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Publications (116)647.12 Total impact
Article: Coronary and aortic calcifications interrelationship in stable angina pectoris patients as detected by spiral CTAtherosclerosis Supplements 06/2007; 8(1):135-135. DOI:10.1016/S1567-5688(07)71493-9 · 9.67 Impact Factor
Article: Clinical evidence of dose-dependent interaction between aspirin and angiotensin-converting enzyme inhibitors.[Show abstract] [Hide abstract]
ABSTRACT: Since coronary artery and cerebrovascular diseases are the most common serious complications of long standing hypertension, there is a great potential for combining treatment with aspirin and angiotensin-converting enzyme inhibitors (ACE-I). However, the data regarding interaction of aspirin and ACE-I in relation to blood pressure control and survival benefits are controversial and inconclusive. We presumed that the appearance of dry cough in some of the patients following initiation of ACE-I treatment could be used as a marker for the presence of their influence, whereas ACE-I cough attenuation after addition of aspirin to treatment could be a sign of aspirin and ACE-I interaction on clinical level. The present study was aimed to use ACE-I induced cough as a clinical marker of ACE-I activity to determine whether dose-dependent aspirin and ACE-I interaction does exist. In a cohort of 750 consecutive ACE-I treated hypertensive and postinfarction outpatients we identified 78 (10.4%) non-smoking ACE-I related coughers. Out of them, 31 (21 men, 10 women; mean age 61 +/- 0.9 years) agreed to take part in the study, which was aimed to compare two regimens of combined ACE-I and aspirin treatment (self-matched control data): intermediate (500 mg daily) vs low-dose aspirin (100 mg daily). On each visit the life quality, cough severity (CS, 0-4) and frequency (CF, 0-10) scores were registered. Low doses of aspirin demonstrated an excellent safety profile and did not influence any life quality score and ACE-I induced cough. In contrast, intermediate doses completely abolished cough in 17 patients and reduced coughing in other 11 patients. Cough severity and cough frequency scores decreased, respectively, from 2.7 +/- 1.1 to 0.7 +/- 1.2 (P < 0.001) and from 7.1 +/- 2.3 to 2.0 +/- 2.2 (P < 0.0001). Overall, the cough frequency score method alone could identify a clear modification of cough in 26 (84%) patients, and cough severity score method alone in 24 (77%). Using the combined frequency/severity score method a modification of cough could be identified in 28 (90%) of the patients receiving intermediate dose of aspirin. Aspirin did not influence heart rate and blood pressure control either in hypertensives or in postinfarction patients. We conclude that using ACE-I induced cough as a clinical marker of ACE-I activity demonstrates that an interaction between ACE-I and aspirin at 500 mg/day does exist. We did not find any evidence supporting the presence of a clinically significant interaction between ACE-I and aspirin at 100 mg/day. Thus, combined treatment by low dose aspirin and ACE-I seems to be both safe and useful.Journal of Human Hypertension 07/2002; 16(6):379-83. DOI:10.1038/sj.jhh.1001406 · 2.69 Impact Factor
Article: Retrograde embolism and atherosclerosis development in the human thoracic aorta: are the fluid dynamics explanations valid?[Show abstract] [Hide abstract]
ABSTRACT: The mechanisms of atherosclerosis development in the thoracic aorta is miscellaneous and still only partially understood. The marked variability of the sites of deposition of atherosclerotic plaques in the aorta could not be clarified based solely on the risk-factors theory of atherosclerosis. The sites of deposition of atherosclerotic plaques are considered to be affected by blood-flow patterns that cause areas of altered shear stress on the aortic wall. Close relations between protruding aortic plaques (PAP), stroke and peripheral emboli were established. The analysis of PAP distribution and motion to characterize atherogenesis in the human thoracic aorta and the pathogeneses of embolic events was performed. We concluded that protruding aortic plaques and markers of relative aortic flow instability (occurrences of vortices) are predominantly noticed in the human arch and in the descending aorta, whereas the ascending aorta showed lesser prevalence of atheromatosis. Reversal and rotational blood-flow in the thoracic aorta most likely exist in all patients with systemic emboli and mobile protruding aortic atheromas. Therefore, retrograde cerebral embolism from distal aortic plaques is conceivable.Medical Hypotheses 12/2001; 57(5):642-7. DOI:10.1054/mehy.2001.1433 · 1.15 Impact Factor
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ABSTRACT: Calcium antagonists effective in lowering blood pressure are a heterogeneous group including three main classes: phenylalkylamines, benzothiazepines and dihydropyridines. Dihydropyridines have a dual mode of action upon the endothelium contributing to their beneficial antihypertensive effects: (1) direct relaxation by inhibition of smooth muscle L-type calcium current, and (2) indirect relaxation through release of nitric oxide from the vascular endothelium. Calcium antagonists may affect many calcium-dependent events in the formation of atherosclerosis such as the localized accumulation of collagen, elastin, and calcium together with monocyte infiltration and smooth muscle proliferation and migration. In the INSIGHT calcification study, the overall treatment effect of nifedipine demonstrated significant inhibition of coronary calcium progression over a three-year period. Calcium antagonists improve symptoms and reduce ischemia in hypertensive patients with ischemic heart disease. Although in placebo-controlled trials calcium antagonists demonstrated a significant reduction in cardiovascular morbidity and mortality, they may be less effective than other types of antihypertensive drugs in preventing ischemic heart disease.Current Opinion in Cardiology 12/2001; 16(6):349-55. DOI:10.1097/00001573-200111000-00006 · 2.59 Impact Factor
Article: Intensive isotonic training modifies basal and exercise Doppler indexes of systolic function: a comparative study of athletes and sedentary men.The American Journal of Cardiology 10/2001; 88(5):594-8. DOI:10.1016/S0002-9149(01)01752-0 · 3.43 Impact Factor
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ABSTRACT: Mitral annular calcification is a common echocardiographic finding. Caseous calcification is a rare variant seen as a large mass with echolucencies that resembles a tumor, occasionally resulting in exploratory cardiotomy. The aim of this study was to assess the prevalence of caseous calcification of the mitral annulus, to evaluate patient characteristics and the echocardiographic variables for diagnosing this entity, and to describe the clinical outcome on follow-up of such patients. Caseous calcification was defined as a large, round, echo-dense mass with smooth borders situated in the periannular region, with no acoustic shadowing artifacts and containing central areas of echolucencies resembling liquefaction. Eighteen patients were diagnosed by 2-dimensional echocardiography as having caseous calcification of the mitral annulus. One had calcification of the tricuspid annulus. Nine patients underwent transesophageal echocardiographic studies. A typical finding of a round, sometimes semilunar, large, echo-dense, soft mass with central echolucencies seen on both transthoracic and in particular transesophageal echocardiography, resembling a periannular mass, was demonstrated. The mass was posteriorly located in all mitral patients. Transesophageal echocardiography added limited information. Three patients underwent mitral valve replacement. The operative findings were a solid mass adherent to the posterior portion of the mitral valve. Sectioning revealed a toothpaste-like, white, caseous material. Sixteen (84%) patients were treated conservatively. On follow-up of 3.8 +/- 2.4 years, 4 patients died of unrelated causes. The characteristic appearance of a large, soft, echo-dense mass containing central areas of echolucencies resembling liquefaction at the posterior periannular region of the mitral valve on 2D echocardiography is compatible with the diagnosis of caseous abscess. Such a finding should not be confused with a tumor. Transesophageal echocardiography does not appear to contribute to the diagnosis. This rather impressive lesion appears to carry a benign prognosis.Journal of the American Society of Echocardiography 09/2001; 14(8):825-31. DOI:10.1067/mje.2001.111877 · 3.99 Impact Factor
Article: Long-term diuretic therapy in patients with coronary disease: increased colon cancer-related mortality over a 5-year follow-up[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have suggested that long-term diuretic therapy may be associated with increased risk of renal cell carcinoma. This carcinoma is not a common malignancy, but it shares risk factors with the considerably more widespread colon cancer (CC). However, there are no data whether or not a relationship between long-term diuretic therapy and CC mortality exists. In this study we tested the hypothesis that long-term diuretic therapy may be associated with increased CC mortality over a 5.6-year follow-up period. The study sample comprised 14 166 patients aged 45 to 74 years with a previous myocardial infarction and/or stable anginal syndrome, screened for participation in the bezafibrate infarction prevention (BIP) study. There were 2153 patients receiving diuretics and 12 013 patients receiving no diuretics. During the follow-up 139 (6.5%) new cases of cancer were diagnosed in the diuretic-treated group compared with 622 (5.2%) in the group receiving no diuretics (P = 0.02). Colon cancer mortality was significantly higher in the diuretic-treated patients (0.1 vs 0.5%, P = 0.001), whereas mortality differences for other cancer types were not documented. Multivariate analysis identified diuretics as an independent predictor of increased colon cancer incidence and colon cancer mortality with a hazard ratio (HR) of 2.0 (95% CI 1.2-3.2) for colon cancer incidence and 3.7 (95% CI 1.7-8.3) for mortality. However, the association between diuretic therapy and higher incidence of colon cancer was observed only among non-users of aspirin. A relatively lower colon cancer incidence was observed in the furosemide subgroup, and higher in the small combined amiloride/hydrochlorthiazide subgroup (HR 3.15, 95% CI 1.15-8.65). Long-term exposure to diuretic therapy may be associated with an increased colon cancer-related mortality.Journal of Human Hypertension 07/2001; 15(6):373-9. DOI:10.1038/sj.jhh.1001192 · 2.69 Impact Factor
Article: Annual progression of coronary artery calcium by spiral computed tomography in hypertensive patients without myocardial ischemia but with prominent atherosclerotic risk factors, in patients with previous angina pectoris or healed acute myocardial infarction, and in patients with coronary events during follow-upThe American Journal of Cardiology 07/2001; 87(12):1395-7. DOI:10.1016/S0002-9149(01)01561-2 · 3.43 Impact Factor
