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text:
A bioprocess container consists of a flexible container, placed inside a heat exchanger. By providing a disposable agitation device inside the sealed container, a filled container can be stirred without having to open the container. Possible agitation elements include traditional stirrers, rotating magnetic rods, bladder devices integral with the structure of the container, as well as different devices for manipulating the shape of the sealed container. Finally, a containment disk is used to ensure that the magnetic rod is maintained in the magnetic field.
1. A bioprocess container (BPC) comprising:
a sealed flexible container having a size and a shape when at least partially filled, and
a rigid heat exchanger, having a cavity corresponding essentially to the shape of said container, said container disposed at least partially inside said cavity.
2. The BPC of
3. A BPC mixing device comprising:
the BPC of
an agitator disposed at least partially inside said container.
4. The BPC mixing device of
a magnetic rod and a magnetic drive mechanism, adapted to rotate said rod; and
a shaft extending through said container and a mixing device disposed inside said container, at and end of said shaft.
5. The BPC mixing device of
6. The BPC mixing device of
a first ring,
a second ring secured to said first ring, defining a space therebetween, the space corresponding essentially to the shape of said magnetic rod.
7. The BPC of
8. A BPC mixing device comprising:
the BPC of
means for manipulating the shape of said container.
9 The BPC mixing device of
at least one bladder integral with the structure of said container and at least one inflating apparatus, in fluid communication with said at least one bladder;
a plurality of fluid-containing sleeves protruding from the interior of said container and a means for squeezing said plurality of fluid-containing sleeves;
a plurality of hinged plates, disposed on said container and a means for manipulating said plurality of hinged plates; and
means for displacing at least one edge or corner of said container.
10. A method for mixing comprising:
providing a bioprocess container (BPC), said BPC comprising:
a flexible container having a shape when at least partially filled, and
a rigid heat exchanger, having a cavity corresponding essentially to the shape of said container, said container disposed at least partially inside said cavity; and
agitating the contents of the container.
11. The method of
manipulating the shape of the container, and
mixing the contents of the container.
12. The method of
13. The method of
selectively inflating and/or deflating at least one bladder integral with the structure of said container;
selectively squeezing a plurality of fluid-containing sleeves protruding from the interior;
selectively moving a plurality of hinged plates, disposed on said container; and
displacing at least one edge or corner of said container.
14. A magnetic rod containment disk comprising:
a first ring;
a second ring, joined said first ring with a space therebetween; and
a magnetic rod disposed in said space.
15. The magnetic rod containment disk of
16. The magnetic rod containment disk of
17. The magnetic rod containment disk of
18. The magnetic rod containment disk of
[0001] 1. Field of the Invention
[0002] The present invention relates to the field of mixing containers of fluids, most often at least one liquid. More specifically, the device and method of the invention concern disposable, sealed containers and various devices and processes for mixing the contents therein.
[0003] 2. Description of the Related Art
[0004] The biopharmaceutical process industry has been moving toward technologies that use disposable manufacturing components versus stainless steel tanks and piping. One key component is bioprocessing containers (BPCs). Conventional manufacturing, mixing and/or stirring devices have been used in this type of industry for a considerable period of time. In one type of system, the various ingredients or components are introduced into a typical glass beaker.
[0005] When a large scale production is required, the glass beaker may be replaced by a large metal vat or other conventional industrial vessel that also provides heating and cooling capacity. In either system, the components are sequentially or consecutively added to the vessel where the mixing and/or stirring is conducted. In such systems, a stirring device is generally inserted through the upper, open face of the container and powered from an external source. Additionally, reuse of the conventional system requires significant cleaning and sterilization processes to ensure the absence of undesirable materials.
[0006] Improvements to the traditional beaker or industrial vat mixing systems include those described in U.S. Pat. Nos. 5,795,330, 5,941,635 6,076,457, and 6,190,913, each of which is herein incorporated by reference in its entirety.
[0007] In order to overcome the problems associated with conventional BPC mixing devices, the present invention utilizes a new container-heat exchanger combination. Specifically, the BPC of the invention generally includes a flexible container, placed inside a rigid heat exchanger. In one embodiment, the flexible container is destroyed and replaced after use to eliminate the necessity of cleaning and sterilization. The shape of the heat exchanger is selected to correspond to the shape of the flexible container when the container is filled. Because the container is inserted into a cavity in the heat exchanger, by matching the shape of the heat exchanger (in particular, the cavity) to the shape of the container, the efficiency of the heating and/or cooling elements can be increased.
[0008] The BPC of the invention is designed to be utilized with a mixing device. In a first embodiment, a shaft of conventional (optionally disposable) agitator passes through an opening in the container, with the stirring element disposed therein. A motor is provided at the other end of the shaft to rotate the stirring element.
[0009] A second embodiment utilizes a magnetic agitator. A magnetic rod is placed inside the container and a magnetic field is generated by a magnetic drive device to rotate the rod. By locating a magnetic drive device external to the container, preferably outside the heat exchanger, the container need not have an opening and may be sealed, albeit with the rod and optional containment disk therein. The magnet rod may be disposed inside a containment disk.
[0010] Alternatively, the container and/or heat exchanger may include mixing devices mounted thereto. In a third embodiment, the container has a series of discontinuous baffles, such that when the baffles are alternatively inflated and deflated, the contents of the container can be stirred. Similarly, the container may have a series of fluid-filled sleeves, such that the mixing is performed when the sleeves are squeezed. In a final embodiment, the container includes, on the outside thereof, a series of hinged plates, and the cavity of the heat exchanger includes corresponding mechanical plates. When the mechanical plates in the cavity apply pressure to the hinged plates on the outside of the container, the bag is compressed and the contents thereof mixed.
[0011]FIG. 1 is a partial is cut-away view of a first embodiment of the invention.
[0012]FIG. 2 is a partial cut-away view of a second embodiment of the invention.
[0013]FIG. 3a is an exploded view of a rod containment device of the invention.
[0014]FIG. 3b is a side view of a containment disk of the invention.
[0015]FIG. 4 is a partial cut-away view of a third embodiment of the invention.
[0016]FIG. 5a is an isometric view of a fourth embodiment of the invention.
[0017]FIG. 5b is an isometric view of a fifth embodiment of the invention.
[0018]FIG. 5c is an isometric view of a sixth embodiment of the invention.
[0019] A bioprocess container (BPC) in accordance with the invention is shown in the various figures, each figure detailing an embodiment thereof. FIG. 1 shows a BPC 10, comprising a flexible container 12 in conjunction with a rigid, jacket-type heat exchanger 14. Specifically, heat exchanger 14 comprises a cavity 15, defined by a bottom 16, and side walls 18. For simplicity, container 12 is shown as being seated in heat exchanger 14, however, optionally, a small section may extend above side walls 18 heat exchanger 14. Although container 12 and heat exchanger 14 are shown in the shape of cylinders, any three-dimensional shape may be used. Preferably, however, the shape of cavity 15 of heat exchanger 14 is selected as to correspond to the size and shape of container 12 when filled. When the sizes and shapes correspond, the exterior surfaces of container 12 contact the interior surface of cavity 15 to increase efficiency of heat transfer therebetween. In any event, although the shape of each of container 12 and cavity 15 may be any three dimensional shape, e.g., rectangular prism, cubic, substantially spherical, pyramidal, and conical, a cylindrical shape, having either squared or rounded-off comers, is preferred.
[0020] Although the structure and size of container 12 is not particularly limited by the invention, preferably, container 12 is cylindrically shaped (approximately 36″ diameter by 30″ high) and made of polymeric materials, such as polyolefins, thermoplastic elastomers, polyamides, polyesters, polyimides, polysulphones, or barrier polymers (such as MX D 6 available from Mitsubishi Gas Chemical America, Inc. of N.Y., ethyl vinyl alcohol, polychlorotetrafluoroethylene, polyvinyl chloride). Most preferred however are polyolefins, thermoplastic elastomers and polyamides, alone or in combination. The polymeric materials may be processed in a multilayer laminate and/or film with a thickness from about 2 to about 12 mils, typically about 4 to about 8, and preferably from about 6 to about 8 mils.
[0021] Preferably, side walls 18 of heat exchanger 14 contain liquid-transfer media in spirally arranged tubes. Thus, when heating of the contents of container 12 is desired, the liquid-transfer media can be either heated or cooled to add or remove heat from container 12. During operation, the liquid transfer medium is pumped from an external location (where it is heated or cooled), through the tubes (transferring heat either to or from container 12), and back to the external location. In order to cool container 12, the liquid transfer medium is first cooled before it is pumped into the tubes.
