and defensive line. For teams that have certain hybrid positions and players, we put them into which of those three categories we thought they best fit. If you don't like how we did it, feel free to complain here.
Arizona: Cornerback Jonathan McKnight is out, leaving the Wildcats down a corner. The good news is that Jarvis McCall Jr. is back after finishing last season as Arizona's ninth-leading tackler. Three players will try to battle it out to start opposite McCall: Cam Denson, Devin Holiday and DaVonte' Neal. Denson is the most experienced, having started at CB against UCLA and Colorado and finishing the year with 21 tackles and two picks. Holliday played in just six games and finished with two tackles and one interception, while Neal has come over from the offensive side of the ball to help out with depth at the corner spot. All three are in similar physical molds to McKnight but this is going to come down to who can make the most plays. Whoever comes out on top this spring has a fast track to the starting job next fall so these reps are crucial.
However, the Wildcats aren't as fortunate in the rest of the secondary, where they lost Jourdon Grandon, Tra'Mayne Bondurant and Jared Tevis. Will Parks should fill Bondurant's spot at spur pretty well, but he needs to bring the leadership of Bondurant and Tevis combined. Jamar Allah, Tellas Jones and Anthony Lopez will fight for minutes this spring alongside juco transfer Paul Magloire Jr., who has already received some praise from Rich Rodriguez. The quarterback turned running back turned safety enrolled early and with so many open reps and so few more opportunities left in his college career, look for him to make the most of this.
Arizona State: The Sun Devils return most of their secondary, but lose boundary safety Damarious Randall, who led ASU in tackles last season and tallied three interceptions. Replacing him will be no small task but Todd Graham has options in James Johnson, Chad Adams and Dasmond Tautalatasi. Whoever earns that starting spot will have the opportunity to work and grow alongside field safety Jordan Simone, who had a breakout year in 2014 after going from walk -on to scholarship player and he'll look to build on that momentum. And at corner, the Sun Devils return both starters in Lloyd Carrington and Kweishi Brown as well as nickel Armand Perry. So, don't be too worried if those three don't get a ton of reps this spring because their spots are secure and now Graham is just looking to build some depth. Perry should get a few more reps as will Solomon Means and Ronald Lewis, as they try to break into the cornerback rotation.
Colorado: The Buffs are in a slightly different position here considering they concluded spring practices yesterday. But here's a run down based off the notes from the spring game that were released as well as some thoughts that led to the event. The depth chart has Ken Crawley (who's up to 180 pounds) and Chidobe Awuzie listed as the two top cornerbacks. Behind them are John Walker -- who won the team's award as the most improved defensive back -- and Ahkello Witherspoon in the two deep. Awuzie was kind of a surprise to see atop the list considering how much praise we've heard about the rangy Witherspoon but considering that Awuzie is also listed as the starting nickel, we're still expecting to see a lot of Witherspoon at corner. At safety, Evan White and Tedric Thompson took the starting jobs while Ryan Moeller and Afolabi Laguda fill out the two deep.
Anu Solomon not getting too comfortable
Wildcats quarterback Anu Solomon seemed to have digested that lesson. Despite being a redshirt freshman, he'd led Arizona to a 6-1 record in the 2014 regular season in games decided by eight or fewer points, including a victory at then-No. 2 Oregon in his first career Pac-12 road start. Sure, he hadn't always been on point for all four quarters in every game, but he'd been a key part of a team that found ways to win.
After a nearly three minute drive -- glacial by Arizona standards -- the Wildcats had the ball on the Boise State 8-yard line. No timeouts.
"We're down by eight," Solomon recalls, stepping in when a reporter pauses. "We have 16 seconds to go. I was aware of the situation. Third down, if I don't have anything, throw it away we get another shot. We did a roll-out play and I didn't see anything. But being the true competitor I am… All I can say is I wanted to do everything myself, to make something out of nothing. I was not being smart at that time. Right now, I'd take it back. But I can't."
Solomon held the ball too long, waiting for a crack in the Broncos defense that never appeared. Instead, he was sacked by Kamalei Correa for a 2-yard loss and the clock hit zero, a fantastic season ending on a dreary, "What the Heck Was He Thinking?" note.
Not yet comfortable being uncomfortable? Said Solomon, "It was that exact thing."
Solomon had a good year by most definitions, particularly when you again note he was a redshirt freshman. He passed for 3,793 yards with 28 touchdowns and nine interceptions and rushed for 552 yards and two scores for a team that surprised many by winning the Pac-12's South Division.
Yet Solomon struggled over the second half of the season. Through the first seven games, he completed 63.3 percent of his passes with 20 touchdowns and four interceptions. Over the next seven, he completed 50.4 percent of his throws with eight TDs and five picks.
Sure, the second-half schedule was tougher. And, sure, Solomon was playing through multiple injuries -- "foot, knee, ankle," he said. But there's a reason Rodriguez has talked about Solomon this spring as if he's in another QB competition rather than being the first returning starter behind center Rodriguez has had in Tucson.
Solomon needs to get better if the Wildcats are going to continue to climb in the rugged South and again become a nationally relevant team.
As for injuries being the main culprit, Solomon parrots Rodriguez and offensive coordinator Rod Smith.
"I don't want to use the injuries as an excuse," he said. "My brain wasn't injured."
So Solomon isn't shying away from the idea that he needs to distinguish himself from Brandon Dawkins and Jerrard Randall this spring. He has added a few pounds to his 6-foot-2, 205-pound frame from last fall, and he set a team QB record with a 325 pound bench press while running a 4.6 40-yard dash.
"Nothing is guaranteed in life," he said. "Every year in sports you have to earn your spot. As of right now, jobs are open and I'm competing for that spot."
As for areas of emphasis, Solomon said his pocket presence, accuracy, decision-making and leadership are where he most needs to focus. While Arizona had one of the nation's deepest crews of receivers last year, Solomon admits he and his wideouts didn't develop an intuitive connection, particularly when plays broke down and there was some necessary improvising. A not-infrequent visual was senior Austin Hill gesticulating back toward Solomon after a pass flew off the mark.
"We struggled a lot last season being on the same page," Solomon said.
While the Wildcats are filling three holes on the offensive line, the skill players around Solomon, including running back Nick Wilson and receivers Nate Phillips, Cayleb Jones, Samajie Grant, Trey Griffey and David Richards, are A-list. It's difficult to imagine that, after averaging nearly 35 points per game last year, an improved Solomon wouldn't give Arizona one of the nation's most potent offenses.
As for Rodriguez continuing to, er, help Solomon become comfortable being uncomfortable, as of Wednesday the QB said Rodriguez has yet to unleash one of his trademark epic tirades.
"Not yet," Solomon said. "He's baby stepping his way there."
In-state recruiting still vital for Pac-12 programs
California will always be the first and last stop for Pac-12 coaches on the recruiting trail. In the 2015 class, 129 prospects from the Golden State signed with Pac-12 schools and no conference program signed fewer than five.
