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Yamaoka, Kanagawa
Atsuhiro Yamaoka, Kanagawa JP
|Patent application number
|INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESSING METHOD - There is provided an information processing apparatus including a user information manager that registers, in a database, registered device information in which devices specified by a user from among devices capable of realizing functions by linking together are associated with the user, a recommended function determiner that acquires, from the database, function information in which the functions and the devices are associated, and determines recommended functions for the user on the basis of the function information and the registered device information, and a procedure information manager that acquires, from the database, procedure information indicating operating procedures for realizing a function that the user selects from among the recommended functions, and provides the procedure information to the user.
|INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND PROGRAM - An information processing apparatus includes a communication unit, a storage unit, and a controller. The communication unit is configured to be able to download arbitrary application data from a service on a network in which first application data encoded by a predetermined system and second application data encoded by another system or unencoded. The storage unit is configured to store decoding information for decoding the first application data. The controller is configured to be able to decode the first application data using the decoding information to install a first application obtained by decoding the first application data.
Hironori Yamaoka, Kanagawa JP
|Patent application number
|BELT SKEW CORRECTING DEVICE, BELT DEVICE, AND IMAGE FORMING APPARATUS - A belt skew correcting device corrects a deviation of an endless belt which is supported by a plurality of rollers and which is driven to rotate around the plurality of rollers. An inclined sectional surface of a dislocating member is guided by an inclined sectional surface of a guide member in accordance with a following movement of a following member, so that a rotational shaft of one roller is given a tilt corresponding to an amount of the movement of the endless belt along the rotational shaft, and thereby the one roller can be tiled.
Hiroto Yamaoka, Kanagawa JP
|Patent application number
|Corner Joint Structure for Bridge Pier and Method of Producing the Same - An end face (
|STIFFENED PLATE AND A METHOD OF PRODUCING SAME - A stiffened plate obtained by welding one or a plurality of stiffening materials (
Katsushi Yamaoka, Kanagawa JP
|Patent application number
|POLYETHER ESTER BLOCK COPOLYMER - To provide a polyether ester block copolymer which has surface hardness suitable to be applied to a structural member and excellent in sound deadening quality and tribological property, a polyether ester block copolymer of the present invention comprises (a) aromatic dicarboxylic acid unit, (b) 1,3-propanediol and/or 1,4-butanediol unit and (c) long chain diol unit mainly including polyoxytrimethylene glycol, wherein the durometer hardness (type D), measured according to the principle of the method described in JIS K6253, is 40 or larger and 78 or smaller.
Makoto Yamaoka, Kanagawa JP
|Patent application number
|METHOD FOR MANUFACTURING NEURAMINIC ACID DERIVATIVES - A method for manufacturing neuraminic acid derivatives is provided, also synthetic intermediates of the neuraminic acid derivatives and methods for their manufacture, and neuraminic acid derivatives having high purity.
|METHOD FOR MANUFACTURING NEURAMINIC ACID DERIVATIVES - Methods for manufacturing neuraminic acid compounds and synthetic intermediates of neuraminic acid compounds, including a method for manufacturing a compound represented by
|METHOD FOR MANUFACTURING NEURAMINIC ACID DERIVATIVES - A method for manufacturing a compound represented by the formula (13):
Patent applications by Makoto Yamaoka, Kanagawa JP
Masakazu Yamaoka, Kanagawa JP
|Patent application number
|Hermetic Compressor - A hermetic compressor that has a pedestal of the valve plate to which a discharge reed equipped with an opening/closing part and discharge reed holding part, a spring reed equipped with a movable part and spring reed holding part, and a stopper equipped with a regulation part and stopper holding part, are fixed in this sequence, and also has a discharge valve device in which the spring reed is shaped in a substantially crank-like form is provided. A space is formed between the movable part of the spring reed and the opening/closing part of the discharge reed, and both are not adsorbed each other, thus preventing a delay in closing of the discharge reed. This makeup suppresses a decrease in freezing capacity of a fridge-freezer device and the like, thus implementing higher efficiency.
|Hermetic compressor - Stopper contains abutment section at a position that corresponds to arm section so as to keep a clearance from arm section of discharge reed. The structure above allows discharge reed to have two-stage spring characteristics; discharge reed exhibits a weaker springiness until arm section abuts against abutment section, and then exhibits a stronger springiness after the abutment. Employing the discharge reed having the two-stage characteristics allows discharge valve unit to easily open and quickly close without delay. Such structured hermetic compressor enhances energy efficiency, preventing degradation in refrigeration performance.
|Hermetic compressor - A hermetic compressor including a discharge valve system in a cylinder. A discharge valve system includes a discharge reed having an opening/closing portion and a discharge reed holding portion, a spring reed having a movable portion and a spring reed holding portion, and a stopper having a regulation portion and a stopper holding portion. The discharge reed, the spring reed and the stopper are fixed in this order to a pedestal of a valve plate. At a spring reed bending portion provided in a movable portion, the movable portion is bent toward the direction of the valve seat and the tip portion is brought into contact with the plate contact portion. Space is provided between the movable portion of the spring reed and the opening/closing portion of the discharge reed, and both are not brought into close contact with each other. Thus, delay in closing discharge reed can be prevented and deterioration of the refrigerating capacity can be suppressed.
|HERMETIC COMPRESSOR - In a stopper, by providing, in a position corresponding to a movable end vicinity of a discharge reed, a first regulation part having a predetermined clearance from the movable end vicinity of the discharge reed, since a hermetic compressor has such a two-stage spring characteristic that, until the movable end vicinity of the discharge reed touches the first regulation part, a spring characteristic is weak and, after the touch, the spring characteristic is strong, and there is obtained a discharge valve device which is easy to open and whose closing speed is rapid, it is possible to improve a delay in closing.
Ryo Yamaoka, Kanagawa JP
|Patent application number
|LIQUID CRYSTAL DISPLAY DEVICE AND ELECTRONIC APPARATUS - Disclosed herein is a liquid crystal display device having a liquid crystal between a drive substrate and a counter substrate, and a plurality of main pixels disposed so as to compose a display area, wherein either a liquid crystal alignment controlling factor or a spacer for substrate distance setting is provided in each of at least two sub-pixels of a plurality of sub-pixels composing the main pixel; and light shielding members provided in the at least two sub-pixels so as to correspond to either the liquid crystal alignment controlling factors or the spacers, respectively, are different in area in planar view from each other.
Shigenori Yamaoka, Kanagawa JP
|Patent application number
|Manufacturing Method of Display Unit and Manufacturing Apparatus of Display Unit - [Problem to be Solved] To continuously manufacture display units, and prevent warping or peeling of display units after sticking together, and eliminate mixture of air babbles, and prevent the occurrence of uneven images.