Article: Impaired fasting glucose concentrations in nondiabetic patients with ischemic heart disease: a marker for a worse prognosis.[Show abstract] [Hide abstract]
ABSTRACT: The issue of whether glucose concentrations below the diabetic threshold may be predictive of increased cardiovascular risk has not yet been fully elucidated. The current study evaluates the prognosis of nondiabetic patients with ischemic heart disease (IHD) and impaired fasting glucose (IFG) over a 7.7-year follow-up period. A total of 11,853 patients with documented coronary artery disease aged between 45 and 74 years were examined. Patients were divided into 3 groups on the basis of their fasting blood glucose levels at screening: nondiabetic individuals, patients with IFG, and undiagnosed diabetic patients. Patients who were on any type of pharmacologic antidiabetic treatment were excluded from the study. Mortality rates were assessed separately for each group. The population comprised 9773 nondiabetic patients (82.4%, glucose up to 109 mg/dL), 1258 patients with IFG levels (10.6%, glucose 110-125 mg/dL), and 822 diabetic subjects (7%, glucose > or =126 mg/dL). Patients were followed up from 6.2 to 9.0 years (mean follow-up period 7.7 +/- 1.5 years). Crude mortality was lower in the nondiabetic subjects than in the 2 other groups. All-cause mortality in the nondiabetic group was 14.3% compared to 20.1% in patients with IFG and 24.3% in the undiagnosed (P <.001). Multivariate adjustment showed the lowest mortality in nondiabetic subjects, who exhibited a survival rate of 0.86 at the end of the follow-up, whereas the lowest survival-0.75-was seen among undiagnosed diabetic patients (P =.0001). An intermediate value of 0.78 was documented for patients with IFG (P <.01). After multivariate analysis, with nondiabetic patients as the reference group, IFG was identified as a consistent predictor of increased all-cause and IHD mortality with hazard ratios of 1.39 (95% confidence interval 1.21-1.59) and 1.29 (95% confidence interval 1.01-1.64), respectively. The main finding of this study is the substantially increased mortality rate among nondiabetic coronary patients with IFG, who had fasting glucose levels markedly lower than hitherto acknowledged as defining overt diabetes.American Heart Journal 04/2001; 141(3):485-90. DOI:10.1067/mhj.2001.113219 · 4.56 Impact Factor
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ABSTRACT: The significance of antioxidized low-density lipoprotein (oxLDL) antibodies in atherogenesis is not yet clear, and there are conflicting data regarding anti-oxLDL levels in early hypertension. The levels of anti-oxLDL antibodies were studied in coronary artery disease patients with (n = 82) or without (n = 36) hypertension, in association to other risk factors for coronary artery disease. The levels of anti-oxLDL antibodies did not differ significantly between coronary artery disease patients with or without hypertension. (0.132 +/- 0.146 v 0.153 +/- 0.158 optical density at 405 nm, respectively; P = .48). No significant differences in anti-oxLDL antibodies were found between men and women with and without hypertension, between hypertensive patients with normal and abnormal blood pressure measurements, and between medicated and nonmedicated hypertensive patients. The presence of diabetes mellitus, smoking, and hypercholesterolemia, either solely or in combination, did not result in significant differences in antibody levels in the hypertensive or normotensive patients. Although the levels of oxLDL antibodies might be modified in early hypertension, once advanced coronary artery disease has developed the presence of hypertension does not affect anti-oxLDL levels.American Journal of Hypertension 03/2001; 14(2):149-54. DOI:10.1016/S0895-7061(00)01242-5 · 3.40 Impact Factor
The American Journal of Medicine 03/2001; 110(2):143-5. DOI:10.1016/S0002-9343(00)00674-4 · 5.30 Impact Factor
Article: Usefulness of spiral computed tomography (dual-slice mode) for the detection of coronary artery calcium in patients with chronic atypical chest pain, in typical angina pectoris, and in asymptomatic subjects with prominent atherosclerotic risk factors.[Show abstract] [Hide abstract]
ABSTRACT: The prevalence and extent of coronary calcium were retrospectively assessed by spiral computed tomography in 541 patients (mean age 62 +/- 9 years), of whom 101 had typical angina pectoris, 307 had atypical chest pain, and 133 were asymptomatic subjects with prominent atherosclerotic risk factors. The highest prevalence of coronary calcium was in men with angina pectoris (89%), whereas it was not detected in 48% of men and 56% of women with atypical chest pain.The American Journal of Cardiology 02/2001; 87(2):226-8, A9. DOI:10.1016/S0002-9149(00)01325-4 · 3.43 Impact Factor
Article: Oral antidiabetic treatment in patients with coronary disease: Time-related increased mortality on combined glyburide/metformin therapy over a 7.7-year follow-up[Show abstract] [Hide abstract]
ABSTRACT: A sulfonylurea--usually glyburide--plus metformin constitute the most widely used oral antihyperglycemic combination in clinical practice. Both medications present undesirable cardiovascular effects. The issue whether the adverse effects of each of these pharmacologic agents may be additive and detrimental to the prognosis for coronary patients has not yet been specifically addressed. This study was designed to examine the survival in type 2 diabetics with proven coronary artery disease (CAD) receiving a combined glyburide/metformin antihyperglycemic treatment over a long-term follow-up period. The study sample comprised 2,275 diabetic patients, aged 45-74 years, with proven CAD, who were screened but not included in the bezafibrate infarction prevention study. In addition, 9,047 nondiabetic patients with CAD represented a reference group. Diabetics were divided into four groups on the basis of their therapeutic regimen: diet alone (n = 990), glyburide (n = 953), metformin (n = 79), and a combination of the latter two (n = 253). The diabetic groups presented similar clinical characteristics upon recruitment. Crude mortality rate after a 7.7-year follow-up was lower in nondiabetics (14 vs. 31.6%, p<0.001). Among diabetics, 720 patients died: 260 on diet (mortality 26.3%), 324 on glyburide (34%), 25 on metformin alone (31.6%), and 111 patients (43.9%) on combined treatment (p<0.000001). Time-related mortality was almost equal for patients on metformin and on combined therapy over an intermediate follow-up period of 4 years (survival rates 0.80 and 0.79, respectively). The group on combined treatment presented the worst prognosis over the long-term follow-up, with a time-related survival rate of 0.59 after 7 years, versus 0.68 and 0.70 for glyburide and metformin, respectively. After adjustment to variables for prognosis, the use of the combined treatment was associated with an increased hazard ratio (HR) for all-cause mortality of 1.53 (95% confidence interval [CI] 1.20-1.96), whereas glyburide and metformin alone yielded HR 1.22 (95% CI 1.02-1.45) and HR 1.26 (95% CI 0.81-1.96), respectively. Conclusions: We conclude that after a 7.7-year follow-up, monotherapy with either glyburide or metformin in diabetic patients with CAD yielded a similar outcome and was associated with a modest increase in mortality. However, time-related mortality was markedly increased when a combined glyburide/metformin treatment was used.Clinical Cardiology 02/2001; 24(2):151-8. DOI:10.1002/clc.4960240210 · 2.23 Impact Factor
Article: Coronary artery disease but not coronary calcification is associated with elevated levels of cardiolipin, beta-2-glycoprotein-I, and oxidized LDL antibodies.[Show abstract] [Hide abstract]
ABSTRACT: Autoimmune factors have been shown to play a role in atherosclerosis. The aim of this study is to correlate 5 autoantibodies (anticardiolipin, anti-CL, beta2-glycoprotein-I, beta2GPI, phosphatidylcholine, oxidized low-density lipoprotein, oxLDL, endothelial cell) with the presence of coronary heart disease, angiographic findings, and with coronary artery calcification. The levels of the 5 autoantibodies and a control antifibroblast line of 126 coronary heart disease patients and 20 healthy controls were measured. Fifty-one patients underwent coronary angiography, and 98 patients had coronary artery calcium determination using spiral computerized tomography (dual mode). Levels of 3 autoantibodies (anti-CL, beta2GPI, oxLDL) were significantly elevated in coronary heart disease patients compared with controls (p < 0.001, p = 0.001, p < 0.001, respectively). Within the subgroup of patients with significant coronary artery stenosis, anti-CL antibodies were also elevated (p = 0.008). No correlation was found between anti-CL, and anti-beta2GPI autoantibody levels and coronary calcium scores as measured by spiral computerized tomography. However, anti-oxLDL antibodies were raised in patients with no calcification detected by spiral computerized tomography, compared with the patients with any coronary calcification (p = 0.046). Anti-CL, beta2GPI and oxLDL antibodies are elevated in coronary heart disease patients regardless of coronary calcification.Cardiology 01/2001; 95(1):20-4. · 2.04 Impact Factor
Article: The combined cough frequency/severity scoring: a new approach to cough evaluation in clinical settings.[Show abstract] [Hide abstract]
ABSTRACT: Cough assessment is an important component in the clinical evaluation of patients with respiratory and cardiovascular disorders (asthma, chronic obstructive lung disease, congestive heart failure, etc.). A dry bothersome cough is the most common adverse class effect of all angiotensin-converting enzyme inhibitors (ACE-I). The present study was aimed to determine the feasibility of a new combined frequency/severity cough scoring method in patients with ACE-I induced cough before and after their modification with aspirin addition. The study was designed to compare two different regimens of active treatment: intermediate (500 mg) versus low (100 mg) dose aspirin in ACE-I cough suppression (self-matched control data) and comprised 21 patients (14 men, 7 women; mean age 62 +/- 11 years) on ACE-I treatment. ACE-I treatment was discontinued and the dry cough completely disappeared, but returned in all patients within one week (rechallenge period) after ACE-I reintroducing. Severity of cough was defined as follows: 0--no cough at all; 1--occasional hems; 2--mild, isolated cough, without additional symptoms; 3--moderate, paroxysmal cough, without additional symptoms; 4--severe, strenuous cough, accompanied by chest discomfort. In addition to cough severity score, cough frequency score (0-10) was obtained using a visual analog scale: 0 = I never cough; 10 = I cough all day. Low doses of aspirin were ineffective to suppress ACE-I induced cough. In contrast, intermediate doses completely abolished cough in 14 patients and reduced coughing in all but one patient. Cough severity and cough frequency scores decreased, respectively, from 2.6 +/- 1.1 to 0.7 +/- 1.0 (p<0.001) and from 6.9 +/- 2.2 to 2.1 +/- 2.4 (p<0.0001). Overall, the cough frequency score method alone could identify a beneficial modification of cough in 17 (81%) patients and cough severity score method alone in 17 (76%). Using the combined cough frequency/severity scoring, a beneficial modification of cough could be identified in 20 (95%) of patients. The new combined cough frequency/severity scoring is suitable for clinical practice and can improve the identification of dynamic cough modifications during treatment period as compared with the conventional frequency score method. It may have important implications in the evaluation of patients with respiratory and cardiovascular disorders.Journal of medicine 01/2001; 32(3-4):181-7.
