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pruning montauk daisy
can I still successfully prune my montauk daisies this late since there are no buds? I neglected to do this earlier in the month to prevent floppage. As always, I appreciate the help.
I've heard it's best to prune them in early spring and again sometime in mid-summer (I think) to control size/height/width. Normally they bloom here in early October. I haven't pruned mine the past two years and have left them pretty much to themselves but they seem happy thriving on neglect.
My guess would be you could prune them now without adversely affecting their normal bloom time.
Best of luck!
Hmm, I didn't know it was supposed to be too late. I was just looking at them yesterday thinking I need to cut them back. Of course, I didn't but I plan to this week.
I guess that's not really "advice", lol, but I'm thinking they're pretty hardy and will do fine. I definitely would rather attempt to prune them than to have them sprawl later on.
I cut mine down last week. This is only my first full season with them after being planted last August, so I also hope it is not too late. I assumed they are like most chrysanthemums which follow the general rule no later than July 4th. They are already showing signs of new growth at the leaf axils.
I have read these are very easy to root from cuttings just shoved into the soil (like sedum) but I am running out of room and didn't try this, LOL!
I planted this and many other single-flowered mums (the so-called Korean mums) for fall color and especially as a late food source for pollinators.
sukie9 - it's likely not an issue to prune many perennials early in the season in order to delay/increase their bloom season/output or control their habit. Sunflowers might not take to such treatment and may fail to bloom but in my experience sedum, Montauk daisies, asters & balloon flower seem to thrive when they're treated to an early season trimming.
While I've yet to trim them back in fall, my winter sown (grown from seed) Siberian iris are extremely vigorous and will get cut back after they bloom next Spring.
Best of luck with your garden!!
you need to start your own post...
and list the plants you are talking about ...
if you want some precise answers ...
in my experience.. flopping plants is due to over fertilization ... and i would discuss that in your new post ...
ps: june or july is WAY TOO LATE .... it would be now or april ... before new spring growth starts ....


text: I arrived yesterday about 1 pm. Sunny Skies temperature about 80. Villa not ready, so I grabbed a kids meal at Roaring forks and went out to ride the little boat around the Bay Lake loop. Twice. One of my favorite activities at the world. Checked phone. no signal! Oops. Went up to the lobby at 3, room just then ready - saw the housekeeper in the hall as I was walking to 1514, perfect requested location near the laundry room. (I have a mobility issue but no ecv for this leg of the trip, so requested ground floor close in) Room is in excellent shape. Sparkling clean and well stocked. Bedspread not only looked clean, it appeared to be new. This section still has the pinecone carpets, so I carefully took photos to preserve my memories of home as it was when we bought it. The main lobby has been slightly redecorated, with groupings of high back chairs upholstered in something that resembles "storm" pattern Navajo rugs. The most notable feature was the utter lack of people in view. Hidden Springs hot tub is closed, but the pool wasn't bad when I went for a dip last night. Up for sunrise this morning. Photo later. Wish you were here!

subset: commoncrawl


text:
Need some Aussie help, please
I know we can grow broms but what other plants do you have that can grow in South Florida?
One of my garden buddies needs help at her zoo and posted this on the Florida forum. Any help you could give would be most appreciated.
Thanks so much
Here is a link that might be useful: Original post on the Fla forum
Hi coffeemom,
I don't think Koalas eat bromeliads so I think you would be better asking members of the Garden Web Australia forum under "Australian native plants", or send an Email to Sydney's Taronga Park Zoo, they could better advise on suitable plants for Koalas because although they eat gum leaves, they only eat specific types.
Hope this helps,
Sorry everyone, I had to add the word bromeliads to make it all legal didn't I?
All the best, Nev.


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Story Trumps Structure: How to Write Unforgettable Fiction by Breaking the Rules
by Steven James
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Don't limit your fiction - LIBERATE IT
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Award-winning novelist Steven James explains how to trust the narrative process to make your story believable, compelling, and engaging, and debunks the common myths that hold writers back from creating their best work.
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Publications (52)184.83 Total impact
Article: Bongkrekic acid as a selective activator of the peroxisome proliferator-activated receptor γ (PPARγ) isoform.[Show abstract] [Hide abstract]
ABSTRACT: Bongkrekic acid (BKA), an antibiotic isolated from Pseudomonas cocovenans, is an inhibitory molecule of adenine nucleotide translocase. Since this translocase is a core component of the mitochondrial permeability transition pore (MPTP) formed by apoptotic stimuli, BKA has been used as a tool to abrogate apoptosis. However, the other biochemical properties of BKA have not yet been resolved. Although the definition of a fatty acid is a carboxylic acid (-COOH) with a long hydrocarbon chain (tail), when focused on the chemical structure of BKA, the molecule was revealed to be a branched unsaturated tricarboxylic acid that resembled the structure of polyunsaturated fatty acids (PUFAs). Peroxisome proliferator-activated receptors (PPARs) consist of a subfamily of three isoforms: α, β, and γ, the ligands of which include PUFAs. Using completely synthesized BKA together with simplified BKA derivatives (purity: > 98%), we herein demonstrated the utility of BKA as a selective activator of the human PPARγ isoform, which may not be associated with the anti-apoptotic nature of BKA. We also discussed the possible usefulness of BKA.The Journal of Toxicological Sciences 01/2015; 40(2):223-33. DOI:10.2131/jts.40.223 · 1.38 Impact Factor
Article: Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.[Show abstract] [Hide abstract]
ABSTRACT: We recently reported that 9-tetrahydrocannabinol (9-THC), a major cannabinoid component in Cannabis Sativa (marijuana), significantly stimulated the expression of fatty acid 2-hydroxylase (FA2H) in human breast cancer MDA-MB-231 cells. Peroxisome proliferator-activated receptor (PPAR) was previously implicated in this induction. However, the mechanisms mediating this induction have not been elucidated in detail. We performed a DNA microarray analysis of 9-THC-treated samples and showed the selective up-regulation of the PPAR isoform coupled with the induction of FA2H over the other isoforms ( and ). 9-THC itself had no binding/activation potential to/on PPAR, and palmitic acid (PA), a PPAR ligand, exhibited no stimulatory effects on FA2H in MDA-MB-231 cells; thus, we hypothesized that the levels of PPAR induced were involved in the 9-THC-mediated increase in FA2H. In support of this hypothesis, we herein demonstrated that i) 9-THC activated the basal transcriptional activity of PPAR in a concentration-dependent manner, ii) the concomitant up-regulation of PPAR/FA2H was caused by 9-THC, iii) PA could activate PPAR after the PPAR expression plasmid was introduced, and iv) the 9-THC-induced up-regulation of FA2H was further stimulated by the co-treatment with L-663,536 (a known PPAR inducer). Taken together, these results support the concept that the induced levels of PPAR may be involved in the 9-THC up-regulation of FA2H in MDA-MB-231 cells.Toxicology 10/2014; DOI:10.1016/j.tox.2014.09.011 · 3.75 Impact Factor
Article: Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells.[Show abstract] [Hide abstract]
