text:
Plane Crash
Georgia Girl Struck By Plane On Florida Beach Dies
A 9-year-old girl who was struck by a plane that crash-landed on a beach while she vacationed with her family has died from her injuries, law enforcement officials in Floridasaid Tuesday.
Father Killed, Daughter Injured As Plane Crash Lands On Beach
A man was killed and his daughter was seriously injured when a small plane crash landed near Venice Beach on Florida's Gulf Coast Sunday.
Police ID Pilot Who Crashed Off Elliott Key
Miami-Dade police have identified the pilot who died when a Cessna 172 he was in crashed off Elliott Key Sunday afternoon. Ricardo Laporta Barboza, 51, of Coral Gables was at the controls when the plane went down about 200 yards east of the island.
One Dead After Plane Crashes Near Elliott Key
A small Cessna 172 crashed south of Elliott Key Sunday killing one person, officials said.
Pilot In Southwest Florida Small Plane Crash Identified
Authorities have identified the pilot of a small plane that crashed into the waters off a southwest Florida island.
Officials: 2 Killed in Central Florida Plane Crash
Two people on board a small plane were killed when the plane crashed into a Central Florida neighborhood.
Three Dead After Small Plane Crash In Panhandle
Three people died after a small plane crashed in Florida's panhandle on Sunday.
Small Plane Crashes Into Tampa Bay
It was a close call for a pilot who crashed his small plane into the waters of Tampa Bay on Sunday but safely escaped.
Banner Plane Crashes In Northeast Miami-Dade Lake
A small bright yellow banner plane crashed into a northeast Miami-Dade County lake Friday afternoon.
One Person Killed In Wellington Plane Crash
One person was killed when a single engine plane crashed into a Wellington lake. The crash happened just before 1 p.m. near Greenbriar Boulevard in Aero Club, a private aeronautical community.


text:
Paradise Point
Sioux Narrows, Ontario
Phone: (807) 226-5269
Sites: 60
Recent Rate: $30 7/2007
Latitude: 49.3850152479117
Longitude: -94.0694038253784
These reviews are the opinion of an RVParkReviews' member and not the views of RVParkReviews.com
Date of Stay: July, 2007 - $30.00
The location of this park is on Snake Bay of the beautiful Lake of the Woods. The water is crystal clear and there is a beautiful beach. The managers were very friendly. I had to prune the trees to get my coach in and out of the site. The restroom facility is clean, but old, and the building had a pay shower. Wharfage costs 11.50 per day. There are a lot of seasonal campers here, some who have been coming here for years. Good fishing here, from the dock or out in the lake. We camped at Paradise Point in a Motorhome.Undo
1 Ratings
Lake Powell, Utah
13 Ratings
Circleville, Utah
Pre-Register below to access free and enhanced features coming in the near future.
Access to marketing tools, ability respond to reviews and monitor performance as well as expanded listings.
Essential Marketing resources, page insights, daily reports, setup and manage notifications of newly posted reviews.
Expand your listing, Add photos and videos, update business details and more.
More Information about our Campground Owner Management and its enhancements are coming very soon. Features subject to change.

subset: commoncrawl


text:
Scientific Advances In Hiv Vaccine
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
Cure (HIV VACCINES)Dear Dr. Bob:Thanks for your sterling job you offer to the community. My question is: the HIV virus is the most studied virus and its behavior as well as functionality is well-known. Why then no vaccine has yet been developed though billions of...
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation...researches' jobs and funding grants. That is conspiracy-theory nonsense. The reason we have not been able to develop an effective HIV vaccine is related to the complexity of the virus and the fact HIV destroys the body's immune system as the... Read more »
Samir Chachoua (HIV VACCINE)dr. bob please watch this- do you know this guy???? (Submitted Jul 16,... Read more »
hiv vaccinedear sir,my husband is hiv positive. im worried about him.he thinks hiv is most dangerous and asks... Read more »
HIV/AIDS Researchers, Government Officials Track Progress, Forecast Challenges Ahead for HIV Vaccine Development...HealthBeat reports on the tempered optimism expressed by scientists participating in the international meeting over the viability of HIV vaccine in the near future. "There is some really good news but there's a long way to go," Anthony Fauci,... Read more »
Nine Years and Counting: Will We Have an HIV Vaccine by 2007?...Summary Introduction Agenda for Action A Year of Good Words and Gradual Advances (chart) Overview of HIV Vaccine Research The National Institutes of Health (NIH) Battling the Bureaucracy NIH HIV Vaccine... Read more »
Team of Scientists Issues HIV Vaccine Strategy... The Council of the Global HIV Vaccine Enterprise on Tuesday released a new strategy for HIV vaccine research, which marked "the culmination of an 18-month effort that Read more »
National HIV Vaccine Awareness Day...of the National Institutes of Health, have been working for more than two decades with our colleagues worldwide to develop an HIV vaccine, and this research continues to rank among our top priorities. National HIV Vaccine Awareness Day marks an... Read more »
Connect With Others
HIV vaccine in the making
Posted by Anonymous, 1 ReplyRead this article below and someone explain a couple of things to me..i am a health care professional, and part of my job is HIV/AIDS education. during my trainin on HIV i was told and (i teach this as well to my students) that people can't get HIV... Read more »
HIV Vaccine Scam
Posted by Anonymous, 5 Replies...RedFlagsDaily.com) I told you so. I told you so in the scientific literature. I told you so on the internet. I told you that an HIV vaccine would never work. This week, the long-awaited results from an independent trial of the world?s best... Read more »
Workplace issues and HIV/AIDS
Posted by ScotCharleshttp://www.thebody.com/workplace.html Check out this link for workplace issues with HIV/AIDS. It is very thorough. Read more »
HIV/AIDS Blogging/Blogs
Posted by DaveyBoy, 2 RepliesBlog is online (web based) journal or small blurbs people can read or comment. My HIV/AIDS blog is on http://hiv-aids.blog-city.com Other POZ blogz on http://www.HIVforum.com/blogs/ Read more »
Resource Centers
Guides for People With HIV


text:
Medium Size Nickel Plated Hand Bell with Black Lacquered Hardwood Handle ! Nickel Plated Brass Bells were popular Circa 1880 to 1920.
Measures 6 1/2 inches High.
Weighs about 10 Ounces.
Condition : Brass bell has originally been nickel plated with some normal faint losses on one side. (nickel plating is typically only 1/10,000 of an inch thick)
Item ID: 3747
If you were the pending buyer of this item, go to My Account to view, track and check payment for this item.
Original Antique Americana , U.S. Militaria , Original Photos, Period Lighting , & Fine Art Prints.


text:
So I'm building a 4 tap keezer. Have the perlicks, freezer, building materials, etc. I'm turning my attention to CO2. I have 5lb CO2 tank and a double gauge regulator (cant remember the brand. has a blue body and came from a Danby kegerator I believe). I know I definitely don't want just a 4-way manifold. I think that the ability to have three different pressures would be best, but I could be convinced to go for 2 or 4. So, taking into account what I already have, how should I do it? Buy two more primary regulators and link together? Buy three secondary regulators? 1000 pts to whoever plans this out for me in such a way that is reasonably cost effective, but not of cheap quality.
Up Next: Coffee Stouts, Brett Beers, More Sours, Quad, Brown
Primary: Sour
Secondary: Sour
On Tap:
Bottled: The Queenella Dugbe RIS, Avlan RIS,
What about this guy?http://www.chicompany.net/index.php?...oducts_id=2641
I went with a 4 way in the fridge and then a splitter off the tank outside the fridge. This way I can purge/carb outside. I suggest the Micromatic. I went a slightly cheaper route but wished I didn't.http://www.beveragefactory.com/draft...egulator.shtml
First they came for my Four Loko and I said nothing, then they came for my Double Imperial Espresso Stout.
I'm also a newb, planning my first keezer. Help me out here, why would I need different serving pressures for each keg? Aren't most kegs going to be fine if served at 12-15psi? Does the small amount of control offered by multiple regs justify the additional $200+?
here is a good price on one4 way secondary..
once we get an upright freezer for foodstuffs i plan on "retiring" my chest freezer just for this :-)
~ A fine beer may be judged with only one sip, but it's better to be thoroughly sure.DOWN THE HATCH BREWINGStainless Hop Spider | Wooden Brew Rig | Dual Hinge Keezer BuildPrimary: Apfelwein
Keg 1: Nugget Nectar Clone | Keg 2: Breakfast Stout | Keg 3: Oaked Bourbon Vanilla Porter
Bottles: lots full and even more empty
I have a single reg with a 4 way manifold. It works great for me as I'm just starting out and on a budget. I plan to get a secondary reg body from kegconnection for under $40 so that I can serve Belgians or stouts at the proper co2 volume. A four way is most likely overkill unless you have a mild, IPA, Belgian and soda going at the same time. Might as well get a 2 body reg with 2 way splitters for each. Serve 4 brews at 2 different pressures.


text:
Star Tracks
Theron hangs courtside at the Lakers game in L.A. Plus: Justin & Jessica, Jennifer Garner, Heidi Klum and more
Credit: John Sciulli/Getty
Published: Monday Apr 15, 2013 | 05:00 PM EDT
More from PEOPLE
Latest News!
- Wait Until You Read What Martha Stewart Said to Justin Bieber at His Comedy Central Roast
- The Best Photos from the Week of Mar. 23- Mar. 29, 2015
- Mother Allegedly Smothers Her Child in NYC Restaurant Bathroom
- Iggy Azalea Talks Britney Spears Duet: Grabbing Lunch, Becoming Friends
- Cate Blanchett on Watching Her Three Sons Bond with Baby Edith: It's Extraordinary


text:
StartUpHire is the place to find Data Reviewer jobs. Review the list of Data Reviewer career opportunities to the left. These Data Reviewer jobs represent some of the most rewarding careers available.
You can refine your job search for Data Reviewer career opportunities by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options.
Don't see the employment opportunity you're looking for? Check back soon for more Data Reviewer jobs, or sign up for an email alert (link below) to receive periodic updates on new Data Reviewer jobs.
Description JOB SUMMARY: The Senior Medical Director plays a vital role in both the development and implementation of Health Integrated clinical program designs, policies/procedures and strategies. The Senior Medical Director is responsible for clinical direction and support to2/17/2015 Tampa, FL Save This Job
Job Description POSITION SUMMARY: Support the transition of a Research Use Only scientific tools company to one that provides in-vitro diagnostics and regulated products to select market segments. Strengthen our compliance of Production and Process Controls, Risk Management2/2/2015 Billerica, MA Save This Job
Zosano Pharma, Inc. is a specialty pharmaceutical company creating better products utilizing innovative drug delivery technology. We have developed a user-friendly, simple, and needle-free transdermal delivery system consisting of a patch and applicator ? that is proven capable2/10/2015 Fremont, CA Save This Job
ID 2014-1510 Job Locations US-NY-New York City Category Learning and Development Travel .. Level .. Options: Apply for this job online Refer a friend to this job More information about this job: Overview: We are seeking a Technical Writer to create customer and internal2/16/2015 New York, NY Save This Job
Reporting into the Vice President of Medical Affairs, the Senior/Executive Director will be part of the Medical Affairs organization at Aegerion headquarters in Cambridge and will contribute to the medical/clinical output from that team. A key part of this role will be to serve2/21/2015 Cambridge, MA Save This Job