But for Pac-12 programs outside of California, particularly in the next three talent producing states of the West region -- Arizona, Utah and Washington -- locking up the borders can be a vital part of an eventual run at a conference, or even national, championship.
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Spring position breakdown: Pac-12 South WRs
We're making our way through the offensive position groups and today we get to wide receivers. Let's begin with the South ...
Arizona: The Wildcats could have one of the most electric passing attacks in the Pac-12 next season with Anu Solomon and his crop of returning receivers. Arizona has five of its top seven receivers returning with the only Cats out being Austin Hill, who graduated, and DaVonte' Neal, who's still on the roster but moved over to defense. But between Cayleb Jones, Samajie Grant, Trey Griffey, Nate Phillips and David Richards, there's going to be a lot of competition for catches this spring. Also, according to this report, there are a few 2014 scout team players who've impressed wide receivers coach Tony Dews so far this spring -- Tony Ellison, Kaelin DeBoskie, Jocquez Kalili and Darius Aguirre.
Arizona State: D.J. Foster will have his first full WR spring this year after being the second-leading receiver for the Sun Devils last year. Past Foster, the only other player who had significant receiving experience last season was Cameron Smith, who caught 41 passes for ASU. Look for these two to solidify their roles as starters, but they'll also have competition from Gary Chambers, Frederick Gammage, Ellis Jefferson and former JUCO transfer Eric Lauderdale.
Colorado: Nelson Spruce deciding to come back for his final year of eligibility might be one of the biggest returns -- from a team's own stock perspective -- in the league this year. This spring, expect him and Sefo Liufau to keep building that chemistry, especially considering Mike MacIntyre told reporters that he could see Spruce having another 100-reception season, which would make him the first Pac-10/Pac-12 player in history to have two 100-reception seasons. Shay Fields and Bryce Bobo will duel it out for the opportunity to get those non-Spruce balls as the Buffaloes attempt to replace the production of Tyler McCulloch and D.D. Goodson.
UCLA: The Bruins return their top six receivers from last year so since Jim Mora has plenty of experience returning, expect this spring to be a lot of experimentation with different formations for those top guys, while also building depth with lesser-known players. Is there a chance that Mora could go crazy and pull a Mike Leach and throw four (maybe five?) receivers out there on a single down? He certainly has the talent and depth to do so. Jordan Payton will be the Bruins' go-to, but past him Devin Fuller, Thomas Duarte, Eldridge Massington, Mossi Johnson, Devin Lucien and Kenneth Walker are more than capable. Better yet for the Bruins, all of those receivers except Walker, are at least 6-foot, giving UCLA serious opportunities for mismatches downfield. But Walker, even though he might be vertically challenged compared to his receiver teammates, is known as one of the fastest (if not the fastest) on the team, so he creates mismatches of his own. Long story short: The Bruins are going to have a strong spring full of veteran players who will be impact players come fall.
USC: The Trojans lost a lot when both Nelson Agholor and George Farmer decided to leave early for the NFL. Add to that 41-catch RB Buck Allen and USC has a lot of shoes to fill. But fear not, they seem to have the numbers to do it. JuJu Smith returns and he'll become Cody Kessler's go-to receiving weapon. This spring will be spent building trust and chemistry between those two as Kessler adapts to the post-Agholor era. Past Smith, Adoree' Jackson, Darreus Rogers and Steven Mitchell will have a lot to prove after showing flashes last fall. On top of those four familiar faces, the Trojans welcome early enrollee JUCO transfer Isaac Whitney, who could boost the USC wide receiver corps. At 6-foot-4 Whitney towers over most other wide receivers and though spring will be his first reps with the Trojans (meaning he might be slower to start because of the new-ness of everything) he could be a guy that makes monstrous gains this spring and summer.
Utah: Last year the Utes finished last in the Pac-12 in passing yards per game. Heading into this spring the Utes lost three of their four top receiving threats, so to say that players need to step up is a bit of an understatement. One of the problems last fall was the quarterback rotation, so it was hard to build chemistry when a new face popped up every game behind the offensive line. This spring, that problem will still exist since Kendal Thompson is out, so the Utah receivers need to do the best they can to just build depth with a question mark still at the QB spot. Utah can't afford to be a singular attack (read: Devontae Booker) come fall. Kenneth Scott will look to step up as the go-to receiver while Tim Patrick and Delshawn McClellon spend the spring battling for those No. 2 and No. 3 receiving spots before junior college transfer Deniko Carter (No. 8 WR in the 2015 JUCO class) gets to campus this summer and tries to climb the ladder himself.
Spring position breakdown: Pac-12 South RBs
Yesterday we began with the quarterbacks. Today, we move onto running backs. Starting in the South…
Arizona: Rich Rodriguez said that even though running back Nick Wilson is fully recovered he won't be going through any full-contact drills this spring since there's no need for him to prove he can get hit and still be effective. He already did that this past fall when he led Pac-12 freshmen and was the conference's fourth-leading rusher. But with Terris Jones-Grigsby gone, there are a few players who do need to get hit and prove that they can make up for some of the lost yardage. Two names to watch: Jared Baker and Jonathan Haden. And with Wilson out of contact drills, expect some younger players' names to crop up as Rodriguez gives carries to guys who'll be more involved on scout team come fall.
Arizona State: With D.J. Foster's move to receiver, alleviating some of the post-Jaelen Strong era pains, there will be plenty more carries with the Sun Devils. In February, quarterback Mike Bercovici predicted that Demario Richard would probably come out as ASU's starting running back next season. Richard comes in a similar mold to Foster (Richard is 5-foot-10, 210 pounds while Foster is 5-foot-11, 205 pounds). Richard caught 13 passes and had 84 carries last season, so he can be counted on as a passing-catch running back. But, don't expect Kalen Ballage to take Richard's promotion (through Bercovici's eyes) sitting down. Todd Graham spoke very highly of Ballage last season and Ballage's 96-yard kick return in the Hyundai Sun Bowl is what set up Richard's game-winning TD. This battling duo will be fun to watch this spring.
Colorado: The Buffs had four running backs with 75-plus carries last season and quarterback Sefo Liufau toted the ball 69 times, too, but past those five players there really was no one else on the running back radar for Mike MacIntyre. Christian Powell, Michael Adkins II and Phillip Lindsay are all back for Colorado, but only Powell is full go for the spring. McIntyre told reporters in February that Lindsay is day-to-day and Adkins could be out until the middle of spring, leaving Powell with the brunt of carries and the rest going to whoever doesn't have a turf-toe or knee injury. George Frazier, Jordan Murphy and Kyle Evans are all names we could hear this spring but mostly because of said personnel problems.
