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Addiction Therapists in Des Moines
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Sovereign Health Alternative to Incarceration
Treatment Facility
"Sovereign Health offers court services and treatment programs for people who are dealing with legal issues such as a DUI, DWI, drunk in public, possession of a controlled substance, are among the list. If you or someone you know who has been charged with a crime and has substance abuse and/or mental health issues, there are many potential benefits for seeking help before going to trial. Additionally, if the crime is related to substance abuse problems or a mental health disorder, then treatment may be a required part of the journey through the legal system, such as court-ordered drug treatment or a court-ordered mental health evaluation. We invite you to visit us today and watch patient reviews of their hope and recovery at www.sovcal.com.
(866) 891-4199
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Sovereign Health Adolescent & Young Adult Programs
Treatment Facility
"High Quality and Comprehensive Adolescent Substance Abuse, Co-Occurring, Mental Health Treatment Programs Sovereign Health Adolescent Treatment Program is licensed by the Department of Social Services, Community Care Licensing. Our adolescent program provides evidence-based treatment modalities with a strong emphasis on intensive family therapy. Sovereign Health specializes in addressing the underlying mental health conditions by utilizing innovative and cutting edge cognitive testing, rehabilitation, and creating a long term support system and plan. We accept Most Private Insurances. Call today or visit our website to watch or read patient reviews about their treatment experiences at Sovereign Health Adolescent Treatment Program.
(866) 665-2567
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Sovereign Health Addiction & Dual Diagnosis
Treatment Facility
"Sovereign Health Group is a leading residential Addiction, Dual Diagnosis, and Mental Health residential treatment provider for adults and adolescents. We offer evidence based treatment, individualized treatment plans, cognitive testing and rehabilitation, individual and group therapy sessions, and many other treatment components We invite you to review our website, watch Sovereign Health Treatment reviews, chat online with us, or call for a free confidential assessment to learn more and discuss how Sovereign Health can be a solution for you. We ACCEPT MOST PPO insurance.
(866) 553-3730
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Jill Lehmann
Clinical Social Work/Therapist, LISW, ACSW, CADC
"You don't have to go at this alone. One of my mentors once told me if a person leaves with a little more hope and a feeling of possibility, I was doing my job. Getting better can be difficult but doing it by yourself makes it even more challenging. I have been providing clinical therapy services for 8 years and specialize in LGBT struggles, Veterans, addiction, depression, and anxiety. I embrace hope and the capacity for change in all people and believe being a partner in a change process is more important than anything else.
(515) 346-6811
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Melissa Cribari
Counselor, LMHC, CADC
"I provide individuals and families with therapy that is strength-based and family-oriented. I have worked with adolescents, adults and families helping them address relationship issues, substance use/dependency, anxiety, depression and stress and anger management. I work to help clients reach their goals by listening carefully to and understanding present problems. I help clients identify and explore problematic thoughts, feelings and behaviors that occur in their lives, understand how and why these patterns have developed, and discover how to make positive changes.
(515) 423-0934
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Jim Wilwerding
Counselor, MDiv, LMHC, CADC
"I know that the choice to begin counseling can often be a difficult one. Congratulations on taking the first step toward having the kind of life you want for yourself! I look forward to the opportunity to be of assistance to you on that journey. My areas of interest/specialty include all aspects of mental health counseling for adults, adolescents, and families in the areas of depression, anxiety, addictions, co-occuring disorders, codependency and spirituality. I draw upon diverse resources to approach the counseling process from the perspective of the strengths of the client and your place in life.
(515) 274-9690
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Connie S Remetch
Counselor, MA, LMHC, ACADC
"With 30+ YRS. PROFESSIONAL EXPERIENCE, I help adults, in a faith-supportive way, with: GRIEF & LOSS; DEPRESSION,ANXIETY, & STRESS; ALCOHOL/DRUG CONCERNS; EATING DISORDERS & WEIGHT MANAGEMENT; RELATIONSHIPS including ABUSE & TRAUMA; WEIGHT LOSS SURGERY.
(515) 635-5985
Office is near:Des Moines, Iowa 50314
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Penny Nichols-Peterson
Clinical Social Work/Therapist, LISW
"I believe in the process of therapy and I am dedicated to helping you reach your goals. If you are seeking assistance and would like to begin therapy with a down-to-earth and compassionate therapist, I may be the right match for you. I believe you have the answers within you and any changes you make are the result of your hard work. If you choose to share your story with me, I will feel honored to help guide conversations, offer a different point of view, challenge thoughts, and listen with a non-judgmental mind and open heart.
(515) 619-5257
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Laurie Fein
Clinical Social Work/Therapist, MSW, LISW, CADC
"Do you need someone to talk to? Are you struggling with your family, your marriage or another relationship? Are you dealing with a dilemma, worries, your goals, your identity, major changes or just life? I offer confidential mental health counseling for individuals, couples and families in a private home built in 1857 and surrounded by forest. While I specialize in anxiety, depression, trauma, adhd, relationships and substance abuse, my primary specialty is you and concerns that you bring with you to the session. I strive to be "here for you, not the other way around." Naturally, diversity is celebrated here.
(515) 200-1523
Office is near:Des Moines, Iowa 50309
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Ashley Stavig
Clinical Social Work/Therapist, MA, LMHC
"Ashley is a Licensed Mental Health Counselor who utilizes a range of modalities to help address areas of concern including, but not limited to, depression, anxiety and trauma. Ashley believes therapy is a process in which the therapist and client collaborate to create positive change. Her professional training includes working with adults with co-occurring disorders as well as working with children conducting school-based mental health. Her experiences have taught her to effectively work with children, adolescents, and adults. Therapy is a time to address underlying issues so you can reach your goals and enjoy life!
(515) 512-4306
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Susin Bredice
Clinical Social Work/Therapist, LMSW
"Making the decision to start therapy can be a very vulnerable time, whether it be for you or your child. In therapy you will have a safe and judgement free space to meet your goals. I enjoy working with children and adults to recognize strengths and build on them to assist you in meeting your well being needs. Whether you are struggling to overcome an incident or event, wanting to make specific changes in you life, or looking to improve your overall quality of life and feel better about yourself, we will work together.
(515) 512-4658
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Ronda L Hood
Counselor, IADC, LMHC
"Are you burdened with constant worry, anxiety, depression or sadness? Life does not have to feel or be so hard. Do you need to make changes in your life and need help in making those changes? Do you keep running into barriers and realize that you're the one putting up those barriers? I can help you make the changes that you desire! My specialties are working with individuals with Anxiety, Depression, Addictions &/or Dual Disorders.
(515) 608-8034
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"LSI (Lutheran Services in Iowa) provides a range of therapy and counseling services to help families address social, emotional and behavioral issues. Services are available for young children, teens, adults and veterans. Our therapists may help if you are going through a divorce, having relationship problems or experiencing depression, anxiety or other mental health needs. We can also help parents improve family dynamics and solve conflicts with their children. We provide behavioral health intervention services and therapy for teens who are aggressive, delinquent, depressed or having trouble at home or school. We listen, we understand, and most importantly, we care.
(866) 840-5053
Des Moines, Iowa 50311
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Susan Honor Haines
Clinical Social Work/Therapist, LMHC, CADC, MS
"I understand that looking for a therapist can sometimes be challenging. When its hard to know where to turn know that I will bring to your session not only 20 years experience, but a focus on developing a client-focused environment where together we can work toward the change you are seeking - for yourself, your family and/or your relationship.
