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Publications (28)184.41 Total impact
Article: Pancreatic Neuroendocrine Tumors: Accurate Grading With Ki-67 Index on Fine-Needle Aspiration Specimens Using the WHO 2010/ENETS Criteria[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND The natural history of pancreatic neuroendocrine tumors (panNETs) is extremely variable. One of the most controversial problems in diagnosis is the accurate prediction of the clinical behavior of these tumors. PanNETs that behave aggressively with a malignant course may have bland cytologic features, while some tumors with previously described "malignant" features may behave in a benign or indolent fashion. Various classification schemes have been proposed for grading panNETs. The European Neuroendocrine Tumor Society (ENETS) and 2010 World Health Organization (WHO) classification schemes include counting the mitotic index and/or the Ki-67 proliferation index for grading. The current study was undertaken to determine whether tumors sampled by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) can be accurately graded based on the Ki-67 index when compared to surgical samples.METHODS Corresponding EUS-FNA cytology and surgical tissue specimens were obtained for 22 tumors and stained for hematoxylin and eosin (H&E) and the Ki-67 proliferation marker (MIB-1 antibody). Samples were graded by scoring Ki-67 staining indices in accordance with the 2010 ENETS/WHO criteria. The grading scores assigned to the EUS-FNA cytology samples were compared with the scores assigned to the corresponding histological samples.RESULTSThe majority (86%) of EUS-FNA cytology samples and corresponding surgical tissue specimens demonstrated concordant grading based on Ki-67 indices.CONCLUSIONS These results indicate that EUS-FNA cytology samples can be accurately graded based on the WHO Ki-67 labeling scheme. Thus, Ki-67 scoring in EUS-FNA cytology samples is an alternative approach for establishing the grade of panNETs. Accurate grading of panNETs is critical for predicting tumor biology, patient prognosis, and making informed decisions regarding patient management and treatment. Cancer (Cancer Cytopathol) 2014. © 2014 American Cancer Society.Cancer Cytopathology 10/2014; 122(10). DOI:10.1002/cncy.21457 · 4.43 Impact Factor
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ABSTRACT: miRNA levels are altered in pancreatic ductal adenocarcinoma (PDA), the most common and lethal pancreatic malignancy, and intact miRNA processing is essential for lineage specification during pancreatic development. However, the role of miRNA processing in PDA has not been explored. Here we study the role of miRNA biogenesis in PDA development by deleting the miRNA processing enzyme Dicer in a PDA mouse model driven by oncogenic Kras. We find that loss of Dicer accelerates Kras driven acinar dedifferentiation and acinar to ductal metaplasia (ADM), a process that has been shown to precede and promote the specification of PDA precursors. However, unconstrained ADM also displays high levels of apoptosis. Dicer loss does not accelerate development of Kras driven PDA precursors or PDA, but surprisingly, we observe that mouse PDA can develop without Dicer, although at the expense of proliferative capacity. Our data suggest that intact miRNA processing is involved in both constraining pro-tumorigenic changes in pancreatic differentiation as well as maintaining viability during PDA initiation.PLoS ONE 05/2014; 9(5):e95486. DOI:10.1371/journal.pone.0095486 · 3.53 Impact Factor
Article: The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.[Show abstract] [Hide abstract]
ABSTRACT: Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions, including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). However, genetic features resulting in IPMN-associated PDA (IPMN-PDA) versus PanIN-associated PDA (PanIN-PDA) are largely unknown. Here we find that loss of Brg1, a core subunit of SWI/SNF chromatin remodelling complexes, cooperates with oncogenic Kras to form cystic neoplastic lesions that resemble human IPMN and progress to PDA. Although Brg1-null IPMN-PDA develops rapidly, it possesses a distinct transcriptional profile compared with PanIN-PDA driven by mutant Kras and hemizygous p53 deletion. IPMN-PDA also is less lethal, mirroring prognostic trends in PDA patients. In addition, Brg1 deletion inhibits Kras-dependent PanIN development from adult acinar cells, but promotes Kras-driven preneoplastic transformation in adult duct cells. Therefore, this study implicates Brg1 as a determinant of context-dependent Kras-driven pancreatic tumorigenesis and suggests that chromatin remodelling may underlie the development of distinct PDA subsets.Nature Cell Biology 02/2014; DOI:10.1038/ncb2916 · 20.06 Impact Factor
Article: The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.[Show abstract] [Hide abstract]
ABSTRACT: Loss-of-function of alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein leads to a phenotype called alternative lengthening of telomeres (ALT) in some tumors. High-grade astrocytomas comprise a heterogeneous group of central nervous system tumors. We examined a large cohort of adult (91) and pediatric (n=88) high-grade astrocytomas as well as lower grade forms (n=35) for immunohistochemical loss of ATRX protein expression and the presence of ALT using telomere-specific fluorescence in situ hybridization, with further correlation to other known genetic alterations. We found that in pediatric high-grade astrocytomas, 29.6% of tumors were positive for ALT and 24.5% were immunonegative for the ATRX protein, these two alterations being highly associated with one another (P<0.0001). In adult high-grade astrocytomas, 26.4% of tumors were similarly positive for ALT, including 80% of ATRX protein immunonegative cases (P<0.0001). Similar frequencies were found in 11 adult low-grade astrocytomas, whereas all 24 pilocytic astrocytomas were negative for ALT. We did not find any significant correlations between isocitrate dehydrogenase status and either ALT positivity or ATRX protein expression in our adult high-grade astrocytomas. In both cohorts, however, the ALT positive high-grade astrocytomas showed more frequent amplification of the platelet-derived growth factor receptor alpha gene (PDGFRA; 45% and 50%, respectively) than the ALT negative counterparts (18% and 26%; P=0.03 for each). In summary, our data show that the ALT and ATRX protein alterations are common in both pediatric and adult high-grade astrocytomas, often with associated PDGFRA gene amplification.Modern Pathology advance online publication, 14 June 2013; doi:10.1038/modpathol.2013.90.Modern Pathology 06/2013; DOI:10.1038/modpathol.2013.90 · 6.36 Impact Factor
Article: Lymph Node Sampling Rates and Predictors of Nodal Metastasis in Pancreatic Neuroendocrine Tumor Resections The UCSF Experience With 149 Patients[Show abstract] [Hide abstract]
ABSTRACT: The decision to perform pancreas-preserving procedures or standard resections for pancreatic neuroendocrine tumors (PNETs) is often based on the perceived risk of malignancy, including potential nodal involvement. We sought to identify clinicopathological factors that predict nodal disease. This is a retrospective review of pathology database for PNET resections from January 1, 1988, to March 15, 2010. Univariate analysis and multivariate logistic regression were used to identify predictors of nodal metastasis. A total of 149 patients were identified. Enucleations had lower lymph node sampling rates compared to major resections. Excluding enucleations, 23% of patients had no lymph nodes sampled. For patients who did have lymph nodes evaluated, a median of 5 lymph nodes were examined. On multivariate analysis, only distant disease predicted nodal metastasis (odds ratio = 3.80, P = 0.02); tumor size did not (P = 0.48). One third of patients with lymph node metastasis had tumors less than 3 cm. Lymph nodes are not evaluated in many major pancreatic resections for PNET, and preoperative prediction of nodal metastasis is difficult, even when tumor size is considered. Consequently, many patients may be understaged and undergo potentially inadequate resection. Inconsistent lymph node sampling may explain conflicting conclusions in the literature regarding the prognostic value of lymph node involvement in PNET patients.Pancreas 08/2012; 41(6):840-4. DOI:10.1097/MPA.0b013e31823cdaa0 · 3.01 Impact Factor
Article: Development of anaplastic wilms tumor and subsequent relapse in a child with diaphanospondylodysostosis.[Show abstract] [Hide abstract]
ABSTRACT: Diaphanospondylodysostosis (DSD) is a rare skeletal dysplasia syndrome resulting from disordered mesenchymal differentiation. Children with DSD generally die in utero or during the first month of life from severe thoracic insufficiency syndrome. An association of DSD with nephroblastomatosis has been observed, but the natural history of such nephroblastomatosis remains poorly characterized due to the rarity of the underlying condition. We describe a patient with DSD who developed bilateral hyperplastic nephroblastomatosis that ultimately evolved into therapy-resistant anaplastic Wilms tumor (nephroblastoma).Journal of Pediatric Hematology/Oncology 03/2012; 34(7):548-51. DOI:10.1097/MPH.0b013e3182465b58 · 0.96 Impact Factor
Article: Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.[Show abstract] [Hide abstract]
ABSTRACT: An essential regulator of gene transcription, nuclear receptor liver receptor homologue 1 (LRH-1) controls cell differentiation in the developing pancreas and maintains cholesterol homeostasis in adults. Recent genome-wide association studies linked mutations in the LRH-1 gene and its up-stream regulatory regions to development of pancreatic cancer. In this work, we show that LRH-1 transcription is activated up to 30-fold in human pancreatic cancer cells compared to normal pancreatic ductal epithelium. This activation correlates with markedly increased LRH-1 protein expression in human pancreatic ductal adenocarcinomas in vivo. Selective blocking of LRH-1 by receptor specific siRNA significantly inhibits pancreatic cancer cell proliferation in vitro. The inhibition is tracked in part to the attenuation of the receptor's transcriptional targets controlling cell growth, proliferation, and differentiation. Previously, LRH-1 was shown to contribute to formation of intestinal tumors. This study demonstrates the critical involvement of LRH-1 in development and progression of pancreatic cancer, suggesting the LRH-1 receptor as a plausible therapeutic target for treatment of pancreatic ductal adenocarcinomas.Proceedings of the National Academy of Sciences 09/2011; 108(41):16927-31. DOI:10.1073/pnas.1112047108 · 9.81 Impact Factor