UCLA: Paul Perkins, ladies and gents. There's not a whole lot else Bruin fans need to (or want to) think about when it comes to running backs. After leading the Pac-12 in rushing in 2014, he's back and ready to make even bigger strides. With Brett Hundley and Jordon James gone, there will be some serious yardage that needs to be made up in 2015. Perkins can take a lot of it, but it'd be nice if Nate Starks had a big spring for the Bruins so he could be counted on next fall to take the load of Perkins' shoulders every so often. And, stop me if you've heard this once before: it should be interesting to see what Jim Mora does with Myles Jack. He carried the ball 28 times for UCLA last fall but will all the back-up eggs be put in Starks' basket? Or will Jack remain an occasional running-backer -- giving the Bruins a few more options in short-yardage situations? And does that change how the spring looks for the Bruins or Jack?
USC: Tre Madden might still be nursing a turf toe injury, but if he is 100 percent, it'll be a fun spring season for USC run game coordinator Bob Connelly as he watches Madden and Justin Davis square off to be the top running back. The winner will have the upper hand this fall when USC sees an influx of young talent. If Madden is healthy, you've got a player whose career has been plagued by injuries vs. the 2014 back up -- chip on the shoulder vs. chip on the shoulder. This could get spicy. And, if Madden isn't full go, then it'll mostly just be a lot of reporting on guys who'll probably be next year's third- or fourth-string running backs. Yay spring ball.
Utah: Like Arizona and UCLA, the Utes have their No. 1 guy locked up in Devontae Booker, who took the 2014 season by storm and finished as the conference's second-leading rusher. After a full winter of strength and conditioning, how much more polished will he look? Utah also returns back up Bubba Poole and third-stringer Troy McCormick, who will probably retain those same roles this spring. The Utes are sitting pretty at running back.
Poll: Which Pac-12 team drops the most?
Well, since we're so balanced here at the Pac-12 Blog, we couldn't possibly look at what team will elevate itself without looking at what ranked team could plummet in the rankings.
Schlabach's Way Too Early Top 25 will make the biggest drop (or not even make the top 25) at the end of the 2015 season?
1. USC | Schlabach's rank: No. 3
Schlabach's reasoning for putting the Trojans so high is understandable: They've got great depth and finally signed a full recruiting class (which was full of blue-chip talent). That's a good recipe for success -- a returning QB, depth, some good juco transfers. But a lot of that talent is untested. Can USC really replace the production of Buck Allen and Nelson Agholor in one offseason, or will the Trojans fall like Troy? (terrible pun No. 1 of 2)
2. Oregon | Schlabach's rank: 6
The Ducks return one of the deepest running back corps in the country and some pretty talented receivers, but with a question mark at quarterback and plenty of spots to fill on the defensive side of the ball, could Oregon be a team that is plagued by inconsistency and drops in the rankings? It's certainly possible. Oregon joins Alabama, Baylor, Georgia and UCLA as Way Too Early top-10 teams that need to find a new QB. Could that one position be enough to sink the Ducks? (terrible pun No. 2 of 2)
3. UCLA | Schlabach's rank: 9
Like Oregon, UCLA needs to find a QB and find it fast. The Bruins, like Oregon, also need to find a new pass rusher and some talented linebackers. Could the problems that malign Oregon also lay claim to the Bruins? But between UO and UCLA, which would be more susceptible to those problems?
4. Arizona | Schlabach's rank: 13
The bridesmaid of the Pac-12 has done a good job of showing up, just not always finishing. Arizona wasn't even mentioned in last season's Way Too Early Top 25 (the February edition) but finished the season ranked No. 19. Will the Wildcats continue this upward trend, or will they pull a Stanford/Washington, which were both ranked in the Way Too Early Top 25 but finished the season with no one talking about them?
5. Arizona State | Schlabach's rank: 18
Like the Ducks and Bruins, the Sun Devils need a new QB, but unlike Oregon and UCLA, the heir is already on the throne. And not only is Mike Bercovici on the throne, he's already stating the goals of the program -- a national title. Could Bercovici's words become fact? Or will they fall flat as ASU struggles to adjust to life in the spotlight?
Trending Five: Huskies, Wolverines making noise in Los Angeles
Hundreds of the top West region prospects were on hand for The Opening Los Angeles Regional this past Sunday. Here are five trends that were revealed during and after the event.
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Couture Fashion Designer, Seattle, Washington
I left my career as a graphic designer 11 years ago to pursue my lifelong passion for designing couture gowns – fine dresses made from the most exquisite fabrics and tailored specifically for the wearer's natural silhouette.
Some of my greatest inspiration comes from my clients, and this is especially true of a young woman whom I was fitting for a wedding gown eight years ago. As we talked, she said something that had a huge impact on me: "Seattle Children's saved my life. Without them, I wouldn't be getting married in this beautiful gown."
Her story touched my heart and I knew I wanted to learn more. After taking a tour of the hospital, I started thinking about how – in a small way – Children's and I had something in common: We're both in the business of making people's dreams come true.
With this young bride as inspiration, I decided to support the hospital by doing what I know best: designing dream garments for patients and having them model the clothes in my annual fashion show.
When the kids are backstage getting ready to walk the runway, I can literally feel their excitement. I see the joy in their faces and know how proud they are. My wish is that the way they feel on the night of the show – vibrant, beautiful and special – stays with them forever.
For weeks after a show, I am on cloud nine. Being able to create lasting memories for these children makes my own dreams as a designer come true.
Find more videos and stories of the providers, staff, supporters, patients, families, volunteers and friends who make up the Seattle Children's family.
Visit I Am Seattle Children's.
Published in Connection magazine, December 2012
3.24.15 - Seattle Children's
Seattle Children's Heart Center will hold a Family Education Day on Saturday, May 2, 2015 for current patients. The day will...cont.
3.2.15 - The Denver Post
Eliminating exemptions for religious and personal beliefs would certainly increase vaccination rates, said Dr. Douglas S....cont.
2.25.15 - Pew Research Center
Our analysis found wide variation in vaccination exemptions across the country. Some states have strict guidelines...cont.