[0022] In any event, the liquid-transfer media may be replaced by conventional heating or cooling coils, such as electric resistance or refrigerant-filled coils. Such heating and cooling coils may be provided independently or may both be incorporated into the same heat exchanger 14. For example, heat exchanger 14 preferably comprises a series of circular heat exchanger plates in side walls 18, providing a means for transferring heat out of the water by circulating a colder liquid through closed channels on the plate surface.
[0023]FIG. 1 also depicts a BPC mixing device comprising BPC 10. Specifically, the BPC mixing device comprises BPC 10 and an agitator 22. Agitator 22, in one embodiment, comprises a shaft 24, extending through an aperture 25 in a first end 26 of container 12 as to maintain sealing of container 12. It is considered within the scope of the invention for aperture 25 to be a one-way port, allowing introduction of agitator 22 without allowing exit of the contents of container 12. One extreme of shaft 24 terminates in a stirring element 28, inside container 12. Additionally, a motor 30 is connected to the section of shaft 24 external to container 12. Alternatively, however, shaft 24 may extend through a second end 32 of container 12 and optionally through bottom 16 of heat exchanger, such that motor 30 is disposed either integral with bottom 16 or below heat exchanger 14. Although FIG. 1, shows motor 30 disposed at the extreme opposite end from stirring element, as long as motor 30 is located outside container 12, any location is sufficient.
[0024] It must be noted that as used herein, the terms �stir�, �mix� and �agitate� are considered equivalents and are interchangeable, as each simply means manipulating the contents of container 12 to, for example, to incorporate two substances (such as liquid into liquid or a solid into a liquid), or simply to disturb a single substance. Thus, no distinction should be inferred from the uses of these different terms.
[0025] Similarly, while stirring element 28 is depicted as a substantially flat, horizontally aligned device (with respect to the long axis of shaft 24), having multiple arms extending from a center, stirring element 28 need not be so limited. For example, stirring element 28 may be in the shape of a paddle extending vertically with respect to the long axis of shaft 24, or may have extensions extending in all three dimensions from shaft 24.
[0026]FIG. 2 illustrates a second BPC mixing device embodiment in accordance with the invention. Specifically, the agitator in this embodiment comprises a magnetic rod 40 and a magnetic drive mechanism 42 (not shown). Magnetic drive mechanism 42 can be any device capable of generating a rotating magnetic field, such as a second magnetic rod attached to a motor, located either integral with heat exchanger 14, such as in bottom 16, or somewhere external thereto. In order to increase the efficiency of stirring created by the rotation of magnetic rod 40, the surface upon which magnetic rod 40 rotates, e.g., second end 32, may be provided with a non-stick or non-abrasive, low-friction coating, such as a polyolefinic material, preferably polytetrafluoroethylene. Although rod 40 is described as a magnetic rod, rod 40 may also be a magnetizable material, such as ferrous metals or ferrous metal-containing materials.
[0027] For example, in such an embodiment, 485 L of water can be cooled from 70.1� F. to 49.0� F. in 2.0 hours. The cooling liquid supply in the plates of heat exchanger 14 set-point is 38� F. with the closed system supply operating in a range from 38.5-46.9� F. Continuous motion of the contents of the disposable container 12, formed from a modified polyethylene, is generated by rod 40, having a tapered shape (e.g., diameter of 25 mm and 90 mm long), rotating at 650 rpm. By recording the water temperature at 8 locations, including 4 depths, 3 radial distances and 4 locating angles, the mixing of the contents of container 12 can be measured. The data shown in Table I indicates that when the invention is employed, even or uniform cooling can be achieved.
[0028] In a second example, heat exchanger 14 heats the liquid in container 12, formed from a modified polyethylene, by circulating a liquid having a temperature hotter than the container 12. 446 L of water is heated from 41.9� F. to 77.6� F. in 1.3 liquid in heat exchanger 14 having a set point of 95� F., and the closed system operating in a range from 77.1-96.2� F.
[0029]FIGS. 3a and 3 b show a rod containment disk 100 of the invention. Conventional magnetic stirrers often become free from the magnetic field, and as a result, the mixing stops. Thus, the inventors have developed a containment disk, indicated at 100, into which magnetic rod 40 is placed. Due to the design of containment disk 100, rod 40 is prevented from exiting the magnetic field. In particular, containment disk 100 preferably has an upper ring 105 and a lower ring 108, which when assembled with bolts 110 and spacers 115, form the structure shown in FIG. 3b. The exploded view in FIG. 3a shows that bolts 110 pass through holes 112 in upper ring 105 and into threaded recesses 118 of lower ring 108. The length of bolts 110 and spacers 115 are preferably selected such that when constructed, the distance between upper ring 105 and lower ring 108 is large enough to allow rotation of rod 40 and permit substantially unobstructed fluid flow therein, while simultaneously preventing rod 40 from escaping containment disk 100. While containment disk 100 is shown in FIGS. 3a and 3 b as being a separate device, it is preferable to integrate at lower ring 108 onto a plate 120. Typically plate 120 is adhered to or part of container 12 and serves as the surface upon which rod 40 rotates.
[0030] Typically, each of upper plate 105, lower plate 108, bolts 110 and spacers 115 are constructed from the same types of materials as container 12, preferably a polyolefin and more preferably low-density polyethylene. However, it is also considered within the scope of the invention to form any one of the components of containment disk of other materials, such as metal. In order to reduce friction, plate 120 is also preferably at least coated with a reduced-friction coating, such as polytetrafluoroethylene.
[0031] Preferably, each of the components of containment disk 100 is injection molded and once assembled, the components are ultrasonically welded together with rod 40 placed inside. Additionally, while upper ring 105 is shown as having a central aperture 125, in a preferred embodiment, this aperture 125 is not large enough for rod 40 to fit through without disassembling containment disk 100 and is merely present to increase fluid flow about rod 40.
[0032] Because conventional magnetic rods are often tapered at their ends, the space formed between upper ring 105 and lower ring 108 is preferably similarly tapered. Because the particular shape of the tapered surface can correspond to the shape of the particular shape of rod 40 to be enclosed therein, containment disk 100 can effectively allow rod 40 to rotate freely without risking it leaving the magnetic field.
[0033] Although it is preferable to position containment disk 100 at the bottom of container 12 with magnetic drive mechanism 42 located below container 12, it is also considered within the scope of the invention to mount containment disk 100 removed from the bottom of container 12. This may be accomplished, for example, with one or more feet supporting containment disk 100, or by attaching the outer circumferences of upper ring 105 and lower ring 108 to the inside wall of container 12 at the desired location. Finally, plate 120 may be eliminated and lower plate 108 be provided with an aperture when containment disk 100 is not positioned at the bottom of container 12 to allow for efficient fluid flow. In order to rotate rod 40, magnetic drive means 42 may comprise, instead of a rotating magnetic field, a pulsating magnetic field, alternating polarities to drive rod 40 inside containment disk 100.
[0034] Containment disk 100 may also be equipped with a baffle element 110 attached to upper ring 105 (FIG. 3b). Preferably, baffle element 110 is included to hinder or otherwise prevent the contents of container 12 from forming a vortex during agitation. In conventional mixing devices using a magnetic rod, if any air is trapped inside the container, rotation of the magnetic rod causes the liquid to form a vortex, necessarily drawing air into the liquid. By including baffle element 110, the rotation of the liquid can be disrupted enough to limit any vortex formation, while increasing mixing efficiency. Preferably, baffle element 110 is similar in structure to upper ring 105, but may alternatively be of any shape or size capable of hindering the vortex-causing forces, for example, a rectangular prism, thin vertically-extending flange or pyramid. Additionally, a second set of spacers 130 maintain a space between baffle element I 10 and upper ring 105. Although spacers 130 are show as being substantially similar in size to spacers 115, the particular dimensions of spacers 130 are preferably selected as to position baffle element 110 in the location where the vortex-causing forces are greatest.
[0035] In an additional set of embodiments, the contents of container 12 are stirred by physically changing the shape and/or dimensions of container 12. By applying pressure to a particular area or location of container 12, the contents are displaced and moved to another location inside container 12. Thus, a shape manipulating means is utilized to stir the contents of container 12.
[0036] In a third embodiment, depicted in FIG. 4, container 12 comprises at least one bladder 60, capable of being filled with a fluid disposed about the periphery of container 12. In order to selectively inflate and/or deflate bladders 60, an inflating apparatus 62 (not shown), such as an air or water pump is provided. Specifically, by forming an inflated bladder 60 a, and a deflated bladder 60 b, container 12 can be manipulated to create forces therein to mix the contents. While bladders 60 are preferably formed integral with the structure of container 12, it is also considered within the scope of the invention to form bladders 60 in side walls 18 of heat exchanger 14 or as a separate inflatable/deflateable element between side walls 18 and container 12 (in which case bladders 60 may be affixed to side walls 18 and/or container 12 in a removable or permanent fashion). Bladders 60 may also be in fluid communication with conduits carrying the liquid-transfer media, such that by simply altering the volume or pressure of the liquid-transfer media, the shape of container 12 can be changed. Additionally, baffles 60 may be a single unit, or alternatively, multiple discontinuous units.