text:
MedicareSee more about Medicare
Filter Results
- results
- state & global data
- slides
- view as grid
- view as list
Testimony: Rethinking Medicare's Benefit Design: Opportunities and Challenges
Foundation Senior Vice President Tricia Neuman testified June 26, 2013 before the House Energy and Commerce Committee Subcommittee on Health about Medicare's benefit design, and the implications of possible changes for beneficiaries, other stakeholders, and program spending.Issue Brief Read More
Income and Assets of Medicare Beneficiaries, 2013 – 2030
This data spotlight, co-authored by researchers at the Kaiser Family Foundation and the Urban Institute, describes the income, savings, and home equity of current Medicare beneficiaries, considers variations by race, ethnicity and other demographic characteristics, and examines the extent to which income and assets are projected to be higher among the next generation of beneficiaries.Issue Brief Read More
Healthier and Wealthier, or Sicker and Poorer? Prospects for Medicare Beneficiaries Now and in the Future
This January 2014 briefing, co-sponsored by the Kaiser Family Foundation and the Alliance for Health Reform, examines what is known about the health and economic security of Medicare beneficiaries today, as well as how current and future beneficiaries may be affected by the leading proposals that aim to achieve Medicare savings.Event Read More
Webinar for Journalists: How the Affordable Care Act Affects Baby Boomers and Medicare Beneficiaries
As part of the "Covering Health Reform" series, this webinar focused on the major changes facing older people. The Foundation's Associate Director of the Program on Medicare Policy, Juliette Cubanski and Senior Fellow Karen Pollitz discussed how the Affordable Care Act impacts Medicare benefits and beneficiaries, as well as the ACA's role for baby boomers who are not yet 65 and eligible for Medicare.Event Read More
Medicare Advantage 2014 Spotlight: Plan Availability and Premiums
This data spotlight report examines trends in the Medicare Advantage marketplace, including the choices available to Medicare beneficiaries in 2014, premium levels and other plan features. Medicare beneficiaries, on average, will have 18 private Medicare Advantage plans available to them in 2014, reflecting both new plans entering the market and old plans exiting it. If Medicare Advantage enrollees remain in their current plans, average monthly premiums will rise by almost $5 per month, or 14 percent, to $39 per month. The analysis also examines some benefits provided by Medicare Advantage plans including drug coverage and caps on out-of-pocket spending, and finds that average out-of-pocket limits across all plans will climb 11 percent to $4,797 in 2014. Additionally, this analysis examines changes in the types of plans available (HMOs, PPOs, etc.), including special needs plans in 2014.Issue Brief Read More
Development of the Financial Alignment Demonstrations for Dual Eligible Beneficiaries: Perspectives from National and State Disability Stakeholders
This issue brief provides an early snapshot into disability community perspectives on state design and implementation efforts related to the new financial alignment demonstrations for beneficiaries dually eligible for Medicare and Medicaid, with an emphasis on non-elderly beneficiaries and those who use long-term services and supports.Issue Brief Read More
Streamlining Cost Sharing in Medicare: The Impact on Beneficiaries
This July 22, 2013 briefing, Streamlining Cost Sharing in Medicare: The Impact on Beneficiaries, explored the impact on beneficiaries of recent proposals to combine the two main parts of Medicare.Event Read More
Health Care on a Budget: An Analysis of Spending by Medicare Households
This report examines Medicare beneficiaries' out-of-pocket health care costs, which comprise a significant share of their household expenses.Report Read More
Medicare Advantage 2013 Spotlight: Enrollment Market Update
This Data Spotlight provides an overview of Medicare Advantage enrollment patterns in March 2013, and examines variations by plan type, state, and firm. It also analyzes trends in premiums paid by beneficiaries enrolled in Medicare Advantage plans, including variations by plan type, and describes the out-of-pocket limits and prescription drug coverage in the Part D "donut hole" provided by the plans in 2013.Issue Brief Read More


text:
Steven Waldman
On The Media
Requiring Local TV Stations to Disclose Political Ad Buys Online
Friday, January 06, 2012
Local television stations are required to maintain a public file of political ad sales, and allow any member of the public to inspect it–as long as they physically come in to the station. To make the information more accessible, the Federal Communications Commission is proposing regulations that would require local broadcasters to put the public file online. Bob speaks to former FCC adviser Steven Waldman, who says that putting the information online is the least that broadcasters can do to fulfill their public interest obligations.
Supported by
- The Cancer Show: Part I
- House of Cards Recap: What Would Jesus Do?
- Confession and Suppression
- The War on Prevention
- Every Edit You've Ever Made to a Facebook Post Is Visible
- Do URL Believe in Magic?
- Perception vs. Reality
- What Makes a Great Disease Story?
- Speaking in Tongues
- The Breaking News Consumer's Handbook


text:
lilelfo, justin thomas kay, and 14 other people added this photo to their favorites.
love the birds!
This one is about the "1978 International student festival" in Cuba.
Nice. Very sharp. Rainbow, sky and cloud ...
Hi, I'm an admin for a group called Postage Stamps: Wee Works of Art, and we'd love to have your photo added to the group.


text:
Strathearn Home Page
There are still lots of things changing on a daily basis and you can keep track of these on Facebook - we are just so busy finishing the distillery that the website is not up to date !
But it is on its way!
Contact us on email@example.com


text:
Hello, my name is Lindsay Mandeville. I am a sophmore pitcher for Adrian College located in Adrian, Michigan. I heard about this website and the possiblity of playing overseas from our coach who is going to coach this summer. I have always had the interest to play overseas but never really knew how to get involved. I am in my second year of pitching for the college.I started as a freshman and my pitches include fast, change, curve, screw and occasionally a rise and drop ball.
I would love the opportunity to play overseas if anyone is still looking for a pitcher!
I can be reached through email at:
email@example.com or firstname.lastname@example.com


text:
Natural Resources
2015 Seedling Tree Program
Once again CSU Extension will be offering Seedling Trees in cooperation with the CSFS. There is no longer a minimum acreage requirement. San Miguel Basin Extension Office is currently taking orders for the seedling trees; deadline day is around April 11th, the trees will be ready for pick-up in mid-May.
To qualify for the program:
Seedling Tree Application to order trees
Bare root trees, small potted and regular potted trees are offered in lots of 25 or 30 at a nominal cost.
February 18-19, 2015
Montrose Pavilion Center
1800 Pavilion Dr. Montrose, CO
Download the pdf Registration form
Website: http://wci.colostate.edu/
If you want to be a Native Plant Master or if you want to be on our email list, Email Mary or call our CSUE Office in Norwood at 970-327-4393 for more information.
- CSU News
- CSU Energizer Newsletter
- Sept Energy News
- August Energy News
Other Resources
- Solar Energy Info
- Consumer Federal Rebates
- Tree Inventory, click here
- CSU Forest Service Buyer's Guide for Seedling Trees
- Trees Species Suitability Guide
- CSU Trees Planting Guide
- CSU Forest Service Planning & Planting & Care for Seedlings
- 2015 SMB Seedling Tree Application
- Seedling Survival Supply Catalog
- **Fruits of Your Labor Cookbook
- Back-Yard Pest Management
Pest management can be one of the
greatest challenges to the home gardener.
Yard pests include weeds, insects, diseases, and some species of wildlife.


text:
Learn how to finance your film and then come back to watch Leos Carax's surrealist masterpiece.
Upcoming Events
Event Finder
Restaurant Finder
The Weekender
Subscribe to The Weekender, Louisville's weekly guide for where to go and what to do!
Most Read Stories
- Ear X-tacy Graffiti Appears on Bardstown Road Panera
- GonzoFest Louisville Raises Funds for Hunter S. Thompson Statue
- 2013 Louisville Area Child Support Arrears List (Deadbeat Parents)
- Louisville Long-Term Bucket List
- Little Free Libraries Around Louisville
- Where to Go and What to Do in Louisville This Weekend (March 19 - 22)
- Where to Go and What to Do in Louisville This Weekend (March 26 – 29)
- Welcome NCAA Basketball Fans: Your Louisville Guide
- 15,000 people are headed to Louisville for the VEX Robotics Championship
- Review: Storm Large Wows The Mercury Ballroom


text:
Greatness is lifting up from underneath. Jesus says to his disciples that the gentile rulers "press down on them..." The donkey presses up from underneath. Greatness, like the donkey's, means lifting up.
Worship is the overflow of God's own life inside us. Even deeper, our worship is the overflow of God's own life from inside us. It's not just "me and God." Together, we pray, learn, serve and celebrate.
Every Sunday we have five services in two venues, the Sanctuary and the Summit.
Dress – People dress from casual to Sunday best in all services.
Parents – In proximity to both worship venues there are comfortable café worship spaces for nursing moms as well as young families.
After worship, our praise on the inside becomes action on the outside. We go out to care for the poor, love our neighbors, befriend the stranger and share Christ out of love for God.


text:
Explore destinations in Europe, Middle East and Far East Asia for luxury travel
Jumeirah Restaurants and Bars are renowned for their 5-Star quality food and creative cuisine, but most of all for choice.
Indulge in the ultimate journey of tranquility and experience the world's most luxurious spas in stunning locations.
Take advantage of the amazing offers available at Jumeirah Hotels and Resorts in Europe, the Middle East & Far East regions. Book online today.
Exclusive events deserve an exclusive address. Choose from exceptional destinations for venues that capture the ambience of your special event. Inspiring and innovative, our venues are fitted with the latest technology and state of the art facilities.
Sirius, Jumeirah's Recognition and Rewards Programme, has been created to offer you an exclusive membership that opens up a world of privileges. Available at every hotel, resort and residence around the world.
Currently in Dubai:
Relax in the cool evening breeze of the Arabian Gulf and savor fresh local seafood and grills at Khaymat Al Bahar restaurant by the beach.
Inspired by Bedouin tents, Khaymat Al Bahar restuarant is open for breakfast, lunch and dinner with a daytime menu of imaginative international light fare. By night, the beachfront becomes the perfect spot to enjoy sunset drinks with friends and family before a sumptuous dinner of grilled meats & seafood classics in a lively and casual setting.
Along with a premium choice of Arabic grills, rib-eye or lobster – all flame-grilled to perfection, delight at tempting appetizers and fresh salads. End the perfect feast on a sweet note with a selection of succulent desserts with the best bechside view in Dubai.
Pool side, Al Qasr, Madinat Jumeirah
International Light Fare
Daytime: Casual Evening: Smart casual
Serving from 06:30 to 11:30
Serving from 12:00 to 17:45
Serving from 13:00 to 15:30 (Fridays only)
Serving from 19:00 to 23:30
+971 4 3666730


text:
Keep Reading
- 75 Recipes That Make Us Crave All the Green Things
- How Chef Ludo Lefebvre and Jewelry Designer Irene Neuwirth Throw a Dinner Party
- The Weekend Cocktail We Could All Use Right Now
- Meet Wassail, New York City's First Cider Bar
- Rhubarb, Peas, and Ricotta: Here's How BA Staffers Are Celebrating Spring This Weekend
Grilled Flatiron Steak with Toasted Spice Vinaigrette
Let the steaks rest on top of the tomatoes. Their juices will commingle and make the dressing that much better.
Loading Comments...


text:
Reviewed By Tamara M (Rosedale, MD) Reviewed for a 2010 Honda Accord —2/5/2015 12:45 AM
Shipping was ok. Took a little longer due to weather. I do like how well they catch water and dirt. I would have bought the trunk liner if the package deal was a little cheaper. Appears plastic instead of rubber. Could fit more snug on the sides. It may conform over time. I would suggest others to buy them.


