text:
August 27, 1953 – March 22, 2015 Albert Lester Moon, 61, of Owens Cross Roads, passed away Sunday. Lester served as pastor and associate pastor at several local churches. He was preceded in death by father, Virgil Moon, mother, Jean Moon. Surviving are wife, Jerri Moon, son, Joseph Vasser, daughter, Michelle (Ragan) Self, son, Lee […]Continue reading
J.D. Webster
November 26, 1939 – March 21, 2015 J.D. Webster, 75, of New Hope, passed away Saturday March 21, 2015. He was born in Madison County on November 26, 1939 to James and Ruthie Webster. He was a member of Christ Church of Huntsville, AL. He served in the U.S. Army from 1962 – 1964. He […]Continue reading
Lucy Adams Whitaker
December 10, 1924 – March 9, 2015 Lucy Adams Whitaker, 90, of Grant, passed away Monday. Lucy was born at home on December 10, 1924 in the Nebo area of New Hope, AL to her parents Shelby and Sallie Jane Whitaker, and the fifth child out of a total of seven. She lived in Madison […]Continue reading
Malcolm D. Keel
November 2, 1941 – March 8, 2015 Malcolm D. Keel, 73, of Grant, passed away Sunday. Surviving are wife, Helen Keel, son, Johnathan (Aimee) Keel, granddaughter, Jenna Keel, sister, Kay Smith, step son, Billy Bennett, step son, Steven (Lisa) Bennett, step grandchildren, Brandy, B.J., Grant, Summer, Autumn, Wynter, 7 step great grandchildren, niece, Kelly Hopkins, […]Continue reading
Hannah Louise Maples Parks
September 22, 1921 – March 6, 2015 Hannah Louise Maples Parks, 93, of Grant, passed away Friday. Known as Gran Hannah and the "heart" of her family, she was loved and admired for her many talents, along with her strong will and beautiful heart. She tackled any situation head on and was a resourceful problem […]Continue reading
Robert Watts
May 28, 1931 – February 27, 2015 Robert Watts, 83, of Owens Cross Roads, passed away Friday. Mr. Watts was a U.S. Army veteran of the Korean War. He was preceded in death by father, James David Watts, mother, Maggie Lee Bradford Watts, daughter, Lisa Watts Baker, and wife, JoAnn Stephens Watts. Surviving are son, […]Continue reading
Jim Kilgore
January 15, 1926 – February 24, 2015 Jim Walter Kilgore, 89, of New Hope, passed away Tuesday. Visitation will be Friday 5:00 PM to 7:00 PM at New Hope Funeral Home. Services will be held at New Hope Funeral Home Chapel, Saturday at 11:00 am with Bro. Simon Mayo officiating.Continue reading
Martha Nell Harding Lankford
February 21, 1931 – February 23, 2015 Martha Nell Harding Lankford, 84, of Grant, passed away Monday. She was preceded in death by her beloved husband, Alfred (Red), parents, Clara and Moses Harding, sisters, Fay Harding Blackburn and Lucille Cryer Maples, brother, John Harding, Nephews Jimmy Blackburn, Ted Kennedy, and John Kennedy. Survivors include are […]Continue reading
Debbra "Deb" Childers
December 9, 1951 – February 23, 2015 Debbra "Deb" Childers, 63, of New Hope, passed away Monday. She was preceded in death by mother, Louise Levern Perkins, father, Virgil Ray Perkins. Surviving are husband, Sebourn Childers, daughter, Debbra Burk, son, Sebourn Childers, II, 4 grandsons, 1 granddaughter, sister, Regina Anderson, and sister, Judy Palmer. Visitation […]Continue reading
Larry Ray Williams
The funeral service for Larry Ray Williams will be delayed until Friday at 1pm. July 2, 1949 – February 21, 2015 Larry Ray Williams, 65, of Huntsville, passed away Saturday. He was preceded in death by father, Elmer Ray Williams, mother, Daisy Mable Williams, daughter, Melody Elaine Williams, siblings, Roy Lee Williams, Dorothy Groat, Lillie […]Continue reading


text:
Finding Source Line to Vavles
My existing valves have been leaking for quite a while and one is so bad it is now finally losing pressure and draining out the sprinkler heads. I'm going to replace all four (two for front, two for back yard), since three of them are original and 20 years old and one is 10 years old.
My first thought was "I need a master shutoff valve for these" since I can't find one and must close the household water main to work on them.
But I'm having trouble finding which one is the supply to the area.
Here is the pic of the valve area in backyard (the 3rd is the worst, shown with severed electrical to solenoid and cap removed):
Here are the lines to/from the area (located in the front yard, notice this is otherside of the same fence in both pics):
I have four (maybe 5) 1" lines going to the area but I can't tell which are supply or distribution -- in fact I'm confused why there would even that many in this spot. Two go to the front (where this pic is taken), so shouldn't there be only 3? Unless the backyard two also follow the front yard then make a U-turn and head back a few feet later.
Do I need to severe them all or dig out a whole lot more to verify where each one goes? Because all are touching, when I turn on the supply I can't tell by "feel" which one is flowing for which valve.
Or should I just toss out the whole idea of a master shutoff valve?
Here are the parts for the replacement project (only 1 of each item shown):
This is pretty much all that's needed (except tools), correct?
Thanks in advance.
Here is what I would do. First, locate main line valve by digging down around the valve manifold to expose the pipes(in pic #1). See the pipe that connects all the valves on the inlet side of the manifold; that is your mainline. Another method is to use a small metal pipe held in your fist(poor mans stethoscope) to listen to water moving through the pipes. Turn on each valve manually by turning the solenoid and listen(record what lines comes on with what valve). The line that always makes noise is the mainline. I would replace the whole manifold section. That is all the automatic valves and piping. I would use the the in-line auto-valves instead of the ones you in the pics. This change would decrease the height of your setup(make them invisible). Place the manifold and auto-valve in a irrigation box with lid 1/2" above the surface of the ground. Each in-line auto-valve should have unions on both sides for easy replacement. I would install a main shut off with a Vacuum Breaker that sits above the highest irrigation head. That would be the only visible part and give easy access to shutting off the irrigation system. If the controller is 10 years old or 20 yrs replace that as well. It is easy to do yourself and a good one costs about $50 for a 6-zoner. Good luck. JMHO Aloha
Thanks for the reply. I really do appreciate your assistance.
I'll try the metal pipe method today. Bare hands only didn't work, as the pipes are all touching each other.
Your suggestion to "replace it all" is exactly what I would've done on my own, had it been easier.
I should've been clearer, as I would've dug down by the 1st valve had it been easy enough. The 2nd picture above IS only about 1 foot away from the 1st valve, just the other side of the fence. The room shown in the pic #1 is the entirety of the room available. It is too tight to do any real work in there (even if I remove the junk shown). To the right is the house, to the left is the cement slab with a big shed, to the front is the fence with metal post topped off with cement running just underneath it!
It took over an hour to remove just 3" of rocks from around the valves; we didn't even make a dent in it.
You can't tell from the pics the whole area is very secluded so I don't care if it's ugly.
Question: Do the metal+pvc manifold lines need replacement every so often, just like the valves do?
If so, then I guess I'll bite the bullet and tear down the fence section and break the cement, in order to clear out the rocks and replace the manifold. The wiring is looking pretty old, too. Becomes a much bigger project at that point.
If the pipes rarely go bad, I guess I'll just skip the Master shut-off idea and replace the valves. I also have a new 6 zone auto-timer ready.
Does the last pic look like the only materials needed for a valve-only replacement?
I am glad you responded, here are some additional thoughts:
1.What is the distance between the concrete slab and house slab in the first pic?
2. Rent an electric spade with a shovel or point attachment. Or buy a long heavy steel pointed breaker bar. Both items will make short work of rocks around manifold.
3.This is an in-line autovalve. They are quite small compared to what you show in your last pic. This link is just a sample of the valve. Any brand will do. http://www.rainbird.com/homeowner/products/valves/CP-CPF.htm
4. If your manifold is started and ended with a pvc union-type coupling. Your system can be put together outside the hole and fitted in as one unit and screwed in place. Does take some planning though.
5. PVC pipe does get more brittle with age but if let completely undisturbed will last a very long time but if it not buried deep enough will be disturbed by moderate surface activity. Also internal shock from high velocity movement of water from high pressure can cause shock breakage over time.
6. I recommend a master shut-off valve with a vacuum break/backflow prevention device attached as you have shown in the last pic. You only need one per system if you only have one source.
7. Think about stacking of manifold lines on top of each other versus side by side if there is not enough room, aesthetics aside.
Just my humble opinion(JMHO). Aloha
If you're still around, I'm sorry I never responded .. I guess email notifications were off for that period b/c I never got a message.
I ended up just replacing two of the valves and still have not put in the master shutoff. But the pvc is showing more age and I'm replacing the shed next year so I'm saving your instructions for this fall.
Thanks so much for taking the time to help me.