[0037] In a third example, liquid syrup was mixed with water in a flexible container and single continuous bladder supported by a rigid outer structure. The flexible container was cylindrically shaped, having a diameter of 8 inches, and a circumferential bladder (4 inches in diameter and 440 cubic inches in volume) located at one end. Both the container and bladder were formed from a plastic film, processed into a multilayer laminate with a thickness between about 2 and about 12 mils. A cylindrical outer structure, having an 11 inch diameter was also provided. One milliliter of liquid syrup was introduced at the bottom of 1.7 gallons of water. After 29 cycles (each cycle including inflating the bladder completely with air and subsequently deflating the bladder) over 2 minutes, approximately 90% of the syrup had become mixed into the water. This mixing percentage can be determined by any sufficient means, for example, by measuring optical color change or opacity of the water.
[0038] Furthermore, bladders 60 may be replaced by other devices designed to manipulate the shape of container 12 as to agitate the contents disposed therein. For example, FIG. 5a shows container 12, wherein static fluid-filled sleeves 70 are attached to the exterior. Thus, in order to change the shape of container 12, one or more sleeves 70 are squeezed by, for example, a clam-shell device, indicated at 71, which may be motorized or actuated manually. In order to perform the agitating, clam-shell devices 71 simply clamp down on sleeves 70 to force the contents of sleeves 70 into the main body of the container. When more than one sleeve 70 is provided, the sleeves 70 may be squeezed simultaneously or independently.
[0039] One or more arms 80 may be attached to container 12, as shown in FIG. 5b, such that when arms 80 are pushed, container 12 is deformed and fluid is forced from the area in proximity to arms 80. Preferably, a stationary baffle 81 is provided near arms 80, such that before entering the main section of container 12, the fluid must first pass stationary baffle 81. Additionally, arms 80 may be pulled to deform container 12 by stretching. Preferably, when arms 80 are utilized container 12 resembles a rectangular prism or a cube, with arms 80 positioned at the edges thereof. Most preferably, arms 80 are disposed at the edges, most preferably at each of the corners of container 12.
[0040] Finally, container 12 may be provided with a system comprising at least one hinged plate 90 (FIG. 5c), while heat exchanger 14 includes at least one mechanical plate 95 (not shown), corresponding to the location and number of the hinged plates, such that mechanical plates may be activated to create a pulsation in container 12. Preferably, mechanical plates 95 in heat exchanger 14 correspond in number and position to hinged plates 90 in container 12, such that each mechanical plate 95 impinges upon a separate hinged plate 90. Thus, the manipulation of hinged plates 90 functions to massage container 12 to agitate the contents therein.
[0041] Although the present invention has been described in terms of specific embodiments, it will be apparent to one skilled in the art that various modifications may be made according to those embodiments without departing from the scope of the applied claims and their equivalents. Accordingly, the present invention should not be construed to be limited to the specific embodiments disclosed herein.
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Cool! Cheap, effective and will probably fit nicely between a keg and the corner of the keezer/fridge.
I might get one.
does anyone have one of these yet?
Long story short, Beer.
Posting here to remind me in a month you also have the Nitrogen tanks in the same size. If I don't find one locally at that price.
Landshark: The Betty White quote is F***ing hilarious
Don't worry about old age; it doesn't last that long."
Dimensions please....
Primary 1: Lonely
Primary 2: Lonely
Secondary 1: Orange Mead (Made Jan. 2013)
On Tap #1: Stormy Monday IIPA
On Tap #2: Mild Thing English Brown
On Deck: Thinking....
What is a siphon tube and what does it do for a kegging system?
Any pictures of these things in use?
I am trying to get a good deal for a CO2 tank, and this seems like the best bargain. I have 3 kegs and am starting to get the supplies for a keg setup, but am avoiding jumping the gun until I learn what all I need for my setup.
If hooking up to a regulator, will it make this any taller? It is taller than corny kegs from the dimensions I have seen. Probably going with a chest freezer for keg setup.
Started brewing February 2012:
All grain and partial mash brewer depending on time. Meads and apfelwein also.


text:
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As part of our ongoing efforts to maintain and improve the accuracy of the RIPE Registry, we have updated the registrations concerning two legacy /8 IPv4 address blocks: 53/8 and 57/8.
- RIPE NCC to Reuse Referenced 16-bit ASNs
In accordance with the decision of RIPE Working Group Chairs, the RIPE NCC will start reassigning referenced ASNs once the pool of unreferenced 16-bit ASNs has been exhausted.
- Policy Proposal Implemented: 2012-07 "RIPE NCC Services to Legacy Internet Resource Holders"
The RIPE NCC has begun implementation of RIPE Policy Proposal 2012-07: "RIPE NCC Services to Legacy Resource Holders".
- RIPE NCC Launches General Meeting Registration Through LIR Portal
The RIPE NCC launched General Meeting registration for voting and attendance for the November 2014 meeting


text:
Our advisers are there to help you make an informed decision and will tell you straight away if equity release isn't the right option for you.
Is it right for you?
Some points for you to consider before you take out an equity release plan:
- Releasing equity from your home is a lifetime commitment, and is only expected to be repaid when your home is sold, usually when you and your partner pass away or move into long term care. If you do decide to pay back early, early repayment charges may apply.
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- All equity release plans will reduce the value of your estate.
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Cyberaide Virtual Appliance: On-demand Deploying Middleware for Cyberinfrastructure Tobias Kurze, Lizhe Wang, Gregor von Laszewski, Jie Tao, Marcel Kunze, Fugang Wang, David Kramer, Wolfgang Karl, and Jaliya Ekanayake Outline • Research background: Grid computing & Cloud computing • Research motivation • Cyberaide virtual appliance • Test results • Conclusion and future work Grid computing • Effective computing paradigm for distributed high performance computing applications • A number of production Grid infrastructures, projects, applications: – TeraGrid, EGEE, WLCG, FutureGrid, D-Grid … • Disadvantages of current production Grids: – Overloaded Grid middleware – Complicated access interfaces and policies – Limited QoS support – No personalized computing environment provision Cloud computing • That's why we are here • Attracting features: – On demand service provision – Utility computing model: pay-as-you-go – Customized computing environment provision – Automatic and autonomous service management – User centric interfaces with broad network access – Scalable services with resource pooling – …… Cyberaide Project • An open source project, collaborated between Indiana Univ., KIT, RIT, … • PI: Dr. von Laszewski • A middleware for clusters, Grids and Clouds – Cyberaide virtual appliance – Cyberaide shell – Cyberaide mediator, cyberaide server, – Cyberadie creative – …… Motivation • Challenging question: can we build Clouds on exiting production Grid infrastructures? • Our current research objectives: – On-demand access Grid resources from ad-hoc clients? – SaaS on production Grids? – …… On-demand access production Grids • Interfaces of Production Grids are strictly defined: – Resource information – Security – Job submission and management • Access resources of production Grid – from ad-hoc clients – without special client software & Grid expertise – on-demand access at runtime Cyberaide shell, mediator and server Cyberaide Virtual Appliance: overview • Cyberaide Virtual Appliance – Put cyberadie shell, mediator and server into a virtual machine, – On demand deploy cyberaide virtual appliance to access production Grid – User can access production Grid via cyberaide virtual appliance • Advantages – Cyberaide virtual appliance can be dynamically deployed with policy customization, like user account, access URI, .. – Multiple users can share a cyberaide virtual appliance, then build a VO – A cyberaide virtual appliance can be managed easily, for example, start, shutdown, migration, duplication, .. Cyberaide virtual appliance: Solutions • Vmware Studio vs. JeOS VMBuilder Criteria Vmware Studio JeOS VMBuilder User interface Very good Less comfortable Support OS Ubuntu, SUSE, RedHat, Ubuntu JeOS only CentOS Support hypervisor Vmware Vmware, Xen and KVM Auto support on Yes no hypervisor Ease of use Some technical good problems • JeOS VMBuilder is selected Cyberaide virtual appliance: Implementation • Four configuration files for Boot and Login: – A basic configuration file that allows to define some basic parameters such as: platform type (i386), amount of memory of the virtual appliance, packages that should be directly installed, etc. – A hard-disk configuration file that defines the size of each available (virtual) hard-disk and the number and size of all the partitions that will be created on these hard-disks. – Boot.sh: Shell script that will be executed during the first boot of the new appliance. – Login.sh: Shell script that will be executed after the first logon in the new appliance. • One script is for adapting the VMbuilder configuration files • One script is for transferring the appliance to the target host and starting it on the specified hypervisor. Cyberaide Virtual Appliance: Build process Test result: Web portal on TeraGrid Test result: performance evaluation on TeraGrid Metrics value Building time (basic OS packages) 10 minutes Building time (full system image) 20 minutes Deployment time 15 minutes Total time 40 ~ 60 minutes Virtual machine image size (basic OS package) 400 MB Virtual machine image size (full system image) 2.8 GB Conclusion and Future work • Cyberaide virtual appliance: – on demand deploy middleware for Grid computing – Test on production Grid • Future work – Cyberaide onServe: Software as Service on production Grid – Cyberaide Farm: develop Cloud computing program model on production Grid – Cyberaide Green: provide green Grid computing & Cloud computing
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Candia voters to deliberate on $2.4M plan
Candia does not have a town administrator. Becker said she performs accounting work for the town.