text:
|ESPN: SportsNation
Hello all. Trust everyone had a safe and fulfilling Thanksgiving break. So, where were we?
Enjoyed your articles about the Canes the other week. What's your take on the coaching change? Do you anticipate Muller having an immediate impact like Hitchcock had with the Blues?
Bill; Thanks for your kind words. And I do think Muller is the kind of guy that will have an immediate impact. My guess is you'll see some more jump from Eric Staal - not necessarily a comment on Paul Maurice but simply change is likely to energize the team captain. The question will be whether Muller can get the 'Canes to elevate their level of play for more than the short-term. There are still lots of issues with the make-up of the team and coaching won't cure all of them.
What do you think of NYRs chances at a conference final berth (or possibly more) this year? Gaborik looks reborn, Richards is as advertised, Lundqvist off to best start of his career and defense will improve tremendously when Staal returns.
Alex; I think the Rangers' play of late suggests they can play with anyone in the conference. Pittsburgh looms large with Crosby. That goes without saying. Can the Rangers keep up with them or a healthy Flyer team over a seven-game series. I would say a final four berth is definitely possible but Lundqvist will have to have better post-season performances than in recent years for that to happen.
Has Dale Hunter ever gotten serious Head Coach consideration from another NHL team prior to today?
Chris; I know George McPhee and Dale Hunter are long-time friends and my sense is that Hunter had made it clear he was happy with his junior team in London which has been a roaring success. He said today Washington was the only reason he'd have left London so while there might have been inquiries I think this is where it was going to happen for Hunter if at all.
Boudreau and Maurice are gone and their teams had more wins than the Ducks. Any chance they get rid of Carlyle and/or Murray?
Alex; I will be surprised if there isn't a significant move surrounding the Ducks in the next two to three days. Trade? Maybe. But as we know big trades are hard to come by in this NHL so that would suggest Randy Carlyle's days are likely numbered in Anaheim.
With Schneider playing well for the Canucks, how much longer will Luongo starts again?
Ice Ace; I don't know that there's any timetable for Luongo's return but it makes for an interesting dynamic when he comes back given how Schneider has moved nicely into 'starter' mode even if it is short-term. Luongo's struggles prior to being injured will continue to be a storyline for the Canucks until he can get back into a groove. Could make for some uncomfortable days in Vancouver and some uncomfortable decisions for Alain Vigneault. Still, Luongo's job will be secure when he comes back. At least until April.
Wow. The Penguins aren't #1 in the Power Rankings this week. Are you feeling okay? Or did Pierre do the rankings?
Tom; No. I did them. Easy answer is that they're not deserving of the top spot. Not yet anyway. We'll see how Pierre likes them after this week.
Are the Capitals done making major moves? How active will they be before the trade deadline?
matt; I think a lot will depend on how quickly Dale Hunter gets the ship turned around. I have no doubt they will play better but the defense continues to be an issue and if Green remains in and out of the line-up and Hamrlik's play doesn't improve I will be shocked if George McPhee doesn't move to bolster the blue line. Plus there's the obvious potential for Alexander Semin to be dealt a kind of addition by subtraction move if the team continues to struggle.
What do you think of the Leafs so far? Playoffs this year? or hitting the links early again?
zack; For me the telling time has been in the last couple of weeks where instead of continuing to slide off the map the Leafs have righted the ship. I like them to hang around for the post-season dance. Not sure how long they'll last but at this stage any kind of playoff presence would be a bonus for Leaf Nation, no?
Lots of coaches have been fired mid season already...Will Terry Murray be next? His "system" as it's called around here is obviously hurting the Kings chances of even making the playoffs with the "dump and chase" mentality. How long is his leash? The Kings have too much talent to NOT be dominating the league.
Bucky; Agreed that the Kings are too good to be where they are in the standings currently flirting with a playoff spot. My sense is that Dean Lombardi will look at a variety of remedies before he fires Terry Murray that said your point is a good one and that is whether Murray's style fits a team with this much talent. No question they should be better and the pressure to take a step forward this season isn't good for job security.
with zajac skating, and most likely returning to practice in the next 1-2 weeks, what do you think would be best for the devils, as they need to get kovy back on his side (LW)have parise play with zajac or kovy and zajac, with the other playing with henrique?devils a playoff team?
pete; This isn't Pete DeBoer is it? Agreed that Kovalchuk needs to play on the left side if that's possible. Also need to see where Zajac is at in terms of his durability. And yes, I think the Devils are a playoff team. Larsson and Henrique have provided a terrific boost and if Brodeur can stay healthy they should sneak into the post-season.
I want to believe in this. Valtteri Filppula looks like the player Wings management and fellow country man and future Hall of Famer Teemu Selanne have been telling us about for years. Is this a fluky hot streak, or is he finally putting it together? I really think he is driving the net harder and shooting more, so 60-70 points is realistic right?
Josh; Not equating Filppula to Datsyuk or Zetterberg but those are guys that took some time to grow into their skins. Certainly Filppula is never going to get a better opportunity to shine playing with talent and getting quality minutes. As for point totals if he's not 60-plus then the Wings will find it difficult to earn a top seed and venture far in the playoffs.
Kudos to the Wings for knocking off the red hot Bruins, but I watched that game and Jimmy caried them.....the Bs looked like they outplayed them all game long....thoughts? Stanley Cup for both?
Rich; Long way to go for those two to meet again in late May but that was a heck of a game. And you're right Jimmy Howard has been the Wings' MVP so far. Vezina anyone? As well as both are playing I still have trouble imagining either in the final when the dust clears. I think it's too much to ask of the Bruins two years in a row and the Wings just don't match up, in my mind, with Chicago, Vancouver or San Jose over a seven-game set.
How much longer before the Flames show up on the trade tracker? Who's likely to be involved?
EJN: Well rest assured GM Jay Feaster is working the phones and you know Brent Sutter is hoping he doesn't get a call from Feaster himself. But the problem for the Flames is that no one wants the guys he'd like to deal; Jokinen, Stajan et al and he's reluctant to trade the guys who do have value like Kiprusoff and Iginla. At some point something has to give.
Any chance of Teemu Selanne playing a few more years? At 41, averaging nearly a point a game, he should be good for another 3-4 years!
Xander; Not the way the Ducks are playing. Wondering if Selanne is having regrets at agreeing to come back at all this season. But you're right, he's terrific and is the team's best player right now. Wonder if he'd think about asking for a trade to the Jets?
How come no one talks about how good Mike Smith has been? Coyotes 7th overall in goals against. The guy has been better than good.
Matt; I spoke to Mike and to Dave Tippett not long ago about his terrific start and you're right on, he's been key to the 'Yotes hanging around the Western Conference playoff picture through the first quarter of the season. He has really picked up a lot from Sean Burke and the question is whether he can maintain that level of play throughout the season. If so, wouldn't be surprised to see his name come up in Vezina talks.
After last night's thrashing in Anaheim, any chance the leafs can get them to bite on Schenn, Grabovski and Kadri for Ryan? Is that a decent offer or would they require more? i would hope that Murray will still deal with Burke... Thanks for the chat
Matt; Bobby Ryan's name has come up in trade rumors and given the strong bond between Burke and Murray I wouldn't be surprised if there's a deal to be made there. Ryan would look good with that suddenly potent Leaf offense and at this stage Murray has to be looking to the future in terms of young prospects. Schenn's star has definitely waned in Toronto. Hmmm.
I can't figure out the Blackhawks at all. Can you help? What is their bigger need: another top-6 forward or a stay-at-home defenseman?
Matt; With you on the 'Hawks. When they're good they look as good as any team in the league. But when they go sideways, well, forget it. Still think defensive depth is something Stan Bowman will be pursuing. Can't have enough.
What is your opinion of Kris Versteeg's play this season? Wish he was still on the Hawks.
Ivan; Spoke with Versteeg during training camp and he said he'd finally corrected some core body issues that had been bothering him the last three years or so. Skating free from pain and now has the jump that makes him so dangerous. Also, he's one of the go-to guys now in Florida and I think he's thriving on that. One of the best if not the best off-season acquisition in the league right now.
Can I help turn the Blue Jackets, Ducks, or Flames around? I'm pretty familiar with the western conference...
Marc; I would be surprised. I think the disappointing results in Dallas and before that in Los Angeles means you're destined to do some more TV analysis before the door opens again for you. But you're very good on TV.
Scott, why not always have the Winter Classic on a neutral ice? I have a great suggestion for the one in 2013-- Red Wings vs Avalanche at Lambeau in Green Bay! Hockey in the frozen tundra-- doesn't get any better that that...What do you think?
Sergei; Love the idea of a game at Lambeau. But the danger is that you take the crowd buzz out of the equation when it's neutral site. The Premier Games in Europe, for instance, lack the buzz of a 'real' game. Love the fans in Boston or Chicago going crazy for their teams so I doubt if the NHL will go away from that. How about the Big House next year with the Wings hosting Chicago?
How much will Kari Lehtonen's injury hurt the Dallas Stars playoff push? Thanks Scott!
ted; Don't want to say 'I told you so' but my question even when the Stars were as hot as they were was how long Lehtonen could keep up the pace. He has a history of injury woes and has never been able to sustain the workload of a true Number 1. Lots of pressure now on Andrew Raycroft to hold the fort. My guess is that this will not go well for the Stars.
no calls on ice, will I be suspended?
Max; Guessing two games. Maybe three.
Hey there, Scott. As a Devils fan, I've already begun realizing these could be Parise's last couple of months in NJ. That being said I've begun thinking of trade scenarios and possible suitors. Who do you think is an early favorite given team needs and potential moveable prospects? I'm thinking Vancouver for Schneider and Hodgson...?
JD; Difficult decisions ahead for Lou Lamoriello and Parise. If they are where they are now, a bubble team, and Lamoriello hasn't inked Parise to a long-term deal hard to justify not shopping him. Los Angeles has tons of young talent and lots of cap room (assuming any team acquiring Parise will be looking to sign him to a long-term deal themselves). Vancouver is interesting but not sure they part with Schneider pending Luongo's health/mental state. What about Detroit although they're more likely to get in on Parise on July 1. Lots of interesting options if it comes to that.
i know ... i'm late ... with pronger down, does philly try to pull the trigger on a defensive trade for a big name (cmon weber...) ... our D is a turnover machine without the big guy back there.
brett; Well we know there's lots of history between Nashville GM David Poile and Flyers GM Paul Holmgren but it would take an awfully big package to get Weber out of Nashville at this stage. Preds need to find out where they're at with Ryan Suter before they make a move with either of their core defensemen. And yes the Flyers have been curiously porous without Pronger in the line-up. Still early though and he's only going to be gone a month or so (I know that seems like a long time but relatively speaking better now than in March, no?)
you said earlier you don't believe the wings have enough, what would it take for them to have enough, they have the cap space? another defence man, a power forward or two that can score??
Danny T; I'm not sure they're got enough depth up front for a four-round run. And not sure the blue line is deep enough for that kind of run either. Having cap space is more valuable for them on July 1 than at the trade deadline as it makes little sense to give up prime assets for players that aren't part of the long-term plan in Detroit.
your get to do the 09 draft again - if your edmonton do you still take Hall or would you prefer seguin now
charles; Pretty small sample even if Seguin has a Cup ring already and is lighting it up this season. Too early to have buyer's regret on this one I think.
Do you see any weaknesses on the current Penguins roster? At this point, I really see no areas of concern and would be surprised if any big deals were made this year (unless there is an injury).
Joe; Assuming every team was healthy it's hard to imagine a team with fewer holes than the Penguins. Fleury has been terrific in goal, the blue line has a nice blend of skill and toughness plus experience and the top nine forwards have a pretty nice blend of grit and skill. Could you use another skilled winger perhaps? Maybe but right now this is as complete a team as there is in the league. We'll see how they look come mid-April.
Should the Sharks be worried about Dan Boyle? His play has dropped off considerably, although it's been tough to realize because of Burns/Vlasic excelling. We need him at the top of his game for us to succeed in April and beyond.
Tim; If Dan Boyle sat with his feet up on a footstool with a keg of beer at his side until April it wouldn't matter. He's a heart and soul guy, a Cup winner, that will be vital to the Sharks getting over the hump next spring. I wouldn't sweat some down time in the first quarter of the season.
Which type of game would appeal to the average sports fan, and not necessarily hockey fan: Bruins vs Sabres or Bruins vs Red Wings? Why would the NHL showcase the Wings, when they're style of play doesn't appeal to the non hockey fan base?
Lane; Pretty sure the decision to showcase those two teams was based on the hockey markets they represent not the style they play. And I wouldn't mind watching either of those match-ups - like most hockey fans I suspect.
Scott, Do you see Colorado trading Stasnty? if so who or what could they get for him?
brian; Pressure is mounting in Denver to do something. Stastny's name comes up because he's a skill guy with some experience but his contract, two more years at $6.6 million, makes him a big bite. The dilemma for Greg Sherman is that you don't want to trade parts of what is an impressive core of young players just to make change. Honestly I think they'll make a coaching change before a roster-disrupting trade.
What do you think is the FL Panthers biggest need at this point in the season and can they finally get into the playoffs?
Rich; Well, need to make sure they get consistent goaltending through the next couple of months. Scott Clemmensen is back and he needs to be able to take some of the weight off Jose Theodore. Better balanced scoring up front would be helpful, too. But I do think they're a playoff team. Fans, what few of them remain after a decade of misery, deserve this.
With the Rangers looking good now, it seems that the biggest weakness is when they play fast teams (Florida, Montreal), would you assess that to be their weakness?
Jason; I think the Rangers like to play an in your face style and make life difficult for opponents in their own zone, create turnovers. So teams that can avoid that and then create offense off the rush are difficult to contain. Not sure it's just the speed factor but the speed in the transition game. Obviously whatever flaws the Rangers have they haven't been very obvious in recent weeks.
Okay folks, time to run. Headed to Washington tomorrow to check out the Hunter era's beginning. Thanks as always for dropping by. Talk next week.