subset: commoncrawl


text:
Posts filtered on Category
Salvage, resale & more
When we first featured BAW Resale and Interiors last January, their vintage-packed spot on Orleans Street was a small taste of things to come. Several months and a stocked warehouse later, BAW is serving up 15,000 square feet of salvage to Southeast Texas. The industrial downtown space is geared toward home interiors, but you can […] [Read More]
Hot Pick: Grandma's Basement Ladies' Holiday Party
Get in a little Christmas shopping — and stock your vintage arsenal for holiday party season — at a ladies' holiday shop-tacular at Grandma's Basement. Enjoy refreshments while you browse collections from Retreauxgirl, the Green Junque Monkey and Stellar Treasure. When: 6-9 p.m. Thursday Where: Grandma's Basement, 2406 Calder Ave., Beaumont Cost: No cover [Read More]
Invest in style
Dressing for our unpredictable fall and winter weather can be challenging, but the ever-so-versatile vest is here to help you layer and top off your looks. This beloved garment is picking up steam at boutiques, so I rounded up my favorite styles, from preppy to boho and luxe. Spending an evening in a toasty, crowded […] [Read More]
Paint the town glam
On Thursday night, Triangle Aids Network revisits Studio 54, the exclusive New York nightclub where glamour reigned supreme. This celebrity-filled spot boasted bold fashions during its run from 1977-1981, making this fundraiser an excellent occasion to dress on the wild side. Many styles made an appearance, but common disco-era elements are metallic hues, sequins and […] [Read More]
Last-minute costumes for people who just don't give a damn
Look, not everybody is on board with this whole annual socially mandated costume situation. Some of us happen to be crippled by the pressure to have an awesome costume. And some of us happen to just hate wearing things that aren't jeans. The truth of the matter is, it sucks to show up at a […] [Read More]
The Neon Gypsy's bohemian spirit
Neon letters and corrugated tin act as a radiant welcome to a funky business nestled along a tree-lined highway. The Neon Gypsy, "a vintage junk shop and boutique," has expanded its fashions since the store's February opening. With a spacious new location in the works, the future looks bright for this locally owned shop. From […] [Read More]
Hot Pick: Trade Days on the Avenue
Wander the antique shops on Port Neches Avenue, grab some food truck grub and check out recent progress on this sweet little avenue during the merchants' monthly Trade Days celebration. When: 10 a.m.-5 p.m. Saturday Where: Port Neches Avenue shopping district, Port Neches Cost: Free [Read More]
Dress for the fest
Art parties are an opportune time to tap into creative dressing and push the envelope. This weekend's interactive arts festival, Montage, will be no different. The Betty Greeenberg Center for Performing Arts will take on a festival atmosphere with theater troupes, costume competitions, regional artists, vendors and food. Although the costume competitions required entry prior […] [Read More]
Knit wit
When it comes to cozy fall dressing, knit pieces that pack a punch are a comfy way to make a statement while keeping things simple, especially when layering feels like a chore. Are you a denim gal? Pair this graphic pullover with your go-to jeans and call it a day. For something more fashion-forward, try […] [Read More]
Handmade First Thursday finds
Having one-of-a-kind goods sprinkled in your wardrobe adds a personal touch to your look. Handmade items often give back long after the purchase, and with festivals and reoccurring community events like First Thursday on Calder, there are opportunities to buy directly from an artisan, learn about the process and enjoy a unique piece. Brenda Ramsey […] [Read More]
Show More


text:
- Home
- →
- Occupations
- -
- Medical
Customer Reviews
There are no reviews for this product yet. Please share your thoughts on this product!
Sending the same ornament to different places? If you order more than one of an item and want them shipped to different addresses, please order them individually. We will ask you for the individual shipping addresses later in the ordering process.
Pharmacist Male Christmas Ornaments
Personalized Christmas Ornament
This pharmacist writes prescriptions with first hand knowledge of chemistry and makes sure that the combination of medications is safe and healthy for you. Get a personalized pharmacist ornament for a pharmacy school graduate or as a thank you gift to your local pharmacist for caring about you and your meds. This personalized pharmacy ornament gets personalized on the prescription pad with a name while in the other hand, this professional pharmacist holds your prescription. Wonderful keepsake for a medical professional or professor of pharmacology!
Material: Resin
Ornaments shown on our site are personalized, as examples only, so you can see where we put the words/names you give us. Some ornaments allow you to select hair or uniform color. If there is no color choice, it is not available on that particular ornament. We will do everything possible to catch any mistakes in spelling, etc., but are not responsible if we do as you request, and it is then not correct. The ornament you see above is the way it will look when you get it, except for the personalizing instructions you give us and any optional attributes you select.


text:
Shaker Aamer is not being held at Guantánamo Bay for anything he has done; he is a pawn in the power games of others.
The positions advocated in a recent essay in Foreign Affairs reflect how weak, incomplete and outdated US intelligence oversight is.
Andrew Lam is an editor with New America Media and author of Perfume Dreams: Reflections on the Vietnamese Diaspora, and East Eats West: Writing in Two Hemispheres. His latest book is Birds of Paradise Lost, a short story collection, was published in 2013 and won a Pen/Josephine Miles Literary Award in 2014.


text:
Gobble Up the Gables
Gobble up the Gables - restaurant week is back!
Coral Gables Restaurant Week
June 6-19
Restaurant week is back! From June 6-19, Coral Gables locals and visitors can enjoy prix-fixe three-course lunches & dinners at over two dozen restaurants. Participating restaurants include Anacapri on Ponce, Bangkok Bangkok, Caffe Abbracci, Gables Diner, Morton's The Steakhouse and Norman's 180. Prices and menus vary by restaurant, for a complete list, visit www.coralgablesrestaurantweek.com.
The fun kicks off June 2 with a Taste of the Gables featuring live DJ spinning, food & drinks. $25 in advance, $35 day of.
Quick Bites
- Michelle Bernstein's kitchen team comes together at new Michy's
- The List: Miami's best food with Barceloneta's Juliana Gonzalez
- The List: Top bites in Miami with Finka's Eileen Andrade
- Chef Danny Grant and John Kunkel's 50 Eggs part ways
- Guess where we're eating, win tickets to see Robert Irvine Live
- New Spanish restaurant Piripi to open March 30 in Coral Gables
- Taste of Tennis to pair pro players and Miami chefs
- Bombay Darbar moving to bigger space in Coconut Grove
- The List: Eating in Miami with Azul chef William Crandall
- Texas de Brazil, Basil Thai now open at Dadeland Mall


text:
Welcome to the College of Mount Saint Vincent, Class of 2019!
Congratulations on your acceptance to the College of Mount Saint Vincent. You have been selected for admission based on your exceptional academic history and your enormous potential to contribute to the College community. Over the next few months, your Admission Counselor will be available to assist you as you learn more about the College of Mount Saint Vincent, and determine if this is where you will be spending the next four years.
Submit your Enrollment Deposit
Access Your
Accepted Student Portal
Visit us on Accepted Student Day on Sunday, April 19, 2015!
Join us for our Accepted Student Day to learn what life is like at the Mount
and meet with faculty, coaches, administrators, and current and future students.
Register here
Admitted Student/Faculty Meet and Greet Events
As you weigh your different college options, we encourage you to visit campus to learn more about the excellent academic programs offered at the Mount, By interacting with our exceptional faculty members and students, we know you will see why the Mount is the best place to spend your college career! Meet and Greets with various departments are offered on the following dates:
- Business and Economics - Wednesday, March 11, 4:30 – 6:00 p.m.
- Nursing - Wendesday, March 25, 4:30 – 6:00 p.m.
- Natural Sciences - Thursday, March 26, 4:30 – 6:00 p.m.
To register for one of these events, click here.
Join the College of Mount Saint Vincent Class of 2019 Facebook Group!
Register Here | Incoming Freshman To-Do List | Important Deadlines | Important Phone NumbersIncoming Freshman To-Do List:
Join the Class of 2019 Facebook Group
Get to know your future classmates, learn about events on campus, meet current students, and get your questions answered. Click here to join
Submit New Standardized Test Scores and Mid-Year Grades
Have your senior mid-year grades and any updated SAT or ACT scores sent to the Office of Admission. It is important that you continue to apply yourself through the end of your senior year.
File for Financial Aid
Apply for financial aid by filling out the FAFSA (Free Application for Federal Student Aid). The College's deadline to complete the FAFSA is March 15, 2015 for new students and April 15, 2015 for continuing students. Students must file the FAFSA to qualify for need-based aid. Our FAFSA code is 002703.
Accept your Financial Aid Award
After you have submitted the FAFSA, you will receive a financial aid package from the College of Mount Saint Vincent. You must accept the award to receive federal and institutional grants, loans, and scholarships. If you have questions about your award, contact Financial Aid at (718) 405-3289.
Send in Your Enrollment Form
To secure your seat as a member of the Class of 2019, send in the enrollment decision form by May 1, 2015. A $300 enrollment deposit is required, plus an additional $200 residence hall security deposit for students choosing to live on campus. If you require an enrollment deposited extension, please contact the Office of Admission.
Fill Out Your Housing and Dining Application
If you plan to live on campus, once you have paid your enrollment deposit, fill out the online housing and dining application. The guaranteed housing deadline is June 15, 2015 (the application will be available in April).
Submit Proof of Immunization
The required immunization and the recommended physical exam forms are available online at www.mountsaintvincent.edu/healthforms. All forms must be submitted to the Health Center by August 1, 2015.
Send in Your Final High School Transcript
Please have your high school send your final transcript to the Office of Admission by August 1, 2015. To be considered official your transcript must include a full graduation date (MM/DD/YYYY), raised seal and official signature.
Important Deadlines
- FAFSA deadline: March 15, 2015 (new students) and April 15, 2015 (continuing students)
- Enrollment Deposit deadline: May 1, 2015
- Housing and Dining Application deadline: June 15, 2015
- Proof of Immunization deadline: August 1, 2015
- Final High School Transcript deadline: August 1, 2015
Important Phone Numbers
- Office of Admission: (718) 405-3267
Office of Academic Advisement and the Oxley Career Education Program:
(718) 405-3265
- Office of Campus Safety and Security: (718) 405-3722
- Office of Financial Aid: (718) 405-3289
- Office of Housing and Residence Life: (718) 405-3226
- Office of the Registrar: (718) 405-3771 or 3461 or 3254
- Office of Student Accounts: (718) 405-3297 or 3298
- No-Book Store: (718) 405-3462


text:
Hide Property Details
Description from the manager
- 6 bedrooms
- 6 bathrooms
- Sleeps 16
- House
Bedrooms: 6
Bathrooms: 6
Sleeps: 16
Type: House416 Pompano St - "Southern Charm"
Description from the manager
6BR / 5.5BA (K, 2Q, 4 Bunks, 2S) -Sleeps 16 - This home is the perfect choice for a great family vacation on Edisto Beach. Conveniently located mid-block on Pompano Street with an easy walk to the beach access. This spacious home has 6 bedrooms and 5.5 baths to comfortably accommodate a larger family. Entering from the covered front porch facing Pompano Street guests are welcomed in through a large foyer with a half bath. The streetside bedroom on right features 2 twin beds with a private bath(tub/shower). The streetside bedroom on the left has 2 sets of bunks and als a private bath(tub/shower). The beachside left bedroom features 1 queen bed...Read more
About the manager
About the manager
Edisto Sales and Rentals Realty LLC
Edisto Sales and Rentals Realty LLC
Response rate 0%
Response time N/A
Calendar updated today
Overall rating3.6 / 5.0 based on 164 reviews and 359 properties
416 Pompano St - "Southern Charm"
Edisto Beach, South Carolina
Additional Location Information
What Past Guests Are Saying
Have you stayed here?
This rental is awaiting reviews from past guests. Help out travelers and the owner by being the first to write a review!
Also Consider
FlipKey has rentals in over 11,000 destinations around the world:
Destin vacation rentals
1,265 rentals from $100/night
Myrtle Beach vacation rentals
1,074 rentals from $34/night
Panama City Beach condos
1,554 rentals from $90/night
Ocean City summer rentals
723 rentals from $100/night
Galveston vacation rentals
361 rentals from $125/night


text:
Wilko Johnson: 'We did our farewell tour. Now we're just doing tours'
- Culture
- March 22, 2014, 01:00
Wilko Johnson was diagnosed with terminal pancreatic cancer in January last year. Told he had less than a year to live, the renowned guitarist,(...)
Labour's Dr Feelgood cannot heal voter pain
- Politics
- March 22, 2013, 06:00
Like a robed champion boxer about to enter the ring, Eoin Holmes steps out of the car with massive earphones on and his(...)