subset: commoncrawl


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Are you H L Ozer?Claim your profile
Publications (78)459.8 Total impact
Article: Ubiquitin-mediated interaction of p210 BCR/ABL with β-catenin supports disease progression in a murine model for chronic myelogenous leukemia.[Show abstract] [Hide abstract]
ABSTRACT: We have identified a ubiquitin binding domain (UBD) within the NH2-terminal sequences of p210 BCR/ABL and determined that the binding site co-localizes with the binding site for β-catenin. The domain does not support the auto-or trans-kinase activity of p210 BCR/ABL, or its ability to interact with GRB2 and activate ERK1/2 signaling. Expression of p210 BCR/ABL, but not a β-catenin binding mutant, in hematopoietic cells is associated with the accumulation of p-β-catenin(Tyr654), and increased TCF/LEF-mediated transcription. In a bone marrow transplantation (BMT) model, the interaction between β-catenin and p-β-catenin(Tyr654) is detectable in mice transplanted with p210 BCR/ABL, but not the mutant. Whereas mice transplanted with p210 BCR/ABL exhibit myeloid disease with expansion of monocytes and neutrophils, mice transplanted with the mutant exhibit predominant expansion of neutrophils, polycythemia, and increased lifespan. The increased disease latency is associated with expansion of megakaryocyte-erythrocyte progenitors (MEPs), a decrease in common myeloid progenitors (CMPs), and reduced β-catenin signaling, in the bone marrow of the diseased mice. These observations support a model in which p210 BCR/ABL may influence lineage-specific leukemic expansion by directly binding and phosphorylating β-catenin, and altering its transcriptional activity. They further suggest that the interaction may play a role in chronic phase disease progression.Blood 08/2013; DOI:10.1182/blood-2013-01-481184 · 9.78 Impact Factor
Article: Abstract 2557: Exploring the contribution of ubiquitin binding domain of Bcr-Abl in chronic myelogenous leukemiaCancer Research 06/2012; 72(8 Supplement):2557-2557. DOI:10.1158/1538-7445.AM2012-2557 · 9.28 Impact Factor
Article: PHF10 Is Required for Cell Proliferation in Normal and SV40-Immortalized Human Fibroblast Cells[Show abstract] [Hide abstract]
ABSTRACT: Normal human diploid fibroblasts have limited life span in culture and undergo replicative senescence after 50-60 population doublings. On the contrary, cancer cells typically divide indefinitely and are immortal. Expression of SV40 large T and small t antigens in human fibroblasts transiently extends their life span by 20-30 population doublings and facilitates immortalization. We have identified a rearrangement in chromosome 6 shared by SV40-transformed human fibroblasts. Rearrangements involving chromosome 6 are among the most frequent in human carcinogenesis. In this paper, we extend analysis of the 6q26-q27 region, a putative site for a growth suppressor gene designated SEN6 involved in immortalization of SV40-transformed cells. Detailed molecular characterization of the rearranged chromosomes (6q*, normal appearing; and 6q(t), translocated) in the SV40-immortalized cell line HALneo by isolating each of these 2 chromosomes in mouse/HAL somatic cell hybrids is presented. Analysis of these mouse/HAL somatic cell hybrids with polymorphic and nonpolymorphic markers revealed that the 6q* has undergone a chromosomal break in the MLLT4 gene (alias AF6). This result in conjunction with previous published observations leads us to conclude that SEN6 lies between MLLT4 and TBP at chromosomal region 6q27. Examination of different genes (MLLT4, DLL1, FAM120B, PHF10) located within this interval that are expressed in HS74 normal fibroblast cells reveals that overexpression of epitope-tagged truncated PHF10 cDNAs resulted in reduced cell proliferation in multiple cell lines. Paradoxically, down-regulation of PHF10 by RNAi also resulted in loss of cell proliferation in normal fibroblast cells, indicating PHF10 function is required for cell growth. Taken together, these observations suggest that decreased cell proliferation with epitope-tagged truncated PHF10 proteins may be due to dominant negative effects or due to unregulated expression of these mutant proteins. Hence we conclude that PHF10 is not SEN6 but is required for cell growth.Cytogenetic and Genome Research 12/2009; 126(3):227-42. DOI:10.1159/000251960 · 1.84 Impact FactorThis article is viewable in ResearchGate's enriched formatRG Format enables you to read in context with side-by-side figures, citations, and feedback from experts in your field.
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ABSTRACT: The BCR-ABL oncogene encodes an in-frame fusion protein containing N-terminal sequences derived from Bcr and C-terminal sequences derived from Abl. Bcr contains a centrally located Rho-specific guanine nucleotide exchange factor (RhoGEF) domain that is retained within p210 Bcr-Abl. Although this domain is subject to autoinhibition in the context of Bcr, here we show that it is constitutively activated in p210 Bcr-Abl. p210 Bcr-Abl can stimulate RhoA activation independently of its tyrosine kinase activity, and mutations within the RhoGEF domain that are predicted to eliminate RhoGEF activity inhibit RhoA activation. The RhoGEF mutant of p210 Bcr-Abl does not affect the tyrosine kinase activity of the molecule, nor the ability of p210 Bcr-Abl to interact with XPB through the RhoGEF domain. Despite retaining normal levels of tyrosine kinase activity, the RhoGEF mutant of p210 Bcr-Abl is impaired in transforming activity as measured by anchorage-independent growth. However, the mutant is still able to confer the phenotype of growth factor independence in myeloid cells, suggesting that some, but not all parameters of p210 Bcr-Abl transformation, are dependent upon a catalytically active RhoGEF domain. Collectively, these observations identify a gain-of-function activity attributable to the RhoGEF domain of p210 Bcr-Abl that is required to support the transformed phenotype.Oncogene 04/2008; 27(14):2064-71. DOI:10.1038/sj.onc.1210841 · 8.56 Impact Factor
Article: Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover[Show abstract] [Hide abstract]
ABSTRACT: Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mammalian endosomal sorting complex required for transport (ESCRT), which regulates protein sorting during endosomal trafficking, this association suggests that Bcr may have a related cellular function. The docking site for TSG101 has been mapped to the COOH terminus of Bcr, indicating that this interaction may be disrupted in CML. Overexpression studies with full-length TSG101 and Bcr reveal that this interaction can be recapitulated in mammalian cells. The association can also be observed between natively expressed proteins in a panel of hematopoietic and nonhematopoietic cell lines, where a second subunit of the ESCRT complex, vacuolar sorting protein 28 (Vps28), was also found to interact with Bcr. Both Bcr and TSG101 exhibit a punctate cytoplasmic distribution and seem to colocalize in HeLa cells, which would be consistent with an in vivo association. Bacterially purified Bcr and TSG101 also bind, suggesting that the interaction is direct and is not dependent on ubiquitination. Disruption of the endosomal pathway with an ATPase-defective Vps4 mutant results in the cellular redistribution of Bcr, and suppression of Bcr in HeLa cells by small interfering RNA impairs epidermal growth factor receptor turnover. Taken together, these observations suggest that Bcr is a component of the mammalian ESCRT complexes and plays an important role in cellular trafficking of growth factor receptors.Cancer Research 07/2006; 66(12):6250-7. DOI:10.1158/0008-5472.CAN-06-0536 · 9.28 Impact Factor
Article: Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts.[Show abstract] [Hide abstract]
