text:
OoT - Zelda's Lullaby [Re
Credits & Info
- Date
- 07/01/2009
- File Info
- Song
- 1 min 47 sec
- Score
- 4.38 / 5.00
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Licensing Terms
- Attribution:
- You must give credit to the artist.
- Noncommercial:
- You may not use this work for commercial purposes unless you make specific arrangements with the artist.
- Share Alike:
- If you alter, transform, or build upon this image, you may distribute the resulting creation only under a license identical to this one.
- Score:
- Rated 4.38 / 5 stars
- Plays & Downloads:
- 3,024 Plays | 301 Downloads
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- Genres:
- Electronic - Video Game
- zelda
- ocarina
- lullaby
- musicwizard
Author Comments
Rated 5 / 5 stars
It's a great remake of such a great song. The only word I can think of is majestic.
Rated 5 / 5 stars
so awesome
this is the most touching song i've ever heard in zelda history, and this remix made it even better than the original.*tears of joy and happyness*
Joy joy!
I am happy i could make someone happy with my music.
Rated 5 / 5 stars
lllooovvvee it
fucken bananas
Well, i am happy that you like it.
Rated 5 / 5 stars
Listening to it reminded me of the first time i'd ever played OoT. This remake of it has a lot more feel to it than the original does,so that's awesome.
Thanks again.
Yes, it's more open and got lots of warmth to it.
Rated 5 / 5 stars
Meep!~ This should be in the game. D:
Thanks a million.
If you like my Zelda remake, please do some damage by sending some recommendation emails to Nintendo and vote for me to be one of the composers for their games.


text:
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Tumor Necrosis Factor-a Induced Protein 8
Polymorphism and Risk of Non-Hodgkin's Lymphoma in
a Chinese Population: A Case-Control Study
Yan Zhang1,2, Meng-Yun Wang2,3, Jing He2,3, Jiu-Cun Wang4,5, Ya-Jun Yang4,5, Li Jin4,5, Zhi-Yu Chen1,2,
Xue-Jun Ma2,6, Meng-Hong Sun2,7, Kai-Qin Xia2,3,7, Xiao-Nan Hong1,2*, Qing-Yi Wei3,8, Xiao-
Yan Zhou2,3,7*
1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 2Department of Oncology, Shanghai Medical College, Fudan University,
Shanghai, China, 3Cancer Research Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China, 4Ministry of Education Key Laboratory of Contemporary
Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China, 5Fudan-Taizhou Institute of Health Sciences,
Taizhou, Jiangsu, China, 6Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 7Department of Pathology, Fudan University
Shanghai Cancer Center, Shanghai, China, 8Department of Epidemiology, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Background: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory
response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may
influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-
control study of 514 NHL patients and 557 cancer-free controls in a Chinese population.
Method: We used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six
previously reported inflammation and immune-related genes (TNF rs1799964T.C, LTA rs1800683G.A, IL-10 rs1800872T.G,
LEP rs2167270G.A, LEPR rs1327118C.G, TNFAIP8 rs1045241C.T). Logistic regression models were used to estimate odds
ratios (ORs) and 95% confidence intervals (95% CI).
Results: We observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C.T polymorphism
(adjusted OR=3.03; 95% CI=1.68–5.45 for TT vs. CC and adjusted OR=2.03; 95% CI=1.53–2.69 for CT/TT vs. CC). The risk
associated with the T allele was more evident in subgroups of 40–60 year-old, non-smokers or light-smokers (less than 25
pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin's lymphoma was
elevated for CT/TT genotypes (adjusted OR=1.95, 95% CI=1.41–2.70 for B cell NHL and adjusted OR=2.22, 95% CI=1.49–
3.30 for T cell NHL), particularly for DLBCL (adjusted OR=2.01, 95%CI=1.41–2.85) and FL (adjusted OR=2.53, 95% CI=1.17–
5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous
Conclusions: The polymorphism of TNFAIP8 rs1045241C.T may contribute to NHL susceptibility in a Chinese population.
Further large-scale and well-designed studies are needed to confirm these results.
Citation: Zhang Y, Wang M-Y, He J, Wang J-C, Yang Y-J, et al. (2012) Tumor Necrosis Factor-a Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's
Lymphoma in a Chinese Population: A Case-Control Study. PLoS ONE 7(5): e37846. doi:10.1371/journal.pone.0037846
Editor: Jose Angel Martinez Climent, University of Navarra, Center for Applied Medical Research, Spain
Received January 16, 2012; Accepted April 26, 2012; Published May 29, 2012
Copyright: ? 2012 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported by the funding from National Natural Science Foundation of China (30870985, 30973391) and the Ministry of Health
(201002007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
* E-mail: email@example.com (XYZ); email@example.com (XNH)
Non-Hodgkin's lymphoma (NHL) incidence rates have been
increasing in both developed and developing countries with about
355,900 new cases in the world annually [1]. In China, the most
common subtype of NHL is diffuse large B cell lymphoma
(DLBCL), whereas follicular lymphoma (FL) is less common than
in Western countries. Extranodal lesions and T/NK cell NHLs
(eg. Extranodal NK/T-cell lymphoma) appear to be more
common in China [2]. However, the exact causes of NHL remain
largely unknown. Some evidence has showed that immune
dysfunction may be one of the risk factors [3], and single
nucleotide polymorphisms (SNPs) in immune and inflammatory
response genes may play an important role in lymphomagenesis
TNF/LTA and IL-10 genes code for immunoregulatory
cytokines that can mediate inflammation, apoptosis and Th1/
Th2 balance [6,7], and they may be good candidate genes for
studying lymphomagenesis. The cytokines TNF-a and LT-a are
thought to influence lymphomagenesis through up-regulation of
pro-inflammatory and anti-apoptotic signals, possibly via the NK-
kB pathway [5]. Some evidence also showed that polymorphisms
PLoS ONE | www.plosone.org1 May 2012 | Volume 7 | Issue 5 | e37846
Page 2
in IL-10 may regulate TNF-a levels and thus contribute to
activation of the NK-kB pathway [8]. A pooled analysis including
7,999 NHL cases and 8,452 controls from 14 case-control studies
was carried out by InterLymph Consortium, which showed that
LTA 252A?G (rs909253), IL-1-3575T?A (rs1800890), and partic-
ularly TNF-308G?A (rs1800629) were associated with an increase
risk of DLBCL in non-Hispanic white populations [9]. Purdue et
al. reported that IL-10-3575T?A and TNF-863C?A (rs1800630)
were associated with an elevated risk of DLBCL in an Australian
case-control study [5]. A recent genome-wide association study
(GWAS) of FL has identified additional two variants in the 6p21
chromosomal region [10], which is the TNF gene location,
suggesting that genetic variants in these regions may influence
NHL susceptibility.
The tumor necrosis factor-a induced protein 8 (TNFAIP8)
family are newly identified proteins that are important for
inflammation and immune homeostasis [11]. They play roles in
anti-inflammation by negatively regulating T cell receptor (TCR)
and Toll-like receptor (TLR) signaling [12]. But the association
between TNFAIP8 polymorphisms and NHL risk has not been
reported so far, particularly in Chinese populations.