text:
You never really know when you might need to screw in a really dark place. Having a tool equipped with a built-in LED light will make all the difference. This 6-in-1 multi-bit driver from Craftsman will help you get it in right the first time.
This is the official "Little Black Book" of the serious beer drinker. This 240-page Moleskine journal includes a beer glossary, pouring tips, glass types, a home brewing log, space for recipes, addresses, and tasting notes. Don't worry about space for phone numbers. If you're actually keeping a beer journal, chances are, dating is low priority.
Any campout that doesn't allow for nearby parking means you'll have to pack your gear into camp. In these scenarios, the lighter your pack the more enjoyable the jaunt. This ultralight and super-strong 2-person tent from MSR is purpose built for fast-and-light adventures. It features a Durashield coating to keep you dry, a simple 2-pole pitch, and a vented rainfly that provides airflow and exterior storage.
When the battery dies on your device, you start instinctively looking for outlets. And when there are no outlets you're screwed. But with the rechargeable Boost Turbine 2000, you're no longer screwed, you're actually cranking. When the Turbine is fully charged, it will recharge your phone but when it's not, you can use the handcrank to generate power without a plug.
Fleece is warm and cozy but once it's worn out it gets pretty gross. ReFleece is now taking tired old fleece garments and transforming them into cool cases and sleeves for your digital devices like iPads and Kindle readers. Using low energy manufacturing processes, they're giving fleece a new lease on life.
Producing pro-quality video shots like smooth follow cams and slow pans requires cumbersome, expensive equipment like dollys and slider tracks. The super portable design of the AirTracks inflatable slider now allows you to bag those high-tech shots with ease and you can carry the whole system along in your camera bag.
Even the biggest, bulkiest and stupidest looking iPad stands don't offer 6 different viewing and working positions, like this versatile case slash stand does. And instead of big, bulky, and stupid it's slim, sleek, and smart. Simply fold it into the desired configuration and start swiping.
This Tungsten coated, double-sided knife is a weapon designed by military experts, built specifically for stabbing and slashing. In a pinch the 4.7" Flat Grind blade will also work for whittling a marshmallow roasting stick or cutting open a stubborn bag of Fritos.
Made of real Cork wood, this unique iPad case from Portugal's Pomm brand is available until November 1 at a pre-order discount and also includes a Pomm tote bag that, as a man, you probably should not carry.
Are you indecisive? Tough question, we know. Either way, this versatile Vermont-made carryall gives you multiple options for how you carry it. You can go backpack style, shoulder strap mode, or full manpurse. It's made of repurposed military canvas and features solid brass hardware.


text:
appalachia posters, barn posters, cycle posters, fall posters, florida posters, fl posters, french posters, georgia posters, huffy posters, mountains posters
All prints ship in durable cardboard tubes.
Fine Art America is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality posters and prints. All of our posters are produced on state-of-the-art, professional-grade Epson printers.
We use acid-free paper with archival inks to guarantee that your posters last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Posters ship within 3 - 4 business days in durable cardboard tubes.
"Me and My Shadow" by Debra and Dave Vanderlaan ...Shadows cast from an old rusty bicycle adorn the old wooden planks at the antique shoppe...One never knows what one will find to photograph. This interesting jewel was found way in the back hidden behind a ton of junk, just waiting to be snapped for this fine art piece...
After 30 years in the floral and plant nursery business, Debra and Dave Vanderlaan sold both businesses and turned their life-long photography hobby into full-time obsession. The Vanderlaans are both award-winning photographers and well-known both domestically and internationally. Many of their images showcase the tropical landscapes of South Florida and the mountain vistas of the Smoky Mountains and many gorgeous scenes around the world. Their motto is Celebrate Life and that seemed a natural name for their gallery. Their images have been displayed in the Smithsonian Museum, North Carolina Museum of Art, Turchin Art Center in Boone NC, Palm Beach Photography Museum and many other museums and galleries around the country. Some of their...
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
If you've hesitated to purchase artwork online in the past, why not give us a try? You have nothing to lose!
We take great pride in the fact that 301,840 artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
Customer Service: 877-807-5901
(Call Any Time - 24 Hours Per Day)
All posters ship from our production facility within 24 hours of your order.


text:
Tweet Dr. John Hagan established Manomet's Forest Conservation Program, based in Brunswick, Maine, in 1997. He has led a variety of field studies on forestry and biodiversity in the region and has helped transform how the forestry sector thinks about protecting biodiversity. His early work on birds and forestry showed that clearcuts can be important habitat for many species of conservation concern. He has also shown that modern forest management threatens the persistence of many less charismatic species, such as lichens…Find out more »
Tweet Professor John A. Pickett is a world authority on semiochemicals in insect behavior and plant defense, and plays a leading role in the move away from the traditional use of wide-spectrum pesticides to more precise control through compounds targeted against specific pests at crucial stages in their life cycles. His work centers on the chemical ecology of interactions between insects, between insects and their plant or animal hosts, and between plants. John Pickett's contributions to the field of chemical ecology…Find out more »
Tweet This is a university-wide public event in collaboration with Community health and International Relations and with the support of the Office of the Provost. As a part of health week, "Future Food: Eco-friendly GMOs"will be presented by distinguished professor and Foreign Associate of the National Academy of Sciences, John A. Pickett from the prestigious Rothamsted Research Institution in the UK. Professor Pickett will present on the controversial topic of genetically modified crops as a tool to increase sustainability in our…Find out more »
Tweet The 9th Annual Future of Food and Nutrition Student Research Conference is a unique venue for graduate students across disciplines and from around the country to submit and present original research relating to the food system and nutrition science. Last year, over 200 graduate students came together to hear students from 30 universities present research from fields as diverse as anthropology and nutritional epidemiology. As a presenter or attendee, you will gain valuable professional experience presenting and discussing novel,…Find out more »
Tweet The 4th annual Fletcher School of Law and Diplomacy International Inquiry on the Warming Arctic comes at a time when the United States assumes the Chairmanship of the Arctic Council. This year The Fletcher School will convene high-level decision makers from diplomatic and security circles, cutting-edge energy and science researchers, and social, environmental and business stakeholders to investigate solutions to the Arctic Paradox and promote a sustainable future for Arctic inhabitants within a "High North, Low Tension" policy framework.Find out more »
Tweet Boston photographer David Arnold (www.doublexposure.net) precisely compares glacier and coral scenes to create "then and now" comparisons to illustrate the significant changes already taking place above and below the waterline of a warming planet. His Double Exposure exhibit opened at Boston's Museum of Science in 2008, then toured the country non-stop for four years. Currently he is working on a second exhibit. He will speak personally to the power of photography, and reflect with audience help about how we got into…Find out more »
Tweet New England fisheries date back several centuries, with the iconic Atlantic cod playing a key role in our countries' development. In the 1970′s, faced with declining fish stocks, Congress passed the Magnuson-Stevens Act to create sustainable fisheries that benefit our fishermen and our Nation. The Act created eight Fishery Management Councils made up of fishermen, along with state and federal managers to develop measures to manage fisheries within the legal requirements. The New England Council is responsible for developing…Find out more »
© 2015 Sustainability at Tufts
Theme by Anders Noren — Up ↑


text:
Sleep Inn & Suites Austin - Northeast
8410 Highway 290 East
Austin, TX 78724
Phone: (512) 524-5400
Fax: (512) 524-5401
Austin Zoo
10808 Rawhide Trail
Austin, TX 78736
+1 512 288 1490
Summer - Feb to Oct - 09:30 AM to 06:00 PM,Winter - Nov to Jan - 09:30 AM to 05:30 PMEnjoy a day at this educational, family friendly wildlife preserve. Austin Zoo, which is located on land that originally housed a goat ranch, started out with only a small selection of animals and has since grown into a full-fledged wild animal sanctuary and zoo. See Bengal tigers, lemurs, a butterfly garden and more! The picnic areas are perfect for a birthday party or company event.
Earn valuable points toward free nights.


text:
Smart Links 28 February 2012
Commentary on investing, investing in energy, evacuating Tokyo, how the Euro will be dismembered, teacher's salaries, and how to apologize.
The 10 investment lesssons.
Market Watch -- 10 investment lessons from Jeremy Grantham
The chief investment strategist of Boston-based institutional money manager GMO LLC doesn't mince words.
The sky scraper index. (ed's note – it's not looking good in China).
PIMCO likes energy.
PIMCO – Game Changer
America is fortunate to have abundant energy resources. Combined with technological advancements and increasing capital investment, these vast resources are helping to create employment, expand private sector business investment and grow secure onshore U.S. energy supplies.
How many companies have been the largest (in terms of market capitalisation).
New York Times -- Confronting a Law Of Limits
These days, it's hard to find a superlative that adequately describes Apple.
The plan to evacuate Tokyo. Thanks to Jeremy of Tokyo.
New York Times -- Japan Weighed Evacuating Tokyo in Nuclear Crisis
In the darkest moments of last year's nuclear accident, Japanese leaders did not know the actual extent of damage at the plant and secretly considered the possibility of evacuating Tokyo, even as they tried to play down the risks in public, an independent investigation into the accident disclosed on Monday.
The Euro end game.
Teachers aren't happy. (ed's note – is a national comparison of teacher's salaries relevant?).
Globe and Mail -- Crosscheck: How B.C. teachers rank in Canada
Teachers across British Columbia are voting on Tuesday and Wednesday on whether to walk off the job just as the provincial government is expected to impose a contract.
Toronto Star -- Dirty tricks: Liberal leader Bob Rae shows how to take responsibility
Bob Rae, the interim Liberal leader, showed on Monday how a political leader needs to respond when it becomes clear there's been wrong-doing in his ranks.
|Add your opinion
|Rate this story
|9 votes
User login
Login using social networks
Twin Virtues: Inequality of Outcomes & Equality of Opportunity©
LimeSpot's personalization technology shows online shoppers products they are most likely to buy and provides retailers with increased traffic and demographics.
Your online store has a mind of its own. Make it intelligent.
LimeSpot: Intelligent Personalization™
Simple, easy, and inexpensive: LimeSpot's Intelligent Personalization™
Helping make small retailers great.
LimeSpot: Own Your Experience
Leveraging Social Networks for Profit
Our Intelligent Personalization™ engine relates your products' titles and descriptions with your shoppers' buying/browsing behaviour and social profiles.
The personalized option is a third sales channel offering your shoppers a better online experience than the standard 'click and search' because it mimics the real world shopping experience while showing them what they are most likely to be interested in.
Twin Virtues
Ultimately, the most successful societies find the balance between the twin virtues of inequality of outcomes and equality of opportunity.
The new politics must marry the twin virtues of unequal outcomes and equality of opportunity.
When too few get too much everybody loses.
Feminism is about women living their lives on their own terms, marshaling the resources of the society to make that possible, and men embracing this as vital to a successful society and their own liberation.
Can it be that striving for equality of opportunity however imperfect the process not only benefits the individual but also creates benefits for the society that are unintended but wonderful?
Economics must be a 'moral enterprise' as much as politics claims to be. Economic outcomes need to be framed in terms of right and wrong not just efficiency if only because these often align in surprising ways that are good for society and the economy.
My vision of Canada is that any Canadian child from a family of limited circumstance can expect to have a chance at lifetime of unlimited opportunities.
Tax policy should be founded on the principle of generating steady tax revenues sufficient to maximise environmentally sustainable economic growth in order to fund fair government.
Public policy should be designed to decrease inequality before the law and increase equality of opportunity.
Capitalism is not the problem; the problem is what we do with capitalism.
Content is always more difficult to argue than conspiracy.
Let the state regulate and the market operate (most things).
Welfare strategies are best designed as a hand up, not as a hand out.
Political debate should not be fact free fighting.
Explanation lasts longer than eloquence.
Always favour empowerment over dependency.
The most enduring public figures are embraced for the causes they fought for and not the concept of themselves they hoped others would remember them by.
Find your voice and don't be the echo of somebody else.
It is possible to operate on two different levels: the practical, cautious and conservative; and the realm of ideas, open, free, and radical.


