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After Newtown shootings, questions about mental health insurance coverage
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, 2012, 1:25pm EST
In his speech at the memorial service for the Newtown victims, President Barack Obama included mental health in calling for a national response to the massacre. Here are some answers to frequently asked questions about mental health coverage.
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Best Chicken Wings in the U.S.
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Lukshon by Sang Yoon; Culver City, California
Spicy Chicken Pops
At his modern Southeast Asian follow-up to Father's Office, chef Sang Yoon marinates wings in a mixture of ginger, garlic, scallions, onions, Chinese light soy sauce and kecap manis, an intense, dark, sweet Indonesian sauce. The marinated wings are dusted with flour, deep-fried twice in peanut oil and tossed in a sauce made with kecap manis and soy sauce, black vinegar, ginger, garlic, scallions and onions. The fantastically sticky wings are then finished with Yoon's own spicy Sichuan salt. lukshon.com


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Boxing classes in Dubai
We channel our inner Rocky at these classes 1 Comments
In Dubai, boxing is not just a sport for the pros (you've seen the types – burly men and muscular women), but it's increasingly becoming a way for scrawnier folk to keep fit and tone up more effectively than spending hours glumly plodding away on the cross trainer. Some gyms are cottoning onto this trend: one of our favourite new deals comes courtesy of Dubai-based gym Ignite Fitness, which is offering a free pair of boxing gloves to all those who sign up for its Boxfit classes at Riva Beach Club on the Palm and at The Shack gym on Kite Beach. Though if you'd rather just watch punches being thrown, there's always the Dubai Fighting Championship on Friday May 4 at 8pm at the Habtoor Grand Beach Resort & Spa.
Eager to throw a few punches in the name of fitness, I sign myself up for a class at Haddin's Gym in Abu Dhabi. Yet being only 157cm tall and incredibly weak, I'm slightly apprehensive as I arrive for my session. The only thing keeping me happy is that I've managed to colour coordinate my gym outfit.
Michael Haddin, founder and owner of the gym, explains that boxing is a mix of technical skill, grace, speed and aggression. 'When all of these elements come together, this is when boxing is at its best. You need to master the basics to become a great boxer.'
After a quick warm-up of skipping, footwork drills and a few circuits with the dreaded medicine ball, I'm already wondering what I've got myself into. I'm shown how to tie my wraps (long lengths of fabric to protect my wrists and knuckles) and don a pair of boxing gloves; both are provided by the gym, though you're welcome to bring your own.
Michael informs me that boxing is a great full-body workout that's ideal for people who are bored with their gym regime. 'Boxing is great for weight loss and muscle toning, and is also good for people who have issues with their knees and hips or have have trouble running. It's also more fun.'
The first thing I learn is the boxer's stance. I'm told it's the basis for everything else I'll learn, so it's important to take the time to get it right. The theory is to create a stable platform from which I can unleash
my fury, without falling over or being caught off balance. I bend my knees slightly and feel for the floor with my lower body. My torso is turned slightly sideways, presenting a shoulder to my target. The aim is to create a strong base: Michael tells me I should feel that no matter who pushes me, I won't fall over.
'Boxing is great for coordination, balance and core strength,' he explains. 'The rotational movements mean it's a really good abdominal and core workout. If you continue with boxing, you'll lose weight and increase muscle tone, especially in the upper body, and you'll notice an overall improvement in general fitness level.'
Once I've perfected the stance and defence positions, I'm now ready to learn some punching techniques. There are four basic offensive moves in boxing: jab, hook, straight and uppercut. We practise these using
the punch bags, mixing the moves up in quick succession. It's surprising how cathartic the punching feels: when the glove connects perfectly with the bag, the resulting 'thwack' puts a huge grin on my face.
Michael finishes off with a few tips. 'Don't try to go too hard on the punching – focus on technique for the first few couple of sessions. In the long run, this will help you to get a better workout and will also help to prevent injury,' he explains. 'The other key factor is to breathe. Try to get into a rhythm with your breathing – stay relaxed through the shoulders and try not to tense up.'
Michael Haddin runs regular classes at Haddins Fitness Centre, Zayed Sports City, Abu Dhabi, www.haddins.com (02 403 4200). Until April 30, Ignite Fitness in Dubai is offering eight Boxfit sessions for Dhs600, plus a free pair of Everlast 10oz boxing gloves with every sign-up. Riva Beach Club, Palm Jumeirah, and The Shack Kite Beach (04 448 7142).By Angela Beitz
Time Out Dubai,
User reviews:
Posted by: carl robson on 23 Oct ' 12 at 12:59
im a coach coming over to visit how we doing
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text: "The gift moves towards the empty place. As it turns in its circle it turns towards him who has been empty-handed the longest, and if someone appears elsewhere whose need is greater it leaves its old channel and moves toward him. Our generosity may leave us empty, but our emptiness then pulls gently at the whole until the thing in motion returns to replenish us. Social nature abhors a vacuum." – Lewis Hyde


text:
Is the page in question that is asking you to install additional plug-ins the link under the youtube video?If it is, I have no problems clicking on the link and watching the video. I don't see the message that you posted.Below is my list of Plugins that I have enabled•Shockwave Flash 11.5.502.146•Silverlight Plug-In 5.1.10411.0So, do you have either of these? If not, maybe you could try installing them and see if that fixes your issue.--Brian
Sorry if I came across or implied that you are not smart to figure things out.
It's asking which plugin you want to use ... they are already installed.play it in Flash or with Shumway ... choose Shumway
The video was me being humorous, install the add-on to see what is in it, like the Bill.


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Archive: April, 2013
DeSean Jackson: 'Sky's the limit'
Zach Berman, Inquirer Staff WriterIt's common for players to emphasize their excitement when a new coach arrives -- it would be foolish for them to say otherwise -- but DeSean Jackson is one who could especially benefit from the hiring of Chip Kelly. Kelly wants speed and versatility on offense. That's what to expect from Jackson,... Read more
Video: Eagles make draft plans, Chip Kelly makes quarterback plans
Jeff McLane, Inquirer Staff WriterThe Inquirer's Jeff McLane and CineSport's Noah Coslov discuss Geno Smith's visit to the Eagles and what it means for Nick Foles, in addition to Jason Peters and NFL Draft prospects. Read more
Nnamdi Asomugha signs with 49ers after "it just didn't work" in Philadelphia
Zach Berman, Inquirer Staff WriterNnamdi Asomugha's two years in Philadelphia were an unquestioned disappointment, and the Eagles released the former high-priced free agent last month even though they're on the hook to pay him $4 million. Asomugha signed with the 49ers, where he has a chance to resurrect his career in the Bay Area... Read more
Eagles work out Syracuse OL Justin Pugh and other local prospects
Jeff McLane, Inquirer Staff WriterThe Eagles worked out 20 local college prospects on Tuesday, including Syracuse offensive lineman and Council Rock South Rock product Justin Pugh. Pugh is projected by some draft analysts to be selected in the second round later this month. The 6-foot-4, 304-pound prospect played tackle in college... Read more
Brandon Graham does not reveal position, has been preparing for move to OLB
Zach Berman, Inquirer Staff WriterIt's believed that Brandon Graham will be an outside linebacker in the Eagles' new defense. Graham, though, wouldn't confirm that will happen. "I don't know. There's been a lot of talk about a lot of things," Graham said Tuesday. "I don't know where they want to put me at. All I know is whereever... Read more
April 1 arrives, and so do the Eagles
Zach Berman, Inquirer Staff WriterMonday is more than opening day for the Phillies. In a certain way, it could also be considered an opening day for the Eagles, too. Since Chip Kelly was hired, he has been ambiguous and evasive when asked about plans pertaining to specific players because he has not yet had the chance to work with... Read more
Eagles chat with Zach Berman
Philly.com SportsJoin the Inquirer's Zach Berman as he takes your Eagles questions in a live chat, beginning Tuesday at 2 p.m. On a mobile device? Click HERE to join the chat. Read more
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Time, personality and life's challenges prove to be incredibly powerful influences on one's memory of place.
Gobindpal's good faith in God has brought him to where he is today.
Inspired by the Portraits: I am a Believer project, Pat Fennell remembers her Aunt's strength and faith in the face of tragedy.
Lose a friend or lose something much more fundamental to who you are?
Dianne Nazzari thinks helping people can be as easy as asking, how was your day?
"It's something unpredictable, but in the end is right, I hope you had the time of your life."
A glimpse of my visit to Dubbo celebrating the festive season with family.
We run free workshops and can give you skills training and advice on how to create and share your story


text:
Exoplanets Spotted Orbiting Dead Star 76
from the zombie-planet dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
Who the *beep* cares? Seriously....
Because probability dictates a good chance of a Futurama-like world will exist sometime during that span. If you want to be a part get started on your own stasis chamber, now. Don't forget to take a pizza with you, so you'll have something to eat when you emerge.
In the meanwhile, I'm more worried about the survivors of those dead worlds, who are on their way here.
Five billion years from now... oh fuck it, I need a drink.
Sobering up now, this "dead star" is really a white dwarf, isn't it?
Time scales become truly mind-boggling when, after eons as a white dwarf, the nuclear reaction peters out, the "ember" still emitting heat for eons upon eons.
If the proton decays, when the last white dwarf goes out, around 10^14 years from now, the Universe passes from the Stelliferous Era to the Degenerate Era, everything slowly cooling down, matter slowly disintegrating or being sucked into black holes, beyond the point when all free-floating matter has reached 1-to-1 odds of evaporating, roughly 10^40 years from now.
If the proton decays, then the Universe enters the Black Hole Era, when there is no more matter to be sucked into singularities, so that they now begin the excruciatingly slow process of evaporating via Hawking Radiation. The last of the supermassive black holes will have evaporated by 10^100 from now. Then we enter a period of virtual infinity, named the Dark Era, the Universe inconceivably vast and empty and still accelerating.
However, if the proton does NOT decay, circumstances and numbers become even more surreal/nasty, all stars NOT sucked into black holes reach 1-to-1 odds of becoming iron spheres at around 10^1500 years from now. That's right, all baryonic matter in the Universe will have frozen into an iron state. Finally, the last iron star will collapse into a neutron star or black hole at 10^10^76 (ten to the ten to the seventy six).
And that's how thing will end and remain ended.
The goal of Computer Science is to build something that will last at least until we've finished building it.