(515) 393-2570
Des Moines, Iowa 50322
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Amanda Bocock
Marriage & Family Therapist, MA, t-LMFT
"I see clients as a people first, problems last. Everyone experiences difficulties and stressors in life. Sometimes families need an unbiased and supportive approach that infuses new energy into making change. I look to provide a direct yet relaxed approach to serving my clients. I possess a strong belief that working with multiple people in a client's life creates a greater level of lasting change due to the shared experiences and the understanding a family gains when working together.
(515) 512-4337
Verified by Psychology Today
Amanda Burgod
Clinical Social Work/Therapist, LMSW
"Going to therapy can be a difficult experience and it is my goal to ensure that everyone is treated with respect in a safe and judgement free environment. I enjoy working with teenagers and adults who want to improve their circumstances and emotional well- being even if they are unsure how to do this. I believe that everyone has strengths they bring to the table and my goal is to help my clients recognize the strengths within themselves as assets to achieving their goals.
(515) 212-2614
Verified by Psychology Today
Lars Peterson
Clinical Social Work/Therapist, LMSW
"When working with individuals, couples, or families my approach is supportive and practical. This approach is grounded in listening deeply to understand each unique situation and then tailoring my approach to match the situation and client goals. Before becoming a therapist I worked as a manager and business consultant, mediated family and community disputes, and worked with high risk youth in a diversion program. While still in graduate school I also facilitated mindfulness-based stress reduction classes.
(515) 512-5009
Verified by Psychology Today
Thomas Sunderman
Counselor, MA, LMHC
"I believe it is important to meet you as an individual, couple or family where you are at in your unique journey in life. During this process, I feel it's essential for you to encounter a non-judgmental, accepting and empathetic atmosphere through which you can work on areas of your life at a pace you feel comfortable with. Additionally, it is my hope that you experience a sense of empowerment and motivation to grow and move towards self-discovery.
(515) 393-4143 x6
Verified by Psychology Today
Edgar Villarreal
Psychologist, PhD
"Are parts of your life weighing you down? Do you sometimes feel powerless against your thoughts, behaviors, and emotions? Have events in your life left you searching for answers and yearning for peace? As your psychologist I will help you explore your concerns and regain a sense of balance and control over your life. Together we will develop an understanding of these issues and implement a plan to address them. You will gain insight and the necessary skills to tackle both current and future challenges. Lets work together to make meaningful change so you can live a more fulfilling life.
(515) 207-2646
Des Moines, Iowa 50305
Verified by Psychology Today
Donald M. Kaesser
Psychologist, PhD, PC
"My goals are to use 25 years of direct clinical experience to help in addressing issues that have become obstacles in your life and to help you meet your goals in the context of an honest, caring and direct professional relationship. Individual therapy, couples/relationship issues, substance abuse issues, depression, anxiety, grief, aging, sexuality and sexual 'orientation' issues, as well as family matters are among the range of aspects of people's lives on which I effectively work. Counseling may be brief and problem-oriented, or involve an extended therapy depending on your needs. I enjoy individuals, couples and seniors.
(515) 981-6980
Not enough Addiction Therapists to choose from?
Try expanding your search for Therapists in Des Moines to a larger area (e.g. Polk County, Iowa)
Addiction Therapists
If you're looking for help with an addiction in Des Moines or for a Des Moines addiction counseling these professionals provide addiction therapy (or addiction therapies) and addiction treatment in Des Moines. Addictions are deceptive: they begin small and then take a hold so that behaviors as common as smoking addiction, or quitting smoking, may become challenging to change. Professional help can be vital. These professionals include addiction Therapists, addiction psychologists and addiction counselors in Des Moines. They can help addicts with alcohol addiction, drug addictions, and less understood addictions like gambling addiction, internet addiction and sex addiction.
For substance abuse, the professionals have experience helping individuals with cocaine addiction, marijuana addiction, methamphetamines ('meths' addiction), opiate addiction and heroine addiction. They provide Des Moines addiction counseling, addiction intervention, addiction support, referrals in Des Moines, detox, rehab and Des Moines 12 step programs.
How can I tell if a therapist is right for me?
Therapists in Des Moines have broad skills and are able to work with a wide range of issues.
For example, if you're seeking a marriage counselor in Des Moines you'll find that most therapists are trained in marriage counseling or couples counseling in Des Moines and couples therapy. And they welcome families for family counseling in Des Moines or family therapy in Des Moines.


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Page 1
Mast cell activation by fibrinogen-related homologous
c-terminal peptides (haptides) modulates systemic blood
Maamoun Basheer, MSc,aHerzl Schwalb, PhD,bMaoz Nesher, MSc,cDan Gilon, MD,dIrit Shefler, PhD,f
Yoseph A. Mekori, MD,fOz M. Shapira, MD,b,eand Raphael Gorodetsky, PhDa
Jerusalem and Kfar Saba, Israel
Background: Haptides are a family of short peptides
homologous to C-termini sequences of fibrinogen chains b and g
(haptides Cb and preCg, respectively) which were previously
shown to penetrate and bind cells.
Objectives: This work investigates the systemic effect of the
haptides with possible clinical implications.
Methods: Intra-arterial monitoring in rats recorded the
haptides' effects on systemic blood pressure. In parallel, their
effect was also tested in vitro on isolated rat peritoneal mast cells
and on human mast cells.
Results: Intra-arterial monitoring in rats showed that
intravenous administration of low haptides concentrations
(35-560 mg/kg rat) caused a shocklike behavior with transient
decrease in the systolic and diastolic blood pressure by up to
55% (P < .05) in a dose-dependent manner and a minor
increase in their heart rate. Randomly scrambled sequences of
the haptides had no such effect, suggesting a specific
interaction with receptors. Intravenous administration of
blockers to histamine receptors H1 and H2 before haptides
administration attenuated this effect. Furthermore, in vitro
incubation of human LAD2 mast cell line or isolated rat
peritoneal mast cells with the haptides caused degranulation of
the mast cells. We found that the haptides Cb and preCg
activated mast cells causing histamine release, resulting in a
steep decrease in blood pressure, comparable to anaphylactic
Conclusion: In treating vascular occlusive diseases, massive
fibrinolysis is induced, and haptide-containing sequences are
released. We suggest that treatment with histamine receptor
blockers or with mast cell stabilizing agents in such pathological
conditions may overcome this effect. (J Allergy Clin Immunol
Key words: Haptides, fibrin, mast cells, hypotension, histamine,
Fibrinogen molecules and fibrin gels were found to be highly
cell-binding.1Part of the mediation of cell binding was recently
attributed to small conserved family of short homologous
(;20mer) sequences on the c-termini of b chain and just preced-
ing the c-termini of the g chain (Cb and preCg, respectively).2
Another partially homologous sequence is present on the ex-
tended a-chain aE, which is seen only in small fraction of fibrin-
ogen molecules in adult mammals because of posttranslational
modification.2-4We termed this family of homologous peptides
haptides because of their haptotactic (cell-binding) properties.
