text:
College News
St. John Fisher College Breaks Ground for New Science Building
Earlier today, St. John Fisher College officials broke ground on the College's much anticipated Integrated Science and Health Sciences Building, slated to open in fall 2015. The new building is part of the College's Building for the Future initiative.
Dr. Donald Bain, President of the College, was joined by Vic Salerno '66, Chair of the Board of Trustees; members of the College's administration; science faculty; and students. Also present were Lieutenant Governor Bob Duffy; Senator Joseph Robach; Senator Ted O'Brien; Assemblyman Mark Johns; and representatives from the Finger Lakes Regional Economic Development Council, the Empire State Development Corporation, and the Kilian J. and Caroline F. Schmitt Foundation, all of whom are helping to support the building project. The George I. Alden Trust is also a partner.
"The College has experienced tremendous growth in the sciences, in fact, we have seen our enrollment increase threefold in the natural sciences in the last several years," said President Bain. "We recognize that in order to build for the future, we must expand our infrastructure of laboratories, classrooms, and collaborative learning spaces. And this new building will afford our students an opportunity to participate in even more vibrant and relevant programs, ultimately giving them not only a degree, but a very competitive edge as well."
In the past seven years, the number of nursing, biology, and chemistry majors has nearly doubled and the College has hired 13 new undergraduate science faculty members. The College currently produces approximately 106 math, science, and technology graduates, as well as 164 undergraduate nurses. In the master's and doctoral programs, the Wegmans School of Nursing produced a total of 44 graduates this year, while the Wegmans School of Pharmacy doctoral program produced 76 pharmacists. Approximately 77 percent of college graduates in science and nursing end up working in the region and New York State. In addition, the number of students participating in research courses in the areas of biology, chemistry, or science scholars has increased from 80 students to 105 students from 2009 to 2014, a 31% increase.
The College is building the $14 million academic facility, and investing $2.4 million into the renovation of the existing Skalny Science Center. While the new building is expected to be ready in 2015, the Skalny Science Center renovation should be complete by fall 2016.
With 31,000 square feet, and a U.S. Green Building Council LEED-certified design, the state-of-the-art building will include: two 100-seat flexible learning spaces; teaching laboratories for general chemistry, biochemistry, and physical chemistry; a lab prep room; breakout space for student collaboration; cross-disciplinary research space; two multipurpose labs and core facilities for tissue culture, nanobiology, and aquatic research; additional meeting spaces; and faculty offices.
Empire State Development President, CEO, and Commissioner Kenneth Adams said, "Congratulations to St. John Fisher College on its groundbreaking. This building will provide students with a new educational haven where they can build the skill sets necessary to excel in key growth industries."
Rendering provided by LaBella Associates.
Learn more about the Integrated Science and Health Sciences Building.
Latest College News Stories
- Students Plan 5K in Honor of Pharmacy Dean
- Fisher Students Earn Accolades at Annual Marketing Conference
- Hooding and Awards Ceremony Recognizes Doctoral Graduates at Fisher Extension Site
- Fisher Student's Passion for Airplanes Takes to New Heights
- Grant from Canandaigua National Bank & Trust Funds School of Business Scholarship
- College to Host First-Ever American Studies Undergraduate Research Conference
- Countdown to Commencement: Aidan Evans
- Preventing Youth Violence in Rochester Focus of Annual Trovato Lecture
- Jill Knittel '94, '03 (MBA) Honored as St. John Fisher College's Outstanding Accounting Alumnus of the Year
- Service-Learning Project Exposes PR Students to City Life
- Countdown to Commencement: Adrienne Aldridge-Kiner
- St. John Fisher College Names 7th President
- Kocher Wins Community Service Award
- Comedy Improv Competition Raises Funds for Gilda's Club
- Go Green during Fisher's Recycling Drive and Sustainability Fair


text:
We scoured the planet for the world's leading experts on mobile marketing, and for two days in NYC they'll gather together and unlock the secrets to transforming your business. Visionaries from Adidas, Samsung, Kraft Foods, P&G, and others, join together with a Pulitzer Prize winning author and agency experts to bring you SM2, the most important and only official mobile marketing event of Advertising Week. Check out the full SM2 agenda here, but don't delay in registering for this transformational event.
View Full Article in:http://www.mmaglobal.com/events/sm2/2012/register?WT_mc_ID=SM2smartbrief
Published in Briefs:

subset: commoncrawl


text:
politics: An explanation of Net Neutrality
Just this week, the Federal Communications Commission determined they had the authority, under Title II of the Communications Act of 1934 (which was created to regulate the telephone system), to regulate the Internet service provider industry. This is what has been called "Net Neutrality."
I have long supported one particular aspect of President Obama's original proposal for Net Neutrality ...
general: It's all downhill from here
Yesterday, I paid a visit to my father-in-law, who is also my audiologist, to make some adjustments to the programming of my hearing aids. I asked him if he could perform a new hearing test for me and generate a new audiogram since it's been a couple of years since I've had one done. We did that and I guess I was pretty dismayed, but not necessarily surprised, to see the results.
My ...
general: Thoughts on treating hearing loss
Most who know me know I've lived with moderate to severe hearing loss. I've worn hearing aids for 36 years and have gotten by quite well, functioning sufficiently in the world of school, career, and family.
My hearing loss has gotten gradually worse over the years, however. What started as a 45-50 dB loss in both ears when I was a child has become a 65-75 dB loss, possibly worse. A 100 ...
general: Book Review: "Dreamers and Deceivers" by Glenn Beck
Does Glenn Beck write his own books? I doubt it's possible. I believe his role is more like that of a film director or even a producer. With Miracles and Massacres and his latest offering Dreamers and Deceivers, I believe he picked which stories were to be told, what details were to be emphasized, and what the overall effect on the reader was to be.
diabetes: Book Review: "Think Like a Pancreas" by Gary Scheiner
I just finished reading Think Like a Pancreas by Gary Scheiner, a certified Diabetes educator and owner of Integrated Diabetes Services, a firm of Diabetes clinicians who all have Diabetes themselves and work to help their clients improve their ability to live with the ...
diabetes: Taking more aggressive action to combat post-prandial spikes
I've been reading the book Think Like a Pancreas by Gary Scheiner and I've found it is quite interesting and informative. I think any adult Type-1 Diabetic or caregiver of a Type-1 Diabetic would benefit from the information in the book.
I'll be posting a full review of the book in the next couple of weeks after I finish it.
One thing, however, ...
general: Fozzolog update and Livefyre comments
The Fozzolog was offline for a couple of months after I had Bluehost reinstall by VPS as a generic CentOS 7 host instead of a cpanel "enhanced" CentOS 6 host.
The delay was perpetuated by the fact I had to build and install dozens of Perl modules needed to run the Fozzolog which are not available through standard CentOS 7 repositories.
Now that the blog is back ...
politics: My review of the film 'America: Imagine The World Without Her'
Tonight, I attended a screening of America: Imagine The World Without Her at the Draper, UT Cinemark theater. Accompanying me were my wife and two of our children (10 and 13).
The theater the film was shown in was a small theater that ...
general: How I met my wife
In November 1993, I was a student at Utah State University studying Computer Science. I had attended USU since Spring 1990 with the exception of a couple of quarters I spent working full-time.
general: Finding better tools for managing T1D
In case you weren't aware, I'm a PWD (person with Diabetes) and was diagnosed with Type-1 Diabetes in November 2000. So, thirteen years ago, and change.
In the time I've been a diabetic, I've tested my blood glucose levels, sometimes several times a day, and I've injected myself with insulin with each meal and basal insulin every night before I go to bed.
Doctors have a way to ...
general: Book Review: "The Art of Being Unmistakable" by Srinivas Rao
I took my daughter to the hospital today so she could get an medicine infusion that she needs every eight weeks because of a chronic condition. These infusion sessions usually last about three hours of so, so I decided to read something ...
politics: Carefully considering the opt-in-for-porn proposal
There is a petition hosted at the WhiteHouse.gov website asking that Internet service providers provide a mechanism whereby users must "opt-in" if they want to access pornographic content on the Internet.
politics: Thanks Mike Lee rally
I attended a rally yesterday in South Jordan to thank US Senator Mike Lee for his work fighting Obamacare and standing up for strong liberty-oriented principles.
tech: Extending software collections
Recent Red Hat Developer Blog articles have explained what Software Collections are, what they're good for, and how you can leverage them to easily enhance your development environment leveraging the latest and greatest versions of your favorite programming languages and relational database backends.
But the software collection packages available for each language comprise only a subset of what is available — usually the core and some popular additions. Until that day when repositories have sprung up with all the additional SCL builds of libraries, modules, extensions to your language collection, you'll need to build those yourself.
general: New blogging platform
I have finally moved the Fozzolog away from MovableType to... what? WordPress? Heck, no!
The Fozzolog is now (again) powered by a blogging platform created with mine own hand: Fozzolog4. ...