ABSTRACT: The regulation of the multifunctional calcium/calmodulin dependent protein kinase II (CaMKII) by serine/threonine protein phosphatases has been extensively studied in neuronal cells; however, this regulation has not been investigated previously in fibroblasts. We cloned a cDNA from SV40-transformed human fibroblasts that shares 80% homology to a rat calcium/calmodulin-dependent protein kinase phosphatase that encodes a PPM1F protein. By using extracts from transfected cells, PPM1F, but not a mutant (R326A) in the conserved catalytic domain, was found to dephosphorylate in vitro a peptide corresponding to the auto-inhibitory region of CaMKII. Further analyses demonstrated that PPM1F specifically dephosphorylates the phospho-Thr-286 in autophosphorylated CaMKII substrate and thus deactivates the CaMKII in vitro. Coimmunoprecipitation of CaMKII with PPM1F indicates that the two proteins can interact intracellularly. Binding of PPM1F to CaMKII involves multiple regions and is not dependent on intact phosphatase activity. Furthermore, overexpression of PPM1F in fibroblasts caused a reduction in the CaMKII-specific phosphorylation of the known substrate vimentin(Ser-82) following induction of the endogenous CaM kinase. These results identify PPM1F as a CaM kinase phosphatase within fibroblasts, although it may have additional functions intracellularly since it has been presented elsewhere as POPX2 and hFEM-2. We conclude that PPM1F, possibly together with the other previously described protein phosphatases PP1 and PP2A, can regulate the activity of CaMKII. Moreover, because PPM1F dephosphorylates the critical autophosphorylation site of CaMKII, we propose that this phosphatase plays a key role in the regulation of the kinase intracellularly.Journal of Biological Chemistry 07/2004; 279(23):24889-98. DOI:10.1074/jbc.M400656200 · 4.60 Impact Factor
Article: Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1.[Show abstract] [Hide abstract]
ABSTRACT: Human fibroblasts undergo cellular senescence after a finite number of divisions, in response to the erosion of telomeres. In addition to being terminally arrested in the cell cycle, senescent fibroblasts express genes that are normally induced upon wounding, including genes that remodel the extracellular matrix. We have identified the novel zinc finger protein APA-1, whose expression increased in senescent human fibroblasts independent of telomere shortening. Extended passage, telomerase-immortalized fibroblasts had increased levels of APA-1 as well as the cyclin-dependent kinase inhibitor p16. In fibroblasts, APA-1 was modified by the ubiquitin-like protein SUMO-1, which increased APA-1 half-life, possibly by blocking ubiquitin-mediated degradation. Overexpression of APA-1 did not cause cell cycle arrest; but, it induced transcription of the extracellular matrix-remodeling genes MMP1 and PAI2, which are associated with fibroblast senescence. MMP1 and PAI2 transcript levels also increased in telomerase-immortalized fibroblasts that had high levels of APA-1, demonstrating that the matrix-remodeling phenotype of senescent fibroblasts was not induced by telomere attrition alone. APA-1 was able to transactivate and bind to the MMP1 promoter, suggesting that APA-1 is a transcription factor that regulates expression of matrix-remodeling genes during fibroblast senescence.Molecular and Cellular Biology 12/2002; 22(21):7385-97. DOI:10.1128/MCB.22.21.7385-7397.2002 · 5.04 Impact Factor
Article: Termination of lifespan of SV40-transformed human fibroblasts in crisis is due to apoptosis[Show abstract] [Hide abstract]
ABSTRACT: Normal human fibroblasts in culture have a limited lifespan, ending in replicative senescence. Introduction of SV40 sequences encoding large T antigen and small t antigen into pre-senescent cells results in an extension of lifespan for an additional 20-30 population doublings. Rare clones of SV40-transformed cells are capable of indefinite growth and are described as immortal; however, the great majority of SV40-transformed cells terminate this extended lifespan in cell death, termed "crisis." We have examined the properties of cells in crisis to obtain further insights into mechanism of cell death and immortalization. Populations at the terminal cell passage show a balance between cell replication and cell death over a period of several weeks, with a progressive increase in cells undergoing cell death. During this period, there is less than a 3-fold increase in attached cell number, with two stages being identifiable on the basis of the focal pattern of cell survival. We also demonstrate that cells in crisis are undergoing apoptosis based on TUNEL assay, subG1 DNA content, annexin V reactivity, and activation of caspases 3 and 8. We suggest a model whereby SV40-transformed cells acquire increased sensitivity to apoptosis based on changes in properties which activate caspase 8 in addition to changes previously described involving shortening of telomeric sequences. While only telomere stabilization could be clearly shown to be essential for survival of cells through crisis, the extended period of cell replication and altered gene expression observed in SV40-transformed cells during crisis are compatible with other genetic alterations in immortal cells.Journal of Cellular Physiology 03/2002; 190(3):332-44. DOI:10.1002/jcp.10062 · 3.87 Impact Factor
Article: Mechanism of immortalization[Show abstract] [Hide abstract]
ABSTRACT: Model systems implementing various approaches to immortalize cells have led toward further understanding of replicative senescence and carcinogenesis. Human diploid cells have a limited life span, termed replicative senescence. Because cells are terminally growth arrested during replicative senescence, it has been suggested that it acts as a tumor suppression mechanism as tumor cells exhibit an indefinite life span and are immortal. The generation of immortal cells lines, by the introduction of SV40 and human papillomavirus (HPV) sequences into cells, has provided invaluable tools to dissect the mechanisms of immortalization. We have developed matched sets of nonimmortal and immortal SV40 cell lines which have been useful in the identification of novel growth suppressor genes (SEN6) as well as providing a model system for the study of processes such as cellular aging, apoptosis, and telomere stabilization. Thus, their continued use is anticipated to lead to insights into other processes, which are effected by the altered expression of oncogenes and growth suppressors.Journal of the American Aging Association 03/1999; 22(2):65-69. DOI:10.1007/s11357-999-0008-1 · 3.45 Impact Factor
Article: SV40-Mediated immortalization.[Show abstract] [Hide abstract]
ABSTRACT: Human diploid cells have a limited life span, ending in replicative senescence, in contrast to cell lines derived from tumors, which show an indefinite life span and are immortal, suggesting that replicative senescence is a tumor suppression mechanism. We have utilized introduction of SV40 sequences to develop matched sets of nonimmortal and immortal cell lines to help dissect the mechanism of immortalization and have found that it has multiple facets, involving both SV40-dependent and -independent aspects. These studies have led to the identification of a novel growth suppressor gene (SEN6) as well as providing a model system for the study of cellular aging, apoptosis, and telomere stabilization among other things. It is anticipated that SV40-transformed cells will continue to provide a very useful experimental system leading to insights into the behavior of cells with altered expression of oncogenes and growth suppressor gene products.Experimental Cell Research 12/1998; 245(1):1-7. DOI:10.1006/excr.1998.4272 · 3.37 Impact Factor
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ABSTRACT: SV40 infection of human cells results in both transformation and lytic infection. We have used origin-defective viral mutants which are unable to replicate in permissive cells to help analysis of transformation. Expression of large T antigen (T ag) and small t antigen results in the altered growth phenotypes characteristic of transformation in other species. Human diploid fibroblasts (HF) have a limited lifespan and undergo senescence; T ag results in extension of lifespan but only in rare cases are the cells capable of continuous growth and are immortal. We have developed matched sets of non-immortal and immortal transformed HF for assessment of the steps required for immortalization. Results are summarized to characterize both T-dependent and T-independent functions. A novel growth suppressor gene SEN6 has been identified, the inactivation of which is required for immortalization; it may also serve as a marker to distinguish cells in which SV40 is replicating from those in which it is responsible for tumorigenesis.Developments in biological standardization 02/1998; 94:297-302.