Haptides also showed high penetration properties into cultured
cells,2,5probably mediated by their structure and their relatively
It is of major interest that all the haptides in a wide range of con-
centrations tested had no apparent cytotoxic effect invitro on dif-
ferent cell types, including normal fibroblasts and endothelial
cells.2When bound to collagen matrix implants in rats, haptides
increased cell binding with no adverse effects.6Haptides' effect
was also tested ex vivo on isolated perfused beating hearts, in
which high levels of haptides caused significant vasoconstriction
of the coronaries, resulting in impaired heart functions.7
Nevertheless, the systemic effect of the haptides has not been
investigated previously.
The possible effect of haptides administered into the circula-
tion is highly relevant to clinical practice. Fibrinolysis is a
prominent treatment for salvaging ischemic organs caused by
obstructive thrombotic events, resulting in a release of peptides
containing haptidic sequences.8,9The effectiveness in reducing
morbidity in acute myocardial infarction is dependent on early
thrombolytic therapy.10-12Streptokinase is widely used to initiate
this cascade by inducing the activation of the fibrinolytic enzyme
plasmin, which degrades fibrin clots at specific sites, yielding
identifiable soluble fragments that are released to the circula-
circulating fragments, was observed in numerous pathological
conditions14-17and could serve as a marker of many vascular
Low-molecular-weight fibrinogen degradation products derived
fibrin degradation products mediate platelet activation,19,20fibro-
blast proliferation,21endothelial cells spreading, proliferation and
capillary tube formation,20and promotion of angiogenesis.22,23
The current study examines whether haptides can contribute to
the systemic side effects that are observed after massive fibrinol-
ysis. Our findings in the current report suggest that haptides
exhibit hemodynamic effects with significant induction of
Cardiothoracic Surgery, and the Departments ofcPhysiology,dCardiology, and
eCardiothoracic Surgery, Hadassah-Hebrew University Medical Center, Jerusa-
lem; and
Center, Kfar Saba.
ited P/S, New Orleans, La (Joseph Lunenfeld Cardiac Surgery Center).
Disclosure of potential conflict of interest: The authors have declared that they have no
conflict of interest.
Received for publication December 14, 2009; revised July 18, 2010; accepted for publi-
cation July 21, 2010.
Available online September 15, 2010.
Reprint requests: Raphael Gorodetsky, PhD, Head, Biotechnology and Radiobiology
Laboratory, Sharett Institute of Oncology Hadassah-Hebrew University Medical
Center, POB 12000, Jerusalem 91120, Israel. E-mail: email@example.com.
? 2010 American Academy of Allergy, Asthma & Immunology
athe Laboratory of Biotechnology and Radiobiology, Sharett Institute of
bthe Cardiothoracic and Thoracic Research Center, Department of
fthe Laboratory of Allergy and Clinical Immunology, Meir Medical
Page 2
Abbreviations used
BP: Blood pressure
Cb: Haptides, homologous to sequences on the
C-termini of fibrinogen beta chains
DBP: Diastolic blood pressure
b-hex: b-Hexosaminidase
HR: Heart rate
LAD2: Human mast cell line
MAP: Mean arterial pressure
preCg: Haptides, homologous to sequences on the
C-termini of gamma chains
SBP: Systolic blood pressure
hypotension. Furthermore, we propose that the mechanism of
such effect may be associated with histamine and serotonin
secretion as a result of systemic activation of mast cells.
Peptides synthesis
(KTRWYSMKKTTMKIIPFNRL) correspond to addresses 471-491 of the C-
the g chain, respectively. The control peptide Ca (SEADHEGTHSTKR-
GHAKSRP) corresponds to a sequence close to the C-terminal of fibrinogen
a chain. The arbitrary scrambled sequences of Cb and preCg were
ISSWYKFPMQGQKRPRMSFKM and FIKLMNPWSTRYIKMRTKTK, re-
spectively. The peptides were synthesized by GeneScript (Piscataway, NJ).
The experiments used peptides that were >90% pure as determined by HPLC
and mass spectrometry.
Human fibrinogen as a component of a tissue sealant was obtained
nadine, famotidine, pyrilamine, cimetidine, cromolyn A, and p-nitrophenyl-
N-acetyl-b-D-glucosaminide were supplied by Sigma (Rehovot, Israel).
Male Sprague-Dawley rats (275-300 g; Harlan Laboratories, Rehovot,
Israel) were grown in specific pathogen-free conditions. All animals received
Animals (http://www.nap.edu/catalog/5140.html). The experiments were ap-
proved by the Institutional Animal Care and Utilization Committee.
Blood pressure monitoring
Male Sprague-Dawley rats (250-300 g; Harlan Laboratories) were kept in
specific pathogen-free conditions in accordance with the Guide for the Care
and Use of Laboratory Animals (NIH pub no. 86-23, revised 1996). Experi-
ments were approved by the Institutional Animal Care and Utilization Com-
mittee (Application MD-103.05-1).
on a heated pad. Rectal temperature was adjusted to 37.5 to 388C by a rectal
probe. After tracheotomy and insertion of a PE260 catheter, the right femoral
artery and vein were cannulated with a PE50 heparinized tube. Blood pressure
ducer (MEMSCAP, Skoppum, Norway) coupled to an amplifier (Laboratory
in parallel. Mean arterial blood pressure (MAP) was calculated as the sum of
two thirds diastolic blood pressure and one third systolic pressure (mmHg).
After 20 minutes of equilibration, peptides dissolved in saline were
administered by a bolus injection through the femoral vein cannula in a final
minutes, a higher dose of the peptide was injected, and the hemodynamic
parameters were measured for additional 15 minutes. The maximal effect of
the haptides was recorded after 3 minutes.
In the histaminergic blockade experiment, rats were intravenously admin-
istrated with the histamine antagonists cimetidine (15 mg/kg) and pyrilamine
haptide injection. Cromolyn A (intravenous, 1 mg/kg/min) was injected for 5
minutes before haptide injection. Administration of the saline and antagonist
H1 and H2 alone had no significant effect on the BP.
Isolation and purification of rat peritoneal mast
Rat peritoneal mast cells were obtained from Sprague-Dawley rats by a
peritoneal lavage, and the cells were purified as previously described.24
Briefly, a suspension of washed peritoneal cells was layered over a cushion
of 30% Ficoll 400 (Pharmacia Biotech, Uppsala, Sweden) in buffered saline
supplemented with 0.1% BSA and centrifuged at 1500g for 15 minutes. The
by toluidine blue staining.
Purified mast cells (5 3 105cells/mL in a final volume of 0.5 mL) were in-
cubated in Tyrode buffer (137 mM NaCl, 2.7 mM KCl, 20 mM HEPES, pH
7.4, 1 mM CaCl2, 5.6 mM glucose, 1 mg/mL BSA) and were stimulated by
the activating agent for 20 minutes. Reactions were terminated by placing
the tubes on ice, followed by a brief centrifugation by microfuge (12,000
rpm for 20 seconds) at 48C. Aliquots of 50 mL were collected from the super-
natant for determination of histamine levels.
The amount of histamine released was determined by using the O-phthal-
dialdehyde fluorometric method, as previously described.24,25The results are
presented as final concentration of histamine above the baseline values.
Histamine released after haptides administration
Blood samples were collected after intravenous administration of haptides
(preCg or Cb) or the control peptide Ca at a concentration of 280 mg/kg
animal. The blood samples were centrifuged for 10 minutes at 3000 rpm.