text:
When I'm not in the mood to cook (and yes, that happens), our dinner often looks something like this. While there are a lot of salads on this blog, I probably don't post as many kale salads as I actually consume. I love them because they're hearty and filling and are pretty much a blank canvas for any seasonal vegetable. Plus, they're great to pack away for lunch the next day.
Kale might be "so last year," but it'll always have a special place in my heart.
This is a basic recipe that you can customize however you like – I like to serve this with soup or sometimes with a piece of salmon on top. You can get creative with what you mix in – I often add a little feta cheese, roasted sweet potatoes, chickpeas and/or a scoop of hummus or cashew cream. The options are endless.
Roast your cauliflower until it's browned and caramelized on the edges. Massage your kale with olive oil, salt, and citrus. I like to squeeze a bit of lemon and orange – I think the tangy/sweet combo helps to offset the bitterness of the kale. I usually don't bother to make a separate "dressing," I just mix everything together in one bowl. Taste and adjust from there…


text:
For more than 20 years, Consumerist reader Carl has been flying on Southwest Airlines, and he's been a frequent customer of the carrier for around 15 years. [More]
Southwest Helps Out Longtime Customer Even Though It Didn't Have To
8 Above-And-Beyond Customer Service Stories From Consumerist Readers
Not so long ago, in a fit of pleasantness, we asked readers to write in with stories of companies and employees who had gone above and beyond in providing customer service. We're happy to say we drastically underestimated how many of you would respond. [More]
JetBlue Employee Saved Our Family Vacation After We Booked Tickets For The Wrong Month
Back in September, the K. family were planning their end-of-year getaway from New York to Florida. But only days before they were set to travel to warmer climes, the Ks realized they had made a huge goof that could cost them a lot of money. [More]
Kmart Tracks Down Reader After 2-Day Shipping Became 2-Week Shipping, Tries To Help
You may remember reader Linda, who ordered a computer from Kmart with 2-day shipping as a Christmas gift for her mother. Kmart's idea of "2-day shipping" that they charge extra for turned out to be "2-week shipping" once they actually got around to shipping the computer. That wouldn't be so bad if it weren't, you know, a Christmas gift, and if Kmart planned to ship it before December 24th. Based on the information in the post, the nice people at Kmart's executive customer relations department tracked Linda down, which is impressive and only a little bit unnerving. [More]
Sam's Club Reinstates Oversold Black Friday Orders, Makes Up To Sad Customers
Remember the Black Friday deal at Sam's Club where too many orders came in for the best deals, and there wasn't enough merchandise to fill them all? Well, Sam's Club is doing the right thing for those customers, reinstating the canceled orders and even sending free memberships and gift cards to customers who went and found the same items elsewhere. [More]
ING Direct Customer Caught In Debit Card Fraud Gray Zone
Most cases of ID theft and credit/debit card fraud involve the thief going whole-hog on the victim's account, spending as much as they can in a very short period of time. But what happens when that fraudulent activity isn't enough to set off alarm bells at the bank? [More]
T-Mobile Saves The Day When Samsung Won't
We often write about oddball, 1-in-1,000 customer service horror stories. For most consumers, their feelings about a company is often related to how it responds to everyday concerns and complaints. [More]
Bus Driver Finds Elderly Woman's $500K Cash In A Shopping Bag & Turns It In
We've often mused about what we'd do if we were to stumble on a whole lot of cash, seemingly without any owner to claim it. Maybe sneak a few bills? Quietly tuck it all away and pretend like it never happened? We couldn't, we just couldn't. And when a bus driver in Vienna found a shopping bag filled with 390,000 euros ($509,700) in cash, he did the right thing, too. [More]
My Mom Ordered One iPad And Best Buy Sent Five
Alexa's boyfriend got an iPad for Christmas from his mother. Well, that's not quite true. His mother ordered one iPad, and had it shipped to him. What arrived on their doorstep was a very large and heavy box that was big enough to hold five iPads. Because it did. [More]
How Dave's Coffee Saved One Customer's Thanksgiving
When Consumerist reader and New Jersey resident Brian lost power for nearly a week following Hurricane Sandy, he also thought his plans to craft some homemade coffee ice cream for Thanksgiving had gone kaput too. [More]
LG Admits Smart TV Without Working Remote Isn't Very Smart, Offers To Replace It
Earlier this week, we shared the story of reader Michael, who bought a pricey 3-D smart television from Amazon. His family thought it was pretty awesome until the set's remote would no longer work. A few different repair teams weren't able to make the TV and its remote work together permanently. Would he be left with a great big TV set that he couldn't even use to watch YouTube videos? Sure, that's a first world problem, but consumers deserve to get what they pay for. We posted about Michael and his TV. Coincidentally, after the post went up LG contacted him with a resolution. [More]
Apple Takes Back Wi-Fi-Sabotaging MacBook, Replaces It With Shiny New One
Micahel's new Macbook had a very unusual flaw. Whenever it was connected to his home network, it would take out his modem. Unfortunately, it didn't take the whole Apple Store's network down, so he wasn't able to replicate the problem for the Geniuses. After five trips and a variety of repairs, Apple finally gave up…and gave him a brand new MacBook. [More]
Comcast (Eventually) Buys Customer New TV After Her Cable Box Goes BOOM!
A California woman says she was just watching TV one night when her Comcast cable box suddenly exploded, followed by her TV shutting itself off, never to turn on again. [More]
Complaint About Disappointing Noodle Bowl Results In Bounty Of Noodles For Customer
Consumerist reader Scott is a big fan of the noodle bowls made by the folks at Nongshim America. But when he recently went to heat up a bowl, he was let down by the half-full product he encountered. The way the company responded certainly made up for the disappointment. [More]
Jack The Cat Found After Two Months In JFK Airport
Before the flight to his new home in California, Jack the cat escaped from his travel carrier and disappeared into John F. Kennedy Airport. The airline organized searches and put out food, and animal lovers all over the world helped in any way they could, from performing their own searches of the airport and nearby neighborhoods to getting word out to employees of nearby businesses and other airlines. We're happy to report that Jack has been found. In two months, he apparently never left the airport. [More]
Bad Charge at Macy's Leads to Good Deed
Chris sends in a happy story about Macy's messing up, then going above and beyond to not only remedy the problem, but assuage its effects. His letter details exceptional service, but not surprising for a department store counter known for high levels of customer care.