text:
This item is in the shop's backroom and cannot be purchased at this time.
If you are the shop owner, Sign In above to view this item.
Item ID: NWV001
We create wearable art for you to enjoy and pass on as heirlooms.
FREE Domestic Shipping & Insurance for all purchases over $100!


text:
Illinois Public Media
All articles tagged National Security Agency
Facebook's Mark Zuckerberg Takes White House To Task Over Privacy
Snowden Says Allegations He Received Russian Help Are 'Absurd'
House Intelligence Chairman Implies Snowden Had Help From Russians
Obama Calls For End To NSA Holding On To Call Data
Newspapers: 'Whistle-Blower' Snowden Deserves Clemency
Report Details NSA's Alleged High-Tech Tricks For Snaring Data
Federal Judge Rules NSA Phone Surveillance Is Legal
NSA Collecting 5B Cellphone Locations A Day, News Report Says
Sen. Feinstein: 'Total Review' Of NSA Activities Needed
Guardian: U.S. Monitored Calls Of 35 Foreign Leaders
Are We Moving To A World With More Online Surveillance?
Reports: NSA Has Keys To Most Internet Encryption
NSA Leak Reporter Says 'U.K. Puppets' Detained His Partner
NSA Has Broken Privacy Rules 'Thousands Of Times Each Year'
Obama To Leno: 'There Is No Spying On Americans'
U.S. Declassifies Documents About Surveillance Programs
US Says It Won't Seek Death Penalty For Snowden
Amendment Limiting NSA Records Collection Fails In The House
Snowden Asks For Temporary Asylum In Russia, Says Lawyer
WILL Highlights
The hidden racism of young white Americans
From PBS NewsHour: Look at data that shows the percentage of whites in each age group espousing racist ideas.
WILL-AM and reporting partners win AP Awards
A series by Illinois Public Media reporting partners won an AP award for Best Investigative Report. Former IPM reporter Sean Powers was named Best Reporter.
PBS is America's most trusted institution
Annual survey shows PBS and member stations are trusted, valued and essential.


text:
i want to change the color of a selected items from a list box control how to do that in windows(Winforms)
Take the 2-minute tour ×
Stack Overflow is a question and answer site for professional and enthusiast programmers. It's 100% free, no registration required.
As far as I know if you want to do that you need to make the ListBox.DrawMode OwnerDrawFixed and add an event handler on to the DrawItem method.
Something like this might do what you want:
Hope it helps James
Assuming you're working with WinForms:
Most controls will have a BackColor and BorderColor property. You could add the


text:
Search Results
The recording of WebWare Part 1 starts at 26:50. This recording of the NetWorks Webinar from 9/28/07 with Gordon Synder and Mike Qaissaunee. They demonstrated WebWare Part 1. These free Webinars provide insight into...
The Net Generation has grown up with information technology. The aptitudes, attitudes, expectations, and learning styles of Net Gen students reflect the environment in which they were raised; one that is decidedly...
Many online calculators require a Java-capable browser. Here's one that doesn't, and will perform over 500 different unit conversions for distance, area, volume, mass, speed, temperature, pressure, energy, power, force,...
Annenberg Media presents a collection of multimedia teaching resources for science, math, art, history, English, and foreign languages. Organized both by level and by subject, the resources provide teaching aids,...
Created by Dr. Hossein Arsham, The Wright Distinguished Research Professor in Management Science and Statistics at the University of Baltimore, this site reveals insights gained by Arsham and colleagues from their...
Manage your resources
Save, organize, and share resources that you find.
Subscribe to bulletins
Automatically be notified about new resources that match your interests.
It's easy, fast, and FREE!
Have a favorite applied math or science site you want others to know about?
SUGGEST a
to add to AMSER


text:
WANTED: Fibre Craft Bed doll pattern
cutepuffykittyNovember 27, 2004
I am looking for a fibre craft bed/pillow doll pattern but I am not sure of the name. It may be called sunflower. It features a yellow dress trimmed in white with sunflowers. If anyone has or even knows the name please let me know. firstname.lastname@example.com
thanks, Charissa


text:
Mary Linsmeier Schools
Preschools Watertown
Preschools Watertown
Mary Linsmeier Schools can be found at S 8th St 415. The following is offered: Preschools. The entry is present with us since Sep 10, 2010 and was last updated on Nov 14, 2013. In Watertown there are 5 other Preschools. An overview can be found here.Published by: Opendi


text:
Intracellular infection of the C. elegans intestine by microsporidia
Balla et al. show that a strain of the nematode Caenorhabditis elegans from Hawaii is able to clear intracellular infection by its natural microsporidian pathogen Nematocida parisii. The top image labels N. parisii inside the C. elegans intestine, using fluorescent in situ hybridization staining the pathogen in red and DAPI staining DNA in blue—lower images show alternate color schemes for the intestinal infection.
Image Credit: Keir Balla
Ambra 2.10.11 Managed Colocation provided
by Internet Systems Consortium.


text:
Sign up for our emails and be the first to
know about special offers, sales,
the latest arrivals and much more!
Your Bag Is Empty.
$4200 $1500
Make the Strokes of Genius Teal Striped Dress your masterpiece, with colorful brushstroke stripes in a rainbow of pretty colors! Soft woven material forms a sexy, paneled bodice with a sweetheart neckline and side cutouts, plus adjustable spaghetti straps that double up in back before connecting to a wide, black elastic band that fastens with four hook-and-eye fasteners. Wide elasticized waistband flows into a gathered skirt with plenty of flare. Invisible back zipper/hook clasp. Fully lined. Model is wearing a size small. Self: 65% Polyester, 35% Rayon. Polyester lining. Hand Wash Cold. Imported.
NEED HELP CHOOSING A SIZE? See measurements & fit info for this garment in the Size & Fit dropdown!
PRODUCT MEASUREMENTS: Compare these measurements to your own body measurements. We measure each item "relaxed" on a flat surface, not stretched on a person's body. It is helpful to consider the material of the item, as some stretchy materials may give an inch or two.
Because sizing and cut will vary between brands, please use this information as a general guide. Use our Size Chart to help determine your size. If you are between sizes or need help finding the proper size, please Chat with a Stylist.
This is a really fun light dress looks just like the photo, not to short.
Very cute dress. Fabric is good, not too thin, which I was worried about because some of LuLu's dresses are see through. Not a problem with this. I think it runs a little small. I usually wear a medium and my measurements are 36/29/38. The large fit perfectly. Even with my belly pooch, the cut outs are strategically placed, so I actually looked slimmer in the waist (yes!). The straps cover up a bra, but I won't be wearing a bra, don't really need one because its a fitted corset style at top. Dress has a slight flare at hip, so if you are hippy, it will disguise. Going to wear with simple white
Great dress for summer. Good material. The back of the dress is really cute
That's a Wrap Blue Long Sleeve Dress
$49Shop Now
That's a Wrap Neon Yellow Long Sleeve Dress
$49Shop Now
Sign up for our emails and be the first to
know about special offers, sales,
the latest arrivals and much more!


text:
The work load increased the second year, which made the class more difficult than expected, but we all made it through.
Kayt Racz, Communication Studies
In 2012 the college celebrated 175 years as an institution of teaching and learning. Visit the 175th website for more information and to view photos of the events.
Bristly Sarsparilla Aralia Hispida
Ginseng Araliaceae family
No pictures yet.
The leaves are egg-shaped and sharply toothed. They are compound leaves. The lower portion of the stem is bristly.
Flower stems are seperate from leaf stems. White flowers are round in an umbel shape and extend above the leaves.
Form/habitat: 1-3' in height, and blooms in the summer. These are common flowers found in dry, open woods and clearings.
The fruit is in the form of dark purple berries.
Click here to return to the Spring Wildflower index.
Click here to return to the Virtual Herbarium Home Page.
Colby-Sawyer College
541 Main Street
New London, NH 03257
(603) 526-3000


text:
415 E Norfolk Ave
Norfolk, NE 68701
Category: Brakes|Auto Repair|Mufflers and Exhaust Systems
Carrental by outspken_tigress - 12/15/2011
When my truck had to go in the shop last minute I called and told them what was going on and asked if they could come get me so I could rent a car from them. They said no problem and were there in a few minutes. They provided great services and were very resonable in price! The day my truck was done they gave me a ride back to the shop to pick up my ride! Thanks to the wonderful people @ Avenue Muffler~Bobbi Jo~ ps. ask for the pink scooter,lol
DexKnows Mobile profile for Avenue Muffler in Norfolk, NE


text:
Will an empty room hurt sale of home?
We live in a traditional 2 story, about 10 years old. On the main floor is kitchen, family room, formal dining, formal living, laundry and half bath.
Currently, we never use the formal living room and it is empty. It is visible and basically off the foyer as in many traditional 2 story homes. It is basically one long room open to the formal dining room. So when you walk in the formal living room off the foyer, you can see the formal dining room.
Will the empty formal living room hurt sale of this house? We don't really want to spend money on furniture that we won't be able to use in our next house, but if it would help sell, we would do it.
What do you think?
I would dress up the room, but not with furniture. An excellent paint color, maybe crown molding, a simple window treatment - white cotton sheers pulled back with a colorful tie, a beautiful torchiere lamp that throws light onto the ceiling, maybe a tree in a corner with an uplight. The flooring, walls and baseboards need to be immaculate.
The big issue for an empty room is lighting. You don't want it to appear dark and gloomy.
I think buyers would realize you're still in the home and not partially moved out because of all the other furniture in the home. I agree with graywings, the room needs to be immaculate and well lit, and as warm and inviting as an empty room can be. A fresh coat of a warm paint will help to do that. Don't present it as a sterile white box.
The room already has warm paint on the walls and window treatments and a big picture window. I could add a lamp for lighting. Thanks for your thoughts.
Do you have a few pieces of furniture that could be moved into this room? Maybe a desk or chest of drawers and a couple of chairs with a small table between them? It doesn't need a lot of furniture but I think a few pieces would help. And yes, it needs nice paint and good lighting.
I agree that it can be sold empty but I think if every other room has furniture then having the livingroom empty will look uninviting. And it is the first room people see when they walk in, too.