Aliquots of 50 mL plasma were used for the determination of histamine, as
previously described.24,25Results are presented as net concentration of hista-
mine released. The baseline histamine and negligible readings of haptides
alone in the system were deducted from the relevant readings.
Human-derived LAD2 mast cells line
The LAD2 human mast cell line was maintained and used as previously
described.26The LAD2 human mast cells (106/mL) were incubated with the
Cb and preCg haptides. A dose response for both haptides activity was per-
formed for 2 minutes incubation for doses of 0.1 to 100 mg/mL. Incubation
with the peptides Cb or preCg as well as with the control Ca at concentration
of 50 or 100 mg/mL. Mast cell degranulation was measured by b-hexosamin-
idase (b-hex) release as previously described.27,28Briefly, 20 mL sample
supernatants were mixed with 50 mL substrate solution (8 mmol/L p-nitro-
phenyl-N-acetyl-b-D-glucosaminide in 48 mmol/L citric acid and 56 mmol/
L Na2HPO4,pH 4.5), and incubated for 90 minutes at 378C. The reaction
was stopped by addition of 150 mL ice-cold glycine (0.2 mol/L, pH 10.7),
and the optical density measurement was immediately performed by using a
spectrophotometer (OD 405 nm). Results were expressed as percentage of to-
tal b-hex activity present in the cells as previously described.26,29Total activ-
ity was the one measured in cell lysates plus supernatant. Haptides alone had
no effect on the readings. For IgE-mediated activation, cells were sensitized
overnight with 100 ng/mL human myeloma IgE-biotin (Calbiochem, Merck
KGaA, Darmstadt, Germany), then stimulated with 100 ng/mL streptavidin
(Jackson ImmunoResearch Laboratories, West Grove, Pa) as previously
Statistical analysis
All values are expressed as means 6 SEs. One-way ANOVA and a 2-tailed
Student t test were used for comparing between relevant groups. Statistical
differences of P <.05 were considered significant.
Page 3
Effect of haptides on the rat hemodynamic
Intravenous injection of a 1.5 mg/kg bolus of both fibrin-related
the animals with a shocklike behavior. In sedated rats, intravenous
administration through the femoral vein resulted in significant
reduction of blood pressure as monitored by intra-arterial monitor
(Fig 1). The maximal effect was observed within 3 minutes after
pulse administration of the haptides. Full recovery was recorded
effect on arterial blood pressure, made up of an initial intense but
that persisted until the full recovery in about 15 minutes (Fig 1, A).
The administration of haptides (preCg and Cb) within the
concentration range of 35 to 560 mg/kg produced a dose-
dependent decrease of the systolic BP (SBP), diastolic BP
(DBP), and MAP (Fig 1, B-D). Maximal MAP decrease of as
much as 50% (P < .01) was recorded at a higher dose of
280 mg/kg (Fig 1, D). In addition, the HR minimally increased
in correlation with doses of haptides given, reaching a significant
elevation at 560 mg/mL (P <.05; Fig 1, E). However, the control
peptide Ca at the same concentration did not affect both BP and
HR (Fig 1, B-E).
Effect of scrambled haptides sequences and whole
fibrinogen on rat blood pressure
To study the specific effect of haptides sequences that
modulate BP, scrambled sequences of haptides were tested. In
parallel, the effect of the whole intact fibrinogen molecule was
also studied. Administration of 280 mg/kg scrambled sequences
of the haptides, preCg and Cb, or fibrinogen did not affect the
FIG 1. Effect of escalating doses of intravenous (IV) administration of haptides on blood-pressure and heart
rate in the rat. A, An arterial pressure records at baseline and 6 minutes after intravenous injection of 1.5 mg/
kg Cb showing a triphasic response effect on blood pressure (lines 1-3). Haptides effect (35-560 mg/kg) on
diastolic, systolic, and mean arterial BP as well as heart rate were tested (n 5 6) (B-E, respectively). Results
were compared with the control peptide Ca (*P < .05; **P < .01).
FIG 2. Effect of haptides versus scrambled haptides sequences on DBP,
SBP, and MAP.Rats were injected with 280 mg/kg of the haptides Cb, preCg
or their scrambled versions as well as with whole human fibrinogen (n 5 6).
The results (mean 6 SE) are presented as percentages of the baseline
values. The effects are compared with the baseline values (P < .01).
Page 4
SBP, DBP, MAP, or HR (Fig 2). In contrast, haptides preCg and
Cb at a concentration of 280 mg/kg decreased SBP, DBP, and
MAP by 50% of baseline blood pressure values (P < .01).
Effect of the mast cell secretagogue compound 48/
80 and serotonin on BP
The reduction of BP by haptides is similar to the effect
observed after repeated injections of the mast cell secretagogue
compound 48/80 (Fig 3, A). This suggests that haptides-mediated
hypotension could be generated by mast cell activation and hista-
mine release.
Intravenous bolus injection of compound 48/80 (35-280 mg/
kg) in rats resulted in a dose-dependent decrease in SBP, DBP,
and MAP (Fig 3, B). Serotonin injection in a range of 3 to
30 mg/kg also resulted in a dose-dependent decrease in the
BP (Fig 3, C).
Histaminergic blockade attenuates haptide
hypotension effect
To verify that haptides-induced hypotension is associated with
mast cell activation, the rats were pretreated with histamine
rats with cimetidine, a histamine receptor type 2 antagonist, and
pyrilamine, a histamine receptor type 1 antagonist (Fig 4, A),
resulted in a significant attenuation of haptides-induced decrease
of the BP (P < .05). Infusion of the mast cell stabilizing agent
cromolyn A 5 minutes before haptide injection hindered the
haptide-mediated hypotension effect (Fig 4, A). The effect was
most pronounced for preCg (P <.05). Cromolyn alone did not af-
fect any of the parameters tested. An example of a chart of the re-
corded BP drop caused by intravenous administration of haptide
and modulation with pretreatment with cromolyn is presented in
Fig 4, B. The red arrows indicate the amplitude and time interval
FIG 3. Compound 48/80–mast cell activator and serotonin decreases rat BP in the same manner as haptides.
A, Trace record of arterial pressure at baseline and following intravenous (IV) injection in rat of 2 mg/kg
compound 48/80. Hemodynamic parameters in response to escalating doses of compound 48/80 and sero-
tonin are summarized in B and C, respectively (n 5 6). Results presented as percentages of the baseline
(mean 6 SE). The effects are compared with the baseline values (*P < .05; **P < .01).
FIG 4. Histaminergic blockade attenuates haptides' effect on rat blood pressure. A, Effect of haptides (280
mg/kg) on hemodynamic parameters in rats pretreated with cromolyn or with pyrilamine and cimetidine. B,
A chart of blood pressure drop caused by intravenous haptide administration and pretreatment with cromo-
lyn. C, Effects of haptides on BP in rats pretreated with fexofenadine or famotidine. The results (mean 6 SE)
are presented as percentages of the baseline (n 5 6; *P < .05).
Page 5
The samearrowsaresuperimposedontheresponserecorded with
of the reduction of the haptide effect. The newly introduced
antihistamine agent fexofenadine showed a significant inhibition
(P <.05) of haptides-induced decrease of BP (Fig 4, C). These re-
sults clearly demonstrate that mast cell stabilizers and histamine
antagonists significantly attenuated the haptides-induced hypo-
tensive response. This further indicates that the systemic effect
of the haptides, as reflected by a drop of BP, seems to be associ-
ated with regulation of histamine secretion by mast cells.