Article: Clinical impact of borderline and undiagnosed diabetes mellitus in patients with coronary artery disease[Show abstract] [Hide abstract]
ABSTRACT: The present study was aimed to evaluate the prevalence and prognostic significance of unrecognized and newly defined borderline diabetes (with fasting blood sugar 126 to 139 mg/dl) by the American Diabetes Association criteria in coronary patients over a 7.7-year follow-up. Both undiagnosed and newly diagnosed borderline diabetes were associated with an unfavorable metabolic profile. The mortality of the borderline diabetics tended to be higher than in their nondiabetic counterparts. but this tendency did not reach statistical significance. A significant excess in long-term mortality was observed among the undiagnosed diabetes group.The American Journal of Cardiology 01/2001; 86(12):1363-6, A4-5. DOI:10.1016/S0002-9149(00)01244-3 · 3.43 Impact Factor
Article: Retrograde flow in the thoracic aorta in patients with systemic emboli - A transesophageal echocardiographic evaluation of mobile plaque motion[Show abstract] [Hide abstract]
ABSTRACT: Blood flow in the aorta is complex and incompletely characterized. Mobile aortic plaques (MAPs), moving freely with the pulsatile aortic flow, in fact represent natural tracers that reflect the flow pattern itself. Our aim was to use MAP motion on transesophageal echocardiography (TEE) in order to characterize flow patterns in the atheromatous thoracic aorta of patients with systemic emboli. The study group was recruited from 250 patients referred for TEE to evaluate recent embolism. Among them, 22 patients (14 men and 8 women; mean +/- SD age, 66.3 +/- 7.2 years; 16 patients with cerebrovascular and 6 patients with peripheral emboli) with MAPs of > or = 3 mm in length formed the study group. The longest amplitudes of three spatial components of mobile lesion motions were measured: x (antegrade/retrograde [A/R]), y (up/down [U/D], and z (right/left [R/L]). A total of 33 mobile lesions were detected: 3 in the ascending aorta (1 patient), 13 in the arch (10 patients), and 17 in the descending aorta (11 patients). The length of mobile plaque components ranged from 3 to 13 mm; amplitudes of A/R, U/d, R/L, and retrograde flow motions ranged from 3 to 26 mm, from 1 to 16 mm, from 1 to 17 mm, and from 1 to 13 mm, respectively. Systolic rotational motion was clockwise in six patients (27%), counterclockwise in five patients (23%), incomplete (semicircle) in six patients (27%), and alternate clockwise/counterclockwise in five patients (23%). Diastolic rotational motion was clockwise in 5 patients (23%), counterclockwise in 6 patients (27%), and incomplete (semicircle) in 11 patients (50%). There were 18 multiple MAPs in seven patients: in all these cases, simultaneous rotations of MAP in different directions (as a marker for the presence of multiple vortices) were found. In nine patients with cerebral embolism, MAPs on the distal part of aortic arch solely were found; in five of them, all alternative potential sources of stroke were excluded. Therefore, retrograde cerebral embolism from distal aortic plaques in these patients is highly probable. Retrograde and rotational blood flow in the thoracic aorta probably exists in all patients with systemic emboli and mobile protruding aortic atheromas. Therefore, retrograde cerebral embolism from distal aortic plaques is theoretically possible.Chest 12/2000; 118(6):1703-8. DOI:10.1378/chest.118.6.1703 · 7.13 Impact Factor
Article: Blunted responses of Doppler-derived aortic flow parameters during whole-body heavy isometric exercise in heart transplant recipients[Show abstract] [Hide abstract]
ABSTRACT: Relatively light isometric exercise (handgrip) in heart transplant recipients induces attenuated increments in heart rate, blood pressure, and systemic vascular resistance, but hemodynamic response to whole-body, heavy isometric exercise is unknown. The aim of our study was to investigate the influences of whole-body, heavy, isometric exercise on Doppler-derived parameters in these patients. We investigated 18 patients, aged 54.0 +/- 2 years, 1.6 +/- 1.0 years after cardiac transplantation and 18 sedentary healthy volunteers, aged 51.8 +/- 4 years (p = not significant). Patients performed supine, isometric exercise by stretching a whole-body isometric device at 50% of maximal voluntary contraction for 3 minutes. Resting heart rate, blood pressure, and rate-pressure product were higher in transplanted patients when compared with the healthy volunteers (p < 0.001 for all). However, during isometric exercise, these parameters increased to a lesser extent in the transplanted compared with the healthy subjects-heart rate, 12% vs 40% (p < 0.001); mean arterial pressure, 20% vs 27% (p < 0.05); and rate-pressure product, 39% vs 85% (p < 0.001). In the healthy volunteers, peak-flow velocity, mean acceleration, flow-velocity integral, and stroke volume decreased by 30% to 40% with isometric exercise (p < 0.001 for all), whereas systemic vascular resistance increased by 36% (p < 0.001) and cardiac output did not change. In the transplanted patients, all above parameters remained unchanged. Heavy, whole-body isometric exercise was well tolerated in heart transplant recipients in this study, without hemodynamic deterioration or other complications. With whole-body, heavy isometric exercise, Doppler-derived aortic flow parameters demonstrate blunted responses or remain unchanged among heart transplant recipients. The observed phenomenon may have implications for studies of exercise physiology in transplant recipients.The Journal of Heart and Lung Transplantation 11/2000; 19(11):1063-70. DOI:10.1016/S1053-2498(00)00204-7 · 5.61 Impact Factor
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ABSTRACT: To investigate the accuracy of dual-section spiral computed tomography (CT) in tracking the progression of coronary calcification, as measured during a 3-year follow-up. Two hundred forty-six patients with hypertension (mean age, 66 years +/- 6 [SD]) were preselected in accordance with the International Nifedipine Study Intervention as a Goal for Hypertension Therapy protocol. Subjects had no clinical coronary arterial disease prior to the study and no cardiovascular events during follow-up. All participants underwent baseline CT (3.2-mm section thickness; reconstruction increment, 1.5 mm) and follow-up CT after 3 years. Calcification progression was defined as any increase in total calcification score (TCS) and analyzed in accordance with five baseline TCS categories: 1-9, 10-35, 36-100, 101-250, and greater than 250. At baseline CT, 152 patients had a TCS greater than 0, and 106 (70%) showed progression after 3 years, while 94 had a baseline TCS of 0; of these, 26 (28%) showed progression (P: <.01 between groups). The mean TCS was significantly higher in each baseline TCS category after 3 years. The percentage increase was negatively correlated with baseline TCS (P: <.01) and ranged from 466% in the lowest category to 38% in the highest. Dual-section spiral CT depicts significant change in TCS over time and is useful in tracking calcified coronary atherosclerosis.Radiology 11/2000; 217(2):461-5. DOI:10.1148/radiology.217.2.r00nv25461 · 6.21 Impact Factor
Article: Intermediate but not low doses of aspirin can suppress angiotensin-converting enzyme inhibitor-induced cough.[Show abstract] [Hide abstract]
ABSTRACT: This self-matched control study aimed to compare the efficiency of two different regimens of active treatment: aspirin in low (100 mg daily) versus intermediate (500 mg daily) doses in abolishing angiotensin-converting enzyme inhibitor (ACEI)-induced cough. A dry bothersome cough is the most common adverse class effect of all angiotensin-converting enzyme inhibitors. Prostaglandins (PG) have been pinpointed as playing a leading role in the genesis of ACEI-associated cough. The role of different doses of the most commonly used PG inhibitor-aspirin-in ACEI cough modification was not yet elucidated. Of 350 consecutive ACEI-treated patients, we identified 34 (9.7%) nonsmoking ACEI-related coughers. Patients with lung disease, nonsteroidal anti-inflammatory drug (NSAID) treatment, and those who did not agree to participate in the study were excluded. In the remaining 14 ACEI coughers (eight men, six women; mean age, 63 +/- 11 years), the treatment was discontinued; the dry cough completely disappeared, but returned in all patients within 1 week after ACEI reintroduction. At the end of the rechallenge period, patients started a low dose of aspirin for 1 week, switching thereafter to the intermediate dose of aspirin for an additional week. On each visit the cough severity (CS, 0-4) and frequency (CF, 0-10) scores were registered. Low doses of aspirin were ineffective in suppressing ACEI-induced cough, whereas intermediate doses completely abolished cough in five patients and reduced coughing in all but one patient; CS and CF decreased, respectively, from 2.5 +/- 1.0 to 0.9 +/- 1.1, P < .002 and from 6.6 +/- 2.4 to 2.4 +/- 1.1, P < .0002. Overall, intermediate doses of aspirin beneficially modified cough scores in 13 (93%) patients, enabling nine (64%) to continue ACEI treatment. Aspirin did not influence blood pressure control either in hypertensives or in postinfarction patients. We conclude that intermediate but not low doses of aspirin probably can suppress ACEI-induced cough. These findings propose a new alternative therapeutic approach for patients with ACEI-related cough, especially those in whom ACEI treatment seems to be essential.American Journal of Hypertension 07/2000; 13(7):776-82. DOI:10.1016/S0895-7061(00)00268-5 · 3.40 Impact Factor
Top Journals
- The American Journal of Cardiology (18)
- American Heart Journal (15)
- Cardiology (10)
- Harefuah (7)
- Israel journal of medical sciences (5)
Tel Aviv Sourasky Medical CenterTell Afif, Tel Aviv, Israel
Sheba Medical Center
Gan, Tel Aviv, Israel
- • Department of Pathology
- • Department of Medicine B
Tel Aviv University
Tell Afif, Tel Aviv, Israel
- Department of Internal Medicine