Article: Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver[Show abstract] [Hide abstract]
ABSTRACT: Glypican-3 (GPC3) is an oncofetal protein that has been demonstrated to be a useful diagnostic immunomarker for hepatocellular carcinoma and hepatoblastoma. Its expression in mesenchymal tumors of the liver, particularly undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH), has not been investigated. In this study, a total of 24 UESs and 18 MHs were immunohistochemically stained for GPC3 expression. The results showed cytoplasmic staining for GPC3 in 14 (58%) UESs, of which 6 exhibited diffuse immunoreactivity and the remaining 8 showed focal positivity. The patients with GPC3-positive UES tended to be younger (mean 18 years; median 11 years) than those with GPC3-negative tumors (mean 39.4 years; median 27 years), although the difference did not reach statistical significance (P = .06). Eight MHs also exhibited GPC3 immunoreactivity (44%; 4 diffuse and 4 focal). Positive staining in all 8 cases was primarily seen in entrapped nonlesional hepatocytes with a canalicular and cytoplasmic staining pattern. In only 4 cases (22%) was GPC3 immunoreactivity also observed in the mesenchymal component. The patients with positive staining also tended to be younger (mean 2.6 years; median 1.1 years) compared with those with negative staining (mean 16.3 years; median 4.5 years), but the difference was not statistically significant (P = .15). Our data demonstrate that GPC3 is expressed in a subset of UES and MH of the liver. Caution should thus be exercised when evaluating a GPC3-expressing hepatic neoplasm, particularly on a needle biopsy when the differential diagnosis includes poorly differentiated hepatocellular carcinoma or hepatoblastoma.Human pathology 09/2011; 43(5):695-701. DOI:10.1016/j.humpath.2011.06.016 · 2.81 Impact Factor
Article: Morphologic Findings in Progressive Familial Intrahepatic Cholestasis 2 (PFIC2): Correlation With Genetic and Immunohistochemical Studies[Show abstract] [Hide abstract]
ABSTRACT: Progressive familial intrahepatic cholestasis, type 2 (PFIC2), characterized by cholestasis in infancy that may progress to cirrhosis, is caused by mutation in ABCB11, which encodes bile salt export pump (BSEP). We correlated histopathologic, immunohistochemical, and ultrastructural features in PFIC2 with specific mutations and clinical course. Twelve patients with clinical PFIC2 and ABCB11 mutations were identified, and 22 liver biopsy and explant specimens were assessed. All had hepatocellular cholestasis; most had canalicular bile plugs. At least 1 specimen from every patient had centrizonal/sinusoidal fibrosis, often with periportal fibrosis. Neonatal hepatitis-like features (inflammation, giant cells, necrosis) varied. In 2 of the 5 patients with paired specimens obtained >6 months apart, lobular and portal fibrosis worsened. Transmission electron microscopy (EM) in all 9 patients studied showed canalicular dilatation, microvilli loss, abnormal mitochondrial internal structure, and varying intracanalicular accumulation of finely granular bile. Canalicular staining for BSEP was absent in 10 patients and present in 2 patients, 1 of whom had intermittent symptoms. ABCB11 sequencing of all patients identified 6 novel and 10 previously described mutations, with nonsense, missense, and/or noncoding mutations in the 10 patients without immunohistochemically demonstrable BSEP. Missense and/or noncoding mutations were identified in the 2 patients with demonstrable BSEP, whose clinical course was more indolent. Mutations ending ABCB11 transcription appear linked, through hepatocellular necrosis and fibrosis, to worse outcome. In conclusion, light microscopy and electron microscopy findings in clinical PFIC2 can support diagnosis, but are variable and nonspecific. Therefore, no correlation between specific mutations and histopathology is yet possible.The American journal of surgical pathology 05/2011; 35(5):687-96. DOI:10.1097/PAS.0b013e318212ec87 · 4.59 Impact Factor
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ABSTRACT: Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and progression in mouse models of the disease. However, the mechanistic link between inflammatory damage and PDA initiation is unclear. Using a Kras-driven mouse model of PDA, we establish that the inflammatory mediator Stat3 is a critical component of spontaneous and pancreatitis-accelerated PDA precursor formation and supports cell proliferation, metaplasia-associated inflammation, and MMP7 expression during neoplastic development. Furthermore, we show that Stat3 signaling enforces MMP7 expression in PDA cells and that MMP7 deletion limits tumor size and metastasis in mice. Finally, we demonstrate that serum MMP7 level in human patients with PDA correlated with metastatic disease and survival.Cancer cell 04/2011; 19(4):441-55. DOI:10.1016/j.ccr.2011.03.002 · 25.29 Impact Factor
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ABSTRACT: Pancreatic ductal adenocarcinoma (PDA) is a lethal disease. Overall survival is typically 6 months from diagnosis. Numerous phase 3 trials of agents effective in other malignancies have failed to benefit unselected PDA populations, although patients do occasionally respond. Studies in other solid tumors have shown that heterogeneity in response is determined, in part, by molecular differences between tumors. Furthermore, treatment outcomes are improved by targeting drugs to tumor subtypes in which they are selectively effective, with breast and lung cancers providing recent examples. Identification of PDA molecular subtypes has been frustrated by a paucity of tumor specimens available for study. We have overcome this problem by combined analysis of transcriptional profiles of primary PDA samples from several studies, along with human and mouse PDA cell lines. We define three PDA subtypes: classical, quasimesenchymal and exocrine-like, and we present evidence for clinical outcome and therapeutic response differences between them. We further define gene signatures for these subtypes that may have utility in stratifying patients for treatment and present preclinical model systems that may be used to identify new subtype specific therapies.Nature medicine 04/2011; 17(4):500-3. DOI:10.1038/nm.2344 · 28.05 Impact Factor
Article: Design and Validation of the Biliary Atresia Research Consortium Histologic Assessment System for Cholestasis in Infancy[Show abstract] [Hide abstract]
ABSTRACT: Pathologists participating in the National Institutes of Health-sponsored Biliary Atresia Research Consortium (BARC) developed and then evaluated a standardized system for histologic reporting of liver biopsies from infants with cholestasis. A set of 97 anonymous liver biopsy samples was sent to 10 pathologists at BARC centers. A semiquantitative scoring system that had 16 histologic features was developed and then used by the pathologists, who had no knowledge of clinical history, imaging results, or laboratory data. Interobserver agreement was evaluated statistically. Agreement on scoring of each feature and on the pathologists' diagnosis, compared with the final clinical diagnosis, was evaluated by using weighted kappa statistics. There was moderate to substantial interobserver agreement in identification of bile plugs in ducts, giant-cell transformation, extramedullary hematopoiesis, and bile duct proliferation. The pathologists' diagnosis of obstruction in clinically proven cases of biliary atresia (BA) ranged from 79%-98%, with a positive predictive value of 90.7%. Histologic features that best predicted BA, on the basis of logistic regression, included bile duct proliferation, portal fibrosis, and absence of sinusoidal fibrosis (each P<.0001). The BARC histologic assessment system identified features of liver biopsies from cholestatic infants, with good interobserver agreement, that might be used in diagnosis and determination of prognosis. The system diagnosed BA with a high level of sensitivity and identified infants with biliary obstruction with reasonable interobserver agreement. However, distinguishing between BA and disorders such as total parenteral nutrition-associated liver disease and alpha(1)-antitrypsin deficiency is not possible without adequate clinical information.Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 04/2011; 9(4):357-362.e2. DOI:10.1016/j.cgh.2011.01.003 · 5.64 Impact Factor
Article: Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl[Show abstract] [Hide abstract]
ABSTRACT: Liposarcoma is a soft-tissue sarcoma typically seen in adults. It is extremely rare in children. It most often occurs in the extremities or in the retroperitoneum. We present a very rare case of an anterior mediastinal liposarcoma of the pleomorphic subtype in a 17-year-old girl, along with radiological and pathological correlation. The location, patient age and histological subtype are exceedingly uncommon for this tumor.Pediatric Radiology 12/2010; 40 Suppl 1(S1):S68-70. DOI:10.1007/s00247-010-1797-1 · 1.65 Impact Factor
Article: Age at Orchiopexy and Testis Palpability Predict Germ and Leydig Cell Loss: Clinical Predictors of Adverse Histological Features of Cryptorchidism[Show abstract] [Hide abstract]