The circulating levels of adipocytokines, including adiponectin,
resistin and leptin may also alter immune system function and
chronic inflammatory response. Leptin has pro-inflammatory
properties and stimulates the growth of certain cancer cells as
well as circulating pro-inflammatory cytokines, such as TNF-a and
interleukin [13]. Associations between NHL and polymorphisms
in the leptin (LEP) and leptin receptor (LEPR) gene have also been
reported. Skibola et al. found that the LEP19G allele was
associated with an increased risk of NHL, particularly FL [14].
A similar result was reported by a UK study, in which the LEPR
223ArgArg genotype was shown to be associated with an increased
risk of FL among women [15].
To test the hypothesis that polymorphisms in inflammation and
immune-related genes (such as TNF, LTA, IL-10, LEP, LEPR and
TNFAIP8) may be associated with susceptibility to NHL, we
conducted a case-control study in a Chinese population and
genotyped six potentially functional SNPs in the above-mentioned
candidate genes.
Materials and Methods
Ethics Statement
The study was approved by the Institutional Review Board of
Fudan University Shanghai Cancer Center. Participation was
voluntary. All participants singed a written informed consent, and
all clinical investigation was conducted according to the principles
expressed in the Declaration of Helsinki consent.
Study Population
The study population was identified from histologically
confirmed NHL cases diagnosed and treated between June 2005
and September 2011 at Fudan University Shanghai Cancer
Center. All patients came from the Eastern China, including
Shanghai, Jiangsu Province and the surrounding regions. Enroll-
ment criteria included the following: Chinese Han ethnicity, HIV
antibody negative, and without a diagnosis of second primary
malignancy. All cases were classified and reviewed according to
the 2008 WHO classification of tumors of haematopoietic and
lymphoid tissues [16]. Of the 732 eligible cases, 514 (70.2%)
consented to participate in the study and provided blood samples.
Additionally, 557 cancer-free control subjects were all selected
from Taizhou Longitudinal Study (TZL) at the same time period.
All the control subjects were frequency matched to the cases on
age (according to cases' age groups by every 5 years) and sex. The
cancer-free controls were genetically unrelated ethnic Han
Chinese who were not selected from family members of patients
and had no blood relationship. All participants were all from
Eastern China, and there was a major geographical overlap
between the cases and controls. TZL was initiated in July, 2007, in
Taizhou, Jiangsu province of China, as described previously [17].
Data Collection
After signing a written informed consent, all cases and controls
were asked to provide a blood sample of about 2 ml and
completed a questionnaire. Cases were asked about information
including age, sex, ethnicity, status of smoking and drinking, the
height and weight before diagnosis. The controls were also asked
to recall the same questions prior to the recruitment date. A total
of 514 cases and 557 controls provided blood samples, but 121
(23.5%) cases and 22 (3.9%) controls did not provide information
about smoking and drinking, and 91 (17.7%) cases failed to give
the exact information of height and weight before diagnosis.
SNP Selection
We first screened five frequently reported (TNF, LTA, IL-10,
LEP, LEPR) and one newly identified (TNFAIP8) inflammation
and immune-related genes from published papers. We then
searched SNPs in these six genes by NCBI dbSNP database
(http://www.ncbi.nlm.nih.gov/) for all populations, and used
HapMap database (http://hapmap.ncbi.nlm.nih.gov/) to focus on
CHB (Han Chinese in Beijing, China) population. SNPinfo
(http://snpinfo.niehs.nih.gov/) website was used as a tool to
predict SNP functions. Potentially functional SNPs were defined to
fit at least three of following four criteria: (1) SNPs located at the
two ends of these genes, such as 59 near gene, 59 untranslated
region (UTR), 39 near gene or 39UTR; (2) the minor allele
frequency (MAF) was$5% in the Hapmap CHB population. (3)
SNP variation may affect transcription factor binding sites (TFBS)
activity in the putative promoter region (here defined as 2-kb
upstream from the first exon). (4) SNP may affect the microRNA-
binding sites activity. Then eight SNPs were identified (TNF
rs1799964T.C, LTA rs1800683G.A, IL-10 rs1800872T.G,
rs11064A.G). However, the linkage disequilibrium (LD) analysis
revealed that LEP rs2167270G.A and LEP rs4728096 T.C were
in quite high LD (r2=0.93), and TNFAIP8 rs1045241C.T and
rs11064A.G were also in LD with r2=0.85. As a result, we
selected following six potentially functional and representative
rs1800872T.G, LEP rs2167270G.A, LEPR rs1327118C.G,
TNFAIP8 rs1045241C.T) for further genotyping.
Genomic DNA was extracted from each blood sample by using
the Qiagen Blood DNA Mini Kit (Qiagen Inc., Valencia, CA)
according to the manufacturer's instructions. DNA purity and
concentration were determined by spectrophotometric measure-
ment of absorbance at 260 and 280 nm by a UV spectrophotom-
eter (Nano Drop Technologies, Inc., Wilmington, DE) and all are
All TaqMan assays for this study including the pre-designed
SNP-genotyping assay mix containing PCR primers and probes
were purchased from ABI (Applied Biosystems, Foster City, CA).
Genotyping were conducted on the ABI 7900HT detection system
(Applied Biosystems). To ensure the accuracy of genotyping
results, four negative controls (no DNA) and four duplicated
TNFAIP8 Polymorphism and NHL Risk
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Page 3
samples were included in each of the 384-well plates for the quality
control. The assays were repeated for 5% of the samples, and the
results were 100% concordant. The analyzed fluorescence results
were then auto-called into the genotypes using the built-in SDS2.2
software of the system.
Statistical Analysis
BMI was calculated as weight (kg) divided by the square of the
height (m). In this study, we used the BMI cutoff points as
suggested by the Cooperative Meta-Analysis Group of Working
Group on Obesity in China [18]. If BMI,18.5 kg/m2, the
individualsweredefined as
18.5#BMI#24.0 kg/m2was defined as normal weight and
BMI.24.0 kg/m2was defined as overweight. Smoking status
was divided into smokers and non-smokers by whether or not they
had smoked for more than one year. Those who drank alcoholic
beverages at least once a week for one year or more were defined
as alcohol users, while the others were non-users. Differences in
the distributions of the alleles and genotypes as well as
demographic characters, smoking status, alcohol use and BMI
between the cases and controls were evaluated by the Chi-square
test. The Hardy–Weinberg equilibrium (HWE) of genotype
distribution in the controls was tested by a goodness-of-fit Chi-
square test. Unconditional univariate and multivariate logistic
regression models were applied to calculate crude and adjusted
odds ratios (ORs) and 95% confidence intervals (95% CI). We
used the multiple imputation (MI) method by SAS 9.1 software to
handle missing covariate information. All covariates were imput-
ed, when calculated adjusted ORs, according to the distributions
of observed values of either cases or controls. All statistical tests
were two-sided, and P,0.05 was considered statistically signifi-
cant. All analyses were performed using SAS Software, version 9.1
(SAS Institute, Cary, NC).
lowerthan normalweight,
Characteristics of the Study Population
There were 514 NHL cases and 557 cancer-free controls
included in this study, whose DNA samples were available. The
frequency distributions of demographic and some selected
characteristics of the participants are shown in Table 1. There
was no statistical difference in the distributions of age and sex
between cases and controls because of frequency matching by
design. The mean age was 49.3 years for the cases (614.1; range,
15–85) and 49.6 years for the controls (613.5; range, 20–85;
P=0.895), and 64.0% of the cases and 63.4% of the controls were
male (P=0.830). The controls were more likely to be smokers and
alcohol users (P,0.0001 and P=0.0001, respectively) and have
higher BMI (P,0.0001) compared with the cases. Consequently,
smoking status, alcohol use and BMI were adjusted for in the
subsequent multivariate logistic regression analyses. Of the 514
cases, 336 (65.4%) were B cell lymphoma, and 178 (34.6%) were T
cell and natural killer (NK) cell lymphoma. After stratified, 233
(45.3%), 52 (10.1%), 51 (9.9%), 146 (28.4%), 32 (6.2%) were
DLBCL, FL, other B cell lymphoma, NK/T cell lymphoma, and
other T cell lymphoma, respectively. Of all cases, 322 (62.6%) had
an Ann Arbor Stage of I–II and 192 (37.4%) had a later Ann
Arbor Stage of III–IV.