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Best breakfast we had on our Costa Rica trip was at Soda de Sirenita in Santa Teresa. Highlight: best banana pancakes ever!. Located near the fork road at Mal Pais and the road into Santa Teresa on the right just past the 2 banks and ice cream shop. It opens before 8am unlike most other breakfast joints in town. Outdoor covered patio area with 4-5 tables.
We also loved Burger Rancho. Yes, they have burgers, but that is only a small part of their local cuisine menu. The sword fish and chicken dinner entrees were great. Another good sign - the locals seem to like the place, too, as we saw as many or more to-go orders going out the front as being served at the tables. Outdoor covered patio with 7-8 tables and free wireless internet access.
Note: Throughout most of rural Costa Rica, nearly all small restaurants are staffed by only 1-3 people - your cook might even be your waiter. Expect service to be slow but the payoff is great food! We loved the food in Costa Rica! Just have a beverage and enjoy the experience.

subset: commoncrawl


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The goal of the William K. Schubert Minority Nursing Scholarship Program is to increase the diversity of registered nurses at Cincinnati Children's Hospital Medical Center and in our community. The program grants awards annually to assist with tuition and fees for individuals who are preparing to be pediatric registered nurses that provide patient care. These scholarships reflect a major commitment on the part of Cincinnati Children's to assist with economic barriers that prevent some students from pursuing nursing careers.
Student should be a member of one of the underrepresented groups in the registered nursing profession. Underrepresented groups include male nurses / nursing students and nurses / nursing students who are American Indian or Alaskan Native, Black or African American, Hawaiian Native or other Pacific Islander, Hispanic or Latino, and / or Asian including Chinese, Filipino, Japanese, Korean, Asian Indian, Thai, or Vietnamese/Southeast Asian.
Student must be enrolled or accepted in a professional registered nurse program (bachelor's or master's degree) at an accredited school of nursing on a full-time or part-time basis.
Student must be seeking initial licensure as a registered nurse in the State of Ohio.
Student must have and maintain a minimum GPA of 2.75 on a 4.0 scale.
If the student is a current Cincinnati Children's employee, he/she must NOT be eligible for benefits under the Medical Center's Tuition Reimbursement policy.
The award is a maximum of $2,750 per year. Funds are prorated for part-time enrollment status. Maximum time is extended for part-time study. Funds are sent directly to recipients' schools to be used for tuition and fees only, not for living expenses.
Selection Process
Selections are made once per year and will be determined by the Scholarship Committee. The annual deadline for submitting a completed application is April 30. Early submissions are encouraged. Scholarship recipients will be evaluated based on the contents of their application packet and the completion of one video interview. Selections are announced on or before July 15.
$2,750 per year for up to 4 years (up to $11,000)
Scholarship is offered annually with the deadline always on April 30 each year.
If you have ever had a loved one that needs caring, if you have ever cared for a loved one, or if you have ever been a part of the caregiving process you know exactly how important these professionals are to each and everyone of our families.
Part of our mission here at CNAthrive.com is to help to cultivate and develop the care givers of the future. We do this by collecting and putting together the CNA Thrive, Thriving Care Givers Scholarship. This award is given out each year to as many candidates as we can afford to sponsor. The scholarship is given to candidates who are working to become caregivers but do not have the financial means to attend an educating institution.
Candidates are chosen based upon the following criteria:
- Current education
- Must be applying or attending a Nursing, LPN, or CNA Program
- Creativity and effort put into their application project
Candidates who are awarded this scholarship will receive up to $600-$1500. Upon completion of the course the candidate will be asked to come back to CNAthrive.com to share their experience and stories.
Applications for the scholarship go out November 1st however it is important that you sign up to receive your application below. The deadline for all applicants will be March 31st.
The scholarships are awarded once per year on June 30th, when we celebrate our National Caregiver Day.
If you would like to donate to the Thriving Care Givers Scholarship, please donate here:
The Charlotte McGuire Scholarship Program (CMGSP) was established in 1986 through a gracious gift to the American Holistic Nurses Association. Since 1987, AHNA nurses in pursuit of their professional education have been assisted by this program. These awards celebrate the commitment of nurses to a holistic path, and are presented at AHNA's annual conference held each year in June. Since 1997, more than $30,000 has been awarded.
Named in honor of the founder of AHNA, the Charlotte McGuire Scholarship Program is made possible through the generous tax deductible donations of AHNA members, friends and benefactors. The purpose of this awards is to recognize and celebrate nurses in an undergraduate or graduate academic setting dedicated to a practice of holistic nursing.
Annually, the CMGSP offers academic scholarships to nurses in undergraduate nursing programs, graduate nursing programs, and other graduate programs related to holistic nursing.
Application Criteria
Charlotte McGuire Education Scholarship Program – Undergraduate nursing Students Award are available to nurses who:
- Current R.N. Licensure
- Current active member of AHNA for a minimum of six (6) months
- Enrolled in an undergraduate academic setting dedicated to a practice of holistic nursing
- Ability to incorporate self-care into personal and professional life
- A demonstrated commitment to holistic nursing practice and its philosophical base
Charlotte McGuire Education Scholarship Program – Graduate nursing Students Award are available to nurses who:
- Current R.N. Licensure
- Current active member of AHNA for a minimum of one (1) year
- Enrolled in a graduate academic setting dedicated to a practice of holistic nursing
- Ability to incorporate self-care into personal and professional life
- A demonstrated commitment to holistic nursing practice and its philosophical base
- Proven commitment to advancing Holistic Nursing using Leadership Skills
Application Procedures
Application packets may be downloaded or are available throughout the year from AHNA National Office. Completed applications must be returned by
April 15
of the year for which the scholarship is awarded. Applications received after April 15 will not be considered. No materials will be returned to the applicant. The application includes:
- Personal Data
- Educational and Employment History
- Description of personal philosophy and activities
- Official transcript
- Application Form
- Two sponsorship letters (one must be written by an AHNA member)
Selection Process
All applications are reviewed by members of the Charlotte McGuire Scholarship Program Committee. The committee is composed of active AHNA members, one of whom is a chair appointed by the Board of Directors. Selection criteria have been approved by the Board of Directors. Scholarship recipients will be notified each year in May. All recipients are encouraged to attend the national AHNA conference to receive awards.
Amount of Scholarships
The Scholarship Program is supported by donations from AHNA members, friends and benefactors. Final determination is made by the Board of Directors.
For Questions Contact:
Peggy Burkhardt
AHNA President Elect
(304) 673-7215
Submit Applications to:
AHNA Office Manager
100 SE 9th Street, Suite 3A
Topeka, KS 66612-1213
(785) 234 – 1713 (fax)
Scholarship awards are presented to NAHN members enrolled in accredited LVN/LPN, associate, diploma, baccalaureate, and graduate nursing programs.
Selection of recipients is based on need, current academic standing, whether they are a United States citizen or legal resident of the United States and other criteria listed below.
Scholarship recipients are a select group of Hispanic nursing students who demonstrate promise of professional contributions to the nursing profession and who have the potential to act as role models for other aspiring nursing students.
The number of scholarships offered each year is dependent upon the amount in the scholarship fund.
Scholarships will be presented at the 2015 NAHN Annual Conference.
What is the Selection Criteria?
Criteria for the Scholarship Awards include:
- NAHN scholarship application form completed by the student and submitted by the deadline date.
- Two (2) Letters of Recommendation from two faculty members outlining the applicant's future professional contribution to the nursing profession and potential to act as a role model for other aspiring nursing students.
- An essay, 500 words or less (using Times New Roman – 12 font), written by the student that reflects their life growing up (must include who raised them and what type of work they did), qualifications, and potential for leadership in nursing
- A resume, which includes earned certificates, awards, community service and special honors.
- Provide one page essay that includes: a discussion of economic needs; delineates monthly income and expenses; estimates of educational expenses, including any other financial aid for the year requested. Include also a copy of most recent W-2 form.
- An official transcript from applicant's college, university, or Nursing Program.
- Please do not staple all these documents.
- Academic standing (minimum GPA of 3.0 preferred).
- Verification of membership status in NAHN (must be a NAHN member for at least six months).
- NAHN members can reapply for scholarships if attaining a higher degree.
- No acting National Board Members or Awards & Scholarships Committee members are eligible for scholarships
Scholarships in the amount of $1,000 to $2,000 for undergraduate nursing students who are entering their senior year of nursing school. Deadline is April 30th of each year. Visit website for latest information.
The Kansas Nursing Service Scholarship requires an obligation to practice as a LPN or RN in Kansas and work for a sponsor. A sponsor means any adult care home, psychiatric hospital, medical care facility, home health agency, local health department or any state agency, which employs LPNs or RNs, licensed by the State of Kansas. The sponsor will provide partial scholarship funding and provide employment upon licensure of the recipient. Recipients must sign an agreements to practice nursing for a sponsor one year for each year of scholarship support. Priority Deadline: May 1.
- Online Form
- Information (pdf)
- Nursing Sponsorship Agreement (pdf)
Minority Nurse has teamed up with NCEMNA to co-sponsor an annual scholarship to help outstanding nurses from underrepresented groups complete their studies toward a Bachelor or Master of Science in Nursing. To date, we have awarded scholarships to more than 40 students, honoring their commitment to the profession, academic excellence, and community service.
We are currently accepting applications for our 16th annual scholarship competition, consisting of two $1,000 awards and one $3,000 award. Scholarships will be paid in summer 2015 for the fall 2015 academic term.
Who is Eligible
To apply for this scholarship, students must meet all four of the following criteria:
- Be a minority in the nursing profession
- Be enrolled (as of September 2015) in either the third or fourth year of an accredited BSN program in the United States OR an accelerated program leading to a BSN degree (such as RN-to-BSN or BA-to-BSN) OR an accelerated master's entry program in nursing for students with bachelor's degrees in fields other than nursing (such as BA-to-MSN). Graduate students who already have a bachelor's degree in nursing are not eligible.
- Have a 3.0 GPA or better (on a 4.0 scale)
- Be a U.S. citizen or permanent resident
How to Apply
Complete and return this form along with all three of the following documents:
- Transcript or other proof of GPA
- Letter of recommendation from a faculty member outlining academic achievement
- A brief (250-word) written statement summarizing your academic and personal accomplishments, community service, and goals for your future nursing career
Important: An English translation must be provided for any documentation that is not in English.
The Eight and Forty Lung and Respiratory Disease Nursing Scholarship was established to assist registered nurses with advanced preparation for positions in supervision, administration or teaching. Students must have employment prospects in specific positions in hospitals, clinics or health departments upon completion of their education, and the position must have a full-time and direct relationship to pediatric lung and respiratory control.
Aid offered
Scholarship awards are $5,000 each.
Applicants must have a current registered nurse license.
Deadline for application is May 15, and recipients are announced July 1.
For more information:
NAANA is pleased to announce its annual scholarships, awarded to the most meritorious applicants who are engaged in studying nursing at the Associate Degree, Bachelor degree, Master's degree or RN-BSN levels. Annually, awards are made, $500 to $1000 each, depending on the funds available in a given year for scholarships. The awards may be applied toward tuition and/or books in a given academic year.
Applicants must be enrolled in an accredited nursing program at the time of application, and should be pursuing a nursing program during the year for which the award is made. In order to be eligible, applicants must be of Arab heritage, citizens or permanent residents of the United States, and must reside within the US or its territories; further, applicants must be members of NAANA.
Provides scholarships for nursing students pursuing BSN, RN-to-BSN, MSN or PhD degrees. Must be a Mississippi resident attending a Mississippi school and agree to work as a nurse in Mississippi upon graduation. Also offers a Nursing Teacher Stipend Program for graduate students who agree to teach at an accredited nursing school in Mississippi.