text:
- Shopping Bag ( 0 items )
Customer Reviews for
Something Blue
Page 1 of 1
Posted February 10, 2013
Good light hearted reading
This one could be made into a fine comedy with the right casting of characters Good reading One I will come back toWas this review helpful? Yes NoThank you for your feedback. Report this reviewThank you, this review has been flagged.
Posted February 25, 2013
No text was provided for this review.
Page 1 of 1


text:
Mar 19, 2014
Men's Basketball
Crimson Classic: 1988 OU vs. UTC (PREMIUM)
Oklahoma's road to the 1988 Final Four began with a victory over Tennessee-Chattanooga at the Omni Colliseum in Atlanta. Relive OU's win with this Crimson Classic.
Coach Reynolds Wired for Sound
Fun-Filled Day for Female Fans
This is Only the Beginning
Interview with The Champ
Coach Cooks Wired for Sound
Secondary Building on...
Sooners Get Back to Football
From No. 13 to No. 1
OU Earns No. 1 Overall Seed
A Star from the North
2015 OU Softball Intro Video
Racism: We Won't Stand For It
Not on OUr Campus
Parker Off to a Perfect Start
2015 OU Pro Day Recap
Lincoln Riley One-on-One
New Energy at First Spring...
A Bond Beyond
D.J. Bennett: This Is What I...
A Long Time Coming
- Most Recent
- General
- Baseball
- Men's Basketball
- Women's Basketball
- Cross Country
- Football
- Men's Golf
- Women's Golf
- Men's Gymnastics
- Women's Gymnastics
- Rowing
- Soccer
- Softball
- Men's Tennis
- Women's Tennis
- Track and Field
- Volleyball
- Wrestling


text:
PlayStation 3
This is a split board - You can return to the Split List for other boards.
So, what's going to happen to Silent Hill saga?
- Back To:
- Board List
- Topic List
- Topic Archived
- Page 1 of 2
- Last
1.-SH Downpour did poorly on sales, and critics were really terrible. IMO was a very good decent game.
2.-SH HD Collection was terrible, it shouldn't have been released like that.
3.-SH Revelation. Although I really liked the movie, it didn't do it very well at theaters which again is bad.
Definitely it wasn't a good year for SH.
Albert1285 posted...
1.-SH Downpour did poorly on sales, and critics were really terrible. IMO was a very good decent game.
Yo forgot Book of memories. It was actually not that bad.
But yeah, people said that 2012 was gonna be a good year for horror fans, but it was pretty bad lol.
Horror games are boring and depressing.
Eminem Is The Greatest Musician Of All Time
Shawn Michaels Is The Greatest Athlete Of All Time
warrenmats posted...
Albert1285 posted...1.-SH Downpour did poorly on sales, and critics were really terrible. IMO was a very good decent game.
Oh yeah , I guess I forgot it because it's terrible crap that shouldn't be considered part of Silent Hill. lol
Downpour is effing fantastic and i found it to be very fun. The again, I loved Homecoming as well and felt 4 was a little mediocre, so I don't know what that says about me.
The HD collection is fine, they could have done a lot better, but they didn't. I still had fun with it and it brought back tons of memories and scary good times.
Revelations was garbage. Pure. Effing. Garbage. It did everything wrong that the first movie got right. I mean, all the nods to the games (including the Origins and Downpour nods), were great, but c'mon, Pyramid Head duking it out with another boss? That was cheesy and stupid.
Book of Memories is fun as hell, even though it isn't your typical Silent Hill game, more people should play it because it is pretty fun.
I'm pretty sure more Silent Hill games/movies/books etc.will come out.
They need to really go back and look at what made SilentHill 1 and 2 so fantastic, and bring that to modern gaming, and I feel Downpour did a pretty good job of this, like using the rain to take the place of fog. If they used more of the classic stuff in modern gaming, they could make a badass Silent Hill game.
I loved downpour And homecoming
necro00 posted...
I loved downpour And homecoming
-> este914 <-
necro00 posted...
I loved downpour And homecoming
critics and fans didn't tough because the reception and sales were pitiful.
CyborgTwenty posted...
necro00 posted...I loved downpour And homecoming
I'm a fan and I loved Downpour and Homecoming.
Just because some critics and fans complained that Downpour and Homecoming weren't Silent Hill 2, doesn't mean they are bad or poor games.
Sales don't really mean a thing this early into both Homecoming and Downpour's life cycle, because even the great Silent Hill 2 has sold barely over a million copies in the 12 years its been out.
Check back in 10 years and see how many copies have been sold and then we will have a good idea.
I hate when new Silent Hill games come out because it's ALWAYS "this game isn't like Silent Hill 2 therefore it sucks".
People need to give that crap a rest.
1. Some Western studio destroys the series some more.
2. Kojima takes over and develops a mindblowing SH on FOX Engine.


text:
Backyard Advice Very Welcome
We are finally ready to re-do the back yard
Basic info
We live in Fairfax County, Zip 22033. This is Zone 7a
Main purposes:
1. A place to entertain some, grilling out, 6 adults, 3-5 kids.
2. A place for our boy to play some (he's 4 years old as of October 2013).
We have re-done a dilapidated part of the fence already, and we have felled some trees that were sadly mis-treated by the former owners, and had the stumps ground.
We have found a very good local hardscaping company, and they have provided a rough sketch (see link below and they have a lot of Facebook pictures of their work (link in the follow-up )
Our questions
What do you think generally, all advice welcome.
1. Is the dining terrace to the North (right hand side) big enough to cope with the e.g. Portico dining set?
2. Is it worth considering a pergola around/over the dining area? I'm thinking shade and interest, and screening of the neighbors yard.
3. Where should the grill go? I'm thinking the far side, between the canopy of a crape myrtle and a neighbors large pine. Plus it makes sense to me to have the natural gas line and some electricity spur off to where the grill will be.
4. The smaller "quiet seating area" is quite shady. I'm thinking more cut paving, or possibly random flagstones. The problem I have with the random flags is the filler: I think it's too shady for grass. Maybe small pebbles would work?
OK over to you. I'm good with tools, and we have some. What do you think?
Here is a link that might be useful: sketch
This post was edited by BritCvS on Mon, Oct 14, 13 at 22:09
Here is the facebook link to the hardscaping company's photos
Here is a link that might be useful: Classic_Hardscaping
There is a flickr.com set of (too many) photos of the back yard and the link below. Tomorrow I'll edit to get just the pertinent pictures posted.
Here is a link that might be useful: flickr set
In order to tell if the dining patio is large enough for the d. set, you would need to show plan scale and compare with d. set measurements.
Having a pergola would depend on your level of interest compared to cost. IMO, the oval/round patio shape does not scream for a rectangular/square (as most are) pergola. Other shade and screening might be better/less expensive.
"...I'm thinking the far side, between the canopy of a crape myrtle and a neighbors large pine." From this description, I don't know where this place is. (The smaller notes on the plan are not readable; the plant material is unknown.)
if you surround flagstone with pebbles, I think you will lose the nice effect. I would explore if there is a groundcover that would work with the low light conditions.
general notes about plan ...
Excellent advice and thank you Yardvaark.
I hadn't thought about the pergola shape. Good advice! I suppose we can use the umbrella that can accompany the table.
The general notes I agree with completely. I was worried about that looping pinch. Consider that advice taken. I also agreed with the awkward space for planting, and the flow comment.
I don't have a scale plan yet. But I do have the yard dimensions from our plat, where I can see that the total North-South space available is around 30 feet from the near south side of the patio (by your green p) to the far North fence (where your yellow much word is) . I do have the table dimensions:
Table dimensions: 86" L x 42" D x 29" H
Chair dimensions: 25.5" L x 22" D x 33" H
The table image is uploaded.
I'll google room for table dimensions and see what comes up as a general rule of thumb.
I'm also wondering where to put the grill. The kitchen is in the middle rear of the house.
The plat is linked to below
Here is a link that might be useful: Plat
"I'm also wondering where to put the grill. The kitchen is in the middle rear of the house." Since grills are generally most conveniently located somewhere between the door to the kitchen access and the outdoor dining area, it's likely that the grill would go in the vicinity of where I show the chartreuse-colored double-headed arrow, where there is some blank wall space and depending on what the window situation is. This is a good reason why to especially have no pinching in that area.