Association between Selected SNPs and Risk of NHL
Genotype distributions of the selected six SNPs in cases and
controls and their associations with NHL risk are presented in
Table 2. All observed genotype distributions among controls
were in agreement with the Hardy–Weinberg equilibrium
(P=0.285 for rs1799964, P=0.777 for rs180683, P=0.872 for
rs1800872, P=0.733 for rs2167270, P=0.559 for rs1327118,
P=0.420 for rs1045241). Significant difference in the genotype
frequencies was observed between the cases and controls for
TNFAIP8 rs1045241C.T (P,0.0001). When the rs1045241CC
genotype was used as the reference, the CT heterozygous, TT
homozygous and combined CT/TT genotypes were associated
Table 1. Characteristics of Non-Hodgkin's lymphoma cases
and cancer-free controls.
Variables Cases No. (%)Controls No. (%) P-valuea
All subjects 514 (100) 557 (100)
Age (years)0.895
Median (Range) 50.5 (15–85)51.0 (20–85)
,40 129 (25.10)131 (23.52)
40–60 269 (52.33)299 (53.68)
.60 116 (22.57)127 (22.80)
Male329 (64.0)353 (63.4)
Female 185 (36.0)204 (36.6)
Smoking status
Smoker 101 (25.7)232 (43.4)
Non-smoker 292 (74.3)303 (56.6)
Missing121 22
0 292 (74.3)302 (56.4)
0–2564 (16.3) 171 (32.0)
.2537 (9.4)62 (11.6)
Missing121 22
Alcohol use0.0001
Yes58 (14.8) 134 (25.0)
No335 (85.2)401 (75.0)
Missing121 22
BMI (kg/m2)
Median 22.823.7
,18.529 (6.9)21 (3.8)
18.5–24.0 253 (59.8)273 (49.0)
.24.0141 (33.3) 263 (47.2)
Missing 910
B cell lymphoma 336 (65.4)–
Other B cell
51 (9.9)–
T cell lymphoma 178 (34.6)–
Other T cell
32 (6.2)–
Ann Arbor Stage–
aP value of the comparison with a two-sided Chi-square test.
TNFAIP8 Polymorphism and NHL Risk
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Page 4
with significantly increased risk of NHL (adjusted OR=1.88;
95% CI=1.39–2.53 for CT heterozygous genotype, adjusted
OR=3.03; 95% CI=1.68–5.45 for TT homozygous genotype,
adjusted OR=2.03; 95% CI=1.53–2.69 for CT/TT genotype)
after adjustment for age, sex, BMI, smoking and drinking status.
However, no significantly altered NHL risk was found for variant
genotypes of the other five SNPs compared with their common
genotypes. We also evaluated the combined effect of all the six
SNPs. We had divided the subjects into seven groups according
to the number of combined variant genotypes. The ''0'' risk
genotype group was used as the reference, and unconditional
logistic regression models were applied to calculate OR and
95%CI for each group. But we did not find any significant
association between the combined effect of these six SNPs and
risk of NHL (data not shown).
Stratified Analysis
We further evaluated the association between the six candidate
SNPs and risk of NHL by subgroups of age, sex, smoking status,
alcohol use, BMI, common subtypes and Ann Arbor stage. No
statistical significances were found for the SNPs except TNFAIP8
rs1045241 C.T. The stratified analysis results of TNFAIP8
rs1045241 C.T are presented in Table 3. In general, an
increased risk associated with rs1045241 CT/TT genotypes was
more evident in subgroups of 40–60 year-old individuals (adjusted
OR=1.90, 95% CI=1.35–2.68) or smoked less than 25 pack-
years (adjusted OR=2.45, 95% CI=1.32–4.54), and normal
weight (adjusted OR=1.76, 95% CI=1.23–2.52) or overweight
groups (adjusted OR=2.07, 95% CI=1.32–3.25). Moreover, the
patients with rs1045241 CT/TT genotypes were associated with
Table 2. Genotypes distributions of the selected functional polymorphisms among NHL cases and cancer-free controls and their
associations with NHL risk.
Cases Controls
P Crude OR (95% CI)P Adjusted ORa(95% CI)P
TNF rs1799964T.C 0.590b
CT/CC199 38.7199 35.7 0.312c
1.14 (0.89–1.46) 0.312 1.06 (0.80–1.41)0.667
LTA rs1800683G.A 0.238b
AG/AA389 75.739671.1 0.090c
1.26 (0.96–1.66)0.090 1.30 (0.96–1.78)0.094
IL-10 rs1800872T.G 0.279b
GT/GG288 56.0288 51.7 0.156c
1.19 (0.94–1.51) 0.1561.28 (0.97–1.68) 0.083
LEP rs2167270G.A 0.801b
AG/AA 19237.4219 39.30.509c
0.92 (0.72–1.18) 0.5090.93 (0.70–1.23)0.607
LEPR rs1327118C.G0.769b
CG/GG 12424.1 14526.00.472c
0.90 (0.69–1.19)0.473 0.94 (0.68–1.29)0.705
TNFAIP8 rs1045241C.T
, ,0.0001b
, ,0.0001
CT/TT 22143.0 17631.6 0.0001c
1.63 (1.27–2.10) 0.00012.03 (1.53–2.69)
, ,0.0001
Statistically significant results (P,0.05) are highlighted in bold.
aORs were obtained from logistic regression models with adjustment for age, sex, smoking status, alcohol use and BMI.
bTwo-sided Chi-square test for distribution of three genotypes.
cTwo-sided Chi-square test for distribution of combined genotypes.
TNFAIP8 Polymorphism and NHL Risk
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Page 5
risk of both B and T cell lymphoma (adjusted OR=1.95, 95%
CI=1.41–2.70 and adjusted OR=2.22, 95% CI=1.49–3.30,
respectively). After stratifying by histological subtypes, we observed
increased risk for DLBCL (adjusted OR=2.01, 95%CI=1.41–
2.85) and FL (adjusted OR=2.53, 95%CI=1.17–5.45), but no
significant association was found for NK/T cell lymphoma
(adjusted OR=0.79, 95%CI=0.27–2.33). However, after we
verified homogeneity assumption by using a Chi square-based Q-
test. The results indicated that an increased NHL risk associated
with CT/TT genotypes was particularly more pronounced only in
subgroups of 40–60 year-old (P=0.03), and patients with a later
Ann Arbor stage of III–IV (P=0.04).
