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Causality in Biology Has to Answer
2 Main Questions—Which and How
Letter to the Editor / Response
Dear Editor:
This letter is a response to the article ''The Systemic
Effects of Platelet-Rich Plasma Injection'' by Wasterlain
et al,7published in a recent issue of AJSM. Their experi-
mental analysis and subsequent conclusions concerning
the effects of intratendinous infiltration of platelet-rich
plasma (PRP) on systemic growth factors, as well as the pos-
sible role that such effects might play in the World Anti-
Doping Agency (WADA) assessment of athlete performance
enhancement, demands our critical participation in the dis-
cussion, particularly in light of the authors' claim that
theirs is the only adequately powered study of such systemic
effects. Although the protocol was carefully conducted and
aspects of the experimental design were exquisitely built,
there are nevertheless several issues that we believe require
more thorough reflection and more detailed explanation.
The authors establish a cause-effect relationship between
the intratendinous infiltration of PRP and the increases of cir-
culating levels of growth factors with performance-enhancing
potential. Moreover, to do so they attribute the activation of
the human growth hormone (hGH)–insulin-like growth factor
1 (IGF-1) axis as a biological pathway. Although the authors
report a low rise of IGF-1 plasma concentration (9%) and
state that ''a single PRP injection is not sufficient to maxi-
mally stimulate IGF-1 production,''7(p190)
granted that the axis is stimulated by PRP action. We should
not forget what the participants went through in the first 24
hours of the study, which may have strongly influenced the
hGH–IGF-1 activity and would therefore point to a quite dif-
ferent biological interpretation of cause and effect. The 25
patients who took part in the study underwent 4 blood with-
drawals that overlapped with PRP infiltration. Perhaps there
were 5 withdrawals;the authors were not clear whether a sin-
gle blood withdrawal was harnessed for both the baseline
growth factor levels and the PRP preparation or whether sep-
arate blood samples were used, an experimental issue that
has its own questions.
The first question is whether the baseline of hGH is a real
baseline. It seems that it would be useful to know these data
as well as the time of day when the blood samples were
obtained since we cannot assess the impact of the diurnal
cycle on the growth factor levels. The second question is
related to the observation that IGF-1 peaks 24 hours after
they take for
the PRP infiltration (shown in Figure 1 of the article) whereas
the value of IGF-1 after exogenous hGH administration
peaks at 36 to 96 hours.1,6This fact does not reflect an
hGH-mimicking action by PRP infiltration as the authors
claim. Third, the hGH level mainly illustrates (Figure 1A)
a rather biphasic profile response with 2 high points: one at
0.25 hours (16-fold) and another at 24 hours (12.7-fold) after
PRP infiltration and another lower peak at 3 hours
(4.7-fold) that, however, is higher than the baseline in
between. Since their claim rests on a single biological fact
that ''human growth hormone increased dramatically within
the first 24 hours after PRP treatment, as expected for
hGH–IGF-1 axis activation,''7(p188)and this is the reasoning
on which their conclusions are based, a more methodical
and biological justification is warranted. Indeed, 2 questions
arise: How could only 1 PRP infiltration influence the
hGH–IGF-1 axis by expressing its stimulation biphasically,
and which of the biomolecules that make up the PRP product
might be responsible for doing so? These questions give rise to
further considerations: If the gradient of growth factor con-
centration (shown in Table 2) between the PRP infiltrated
into the tendon and the bloodstream (serum or plasma) is pos-
itive only for growth factor content in platelets so that neither
hGH nor IGF-1 nor IGF binding protein–3 (IGFBP3) can dif-
fuse from tendon to blood, how could PRP stimulate the
hGH–IGF-1 axis? To date, we have not found any research
illustrating receptors to platelet-growth factors (basic fibro-
blast growth factor, vascular endothelial growth factor
[VEGF], platelet derived growth factor–BB) at the hypothala-
mus or pituitary gland that might support the authors' claim.
In addition, it is well known that tendon is a tissue character-
ized by poor vascularization, a fact that would add another
hurdle in the already difficult process of diffusion of biomole-
cules that make up the PRP product from tendon (where it
was injected) to the bloodstream, in a significant way. Fur-
thermore, the PRP activation within the tendon's collagen
and cited by Harrison et al2in 2011 gave rise to a more sus-
tained release of anabolic growth factors in a paracrine action;
however, it would not contribute to boosting the growth factor
tendon–blood gradient. And last but not least, this interpreta-
tion would give way to thinking that in every condition in
which a hematoma is brought about by a broken bone or
a muscle injury, some of the bioactive molecules of the hema-
toma would diffuse and trigger the hGH–IGF-1 axis and
even, in some severe hematomas, produce this effect steadily.
There is no warrant to invoke processes not yet known to be
generally applicable to problems such as the ones under
The American Journal of Sports Medicine, Vol. 41, No. 5
? 2013 The Author(s)
at STANFORD UNIV MEDICAL CENTER on May 13, 2013ajs.sagepub.comDownloaded from
Page 2
In a study conducted by Schippinger et al,510 young men
were treated with a single intramuscular application of leuko-
cyte-free PRP (autologous-conditioned plasma), which had no
effect on circulating IGF-1 values after 30 minutes (157 6
29 mg/L), 3 hours (159 6 25 mg/L), and 24 hours (161 6
38 mg/L). Moreover, the individual time courses of IGF-1
were essentially the same in all but 1 of the subjects.The mus-
cular tissue is highly vascular and therefore conducive to facil-
itating the tissue-blood diffusion, thus offering a suitable
scenario for PRP content to access the bloodstream and stim-
ulate the hGH–IGF-1 axis. However, the IGF-1 values at
24 hours after the intramuscular infiltration of PRP (161 6
38 mg/L) were not altered. In another study, 15 noncompeti-
tive male athletes were treated with subcutaneous injections
of hGH or a placebo for 14 days, and a significantly high level
of IGF-1 was noted after 72 hours of treatment.3In the report
by Kniess et al,3a study of the levels of IGF-13IGFBP3
showed a steady increase until day 7 of treatment, whereas
in the Wasterlain et al7study this parameter reached a pla-
teau at 3 hours after PRP infiltration.
In addition to these different biological responses
between the hGH administration and PRP infiltration in
the kinetics of IGF-1 and IGF-13IGFBP3, the intra-assay
coefficient of variation of the competitive IGF-1 assay
given by Kniess et al3was 8.8% at serum concentrations
of 149 mg/L, a value close to the 9% increase in IGF-1 (base-
line of 129 6 122 mg/L) shown in the Wasterlain et al7
study, in which the authors grounded their suggestion
that PRP treatment activates the hGH–IGF-1 pathway.
We agree with the authors that the specific methods
used to obtain PRP products significantly influence the
content of these preparations, mainly in these PRPs that
concentrate leukocytes, thereby rocketing both anabolic
and catabolic growth factor release. This methodological
fact may have a strong impact on the biological effects of
PRP in different tissues, a fact that should be taken into
account when using PRP as a regenerative approach.
More important, we consider that the inclusion of a con-
trol group (encompassing the same number of injections but
without infiltrating PRP) in the Wasterlain study might
have shed light on some of the questions raised in this let-
ter. The inclusion of such a group is an outstanding require-
infiltrations in a short period of time may have any systemic
effect. It is our modest opinion that the biological explana-
tions stemming from the results presented could very well
have been different had a placebo group (intratendinous
infiltration of placebo) been included in the design.
a repeatednumberof
Sabino Padilla, MD, PhD
Gorka Orive, PhD
Mikel Sa ´nchez, MD
Eduardo Anitua, MD, PhD
Vitoria, Spain
Address correspondence to Eduardo Anitua, MD, PhD (e-mail:
One or more of the authors has declared the following potential
conflict of interest or source of funding: Dr Anitua is the scientific
commercialized the PRGF-Endoret system. Drs Padilla, Orive, and
Sa ´nchez are researchers at BTI.
ofBiotechnology Institute(BTI),thecompany that
1. Blair JC, Camacho-Hubner C, Miraki Moud F, et al. Standard and low-
dose IGF-1 generation test and spontaneous growth hormone secre-
tion in children with idiopathic short stature. Clin Endocrinol (Oxf).
2. Harrison S, Vavken P, Kevy S, Jacobson M, Zurakowski D, Murray
MM. Platelet activation by collagen provides sustained release of ana-
bolic cytokines. Am J Sports Med. 2011;39(4):729-734.
3. Kniess A, Ziegler E, Kratzsch J, Thieme D, Mu ¨ller RK. Potential param-
eters for the detection of hGH doping. Anal Bioanal Chem.
4. Schippinger G, Fankhauser F, Oettl K, Spifk S, Domej W, Hofmann P.
Does single intramuscular application of autologous conditioned
plasma influence systemic circulating growth factors? J Sports Sci
Med. 2012;11:551-556.
5. Schippinger G, Oettl K, Fankhauser F, Spifk S, Domej W, Hofmann P.
Influence of intramuscular application of autologous conditioned
6. Spiliotis BE, Alexandrides TK, Karystianos C, et al. The insulin-like
growth factor-I (IGF-I) generation test as an indicator of growth hor-
mone status. Hormones (Athens). 2009;8(2):117-128.
7. Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL. The systemic
effectsofplatelet-rich plasma
IGF-1.JSportsSci Med.
Authors' Response:
We would like to thank Dr Eduardo Anitua and
colleagues for their response to our recent article.28
Dr Anitua's exceptional research has added considerably to
our understanding of platelet-rich plasma, and we agree
that our research needs to be discussed carefully. We would
also like to thank Andrew Hoffman, MD, an international
authority in insulin-like growth factors from Stanford
University, as well as Kevin Nead, MPhil, and Alex Sox-Har-
ris, PhD, notable statisticians from Cambridge and Stanford
University, respectively. Their contributions have been
invaluable in designing and executing our study and in care-
fully reviewing our manuscript and this correspondence to
ensure that our responses are accurate and in context.
This letter to the editor requests further methodological
details and raises 2 fundamental questions: Could local
PRP injection activate the hGH–IGF-1 axis, and if so,
what is the biological mechanism? It is important to note
from the beginning that our paper is an observational
report of systemic growth factor levels, and it does not
directly address the molecular mechanism underlying
these growth factor changes. The majority of the questions
raised in this letter are regarding our hypotheses of this
molecular mechanism. Although we are happy to discuss
these hypotheses in this forum, the molecular mechanism
needs to be directly tested through additional laboratory
studies. This discussion, however, should not distract the
reader from the main focus of the manuscript. The take-
home point of our investigation is that measurable sys-
temic changes in growth factor concentrations occur after
Vol. 41, No. 5, 2013 Letter to the EditorNP23
at STANFORD UNIV MEDICAL CENTER on May 13, 2013ajs.sagepub.comDownloaded from
Page 3
local, intratendinous PRP injection, and the mechanism for
this increase requires further study.
The first question posed is whether our hGH baseline levels
represent a true baseline. Our study was tightly controlled,
with baseline samples drawn in the morning for 21 partici-
pants (84%) and in the early afternoon for the remaining 4
participants (16%). To minimize trauma, a 16-gauge intrave-
nous catheter was placed contralateral to the tendon injury,
from which 30-60 mL of whole blood was drawn in a syringe
for the PRP, followed immediately by 2 separate BD vacu-
tainer tubes for baseline serum and plasma growth factor
analyses. Subsequent draws at 24, 48, 72, and 96 hours
were all done at exactly the same time of day as that individ-
ual's baseline draw, and participants were prohibited from
eating and exercising for 3 hours prior to each draw. How-
ever, it is widely known that hGH secretion is pulsatile and
is influenced by stress, exercise, caloric intake, patient sex,
age, and even time of day, making it difficult to compare
intra- and interindividual hGH levels.22Therefore, despite
careful attention to control for each of these factors in our
study design, we discourage drawing conclusions from our
hGH data alone. We reported our hGH data for completeness
and because hGH has been such an important target of anti-
doping campaigns over the past decade.
However, we do believe that our IGF-1 baseline levels
accurately represent the true baseline. IGF-1 secretion is
relatively stable with minimal intraindividual variability
over a 24-hour period, and IGF-1 levels are indicative of
integrated 24-hour hGH secretion3; specifically, the per-
centage change in IGF-1 (used in our study) has been val-
idated as an indirect assay for supraphysiological hGH.25
We agree that the stress of the PRP procedure could
affect circulating growth factor levels. However, human
studies have shown that stress actually decreases circulat-
ing IGF-1. For example, Dr Hoffman's group (Denti et al8)
showed that circulating IGF-1 was 32% lower in stroke