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A composition for eliminating an infection in a body space or cavity or on the epidermis of the body of the user is formed from an antimicrobial active agent which is, preferably, a fatty acid or mixture of fatty acids, an organic acid and a hydrotroper solubilizer. This composition in concentrate form can be diluted or admixed with the deionized, pyrogen-free water to form an effective use solution. The active ingredients herein are either UPS or food grade components.
1. A method for eliminating microbial contamination caused by bacteria, bacterial spore forms, antibiotic resistant bacteria and fungi in the internal spaces and tissues of the body having a pH greater than 5.0 of an individual in need thereof, comprising:
contacting the internal space or tissue to a bacterial arresting amount of a liquid composition consisting essentially of:
a) a microbial arresting agent selected from the group consisting of an aliphatic fatty acid, an aromatic fatty acid or mixtures thereof, the fatty acid having from about 6 to about 20 carbon atoms;
b) a hydrotrope;
c) a hydrotrope compatible acid; and
d) transport medium consisting essentially of deionized, pyrogen free water.
2. The method of
3. The method of
4. The method of
5. The method of
6. The method of
7. The method of
8. The method of
a) the antimicrobial compound comprises from about 0.1% to about 15%, by weight, based on the total weight;
b) the hydrotrope comprises from about 0.1% to about 30%, by weight, based on the total weight;
c) the hydrotrope compatible acid comprises from about 0.1% to about 50%, by weight, based on the total weight; and
d) the balance is a transport medium vehicle for the composition.
9. Method of
10. Method of claims 1 wherein the transport medium is an isotonic solution of a sugar in pyrogen free water.
11. Method of
12. The method of
13. The method of
14. The method of
15. A method of
16. A method of
17. The method of
18. A method of
19. The method of
20. A microbial contamination eliminating delivery system which comprises:
a) a container for temporarily storing a liquid composition,
b) a delivery tube for delivering the composition in the container to a body cavity, the delivery tube being in fluid communication with the content of the container, and
c) a quantity of liquid contained within the container for delivery into a body passage, the body passage being at a pH greater than 5.0, the liquid consisting essentially of:
(i) a microbial arresting agent selected from the group consisting of an aliphatic fatty acid, an aromatic fatty acid, and mixtures thereof the fatty acid having from about 6 to about 20 carbon atoms;
(ii) a hydrotrope;
(iii) a hydrotrope compatible acid; and
(iv) transport medium consisting essentially of deionized. pyrogen free water.
1. Field of the Invention.
The present invention relates to the use biocidal compositions of matter to eliminate infections from various body cavities. More particularly, the present invention concerns the use of biocidal compositions for eliminating infections in the thoracic cavity, abdominal cavity, synovial spaces, urinary bladder, lungs, sinus cavities, external auditory canal, oral pharynx, pericardial space, and the like by microorganisms and viruses. Even more particularly, the present invention concerns the elimination of infections including pathogenic microorganisms including Gram negative and positive bacteria, yeast, fungi, rickettsia and the like as well as normally nonpathogenic microorganisms present in the body cavities or spaces, which spaces or cavities do not normally harbor or support the growth of such organisms.
2. Prior Art
It is recognized and well documented that microorganisms present in the internal spaces and tissues of the body can cause disease i.e. infection, leading to physical debility of the animal or person and may even cause death. Today, typically, microorganism infection is normally treated with antibiotics. Antibiotics are made from compounds that interfere with the normal growth and proliferation of microorganisms. The action of these antibiotics involves specific interference with cell wall synthesis, protein synthesis or the like in the bacteria as they attempt to proliferate. There are analogous compounds prescribed for the treatment of fungal and yeast infections. There are a limited number of medications that interfere with the proliferation or viruses and viral particles in host cells preventing disease or discomfort normally caused by the virus.
Antibiotics normally act by interfering with biochemical mechanisms internal to the microorganism. Antibiotics are used as topical creams but are primarily administered either orally or in injectable form. The antibiotic then circulates through the blood stream and permeates the infected tissue where it comes in contact with the infecting organisms.
It is widely recognized by medical practitioners that the use of antibiotics has several problems and limitations that can lead to unwanted side effects or ineffective action against the infecting organisms. It is also recognized that any one antibiotic is effective against a limited spectrum of microorganisms and that this limited action frequently requires the medical practitioner to evaluate the effectiveness of the antibiotic in vitro prior to use which test is referred to in medical practice as a culture and sensitivity assay. The use of an antibiotic that is not active against the specific microorganism involved in the infection will not eliminate the infection and can actually accelerate growth of the organism by eliminating competing organisms leading to further progress of the resulting disease.
On the other hand testing for effectiveness of an antibiotic can delay treatment and result in further progress of the infection which can lead to severe consequences including death and hence the medical practitioner will usually take samples of the infecting microorganism for testing and start the patient on a broad spectrum antibiotic while waiting for the test results. The use of an antibiotic that is not effective against the infecting organism, however, can actually cause an increase in the growth of the infecting organism as stated.
Further, complications from the use of antibiotics can result from microorganisms developing resistance to the antibiotic. Microorganisms can develop resistance to antibiotics by exposure to subinhibitory levels of the antibiotic which subinhibitory levels allows the growth of any bacteria present that have only marginal susceptibility. Once the resistant strains proliferate, they become the dominant organism causing infection. Though not as common, strains of bacteria have been know to develop resistance to antimicrobial compositions of matter used for sanitizing and disinfecting inanimate surfaces and objects. The overuse and incorrect use of antibiotics in recent years has led to the emergence of bacteria that are resistant to all known antibiotics and present a severe health threat throughout the world. These organisms include but are not limited to antibiotic resistant tuberculosis, methicillin resistant Staphylococcus aureus and vancomycin resistant enterococci. While new antibiotics are continuously developed to deal with this problem it is recognized that the use of compounds such as those found in antibiotic compositions that interfere with normal biochemical mechanisms of growth and proliferation of microorganisms is likely to ultimately lead to the development of strains of bacteria resistant to the new compounds as well.
Hence, there is a serious and pressing need for the development of medications and methods of treatment of infections by bacteria, yeast, mold, rickettsia, viruses and the like that do not have the limitations and side effects observed with antibiotics.
Compositions of matter that kill microorganisms by direct action on the cell wall, referred to as cell lysis, are broadly known and are referred to as biocidal agents. These agents are used to eliminate microorganisms from various surfaces and materials including the surface of the body. Biocidal agents are not capable of circulating through the blood stream and permeating tissues and hence must be applied directly to the offending microorganisms.
Those skilled in the art recognize many biocidal compositions which employ a variety of substances as the active agent including, for example, quaternary ammonium compounds, halogens, fatty acids, anionic surfactants, organic acids, and sulfated and sulfonated aliphatic acids. For example, U.S. Pat. No. 5,143,720 to Lopes discloses mixtures of anionic surfactants and organic acids for use as mouthwash and as bactericides for food and food processing equipment. U.S. Pat. No. 4,404,040 to Wang discloses sanitizing concentrate compositions comprising an aliphatic short chain fatty acid, a hydrotrope or solubilizer for the fatty acid and an acid to produce a pH between 2 and 5 when diluted with water for use in food processing systems. U.S. Pat. No. 4,715,980 to Lopes, et al. discloses sanitizing compositions comprising a dicarboxylic acid and an acidic component that produces a pH below about 5 when diluted with water. U.S. Pat. No. 3,867,300 to Karabinos, et al. discloses bactericidal compositions containing a monocarboxylic fatty acid is protonated making the acid hydrophobic.
While the protonated and hence hydrophobic form of fatty acids is far more biocidal than the unprotonated, hydrophilic form, the hydrophobic form is insoluble in water. The use of a hydrotrope to solubilize the hydrophobic form of fatty acids allows them to remain in solution at a pH below 5.0. It is the use of the protonated form of fatty acids in the presence of suitable hydrotropes that allows complete elimination of microorganisms from internal body spaces or organs in animals and man, which elimination results in the cure or arrest of the associated disease state.
However, as is known to those skilled in the art to which the present invention pertains, the internal organs and spaces of the body of man or animals ordinarily secrete fluids rich in protein and inorganic ions that act to maintain the pH of that tissue or space between about 7.0 to about 7.8. The only tissue or space in the animal body that has a pH below 5.0 is the stomach. The contents of the stomach are emptied into the small intestine and in the first few centimeters of the small intestine secretion from the pancreas acts to raise the pH to 6.5 or above.
There are further complicating aspects of biology that limit the use of biocidal compositions in the internal spaces and organs. The proteins, glycoproteins, lipoproteins, lipids and phospholipids and the like that are secreted from many tissues will act to nourish and harbor microorganisms from direct attack by biocidal compositions of matter. It is a critical aspect of antibiotics that they are able to penetrate most tissues and secretions of the body and hence enter the cell body of the offending microorganism to stop growth of that organism.
Hence the use of fatty acid-based biocidal compositions in the spaces and organs of the body of man and animals to eliminate disease caused by microorganisms will have very limited efficacy unless the pH of the composition is maintained below about 5.0 and, preferably, below about 4.5 by the inclusion of an appropriate organic acid and unless a suitable surfactant is used to expose the microorganism to the biocidal action of the fatty acid.
It has long been recognized that biocidal compositions of matter employing fatty acids can be used to kill microorganisms on the outside of the body and on inanimate surfaces. It is nowhere mentioned in the art, however, nor has it been recognized nor is it readily apparent that these compositions of matter can be used in the internal spaces and organs of the body of man and animals at pH above about 5.0 to treat disease by the elimination of microorganisms.
Fatty acid based biocides are known in the art to be employed in the treatment of Helicrobacter pylori infections of the stomach. See, inter alia, Wider U.S. Pat. No. 6,071,761, the disclosure of which is hereby incorporated by reference. The stomach as described above, however, has a pH below 5.0 and the lining of the stomach is known to be able to tolerate low pH conditions without any damage or pathologic changes. Hence it is not readily apparent from this use nor is it suggested in any prior art that acidic compositions of matter employing fatty acids held in solution by appropriate hydrotropes can be tolerated or used in other areas of the body of man or animals. It is to this to which the present invention is directed.
The composition of the present invention meets the need for elimination of pathogenic organisms from the internal spaces or organs of animals and humans by direct contact with bactericidal and fungicidal agents, avoiding the use of antibiotics. Use of low levels of organic acid in the composition allows the fatty acid(s) to remain protonated but does not cause damage to the body tissues.
In accordance with the present invention there is provided a biocidal or antimicrobial composition, based on USP or food grade components for the treatment of microbial infections of the body spaces and organs of man or animals normally that normally have a pH of 5.0 and above, comprising:
(a) an antimicrobial active agent,
(b) a hydrotrope or solubilizer, and
(c) a hydrotrope compatible acid.
The composition may be in concentrate or a use solution. As a use solution, the concentrate is admixed with deionized, pyrogen-free water and may be rendered isotonic to body fluids by the addition of the appropriate amount of sodium chloride (NaCl).
The use composition hereof has a pH ranging from about 1.0 to about 5.0 and, preferably ranges from about pH 2.5 to about pH 4.0.
The composition hereof is administered as a liquid either orally or through a suitable delivery system, such as a catheter, an enema tube, needle or the like. Similarly, the composition may be administered as a solid in tablet or encapsulated form.
For a more complete understanding of the present invention, reference is made to the following detailed description and accompanying examples.
The present invention provides a composition and method for preventing and treating infection and disease causing microorganisms. As a concentrate, the composition hereof, generally, comprises:
(a) an antimicrobial active agent,
(b) a hydrotrope or solubilizer, and
(c) a hydrotrope compatible acid.
Optionally, a vehicle or extender may be used herein.
As a use solution, the concentrate is admixed with deionized, pyrogen-free water and may be made isotonic to body fluids by the addition of the appropriate amount of sodium chloride (NaCl). Similarly, and as discussed below, the composition may be administered in solid form, as well.
The use composition has a pH ranging from about 1.0 to about 5.0 and, preferably, pH 2.5 to about pH 4.0.
The Antimicrobial Active Agent
The antimicrobial active agent herein is one or more aliphatic or aromatic fatty acids either saturated or unsaturated, preferably, saturated, having from 6 to 20 carbon atoms and, preferably, from 8 to 12 carbon atoms. The fatty acid may be linear, branched or cyclic. Preferably, the fatty acid employed is food grade, linear, saturated and unsubstituted fatty acid. Representative of the fatty acids contemplated for use herein include caproic acid, caprylic acid, capric acid and lauric acid, as well as mixtures thereof. Preferably the fatty acid is a mixture of caproic and caprylic acids.
The Solubilizer
A solubilizing agent or stabilizer is employed to enhance the stability and hence the antimicrobial activity of the fatty acids. The use of fatty acids in the protonated state requires the presence of a solubilizing agent to dissolve the fatty acids in aqueous solution and to disrupt protective secretions from both the animal body and the microorganisms.
The antimicrobial action of short chain fatty acids is significantly greater in the protonated state as represented by R�COOH. Undissociated fatty acids have negligible solubility in water and the present invention employs a surfactant hydrotrope, coupler or solubilizer to bring the fatty acids into aqueous solution. Hydrotropes or solubilizers for fatty acids are well known in the art. The preferred solubilizer is non-toxic and retains fatty acids in an aqueous or isotonic use solution. Preferred solubilizers for use in the present invention included anionic surfactants such as alkylphosphates or phosphonates, sugar esters and alkyl glycosides, alkyl sulfates and alkane sulfonates, alpha olefin sulfonates, linear alkyl benzene or napthalene sulfonates, secondary alkane sulfonates, alkyl ether sulfates or sulfonates and dialkylsulfosuccinic acid esters. The choice of solubilizer is dictated by the risk of toxicity to man or animals. The preferred solubilizer is sodium lauryl sulfate.
Hydrotrope Compatible Acids
The present composition requires the presence of a hydrotrope compatible acid in sufficient concentration to provide a pH in the range of about 1.0 to about 5.0, and preferably from about 2.5 to about 4.0 in the use solution. The preferred acid should be compatible with product stability and most specifically not cause the chemical degradation of the hydrotrope. The acid used herein is generally a weak, organic acid such as, for example, citric acid, acetic acid, fumaric acid, maleic acid and the like as well as mixtures thereof.
Mineral acids will produce the same effect and may be used but the organic acids are preferred when sulfated or sulfonated hydrotropes are used due to instability in mineral acids. Citric acid is the preferred acid in the present invention.
Additionally, the use of citric acid provides added antimicrobial effects since citric acid is known to be biocidal.
The present composition when deployed as a liquid may be either a concentrated solution for dilution into a suitable vehicle or a ready to use solution. The present composition, generally, comprises, as a concentrate from 0.1 to 50% by weight of the fatty acid from 0.2 to 40% by weight of the hydrotrope and from about 0.1 to about 10% by weight of the organic acid, based on the total weight of the composition.
As a use solution, the vehicle is usually water or normal saline and the concentrate is present in amount ranging of from about 10 to about 5000 ppm of the fatty acid; from about 20 to about 4000 ppm of the hydrotrope and from about 10 to about 1000 ppm of the organic acid.
As noted, the composition may be disposed or associated with a delivery system such as, a catheter, a needle or an enema delivery device.
The present invention may be encapsulated or incorporated into other solid forms such as time release capsules and the like known in the medicinal arts.
Coating tablets or capsules with polymeric materials such as ethylcellulose, cellulose acetate phthalate copolymer, polysaccharide and the like (see, inter alia, U.S. Pat. No. 5,811,388) delays breakdown of the capsules or tablets until the tablet or capsule is past the stomach and upper gastrointestinal tract, thus, allowing the pH to remain below 5.0.
It is contemplated that the composition hereof be used for the treatment of infections of the �internal spaces� of the body of a human or animal. The term �internal spaces� is meant to include, for example, the thorax, abdomen, gastrointestinaltract, urinary bladder, vagina, nasal sinuses, external auditory canal, urethra, and the like.
It is also contemplated that the present composition be used for the elimination of microorganisms from exposed body tissues that normally are not exposed, such as the skin and underlying structure exposed by trauma or incision for or during surgery, or because of the introduction of surgical instruments or other such devices, such as vascular catheters and the like.
Similarly, the present composition may be used where infection is encountered. Thus, for example, the composition hereof can be used as an adjunct to peritoneal dialysis where there is a risk of infection of the abdominal cavity, which is commonly referred to as peritonitis in the medical arts. Though peritoneal infection is not common in long term maintenance, peritoneal dialysis is encountered every two to three years and can cause serious complications, including death.
During peritoneal dialysis, a hypertonic dialysis fluid is infused into the abdominal cavity and allowed to remain there for several hours after which it is drained and discarded. Peritoneal dialysis involves the use of a hypertonic dialysis fluid which is sterile and pyrogen free and is introduced into the abdominal cavity through a transcutaneous catheter.
As is known to those skilled in the art to which the present invention pertains, the use of transcutaneous devices has the risk of contamination with microorganisms and the introduction of these organisms into the interior spaces of the body. Introduction of microorganisms into the interior spaces of the body frequently leads to growth and proliferation of those organisms causing disease.
Although every effort is made to prevent the introduction of microorganisms into the abdominal cavity during peritoneal dialysis, it happens despite efforts to the contrary. Infections of the peritoneal cavity are serious and can be life threatening.
Introduction of the antimicrobial wash or use solution hereof into the abdominal cavity either separately or in the normal dialysis fluid provides a means of preventing or eliminating infection.
It is to be recognized that the composition hereof is also useful in treating infections of the abdominal cavity caused by factors other than peritoneal dialysis, including, but not limited to, trauma, surgery, perforated bowel, burst appendix, immune deficiency and the like. Furthermore, the present composition may be used to prevent or eliminate contamination of a site by microorganisms at a break in the epidermis (skin) of a man or an animal. The break can lead to the introduction of microorganisms into the tissues surrounding the site of entry or to internal body spaces or organs and result in infection and disease.
As noted above, infection is a potential complication of trauma, surgery, catheter introduction into body spaces or vascular structures and the like. While there are number of products available for preventing microbial growth at the site of entry or disruption of the epidermis, many of these products are based on conventional antibiotics or halogen compounds, specifically iodine and have proven to cause irritation of the skin following prolonged exposure or the development of antibiotic resistant microorganisms. Further, these products are not appropriate for introduction into the internal spaces of the body, including the subcutaneous tissues which are exposed following incisions during surgical procedures.
The present composition can be sprayed onto the skin about five minutes prior to surgical incision and wiped off and the application repeated two more times to eliminate all superficial microorganisms. The composition can also be sprayed into surgical incisions prior to closure of the incision to eliminate any microorganisms introduced into the wound or underlying body space or tissue. Likewise, it can be sprayed into wounds caused by injury from accidental trauma or laceration.
It is well known that the lower gastrointestinal tract of man and animals harbors a rich population of microorganisms, including aerobic, microaerophilic and nonaerobic Gram negative and positive bacteria and fungus. There have been over 400 different species of microorganisms identified in the colon of normal adult humans. The colonic flora is viewed as being essential to normal health and well being and the relative amounts of the various species of flora produces a balance that is critical to normal function. The present composition can be used to treat infection caused by microorganisms in the gastrointestinal tract.
It is well known, also, that imbalance in the normal flora or introduction of pathogenic organisms such as Salmonella or enteropathogenic E. coli into the GI tract can lead to discomfort and disease ranging from flatulence to life threatening diarrhea and chronic, hemolytic uremia. Further, it is suspected that microorganisms in the colon contribute to a number of disease entities such as inflammatory bowel disease, hypertension, psychiatric disturbance, diabetes, etc. Elimination of the diverse flora of the lower GI tract is difficult and requires prolonged use of one or more broad spectrum antibiotics which can take days to have an effect, allowing progression of the pathologic changes associated with infection. The present invention alleviates these problems typically associated with antibiotics.
The present composition may also be used a nasal spray for the elimination of both fungal or bacterial growth in the nasal sinuses. Fungal growth in the nasal sinuses has been identified in a high percentage of persons having chronic sinusitis and is believed to be the causative agent in producing chronic inflammation of the sinuses. Spraying can be achieved through any device, such as an atomizer spray device or the like.
For a more complete understanding of the present invention reference is made to the following non-limiting illustrative examples. In the examples all parts are by weight absent contrary indications.
This example illustrates the preparation of an antimicrobial composition in accordance herewith.
Into a suitable sterile vessel equipped with stirring is added to pyrogen-free, deionized water, at ambient conditions, the following USP ingredients:
The resulting composition is sterile and pyrogen free and has a pH of 3.5 and is isotonic to normal body fluids.
This composition has antimicrobial activity against a broad spectrum of microorganisms, including Gram negative and positive bacteria, bacterial spore forms, bacterial L forms, fungi and the like.
This example illustrates the antimicrobial activity of the composition of the present invention.
To illustrate the resistance of the present compsition to microorganisms, the composition of Example I is tested for antimicrobial activity against several clinical isolates of antibiotic resistant bacteria, including Vancomycin resistant enterococci (VRE), multi-drug resistant Pseudomonas aeruginosa and Methicillin resistant Staphylococcus aureus (MRSA).
A total of 150 clinical isolates of MRSA, VRE, and multi-drug resistant Pseudomonas aeruginosa are evaluated. Microdilution susceptibility is performed according to the National Committee for Clinical Laboratory Standard guidelines. Mueller-Hinton broth supplemented with calcium (25 mg/L) and magnesium (12.5 mg/L) (SMHB) is used for microdilution susceptibility testing. Hydrochloric acid (0.1 mM) is used to adjust the pH of the broth to approximately 4.5. Quality control strains are also tested with each experiment.
The lowest concentration of antibiotic with no growth is the minimum inhibitory concentration (MIC).
This example shows the resistance of the present invention to microorganisms.
Microorganisms can develop resistance to antibiotics by exposure to subinhibitory levels of the antibiotic which subinhibitory levels allows the growth of any bacteria present that have only marginal susceptibility. Once the resistant strains proliferate, they become the dominant organism causing infection. Though not as common, strains of bacteria have been known to develop resistance to antimicrobial compositions used for sanitizing and disinfecting inanimate surfaces and objects.
The composition of Example I is tested for the development of resistance to the composition in clinical isolates of enterococci, S. aureus and P. aeruginosa.
To determine if resistance develops after exposure to subinhibitory concentrations of the composition isolates of each enterococci, S. aureus and P. aeruginosa are selected for resistance studies. Minimum Inhibitory Concentration (MIC) of the composition is determined for each isolate by broth microdilution Bacteria (106 CFU/ml) are exposed to the subinhibitory concentration (��MIC). Bacteria (106CFU/ml) are then passed daily to fresh broth containing ��MIC. Following 5 passages, the MIC of the bacteria was evaluated by broth microdilution. This procedure is repeated for 30 passages or until an MIC increase of 2-4 fold is observed.
There is no observed change in the MIC after 30 passages indicating that the compositionndoes not lead to the development of resistant microorganisms.
To test the present compsition for tissue tolerance a series of tests are carried out to investigate the potential of the composition of Example I to cause discomfort or inflammation in the abdominal cavity or nasal passages, both body spaces being very sensitive to irritation and inflammation.
Seven normal rats are injected intraperitoneally with 0.5 ml of composition of Example I to test for tolerance of the product in the abdominal cavity. Seven control rats are injected with normal saline. There is no indication of discomfort in any of the rats. One hour following injection, the animals are sacrificed and the peritoneal membranes and organs examined. Post mortem examination indicates no inflammatory reaction, hyperemia or collection of fluid.
This example illustrates the use of the present composition as an adjunct to peritoneal dialysis to prevent or eliminate infection in the abdominal cavity. One liter of the composition of Example I is infused into the abdominal cavity of a human and allowed to remain there for 5 to 20 minutes after which time it is drained an discarded.
The volume of antimicrobial infused depends on the patient size, but should be enough to reach all surfaces in the abdominal cavity. Thus, usually 0.5 to 1.0 liter is ordinarily sufficient for infusion into the abdominal cavity of a human.
The composition here is also useful in treating infections of the abdominal cavity caused by factors other than peritoneal dialysis, including, but not limited to, trauma, surgery, perforated bowel, burst appendix, immune deficiency and the like.
This example illustrates the use of the present invention as a nasal spray. Two sprays in each nasal orifice three times a day is taken and allowed to remain for five to ten minutes before blowing the nose to clear remaining product. The product is used for three days. Spraying of the composition daily for a period of three days causes no irritation or rhinitis or any other perceptible discomfort.
This example illustrates the preparation of an antimicrobial composition in accordance herewith for gastrointestinal use.
Into a suitable sterile vessel equipped with an appropriate mixing device, is added at ambient conditions, the following USP ingredients:
The resulting composition is encapsulated into tablet form for oral administration.
The tablets or capsules are coated to prevent dissolution of the product in the stomach or upper gastrointestinal tract. The composition is taken 3 times a day until the pH of the stool is below 5.0, after which the tablet is taken for two more days.
This example illustrates the use of the present invention in treating achlorhydria.
The secretion of hydrochloric acid by the cells lining the stomach normally kills most microorganisms presented to the lumen of the stomach. Failure of the stomach to secrete hydrochloric acid is referred to in the medical arts as achlorhydria and is associated with bacterial and fungal growth in the stomach which can lead to discomfort and disease.
The composition of Example VIII is taken orally in tablet form to eliminate bacterial or fungal growth associates with achlorhydria. 900 mg of the concentrate is taken orally in uncoated encapsulated form following an overnight fast and, then, every four hours following with 50 cc of water.
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text: "This work includes a strobe light, smoke, and loud sound" read the disclaimer on the front of the Playbill for the performance of 'Vertical Road' by the Akram Khan Dance Company. But the powerful effects in this performance flowed from the dancers fluid motions, as choreographed by Akram Khan, garbed in earthy-toned, loose attire. His production was supported by music from Nitin Sawhney, the UK composer whose most recent work includes a concept album with William Hurt entitled Last Days of Meaning and the score for the movie Midnight's Children, though neither were present for the US performance.