The town seeks $75,000 for excess winter road maintenance with the stipulation that the funds won't be used unless the winter budget is depleted, and $50,000 for the Apparatus Capital Reserve fund, which is used for the purchase of fire apparatus and equipment. To help pay for future property reevaluations, $20,000 is being asked for the Revaluation Capital Reserve Fund.
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Hi. 3 Days, thats how long I just spent trying to get this to render. P5 crashed over and over (and over) again, I finally had to settle for a pathetic 640 by 660 at 200 dpi as nothing else would work. This means I kind-of have mixed feelings about this image, I happy (because it's Tao and she makes me smile) but I'm angry (because it shouldn't be this hard to finish a render!!!!!!!!!!). Hands up who wants a more stable rendering engine in Poser 6?
This is using my own custom light set built to work with the staggeringly good Hyperreal for V3 (which also works with Young ten Laura btw :D). I'm not kidding - if you've got P5 this is just too good to miss. 8 spot lights and two infinite lights - took quite a while to setup. I think it worked pretty well when I finally got it to render.
Thanks for looking :) Cheer me up and give me a comment :)
Production Creditsface_off - The incredible Hyperreal for V3
Morris - and
Blackhearted - Black eyes, Actual Eyes 2
Jan 23, 2005 1:38:26 pmby i-popba Homepage »
Wowww..!! Excellent work..!! cool skin and mood...just wonderful my friend..!! love it..!
Jan 23, 2005 1:42:16 pmby PeCass Homepage »
Excellent, very good work!
Jan 23, 2005 1:42:53 pmby lunaris Homepage »
Awesome realism on this one!! You're right, P5 renderer is not stable. Hands up from me on more stable engine for P6 :) EXCELLENT!!
Jan 23, 2005 1:45:06 pmby tattdnpierced Homepage »
I am dealing with the same problem and I found out that it was the raytracing of the hair that takes the time to render... If you take your same image and render without the hair it will be quick. Key is to raytrace the head without having to do the hair.
Jan 23, 2005 1:45:42 pmby Aimee Homepage »
Great skin texture and wonderful eyes! She's lovely! And yes, I know this problem, so *hand up* for better render!!!
Jan 23, 2005 1:52:13 pmby prog Homepage »
Gorgeous looking texture!!! EXCELLENT work!!!
Jan 23, 2005 2:16:44 pmby kjlintner Homepage »
Stunningly good! Excellent work!
Jan 23, 2005 2:20:32 pmby iamkate101 Homepage »
I think she looks just incredible!! Your lighting is excellent. I have such a hard time with lighting ::sigh:: dont think I will ever get the hang of it! this is just excellent and I think your time was well spent working on it :)
Jan 23, 2005 2:24:40 pmby Cybrea Homepage »
She looks great, excellent work !!
Jan 23, 2005 3:02:30 pmby Morris Homepage »
Gorgeous portrait what a little doll and such beautiful eyes!
Jan 23, 2005 3:22:57 pmby ilumminati Homepage »
Bravo maestro! Just curious: what happened with your Poser to Maya work? Are we going to see something from that?
Jan 23, 2005 3:41:35 pmby face_off Homepage »
This is a knockout image. You light setup is excellent. Love the pose, skin tones, and her teeth even look good!
Jan 23, 2005 4:09:00 pmby Unicornst Homepage »
Yep....Pretty real! Even down to the little beauty mark near her mouth. She's beautiful in that special beauty children have. Full of fun and innocence. Hate that it took so long and gave you so many problems, but well worth the effort!
Jan 23, 2005 6:44:40 pmby richardson Homepage »
Hawke, you can get this with 2 spots and maybe 3 infinites. 8 spots with shadows will fill up to your max in no time. Closeups are a pc killer too. Nice render and agree about HRS!
Jan 23, 2005 7:18:56 pmby NEThingbutNOcent Homepage »
Beautiful portrait! That expression is priceless! Excellent job! :)
Jan 23, 2005 10:43:57 pmby shutterb Homepage »
Your light did the trick!!!!! Great image with a beautiful face and expression.
Jan 23, 2005 11:17:44 pmby dadamson Homepage »
P5 hasn't crashed on me for a LONG time now (about 3 months) when I use the firefly renderer. (I was having the same problem with Vue as well). I upgraded to 3 GB of 3200 RAM. I plan to MAX my PC out at 4 GB this week. I am hoping that P6 has beeter memory utilization. But until then... your image, even at this size, ROCKS!!
Jan 24, 2005 8:57:08 amby STEVIEUKWONDER Homepage »
Well Stuart, I must say, this is absolutely exemplary. Very beautiful indeed. You are extremely talented.
Steve :o)
Jan 24, 2005 7:28:40 pmby tony_br22 Homepage »
sure looks real .. and your own lightsetting there is just awesome. Sorry to hear the Poser has such unstable renderengine (I just ordered Poser so could get me a little worried :-) .. Your work here is excellent Hawke (btw. what a cool hair you made also)
Jan 25, 2005 7:35:13 pmby calum5 Homepage »
Yep my p5 render crashed after an hour!I upped the virtual memory and rendered a 1400 x 1400 in about 30 mins fine!I love that pac and your lights look great!!Bye calum
Jan 27, 2005 10:24:50 amby Jay7347 Homepage »
Really nice portrait!!! Love your texture and light. If you're having a problem with the crashing you might want to look at your bucket size. I started going with a 16 and then 8 instead of the default 32 and it cleared up that issue with me. Of course my renders 300dpi 3600x? were still up around a day on my dual gig mac. Best of luck!
Jan 28, 2005 1:50:31 amby Gor111 Homepage »
Yes she is! Fantastic face and expression! Very beautiful eyes and a marvellous natural lightning!!! ***V***
Jan 30, 2005 3:15:17 pmby VigilAnnie Homepage »
She is very cute. I love that expression on her face.
Jan 30, 2005 11:16:27 pmby MOOOW Homepage »
wow!!!!!!excellent artwork indeed,very real skin texture and fantastic portrait*VOTE*
Feb 7, 2005 3:25:15 pmby hjoellers Homepage »
YES! the most is already write (say) above ... SMILE ... and YES this looks really REAL ... WOW ... and i can understand your feelings about the FireFly and P5 ... i hope there is something MUCH better in P6. and once more this is simply wonderful a wonderful REAL portrait
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Efficacy of tourniquet ischemia for strength training with low resistance
- M: Shinohara,
- Motoki Kouzaki,
- Takeshi Yoshihisa,
- Tetsuo Fukunaga
- … show all 4 hide
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To investigate the efficacy of ischemia in strength training with low mechanical stress, tourniquet ischemia was utilized in low-resistance training. Five untrained subjects conducted one-legged isometric knee extension training with one leg ischemic (I-leg) and the other non-ischemic (NI-leg). Repeated isometric contractions for 2 s with 3 s relaxation in between were continued for 3 min and conducted 3 days/week for 4 weeks as training. Training resistance was 40% of maximal voluntary contraction (MVC) of respective leg and tourniquet ischemia was applied during I-leg training. MVC in I-leg after 2 weeks (9% gain) and 4 weeks (26% gain) were significantly higher than pre-training value (p < 0.05). A significant increase in maximal rate of torque development in I-leg was observed after 4 weeks (p < 0.05). On the contrary, there was no significant changes in either of the parameters in NI-leg. As a consequence, the differences between legs for both parameters were significant after 2 and 4 weeks (p < 0.05 or p < 0.01). The substantial gain in strength and maximal rate of torque development in I-leg demonstrated the efficacy of tourniquet ischemia during low-resistance training of short duration, and suggested the importance of neuromuscular and/or metabolic activity, other than high mechanical stress, to the adapting responses to strength training.