text:
Oaks Gateway on Palmer
Situated in South Townsville, Oaks Gateway on Palmer is on a river and close to ReefHQ Aquarium, Magnetic Island Ferry Terminal, and Castle Hill. Additional area attractions include Cluden Racecourse.
Hotel Features.
Oaks Gateway on Palmer has an outdoor pool and a fitness center. Public areas are equipped with wireless Internet access (surcharges apply). Additional amenities include tour/ticket assistance, laundry facilities, and dry cleaning/laundry services. Complimentary self parking is available onsite for guests.
Rooms open to balconies. The 92 air-conditioned guestrooms at Oaks Gateway on Palmer include hair dryers and irons/ironing boards. Wireless high-speed Internet access (surcharge) is provided.
The room was everything we needed. There was nothing bad or in poor quality at our hotel…
Had a great stay at Oaks on Palmer. Great room, comfortable, great location near a lot of…
Enter dates to check prices
Hotel Info: 866-539-8117from $98
- Standard Room
- Standard Apartment, 1 Bedroom
- 72 Hr Sale - 2 Bedroom Apt. (Unserviced)
- Standard Room
- Standard Apartment, 2 Bedrooms
- Standard Apartment, 2 Bedrooms
- 72 Hr Sale - Standard Room (Unserviced)
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 92 rooms
- This hotel is arranged over 9 floors
- Check-in time starts at 2 PM
- Check-out time is 10 AM
Required at check in
- Credit card deposit required
- Government-issued photo ID required
Travelling with others
- Pets not allowed
- WiFi in public areas *
- WiFi and wired Internet access in rooms *
- Free self parking
In the hotel
- Outdoor pool
- Fitness facilities
- Front desk (limited hours)
- Tours/ticket assistance
- Dry cleaning/laundry service
- Laundry facilities
- Luggage storage
- Year Built 2009
- Elevator/lift
In the room
- Climate control
- Air conditioning
- Iron/ironing board
- Balcony
- Private bathroom
- Hair dryer
- WiFi (surcharge)
- Phone
- Refrigerator
Oaks Gateway on Palmer's small print
Also known as
- Oaks Gateway on Palmer
- Oaks Gateway on Palmer Townsville
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Mandatory fees
Deposit: AUD 150 per stay
Optional extras
Onsite credit card charges are subject to an extra charge
Rollaway beds are available for AUD 44.00 per night
Cribs/Infant beds are available for AUD 20.00 per night
High-speed Internet access (wired) is available in guestrooms for AUD 18.00 per 24-hour period (rates may vary)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
So I've added protein shakes to my diet (I'm not BFing) so I can build muscle and burn more fat.. how often should I drink them? I can't find the answer anywhere on the container..
Protein Shakes
Posted 09/24/2009
Kalvin Davis * July 3, 2009 * 9lb * 22in
Comments (2)
Posted 09/29/2009
it usually depends on what type of protein shake it is. A lot of times it is a really good idea to follow up a workout with a protein shake to help heal/build that muscle. Other than that just look at calories and figure out where to add it in instead of drinking/eating something else that would not be as good for you. I always have a hard time getting the protein in...i am such a carblover
mother of my sweet twins born June 12, 2009
Posted 09/30/2009
I'm breastfeeding but I've been substituting a special K protein shake for my lunch. I rarely finish them because they're very filling which is good.
Momma to Julien Luca born 6/27


text:
Tuesday, October 12 2004
Drug Wars: The Political Economy of Narcotics by Curtis Marez
You don't always have to agree with Marez's rigid Neo-Marxist critical methods to appreciate the value of this detailed historic-cultural study of the blatantly racist, imperialist roots of today's 'war on drugs'.
Crimes Against Nature: How George W. Bush and His Corporate Pals Are Plundering the Country and Hija
Kennedy details the extraordinarily close ties between Bush's environmental policies and the energy interests which have helped him raise unprecedented amounts of money for his campaigns.
And It Don't Stop!: The Best American Hip-Hop Journalism of the Last 25 Years by Raquel Cepeda
A much more interesting anthology might have scrapped the omnibus approach in favor of a different overarching idea.
Wednesday, October 6 2004
The Tearjerker by Daniel Hayes
Hayes postulates writing as an act of timidity and distance, a profession chosen by those who want to recreate excitement rather than experience.
Blinking with Fists: Poems by Billy Corgan
As lyric poems, however, without the support of a band, it's just totally high school, totally amateur, totally naive, and not in the good way.
After by Claire Tristram
After quickly became -- and will hereafter be read as -- a post-Abu Ghraib novel, which burdens it with implications that Tristram could never have predicted.
Tuesday, September 28 2004
The Suburban You: Reports From the Home Front by Mark Falanga
Mark Falanga's book is a non-fictional, thesis-free, made-for-TV, ADD-approved examination of American suburban life.
Seeking Salamanca Mitchell by Kenji Jasper
It is fiction for our times that expertly illustrates the dualism (hustling ambition + layered versatility) of an important sect of Generation Xers.
The Pagan Christ: Recovering the Lost Light by Tom Harpur
By representing both our divine and our human natures, Horus is Everyman and Everywoman; his story is the Gnostic story of human consciousness.
Dylan's Visions of Sin by Christopher Ricks
Ricks takes displaying linguistic dexterity and literary education several horizons too far -- far too often, this loses Dylan and it loses readers.
Tuesday, September 21 2004
Since You Ask by Louise Wareham
In recounting Betsy's dynamic and destructive connections, Wareham has crafted a novel that portrays a complicated character and her multifaceted mind with deep empathy.
Moscow 1812 by Adam Zamoyski
Zamoyski blames Napoleon's tactical leadership with the campaign's failure, and the list of errors the author attributes to the emperor looks surprisingly like the kinds of mistakes that continue to doom military campaigns to this day.
Hoax: Why Americans are Suckered by White House Lies by Nicholas von Hoffman
Von Hoffman rings the death knell for the 'American Century', claiming that despite its current braggadocio and so-called victories in Afghanistan and Iraq, the US has failed in its effort to bring any stability to the region.
Tuesday, September 14 2004
Wake Up, Sir! by Jonathan Ames
Blair is an endearingly unsuccessful human being -- and writer-- out to craft the Great New Jersey Novel, thinking the Great American Novel beyond his reach.
So What! The Good, The Mad, and The Ugly by Steffan Chirazi
Unvarnished, revealing, annoying, inspiring, and illuminating, the voices of Metallica in this book reach far beyond Hetfield's usual growl on his vocal recordings.
Some of My Best Friends: Writings on Interracial Friendships by Emily Bernard
It is a pressure cooker situation. Many of the essays are filled with anger, resentment, confusion, misunderstanding, and contradictions.
How I Paid For College: A Novel of Sex, Theft, Friendship and Musical Theater by Marc Acito
Marc Acito, who has been called the 'gay Dave Barry,' understands sexual confusion and explores it subtly and lightly, avoiding a heavy-handed approach.
Tuesday, August 31 2004
Judging Thomas: The Life and Times of Clarence Thomas by Ken Foskett
The two most highly combustible issues in America -- race and sex -- had been doused with gasoline and set afire.
I Dream of Microwaves by Imad Rahman
At best, such work is insightful; cross-breeding makes for more ingenious and unique prose. At its worse, bad multicultural literature is just bad writing.
Ghosts of Vesuvius: A New Look at the Last Days of Pompeii, How Towers Fall, and Other Strange Conne
Before we pass judgment on the moral fiber of earlier societies, we must first examine our own regard for humanity, our propensity for cruelty, and our readiness to deal with future disasters.


text:
Dybing 100th
An open house to honor Tillie Dybing on her 100th birthday will be held from 1 to 3 p.m. on Saturday, Aug. 24 at Union Central, 307 Lake Ave., Detroit Lakes.
Tillie was born Aug. 28, 1913.
No gifts please. Cards may be mailed to 307 Lake Ave., #8, Detroit Lakes, MN 56501.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at firstname.lastname@example.com and we can help you.


text:
Dow Chemical Research Engineer Interview Questions
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
Interviews for Top Jobs at Dow Chemical
- Intern (15)
- Research Scientist (12)
- Engineering Co-Op (8)
- Engineering (7)
- Senior Engineer (7)
- Process Engineer (7)
- Senior R&D Engineer (6)
- Senior CHEMIST (5)
- Research Chemist (5)
- Chemical Engineer (5)
- Maintenance Engineer (5)
- Research Engineer (4)
- Mechanical Engineer (3)
- Process Operator (3)
- Production Engineer (3)
- Research Specialist (3)
- Scientist (3)
- Senior Analytical Specialist (3)
- Manager (3)
- Reliability and Maintenance Engineer (3)
- Reliability Engineer (2)
- Improvement Engineer (2)
- Senior Research Chemist (2)
- Senior Research Scientist (2)
- Marketing Manager (2)
- Supply Chain Intern (2)
- Operator (2)
- Co-Op (2)
- Chemistry (2)
- Financial Analyst (2)
4 Candidate Interview Reviews Back to all InterviewsSort: Popular Date Difficulty
Research Engineer Interview
It was campus recruiting. The first round was mostly behavioral questions. At the beginning, I was asked to introduce my research for about 3-5 mins. The behavioral questions are standard questions.
- How will you approach others for help? Answer Question
Other Interview Reviews for Dow Chemical
Research Engineer InterviewApplication Details
I applied through college or university. The process took 2 days – interviewed at Dow Chemical in December 2012.Interview Details
The interview process was pretty standard. I gave a research seminar in the morning and then had one on one interviews for the rest of the day. One on one interviews were exhausting, due to the fact that I was the one who would always ask questions, initiate the conversation and so on. Imaging, by the end of the day I almost run out of questions....Reasons for Declining
due to locationDeclined OfferPositive ExperienceAverage Interview
Research Engineer InterviewApplication Details
I applied through an employee referral. The process took a day – interviewed at Dow Chemical in November 2012.Interview Details
This is an on-site interview for a PhD level research Engineer in Hydrocarbon R&D group. I got this opportunity from an employee referral. The process started with a 45-60 min long presentation on my own graduate research, followed by 6-7 1:1 interviews with the research scientists/engineers. It also included a dinner the night before, a lunch during the interview, a lab tour and an HR wrap-up. The whole process was from 8AM to 3:30PM.Interview Questions
No OfferPositive ExperienceAverage Interview
- Most of the questions are typical behavior questions that can be found on the internet. The interviewers asked a lot about my ability to work in a team-working and my research interests beyond my own field. View Answer
Research Engineer InterviewApplication Details
I applied through an employee referral. The process took 6+ months – interviewed at Dow Chemical.Interview Details
Lengthy +6months
Half of the interviewers unqualified to evaluate your expertise
No HR response for extended periods
Interviewers unprepared to answer what your job profile will consist - only direct reporting supervisor is aware.Interview Questions
Accepted OfferPositive ExperienceAverage Interview
- None out of expertise / basic personal details Answer Question


text:
I have some Perl code which has file glob operation.
$file1 = @ARGV[0];
@res1 = glob "$file1*";
I want the whole absolute paths to be reflected when i glob the files, not just the file names which is the case currently in my code.
e.g. when I do glob "*.pdf" i need the absolute paths of the pdf files to be matched and returned to my array variable by glob.
I tried using module use File::Basename; but that seems to be used for parsing a file path into directory, file name , suffix.
How do I get this effect.