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Senior Member
Bumps in hope of one day regaining avatar status.
trying to log in now Worre.
The forums would be REALLY enhanced if you could ever get that ingame status light to work, but i believe that's impossible for you, because you don't have access to Riot's server data.
zzz no worre.
playing on mah main.
I bet you could never figure it out.
Lénekton Bot
An Upset Zombie
Mine was working until a few days ago, now instead of icons people have the broken image picture with the ? in the background.
How do I fix this?
Edit: What the heck, my icon is working but nobody else's...
Edit Edit: Now they're completely gone. They randomly go from the broken image to not being there at all.
bump cuz my body is ready
© 2015 Riot Games, Inc. All rights reserved. Riot Games, League of Legends and PvP.net are trademarks, services marks, or registered trademarks of Riot Games, Inc.


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No sim?
Hey it looks like the expanded rosters are set back at 25 again.... IDK why it reverts every season, but its something we need to be aware of i guess. You can set them back to 40 man in the settings. I believe it's on the first page on the left hand side... if not, just look around for it lol.
No worries. You're always welcome back when/if you're ready
Bump. I'm probably gonna have to replace you soon if you dont pick up activity
Anything Jazz could do for Finley? Lakers 1st maybe?
Try uploading again.
Hey, I think Preston Palmeiro would provide a good upgrade for you at 1B. If you're interested, I can move him for Angel Pinto straight up. Or if you'd rather not move him I'm sure we could work something else out. Let me know.
understandable man, real life comes first. i hope everything's ok now. i don't mind simming this week and just keeping to our regular schedule.
Good! Sim today at 5pm EST. Live with all star weekend in Chatzy if we get 15 dc's.
Where are you?
President Of PSD
PSD's Matthew Stafford
Hall of Famer
On-And-Off Leafs Fan
spɹoʍ ɯopuɐɹ ǝɯos pɐǝɹ


text:
Bill Spells Out Lawmakers' Residency Requirements
Posted: 04/25/2014 - The bill passed unanimously Friday specifically spells out the definition of a primary home
Posted: 04/25/2014 - The bill passed unanimously Friday specifically spells out the definition of a primary home
Posted: 04/25/2014 - The legislation cleared the Florida Senate on a 24 to 15 vote Friday. It earlier passed through the Florida House of Representatives.
Posted: 04/24/2014 - Gov. Nathan Deal has signed a bill into law restricting abortion coverage in plans for state employees and those sold on the insurance exchange as part of the federal health care law.
Posted: 04/24/2014 - The Florida Senate has passed a bill that would market the state as a destination for medical procedures to national and international audiences.
Posted: 04/24/2014 - Gov. Nathan Deal has signed into law a bill that would grant amnesty in some cases to those who seek medical help in the event of a drug overdose.
Posted: 04/23/2014 - The Florida Senate has amended a bill from the House that re-works mandatory life sentences for juveniles.
Posted: 04/23/2014 - Killing or injuring a fetus at any stage of development would be a crime under a bill passed by the Florida Legislature.
Updated: 04/24/2014 - This legislation requires the Department of Public Health to establish a Maternal Mortality Review Committee for the purposes of reviewing and developing strategies to prevent maternal deaths in Georgia.
Posted: 04/21/2014 - The Florida House is scheduled to vote on a bill Monday that would make it illegal for insurance companies to deny policies or charge higher rates solely based on gun ownership.
Posted: 04/15/2014 - Today, national aviation organizations applauded Florida Governor Rick Scott for declaring April, "Aviation Appreciation Month."
Posted: 04/14/2014 - Graduate Assistants (GA) in Florida are pushing lawmakers for higher wages.
Posted: 04/28/2014 - The Florida Senate on Sunday offered to back away from a proposal to split up the Florida A&M University and Florida State University.
Posted: 04/11/2014 - The Florida Senate has approved a measure requiring nursing education programs to be nationally accredited within five years of accepting students.
Posted: 04/11/2014 - The Florida House passed a bill increasing the weight threshold for trafficking in oxycodone and hydrocodone in a move to ease what have been called overly harsh sentencing guidelines.
Posted: 04/11/2014 - Florida universities and colleges could keep secret the names of candidates for president under a bill approved by the Florida House.
Posted: 04/11/2014 - The Florida House has passed a bill that would allow the public to carry concealed firearms while evacuating their home during an emergency.
Updated: 04/11/2014 - The Florida House of Representatives today passed CS/CS/SB 188, substituted for CS/CS/HB 195 sponsored by Representative Jake Raburn (R-Lithia), to prevent the collection of certain student-specific data and protect students from identity theft.
Posted: 05/01/2014 - School districts would have to give parents a chance to object to textbooks used in schools under a bill passed by the Florida Legislature.
Updated: 04/24/2014 - Georgia Gov. Nathan Deal says the state and Georgia Regents University will work to help children with seizure disorders get access to a form of medical marijuana.
Updated: 04/11/2014 - State pension strategist Ash Williams says the 87 percent funded current system is one of the nation's strongest because of three main reasons.
Posted: 04/08/2014 - As Republican lawmakers continue to stall any action on raising the minimum wage, Florida Democrats who have joined Senator Dwight Bullard's challenge to live on the meager income for a week will hold a press conference tomorrow to discuss their progress.
Posted: 04/03/2014 - The Florida Senate has approved the so-called `warning shot' bill, which now heads to Gov. Rick Scott to be signed into law.
Updated: 04/24/2014 - State officials say Georgia missed the deadline to clear thousands of backlogged food stamp cases.
Updated: 04/24/2014 - Today, Congressmen Sanford D. Bishop, Jr. (D-GA) and Peter T. King (R-NY) led 94 of their colleagues in standing strong with hundreds of thousands of men diagnosed with prostate cancer every year.
Posted: 04/02/2014 - Remarks Centered on Benefits of Disaster Mitigation


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TUPPER: Another McGovern nudges into SD spotlight
Few candidates in South Dakota are as intriguing right now as Matt McGovern. Granted, he's only running for the Public Utilities Commission, which some voters don't even know exists, but he's got a couple of things going for him.
First, he's a McGovern. Or at least he is of late. He wasn't always that way, as we took great pains to explain at his urging in this Sept. 5 correction:
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New National Historic Landmarks in 10 states
WASHINGTON -- Three Frank Lloyd Wright structures and nine other sites in 10 states have been designated U.S. National Historic Landmarks. The buildings by the famed American architect are the Beth Sholom Synagogue in Elkins Park, Pa., a glazed glass pyramidal tower built in the 1950s; the Aline Barnsdall Complex (Hollyhock House) in Los Angeles, lauded for emphasizing the relationship between the building and the landscape; and Price Tower in Bartlesville, Okla., a cantilevered 19-story building that today houses an arts center, hotel and restaurant. Wright considered Price Tower to be his only skyscraper.
Related Links
National Historic Landmarks homepage
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- Joan Baez, Sly Stone, Steve Martin, Ben E. King -- all honored by the Library of Congress
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- U.S. historian denounces Japanese scholars' statement over wartime sexual slavery
- Timothy V Johnson Named Head of Tamiment Library