patients compared with healthy individuals. Other authors
have shown steady declines in circulating IGF-1 (25%) and
IGFBP-3 (27%) after elective surgery13and a 5-fold decrease
in IGF-1 after myocardial infarction.5These studies indicate
that stress is associated with an acute reduction in circulat-
ing IGF-1 and in the IGF-1/IGFBP-3 ratio, whereas we
found a significant rise in IGF-1 and an upward trend in
the IGF-1/IGFBP-3 ratio after PRP injection. This implies
that the rise in IGF-1 observed in our study occurred in
spite of (not because of) physical or psychological stress.
The authors also offer 2 reasons to question the impor-
tance of the 7% to 9% rise in IGF-1 reported in our study.
First, they suggest this could be within the margin of error,
since Kniess et al14reported a coefficient of variation (CV)
of 8.8%, which is roughly similar to the 7% to 9% rise we
reported. However, the CV is a property of each individual
assay and cannot be compared between studies; indeed, the
intra-assay coefficient of variation for the ELISA kit used
in our study was only 4.3%,20less than half that in the Kni-
ess study and substantially less than our measured change
in IGF-1. Additionally, our data at 24 and 48 hours
achieved statistical significance despite any variability in
our ELISA assays. Second, the authors of the letter refer
to a study by Schippinger et al23,24in which an intramus-
cular injection of 2.5 mL of autologous conditioned plasma
was given to 10 volunteers, in whom IGF-1 was not
increased at 30 minutes or 24 hours. Since this study
was powered to detect only large increases in IGF-1
(40%), smaller but potentially meaningful changes in
IGF-1 levels would therefore be missed. Second, statistical
analyses in the Schippinger study were conducted by com-
paring the mean IGF-1 level across all participants at
baseline to the group's mean level after PRP. Since IGF-1
levels were pooled into a single mean value at each time
point, this method fails to account for large variations in
growth factor levels between patients and may miss
changes in growth factors on the individual level. After
consulting with our collaborating statisticians and consid-
ering detection methods used by WADA, we used paired
t tests to compare each individual's baseline to his or her
own post-PRP growth factor levels. This method is now
an integral part of WADA's doping detection strategy,
known as the Athlete Biological Passport.29
Hypothesis 1: Stimulation of the hGH–IGF-1 Axis
In our article, we proposed that the increase in circulating
IGF-1 after local PRP injection could be due to activation of
the hGH–IGF-1 axis. We based this hypothesis on our
IGF-1 (not hGH) data. IGF-1 exerts anabolic effects on skele-
tal muscle and mediates the growth-promoting effects of
GH,15,18,26,27and IGF-1 is the most specific marker of supra-
physiological GH exposure.7We reported that circulating
IGF-1 began to rise within 3 hours after PRP injection,
increased significantly by 8% at 24 hours and by 7% at 48
hours, and remained elevated at 72 and 96 hours. Multiple
previous studies have shown that IGF-1 responds to hGH
within the same time window. Following a single hGH
dose, IGF-1 rose within 3 to 8 hours and then peaked around
24 hours.12,16Our results are consistent with these previous
reports, including the Blair et al4study cited by the authors
in their letter, in which IGF-1 peaked 36 hours after an
hGH dose.
Since the PRP itself contained less IGF-1 than serum at
baseline, the increase in circulating IGF-1 at 24 to 96 hours
cannot be from the PRP and must be from an endogenous
source. Endogenous IGF-1 is primarily synthesized by the
liver as part of the hGH–IGF-1 axis and acts in an endo-
crine fashion, although nearly every tissue synthesizes
IGF-1 in smaller quantities. Currently there is no test or
assay that can distinguish between IGF-1 synthesized by
the liver and IGF-1 synthesized elsewhere, so we cannot
determine the origin of IGF-1 secretion. One possibility is
that the observed rise in IGF-1 after PRP might be due
to simulation of the hGH–IGF-1 axis. We propose this in
part because we measured serum, not local IGF-1 levels
and because 75% of circulating IGF-1 is secreted by the
liver as part of the hGH–IGF-1 axis.30
The authors of the letter raise reasonable questions
regarding the mechanism by which PRP might activate
NP24Letter to the EditorThe American Journal of Sports Medicine
at STANFORD UNIV MEDICAL CENTER on May 13, 2013 ajs.sagepub.comDownloaded from
Page 4
the hGH–IGF-1 axis. The technique of PRP injection
involves penetrating the tendon, which may cause local
bleeding from the peritenon and could thereby provide
access to the bloodstream. PRP also triggers an inflamma-
tory response,2,9which indicates that PRP contents are
able to signal and recruit inflammatory cells from distant
locations. Furthermore, both IGF-1 and hGH receptors
are ubiquitously expressed, including within capillary
endothelium and in brain parenchyma,21
crosses the blood-brain barrier.19,21Although these path-
ways are not completely understood, these and other stud-
ies support possible mechanisms for molecules contained
within PRP to participate in hGH–IGF-1 axis stimulation.
and IGF-1
Hypothesis 2: Local Synthesis of IGF-1
Alternatively, one or more of the growth factors contained
within PRP might directly stimulate local production of addi-
tional growth factors. For example, since tenocytes express
the hGH receptor10and hGH has direct effects on most tis-
sues including stimulating IGF-1 synthesis,6,11it is possible
that the small amount of hGH contained within PRP binds
to tenocyte hGH receptors and stimulates IGF-1 synthesis,
ultimately contributing to a systemic rise in IGF-1. Evidence
regarding the ability of PRP to stimulate growth factor syn-
thesis in tenocytes is conflicting. Although one animal study
showed that intratendinous PRP injection enhances IGF-1
gene expression and protein synthesis in the epitenon and
Anitua's group1
VEGF but not IGF-1 production by human tenocytes in vitro.
In a transgenic mouse model, LeRoith's group (Yakar et al31)
showed that local tissue IGF-1 accounts for only 25% of the
total circulating IGF-1 pool. Therefore, it seems less likely
that local IGF-1 production alone could explain the 7% to
9% rise in circulating IGF-1. We propose that stimulation
of the hGH–IGF-1 axis is a more plausible explanation for
the systemic rise in IGF-1.
We agree that including a control group receiving intra-
tendinous saline injection or a true placebo group (sham
injection, but no tendon puncture) would be a useful next
step, although even a control group will not elucidate the
biological mechanisms discussed above. We also agree
that the magnitude of the response to a single intratendi-
nous PRP injection is clearly lower than the response to
multiple hGH injections, but this should not cause us to
deny that a response was observed. Our observation of sta-
tistically significant increases in multiple growth factors
over multiple days after local PRP treatment points to
a real systemic effect that cannot simply be ignored.
found that PRP induced
Amy S. Wasterlain, MD
Jason L. Dragoo, MD
Palo Alto, California
Address correspondence to Jason L. Dragoo, MD (e-mail:
The authors declared that they have no conflicts of interest in the
authorship and publication of this contribution.
1. Anitua E, Andia I, Sanchez M, et al. Autologous preparations rich in
growth factors promote proliferation and induce VEGF and HGF pro-
ductionby human tendon cells
2. Anitua E, Sanchez M, Zalduendo MM, et al. Fibroblastic response to
treatment with different preparations rich in growth factors. Cell Pro-
lif. 2009;42(2):162-170.
3. Barkan AL, Beitins IZ, Kelch RP. Plasma insulin-like growth factor-I/
somatomedin-C in acromegaly: correlation with the degree of growth
hormone hypersecretion. J Clin Endocrinol Metab. 1988;67(1):69-73.
4. Blair JC, Camacho-Hubner C, Miraki Moud F, et al. Standard and
low-dose IGF-I generation tests and spontaneous growth hormone
secretion in children with idiopathic short stature. Clin Endocrinol
(Oxf). 2004;60(2):163-168; discussion 161-162.
5. Conti E, Andreotti F, Sciahbasi A, et al. Markedly reduced insulin-like
growth factor-1 in the acute phase of myocardial infarction. J Am Coll
Cardiol. 2001;38(1):26-32.
6. D'Ercole AJ, Stiles AD, Underwood LE. Tissue concentrations of
somatomedin C: further evidence for multiple sites of synthesis and
paracrine or autocrine mechanisms of action. Proc Natl Acad Sci
7. Dall R, Longobardi S, Ehrnborg C, et al. The effect of four weeks of
supraphysiological growth hormone administration on the insulin-
like growth factor axis in women and men. GH-2000 Study Group.
J Clin Endocrinol Metab. 2000;85(11):4193-4200.
8. Denti L, Annoni V, Cattadori E, et al. Insulin-like growth factor 1 as
a predictor of ischemic stroke outcome in the elderly. Am J Med.
9. Dragoo JL, Braun HJ, Durham JL, et al. Comparison of the acute inflam-
matory response of two commercial platelet-rich plasma systems in
healthy rabbit tendons. Am J Sports Med. 2012;40(6):1274-1281.
10. Frick GP, Tai LR, Baumbach WR, Goodman HM. Tissue distribution,
turnover, and glycosylation of the long and short growth hormone
receptor isoforms in rat tissues. Endocrinology. 1998;139(6):2824-2830.
11. Gosteli-Peter MA, Winterhalter KH, Schmid C, et al. Expression and
regulation of insulin-like growth factor-I (IGF-I) and IGF-binding pro-
tein messenger ribonucleic acid levels in tissues of hypophysecto-
mized rats infused with IGF-I and growth hormone. Endocrinology.
12. Grant MB, Schmetz I, Russell B, et al. Changes in insulin-like growth
factors I and II and their binding protein after a single intramuscular
injection of growth hormone. J Clin Endocrinol Metab. 1986;
13. Hermansson M, Wickelgren RB, Hammarqvist F, et al. Measurement
of human growth hormone receptor messenger ribonucleic acid by
a quantitative polymerase chain reaction-based assay: demonstra-
tion of reduced expression after elective surgery. J Clin Endocrinol
Metab. 1997;82(2):421-428.
14. Kniess A, Ziegler E, Kratzsch J, Theime D, Mu ¨ller RK. Potential
parameters for the detection of hGH doping. Anal Bioanal Chem.
15. Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin
hypothesis: 2001. Endocr Rev. 2001;22(1):53-74.
16. Lee PD, Durham SK, Martinez V, et al. Kinetics of insulin-like growth
factor (IGF) and IGF-binding protein responses to a single dose of
growth hormone. J Clin Endocrinol Metab. 1997;82(7):2266-2274.
17. Lyras DN, Kazakos K, Agrogiannis G, et al. Experimental study of
tendon healing early phase: is IGF-1 expression influenced by plate-
let rich plasma gel? Orthop Traumatol Surg Res. 2010;96(4):381-387.
18. Mauras N, Haymond MW. Are the metabolic effects of GH and IGF-I
separable? Growth Horm IGF Res. 2005;15(1):19-27.
19. Pardridge WM. Transport of insulin-related peptides and glucose
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brain barrier. Endocrinology. 1994;135(5):1753-1761.
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22. Saugy M, Robinson N, Saudan C, et al. Human growth hormone dop-
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23. Schippinger G, Fankhauser F, Oettl K, et al. Does single intramus-
cular application of autologous conditioned plasma influence sys-
temic circulating growth factors? J Sports Sci Med. 2012;11:
24. Schippinger G, Oettl K, Fankhauser F, et al. Influence of intramuscu-
lar application of autologous conditioned plasma on systemic circu-
lating IGF-1. J Sports Sci Med. 2011;10:439-444.
25. Spiliotis BE, Alexandrides TK, Karystianos C, et al. The insulin-like
growth factor-I (IGF-I) generation test as an indicator of growth hor-
mone status. Hormones (Athens). 2009;8(2):117-128.
26. Velloso CP. Regulation of muscle mass by growth hormone and
IGF-I. Br J Pharmacol. 2008;154(3):557-568.
27. Walenkamp MJ, Wit JM. Genetic disorders in the GH IGF-I axis in
mouse and man. Eur J Endocrinol. 2007;157(suppl 1):S15-26.
28. Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL. The sys-
temic effects of platelet-rich plasma injection. Am J Sports Med.
29. World Anti-Doping Agency. Athlete biological passport: operating
guidelines and compilation of required elements. v 2.0; Montreal,
Canada: World Anti-Doping Agency. January 2010.
30. Wu Y, Sun H, Yakar S, LeRoith D. Elevated levels of insulin-like
growth factor (IGF)-I in serum rescue the severe growth retardation
of IGF-I null mice. Endocrinology. 2009;150(9):4395-4403.
31. Yakar S, Liu JL, Stannard B, et al. Normal growth and development in
the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci
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text:
Don't Screw Up Infected Space Elite For Your Whole Team!
View Single Post
Republic Veteran
Join Date: Jul 2012
Posts: 392
# 21
Originally Posted by
Granted, I don't have perfect experiance in STFs, but that whole "Only drop generators to 10%!" rule has NEVER worked for the bonus in all the times i've seen it used. it always ends with ppl taking too long, the spheres swarming the main generator, and them repairing it when we start attacking. (failing the mission)
I always vote to steamroll. Full power on the nanogenerators, take them down as quick as possible, then use someone as a decoy to distract the group of spheres coming from the gate while the rest take down the generator.
I've only had this plan fail once. (because someone was trying to do the 10% rule)
As opposed to using this plan and have it fail nine times out of 10,you need to be playing with people who "KNOW" how to play STO mate
Join date July 2012 ... My feckin arse ( Feb 2010 )
"The great thing about the internet is its leveling effect; online all opinions are equally WORTHLESS." <------> Grant Morrison