text:
You're little lemons in a race with a souped-up Corvette
from Joell Ortiz – Battle Cry Lyrics on Genius
A lemon is a bad car, usually bought at a used car lot. He compares the other rappers to these bad cars, whereas Joell is a stylish, powerful, and ballin' sports car.
To help improve the quality of the lyrics, visit Joell Ortiz – Battle Cry Lyrics and leave a suggestion at the bottom of the page


text:
Book review: Laura Ingalls Wilder book explores her career as a farm journalist
Remember the days before computers?
Hard to, isn't it? They seemed so Jetsons thirty years ago, but computers are as common as TVs in most homes now. Come to think of it, your grandparents might remember the days before TV.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at email@example.com and we can help you.


text: I ended up in Max a couple times. Good food, cheap drinks and the staff made me feel at home. I stayed and hung out, played some pool and as soon as I get back to Kuta I will make this a regular place to be. Plus little cutie mascot monkey"Maxx" is always fun to see :)


text:
Griak Invitational an eye-opener for young cross country runners
Competing at one of the largest cross country meets in the country was an eye-opening experience for the New Richmond and Somerset squads on Saturday.
Both teams were part of the incredible field of runners at the Roy Griak Invitational hosted by the University of Minnesota. Ten college and high school races were held over the course of the day at the Les Bolstad Golf Club at the university.


text:
Constanza Kaliks
Born in 1967 in Chile, Constanza Kaliks grew up and lived mostly in Brasil. Constanza completed her studies of Mathematics in São Paulo, and went on to be mathematics teacher at the Escola Rudolf Steiner in São Paulo for 19 years. There she was also a teacher in the Waldorf Teacher training. Constanza has a Masters Degree in Education and recently completed her Ph.D on Nicolaus of Cuse. She is married with two children. Since January 2012, Constanza has been the Leader of the Youth Section at the Goetheanum and was recently nominated to the Vorstand of the Goetheanum.


text:
Berger, Ova
Crystal Berger and Joshua Ova, both Bismarck, N.D., were married June 29 at the Church of Saint Anne, Bismarck.
Parents of the couple are Connie and Marc Berger and Amy and Mark Roberts, all Bismarck, Natalie and Kevin Ova, Gackle, N.D., and Stacy Ova, Jamestown.
Get the full story
Subscribe or Log In
Are you a newspaper subscriber but you don't have a Digital Access account yet? Activate your account.
You will need your subscription account number and phone number. Not sure if you have an account? Call 701-252-3120 and we can help you.


text:
Image Unavailable
- Sorry, this item is not available in
- Image not available
- To view this video download Flash Player
|List Price:
|$4.00 & FREE Shipping on orders over $35. Details
|You Save:
|$10.99 (73%)
Product Details
Would you like to update product info or give feedback on images?
The time and emotion invested watching Junebug is lost in a matter of seconds.
Unless you're a film student, and feel like you just HAVE to figure this movie out, you'll find "Junebug" sparse, enigmatic... and, in the end, unsatisfactory viewing.
This slice-of-life story takes us into the everyday life of the Johnsten family as seen through the eyes of an outsider.
I love this movie. I have watched it several times. It's a good movie to watch on a snowy day. A cup of hot chocolates goes good with it.Published 26 days ago by Lana sStanforth
The movie that made Amy Adams' a star is indeed special. It reminds me of "Old Joy" in it's pacing, choice of shooting locations, and near-absence of dramatic questions. Read morePublished 1 month ago by Ricardo Mio
There are great movies, those in which every element (or almost) is fantastic. There are movies with a good script, cinematography, a good director... Read morePublished 4 months ago by Crazyforbooks
I barely made it to just over 8 minutes of the movie. Too many vulgar cartoon images being portrayed as some kind of art (NOT). Really? Who watches this garbage?Published 5 months ago by dreamconscious
Sweet, simple, yet complicated version of the south --home.Published 7 months ago by Kevin Fletcher


text:
This Content Component encountered an error
Focus on
Economic Indicators September 2014
We offer major economic figures.
Management Bulletin September 2014
This publication contains current information on relevant management issues.
Related links
TMT Predictions
Deloitte, a has recently released its 2014 Global TMT Predictions in which it highlights the adoption of wearable technologies.
Digital Marketing in 2014
In its recently published "Digital Marketing 3.0" report, Deloitte highlights the emergence and growth of digital media and devices as companies invest billions of dollars in this type of strategy
Legal News
It is a monthly publication by Deloitte in which you will find the latest legal and tax
Official Gazette
Here is a detail of the main laws, decrees, resolutions and agreements published weekly


text:
NCAAB Basketball - Preview
|Manhattan Jaspers vs. Niagara Purple Eagles
The Manhattan Jaspers and the Niagara Purple Eagles will both be trying to pick up a win on Saturday when they battle at Gallagher Center. Manhattan lost its last outing, a 64-60 result against Canisius on January 17. They covered in that game as a 7.5-point underdog. Last time out for Niagara, they were an 87-64 winner as they battled Siena at home. They covered in the match as a 13.5-point favorite. Manhattan:
Team record: 5-12 SU, 8-7 ATS
is 1-5 SU in its last 6 games when playing on the road against Niagara
When playing on Saturday are 4-6
Team record: 10-8 SU, 6-7-1 ATS
Current streak: won 3 straight games.
is 5-0 SU in its last 5 games at home
When playing on Saturday are 5-5
Manhattan home to Loyola, Friday, January 25
Niagara at Siena, Friday, January 25


text:
Posts filtered on Category
Options abound for Astros' 2012 starting rotation
General manager Jeff Luhnow's acquisition of former Red Sox farmhand and major league dabbler Kyle Weiland as part of his first move has given the Astros 10 starting pitchers on their 40-man roster, and manager Brad Mills has said he's going to give Weiland a chance in spring training. [Read More]
Would a Mat Latos type deal have made sense for the Astros?
Could the Mat Latos-to-Cincinnati deal easily have been a Mat Latos-to-Houston deal? Now, before you shout me down, let's take a look. First, Latos is only 24 years old, earned $460,000 in 2011, won't even sniff arbitration until 2013 and won't be a free agent until at least 2016. At 24, he's already established himself […] [Read More]
Astros hold one of best lefthanders on market in Wandy
By midday Wednesday — the Astros' final full day at baseball's winter meetings — the logjam had begun to break apart in the team's quest to trade off some of its remaining high salaries. [Read More]
LRW: Seriously, what's your beef with moving to the AL?
Look, there's nothing worse than being kicked to the curb after 50 years. Thanks for the memories. But let's have this conversation on substance. What is it that you don't like most about the Astros' move to the American League? [Read More]
Roger Clemens to pitch again?
According to Puerto Rico's El Nuevo Dia newspaper, Roger Clemens has shown interest in wanting to pitch for the same winter league team his son Koby will be playing for. For more, check out the original article here . [Read More]
Heck has escaped criticism, but is he getting a free pass?
As dave b suggests, there has been much grace and little scrutiny for Heck, who — like Wade — has had four drafts to build on. How long does it take to build a scouting department and start to see fruit through the draft? How many good players is enough to say an organization is on the right track? [Read More]
Forget the hot stove, Astros' top prospects finally creating some buzz
Since it appears the Astros will not have much of a hot stove season, let's turn our attention in a different direction. For the last decade or so, being a top prospect in the Astros' organization hasn't meant too much. At least not to people outside the Astros' organization. Now, after a handful of trades over […] [Read More]
Looking back at the suck-the-life-out-of-you trades for Berkman and Oswalt
It's been only a few years since we were speculating whether Roy Oswalt or Lance Berkman were Hall of Fame candidates. [Read More]
Nolan, Gerry, Larry: You have to wonder if Drayton ever wondered
They say we shouldn't cry over spilled milk. But a guy can dream, even in retrospect, right? Especially after the Tampa Bay Rays stormed back to the playoffs, and the Rangers continue to defy the odds, you have to wonder what if. And you know Drayton McLane has had those fleeting thoughts, now perhaps called […] [Read More]
Which Astros' greats would you build around for the future?
With last year's trades of Lance Berkman and Roy Oswalt, and the continued fire sale this year with Hunter Pence, Michael Bourn and Jeff Keppinger, there isn't much of a nucleus to build around for the next Astros' contender. Oh, you can argue that Bud Norris, J.D. Martinez or Jose Altuve and Jimmy Paredes are […] [Read More]
Show More