- Title
- Efficacy of tourniquet ischemia for strength training with low resistance
- Journal
European Journal of Applied Physiology and Occupational Physiology
Volume 77, Issue 1-2 , pp 189-191
- Cover Date
- 1997-12-01
- 10.1007/s004210050319
- Print ISSN
- 0301-5548
- Online ISSN
- 1439-6327
- Publisher
- Springer-Verlag
- Additional Links
- Keywords
- Key words Strength training
- Tourniquet ischemia
- Fatigue
- Maximal voluntary contraction
- Industry Sectors
- Authors
- M: Shinohara (A1)
- Motoki Kouzaki (A1)
- Takeshi Yoshihisa (A1)
- Tetsuo Fukunaga (A1)
- Author Affiliations
- A1. The University of Tokyo, Laboratory of Sports Sciences, Department of Life Sciences, 3-8-1 Komaba, Meguro, Tokyo, Japan 153, JP


text:
MAC Mineralize Blush - Warm Soul
251 reviews
88% would repurchase
Package Quality: 4.3
Price: $$$
Package Quality: 4.3
Price: $$$
on 8/7/2013 5:44:00 PM
Age: 36-43
Skin: Dry, Fair, Cool
Hair: Brunette, Wavy, Fine
Eyes: Hazel
Oh. Wow. I went to the MAC counter to find a cheaper blush similar to my fave Miel Glac� from Lanc�me. I go through Miel Glac� in about 6 months and it's $30. I was looking at Cubic, which was pretty, but looked too matte. I also picked up Gleeful, but it looked a little red. The MA suggested Warm Soul, and I was instantly turned off when I saw it. In the pan it looked very bronzey with no rosiness. I am cool with a lot of pink in my skin and warm blushes usually look orange on me and clash with my skin tone.
I was definitely not expecting this color to give me a beautiful, natural flush, but it does. It is a warmer shade with peach tones, but it either works with my natural pinky tones or has a rosy undertone, because I get a very natural pinky-peach flush when I wear this.
The only con is that this is $25 and holds 11 oz of product. It seems that a little will go a long way, so hopefully this will last longer than six months. I might end up getting Cubic and mixing it with Warm soul to give it a little sheen. Overall, this is a great blush that will suit both cool and warm tones.
on 7/30/2013 2:12:00 PM
Age: 19-24
Skin: Combination, Fair, Neutral
Hair: Blond, Straight, Medium
Eyes: Blue
I am in love with this blush. It is a gorgeous natural tan with slight peach undertones and it gives your face the most perfect soft, tan glow. I have fair skin and I often have to be very careful with blush to make sure I do not over apply. With this blush, I don't ever have to worry about it looking over done. I hesitated to try this blush for the longest time because at the MAC counter the lights always made it look crazy shimmery. But it does not look like that on, it just gives a gorgeous natural finish to the skin and makes you look healthy and glowing. If you want soft natural looking blush or you're not usually a fan of how blush looks on you, I think you'll really love this color. I use the Real Techniques Multi Task brush to apply this.
Also, if you love Warm Soul I also recommend Tarte's Amazonian Clay Blush in Exposed. It's another amazing natural looking blush and one of my all-time favorites.
on 7/28/2013 1:31:00 PM
Age: 19-24
Skin: Combination, Tan, Warm
Hair: Blond, Wavy, Medium
Eyes: Hazel
I think I'm in love with MAC blushes. Warm Soul is exactly what it sounds like. It sincerely makes you look like you're glowing from within, and it brings this warmth to your face that's incredibly natural yet glowing. It isn't super pigmented but it is very build-able. I usually use this alone for a pretty summery look or sometimes when I want a bit more I use "Immortal Flower" first, and then this on top of it. They blend together very well. I add a contour directly underneath and then blend together. I also HIGHLY recommend using NARS' "Albatross" Highlighter with this - it gives the most gorgeous, ethereal glow. I use this basically everyday and for a good reason!
on 7/28/2013 7:26:00 AM
Age: 30-35
Skin: Combination, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Hazel
Yes it's a bit expensive but it lasts forever as you don't need much for it to show. It also goes with everything. Most definitely my favourite blush ever!
on 7/16/2013 5:40:00 AM
Age: 30-35
Skin: Combination, Fair-Medium, Warm
Hair: Brunette, Straight, Fine
Eyes: Green
Beautiful warm peachy color with golden shimmer. Gives radiance and glow to the skin without being too shimmery. Applies and blends easily.
For ref: I am NW20/25, and like it slightly better in the summer months.
on 7/11/2013 12:30:00 AM
Age: 19-24
Skin: Combination, Olive, Warm
Hair: Brunette, Straight, Coarse
Eyes: Brown
I have a sephora blush from one of their old palettes, and whenever i remember to wear it, my husband literally molests me. Its a very light apricot thats hard to dupe and since im all for finding dupes as a challenge, I searched high and low for a similar shade with no avail. Everything was much too orange or "peachy" which isnt bad, but it just wasnt what i was looking for. I looked at many a swatch and decided that i had to see MAC peaches, melba, sincere, tenderling, and stay by me in person to find the correct dupe, or at least a likable color.
When i got to the counter, i swatched all of them. Orange, even more orange, brown, nasty, no and NO. I think stay by me was a very close dupe for the color, and got it anyway.
The point of the story is, a kind MUA pointed out warm soul to me as an alternative even when i thought it looked way scary in pan. Nope! It is like a beachier, tan alternative to that sephora shade, with just a hint of sheen on the cheeks. It pulls peachy, but not to the point of orange fake bake. Whats even better is that it made me look alive, refreshed, and genuinely blushing without blush. Sold! Im guessing it would be beautiful for very pale shades as well as darker tones as well as long as they are warm toned.
I hope to see lasting power with this, as Ive never tried mac blushes before. It is very pigmented, and i only need to pick up a bit each time so i can see this lasting forever. I hate the cheapo plastic case, but oh well since most blush cases unless they are NARS feel cheap to me. I can attest that the color is absolutely wonderful on my nc30 skin and complements neutral eye makeup looks very well. I will be rocking this for the summer, and use my stay by me once i lighten to nc20 in the winter so that i will captivate my husband forever and ever. Hah.
on 6/12/2013 1:03:00 AM
Age: 25-29
Skin: Combination, Dark, Warm
Hair: Brown, Other, Fine
Eyes: Brown
This is my holy grail blush. This is a shade that I feel will suit any skintone. It gives you a soft, natural glow to the cheeks and for those who don't care for having TOO much color on the cheeks like myself, this blush is for you. It's a gorgeous color.
on 5/25/2013 1:38:00 PM
Age: 25-29
Skin: Combination, Fair, Warm
Hair: Brown, Straight, Other
Eyes: Green
OMG do I love this stuff! Expensive? Yes. Would I buy it again? Sure would!
I cannot say enough great things about this. It has a soft bronze to it with some hints of peach and some slight sheen to give my NC20 skin an absolutely beautiful looking healthy glow. I wore it yesterday on it own with MSF soft and gentle as a highlight above my cheeks and actually got a compliment on my makeup and blush from a makeup artist I know. I was thrilled as I've recently been getting more into makeup and figuring out how to blend eyeshadow well, pick blushes/lipsticks that look good on me, etc.
This blush is also great because you can build it up or keep it very subtle. Sometimes I will wear it alone if I'm looking for more of that soft bronzy look and sometimes I will put this over blush to give my self more of that sun kissed look.
I can't imagine anyone not liking this if you have warm undertones. LOVE> LOVE> LOVE!
on 5/20/2013 9:22:00 AM
Age: 19-24
Skin: Combination, Medium, Warm
Hair: Black, Straight, Coarse
Eyes: Brown
Favorite pinkish blush. In the morning I mostly grab this, and after it I mostly throw it in my bag with a blush brush if I need to fix it up during the day. When I run out of this baby I'll make sure I already have a back up in my make-up collection!!
on 4/30/2013 5:59:00 AM
Age: 19-24
Skin: Dry, Tan, Not Sure
Hair: Black, Other, Other
Eyes: Brown
This is my HG blush. This looks soooo beautiful on my tan skin (NC42)
This gives you a gorgeous glow. I've read somewhere that NARS Madly blush is a dupe for Warm soul.
But will definitely buy this blush again. It is also the perfect blush if you are wearing bold lips or smokey eyes.
Popular Blush Products


text:
High school boys basketball: 3A team-by-team region capsules
Coach Comment: "We will be a very athletic team that is going to get out and run and play hard, pressing defense."