subset: commoncrawl


text:
Egypt votes to choose successor to Hosni Mubarak
CAIRO Faced with a choice between Hosni Mubarak's ex-prime minister and an Islamist candidate, Egyptians entered their latest round of elections in an atmosphere of suspicion, resignation and worry, voting in a presidential runoff that will mean the difference between installing a remnant of the old regime and bringing Islam into government.
The race between Ahmed Shafiq, a career air force officer like Mubarak, and the Muslim Brotherhood's Mohammed Morsi, a U.S.-trained engineer, has deeply divided the country, 16 months after a stunning uprising by millions forced the authoritarian Mubarak to step down after 29 years in office.
The two-day vote is taking place under the shadow of political dramas over the past week that effectively mean the military generals who took power after Mubarak's ouster will continue to rule despite promises to hand over authority to the elected president by July 1. The generals took over legislative powers after Egypt's highest court on Thursday ordered the dissolution of the parliament elected just six months ago, and the military made a de facto declaration of martial law.
As a result, few voters showed the sense of celebration visible in previous votes or confidence in the future. Among many, the mood was one of anxiety - whether bitterness that their "revolution" had stalled, fears that whoever wins protests will erupt, or deep suspicion that the political system was being manipulated. Moreover, there was a sense of voting fatigue. Egyptians have gone to the poll multiple times since Mubarak's fall on Feb. 11, 2011 - a referendum early last year, then three months of staggered, multi-round parliamentary elections that began in November, and the first round of presidential elections last month.
"People are depressed, no one is happy after we returned to square one," Abu Bakr Said, a lawyer and a Morsi supporter, said referring to Thursday's court ruling, which wiped out the only elected body in the country.
"We have no confidence now in any election and I know that a second revolution is coming," he said as he waited in line outside a Cairo polling center.
Some waiting in lines at polling stations said they were voting against a candidate as much as for a favorite. Anti-Shafiq voters said they wanted to stop a figure they fear will perpetuate Mubarak's regime; anti-Morsi voters feared he would hand the country over to Brotherhood domination to turn it into an Islamic state. With the fear of new authoritarianism in the future, some said they were choosing the one they believed would be easiest to eventually force out by protests.
Unlike in previous post-Mubarak voting when Egyptians were confident the balloting would be free, many this time round said they suspected the weekend's election may be tampered with.
"I don't think Shafiq could win, I think he will win," said Nagwan Gamal, a 26-year-old engineering lecturer at Cairo University who was voting for Morsi.
"I think there will be corruption to ensure that he wins, but I think a lot of people will vote for him," she said at a polling center in the Cairo district of Manial.