text:
If you can get a legacy Kaoms, I would. I think a Legacy one is like +1500ish HP over a normal one at lvl 100 and some HP nodes.
Can you get an item with 2% mana leech so that mana isn't a problem?
10k is not bad solo (just not so hot in groups -- obviously you can't compete with DPS glass cannon builds, but such is the life of a tank).
Your tree is fine, other than I wouldn't have gone down the "Thick Skin" route (see my latest tree for reference).
Melee is getting some love in Act 4 -- it will be interesting to see what happens. Apparently crit is getting adjusted some, too.


text: Quick View Growing Up with Autism: Working with School-Age… by Robin L. Gabriels April 25, 2007 | Hardcover Out of stock online used copies from $5.04 Individuals with autism and their caregivers face unique challenges in later childhood and adolescence. This volume translates research on the needs of this population into practical recommendations for clinicians and educators. The book features vivid case examples and an in-depth, reproducible… See Details $83.95 / $79.75 lowest price*, or used from $5.04was $83.95


text:
First Presbyterian Church deacons donate to Churches United
The Deacons of First Presbyterian Church donated $500 to Churches United. Pictured are Churches United secretary Jackie Welle, Deacon Vera Weis and Deacon Cheryl Hiltz, Churches United treasurer. Submitted Photo
Get the full story
Subscribe or Log In
Are you a newspaper subscriber but you don't have a Digital Access account yet? Activate your account.
You will need your subscription account number and phone number. Not sure if you have an account? Email us or call (218) 333-9200 and we can help you.


text:
Make it and take it to go! Perfect for popular water enhancers, powdered beverages, and iced coffees and teas, this NEW Shake & Go tumbler provides an easier, no-mess way to prepare and enjoy your favorite drinks. The patent-pending AUTOCLOSE technology means 100% leak-proof shaking and mixing* so you never have to stir with your straw (or finger) again. Our sweat-proof double-wall design and shatter-resistant, BPA-free Tritan provides a better way to enjoy your favorite drinks at home or on-the-go. Simply make it, shake it and take it. Fits under most single-serve brewers. Durable, shatter-resistant, BPA-free Tritan repels stains and odors. Top-rack dishwasher safe. Dimensions:3.5" Wide x 8.5" Tall (11" tall with the straw). 16oz.
Number of Pieces: 1
Features: BPA Free, Straw, Double Wall Construction, Leak-Proof Design
Capacity (volume): 16.0 Oz.
Container Material: Polypropylene
Lid Material: Polypropylene
Care and Cleaning: Dishwasher-safe Top Rack Only
Dimensions: 11.0 " H x 3.0 " W x 3.0 " D
Weight: 0.6 Lb.
other Info.
- Imported


text:
I'm 39 and finding myself starting over again. I like to go out very once in awhile but I really like getting together with good friends. I have a daughter who will turn 6 in Feb.. I'm a pretty laid back guy. I grew up on Florida and still prefer shorts & and T-shirt to getting all dressed up. My daughter & I love LSU sports, playing outside, & getting together with friends. I want to get to know someone first and we'll take it from there. I can see myself getting married again and even having another child; but I want to know I found the right woman first! If you want to know more, just ask!
Join OkCupid
Find better matches with our advanced
Find better matches with our advanced
matching system
—% Match
—% Enemy
43 • Denham Springs, LA • Man
I'm looking for
- Women
- Ages 28–40
- Near me
- Who are single
My details
- Last online
- Dec 16, 2014
- Orientation
- Straight
- Ethnicity
- White
- Height
- 6′ 0″ (1.83m)
- Body type
- Average
- Diet
- Mostly anything
- Smokes
- No
- Drinks
- Not at all
- Drugs
- Never
- Religion
- Christianity
- Sign
- Virgo
- Education
- Dropped out of university
- Job
- Sales / Marketing
- Income
- $40,000–$50,000
- Status
- Single
- Type
- —
- Offspring
- Has a kid
- Pets
- —
- Speaks
- English
Similar Users
My self-summary
Write a little about yourself. Just a paragraph will do.
What I'm doing with my life
Don't overthink this one; tell us what you're doing day-to-day.
I'm a Sales Consultant for a home improvement company. When I'm not working, I'm either spending time with my daughter or playing volleyball in one of a couple of leagues I'm in.
I'm really good at
Go on, brag a little (or a lot). We won't judge.
I'm a pretty good cook, not too bad at pool, and kicking back on a beach.
The first things people usually notice about me
I'm an empty essay… fill me out!
Don't know; I never asked anyone.
Favorite books, movies, shows, music, and food
Help your potential matches find common interests.
I don't get to read as much as I'd like. I am a movie guy though, I like just about everything. I'll eat just about anything - I'm not picky.
The six things I could never do without
Think outside the box. Sometimes the little things can say a lot.
My daughter, TV, computer, fax machine, cell phone, and sports talk radio.
I spend a lot of time thinking about
Global warming, lunch, or your next vacation… it's all fair game.
Work. I know; sad but true. Why do you think I'm here?! I'm looking to find some one to spend time with.
On a typical Friday night I am
Netflix and takeout, or getting your party on — how do you let loose?
Usually at home. I work on the weekends.
The most private thing I'm willing to admit
I'm an empty essay… fill me out!
Who's gonna read this? On the advise of counsel.....I'll answer that later.
You should message me if
Offer a few tips to help matches win you over.
your looking for something that could grow into a long term relationship
Connect your existing OkCupid account
Sign in
Welcome Back!
Restore your account to continue meeting new people.
Reset your password
We'll email you a link to reset it.
Email sent!
An email is on its way to . If you don't see it, try checking your Spam folder.


text:
United States / $ (USD)
Judaica, Jewish Gifts, Tallits, Jewish Jewelry, Shofars & more
- Home »
- Judaica »
- Kiddush Cups »
- Small Orange Aluminum Kiddush Cup with Matching...
Small Orange Aluminum Kiddush Cup with Matching Silver Stripe
Share: Send to a friend:Product ID: KDC-AG-69913
This small silver-colored aluminum Kiddush Cup features a single silver stripe near the bottom edge and has a modern shape with slightly curved top edges. Read more
Contact Our Judaica Experts 24/7 1-800-818-8394
For Phone Orders Please Mention: help-phonecode-updating
Live Chat Online
THIS ITEM QUALIFIES FOR FREE SHIPPING With an order of $59 and over
In accordance with our shipping policy
People who bought this item also bought:
- 14 cm. Crystal Shabbat Candlesticks with Blue Embellishments $97
- Blue and Silver Yair Emanuel Shabbat Tea Light Candle Holder $32
- Waterfall Canvas by Duby Tal $100
- Yair Emanuel Laser Cut Dreidel with Hebrew Text and Red and Gold Decorations $11
- Star of David Pendant with Center Design & White Zircon Stones $10
- Challah Knife for Shabbat with Translucent Handle and Red Accents $27
- Small Pistachio Triangle Pomegranate Honey Dish by Adi Sidler $26
- Messianic Pendant in Gold Plated Embellished with Zircon Stones $62
- Natural Stone Hook Earring from Amaro Jewelry $30
- Two-Tone Wood Mezuzah with Pewter Divine Name in Hebrew and Jerusalem Walls $16
- Chai Tallit with Purple Stripes, Hoshen, Pomegranates and Star of David $154
- Embroidered Tallit and Tefillin Bags with Hebrew 'If I Forget Thee, O Jerusalem' Embroidery $68
Product Description
This handsome Kiddush Cup is made from anodized aluminum and features a simple shape. The cup has a flat bottom, cylindrical sides and a top edge with a slightly rounded lip. The bottom of the cup is adorned with a matching silver stripe. This cup can be used to drink Kiddush wine or any other drink.
This item is an ideal holiday gift idea!
General Information
Material Aluminium
Dimensions 4x7cm
Estimated processing time:
3-5 Business Days.Learn More
Similar Products
- $167 Sterling Silver Kiddush Cup with Hebrew Text and Chuppah Scene View Product
- $160 Silver Sleek Shabbat Kiddush Cup with Hebrew "HaGafen" Writing View Product
- $149 Sterling Silver Kiddush Cup Plate with Rose Design View Product
- $170 Simply Modern Kiddush Cup View Product
- $150 Silver Plated Kiddush Cup and Heptagon Saucer Set – Diamond Net View Product
- $162 Sterling Silver Plated Kiddush Cup with Mirrors and Floral Patterns View Product
- $162 Sterling Silver Plated Kiddush Cup with Beads, Squares and Engraved Lines View Product
- $156 Sterling Silver Plated Kiddush Cup with Complex Floral Pattern and Stem View Product
- $156 Sterling Silver Plated Kiddush Cup with Stylized Vines and Matching Saucer View Product
- $170 Small Silver Aluminum Kiddush Cup with Matching Silver Stripe View Product
Recommended Products
- $79 Israel Leaders Action Figure Set View Product
- $13 Kids' IDF T-shirt View Product
- $7 Jerusalem Landmark Oven Mitt and Potholder View Product
- $75 Shell Necklace with Star of David in Sterling Silver View Product
- $56 Traditional Ashkenaz Ram Horn Shofar View Product
- $47 Jerusalem Menorah View Product
- $16 Views of Israel Calendar View Product
- $20 Lions of Judah White Long Sleeve with Star of David View Product
- $6 Birthday Card for 18th Birthday View Product
- $10 Traditional Wax Havdalah Candle Four Pack with Traditional Design View Product
Customers Reviews
(No Reviews) 0
Popular Searches that include this item:
Multiple Shipping Methods!
Choose among a variety of convenient shipping methods.Learn more!
24/7 Customer Service
- Contact Our Judaica Experts 24/7 1-800-818-8394
- Live Chat
Judaica Products
Yair Emanuel
View all Yair Emanuel»
- New Judaica Brands
- New Candlesticks & Candles
- New Havdalah Sets and Candles
- New Kiddush Cups
- New Kippot
- New Mayim Achronim
- New Menorahs
- New Mezuzahs
- New Shofars
- New Sterling Silver
- New Synagogue Items
- New Tallit Items
- New Tefillin
- New Tzedakah Boxes
- New Tzitzit
- New Washing Cups
- New Yair Emanuel
Jewish Occasions
- New Shabbat
- New Hanukkah
- New Passover
- New Purim
- New Rosh Hashanah
- New Sukkot
- New Wedding
- New Bar Mitzvah
- New Bat Mitzvah
- New Bris
- New Israeli Independence Day
From Israel
Body Care & Dead Sea
View all Body Care & Dead Sea»
- New Israeli T-Shirts
- New Israeli Kosher Food
- New Israeli Artists
- New Books
- New CDs
- New DVDs
- New Hebrew Learning
- New Military Surplus
- New Israeli Cleaning Supplies
- New Israeli Brands
- New Israel Coins & Medals Corp.
- New Israel Museum Products
- New Megemeria by Yvel
- New Body Care & Dead Sea
Jewish Jewelry
- New Our Jewelry
- New Necklaces and Pendants
- New Bracelets
- New Rings
- New Earrings
- New Brooches
- New Accessories
- New Kabbalah Jewelry
- New IDF Jewelry
- New Name Jewelry
- New Choshen Jewelry
- New Magic Touch Jewelry
- New Adina Plastelina
- New Marina Jewelry
- New Ben Jewelry
- New Jerusalem Pearl Collection
- New Megemeria by Yvel
Jewish Home
- New Apparel
- New Blessings
- New Bookmarks
- New Children's Items
- New Decorative Plates
- New Figurines
- New Hamsa
- New Home Decor
- New Jewish Calendars
- New Jewish Pictures
- New Kitchen
- New Linens
- New Shot Glasses
- New Snow Globes
- New Stationery
- New Chabad
Featured Items
- New Popular Passover Items
- New New Arrivals
- New Artist of the Month-Megemeria
- New Souvenirs From Israel
- New Rockets into Roses
- New Ben Jewelry
- New Photographs by Duby Tal/Albatross
- About World of Judaica
- About Us
- Why Buy World of Judaica
- Contact us
- Customer Testimonials
- Coupons and Discounts
- Learn About Judaism
- Website Policies
- Privacy Policy
- Terms of Use
- Secure Shopping
- Return Policy
- Warranty
- Sitemap
- Newsletter Sign Up Now!
- United States / All prices in $ (USD)
- Change your country or language
- Change selected currency
© 2008-2015, World Of Judaica