Head Coach: Dan Lunt (20th year)
2011-2012 Record: 18-6 (1st in Region 12 with 10-0 record)
2012 Postseason: Lost to Cedar in the 3A quarterfinals, 54-38
Returning Starters: 1
Returning Contributors:
Kaleb Wright, Sr., Guard/Forward, 7.8 ppg, 4 rpg
Jacob Humphreys, Sr., Forward, 0.6 ppg
Mark Wolf, Jr., Forward
Daniel Reno, Jr., Guard
Coach Comment: "Very young team with only two seniors. Should be a good defensive team that will create a lot of turnovers with its length."
Head Coach: Jesse Roberts (3rd year)
2011-2012 Record: 10-12 (Tied for 4th in Region 12 with 4-6 record)
2012 Postseason: Lost to Morgan in the 3A first round, 83-72
Returning Starters: 1
Returning Contributors:
Ty Henry, Sr., Guard/Forward, 1.5 ppg, 1.3 rpg
Taylor Parker Jr., Forward/Center, 1.1 ppg, 3 rpg
Cameron Money, Sr., Forward, 4.7 ppg, 6.2 rpg, 1.6 spg
Coach Comment: "Our team had a great offseason and we look forward to the addition of some new faces on the team. We have a great group of upper-class contributors and some young guys with a ton of potential. Our preseason schedule will tell us a lot about who we are. Our goals are to prepare the kids for region play and a state tournament berth."
Head Coach: Cris Hoopes (2nd year)
2011-2012 Record: 8-13 (Tied for 4th in Region 12 with 4-6 record)
2012 Postseason: Did not qualify
Returning Starters: 2
Returning Contributors:
Jake Bailey, Sr., Center, 11.4 ppg
Jordan Christensen, Sr., Guard, 1.8 ppg
Coach Comment: "Our season will depend on hard work and leadership. We look to our seniors for both."
Head Coach: Jared Smith (11th year)
2011-2012 Record: 10-12 (2nd in Region 12 with 6-4 record)
2012 Postseason: Lost to Dixie in the 3A quarterfinals, 52-43
Returning Starters: 1
Returning Contributors:
Taylor Bahr, Sr., Forward, 9.4 ppg, 4.1 rpg, 1 spg
Dallin Christensen, Sr., Center, 1.3 ppg, 2.3 rpg
Hunter Johnson, Sr., Guard, 1.7 ppg
Head Coach: Jake Downard (1st year)
2011-2012 Record: 5-14 (6th in Region 12 with 1-9 record)
2012 Postseason: Did not qualify
Returning Starters: 2
Returning Contributors:
Curtis Orme, Sr., Guard, 4.3 ppg, 1.5 rpg
Kaden Kelson, Sr., Guard, 2.4 ppg, 2.2 rpg
Jeff Rowley, Jr., Guard, 2.0 ppg, 1.5 rpg
Josh Clark, Jr., Forward
Coach Comment: "We are optimistic about this upcoming season. Returning a couple of starters, this team is scrappy and plays with a lot of energy."
Deseret News prep writer Andy Sorensen contributed to these capsules.
- Jazz knock off Thunder in emotional game with...
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- Former Jazz big man Enes Kanter goes off,...
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- Brad Rock: The unforgettable Hot Rod Hundley
- Photo gallery: BYU rugby blanks Utah State in...
- 5 things you may have missed at BYU...
- Dick Harmon: Nomadic hoops coach Tony Ingle...
- A not-so-Sweet 16 for the Runnin' Utes... 120
- Former Jazz big man Enes Kanter goes... 38
- Brad Rock: Utes shouldn't feel bad, in... 34
- Utes went down swinging in Sweet 16... 29
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- AP All-Americans: Utah's Wright named... 19


text:
Cal State Fresno
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Your Cat, Your Life
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Your cat loves a clean toilet -- don't we all? Catster's singing Cat Lady, Sarah Donner, explains why.
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Thank you for my messages, wishes, rosettes, gifts and love on my 16th birthday - I am here at the Rainbow Bridge with many that I came to know at Dogster/Catster. It is good to be able to be near your friends forever, they are always there for you. Lots of love love love, Angel Rocky
It is 4 years that I have come to the beautiful Rainbow Bridge. My family will always miss me, but with the kindness and support of friends and family, the day is filled with love and memories from so many. That is a comfort and joy to know you are remembered. Sending Angel love to all of my dear friends and sweet family. xoxo Angel Rocky xoxox
I tried to buy some zealies today, but they are not accepting any orders. Sadly to think that I could have bought more last week, but who thought that far ahead?
We were going to answer some of our beautiful "Hugs" messages and use rosettes to thank our dear friends for all the loving thoughts that have been sent to us, Sarge, Abby Grace and me, Rocky, I'm an angel, mom always said I was!
Then, mom looked at her zealie balance and there were 103 zealies in it instead of 3! It was just so amazing!
Some kind person send these to us, please let us thank you as we will use every one of them to send our heart felt token of the love we have for all of the Dogsters and Catsters.
It has been a wonderful time here, since October 2005, we have enjoyed every minute, all the groups, the Strolls, the fundraisers, Adopt a Thon, the collections to send some cheer to a friend in need - all of these things have been so special.
There will never be another Dogster, there couldn't be, it is one of a kind and in each of our hearts, forever.
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4th Sorrowful Mystery: The Carrying of the Cross
I wonder if perhaps it was tempting for Jesus to just lie down on the dirt road and die right there. Completely sapped of strength and in agonizing pain, I wonder if He was tempted by the thought, "I can't take another step."
"Finally, Pilate handed him over to them to be crucified. So the soldiers took charge of Jesus. Carrying his own cross, he went out to the place of the Skull (which in Aramaic is called Golgotha.) John 19:16-17
The fruit of the mystery is perseverance and patience.
He is still standing after a brutal flogging that probably should have left him dead. His flesh is already mutilated and profusely bleeding, and His body is weak and shaky from the blood loss. Yet somehow, He withstands the pain and keeps going. I wonder if maybe the soldiers, besides being irked, weren't just a little impressed that He was still alive after all they'd done to Him.
Maybe that's why they enlisted some help for Him and made Simon carry the cross the rest of the way to Golgotha. "A certain man from Cyrene, Simon, the father of Alexander and Rufus, was passing by on his way in from the country and they forced him to carry the cross." Mark 15:21
But whether Jesus could walk or not, they were determined in their cause. Nothing was going to keep them from their final goal of execution.
Jesus persevered. So did Satan.
Satan was every bit as determined as Jesus that day and he was getting plenty of help from those blood-thirsty Roman soldiers. In this battle between Love and Evil, it was beginning to look like Satan would enjoy a raucous victory.
Thus far he had succeeded in shredding Jesus' body and utterly humiliating Him. Not a bad day's work for a fallen angel.
(Ah, but things are not as they seem! Evil was about to be soundly, eternally defeated.)
I wonder if perhaps it was tempting for Jesus to just lie down on the dirt road and die right there. Completely sapped of strength and in agonizing pain, I wonder if He was tempted by the thought, "I can't take another step."
How many times have I had that thought? It seems to me that my cross is getting too heavy, or I have been carrying it for too long, and I can't take another step. I feel weakened by some harsh blows, and it looks as though the enemy is winning.
In faithful obedience to the Father's will, Jesus persevered. So must I. Though it seems the enemy is scoring too many points against me, I must remember he has already lost. Though I'm sapped of strength and in pain, if I remain faithful, Satan will not prevail.
"Keep walking," Jesus says to me. "I will carry you when you are weak. I will never leave you. I have been to hell and back for you, and there's nothing to fear."
"Keep walking."
Jennifer Hartline is a grateful Catholic, a proud Army wife and homeschooling mother of four children. She is a contributing writer for Catholic Online. Visit her online at Wake Up, Deborah!
Pope Francis: end world hunger through 'Prayer and Action'
Copywriter 2015 - Distributed by THE NEWS CONSORTIUM
Pope Francis Prayer Intentions for March 2015
Universal: Scientists: That those involved in scientific research may serve the well-being of the whole human person.
Evangelization: Contribution of women: That the unique contribution of women to the life of the Church may be recognized always.
Keywords: rosary, sorrowful mysteries, carrying the cross, patience, pain, suffering, Jennifer Hartline
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For most people the easiest practice to consistently fulfill will be the traditional one, to abstain from meat on all Fridays of the year. During Lent abstinence from meat on Fridays is obligatory in the United States as elsewhere. Christ Himself said that His disciples would fast once He had departed (Lk. 5:35). continue reading
Everything answered from when does lent end, ashes, giving something up, stations of the cross and blessed palms. The key to understanding the meaning of Lent is simple: Baptism... continue reading
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Ash Wednesday
Ash Wednesday marks the beginning of the Season of Lent. It is a season of penance, reflection, and fasting which prepares us for Christ's Resurrection on Easter Sunday, through which we attain redemption.