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All Articles Tagged "issa rae"
Issa Rae Is Writing A Book And Working On A New HBO Pilot!
Since the debut of her popular web series Awkward Black Girl, Issa Rae has been quite busy. Not only is she a host on new daytime TV talk show Exhale, but she's also working on a new pilot for HBO.
"I'm writing an HBO pilot. We just turned that in, so we're waiting on notes. And I'm always working on web series," she tells The Huffington Post.
In addition to all of that she's writing a book. Though she has yet to reveal specifically what the book is about, the actress/director did open up about how challenging writing a book has been.
"I'm writing a book right now — that is the bane of my existence because it is so freaking hard," said Issa.
Though many see the widespread popularity of Awkward Black Girl and believe her success came overnight, Issa says it's been a long time coming.
"It was a matter of good timing, but I was working towards it for awhile. In my current position, the third web series I did, ["Awkward Black Girl,"] happened to get a lot of attention but the first and the second were very slow."
She also discusses whether or not she feels responsible for helping other women in the workplace.
"Responsibility is a strong word. I just think there should be a natural desire. I don't feel a responsibility to, I just want to. I think that it makes [helping other women] almost undesirable if you have a sense of pressure associated with it. I just find it troubling when people try to put other women down. I don't think that's helpful in any way."
As for the "glass ceiling," Issa says she doesn't allow it to impact her.
"I choose to ignore it. I feel like by ignoring it, it doesn't really affect me. I've found that the people who acknowledge the glass ceiling feel affected by it and won't surpass it. I feel like more women are going the route where they're just like, "F it, I'm gonna make it happen for myself, whether you think it's gonna happen or not." That's my mentality."
Our girl is doing her thing!
Jazmine Denise is a celebrity news and entertainment blogger. Follow her on Twitter @jazminedenise.
Tags:authors, awkward black girl, books, career advice, goals, issa rae, media, writing
Issa Rae Set To Produce Andrea Lewis's New Web Series 'Black Actress'
From Black Voices
Our favorite 'Awkward Black Girl' Issa Rae is on a roll dishing out project after project. Not only is she working on an HBO series, and starring in a few webseries, she's also producing and curating content on her YouTube channel.
The latest project she's behind is entitled "Black Actress," and falls right in line with an issue that hits close to home for African-American actresses and creatives trying to make it in Hollywood. The webseries, created, written by and starring actress Andrea Lewis, features cameos and commentary from the likes of Tatyana Ali, Naturi Naughton, Essence Atkins, and Jenifer Lewis.
"My channel started off with 'Awkward Black Girl' but I always wanted to be a curator of great content, so when I saw "Black Actress" it was just like 'wow this story is hilarious.' I know so many women that have gone through this as an actress," said Rae.
The mockumentary style series centers around "Kori Bailey," played by Lewis, as she"struggles with the pursuit of getting her big break."
You may recognize Andrea Lewis from her role as "Hazel" on the hit show "Degrassi: The Next Generation." Since then, Lewis has appeared in guest and recurring roles on the Syfy network and CTV and is set to appear in BET's upcoming TV movie "A Very Larry Christmas."
"I grew up in the acting industry and I'd yet to have an experience on a set where I didn't feel like 'the black girl' whether it was the way a script was written or how the cast/producers/director interacted with me," Lewis said in an email to The Huffington Post.
Read more at BlackVoices.com
Issa Rae And Black & S*xy TV Team Up For Hilarious "Orange Is The New Black" Parody
Anyone who knows me personally knows that Orange is the New Black gives me a great amount of life, and I'm waiting very impatiently for season two. So when I heard about a parody of it done by the folks of Black & S*xy TV, I knew to expect something provocative and entertaining. Oh, and don't forget very funny, which is what the spoof is.
The parody, Orange is the New Black & S*xy, stars actress Jessa Zarubica as Piper, and Issa Rae as the always colorful Taystee. In it, Piper comes to prison, and though she's embraced by her fellow white female inmates, she becomes more enchanted with the black clique. By the end of the clip, she has a full Miley Cyrus makeover, has her inmate friends twerking, is trying to get her hands on some pig feet, and basically has a ball misappropriating black culture behind bars. The parody is a Dayna Lynne North/Loud Sista Production that was co-directed by Dennis Dortch and the uber-talented Numa Perrier. Check it our for yourself below and let us know what you think!
Seriously, Kanye Means More Than Arrogant: Celebrity Names That Have Deep Meanings
If you ask older men and women, too many people today name their children things that don't mean anything, and can barely be pronounced, but that's not necessarily always true. Some names are variations on classic names with meaning (i.e., Shaquille is a variation of the Arabic name Shakil, which means "handsome"), and some people's whose name just sounds cool can tell you its origins are more about God and promises for success from their parents, rather than just a catchy moniker. Here are a few famous folks whose names are more than they seem (and yes, you'll find many of the names to be African).
Sanaa Lathan
I know what you're thinking, Sanaa must mean gorgeous, because this actress is definitely a looker. But no, the name Sanaa is both of Swahili and of Arabic background. In Swahili, it means "brilliance," and in Arabic it means "art."
Issa Rae Wants To Show You What A Black Twitter Party Would Look Like In Real Life
2013 has been an interesting year for Black Twitter, an online of Black Twitter users. Not only was it given its own Wikipedia page, but Awkward Black Girl creator, Issa Rae, has gone ahead and created skit about what a Black Twitter Party would look like in real life.
The hilarious video titled, Black Twitter Party, features some of the major (and most annoying) personalities that you would encounter while navigating the cyber community. First we meet the boring girl, who tweets uninteresting and meaningless things like, "I love rainbows #colorful," and wonders why she can't retain followers. Next we meet the ever so annoying thirsty guy, who trolls around Twitter willing to sell his soul for followers.
Then of course, there's the outspoken intellectual with the cult following aka the amen corner and the infamous K.K.K. trolls. The video also hilariously depicts the wannabe Twitter comedian with the #youknowyou'reblackwhen jokes, the attention wh*re and of course, the pro baller. Last but not least, there's the too cool for school hipster chick who thinks she's seen, done and heard it all.
Turn the page to watch what happens when these personalities collide.
Issa Rae Offends Christians With Crips4Christ "Christ WALK" Song
A month ago we reported on Issa Rae producing a new web series called "The Choir" and in the latest episode, Issa debuted a new song she created called, "Christ WALK".
The song is a parody of rappers who find the Lord after committing heinous crimes. Although it will make you chuckle or at least crack a smile, some Christians did not appreciate Issa Rae taking Jesus and his living word so lightly. Some of the YouTube commentators stated:
Andrew Freed II – They spit in Jesus face 2013 years ago, and 2013 years later they haven't let up. Surprised?
Nia Johnson – Though this is quite disrespectful. Christian rap artist are nothing like this. Though this is for entertainment, could've been different .
Tim Verduin – God doesn't care a/b irreverent satires? Are you sure? "As obedient children, do not be conformed to the passions of your former ignorance, but as he who called you is holy, you also be holy in all your conduct, since it is written, "You shall be holy, for I am holy." 1 Peter 1:14-16 #truth #Bible #readwhatitsays
Other commentators argued Issa's song is a form of spiritual warfare, ignoring the fact that the song was satirical and shed light on rappers who have lived crime -ridden lives only to find themselves praising God at award shows or as they are dropping suspect bars. If anything, it depicted how people try to find balance between their personal and spiritual lives — only to appear hypocritical at times — or simply comical.
Check out the video below to hear "Christ WALK." Do you think Issa Rae is being offensive with the way she portrays Christianity?
Tags:christ walk, Christianity, Crips4Christ, Gospel Music, issa rae
From 'The Butler' To Issa Rae: 37 Ink Takes Book Publishing Around The World And Across Genres
Our special guest writer Ebony LaDelle wrote this story special for MN Business. You can check out Ebony's other stories for us here and here.
Though her walls are mostly empty, showing she's a fresh face in the Simon & Schuster building, her credentials certainly prove she's not new to the industry. It all started with one plane ride over 20 years ago when Dawn Davis sat next to a publisher who needed an assistant. Now, she's sitting at her mahogany desk excited about the possibilities of her new position as vice president and publisher of 37 INK.
37 INK is the newest imprint under The Atria Publishing Group (a subsidiary of Simon & Schuster), dedicated to bringing good books to hungry readers. The imprint will publish 10 titles a year from a variety of genres including literary fiction, narrative non-fiction, history, memoir and pop culture. "37 INK will publish authors from a diverse array of cultures and viewpoints," says Davis. "Our intent and commitment is to discover new talent, nourish authors, and affirm reading as a source of both entertainment and knowledge while supporting our authors with Atria's world-class marketing and publicity."
The first book from the imprint is The Butler, a companion guide to the movie starring Forrest Whitaker, Oprah, and Robin Williams. Written by journalist Wil Haygood and already a New York Times bestseller, The Butler goes in-depth about Haygood's journey to find Eugene Allen, a man who served eight presidential terms as the White House butler. His article, "A Butler Well Served by This Election," was published in the Washington Post on November 7, 2008 and was the inspiration behind the movie.
Davis drew inspiration for 37 INK from the 37th parallel north that runs across California, Africa, and Italy, all playing a geographic significance in her life. "Italy is where my grandmother came from. Africa is where we're all from. And California is where I'm from," Davis said. "There's so much fluidity in the world. We should read across all cultures; we're all a hybrid."
Next 37 INK will publish the e-book to 12 Years a Slave, a memoir about Solomon Northup, a free man from the north who was kidnapped and sold into slavery. The film adaptation will star Chiwetel Ejiofor, Quvenzhané Wallis, Alfre Woodard, and Brad Pitt. Already receiving Oscar buzz, the film will open in the States at the end of this year.
"I want to publish good books that the average, busy person can lose themselves in," said Davis. "I want to publish literary books in a commercial way."
37 INK aims to bring new voices to the floor, but Davis feels that's also the goal of every publisher. So in addition to introducing new authors, Davis wants to go after some of her own ideas.
"Either it's a literary trend, or you find someone that has a voice and a point of view. I like to work in both ways. If [someone has a platform] that fits the format of the book I'd like to collaborate," she said. For example, Davis recently acquired a book of hilarious essays by "The Misadventures of Awkward Black Girl" creator Issa Rae. Rae's web series has a huge fan following with over 20 million views.
The end goal, however, is to create literary books that are inspirational and soul-stirring. "I like to find things that are unexpectedly moving, like The Butler. He's kind of an every man who shows up and makes in difference in his own small way," said Davis. "Inner gems that speak a broader truth."
Ebony LaDelle works in marketing at Simon & Schuster, specializing in the education & library space, as well as an advocate of literature of color. You can connect with her on Linkedin (http://www.linkedin.com/in/ebonyladelle).
Tags:12 Years A Slave, 37 Ink, book publishing, issa rae, The Butler
Starting Out Young: These Entrepreneurs Have Built Businesses Before The Age Of 30
Being an entrepreneur isn't easy and definitely doesn't happen overnight. It takes a special someone to realize that they aren't cut out for the ordinary nine-to-five. And some people realize it early in.
In recent years, entrepreneurship has skyrocketed. Let's meet some entrepreneurs under the age of 30, who have threw up the peace sign to the nine to five and are already making their marks in the business world.
Black Women Telling Black Stories: Female Indie Filmmakers To Watch And Support
Are you looking for the silverscreen to give you more heroes/heroines of color? More stories about the black experience in America and not a whitewashed version of how we think and act? I know I am.
Black America has been conditioned to take what few images we can get of ourselves when it comes to entertainment. While we've had our onscreen triumphs outside of being portrayed as maids, thugs and wh*res – there is still an empty, canyon-like space where the broader range of our stories could and should be told. Well, black independent filmmakers are slowly but surely filling that space through Kickstarter campaigns and grassroots fundraising for the projects Hollywood repeatedly dismisses as irrelevant and unimportant.
The great news is that we don't have to sit and wait for "somebody" to do "something." These filmmakers are putting in the work and turning out stellar projects for our viewing pleasure, discussion and social action. And one of the greatest things about this indie movement is that many of these artists are accomplished black women.
With growing YouTube channels, film festival award-winning projects, Oscar-nominated films – there are a host of black women filmmakers who are working their gifts and talents to ensure that the span of black experiences are brought to screen in truth.
Here are six indie filmmakers/producers that you should keep your eyes open for.
Sadness: ABC Doesn't Pick Up Issa Rae And Shonda Rhimes' "I Hate L.A. Dudes" Series
From HelloBeautiful
Last year, fans of up-and-coming filmmaker Issa Rae and "Scandal" creator Shonda Rhimes were excited to find out that ABC bought the rights to their developing comedy series, "I Hate LA Dudes."
The show was expected to follow the life of an aspiring journalist who struggled to navigate the L.A. dating scene after a recent move to the West Coast. However, the project, which Rhimes hoped would be the first comedy for her Shondaland production company, will not make it to our TV screens this season.
Hello Beautiful caught up with Issa Rae at the Los Angeles viewing of her latest web series "The Choir," and she revealed that ABC passed on what would've been her first break into network television.
"ABC passed on ["I Hate LA Dudes"] so I am working on another series right now," she said. "But the process of working with [Shonda Rhimes] was freaking amazing and I learned so much from her." The mastermind behind the popular web series "Misadventures of Awkward Black Girl" said she's setting her sights on cable TV now. "That was network television; this one is kind of different" she said, describing the new comedy project she's co-writing and co-executive producing for HBO. "Cable, that's my home."
Read more at HelloBeautiful.com