Haptides activate rat peritoneal mast cells
mast cells was tested. Thus, peritoneal mast cells were incubated
in the absence or presence of haptides (100 mg/mL), and
histamine content was measured in the supernatant. Trypan blue
exclusion assay showed that the haptides had no effect on cell
viability, which was found to be greater than 98% in all
Incubation of rat peritoneal mast cells with haptides, preCg,
and Cb for 30 minutes resulted in a significant histamine release
(Fig 5, A) relative to the group that was treated with the Ca inac-
tive control peptide (P <.05). Furthermore, intravenous haptides
administration induced a significant increase in plasma histamine
level (Fig 5, B) relative to the control group (P <.05).
Haptides activate cultured human mast cells
tested by b-hex release. A dose response of the haptides' effect
after 2 minutes of exposure is shown in Fig 6, A. The effect was
tested after incubation for 2 or 30 minutes in the presence of 2
doses of the haptides (50 and 100 mg/mL), as seen in Fig 6, B
and C. In both concentrations, the haptides induced a highly sig-
nificant b-hex release (Fig 6, B and C; P <.05) not dependent on
the time of incubation. In the same conditions and experimental
system, activation of the LAD2 human mast cells for 2 and 30
minutes via the FceRI (biotinylated IgE plus streptavidin)
resulted in only 5% and 15% b-hex release, respectively (data
not shown). The effect of the haptides on b-hex release was
also evident within the very short time of 2 minutes after the ad-
dition of the haptides, which coincides with the time scale of the
systemic effect by in vivo administration. The control unrelated
peptide Ca had no such effect (Fig 6, B and C).
Effect of serotonin receptor antagonist on the
vasopressor phase mediated by haptides
Both the injection of serotonin and high-dose haptides induced
a triphasic effect on arterial BP made up of an initial intense but
brief vasodepressor response followed by a moderatevasopressor
response (Fig 1, A). Finally, a longer-lasting vasodepressor re-
sponsewas recorded. Thevasopressor phasevaried quantitatively
depending on the species and the experimental conditions.31-34
by ketanserin, a serotonin receptor type 2 (5-HT2) antagonist
(Fig 7, A-D).
We have previously identified and characterized the haptides, a
family of cell-binding and penetrating fibrin-related peptides.2,5
The importance of the current study is in demonstrating that the
venous administration of relatively low doses (35-560 mg/kg) of
haptides Cb and preCg induced significant hypotension (Fig 1).
injection of the haptides. Higher doses of haptides (1.5 mg/rat)
resulted in triphasic effect on the arterial BP,made up of an initial
intense brief vasodepressor response followed by a moderate
vasopressor response. Later, a longer-lasting vasodepressor re-
occlusive arterial diseases, where vast amounts of fragments of
fibrin withhaptides sequences arereleased intothe circulation.8,9
result of the activation of mast cells, followed by histamine and
serotonin release, as observed during anaphylaxis.31This is fur-
ther supported by the direct evidence whereby intravenous hapti-
des injection indeed caused a significant histamine release (Fig 5,
A). Asimilar effect on BP was also observed, with similar timing,
after the injections of compound 48/80 (Fig 3), a known mast cell
secretagogue, or serotonin, an active mediator and histamine an-
alog in rats that is stored in mast cell granules.32-34In parallel, the
effect of haptides on blood pressure was suppressed by histamine
receptor type 1 and 2 antagonists or cromolyn A, a mast cell–
significantly suppressed the effect of haptides on blood pressure
more than famotidine. Although famotidine is a histamine
H2-receptor antagonist that inhibits H-pump and is used in the
treatment of peptic ulcer disease and gastroesophageal reflux,35
it is only marginally involved in regulating blood pressure
compared with histamine H1 receptors that are blocked more ef-
ficiently by fexofenadine.36Therefore, it is not surprising that fa-
motidine did not mask the effect of haptides as much as recorded
with fexofenadine.
The time interval of haptides-induced in vivo maximal effect
was short, within ;3 minutes after their administration. To
FIG 5. Haptides activate rat mast cells. Effect of haptides on histamine
release in isolated rat peritoneal mast cells. The mast cells (2 3105cells/mL)
were preincubated for 30 minutes with 100 mg/mL haptides (A). Plasma his-
tamine level in rats pretreated with 280 mg/kg preCg, Cb, or the control (Ca;
n 5 5; B). Results are presented as means 6 SEs. The effects are compared
with the control peptide Ca values (*P < .01).
Page 6
investigate whether this timing is sufficient for an induced effect
caused by mast cells activation, we tested the timing for a direct
effect of haptides on cultured mast cells. Both haptides preCg
and Cb induced significant degranulation of the LAD2 cells
(Fig 6) within a short time of 2 minutes. This indeed conforms
to the timing of the onset of the effect observed in the whole an-
imal (Fig 1).
The vasopressor response to serotonin can be blocked by
5-HT2 receptor antagonists such as ketanserin.37,38Accordingly,
are generally mediated by 5-HT2 receptors.33,37-39We found that
the vasopressor response to haptides was blocked by 5-HT2
receptor antagonist ketanserin (Fig 7), indicating that haptides
affect on cardiovascular function is associated with activation
of the serotonin receptors.
It is expected that in treating certain pathological conditions
such as occlusive blood vessels disease, massive degradation of
fibrin and fibrinogen is induced. In such conditions, peptides
FIG 7. Effect of intravenous administration of ketanserin, 5-HT2 receptor antagonists, on BP variability in
rats. Trace records of arterial BP at baseline and 6 minutes after injection into the femoral veins of 2 mg/kg
haptides Cb (A) or preCg (C). Tracings of arterial BP records where both haptides were injected 10 minutes
after a singledose of intravenous ketanserin (1mg/kg) administrationare presented in B and D, respectively.
FIG 6. Effect of haptides on degranulation of cultured LAD2 cells. Haptides effects on LAD2 cells activation
as monitored by b-hex secretion. A, Dose response of 2-minute incubation with haptides. The cells were
preincubated for 2 minutes (B) or 30minutes (C) with 50 or 100mg/mLwith haptides preCg,Cb, or the control
Ca (n 5 4). Values are percentages of total b-hex release. The haptides effects are presented relative to Ca
Page 7
containing haptides sequences are released into the circulation.
Each fibrinogen molecule contains 4 haptidic sequences.8,9In
cases with massive fibrinolysis, fibrin degradation products with
haptide containing sequences are equivalent to haptides levels
of ;1 to 5 mg/mL.40,41In our rat model, the effective levels of
haptides in the circulation that influenced BP were in the range
of 0.5 to 7 mg/mL. In the in vitro system with LAD2 cells
(Fig 6, A), the potent concentrations tested (<10 mg/mL) were
equivalent to those used in vivo (;0.5-7 mg/mL blood or
perimental rat model seem to be equivalent to the physiological
situation in cases associated with massive fibrinolysis.
It was previously demonstrated that low-molecular-weight
fibrinogen degradationproducts causeddose-dependentsecretion
of collagenase and histamine from mast cells.42Our study iden-
tifies the haptides as potential fibrin-related sequences that could
trigger such effects after fibrinolysis.