text:
New to Papercrete, have made many hypertufa's ???
I have made many hypertufa's pots, but I am looking to make some Papercrete pots. I have perused many of the tutorials on the making of these and I am wondering if they are as durable as the hypertufa's pots when complete. Have read to let them sit uncovered and out of rain/moisture to cure? If there is anyone that could give me some information of their experience with these, it would very much appreciated.
Hi, I've done papercrete , yes it's as dureable as the tufa. Because it absorbs so much water in the paper you do have to leave it to dry in a dry place, and I would seal it after. I found it harder to mix together and would say a mixer would make it easier than by hand.
Why are you wanting to use this mix, are you trying to go thinner walls or lighter pots?
We met at the Nanoose plant swap in the fall, I've been working on my first spring project building a wire armiture for a water feature. The same technique I used for the easter island head I think you liked. You are welcome to come by and learn that technique if you like.
I would very much like to learn the technique that you use, Cindy.
I had seen pots done in Papercrete and the concept of lighter in weight was one plus, as I want it for indoors. Sometimes I get a idea as to what I want for a pot and trying to find it in a retail location just does not work.
Thanks Cindy,
Hey Rick
Yes they are very durable, very lightweight and look so cool. That's true about curing- you just wait till they dry out completely. I treat mine with liquid glass to make them waterproof.
Just recently I also made a Japanese lantern (looks crude but it is my first trial)
Those are amazing. What a wonderful job.
What is the brand name of the " liquid glass" product you speak of and what is it sold for?
Have you used the White Portland cement for your pots and lantern?
Did you have to treat them before planting up or just leave for a while?
Sorry for all the questions.
Thaks :)
I cannot give you any brand name 'cos I live in Germany. I guess you will find it in any shop/warehouse with building materials- ask for sodium silicate.
I used normal gray Portland cement, it's the paper that gives it the colour. Liquid glass makes it a bit darker.
I treated them with silicate first and a wall sealant to make them 100% waterproof, left them to dry out and planted. No idea if it's gonna affect the roots, we'll see.
I forgot to mention about the use of sodium silicate. But you should check yourself e.g. on wikipedia. They use it in many lines of business- form making fizzy drinks, storing eggs to stopping radioactive leakage in Fukushima.
But not diluted may burn your skin just like cement so remember to wear some rubber gloves, and goggles in case it may splash into your eyes.
Oh and if you mix it with cement it will set quicker ;)


text:
Give Now
The new rule would only be in place long enough until an administrative decision with the rule of law could be adopted.
The forecast for May was more than actual intake, but the yearly predictions have been fairly accurate.
The state required colleges to start charging the higher rates last year.
Assembly passes law in response to court ruling restricting use of force against illegal police entry.
Refunds expected this year, but Assembly changes level of revenue surplus that triggers refunds after 2012.
Some legislators say it's possible the ban won't get passed this year.
The smoking ban received the most attention in the Indiana legislature this week. The General Assembly also passed bills on stage regulations and police entry.
The Indiana Senate passed a statewide smoking ban Wednesday, but there's still work to be done before the bill can reach the governor.
Talk of the statehouse this week included Fort Wayne Republican Representative Bob Morris' statements about the Girl Scouts.
A creationism bill and legislation that would require drug testing for welfare recipients died in the legislature this week.


text:
OP Senior Member
Thanks Meter: 4,633
7,101 posts
Join Date:Joined: Jun 2010Donate to Me
I recently sold this phone and went to factory reset. no problem. However, i forget i deleted the STOCK home app. THere is no launcher on the device so LG Setup Wizard simply crashes when finished setting it up. There is NO ADB since the setting has been erased. I need to re-enable it in settings but can't get that far since LG Setup Wizard keeps crashing..
I think i'm screwed.. what a stupid way to brick..
Device is: LG Optimus L9 P769 T-Mobile variant. Thanks guys!
Last edited by elesbb; 7th July 2014 at 09:24 PM.