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Opening Prayer
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Fasting & Abstinence
'Christ Himself said that His disciples would fast once He had departed' Lk. 5:35
Abstinence. The law of abstinence requires a Catholic 14 years of age until death to abstain from eating meat on Fridays in honor of the Passion of Jesus on Good Friday. Salt and freshwater species of fish, amphibians, reptiles and shellfish are permitted.
Fasting. The law of fasting requires a Catholic from the 18th Birthday (Canon 97) to the 59th Birthday (i.e. the beginning of the 60th year, a year which will be completed on the 60th birthday) to reduce the amount of food eaten from normal. The Church defines this as one meal a day, and two smaller meals which if added together would not exceed the main meal.
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A reproduction claw-foot "wood-burning" stove in the kitchen has all the modern accoutrements, including convection oven, gas top, and digital controls hidden in an upper bun warmer. Maple butcher-block counters surround the deep farmhouse sink.
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Mon centre cède, ma droite recule, situation excellente, j'attaque. The lower he sinks in the opinion polls, the more pugnacious Nicolas Sarkozy becomes. His favourite target is Britain - specifically, free-market capitalism as he imagines it to be practised in Britain.
Earlier today, in an especially bizarre outburst, he picked on the Financial Times. 'The FT, as they say in informed circles, has always defended the Anglo-Saxon model, considering the French incorrigible and that we would do better to align ourselves to the Anglo-Saxon model,' he said during a television debate. 'The FT has thought for many years that the solution for the world is that there should be no law. I think exactly the opposite.'
There's nothing wrong with national stereotypes, Sarko, but get them right, death of my life and the sacred blue. The notion that the FT is a doctrinally capitalist newspaper is so far off the mark that it's hard to know where criticism should begin. Since at least the early 1980s, the FT has been a corporatist paper of the Centre-Left, occasionally pro-business, but never pro-market. It opposed Margaret Thatcher's economic reforms, taking its hostility so far that it was, in effect, the only British newspaper openly to regret her victory in the Falklands War. Never mind Tony Blair; it backed Neil Kinnock in 1992. It was the single strongest supporter of ERM membership. It loudly applauded the monetary splurge which followed the credit crunch.
It is the most Euro-enthusiast daily newspaper in the country. Its ludicrous pronouncements on the success of the single currency could fill a book. Indeed, they have filled a book: Guilty Men by Peter Oborne. Here is one of my favourites:
With Greece now trading in euros, few will mourn the death of the drachma. Membership of the eurozone offers the prospect of long-term economic stability.
The paper was still hymning the praises of the euro as late as the second half of 2008, quite oblivious to how things were turning out. Its hostility to Eurosceptics and free-marketeers has deepened as they have been proved right (read, for example, these comments by Norman Davies.)
All newspapers are partial, of course. Everyone has a point of view. But the FT is unique in combining a tone of Olympian authority with quite naked partisanship. One of my earliest blogs here concerned an especially egregious example of its double standards on the EU
In short, the FT's position is the precise opposite of what Sarko thinks. Far from wanting to make the Continent more like Britain, it wants to make Britain more like the Continent - where, of course, most of its readers live and work.
That Sarko regards the pink paper as scarily Right-wing tells us quite how far from the European mainstream his own views are. The truth is that France faces a choice between two socialists. Both favour a command economy, a measure of protectionism, entrenched entitlements ('les acquis sociaux'), deeper European integration, and a dirigiste state. No wonder they argue so fiercely about immigration: that's virtually the only area where they disagree. Bonnet blanc et blanc bonnet, as they say in France. Tweedle-Dum and Tweedle-Dee.
Daniel Hannan is a British writer and journalist, and has been Conservative MEP for South East England since 1999. He speaks French and Spanish and loves Europe, but believes that the EU is making its constituent nations poorer, less democratic and less free. He is the winner of the Bastiat Award for online journalism.
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Here's the video Ed Schultz won't want you to see: THIS is what libs do when losing RFRA debate (and their minds)
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Into the fire?
Hacked again? Labor Dept. economist who claimed Christians vote for Nazis vanishes from Twitter
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2011 Kelley Fox Pinot Noir Mirabai
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Item #54718
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- Size: 750ml
- Type: Red Wine
- Varietal: Pinot Noir
- Country: United States
- Region: Oregon, Willamette
"Tart-edged, juicy fresh cherry and red currant, are steeped with pits, seeds and grapefruit rind and tinged with white pepper for an incisive, invigoratingly piquant, and exhilaratingly refreshing performance that has much of non-malo white wine character – as well as, to be sure, much that's uniquely Pinot – about it. The saline savor and bursting finishing intensity left my salivary glands in a prolonged state of palpitation. This extremely energetic and athletically lean Pinot should be fascinating not to mention stimulating to follow through at least 2022, and quite possibly well beyond." Reviewed by: The Wine Advocate - 92pts
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Spring Break 2015
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Located in the C-Store and GUC Simply-To-Go Coolers!
Try all 4 flavors! More Details Here
Monday: Oatmeal Raisin CookieTuesday: Cinnamon Crunch MuffinWednesday: Blueberry MuffinThursday: BrownieFriday: Cookies More information here!
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Registering and signing in allows you to interact with Campus Dining Services the way you want.
You can even use an ID you may already have - including Google, Yahoo, and more!
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Below are top resources on SparkPeople for Gluten Free Pizza.
It's blamed for a host of ailments: headaches, digestive distress, weight gain, poor immune function, hormonal disruption, and even behavioral problems in children. But does gluten, the natural-occurring protein found in wheat, barley, rye and so... Read more
Pasta is such a versatile food, it's no wonder it's so popular. A survey conducted by the National Pasta Association found that 77% of Americans eat pasta at least once per week. Used as a side dish or main entree, eaten hot or cold, topp... Read more
Greek yogurt is a staple for most healthy eaters--and for good reason. Even the fat-free varieties are thick and tangy with a luxurious texture. The yogurt also has twice the protein as regular yogurt. Beyond eating it plain or with granola and berri... Read more
It's 6 o'clock. Your guests should be arriving in less than an hour. Then your friend calls. Guess who's coming to dinner? Her new boyfriend, who's a vegetarian.
One night at the dinner table, your teenage daughter announce... Read more
Who doesn't like pizza? Nearly every mouth waters at the thought of sweet tomato sauce, tangy toppers, and that rich golden-brown crust, baked to perfection. This combination food can be a healthy choice, filled with complex carbohydrates, B-vi... Read more
For convenience products, anything labeled "gluten free" won't have wheat, but you still have to check for corn. Rice and other g-free grains like quinoa and oats. Greek yogurt/other dairy.... Read more
Really having a taste for pizza right now! Someone talk me out of going out and buy a slice. I packed baked tilapia for lunch, but mistakenly forgot my sides (broccoli and brown rice). sign...... Read more
Download the songza app! You can pick a playlist based on your mood:) It's free and no ads between songs. You need a WiFi or data connection where you workout though... Read more
I would only count NONSTARCHY veggies as "free". Fruit has naturally occurring sugar, and therefore more calories than you think (especially bananas). Starchy veggies (potatoes) break down into glucose (sugar) when digested and should be counted.... Read more
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Just found out two of their cereal are gluten free. YEA... Read more
This gluten free granola is very good as a snack or cereal.... Read more
If you're a vegetarian, vegan, semi-vegetarian, or just interested in a cruelty-free lifestyle, join us here! Get tips for making the transition, dining out, cooking and more.... Read more
In March, I ran a half marathon with a friend whose 6-year-old-son has Celiac Disease. We ran to benefit Team Gluten Free, a fundraising program that provides a simple way for recreational athletes to raise awareness about this disease. Since my... Read more
Editor's Note: According to the Celiac Disease Foundation, 1 in 133 Americans are affected by this ailment, which causes them to fall ill if they come in contact with even a trace amount of gluten, the protein found in wheat, barley, and rye. Abbie R... Read more
Crispy Thin Crust (Gluten Free) Pizza Crust Recipe - I am going make this for lunch tomorrow to double check my measurements (I'm terrible for not writing things down) and to add pictures.