Genetic polymorphisms in immune-related genes that regulate
the immune and inflammation response may play an important
role in the incidence of NHL [19,20]. In this case-control study,
we reported that TNFAIP8 rs1045241C.T was significantly
associated with an increased risk of NHL in a Chinese population.
Stratified analyses revealed that subgroups of 40–60 years, non-
smokers or light-smokers (#25 pack-years), subjects with normal
weight or overweight were more likely to have been diagnosed
with NHL, especially the subtypes of DLBCL and FL. According
to epidemiologic data about NHL in China, the main subtypes of
lymphoma are DLBCL, FL and NK/T lymphoma, and other
subtypes have a small sample size, and therefore we only analyzed
the dominant subtypes of the cases. These results support the
Table 3. Stratification analysis of the association between TNFAIP8 rs1045241C.T and NHL risk.
CT+ +TT (cases/
CC (cases/
n%n% Crude Adjustedb
All subjects221/176 43.0/31.6293/381 57.0/68.40.0001 1.63(1.27–2.10) 2.03(1.53–2.69)
Age (year) 0.030
,40 56/4243.3/32.1 73/8956.6/67.9 0.2591.63(0.98–2.70) 1.43(0.77–2.67)
40–60119/8144.2/27.1 150/21855.8/72.9
, ,0.0001 2.13(1.50–3.03) 2.99(2.03–4.43)
.60 46/53 39.7/41.770/74 60.3/58.30.8400.92(0.55–1.53) 0.94(0.51–1.72)
Male 143/10643.5/30.0 186/24756.5/70.00.00031.79(1.31–2.45) 2.09(1.46–3.01)
Female78/7042.2/34.3 107/13457.8/65.7 0.0061.39(0.92–2.10) 1.91(1.21–3.04)
Smoking status0.060
Never 137/10146.9/33.7 155/201 53.1/66.30.0008 1.76(1.26–2.45)1.90(1.35–2.68)
#25 pack-year 31/47 48.4/27.533/12451.6/72.5 0.00242.48(1.37–4.49) 2.45(1.32–4.54)
.25 pack-year 18/2148.6/33.9 19/41 51.4/66.10.145 1.85(0.81–4.25)2.06(0.85–5.02)
Missing35/7 28.9/31.886/15 71.1/68.2–––
Drinking status0.360
Yes29/3850/28.4 29/9650/71.6 0.0042.53(1.34–4.78)2.66(1.36–5.19)
No 157/13146.9/32.7 178/27053.1/67.3
, ,0.00011.82(1.35–2.45) 1.88(1.37–2.58)
BMI(kg/m2) 0.240
,18.5 9/431.0/19.120/1769.0/80.90.3401.91(0.50–7.33) 1.62(0.37–7.05)
18.5–24.0 117/9346.2/34.1 136/18053.8/65.9 0.00441.67(1.17–2.37)1.76(1.23–2.52)
.24.0 70/7949.6/30.0 71/18450.4/70.0
, ,0.00012.30(1.51–3.50)2.07(1.32–3.25)
Missing 25/027.5/0 66/072.5/0–––
Ann Arbor Stage 0.040
B cell NHL140/17641.7/31.6 196/38158.3/68.40.0021.55(1.17–2.05)1.95(1.41–2.70)
T cell NHL81/17645.5/31.6 97/381 54.5/68.40.0007 1.81(1.28–2.55)2.22(1.49–3.30)
Statistically significant results (P,0.05) are highlighted in bold.
aP value of the comparison with a two-sided Chi-square test.
bORs were obtained from logistic regression models with adjustment for age, sex, smoking status, alcohol use and BMI.
cP value of the heterogeneity assumption with a Chi-square-based Q-test.
TNFAIP8 Polymorphism and NHL Risk
PLoS ONE | www.plosone.org5 May 2012 | Volume 7 | Issue 5 | e37846
Page 6
hypothesis that some polymorphism in inflammation and immune-
related genes may be associated with risk of NHL and its common
TNFAIP8, also known as GG2-1, MDC-3.13, SCC-S2, is located
on chromosome 5 (5q23.1). It was first identified in a human head
and neck squamous cell carcinoma (HNSCC) cell line [21].
Recently, it has been reported to be associated with oncogenesis,
immunity, and inflammation in several studies [11,12,22].
TNFAIP8 mRNA over-expression has been found in various
malignant cell lines, such as breast cancer [23], non-small cell lung
cancer [24], and esophageal squamous cell carcinoma [25].
Evidence showed that TNFAIP8 expression was upregulated by
TNF-a induced NF-kB pathway activation in cancer cell lines,
which can inhibit caspase-8 and reduce apoptosis [26,27]. Tumor
necrosis factor-a induced protein 8-like 2 (TIPE2), a member of
the TNFAIP8 family, was originally identified as a gene
abnormally expressed in the inflamed spinal cord of mice with
experimental autoimmune encephalomyelitis [12]. TIPE2-deficent
mice were more likely to suffer from chronic inflammation diseases
and multiple organ inflammation [12]. In humans, the abnormal
expression of TIPE2 was associated with systemic autoimmunity
[28], diabetic nephropathy [29], and hepatitis B [30]. These
studies supported that TIPE2 plays an important role in
maintaining immune homeostasis.
However, fewer studies have focused on the association between
polymorphisms of TNFAIP8 and NHL risk. The SNP TNFAIP8
rs1045241C.T included in the present study is located on the
39UTR of TNFAIP8, and the SNP function prediction shows that
it may affect the microRNA-binding sites activity (http://snpinfo.
niehs.nih.gov/snpfunc.htm). Some evidence has indicted that a
genetic polymorphism in a microRNA target site influence
transcriptional and post-transcriptional gene expression in cancers
[31]. Though we found that rs1045241C.T was associated with
the risk of NHL, the exact mechanisms of this relationship
remained unknown. Further functional studies have been
conducting to confirm our results.
In the present study, we did not find any significant association
between the investigated polymorphisms of TNF rs1799964T.C,
rs2167270G.A, LEPR rs1327118C.G and NHL risk in a
Chinese population. However, many pieces of evidence have
shown that other SNPs in these genes like TNF–308 G.A
(rs1800890), LEPR 233Q.R (rs1137101) increased the risk of
NHL, particularly DLBCL in non-Hispanic white populations
[9,14,15,32,33]. Our studies did not cover these SNPs because
their MAF was ,5% in CHB population according to Hapmap
database (http://hapmap.ncbi.nlm.nih.gov/). But Xiao et al.
reported that no association between TNF–308, LTA 252
polymorphisms and histological subtypes, disease stages in Chinese
NHL patients [34]. We believe that this inconsistency may be due
to ethnic and demographic differences between Chinese popula-
tions and white populations as well as the smaller sample size that
may also have led to insufficient statistical power. So our results
need to be replicated in additional studies in different populations
with large sample sizes.