The damage to blood vessels caused by clot formation induced
endothelial-mediated mast cell attraction. The activated mast
cells were previously shown to release b-tryptase, a specific
enzyme of mast cells.43Tryptase, a very potent proteolytic en-
zyme, was shown further to enhance full degradation of fibrin,
as well as fibrinogen, to produce fibrinopeptides of smaller size
containing haptides sequences.44This positive feedback cycle
may increase the haptides release, which may further activate
the mast cells that in turn secrete more tryptase.
Therapeutic use of plasminogen activators remains controver-
sial because of the sometimes inefficient restoration of blood
Streptokinase-based treatment was found to be associated with a
risk of developing hypotension.12,45The mechanism responsible
for this streptokinase effect remains unknown.18,46,47We suggest
results in the release of smaller fragments containing the C-ter-
mini of fibrin with haptide sequences,8,9which, as shown here,
may trigger hypotension.
It is of interest whether the specific haptides effect may be
mediated by a receptor. The control peptide Ca, which is not re-
lated to the haptides, did not affect the BP (Fig 1). Even arbitrary
scrambled sequences of the haptides that have similar mean
hydrophobicity and positive charge had no such effect (Fig 2).
Furthermore, we found that haptides caused major mast cell acti-
vation in a system without IgE and added complement (Fig 6),
whereas IgE and the specific antigen caused merely 15% activa-
tion at 30 minutes.29These findings suggest that the haptides ef-
fect is probably not equivalent to classical IgE mediated
activation. Their major effect may be mediated through a specific
receptor on the target cells that has not been identified yet.
Nevertheless, a direct effect, such as the one recorded by basic
secretagogues that were previously proposed as effectors of ana-
phylaxis, still cannot be ruled out.29,48
Integrin aIIbb3 is highly expressed in mouse, rat, and human
mast cells. In the presence of stem cell factor and FceRI, it was
reported to bind to fibrinogen and activate the mast cells.49We
found that the haptides alone, but not the whole fibrinogen, with
no addition of other factors, induced mast cells activation. There-
fore, other candidate targets may also be considered.
To conclude, haptides were shown to induce release of hista-
mine and serotonin from mast cells, which can explain their me-
diation of hypotension. This response can be abrogated by
histamine receptor antagonists and other anti-inflammatory
drugs. These findings may be relevant to the possible mode of ac-
tion of circulating fibrinogen fragments containing haptides as a
result of induced fibrinolysis in the management of vascular oc-
clusive diseases.
We thank Prof Levi-Schaffer (Department of Pharmacology and Experi-
mental Therapeutics, School of Pharmacy, Faculty of Medicine, Hebrew
University of Jerusalem) for her assistance in assessing rat-derived mast cells
and Esther Houminer (Cardiac Surgery Research Center, Hadassah-Hebrew
Levdansky and Elena Gaberman for their general laboratory help on this
Clinical implications: Haptides, short peptides homologous to
sequences on the C-termini of fibrinogen, induce hypotension
by mast cell activation; thus, they are presented as possible
key mediators of hypotension after streptokinase-induced
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text:
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View Full Article in:Press of Atlantic City (N.J.), The
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These days, apps are ubiquitous as tools to improve health and fitness. But Apple thinks it can do more than that and even take medical research to a new level, thanks to its power to crowdsource subjects in clinical tests and monitoring studies. Can the company's recently-announced ResearchKit, an open source software framework for researchers, be the medical study game changer that it's aiming to be? Read More
Elon Musk's Hyperloop takes a step closer to reality
It seemed like a pipe dream when floated in 2013 by Tesla and SpaceX founder/CEO Elon Musk, but the Hyperloop concept is making tangible progress, though it is still a long way off taking passengers. A startup company called Hyperloop Technologies has been established, with US$8.5 million raised and another $80 million in funds projected for later this year. Meanwhile, another startup called Hyperloop Transportation Technologies (HTT), formed in 2013, has crowdfunded and crowdsourced its way to a team of 170 mostly part-time engineers and designers. Read More
Handground coffee grinder lets you choose how fine you grind
For coffee enthusiasts, preparing a brew can be as important as what beans are being used. Gizmag has covered lots of coffee makers over the years, but how the beans are ground also makes a difference. The Handground coffee grinder promises a consistent and precision grind for a better flavor. Read More
A new crowdsourcing initiative is calling upon the public to help catalog the ever increasing library of images snapped of our planet, and more importantly its cities, at night from the International Space Station (ISS). With your help, the Cities at Night project could help map light pollution spanning the course of the 16 year period in which the images where taken, with the added bonus of giving volunteers the opportunity to flick through a catalog of stunning images that highlight the mark we make on our planet at night. Read More
Local Motors unveils crowdsourced sports car
Local Motors recently ran a design challenge for an exploratory sports car. The challenge asked participants to focus on aesthetics, performance, affordability and the connection between driver and machine. Over 200 submission were received and the winning design was announced last week. Read More
If robots are going to work alongside humans, the machines are going to need to swallow their pride and learn to ask for help. At least, that's the thinking of computer scientists at the University of Washington (UW), who are working on ways for robots to crowdsource their problems when learning new tasks. If successful, this approach points the way toward future robots that are capable of asking for assistance to speed up their learning when it comes to figuring out how to carry out household tasks. Read More
The lion's share of open field at last month's Overland Expo was dedicated to camping trucks, trailers and RVs, but there were also a few other interesting vehicles sprinkled throughout. Arizona-based crowd-source automotive firm Local Motors brought two Rally Fighter off-roaders, which we took a look at in our Overland Expo round-up, along with its new Racer motorcycle. The stylish motorcycle blends classic and custom design elements to "define a new class of cruiser." Read More
A picture is worth a thousand words, but not if the picture is a blurry, pixelated mess. That's what SpaceX probably realized when it looked at the badly garbled video feed from the historic powered landing of a Falcon 9 booster last month. Having already had a go at cleaning up the video, the company has released the raw footage to the public in hopes of crowdsourcing the restoration effort. Read More
GE/Quirky partnership releases smart airconditioner
Air conditioners are a blessing in a hot climate, but with their thermostat minds they're almost like sticking a vacuum cleaner in your wallet. To help remedy this, GE and Quirky have launched the Aros smart air conditioner; the first major connected appliance of the partnership. This Wi-Fi-enabled air conditioning unit uses Quirky's WINK app to learn its owner's habits and adjust itself accordingly, so it keeps the home cool without breaking the bank. Read More
Gamers outshine computers in crowdsourced RNA modeling
Results from the crowdsourced game and experiment, EteRNA, which combines RNA folding puzzles with laboratory synthesis, show that human gamers are able to develop better models of RNA folding than previous computer algorithms. Design rules formulated by the online community have even been used to construct a new algorithm, EteRNABot, and in some cases represent completely new understandings about RNA folding that have yet to be explained mechanically. Read More
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8th January 2015 @ 11:35am
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text: Advertising Age magazine Published on May 28, 2013. 0 Reprints Reprints Ad Age LookBook Weekly Feature Ad Spending for 100 Largest B-to-B Marketers Nears $5 Billion Learn more Manager: Reach Marketing Former manager: MeritDirect Description: Professionals in the marketing and media industries, including executives, media buyers and planners, account execs, marketers, brand and product managers, and creatives Number of names: 58,650 Price: $150/M postal, $300/M email In this article: BtoB Advertisement Read These Next Pepsi Passes Diet Coke in Market Share as Artificial Sweeteners Fall Out of Favor E.J. Schultz on 03.26.2015 49 0 See Five of Asia's Best Campaigns From AdFest Normandy Madden on 03.26.2015 48 0 Women Make Up 31.5% of Cannes Lions Juries For 2015 Emma Hall on 03.26.2015 41 0 Comments (0)


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Oct. 12, 2013
Recap | Final Stats | Quotes | USATSI Gallery | Photo Gallery 2 | Photo Gallery 3 | Photo Gallery 4
- Saturday's attendance of 26,022 is the largest for a game at Hughes Stadium since Oct. 15, 2011 vs. Boise State (30,027).