text:
Are you Margaret R Spitz?Claim your profile
Publications (542)3375.88 Total impact
[Show abstract] [Hide abstract]
ABSTRACT: Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 × 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.The American Journal of Human Genetics 03/2015; 96(3):487-97. DOI:10.1016/j.ajhg.2015.01.011 · 11.20 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Recently the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also the approach used to perform these evaluations. Some critics have claimed that IARC Working Groups' failures to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans. The authors of this paper are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We have examined here criticisms of the IARC classification process to determine the validity of these concerns. We review the history of IARC evaluations and describe how the IARC evaluations are performed. We conclude that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various discipline and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed. The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public's health.Environmental Health Perspectives 02/2015; DOI:10.1289/ehp.1409149 · 7.26 Impact Factor
Article: THE AUTHORS REPLY.
[Show abstract] [Hide abstract]
ABSTRACT: PARK2, a gene associated with Parkinson disease, is a tumor suppressor in human malignancies. Here, we show that c.823C>T (p.Arg275Trp), a germline mutation in PARK2, is present in a family with eight cases of lung cancer. The resulting amino acid change, p.Arg275Trp, is located in the highly conserved RING finger 1 domain of PARK2, which encodes an E3 ubiquitin ligase. Upon further analysis, the c.823C>T mutation was detected in three additional families affected by lung cancer. The effect size for PARK2 c.823C>T (odds ratio = 5.24) in white individuals was larger than those reported for variants from lung cancer genome-wide association studies. These data implicate this PARK2 germline mutation as a genetic susceptibility factor for lung cancer. Our results provide a rationale for further investigations of this specific mutation and gene for evaluation of the possibility of developing targeted therapies against lung cancer in individuals with PARK2 variants by compensating for the loss-of-function effect caused by the associated variation. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.The American Journal of Human Genetics 01/2015; DOI:10.1016/j.ajhg.2014.12.016 · 11.20 Impact Factor
Article: Informed Genome-Wide Association Analysis With Family History As a Secondary Phenotype Identifies Novel Loci of Lung Cancer[Show abstract] [Hide abstract]
ABSTRACT: Lung cancer is the leading cause of cancer death worldwide. Although several genetic variants associated with lung cancer have been identified in the past, stringent selection criteria of genome-wide association studies (GWAS) can lead to missed variants. The objective of this study was to uncover missed variants by using the known association between lung cancer and first-degree family history of lung cancer to enrich the variant prioritization for lung cancer susceptibility regions. In this two-stage GWAS study, we first selected a list of variants associated with both lung cancer and family history of lung cancer in four GWAS (3,953 cases, 4,730 controls), then replicated our findings for 30 variants in a meta-analysis of four additional studies (7,510 cases, 7,476 controls). The top ranked genetic variant rs12415204 in chr10q23.33 encoding FFAR4 in the Discovery set was validated in the Replication set with an overall OR of 1.09 (95% CI = 1.04, 1.14, P = 1.63 × 10(-4) ). When combining the two stages of the study, the strongest association was found in rs1158970 at Ch4p15.2 encoding KCNIP4 with an OR of 0.89 (95% CI = 0.85, 0.94, P = 9.64 × 10(-6) ). We performed a stratified analysis of rs12415204 and rs1158970 across all eight studies by age, gender, smoking status, and histology, and found consistent results across strata. Four of the 30 replicated variants act as expression quantitative trait loci (eQTL) sites in 1,111 nontumor lung tissues and meet the genome-wide 10% FDR threshold. © 2015 WILEY PERIODICALS, INC.Genetic Epidemiology 01/2015; DOI:10.1002/gepi.21882 · 2.95 Impact Factor
Article: CYP2A6 Reduced Activity Gene Variants Confer Reduction in Lung Cancer Risk in African American Smokers - Findings from Two Independent Populations.[Show abstract] [Hide abstract]
ABSTRACT: We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African American smokers, a high-risk population. Previously, we found that CYP2A6, a nicotine/nitrosamine metabolism gene, was associated with lung cancer risk in European Americans, but smoking habits, lung cancer risk, and CYP2A6 gene variants differ significantly between European and African ancestry populations. Herein, African American ever-smokers, drawn from two independent lung cancer case control studies, were genotyped for reduced activity CYP2A6 alleles and grouped by predicted metabolic activity. Lung cancer risk in the Southern Community Cohort Study (n = 494) was lower among CYP2A6 reduced versus normal metabolizers, as estimated by multivariate conditional logistic regression (OR = 0.44; 95% confidence interval [CI] = 0.26 to 0.73) and by unconditional logistic regression (OR = 0.62; 95% confidence interval [CI] = 0.41 to 0.94). The association was replicated in an independent study from MD Anderson Cancer Center (n = 407) (OR = 0.64; 95% CI = 0.42 to 0.98), and pooling the studies yielded an odds ratio of 0.64 (95% CI = 0.48 to 0.86). Exploratory analyses revealed a significant interaction between CYP2A6 genotype and sex on the risk for lung cancer (Southern Community Cohort Study: P=.03; MD Anderson: P=.03; Pooled Studies: P=.003) with a CYP2A6 effect in men only. These findings support a contribution of genetic variation in CYP2A6 to lung cancer risk among African American smokers, particularly men, whereby CYP2A6 genotypes associated with reduced metabolic activity confer a lower risk of developing lung cancer. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: email@example.com 11/2014; 36(1). DOI:10.1093/carcin/bgu235 · 5.27 Impact Factor
Epidemiology (Cambridge, Mass.) 11/2014; 25(6):934-935. DOI:10.1097/EDE.0000000000000183 · 6.18 Impact Factor
Article: The Next Generation of Large-Scale Epidemiologic Research: Implications for Training Cancer Epidemiologists[Show abstract] [Hide abstract]
ABSTRACT: There is expanding consensus on the need to modernize the training of cancer epidemiologists to accommodate rapidly emerging technological advancements and the digital age, which are transforming the practice of cancer epidemiology. There is also a growing imperative to extend cancer epidemiology research that is etiological to that which is applied and has the potential to affect individual and public health. Medical schools and schools of public health are recognizing the need to develop such integrated programs; however, we lack the data to estimate how many current training programs are effectively equipping epidemiology students with the knowledge and tools to design, conduct, and analyze these increasingly complex studies. There is also a need to develop new mentoring approaches to account for the transdisciplinary team-science environment that now prevails. With increased dialogue among schools of public health, medical schools, and cancer centers, revised competencies and training programs at predoctoral, doctoral, and postdoctoral levels must be developed. Continuous collection of data on the impact and outcomes of such programs is also recommended.American Journal of Epidemiology 09/2014; 180(10). DOI:10.1093/aje/kwu256 · 4.98 Impact Factor
Article: The Cytokinesis Blocked Micronucleus Assay as a Strong Predictor of Lung Cancer: Extension of a Lung cancer risk prediction model.[Show abstract] [Hide abstract]
ABSTRACT: Background:There is an urgent need to improve lung cancer outcome by identifying and validating markers of risk. We previously reported that the cytokinesis-blocked micronucleus assay (CBMN) is a strong predictor of lung cancer risk. Here we validate our findings in an independent external lung cancer population and test discriminatory power improvement of the Spitz risk prediction model upon extension with this biomarker. Methods:1,506 participants were stratified into a test set of 995 (527 cases /468 controls) from MD Anderson Cancer Center and a validation set of 511 (239 cases / 272 controls) from Massachusetts General Hospital. An epidemiologic questionnaire was administered and genetic instability was assessed using the CBMN assay. Results:Excellent concordance was observed between the two populations in levels and distribution of CBMN endpoints [binucleated-micronuclei (BN-MN), binucleated-nucleoplasmic bridges (BN-NPB)] with significantly higher mean BN-MN and BN-NPB values among cases (P<0.0001). Extension of the Spitz model led to an overall improvement in the AUC (95% CI) from 0.61 (55.5 - 65.7) with epidemiological variables to 0.92 (89.4 - 94.2) with the addition of BN-MN endpoint. The most dramatic improvement was observed with the never smokers extended model followed by the former and current smokers. Conclusions:The CBMN assay is a sensitive and specific predictor of lung cancer risk and extension of the Spitz risk prediction model led to an AUC that may prove useful in population screening programs to identify the "true" high risk individuals. Impact: Identifying high-risk subgroups that would benefit from screening surveillance has immense public health significance.Cancer Epidemiology Biomarkers & Prevention 08/2014; 23(11). DOI:10.1158/1055-9965.EPI-14-0462 · 4.32 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Background: Smoking experimentation in Mexican American youth is problematic. In light of the research showing that preventing smoking experimentation is a valid strategy for smoking prevention, there is a need to identify Mexican American youth at high risk for experimentation. Methods: A prospective population-based cohort of 1179 adolescents of Mexican descent was followed for 5 years starting in 2005-06. Participants completed a baseline interview at a home visit followed by three telephone interviews at intervals of approximately 6 months and additional interviews at two home visits in 2008-09 and 2010-11. The primary end point of interest in this study was smoking experimentation. Information regarding social, cultural, and behavioral factors (e.g., acculturation, susceptibility to experimentation, home characteristics, household influences) was collected at baseline using validated questionnaires. Results: Age, sex, cognitive susceptibility, household smoking behavior, peer influence, neighborhood influence, acculturation, work characteristics, positive outcome expectations, family cohesion, degree of tension, ability to concentrate, and school discipline were found to be associated with smoking experimentation. In a validation dataset, the proposed risk prediction model had an AUC of 0.719 (95% confidence interval, 0.637 to 0.801) for predicting absolute risk for smoking experimentation within 1 year. Conclusions: The proposed risk prediction model is able to quantify the risk of smoking experimentation in Mexican American adolescents. Impact: Accurately identifying Mexican American adolescents who are at higher risk for smoking experimentation who can be intervened will substantially reduce the incidence of smoking and thereby subsequent health risks.Cancer Epidemiology Biomarkers & Prevention 07/2014; 23(10). DOI:10.1158/1055-9965.EPI-14-0467 · 4.32 Impact Factor
Article: Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33[Show abstract] [Hide abstract]