Fewer studies reported an association between LEP 19 A.G,
LEPR 233Q.R and risk of NHL in Chinese populations, though
some previous published studies revealed that obesity was a risk
factor of NHL in developed countries [35]. Obesity may play the
role of inducing lymphomagenesis by the co-effects of LEP 19
A.G, LEPR 233Q.R polymorphisms and immune dysfunction
[14,15,36]. Inconsistently, we found the NHL cases were more
likely to have lower BMI compared with the cancer-free controls
(P,0.0001). One possible reason may due to ethnic difference in
BMI and its contribution to lymphoma. It is likely that populations
of developing and developed countries have different body size,
and Asians have lower BMI than Westerners. Thus the Chinese
standard of obesity was applied to the subjects in this study, but
obesity did not appear closely related to lymphomagenesis.
However, another possibility was that obesity may not a direct
risk factor for NHL in Chinese populations. There may be some
intricate interaction among obesity, diet, hormone, genetics, and
susceptibility to NHL but the present study did not have enough
power to detect such interactions. Further larger, transcontinental
studies are needed to fully explore and elaborate the extent of such
In the stratified analyses, the risk effect of the TNFAIP8
rs1045241 CT/TT genotype was more evident in subgroups of
40–60 year-old, non-smoker or light-smoker, and normal BMI or
overweight. Stratifying by subtypes and stage, the risk effect of
rs1045241 CT/TT genotype was evident for both B and T cell
lymphoma, especially for DLBCL and FL as well as later Ann
Arbor Stage of ?–?. But we noticed that after verification of
homogeneity assumption, only age and stage showed marginally
statistical significance. So, there was no strong evidence of an effect
between the selected covariates and NHL risk. The exact
association between selected covariates and NHL risk needs to
be further investigated by large studies. Up to now, there is still
inconsistence about the effect of smoking, alcohol use, and BMI on
NHL risk, and the mechanisms are multiple. Wang et al. once
reported that autoimmune conditions, obesity, and later birth
order could contribute to lymphomagensis through an alteration
of the proinflammatory pathway, specifically involving common
genetic variants in TNF and IL-10 [8]. Given the results of our
study, NHL development may be of complex process that includes
a great number of events. A single factor would have a limited
effect on the susceptibility. Once the exposure of environmental
factors was accumulated to a certain level, alteration took place in
immune and proinflammatory pathways, and genetic variants or
other unknown events may also participate in the process. On the
other hand, our study was not large enough, and possible selection
bias may exist due to a higher-than expected non-response rate in
case group. Well-designed large studies are needed to test the
hypothesis that TNFAIP8 polymorphisms may influence NHL
susceptibility, particularly by the possible interactions with
environmental risk factors.
Several limitations exist in the present study. First, the sample
size was not large enough, so selection bias may be inevitable, and
the study did not provide enough statistical power to detect gene-
gene and gene-environment interaction. Second, we selected only
one functional SNP for each candidate gene, which restricted
further analysis to identify other potentially important associations.
Moreover, different histological subtypes of NHL, such as
DLBCL, FL, and NK/T cell lymphoma may have different risk
factors and etiologies. We did not have enough information about
environmental exposure from NHL patients, such as use of hair
dye, family history of NHL, occupation and EB-virus infection to
be included in stratified analyses.
In summary, we identified TNFAIP8 rs1045241C.T to be
associated with risk of NHL in a Chinese population, particularly
DLBCL and FL. To the best of our knowledge, this is the first
study to report a TNFAIP8 polymorphism associated with NHL
susceptibility in a Chinese population, which provides additional
evidence that inflammation and immune-related genetic polymor-
phisms play an important role in lymphomagenesis. Further large-
scale well-designed population-based studies are needed to validate
TNFAIP8 Polymorphism and NHL Risk
PLoS ONE | www.plosone.org6 May 2012 | Volume 7 | Issue 5 | e37846
Page 7
our findings, define the high-risk population and deepen our
understanding of NHL pathogenesis.
We thank Yan-Zi Gu, Huan Chen, Ting-Yan Shi, and Mei-Ling Zhu for
their help in collecting blood samples and DNA extraction, and Yu-Hu
Xin for his assistance in technical support.
Author Contributions
Conceived and designed the experiments: XYZ. Performed the experi-
ments: YZ KQX. Analyzed the data: YZ MYW JH. Contributed reagents/
materials/analysis tools: JCW YJY LJ ZYC XJM MHS QYW. Wrote the
paper: YZ XYZ QYM. Supplied clinical information: XNH.
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X. Li, G. Li, Z. Gao, X. Zhou, Zhu X (2011) The relative frequencies of
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29. Zhang S, Zhang Y, Wei X, Zhen J, Wang Z, et al. (2010) Expression and
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ogy 48: 1203–1208.
31. Yu Z, Li Z, Jolicoeur N, Zhang L, Fortin Y, et al. (2007) Aberrant allele
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32. Skibola CF, Bracci PM, Nieters A, Brooks-Wilson A, de Sanjose S, et al. (2010)
Tumor Necrosis Factor (TNF) and Lymphotoxin- (LTA) Polymorphisms and
Risk of Non-Hodgkin Lymphoma in the InterLymph Consortium. American
Journal of Epidemiology 171: 267–276.
33. Wang SS, Purdue MP, Cerhan JR, Zheng T, Menashe I, et al. (2009) Common
Gene Variants in the Tumor Necrosis Factor (TNF) and TNF Receptor
Superfamilies and NF-kB Transcription Factors and Non-Hodgkin Lymphoma
Risk. PLoS One 4: e5360.
34. Xiao H, Zhang K (2010) Genetic polymorphisms of tumor necrosis factor-a and
lymphotoxin-a in Chinese patients with non-Hodgkin lymphoma. Annals of
Hematology 90: 725–727.
35. Larsson SC, Wolk A (2007) Obesity and risk of non-Hodgkin's lymphoma: A
meta-analysis. International Journal of Cancer 121: 1564–1570.
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lymphoma. Blood 117: 585–590.
TNFAIP8 Polymorphism and NHL Risk
PLoS ONE | www.plosone.org7May 2012 | Volume 7 | Issue 5 | e37846

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Capita selected by John Lewis
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17 March 2014
Capita has been selected by John Lewis to provide its online contact centre. Under the agreement, which is worth £93.5m over five years, Capita will support John Lewis' online growth strategy.
Capita will deliver a digital service, built around John Lewis' customers, that integrates with the full range of customer contact channels.
Capita plc Chief Executive, Andy Parker, said: "The John Lewis brand is synonymous with excellent customer service and brand loyalty. It is only natural that the company wants to use the latest technology and service design methods to deliver an enhanced experience to its customers, and make it even easier for them to engage with the brand. Capita has extensive experience of working with household names from across the private sector, including major retailers. We appreciate the importance of becoming fully immersed in a company's brand values to ensure that customer experience is at the heart of service delivery."
"The online contact centre will stay in Glasgow, demonstrating Capita's ongoing commitment to investing in Scotland and supporting the growth of the local economy. Capita already employs around 5,000 people in Scotland and we anticipate that this figure will rise by around 2,000 in the next two years."
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Thank you for reviewing the last chapter. My stories seem to have a 'world of their own'.
I rubbed my stomach as another grumble resounded through my room. After getting chewed out more than twice, I didn't want to provoke the Praetorian's anger. She had already warned me once not to attempt escape and go over to the alcove. Outside of my room, it was very quiet. I wondered if they were asleep and I stood up and went to the door. I stood in the door frame, pondering how to get the 'right' attention from the Praetorian.