ABSTRACT: We determined the relationship between clinical variables and testicular histopathological changes associated with decreased fertility potential in children with cryptorchidism. Testis biopsies of 274 children who underwent orchiopexy and concurrent testicular biopsy between 1991 and 2001 were analyzed for germ and Leydig cell loss, and testicular fibrosis. Multivariable logistic regression was used to determine if age at orchiopexy (analyzed as continuous and ordinal variables), preoperative testis palpability, unilateral vs bilateral disease and/or side of undescended testis was predictive of these pathological outcomes. Age at orchiopexy was associated with germ and Leydig cell depletion. Each month of testis undescent was associated with development of moderate/severe germ cell depletion (OR 1.02 for each month of age, p <0.005) and Leydig cell loss (OR 1.01 for each month of age, p <0.02). Nonpalpable testes were associated with severe germ cell depletion. Children with palpable testes had lower odds of germ cell depletion than those with nonpalpable testes (OR 0.46, p <0.005). This finding corresponds to a significant 2% risk per month of severe germ cell loss and 1% risk per month of Leydig cell depletion for each month a testis remains undescended, and a 50% greater risk of germ cell depletion in nonpalpable relative to palpable cryptorchid testes. Testes that remain undescended are associated with progressive loss of germ and Leydig cells, and nonpalpable testes predict severe germ cell loss.The Journal of urology 06/2009; 182(2):704-9. DOI:10.1016/j.juro.2009.04.032 · 3.75 Impact Factor
Article: CRYPTORCHIDISM AND MALE FERTILITY POTENTIAL: CLINICAL PREDICTORS OF ADVERSE HISTOLOGICAL FEATURESThe Journal of Urology 04/2009; 181(4):119-119. DOI:10.1016/S0022-5347(09)60341-4 · 3.75 Impact Factor
Article: Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction.[Show abstract] [Hide abstract]
ABSTRACT: Chemoresistance in neuroblastoma is a significant issue complicating treatment of this common pediatric solid tumor. MYCN-amplified neuroblastomas are infrequently mutated at p53 and are chemosensitive at diagnosis but acquire p53 mutations and chemoresistance with relapse. Paradoxically, Myc-driven transformation is thought to require apoptotic blockade. We used the TH-MYCN transgenic murine model to examine the role of p53-driven apoptosis on neuroblastoma tumorigenesis and the response to chemotherapy. Tumors formed with high penetrance and low latency in p53-haploinsufficient TH-MYCN mice. Cyclophosphamide (CPM) induced a complete remission in p53 wild type TH-MYCN tumors, mirroring the sensitivity of childhood neuroblastoma to this agent. Treated tumors showed a prominent proliferation block, induction of p53 protein, and massive apoptosis proceeding through induction of the Bcl-2 homology domain-3-only proteins PUMA and Bim, leading to the activation of Bax and cleavage of caspase-3 and -9. Apoptosis induced by CPM was reduced in p53-haploinsufficient tumors. Treatment of MYCN-expressing human neuroblastoma cell lines with CPM induced apoptosis that was suppressible by siRNA to p53. Taken together, the results indicate that the p53 pathway plays a significant role in opposing MYCN-driven oncogenesis in a mouse model of neuroblastoma and that basal inactivation of the pathway is achieved in progressing tumors. This, in part, explains the striking sensitivity of such tumors to chemotoxic agents that induce p53-dependent apoptosis and is consistent with clinical observations that therapy-associated mutations in p53 are a likely contributor to the biology of tumors at relapse and secondarily mediate resistance to therapy.Neoplasia (New York, N.Y.) 12/2008; 10(11):1268-74. · 5.40 Impact Factor
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ABSTRACT: beta-Catenin signaling within the canonical Wnt pathway is essential for pancreas development. However, the pathway is normally down-regulated in the adult organ. Increased cytoplasmic and nuclear localization of beta-catenin can be detected in nearly all human solid pseudopapillary neoplasms (SPN), a rare tumor with low malignant potential. Conversely, pancreatic ductal adenocarcinoma (PDA) accounts for the majority of pancreatic tumors and is among the leading causes of cancer death. Whereas activating mutations within beta-catenin and other members of the canonical Wnt pathway are rare, recent reports have implicated Wnt signaling in the development and progression of human PDA. Here, we sought to address the role of beta-catenin signaling in pancreas tumorigenesis. Using Cre/lox technology, we conditionally activated beta-catenin in a subset of murine pancreatic cells in vivo. Activation of beta-catenin results in the formation of large pancreatic tumors at a high frequency in adult mice. These tumors resemble human SPN based on morphologic and immunohistochemical comparisons. Interestingly, stabilization of beta-catenin blocks the formation of pancreatic intraepithelial neoplasia (PanIN) in the presence of an activating mutation in Kras that is known to predispose individuals to PDA. Instead, mice in which beta-catenin and Kras are concurrently activated develop distinct ductal neoplasms that do not resemble PanIN lesions. These results demonstrate that activation of beta-catenin is sufficient to induce pancreas tumorigenesis. Moreover, they indicate that the sequence in which oncogenic mutations are acquired has profound consequences on the phenotype of the resulting tumor.Gastroenterology 08/2008; 135(4):1288-300. DOI:10.1053/j.gastro.2008.06.089 · 12.82 Impact Factor
Article: Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor[Show abstract] [Hide abstract]
ABSTRACT: Inflammatory myofibroblastic tumor (IMT) is a distinctive spindle cell lesion and occurs primarily in soft tissue. Recent evidence suggests a neoplastic nature, although historically, both neoplastic and nonneoplastic processes were combined in this category. Originally described as a nonneoplastic process, the term inflammatory pseudotumor (IP) has been used synonymously with IMT. IMTs have been linked to ALK gene (2p23) rearrangements, and some have suggested an association with the human herpesvirus 8 (HHV-8). IMT in the central nervous system (CNS) is rare, its characteristics are poorly defined, and its relation to similar tumors at other sites is unclear. To better characterize IMT within the CNS, we studied clinicopathologic features of 6 IMTs and compared them with 18 nonneoplastic lesions originally classified as IP. The IMT group consisted of 2 male and 4 female patients with a median age of 29 years. Of the six IMTs, 5 occurred within the cerebral hemispheres, and one was in the posterior fossa. All tumors were composed of neoplastic spindle cells and a variable amount of inflammatory infiltrate. Eighteen IPs included in this study consisted of predominantly inflammatory masses occasionally seen in the setting of systemic diseases. Only 1 IMT and none of the IPs recurred during the follow-up period. Four IMTs had either ALK protein overexpression or 2p23 rearrangement, and 1 case demonstrated both. None of the IPs were positive for ALK. Neither IMT nor IP cases demonstrated HHV-8 expression. We suggest that IMT in the CNS is distinct from the nonneoplastic IP, and distinguishing IMT from nonneoplastic lesions should enable better decisions for patient management.Human Pathlogy 04/2008; 39(3):410-9. DOI:10.1016/j.humpath.2007.07.012 · 2.81 Impact Factor
Article: Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves' disease[Show abstract] [Hide abstract]
ABSTRACT: This case describes a young girl with Graves' disease, who presented with fulminant hepatic failure 9 months into propylthiouracil (PTU) therapy. Her clinical presentation was consistent with 'probable autoimmune hepatitis,' as defined by the International Autoimmune Hepatitis Group scoring system. Despite discontinuation of PTU and high-dose steroid therapy, she required liver transplantation. Subsequent pathology could not definitively rule out autoimmune hepatitis. PTU is an important cause of drug-related liver failure in children, and clinicians should be mindful that it is frequently used in patients who already have an underlying risk of autoimmune liver disease.Pediatric Transplantation 07/2006; 10(4):525-8. DOI:10.1111/j.1399-3046.2006.00487.x · 1.63 Impact Factor
Article: BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer.[Show abstract] [Hide abstract]
ABSTRACT: Mucinous colorectal cancer (CRC) has been reported to have distinct clinicopathological and genetic characteristics. However, the incidence and the relationship among microsatellite instability (MSI), CpG island methylator phenotype (CIMP) and BRAF and KRAS mutations in mucinous and non-mucinous CRC are not known. Activating mutations of BRAF and KRAS and their relationship with MSI and CIMP were examined in 83 sporadic CRC specimens (26 mucinous and 57 non-mucinous CRC). MSI, CIMP, BRAF and KRAS mutation were observed in 17, 24, 25 and 36% of the tumors, respectively. BRAF mutation was highly correlated with MSI (p < 0.001) and CIMP (p < 0.001). A higher incidence of MSI (27% vs. 12%), CIMP (38% vs. 18%, p < 0.05) and BRAF mutation (46% vs. 16%, p < 0.01) was observed in mucinous CRC. KRAS mutation (27% vs. 40%) was observed more frequently in non-mucinous CRC. Significantly higher percentages of mucinous CRC (54%, p < 0.05) had MSI or CIMP or BRAF mutations. Concordant occurrence of 2 or more of these alterations was observed in 39% of mucinous CRC and only 11% of non-mucinous CRC (p < 0.01). The more frequent occurrence and closer association among MSI, CIMP and BRAF mutation in mucinous CRC observed in our study further supports the idea that its pathogenesis may involve distinct genetic and epigenetic changes.International Journal of Cancer 06/2006; 118(11):2765-71. DOI:10.1002/ijc.21701 · 5.01 Impact Factor
Top Journals
- Pancreas (2)
- Gastroenterology (1)
- International Journal of Cancer (1)
- The Journal of Urology (1)
- Human Pathlogy (1)
University of California, San Francisco
San Francisco, California, United States
- • Division of Hospital Medicine
- • Department of Pathology
Baylor College of MedicineHouston, Texas, United States
San Francisco VA Medical CenterSan Francisco, California, United States