text:
List Of Oregon Ballot Measures 2004
A selection of articles related to list of oregon ballot measures 2004.
Original articles from our library related to the List Of Oregon Ballot Measures 2004. See Table of Contents for further available material (downloadable resources) on List Of Oregon Ballot Measures 2004.
- Oregon Grape: Correspondences
- Berberis aquifolium Folk Names: California Barberry, Oregon Grape Root, Rocky Mountain Grape, Trailing Grape, Wild Oregon Grape Gender: Feminine Planet: Element: Earth Deity: Power: Money, Popularity...
Herbalism >> Herbs dictionary O
- Feasts of the Times
- "There are rituals of the elements and feasts of the times." - AL II,36 The Tropical Zodiac, while not shifting with the precession of the Earth like the Sidereal Zodiac, has the charming...
Magick >> Thelema
- Confessions of a TNT Reiki Master
- Last October I began to take Reiki classes. It came on the heels of an energy healing class I had taken that summer at the request of my friend Henry. At the time I had no intention on becoming a healer. Henry, my best friend and soul brother, lives along...
Body Mysteries >> Reiki
- Psychic Protection - Barriers
- Introduction: The countermeasures given in these short articles are extremely basic. They only contain the bare bones of what is necessary to use them. To understand the principles behind these countermeasures, please get a copy of 'Practical Psychic Self-Defe...
Psychic Abilities >> Psychic Protection
- Survivalists' Guide for the New Millennium: Chapter 5
- WHERE I LAY MY HEAD IS HOME A foot and light-hearted I take to the open road, Healthy, free, and the world before me, The long brown path before me leading Wherever I choose. Henceforth I ask not for good fortune, I myself am good fortune, Henceforth I...
Philosophy >> Survivalists Guide for the New Millennium
- Story of the Celts: The Celts of Ireland
- The Celts of Ireland [ 33 ] The Celts arrived in Ireland by 350 B.C (some say earlier) and they thrive there to this day. A claim might be made that the Celtic Irish are among the world's oldest nationality groups. Despite periods when foreigners tried in...
History & Anthropology >> Celtic & Irish
- What is hypnotic trance? Does it provide unusual physical or mental capacities?
- 2.1 'Trance;' descriptive or misleading? Most of the classical notions of hypnosis have long held that hypnosis was special in some way from other types of interpersonal communication and that an induction (preparatory process considered by some to be...
Parapsychology >> Hypnosis
List Of Oregon Ballot Measures 2004 is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, List Of Oregon Ballot Measures 2004 books and related discussion.
Suggested Pdf Resources
- The passage of Ballot Measure 37 by Oregon voters in November 2004 .
- legacy.lclark.edu
- Oregon SOS Home
- people.reed.edu
- Chronology of Successful and Unsuccessful Merit Selection Ballot
- www.judicialselection.us
- A Statistical Analysis of Oregon's Land-Use Ballot Initiatives
- Jun 15, 2008 B. Geography of Support for Land-Use Ballot Initiatives in Oregon From 1976. Through .
- ir.library.oregonstate.edu
- Voting Technology, Ballot Measures and Residual Votes David C
- county level in the 34 states that had issues on the ballot in the 2004 general election. . votes is weaker in places using equipment or ballot features that make it .
- www.umsl.edu
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- List of Oregon ballot measures - Wikipedia, the free encyclopedia
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- ballotpedia.org
- Oregon Property Land Use, Measure 37 (2004) - Ballotpedia
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- Ballotwatch
- Of the forty-two initiatives on the ballot — new laws placed on the ballot by For information on local land and environmental ballot measures see Land Trust Alliance. Post-election Report: Environmental Measures (BW 2004-11) initiatives to appear on the ballot since the first statewide initiative in Oregon in 1904.
- www.iandrinstitute.org
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Metal Gear Solid V: The Phantom Pain | Most Anticipated of 2015
Hideo Kojima was at his tricksiest when he decided to tease and reveal the latest in the Metal Gear Solid series, The Phantom Pain. In a long and convoluted breadcrumb
Kingdom Come: Deliverance – New Details on the Open World Medieval RPG from Warhorse Studios
Kingdom Come: Deliverance is a game firmly rooted in the Middle Ages. "We want to make the game as realistic as possible," Warhorse Studios' social media manager Jiri Rydl tells
The Witcher 3: Wild Hunt | Most Anticipated of 2015
The original Witcher game flew somewhat under the radar on its release in 2007. As a debut title from an unknown Polish developer licenced from a niche but popular fantasy
Battlefield Hardline | Hands-On Preview
Late last week, I got a chance to go hands-on with Battlefield Hardline at Sydney's Justice and Police museum. After signing in, declining the rather vain faux mugshot (the third
The Witcher 3: Wild Hunt – Monster Hunting is Fun | Hands-On Preview
Abs. The first thing I see after booting into The Witcher 3: Wild Hunt is abs. Really really really obvious abs. This glorious washboard belongs to a bathing grey-haired Geralt,
Into the Stars – Explore the Far Reaches of Space and Delay the Extinction of Humanity
In part one, we talked to Ben Jones of Fugitive Games about the team's upcoming space exploration game Into the Stars, and how they decided to make the game what
Meet the Team and Learn the Story Behind the Development of, Into the Stars
Fugitive Games, as they explain on their Kickstarter page for their first project Into the Stars, is "comprised of crafty veterans on the run from traditional development at places like
OnlySP's Game of the Year for 2014 is…
Yeah, okay, we've had the warm-up already, so I'll just tell you – OnlySP's game of the year for 2014 is Dragon Age: Inquisition. In a year full of really
OnlySP's Top 5 Soundtracks of 2014
Nearing the end of the year we always take a look back at the games we played and try to remember them fondly. Some we remember, some we forget. For
OnlySP's Top 5 Game Worlds of 2014
Games are pretty great. They give you things to do, systems to interact with, and places to explore. With 2014 coming to an end, we take a look at the


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How To Root Var. Golden Chalice Cuttings?
Hi. I have grown the green Golden Chalice plant for years,and gotten its cuttings to root 50% of the time by just sticking them in water, then when root buds appeared, put it in a good light soil mix, and I would get a lot more rooted cuttings. BUT I finally have some 'Variegated Golden Chalice Vine' that I want to get cuttings from. It has been a sickly tiny plant for nearly 5 years. This past winter for some reason it decided to finally grow! I now have 3 large long stems, with a bud at each end!!! This is the first time I will see it flower, I dont even know if it is a different flower or not. BUT the plant is definitely different, and I still have little to take risk with, to loose to cuttings. BUT I have 3 long stems, about 2-3 feet long, with one bloom at the end of each stem. I want to get more plants. BUT my water rooting technique is only 50% reliable.
So...does anyone know how to root this thick woody 'vine' and get a better than 50/50 shot at rooted cuttings? Should I try air layering? How is that done? Or is my water way the way to go? I am so excited to get blooms. The blooms even look variegated! So I think I might get some white on my golden blooms! For some reason it decide to grow, from a sickly 1 foot long stick for over 5 years, to 3 long 2-3 foot long stems with a bloom at the end of each stem, this past winter. I am now waiting for the blooms to open, then once they are gone, I want to get cuttings, but I will only have this one shot at it. I will dig up the plant, and hopefully save it, and move it to a more convenient place, to enjoy it. The green variety is like a weed in my yard, I love it! So I would like to move this one nearer to it. But I need more of it. So...any ideas on rooting cuttings of this plant? Thanks for any help.
In the early spring, take soft/semi hardwood tip cuttings about 6 inches long, dip in rooting hormone - preferably liquid.
Immediately pot them into a free draining mix.
Water & mist spray well and allow to drain.
Cover with a plastic bag.
Place on bottom heat source eg. hot water heater, heat mat etc., out of direct sunlight.
The cuttings should have roots in 2 weeks or less.
This method has been used successfully for Brug. sanguinea tip cuttings and that's saying something, because these are difficult to root.
If you take the Solandra cuttings off the top of the plant with a tiny flower bud attached, the cutting won't always abort them and can hold onto them, in a state of suspended animation, until the cutting forms roots, at which point bud development proceeds as normal.
Hope this works for you! Be sure to email me and let me know how it goes.
I root the variegated Chalice same as the standard, just stick a cutting in soil at any time during the warm months (I'm in zone 7). I get pretty much 100% success and I don't bother with rooting hormones or bottom heat. I find them one of the easiest plants to propagate from cuttings.
You want to keep it moist but not wet while it's rooting. You should actually have removed all the large leaves before rooting it. As long as the tip(s) look ok it should be fine. Keep it out of direct sun while it's rooting. It should develop roots within a month.
You can scratch the bark to see if your inground cutting is still alive or just wait and see what happens. Are you going to transfer the potted cutting to the garden? In your climate it should get big in no time. It's such a beautiful plant in bloom, especially in the frost free climates where it gets huge.