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ABSTRACT: Normal human diploid fibroblasts (HF) have a limited life span, undergo senescence, and rarely, if ever, spontaneously immortalize in culture. Introduction of the gene for T antigen encoded by the DNA virus SV40 extends the life span of HF and increases the frequency of immortalization; however, immortalization requires both T-dependent and T-independent functions. We previously generated independent SV40-transformed non-immortal (pre-immortal) HF cell lines from which we then obtained immortal sublines as part of a multifaceted approach to identify functions responsible for immortalization. In this study we undertook a search for cellular mRNAs which are differentially expressed upon immortalization. A lambda cDNA library was prepared from a pre-immortal SV40-transformed HF (HF-C). We screened the library with a subtracted probe enriched for sequences present in HF-C and reduced in immortal AR5 cells. A more limited screen was also employed for sequences overexpressed in AR5 using a different strategy. Alterations in the level of mRNAs in AR5 encoding functions relevant to signal transduction pathways were identified; however, most cDNAs encoded novel sequences. In an effort to clarify which of the altered mRNAs are most relevant to immortalization, we performed Northern analysis with RNA prepared from three paired sets of independent pre-immortal and immortal (4 cell lines) SV40-transformants using eight cloned cDNAs which show reduced expression in AR5. Three of these were reduced in additional immortal cell lines as well; one, J4-4 (unknown function) is reduced in all the immortal cell lines tested; a second, J4-3 (possible PP2C type phosphatase) is reduced in 2 of the 3 matched sets; and a third, J2-2 (unknown function) is reduced in 2 unrelated immortal cell lines. Although the roles of these genes are as yet unclear, their further analysis should extend our understanding of the molecular bases for immortalization. In particular, the patterns of expression of J4-4 and J4-3 strongly suggest that they are involved in the process of immortalization and/or can serve as target genes for assessing regulators of gene expression in this process.Journal of Cellular Physiology 06/1997; 171(3):325-35. DOI:10.1002/(SICI)1097-4652(199706)171:3<325::AID-JCP11>3.0.CO;2-9 · 3.87 Impact Factor
Article: Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to human chromosome 6p21.1->p12.2 by fluorescence in situ hybridizationCytogenetics and cell genetics 02/1997; 76(1-2):43-4. DOI:10.1159/000134511
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ABSTRACT: Normal cells show a limited lifespan in culture and the phenotype of cellular senescence. Tumors and tumor cell lines have typically overcome this form of growth suppression and grow continuously as immortal cell lines in culture. We have exploited the DNA virus SV40 to study the mechanism by which human fibroblasts overcome senescence and become immortal. Multiple steps have now been identified, including inactivation of cellular growth suppressors through direct interaction with SV40 large T antigen and through mutation of a gene on chromosome 6 (designated SEN6). In this study, we sublocalize the site of SEN6 to 6q26-27 based on molecular genetic analysis. Twelve SV40-immortalized fibroblast cell lines share a deletion in this area based on assessment for loss of heterozygostiy (LOH) for seven informative markers on 6q. Two immortal cell lines (AR5 and HALneo) appeared to have retained separate single copies of chromosome 6 despite the fact that they are both derived from the same preimmortal SV40-transformant and should share the same mutated allele of SEN6 (Hubbard-Smith et al., 1992). Detailed analysis by polymerase chain reaction, restriction fragment length polymorphism and fluorescence in situ hybridization shows, however, that although they differ for 17 markers from the centromere to 6q26, they share AR5 derived sequences (eight markers) distal to 6q26 including the minimal deletion region, further supporting the assignment of SEN6 to this region. Since human tumors including non-Hodgkins lymphoma, mammary carcinoma and ovarian carcinoma show LOH in 6q26-27, inactivation of SEN6 may be responsible for immortalization of these tumors as well.Oncogene 02/1997; 14(3):313-21. DOI:10.1038/sj.onc.1200842 · 8.56 Impact Factor
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ABSTRACT: The ability of SV40 T antigen to block apoptosis was investigated in Rat1-A fibroblasts expressing an estrogen-dependent c-myc construct, mycER (Eilers et al., 1989). These RatmycER cells undergo apoptosis upon activation of c-myc by estradiol under conditions of serum deprivation. Under such conditions SV40-transfected derivatives of RatmycER undergo apoptosis as evidenced by rapid cell death, characteristic morphological changes and DNA fragmentation in a manner indistinguishable from the parental cell line, indicating that T antigen is not able to protect against myc-induced apoptosis. In as much as it had been reported that myc-mediated apoptosis involves wild-type p53 in other systems and T antigen is known to bind and inhibit p53 function, we examined these two polypeptides under different experimental conditions. In all cases, the great majority of the p53 in the SV40 transfectants was found to be in complexes with T antigen. Furthermore, the residual p53 in the uncomplexed state was not sufficient to transactivate an endogenous promoter, WAF1/p21. These data indicate that the failure of T antigen to block apoptosis cannot be attributed to defective function of T antigen and suggest that myc-mediated apoptosis may involve a p53-independent pathway in these cells.Oncogene 06/1996; 12(9):1847-54. · 8.56 Impact Factor
Cytogenetics and cell genetics 02/1996; 73(4):295-6. DOI:10.1159/000134359
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ABSTRACT: We have identified a multistep mechanism by which the DNA virus SV40 overcomes cellular senescence. Expression of SV40 T antigen is required for both transient extension of life span and unlimited life span or immortalization. These effects are mediated through inactivation of function of growth suppressors pRB and p53 via complex formation with T antigen. However, immortalization additionally requires inactivation of a novel growth suppressor gene, which has recently been identified to be on the distal portion of the long arm of chromosome 6, designated SEN6. We propose that SEN6 is responsible for cellular senescence in fibroblasts and other cells.Experimental Gerontology 01/1996; 31(1-2):303-10. DOI:10.1016/0531-5565(95)00024-0 · 3.53 Impact Factor
Clinical Genetics 12/1995; 48(5):275-6. · 3.65 Impact Factor
Article: Alteration of DNA and RNA binding activity of human telomere binding proteins occurs during cellular senescence.[Show abstract] [Hide abstract]
ABSTRACT: The loss of telomere sequences during in vitro and in vivo aging suggests that mechanisms affecting telomere length may have important consequences in cellular senescence. In this study, we have found that the activity of single-stranded telomere binding proteins is increased in nuclear extracts prepared from senescent human diploid fibroblasts compared to actively growing cells. Since single-stranded telomere binding proteins are closely related to RNA binding proteins, we examined the binding activity of several major RNA binding proteins to RNA by uv cross-linking. The level of activity was greatly diminished and the overall pattern of uv cross-linked products were altered in extracts prepared from senescent cells. Furthermore, Western analysis revealed a concurrent decrease in senescent extracts of the protein level for many RNA binding proteins, including those which bind to telomere sequence. Although the reduction in the level of these proteins parallels the reduced activity in RNA binding, the paradoxical increased telomere binding activity exhibited by extracts from older cells suggests a complex relationship between these proteins with RNA and DNA. Moreover, the reduced RNA binding activity of these proteins indicates that the biochemical function of several RNA binding proteins is compromised during cellular senescence, raising an intriguing possibility that a change in pre-mRNA metabolism may contribute to the multitude of changes in gene expression observed in cellular senescence.Experimental Cell Research 06/1995; 218(1):241-7. DOI:10.1006/excr.1995.1152 · 3.37 Impact Factor
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ABSTRACT: Through the advancements of molecular genetics, physicians and researchers are in an extraordinary period of study concerning the molecular basis of medicine. The author discusses recent developments in the identification, isolation, and manipulation of genes.New Jersey medicine: the journal of the Medical Society of New Jersey 12/1994; 91(11):783-6.