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from Science News
Scientists have trained paralyzed rats to walk, run and even climb stairs. Weeks of rigorous practice coupled with an electrochemical spine-stimulating regimen allowed the animals to overcome devastating spinal cord injuries that immobilized their rear legs, Swiss scientists report in the June 1 Science.
Although preliminary, the results offer hope to people paralyzed by spinal cord injuries. "The really exciting thing, the take-home message for people living with spinal cord injuries, is that this represents yet another step towards real treatment," says neurologist John McDonald of the Kennedy Krieger Institute in Baltimore and the Johns Hopkins University School of Medicine. "The real beauty is that this is not something that would necessarily have to go through 10 years of FDA approval."
Recovery, the Swiss team found, relied on a combination of treatments, all readily adaptable to humans: Nerve cells in the spine below the damaged site were stimulated with a cocktail of drugs similar to some antidepressants. Electrical shocks, delivered via electrodes, also activated the spine. In this way, the researchers primed the rats for the next stage of treatment--learning to walk again.
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Smallhythe Place
Theatre in 2015
We're putting together an exciting theatre programme for 2015, in which you'll be able to see some regulars returning to Smallhythe as well as some new faces performing in the barn.
One slight change for the new year is the timings of our shows, most of the performances will now start at 7.30pm, instead of the previous 7pm; however please double check the timings of the shows on the event listings and the booking info. Be sure to keep an eye on the website for updates on our theatre events, all of which will be listed below in due course.


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Pop-up Events
We need volunteers to help with all our special events!
Plan your visit
Information about hours, parking, admission and accessibility.
You never know what you will get at the Children's Museum of Denver!
There are always amazing last minute surprises, fun events and guests coming to visit!
Check out photos from past Pop-up Events.
StoryTime with Alliance Francaise de Denver
Monday, April 13 at 11:30 p.m.
Friday, May 8 at 2:30 p.m.
Instructors from Alliance Française de Denver will engage little ones with a song, story and hands-on activity, all based on French language and culture. It's a "magnifique" StoryTime with French flair!
Activities included with general Museum admission.
Ready, Set, Rock
Saturday, April 11 at 3:30 p.m.
Sing along, dance around and shake it out during this interactive musical performance!
Activities included with Museum admission
Kids' Yoga Adventure
Thursday, April 30 - 10 and 11 a.m.
These 30-minute yoga classes are designed to show children how to use yoga to harness their energy and playfulness in creative and calming ways. Kids will learn yoga poses and breathing techniques that relax the mind, energize the body and allow them to have fun together. Wear comfortable clothes that you can move in and a playful attitude!
Activities included with general Museum admission.
Free visit to History Colorado Center for Children's Museum members
Monday, May 11 - Friday, May 29
Children's Museum members are invited to take a ride in a Model T, leap off a ski jump and mine for riches deep inside a mountain for free at History Colorado Center! Just show your Children's Museum of Denver membership card at the front desk of the History Colorado Center and you'll receive free admission for up to two adults and two children!
Learn more about History Colorado Center.
FutureVet with Banfield Pet Hospital
Saturday, May 16
Saturday, June 20
Saturday, August 15
Saturday, November 7
Saturday, December 12
11 a.m.
A licensed veterinarian from Banfield Pet Hospital will share their expertise about the exciting world of veterinary medicine, including what it means to be a responsible pet owner and what doctors look for when they examine your pets. Children will receive a diploma, stethoscope and goodie bag during "graduation."
Space and supplies limited. Activities included with general Museum admission.
Monday, May 18 - 9 a.m. - 2 p.m.
Grow your child's love of books and reading at Bookworms! It's a day of activities and learning designed just for children newborn to five and their adults.
Activities included with general Museum admission.
Members-only Morning
Saturday, June 13, 8-10 a.m.
During this two hour event, Children's Museum members are invited to be one of the first to tour Joy Park, our brand new 30,000 sq ft outdoor adventure space! Members-only Mornings include exclusive private play throughout the whole Museum, plus a 20% discount in the gift shop and cafe on purchases of $5 or more.
No RSVP required. Please present your membership card at the front desk upon arrival.
Swallow Hill Music Lessons and Fun
Ukulele Sing & Strum-a-Longs at the Children's Museum of Denver will have your whole family will be playing a tune in just 30 minutes.
Wednesday evenings
5-5:30 p.m.
All Swallow Hill Music activities are included with general Museum admission.
Find this on the calendar.
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By the way, been using SBH50 for more than a month now have no problem recommending this device to anyone looking for a wireless Bluetooth option for cellular or audio listening needs I'm definitely impressed with its functionality and sound quality. However the battery charge do not last more than two days even without use at all (standby only) and less than one day with light use (about one hour calls) although sony says that SBH50 minimum Rated Talk Time: 8 hours, and Minimum Rated Standby Time: 400 hours
I don't know if it is my Headset problem or it is actual battery life for this type of sony headset ??