ABSTRACT: Metastases are known to be responsible for approximately 90% of breast cancer-related deaths. Cyclooxygenase-2 (COX-2) is involved not only in inflammatory processes, but also in the metastasis of cancer cells; it is expressed in 40% of human invasive breast cancers. To comprehensively analyze the effects of cannabidiolic acid (CBDA), a selective COX-2 inhibitor found in the fiber-type cannabis plant (Takeda et al., 2008), on COX-2 expression and the genes involved in metastasis, we performed a DNA microarray analysis of human breast cancer MDA-MB-231 cells, which are invasive breast cancer cells that express high levels of COX-2, treated with CBDA for 48 hr at 25 µM. The results obtained revealed that COX-2 and Id-1, a positive regulator of breast cancer metastasis, were down-regulated (0.19-fold and 0.52-fold, respectively), while SHARP1 (or BHLHE41), a suppressor of breast cancer metastasis, was up-regulated (1.72-fold) and CHIP (or STUB1) was unaffected (1.03-fold). These changes were confirmed by real-time RT-PCR analyses. Taken together, the results obtained here demonstrated that i) CBDA had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and ii) CBDA may possess the ability to suppress genes that are positively involved in the metastasis of cancer cells in vitro.The Journal of Toxicological Sciences 01/2014; 39(5):711-6. DOI:10.2131/jts.39.711 · 1.38 Impact Factor
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ABSTRACT: Few studies have examined xanthocidin, a biotic isolated from Streptomyces xanthocidicus in 1966, because its supply is limited. Based on its chemical structure, xanthocidin has the potential to become a lead compound in the production of agrochemicals and anti-cancer drugs; however, it is unstable under both basic and acidic conditions. We recently established the total synthesis of xanthocidin using the FeCl3-mediated Nazarov reaction, and obtained two stable derivatives (#1 and #2). The results of the present study demonstrated that these derivatives exhibited the inhibitory activity of topoisomerase IIα, known as a molecular target for cancer chemotherapy, and this was attributed to the respective exo-methylene ketone group without DNA intercalation. The results obtained also suggest that these derivatives may have value as lead compounds in the synthesis of topoisomerase IIα inhibitors.Biological & Pharmaceutical Bulletin 01/2014; 37(2):331-4. DOI:10.1248/bpb.b13-00757 · 1.85 Impact Factor
Article: Δ(9)-Tetrahydrocannabinol Disrupts Estrogen-Signaling Through Up-regulation of Estrogen Receptor β (ERβ).[Show abstract] [Hide abstract]
ABSTRACT: Δ(9)-Tetrahydrocannabinol (Δ(9)-THC) has been reported as possessing anti-estrogenic activity, although the mechanisms underlying these effects are poorly delineated. In this study, we used the estrogen receptor α (ERα)-positive human breast cancer cell line, MCF-7, as an experimental model and show that Δ(9)-THC exposures markedly suppress 17β-estradiol (E2)- induced MCF-7 cell proliferation. We demonstrate that these effects result from Δ(9)-THC's ability to inhibit E2-liganded ERα activation. Mechanistically, the data obtained from biochemical analyses revealed that: i) Δ(9)-THC up-regulates ERβ, a repressor of ERα, inhibiting the expression of E2/ERα-regulated genes that promote cell growth, and that ii) Δ(9)-THC induction of ERβ modulates E2/ERα signaling in the absence of direct interaction with the E2 ligand binding site. Therefore, the data presented support the concept that Δ(9)-THC's anti-estrogenic activities are mediated by the ERβ disruption of E2/ERα signaling. ααααααααααChemical Research in Toxicology 05/2013; 26(7). DOI:10.1021/tx4000446 · 4.19 Impact Factor
Article: (-)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIα inhibition and reactive oxygen species.[Show abstract] [Hide abstract]
ABSTRACT: Previously, we reported that (-)-xanthatin, a naturally occurring xanthanolide present in the Cocklebur plant, exhibits potent anti-proliferative effects on human breast cancer cells, accompanied by an induction of the growth arrest and DNA damage-inducible gene 45γ (GADD45γ), recognized recently as a novel tumor suppressor gene. However, the mechanisms mediating this activation were unknown. Topoisomerase IIα (Topo IIα) inhibition has been reported to produce a cell death response accompanied by an atypical DNA laddering fragmentation profile, similar to that noted previously for (-)-xanthatin. Therefore we hypothesized that (-)-xanthatin's GADD45γ activation was mediated through the Topo IIα pathway. Here, we identify that (-)-xanthatin does function as a catalytic inhibitor of Topo IIα, promoting DNA damage. In addition, reactive oxygen species (ROS) were elevated in cells treated with this agent. Mechanistically, it was determined that the induced levels of GADD45γ mRNA resulting from (-)-xanthatin exposures were stabilized by coordinately produced ROS, and that the consequent induction of GADD45γ mRNA, GADD45γ protein and ROS generation were abrogated by co-treatment with N-acetyl-L-cysteine. Taken together, the data support the concept that Topo IIα inhibition by (-)-xanthatin is a trigger that stimulates expression of DNA damage-inducible GADD45γ mRNA and that concomitantly produced ROS act downstream to further enhance the GADD45γ mRNA/GADD45γ protein induction process, resulting in breast cancer cell death.Toxicology 01/2013; DOI:10.1016/j.tox.2012.12.019 · 3.75 Impact Factor
Article: Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells.[Show abstract] [Hide abstract]
ABSTRACT: To investigate gene(s) being regulated by ∆(9)-tetrahydrocannabinol (∆(9)-THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells, which are poorly differentiated breast cancer cells, treated with ∆(9)-THC for 48 hr at an IC50 concentration of approximately 25 µM. Among the highly up-regulated genes (> 10-fold) observed, fatty acid 2-hydroxylase (FA2H) was significantly induced (17.8-fold). Although the physiological role of FA2H has not yet been fully understood, FA2H has been shown to modulate cell differentiation. The results of Oil Red O staining after ∆(9)-THC exposure showed the distribution of lipid droplets (a sign of the differentiated phenotype) in cells. Taken together, the results obtained here indicate that FA2H is a novel ∆(9)-THC-regulated gene, and that ∆(9)-THC induces differentiation signal(s) in poorly differentiated MDA-MB-231 cells.The Journal of Toxicological Sciences 01/2013; 38(2):305-308. DOI:10.2131/jts.38.305 · 1.38 Impact Factor
Article: (-)-Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells.[Show abstract] [Hide abstract]
ABSTRACT: We reported that (-)-xanthatin, a xanthanolide sesquiterpene lactone present in the Cocklebur plant, exhibited potent anti-proliferative effects on human breast cancer cells, in which GADD45γ, a novel tumor suppressor gene, was induced. Mechanistically, topoisomerase IIα (Topo IIα) inhibition by (-)-xanthatin was shown to be the upstream trigger that stimulated the expression of GADD45γ mRNA and concomitantly produced reactive oxygen species (ROS) to maintain this expression. Since the anti-cancer drug etoposide, a selective Topo IIα inhibitor, has also been shown to induce intracellular ROS, (-)-xanthatin may exert its anti-proliferative effects on cancer cells in a similar manner to those of etoposide. In the present study, to generalize its applicability to cancer therapy, we further investigated the biological activities of (-)-xanthatin by comparing its activities to those of the established anti-cancer drug etoposide. After the exposure of breast cancer cells to (-)-xanthatin or etoposide, a prolonged and marked up-regulation in the expression of c-fos, a proapoptotic molecule, was detected together with GADD45γ; and the expression of these molecules was stabilized by ROS and abrogated by the pretreatment with N-acetyl-L-cysteine (NAC), a potent ROS scavenger. (-)-Xanthatin in particular exhibited stronger anti-proliferative potential than that of etoposide, which underlies the marked induction of c-fos/GADD45γ and ROS production.The Journal of Toxicological Sciences 01/2013; 38(4):547-57. DOI:10.2131/jts.38.547 · 1.38 Impact Factor
Article: Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration[Show abstract] [Hide abstract]
ABSTRACT: Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.Toxicology Letters 09/2012; 214(3):314-319. DOI:10.1016/j.toxlet.2012.08.029 · 3.36 Impact Factor
Article: Formation of repressor-inducer-operator ternary complex: negative cooperativity of d-camphor binding to CamR.[Show abstract] [Hide abstract]