- Saturday's loss to SJSU snapped a five-game home win streak, the longest since 2007-08. It also snapped a three-game home Mountain West win streak, which was the longest since 2005.
- DL Josh Lovingood registered his first career start. He is the third true freshman to start for Colorado State this season joining WR Rashard Higgins and LB Deonte Clyburn.
- SO WR Charles Lovett, who missed the first five games with a knee injury, entered the game on the Rams' first drive today. Lovett finished the game with four receptions receptions for 49 yards. He now has a catch in 13-straight games he has played in. His last game without a catch was Nov. 19, 2011 vs. TCU.
- JR QB Garrett Grayson connected with SR TE Crockett Gillmore for a 15-yard touchdown on the Rams' first drive of the game. It was Gillmore's first touchdown of the season. He became the fifth different Ram to catch a touchdown pass this season.
- On its first drive, CSU marched down the field and scored in seven plays. In all three home games this season, the Rams have scored touchdowns on their first drive, and have done so in four consecutive home games dating back to last season.
- Tight ends Gillmore and Kivon Cartwright combined for eight receptions for 167 yards and three touchdowns. Gillmore led the Rams with five receptions for 76 yards and Cartwright had three catches for a career-high 91 yards and two touchdowns, which tied a career-best.
- Grayson finished Saturday throwing for a career-best 310 yards and three touchdowns, which tied a career-high.
- Grayson became the first Colorado State quarterback to throw for 300 yards in back-to-back games since 2010 when Pete Thomas threw for 305 yards at Miami Ohio and 386 at home vs. Idaho.
- Grayson hit JR TE Kivon Cartwright for a 50-yard touchdown to put the Rams up 17-10 with 2:30 left in the half and a 35-yard score just 1 minute and 28 second later (at 1:02). The 50-yard reception is a career-long for Cartwright, and the two TDs give him four in the last two games.
- DL Terry Jackson returned after missing the past two games with concussion-like symptoms.
- DB Trent Matthews picked off SJSU's David Fales in the end zone. The interception, which ended the Spartans 66-yard drive, was Matthews' second interception of the season and the third of his career.
- Early in the second quarter, SJSU QB David Fales connected with RB Jarrod Lawson for an 83-yard touchdown. It is the longest touchdown pass given up by a CSU defense since Nov. 17, 2001 at New Mexico. QB Casey Kelly hit Dwight Counter for an 85-yard touchdown.
- JR kicker Jared Roberts connected on 27- and 47-yard field goal. In his career, Roberts has a field goal percentage of 90.5% (19-21), which is the second-highest nationally among active kickers.
- The drive that resulted in a 27-yard Roberts field goal was CSU's longest drive of the season in terms of plays and time (16-7:15). It is the longest scoring drive since Dec. 3, 2011 vs. Wyoming (16-7:27).
- On their first possession of the second half, San Jose State methodically worked its way down the field and scored after a 7:16 drive. It is the longest drive of the season for a CSU opponent.
- SO RB Kapri Bibbs has back-to-back games with a rush of 30 yards or longer. He is the first Rams running back to accomplish this feat since Chris Nwoke in 2011. On Oct. 29 at UNLV, Nwoke rushed for a long of 38 and the next game, Nov. 12 vs. San Diego State, he scampered for a 67-yard touchdown.
- The Rams' defense recorded six tackles for loss. Entering the game, CSU averaged 5.4 tackles for loss per game.
- LB Aaron Davis recorded his first career forced fumble, forcing the Spartans into a fourth and goal. Davis also tied a career best with 13 tackles.
- LB Max Morgan set a career high with 14 tackles (six solo).
- Today's captains were LB Nu'uvali Fa'apito, QB Garrett Grayson, LB Cory James and OL Ty Sambrailo
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I am a founder of a social media startup based in Los Angeles. Since my company is in the early stages I am always looking to keep my travel expenses down. :-) Typically when I'm travelling I am at meetings all day and generally just want to catch up on emails and crash at night.
In my spare time I love to explore new places, meet new people and most importantly eat great local food. Worked in music for many years and continue to have a love for live music.


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Count Of Monte Cristo
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|Format: Paperback
Number of Pages: 1136
Vendor: Penguin Classics
Publication Date: 2003
|Dimensions: 7.75 X 5.13 X 0.25 (inches)
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Publisher's Description
"On what slender threads do life and fortune hang"
Thrown in prison for a crime he has not committed, Edmond Dantes is confined to the grim fortress of If. There he learns of a great hoard of treasure hidden on the Isle of Monte Cristo and he becomes determined not only to escape, but also to unearth the treasure and use it to plot the destruction of the three men responsible for his incarceration. Dumas' epic tale of suffering and retribution, inspired by a real-life case of wrongful imprisonment, was a huge popular success when it was first serialized in the 1840s.
Robin Buss's lively English translation is complete and unabridged, and remains faithful to the style of Dumas's original. This edition includes an introduction, explanatory notes and suggestions for further reading.
For more than sixty-five years, Penguin has been the leading publisher of classic literature in the English-speaking world. With more than 1,500 titles, Penguin Classics represents a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.
Author Bio
Alexandre Dumas (18021870) was the son of Napoleon's famous general Dumas. A prolific author, his body of work includes a number of popular classics, including The Three Musketeers and The Man in the Iron Mask.
Robin Buss (19392006) was a writer and translator who worked for the Independent on Sunday and as television critic for the Times Educational Supplement. He was also the translator of a number of volumes for Penguin Classics.
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By Rusty Whitcher
There are amusement parks with legendary roller coaster which have loops, turns, twists, highs and lows which leave riders with their hearts jumping from their throat to their stomachs to everywhere in between.
And then there is the Hesston College softball season which may leave all of those wild rides in the dust with all of the ups and downs.
In just 24 hours the Larks went from the peaks, to the bottom of the valley, back to the top of the mountain during action on the weekend of March 20 and 21. The Larks hosted both Neosho County Community College and Allen Community College, coming away with an epic meltdown against Neosho in game one, blasted in game two only to recover with a double header sweep of highly favored Allen Community College the second day.
Hesston led Neosho 4-3 heading into top of the seventh of game one. The wheels came off in spectacular fashion as the Larks allowed eight runs in the first half of the final inning before losing 11-5. Game two was a moot point as the Larks watched Neosho blast balls through holes in a 14-2 routing.
However, instead of packing up the shop, the Larks recovered the following day. Hesston took advantage of some Allen miscues to pull away for a 4-2 victory in the first game. The second game was scoreless through four and a half innings when the Larks scratched two across in the bottom of the fifth. Allen scored one run in the top of the seventh and had two on with none out. A great double play by Lark third baseman Daisy Correa erased the threat and Hesston closed out the 2-1 victory with a routine ground out.