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"Church Prophet Elias" Yaroslavskaya Oblast' by jorgejuansanchez
Yaroslavskaya Oblast' Travel Guide: 246 reviews and 500 photos
The first visit that I made in Yaroslavl, a Golden Ring city of about 600.000 persons, included in the UNESCO list under Patrimonies of the Humankind, was to the Kremlin, in the centre of the town. It was not free of charge and therefore I bought a ticket (it was very cheap: less than one euro) in a kiosk at he entrance. Then I went inside to admire the religious buildings and the architecture. In its premises there were several wooden miniatures representing the building within the Kremlin premises. That visit was a good introduction to the many wonders that shelters Yaroslavl.
Once inside I walked following the perimeter of the Kremlin and saw a sign saying that Yaroslavl was founded in the year 1010 by the Tsar Yaroslavl the Wise, and they are preparing great celebrations for the millennium in the year 2010.
Yaroslavl is located at the intersection of the rivers Kotorosi and Volga, which I visited, and discovered new churches and monasteries close to the river. Indeed, Yaroslavl is deservedly compared with Florence, in Italy. At every step you find a nice church, in the next corner you see a monastery, then pretty old buildings, etc. Yaroslavl is rich in culture and beauty.
When I was hungry I went to the pedestrian street to eat Russian homemade food in a stolovaya (local restaurant), which was cheap and delicious (I ordered "pelmenie", or a kind of Russian ravioli, and a drink called "medovukha") and then I visited the tourist attraction numero uno: the incredible Church devoted to the Prophet Elias, the first church constructed in Yaroslavl in the XVII century, when it was the capital of Russia during the Polish invasion of the country. The entrance was not terrific; it was just another nice religious building like many others in Yaroslavl. But once inside….. Madre mía! Inside, the frescoes and paintings of its walls, ceilings and columns was no less interesting that the Cappella Sistina in Rome. That was really a marvel among marvels that captivated me for a couple of hours that I spent inside, completely delighted, exulted, admiring one by one the delicacy and exquisite details of each fresco.
It is a miracle that the criminal Bolsheviks did not destroy the churches and monasteries in Yaroslavl (in especial that startling Church of the Prophet Elias), as they had done in most of the other Russian cities. Local people with whom I made friendship inside the Kremlin, told me that in the list of the destruction of religious buildings, the Bolsheviks had a list of the places in alphabetical order, and since Yaroslavl start with the letter "Ya" (Ia in Russian) and that letter is the last one in Russian alphabet, they had so many churches to demolish that they never arrived until the end, and in that way Yaroslavl religious wonders were saved.
In the evening, when writing my diary, I felt so happy to have visited such a 1001 night's city as Yaroslavl!
After writing my diary while drinking a couple of beers (Baltika 7), I bought a night train ticket to Ryazan.
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This is the first in a series, inspired by the work of Richard Misrach.
It was shot from 4 PM to around 5:30 PM on March 1, 2009, and brings to light the many air currents that interact with each other in complex ways.
The original digital sources are over 3K wide and the move was created after the fact, in After Effects.
Here is a link to Richard's book, GOLDEN GATE, a sublime photographic study of a remarkable spot on earth.
I found it amazing that he could create a series of images around one of the most photographed of human created structures and show it in context of the majesty of the sky - in a composition that makes it new, airy and light.
"Tching prayed on the mountain and wrote MAKE IT NEW on his bath tub. Day by day, make it new, cut underbrush, pile the logs, keep it growing" -Ezra Pound
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text:
Originally written on Fox Sports | Last updated 11/19/14
Martin Brodeur stopped 23 shots for his 121st career shutout to keep New Jersey's slim playoff hopes alive with a 3-0 win over the Philadelphia Flyers on Thursday night. Ryan Carter, Matt D'Agostini and Adam Henrique scored goals to help the Devils snap their 10 game winless streak (0-6-4). The Devils entered the game eight points out of the eighth and final playoff spot in the Eastern Conference. They have five games left and need a lot of help to even think about a postseason berth. For one more night, at least, the Devils still have hope. Brodeur wasn't seriously tested all game but did enough to earn his second shutout of the season. He got his 11th career shutout vs. the Flyers. Neither team came out playing with the passion expected in a game badly needed to keep even a scant chance at playing for the Stanley Cup alive. The teams combined for six shots in the first 12 minutes of a plodding first period. The Devils broke through in the second period when Carter's wrister b...
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Vedema Resort
Within easy reach of the beach, Vedema Resort is in Santorini (Megalochori), close to Gavalas Vineyard, Boutari Winery, and Antoniou Winery. Also nearby are Athinios Port and Wine Museum Santorini Island.
Hotel Features.
Vedema Resort has a full-service spa, an outdoor pool, and a health club. Complimentary wireless Internet access is available in public areas. This 5-star hotel features business amenities including a 24-hour business center, a meeting room, and limo/town car service. The hotel offers 3 restaurants along with a coffee shop/café and a poolside bar. Guests are served a complimentary breakfast. Additional amenities include a spa tub, spa services, and a steam room. Guests receive complimentary transportation including a roundtrip airport shuttle (available on request) and a ferry terminal shuttle. Complimentary self parking is available onsite for guests.
Rooms open to patios. The 45 air-conditioned guestrooms at Vedema Resort include minibars and safes. Guests can use the in-room complimentary wireless high-speed Internet access. Televisions are equipped with satellite channels. Bathrooms offer bathrobes, designer toiletries, hair dryers, and slippers. All units have kitchenettes. In addition, amenities available on request include in-room massages, irons/ironing boards, and hypo-allergenic bedding. Turndown service is offered nightly and housekeeping is available daily.
The rooms were exactly as advertised and beautifully maintained. Breakfast was perfect…
The hotel and surrounding town are charming. It was very relaxing and a good location to…
Enter dates to check prices
Hotel Info: 01 65 69 441from €309
- Suite (Aegean)
- Presidential Villa
- Villa (Olympian)
- Suite (Athenian)
- Suite (Dorian)
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 45 rooms
- This hotel is arranged over 2 floors
- Check-in time starts at 3 PM
- Check-out time is noon
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Babysitting/childcare *
- Pets allowed (dogs and cats only) *
- Restrictions apply *
- 1 per room (up to 5 kg)
Extra people
- Rollaway beds available, charges may apply*
- Free WiFi in public areas
- Free WiFi in rooms
- Free airport shuttle (available on request) *
- Free ferry terminal shuttle *
- Free self parking
Nearby Five Star Thira hotels
In the hotel
- In-room childcare (surcharge)
- Free breakfast
- 3 restaurants
- Coffee shop/café
- Poolside bar
- 24-hour room service
- Barbeque grills
- Outdoor pool
- Health club
- Full-service spa
- Spa treatment room(s)
- Spa tub
- Steam room
- Sauna
- 24-hour business center
- One meeting room
- 24-hour front desk
- Limo or Town Car service available
- Dry cleaning/laundry service
- Laundry facilities
- Wedding services
- Year Built 1992
- Safe-deposit box at front desk
- Picnic area
- Fireplace in lobby
In the room
- Air conditioning
- Minibar
- Bathrobes
- Slippers
- Iron/ironing board (on request)
- Hypo-allergenic bedding available
- Turndown service
- Sofa bed
- In-room massage available
- Separate sitting area
- Patio
- Private bathroom
- Designer toiletries
- Hair dryer
- Satellite TV channels
- Free newspaper
- Free WiFi
- Kitchenette
- Daily housekeeping
- In-room safe
- Connecting/adjoining rooms available
Recently reviewed hotels in Thira
- Aroma SuitesFrom
"The Hotel location is very central as it is right across the Bus & Taxi Station in Fira. However, do note that the room is quite small. The view from the room is the best you can…"Feb 10, 2015
- Golden StarFrom
"Golden Star is our preferred choice for Santorini visits! Nice short walk to Fira, beautiful views of the Aegean, super clean. The best part are Manos and Katerina, the hotel…"Jan 8, 2015
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- Armeni Village Rooms & SuitesFrom
"great location, right at the main area. nice views of the caledera. breakfast served in the room. around 50 steps only to the room from the main road."Oct 22, 2014
Nearby hotels
Special features
The onsite spa has 2 treatment rooms including rooms for couples. Services include massages, facials, body wraps, and body scrubs. The spa is equipped with a sauna and Turkish bath/hammam. A variety of treatment therapies are provided, including aromatherapy and hydrotherapy.
DiningALATI - This restaurant specializes in seafood and serves dinner only.
Pergola Pool Restaurant - This restaurant serves breakfast, lunch, and light fare. Guests can enjoy drinks at the bar.
Secret Wine Cave - This restaurant specializes in Mediterranean cuisine and serves lunch and dinner. Guests can enjoy drinks at the bar. Reservations are required.
On Site
- Health club
- Sauna
- Spa tub
- Steam room
- Bicycle rentals on site
- Personal motorized watercraft on site
- Scooter/moped rentals on site
- Yoga classes/instruction on site
- Hiking/biking trails nearby
- Mountain biking nearby
- Parasailing nearby
- Sailing nearby
- Scuba diving nearby
- Skydiving nearby
- Surfing/boogie boarding nearby
- Water skiing nearby
- Windsurfing nearby
Vedema Resort's small print
Cash transactions at this property cannot exceed EUR 1500, due to national regulations. For further details, please contact the property using information in the booking confirmation.
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
This property does not have elevators.
For transfers, guests must contact the property before arrival at the number on the booking confirmation.
Reservations are required for massage services and spa treatments and can be made by contacting the property before arrival at the number on the booking confirmation.
Mandatory fees
Pet deposit: EUR 50 per night
Optional extras
Rollaway beds are available for EUR 100 per night
Pets are allowed for an extra charge of EUR 50 per accommodation, per night (maximum EUR 50 per stay)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
MHTE number (issued by the Greek Tourism Organisation): 1144K035A0175500


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Editorial: Obama has had success in last month
Slice it however your political proclivities mandate, but there is little doubt President Barack Obama had a very good run in December. He won all but one of his legislative priorities, and that one, the DREAM Act, was not high on his list and really never had a chance of passing the U.S. Senate.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at email@example.com and we can help you.


text:
Release Date:
October 1, 1994
Date Published:
October 1, 1994
Elaborate fantasy scenes contain a variety of hidden objects and words.
Readers can hunt for hidden objects in colorful, cluttered photographs of such "fantasy settings" as sand castles, cities made entirely of building blocks, and a space station made of kitchen gadgets.
- Genre: Juvenile Nonfiction
- Subgenre: Games + Activities / Puzzles
- Age: 4-8 years
- Language: English
- Author: Jean Marzollo , Walter Wick
other Info.
- Online Item #: 11959899
- Store Item Number (DPCI): 248-29-3652
- Item can be gift wrapped.
- Made in the USA or Imported


text:
Mission Statement
We, the Parish of Saint Gregory the Great Catholic Church, are an integral part of the Catholic Diocese of Richmond. We proclaim God's love and the Good News of Jesus Christ to all by embracing the Church's Sacred Scriptures and teachings.
We are committed to strengthening our Mission of Service by encouraging stewardship centered on ways to better serve our parish and community as set forth in the themes of Catholic Social Teachings. We believe our faith is expressed by our diversity, inclusiveness and commitment to serve others. We encourage all to join in our Community by participating in our worship and volunteering to share their time, God-given gifts, and talents.
Holy Week and Easter
2015 Schedule
Mon., March 30 at 11:00 a.m. & 6:30 p.m
Wed., April 1 at 6:30 p.m.
No Confessions during the "Triduum"
HOLY THURSDAY: April 2
Mass of the Lord's Supper at 7 p.m.
(NO 6:30 or 8:30 morning masses)
GOOD FRIDAY: April 3
Liturgy of the Word and Veneration of the Cross
12 N and 3 p.m.
Tenebrae at 7 p.m.
(NO 6:30 or 8:30 morning masses)
Viernes Santo: 3 de abril
Veneración de la Cruz (en español) 8:30 p.m.
Regular Sunday Mass Schedule
6:00 pm (Vigil) & 7:30 pm (in Spanish)
7:00 am, 9:00 am, 11:00 am, 12:45 pm & 6:00 pm
Misa dominical en español: sábados - 7:30 pm
- 1st Friday of the Month 6:30 pm Mass:
May 1, 2015
on Fridays at 6:30 pm
Readings for Holy Week
March 29 through April 5, 2015
for Today's Reading ►
◄ for today's meditation.
Lecturas del Día || Daily Readings - Audio
Palm Sunday of the Passion of the Lord
|At the Procession with Palms:
|Mk 11:1-10 or Jn 12:12-16
At the Mass:
First Reading:
Responsorial Psalm:
Second Reading:
Is 50:4-7
Ps 22
Phil 2:6-11
Mk 14:1—15:47 or 15:1-39
Upcoming Events
YOU ARE CORDIALLY INVITED! to attend a Parish Gathering to learn more about the Living Our Mission Campaign to benefit St. Gregory the Great Parish and the Diocese of Richmond. Read more...
LENTEN EVENTS: Stations of the Cross, reconciliation, anointing of the sick, First Friday, etc.., Click here...
4TH ANNUAL BOOK GIVE AWAY: This year's book is "The One Thing" by Matthew Kelly. Read more...
CHECK OUT the New Evangelization page...
View the BULLETIN for more events, click here.
Schedules & Forms
- Altar Server
- Holy Week Schedule (includes Holy Thursday through Easter)
- April 2015 Schedule (includes Easter and the other 3 Sunday's in April)
- Lectors & Eucharistic Ministers Schedule
- February 15, 2015 to April 12, 2015
- Hymn Schedule
- February 8, 2015 to March 22, 2015
- Itinerario de Ministros y Monaguillos
- Misa en Español / Spanish Mass Schedule
Links to other Pages & Sites
- Electronic Giving
- Book Store
- Friday Night Bingo
- St. Gregory the Great School
- Bishop Sullivan Catholic High
- Catholic Diocese of Richmond
- Hampton Roads Catholic Schools
- St. Benedict's Chapel
- Saint Vincent Archabbey
- The Monks of St. Vincent Archabbey
- Sisters, Servants of the Immaculate Heart of Mary
- The Holy See | Vatican | Pope Francis
- News.VA Official Vatican Network
- U.S. Conference of Catholic Bishops
- Virginia Catholic Conference
- VIRTUS Online
- Follow us on