Top Journals
Rutgers New Jersey Medical School
Newark, New Jersey, United States
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City University of New York - Hunter College
Manhattan, New York, United States
- Department of Biological Sciences
McGill UniversityMontréal, Quebec, Canada
National Institutes of Health
Maryland, United States
- Chemical Biology Laboratory
National Institute of Allergy and Infectious DiseasesMaryland, United States


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Starkville School District superintendent candidates Walter Gonsoulin and Michael McInnis share a common thread: They each wear many hats in their current position.
The Lowndes County Board of Supervisors voted Tuesday to abandon library construction in Crawford because of a lack of funding. However, supervisors will pursue grant money for a new fire station for the community.
A body discovered on Bud Price Road in Lowndes County has been identified. According to Lowndes County Coroner Greg Merchant, Robert Paul Martindale, 55, of Tishomingo County, was found dead when he was pulled from a boat dock along the Tennessee-Tombigbee Waterway Saturday afternoon.
STARKVILLE -- College students used to spend down time together, either walking, driving or sitting on a campus bench. Long before the days of tracking friends' every movement on Facebook and Twitter, Mississippi State University students had a gathering place known as "the bull ring," a capital D-shaped bench with a shade tree in the middle.
The newest member of the Lowndes County Board of Supervisors is learning, meeting and gaining an appreciation for others who serve in public office. District 2 Supervisor Bill Brigham is new to the board and to public office after spending 40 years in Columbus' banking industry.
STARKVILLE -- Across the country, hundreds of athletes will sign National Letters of Intent today in front of crowds that can't await to watch them play big-time college football. These 17- or 18-year-old student-athletes will be celebrated simply because they will sign a piece of paper.
JACKSON -- The Mississippi Department of Environmental Quality has decided against enforcing proposed amendments to state ground water regulations.
GAINESVILLE, Fla. -- Minutes before two pileups killed 10 people on a highway shrouded in fog and thick smoke from a brush fire, the Florida Highway Patrol had reopened the always busy six-lane interstate after an earlier serious accident.
JACKSON -- The 170-year-old Mississippi Governor's Mansion is undergoing $425,000 in renovations before the new occupants can move in.
JACKSON -- A convicted killer pardoned by former Mississippi Gov. Haley Barbour was in Wyoming with his fiancee and initially drove off when he was located Sunday by investigators seeking to serve him with a court summons, authorities said Monday.
LOWNDES COUNTY -- Two people were hospitalized following a two-vehicle accident just after sunrise Monday morning.
NESHOBA -- Neshoba County Sheriff Tommy Waddell says a Neshoba man and his 4-year-old grandson remain hospitalized after a fire that killed three younger grandchildren, but the dead children's father is out of the hospital.
The first round of interviews for the vacant Starkville superintendent job is in the books. Dr. Lewis Holloway, superintendent of Bulloch County School District (Ga.), and Dr. Michael Van Winkle, assistant superintendent of Jackson County School District, each interviewed Monday for about an hour in executive session at the Starkville School District central office on Greensboro Street.
SOUTHAVEN-- Fourth-term Southaven Mayor Greg Davis said Monday he plans to remain on the job amid continuing state and federal scrutiny of his spending of city money.
GULFPORT -- The $23 million question is whether or not a former high school for African Americans is a historic building.
JACKSON -- More than two-thirds of the Mississippi residents who test positive for the AIDS virus don't get medical treatment, state health officials say.
People who owe the city of Columbus money from uncollected fines will have an opportunity to make their financial amends without going to jail. Beginning Wednesday, a joint effort between the city's municipal court and police department will give citizens amnesty if they voluntarily pay their fines.
The first mission of Columbus Air Force Base is training pilots. Student pilots come from around the world to the hometown base that began as a pilot training post for the U.S. Army Air Corps in 1942 during World War II.
STARKVILLE -- Mississippi State University's football coaching staff is using its 2012 recruiting class to define a philosophy.
A downtown Columbus bar steeped in controversy opened its doors Friday afternoon after being closed for almost a year. The Elbow Room at 418 Second Ave. N. was the scene of a double homicide in 2011.
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1. Browning on Business: Sno-cone business coming back BUSINESS
2. Photo: Hwy. 45 wreck COLUMBUS & LOWNDES COUNTY
3. Students accused of statutory rape COLUMBUS & LOWNDES COUNTY
4. Railroad co. investigating derailment in Columbus COLUMBUS & LOWNDES COUNTY
5. Man arrested after close call with school bus STARKVILLE & OKTIBBEHA COUNTY


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Venice Island Pool Home
324 Parkdale Dr, Venice, FL 34285
|Per week:
|$1,200 - $1,400
|Per month:
|$3,500 - $4,000
|Pets allowed:
Description of the Venice vacation home rental
Very spacious and beautifully furnished pool home. Three bedrooms and two bathrooms. Fully furnished, shuffleboard and horseshoe pit in back yard, outside speakers by the pool,24 hour recorded outdoor surveillance, too much to list. More pictures available upon request. Meticulously maintained, spotless inside and out. Large yard, walking distance to Venice shops, restaurants, Venice Little Theater, public tennis, basketball courts, parks, Walk to beach (7/10 of a mile- 10 minute walk). Very nice location. $1400.00 a week (may 1 through October 31) plus cleaning fee and FL tax, you will not find a better deal for this price. Wireless internet . Price for November through April is $4000.00 per month.January, February and March 2015 are already reserved. Reserve now for 2015 winter, it will go fast. Christmas and New Years Weeks are $1600.00 per week. Contact Bill- Four Zero One, four one three, eight two one two. Sorry, No Pets, No animals and No Smoking.