text:
Pizza Hut manager arrested for spitting on cop's food
The woman recognized the officer as the man busted her for a DUI and decided to retaliate
By PoliceOne Staff
ERWIN, Tenn. — A Pizza Hut manager was arrested after an officer caught her spitting on his pizza as he waited to pick it up.
According to a police report, Sheriff's deputy Frank Rogers arrived at the restaurant after placing an order over the phone, and became suspicious when the woman behind the counter — who never asked for his name — told him it wasn't ready yet and began acting strange.
"As the defendant removed the pizza from the oven I observed her cut her eyes and look at me. The defendant then leaned over the pizza that she had began to slice, and I observed her spit on the pizza which had been purchased by me," Rogers wrote in his report.
He called attention to the matter and the woman, 29-year-old Amanda Engle, admitted that she knew who the officer was.
Unicoi County Sheriff Mike Hensley said Engle was acting in "retaliation" after Rogers arrested her for a DUI several months earlier, according to the Herald Sun.
Engle was placed under arrest for disorderly conduct and was fired from her position the following day.
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ADD & ADHD Health Center
News and Features Related to ADD & ADHD
Adult ADHD Underdiagnosed?
May 6, 2008 (Washington) -- The criteria used to diagnose adult ADHD are outdated, and as a result, many cases could be missed or misdiagnosed, researchers say. The problem, says James J. McGough, MD, is that the criteria are based in large part on diagnosing attention deficit hyperactivity disorderRead Full Article
ADHD: An Update on Diagnosis and Treatment for Kids
At age 4, Jeremiah Ryans routinely refused to wait in line at the water fountain at his summer day camp. Sometimes he'd get so cranky he would hit his classmates. But an alarm bell went off when he grabbed a pair of children's scissors and cut his teacher's hair. Just a kid being a kid -- or extremeRead Full Article
ADHD Summer Survival Tips
When her son Anthony was diagnosed with attention deficit hyperactivity disorder (ADHD) at age 6, Mary Robertson quickly became an amateur travel agent during his summer vacations. She didn't have much of a choice. "One day Anthony came home hiding a handsaw behind his back because he had sawed downRead Full Article
FDA OKs ADHD Drug Vyvanse for Adults
April 23, 2008 -- The FDA has approved the drug Vyvanse for the treatment of attention deficit hyperactivity disorder (ADHD) in adults, according to the drug company Shire, which makes Vyvanse. Vyvanse, a stimulant drug, was first approved by the FDA in 2007 to treat ADHD symptoms in children ages 6Read Full Article
ADHD Drugs: Heart Screen Recommended
April 21, 2008 -- Children and teens taking stimulants to treat attention deficit hyperactivity disorder (ADHD) should be screened for hidden heart problems, the American Heart Association now says. In an updated consensus statement released today, the organization recommends that in addition to a cRead Full Article
ADHD Drugs, Substance Abuse Not Linked
March 3, 2008 -- Children treated with stimulants for attention deficit hyperactivity disorder are no more likely to abuse drugs or alcohol during early adulthood than their untreated peers, new research shows. More than 100 boys were followed for 10 years after they were diagnosed with ADHD, and thRead Full Article
Heart Events Rare in Kids on ADHD Drugs
Dec. 5, 2007 -- Stimulants used to treat attention deficit hyperactivity disorder (ADHD) are known to raise blood pressure and heart rate, but serious heart complications seem to be rare among the children who take them, a new study suggests. The findings appear reassuring, but researchers say imporRead Full Article
ADHD Brain Matures, but Later
Nov. 12, 2007 -- ADHD (attention deficit hyperactivity disorder) may delay, but not prevent, the development of the brain's attention center. Researchers from the National Institute of Mental Health (NIMH) and Canada's McGill University reported that news today. The finding "should be reassuring toRead Full Article
Stimulants Help Students With ADHD
Sept. 19, 2007 -- Kids with attention deficit hyperactivity disorder (ADHD) who take Ritalin or other prescription stimulants are more likely to achieve long-term academic success than children with ADHD who don't take drugs. That is the finding from the longest and most comprehensive follow-up studRead Full Article
Many Kids With ADHD Aren't Diagnosed
Sept. 4, 2007 -- A new study shows that ADHD is grossly undiagnosed. An estimated 2.4 million children between the ages of 8 and 15 in the U.S. have attention deficit hyperactivity disorder (ADHD), but fewer than half of them have been diagnosed or are receiving appropriate treatments, researchers rRead Full Article