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Most vegetable garden diseases can be prevented and controlled. Limit disease damage by identifying diseases quickly and taking action.
Regular visits to the garden will help you spot diseased plants before a disease spreads. Choose the most effective control and then work to prevent future disease outbreaks.
Listed here are 25common vegetable diseases. The list is in alphabetical order.
Listed here are 25
To see common vegetable pests with prevention and control suggestions, click here Vegetable Pest Problem Solver.
To see diseases and pests specific to the crop you are growig, find the crop by name in the Topic Index and click through or check crops by name in the How To Grow archive.
•Description. Fungus disease. Over-winters on infected seed, plant debris, or in the soil. Wet weather promotes growth; optimum growth between 78°F and 86°F.
•Damage. Dark brown circular sunken spot on stems, leaves, pods or fruit. Centers of lesions may ooze pink spore masses. Reddish discoloration of the leaf veins. Leaves may wither and fall. Plant may die back.
•Susceptible plants. Beans, blackberries, cantaloupe, cucumbers, melons, mint, peppers, pumpkins, rhubarb, squash, tomatoes, watermelons.
•Spread.Over-winters in garden in debris of diseased plants. Spread by wind, rain, animals, gardeners, tools. High humidity, high rainfall, and high temperatures encourage spread. Generally found in eastern North America.
•Prevention and controls. Spray or dust with a fixed copper- or sulfur-based fungicide every 7 to 10 days. Remove and discard infected plants. Do not save seed infected planting area; use western-grown seed or seed from areas not infected. Rotate crops. Avoid working in the garden when it is wet which can result in spread of spores. Keep tools clean.
Asparagus Rust
•Description. Fungus disease of massed reddish or black spores grows on asparagus ferns.
•Damage. Tiny, rust-colored spores mass on asparagus ferns. Black spores mass in late summer. Fern growth is retarded. Yield is reduced. High humidity and wet weather encourage spread.
•Susceptible plants. Asparagus.
•Spread. Rust spores are blown by the wind or carried by gardeners, tools, animals or insects. Spores can over-winter in plant debris. Heavy dew and high humidity encourage this disease. Found throughout North America.
•Prevention and controls. Plant resistant varieties. Cut plants to the ground at the end of each season. Remove and destroy plant debris. Keep water off of leaves. Use a preventative sulfur spray or dust every 7 to 10 days until 3 or 4 weeks before harvest.
Bacterial Blight
•Description. Bacterial disease. Most severe where humidity is high for long periods.
•Damage. Beans: large brown blotches bordered with yellow or red on leaves of beans. Water-soaked spots on pods. Pea stems turn purple or nearly black near the ground. Small water-soaked spots on leaves; yellow to brown spots on pods enlarge to reddish color.
•Susceptible plants. Beans, peas.
•Spread.Bacteria enter plants through small openings and wounds. Spread by wind, infected seeds. Over-winters in plant debris. Most severe where humidity remains high for long periods. Found throughout mid-North America, but rarely west of the Rocky Mountains.
•Prevention and controls. Remove infected plants and discard them. Bacterial blight can not be cured. Do not save seed from infected area. Rotate crops. Avoid working in the garden when it is wet; this may result in spread of disease.


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James Stewart +Rating: 4.8
James Stewart was the movies' quintessential Everyman, a uniquely all-American performer who parlayed his easygoing persona into one of the most successful ...more
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Strother Martin +Rating: N/A
A graduate of the University of Michigan, Strother Martin was the National Junior Springboard Diving Champion when he came to Hollywood as a swimming coach ...more
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Born Dawn Bethel, North began dancing professionally at age 10 and, during her teens, modeled and danced in clubs and for film loops; meanwhile, she got ...more
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The son of a Pennsylvania minister, actor Cameron Mitchell first appeared on Broadway in 1934, in the Lunts' modern-dress version of Taming of the Shrew. ...more
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William Smithers +Rating: N/A
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Kenneth Mars +Rating: N/A
Over-the-top comic actor Kenneth Mars made an unbearably funny screen debut as the ex-Nazi playwright responsible for the smash miss "Springtime for Hitler" ...more
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Ernie Orsatti performed stunts and played supporting roles in films of the '70s, '80s, and '90s. ~ Sandra Brennan ...more
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Sari Price +Rating: N/A
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American actor and dancer Justin Smith played character roles in several films of the '60s. A native of Syracuse, NY, he attended college and served in ...more
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Character actor, onscreen from the early '70s. ~ All Movie Guide ...more
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Deb Newman +Rating: N/A
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Thaao Penghlis +Rating: N/A
A native of Sydney, Australia, with a Greek heritage unmistakable from his "exotic" look, actor Thaao Penghlis claims one of the most familiar countenances ...more
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Michael Stearns +Rating: N/A
Maggie Wellman +Rating: N/A
- Kate Parkins (1 episodes)
Jud Taylor +Rating: N/AActor Jud Taylor -- probably best remembered for his role as Steve McQueen's American prisoner-of-war friend in The Great Escape -- turned to directing ...more
David Karp +Rating: N/A
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Coney Island's Luna Park will be kicking off its 2015 season this Sunday, and kids and families are invited to... [more]
Join the Jewish Museum for their annual Passover bash, featuring art, music, and dancing! Rock out to jams from the... [more]
Crockett Johnson's classic children's book, Harold and the Purple Crayon, will come to life during the Enchantment Theatre Company's stage production... [more]
Test your coordination and develop your skills with free juggling lessons! Equipment is provided. 34thstreet.org... [more]
School-age children are invited to put their thinking caps on and participate in a kid-friendly game of Family Feud hosted... [more]
Herald the coming of spring at Macy's annual Flower Show, this year themed "Art in Bloom." Don't miss the ornate arrangements... [more]
It's not spring recess just yet, but if you are looking for something fun to do with the kids, we've... [more]
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The Bloomingdale Library is hosting Fly Girls: A History of Women Aviators, to celebrate various famous female pilots on the... [more]
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I am trying to fix a bug in an existing application, and my MVC ViewBag skills are limited. First off, I don't have the time to refactor and change the code from a ViewBag to a ViewModel, although that would be my preferred approach.
I want to populate a DropDownList from an object in the ViewBag. The code is here:
if(Model != null && Model.WarehouseId != null && !Model.WarehouseId.Equals(String.Empty))
@Html.DropDownListFor(m => m.WarehouseId, (IEnumerable<SelectListItem>)ViewBag.WarehouseCodes)
 //<---
@Html.DropDownListFor(m => m.WarehouseId, (IEnumerable<SelectListItem>)ViewBag.WarehouseCodes, "")

In the case that the WarehouseID is not String.Empty, I ONLY want to load that value into the DropDownList. I'm open to a C# or jQuery answer to this question.
Thanks in advance for any help offered!


text:
Gang Gary Zhao
Princeton Junction, NJ
Basic information on Gang Gary Zhao, Princeton Junction NJ. Find Gang Gary Zhao's age, gender, possible aliases, relationship status and professional status.
Also Known As
Gang Gary Zhao
Gang Gary Zhao is in his 50's
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Princeton Junction, NJ
Palisades Park, NJ
New Haven, CT
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Gang Gary Zhao
Zodiac SignVirgo
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Gang Gary Zhao Has Lived in 6 States
New Jersey Address for Gang Gary Zhao
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Princeton Junction NJ
Princeton Junction NJ
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(609) ***-**** - Barnegat, NJ
(201) ***-**** - Bayonne, NJ
(215) ***-**** - East Greenville, PA
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No. 11 Buckeyes Smother Erskine with 18 Blocks in Four-Set Victory
Ohio State improves to 17-6 on the season
Ohio State Blows by Saint Francis in Three Sets
Buckeyes improve to 16-5 on the season
No. 11 Ohio State Takes Down No. 2 Lewis in Five-Set Thriller
Senior Michael Henchy stars in Buckeye upset bid
OSU Closes Out Extended Home Stand with 3-1 Win Over Saint Francis
The Buckeyes dropped in 14 aces on SFU
Three Matches Out West for #14 Buckeyes
Ohio State travels to California and Hawaii
USA Volleyball: Represented the United States as a member of the Team USA squad that competed at the 2013 FIVB Men's U-21 World Championship in Turkey ... member of gold-medal-winning Team USA at the 2012 Junior Continental Championships.
2014 (Freshman Season): Placed on the AVCA All-America Second Team, the only freshman to earn All-American honors ... recognized by the AVCA as the Newcomer of the Year as well ... a First Team All-MIVA selection ... MIVA Freshman of the Year ... Off the Block/Springback, Inc. Freshman All-American ... paced the MIVA and ranked third nationally with a .446 attack percentage, the 14th-best mark in school history ... racked up 24 solo blocks to rank second in the MIVA for 2014 and top-10 all-time at Ohio State ... his .90 blocks/set (7th), 2.56 kills/set (16th) and 3.10 points/set (16th) all slotted in the MIVA top-20 ... totaled 93 blocks, 264 kills, and 28 digs while starting all 27 matches and playing in every set ... named the MIVA Defensive Player of the Week (2/11) after stuffing 11 blocks (4s, 7a) in eight sets against Penn State (2/5) and Saint Francis (2/9) ... posted double-digit kills in 13 contests, including 10 or more put-aways six times in a seven-match midseason stretch (2/5-3/5) ... a MIVA Academic All-Conference, Academic All-Big Ten and Ohio State Scholar-Athlete honoree.
2013 (Redshirt Season): Did not play ... Ohio State Scholar-Athlete ... MIVA Academic All-Conference.
Prior to Ohio State: Played for coach Michael Boehle at Loyola High School ... led team to state title in 2012 ... named a 2012 AVCA First Team All-American ... 2012 Mission Leage first team and CIF first team ... finished senior season with 299 kills, 89 blocks and a .600 attack percentage ... also played for the Manhattan Beach Surf Volleyball Club coached by John Beckwith ... 2011 USAV Junior National Championship silver medalist.
Personal: Son of Loring Guessous and Amal Guessous ... has an older sister, Kenza ... majoring in physics.