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hf Chocolates supply fine quality chocolate and confectionery to the retail trade and others who wish to buy wholesale quantities. We are pleased to present our 2015 All Year selection alongside our seasonal Valentine's Day and Easter lines.
If you wish to register for an account to gain access to our pricing or to download a copy of our All Year and/or Valentine's and Easter 2015 brochures, please register here.

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SearchHome » Articles » Extended Analysis
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Friendly Koi Video.
A little tourist was visiting yesterday and it was
the first nice day in a solid week of rain.
The little guy favors the orange koi 'Sunny' and only
wants to feed him.
I said in another thread -- that if our
koi could breathe out of water, they would be waiting
me at the back door each morning. really!
Here is a link that might be useful: Little Tourist & Friendly Koi
OMG what a cute video! I love the way the little tourist gets the food nice and wet before he tries to feed the Koi. How fun is that for a kid? I am sure it will be a special memory for him.
Joan I love the way your pond looks. Reminds me of the Koi ponds I have seen in Hawaii. Very tropical looking, crystal clear with big, healthy Koi. Keep up the good work and keep the videos coming. :)


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World |
Yemen says 37 militants killed in southern army offensive: Saba
ADEN, Yemen
ADEN, Yemen (Reuters) - Yemen said on Sunday 37 al Qaeda fighters had been killed in heavy clashes between the army and the militants in the southern Shabwa province.
The state news agency Saba quoted a military source as saying most of those killed in the fighting on Sunday were Saudis, Afghans, Somalis and Chechens and other nationalities. The source also said the army destroyed a number of vehicles and weapons belonging to the militants.
(Writing by Yara Bayoumy; editing by Sami Aboudi and Andrew Roche)
Our top photography from the last 24 hours. Slideshow