ABSTRACT: A repressor composed of homodimeric subunits, as is often found in bacteria, possesses two effector-binding sites per molecule, enabling sophisticated regulation by the cooperative binding of two effector molecules. Positive cooperativity generates a narrower region of effector concentration for switching, but little is known about the role of negative cooperativity. d-camphor, an inducer for Pseudomonas putida cytochrome P450cam hydroxylase operon (camDCAB), binds to the homodimeric cam repressor (CamR). Here, we report solid evidence that the complex of CamR and an operator DNA is not dissociated by the first binding of d-camphor but, at a higher concentration, is dissociated by the second binding. d-camphor thus binds to the CamR in two steps with negative cooperativity, yielding two distinct dissociation constants of K(d1 ) =( ) 0.064 ± 0.030 and K(d2 ) =( ) 14 ± 0.3 μm, as well as the Hill coefficient of 0.56 ± 0.05 (<1). The first binding guarantees the high specificity of the inducer by the high affinity, although the second binding turns on the gene expression at a 200-fold higher concentration, a more suitable switching point for the catabolism of d-camphor.Genes to Cells 11/2011; 16(12):1200-7. DOI:10.1111/j.1365-2443.2011.01563.x · 2.73 Impact Factor
Article: (-)-Xanthatin Selectively Induces GADD45 gamma and Stimulates Caspase-Independent Cell Death in Human Breast Cancer MDA-MB-231 Cells[Show abstract] [Hide abstract]
ABSTRACT: exo-Methylene lactone group-containing compounds, such as (--)-xanthatin, are present in a large variety of biologically active natural products, including extracts of Xanthium strumarium (Cocklebur). These substances are reported to possess diverse functional activities, exhibiting anti-inflammatory, antimalarial, and anticancer potential. In this study, we synthesized six structurally related xanthanolides containing exo-methylene lactone moieties, including (--)-xanthatin and (+)-8-epi-xanthatin, and examined the effects of these chemically defined substances on the highly aggressive and farnesyltransferase inhibitor (FTI)-resistant MDA-MB-231 cancer cell line. The results obtained demonstrate that (--)-xanthatin was a highly effective inhibitor of MDA-MB-231 cell growth, inducing caspase-independent cell death, and that these effects were independent of FTase inhibition. Further, our results show that among the GADD45 isoforms, GADD45γ was selectively induced by (--)-xanthatin and that GADD45γ-primed JNK and p38 signaling pathways are, at least in part, involved in mediating the growth inhibition and potential anticancer activities of this agent. Given that GADD45γ is becoming increasingly recognized for its tumor suppressor function, the results presented here suggest the novel possibility that (--)-xanthatin may have therapeutic value as a selective inducer of GADD45γ in human cancer cells, in particular in FTI-resistant aggressive breast cancers.Chemical Research in Toxicology 06/2011; 24(6):855-65. DOI:10.1021/tx200046s · 4.19 Impact Factor
Article: Δ9-tetrahydrocannabinol and its major metabolite Δ9-tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors[Show abstract] [Hide abstract]
ABSTRACT: 15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein, a major causal factor for atherosclerosis. Δ(9)-Tetrahydrocannabinol (Δ(9)-THC), a major component of marijuana, has suggested to suppress atherosclerosis. Although Δ(9)-THC seems to be attractive for the prevention of atherosclerosis, there is no information about whether or not 15-LOX isoform can be inhibited by Δ(9)-THC. In the present study, Δ(9)-THC was found to be a direct inhibitor for 15-LOX with an IC(50) (50% inhibition concentration) value of 2.42 μM. Furthermore, Δ(9)-THC-11-oic acid, a major and nonpsychoactive metabolite of Δ(9) -THC, but not another Δ(9)-THC metabolite 11-OH-Δ(9)-THC (psychoactive), was revealed to inhibit 15-LOX. Taken together, it is suggested that Δ(9) -THC can abrogate atherosclerosis via direct inhibition of 15-LOX, and that Δ(9)-THC-11-oic acid is shown to be an "active metabolite" of Δ(9) -THC in this case.Journal of Pharmaceutical Sciences 03/2011; 100(3):1206-11. DOI:10.1002/jps.22354 · 3.13 Impact Factor
Article: Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro.[Show abstract] [Hide abstract]
ABSTRACT: 15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein (ox-LDL), a major causal factor for atherosclerosis. Both enzymatic (15-LOX) and non-enzymatic (Cu(2+)) mechanisms have been proposed for the production of ox-LDL. We have recently reported that cannabidiol-2',6'-dimethyl ether (CBDD) is a selective and potent inhibitor of 15-LOX-catalyzed linoleic acid oxygenation (Takeda et al., Drug Metab. Dispos., 37, 1733-1737 (2009)). In the LDL, linoleic acid is present as cholesteryl linoleate, the major fatty acid esterified to cholesterol, and is susceptible to oxidative modification by 15-LOX or Cu(2+). In this investigation, we examined the efficacy of CBDD on i) 15-LOX-catalyzed oxygenation of cholesteryl linoleate, and ii) ox-LDL formation catalyzed by 15-LOX versus Cu(2+)-mediated non-enzymatic generation of this important mediator. The results obtained demonstrate that CBDD is a potent and selective inhibitor of ox-LDL formation generated by the 15-LOX pathway. These studies establish CBDD as both an important experimental tool for characterizing 15-LOX-mediated ox-LDL formation, and as a potentially useful therapeutic agent for treatment of atherosclerosis.Biological & Pharmaceutical Bulletin 01/2011; 34(8):1252-6. DOI:10.1248/bpb.34.1252 · 1.85 Impact Factor
Article: Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride.[Show abstract] [Hide abstract]
ABSTRACT: In clinical practice, glucocorticoids are often used with the aim of modulating the efficacy and toxicity of chemotherapeutic agents. However, how glucocorticoids modulate the pharmacological action of chemotherapeutic agents remains to be clarified. In this study, we generated glucocorticoid receptor (GR)-deficient rat-1 cells to investigate the role of GR in the regulation of cellular sensitivity to irinotecan hydrochloride (CPT-11). Treatment of wild-type rat-1 cells with dexamethasone (DEX) significantly enhanced the cytotoxic effect of CPT-11, whereas the treatment had little effect on the cytotoxicity of CPT-11 in GR-deficient cells. Topoisomerase-I activity in wild-type cells after concomitant treatment with DEX and CPT-11 was significantly lower than that after treatment with CPT-11 alone. DEX treatment also enhanced the inhibitory action of CPT-11 on the phosphatidylinositol 3-kinase-Akt signaling pathway in wild-type cells, accompanied by facilitating caspase-3 activity. These modulatory effects of DEX on the CPT-11-induced cytotoxicity were not observed in GR-deficient cells. Our present findings reveal the underlying mechanism by which GCs enhance the chemotherapeutic effect of CPT-11 and indicate the possibility that the dosage of CPT-11 could be reduced by the combination treatment with GCs, which may attenuate the adverse effect without decreasing anti-tumor activity.Journal of Pharmacological Sciences 03/2009; 109(2):265-74. DOI:10.1254/jphs.08219FP · 2.11 Impact Factor
Article: Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function.[Show abstract] [Hide abstract]
ABSTRACT: Altered homeostatic regulation, including the disturbance of circadian rhythms, is often observed in patients undergoing interferon (IFN) therapy. We reported previously that IFN-alpha has the ability to modulate the circadian clock function at the molecular level and that the alteration of clock function could be overcome by changing the dosing schedule. In this study, we investigated the influence of IFN-alpha on the intrinsic biological rhythms in mice by comparing two dosing schedules, continuous administration and repetitive injection. Continuous administration of IFN-alpha to mice decreased the rhythm amplitude of locomotor activity, body temperature, leukocyte counts, and plasma corticosterone levels. The treatment also suppressed the oscillation in the expression of clock genes in the liver. On the other hand, modulation effects were scarcely observed in mice treated with repetitive injection of IFN-alpha. These results indicate that treatment with IFN-alpha does not always modulate the circadian clock function. This notion was also supported by in vitro findings that the inhibitory action of IFN-alpha on the expression of clock genes was dependent on its exposure time to cells. The alteration of clock function induced by IFN-alpha could be avoided by optimizing the dosing schedule.Life Sciences 10/2008; · 2.30 Impact Factor
Article: Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function[Show abstract] [Hide abstract]