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Grey 'Flex Experience' running trainers
Item No.2830108413
Nike Flex experience run has been stripped back to enhance flexibility. The upper consists of a simple pattern with reduced layering while the articulated phylite midsole provides a lightweight ride with great transition.
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Latest Frog Stories
Three long-lost species of frogs and lizards thought extinct have been re-discovered by scientists who are on a global hunt for "lost" amphibians.
Ever hear of the old tale, if you kiss a frog he will turn into a prince? This old tale may turn into a truthful reality.
Scientists today reported that frog skin contains natural substances that could be the basis for a powerful new genre of antibiotics.
Scientists have discovered one of the world's tiniest frogs the size of a pea in the forests of Borneo.
Conservationists are scouring the world for frog species that are thought to be extinct, but may just be hanging on.
The evolution of a group of muscled frogs scattered throughout Asia is telling geologists about the sequence of events that led to the rise of the Himalayas and the Tibetan plateau starting more than 55 million years ago.
Genetic analysis of 24 spiny frogs supports minority theory of India's collision with Asia.
Scientists track amphibian populations because these animals are sensitive to changes in their environment and can serve as "canaries in the coal mine†to give researchers early warnings about pollution or other ecological problems.
Researchers found that frogs became proficient at jumping before they perfected landing.
Incidence of a lethal infectious disease moves at a rate of 30 kilometers per year.
Latest Frog Reference Libraries
The Wood Frog (Rana sylvatica) has a broad distribution over North America, stretching from the southern Appalachians to the boreal forest with several notable disjunct populations including lowland eastern North Carolina. This frog has garnered attention by biologist over the last century due to its freeze tolerance, relatively great degree of terrestrialism, interesting habitat associations, and relatively long-range movements. The wood frog is the state amphibian of New York. Similar to...
The Common Frog (Rana temporaria), known also as the European Common Frog or the European Common Brown Frog, is located throughout much of Europe as far north as well north of the Arctic Circle in Scandinavia and as far east as the Urals, except for the majority of Iberia, southern Italy, and the southern Balkans. The farthest west it can be found is Ireland, where it has long been considered erroneously to be an entirely introduced species. These frogs measure about 2.4 to 3.5 inches and...
The Mountain Yellow-Legged Frog (Rana muscosa) is a true frog native to California. They can be found in mountain creeks and lakes, meadow streams, isolated pools, and lake borders. They are usually found near steep-gradient streams of a chaparral belt or other water sources around 1,200 to 7,750 feet above sea level. The Southern Mountain Yellow-legged Frog is endangered and the Sierra Mountain Yellow-legged Frog is threatened. This is a small frog, measuring about 5 to 7.5 centimeters....
The Columbia Spotted Frog (Rana luteiventris) is a North American species of frog. It's green to brown in coloration with spots on the dorsal surface. The belly and the upper lip are white. Individuals can be distinguished from other Rana species by their shorter back legs, upturned eyes, and narrow snout. Since they spend the majority of their time within the water, they also have more webbing in their hind feet than similar species. Although they are not threatened, the animal has been...
The Japanese Brown Frog (Rana japonica) is a species of frog belonging to the Ranidae family. It is native to Japan. Its natural habitats include temperate grasslands, rivers, swamps, irrigated land, and seasonally flooded agricultural land. Some defining characteristics include a slender and reddish brown body with a long and narrow head. The average snout to vent length is 48 millimeters for males. The females are normally much larger than the males, with lengths of about 54 millimeters....
- The governor of a province or people.


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Water Issue with Outdoor Hydroponics
Hey guys.
I'm a little noob to hydroponics, but have done tons of research did fairly well with my first outdoor system. I'm using a dutch bucket system, and seems to be working good. However, I'm having a water problem. Its been so hot here I can't keep enough water in the tank. I have to fill it up almost everyday. I don't have any leaks in the plant buckets or the piping. Any advise or tricks on keeping the water/nutrients in the tank longer during very hot temps?
I'm not exactly sure what kind of system a dutch bucket system is, but make sure there are no openings in the reservoir (other than input/ ouput lines) to limit evaporation.
The other culprit is transpiration. If it's really hot and you have a lot of plants, they'll move a lot of water through them to cool off. As Ethno pionted out, cooling the water will help (cooler water cools more while moving less of it)but you may just have too small a reservoir for the number of plants being grown.


text:
TOPIC: Due Process and Breed Discriminatory Laws
SPEAKER: Elise "Ledy" VanKavage, Esq., Senior Legislative Attorney, Best Friends Animal Society.Ledy is the National Manager of Best Friends' Pit Bull Terrier Initiative. She worked for the ASPCA for nine years as Sr. Director of Legislation and Legal Training. She has spearheaded the passage of over 30 humane state bills. Ledy has served as Chair for the American Bar Association's Tort Trial & Insurance Practice Section's Animal Law Committee and serves on the ISBA's Animal Law Committee. She is a co-author of a chapter on dangerous dog ordinances in the American Bar Association Book, Dangerous Dog Laws published in 2009.
This program may qualify for up to one hour of MCLE credit. There is no cost for this meeting, but you must pre-register to receive lunch and program handouts. To register click the link above or call Leslie at 630-653-7779 or email firstname.lastname@example.com
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3930 E Chandler St Carsonville, MI 48419
1105 Greening Rd Carsonville, MI 48419
4052 E Orchard St Carsonville, MI 48419
217 S Main St Carsonville, MI 48419
Get detailed sex offender records, and other important information
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Our database shows there are 10 registered Sex Offenders in Carsonville, MI, a ratio of 173.91 offenders per 10,000 residents. This is higher than the national average of 14.29 offenders per 10,000 residents. Records indicate there are 0 incarcerated sex offenders in Michigan, as well as 10,948 offenders whose location is unknown in Michigan due to the offenders being transient or their address being unmappable.
*No representation is made that the person listed here is currently on the state's offenders registry. All names presented here were gathered at a past date. Some persons listed might no longer be registered offenders and others might have been added. Some addresses or other data might no longer be current. Owners of Homefacts.com assume no responsibility (and expressly disclaim responsibility) for updating this site to keep information current or to ensure the accuracy or completeness of any posted information. Accordingly, you should confirm the accuracy and completeness of all posted information before making any decision related to any data presented on this site.


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Thursday morning an unidentified man allegedly ran on foot onto Interstate 30 hitting the back of a FedEx truck.
The man's name and injuries are unknown at the current time, but he was taken by MedFlight to Baptist Health Medical Center as a precaution, said Benton Fire Battalion Chief Greg Ford.
Earl Leonard Wagner, 96, of Benton, formerly of Hope, died Sunday, Aug. 10, 2014, at Saline Memorial Hospice House.
Earl was born May 26, 1918, in Lafayette, Ind., to the late Edgar and Grace Wagner.
Earl was a Master Electrician, a Navy veteran of World War II, past president of Golden K's in Hope and a past board member of the Hope HUD Board. He was also an active member of the Hempstead County Republican Party and a member of Hope First United Methodist Church.
Lena Wells Vaughn, 91, of Benton went to be with the Lord on Aug. 8, 2014. She was born in Alexander to Leslie and Wreathy McClain on Aug. 15, 1922.
Lena was a member of Holland Chapel Baptist Church in Benton. She loved to cook and prepared many wonderful meals for her family and friends. During the 1950s she was employed by the Benton School District as a cook at Benton High School and volunteered countless hours at Saline Memorial Hospital.


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53 search results for Kyle MacLachlan
Kyle MacLachlan hints he'll return to 'Twin Peaks'
Type: Post | Date: Monday, Oct 6, 2014Bravo denies paying $325,000 to interview the Giudices
Damn good coffee! Kyle MacLachlan joins 'Twin Peaks' revival on Showtime
Type: Post | Date: Monday, Jan 12, 2015Lynch and Frost 'have been very specific about promising closure,' says Showtime boss
'Twin Peaks' is back! 12 reasons why Dale Cooper is still our dream man
Type: Article | Date: Monday, Jan 12, 2015Man or woman, gay or straight - Agent Cooper's got the goods
Twin Peaks: The Entire Mystery [Blu-ray]
Type: Event | Date: Tuesday, Jul 29, 2014A comprehensive collection with every episode from the complete television series
First Look: Lucy Lawless in Marvel's 'Agents of S.H.I.E.L.D.'
Type: Article | Date: Tuesday, Aug 26, 2014'Xena' and 'Battlestar Galactica' vet will play Agent Isabelle Hartley in season 2
Type: Event | Date: Sunday, Mar 16, 2014The series settles into its regular time period tonight.
Type: Event | Date: Monday, Mar 10, 2014The new series gets a special Monday premiere.
'Twin Peaks' to return on Showtime in 2016
Type: Post | Date: Monday, Oct 6, 2014The strangest network drama of them all being revived by creators David Lynch & Mark Frost
'Twin Peaks' Fanatics: Massive 10-Disc Blu-Ray Set Will Make All Your Dreams Come True
Type: Article | Date: Thursday, May 15, 2014Collection to include 90 minutes of never-before-seen 'Fire Walk With Me' footage
Made in Jersey
Type: Event | Date: Friday, Sep 28, 2012A woman proves that it doesn't take a big league education to make it at a big league law firm.