ABSTRACT: Genome-wide association studies (GWAS) have mapped risk alleles for at least ten distinct cancers to a small region of 63,000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (ASSET) across six distinct cancers in 34,248 cases and 45,036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single nucleotide polymorphisms (SNPs): five in the TERT gene (region 1: rs7726159, P=2.10x10-39; region 3: rs2853677, P=3.30x10-36 and PConditional=2.36x10-8; region 4: rs2736098, P=3.87x10-12 and PConditional=5.19x10-6, region 5: rs13172201, P=0.041 and PConditional=2.04x10-6; and region 6: rs10069690, P=7.49x10-15 and PConditional=5.35x10-7) and one in the neighboring CLPTM1L gene (region 2: rs451360; P=1.90x10-18 and PConditional=7.06x10-16). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele specific effects on DNA methylation were seen for a subset of risk loci indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.Human Molecular Genetics 07/2014; DOI:10.1093/hmg/ddu363 · 6.68 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Wingless-type protein (Wnt)/β-catenin pathway alterations in non-small cell lung cancer (NSCLC) are associated with poor prognosis and resistance. In 598 stage III-IV NSCLC patients receiving platinum-based chemotherapy at the MD Anderson Cancer Center (MDACC), we correlated survival with 441 host single-nucleotide polymorphisms (SNPs) in 50 Wnt pathway genes. We then assessed the most significant SNPs in 240 Mayo Clinic patients receiving platinum-based chemotherapy for advanced NSCLC, 127 MDACC patients receiving platinum-based adjuvant chemotherapy and 340 early stage MDACC patients undergoing surgery alone (cohorts 2-4). In multivariate analysis, survival correlates with SNPs for AXIN2 (rs11868547 and rs4541111, of which rs11868547 was assessed in cohorts 2-4), Wnt-5B (rs12819505), CXXC4 (rs4413407) and WIF-1 (rs10878232). Median survival was 19.7, 15.6 and 10.7 months for patients with 1, 2 and 3-5 unfavorable genotypes, respectively (P=3.8 × 10(-9)). Survival tree analysis classified patients into two groups (median survival time 11.3 vs 17.3 months, P=4.7 × 10(-8)). None of the SNPs achieved significance in cohorts 2-4; however, there was a trend in the same direction as cohort 1 for 3 of the SNPs. Using online databases, we found rs10878232 displayed expression quantitative trait loci correlation with the expression of LEMD3, a neighboring gene previously associated with NSCLC survival. In conclusion, results from cohort 1 provide further evidence for an important role for Wnt in NSCLC. Investigation of Wnt inhibitors in advanced NSCLC would be reasonable. Lack of an SNP association with outcome in cohorts 2-4 could be due to low statistical power, impact of patient heterogeneity or false-positive observations in cohort 1.The Pharmacogenomics Journal advance online publication, 1 July 2014; doi:10.1038/tpj.2014.21.The Pharmacogenomics Journal 07/2014; DOI:10.1038/tpj.2014.21 · 5.51 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Lung cancer causes more deaths worldwide than any other cancer. In addition to cigarette smoking, dietary factors may contribute to lung carcinogenesis. Epidemiologic studies, including the environment and genetics in lung cancer etiology (EAGLE), have reported increased consumption of red/processed meats to be associated with higher risk of lung cancer. Heme-iron toxicity may link meat intake with cancer. We investigated this hypothesis in meat-related lung carcinogenesis using whole genome expression. We measured genome-wide expression (HG-U133A) in 49 tumor and 42 non-involved fresh frozen lung tissues of 64 adenocarcinoma EAGLE patients. We studied gene expression profiles by high-versus-low meat consumption, with and without adjustment by sex, age, and smoking. Threshold for significance was a false discovery rate (FDR) ≤0.15. We studied whether the identified genes played a role in heme-iron related processes by means of manually curated literature search and gene ontology-based pathway analysis. We found that gene expression of 232 annotated genes in tumor tissue significantly distinguished lung adenocarcinoma cases who consumed above/below the median intake of fresh red meats (FDR = 0.12). Sixty-three (∼28%) of the 232 identified genes (12 expected by chance, P-value < 0.001) were involved in heme binding, absorption, transport, and Wnt signaling pathway (e.g., CYPs, TPO, HPX, HFE, SLCs, and WNTs). We also identified several genes involved in lipid metabolism (e.g., NCR1, TNF, and UCP3) and oxidative stress (e.g., TPO, SGK2, and MTHFR) that may be indirectly related to heme-toxicity. The study's results provide preliminary evidence that heme-iron toxicity might be one underlying mechanism linking fresh red meat intake and lung cancer. © 2013 Wiley Periodicals, Inc.Molecular Carcinogenesis 07/2014; 53(7). DOI:10.1002/mc.22006 · 4.27 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Inflammation is a facilitating process for multiple cancer types. It is believed to affect cancer development and progression through several etiologic pathways including increased levels of DNA adduct formation, increased angiogenesis and altered anti-apoptotic signaling. This review highlights the application of inflammatory biomarkers in epidemiologic studies and discusses the various cellular mediators of inflammation characterizing the innate immune system response to infection and chronic insult from environmental factors. Included is a review of six classes of inflammation-related biomarkers: cytokines/chemokines, immune-related effectors, acute phase proteins, reactive oxygen and nitrogen species, prostaglandins and cyclooxygenase-related factors, and mediators such as transcription factors and growth factors. For each of these biomarkers we provide a brief overview of the etiologic role in the inflammation response and how they have been related to cancer etiology and progression within the literature. We provide a discussion of the common techniques available for quantification of each marker including strengths, weaknesses and potential pitfalls. Subsequently, we highlight a few under-studied measures to characterize the inflammatory response and their potential utility in epidemiologic studies of cancer. Finally, we suggest integrative methods for future studies to apply multi-faceted approaches to examine the relationship between inflammatory markers and their roles in cancer development.Cancer Epidemiology Biomarkers & Prevention 06/2014; 23(9). DOI:10.1158/1055-9965.EPI-14-0064 · 4.32 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and 38,295 controls for follow-up. We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10−20) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10−13). We also showed an association between common variation at 3q28 (TP63, rs13314271, OR = 1.13, P = 7.22 × 10−10) and lung adenocarcinoma that had been previously reported only in Asians. These findings provide further evidence for inherited genetic susceptibility to lung cancer and its biological basis. Additionally, our analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data.Nature Genetics 06/2014; 46(7). DOI:10.1038/ng.3002 · 29.65 Impact Factor
Article: Inflammation-Related Genetic Variations and Survival in Patients With Advanced Non–Small Cell Lung Cancer Receiving First-Line Chemotherapy[Show abstract] [Hide abstract]
ABSTRACT: Background:accurate prognostic prediction is challenging for advanced-stage non-small cell lung cancer (NSCLC) patients.Methods:we systematically investigated genetic variants within inflammation pathway as potential prognostic markers for advanced-stage NSCLC patients treated with first-line chemotherapy. A discovery phase in 502 patients and an internal validation in 335 patients were completed at MD Anderson Cancer Center. External validation was performed in 371 patients at Harvard University.Results:a missense SNP (HLA-DOB:rs2071554) predicted to influence protein function was significantly associated with poor survival in the discovery (HR:1.46, 95% CI:1.02-2.09), internal validation (HR:1.51, 95% CI:1.02-2.25), and external validation (HR:1.52, 95% CI:1.01-2.29) populations. KLRK1:rs2900420 was associated with a reduced risk in the discovery (HR:0.76, 95% CI:0.60-0.96), internal validation (HR:0.77, 95% CI:0.61-0.99), and external validation (HR:0.80, 95% CI:0.63-1.02) populations. A strong cumulative effect was observed for these SNPs on overall survival.Conclusions:Genetic variations in inflammation-related genes could have potential to complement prediction of prognosis.Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 22 April 2014; doi:10.1038/clpt.2014.89.Clinical Pharmacology & Therapeutics 04/2014; 96(3). DOI:10.1038/clpt.2014.89 · 6.85 Impact Factor
Article: Abstract A106: Optimal strategies for selecting samples for sequencing families with a common cancer: The Genetic Epidemiology of Lung Cancer Consortium.Cancer Prevention Research 01/2014; 5(11_Supplement):A106-A106. DOI:10.1158/1940-6207.PREV-12-A106 · 5.27 Impact Factor
Article: Smoking Experimentation, Moderate-to-Vigorous Physical Activity, and associated Psychosocial and Demographic Correlates among Mexican Origin Youth01/2014; DOI:10.6000/ijipem/2014/1
Article: Genome-wide scan of 29,141 African Americans finds no evidence of selection since admixture[Show abstract] [Hide abstract]
ABSTRACT: We scanned through the genomes of 29,141 African Americans, searching for loci where the average proportion of African ancestry deviates significantly from the genome-wide average. We failed to find any genome-wide significant deviations, and conclude that any selection in African Americans since admixture is sufficiently weak that it falls below the threshold of our power to detect it using a large sample size. These results stand in contrast to the findings of a recent study of selection in African Americans. That study, which had 15 times fewer samples, reported six loci with significant deviations. We show that the discrepancy is likely due to insufficient correction for multiple hypothesis testing in the previous study. The same study reported 14 loci that showed greater population differentiation between African Americans and Nigerian Yoruba than would be expected in the absence of natural selection. Four such loci were previously shown to be genome-wide significant and likely to be affected by selection, but we show that most of the 10 additional loci are likely to be false positives. Additionally, the most parsimonious explanation for the loci that have significant evidence of unusual differentiation in frequency between Nigerians and Africans Americans is selection in Africa prior to their forced migration to the Americas.
Article: Genetic Variation in the PNPLA3 Gene and Hepatocellular Carcinoma in USA: Risk and Prognosis Prediction[Show abstract] [Hide abstract]
ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic with high prevalence in Western countries. Genome-wide association studies had reported that a variation in the patatin-like phospholipase domain containing 3 (PNPLA3) gene is associated with high susceptibility to NAFLD. However, the relationship between this variation and hepatocellular carcinoma (HCC) has not been well established. We investigated the impact of PNPLA3 genetic variation (rs738409: C>G) on HCC risk and prognosis in the United States by conducting a case-control study that included 257 newly diagnosed and pathologically confirmed Caucasian patients with HCC (cases) and 494 healthy controls. Multivariate logistics and Cox regression models were used to control for the confounding effects of HCC risk and prognostic factors. We observed higher risk of HCC for subjects with a homozygous GG genotype than for those with CC or CG genotypes, the adjusted odds ratio (OR) was 3.21 (95% confidence interval [CI], 1.68-6.41). We observed risk modification among individuals with diabetes mellitus (OR = 19.11; 95% CI, 5.13-71.20). The PNPLA3 GG genotype was significantly associated with underlying cirrhosis in HCC patients (OR = 2.48; 95% CI, 1.05-5.87). Moreover, GG allele represents an independent risk factor for death. The adjusted hazard ratio of the GG genotype was 2.11 (95% CI, 1.26-3.52) compared with CC and CG genotypes. PNPLA3 genetic variation (rs738409: C>G) may determine individual susceptibility to HCC development and poor prognosis. Further experimental investigations are necessary for thorough assessment of the hepatocarcinogenic role of PNPLA3. © 2013 Wiley Periodicals, Inc.Molecular Carcinogenesis 11/2013; 52(S1). DOI:10.1002/mc.22057 · 4.27 Impact Factor
Top Journals
Baylor College of Medicine
Houston, Texas, United States
- Dan L. Duncan Cancer Center
International Agency for Research on Cancer
Lyons, Rhône-Alpes, France
- Genetic Epidemiology Group
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
- Department of Epidemiology
University of Toronto
Toronto, Ontario, Canada
- Department of Pharmacology and Toxicology
Dartmouth College
Hanover, New Hampshire, United States
- Geisel School of Medicine
Molecular and Cellular Biology ProgramSeattle, Washington, United States
Harvard Medical School
Boston, Massachusetts, United States
- Department of Medicine
Karmanos Cancer InstituteDetroit, Michigan, United States
Washington University in St. LouisSan Luis, Missouri, United States
Keele UniversityNewcastle-under-Lyme, England, United Kingdom
University of Texas Southwestern Medical Center
Dallas, Texas, United States
- Hamon Center for Therapeutic Oncology Research
United States ArmyWashington, West Virginia, United States
National Institutes of Health
Bethesda, MD, United States
- Division of Cancer Epidemiology and Genetics
University of California, San FranciscoSan Francisco, California, United States
National Cancer Institute (USA)
Bethesda, MD, United States
- Division of Cancer Epidemiology and Genetics
University of HoustonHouston, Texas, United States
University of PennsylvaniaFiladelfia, Pennsylvania, United States
Nanjing Medical University
Nanjing, Jiangsu Sheng, China
- Department of Epidemiology and Biostatistics
University of California, Los Angeles
Los Angeles, CA, United States
- Department of Epidemiology
Louisiana State University in ShreveportShreveport, Louisiana, United States
Henry Ford HospitalDetroit, Michigan, United States
Icahn School of Medicine at Mount SinaiManhattan, New York, United States