text:
Youth lacrosse tourney inspired by LLWS Miami Formula E exec plans for 2016 Sports Business Awards nominees Fox takes over Vegas hoops tourneys Formula E expects sellout at U.S. debut From the Daytona 500: News and notes D-II event is sponsor destination Gambling a key topic at All-Star Linking startups with sports, capital Legacy expands fan fest at Cactus League
Upcoming Conferences and Events
SBJ/May 7-13, 2012/Events and Attractions
McD's, A-B ready to Rock 'n' Roll
Published May 7, 2012, Page 8
|Both sponsors will activate at the Rock 'n' Roll Marathon in San Diego.
According to a Competitor representative, McDonald's will activate its single-year deal at races in San Diego, Denver, Seattle, Philadelphia and Chicago.
Anheuser-Busch will activate its multiyear deal at all 24 U.S. Rock 'n' Roll races, with an inflatable dome, sampling and a branded concert stage, and with signage at local distributors. A-B also will place kiosks near the finish line where participants can upload photos to social media.
"We're at a tipping point with endurance sports gaining non-endemic interest," said Scott Dickey, CEO for the Competitor Group. "The big boys are starting to take note of who we are."
The two deals follow a busy period of renewals and new signings for Competitor, which this year added four U.S. races and two international events to the Rock 'n' Roll Series. Not all sponsors signed nationwide deals, however.
Brooks Sports renewed as a series-wide shoe sponsor, and Mars signed a series-wide deal to promote its Marathon Bar after a three-race test run in 2011. Competitor also renewed restaurant P.F. Chang's as title sponsor of its Phoenix marathon; Sony renewed as a four-race partner; Garmin renewed for three events; and XSport Fitness clubs renewed as the title sponsor of the Chicago half marathon and a sponsor of the Washington, D.C., half marathon.
Ryan Moore, vice president of premium light beer for Anheuser-Busch, said the nationwide deal provided "value and opportunity. They've done a good job of packaging the network. We've created a pretty good footprint of individual city runs and bike races, and [the Rock 'n' Roll series] feels like more of a league."
Anheuser-Busch previously has partnered with individual events such as the Amgen Tour of California, Marine Corps Marathon and Chicago's Shamrock Shuffle.
According to Georgina Roy, McDonald's director of customer engagement, the restaurant will promote its McCafé smoothies and apple slice snacks at the events.
Dickey said Competitor is eyeing the financial services and telecommunications categories, as well as the automotive category, which saw Dodge depart after sponsoring five races in 2011.
"We felt a little pain losing Dodge, but we have a number of autos at the table," he said.
Fred Dreier is a writer based in New York.


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Nice to meet you on Audiko.net! The best opportunity to download a free Weezer ringtones for your iPhone or mobile. Scope out your favorite episodes from your favorite hit - Memories, Buddy Holly, Perfect Situation, or any other track. Then download the prepared Weezer ringtones to your phone, and enjoy Rock music by Weezer every time your phone rings. If you prefer Rock or maybe weezer and Indie music, then you will probably like Sublime, Third Eye Blind, or Ozma as well. For all who want a free Weezer ringtone, we also recommend listening to Punk, Pop, and Indie Rock. You are welcome to obtain your ringtone both in the MP3 and m4a formats, supported by both mobile phones and iPhones. Just select a track, and choose free Weezer ringtones download option.
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2 Nov 2010
13 Sep 2010
28 Oct 2009
16 Dec 2008
3 Jun 2008
9 May 2005
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- Ellie Goulding - Love Me Like You Do
- Ciara - I Bet
- Trey Songz - Slow Motion
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- Fall Out Boy - Centuries
- John Legend - All of Me
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- Ellie Goulding - Love Me Like You Do (From Fifty Shades Of Grey)
- Taylor Swift - Blank Space
- Omarion - Post To Be (feat. Chris Brown & Jhene Aiko)


text:
Manufacturing Area
Category: D/D-Sub Connectors
D-sub 9pin male connector/D-sub 9 pin male connector Brand:ADAM Series:D-sub connector 1.Specification INSULATION RESISTANCE(MIN.) 1000M OHMS CURRENT RATING(MAX.) 3amp AC 5amp DC WITHSTANDING ...Keyword : d-sub connector | 9 Pin d-sub connector | 9p male connector | d sub 9p connector | D-sub 9pin male connector
Category: Terminal block connectors
Material: housing: Nylon UL94V-0 Wafer : Nylon UL94V-0 Terminal: Phos.bronze Tin/plated
Category: IC-Card/Memory-Card Connectors
1. smart card connector 2.ISO ROHS EMV NDS 3.used :STB,Meter,IC phone . 4.stable structure and good contact performanceKeyword : Smart card connector for telephone 8pin | blade switch card edge connector | card reader housing | IC contanct card connector
1.IC card housing 2.ROHS EMV approved 3.used in POS Meters card reader 4.Stable structureKeyword : 8pin Smart Card Connector for telephone | Smart IC card reader connector
Category: PCB Connectors
1) Rated voltage: 250V AC max. 2) Rated current: 1A 3) Contact resistance: 30m? max. 4) Insulation resistance: 1,000m? min. 5) Withstanding voltage: 2,500V AC 6) Operation temperature: -40oC ~ +1 ...Keyword : Game Box Connector | board connector
Category: Cellular Phone Accessories
Various of connecting adapters, suitable lots of mobile and digital products in the market. Touch control switch, can test the available power to control well the power supply.
Category: Plugs Sockets Connectors
lemo K Series connector with the following main features: 1. Smart push-pull self-latching system; 2. Multicore types with 2 to 26 pins; 3. Solder or PCB contacts (straight and elbow); 4. Hi ...Keyword : waterproof connector | male plug connector | waterproof plug connector
lemo K Series connector with the following main features: 1. Smart push-pull self-latching system; 2. Multicore types with 2 to 26 pins; 3. Solder or PCB contacts (straight and elbow); 4. High ...Keyword : connector EGG | waterproof connector | waterproof connector K series
Category: HDMI cable assemblies
1. High speed HDMI Cable with Ethernet. 2. Data transfer rate up to 10,2 Gb/s. 3. Supports DolbyR TrueHD and DTS-HD Master Audio?. 4. HDCP compliant. 5. HDMI Ethernet Channel – Adds high-speed netwo ...
Category: USB Cables and Connectors
USB-SAF30-006SDR USB A Female 3.0 Side Dip 90° connector Specification: Contact Current Rating: 1.8 Amperes For Pin1&Pin4. 0.25 Amperes Other Contacts. Electric Withstanding Voltage: Ac 100v ...Keyword : USB A connector | USB 3.0 connector | Female connector | Side Dip 90° connector
Category: FPC / FFC connectors
FPC-SM005-242 FPC connector 0.5mm ZIF Top Entry SMT Type 24 Pin Reverse Position Specification: 1.MATERIAL housing:HEAT RESISTANCE PLASTIC UL94V-0 COVER:HEAT RESISTANCE PLASTIC UL94V-0 LATC ...Keyword : 0.5mm Pitch Connector
FPC-SMRZ03-XX10EW 0.3mm Pitch ZIF FPC connector SMT Right Angle 1.0H Bottom contact Easy-on Type Specification: 1.MATERIAL housing:NYLON46 OR HIN OR LCP UL94V-0 ACTUATOR:PPS OR LCP UL94V-0 ...Keyword : 0.3mm Pitch Connector
Category: Crimp connectors
Main Technical Parameters Insulation Resistance ? 1,000MΩ Mechanical Life 1,000 times housing Material PET G30 UL94V-0 Black Contact Spec. Power Contact #12 Quantity 3 Rated Current 35A Rated ...Keyword : UPS CONNECTOR
crimp terminal/housing/wafer connectors difference pitches arrange from 1.00mm,1.25mm,1.50mm,2.00mm,2.50mm,2.54mm,3.96mm,4.20mm,5.08mm. with difference position,ROHS complianceKeyword : wire to board connector | board to board connector | housing
Category: Power Connectors
Main Technical Specifications Insulation Resistance ? 1,000MΩ Mechanical Life 1,000 times housing Material PET G30 UL94V-0 Black Contact Spec. Power Contact #8 Quantity 8 Rated Current 75A Rate ...Keyword : CONNECTOR | PCB CONNECTOR | CRIMP CONNECTOR
Category: Flat-Cable Connectors
Pitch:1.0mm Lines:6~40 Usadable printed board thickness:0.8~1.6mm Environmental temperature:-25~+85 Rated voltage:50V(50Hz) AC,DC Rated current:0.5A AC,DC Contact resistance:?20mΩ ...Keyword : HAP flat cable connector | housing
terminal material: phosphor Bronze housing material: Nylon 46, UL94V-0 Package way: pipe package/box package dual contact or single contact suit for proper cable&PCB layout


text:
The toughest, most functional sport bike protection on the planet.
R&G Racing offers a wide range of products to fit most modern sportbikes, including frame sliders, front axle sliders, bar end sliders, exhaust and tank protectors, engine case protectors, and aluminum radiator guards. R&G Racing sets the bar high when it comes to manufacturing innovative crash protection. Modern CNC machining, aircraft-grade metals and cooperative R&D testing with the California Superbike School and motorcycle insurance companies help R&G produce the best race-proven protection & sporting style valued by the most discriminating riders. R&G Racing also offers many other accessories, including 11-position adjustable rearsets, toe chain guards and fender eliminator kits for many sportbike models.
R&G Heated Grips For 7/8-inch Diameter Handlebars$59.99
R&G Rear Axle Sliders / Protectors For BMW S1000RR '11-'15, S1000R '14-'15, Suzuki GSX-R600 '06-'14, GSX-R750 '06-'14 & GSX-R1000 '05-'14$70.99
R&G Waterproof Motorcycle Cover for Supersport and Naked Bikes - Black$79.99
R&G radiator cooler guard for Suzuki GSX-R600 '06-'14 & GSX-R750 '04-'14$119.99
R&G Exhaust Protector (Can Cover) Hexagonal shape for Honda CBR125R '11-'13, CBR250R '11-'14, CB600 '11-'13, CBR600F '11-'13, CBR1000RR '08-'15, Suzuki GSX-R600 '11-'14, GSX-R750 '11-'14, & Aprilia V4 Touno '11$79.99
R&G Front Axle Sliders / Protectors for Suzuki GSX-R600 & GSX-R750 '11-'14$59.99
R&G Racing Engine Case Cover For Suzuki GSX-R600 '08-'14 & GSX-R750 '08-'14 RHS (crank)$137.50
R&G Left Side Engine Case Slider for Suzuki GSX-R600/750 '11-'14$70.99
R&G bar end sliders for Suzuki SV1000 '03-'09, SV650 '99-'09, GSX600F '98-'07, GSX750F '98-'07, GSX-R600 '96-'14 & GSX-R750 '96-'14$46.99
R&G Left Side Engine Case Cover For Suzuki GSX-R600 '06-'14 & GSX-R750 '06-'14$112.50
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R&G Road & Race Shift Pattern Adjustable Rearsets for Suzuki GSX-R600 '11-'14 & GSX-R750 '11-'14$524.99


text:
I want to implement an iOS application which views PDF files. I have used vfr/Reader in some other applications before. But now i need to display multimedia supported PDF files on iOS which include videos, animations etc. My customer create these PDFs by using InDesign.
I made a research and can not found a proper iOS based framework to achieve this. There are really limited number of solutions like Adobe, FastPDFKit etc but they are so expensive and there is no "one time fee" option.
Do you have any open source suggestions or the ones with lower prices?
EDIT: Made a research for days and days but there is no solution. Is there any other tool to create interactive ebooks or magazines? May be HTML5 or something with editor itself???