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Loss of heterozygosity for chromosome 18q and microsatellite instability are highly consistent across the region of the DCC and SMAD4 genes in colorectal carcinomas and adenomas.
Loss of beterozygosity (LOH) of chromosome 18q is clearly associated with colorectal carcinoma. The gene DCC (Deleted in Colorectal Cancer) is a putative tumor suppressor gene within the 18q21.2 region, but the importance of D CC bias been questioned. A nearby gene called SMAD4 bias been suggested as the critical tumor suppressor gene in this region. We evaluated a series of 110 colorectal carcinomas and adenomas for LOH of the DCC and SMAD4 genes to clarify the involvement of this DNA segment of chromosome 18q in colorectal carcinogenesis. We utilized 2 markers for eacb gene for all lesions and 5 additional markers for 23 lesions with inconsistent results, using standard PCR techniques. The benign and malignant portions of 50 in situ carcinomas were studied independently. Similar molecular results for LOH of DCC and SMAD4 were found for 122 (79.7%) of 153 informative samples. Our results further show that the development of microsatellite instability within the q21-22 region of chromosome 18 clearly occurs prior to the histological change from adenoma to carcinoma, while LOH of this region of 18q is a late event in the neoplastic process. The physical proximity of these 2 genes will usually, but not invariably, result in similar LOH findings.
KEYWORDS: loss of beterozygosity, chromosome 18% DCC gene, SMAD4 gene, colorectal cancer
Colorectal carcinoma is believed to develop through the accumulation of multiple mutations, either germ line and/or somatic, occurring in oncogenes, tumor suppressor genes, and DNA repair genes. Collectively, the genetic and epigenetic events endow the affected cells with self-sufficiency for growth. (1) Allelic loss, or loss of beterozygosity (LOH), involving several different chromosomal regions bias been associated with colorectal carcinoma. One region shown repeatedly to experience LOH is 18q. (2) A putative tumor suppressor gene was identified within the 18g21.2 region and is referred to as D CC (Deleted in Colorectal Cancer). (3)
However, much of the reported data on loss and inactivation of the DCC gene is circumstantial and fails to provide conclusive evidence that the D CC gene functions as a tumor suppressor gene, rather than merely being an epiphenomenon. (4) These authors point out there is no evidence that germ line mutations of the DCC gene play a role in heritable cancer, unlike true tumor suppressor genes. Further, very few somatic mutations in the DCC gene have been reported in colorectal carcinoma tissue. (4) With other tumor suppressor genes, somatic mutations are frequently responsible for the inactivation of the remaining allele, following LOH of one of the gene pair. Another gene, referred to as SMAD4, also found in the region affected by 18q LOH, bas been suggested as the critical putative tumor suppressor gene in colorectal carcinomas. (4) The SMAD4 gene encodes a protein involved with transforming growth factor beta (TGF-beta) signaling. Transforming growth factor beta normally bas inhibitory effects on colonic epithelial cells, and loss of TGF-beta function, as a result of loss of SMAD4 function could, therefore, be important in colorectal carcinoma development. (5,6)
We evaluated a series of colorectal carcinomas and adenomas for LOH of the D CC and SMAD4 genes to better understand the involvement of this DNA segment of chromosome 18q in colorectal carcinogenesis. Two markers frequently used to assess for LOH for each gene were initially assessed. When LOH results were discrepant with this first set, additional markers were then utilized. A series of in situ carcinomas (ISCs) was also studied by separately assaying the benign adenomatous portion as well as the malignant portion to compare the frequency of LOH of this chromosomal region in the 2 stages of the evolving neoplasm. Each area of the in situ neoplasms could be assessed independently, since our focus is the comparison of markers to each other. Finally, DNA from a series of samples was sequenced to assess the major hot spot for mutations within the SMAD4 gene.
MATERIALS AND METHODS LOH Determinations
Fifty percent of 220 tissue DNA samples of neoplasms from 2 prior molecular pathology studies were randomly picked for this analysis. (7,8) Paraffin blocks were available from storage. No protected health information was sought for any patient, thus the protocol was approved by the hospital Institutional Review Board with a Health Insurance Portability and Accountability Act (HIPAA) waiver.
Loss of beterozygosity of the SMAD4 gene region was initially determined by polymerase chain reaction (PCR) amplification of the microsatellite CA repeats D18S474 and D18S1110. Loss of beterozygosity of the D CC gene region was determined by amplification of the CA repeat markers within the D1 8S58 and D18S61 loci. Additional markers utilized included D18S45, D18S838, D18S1099, D18S1407, and D18S70. Primer sets were abstracted from information listed on the National Center for Biotecbnology Information (NCBI) Web site (www.ncbi.nlm.nib.gov) or the Ensembl Web site (www.ensembl.org). The primer sets used are showed in Table 1, and the relative locations of all markers are shown in Figure 1. Labeled primers were obtained from the Applied Biosystems Custom Oligo Synthesis Service (email@example.com). In the primer sets, 1 primer contained a 5' fluorescent label while the other primer contained a 5'-GTGTCTT tail.
Polymerase chain reactions were carried out in 30 [micro]L volumes using Applied Biosystems reagents (Roche Molecular Systems, Inc., Branchburg, NJ). Four picomoles of each primer and a 1.5-mM Mg[Cl.sub.2] concentration were used in the reactions. Reactions were run on a PE 9700 thermocycler (Applied Biosystems, Foster City, CA) under the following conditions: b minutes denaturation at 94[degrees]C, followed by 35 cycles of a 30-second denaturation at 94[degrees]C 25-second annealing at 55[degrees]C, and a 50-second elongation at 72[degrees]C with a final 30-minute extension at 72[degrees]C. Polymerase chain reactions products were analyzed on an ABI 3130 Genetic Analyzer with GeneMapper software (Applied Biosystems, Foster City, CA). For all LOH studies, neoplastic tissue was evaluated simultaneously with normal colonic mucosal tissue from the same patient. The ratio of the height of the allele band intensities of the neoplastic tissue was divided by the corresponding ratio for the normal tissue, and LOH was defined as a resultant ratio of [less than or equal to] 0.5. (9) A representative plot is shown in Figure 2.
Microssatellite Instability (MSI) Testing
All lesions bad previously been assayed for APC gene LOH using marker D5S34b, part of the Betbesda panel for MSI analysis. Any sample showing MSI with the four 18q markers was additionally assayed with the marker BAT2b. Microsatellite instability by the 3 markers was considered MSI-bigb.
SMAD4 Gene Sequencing
Exon 8 of the SMAD4 gene was sequenced to detect somatic mutations within this region. Primers were designed from sequence information listed at the NCBI Web site under accession AF045438. Primers were ordered through Sigma Genosys. (www.sigmagenosys.com). The primer set is 5'- GAT GTT CTT TCC CAT TTA TTT CC-3' (sense) and 5'- TAA AGT AAC TAT CTG ACT ATA CAA TC-3' (antisense), and it generates a 243-base pair PCR product spanning codons 319 to 379. Hot-start PCR reactions were run on a PE 9700 themocycler (Applied Biosystems, Foster City, CA) using 75 picomoles of each primer and a 1.75-mM Mg[Cl.sub.2] concentration. The reaction tubes were initially denatured for b minutes at 94[degrees]C, cooled to 90[degrees]C and paused to add Taq polymerase, and then heated for an additional 1 minute at 94[degrees]C. This was followed by 35 cycles of a 30-second denaturation at 94[degrees]C, 25-second annealing at 50[degrees]C, and a 50-second elongation at 72[degrees]C, with a final 5-minute extension at 72[degrees]C. Post PCR product was purified and sequenced, and then separated on a 5 % Long Ranger acrylamide gel (Cambrex, Rockland, ME).
The 110 lesions were removed from 88 individuals, 47 females and 41 males. The average age at the time of removal was 71.2 years. Fifty of the 110 lesions were ISCs that could be easily separated into benign and malignant parts, yielding an additional 50 samples for analysis. The lesions studied were: carcinomas, 42; ISCs, 50,(44 bad residual villous adenoma and 6 bad residual tubular adenoma); vinous and tubulovillous adenomas, 9; tubular adenomas, 8; and byperplastic polyp, 1. Lesions were from all segments of the colon: cecum, 22; ascending, 28; transverse, 13; descending, 5; sigmoid, 24; and rectum, 18. Seven carcinomas from 7 different patients revealed MSI by all 4 initial markers. These lesions also demonstrated MSI with the markers D5S346 and BAT26, indicating MSI-high. No other lesions demonstrated MSI-high. Of these 7 patients, 6 were female and 1 was male. Their average age at the time of diagnosis was 78.1 years. Six of the 7 MSI-positive lesions were from the right colon and 1 was from the sigmoid. The prevalence of homozygosity for the 4 primary markers used was as follows: 25 of 78 (32%) individuals were homozygous for D1 8S58 and 12 of 78 (15%) were homozygous for 018S61; 16 of 79 (20.3%) individuals were homozygous for D18S474 and 5 of 79 (6.3%) for D18S1110.
Comparison of 4 Initial Markers
The combined results of the 2 D CC markers (D18S58 and D18S61) were compared to the combined results for the 2 SMAD4 markers (D18S474 and D18S1110). The 160 separate samples yielded 7 samples from patients homozygous for 3 of the 4 markers. Five of these samples yielded consistent results between the informative, fourth primary marker, and 3 additional markers (4 lesions showed no LOH and 1 lesion showed LOH), but 2 samples revealed discrepant results and were then studied further with the complete expanded panel.
Results for the remaining 153 samples were considered consistent if results from all 4 markers demonstrated the same result, or if at least one of each pair of markers demonstrated the same result, with the other marker either homozygous or not studied. There were 122 (79.7%) samples with the same results: 66 (54.1%) normal, 44 (36.1%) with LOH, and 12 (9.8%) samples with MSI. There were 31 (20.3%) samples with discrepant results, and DNA was available for study with the expanded panel for 21 of these samples.
Thus, 23 samples were further studied using 5 additional markers for a total of 9 markers. The results could be separated into 4 groups: A. Eight samples gave consistent results save for 1 marker; 5 were predominately LOH and 3 were predominately normal. B. Four samples, representing the 2 parts of 2 in situ lesions, revealed a mix of MSI and normal, but with MSI seen across the region. These 2 in situ neoplasms did not demonstrate MSI with markers D5S346 or BAT26. C. Five samples revealed little or no LOH with centromeric markers and LOH with telomeric markers. D. Results for b samples were more variable. (Groups C & D are illustrated in Figure 3.)
Comparison of the 2 Histologically Different Areas of in situ Lesions
Fifty ISCs were studied with the 4 markers D18S58, D18S61, D18S474, and D18S1110. Five ISCs were informative for just 1 marker. A total of 45 ISCs were informative for both the benign and malignant portions for at least 2 of the 4 markers. For 32 of these ISCs (71%), the marker results were consistent: adenoma/cancer bothnormal, 12; both LOH, 2; botb MSI, 5; normal/LOH, 12, and LOH/normal, 1. Of the 13 ISCs with inconsistent results among the four markers, 10 varied by just 1 marker (Table 2).
Sequencing of SMAD4 Gene
Twenty four lesions showing LOH with both D18S474 and D18S1110, or for one marker with the other marker homozygous, were sequenced looking for possible mutations in exon 8, codons 319 to 379. Twenty three of the 24 lesions were carcinomas, and 1 lesion was a tubular adenoma. All 24 lesions revealed no abnormalities in the exon 8 region by sequencing.
Multiple genetic alterations are involved in the initiation and progression of carcinogenesis. These affect both proto-oncogenes and tumor suppressor genes. Two "bits" are needed for inactivation of tumor suppressor genes; the first is often a point mutation, either germ line or somatic. The second "bit" is the elimination of the wild-type allele through nondisjunction, deletion, recombination, and/or chromosome loss and duplication This results in the primary mutation. becoming homozygous or hemizygous, thus the term "loss of heterozygosity." (10)
Loss of beterozygosity of chromosome 18q is common in primary colorectal carcinoma, but it is infrequent in small adenomas, leading to the conclusion that 18q LOH may contribute more to progression rather than initiation of colorectal carcinoma. More than 90% of primary colorectal carcinomas with LOH of chromosome 18q have allelic loss of the region that includes the DCC gene. (11) The DCC gene is quite large, with 29 or more exons, and it spans a large genomic region of about 1.2 million base pairs. (12) The DCC gene encodes several different protein products as a result of alternative splicing. All known isoforms appear to be transmembrane glycoproteins. The extracellular domain is similar to that found in the neural cell adhesion molecule protein family. (4) The expression of DCC protein, as determined by immunohistochemistry, bas been reported as a strong positive predictive factor for survival in stage 11 and III colorectal carcinomas. (13) However, in a mouse model, inactivation of the murine DCC gene did not affect growth, differentiation, morphogenesis, or tumorigenesis in the mouse intestine. (14)
The SMAD4 gene was first identified as a tumor suppressor gene of pancreatic cancer in 1996 and was designated as DPC4 (deleted in pancreatic carcinoma, locus 4) Y The human DPC4 gene contains 11 exoras with a predicted 155 amino acid coding sequence, or just 466 base pairs. (15) The DPC4 protein sequence bas similarities to the Drosophila melanogster Mad (mothers against dpp) protein, and to the Caenorhabditis elegans Mad homologs sma-2, sma-3 and sma-4. (16) The DPC4 gene is the human homolog of sma-4 and is referred to as SMAD4.
The SMAD4 gene, located at 18g21.1, is closer to the centromere of chromosome 18 than is the DCC gene. Germ line mutations in the SMAD4 gene have been shown to be associated with juvenile polyposis, an autosomal dominant syndrome predisposing to hamartomatous polyps and colorectal carcinoma. (17) Animal studies have shown that SMAD4 gene inactivation is involved in the malignant transformation of gastrointestinal adenomas." Loss of SMAD4 gene expression bas been shown to be highly correlated with the loss of expression of E-cadherin, which is important in the control of cell adhesion. (19) These relationships indirectly support SMAD4, rather than DCC, as the critical gene in the 18q region.
We found the marker D18Sb1 to be more informative than D18S58, as it was twice as likely to be heterozygous. D18S1110 was a more informative marker than D18S474, as it was 3 times more likely to be heterozygous. Results among the 4 primary markers were consistent in 80% of samples.
The results obtained by evaluating 23 samples with 5 additional markers indicated several interesting points. First, homozygosity may not be consistent across this region of chromosome 18. As indicated in Figure 3, regions of homozygosity may be interspersed with heterozygous regions. Second, MSI may not be appreciated with all markers. We believe this results from technical considerations, including the sensitivity of the various markers for detecting extra peaks. Third, for a minority of samples, one marker may fail to show LOH, while all other markers for the region suggest LOH. We found the markers D18S110 and D18Sb1 to be least reliable in this regard, probably for technical reasons. For example, some markers provide a better separation of the 2 alleles than others, thereby facilitating the interpretation of LOH. Fourth, with 5 of our samples, the ratios for the informative centromeric markers were around 1.0, while the telomeric markers gave ratios well below 0.5. This would suggest that in a small minority of neoplasms, LOH might be present in the more distal area of this chromosomal region but not in the more proximal, or centromeric, area.
Sequencing the SMAD4 gene bas been reported for a total of 353 carcinomas, with mutations detected in 49 (13.9%) (20-26) The mutation was reported to be in exon 8, between codons 319 and 379, for 17 of the 49 (34.7%) carcinomas with a documented mutation, but in exon 8 for just 4.8% of all carcinomas (17 of 353). We found no sequencing abnormalities in exon 8 for the 24 lesions studied. However, based upon the 4.8% rate for mutations in exon 8, we would have anticipated finding only 1 lesion with an exon 8 mutation (0.048 x 24).
The development of MSI for the q21-22 region of chromosome 18 clearly occurs prior to the histological change from adenoma to carcinoma, as all 7 in situ lesions demonstrating MSI in the carcinomatous portion also showed MSI in the adenomatous portion. This was demonstrated equally well with all markers used. Furthermore, when MSI occurs, it is clearly present across the endure region studied.
There are few literature reports of SMAD4 LOH or mutations in adenomas. Miyaki et all (23) reported no SMAD4 mutations detected in 40 adenomas but LOH was demonstrated for 1 adenoma. Maitra and colleagues (27) reported that 19 adenomas evaluated by immunohistochemistry for SMAD4 protein were all positive, suggesting normal expression of the gene. We studied 17 independent adenomas and just 1, a sigmoid tubulovillous adenoma, showed LOH for 2 of the initial 4 markers. For several of the in situ lesions with LOH in the carcinomatous portion, the adenomatous portion also demonstrated LOH with each marker used. However, for the majority of ISCs where the carcinomatous portion demonstrated LOH, the residual adenomatous area of the lesion did not. This supports the concept that LOH of this region of chromosome 18 is frequently a late event in the neoplastic process. Precisely when these molecular changes occur may not be identical in all cases, but may reflect different genetic predispositions and different mutagenic influences to which patients are exposed. Furthermore, there were 4 different in situ lesions with LOH demonstrated in the adenomatous portion but not in the carcinomatous portion, for 1 or more marker. This supports the concept that initial molecular genetic changes in an adenoma are not always carried along into the developing carcinomatous lesion, a process that bas been suggested by others. (28)
In summary, similar molecular results for markers in the region of chromosome 18 containing the genes D CC and SMAD4 were found for 122 (79.7%) of 153 of our informative samples. This indicates that the physical proximity of these 2 genes will usually, but not invariably, result in their sharing a similar molecular fate. Our data do not permit a conclusion regarding whether DCC or SMAD4 is the more biologically relevant gene involved in the neoplastic process, to the exclusion of the other. It is possible that one of the 2 genes may be more critical than the other for certain lesions at particular stages of neoplasm development. Our data show that the development of MSI occurs prior to the histological change from adenoma to carcinoma, while LOH of this region is frequently a late event in the neoplastic process.
The authors wish to thank Dr. Errol Berman for review of histological slides. Financial support was from the H. Nussbaum Foundation of Saint Barnabas Medical Center and Cancer Research, UK.
All authors report they have no conflict of interest with respect to this study.
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Peter Zauber, MD (1) Marlene Sabbath-Solitare, PhD (2) Stephen P Marotta, PhD (2) Timothy Bishop, PhD (3)
(1) Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA
(2)Department of Pathology, Saint Ba mabas Medical Center, Livingston, New Jersey, USA
(3) Genetic Epidemiology Division, St. James's University Hospital, Leeds, England
Table l. Microsatellite Markers: Location and the Primers. Forward primer listed first, reverse Marker Locus primer second for each marker D18S45 18q11.1~11.2 5'- TTC TGG GTC ATG CAC ACA AT 5'- GTA GTT ATT TTAAAG CCC GCC C D18S1110 18q21.1 5'- GCA CGC AAT TCA AAA GCT AG 5'- AAA GGC CTA GCA CCA CCT TAG D18S474 18q21.1 5'- AGG CTG TCC TGT GCA CTA TG 5'- TGT CAG AAG GCA TTT GTG ATG D18S838 18q21.1 5'- AGC TTT ATC TTG AAG GTT GCA C 5'- GTT TAC CCG GCC ATG AG D18S1099 18q21.1 5'- CTA AAA GCG TCA CTC ACA CAG 5'- TTA TAG CAA CAC AAG AAC AGC C D18S1407 18q21.3 5'- TTC CCT TCA TTT CAC TGG GA 5'- CTA GAT GGA TGT GAC TTG GC D18S61 18q22.2 5'- ATT TCT AAG AGG ACT CCC AAA CT 5'- ATA TTT TGA AAC TCA GGA GCA T D18S58 18q22.3 5'- GCT CCC GGC TGG TTT T 5'- GCA GGA AAT CGC AGG AAC TT D18S70 18q23.0 5'- AAG GCT GAN CTC TAC CG 5'- GGA ATG TCA AGA AGT ACC TAC CAT A Table 2. Results of Assays for LOH at 4 Markers for 50 in situ Colorectal Carcinomas. Marker: Adenomatous Portion/Carcinomatous Portion D18S58 D18S61 D18S474 D18S1110 MSI/MSI 5 5 6 7 LOH/LOH 6 5 3 7 Normal/LOH 7 15 12 15 LOH/Normal 0 3 2 2 Normal/MSI 0 1 0 0 Normal/Normal 7 15 16 12 Homozygous 15 5 11 4 Not assayed 10 1 0 3 LOH = loss of heterozygosity; MSI = microsatellite instability.
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by Ray Foley
January 28, 2014
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This latest edition of Bartending For Dummies features over 1,000 drink recipes in an A-Z format with clear, easy-to-follow instructions. This 5th Edition also provides over 40 new cocktails ideas for those who want to know how to serve cocktails professionally, for themselves, or for their guests.
If you''re interested in crafting traditional or modern cocktails, Bartending For Dummies has you covered.
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Published: January 28, 2014
Publisher: Wiley
Language: English
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by Ray Foley
Introduction 1
Part I: Getting Started with Bartending 5
Chapter 1: Just for Openers: The Right Tools and Glasses 7
Chapter 3: Setting Up Your Home Bar 23
Chapter 4: Charts and Measures 33
Part II: Distilling the High Points of Various Spirits 41
Chapter 5: American and Canadian Whisk(e)y 43
Chapter 6: Aperitifs, Cordials, and Liqueurs 53
Chapter 7: Beer 63
Chapter 8: Brandy 67
Chapter 9: Cognac and Armagnac 73
Chapter 10: Gin 79
Chapter 11: Irish Whiskey 83
Chapter 12: Rum 87
Chapter 13: Scotch Whisky 93
Chapter 14: Tequila and Mezcal 99
Chapter 15: Vodka 105
Chapter 16: Wine 111
Part III: Cocktail Recipes 119
Chapter 17: Recipes from A to Z 121
Chapter 18: Martini Madness 297
Chapter 19: Drinks for Special Occasions 305
Chapter 20: Breakfast Cocktails 315
Chapter 21: Nonalcoholic Drinks 319
Part IV: The Part of Tens 323
Chapter 22: Ten Toasts to Mark Any Occasion 325
Chapter 23: At Least Ten Cures and Lores 327
Recipes Index 329
Topics Index 361
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At just 8mm thick and packing a directional mic and speaker, the Hot Watch links to iPhones and Android devices to view alerts and take calls hands-free.
Unless you're the most devoted Dyson loyalist, you'll find much better values if you shop around -- including Dyson's own AM05.
In advance of the release of the latest Avengers movie, Hot Toys has been putting out some fine hero replicas, including this stealth-suited Stark.
Running low on something? Put an Amazon Dash Button in your home to instantly order more. Also Google makes a bigger push for Chrome OS in classrooms with new Chromebooks and the Chromebit HDMI stick.
For road warriors, the Sprint Overdrive mobile hot spot offers reliable and fast 4G speeds, provided you live in a coverage area. If not, it does 3G, too; we just wish it had a longer battery life.
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They're hot, they're new, and they're all vying to make you want to upgrade your current cold, old TV of 2014 or earlier. Will they succeed? Read on to find out!
A NASA video shows what an astronaut would experience catching a ride on Orion as it re-enters Earth's atmosphere.
On April 1, Netflix is giving a lot of movies the axe, no joke. Not to worry -- here's what's replacing them.
Each year NASA's Earth Observatory picks enlightening or incredible images of our planet taken from space and has the public vote on them in Tournament: Earth. Here are Crave's favorites.
An Instagram campaign gives salads a glamorous male-model makeover by combining attractive guys and alluring lettuce.