text:
DMK leader M. Karunanidhi on Thursday condemned the arrest of 75 fishermen and seizure of their boats by the Sri Lankan Navy. The arrests proved that the Sri Lankan government had no genuine interest in resolving issues concerning fishermen on both sides.
"If the Sri Lankan government is really interested in resolving the problems of fishermen it should not have indulged in arrests. We have reasons to doubt the intentions of the Sri Lankan government," he said in a statement.
The DMK leader said 25 fishermen from Rameswaram were arrested and their boats seized. Another 50 fishermen from Pudukottai and Karaikal along with their boats were arrested by the Sri Lankan Navy.
People's hope dashed
While the ruling AIADMK was claiming that all the Tamil fishermen lodged in jails in Sri Lanka had been released due to the efforts of Chief Minister Jayalalithaa, the fresh arrests before the second round of talks between fishermen from India and Sri Lanka on March 25 had dashed people's hope, Mr. Karunanidhi said.


text:
Here is shown how to send secret Skype smiles. I have to agree that such little funny things make a simple piece of software stand out from the rest.
... Skype Ну и остальные скрытые смайлы: secret Skype smiles shown when you send this secret Skype codes .
Stay in touch with your family and friends for free on Skype. Download Skype today to chat and call on desktop and mobile.
Video chat for free on mobile or desktop with Skype. Skype connects family and friends with international video calls.
Skype Emoticons and Smileys, like all other Emoticons and Smileys, have evolved : over recent years. Initially they were simple graphics and about the same size as
Não se esqueça de dar uma passada na fanpage no Google+ https://plus.google.com/b/10669816931... ----- Instale o plugin do canal, no seu navegador, para ...
Version history. 1.2.6: Added Malthe, Tauri, and Priidu from Skype 5. Removed Amazon banner ad and added the +1 button. 2011-09-05. 1.2.5: New Amazon Affiliate banner.
Скрытые смайлы в Skype. Это уже давным-давно бродит по Сети, но, может быть, есть те, кто еще не ...
List of emoticons for Skype with text codes for hidden smileys 3. Skype ... [Выделить] kakie estj "sekretnie" smaili krome (mooning) (finger) (bandit)? 9.
Mohammad Smaili is on Facebook. Join Facebook to connect with Mohammad Smaili and others you may know. Facebook gives people the power to share and makes...


text:
We're sorry, we need more information to run your search. Please enter a last name (adding more details will improve your results).
Uncovering the exact Leah Duncan you are looking for is simple if you turn to PeopleFinders.com for help. We provide an amazing array of details for your people search like age, recent addresses, and phone numbers. For example, Leah Duncan was born in [YOB] and is 103 years old. The latest address for Leah Duncan is located in Longboat Key, FL.
You can narrow down your search for the right Leah Duncan by employing any data that we have on hand. Uncover the exact Leah using info such as previous residences and known aliases. Browse through extra details about the person such as background checks, criminal profiles, and email addresses on PeopleFinders.com. If this Leah is not the person you are searching for, examine the list of people with the Duncan in Longboat Key, FL given above. This list could incorporate name, age, location, and relatives.
Enter more info into the search fields above in order to refine your results. A first name, middle name, last name, city, state and/or age can be the lost piece to finding Leah Duncan. When you uncover the Leah Duncan you need, you can then peruse all the public records data we have on Leah Duncan using our exclusive and trusted DataTsunami™ logic that enables an easy data collection process.


text:
Article Writing and Manual Spinning
Closed - This job posting has been filled and work has been completed.
Job Description
We are looking for an article writer to write about 50-100 articles per month and MANUALLY spin some of them.
Articles will be 500 - 1000 words and on various topics.
Please quote on:
1. per article price
2. price to manually spin a single article
Other open jobs by this client
- Hourly – Experience JAVA Developer Wanted


text:
I usually come directly to the forum. Sometimes I spend months without going to the homepage.
Just watched it, not interested.
Just watched it, not interested.
You make the editors weep. :P
The art looks a bit more cutesy than I would like, but i'm a big Atelier fan so it might be worth a shot.