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For the Group Id Door, join this group. You can always get out of it after you test the place. http://www.roblox.com/My/Groups.aspx?gid=194713
Now for the friends door, send me a friend request. You can always delete me afterwards.
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My friend and food stylist Karen Stylist never fails to surprise me. On set, her nickname is "Ninja." She's quiet and stealthy, coming up with thoughtful nuances that make a shot. We've worked together on about six projects. For our New York City trip, she had a little hit list or restaurants, and Ippudo Ramen was on it.
Karen is singular in her resolve so I rarely mess with her. Plus she does her homework. Ippudo Ramen is a carefully styled Japan-export with only one outlet in the States – in New York's East Village. We had to go.
All week long, we planned our meals around our business appointments. However, for Ippudo Ramen, I ditched my conference so we could easily snag two seats for lunch. That Sunday afternoon, the wait was 30 minutes for the two of us. Larger parties had to wait at least an hour.
We only had room for two bowls of ramen and opted for the "special" of kasana black ramen made with a rich pork and chicken broth. (The "black" refers to black fermented garlic.) The other was shiromaru hakata ramen. "Hakata is where tonkotsu [milky rich pork broth that's so popular these days] came from. If they say Hakata, it's a promise of purity. I have to try it," Karen said. And so we did.
Before getting into nitty gritty, a sense of the place. Ippudo Ramen is carefully styled and ultra cool. Note the pants on the guy in the photo above. (It was dark and Karen had to shoot quick, hence the quality.) Fooling around with my iPhone, I made this little movie from our ramen lunch:


text:
Seahawks sing the praises of Brandon Mebane
The veteran's contributions to the Seahawks' defense may go unnoticed by some, but not by his teammates.
Instead, he'll sing.
"I'm just a nobody," the Seahawks' nose tackle sings -- and surprisingly well, by the way. "Trying to tell everybody, about somebody, who can save anybody."
That old Williams Brothers song is the perfect anthem for an interior lineman, so it's appropriate that one of the unsung heroes of the NFL's best defense is more interested in singing about being a nobody rather than talking about the Pro Bowl-caliber season he is enjoying.
"I'm just trying to do my job," Mebane says with a grin. "I'm just an employee of the Seahawks."
Although Mebane isn't interested in talking about one of the best seasons of his seven-year career, his teammates are more than happy to do so.
"I feel like he's very underappreciated in terms of not being, quote, unquote, a household name," defense end Red Bryant said. "But everybody in this locker room, everybody around the league knows who Brandon Mebane is. He's a phenomenal, phenomenal nose tackle, best in the game. I'm glad and lucky I get to play with him."
Mebane, the longest-tenured player on a roster that went through a major overhaul under coach Pete Carroll and general manager John Schneider, has always been a strong force in the middle of Seattle's defense, but in his seventh NFL season, he may be playing better than he ever has.
"He's even stronger now," said defensive coordinator Dan Quinn, who was Seattle's defensive-line coach in 2010. "Brandon's always been a guy inside that had really good strength. And one of the things that sets him apart throughout the league as a nose tackle, for a big guy, he's rarely on the ground, and that's easier said than done. There are so many combination blocks and double-team blocks where he gets underneath people and he can knock a guy back. He's really strong. When he gets underneath you, it's hard to deal with. One of the things that sets him apart is his balance."
Like any good interior lineman, Mebane's impact isn't measured in numbers, but rather by the way he can make a mess of a play for an offense, creating opportunities for his teammates. Take, for example, the first play of last week's game in which Mebane blew past Giants center Kevin Boothe, then ran through running back Andre Brown to flush Eli Manning out of the pocket. Red Bryant ended up getting credit for a quarterback hit on the play, an incomplete pass that helped lead to a three-and-out, but it was Mebane's ability to dominate two blockers that wrecked the play for New York.
Sure, sometimes Mebane is the man making the play -- his 145 tackles since 2011 rank fifth in the NFL among interior linemen -- but more often he is the guy keeping offensive linemen busy while other players collect the tackles and sacks.
"You just have to watch the tape," Bryant said. "He's not just doing it this year, he's got a body of work, he's been doing it for seven years. If you turn on the tape, you'll quickly know who Brandon Mebane is. He's been a big influence on me, and we respect him. It's unfortunate a lot of people might be under-appreciative of what he does, but we definitely know."
On the flip side, the improved line depth around Mebane has helped his game. With the addition of pass rushers Cliff Avril and Michael Bennett, and the play of defensive tackles Tony McDaniel and Clinton McDonald, opportunities have opened up for Mebane to make plays.
"He's been really consistent over the years; he's been a great player for us," Carroll said. "I think the guys around him have contributed to his play and I think just the three-technique play and Mike Bennett being a factor as an inside rusher, Tony has done a nice job too, as has Clinton McDonald. I think that's all fit together and it's just bringing out the best aspects of all of those guys. So it's kind of the chemistry of them."
Injury update
Three new names showed up on Thursday's injury report. Guard J.R. Sweezy (concussion) and cornerback Jeremy Lane (ankle) didn't practice, while running back Robert Turbin (groin) was listed as a limited participant. WR Percy Harvin (hip) sat out for a second straight day, while Zach Miller (ribs) returned to practice on a limited basis after sitting out the day before. S Kam Chancellor (quadriceps) was a full participant after sitting out Wednesday.
Roster moves
The Seahawks promoted receiver Bryan Walters off the practice squad to fill the roster spot vacated by cornerback Brandon Browner's suspension.
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text: Classic Dog Fetch Fail By Matt Hendricks October 20, 2011 2:11 PM Share on Facebook Share on Twitter Poor Puppy, can't figure this out. No Matter how many times he trys to slam his way though, it still won't work! Check out this, and see if you laugh or cry! Yay Puppy! Filed Under: dog Category: Grand Rapids News Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of 98.7 WGR Recommended For You Around the Web


text:
Connecting everyone, understanding the world, and building the knowledge economy are huge technical challenges. Engineers at Facebook move fast and push code up to twice a day to build infrastructure and products that provide global, real-time, and interconnected services for the 1.2 billion people who visit Facebook every month.
The mission of this site is to share our experiences with the unprecedented scaling challenges we face, to talk about our open source tools and technologies, and to help learn from - and solve important problems together with - the broader technology community.
Stay up-to-date via RSS with the latest open source project releases from Facebook, news from our Engineering teams, and upcoming events.Subscribe


text: If you want to rest, enjoy life, feel at home, release your stress you only have to visit this Health Resort . The people are unique and they give you a unique holiday experience for you mind and soul. The service is exceptional. My husband and I went there already 5 times. Please try it


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DEFINITION of 'Medicare Part D'
A prescription drug benefit program that was created through the U.S. Medicare Prescription Drug, Improvement, and Modernization Act of 2003. The "D" stands for "drugs". The program gives Medicare recipients these basic choices: stay in traditional Medicare without signing up for the prescription drug benefit outlined in the Act, stay in traditional Medicare and enroll in a Medicare drug plan, enroll in other Medicare plans, or enroll in a comprehensive private health plan (which may or may not cover prescription costs). The program began providing coverage for users on Jan 1, 2006.
INVESTOPEDIA EXPLAINS 'Medicare Part D'
Those who enroll in the Medicare Part D program choose from a large list of approved drug plans which do not cover all prescription drugs, so it is important that they choose a plan that meets their needs. Senior citizens and seniors' advocacy groups have criticized the program for not being comprehensive enough and adding to the already high costs of getting the drugs that seniors need for medical reasons. As a result of Medicare Part D, a number of insurance products are expected to cover the gaps in prescription drug coverage.
Medicare Doughnut HoleA range of total prescription drug spending in the Medicare Part ...
Medicare Part B PremiumsA monthly fee that Medicare participants pay for medical insurance ...
Medicare Catastrophic Coverage ...A government bill designed to improve acute care benefits for ...
MedicareA U.S. federal health program that subsidizes people who meet ...
Federal Poverty Level - FPLThe set minimum amount of gross income that a family needs for ...
MedicaidA joint federal and state program that helps low-income individuals ...
Don't Put Off Your Year-End Tax PlanFrom sales tax deductions to credit reports, check out what items should be on your financial checklist.
Options & Futures
Long-Term Care: More Than Just A Nursing HomeLearn what you can do now to keep your options open in the future.
Options & Futures
Getting Through The Medicare Part D MazeHaving trouble sorting through your prescription drug coverage options? We offer some solutions to the confusing process of selecting the right Medicare Part D coverage for you.
What Does Medicare Cover?Don't assume you're insured. Find out what you can expect from this healthcare program.
Filling In The Medicare GapsBasic Medicare is not a perfect fit for everyone - sometimes, extra policies are required to suit a person's needs.
How Advisors Can Help Clients with DementiaAdvisors may be called on to monitor and react to changes in their clients' mental acuity. Here's what to consider.
Helping Clients Choose Long-Term Care InsuranceThe need for long-term care has become an inescapable (and pricey) issue for retirees. Here's what financial advisors can do to help.
Stock Analysis
3 Things That Could Hold Intuitive Surgical BackTaking a long-term view that favors Intuitive Surgical developer increasing in value, doesn't mean that there are near-term headwinds facing this company.
Healthcare: What Are You Really Paying For?Long-term care costs rise fast and long-term care providers bundle services together, making it tougher for families to understand what they are paying for
4 Myths You Don't Know About MedicareHere are four common misconceptions about Medicare, the federal government's health insurance program for people who are 65 and older or disabled.