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Auburndale, New York, 11365
Commute to Downtown Elmont
Most errands can be accomplished on foot.
Many nearby public transportation options.
Flat as a pancake, some bike lanes.
Score Details
This location has a Walk Score of 88 out of 100. This location is Very Walkable so most errands can be accomplished on foot.
This location is in the Auburndale neighborhood in New York. Nearby parks include Fresh Meadows Park, Underhill Playground and Holy Cow Playground.
Explore how far you can travel by car, bus, bike and foot from this location.
This location has good transit which means many nearby public transportation options. Car sharing is available from RelayRides.
Rail lines:
Port Washington
1.3 mi
Bus lines:
Q30 Little Neck or Queensborough Community College - Jamaica
0.1 mi
Q88 Elmhurst - Queens Village
0.1 mi
Q17 Flushing - Jamaica
0.1 mi
Q31 Bayside - Jamaica
0.2 mi
Car shares:
View all Auburndale apartments on a map.
Popular apartment searches include pool, hardwood floor and furnished.
This location is in the Auburndale neighborhood. Auburndale is the 157th most walkable neighborhood in New York with a neighborhood Walk Score of 77.
Moving to New York from another city? View our moving to New York guide.


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Mocha Cigars with Coffee Cream
These delicate, airy confections could even be called ladylike -- perfect for showers or luncheons.
- Yield: Makes about 4 dozen
Source: Martha Stewart Living Television, May 1999
- 2 cups confectioners' sugar, sifted
- 1 1/4 cups all-purpose flour, sifted
- 1/8 teaspoon salt
- 1 vanilla bean, split and scraped of seeds
- 10 tablespoons (1 1/4 sticks) unsalted butter, melted and cooled
- 6 large egg whites, room temperature
- 1 tablespoon heavy cream
- 3 ounces bittersweet chocolate
- Coffee Cream
Heat oven to 400 degrees. Combine sugar, flour, and salt in a bowl; make a well in the center. In another bowl, combine vanilla scrapings and butter. Add vanilla butter, egg whites, and cream to sugar mixture; combine. Using the large holes of a box grater, grate chocolate. Gently fold half the chocolate into batter; reserve remaining chocolate in a small bowl. Cover batter; chill at least 2 hours or overnight.
Trace a 4 1/2-inch circle onto a large, flexible plastic lid, such as one from a coffee can. Using scissors, cut lip from lid. Using a utility knife, cut out the traced circle to make a stencil.
Place a Silpat on work surface. Place stencil on Silpat. Using a spatula, spread about 2 teaspoons batter to fill circle. Repeat process, making three more circles. Remove stencil; transfer Silpat to baking sheet.
Transfer baking sheet to oven; bake 2 1/2 minutes. Rotate pan; bake 2 1/2 minutes more, or until golden brown. Working quickly, use a spatula to remove cookies from Silpat; roll each around the handle of a wooden spoon. Remove from spoon; let cool on wire rack. (If cookies harden before rolling, return tray to oven for 30 seconds or until pliable.)
Using a pastry bag fitted with a 3/8-inch plain round pastry tip, fill with coffee cream. Pipe cream into one end of cookie until it is full. Dip each end in chocolate shavings; serve immediately.
Cook's Note
Reviews (2)
toby greenhorn 23 May, 2013
My wife recently joined an organization that aims to run green campaigns to curb activities that hurt the environment, which includes strictly enforcing the smoke ban on public places. Initially, it was not well-received by the public, but because of the strong support from the local government and state authorities, these green movement campaigns were implement and strictly adhered to.
toby greenhorn 23 May, 2013
I recall that the reviews of these campaigns were great and they managed to win the public's attention and support. They held a small celebration in the office, my wife made these mocha cream puffs (instead of the cigar shape) to celebrate the occasion.