ABSTRACT: Altered homeostatic regulation, including the disturbance of circadian rhythms, is often observed in patients undergoing interferon (IFN) therapy. We reported previously that IFN-alpha has the ability to modulate the circadian clock function at the molecular level and that the alteration of clock function could be overcome by changing the dosing schedule. In this study, we investigated the influence of IFN-alpha on the intrinsic biological rhythms in mice by comparing two dosing schedules, continuous administration and repetitive injection. Continuous administration of IFN-alpha to mice decreased the rhythm amplitude of locomotor activity, body temperature, leukocyte counts, and plasma corticosterone levels. The treatment also suppressed the oscillation in the expression of clock genes in the liver. On the other hand, modulation effects were scarcely observed in mice treated with repetitive injection of IFN-alpha. These results indicate that treatment with IFN-alpha does not always modulate the circadian clock function. This notion was also supported by in vitro findings that the inhibitory action of IFN-alpha on the expression of clock genes was dependent on its exposure time to cells. The alteration of clock function induced by IFN-alpha could be avoided by optimizing the dosing schedule.Life Sciences 09/2008; 83(15-16):574-80. DOI:10.1016/j.lfs.2008.08.005 · 2.30 Impact Factor
Article: Transcription regulation by feast/famine regulatory proteins, FFRPs, in archaea and eubacteria.[Show abstract] [Hide abstract]
ABSTRACT: Feast/famine regulatory proteins (FFRPs) comprise a single group of transcription factors systematically distributed throughout archaea and eubacteria. In the eubacterial domain in Escherichia coli, autotrophic pathways are activated and heterotrophic pathways are repressed by an FFRP, the leucine-responsive regulatory protein (Lrp), in some cases in interaction with other transcription factors. By sensing the concentration of leucine, Lrp changes its association state between hexadecamers and octamers to adapt the autotrophic or heterotrophic mode. The lrp gene is regulated so that the concentration of Lrp decreases in the presence of rich nutrition. In the archaeal domain a large part of the metabolism of Pyrococcus OT3 is regulated by another FFRP, FL11. In the presence of rich nutrition, the metabolism is released from repression by FL11; transcription of fl11 is terminated by FL11 forming octamers in interaction with lysine. When the nutrient is depleted, the metabolism is arrested by a high concentration of FL11; FL11 disassembles to dimers in the absence of lysine, and repression of transcription of fl11 is relaxed. Common characteristics of the master regulations by FL11 and Lrp hint at the prototype regulation once achieved in the common ancestor of all extant organisms. Mechanisms of discrimination by FFRPs between DNA sequences and also between co-regulatory molecules, mostly amino acids, and variations of transcription regulations observed with archaea and eubacteria are reviewed.Biological & Pharmaceutical Bulletin 03/2008; 31(2):173-86. DOI:10.1248/bpb.31.173 · 1.78 Impact Factor
Article: Dosing schedule-dependent change in the disruptive effects of interferon-α on the circadian clock function[Show abstract] [Hide abstract]
ABSTRACT: Altered homeostatic regulation, including the disturbance of circadian rhythms, is often observed in patients undergoing interferon (IFN) therapy. We reported previously that IFN-α has the ability to modulate the circadian clock function at the molecular level and that the alteration of clock function could be overcome by changing the dosing schedule. In this study, we investigated the influence of IFN-α on the intrinsic biological rhythms in mice by comparing two dosing schedules, continuous administration and repetitive injection. Continuous administration of IFN-α to mice decreased the rhythm amplitude of locomotor activity, body temperature, leukocyte counts, and plasma corticosterone levels. The treatment also suppressed the oscillation in the expression of clock genes in the liver. On the other hand, modulation effects were scarcely observed in mice treated with repetitive injection of IFN-α. These results indicate that treatment with IFN-α does not always modulate the circadian clock function. This notion was also supported by in vitro findings that the inhibitory action of IFN-α on the expression of clock genes was dependent on its exposure time to cells. The alteration of clock function induced by IFN-α could be avoided by optimizing the dosing schedule.
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ABSTRACT: Because a variety of receptor tyrosine kinases are involved in the mechanism of tumor progression, the development of a clinically useful tyrosine kinase inhibitor is expected as a therapeutic agent for the treatment of malignant cancers. Imatinib mesylate, known as Gleevec or STI-571, is a molecule that inhibits the function of various receptors with tyrosine kinase activity, such as Abl, the bcr-abl chimeric product, KIT, and platelet-derived growth factor (PDGF) receptors. In this study, we investigated the influence of dosing time on the ability of imatinib to inhibit tumor growth in mice. Tumor-bearing mice were housed under standardized light/dark cycle conditions (lights on at 07:00 h, off at 19:00 h) with food and water ad libitum. The growth of tumor cells implanted in mice was more severely inhibited by the administration of imatinib (50 mg/kg, i.p.) in the early light phase than when it was administered in the early dark phase. The dosing time-dependency of anti-tumor effects was parallel to that of imatinib-induced anti-angiogenic effect. The inhibitory effect of imatinib on tyrosine kinase activity of PDGF receptors, but not of KIT and Abl, varied according to its administration time. The dosing time-dependency of imatinib-induced inhibition of PDGF receptor activity was closely related to that of its anti-tumor effects. Our results suggest that the anti-tumor efficacy of imatinib is enhanced by administering the drug when PDGF receptor activity was increased. The potent therapeutic efficacy of the drug could be expected by optimizing the dosing schedule.Biochemical Pharmacology 12/2006; 72(10):1237-45. DOI:10.1016/j.bcp.2006.08.002 · 4.65 Impact Factor
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ABSTRACT: The expression of the exotoxin A gene (toxA) in Pseudomonas aeruginosa is a complicated process that involves several regulators, including ptxR, which enhances toxA expression by 4- to 5-fold. Available evidence suggests that ptxR is expressed from two separate promoters, P1 and P2. Previous evidence indicated the presence, within the ptxR upstream region, of binding sites for several regulatory proteins, including PtxS, which negatively regulates ptxR expression. We utilized nested deletion and in vitro transcription analyses to examine the regulation of ptxR expression. The results from nested deletion analysis suggest that under aerobic conditions in iron-deficient medium, ptxR expression follows a biphasic curve that involves the P1 promoter only. Iron eliminated the second peak of ptxR expression but did not affect expression from the P2 promoter. Under microaerobic conditions, iron represses ptxR expression from subclones that carry P1 alone or P2 alone at both early and late stages of growth. Under anaerobic conditions, ptxR expression increases considerably. In addition, our results suggest that different segments of the ptxR upstream region play specific roles in ptxR expression; their deletion caused variations in the level as well as the pattern of ptxR expression. Our results also indicate that negative regulation of ptxR expression by PtxS does not occur through the PtxS binding site within the ptxR-ptxS intergenic region. In vitro transcription analysis using sigma70-reconstituted P. aeruginosa RNA polymerase produced one transcript that closely resembles T1, indicating that P1 is recognized by sigma70. RNA polymerase reconstituted with either RpoS or AlgU produced no transcripts. However, a transcript was produced by RpoH-reconstituted RNA polymerase.Canadian Journal of Microbiology 05/2006; 52(4):343-56. DOI:10.1139/w05-138 · 1.18 Impact Factor
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DEFINITION of 'Allocation Rate'
The percentage of an investor's initial cash or capital outlay that actually goes toward the final investment. This amount is net of any fees that may be incurred upon initial investment and is effectively the amount that is exposed to the investment.