text:
Are you Hsin-Yi Chen?Claim your profile
Publications (66)141.35 Total impact
Article: Insight into two antioxidants binding to the catalase NADPH binding site from traditional Chinese medicines[Show abstract] [Hide abstract]
ABSTRACT: Catalase is an important enzyme performs decomposition of two molecular of hydrogen peroxide to water molecules and oxygen in aerobic organism. Deficiency or inactive catalase are implicated cell damage and lead to inflammation, aging and cancer. In order to develop novel nature product that prevent inactive catalase generation, the world largest traditional Chinese medicine (TCM) database (http://tcm.cmu.edu.tw/) were employed to this study, which combined with high-throughput virtual screening and molecular dynamics (MD) simulation to investigate potent nature compounds for keeping catalase active. We found the two nature product, Hesperidin and 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG), the found ligands perform high binding affinity with catalase. The results of MD simulation show that THSG is the most stable in trajectory analysis over all simulation times. Besides, THSG can affect the catalase structure more compact during the process of MD simulation. In addition, the radical scavenging assay showing that THSG has more potential antioxidant activity than Hesperidin. Therefore, we regard the nature TCM compound, THSG, could be used to develop potential drugs that might have similar effect to keep catalase active and prevent the inactive form generation by hydrogen peroxide.RSC Advances 12/2014; 5(9). DOI:10.1039/C4RA14734K · 3.71 Impact Factor
Article: Association Between Zolpidem Use and Glaucoma Risk: A Taiwanese Population-Based Case-Control Study[Show abstract] [Hide abstract]
ABSTRACT: To date, the relationship between zolpidem use and subsequent risk of glaucoma in a Taiwanese population has not been assessed. We used data from the National Health Insurance system to investigate whether zolpidem use was related to glaucoma risk. A 1:4 matched case-control study was conducted. The cases were patients newly diagnosed with glaucoma from 2001 to 2010. The controls were randomly selected non-glaucoma subjects matched by sex and age (±5 years). Zolpidem exposure and/or the average dosage of zolpidem used (mg/year) were evaluated. Medical comorbidities were considered as confounding factors. Multiple logistic regression models were used to evaluate the potential risk of zolpidem exposure on glaucoma with/without adjustment for the effects of confounding variables. The exposure rate of zolpidem use in the glaucoma group was significantly higher than that of the control group (2.8% vs. 2.0%, P < 0.0001). The adjusted odds ratio (OR) of the risk of glaucoma for those with zolpidem use vs. those without was 1.19 (95% confidence interval [CI], 1.02-1.38). Compared to non-zolpidem users, zolpidem users with an average dose of more than 200 mg/year had significantly increased risk of glaucoma (OR 1.31, 95% CI 1.03-1.68). This study suggests that the use of zolpidem might increase the risk of subsequent glaucoma. Further confirmatory studies are recommended to clarify this important issue.Journal of Epidemiology 08/2014; 25(1). DOI:10.2188/jea.JE20140051 · 2.86 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Objective. To investigate if different treatment strategy of obstructive sleep apnea (OSA) was associated glaucoma risk in Taiwanese population. Methods. Population-based retrospective cohort study was conducted using data sourced from the Longitudinal Health Insurance Database 2000. We included 2528 OSA patients and randomly selected and matched 10112 subjects without OSA as the control cohort. The risk of glaucoma in OSA patients was investigated based on the managements of OSA (without treatment, with surgery, with continuous positive airway pressure (CPAP) treatment, and with multiple modalities). The multivariable Cox regression was used to estimate hazard ratio (HR) after adjusting for sex, age, hypertension, diabetes, hyperlipidemia, and coronary artery disease. Results. The adjusted HR of glaucoma for OSA patients was 1.88 (95% CI: 1.46-2.42), compared with controls. For patients without treatment, the adjusted HR was 2.15 (95% CI: 1.60-2.88). For patients with treatments, the adjusted HRs of glaucoma were not significantly different from controls, except for those with CPAP (adjusted HR = 1.65, 95% CI = 1.09-2.49). Conclusions. OSA is associated with an increased risk of glaucoma. However, surgery reduces slightly the glaucoma hazard for OSA patients.Journal of Ophthalmology 07/2014; 2014:838912. DOI:10.1155/2014/838912 · 1.94 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the diagnostic accuracy of glaucoma in different stages, different types of glaucoma, and different ethnic groups using Stratus optical coherence tomography (OCT).Optometry and vision science: official publication of the American Academy of Optometry 07/2014; DOI:10.1097/OPX.0000000000000331 · 1.53 Impact Factor
Article: In Silico Investigation of Potential mTOR Inhibitors from Traditional Chinese Medicine for Treatment of Leigh Syndrome[Show abstract] [Hide abstract]
ABSTRACT: A recent research demonstrates that the inhibition of mammalian target of rapamycin (mTOR) improves survival and health for patients with Leigh syndrome. mTOR proteins can be treated as drug target proteins against Leigh syndrome and other mitochondrial disorders. In this study, we aim to identify potent TCM compounds from the TCM Database@Taiwan as lead compounds of mTOR inhibitors. PONDR-Fit protocol was employed to predict the disordered disposition in mTOR protein before virtual screening. After virtual screening, the MD simulation was employed to validate the stability of interactions between each ligand and mTOR protein in the docking poses from docking simulation. The top TCM compounds, picrasidine M and acerosin, have higher binding affinities with target protein in docking simulation than control. There have H-bonds with residues Val2240 and π interactions with common residue Trp2239. After MD simulation, the top TCM compounds maintain similar docking poses under dynamic conditions. The top two TCM compounds, picrasidine M and acerosin, were extracted from Picrasma quassioides (D. Don) Benn. and Vitex negundo L. Hence, we propose the TCM compounds, picrasidine M and acerosin, as potential candidates as lead compounds for further study in drug development process with the mTOR protein against Leigh syndrome and other mitochondrial disorders.BioMed Research International 06/2014; 2014:139492. DOI:10.1155/2014/139492 · 2.71 Impact Factor
Article: Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor[Show abstract] [Hide abstract]
ABSTRACT: Recently, cardiovascular disease, also known as loop circulatory system diseases or disorders, is one of the serious diseases including heart disease, stroke, atherosclerosis, myocardial infarction, hypertension, hypotension, and thrombosis. Human pregnane X receptor, PXR, plays a crucial role in exogenous and endobiotic metabolism for rabbit, rat, mouse, and human. The PXR activation can protect the blood vessels from damage of hazardous substances. In this study we aim to investigate the potent lead compounds as PXR receptor agonist against cardiovascular disease. To improve drug development of TCM compounds, we aim to investigate the potent lead compounds as PXR agonists from the TCM compounds in TCM Database@Taiwan. The top three TCM compounds, bis(4-hydroxybenzyl) ether mono-β-D-glucopyranoside (BEMG), ixerisoside, and tangshenoside II, have displayed higher potent binding affinities than the positive control, PNU-142721, in the docking simulation. After MD simulations, which can optimize the result of docking simulation and validate the stability of H-bonds between each ligand and PXR protein under dynamic conditions, top TCM compounds, BEMG and tangshenoside II, maintain most of interactions with PXR protein, which keep the ligand binding stable in the binding domain. Hence, we propose BEMG and tangshenoside II as potential lead compounds for further study in drug development process with the PXR protein.BioMed Research International 06/2014; 2014:950191. DOI:10.1155/2014/950191 · 2.71 Impact Factor
Article: Potential Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Inhibitor from Traditional Chinese Medicine against Cancers[Show abstract] [Hide abstract]
ABSTRACT: A recent research of cancer has indicated that the mutant of isocitrate dehydrogenase 1 and 2 (IDH1 and 2) genes will induce various cancers, including chondrosarcoma, cholangiocarcinomas, and acute myelogenous leukemia due to the effect of point mutations in the active-site arginine residues of isocitrate dehydrogenase (IDH), such as IDH1/R132, IDH2/R140, and IDH2/R172. As the inhibition for those tumor-associated mutant IDH proteins may induce differentiation of those cancer cells, these tumor-associated mutant IDH proteins can be treated as a drug target proteins for a differentiation therapy against cancers. In this study, we aim to identify the potent TCM compounds from the TCM Database@Taiwan as lead compounds of IDH2 R140Q mutant inhibitor. Comparing to the IDH2 R140Q mutant protein inhibitor, AGI-6780, the top two TCM compounds, precatorine and abrine, have higher binding affinities with target protein in docking simulation. After MD simulation, the top two TCM compounds remain as the same docking poses under dynamic conditions. In addition, precatorine is extracted from Abrus precatorius L., which represents the cytotoxic and proapoptotic effects for breast cancer and several tumor lines. Hence, we propose the TCM compounds, precatorine and abrine, as potential candidates as lead compounds for further study in drug development process with the IDH2 R140Q mutant protein against cancer.BioMed Research International 06/2014; 2014:364625. DOI:10.1155/2014/364625 · 2.71 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disease that will affect quality of life and, working efficiency, and produce negative thoughts for patients. Current therapy of RA is treated with disease-modifying antirheumatic drugs (DMARDs). Although most of these treatment methods are effective, most patients still have a pleasant experience either due to poor efficacy or side effects or both. Interleukin-6 receptor (IL6R) is important in the pathogenesis of RA. In this study, we would like to detect the potential candidates which inhibit IL6R against RA from traditional Chinese medicine (TCM). We use TCM compounds from the TCM Database@Taiwan for virtually screening the potential IL6R inhibitors. The TCM candidate compound, calycosin, has potent binding affinity with IL6R protein. The molecular dynamics simulation was employed to validate the stability of interaction in the protein complex with calycosin. The analysis indicates that protein complex with calycosin is more stable. In addition, calycosin is known to be one of the components of Angelica sinensis, which has been indicated to have an important role in the treatment of rheumatoid arthritis. Therefore, calycosin is a potential candidate as lead compounds for further study in drug development process with IL6R protein against rheumatoid arthritis.BioMed Research International 06/2014; 2014:528018. DOI:10.1155/2014/528018 · 2.71 Impact Factor
Article: Finding Inhibitors of Mutant Superoxide Dismutase-1 for Amyotrophic Lateral Sclerosis Therapy from Traditional Chinese Medicine[Show abstract] [Hide abstract]
ABSTRACT: Superoxide dismutase type 1 (SOD1) mutations cause protein aggregation and decrease protein stability, which are linked to amyotrophic lateral sclerosis (ALS) disease. This research utilizes the world's largest traditional Chinese medicine (TCM) database to search novel inhibitors of mutant SOD1, and molecular dynamics (MD) simulations were used to analyze the stability of protein that interacted with docked ligands. Docking results show that hesperidin and 2,3,5,4'-tetrahydroxystilbene-2-O- β -D-glucoside (THSG) have high affinity to mutant SOD1 and then dopamine. For MD simulation analysis, hesperidin and THSG displayed similar value of RMSD with dopamine, and the migration analysis reveals stable fluctuation at the end of MD simulation time. Interestingly, distance between the protein and ligand has distinct difference, and hesperidin changes the position from initial binding site to the other place. In flexibility of residues analysis, the secondary structure among all complexes does not change, indicating that the structure are not affect ligand binding. The binding poses of hesperidin and THSG are similar to dopamine after molecular simulation. Our result indicated that hesperidin and THSG might be potential lead compound to design inhibitors of mutant SOD1 for ALS therapy.Evidence-based Complementary and Alternative Medicine 05/2014; 2014:156276. DOI:10.1155/2014/156276 · 2.18 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Protein phosphatase 2A (PP2A) is an important phosphatase which regulates various cellular processes, such as protein synthesis, cell growth, cellular signaling, apoptosis, metabolism, and stress responses. It is a holoenzyme composed of the structural A and catalytic C subunits and a regulatory B subunit. As an environmental toxin, okadaic acid, is a tumor promoter and binds to PP2A catalytic C subunit and the cancer-associated mutations in PP2A structural A subunit in human tumor tissue; PP2A may have tumor-suppressing function. It is a potential drug target in the treatment of cancer. In this study, we screen the TCM compounds in TCM Database@Taiwan to investigate the potent lead compounds as PP2A agent. The results of docking simulation are optimized under dynamic conditions by MD simulations after virtual screening to validate the stability of H-bonds between PP2A- α protein and each ligand. The top TCM candidates, trichosanatine and squamosamide, have potential binding affinities and interactions with key residues Arg89 and Arg214 in the docking simulation. In addition, these interactions were stable under dynamic conditions. Hence, we propose the TCM compounds, trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein.Evidence-based Complementary and Alternative Medicine 04/2014; 2014:436863. DOI:10.1155/2014/436863 · 2.18 Impact Factor
Article: Computational design of apolipoprotein e4 inhibitors for Alzheimer's disease therapy from traditional chinese medicine.[Show abstract] [Hide abstract]
ABSTRACT: Apolipoprotein E4 (Apo E4) is the major genetic risk factor in the causation of Alzheimer's disease (AD). In this study we utilize virtual screening of the world's largest traditional Chinese medicine (TCM) database and investigate potential compounds for the inhibition of ApoE4. We present the top three TCM candidates: Solapalmitine, Isodesacetyluvaricin, and Budmunchiamine L5 for further investigation. Dynamics analysis and molecular dynamics (MD) simulation were used to simulate protein-ligand complexes for observing the interactions and protein variations. Budmunchiamine L5 did not have the highest score from virtual screening; however, the dynamics pose is similar to the initial docking pose after MD simulation. Trajectory analysis reveals that Budmunchiamine L5 was stable over all simulation times. The migration distance of Budmunchiamine L5 illustrates that docked ligands are not variable from the initial docked site. Interestingly, Arg158 was observed to form H-bonds with Budmunchiamine L5 in the docking pose and MD snapshot, which indicates that the TCM compounds could stably bind to ApoE4. Our results show that Budmunchiamine L5 has good absorption, blood brain barrier (BBB) penetration, and less toxicity according to absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction and could, therefore, be safely used for developing novel ApoE4 inhibitors.BioMed Research International 01/2014; 2014:452625. DOI:10.1155/2014/452625 · 2.71 Impact Factor
Article: Potential Smoothened Inhibitor from Traditional Chinese Medicine against the Disease of Diabetes, Obesity, and Cancer.[Show abstract] [Hide abstract]