text:
Reports » UK
UK stock market commentary (July 10, 2014): Central Banks compete with drying paint for interest
European equities are set to open flat as the overnight FOMC minutes failed to rock any boats. A little tweaking to the end of quantitative easing and a reiteration of the open ended timescale for monetary tightening didn't give anything new for traders to pounce on. Similarly, the BoE is set to be equally static with no change on rates and asset purchases so attention is already shifting out to the minutes two weeks away.
Although speculation seems to have focussed solely on the possibility of rate hikes being brought forward, the economic back drop isn't tallying up quite so clearly. Despite Nemat Shafik and currency traders doing their best to push up the pound just in time for their summer holidays, following the drop in inflation, the cooling in the Services PMI and Mark Carneys flip flopping recently, you should probably get down to the bureau de change now and lock in the rates before the BoE kicks the issue of interest rate hikes into the long grass like the Fed.
Fresh optimism regarding corporate earnings season which kicked off yesterday with stronger than estimated results for Alcoa, allowed the Dow Jones to rebound 58 points to 16,992. It even overshadowed warnings by the Fed that investors could become too complacent about the economic outlook and also dissuading excessive risk taking.
The Federal Reserve's last meeting minutes did not clarify the timing of the interest rate hike announced for the next year. That upset currency investors who sold the greenback heading into the euro instead. As a result, the EUR/USD pair rebounded 30 pips to 1.36401 with concerns of a hawkish Fed keen to rebalance the rhetoric, being now priced out.
Its' driving season but the consumption in the world's biggest oil user failed to keep up which in turn pushed gasoline inventories higher as indicated by the weekly stockpiles report. Consequently, the WTI crude prices posted a sharp selloff yesterday, losing $1.53 to $101.93 with the geopolitical tension also becoming less of a concern.
Worries of a return to excessive risk taking era as shown in the FOMC meeting minutes has undoubtedly reignited demand for a safe haven. Good news for gold as usual with its price rallying $7.2 to $1326.9 and it appears still going strong this early morning, rising above the $1330.00 mark.
Stock Market Forum
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'Terrifically responsive dial pad'
'Hard, plastic case is not conducive to a ruggedized device'
'Good set of connectivity features'
'Great messaging device'
'Roomy QWERTY keyboard'
'Decent feature set'
'very sturdy phone'
'The Nokia E72 includes a full qwerty keyboard that is comfortable to type on.'
'Battery life is good however, offering an advantage over its touchscreen contemporaries by giving a couple of days between charges with average use.'
'it a very slim appearance'
'resistive screen'
'Like the Nokia N97, the N900's keyboard has one truly annoying feature: the space bar isn't in the center. '
'The smartphone will also be capable of video and audio playback, and offers up to 32GB of internal storage as well as a microSD memory slot capable of holding 16GB cards.'
'solid multimedia features'
'We were able to pair the smartphone with the Logitech Mobile Traveller Bluetooth headset and the Motorola S9 Bluetooth Active Headphones .'
'admirably sharp photos'
'more attractive phones'
'Pros Excellent screen.'
'generous 1,000-entry phone book'
'solid, substantial design'
'the phone didn't seem sluggish in applying our location data to pics.'
'The phone's various features are reasonably easy to locate in the menu system.'
'the phone sounded fairly clean, and callers had no trouble understanding us.'
'fairly weighty mobile'
'We've been able to install the necessary certificates and easily gain access to our office Exchange mail server and have new messages pushed to the phone.'
'Pros Classy design and build.'
'best phone'
'Navigation of the W810 menus is pleasantly intuitive, like most recent Sony Ericsson phones.'
'dedicated music controls'
'Switching between the cell phone and the music player is seamless, as music automatically stops when you receive a call.'
'The Quantum is heavy.'
'It's quite heavy at 4.7 by 2.3 by .6 inches (HWD) and 6.2 ounces.'
'Built for both business and entertainment, the LG Quantum is probably the most versatile of the latest Windows 7 phones, thanks to that generous QWERTY slider, while the Samsung Focus just flaunts a Super AMOLED screen and the HTC Surround specializes in Dolby sound on the go for the music and video addict. '
'The phone features a full QWERTY keyboard and a nice 3.5-inch WVGA resolution touchscreen display. '
'Best Budget Mobile Phone'
'In terms of build quality, the C3 feels really solid and Nokia has done well in putting together the phone with just the right amount of metal and plastic.'
'slick design'
'Very Good QWERTY Keyboard.'
ReviewGist helps you find the best products to buy by making sense of online reviews. We are currently aggregating 368,204 reviews covering over 29,103 products. See what the press says about ReviewGist here.
The Best Cellphone Buying Guide for 2014 is the definitive starting point for your next cellphone purchase.


text:
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text:
To celebrate her little bday, Mila learned how to grab things that are hanging above her. She also only took two naps and stayed up until 8:30pm farreando (partying) with us. (Note to self – drink no more coffe). She is the absolute joy of our life!
Baby M* – take note. This months is when it all started.
As Mila's due date approaches, my heart grows anxious thinking about how in just a few weeks our lives are about to change beyond our imagination. These last two trimesters of pregnancy have been so rich, so powerful and so different from the first, which led me to email my closest friends' to advice them against pregnancy. Today, as week 36 cruises by, I have a dancing Mila in my belly who has the power to control how much I can eat, breathe and pee by just adjusting her position slightly. The added unbalanced weight in my body has made me a slow walker and crossing the 100 meters of soft sand that separates our street from the Atlantic has become an almost "labor-inducing" trajectory. There are many things about this pregnancy that I could not explain without simply saying "it's just like having a human growing inside of you". A human whose face we have yet to see, yet who is in our minds constantly and we love deeply.
Now, we await the birth, which "should" happen at any point from next Tuesday, when she will be legally allowed to be born at home, until a month and a half away, the week 42 deadline for leaving my cozy belly. I'm hoping she makes her entrance soon, so that Jax, Mila and I have a bit of time to be together and adjust our schedules before the excitement of visiting family begins.
Below, a bunch of photos of the last few months in St. Augustine.
… read the rest...]]>
The doctor said two different names to describe each of the dog's condition, however the reason was the same – too much activity. He did … read the rest...]]>
The doctor said two different names to describe each of the dog's condition, however the reason was the same – too much activity. He did not warn us that the dogs might get this, if they ran around the farm. In fact he specifically said that they could just do their normal stuff. No intense jumping, etc. but basically, no limits. Unfortunately, he just really did not get what "normal" means for our pups living on the farm, despite us trying to explain how crazy-active they are to him quite a few times. This all lowers him a notch in my favorite vets book – which so far only contained him!
Anyway, the pups are in cage together, surrounded by a bunch of other caged dogs, so hopefully they are having a great time!…
It is not that I am a paranoid dog owner, because for the most part I am pretty relaxed about their daily activities. But the thought of having something always in the back of my mind seems like so much to handle. Oh well, the day will come some sooner or later and I'll have to deal with it – for now Yaku and Yana are excellent training. Especially this coming month, when we'll leave them for a month and a week!! Just kidding.
Anyway, Yana got her stitches with our amazing vet and she spent the rest of the day doing what we did not want her to do – jumping and fighting. She is now playing with her brother outside – hopefully tonight her stitches will stay attached and our night will go smoothly.
Now, three random blue photos
Today, I could not spoil the pups more! I gave them buttermilk after making butter, three bones, lots of food, milk, an … read the rest...]]>
Today, I could not spoil the pups more! I gave them buttermilk after making butter, three bones, lots of food, milk, an apple and pretty much anything else they lay their eyes on. I opened the door for them about 30 times, which stirred up a discussion with Jaxon about spoiling the pups. Which, he is totally right about – but again, he has never had surgery.
Tonight after a somewhat active day for both Yaku and Yana, were getting ready to head to bed. As usual, Yaku pushed the door open from the outside and when it was time to close it, both dogs hustled to be the first to jump up and push the door closed – the winner would get a dog cookie. Yana tried once, then Yaku, then Yana. Jax was standing next to them and I was looking at the three of them happy that the pups were being so active. The whole day they had being playing and jumping, so we didn't feel weird about having them close the door. On the third try I got a really bad feeling when I saw Yana turn around with eyes wide open.
I called her right away and saw that all her stitches had just pulled out. Yana looked at me, then at her stomach and started panicking, along with her Yaku. Jax grabbed her and I proceeded to call the emergency phone number on the vet's emergency card – no answer. I started to panic. I called my dad who, at 10:00pm, offered to come help – thanks a lot dad. But we needed to do something before he came. Yana was screaming and panicking every other minute, Yaku was barking, I was on the verge of a panic attack and Jax held Yana tight. While pacing back and forth, I tried to remember all my health classes and all my memories led me back to 11th grade Biology – CLOSE THE WOUND. I hurried to our medical kit, which only contained band-aids (Note: buy/make First Aid kit – Top priority)
After a bunch of screaming by Yana, my dad's calming dog-noises, Jaxon's strong grip and my nursing practices, we got her wound disenfected and covered with gauze. I am now sitting next to her, wondering if I should spent the night awake making sure she is okay. Jax just said goodnight to Yaku, downstairs and he is now crying – and me too.
How am I ever going to be able to handle this with my children? Did I mention that the cut is only 1.5 inches long and not bleeding.
None of this mattered today though, because Milton betrayed Yaku and Yana. I personally think Yana knew something was up, as she got pretty nervous when we put her on the operating table. Then again that may just be because she has finally built up an association between that table and having thermometers inserted in her bum. Anywhoo… In less time than it took for Caye to ask, "How long before the anesthetic takes effect?", Yana was flat on her face and out cold – or apparently just REALLY high according to Milton. That's where we left the two – with two huge rawhide bones for when they woke up and an extremely nice vet.
4 hours later, we picked up the puppies, who were super happy to see us, Yana even pee'ed herself with joy, and looking surprisingly good and considering they just had their reproductive capabilities removed. Unfortunately, the good humor was not too last. 1 hour after getting home and Yana was in a lot of pain. She looked totally miserable, could not sleep and just cried a bit every so often. Then, she got lost… seriously, just gone! We searched in every nearby building, field, pasture, hole, river, every corner of the house and all of her favorite places. Nowhere. After 30 minutes of searching and calling her name in vane, things were seeming pretty desperate, especially because there is a bit of history of dog theft here. Caye started tearing up and I was ready to hop in the car and start searching the village. Before that though, I decided to peek inside of an old collapsed out-house and their was Yana looking up at me, drugged and confused. Very "emotional" Caye came over, we extracted the pup and headed back to the house for some serious cuddling. And that's what we are still doing.
A lot of the photos are from today's two round-trips to Ibarra. The road there is gorgeous and I finally got over my stubbornness (again) and took Caye's very kind and constant advice to take photos while she drives. Have I mentioned that I am terrible at sharing cameras…?
In the last few days we … read the rest...]]>
In the last few days we have been noticing that our dogs are increasingly fearful of the tinniest dog ever. Her name is Princess, a tiny 3 month old Poodle, she is owned by the three year-old granddaughter of one of the guys who works at the horse shed. Princess, constantly appears squeaking from her yard, where she spends her days being another one of the little girl's doll. Everyday, Princess has another outfit, but the pink ribbons in her hears are always the same. Yana and Yaku used to find her weird at first, now they are just simply terrified of the miniature dog.
Okay, after listing every gross thing I have found within a half-day's worth of digging, I will tell you that after cleaning it, the spot will house some healthy grass, vegetables and a beautiful green house. Yesterday, Jax and I went to the hacienda's big vegetable garden to get some spice plants that will decorate our kitchen, bigger ones will be planted in our herb garden. We also got Taxo (a local fruit) and lavender seeds to plant along the entrance of La Casita. A two tomato branches sit in water as we speak growing some roots, we also got a huge chunk of growing strawberries to replant outside our little porch and a Cedrón (Lemon Verbena) branch is ready to replant also. This weekend, we plan to dedicate to our garden and maybe my mom and sister will come visit, which would be the garden's lucky day, because my mom has an amazing hand for plants.