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For example, if a mutual fund carries a 4% front-end load, only 96% of an investor's initial investment will actually be placed into the fund itself, with the rest going to the investment company. The higher the fees, the lower the overall allocation rate will be for the investor.
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CommissionA service charge assessed by a broker or investment advisor in ...
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Monday, 30 March 2015
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Feb 13 2012 | 7:32am ET
Paris-based Bryan Garnier Asset Management has hired former StormHarbour Alternative Investments employee Epiphanios Michael as manager for it European equities long/short fund.
Michael will have full responsibility for investment and research on the Leadership en Actions Fund.
Michael was an analyst on European stocks at London-based StormHarbour until February 2012. Prior to that he spent two years with Macquarie Capital Partners as a corporate finance analyst and from 2006 to 2009 was an analyst covering Asian stocks at Prodigy Capital Partners (long/short Asia Fund) in London.
Said Vania Mareuse, BGAM managing partner, in a statement: "We at BGAM are extremely happy that Epi is joining us at this stage of growth in our business and welcome him as a key member of the fund management team."
Michael said he intends to use his "top-down economic/industry themes to uncover public equities that face significant shifts in earnings, both positive and negative. This strategy has served me well as a hedge fund analyst over the past several years, especially in 2011, and there continue to be significant opportunities in Europe where structural imbalances amongst countries and industries continue."
BGAM is part of Bryan Garnier & Co, a privately owned European Investment bank focused on European Growth companies, with offices in Paris, London, New York, Geneva and New Dehli.
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StreetWise Partners, a non-profit organization that works with low-income individuals to help them overcome employment barriers, raised over $275,000 at the 2015 Raising the Ante Charity Poker Tournament and Casino Event last Wednesday evening at Capitale. Here are some photos from the event. Read more…


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["aerosol","ammunition","arbalest","arms","arrow","axe","blockhead","blue","bomb","bow","button","buttons","cartridge","club","crossbow","cudgel","dagger","defense","dynamite","explosive","fire","firearm","fist","gas","grenade","gun","hand","icon","icons","knife","patron","pictogram","pictograms","pistol","revolver","rifle","self","selfdefense","set","shield","sign","signs","sword","symbol","symbols","target","tommy","vector","weapon","web"]aerosol ammunition arbalest arms arrow axe blockhead blue bomb bow button buttons cartridge club crossbow cudgel dagger defense dynamite explosive fire firearm fist gas grenade gun hand icon icons knife patron pictogram pictograms pistol revolver rifle self selfdefense set shield sign signs sword symbol symbols target tommy vector weapon web See all keywords
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kousa dogwood (korean) fruit edible?
Some articles on the web about korean dogwoods stated that the fruits are edible. Are they really safe to eat? Has anyone tried them? Do they contain any vitamins? Thanks!
I pulled a couple off a tree about two weeks ago. To the chagrin of my wife I tore one open and tasted it. Sweet, but not much to enjoy (I didn't attempt to eat the whole fruit). Given their size I don't think I would personally devote space to them.
Sorry I couldn't tell you more.
You don't want to eat the whole fruit - the skin is gritty and disagreeable. Just tear 'em open and massage/suck the pulp into your mouth.
They're OK in small numbers, but I wouldn't want to sit down and eat a whole bunch of them at one sitting.
I've had one friend who indicated that he experienced a 'racing heartbeat'(tachycardia?) following eating Kousa fruits, but it's never been a problem for me.
Agreed, I wouldn't plant 'em just for fruit production, but they are a very nice ornamental, and the edible fruit is an added benefit.
Could I mash a mass-selection of fruits (I have 4 trees in my yard) into a sort of juice or what have you?
Also...Im no environmental horticulturalist nor a tree expert...but if I were to plant a few of the fruits, what would I get? Would it be likely for another tree to spring up? Thanks for you time.
Hi all, as far as I know, all cornus sp. bear edible fruits, some more tasty than others. Cornus mas (cornelian cherry) is the one usually grown for fruit,but over here in cooler parts of the country they grow cornus kousa var. chinensis for fruit, many say they have a taste reminiscent of strawberries. All the best from Aus!
OK I'm no botanist- a physician yes, a homo sapiens sapiens yes- but one renting a house near Mystic, CT. A house which boasts a large south-facing kousa dogwood in the yard this sunny 9/16/08 and covered with red succulent raspberry-resembling fruit just as depicted in the appended link to a Wiki jpeg. Inspired by this and other threads I gave in to the siren song of these lovely red berries and sampled...and then gorged myself on their delicious contents, free for the taking.
The horny encasements which so resemble ripe raspberries from a distance are, in fact, tough camouflage but therefore lend themselves perfectly to a simple extraction of the contained delight: a gentle squeeze at the apex bursts the stem end off and empties the yellow-orange slimy pulp into your hand. Toss this into your gob and then and let your tongue savor the complexity of topical flavors: the unequivocally sweet mango-and-butternut-squash admixed essence, before you separate out the 3-4 hard inedible seeds that you must inconspicuously expectorate to their natural destination of turf, prior to swallowing the small aliquot that remains of the ambrosia so easily harvested from any single easily-accessible fruit - all gratis, at no cost, and for free. Then notice that there remain for your convenience innumerable berries: plenty enough on a single mature Kousa to sate an army of starving gluttons. For some reason ignored by the usual opportunists, perhaps intrinsically resistant to attack by any parasites or mange so that every fruit is perfectly formed- unsullied and provided for your convenient pleasure as if by Eden's bounty.
No tachycardia nor toxicity - just a charming free lunch, courtesy of Providence -and for no apparent reason- one which is as yet undiscovered by the world at large, as improbable as chancing upon the strawberry plant in a world where strawberries have never been noticed to be edible.
Dogwoods can and do bear fruit: I really like them!
Here is a link that might be useful:
I made a jam from my mother's tree. It smelled a bit like a nectarine or apricot to me. It was very easy to jam as once the fruit was expelled, it had the consistency of baby food apricots. Since they do not ripen all at once, I plan to go back and get more.
I too have made jam out of the Kousa fruits. It has quite a pleasant flavor but in making the jam the gritty cells from the skin mix with the pulp and made for a "sandy" jam. Next time I'll strain the juice through a jelly bag so as to eliminate the sandy texture.
I experiment with jams and jellies all the time with obscure fruits. Most turn out quite nicely, occasionally there are flops...Oh well!
I worked a landscape nursery and sampled fruit from all the trees we had one fall. They varied in size and taste. Not surprising, since they are usually selected for flower, not fruit. Some weren't worth seconds, but the better ones were quite nice. Kind of a tropical taste, in my opinion. You must discard the exterior, though.
I hope to get several when budget allows. They're attractive and the fruit is a bonus.