Area Information
Lovely quiet area. Walking distance to beach(7/10 of a mile), walk to shops, restaurants, Venice Little Theater (great plays). Click on area map link, zoom in and you will see how close the beach is, just walk straight down the street, take a right at the end and you're at the beach.
Availability Calendar
|Nov 01 2014
|Apr 30 2015
|1 Week
|May 01 2015
|Oct 31 2015
|1 Week
|Check In: 4 p.m. Check Out: 11 a.m.
|Lodging tax: 12%
|Deposits: Fifty percent of rental deposit required to reserve for winter rental.Remainder to be paid 60 days prior to arrival.
|Payment Options: Cashier's Check, Money Order
|Other Fees: One hundred fifty dollar end of stay cleaning fee. Five Hundred dollar security deposit, refunded within 30 days of departure.
- 2 King Beds
- 1 Queen Bed
- Air Conditioning
- Bikes
- High Speed Internet
- Parking Included
- Beach Chairs
- Full Kitchen
- Lanai
- Private Pool
- Beach Towels
- Garage
- Linens Provided
- Screened Porch
- Alarm Clock
- DVD Player
- Iron
- Stereo
- Blender
- Dishwasher
- Microwave
- Stove
- CD Player
- Gas Grill
- Oven
- TV (Cable/Satellite)
- Ceiling Fan
- Hair Dryer
- Radio
- Toaster
- Coffee Maker
- Ice Maker
- Refrigerator (Full)
- Washer/Dryer
- Pool
- Children's Pool
(<1 mile)
- Playground
(<1 mile)
- Tennis
(<1 mile)
- Basketball Court
(<1 mile)
- Jet Skiing
(<1 mile)
- Restaurant
(<1 mile)
- Water Skiing
(<1 mile)
- Beach
(<1 mile)
- Live Entertainment
(<1 mile)
- Sailing
(<1 mile)
- Bowling
(2 miles)
- Bicycling
(<1 mile)
- Ocean
(<1 mile)
- Shopping Area
(<1 mile)
- Grocery Store
(2 miles)
- Boating
(<1 mile)
- Park
(<1 mile)
- Surfing
(<1 mile)
- Movie Theater
(5 miles)
- Canoeing
(<1 mile)
Other Vacation Rental Amenities
Plenty to do for kids and adults. There is a kiddie water fountain for the kids to play in two blocks away, shops and restaurants are only a couple blocks away or just stay home and play shuffleboard or horse shoes in the back yard, sit by the pool and listen to music or read a book. Venice is a spectacular area. If you have never been there, you must see it. Go to the jetty down by the beach and watch the dolphins jump out of the water as you watch the sun set every evening, then go to Crow's Nest for a drink or a bite to eat. Call me anytime for suggestions, directions or any questions at all. Call Bill- four zero one, four one three, eight two one two.
Reviews for this vacation home rental in Venice, Florida
Have you been a guest of this property? Write a review!
Sandra McKinney
Middle Georgia
Excellent Accommodation
July 28, 2012
This was a wonderful place for a vacation in Venice. The house was large enough to accommodate 5 people very comfortably. It was the attention to detail that made our stay so pleasant. It was fully stocked from providing beach towels, to detergent, to beach chairs, to bottled water, etc. The pool as well as the house was very clean and the entire environment was very nice and inviting. The owner was very helpful and accessible. We certainly would want to stay there again if we travel back to Venice.
Interested in Renting this Property?
Page Views This month: 107 This year: 340 Since listed: 12,003
Last updated: March 23, 2015
Contact Owner
Owner Profile
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School:Diman Region Voc / Tech High
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Learn more about Nfl Super Bowl Collection Xxi-Xxx 5pk:
Format: DVD
Manufacturer: Warner
Sku: 40251733
Category Keywords: Sports Heroes/Legends/Inspirations
See more in Gift Sets/Limited Edition/Collectible
|Live the excitement of the third 10 Super Bowls and the seasons leading up to each big game in a five-disc collector's set loaded with defining highlights, enhanced content and exclusive memorabilia.
Editor's NoteWith action from 10 Super Bowls contained on this release, the breathless wonder of the sport is brought to life through an awesome collection of highlights. The action begins with the 21st Super Bowl, and includes everything up to the 30th, with the cameras getting up close to the action, and delivering a thrilling selection of plays from the games. With plenty of memorabilia, interview footage, and other delights also included, this is a comprehensive package for sports fans everywhere.


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Water Heater Vent in Laundry Room. HELP!
We have a small laundry room maybe 6x4 that leads to the garage. The builder originally put the water heater in the room which was an eyesore, left no room for cabinets, and worried me it would burst and flood my house someday. Last year we removed it and put a tankless under the house. Now we are ready to install cabinets but there is a vent to the attic in the ceiling that I would like to remove and drywall over so we have cabinets to the ceiling. We've asked several plumbers and have gotten several answers if we need this vent now the water heater is gone. We have an electric washer and dryer. There is an A/C vent in there too which sometimes gets condensation on it when it is very hot and humid outside (vent is immediately in front of door that has a doggie door leading to garage). Are we ok to remove the old water heater vent or do we need it because of moisture in the air? The condensation that appears on the A/C vent gives me pause to just cover up the other vent. One person suggested covering the old vent and installing a fan like they do in bathrooms but I really don't want that. My other option is to leave the vent and start the cabinets 6" from the ceiling. HELP! Any ideas? THANKS!!


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1960s, Literature, Magazine, Youth Culture •
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From 1950 through to '68 an imprint of DC Comics (National Periodical Publications in case you were wondering) published 'The Adventures of Bob Hope'. A comic book equivalent to the assorted shows that Bob Hope was involved in during the period. It ran...
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1970s, Art, Magazine, Music, Youth Culture •
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You've heard the album, listened to the song, seen the film, and got the T shirt or perhaps you were there (man) at the most famous rock festival in history, but now it's time to take a look at Woodstock – The comics. Here we have not one,...
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1970s, Music, Television, Youth Culture •
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Back to a time before the Rolling Stones had wrinkles, before Keith Richards started looking like a pirate and a Canadian documentary featuring lots of drugs, lots of police, lots of vinyl and almost inevitably lots of hair. This fascinating piece of social...
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1960s, Documentary, Film, Youth Culture •
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They Call Us Misfits or They Call Us Mods ( Dom kallar oss mods) is a 1968 Swedish documentary that was directed, produced and written by Stefan Jarl and Jan Lindqvist. This video is their first film in the Mods Trilogy series, the second film A Decent life...
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1960s, Documentary, Youth Culture •
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Evolutionary biologists have long been fascinated with the development of species on the Australian sub-continent and the way they have evolved without the effect of any external influences to create such unique creatures as kangaroos, wallabies and koala...
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