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Comment: Lack of faith. (Score 1) 121
by carbontetra (#15978314) Attached to: More WoW, Major 2007 Announcement for Blizzard
I suspect that this announcement will be something regarding starcraft or a diablo MMO. But, truth be told, I'm not really happy with Blizzard right now. World of Warcraft was my drug of choice for a good long while, but it got very frustrating towards the end. Aside from the infighting in my guild, the drop rates for gear as well as the vast imbalance between a few classes in PvP and PvE, I've lost faith in Blizzard. I don't think they can make good dames like Diablo, Diablo II and Starcraft again, I think that they're entirely too happy to suckle at the MMO money teat. I don't blame them, however. They're in this business to make money, but as of this moment, approximately 5 months away from 2007, I am just not excited about their announcement of an upcoming announcement.


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Writing Elsewhere
On the Lettuce Edge
notes on farming, parenting and Jewish life, by Tanya Tolchin
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Weather Drama and Learning About Snow
What better time to start a weather unit than the famous month of March. We are definitely still in the "in like a lion" phase and there are plenty of teachable moments happening right outside our classroom doors! And most of our students have enjoyed extra outdoor time on our...
Writing Down Writing Goals
It is resolution season (eye rolls allowed) and most of us have some. I spent New Years Day cleaning the house and wondering how we got to 2015 without any housecleaning robots. Really, there are smart phones and drones but somehow it is still mostly up to women to get...
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I published a couple of new articles this month that I want to share here. One is a piece about my grandfather's NYC fruit and vegetable store and the second is on trying to embrace the temporary during sukkot. Maybe you want to click over and read them. Lots of...
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Well my tech free summer is over so I hope to return to this blog and I hope some of my readers are still with me. We are harvesting winter squash and fall greens and getting ready to celebrate Rosh Hashanah. I want to share a new piece I have...
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It is finally spring on the farm and things are moving really fast right now. We are starting our CSA shortly, asparagus and lettuce are coming in and crimson clover is turning the fields red with flowers. Crimson clover is a cover crop that helps feed the soil by fixing...
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About CTOT Training
"A public/private partnership dedicated to training operators in the safe, legal and professional operation of construction trucks"
A group of highway heavy contractors along with the Minnesota Department of Transportation, the Minnesota State Patrol, and Hennepin Technical College are working together in a proactive role on the safety of trucking in the highway heavy construction industry.
Most companies indicate that large risks are in the areas of construction trucking and traffic control. The CTOT Program is intended to assist you in helping manage the construction trucking risk. Make sure if you hire outside trucking that you include them, as you plan who should attend a CTOT program.
The CTOT program is intended to assist in helping manage the risk in the construction trucking. Make sure if you hire outside trucking that you include them as you plan who should attend a CTOT program.
Qualification of Workers
Operators of construction trucks hauling construction materials such as borrow, aggregate base, asphalt mixtures and concrete paving mixtures are encouraged to become trained in CTOT.
The objective of the training is to make the driver aware of the Federal and State requirements and regulations regarding the construction truck and driver and the safe driving techniques that will result in the safe operation of the construction truck. Presenters are from the Minnesota State Patrol, Minnesota Department of Transportation and Hennepin Technical College.
Contact Information
For additional information, to schedule a customized class, or to get out-of-state pricing please contact:
Erik Gohl, Industrial Safety Coordinator
Or write to:
Hennepin Technical College
Customized Training Services
ATTN: Erik Gohl
9000 Brooklyn Boulevard
Brooklyn Park, MN 55445-2389
"Duininck has used CTOT from it's inception. We send all our commercial drivers license holders through some level of CTOT training every year. This training keeps our drivers up to date on construction truck regulations, truck inspections, brake adjustment, load securement, hazardous material handling, safe vehicle operation including behind the wheel vehicle dynamics and safe driving techniques. The financial rewards to our company in both reduced premiums and low losses make this program one we are unwilling to change. This CTOT training has proven to be extremely cost effective."
Rick Maursetter, Risk manager, Duininck, Inc.
"Kevin Vito conducted several 8-hr HazMat Recertification Classes for our Emergency Response Team. His combination of creative hands-on exercises, examples shared from actual events, and up to date best practices techniques kept both our new members and experienced veteran team members engaged and participating for the full 8 hours. Even with my 15+ years of experience attending and conducting this type of training class, I picked up several new things. I highly recommend Kevin Vito and Hennepin Technical College for effective hazardous material and emergency response team training."
Scott Norman, EHS Manager, Cypress Semiconductor
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Last updated by lgoff : 2014-12-31 10:47:40