"Um." I said timidly. "Hello? Anyone out there?"
My voice echoed. I shook my head, feeling stupid. "Look! I'm not going anywhere until I get a straight forward answer!" I yelled, my voice echoing off the walls and through the corridor. "Hey! I'm talking to you! I know you're out there!" I heard shuffling. "I can hear you out there! I'm not deaf!"
The shuffling stopped. I looked around for the Praetorian. "No name alien lady?" I asked. "Is that you?"
No response.
"Ha ha! That's funny!" I said, looking at the small spidery thing skittering across the floor. Then it stopped and turned to me. I began to feel a little nervous and began retreating into the room, "Um, you go ahead and go find something else."
Then suddenly, it leaped into the air, it's spider-like legs extended to me. I let out a startled shriek when the Praetorian emerged in front of me with a hiss at the spider thing. I jumped back and landed unceremoniously onto the webbed bed. It swung back and forth like a hammock. I struggled to stop it from swinging back and forth.
The Praetorian hissed at the spider and it scampered off out of my room and I lay there. The Praetorian turned her head to me and sniffed me. "I'm fine."
"Those are called 'Face-huggers'. They clasp onto your face, forcing you to open your-"
Instead of acknowledging her, I stared at her in shock for a minute before launching myself into the Praetorian's arms. "I'm sorry! I really am! I didn't know you were still here!"
The Praetorian hissed, feeling weird. Humans rarely showed any emotion except to scream when they burst forth from their hosts. The Praetorian felt a different feeling toward the human. The Praetorian sensed something off within the human. There were old injuries. The Praetorian gently pried the human off her to sniff her front. The human tensed and tried to squirm from her clawed grasp.
"You're hurting me."
The Praetorian released her and stiffened. "Who did this to you?"
"It's the past."
"You have injuries! Who did this and do not lie!"
"I deserved it. I was a bad girl-"
"No one deserves any type of punishment or injuries. WHO did this?"
"My foster parents."
"If they come looking for you, you will be protected at all costs." Another voice cut in through my thoughts. I jumped when I realized that the Queen had heard through the Praetorian.
"So I'm here to stay?" She asked.
The Praetorian looked at her and turned to leave, but the girl's voice stopped her. "Wait! I-I'm hungry. Could I go have something to eat?"
"Remain here. I will be back soon."
"Are you going to the ship?"
"Yes. There is food there."
"Let me come. I don't want to be alone. I'll stay next to you."
"Very well."
"Really? I can go?"
"Yes. If you do what we tell you."
"Great! Thanks."
The Praetorian gestured to her back. The girl climbed up on her back and settled herself between the shoulder blades. She clutched them tightly. "Loosen your grip." She felt the grip relax. Then the Praetorian ran through the corridors, followed by several drones.
"How come they're coming?"
"Gathering team."
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Kimpton Appoints New Marketing Manager of FL Portfolio
Thursday August 29th, 2013 - 9:27AM
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MIAMI—Biby Banna has been hired as the new marketing manager for Kimpton Hotels & Restaurants' Florida portfolio. This includes the EPIC Hotel; Surfcomber Miami, South Beach; and Vero Beach Hotel & Spa.
In her new role, Banna will lead marketing and social media initiatives to drive sales, develop packages and promotions and manage social media content, among other duties.
Banna's past experience includes a role as the content and marketing manager at Gustazos Social Media, Inc. Prior hotel experience includes a stint with Sheraton. In 2010, Banna was named sales and marketing coordinator at Sheraton Puerto Rico Hotel and Casino. After two years, she transitioned to business development and lead generator at the Sheraton Denver Downtown.
Banna graduated with a Bachelors degree in microbiology from George Washington University. She earned her sales and marketing certification from Sagrado de Corazon University in Puerto Rico.
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Technology used to be considered impersonal. You know, the idea of the "robotic mind," no human interaction. But, the reality is technology is actually very personal and becoming more so by the day. Devices are so in sync with their users, they've become the personal secretaries to the masses. This is even more true when talking connected wearables.
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March 2015 Issue
Six Strategies for Being More Skillful in Influencing Others
The most successful school leaders don't lead by the authority of their position alone. They rely on a toolbox of skills to influence the diverse group of stakeholders with whom they work in order to gain commitment and support for their ideas. Communications expert Jennifer Abrams joins us to provide six strategies that will enable school leaders to be more skillful in influencing others. Continue
Leveraging Social Media to Engage with Parents and Communities
Technology and web tools give school leaders remarkable leverage to connect beyond the walls of the school building, but few schools really leverage the full power of social media to engage school stakeholders. To talk about the benefits of engaging more fully with parents and community, we're joined by social media expert Brad Currie, author of All Hands on Deck: Tools for Connecting Educators, Parents, and Communities. Continue
How Expert Principals Make Difficult Decisions
On a daily basis, principals are called on to make complex decisions, manage crises, and navigate tough choices. What factors do expert principals take into account when making difficult decisions? Dionne McLaughlin, an experienced former principal and author of Insights: How Expert Principals Make Difficult Decisions, joins us to discuss. Continue
Rethinking Purchasing: A Strategic Approach to Spending Money Wisely
The process by which schools purchase materials, supplies and equipment represents a real opportunity for school leader to spend their budgets more strategically and stretch existing dollars. Jim Smith, co-author of the book Spending Money Wisely joins us to provide a variety of strategies and tips that can help lead to significant savings for districts and schools. Continue
Confronting the Change Challengers: Getting Support for New Initiatives
While the majority of teachers are eager to embrace change that leads to school improvement, there are always those who, for many reasons, resist change. It's vitally important that school leaders address these "change challengers," though, because they can otherwise undermine new initiatives. To address the topic we're joined by Cathie West, an award winning and distinguished former principal. Continue
Leadership Coaching for School Leaders
Karla Reiss, award-winning author of Leadership Coaching for Educators: Bringing Out the Best in School Administrators, joins us to explain how coaching can yield powerful results for schools and why the key to making change stick is for every school leader to develop competent coaching skills and understand how to adopt a coaching style of leadership. Continue


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Our special coverage of the closest race for years
Explore the personal stories of Syrian refugees in Lebanon
11 Jan 2011 00:46 GMT | Politics, US & Canada, United States
Tom DeLay, a Republican legislator, has been sentenced to a three-year prison term after a jury convicted him for money laundering and conspiracy.
Senior judge Pat Priest sentenced DeLay, the former majority leader in the House of Representatives, to five years for money laundering and three years for conspiracy in a scheme for a political campaign.
"Before there were Republicans and Democrats there were Americans," said the judge, adding that America is "about the rule of law".
"Judge, I can't be remorseful for something I don't think I did. I fought the fight, ran the race and kept the faith"
Tom DeLay, former House majority leader
Priest, in handing down the sentence on Monday, allowed DeLay to serve 10 years probation in lieu of the five-year term, but ordered him to serve the three-year term with no probation.
The ruling was issued after a brief sentencing hearing in which Dennis Hastert, the former US House Speaker, testified on DeLay's behalf.
DeLay was immediately taken into custody, but the judge granted a request from his lawyers that he be released on a $10,000 bond, pending appeal once he is processed at the county jail.