text:
38 years of experience
Accepting new patients
Brawley, CA 92227 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. William Creighton:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
The overall average patient rating of Dr. William Creighton, Allergist & Immunologist, Pediatrician is Good.
Specialties & Research
Dr. William Creighton, MD is board certified in Allergy & Immunology and Pediatrics.
- He has special expertise in 1 area:
- Allergy
Education & Awards
Dr. Creighton graduated from University of Alabama at Birmingham.
Dr. Creighton has 1 hospital affiliations:
- Pioneers Memorial Healthcare District
Similar doctors nearbySearch All Similar Doctors
- Additional Information
- Dr. William Dodson Creighton MD is a male Allergist & Immunologist, has 38 years of experience and practices in Allergy & Immunology and Pediatrics.
- Where does Dr. William D. Creighton practice?
- Dr. William Creighton has 2 office locations.
Dr. William Creighton practices Allergy & Immunology and Pediatrics near Brawley, CA.
Additional practice locations include: El Centro, CA.
See Brawley Allergists and Brawley Pediatricians.


text:
31 March 2015
April 1 changes to help families get ahead
Prime Minister John Key says Paid Parental Leave, the parental tax credit, the minimum wage and Superannuation will increase, while average ACC levies will fall, and more people will be helped in to home ownership from tomorrow.
"The National-led Government has focused on ensuring gains from our growing economy flow through to families and these measures demonstrate that."
A range of Government policies come into force from April 1 including:
- The Government's new HomeStart scheme to help around 90,000 Kiwis into their first home over the next five years.
- Paid Parental Leave to increase by two weeks to 16 weeks – and by another two weeks from 1 April next year.
- The parental tax credit to rise from $150 a week to $220 a week, and the entitlement increases from eight weeks to 10 weeks.
- Average ACC levies paid by employers and self-employed people will fall to 90 cents per $100 of liable earnings, down from 95 cents.
- New Zealand Superannuation to increase by another 2.07 per cent – meaning it has increased by 31 per cent since April 2008. This is double inflation in that time.
- The adult minimum wage to rise from 14.25 an hour to $14.75 an hour – a 3.5 per cent increase.
"These measures build on the policies we've implemented over the past seven years to help New Zealanders get ahead," Mr Key says.
"Looking ahead, there are more policies designed to help families which take effect from 1 July. These include children under 13 having access to free GP visits and free prescriptions, and the average ACC levy for a private motor vehicle falling by around $135 a year."
"The Government's careful economic management is also helping New Zealand families in other ways. In 2014 we saw 80,000 new jobs created, and the average wage grew at 2.5 per cent compared with inflation of 0.8 per cent. The average wage is expected to increase by $6,500 to over $62,000 by the second half of 2018."
"The Government's responsible economic management is helping New Zealand families to get ahead."
28 March 2015
PM: Northland by-election result disappointing
Prime Minister John Key says he's disappointed National
has lost the Northland by-election but congratulates Winston Peters on
winning the seat.
"Mark Osborne is an outstanding candidate and he would've been a strong advocate for Northland in the National-led Government.
"By-elections are always tough and it was a unique set of circumstances that occurred in Northland that led to this result.
"However, Mr Peters ran a good campaign and I congratulate him on his win," Mr Key says.
"The Northland region has been struggling for decades and although we have been making progress, Northlanders have clearly told us they are not satisfied with the rate of progress and we understand that.
"I would like to assure Northlanders we're going to continue to work hard to deliver more progress. We plan to work hard to win the seat back in the general election in two and a half years," Mr Key says.
27 March 2015
PM to attend the Cricket World Cup Final
Prime Minister John Key will attend the final of the Cricket World Cup in Melbourne this weekend.
"I am delighted to be attending the final between New Zealand and Australia," says Mr Key.
"Our two countries have a special rivalry. Over the years we have been treated to some truly exceptional sporting clashes and I expect this one will be no different. I wish Brendon McCullum and the Black Caps all the very best."
Mr Key says New Zealand has been proud to co-host the tournament alongside Australia. The event has seen 49 matches played over 44 days, across 14 venues in New Zealand and Australia.
"It has been a great opportunity to showcase New Zealand to the world, with television audiences expected to exceed 1 billion people and international visitor numbers forecast to top 30,000.
"I would like to congratulate all the teams for what has been a tremendous tournament. I would also like to thank the many fans who have turned out in force to support their teams and all those who have worked to make the tournament such a success," says Mr Key.
Mr Key will leave on Saturday and return home on Monday.
Sports Minister Jonathan Coleman will also attend the final.Tweet
23 March 2015
NZ signs Free Trade Agreement with Korea
Prime Minister John Key says New Zealand's Free Trade Agreement (FTA) with Korea opens a new chapter in the two countries' relationship.
Mr Key and President Park Geun-hye of Korea witnessed the signing of the Agreement by Trade Ministers Tim Groser and Yoon Sang-jick in Seoul today.
"The Agreement shows the strength of the relationship between New Zealand and Korea. It symbolises our countries' commitment to economic openness and market integration in the Asia-Pacific region," says Mr Key.
"Korea is one of New Zealand's biggest and most important trading partners. This Agreement makes it easier for Koreans and Kiwis to do business with each other, and the removal of tariffs will benefit consumers in both countries.
"At the moment, New Zealand exports into Korea attract NZ$229 million a year in duties. Tariff reductions in the first year of the FTA alone will save an estimated NZ$65 million."
The Agreement now needs to be ratified by the New Zealand Parliament.
"We are keen for the Agreement to come into force this year," says Mr Key.
"With a population of over 50 million and as the 13th largest economy in the world, Korea is an attractive market for New Zealand exporters."
Notes for editors:
- Korea is New Zealand's sixth largest export destination for goods and services and our eighth largest import source, with total two-way goods trade of NZ$4 billion.
- Negotiations on the Agreement started in June in 2009 and concluded in November 2014.
- The Agreement was initialled on 22 December 2014. Initialling marked the end of the text's legal verification process.
- More information, including the full text of the Agreement, is available at korea.fta.govt.nz
23 March 2015
PM extends condolences at passing of Lee Kuan Yew
Prime Minister John Key has expressed his sincere condolences to the people of Singapore following the death of the nation's first Prime Minster, Mr Lee Kuan Yew.
"Mr Lee made an extraordinary contribution to Singapore, both as it found its way to independence in 1965 and in the 50 years since then," said Mr Key.
"A man of rare qualities, Mr Lee's courage, determination, commitment, character and ability made him a formidable leader who held the respect of Singaporeans and the international community alike."
Known as one of Singapore's founding fathers, Mr Lee guided the development of a country which has become a world leader. He was also instrumental in the establishment of the Association of South East Asian Nations, ASEAN, which has offered cohesion and stability in a diverse region.
"Mr Lee provided a unifying presence in his country since its creation as a state in 1965. His loss will be deeply felt by his family and the people of Singapore."
"I had the honour of meeting Mr Lee in 2007 during his last official visit to New Zealand. He was well known for his insights and foresight but what struck me most was his unwavering determination to see Singapore succeed."
"A powerful advocate for the region and supportive of New Zealand's role in South East Asia and the wider world, Mr Lee was a close and long-time friend of New Zealand," said Mr Key.Tweet