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Neil Cleeveley: local infrastructure must show why it is valuable
26 Mar 2015
Navca's chief executive Neil Cleeveley tells Kirsty Weakley that local infrastructure bodies need to...
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Wealthy people are less likely to take risks in philanthropy than in
investment. But with encouragement, this could be changed, argue Jen
Shang and Adrian Sergeant.
Little will come from simple storytelling and we should stop being so naive, say Stephen Pidgeon and Pauline Lockier. It is drama that will change the world.
Charities need to learn from commercial business models in order to maximise their fundraising operations, says Duncan Souster, especially when it comes to dealing with major donors.
JustGiving's Anne-Marie Huby explains the importance of big data in personalising donors' online experience.
A lack of understanding among donors of how gift aid works is potentially costing charities millions of pounds each year. Organisations need to rethink how they put forward gift aid and make sure that it is inbuilt in the donation process, explains Andrew O'Brien.
Bored of the same old fundraising techniques? Change.org's Ben Carter offers some advice on how to have an innovative and dynamic 2015.
Donors are being lost as fast as they're being recruited. The sector's future depends on mastering retention; Roger Craver explains how.
Age UK and the drinks company Innocent first teamed up for the Big Knit over ten years ago. Their relationship is still going strong and last year a record one million little knitted hats adorned smoothie bottles around the UK. Hannorah Lee explains how they keep the partnership fresh.
Charity retailers are consistently coming up with interesting and innovative ways to promote sustainable shopping, from specialist stores to vintage boutiques at festivals. Amy Valentine and Emma Vithlani share tips on tapping into the continuing trend for pop-up shops.
2013 Charity Shops Survey
from £75.00
Directors of Fundraising Survey 2013
from £35.00
26 Mar 2015
Navca's chief executive Neil Cleeveley tells Kirsty Weakley that local infrastructure bodies need to...
19 Mar 2015
Kate Rogers analyses the story behind the Budget announcement of a new Charity Authorised Investment Fund...
10 Mar 2015
With a value of £18bn, the Wellcome Trust's investment portfolio is the largest of all UK charities....
13 Mar 2015
The January issue of Governance carried an article about the relationship between the key board member...
12 Jan 2015
Three years ago Clic Sargent was facing a big black hole in its finances. Jonathan Plumtree explains what...
12 Jan 2015
Gill Slocombe, chair of Girlguiding, describes how this very large membership body adapted its governance...
13 Mar 2015
A British Council poll recently declared the invention of the internet the most momentous event of the...
12 Mar 2015
Social media is here to stay. Roberta Doyle weighs up the positive and negative aspects that trustees...
1 Mar 2015
As the number of fines increases, data protection is becoming an increasingly important issue for boards,...
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Learn – Network – Grow
In a Community ofFundraising Peers
Email: email@example.com
GASP - Grantwriters' Anxiety Support Program
Grantwriters' Anxiety Support Program (GASP) helps new and intermediate grant writers (0-3 year's experience) build confidence and skill in their work. It also provides information for newer development and executive directors and grants managers.
GASP is an opportunity:
▪ To gain an overview of and practical details on topics of interest in the grant
seeking process.
▪ To gain an overview of institutional funding in particular fields.
▪ To develop new professional relationships and advance careers.
▪ To share in-process proposals with peers and "mentors" who offer
feedback—when announced.
Program Date: Quarterly
Offered in San Francisco and other East Bay locations (see program information).
Presented by Development Executives Roundtable (DER)
GASP is offered at no-cost to participants
Monitoring Grants and the Projects They Fund
Date & Time:
Monday, March 9, 2015
Foundation Center
312 Sutter Street, Ste. 606
San Francisco, CA 94108
To Register:
Monitoring Grants and the Projects They Fund will address issues and problems that can arise after a program/project is funded that jeopardize promised outcomes and future funding. Development directors, grants managers and grant writers must sometimes intercede for timely hiring of staff, adequate evaluation, and the overall honest running of programs. This panel will include individuals who know these issues and strategies for addressing them from program, fundraising, administrative and grantmaking points of view, as well as from experiences in small to large organizations. Bring your questions. Workshop will include 30 minutes for networking.
Valentin Aguirre, Senior Grant Writer, Shanti
Valentin came to the Bay Area to study English/writing—and found a vibrant gay Latino community mobilizing against AIDS. He has worked at Mission Neighborhood Health Center, Community United in Response to AIDS/SIDA and LYRIC, has experience as a HIV health educator and a fundraiser for health programs and the arts. Valentin has done grant monitoring for foundation and corporate grants and event sponsorships.
Liz Boskovich, Sr. Director of Development, YMCA of San Francisco
Liz has 13 years experience in public relations, marketing and fundraising in positions of increasing responsibility. At the YMCA of San Francisco since 2012, she coordinates and consolidates asks to large Corporate and Foundation donors and serves as a resource to branch personnel for best practices associated with corporate and foundation relations.
Chuck Flacks, Sr. Manager Healthcare Programs, Jewish Vocational Services (JVW)
Before coming to JVS, Chuck, a seasoned non-profit executive, worked at San Diego Workforce Partnership, Greater San Diego Area. There he developed a strong labor market strategy and brand for the agency, researched projects, collaborated with numerous public and private entities on labor market/economic development research, and increased research grants by 15%.
Bethany Herron, Institutional Grants Manager, Berkeley Repertory Theatre
Bethany has served as Berkeley Rep's Institutional Grants Manager since 2011 and before that as Development Manager for Environmental Traveling Companions. She wrote her first grant proposal at nineteen, after enrolling in SFSU's Technical and Professional Writing Program, and has been using her writing skills to support causes close to her heart since then.
Moderator, Paula Randall, Grants/Fundraising Consultant, DER Board and GASP Co-Chair
Paula has extensive experience as a program developer, educator and director, an evaluator and fundraiser. She has directed and monitored everything from small one-year foundation grants to multi-year federal grants, and seen this work carried out in many ways: good, bad and ugly. Paula has worked passionately in substance and child abuse prevention, health/wellness education, women's and elders' rights.
Registration information:
There is no charge to attend GASP sessions, however, space is limited and advance registration is required by March 8, 2015.


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A user-driven community that provides MMA fighter stats, records, bio, and MMA events, and fight card. Includes all organizations such as UFC and Bellator.Haris BacicPosted in Web Design → Sport
A one-page site for an Austrian psychotherapist. I like the clean, minimalism style and responsive layout.David BernhardPosted in Web Design → Corporate
A gorgeous dial design that makes an immediate impact. It would be difficult to fit into an interface, but works well as an intriguing venture into perspective in interface design.Posted in Interface → Element
A minimal but distinctive logo design that makes a strong impact with its use of black and white.Posted in Branding → Logo
A top seller for the week on themeforest. Built on bootstrap with relaxing tones and two color schemes. Has an extensive documentation and easy to customize.Tamik SozievPosted in Web Design → Design
Web Design Studio and Web Design Blog for Web Designers.Shahzad AnjumPosted in Web Design → Design
Artwork for Horace Dediu's upcoming @5by5 show. A superb design that perfectly fits the 5by5 aesthetic while making a statement of its own.Posted in Branding → Logo
New project for freelancers and my first iOS shot. What do you think?Tomas JerabekPosted in Interface → iPhone App
An extremely crisp power button design that would work well in a huge variety of interface designs. A particularly like the use, and in some areas, absence of texture.Posted in Interface → Element
This designer is going for an intriguing middle-ground between a skeuomorphic Braun-Design-like style, and a clean digital interface. I love the result, it's clean yet has a sense of weight and history.Posted in Interface → Element
A solid texture helps to give an app a distinctive feel, I love the depth of this wooden design.Posted in Interface → iPad App
A simply superb example of varied, yet gorgeous, icon design. I love the subtle differences that help to add detail and definition to each individual icon.Posted in Interface → Element
My new personal portfolio and branding which I just launched. I decided to go for a much cleaner design than I did with my previous one. The website is fully responsive also.Patrick MannPosted in Web Design → Portfolio
Catapulpe is a french digital agency created in 2009. We focus on crafting simple, clean & pixel perfect websites.Catapulpe CatapulpePosted in Web Design → Portfolio
I designed this as a concept logo for a photography expo.Jon SchearPosted in Branding → Logo
A bold logo that uses recognisable imagery to create a distinctive mark. I like the hints at detail and the intriguing use of such a geometric idea with an animal.Posted in Branding → Logo
A great logo design that uses geometric shapes to create a distinctive form that makes an impact. I like the choice of colours but am a little unsure about the use of shadow.Posted in Branding → Logo
A simply excellent site for a new business that takes an intriguing approach to layout and immediately grabs your attention.Posted in Web Design → Design
A beautiful example of how typography can form the entirety of a brand's identity. I love the silky lines and how the grace of the hand-drawn lettering mirrors the name of the company.Posted in Branding → Logo
A simply gorgeous, and effortlessly minimal, site for a web design agency. They manage to give an extremely strong idea of their design aesthetic without having to explain it.Posted in Web Design → Design


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Luke James - Whispers In the DarkThu, Dec 13, 2012 Mix Room
"Oh God" stands out as one of the set's highlights, showcasing a cool confidence in a love's return. The sexy "Heartbeat" and "Strawberry Vapors" get poetically x-rated, and a song about avoiding drama is found in "The Blues," which uses a "Martin" show sample over a traditional blues swing. "Mo' Better Blues" is an emotional ballad that finds James having to choose between two women.
Predominately produced New Age Rock Star's label head Danja, James' flawless vocal performance leaves you hoping he saves up more hotness for his debut album!
Listen and download:


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Spring, Summer and the Kentucky Durby are just around the corner and that means it's time for some sexy hats! Anda & Masha hats are perfect for any occasion. The designs are chic, classic and timeless. A-lister, Drew Barrymore is a fan of the Anda & Masha by Selima Keith Hat. This news boy inspired hat is great for blocking your face from some UV rays, covering up a bad hair day or just accessorizing your favorite outfit. If you want to glam it up a bit, try the Anda & Masha by Selima My Old Man Felt Hat or the Anda & Masha Anita Hat. Pair either of these with a boho chic top, bell bottoms and some Koolaburra sandals and you're ready, set, go for Summer!
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- Want Beyoncé's sweet Illesteva shades? Shop her Leonard II sunglasses in Safari here: http://t.co/1g0uKaJq1Y http://t.co/u13IwWTUEv
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Maryland vs. Florida State
No. 8 Florida State defeated No. 25 Maryland, 63-0, at Doak Campbell Stadium in Tallahassee, Florida.
USA vs. Switzerland men's soccer friendly Top 15 fantasy second basemen WWE WrestleMania 31 Women's NCAA Touranment: No. 1 Maryland vs. No. 2 Tennessee Getting to know Chris Mullin Women's NCAA Tournament: No. 1 UConn vs. No. 7 Dayton Half Hollow Hills West vs. West Islip 119 pictures tell history of WWE Notre Dame defeats Baylor to advance to Final Four Islanders vs. Red Wings NCAA Tournament: Gonzaga vs. Duke NCAA coaches make the best faces


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Visit create.airbnb.com »
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I'm from Italy but have lived for a couple years in the US, and for almost ten years in Switzerland, where I currently reside. I like to practice sports, follow politics, and enjoy travelling or learning foreign languages.
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Matteo e i suoi familiari sono stati degli ospiti ideali, cordiali e rispettosi. Saranno i benvenuti se vorranno ritornare.
Matteo es una persona muy agradable y simpática!. Sin duda lo volvería a alojar en mi apartamento!.
Matteo spent 4 months at home. He was always respectful, clean and friendly. It was a pleasure.
Absolutely recommended .
Matteo stayed for one month, he was a wonderful guest, very polite, tidy and responsible. I would welcome him again anytime and recomend him as a guest without any hesitation.
We really enjoyed having Matteo stay here. We didn't get to know him as well as we would have liked as he only stayed one night at the end of his trip but he was a really lovely person and as a guest very polite and clean and tidy so we would recommend him to anyone and hope if he ever comes back to Rio that he will stay with us again.
Matteo was lovely and we loved hosting them here in Rio! They're nice people and looked after our place very well. Thanks guys and we hope to see you again soon!


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All About You: Reader Survey
2015 marks my seventh full year of creating content for Deep Space Sparkle. As many of you know, I started out posting some pretty random stuff; art lessons, a few art supply reviews and some pictures of my students. I never really had a plan. It wasn't until around 2013 that I really began to focus on creating intentional content. The stuff you asked me for and the stuff I … Read More →


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The Samples
The Samples Reunion
The Samples will be playing a 25th Anniversary reunion show at the Fillmore Auditorium in Denver, CO on Friday, 12/12/2014 to celebrate the release of the "Blue Album" in 1989 with all original members! We will be playing the Blue Album in its entirety plus songs from other albums as well. This will be a [...]
Relix Magazine Review of "America"
Check out the review of "America" in the June issue of Relix Magazine! With all the group's original members now gone, except for lead singer and songwriter Sean Kelly, it might be tempting to relegate The Samples to the archives of jam-pop history. Fortunately, for longtime fans and new listeners, the latest version of the [...]
The Samples have released our new album, "America". The album is available as a physical CD as well as in digital download form. Please visit our BandCamp site to buy true new album!
The Samples for Free
I have collected well over 300 unreleased Sean Kelly/Samples recordings that I am giving out for free. Just send me your email address to firstname.lastname@example.com and put "unreleased music" in the subject line. I will email you the songs as MP3s. I will send you only a small batch each day until you can catch [...]
Tour Dates
Upcoming Shows 2015
|April 3, 2015
|The Oriental Theater - Denver, CO
Sean Kelly at The Oriental Theater
|Buy Tickets Now
|April 10, 2015
|La Jolla, CA
The Samples – Private Party
|May 8, 2015
|Denver, CO
The Samples – Private Party
|May 15, 2015
|ViewHouse - Centennial, CO
The Samples at The View House
|Free Show!
|June 6, 2015
|Civic Center Park - Denver, CO
The Samples at People's Fair
|Free Show!
|June 13, 2015
|Herman's Hideaway - Denver, CO
The Samples at Herman's Hideaway
|June 20, 2015
|22nd Annual Colorado BBQ Challenge - Frisco, CO
The Samples at the 22nd Annual Colorado BBQ Challenge
|July 15, 2015
|Elway's Cherry Creek - Denver, CO
The Samples at Elway's Cherry Creek
|Free Show!
|July 25, 2015
|Taste of Lincoln Avenue - Chicago, IL
The Samples at Taste of Lincoln Avenue
|July 29, 2015
|Band on the Bricks - Boulder, CO
The Samples at Boulder Band on the Bricks
|Free Show!
|August 7, 2015
|Bull & Bush - Denver, CO
The Samples at Bull & Bush
|August 15, 2015
|Maddie's Biergarten - Castle Rock, CO
The Samples at Maddie's Biergarten Street Party
|August 22, 2015
|Genessee Fire Rescue MDA Benefit - Genessee, CO
The Samples at Genessee Fire Rescue MDA Benefit
|August 29, 2015
|The Well - Kansas City, MO
The Samples at The Well
|September 11, 2015
|ViewHouse - Centennial, CO
The Samples at ViewHouse
|Free Show!
|September 25, 2015
|Fruita Fall Days - Fruita, CO
The Samples at Fruita Fall Days
|September 26, 2015
|Evergreen, CO
The Samples – Private Party