Blend flours, sugar and gelatin together in a small bow... Read more
I made gluten free pizza dough, topped with Furmanos tomato sauce and fresh mozzarella! It took only 20 minutes to make and 15 minutes to bake! Even my fiancé loved it! :)... Read more


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Fox Lane High School Alumni
Amy Wolfson
Class of 1978
Valerie Mitchell Wallin
Class of 1964
Bill Viola
Class of 1975
Class of 1965
The alumni of Fox Lane in Bedford, New York are encouraged to use this site to relive their time in high school by sharing with former students and teachers of Fox Lane High School. Fox Lane High School alumni can relive their experiences from high school by sharing memories and pictures, reconnecting with those alumni listed, searching for former students and more. If you are a former student of Fox Lane High in Bedford, New York, register now to add your name.


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Melanie White | July 1, 2013 | Comments
Saatchi & Saatchi brought home 37 Cannes Lions at the Cannes Lions festival this year, with Saatchi & Saatchi LA winning gold awards in PR and Promo for its Toyota - Tundra Space Shuttle Endeavour campaign.
Saatchi & Saatchi brought home 37 Cannes Lions at the festival this year, with Saatchi & Saatchi LA winning gold awards in PR and Promo for its Toyota - Tundra Space Shuttle Endeavour campaign. The campaign involved a Toyota Tundra truck towing the Endeavor space shuttle across the 405 in Los Angeles to the California Science Center in downtown LA.
ClickZ interviewed John Lisko, executive communications director, and Margaret Keene, executive creative director, at Saatchi & Saatchi LA during the festival to learn about the campaign and how they continue to help their clients connect with consumers in the new age of digital.
"We've been working with Toyota since Toyota came to the United States and we've had a long-standing relationship and it's been a really special relationship and it's allowed us to do the kind of work that's led to [these] campaigns," says Lisko.
"When the agency industry unbundled in the '90s, Toyota made a decision to not follow the trends but instead stick with the integrated model, which we all know that's what everybody's looking to have today. And what we've been able to do at Saatchi is continue to hire the right talent to be able to develop the work, so it's not just television or it's not just a banner ad, or just a search campaign or a mobile campaign, but it's what's the right idea to connect with the customer," continues Lisko.
The festival proved that more and more companies are thinking outside of the box.
"Nowadays you've got to have thousands and thousands of elements for a campaign and you have to create a giant bucket of content that can live anywhere on any platform at any time, and the more people you have very close to you, the quicker you can pull it off," says Keene.
"The exciting thing too is that digitally and socially it's becoming so artful as it progresses. So if you have a great idea, you have all these amazing platforms to make these beautiful pieces…you can create something gorgeous on Tumblr, you can create just a tiny little GIF on Cinemagram; there's so many cool things that you can create. The more places to get your idea across in the most creative ways, the better. If you're an idea-focused agency it's just like a Wonderland," says Keene.
Want to learn more?
Attend ClickZ Live New York March 30 - April 1. With over 15 years' experience delivering industry-leading events, ClickZ Live brings together over 60 expert speakers to offer an action-packed, educationally-focused agenda covering all aspects of digital marketing. Register today!
Melanie White is the Editor of ClickZ, where she has worked since July 2012. White has been with Incisive Media (ClickZ's parent company) since 2009 where she was Deputy Editor/ US Editor for one of the financial risk management titles, International Custody and Fund Administration (later Custody Risk).
In addition, White worked on FX Week where she was a Senior Reporter. She has also worked and contributed to a number of other titles, including The Accountant, International Accounting Bulletin, the New York Post, Independent Magazine (UK), as well as the broadcast title Sunday Live with Adam Boulton at Sky News.
Mar 30-Apr 1, 2015
June 23-25, 2015
July 9, 2015
August 10-12, 2015
September 8-10, 2015
Hong Kong, May 5-6, 2015
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May 6, 2015
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CTSA Funding Information
The CTSA program provides critical resources and support needed to strengthen the entire spectrum of our nation's clinical and translational research enterprise. Funded institutions provide core resources, essential mentoring and training, and opportunities to develop innovative approaches and technologies designed to re-engineer existing capabilities. Program support also fosters collaborations to improve the quality, safety, efficiency and speed of clinical and translational research.
Funding Announcements
Current Opportunities
There are no open CTSA funding opportunities at this time. Information about future opportunities will appear on this page.
NCATS intends to publish several CTSA solicitations in spring 2015 for Trial Innovation Centers (NOT-TR-15-001), Recruitment Innovation Centers (NOT-TR-15-003), Pre-applications for Collaborative Innovation Awards (NOT-TR-15-005) and Collaborative Innovation Awards (NOT-TR-15-006).
View all of NCATS' current funding opportunities.
Expired Announcements
These now-expired funding announcements include details on the application process, eligibility and associated timelines for the program:
RFA-TR-14-009: Clinical and Translational Science Awards (U54)
NOT-TR-14-013: Notice of Corrections to RFA-TR-14-009 "Clinical and Translational Science Award (U54)"
NOT-TR-14-012: Notice of Change in the Application Due Date in RFA-TR-14-009 "Clinical and Translational Science Award (U54)"
Research Performance Progress Reports
NIH Guide notice, NOT-OD-15-014, requires that all grant progress reports for the CTSA UL1, KL2 and TL1 mechanisms be submitted electronically using the Research Performance Progress Report (RPPR) format. Please visit the NIH RPPR website for an overview and technical assistance for preparing and submitting reports. NCATS also has prepared specific guidance for CTSAs and frequently asked questions. Download the Oct. 23, 2014, webinar archive on this topic or read the transcript.
Related Links
Questions about RPPR submission
CTSA Funding News
NCATS intends to publish new funding opportunities in early 2015. See the notices below for details:
- NOT-TR-15-001: Trial Innovation Centers for the CTSA Network
- NOT-TR-15-003: Recruitment Innovation Centers for the CTSA Network
- NOT-TR-15-005: Pre-Applications for Collaborative Innovation Awards
- NOT-TR-15-006: Collaborative Innovation Awards
Notice of Proposed Rulemaking
HHS and NIH take steps to enhance transparency of clinical trial results.


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Department of History and Social Sciences
Everyone should read this article. It will just make you feel better.
Milk link for Zambia
1) Scripture of the week:
What does the Lord require of us?
Some elections are better than others...2 Peter 1:10
2) ANG Fun Links:
Unit Three Judicial and Elections
The Supremes:
Articles about two very different and very interesting people -
Justices Antonin Scalia and Ruth Bader Ginsberg
*Possibly the best one yet: http://baseball.oyez.org/ruready.html (Supreme Court Baseball!)
An interesting article on the size of the SCOTUS docket.
Here's a nice link to sections of Justice Harlan's dissenting opinion in Plessy.
A good set of discussions of Landmark Cases.
Here's a timely article by Justice Clarence Thomas.
"It so happens that everything that is stupid is not unconstitutional."
Justice Antonin Scalia
What if there is a tie in the Electoral College?
Purple America from Robert Vanderbei
One state, two state, red state, blue state: The Map
Dr. Seuss political cartoons
RealClearPolitics Polling Data for junkies like me...
Campaign finance - Who's raised what - Money
Pew Center article on info sources for voters.
We have much to be grateful for, and much to learn,
Here are the required texts for my courses.
American National Government students (POLS 205): The Spring 2015 syllabus is online. The Spring 2015 week by week schedule is also available.
State and Local students (POLS 353): Here is the Spring 2015 syllabus. The Spring 2015 Schedule is here.
Public Administration students (POLS 304): Here is the Fall 2014 syllabus. Here is the Fall 2014 schedule.
Public Policy students (POLS 306): Here is the Spring 2014 syllabus. Here is the Spring 2014 schedule.
Syllabus for POLITICAL SCIENCE 451 SUPERVISED INTERNSHIP/LEGAL PRACTICUM
The Library of Congress' Thomas (Congressional Info) - excellent link
Make-up tests will be given in my choice of essay or original format. Make-up tests are only available for excused absences.
And in other news, plagiarism is bad...
This page was last updated on 03/23/15.


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The magnet for the camshaft position sensor may fall out of its mount and damage the synchronizers. This causes long crank times when starting the engine and may cause the Check Engine Light to illuminate. If this happens, both the magnets and the synchronizers need to be replaced.
Problems for specific Mercury Sable years:
Car problem reports
Problem with your car? See what our experts say or submit your own.
Repairpal verified 2003 Mercury Sable problems
Engine Oil Pan Gasket May Leak
The engine oil pan gasket can develop a leak. Leaking oil may accumulate on the exhaust system resulting in a burning smell. Replacing the gasket should correct this leak.
79 Reports
Trunk Will Not Latch Closed
The electric trunk latch solenoid can get stuck in the open position making it so the trunk will not latch closed. The diagnosing technician should verify correct electrical connection at the solenoid and check for correct cable routing. The trunk latch most commonly will need to be replaced.
6 Reports