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Having white teeth is a sign of good health, which is why you should inspect the mouths of horses you're going to buy or people you're going to kiss. Get a healthy grin with this Groupon.
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- $59.99 for a one-hour in-office teeth-whitening treatment (a $199 value)
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Lasting White Teeth
With multiple locations throughout the valley and mobile service available, Lasting White Teeth's specialists brighten smiles using laser-activated whitening gel. During appointments, they keep clients comfortable with protective eye goggles and vitamin E oil for keeping lips and gums hydrated throughout the whitening process. An enamel-booster treatment reduces sensitivity, maximizes results, and wards off cavities and gingivitis. Lasting White Teeth also offers a full line of aftercare products such as hydrogen peroxide whitening caviar, which clients can use to maintain their new and improved smile.
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West Sixth Brewing CompanyMarch 30, 2014Brewery • Lexington, United States
Awesome place with great people and good beer. Lemongrass wheat.. Don't think about it..Just DO IT!
University Life consumes me.
Awesome place with great people and good beer. Lemongrass wheat.. Don't think about it..Just DO IT!
Great movie.. The theater is a little sketch.. People were yelling at each other during the show.
Monday's only: get popcorn and a drink for only $2.50.
Best barbecue! If you are looking for pure and simple smokey pork and beef this is the place. Surprisingly tender and delicious!
There is a creepy guy named Daniel G. Who checks in to places without actually visiting them.
Best time to have tires installed is Sunday close to closing.. They will get you right in.
Wonderful place to learn about Denali National Park and Preserve.
Visit Base Camp Bistro for incredible food plus drinks made by Holly. You won't be disappointed!!
Hope your tour director is Camalama-Dingdong.
While you're here visit Fairbanks best gift shop!
First showing of the day is only 6.25!!
Fear the reaper! Aka Jenna!


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Who better to take you through the life of a Mt. Hood summer shredder than down-home Oregonian Dylan Thompson? Check out what MFM Family member does when he's not filming ender parts for snowboard movies. Or just watch with envy, from the comfort of your office chair, as someone who has a cooler job than you plays around in the woods and snow. Maybe next year you should think about spending some time up on the glacier?
Summer Shred: Dylan Thompson
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Wassim Hotel
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Hasta luega, España
... worth it! RAFAEL The morning, we wandered through the gorgeous rooms and gardens of the Alcazár, the interiors very well preserved and conveying a real sense of the luxury and sensuality of the past life of the palace. We also visited the immense Sevilla Cathedral, which contains the remains of Christopher Columbus and his son. I'm reading about him at the moment. In his quest for glory and wealth in the service of Ferdinand and Isabella of Spain, he sought the passage to ...
Romans and Arabs and Berbers (oh my)!
... with large banquette booths and the upholstery of each table was of a of different brocade design. The service was wonderful and we again started with Moroccan salads before being served lamb tajines and vegetable pastille for the vegetarians. We were so hungry that we descended upon the food and actually requested seconds of some of the salads, which was the first time we had finished a dish so far in Morocco. All the walking and the late hour of the dinner had helped ...
Not in Kansas Anymore
... The first 20 minutes were blissful: children calling me 'maîtresse' as I helped them learn the technique; boys excitedly choosing the colours of their favourite football club. One boy, Ayoub, was especially bright -- he quickly advanced beyond the basic bracelet and demonstrated impressive creative thinking. Suddenly, though, it all turned sour as older boys arrived and began pulling bracelets off the wrists of the young. ...
New "old town" - Fes el-Jedid
... el-Bali, through the peaceful garden - the 'jardin jnan sbil' into Fes el-Jedid. It took us over half an hour as we had to stop a few times to work out where we were. Once there, we made a 'mint tea' stop, then 'fell into' the tiny old synagogue as the entrance was quite obscure and if not for the fact that there was a sign over the door, we would not have known it was there. Like most of the buildings in Fes, one could climb up onto ...
... to join us for a time in our wanderings. We will travel another two weeks or so in Morocco, then to Spain for three or four weeks; my folks will fly home out of Barcelona and we will keep roaming around Europe until they throw us out. (In Europe, there is this thing called the Schengen territory, where you can only spend 90 days out of every 180 days if you are not from Europe. This means we have to be very careful about our timing and will leave a lot on ...


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Morris teacher seeks DFL endorsement in 12A
MORRIS, Minn. - Morris teacher and Early Childhood Program Coordinator Tamy Reese has announced her candidacy for the Minnesota House of Representatives in District 12A, seeking the DFL endorsement.
"I will represent the needs in our district," Reese said in her announcement. "I've been getting many positive responses from community leaders, who feel I can be a great voice for the citizens in rural Minnesota."
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Hiding Secrets With Steganography On FreeBSD 424
from the hiding-it-together dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
then you have to crack them
Of course.
These utilities usually use bits that will not make a change apparent to a human observing the data with our normal senses (ie. the last bit in each color field) so obviously doing anything to change the bit pattern will destroy the message.
The steghide info command is quite useful. It will tell me if a file contains hidden data (however, only from steghide-created files, as far as I know)
Now if we were going just by technical merits (or even moral merits) something like Apple should have died its righteous death a long time ago. But, I guess people need to worship on the altar of 'alternative', even if they are getting robbed blind for it. IMO, Apple is the worst monopolist ever (well, aside from someone truly attrocious like DeBeers).
No amount of careful planning will ever replace dumb luck.


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Today marks the 20th anniversary of the seminal kids' classic, The Little Rascals. To celebrate, it seems that the film's original cast got together and did their best to recreate the film's poster and most iconic moments.
We told you a few weeks ago what your favorite cast members from The Little Rascals were up to now, but it looks like the whole gang is now hanging out together once more. Blake McIver (Waldo) posted a photo of the entire cast recreating the film's poster on his twitter today and it like that's just the beginning! A little-known production company called 22 Vision wrangled all the "Rascals" up. They've posted more photos on their Facebook account.
'The Little Rascals' 20th Anniversary Reunion You've Been Waiting For
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Victoria's Secret models in multimillion dollar bras
Each year, Victoria's Secret reveals a new multimillion dollar fantasy bra to be worn on the runway in the annual Victoria's Secret Fashion Show. The 2013 bra, they announced Wednesday, is worth a whopping $10 million and will be worn by blonde bombshell Candice Swanepoel. Here, a look at fantasy bras through the years.
7 spring fashion trends you need in your wardrobe 17 amazing recipes for your Easter brunch One-tank casinos worth the drive 24 LI shelter cats looking for homes Krispy Kreme and 26 other chains LI wants 34 LI dogs you can adopt now Miranda Lambert, 83 other NYC weekend picks Travel gear and gadgets Good buys for foodies 12 social media pets you should be following 16 things you have to do this spring in NYC 10 must-see places to visit in 2015


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Sunrise Vanguard availability
embedded_timSeptember 24, 2012
Does Sunrise still make the Vanguard line of windows? All that I can see on the Sunrise website (http://www.sunrisewindows.com) is the standard Sunrise collection and the "essentials" collection.
When people reference Sunrise as one of the better premium vinyls here, are they referring to standard Sunrise windows or something else?