text:
Decorative front door flags
susandail_mMay 5, 2014
Are these flags, which were so popular "back in the day" still popular?
I just bought a new garden flag to hang at the entrance to our front walkway yesterday. Flags, whether hung on the house, or in the garden are a nice way to welcome people. Our house has little/no visibility from the street, so I always change the walkway flag seasonally.
When we moved from New Jersey in 2006, it seemed like every home still had a flag hung at the front entrance. We have recently moved back to the East Coast and I don't see many at all. We are in Maryland, outside DC. Maybe it's a regional thing. I'll keep checking the neighborhoods as I travel around our new area.


text:
The compound represented by the formula; ##STR1## [wherein R1 stands for hydrogen, methoxy or trifluoromethyl; R2 and R3, being the same or different from each other, stand for hydrogen or methyl; R4 stands for optionally substituted hydrocarbon residue; and n denotes 0 or 1] or a salt thereof show excellent antibacterial activities, against the genus Campylobacter, especially against Campylobacter pylori, and they are used for preventing or treating infectious diseases caused by the said bacteria.
1. A method for combatting infectious diseases caused by the genus campylobater which comprises administering to a mammal in need thereof an antibiotially-effective amount of a compound of the formula ##STR3## wherein R1 stands for hydrogen, methoxy or triflouromethyl; R2 and R3, being the same or different from each other, stand for hydrogen or methyl; and R4 stands for optionally substituted hydrocarbon residue and n denotes 0 or 1, or a pharmacologically acceptable salt thereof.
2. A method according to claim 1, wherein R1 is hydrogen.
3. A method according to claim 1, wherein R3 is hydrogen.
4. A method according to claim 1, wherein R4 is fluorinated alkyl group.
5. A method according to claim 1, wherein R4 is fluorinated alkyl group.
6. A method according to claim 1, wherein R1 is fluorinated alkyl group.
7. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,2-trifluoroethoxy)pyrid-2-yl}methylsulfinylbenzimidazole.
8. A method according to claim l, wherein the compound is 2-{3-methyl-4-(2,2,2-trifluoroethoxy)pyrid-2-yl}methylthiobenzimidazole.
9. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyrid-2-yl}methylsulfinylbenzimidazole.
10. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyrid-2-yl}methylthiobenzimidazole.
11. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3-tetrafluoropropoxy)pyrid-2-yl}methylsulfinylbenzimidazole.
12. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3-tetrafluoropropoxy)pyrid-2-yl}methylthiobenzimidazole.
13. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,4,4-hexafluorobutyloxy)pyrid-2-yl}methylsulfinylbenzimidazole.
14. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,4,4-hexafluorobutyloxy)pyrid-2-yl}methylthiobenzimidazole.
15. A method according to claim 1, wherein the compound is 2-(3,5-dimethyl-4-methoxypyrid-2-yl)methylsulfinyl-5-methoxybenzimidazole.
This invention relates to a pharmaceutical composition containing pyridine derivatives, known as a compound having anti-ulcer activity, useful as antibacterial agent and a method for preventing or treating infectious diseases caused by the genus Campylobacter by administering the pyridine derivatives.
Bacteria belonging to the genus Campylobacter have been known as possible causes of gastro-intestinal disorders of animals For example, Campylobacter pylori is isolated with high frequency from the gastic mucosa of patients suffering from gastritis and peptic ulcer, and, several investigators have suggested that this organism might participate in the pathogenesis of these diseases. (cf: The Journal of Infectious Desease, Vol. 153, pp. 664-669, 1986 and The Lancet, May 27, pp. 1167-1168, 1989). Furthermore, the close association between the presence of Campylobacter pylori and duodenal ulcers has been also suggested (cf: Digestion, Vol. 37, pp. 16-30, 1987).
Until now some studies dealing with the effectiveness of antibiotics, bismuth citrate, anti-ulcer agent (cimetidine, ranitidine, etc.) or related compounds in the treatment of the infectious diseases associated with the genus Campylobacter have been reported. (cf: Journal of Antimicrobial Chemotherapy, Vol. 17, pp. 309-314, 1986), but no practical use for them has been realized yet.
As mentioned above, no clinically effective pharmaceutical agents against bacterial infections due to the genus Campylobacter have been brought into existence. The present invention provides an antibacterial agent effective to the genus Campylobacter.
The present invention relates to:
1. An antibacterial composition which contains an effective amount of a compound of the formula (I); ##STR2## wherein R1 stands for hydrogen, methoxy or triflouromethyl; R2 and R3, being the same or different from each other, stand for hydrogen or methyl; and R4 stands for an optionally substituted hydrocarbon residue and n denotes 0 or 1, or a pharmacologically acceptable salt thereof, and pharmacologically acceptable carriers.
2. A method for preventing or treating infectious diseases caused by the genus Campylobacter, which comprises administering a compound of the formula (I) or a pharmacologically acceptable salt thereof.
The composition according to the present invention shows excellent antibacterial activities, against the genus campylobacter, especially against Campylobacter pylori, and they are used for preventing or treating infectious diseases caused by the said bacteria.
In the compound (I), preferable examples of the hydrocarbon residue in the optionally substituted hydrocarbon shown by R4 include 1-6 C straight-chain or branched alkyl groups, 2-6 C alkenyl groups and alkynyl groups; the alkyl groups are exemplified by methyl, ethyl, propyl, isopropyl, butyl, 1-methylpropyl, 2-methylpropyl, t-butyl, pentyl, 2-methylbutyl, hexyl, 4-methylpentyl, etc.; the alkenyl groups are exemplified by vinyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 3-methyl-2-pentenyl, 4-methyl-3-pentenyl, etc.; the alkynyl groups are exemplified by ethinyl, 2-propinyl, 1-methyl-2-propinyl, 2-butynyl, 3-butynyl, 1-methyl-2-butynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 2-methyl-3-pentynyl, 2-hexynyl, etc. As the substituents, mention is made of fluorine and 1-3 C alkoxy groups. The number of substituents ranges from 1 to 9, in the case of fluorine, and the number is 1 or 2, in the case of alkoxy groups. Examples of thus substituted compounds include 2,2,2-trifluoroethyl, 2,2,3,3,3-pentafluoropropyl, 2,2,3,3-tetrafluoropropyl, 1,1,1,3,3,3-hexafluoro-2-propyl, 2,2,3,3,4,4,4-heptafluorobutyl, 2,2,3,3,4,4-hexafluorobutyl, 2,2,3,3,4,4,5,5-octaflouropentyl, 2,2,3,3,4,4,5,5,5-nonafluoropentyl, cis-2-fluoro-2-butenyl, 2,2,3,4,4-pentafluoro-3-butenyl, 1,1,1-trifluoro-3-pentyn-2-yl, methoxymethyl, ethoxymethyl, propoxyethyl, 2-methoxypropyl, 3-methoxypropyl, 3-ethoxypropyl, 4-methoxybutyl, trans-3-methoxy-2-propenyl, trans-3-methoxy-2-butenyl, 4-methoxy-2-butynyl, 4methoxy-2-butynyl, etc. Among these, fluorinated 2-6 C straight-chain or branched alkyl groups are especially preferable.
The compound (I) can be produced by a known method, for example, the method disclosed in European Patent No. 174726, and methods disclosed in the laid-open official gazette of European Patent No. 268956 and in the laid-open official gazette of British patent No. 2134523, or methods analogous thereto.
Salts of the compound (I) are exemplified by pharmaceutically acceptable ones obtained by a known method (laid-open official gazette of European Patent No. 124495) or methods analogous thereto, such as salts of alkali metal or alkaline earth metal, e.g. sodium, potassium, calcium, magnesium, etc.
The compound (I) shows antibacterial action against the genus Campylobacter, for example, Campylobacter pylori.
In the following, the antibacterial action of the compound (I) is described by way of Experimental Examples.
The minimum inhibitory concentration (MIC) of each compound was determined by the agar-plate dilution method based on the standard method advocated by Japan Society of Chemotherapy [cf: Chemotherapy, Jan. '81, p. 76]. The volume of agar medium per plate was 20 ml. The compounds tested are shown in Table 1.
TABLE 1______________________________________Compound (I)No. R1 R2 R3 R4 n______________________________________1 H CH3 H CH2 CF3 12 5-OCH3 CH3 CH3 CH3 13 H CH3 H CH2 CF2 CF3 14 H CH3 H CH2 CF2 CF2 H 15 H CH3 H CH2 (CF2)2 CF2 16 H CH3 H CH2 CF3 07 H H H iso-butyl 08 5-CF3 H H iso-butyl 09 5-CF3 H H iso-propyl 010 5-CF3 H H CH2 CH═CH2 011 5-CF3 H H CH2 C.tbd.CH 012 H CH3 H CH2 CF2 CF2 H 013 H CH3 H CH2 CF2 CF3 014 H CH3 H CH2 (CF2)2 CF2 0______________________________________
Each of the test compounds was dissolved in dimethylsulfoxide at a concentration of 80 mg/ml or 40 mg/ml, and diluted 10 times with sterile distilled water. Furthermore, the aqueous solution of 8 mg/ml or 4 mg/ml was diluted serially 2-fold with sterile distilled water. To 2 ml of the diluted solution was added 18 ml of Brucella agar (BBL Microbiology Systems, Becton Dickinson and Co., Cockeysville, Md. 21030) containing 7% defibrinated horse blood (manufactured by Nippon Bio-supp. Center) and mixed well.
Test strains frozen at -80� C. in Brucella broth (BBL) containing 10% horse serum were thawed and inoculated on a Brucella agar slant medium containing 7% defibrinated horse blood. The medium was incubated anaerobically at 37� C. for 3 days in a jar containing a piece of sponge sufficiently impregnated with water and Campy Pak� (BBL).
The organisms grown on the slant medium were collected and suspended in a Brucella broth to correspond to the turbidity of about 108 CFU/ml of common bacteria. One platinum loop of inoculum was streaked on the medium plates for determination. The plates were incubated under the same conditions as described above. After three-day incubation, the growth of bacteria was observed with naked eyes, and MIC (unit:μg/ml) was determined. The results are shown in Table 2 and Table 3.
TABLE 2______________________________________Test strains *Compound A B C D E F G______________________________________1 12.5 6.25 6.25 6.25 6.25 6.25 3.132 25 25 12.5 12.5 25 25 12.53 3.13 6.25 3.13 3.13 3.13 1.56 6.254 1.56 6.25 6.25 1.56 1.56 0.78 6.255 1.56 3.13 1.56 1.56 1.56 1.56 6.25______________________________________