Many years ago, I remember reading an article that warned against eating any part of dogwood trees. I'm sure the trees that were referred to were Cornus Florida, the common native dogwood, since the Kousa form was very rare back then (around 1960). The article reported that some boy scouts had become sick after using the branches to hold hot dogs over a fire. They had peeled off the bark, and the sap was said to be so poisonous that two of the scouts had died. In recent years, my two dogs have discovered the fruit of my large Cornus kousa Chinensis. They gorge themselves on the fruit, spitting out the skins and seeds. At first, I used to rake up the fruit to keep it out of their reach thinking that it was probably poisonous. I kept thinking of the unfortunate boy scouts that I had read about many years earlier. For the past few years I've begun to just let the dogs eat the fruit since they don't seem to have suffered any ill effects. After reading several web postings, both here and elsewhere, I've decided to sample some this year when they ripen. I now have about a dozen of these beautiful trees on my property since I transplanted "volunteers" to suitable locations. The trees grow amazingly fast, especially when they're young, and I've even sold several of them. Anyway, in answer to your question, my dogs good health is testament to the safety of eating these strange fruits.
They are delicious! But note, you cannot eat more than 15 or so before becoming adverse to them. Pick the squishiest, almost rotten ones and squeeze into your mouth. Mmmmmm! Severely rotten ones will taste like the smell of gasoline, and if you have the right ones (you will know the difference after picking for a while), they taste tropical. Not too sugary, and just a tad bland enough to have you seeking more for the tropical taste.
I suggest Cornus Kousa 'Samaritain'.


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*Top 100 of 2012* Striking, rich and opulent, elegant and refined, with ripe, dense blackberry, melted black licorice and touches of cinnamon and baking spice. Ends with fine-grained, detailed tannins. Best from 2013 through 2027.
(12/ 2012)
Estate vineyards on hillside and valley floor sites of the Wooden Valley district of Napa Valley comprise Altamura's Cabernet Sauvignon. Altamura is the only winery in Wooden Valley. The dry-farmed vines were planted in 1986, and the wine was aged for 34 months in 70% new French oak.
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Syrian Media Declares 'Historic American Retreat'
Originally published on Sun September 1, 2013 9:09 am
Syrian state media on Sunday reacted to President Obama's decision to ask Congress for authorization to strike President Bashar al-Assad's regime, calling the move the start of a U.S. retreat.
"Whether the Congress gives the red or green light for an aggression, and whether the prospects of war have been enhanced or faded, President Obama has announced yesterday, by prevaricating or hinting, the start of the historic American retreat," Al-Thawra said.
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Apparently weary of the long British involvement in Iraq, the House of Commons issued Prime Minister David Cameron a stinging defeat last week when it voted not to sign on with Washington in a military strike on Syria.
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"The Syrian Coalition believes any possible military action should be carried out in conjunction with an effort to arm the Free Syrian Army. This will be vital in restraining Assad and ending the killing," the coalition said in a statement.


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I don't know if you can call losing those 5 players a meltdown. It's not like Hoke had them and then pissed them off or something. They committed to the school they felt best for them.
And had Isaac committed to UM, Green might not have.
I don't know if you can call losing those 5 players a meltdown. It's not like Hoke had them and then pissed them off or something. They committed to the school they felt best for them.
And had Isaac committed to UM, Green might not have.
Yeah I should have clarified that by saying the 5 biggest player Mgoblog meltdown under Hoke. Not saying its bad becuz obviously things happen for a reason. Green instead of Isaac, Kruger instead of Kozan, Kalis and any of our olineman instead of Diamond and Garnett and Harris instead of Treadwell.
I like every single one of our options there.
I'd say Garnett is the biggest one. Even Pip was upset he didn't go to Michigan, he acted like Garnett told him he was Blue or something.
I've read on other UM sites that David Shaw told Garnett that Hoke was leaving UM soon and that was helped push Garnett to Stanford. Supposedly, Peppers was initially not high on UM, despite being his childhood favorite, for the same reason: someone (quite possibly Shaw) told him that Hoke was bolting for the NFL.
Add in Shaw's recent douche-baggery on Twitter re: UM's academics not "measuring up" to Stanford's when tweeting to Peppers and Shaw is starting to climb his way up the "Douche-o-meter" scale of CFB coaches.
Knowing what we know now, I think the only ones I'd really still want are Isaac and Garnett. Not that they're guys we need, just that they're guys that I'd still be happy to take. The others have a few...questions...around them.
Didn't Countess originally commit to RR and maintain his committment after the coaching transition?
Yes, but the Countess re-recruitment was the first indication that Brady Hoke was pretty good at getting kids to be interested in Michigan.
is an effort in futility because there are so many players to choose from, nice problem to have, I say.
My personal top 5:
1: Green
2. Peppers
3. Pipkins
4. Kalis
5. Harris/Morris
In my opinion
1. Jabrill Peppers
2. Kyle Kalis
3. Derrick Green
4. Bryan Mone (Everything about this kid screams superstar to me.. Maybe a bias that I can't locate)
5. Drake Harris
I love Shane Morris as a prospect, but his performance just hasn't lined up w/ his rankings yet... I think Wilton will compete with Shane tooth and nail, too.. I think Pipkins is close at #5, but I think Harris is a definite need for a MNC run...
I think Morris has lived up to his ranking. He was great at The Opening. He only really had one bad performance at the AA game. I guess one bad performance is all it takes to go from a 5 star to a 4 star.
Actually, the most important performances are his actual high school games and in that regard Morris hasn't lived up to the hype. His stats from both his junior and senior seasons (I know he had mono as a senior, of course) were NOT impressive. Morris has mostly been hyped because of his tremendous arm strength...and that is pretty much it.
Except for his recruiting fervor, Morris wouldn't make my Top 10 list. Obviously, I hope he proves me wrong, but I am not expecting great things from Morris on the field. I'm not all that high on Speight, either. It seems like UM is trying to build a team that is NOT QB-centric a la Alabama: great OL, great RB, great defense, game manager QB.
Hoke and Borges coached Ryan Lindley at SDSU, who was very similar to Morris in arm strength, also had a gunslinger mentality and built similarly in stature. He turned into a good college QB and was drafted into the NFL. Don't give up on Morris yet until he gets some coaching. For all we know, his coaches or offensive system in high school may not have done him any favors.
As I'm sure Hoke would say...
1. The next guy
2. The guy after that
3. The guy after that
4. The guy after that
5. The guy after that...
Never rest on your laurels, it only gets you in trouble.
You'd do Jonny Falk proud. He favorite ring is always "the next one."
I think the OP was asking to grade players based on their performance as high school players and t heir recruiting hype/ranking/profile, not how they grade as college players. I say that because there were a lot of posts early on giving the OP grief about some of these kids not even being on campus yet.
For me I think it would be hard to put anyone ahead of Peppers given that he is probably the highest ranked kid UM has ever got, not just in the Hoke era, but any era.I mean, I know we all want Shane Morris to be a stud QB, but he wasn't even top two at his position, let alone top two overall in the country. For me the list would be:
1) Peppers
2) Green
3) Thomas
4) Kalis
5) Harris
Of course if he picks up Hand than he would take over top spot and everyone would slide down a spot. I don't see any other recruit that we are currently in could position with that could change that list..there are a few long shots, but none that are being predicted to come our way.
1. Morris
2. Peppers
3. Harris
4. Kalis
5. Green
According to my TTB Ratings...
1. Jabrill Peppers
2. Derrick Green/Kyle Kalis
4. James Ross III
5. Drake Harris
6. Ondre Pipkins
7. Dymonte Thomas
8. Joe Bolden/Kyle Bosch/Jarrod Wilson
That James Ross ranks so highly too.
You can't help to get excited with the possibility of all of those players being on the same field with each other next year.