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ur super gay lmao delete ur gay mod ivans gayness
weed ghost
ur super gay lmao delete ur gay mod ivans gayness
1887 is such a piece of **** it's not even funny It shouldn't have even been mentioned.
You won't be able to pull this off.
I hate the voice acting.
when I start up it doesn't ****** work
Post the source files of the models/UV'd textures
Need a mapper?
Do you have a 8 year old computer or something?
I'm willing to help you out on the mod.
1187 was a terrible mod.
There will be blood.
It's custom made by gabe.
Grip could look a little better. everything else is spectacular.
So sexy.
Glad to see some of my perks got in.
I don't like the white metal.
I could test. I'm also a Mapper for Debauchery and Frozen Tundra.
gaylea u have a dull face wow fgt
ur face is dull
Did know one notice all the copying from the original hl2 maps?
tsk tsk tsk...
It won't be on xbox, The mod probably won't even be released.
on some gay map made by some ******
gay avatar
If it's actually constructive, then feel free to post.
Erm... Care to elaborate?
Like you're in any position to call us bad, lol.
Ever hear of WORK IN PROGRESS?
They're VERY wip right now.
I know what you mean. The layout wasn't well thought out.
add a func_smokevolume and it's a revolutionary masterpiece of mapping.
jesus christ, atleast make your own models.
hol y ****
good mod
Looks like a really expensive car, Like most people won't be able to afford it. I suggest adding some less futuristic cars/styling cars.
Who ever is making this mod is a ******* thief.
Why is every mod now a days in goddamn russia?
I hate mods that do this.
Instead of wasting your time making posters, work on the goddamn mod.
It looks fine to me
kewl mango
It's Gm_atomic.