Dick DeGuerin, DeLay's lawyer, said he plans to appeal the conviction and the sentence, adding: "This will not stand".
DeLay was found guilty on November 24 of conspiring to illegally funnel $190,000 in corporate campaign donations to Republican candidates for the Texas legislature in 2002 elections.
No remorse
"Judge, I can't be remorseful for something I don't think I did," DeLay said at the hearing before the sentencing. "I fought the fight, ran the race and kept the faith."
DeLay, a former Houston-area congressman, said the campaign contributions were legal and that the charges were trumped up by Democrats.
Prosecutors said DeLay's sentence was appropriate.
"Corporate contributions are illegal in Texas, and you can't give them to candidates directly and you can't give them to candidates indirectly," said Rosemary Lehmberg, the Travis County district attorney.
DeLay, a former owner of a pest control company, was elected to the House of Representatives in 1984 and rose eventually to the position of deputy speaker, earning a reputation as a master vote-counter and prolific fundraiser.
In 1994, he was part of a "Republican Revolution" that won control of the House for the first time in 40 years.
DeLay resigned from the House in 2006 after links to Jack Abramoff, a former Republican lobbyist snared in a federal investigation of influence peddling on Capitol Hill, became public.
Two of DeLay's ex-aides pleaded guilty to corruption. Delay denied any wrongdoing.
Source: Agencies
A Texas jury finds former US Republican leader guilty of illegally funnelling money to political candidates.
Politics, Business & Economy, US & Canada, United States
Mired in a political scandal, Tom DeLay, the US House of Representatives' former majority leader, has said he will quit the US Congress by mid-June.
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Trash is a fast-growing import in the Scandinavian country, which turns it into heat for people's homes.
Environment, Europe, Sweden
Critics say the UK's home secretary is using Muslims as a 'political punchbag' in a bid to shore up right-wing support.
Human Rights, Politics, Racism
2014 was the worst year in more than a decade for polio infections, with at least 306 new cases reported.
Polio, Asia, Pakistan
Recent court ruling finds police unit not guilty of rounding up and executing 42 Muslim men during 1987 communal riots.
Human Rights, India, Asia
Clashes continue in Yemen's coastal city, as bombing by Saudi-led coalition targets Houthis' air-defence capabilities.
War & Conflict, Politics, Yemen, Middle East
Iraqi troops say battle to retake city will not be easy, with areas "littered with bombs and booby-traps".
War & Conflict, Politics, Middle East, Iraq, ISIL
It is a source of sustenance but also of tension and new political realities are now increasing uncertainty.
Egypt, Sudan, Middle East
A media post-mortem into the UK's surveillance report. Plus, why five years on in Argentina the media looks so familiar.
Media, Edward Snowden, Security
The untold story of how the Lebanese community overcame the odds and found their place in multicultural Australia.
Asia Pacific, Australia, Lebanon
How to keep a telenovela profitable and demanding sponsors happy while inspiring the production team to stay passionate.
Arts & Culture, Mexico, Latin America


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SOUTH BEND, Ind. -- A harsh geography lesson came for Justin Utupo five years ago upon receiving his boarding pass for a flight to South Bend.
SOUTH BEND, Ind. -- This can't be how Cam McDaniel expected to feel before his last home game at Notre Dame.
Comcast SportsNet Chicago will have cameras covering the biggest IHSA state playoff games across Chicagoland on High School Lites, Saturday at 11:00 p.m.
Notre Dame's loss at Florida State looks like the high point of 2014.
Between the injuries, the constant lineup shuffling, the defensive lapses and the on-going questions about Derrick Rose's health, there have been ample opportunities for the Bulls veteran players


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Check out the new, mobile-friendly WineSpectator.com!
July 31, 1994 Hail Caesar This 70-year-old garlic-laced salad from Tijuana has conquered the culinary world By Sam Gugino Though the name might conjure up visions of ancient Rome in some minds, most people assume that Caesar salad was invented by an American, albeit perhaps an Italian-American.
For the full article, check out the new issue of Wine Spectator, on newsstands July 31, 1994.
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A Single-Symbol-Decodable Space-Time Block Code with Full Rate and Low Peak-to-Average Power Ratio
Free registration required
Executive Summary
Three desirable properties of a four-antenna space-time block code are full rate, full diversity, and single-symbol decodability. Previously reported space-time codes that achieve all three properties do so at the expense of the Peak-to-Average Power Ratio (PAPR). A fourth desirable property of a space-time block code is that its PAPR be the same as that of the underlying quadrature-amplitude modulation alphabet. In this paper the authors introduce space-time codes for three and four transmit antennas that achieve all four properties; these codes use a diversity technique based on constellation stretching. Numerical results for quasistatic Rayleigh-fading channels show that, despite their low PAPR, the proposed codes are comparable in SNR performance to the best-performing single-symbol decodable space-time codes for three and four transmit antennas.
- Format: PDF
- Size: 315.07 KB


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Tom's Hardware To Cardmakers : Game Over 49
from the hardware-reviewer-breaks-free-of-chains dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
Which car review would you put more stock in - the one written by a person who got to take the car home for a couple of weeks and subject it to regular daily usage, or the one written by the guy who got to drive it around the block twice while the salesguy was sitting right next to him? I mean, if all you want is info as fast as possible and you really don't care about the source, well, both ATI and nVidia put their press releases on their websites - just bookmark those pages and call it a day.
I've stopped reading hardware "review" and "enthusiast" sites, as I can get the same pathetic excuses for insights straight from the manufacturer'
When the price and performance of two cards are almost equal (which is true most of the time between ATI and nVidia) then loyalty and marketing make a huge difference.
Running your graphics card on multiple operating systems may interest you.
Going with a card company that supports AMD, OpenGL, Linux etc may be more beneficial to us all.
I always though nvidia bought 3DFXs technology and some of it shows today.
3DFX was great
A language that doesn't affect the way you think about programming is not worth knowing.


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Amazing unit on Doheny and Wilshire. Parking Available!
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Bomb-sniffing dog alerts positively to package outside D.C. courthouse
Associated Press Writer
WASHINGTON- A federal courthouse within sight of the Capitol building was evacuated Wednesday when a suspicious package was found. A police dog trained to detect explosives alerted positively to the package, officials said.
Sheldon Snook, chief of staff to Chief Judge Thomas Hogan, said fire alarms were sounded and the building was cleared as a precaution.
Law enforcement officials were surveying the area around the building's entrance where a police dog alerted to a scent picked up from the package, which was found near a construction trailer outside the courthouse entrance.
Evacuation of the E. Barrett Prettyman Federal Courthouse occurred shortly before a hearing was to begin in the CIA leak case.
Special prosecutor Patrick Fitzgerald and about eight of his associates were forced to leave the building and join more than 100 others on the sidewalks nearby.
The defendant in the case, former White House aide I. Lewis "Scooter" Libby, and his legal team had not arrived.
The judges of the U.S. District Court for the District of Columbia were moved across the street to the Superior Courthouse.