1. Green
2. Peppers
3. Kalis
4. Pipkins
5. Harris
Honorable Mention: datbull4life
And how it was kind of a big deal, because the Wolverines had never signed a No. 1 tailback in the modern recruiting era?
When did the modern era start? Justin Fargas was the #1-ranked tailback in 1998.
He was an All American, and even wiki says Prep Football Report had him as the #2 running back. So someone probably had him as #1.
But that year with Fargas, Henson, Walker, and Terrell certainly had the #1 overall player among them.
And Tyrone Wheatley was one of the highest ranked kids recruited .... ever, period.
The #1 overall recruit that year was Ronald Curry, who went to UNC as a QB. All the guys you mentioned were in the top 10-15, though.
in Justin Fargas, arguably the no. 1 rated qb in Henson - always mentioned in top 5 - and for the first time since they've been keeping track we had 2 of the top 15 wrs in DT and AA. That has happened since, but this was the first. No, DT was not rated no. 1. ^Remember please I cannot get para breaks on this page so the ^ takes its place......sorry. I think the first three are ez to name in Green, Peppers and Kalis. I think Charlton will blow up. His lower body is just about identical to Kalis's and that is saying a lot. No one will push these two kids around. I think I will fence set on no. 5 and say one of the lber hauls in the last two classes will fill in the top five. ^Inasmuch as these things never turn out as predicted, i.e., Fargas, Grady, certainly an answer to a future trivia question such as, "Name the only 5* player-probably in any sport, in any league whose brother put up better stats in same sport as a walk-on, although he was recruited himself in another sport?" If not, it should be. ^ I think, although probably not as much fun because it gives us time to do some of our best guess work is naming the players who outplayed their status coming in. Top three on my list in the very recent past would have to be Hart, although given a 4th star at cb the moment he pledged to M, but recruited as a 3* runner, Jake Long and, of course, our most exciting offensive player ever, Denard Robinson. I'm guessing even those who can remember our first Heisman winner would have to give him the nod, although Tom definitely did more than DR as punter, passer, runner, receiver, etc. Then again, oh let's leave it there.....................
I've watched Shane Morris in high school and he is really good. Don't let the Sparties and Bucknutters get to you. He may not be Peppers good but he's still good.
TACO CHARLTON.... nobody mentioned him yet... he stole him from Ohio.... wait and see.... a year from now it'll be apparent that he belongs in the top 5 at this juncture.
From a production aspect, I'd say Matt Wile is #1.
In terms of on-field performance, probably Ross or Funchess. Norfleet maybe if they let him loose. Also, I'm higher on Pipkins than some people are just because big guys like that take time to develop and he hasnt embarrassed himself out there. As for the new guys, Morris, Peppers and Green are the biggest upside guys I see right now, with Harris one notch below along with Cole, who really feels like on of those dominant guards who you don't realize has been blowing guys off the line until you look at the rushing numbers.
I haven't read below, but mine are:
1. Jabrill Peppers
2. Kyle Kalis
3. Derrick Green
4. James Ross
5. David Dawson
his respective team to the top. His recruiting here, nonetheless, borders on spectacular. I have been watching M fb since Bo's first year, and I can't recall a consecutive three year period to match this. * Kalis is great and belongs among the top five. However, the fact that he had committed to OSU when many of them stayed makes his decision to move even more dramatic. I think, although he's rathed lower Marshall's commitment was significant as well. He was pretty much penciled in as going to EL by virtually all the recruiting gurus and one visit later, he pulls the plug. I'll stick with my five, and it didn't include Lawrence, but recruits of this nature are extremely significant because of the message it sends to those that thought they had the kids locked up. Surround the lesser recruited players with all these h.s. AAs and suddenly they have something to prove and many of them do. He's got a good system and once he got to a great school it didn't take long to see how it works.


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Officials question how waste pit was put near water
ROSS — Officials in Mountrail County say state regulators "dropped the ball" when a field inspector approved an oilfield waste pit too close to the water well for the city of Ross.
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Why ivy?
Watching "Fixer Upper" on HGTV. The house they are working on has a lot of damage & rodent infestation from ivy growth on the side of the house.
Other than the concept that it looks "charming," is there any real reason why any home owner would plant ivy to grow up a trellis (or side) on the house? In the past, did it keep homes cooler, or... something?
Just trying to figure out what the original purpose of ivy-covered English or New England homes might have been.
Maybe this will help answer your q...
Here is a link that might be useful: Ivy report
This is a topic near and not-so-dear to my heart. Before I bought my house at some point it was covered with ivy. It is a brick house. The ivy still grows on the ground around it and I am constantly battling it. I keep it off the walls and out of the lawn. I also have to cut it back from the AC condenser.
My garage backs up to my neighbor and they did not keep the ivy trimmed, so it grew up the wall and onto the roof. I had to climb on the roof and cut it back to keep it from getting under the shingles. Finally the house was empty for a short while so I went over and pulled down all the ivy. It took the top layer of stucco with it! Then I put weed killer all over it. Now I go over periodically to beat it back.
I had to have all the mortar between the bricks repointed due to the ivy damage, a huge expense.
I think the stuff is a scourge, right up there with creeping bamboo. It destroys the walls and provides a nice ladder for all kinds of bugs and rodents to get in your house.
I have slovenly neighbors across from me who rarely cut back the ivy on the house. Right now it completely covers the front, has grown over the screens and into the gutters.
On the other hand, there are some big old homes near me that loo quite handsome with the ivy on them. Nevertheless, I think underneath the house is being eaten alive.
I can't think of even one reason to let ivy grow on a house other than the charm, if you see it that way.
Obviously depends on the kind of ivy (as Annie's article points out) as well as the type of siding material on the building.
My house has cedar clapboard siding, so I make sure ivy is kept at bay from the house.
On the other hand, I'm trying to grow it up the walls of my outdoor shower as a privacy screen.
I'm allowing Boston ivy to cover my house. The siding is green asphalt and the ivy is giving the hse some character.
It's not anywhere as destructive as Hedera(English) and can be simply pulled off if I tire of it.
I'm even allowing it to grow across/cover a couple of east window, I love how the leaves filter the morning sun and the silhouettes created which I can enjoy from the inside.
Also a plus, in the fall it turns colors like a tree and then later drops its leaves.


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this girl is fucking beautiful... just wished she showed some skin...
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bored.. n runnin outta shit to post.
damn bro, source on this?
That scene is from the HK movie Lan Kwai Fong. The girl in the pic is named Dada Chan.
I purchased a bootleg version in Chinatown a few months ago for $3.00. The movie isn't great and kinda stale but who can complain when I got it for dirt cheap anyway. Besides I didn't really care for the storyline, I was only interested in the actresses that were in the film.
The sex scenes were pretty shitty and there is actually no nudity in the film what's so ever only some foreplay here and there. Some scenes are worth seeing tho if you can find it on the net.


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Scientific perspectives on drug and addiction research and news.
Drug Use and Violence: An Unhappy Relationship
The NIDA Blog Team
March 26, 2015
Research shows that girls are more likely than boys to experience dating violence, and that prescription drug use can contribute to the violence. More research is needed to learn how different drugs may make us more or less aggressive or more likely to be the victim of someone else who is using drugs or alcohol. Read More »3 Comments
Smokin' Hot Science
June 25, 2010
Did you ever wonder how scientists develop medications to help people stop smoking? High School Junior Ameya Deshmukh has been wondering about that since he was 7 years old. Because his parents work in science labs, he began learning about basic science from an early age. Read More »7 Comments
Alco-Pops: A Refreshment to Rethink
June 22, 2010
Alcohol companies have tapped into a growing market to introduce underage drinkers to their products, on the basis that kids who acquire a taste for alcoholic drinks early are more likely to get hooked. Read More »12 Comments
Virtual Brain Training
June 17, 2010
Imagine you are a teen with ADHD. It's hard for you to focus in class, your mind wanders everywhere, and even though you want to do well in class you'd much rather be outside shooting hoops. Although you take notes, it's hard for you to remember the teacher's instructions. Read More »16 Comments
Risky Business
June 15, 2010
Have you ever cut class? If so, what goes through your mind…how do you tell yourself it's ok? And what would discourage you from doing it? Read More »5 Comments
Real Teens Ask: What Are Opioids?