ABSTRACT: Nowadays, obesity becomes a serious global problem, which can induce a series of diseases such as type 2 diabetes mellitus, cancer, cardiovascular disease, metabolic syndrome, and stoke. For the mechanisms of diseases, the hedgehog signaling pathway plays an important role in body patterning during embryogenesis. For this reason, smoothened homologue (Smo) protein had been indicated as the drug target. In addition, the small-molecule Smo inhibitor had also been used in oncology clinical trials. To improve drug development of TCM compounds, we aim to investigate the potent lead compounds as Smo inhibitor from the TCM compounds in TCM Database@Taiwan. The top three TCM compounds, precatorine, labiatic acid, and 2,2'-[benzene-1,4-diylbis(methanediyloxybenzene-4,1-diyl)]bis(oxoacetic acid), have displayed higher potent binding affinities than the positive control, LY2940680, in the docking simulation. After MD simulations, which can optimize the result of docking simulation and validate the stability of H-bonds between each ligand and Smo protein under dynamic conditions, top three TCM compounds maintain most of interactions with Smo protein, which keep the ligand binding stable in the binding domain. Hence, we propose precatorine, labiatic acid, and 2,2'-[benzene-1,4-diylbis(methanediyloxybenzene-4,1-diyl)]bis(oxoacetic acid) as potential lead compounds for further study in drug development process with the Smo protein.BioMed Research International 01/2014; 2014:873010. DOI:10.1155/2014/873010 · 2.71 Impact Factor
Article: In Silico Investigation of Potential Pyruvate Kinase M2 Regulators from Traditional Chinese Medicine against Cancers.[Show abstract] [Hide abstract]
ABSTRACT: A recent research in cancer research demonstrates that tumor-specific pyruvate kinase M2 (PKM2) plays an important role in chromosome segregation and mitosis progression of tumor cells. To improve the drug development of TCM compounds, we aim to identify potent TCM compounds as lead compounds of PKM2 regulators. PONDR-Fit protocol was utilized to predict the disordered disposition in the binding domain of PKM2 protein before virtual screening as the disordered structure in the protein may cause the side effect and downregulation of the possibility of ligand to bind with target protein. MD simulation was performed to validate the stability of interactions between PKM2 proteins and each ligand after virtual screening. The top TCM compounds, saussureamine C and precatorine, extracted from Lycium chinense Mill. and Abrus precatorius L., respectively, have higher binding affinities with target protein in docking simulation than control. They have stable H-bonds with residues A:Lys311 and some other residues in both chains of PKM2 protein. Hence, we propose the TCM compounds, saussureamine C and precatorine, as potential candidates as lead compounds for further study in drug development process with the PKM2 protein against cancer.BioMed Research International 01/2014; 2014:189495. DOI:10.1155/2014/189495 · 2.71 Impact Factor
Article: In Silico Investigation of Potential TRAF6 Inhibitor from Traditional Chinese Medicine against Cancers.[Show abstract] [Hide abstract]
ABSTRACT: It has been indicated that tumor necrosis factor receptor-associated factor-6 (TRAF6) will upregulate the expression of hypoxia-inducible factor-1α (HIF-1α) and promote tumor angiogenesis. TRAF6 proteins can be treated as drug target proteins for a differentiation therapy against cancers. As structural disordered disposition in the protein may induce the side-effect and reduce the occupancy for ligand to bind with target protein, PONDR-Fit protocol was performed to predict the disordered disposition in TRAF6 protein before virtual screening. TCM compounds from the TCM Database@Taiwan were employed for virtual screening to identify potent compounds as lead compounds of TRAF6 inhibitor. After virtual screening, the MD simulation was performed to validate the stability of interactions between TRAF6 proteins and each ligand. The top TCM compounds, tryptophan, diiodotyrosine, and saussureamine C, extracted from Saussurea lappa Clarke, Bos taurus domesticus Gmelin, and Lycium chinense Mill., have higher binding affinities with target protein in docking simulation. However, the docking pose of TRAF6 protein with tryptophan is not stable under dynamic condition. For the other two TCM candidates, diiodotyrosine and saussureamine C maintain the similar docking poses under dynamic conditions. Hence, we propose the TCM compounds, diiodotyrosine and saussureamine C, as potential candidates as lead compounds for further study in drug development process with the TRAF6 protein against cancer.BioMed Research International 01/2014; 2014:429486. DOI:10.1155/2014/429486 · 2.71 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Insomnia is a prominent modern disease that affects an increasing population. Undesirable side effects of commercial drugs highlight the need to develop novel insomnia drugs. Virtual screening of traditional chinese medicine Database@Taiwan (TCM Database@Taiwan) identified 2-O-Caffeoyl tartaric acid (1), 2-O-Feruloyl tartaric acid (2), and Mumefural (3) as potential agonists for both gamma-amino butyric acid (GABA) or benzodiazepine (BZ) binding sites. The TCM candidates exhibited higher affinity than GABA and Zolpidem, a phenomenon that could be attributed to higher quantity of stabilizing H-bonds. Efficacy profiles using support vector machines and pharmacophore contour also suggest drug potential of the TCM candidates. Fragments added to the de novo derivatives 3a, 3b, 3c for GABA binding site, and 1a, 2a, and 3d for BZ binding site contributed to new binding sites and structural stability, further optimizing binding to GABA or BZ binding sites. Increased opening of the ion channel by candidate ligands provide strong support for their potential biological functions. The dual binding properties of the TCM candidates present a unique opportunity to develop twin-targeting drugs with less side effects. Derivative structures can be used as starting points for developing high affinity GABAA receptor agonists with specificity towards GABA binding site and BZ binding site.Journal of biomolecular Structure & Dynamics 06/2013; DOI:10.1080/07391102.2013.790849 · 2.98 Impact Factor
Article: Retinitis pigmentosa reduces the risk of proliferative diabetic retinopathy: a nationwide population-based cohort study.[Show abstract] [Hide abstract]
ABSTRACT: To study the association between retinitis pigmentosa (RP) and the progression of diabetic retinopathy (DR). Using the Longitudinal Health Insurance Database 2000 of Taiwan, we identified individuals with an initial diagnosis for RP during the period of 1997-2008. A non-RP comparison group, 10-fold frequency matched by sex, age, index year and the year of diabetes diagnosed, were randomly selected from the same database. The occurrence of DR was observed for all subjects until the end of 2009. The Kaplan-Meier curves were used to illustrate the cumulative probability of developing DR for the RP group and comparison groups. The hazard ratio (HR) of DR for the RP group relative to the comparison group was estimated using Cox proportional hazards model after adjusting for potential confounders. The Kaplan-Meier curves were not statistically significant different between the RP group and the comparison group. However, the RP group had a higher cumulative probability of developing DR during the first six to seven years. The cumulative probability kept increasing and became higher in the comparison group but remained unchanged in the RP group. The HR for the RP patients comparing with the comparison group was 0.96 (95% confidence interval (CI) = 0.43-2.14). Stratified by severity, RP was associated with a non-statistically significant reduced risk of proliferative DR (PDR) (HR = 0.70, 95% CI = 0.16-3.14). The HR for non-proliferative DR (NPDR) was 1.08 (95% CI = 0.40-2.86). In this study, RP was not statistically significant associated with the incidence of DR.PLoS ONE 09/2012; 7(9):e45189. DOI:10.1371/journal.pone.0045189 · 3.53 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: To investigate the risk factors and comorbidities associated with ethambutol-induced optic neuropathy (EON). Using the Taiwan Longitudinal Health Insurance Database, we conducted a study within a nationwide representative cohort of patients treated with EMB. We identified 231 patients newly diagnosed with EON between 2000 and 2008, and 924 control subjects. Adjusted OR by estimating the risk of EON in relation to comorbidities and EMB prescription protocol was determined. Compared with the control group, EON patients were at risk with older age, hypertension (adjusted OR=1.62, 95% CI 1.16 to 2.26) and renal diseases (without end-stage renal diseases (ESRD), adjusted OR=2.11, 95% CI 1.02 to 4.35; with ESRD, adjusted OR=3.73, 95% CI 1.79 to 7.74). Patients with an EMB prescription duration longer than 3 months were not at elevated risk compared with those whose prescription less than 3 months (OR=1.35, 95% CI 0.99 to 1.83, adjusted for age, sex, hypertension and renal diseases). Patients whose average daily dose was greater than 1200 mg, compared with the other two groups (800∼1199 mg, less than 800 mg) were not at increased risk for EON. Age, hypertension and renal diseases are risk factors for EON in the Taiwanese population.The British journal of ophthalmology 09/2012; 96(11):1368-71. DOI:10.1136/bjophthalmol-2012-301870 · 2.92 Impact Factor
Article: Comparison of Glaucoma Diagnoses Using Stratus and Cirrus Optical Coherence Tomography in Different Glaucoma Types in a Chinese Population[Show abstract] [Hide abstract]
ABSTRACT: PURPOSE:: To compare the glaucoma diagnostic power of Stratus and Cirrus optical coherence tomographies (OCTs) in a Taiwan Chinese population with different glaucoma types. PATIENTS AND METHODS:: One eye each was chosen from 21 ocular hypertension (OH) patients, 27 glaucoma-suspect (GS) patients, 35 primary open-angle glaucoma (POAG) patients, 26 primary angle-closure glaucoma (PACG) patients, and 52 normal subjects. Early glaucoma (EG) was identified among glaucomatous eyes on the basis of the visual field severity (better than -9 dB). All participants were imaged using 2 OCT units at the same visit. The area under the receiver operator characteristic (AROC) curve was used to differentiate normal eyes from OH, GS, POAG, PACG, and EG eyes, and the sensitivity and specificity of each parameter from internal normative classifications were analyzed. RESULTS:: For normal versus OH eyes, the best AROC value was the average thickness (Stratus, 0.693; Cirrus, 0.697). For normal versus GS eyes, the best AROC value was the average thickness (Stratus, 0.807; Cirrus, 0.776). For normal versus POAG eyes, the best AROC value was the average thickness (Stratus, 0.943; Cirrus, 0.930). For normal versus PACG eyes, the best AROC value was the 5-o'clock hour (Stratus, 0.830; Cirrus, 0.817). For normal versus EG eyes, the best AROC value was the average thickness with Stratus (0.868) and the 5-o'clock hour with Cirrus (0.876). All sensitivities in the 5 groups were fair on the basis of the internal normal classification database of both OCTs. CONCLUSIONS:: Cirrus and Stratus OCTs showed equal diagnostic power in EG, OH, GS, POAG, and PACG eyes in a Taiwan Chinese population. The utility of the current internal databases of both OCT units for the Chinese population is an interesting issue that needs to be addressed in the future.Journal of glaucoma 05/2012; 22(8). DOI:10.1097/IJG.0b013e3182594f42 · 1.74 Impact Factor
Article: Correlation between Stratus OCT and GDx VCC in early glaucoma, ocular hypertension and glaucoma suspect eyes[Show abstract] [Hide abstract]
ABSTRACT: PurposeTo study the correlation between Stratus optical coherence tomography (OCT) and scanning laser polarimetry (GDx VCC) in measuring retinal nerve fiber layer (RNFL) thickness in eyes with early glaucoma (EG), ocular hypertension (OH), and glaucoma suspect (GS) in a Taiwan Chinese population.Methods One eye each of 170 subjects (50 eyes with EG, 32 eyes with OH, 38 eyes with GS and 50 healthy eyes) was included. The RNFL thickness was measured by both technologies and three parameters (average, superior and inferior thickness) were correlated using the Pearson's correlation coefficient (r) in each group. Diagnostic capability of two instruments was evaluated in EG, OH and GS eyes based on the area under the receive operator characteristic (AROC) curve.ResultsIn healthy and EG eyes, three RNFL parameters were significantly correlated. In OH eye, there was no significant correlation in three parameters. In GS eye, there was significant correlation in inferior thickness only. For healthy vs EG eye, the best parameter with largest AROC was nerve fiber indicator (0.798) for GDx VCC and average thickness (0.787) for OCT. The diagnostic capability of two techniques is poor in OH (AROC, 0.510–0.645) and GS eyes (AROC, 0.510–0.689).Conclusion The RNFL thickness measured by OCT and GDx VCC was well correlated in EG and healthy eyes but poorly correlated in OH and GS eyes. When managing the case with OH or GS eye, we should be cautious in interpreting different imaging data.ResumenObjetivoEstudiar la correlación entre la tomografía de coherencia óptica (OCT) Stratus y la polarimetría láser de barrido (GDx VCC) en la medición del espesor de la capa de fibras nerviosas de la retina (CFNR) en ojos con glaucoma temprano (GT), hipertensión ocular (HO) y sospecha de glaucoma (SG) en una población de chinos taiwaneses.MétodosSe incluyeron 170 sujetos, un ojo de cada uno de ellos (50 ojos con GT, 32 ojos con HO, 38 ojos con SG y 50 ojos sanos). Se midió el espesor de la CFNR con ambas técnicas y se correlacionaron tres parámetros (espesor medio, superior e inferior) utilizando el coeficiente de correlación de Pearson (r) en cada grupo. Se evaluó la capacidad de diagnóstico de ambos instrumentos en ojos con GT, HO y SG basándose en el área bajo la curva de la característica operativa del receptor (AROC).ResultadosEn ojos sanos y con GT, se correlacionaron de manera significativa tres parámetros de CFNR. En los ojos con HO, no hubo correlación significativa en tres parámetros. En ojos con SG, hubo correlación significativa únicamente en el espesor inferior. Para ojos sanos frente a GT, el mejor parámetro con la mayor AROC fue el indicador de fibras nerviosas (0,798) en GDx VCC y el espesor medio (0,787) en OCT. La capacidad de diagnóstico de ambas técnicas es baja para ojos con HO (AROC: 0,510–0,645) y SG (AROC: 0,510–0,689).ConclusiónEl espesor de la CFNR medido por OCT y GDx VCC presentó una buena correlación en ojos con GT y sanos, pero muy baja en ojos con HO y SG. A la hora de tratar casos de ojos con HO o SG, deberemos ser prudentes al interpretar los diferentes datos de exploraciones por imagen.Journal of Optometry 01/2012; 5(1):24–30. DOI:10.1016/j.optom.2012.01.001
[Show abstract] [Hide abstract]
ABSTRACT: Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells. Hence, we employed Traditional Chinese Medicine Database (TCM Database@Taiwan) (http://tcm.cmu.edu.tw) to identify potential EGFR inhibitor. Multiple Linear Regression (MLR), Support Vector Machine (SVM), Comparative Molecular Field Analysis (CoMFA), and Comparative Molecular Similarities Indices Analysis (CoMSIA) models were generated using a training set of EGFR ligands of known inhibitory activities. The top four TCM candidates based on DockScore were 2-O-caffeoyl tartaric acid, Emitine, Rosmaricine, and 2-O-feruloyl tartaric acid, and all had higher binding affinities than the control Iressa®. The TCM candidates had interactions with Asp855, Lys716, and Lys728, all which are residues of the protein kinase binding site. Validated MLR (r² = 0.7858) and SVM (r² = 0.8754) models predicted good bioactivity for the TCM candidates. In addition, the TCM candidates contoured well to the 3D-Quantitative Structure-Activity Relationship (3D-QSAR) map derived from the CoMFA (q² = 0.721, r² = 0.986) and CoMSIA (q² = 0.662, r² = 0.988) models. The steric field, hydrophobic field, and H-bond of the 3D-QSAR map were well matched by each TCM candidate. Molecular docking indicated that all TCM candidates formed H-bonds within the EGFR protein kinase domain. Based on the different structures, H-bonds were formed at either Asp855 or Lys716/Lys728. The compounds remained stable throughout molecular dynamics (MD) simulation. Based on the results of this study, 2-O-caffeoyl tartaric acid, Emitine, Rosmaricine, and 2-O-feruloyl tartaric acid are suggested to be potential EGFR inhibitors.PLoS Computational Biology 10/2011; 7(10):e1002189. DOI:10.1371/journal.pcbi.1002189 · 4.83 Impact Factor
Top Journals
Tamkang University
T'ai-pei, Taipei, Taiwan
- Department of Mathematics
Asia University
臺中市, Taiwan, Taiwan
- Department of Biomedical Informatics
China Medical University Hospital
臺中市, Taiwan, Taiwan
- Department of Radiology
National Chin-Yi University of Technology臺中市, Taiwan, Taiwan
China Medical University (ROC)臺中市, Taiwan, Taiwan