TABLE 3______________________________________Test strains *Compound A B C D E F G______________________________________6 6.25 12.5 6.25 3.13 12.5 25 6.257 12.5 12.5 12.5 12.5 12.5 12.5 12.58 12.5 12.5 12.5 12.5 12.5 12.5 12.59 12.5 12.5 12.5 12.5 12.5 12.5 12.510 25 25 25 25 25 25 2511 12.5 12.5 12.5 12.5 12.5 12.5 12.512 1.56 0.78 1.56 1.56 1.56 1.56 0.7813 1.56 1.56 1.56 1.56 1.56 1.56 1.5614 3.13 3.13 3.13 1.56 1.56 3.13 1.56______________________________________ * Test strains A: C. pylori NCTC 11916 B: C. pylori NCTC 11637 C: C. pylori PCL 56 D: C. pylori CPY 00111 E: C. pylori KS 13 F: C. pylori CLO 1 G: C. pylori CLO 6
As is clear from Table 2 and Table 3, compounds 1 to 14 respectively showed antibacterial activities against the genus Campylobacter. And, the derivatives [R4 of the Compound (I) is a fluorinated alkyl group] (compounds 1, 3, 4, 5, 6, 12, 13 and 14) showed stronger antibacterial activity when compared with other derivatives.
Antibacterial activities of some compounds of the present invention against aerobic common bacteria were examined.
MICs (unit: μg/ml) of the test compounds, i.e. compounds 1, 2 and 6 employed in Experimental Example 1, were determined by the standard agar-plate dilution method of Japan Society of Chemotherapy. The results are shown in Table 4.
TABLE 4______________________________________ CompoundTest strains 1 2 6______________________________________S. aureus FDA 209P >400 >400 >400S. aureus 308 A-1 >400 >400 >400S. aureus 1840 >400 >400 >400S. aureus N-241 >400 >400 >400S. aureus J-108 >400 >400 >400S. aureus P 114 >400 >400 >400S. aureus C 260 >400 >400 >400S. pyogenes E-14 >400 >400 >400S. pyogenes S-8 >400 >400 >400S. mitis America >400 >400 >400S. faecium IFO 3128 >400 >400 >400S. pneumoniae Type 1 >400 >400 >400C. diphtheriae Tront >400 >400 >400E. coli NIHJ JC-2 >400 >400 >400E. coli 0-111 >400 >400 40oE. coli T 7 >400 40D >400C. freundii IFO 12681 >400 >400 >400 C. freundii TN 474 >400 >400 >400K. pneumoniae DT >400 >400 >400K. oxytoca TN 1711 >400 >400 >400E. cloacae IFO 12937 >400 >400 >400E. cloacae TN 583 >400 >400 >400S. marcecens IFO 12648 >400 >400 >400S. marcecens B 315 >400 >400 >400P. vulgaris IFO 3988 >400 >400 >400M. morganii IFO 3168 >400 >400 >400P. aeruginosa IFO 3455 >400 >400 >400P. aeruginosa P 9 >400 >400 >400P. aeruginosa U 31 >400 >400 >400P. aeruginosa GN 3407 >400 >400 >400P. aeruginosa B 184 >400 >400 >400A. calcoaceticus IFO 13006 >400 >400 >400______________________________________
As shown in Table 4, compounds 1, 2 and 6 did not possess at all antibacterial action against the aerobic bacteria. This suggests that the Compound (I) has a selective antibacterial activity against the genus Campylobacter.
Subsequently, the toxicity of the Compound (I) was investigated. Oral administration of compounds 1 and 6 to mice (200 mg/kg) resulted in no dead animals, thus the Compound (I) is low in toxicity.
As described above, the Compound (I) has a strong antibacterial activity against the genus Campylobacter, e.g. Campylobacter pylori; and is of low toxicity. Thus, it can be used for the therapy of infectious diseases due to bacteria belonging to the genus Campylobacter (e.g. diarrhea, food poisoning, etc.) in mammals (e.g. mouse, rat, rabbit, dog, men, etc.). In this case, since the Compound (I) was selectively active against the genus Compylobacter, its administration does not induce the changes in the intestinal flora observed frequently in common antibiotic therapy (e.g. penicillin, cephalosporin, quinolon, etc.). Thus, the treatment with the Compound (I) can not accompany severe risk of undesirable side-effects due to replacement of bacteria (e.g. enteritis, pseudomembranous colitis, etc.). Furthermore, since the Compound (I) shows very unique antibacterial spectrum, its mode of action is considered to be different from that of any of the known antibiotics. Thus, the administration of the Compound (I) is unlikely to induce the acquisition of drug resistance of other species of bacteria or the cross-tolerance with other antibiotics.
When the Compound (I) is used as an antibiotic agent for preventing or treating said infectious diseases, it can be administered orally in a dosage form of capsules, tablets, granules, etc. by formulating with a pharmacologically acceptable carriers, such as excipients (e.g. lactose, starch, sucrose, etc.), disintegrators (e.g. starch, carboxymethyl-cellulose calcium, etc.), lubricants (e.g. magnesium stearate, talc, etc.), binders (e.g. hydroxypropyl-cellulose, hydroxypropylmethyl-cellulose, macrogol, etc.), and so on, and it also can be administered parenterally in a dosage form of injectable solutions which desirably have the concentration of the Compound (I) of 0.1 to 20 mg/ml, particularly 2 to 10 mg/ml.
In the following, the present invention is illustrated in a more concrete manner.
Nonpareils, 1650 g, [sugar core prepared by coating sucrose (75 weight parts) with corn starch (25 weight parts) according to a per se known method, 20-28 mesh] were brought into the CF granulator (CF-360, Freund Industrial Co., Ltd., Japan), and coated, while being sprayed with 1050 ml of a hydroxypropylcellulose solution [2% (w/v)] at 30 ml/min., first with the spraying powder and then with the spraying powder 2, both of which had been prepared by mixing the ingredients listed below, at the rate of 60 g/min. at room temperature with a rotor rotating at 200 rpm, dried in vacuo at 40� C. for 16 hours, and sieved through round sieves, to give spherical granules (14-32 mesh) having a core.
______________________________________[spraying powder 1]compound (1) 450 gmagnesium carbonate 336 ggranulated sugar 297 gcorn starch 300 gL-HPC 354 g[degree of substitution with hydroxypropaxylgroup: 10.0�13.0% (w/w), mean particlesize: not more than 30 μm][spraying powder 2]granulated sugar 300 gcorn starch 246 gL-HPC (the same one as above) 246 g______________________________________
The granules obtained as above, 3,800 g, were brought into a fluidized-bed coating vessel (Ohkawara Co., Japan), subjected to enteric coating by spraying the enteric coating film solution described below at the rate of 50 ml/min. under the controlled conditions of inlet air at 65� C. and material temperature at 40� C., to give enteric coated spherical granules having a core.
The said granules were mixed with talc and light anhydrous silicic acid, then the mixture was filled into No. 1 hard capsules with a capsule filling machine (Parke-Davis & Co., USA) to give capsules.
______________________________________[Enteric coating film solution]Eudragit L30D-55 2,018 g (solid:605 g)talc 182 gpolyethyleneglycol 6000 60 gtitanium oxide 60 gTween 80 27 gwater 4,230 ml[composition in one capsule]enteric coated granules 368.8 mg compound (1) 30.0 mg magnesium carbonate 22.4 mg Nonpareils 110.0 mg granulated sugar 59.8 mg corn starch 36.4 mg L-HPC 40.0 mg hydroxypropylecllulose 1.4 mg Eudragit L30D-50 44.6 mg talc 13.4 mg polyethyleneglycol 6000 4.4 mg titanium oxide 4.4 mg Tween 80 2.0 mgtalc 0.6 mglight anhydrous silicic acid 0.6 mgNo. 1 hard capsule 79.0 mgTotal 449.0 mg______________________________________
The dosage of the capsules is, for an adult man, one capsule after each meal per day.
A 1000 mg quantity of compound (1) was dispersed in distilled water for injection, and 3 ml of 1N-aqueous sodium hydroxide solution was added to dissolve the compound (1), followed by addition of water to make up to the total of 50 ml and sterile filtration by the conventional method. The resulting filtrate was filled in 1 ml portions into vials of a 12 cm3 capacity, followed by lyophilization by means of the conventional technique. The lyophilized powder as contained in vials was dissolved in Solvent A (which was composed of 50 mg of N-methylglucamine, 0.27 ml of 1N-hydrochloric acid and 2 ml of propylene glycol being admixed with ethanol to make up to the total of 4 ml), Solvent B (which was composed of 50 mg of N-methylglucamine, 0.27 ml of 1N-hydrochloric acid, 1.2 ml of polyethylene glycol 400 and 1.2 ml of ethanol being admixed with distilled water for injection to make up to the total of 4 ml), Solvent C (which was composed of 50 mg of N-methylglucamine, 0.27 ml of 1N-hydrochloric acid, 1.2 ml of ethanol and 1.2 ml of propylene glycol being admixed with distilled water for injection to make up to the total of 4 ml) and Solvent D (which was composed of 50 mg of N-methylglucamine, 0.27 ml of 1N-hydrochloric acid and 2.5 ml of polyethylene glycol 400 bing admixed with distilled water for injection to make up to the total of 4 ml), respectively, to perform inspection for their solubilities as well as to conduct investigation into appearance and contents immediately after dissolution and after storage at 25� C. for 24 hours.
The results are shown in Table 5. The lyophilized power showed excellent solubilities in all of these solvents, and were able to be dissolved quickly. In addition to this, the resulting solutions were observed to produce slight changes in appearance immediately after dissolution and after storage for 24 hours, but the changes were found to be so slight that they in no way influence the injectable solution. The solution were found to show no change in the stage of solution while being observed to decrease slightly in content of compound (1).
TABLE 5______________________________________Stability of the lyophilized compound (1)after being dissolved in vials: A B C D______________________________________Solubility Good Good Good GoodpH after 8.7 9.0 9.0 9.0dissolutionAfter dissolution:Appearance Colorless Colorless Colorless ColorlessClarity Clear Clear Clear ClearContent 100% 100% 100% 100%After storage at5� C. for 24 hrs.:Appearance Slightly to lightly green-yellowClarity Clear Clear Clear ClearContent* 97.0% 96.5% 96.7% 96.1%______________________________________ Note, *As measured by use of highperformance liquid chromatography (HPLC), whereby the content determined immediately after preparation was taken as 100.0%. Chromatographic conditions of HPLC: Carrier; Nucleosil 5 C18 (supplied by GasChro Kogyo K.K. of Japan) 4.0 mm � 150 mm Solvent; Methanol:water:triethylamine (60:40:1, pH 7) Detection method; UV spectrophotometry at 285 mm
These solutions can use as injections solutions
Patent Citations
Non-Patent Citations
Referenced by
Legal Events
Original Image