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In a late Friday afternoon document dump, the Justice Department finally released a heavily redacted report addressing the ethical lapses of the torture lawyers: John Yoo, now a professor at the University of California at Berkeley; Jay Bybee, now a judge at the United States Court of Appeals for the Ninth Circuit; Steven G. Bradbury, now a partner at Dechert LLP; and others at the Office of Legal Counsel. The professional staff in the Office of Professional Responsibility, charged with reviewing OLC actions, concluded that Yoo and Bybee had engaged in serious professional misconduct and that their cases should be referred to appropriate state bar disciplinary organs for review and further action. In an unusual addendum, however, Associate Deputy Attorney General David Margolis overruled the OPR findings, concluding that the conduct of the OLC lawyers did not rise to the level of "professional misconduct." Margolis argued that OPR had failed to elaborate clear standards against which the lawyers could be judged.
The Margolis addendum, by arguing essentially that nothing can be done, raises a critical question: Is the Justice Department any longer capable of policing itself? The question has little to do with the torture issue, important as that is, or with partisan politics in general. It is clear now that the OPR itself is totally dysfunctional. The institutional ethos is now simple: the client is the president, and the department should do what it takes to make the client happy. Lawyers who serve their client will be protected and exonerated, even if they commit serious crimes in the process. Lawyers who cross the client are in serious trouble, even if they have only acted because of ethics requirements.
This mindset has survived the recent transition. Consider, for instance, the much ballyhooed public-integrity prosecution of former Alaska Senator Ted Stevens, a Republican. A conviction was secured, but soon thereafter it became apparent that the prosecution team had committed public corruption crimes potentially more serious than those they had charged against Stevens. The prosecutors now face a criminal inquiry themselves—and none of this happened as a result of internal Justice Department ethics action. Indeed, the Justice Department reacted to repeated warnings and inquiries by Judge Emmett Sullivan by doing absolutely nothing.
Or consider the New Year's eve decision by Judge Ricardo Urbina to dismiss the department's highest profile prosecution of seven Blackwater guards in connection with the shooting of seventeen Iraqi civilians in 2007. In a 91-page-opinion, Urbina catalogued a pattern of outrageously abusive conduct by prosecutors.
Or the December 15 hearing in Santa Ana, California, in which Judge Cormac J. Carney acquitted a group of Broadcom executives. The judge proceeded to excoriate the prosecutors. They had pressured an innocent man to accept a guilty plea to help lay the foundations of their case, Carney charged. In a manner reminiscent of authoritarian societies, they had intimidated the thirteen-year-old son of one defendant in an effort to get him to provide evidence against his father. The Justice Department's conduct had been "shameful and contrary to American values of decency and justice," the judge said.
The cases of Don Siegelman, Paul Minor, Charles Walker, and others reflect still more egregious misconduct, often with a strong political element. These cases were not undertaken by out-of-control youngsters. They are among the highest profile cases in the department; they were under supervision at the highest levels. David Margolis himself repeatedly hovers in the background of these cases, saying that everything is just fine when ethics failings are spotlighted by outsiders. Margolis presents himself as an ethics expert. But his views are incomprehensible in terms of ethics. They are far better understood in terms of political convenience.
Boston NPR affiliate WBUR recently did a series of reports on the ethics implosion in the Justice Department. In the final episode, "The Judges' Rebellion," they reviewed how federal judges finally became so disgusted with the institutionalized misconduct and the Justice Department's refusal to discipline misbehaving lawyers that they began disciplining the prosecutors themselves—taking the same approach adopted by Judge Sullivan in Washington.
Fordham law professor Bruce Green, a former federal prosecutor, recently provided the ABA Journal with a disturbing slogan for OPR. "I used to call it the Roach Motel of the Justice Department," he said. "Cases check in, but they don't check out." A year after the arrival of a new president and a new attorney general, the roach motel remains in business.
More from Scott Horton:
From the April 2015 issue
Six Questions — October 18, 2014, 8:00 pm
Nathaniel Raymond on CIA interrogation techniques.
No Comment, Six Questions — June 4, 2014, 8:00 am
Mark Denbeaux on the NCIS cover-up of three "suicides" at Guantánamo Bay Detention Camp
Acreage of a Christian nudist colony under development in Florida:
Continuing Care, Inc. (Venice, Fla.)
Florida's wildlife officials decided to remove the manatee, which has a mild taste that readily adapts to recipes for beef, from the state's endangered-species list.
A 64-year-old mother and her 44-year-old son were arrested for running a gang that stole more than $100,000 worth of toothbrushes from Publix, Walmart, Walgreens, and CVS stores in Florida.
Subscribe to the Weekly Review newsletter. Don't worry, we won't sell your email address!
"He could be one of a million beach-bound, black-socked Florida retirees, not the man who, by some odd happenstance of life, possesses the brain of Albert Einstein — literally cut it out of the dead scientist's head."


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daily news, stories, events, blog posts, videos and photos
02.11.15 Backcountry Ski Tips: How to Fix a Broken Ski Pole A broken ski pole in the backcountry can be devastating. But here's an easy fix.
related tags:How to Ski, Backcountry, Skiing Adventure, Skiing Culture, avalanche safety, backcountry ski tips, Ski Tips
02.10.15 The Shadow Campaign A new series of ski film shorts by DPS Cinematic features storm-chasing and deep-powder riding.
related tags:Destinations, Skiing Adventure, Skiing Culture, Photos and Movies, ski film, DPS
02.09.15 Trip Ideas: Heavenly Mountain Heavenly may not be as burly as other mountains, but you should consider it.
related tags:Destinations, Resorts, Skiing Adventure, Mountain guide, Travel Ideas, trip ideas, California, Nevada, Sierra, Heavenly
02.09.15 JP Auclair Tribute Film and Auction Proceeds from this online fundraiser will support the son and partner of the late freeskiing great as well as the charitable organization he founded, Alpine Initiatives.
related tags:News, Athletes, Skiing Culture, alpine initiatives, JP Auclair


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Effects of a Concussion May Last Longer than Symptoms, Study ShowsMarch 01, 2012
Currently, concussions are diagnosed and monitored through a patient's self-reported symptoms (including headache, confusion or disorientation, poor concentration, and memory loss) and through computerized neuropsychological testing programs, which measure cognitive abilities including attention and concentration, cognitive processing, learning and memory, and verbal fluency. Post-concussion abnormalities in either of these markers typically return to a normal level within five to 10 days following the injury.
Conducted while he was a graduate student at the University of Virginia, Livingston's study was just published in the February 2012 issue of the Journal of Clinical Neurophysiology. The study used motor-evoked potentials (MEPs) - an electrophysiological measurement that can provide hard evidence for changes in brain function - to determine if any physiological abnormalities followed a similar recovery pattern to self-reported symptoms and neuropsychological testing.
During an MEP test, subjects have electrodes placed on a limb - such as the hand or foot. A magnetic stimulating device is placed over the head, and they receive a brief pulse of magnetic stimulation to the brain. The "reaction time" - the amount of time it takes for the subject's limb to receive the response from the brain after the stimulation - is recorded.
Livingston's study enrolled 18 collegiate athletes - nine who had been concussed within the previous 24 hours, and nine who had not experienced a concussion. Each concussed subject was matched with a non-concussed subject using age, gender, sport, position played, prior concussion history, and history of learning disability or attention deficit-hyperactivity disorder as inclusion criteria.
Subjects were evaluated for evidence of concussion based on self-reported symptoms, computerized neurocognitive test performance, and MEPs for a period of 10 days. Post-concussion symptoms were more frequent and greater in severity in the immediate timeframe after the injury (24-72 hours) and decreased in the following days. Some subjects reported no symptoms by day 10, though others did not have complete symptoms resolution by that time. Neurocognitive deficits followed a similar pattern, proving greater just after the injury and returning to normal (or closer to normal) by day 10.
MEPs, however, showed delays in response time and smaller MEP size which continued up to day 10, with these physiological changes actually increasing as the concussed athletes' symptoms decreased and cognitive functioning improved.
Livingston, director of the UK Concussion Assessment Research Lab and assistant professor in the Department of Rehabilitation Sciences, says these findings are significant for both athletes and sports medicine clinicians.
"Further investigation of MEPs in concussed athletes is needed, especially to assess how long the disturbances in physiological functioning continue after those initial ten days post-injury," Livingston said. "But in the meantime, sports medicine personnel caring for concussed athletes should be cautious about relying solely on self-reported symptoms and neurocognitive test performances when making return-to-play decisions."
Livingston's research lab recently began a new program to further study MEPs in athletes pre- and post-concussion. At UK, all athletes who participate in a contact sport - including football, soccer, volleyball, diving, gymnastics, and basketball - are assessed preseason using MEP and neurocognitive testing to establish a baseline measure for each athlete.
If an athlete receives a concussion, he or she will come back to the lab as soon as possible after the injury for follow-up testing. This approach allows researchers to get a clearer idea of the extent of an athlete's injury, Livingston says.
Neurocognitive tests, such as the Immediate Post-Concussion Assessment and Testing (ImPACT)™, are a valuable component of concussion management. While major professional sports organizations like the NFL and NHL, as well as hundreds of colleges, universities, and high schools across the United States follow this standard, UK Athletics did not have a formal, standardized neurocognitive testing protocol in place until last year. The addition of the MEP assessment in the preseason testing and post-concussion management are unique - UK is the first and only collegiate athletics program to implement a baseline physiologic measure of brain function.
"No other college of university in the country is currently assessing physiologic brain responses and using this information to determine the extent of the functional brain injury," Livingston said. "This type of information enables us to closely track recovery, which may not correspond to the decrease in concussion symptoms or recovery of memory and other cognitive functions."
Learn more about concussion research at UK with Drs. James Jagger, Dan Han, and Scott Livingston in "UK at the Half," a radio interview broadcast at halftime of the Feb. 11 UK-Vanderbilt basketball game.
University of Kentucky
Related Concussion Current Events and Concussion News Articles
Finding a new test for children with concussions
Researchers at the Montreal Neurological Institute and Hospital -The Neuro, at McGill University and the MUHC, are working to develop a much needed tool for helping diagnose concussions or mild traumatic brain injuries suffered by thousands of young Canadians ---hockey and football players among them.
Mental health soon after war-zone concussions predicts disability
Evaluating military personnel with blast-related mild traumatic brain injuries, researchers have found that early symptoms of post-traumatic stress, such as anxiety, emotional numbness, flashbacks and irritability, are the strongest predictors of later disability.
Expanding sports concussion laws may help ensure safety of all teenage athletes
Recent concussion laws that set out to prevent head injuries in American teenage athletes should be extended to include the activities of summer camps, travel teams and all-star teams.
Novel eye-tracking technology detects concussions and head injury severity
New research out of NYU Langone Medical Center could move the medical community one step closer toward effectively detecting concussion and quantifying its severity.
New recommendations for return to activity after concussion in military personnel
Military service members with mild traumatic brain injury (mTBI), or concussion, should follow a six-step process of progressive activity, leading to return to active duty, according to new clinical recommendations by an expert panel.
Lost memories might be able to be restored, new UCLA study indicates
New UCLA research indicates that lost memories can be restored. The findings offer some hope for patients in the early stages of Alzheimer's disease.
New technology advances eye tracking as biomarker for brain function and brain injury
Researchers at NYU Langone Medical Center have developed new technology that can assess the location and impact of a brain injury merely by tracking the eye movements of patients as they watch music videos for less than four minutes, according to a study published Friday on-line in the Journal of Neurosurgery.
Do concussions have lingering cognitive, physical, and emotional effects?
A study of active duty U.S. Marines who suffered a recent or previous concussion(s) examined whether persistent post-concussive symptoms (PPCS) and lingering effects on cognitive function are due to concussion-related brain trauma or emotional distress.
High school football players show brain changes after one season
Some high school football players exhibit measurable brain changes after a single season of play even in the absence of concussion, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).
Danger of repeat head injuries: Brain's inability to tap energy source
Two or more serious hits to the head within days of each other can interfere with the brain's ability to use sugar - its primary energy source - to repair cells damaged by the injuries, new research suggests.
More Concussion Current Events and Concussion News Articles