text: Several lights weren't working and dishwasher would not come on Robert S. • Buford, GA • October 25, 2014 My Repair & Advice I found the ribbon cable from the controller to the control pad failed internally and the traces were broken. After replacing the control pad & ribbon cable, the dishwasher works normally. Was this review helpful to you?


text:
Lessons to be learnt from German experience with gender recognition
- Crime & Law
- February 16, 2015, 01:30
The Gender Recognition Bill 2014 has been criticised for several provisions which some people see as too restrictive and exclusionary. These include t(...)
Transgender recognition Bill 'flawed', human rights lawyers say
- Irish News
- February 3, 2015, 01:00
Leading human rights lawyers have described the Government's gender recognition Bill as "flawed" and "very disappointing" and have urged that it be br(...)
Disarray after veto on joining human rights convention
- Europe
- January 19, 2015, 01:15
In a surprise decision just before Christmas, the European Union's top court vetoed plans for the EU to sign up to the European Convention on Human Ri(...)
Archive of human rights activist to be unveiled at NUI Galway
- Irish News
- November 27, 2014, 01:01
When a young Co Down student visited Detroit at the height of the US civil rights movement in the early 1970s, he was struck by the treatment of black(...)
Lydia Foy settles transgender birth cert case against State
- Courts
- October 28, 2014, 12:27
Transgender woman Lydia Foy has effectively settled her long-running action against the State aimed at securing a birth certificate in her acquired fe(...)
Concussion on the political agenda
- Rugby
- October 3, 2014, 01:00
Concussion visited Leinster House yesterday. In many ways that in itself was a triumph. That legislators wanted to know about the newest, perhaps most(...)
More head injuries in A&E as concussion awareness grows
- Health
- October 2, 2014, 15:13
A sharp rise in the number of young people reporting to the emergency department at St Vincent's Hospital in Dublin with head injuries has been linked(...)
'Wonderful life' of Gordon Colleary recalled at his funeral
- Religion & Beliefs
- June 27, 2014, 17:09
American Catholic mystic Thomas Merton was quoted at the funeral of Gordon Colleary (73) whose funeral Mass took place at St Joseph's church in Dublin(...)
Hume's 1964 'Irish Times' articles helped redefine nationalist attitudes to North
- Politics
- April 28, 2014, 01:01
Fifty years ago, The Irish Times published a strong challenge to the nationalist consensus (...)
Thousands gather to remember Easter Rising in Dublin
- Religion & Beliefs
- April 20, 2014, 16:43
Minister of State Brian Hayes has said he "fundamentally disagrees" with those who say members of Britain's royal (...)


text:
Click on a thumbnail to go to Google Books.
The Chaperone (original 2012; edition 2012)
by Laura Moriarty
Work details
The Chaperone by Laura Moriarty (2012)
No current Talk conversations about this book.
plenty of turns and twists in this story about a mother with a little extra time on her hands that decides to accompany an aquaintances daughter to New York for a month long dance study. Morality, birth control, sexuality and acceptance of all different lifestyles and their restrictions come up in this turn of the century story.
Read this book once, and then re-read for a book club meeting. The story centers on Cora Kauffman Carlisle as she chaperones Louise Brooks oin NYC, and then Cora's life upon her return home. This is historical fiction: Louise Brooks' story is true but Cora's is fictional. Very detailed during the NYC stay, but following that it goes very fast through the years.
It would seem that Cora's role as chaperone to the difficult Louise in New York altered her complacent life forever. I believe that because Cora's life was so unusual from the start she was already more sensitive, mature and intelligent. Her peculiar marital situation and its accompanying loneliness made her more aware of nuances. It is in New York that she learns just why Louise is flirtatious, irascible, incorrigible, and irresponsible. The shock and pain she feels push her to re-examine most of the ridiculous social mores she was taught as a child.
Perhaps her life in Wichita would have eventually changed but the trip to New York acted as the catalyst, an exciting, eye-opening experience. New York tested and shifted Cora's feelings on parental love, sexuality, racism, responsibility, and caring for oneself.
I enjoyed reading The Chaperone but felt the second half of the book, after Cora returns to Wichita, was rushed and less realistic (she brings Joseph back with her?!).
All in all a good read.
Two women: Louise and Cora are thrown together in this story that travels from Wichita, KS to the bustle of New York City during the 1920's. Louise is Louise Brooks--destined to be a star but in this book a teenage dancer full of dreams. Cora is hired to be her chaperone, but she has ulterior motives for travelling to New York and secrets that no one--least of all Louise--would ever guess. As Louise bursts upon New York determined to experience all of the night life the city has to offer, Cora tries her best to fulfill her duties as a chaperone. She is distracted by the burning desire she has to find her birth mother, however, which is the real reason she wanted to come to New York. How her secrets do or do not come out, and the guidance she tries to give to the enigmatic Louise give this book a lot of tension and character that kept me turning the pages. Some of the revelations and tidy endings were a bit much to stomach, however. Still, I'd recommend this to fans of historical fiction who like tidy, happy endings and strong female characters.
This book was amazing!The characters were so well developed. I really liked how the story went all the way up to the end of Cora's life, too, not just dropped off at the end of chaperoning.
I listened to the audiobook, and the narrator did an amazing job.
References to this work on external resources.
Wikipedia in English
No descriptions found.
"A novel about the friendship between an adolescent, pre-movie-star Louise Brooks, and the 36-year-old woman who chaperones her to New York City for a summer, in 1922, and how it changes both their lives"--
(summary from another edition)
Amazon Kindle (3 editions)
Audible (1 edition)
CD Audiobook (4 editions)
Project Gutenberg (0 editions)
Google Books — Loading...
Popular covers
An edition of this book was published by Audible.com.
Penguin Australia
An edition of this book was published by Penguin Australia.
LibraryThing Early Reviewers Alumn
The Chaperone by Laura Moriarty was made available through LibraryThing Early Reviewers. Sign up to possibly get pre-publication copies of books.
Is this you?
Become a LibraryThing Author.


text:
Relevant offers
Two vehicles collided at the intersection of Muller Rd and Scott St in Blenheim on Tuesday morning.
Constable Andrew Holdaway said the accident happened about 9am when the driver of the vehicle in Muller St failed to give way to the vehicle travelling south along Scott St.
Neither driver was injured. The driver travelling in Muller Rd received an infringement notice for failing to give way.
- The Marlborough Express
Sponsored links
School kids help place memorial crosses for 59 war dead
Aerial poisoning of Para Wetlands ends
Marlborough District Council warns of toxic algae
Crashed cyclists 'overcooked' corners in the wet
WWI tanks leave Wellington on Cook Strait ferry
Trio accused of stealing school's iPads
Food stalls sizzling way to raise funds
Marlborough teens rise to the Cactus challenge
Art feeds the soul at Bread of Life
Marlborough is No 2 strong painkiller prescriber
Accused tells court he feared for his life
'Nothing sinister' in debate over Besley successor
Big April Fool is talk of the school
Judge: Wife just a bystander in drug operation
Galloway and Zeilinger go to a whole new level
French takes out caddie of the year
New Year's parties to have new organiser
Schools eye gay-straight support groups
Artist's work highlights festival history
Massey Ferguson rolls into Blenheim on big trip
Award 'icing on cake' for best Marlborough business
Big April Fool is talk of the school
Havelock hits the spot with BBC TV director
Accused tells court he feared for his life
NZ wine high on Top Gear team's demands
Judge: Wife just a bystander in drug operation
Marlborough is No 2 strong painkiller prescriber
Logging firm Waimea Contract Carriers calls in administrators
Baby (seal) sitters wanted for Ohau Point
Marlborough jobs at risk if transport firm closes
Is the region better served by having multiple events over one weekend or spread out throughout the year?Related story: (See story)