text:
Shop now and get Free Value Shipping on most orders over $49 to the contiguous 48 states, DC and to all U.S. Military APO/FPO/DPO addresses.
We want to ensure that making a return is as easy and hassle-free as possible! If for any reason you decide that your purchase just isn't for you, simply return the item within 30 days of receipt and we'll cover the cost of return shipping. Learn more about our Return Policy.
The Strong Leather Company Sb Fl 2r Bt 28 Lp-bb was introduced to be the perfect solution to make sure your pants continue to be up. Made employing many of the finest possible materials available, these Belts from Strong Leather Company will provide you with ages of beneficial use. Strong Leather Company has been in the belt market for an exceptionally long period of time, and the Strong Leather Company Sb Fl 2r Bt 28 Lp-bb is the result of their efforts to ensure you have the best trouser preserving system for the value. We have a lot of belts to choose between and our professional product experts are here to confirm that that you obtain the best one for all of your desires. For an ideal approach to keep your slacks from drifting down down, decide on the Strong Leather Company Sb Fl 2r Bt 28 Lp-bb.
Sb Fl 2r Bt 28 Lp-bb
Connect with OpticsPlanet
Become our fan, follow us, & subscribe for the latest updates and deals
Subscribe to our email list
Sign up and receive $5 Off and get exclusive access to promotions, sales
events, pre-order sales & more!
Contact Information
Toll-Free: 800-504-5897
Intl.: 847-513-6201
Fax: 847-919-3003
Email: email@example.com
Hours of Operation
7AM-8PM CST Mon-Fri9AM-5PM CST Sat-Sun
Our Guarantees


text:
Chateau De Chine Hotel Kaohsiung
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Continental Breakfast
- Room service
- Restaurant
- Free High-Speed Internet
- Business Services
- Fitness/Health center
Photos of Chateau De Chine Hotel Kaohsiung
Travelers also recommend:
TripAdvisor Reviews Chateau De Chine Hotel Kaohsiung
Travel Blogs from Kaohsiung
Back in Kaohsiung! Shing + Hong
... a different hostel this time. I did not want to go back to D'well again after telling Anne that I was leaving for sure that last time. I found a really cute little place close to Central Park station. I also made sure to book my hostel in Chiayi and did not want to wait last minute again.
I said my goodbyes to George and Claudia and then headed to the train station. I had a few hours before the train so I wandered around the city one last ...
Meeting Asta and Dada Kovid
... s place, you have to send a formal request (e.g., Click on the "STAY WITH ME" button). I have only messaged her so it was not a formal request. I did not do that with Che in Kaohsiung. He was more lax with the rules. I think to many Asta would not be described as the most pleasant person in the world. I knew that before even meeting her but I wanted to keep and open mind. Do not get me wrong I had a great time with her and would probably hang out ...
A Relaxing Day at a coffee shop
... had lots of seats and also many outlets where I can charge my phone and laptop. I spent most of the day there updating my blog and drinking tea. I really enjoyed doing nothing today and do not feel bad about it. There is still a lot that I want to see but I was in desperate need of a break.
I decided to go back to D'Well hostel since I thought it was excellent and clean and also all the other hostels around were more ...
BUDDHA Land
... had some good conversations with the people there. From all the conversations I have had with travelers and foreigners teaching English here, the consensus was that Kaohsiung was had a more relaxed vibe and people are more approachable than in Taipei. I totally agree. I am really enjoying my time in Kaohsiung. People are friendlier here; not that I had any bad experience in Taipei but it is definitely a different feel.
My First Couchsurfing Experience
... Science and Technology Museum. I checked out of the hostel but left my bag there so I would not have to carry it with me around the museum.
The museum was not far from Kaoshiung Main station but I opted to take the bus instead of walking since there was supposed to be rain the forecast. The exhibits ranged from the industrial history of Taiwan to healthy living and air navigation and aerospace. There was also a Disease Prevention Combat Camp, ...