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If the logistics allowed it, Seattle Seahawks quarterback Russell Wilson would be playing in both the National Football League and Major League Baseball. Last week on MLB Network Radio, Wilson's agent, Mark Rodgers, said that if Wilson "could figure out … Continued
Russell Wilson's agent: QB would play baseball too if he could
Artie Lange, Jo Koy and more comedians make Super Bowl predictions with Ron and Fez
All this Super Bowl talk can get repetitive, with the same pigskin experts over-analyzing in all the time. Lucky for us, Ron and Fez brought in some of the funniest people they know to predict the result of Sunday's big match-up. … Continued
Darrelle Revis vs. Richard Sherman: Antonio Cromartie breaks it down
Barring unforeseen circumstances, they won't line up opposite each other in Super Bowl XLIX. But one of the most intriguing match-ups in Sunday's NFL championship between the New England Patriots and Seattle Seahawks is the battle between each team's No. … Continued
Super Bowl XLIX scouting report: Seahawks-Patriots match-ups, key players
Celebrity predictions are great and all, but how about the nitty gritty? When the New England Patriots and Seattle Seahawks step on the field Sunday in Arizona, what should true football fans be looking out for? SiriusXM NFL Radio's Jim … Continued
We will rock you: Listen to 24/7 pump up the jams for Super Bowl weekend
Airing Saturday 1/31 at 6 am ET through Sunday 2/1 at midnight on Ch. 147 We Will Rock You. We Are the Champions. Start Me Up. All I Do is Win … the Super Bowl is all about tough competition, so … Continued
Tom Brady vs. Russell Wilson: Who's better long-term?
Two of the league's most clutch quarterbacks, Tom Brady and Russell Wilson, will face off Sunday in Glendale, Ariz. That begs the question: All things considered equal, who would you rather under center for Super Bowl XLIX? Or how about for … Continued
Super Bowl XLIX: Notable predictions from the sports world
Current and former NFL coaches and players, analysts, prominent sports figures, celebrities and SiriusXM hosts make their predictions for Super Bowl XLIX. Check back often, as we'll add predictions all week. Sidnew Rice, former NFL wide receiver I'm definitely rooting … Continued
Dog bites: #Deflategate
Made-up sayings. Criss-crossed literary references. Yelling. Lots of yelling. Mad Dog's take on #Deflategate had it all. Thursday on his Mad Dog Sports Radio program, Chris Russo went after Tom Brady, Bill Belichick, Bob Kraft, the New England Patriots, Roger … Continued
Chad Pennington reminisces about forcing Patriots' switch to FieldTurf
In Week 10 of the 2006 NFL season, Chad Pennington and the Eric Mangini-led New York Jets went to Gillette Stadium and beat the New England Patriots on the road, 17-14. Rain on gameday led to poor field conditions throughout … Continued
Sorry, Jets fans: Tom Brady won't be riding off into the sunset
If AFC East teams were looking for a silver lining in the New England Patriots' trip to Super Bowl XLIX, they're not going to find it here. This week on SiriusXM Bleacher Report Radio, Ben Volin, the Patriots' beat writer … Continued


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Tuesday, December 13, 2011
Download Makalah : Tujuan dan Fungsi Perencanaan Pembelajaran
4 comments:
- Lux said...
oke deh
- May 18, 2012 at 10:01 PM
- obat keputihan said...
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- September 7, 2012 at 8:29 PM
- cafemuslim said...
- October 20, 2012 at 12:58 AM
- co wendy said...
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- January 2, 2015 at 5:43 PM
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Eastern District of Michigan Real Property Cases
Foreclosure Cases, Dockets and Filings
Cases filed
Cases 1 - 10 of 1,151
Kassab v. Seterus, Inc. et al
as 2:2015cv11228
Plaintiff: Wilson Kassab
Defendant: Seterus, Inc., Federal National Mortgage Association, Successors in Interest or Assigns, Federal Housing Finance Agency and others
Cause Of Action: Petition for Removal
Type: Real Property Foreclosure
White v. Coleman et al
as 2:2015cv11127
Plaintiff: William Sylvester White
Defendant: Alicia Jones Coleman, Pensco Trust Company, Angelo S. Dimeo and others
Yunis v. Smith et al
as 2:2015cv11129
Plaintiff: Ramzu Yunis
Defendant: Charles Smith, Bank of America, N.A., as successor by merger to LaSalle Bank National Association, as Trustee, a Foreign Corporation, jointly and severally
Mohlman v. Deutsche Bank National Trust Company
as 2:2015cv11085
Plaintiff: Brent Mohlman
Defendant: Deutsche Bank National Trust Company
Hogan v. Visio Financial Services Inc.
as 2:2015cv10923
Plaintiff: Phillip Wendell Hogan
Defendant: Visio Financial Services Inc.
Bank of America, N.A. v. Vacca et al
as 2:2015cv10906
Plaintiff: Bank of America, N.A.
Defendant: Salvatore Vacca, Eileen Vacca, Americo Mauti and others
Sherman et al v. MGC Mortgage et al
as 2:2015cv10881
Plaintiff: Robert Sherman , Donna Sherman
Defendant: MGC Mortgage , LNV Corporation
O'Neal v. Bank of America, N.A. et al
as 2:2015cv10875
Plaintiff: Fannie O'Neal
Defendant: Bank of America, N.A., Green Tree Servicing, LLC
Heath v. CitiMortgage, Inc.
as 2:2015cv10824
Plaintiff: Joanne K. Heath
Defendant: CitiMortgage, Inc.
Collins v. CitiMortgage, Inc.
as 2:2015cv10858
Plaintiff: Carolyn M. Collins
Defendant: CitiMortgage, Inc.


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Need snake id please
I've been seeing a small snake in the pipe that drains out from our sump pump. The snake could easily crawl back into our house through this pipe so I want to know what it is.
The pipe is about 2 inches across to give you an idea of the size.
I lightened the photos a little, zoomed and cropped so you can see the spots/patches. I couldn't get a profile shot or get close enough to see whether his pupils were round or not. They look round in my photo but I'm not sure that it's very accurate from the angle.
If I were in that situation, I would fill the pumps container with water to flush him out. then immeadiatly apply a screen before he could get back in. Then set up some type of area in the yard to hold water for his use somewhere els if that is why he goes in there. If he is just looking for shelter then maybe a small wood pile in the back of the yard or something like that.
I spotted my first snake her a few weeks ago. It was a black racer. Been here 5 years and that is all I have seen. I go looking for him every day now but no luck seeing him again. I hope to have better luck once I put in a frog pond!


text: I dont watch MTV very much but others say that it ruined the musical world and I find this confusing. Are people trying to say its about the music not the video? I kinda brought this up because of "School of Rock" Jack Black. "Rock was stickin it to the man. But the man ruined it with a little thing called MTV!" That was a good movie.