text:
Head for the high seas and the excitement of a cruise! Choose from a long list of exotic destinations. Explore fascinating ports, relax in luxurious accommodations, and let loose with all the fun-filled activities on board your oceanliner.
Contact us today: (800) 989-3800
From $19,799.00 (USD)
Destination: Scandinavia/Russia
Ship: Seven Seas Voyager
From $10,599.00 (USD)
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Ship: Seven Seas Navigator
From $8,299.00 (USD)
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Ship: Seven Seas Navigator
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Destination: World
Ship: Crystal Serenity
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Destination: Transoceanic
Ship: Crystal Serenity


text:
Showing 1-24 of 538 items
- Sort by:
Mississippi Mud Pottery
Natural clay materials are molded and crafted right before your eyes into creative, functional stoneware pottery. Choose from a wide variety of handmade pieces to enjoy in everyday settings or as decorative objects. A popular item are the ceramic fish. Actual fish that have been caught on a hook and line are used to create a mold and clay is used to reproduce a likeness of the fish. After firing, the clay is glazed and natural or artistic colorations are applied. The finished piece is a unique one of a kind piece - a reminder of the one that did not get away! Open Wednesday-Saturday from 10 a.m. to 5 p.m. Sunday and Monday, noon to 4 p.m.
Swimming in Lake Lou Yeager is the best OWS you will have in the Midwest. There really is no comparison to this large beach with pristine flat racing water. The bike course is flat and fast with some great curves to keep you entertained the whole ride. Both the 5k and 10k runs see very honest mile paces with plenty of flats, and a couple hills throughout.
Lake Lou Yaeger
Lake Lou Yaeger, this 1400+ acre lake offers 45 miles of beautiful shoreline and several recreational opportunities. Visitors can enjoy boating, skiing, swimming, fishing, and camping. The 300 acre park has five picnic areas, two playgrounds, pavilions, grills, restrooms, and hiking trails. With miles of horse trails and a new equestrian campground with full hook-ups and shower house, Lake Lou is a great destination for horse enthusiasts. Milnot Beach has two diving platforms, showers, snack bar, and lifeguards on duty.
Live music venue and pub with full bar. Two stages and an extensive sound system accomodates a variety of live music and entertainment ranging from original songwriters, local talent and regional acts. Open F & S 4 p.m. to 12:30 p.m.
West Fork Encampment
Re-creation of Frontier and Military life of the 18th century nestled in the beautiful surroundings of Lake Lou Yaeger. There will be cannon demonstrations, period food, music and many more historical demonstrations. Located at Picnic Area #4.
Route 66 Half-Marathon
Race down memory lane during this one of a kind Route 66 Half Marathon hosted by the City of Litchfield and RaceMaker Productions. If a half marathon is too much for you, do not worry, we have a race for everyone. Try running the 5K or Mile Dash.
Big Dawg Dare
I double dawg dare you to try this Extreme 5K run at Litchfield's Big Dawg Dare. You will run over obstacles that will challenge the biggest of the Dawgs
Litchfield Party in the Park
This Litchfield Chamber of Commerce event is held at Library Park, and features annual summer carnival, complete with food, vendors and live entertainment.
Gateway Motorsports Park
Racing enthusiasts of all kinds will find special events around every hair pin from the drag strip, oval, road racing track, National sanctioned carting track as well as concerts and corporate functions. Former race car driver Curtis Francois brought back the track and the NHRA Midwest Nationals. Don't miss many of the other events that are held through the year.
Nostalgia Rendezvous
Get your adrenaline pumping watching Nostalgia Drag Racing League, Victory Super Stocks, Rat Rod Show, Gassers and Funny Cars in a fun fueled weekend!
Come in for one of the best dining experiences you will have, in a great environment, surrounded by happy people, awesome drinks and fun food. We're incredibly grateful for having had such amazing friends, family, teachers and mentors along the way. We hope everyone will share in our imagination and desire for creative cooking. Let's eat!
Mastermind Vodka
They use only select Midwestern grain that is harvested by local farmers who can maintain unparalleled control over their crop. Next they ensure perfection by working with small hand-crafted batches that can be carefully produced. This is not the easiest way to create vodka, but it's the only way to craft perfect vodka.
CITY:Pontoon Beach
Caseyville Cafe
Caseyville Cafe offers a variety of delicous American classics for the whole family.
Shiloh Valley Grill
Inside an 1800s farmhouse, the Shiloh Valley Grill has delicious American-style dishes.
Picture This & More
Preserve your family memories with the shadow box and memory box designs offered by Picture This & More, a full service custom framing store. Services include photo restoration, photo, negative and slide scanning and decorative framing to museum quality framing. This shop is located in the Piasa Shopping Center in North Alton. Open M - F 10:00 a.m. - 5 p.m., S 10 a.m. - 2 p.m.
Grace Manor Restaurant at Klingel House
Grace Manor Restaurant offers American dishes that celebrate the flavors of the season, in a warm and friendly environment. Happy Hour Tues. - Sat. 4-6.
Dew Drop Inn
At the Dew Drop Inn come in and enjoy good food and drinks.
CITY:St. Jacob
Ginger Buffet
Ginger Buffet has five types of sushi, beef & broccoli, General Tsao's chicken, and many other buffet items, a large dessert bar, a large salad bar, and much more.
CITY:Fairview Heights
Funderburk's Gas Grill & Deli
Funderburk's offers delicious deli favorites.
Come to Teller's for a unique dining experience that cannot be found anywhere else in the Metro East. They are a locally owned and operated restaurant and bar located in the historic state bank building in Collinsville. At Teller's, they try to create an elegant experience at a family price. Join Teller's for dinner and drinks tonight!
Cinco de Mayo Restaurant
Cinco de Mayo's menu is full of Mexican dishes in a warm, relaxed atmosphere.
Fortel's Pizza Den
Fortel's Pizza Den was honored by USA Today, the Riverfront Times, and many more as an outstanding "Mom and Pop" Pizzeria. Fortel's uses only the freshest ingredients, their dough is made in the store everyday, and they use 100% real mozzarella cheese.
CITY:Fairview Heights
The Sandwich Shop
The Sandwich Shop offers a large selection of fresh sandwiches such as the French dip, turkey bacon, and much more, in a cozy, small town atmosphere.
Jack's on the Green
Jack's on the Green has a large menu including fried mushrooms, buffalo chicken wings, toasted cannelloni, salmon, sandwiches, a full service bar, and much more. Part of the Stone Wolf Golf Club.
CITY:Fairview Heights


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High School Chemistry Teachers are invited to BCCE 2014
The Grand Valley State University organizers of BCCE 2014 are working to make the August 3-7, 2014 conference a valuable experience for the high school chemistry teacher.
The Grand Valley State University organizers of BCCE 2014 are working to make the August 3-7, 2014 conference a valuable experience for the high school chemistry teacher.
It is not too early to think about National Chemistry Week which is coming up October 20 - 26. This year's theme is "Energy: Now and Forever". Did you know there is a poetry contest and information about participating in community outreach activities on the ACS web site? Visit www.acs.org/ncw for more information.
Photoelectron Spectroscopy or PES is a topic included in the redesigned AP Chemistry curriculum. I have heard quite a bit of discussion surrounding this addition. It has caused panic in some teachers because they never learned it themselves, have never taught it before and/or they have no materials to teach the topic. I have been spending some time searching for a lesson plan for my own class
Greg Rushton and I attended and presented at CHEMED in Waterloo July 28th through August 1st. We enjoyed the ice cream and frozen snacks at the JCE sponsored Ice Cream Social Monday evening. We presented JCE resources for AP Chemistry on Tuesday and JCE resources for General Chemistry on Wednesday. The resources and links from those meetings are linked here.
I attended and presented at the National AP Conference in Las Vegas on July 18th and 19th! Adding Inquiry to the course is one of the major changes to how we will teach AP Chemistry. I shared some resources and gave tips during my presentation. I am sharing those resource in this post. I am also sharing items that I found especially helpful from presentations that I attended and conversations I had with other teachers.
I spent my whole prep period today playing with a site I hadn't seen before: PHYSICS 2000 @ http://www.colorado.edu/physics/2000/index.pl?Page=cover.html. I need to spend some more time there.
Celebrate Earth Day, which is on Monday, April 22, 2013. Earth Day was first officially recognized on April 22, 1970. This year the theme is "Our Earth: Handle with Care." The topics this year include water, air, plants/soil, and recycling.
If you haven't seen them yet, check out the final release of the Next Generation Science Standards. There is helpful information at the site. My home state of Michigan is currently asking for public input in order to plan support for implementing NGSS.


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FULL RESOLUTION - 1280x720
News » Published months ago
Is this Isla Fisher the Actor?
Share your thoughts on this image?
18th January 2015 @ 03:30am
Isla Fisher disclosed in an interview that she will always choose family over her career which explains her choosing supporting roles in recent years.
17th September 2014 @ 02:50am
Isla Fisher is known for being a beautiful comedic actress and she stays true to her roots in impressive performance in "Life of Crime".
FLASHBACK Isla Fisher hints at Wedding Crashers 2
8th August 2011 @ 04:18pm
It has been suggested that there could well be a follow up to the hit 2005 comedy Wedding Crashers after one of the movies stars, Isla Fisher was overhe ...


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Interactive Seating Charts
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a seating chart for Palace Theatre Southend.
Palace Theatre Southend403 London Road
Westcliff-on-Sea, UK
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Excelsior transition exam - page 4
Hello folks. I recently passed the health safety exam. Didnt do as well as I wanted for my first core nursing class. I studied for 8 days and managed to get a "C" using the TCN module and the... Read More
0Jan 19, '13 by tom5859Medic625-
I used TCN for all my Gen ed. Are you using the book and online mods or just the study guides??
Im think im going to use TCN or study101. Any other suggestions from anyone? 1 month a course seems doable. Im a ff/medic, so its nice to get other medics input on what works for you.