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Free Concert With The Lost Trailers Tonight In Bangor [AUDIO]
I guess sometimes the best things in life are free. Tonight at 7, there will be a free concert with the country band The Lost Trailers, at the Darling's Waterfront Pavilion in Bangor.
I guess sometimes the best things in life are free. Tonight at 7, there will be a free concert with the country band The Lost Trailers, at the Darling's Waterfront Pavilion in Bangor.
Shania Twain will be back in Las Vegas this fall with her show, Shania: Still The One. This October, the superstar will be playing at The Colosseum at Caesars Palace with 22 performances scheduled.
B98.5 presents a 'Contest Couple' to win tickets to see Miranda Lambert, plus we'll send you backstage.
He 'Did It For The Girl'...and now he's doing it for everyone!
Country hitmaker Greg Bates will take the stage at the Union Fair August 23rd at 8pm!
If you want to know ANYTHING about Randy Travis, I'm the girl to ask! I've been in love with him since I was 12.
No joke.
And 'On The Other Hand' has a special place in my heart. Here's why:
This is another band I would love to see! And I've never been to the Fryeburg Fair.
Diamond Rio has incredible harmonies and they sing some of my favorite songs including 'Unbelievable' and 'That's How Your Love Makes Me Feel'-I call it the Cow Song.
And they are coming to the Fryeburg Fair on October 1st!
Want to hear 'Fishin' In The Dark' LIVE and IN PERSON?
You can at the Waterville Opera House on Thursday October 3rd at 8pm!
And tickets are on sale NOW!
The Red Barn in Augusta had it's request denied by the Augusta Planning Board last night by a 5 to 1 vote. The Red Barn was looking for a request to exceed the city's 60-decible noise limit during a weekly summer series of outdoor concerts.
Have you heard his first single "Lucky Sometimes"? Then you know that this up-and-comer has got what it takes to have some staying power!
And he could be performing for you in your very own backyard...
If you win!