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Quick Response Manufacturing //
A powerful tool for reducing lead times in all phases of manufacturing and office operations
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QRM Center
The QRM Center is a partnership between companies, faculty and students at the University of Wisconsin-Madison, dedicated to the research and implementation of lead time reduction principles.Learn more about what we do and how to join us.
Since 1993, the QRM Center has worked with more than 200 companies to reduce lead times. For many, QRM implementation brought some impressive results.Check results reported by QRM companies and read what industry professionals have to say about them.
QRM Center News
How does a multinational organization made up of 4,000 employees of different cultures who speak different languages and perform different functions at sites in 30 countries develop a dominant, enterprise wide, unifying strategy that is understood and embraced by all? Marel, which designs and manufactures highly customized food-processing equipment, faced that challenge after nearly three decades of expanding through acquisitions. It purchased Stork Food Systems in 2008, a firm with U.S. roots dating to the 1850s that had its own blend of acquisitions, history, culture and manufacturing practices. Equal in size to what Marel had become, Stork introduced even greater diversity into the parent company's operations and culture. With the acquisition of Stork, Marel's international profile now...Written on 27 January 2015Read More
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Apr 28, 2015 - Apr 28, 2015
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Get a full understanding of the QRM strategy at this hands-on workshop covering all aspects of QRM and providing a roadmap for implementation at your company.
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text:
Our special coverage of the closest race for years
Meet Malaysia's first female mixed martial artist
07 Sep 2007 08:02 GMT | Human Rights, Arts & Culture
Born and raised in the Brazilian city of Rio de Janeiro, Coelho has walked a turbulent path in life.
After a youth filled with rebelliousness, drug use and jail time, he found himself on a spiritual search during which he pursued Eastern religion, mysticism and black magic.
These experiences led to the creation of most of his works for which he is most famous. In May 2007 his latest work, 'The Witch of Portobello' was published.
On Thursday's 'Riz Khan' we speak to Brazilian author, lyricist and novelist Paulo Coelho.Best known for his novel 'The Alchemist', Coelho's has sold over 92 million books and his works have been translated into 66 languages in more than 150 countries around the world.
Watch the episode here:
Watch Street Talk here:
Watch Al Jazeera English programmes on YouTube
Join our debates on the Your Views section of the site
Recent court ruling finds police unit not guilty of rounding up and executing 42 Muslim men during 1987 communal riots.
Human Rights, India, Asia
Nigerians are flooding home for Saturday's vote, but fears of violence grow amid the too-close-to-call election.
Nigeria Decides, Nigeria, Africa
More than 800 people were killed and 65,000 displaced in religion-based election violence in 2011 in the central city.
Nigeria Decides, Nigeria, Goodluck Jonathan
More than 100 people were gunned down in Maidan Square a year ago, but investigations have failed to bring prosecutions.
Human Rights, Politics, War & Conflict
It is a source of sustenance but also of tension and new political realities are now increasing uncertainty.
Egypt, Sudan, Middle East
A media post-mortem into the UK's surveillance report. Plus, why five years on in Argentina the media looks so familiar.
Media, Edward Snowden, Security
The untold story of how the Lebanese community overcame the odds and found their place in multicultural Australia.
Asia Pacific, Australia, Lebanon
How to keep a telenovela profitable and demanding sponsors happy while inspiring the production team to stay passionate.
Arts & Culture, Mexico, Latin America


text:
What to do with small leftover flagstone pieces
New to this board. Hope I'm in the right place. We had a pool installed with flagstone and have lots of small pieces left. These might be 2" by 12" pieces, some bigger, some smaller. Was wondering if anyone had any suggestions for using them before I discarded. Thanks.
The website I am sending along is ,among other things, a school teaching how to make murrals from pieces of rock such as yours .You may need several colors .It's like doing mosaic but less teadious I would imagine ..Anyways the website is worth viewing as there is a great murral of an oldtime miner on the first page .
I am building a flagstone patio with a rock wall around 3/4's of it. Do I build the wall first or do I lay the flagstone patio first? The patio is about 10X10, and the rock wall is approx 1 1/2" high. The patio will be irregular in shape. Thank you, sandra
First off, in response to the July 23rd question I'd say to mainly be sure you don't end up with your wall sitting on top of your patio. What comes first depends on your design, and you haven't given enough information.
But then, it bears repeating: if you have a new question, start a new thread.


text:
Type: Task
Status: Open
Priority: Critical
Resolution: Unresolved
Affects Version/s: 1.9.11, 2.0.2
Fix Version/s: None
Component/s: Libraries
Affected Branches:MOODLE_19_STABLE, MOODLE_20_STABLE
This issue groups all related DST issues.
Gliffy Diagrams
Issue Links
- has a non-specific relationship to
MDL-46517 Calendar block links to incorrect day during month of DST change
- Closed
Thanks for reporting this issue.
We have detected that this issue has been inactive for over a year. It was reported as affecting versions that are no longer supported.
If you believe that this issue is still relevant to current versions (2.5 and beyond), please comment on the issue. Issues left inactive for a further month will be closed.
Michael d.
Issue 5. https://tracker.moodle.org/browse/MDL-22467 the resetting of assignment due dates over the course of DST during backup/restore is still an issue for us on 2.5. We are in America/Los Angeles Timezone and every time we do a restore into a period of time that contains a switch in the timezone our assignments are being adjusted in the restore process by 1 hour. Coming up, March 9th, our course assignments are rewritten with a due date 1 hour later than they should be.
Perhaps my issue isn't related to number 5 but and is more related to number 2 but it is a separate issue with DST during backup/restore.
Steps to create test...
1. Set your server to a time zone that shifts with DST. America/Los Angeles for instance...
2. Backup and restore a course with assignments that have correct due-dates - to a new date/time that overlaps the upcoming time change (ie. March 9 is coming up)
3. After the course is restored all of your assignment due dates will have shifted by 1 hour, forward in the case of spring, or backward in the case of fall.
Courses that have this occur require manual editing of every assignment/quiz with a due date. This can be quite cumbersome.


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KCBS-TV Los Angeles: Associate Professor of Marketing Susan Dobscha comments on holiday spending habits.
You are here
Newsroom: Media Coverage
Frankfurter Allgemeine Zeitung: Dean of Arts & Sciences Daniel Everett is profiled by one of Germany's top newspapers in
Baltimore Sun: Senior Lecturer of Law Steve Weisman discusses the benefits of marriage in
MSN Money: Senior Lecturer of Law Steve Weisman offers advice to consumers on how to avoid becoming a victim of credit card fraud in
Fox 25 Morning News: Senior Lecturer of Law Steve Weisman discusses all aspects of the WikiLeaks investigation during a live interview.
WBZ-TV: Marketing Professor Susan Dobscha discusses why
The Daily Item (MA): Center for Business Ethics Program Director Professor Robert E.
Lowellsun.com: Marketing Lecturer Jim Pouliopoulos explains his successful transition from a full time job at IBM to launching his own comp
MSNBC.com: Management Professor Aaron Nurick explains what employees consider the qualities of a good and bad l


text:
Visit includes tour of manufacturing plant
ELGIN, Ill. (Feb. 23, 2015) – Elgin Sweeper, a division of Federal Signal Corporation and the leading manufacturer of street sweepers for general street maintenance, special industrial and airport applications, recently hosted a visit by Congressman Peter Roskam (R-IL), who represents the 6th District of Illinois. During his visit to Elgin Sweeper, Roskam toured the manufacturing plant, viewed the assembly of the company's street sweepers and met with employees. A strong advocate for manufacturers in Illinois, Roskam complimented Elgin Sweeper's success domestically and internationally and congratulated the company on its impressive 101-year history.
Ideal for vacuuming water off track surface and picking up debris and oil-dry
ELGIN, Ill. (Feb. 11, 2013) – Elgin Sweeper has introduced a modified Crosswind® Specialty Track Sweeper that is set to make its debut at NASCAR (the National Association for Stock Car Auto Racing, Inc.) racetracks around the country this racing season, beginning with the Daytona 500 on Feb. 24.
Technology delivers increased fuel efficiency, reduced CO2 emissions and reduced noise
ELGIN, Ill. (Aug. 22, 2012) – Federal Signal Corporation's Environmental Solutions Group today announced an initiative to develop and deploy environmentally sustainable products that have the potential to increase energy efficiency and enhance air and water quality in communities around the world.
Sweeper provides big machine performance, maneuverability of a smaller sweeper, no CDL required
ELGIN, Ill. (June 4, 2012) – Elgin Sweeper Company, Inc., the leading manufacturer of street sweepers for general street maintenance, special industrial and airport applications, today announced it has entered into a marketing agreement with Challenger Manufacturing Ltd.
Elgin Sweeper Company
A Subsidiary of Federal Signal Corporation
1300 West Bartlett Road
Elgin, IL 60120
Phone: (847) 741-5370
Fax: (847) 742-3035
Parts & Service: (877) 800-1111
Copyright Elgin Sweeper Company
© All rights reserved worldwide
Parts Literature
Rebuild Program
Technical Info
Find a Dealer
Contact Us Form
Purchasing Contracts
GSA Contract
NJPA Contract
HGAC Contract


text:
Imagination Technology Buys MIPS 56
from the gotta-catch-em-all dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
Which has turned into a complete dogs dinner in the last couple of decades first with the FPU stack based instructions being glued to a register based architecture then all the endless psuedo parallel long word instruction sets intel have thrown at their cpus like confetti. Its long been said that compilers make a better job of generating assembler than a human, but these days I doubt if a human could even grok the entire x86 instruction set to start with. I gave up long ago.
Fun (if you're into that sort of thing) discussion of the early days of MIPS at the Computer History Museum in 2011. http://www.computerhistory.org/events/video/?videoid=3paiCK3dlK0 [computerhistory.org]
% APL is a natural extension of assembler language programming; ...and is best for educational purposes. -- A. Perlis