The wins moved the Larks to 10-12 on the season.


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How easy is it to get a Python that isn't linked to GNU Readline on FreeBSD or OpenBSD? Is GNU Readline the default for Python readline-like support on these systems? If so, is it easy to remove this dependency?
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free, no registration required.
On FreeBSD, libreadline is part of the base system (unless you've rebuilt that without GNU). Python loads that dynamically;
There is no configure option to remove it from the Python build.


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PSG 1 Valencia 1 (agg 3-2): Beckham celebrates from the bench as Lavezzi secures progression to the last eight
David Beckham led the celebrations as Paris Saint-Germain slugged rather than sashayed their way through to the Champions League quarter-finals after drawing with Valencia at the Parc des Princes.
It took the jolt of a fine Valencia goal from Jonas early in the second half to rouse the home side, and Ezequiel Lavezzi's equaliser secured a draw on the night and a narrow aggregate win.
It was Lavezzi's second goal of the tie after he and Javier Pastore scored in Spain three weeks ago. PSG were in full control at the Mestalla until a dramatic injury-time period saw Adil Rami pull a goal back and Zlatan Ibrahimovic sent off, making tonight's second leg increasingly complicated on two counts.
Just about: Ezequiel Lavezzi bundled home the equaliser before receiving a yellow card for removing his shirt
Nice tats: Lavezzi showed off his tattoos, including Jesus and compatriot Diego Maradona
Paris Saint-Germain: Sirigu, Thiago Silva, Alex, Maxwell, Matuidi, Chantome, Jallet (Van der Wiel 27), Motta (Gameiro 58), Lucas (Sakho 83) Moura, Lavezzi, Pastore
Subs not used: Douchez, Camara, Armand, Beckham
Goal: Lavezzi 66
Booked: Lavezzi
Valencia: Guaita, Cissokho, Barragan, Ruiz, Mathieu, Albelda (Banega 46), Feghouli (Piatti 63), Parejo, Facundo Costa, Jonas (Valdez 76), Soldado
Subs not used: Diego Alves, Joao Pereira, Guardado, Canales
Booked: Ruiz, Albelda, Soldado, Parejo
Goal: Jonas 55
Referee: Milorad Mazic
Ibrahimovic was given a two-match ban
by UEFA, and the Sweden striker was certainly missed on the field for
this return leg as he watched from the stands. Without him, the home
side were toothless in the first half.
They certainly did not appear a side capable of reaching the Wembley final on May 25, but on they go.
Those looking for romance forged at home in the story of Parisian resurgence might prefer to overlook the fact it has been funded by overseas money, since the 2011 takeover by the Qatar Investment Authority.
Their budget is more Champions League than Ligue 1, and the personnel brought to the Parc des Princes over the last two years reflects it.
The sudden wealth means tangible success in Europe is a requisite, so winning in Spain three weeks ago was not the achievement it might have been considered before the takeover and more another step in the plan for growth.
PSG are unbeaten in their last 23 European home matches now but they were clinging on at the end as Valencia sought the goal that would have forced extra-time.
Overjoyed: David Beckham celebrates Lavezzi's equaliser from the sidelines
Pick that one out: Jonas rifled Valencia into the lead in the second half
Game on: Jonas celebrates his stunning goal after half-time to bring Valencia back into the tie
Twisting: Lucas (left) turns away from his marker Jeremy Mathieu
With Ibrahimovic and Marco Verratti suspended, and winger Jeremy Menez injured, manager Carlo Ancelotti - who won the Champions League in 2003 and 2007 with AC Milan - had a weakened hand before kick-off.
Lucas started alongside Lavezzi in attack.
There was no room in the starting XI for Beckham, squeezed out of central midfield by Thiago Motta and Blaise Matuidi. The former England captain was primed on the bench but stayed there.
PSG fans might have been wary that their expensively-assembled team are prone to aberrations, such as their league defeat to Reims at the weekend.
Jonas almost got in behind the home defence in the eighth minute but a foot in by Christophe Jallet denied him.
Valencia had a further chance when Jonas linked up with strike partner Roberto Soldado. Salvatore Sirigu smothered his low 15-yard shot.
Ouch: Blaise Matuidi lies on the turf after taking a hefty challenge
Putting the boot in: Lucas Moura (right) swings in a cross
Jonas sent a 20-yard shot bobbling wide, and Tino Costa cracked an ambitious effort several yards off target.
Sirigu palmed away a stinging 20-yard drive from Jonas just before the break, but it was a ball he might have caught.
From the corner that followed, Costa struck the ball so sweetly it was missed by everyone in blue and red, and also his team-mates as it swerved wide of the far post.
Limbering up: Beckham stretches ahead of Paris Saint-Germain's match
Eyes on the prize: The former England captain performs some kick-ups ahead of the game
Waiting in the wings: Beckham warms up ahead of the clash with Valencia
Benched: Beckham started the match on the sidelines
Ever Banega stepped out in place of Albelda for the second half, an attacking move by Valencia.
Jonas made the breakthrough in the 55th minute with a crashing 25-yard drive inside the left post.
Valencia had more zip about their game, but PSG were level 11 minutes later though and it was Lavezzi who woke the home crowd from an understandable stupor. Kevin Gameiro, on in place of Thiago Motta, bustled through a couple of challenges before the ball rolled kindly for his team-mate.
Vicente Guaita repelled Lavezzi's 15-yard blast but could then do nothing to prevent him tucking the ball over the line with his knee.
Clement Chantome's 25-yard swipe drew a solid save from Guaita, with PSG on top for perhaps the first time in the match.
Valencia poured pressure on the Paris goal in the closing minutes but they struggled to get in behind as their campaign reached its end.
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CARDIFF, Calif., May 6, 2014 /PRNewswire/ -- NI Research has released the May issue of NeuroPerspective, which features
Pilot Study Reveals a Majority of Medication-Free Patients Treated with NeuroStar TMS Experienced Remission After Six Weeks with Durable Effects Through Three Months NEW YORK, May
GeneSight Psychotropic Expands to Cover 38 FDA-Approved Antidepressant and Antipsychotic Medications MASON, Ohio, May 4, 2014 /PRNewswire/ -- Assurex Health today announced an enhancement
Typically, diagnosing depression involves discussions about symptoms with a doctor or a therapist. It isn't an exact science, because until now, there wasn't an empirical test for most mental illnesses.
Expert advice to take the mystery out of treating and living with adrenal fatigue. Indianapolis, IN (PRWEB) April 29, 2014 Adrenal fatigue can weaken
A new study from the University of Wisconsin-Madison reveals that marital stress could make people more susceptible to depression.
End Your Depression created by Cecil Ellis is a new program that gives people techniques, tips, and detailed instructions on how to eliminate depression from their life.
Researchers at UNSW Australia have for the first time used electrical pulses delivered from a cochlear implant to deliver gene therapy, thereby successfully regrowing auditory nerves.
DUBLIN, Apr.
BEVERLY HILLS, Calif., April 18, 2014 /PRNewswire/ -- The menopause transition period brings many uncomfortable symptoms.
- An aromatic woolly plant (Origanum dictamnus) native to Crete, formerly believed to have magical powers.