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Shane Carwin Talks Interim Titles, Defends Brock Lesnar and More
by Staff - December 10, 2009
- Shane Carwin was recently interviewed by bleacherreport.com, here are the highlights:
On Defending Brock Lesnar: I certainly think Brock gives the fans plenty to pick at when he is healthy and able to defend himself. Here is a guy who not only is so sick he can't fight, but he may never fight again. He has spent a lot of his life being a professional athlete, and then all of a sudden he is at risk of losing his ability to compete. I felt compelled to make sure that people knew I didn't feel that Brock was "ducking me" or any of the other crazy things that were being said. Brock is a warrior, and I do not see him ducking anyone.
On Fighting For An Interim Title: Titles are not important to me. The interim title is second place with a medal. I am already in that spot (the No. 1 contender spot), and I do not mind fighting to protect that spot, but I do not need a glorified trophy to do it. The champion is Brock, and he has the only belt that should matter to any fighter in the heavyweight division. I do not want to be the glorified contender, I want to be the guy that went in and fought the best guy in our division for the most prestigious prize in our sport. Until then, I am just another UFC heavyweight at the top of the division waiting for a fight.
On Being Disappointed In Fedor Signing With Strikeforce: Only because I would like to fight the guy. He is one of the best P4P in the world and as a heavyweight, he is the standard. If you are a true competitor you would want to face Fedor and test yourself against one of the greatest fighters of all time. Fedor could technically be considered undefeated: He has 30 fights and will go down as one of the legends of our sport. Strikeforce has a huge viewing audience, and they are willing to co-promote with M1. I suspect CBS will realize what they have in Fedor and will increase their marketing of him and Strikeforce.
On Not Fighting in Nine Months: Not really; we train hard at Grudge Training Center, and it's not like I am taking time off. The other way to see it is I have had to get ready for two different fighters over three training camps and how much that has improved my game?
On The Heavyweights From This year's Ultimate Fighter: They need to get that cardio up for sure. Guys like Cain Velasquez have unlimited gas tanks, and you do not want to gas against the UFC's elite heavyweights. I think some of those guys are going to be a force in the division, and I look forward to seeing them rise to the top.
|2015 WWE Hall of Fame Report: Kevin Nash, Randy Savage, Arnold Schwarzenegger, Connor Michalek, Others
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|Backstage News on Brock Lesnar Possibly Turning Babyface, How Serious His MMA Training Has Been, More
|Brock Lesnar on Why He's Staying with WWE, Vince McMahon's Offer at Last Night's RAW, More
|WWE Reportedly Planning The Undertaker's Retirement For WrestleMania 32
|Why WWE Is Really Concerned About Daniel Bryan's Future, Backstage Talk on His WrestleMania Role
|Roman Reigns Tell Twitter Critics To Stop Bullying Him


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Unichip on Ebay
I finally found my unichip but I noticed there was another guy looking for one too and here's one on ebay. it's for an FJ but they're the same as the ones on ours. They just need remapped.
anyway, long story short, here's the url:
is it seriously add 40 + sumtin HP to our car?
No, I couldn't possibly make that claim of 40 hp! So, as for the ad, take it for what it's worth, just someone who knows nada about the chip trying to sell it.
So if you already know what it is and know what it does, here's an ad on ebay. Also, I think the guy is asking way way too much for a used unichip. Try to make him an offer and tell him that one sold on there 2 weeks ago for 330... And I know it did because that's how much I paid for mine.
Anway, I've got mine installed and I can tell that it has more power, better throttle response and I finally broke 20mpg but I haven't dyno'd it so I don't know any exact numbers.
how do you dyno it? and wat's mpg now?
As for the dyno, I'd have to take it to a shop where they have a dyno machine and make a couple of test runs to get a baseline, then plug the chip in and see what the difference would be. There are shops that specialize deal the unichip and for a price, they'll dyno your rig and give you a specific map for the chip spec'd for your exact car, not just a basic generic map of you have an intake and an aftermarket exhaust.
For mpg, I can't give accurate numbers since I only have one tank of gas through it and I got a new exhaust at the same time. So, to say the least I've been enjoying the sound and power a little too much to see the mpg change too much. I will say that even with that, I broke the 20 mark when my old personal best was 19.2 driving very conservatively.
any other q's feel free to ask.
i have a unichip in my 04 tacoma and it gave me around 4 mpg better than i was getting before
|All times are GMT -7. The time now is 07:41 PM.


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Country Inn & Suites Traverse City, Traverse City
Situated in Traverse City, Country Inn & Suites Traverse City is close to The Dennos Museum Center, Bryant Park, and Traverse Area District Library. Also nearby are Traverse City State Park and Traverse City Beach.
Hotel Features.
Country Inn & Suites Traverse City has an indoor pool, a spa tub, and a fitness center. Complimentary wireless Internet access is available in public areas. There is a business center on site. Guests are served a complimentary breakfast each morning. Additional amenities include an elevator (lift) and express check-out. Self parking is complimentary. This is a smoke-free property.
Complimentary wireless high-speed Internet access is provided. All accommodations provide desks and safes; free local calls are offered (restrictions may apply).
Nice place for a quick stay. Breakfast was fine. Room was nice.
great service and nice updated room. If your looking for a hot time with your honey…get…
Enter dates to check prices
Hotel Info: 866-539-8117from $69
- Studio Suite, Non Smoking
- Studio Suite, Non Smoking
- Suite
- One Bedroom Suite
- Suite, Non Smoking
- Suite, Non-Smoking
- Suite, Non-Smoking
- Suite, Non Smoking
- One Queen Bed, Non-Smoking, Accessible
- Suite, 2 Bedrooms
- Suite, Non Smoking
- Standard Room, 1 Queen Bed
- Suite, 1 King or 1 Queen Bed
- Suite, Non Smoking
- Suite, Non-Smoking
- Guest Room, 1 Queen, Non-Smoking
- Suite, Non-Smoking
- Guest Room, 1 King, Non-Smoking
- Standard Room, 1 King Bed, Accessible
- Guest Room, 2 Queen, Non-Smoking
- Standard Room, 2 Queen Beds
- Suite, 2 Bedrooms, Smoking
- Double Room, 2 Double Beds
- Deluxe Room, 1 King Bed
- Two Queen Non Smoking Guest Room Microwave Fridge Free Wifi
- One Queen Non Smoking Single Queen Guest Room Microwave Frid
- One King Non Smoking Guest Room Microwave Fridge Free Wifi
- Double Room, Multiple Beds
- Standard Room, 1 Queen Bed, Accessible
- Suite, 2 Queen Beds
- Two Double And One Queen Murphy Bed
- One Queen Bed Non-Smoking Accessible
- Suite, 1 Queen Bed, Accessible, Non Smoking
- Standard Room, 2 Bedrooms
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel is arranged over 2 floors
- Check-in time starts at 4 PM
- Check-out time is 11 AM
- Express check-out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed
- Restrictions apply *
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
Other information
- Smoke-free property
Nearby Two Star Traverse City hotels
In the hotel
- Free hot/cold buffet breakfast daily
- Indoor pool
- Fitness facilities
- Spa tub
- Business center
- Conference space
- 24-hour front desk
- Elevator/lift
In the room
- Desk
- Free WiFi
- Free local calls
- Microwave
- In-room safe
Top Traverse City hotels
Nearby hotels
Country Inn & Suites Traverse City, Traverse City's small print
Also known as
- Traverse City Days Inn
- Days Inn Traverse City
- Days Inn Traverse City Traverse City
Guests with pets must contact the property in advance. Guests can contact the property using the number on the reservation confirmation received after booking.
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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I'm changing out a 200amp service to a 400amp service. This is out in the county and I not sure if the feeder wire from the transformer to the service mass needs to be changed out. I'm use to routine and not the "Bible."
- Forum >
- Electrical & Lighting >
- Service
It is usually the responsibility of the utility company to feed from the transformer to the service mast.
Yeah, they want an engineer out there. For what I don't know, they also said I need a master to be able to do that. My thought is that the less they know the better. They also charge you for pulling the meter. That a real incentive for people to go to the utility company. What I really need to do I guess is one of two things: Find a master that will work with me on this job or get of my lazy butt and look up wire sizing and pray I don't get caught.
It's residential, They have a boat house with three boat lifts about 300' from the service. They also are putting in a pool and they just built a shop for with lots of saws and compressors. They can have another meter, but they want that for the guest house and shop on. They want the boat house and pool on the same as the main house. The main house is all electric and the panel is too full and will be too overloaded to add all that.
What state are you in, I have a N.J.licence.
LOL . Sounds like a big job. Good luck with it, and don't undercharge.
LOL . Sounds like a big job. Good luck with it, and don't undercharge.
Jeez, with all the money those folks have for boats, boat lifts & boat houses, don't they have anything left over to hire a real electrician (I.E. one who is licensed, carries insurance, etc)?
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- 12 Places You Never Clean—But Should!


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August 7, 2013
After nine years of perfect attendance, Mary Rupp has retired as board secretary for the NCUA, the agency said Friday.
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