June 07, 2010
Teens have a lot of questions about drugs, which is why NIDA holds an annual Drug Facts Chat Day to explain the science behind drug abuse. Read More »22 Comments


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Russia: A 1,000 Year Chronicle of the Wild EastPaperback
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- Publication date: 31 December 2013
- Illustrations note: black & white illustrations, maps, black & white plates, colour plates
- Sales rank: 967,897
Product description
Combining in-depth research with his personal experiences as the BBC Moscow correspondent for almost twenty years, Sixsmith tells Russia's full and fascinating story, from its foundation in the last years of the tenth century to the first years of the twenty-first, skillfully tracing the conundrums of modern Russia to their roots in its troubled past. Covering politics, music, literature and art, he explores the myths Russians have created from their history. Marking the twentieth anniversary of the dissolution of the Soviet Union, "Russia" is essential reading for anyone who wants to understand the complex political landscape of Russia and its unique place in the modern world.
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MARTIN SIXSMITH is the author of "Moscow Coup: The Death of the Soviet System, The Litvinenko file: The True Story of a Death Foretold, " and two novels. Educated at Harvard, Oxford, and the Sorbonne, he was the BBC Moscow correspondent for many years.
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""Russia" delivers a thoroughly satisfying history...a lively opinionated narrative." -- "Publishers Weekly" ""Russia, a 1,000 Year Chronicle of the Wild East" has all the ingredients to become the leading popular history of Russia. Colloquial, personal and anecdotal in style . . . well researched and factually sound." -- "The Times Literary Supplement" "Sixsmith immerses readers in the Russian landscape and peoples with descriptions of places he's visited and quotations of poetry . . . Sixsmith effectively updates the continuities of Russian history, motivating readers to check out such scholarly surveys as Russia and the Russians, by Geoffrey Hosking." -- "Booklist" "Among the many contemporary books about Russia, general readers are likely to choose Sixsmith's 600-page tome for its comprehensiveness and air of authority. As popular history, it is enjoyable and engaging." -- Reading Behind the Lines, Russia "This entertaining, informative book presents a sweeping portrait of the entirety of Russian history from the founding of the first state on Russian soil in the ninth century to the present." -- CHOICE


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Our special coverage of the closest race for years
Meet Malaysia's first female mixed martial artist
16 Dec 2012 15:21 GMT | Sport, US Sports, Australia, Germany, India
A financial windfall awaits the world's leading field hockey stars when they play in a new Indian tournament next month on the lines of cricket's popular Indian Premier League.
The Hockey India League (HIL), sanctioned by the sport's world governing body, will have the top stars turn out for five franchised-based teams from January 17-February 17, organisers said on Sunday.
Indian captain Sardar Singh was picked up by the Delhi Wave Riders franchise for an annual salary of $78,000 at an auction that began in New Delhi on Sunday and was expected to continue late into the night.
Moritz Fuerste, named the International Hockey Federation's (FIH) player of the year for 2012 after helping Germany win two successive Olympic gold medals in Beijing and London, went to Ranchi Rhinos for $75,000.
Dutch veteran Teun de Nooijer, 36, was sold to the Uttar Pradesh Wizards for $66,000, while Punjab Warriors bought influential Australian striker Jamie Dwyer for $60,000.
Among other early gainers were Indian penalty corner specialist V.R. Raghunath ($76,000), Dutch goalkeeper Jaap Stockmann ($68,000) and Australian midfielder Eddie Ockenden ($65,000).
Mumbai Magicians was the fifth franchise in the fray.
Financial bonanza
The money paled in comparison to what cricketers make in the five-year-old IPL - where top players earn around $2 million a year - but was still a financial bonanza for the hockey stars.
Each of the five squads will have 10 foreign and 14 Indian players for the televised tournament described by HIL boss Narinder Batra as a "game changer" in the world of hockey.
"The tournament not only provides players a great platform to showcase their skills, but also helps them gain financial rewards and raises the profile of hockey in India and across the world," said Batra.
Among the renowned coaches signed up by the franchises, owned by Indian business houses, were Ric Charlesworth and Barry Dancer of Australia, and Roelant Oltmans of the Netherlands.
Hockey, often regarded as India's national sport despite the country's obsession with cricket, has been relegated to the background in recent years due to the team's poor showing in major events.
India, who won the last of their eight Olympic gold medals at the Western-boycotted Moscow Games in 1980, failed to qualify for the Beijing Games in 2008 and finished last in London.
The HIL follows the launch last year of the unsanctioned World Series Hockey, another big-money event organised by the rebel Indian Hockey Federation that opposes Hockey India.
Source: AFP
Extra-time heroics gives the Kookaburras a fifth consecutive trophy after they beat rivals Netherlands 2-1.
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Recent court ruling finds police unit not guilty of rounding up and executing 42 Muslim men during 1987 communal riots.
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Nigeria Decides, Nigeria, Africa
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Nigeria Decides, Nigeria, Goodluck Jonathan
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Two-horse race described as too close to call as presidential vote held after six-week delay due to Boko Haram.
Politics, Africa, Nigeria Decides, Nigeria, Boko Haram
It is a source of sustenance but also of tension and new political realities are now increasing uncertainty.
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DNR dedicates new Wildlife Management Area
A 1,036-acre parcel of land northeast of Alexandria officially became the Roger M. Holmes Wildlife Management Area (WMA) when it was dedicated Saturday, May 3.
Holmes is a former director of the Minnesota Department of Natural Resources (DNR) Fish and Wildlife Division. He also served as long-time chief of the division's Wildlife Section.
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Since I've been slacking a lot lately, I decided to crank it up a notch today.
I've done a couple of doubles before, but today was the first time I decided to go for 3. A little strategic planning and 7.5 hours later, I have a batch of Centennial Blonde, Porter, and an IPA in the primary.
I also Kegged my take on the 8-8-8 RIS that has been in secondary for 16 months (brewed 7-8-10) and dryhopped my 9-9-9 american barleywine in secondary for 14 months (brewed 10-16-10). I will carbonate in the keg and then transfer to bottles.
Exhausting day, but worth it.
i might try to do a double this weekend, but a triple just sounds exhausting!
Wow, great job. Never done that, but lots of doubles.
Sounds like a great day of success! I would love to do a triple brewday, I currently do 10g batches, I might have to buy more fermenters
7.5 hours to do 3? that's pretty good.
i just did a parti-gyle RIS, 1.102 and 1.045 small stout. took me damn near 7 and I had help.
Well done!
Done some doubles, but I'm afraid a triple brew day would almost seem like work.


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EvolveLight for EvolveSMS
Coming to a Play Store near you for .99 USD
Idealistically, this will turn into THE Holo Light theme for EvolveSMS.
If you have any suggestions and requests, comment them below. Im all ears!
App has been published to the Google Play Store, but will take a few hours before showing up. I'll make sure to notify you guys when it's up.
Last edited by MBQ_; 31st January 2014 at 01:21 AM.


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