Copyright 2015 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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Bomb-sniffing dog alerts positively to package outside D.C. courthouse
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Econo Lodge Hacienda Motel Geelong
15 Mt. Pleasant Road
Geelong, VI 3216
Phone: (61) 3 52435844
Fax: (61) 3 52419613
- Free Internet
- Laundry, Guest
A Geelong Hotel - Econo Lodge Hacienda Motel Geelong near Geelong City Centre
The Econo Lodge® Hacienda Motel Geelong is conveniently located near many popular attractions. Local points of interest like the Geelong city centre, the Ford Discovery Museum, Maritime Museum and the National Wool Museum are minutes from this Geelong, Australia hotel.
Located along the banks of the Barwon River, Geelong is a port city boasting a number of bridges and picturesque views of the surrounding area. Visitors will find that this region of Victoria offers an array of activities ranging from sightseeing to exciting recreational activities like water skiing, boating, sailing and fishing. There are many wineries, local markets and restaurants close by.
Guests of this Geelong, Australia hotel can enjoy numerous features like an outdoor pool, afternoon tea, and access to copy and fax service.
The Econo Lodge Hacienda Motel Geelong offers a wide variety of accommodations range of accommodations, including double, family and two bedroom apartments. All guest rooms are air conditioned and are furnished with refrigerators, spacious work desks, hair dryers, irons, ironing boards and cable television.
For added convenience, this Australia hotel has on-site laundry facilities and valet cleaning service can be requested. Ample parking is provided and can accommodate most vehicles.
Whether you are traveling for business or pleasure, the Econo Lodge Hacienda Motel Geelong offers a relaxing atmosphere, friendly service and a convenient location. Make us your home away from home in Geelong and we'll make your stay memorable. Book a room with us today.
Features and Amenities
- Cable/Satellite TV
- Charge for Local Calls
- Flat Screen/Plasma TV
- Free Wireless High Speed Internet Access
- Hair Dryer
- In-Room Desk
- Individual A/C & Heat
- Iron & Ironing Board
- Non-Smoking Rooms Available
- Pay-Per-View Movies
- Refrigerator
- Room Service
- AM/FM Clock Radio
- Services/Amenities in Some Rooms:
- Microwave
- Wireless Internet


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Legislative News
Bipartisanship makes appearance
The Colorado Statesman
In the most bipartisan manner since the start of session, legislators Thursday announced a package of 10 bills on workforce development, ranging from internships to assistance with student loan payments and helping the unemployed find jobs.
More than two dozen legislators from both chambers and both sides of the aisle were on hand to announce the package; some bills are already in the process of moving through the legislature while others are not yet introduced.
Credit card bill watered down to study, then killed
The Colorado Statesman
An effort to provide relief to small businesses from fees they pay to banks for the authority to use credit cards has been watered down from "relief" to a study, but even as a study it turned into a big fight on Wednesday. In the end, members of the House Finance Committee voted the bill down on a 2-9 vote, citing concerns expressed by the agency that was likely to do the study as the reason to kill the bill.
As introduced, House Bill 15-1154 would ban credit card companies and banks from assessing the credit card fees to the state and/or local sales tax portion of a transaction.
'Hullabaloo' raised over Costilla GOP revival
The Colorado Statesman
Some Colorado Republicans are hopping mad over an organizational meeting that took place in the small town of Fort Garland last Sunday. Others, however, counter that it's much ado over simply following proper procedures.
The dispute centers around the Republican Party of Costilla County, an organization that didn't exist for most of the last year, in a sparsely populated expanse that rests on the state's southern border with New Mexico.
Former Rep. Amy Stephens joins McKenna Long & Aldridge
The Colorado Statesman
Former Republican House Majority Leader Amy Stephens is blazing a new trail in the private sector, joining the Denver office of McKenna Long and Aldridge LLP, an international law firm with 500 attorneys and public policy advisors in 15 offices and 13 markets.
Stephens was tapped by McKenna Long and Aldridge to lead the Colorado Government Affairs practice as the Denver office's newest managing director. Her engagement with the firm was formally announced in a press release Feb. 25 with a formal event hosted Tuesday night to welcome Stephens aboard.
Clinton's proven middle class vision
I served as Mayor of Denver from 1991 to 2003 and was the only mayor in U.S. history to serve as president of the U.S. Conference of Mayors, the National Conference of Democratic Mayors and the National Conference of Black Mayors. Through my experiences, I have seen Americans go through hard times, but I have also seen the power that strong economic policies that drive investment, create jobs, and bring hope to Americans can have on our communities.
Reasons Colo. should join lawsuit to hault Pres. Obama's unconstitutional 'executive amnesty'
Twenty-six states including 22 state Attorneys General and three governors have joined the Governor of Texas — that's 26 states in total — in suing the United States government to halt the Obama administration's 2014 "DAPA" amnesty program, which aims to award legal status and work permits to an estimated 4.4 million illegal immigrants.
Colorado should become the 27th state in that lawsuit, and you, the Attorney General, can do so at the stroke of a pen.
Borrowed cowboy hat better than no hat at all
The Colorado Statesman
During an interview with KUNC last week, new Commissioner of Agriculture Don Brown commented that he didn't own a cowboy hat.
During the Feb. 26 Governor's Forum on Ag, he got a chance to try on a new one, owned by his boss, Gov. John Hickenlooper. The governor took off his new Stetson, a gift from Sen. Larry Crowder, R-Alamosa, and dropped it on Brown's head.
JBC votes to dramatically reduce scholarship initiative
The Colorado Statesman
The Joint Budget Committee on Tuesday voted to dramatically scale back a request from the Governor for a state scholarship program that he mentioned in the 2015 State of the State address.
The JBC is in figure-setting this week for the 2015-16 budget. On Tuesday, the committee took up the budget for the Department of Higher Education. Gov. John Hickenlooper had asked for $30 million for the Colorado Opportunity Scholarship Initiative (COSI) for its second year of funding.
Sen. Owen Hill: Yoga master
State Sen. Owen Hill, R-Colorado Springs, demonstrates his yoga expertise with a particularly difficult position called "the crow". Hill struck the pose after a hearing last Wednesday on Senate Bill 186, which would exempt yoga teachers from the authority of the Division of Private Occupational Education.
Dem chair race heats up
The Colorado Statesman
Who will chart the course?
The three candidates for chair of the Colorado Democratic Party agreed that the state party needs to chart its own course distinct from Washington, D.C., at a forum on Sunday in Denver. But the candidates disagreed sharply over whether stunning losses in last year's election mean it's time for a change in party leadership or that experience counts more than ever as next year's presidential election looms.


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Aston Martin and Bang & Olufsen share a common approach. Both companies were founded by a pair of pioneering engineers at the start of the 20th century, and through a commitment to manufacturing skills and design values.
Together, Aston Martin and Bang & Olufsen present a partnership of two innovative companies with a proud tradition in technology and design. Both Aston Martin & Bang & Olufsen blend an unrelenting quest for technical excellence with an uncompromising commitment to quality and style, and both have the courage to go far beyond the conventional.
Bang & Olufsen BeoSound for Aston Martin has been developed exclusively for the Aston Martin models, acoustically and physically matched to the cars. While the visual aluminium elements match seamlessly with the dynamic lines and curves of the vehicles, the sound performance has been designed to the exact dimensions of the interior.
Through the use of pioneering acoustic competencies and proprietary technologies, Bang & Olufsen in conjunction with Aston Martin has managed to reach the highest possible level of seamless
integration, resulting in an incomparable ambience.
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