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Arts & Crafts Style Bench
Can someone help me identify the age\value of this item. I like that it looks similar to a Stickly piece, but I know it's not. Thanks for any help you may be able to provide.
Here is a link that might be useful: Bench photos
It's just your basic mission oak bench...likely from the 1920's or 30's.
Very well used looks like it came from a public building...perhaps a train station or a library?
Worth? Around here maybe $40 as is.
Linda C
Does the cushion lift up revealing the type of suspension underneath? If it doesn't, can you peer up underneath and see? Or is it solid bench? Is it real leather?
As Linda implies, I don't think it's anything out of the ordinary, but it looks solid, I like the lines, and as far as the wood part of it goes, looks like it could be easily refinished and make a nice addition to a home. That's also probably what I'd pay for it as it is since I find benches handy in my old home, and use a lot of oak.
I don't know about the value, as its a regional thing, but here in the Northeast you wouldnt see it for less than $100 anywhere, unless there were something structurally wrong with it.
I think we're talking more around 1910-15. By the Sesquicentennial even Stickley had shifted to grafting Colonial Revival details onto their pieces. American Arts and Crafts of this sort was dying out by the twenties.
The through tenon with the pyramidal top disappeared in the teens as far as I know, and it would have been flush with the arm if the piece were later.
Maybe the Mission style is too ubiquitous here in the mid west to have a lot of value. Well I remember the bus station here with benches like that in the waiting room.
If it had something different and neat, it would bring more...but no drawer, the arrangement of the slats is very ordinary...and it needs a fair amount of work.
Refinished with a new cushion I would bet you could get $150 here.
Linda C
I like that it looks similar to a Stickly piece, but I know it's not.
Did you see this Stickley bench on eBay? (and *gulp* the asking price). They have a detailed photo of the underside too - might be handy for reference.
In my area (Chicago) your bench would probably start at min $75, if not more like $100.
Moonshadow, thanks a lot for your post. Maybe I should have turned the bench over. Even if it's not the real deal, it sure looks just like it. I didn't even take a rag to the piece, I think if it was polished, that alone would make it look a lot better. Now I am really interested to see if the seating area is a solid piece of wood like the one on ebay. I will take more photos and update the link.
Thanks again.
You're very welcome, deadpoetnj! I just happened to see it and noticed that tho it's not exactly like yours, there are some very close similarities. (Look closely, you'll see the differences.) I'm kind of curious how the underside compares. Yours might well not be a Stickley, but just thought comparing the real thing to what you have is a good tool for examining subtle similarities and differences as a point of reference and a tool for learning! ;) I'm not a Stickley collector, so am following along here and learning too! ;)
Here is the updated link to the bench photos.
Here is a link that might be useful: Bench Photos
This is a signed Limbert piece which I see you've now put on ebay. Good luck!
Here is a link that might be useful: Limbert Bench on Ebay


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March 26, 2015 – The University recently extended its Facilities and Administrative (F&A) Cost rates for all three campuses for the period June 1, 2015 continuing through May 31, 2017.
March 23, 2015 – NIH issues Interim General Grant Conditions Implementing New HHS Grant Regulations (Uniform Guidance).
March 23, 2015 – Effective 2/12/15, four document types (Proposal, Award/Contract, Budget/Justification and Closeout) are available for view in DMAS.
January 11, 2015 – NIH eRA Commons and Grants.gov are updating systems this month. As a result, new validations will be performed on electronic application submissions.
January 08, 2015 – ORA will be offering the workshops on January 20 and 26. Please click for additional details.
December 02, 2014 – Archived NIH Notices
October 07, 2014 – University of Miami faculty, administrators and staff are invited to attend the Office of Research Administration (ORA) Quarterly Meetings.
August 11, 2014 – Please view this NIH article to learn how multi-PI applications fare in comparison to single-PI applications.
January 31, 2014 – Personnel shifts have taken place in Post-Award. Please see link for relevant information.
January 31, 2014 – The National Science Foundation has created a new Proposal and Award Policies and Procedures Guide effective December 26, 2014.
November 22, 2013 – University procedures require that all checks related to sponsored programs be processed through the Office of Research Administration's lockbox.


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BBC (ended 2012)
Yeah Myror was pretty rubbish! He was like the worst assassin EVER!
I thought this thread needed reviving, so here's my category:
Name which episode of the third season was the best, and which one was not so good? Based, naturally, on your impressions.
For me the best was: "The Crystal Cave" (epic, foreshadowing, excellent directing, ominous atmosphere)
The not-so-good one was: "The Sorcerer's Shadow" (pretty unnecessary, especially the place which it took near the end of the season, where it was anticlimactic)
I've been rewatching the S3 episodes this week and my opinions are changing. I'm already feeling nostalgic for S3 even though I didn't enjoy it as much as S2.
I loved The Queen of Hearts the most - I never expected how quickly and how well A/G would progress. I thought it would just be lingering looks throughout S3 no public declarations at all.
Worst as in most disappointed - The Eye of the Phoenix because I wanted it to be an A/M buddy type episode - two sides of the same coin - working together. It was more about the Merlin-Gwaine friendship, which is great but I so wanted one episode on A/M the supposed core dynamics of the show.
|pcdsa wrote:
|Worst as in most disappointed - The Eye of the Phoenix because I wanted it to be an A/M buddy type episode - two sides of the same coin - working together.
|dpebbleson wrote:
|Arthur-Merlin was somehow missing this season, I think. I don't mind it much, but I think many fans are watching especially for that, so I understand the qualms they have.
|boom-moo wrote:
I too love Grettir and wish he had a bigger part or hopefully will pop up again. He was my favourite guest character for S3 now that is a new topic...
Favourite: The Crystal Cave, The Coming of Arthur (Parts 1 and 2), and The Tears of Uther Pendragon (Parts 1 and 2)
Least Favourite: Goblin's Gold, Love in the Time of Dragons
Wasn't a big fan of The Changeling either, although I did like Princess Elena.
Best: The tears of Uther Pendragon (both parts), The Eye of the Phoenix, Queen of Hearts (old Merlin ), the Coming of Prince Arthur
Worst: Not a big fan of Goblin's gold like my Merlin a bit darker and more serious
Best has to be the Witchfinder, he was creepy and sinister and Charles Dance played him perfectly.
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Although most nature lovers may agree that walking barefoot on wood beats doing so on concrete, the new materials to be used are actually more environmentally-friendly in many ways. The main reason for this is that boardwalks of the past were made from ipe, amazon forest wood, that results in the destruction of natural habitats as well as emissions produced traveling from one hemisphere of the world to another. It's also generally understood that if storms like Sandy continue to plunder east coast communities, building with traditional boardwalk materials isn't a sustainable solution. Still, it's easy to sympathize with long-time residents who have attachments to the aesthetic of traditional boardwalks. These walkways were not only avenues for beach visitors, but important spaces of socializing for local residents. As one Rockaway teenager put it, "They better rebuild the boardwalk by next summer! That's the only place we have to hang out around here." She also pointed out that the new concrete sections of the boardwalk in the Rockaways typically draw less of a crowd than the wooden parts.
Local beach residents are hoping that their beloved boardwalks are rebuilt as soon as possible, for nostalgic reasons as well as economic. The traditional wooden boardwalks play the important fiscal role of drawing visiting summer tourists to their shores, and for many seaside communities, boardwalks have served as crucial elements of their local economies. The Rockaways only recently began to see new boardwalk eateries pop up along the waterfront, but these small businesses had been doing well and many residents saw them as important actors in a new Rockaway renaissance.
Whether the new concrete and plastic boardwalks will be embraced equally, or whether communities will protest the change, we will have to wait to see.
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Ancient Rome: From the Early Republic to the Assassination of Julius CaesarPaperback Routledge Sourcebooks for the Ancient World
Free delivery worldwide
Dispatched in 3 business days
When will my order arrive?
- Publisher: ROUTLEDGE
- Format: Paperback | 800 pages
- Dimensions: 158mm x 231mm x 46mm | 1,179g
- Publication date: 1 March 2006
- Publication City/Country: London
- Illustrations note: black & white illustrations
- Sales rank: 40,908
Product description
A companion volume to the highly successful and widely used Ancient Greece, this Sourcebook is a valuable resource for students at all levels studying ancient Rome. Lynda Garland and Matthew Dillon present an extensive range of material, from the early Republic to the assassination of Julius Caesar. Providing a comprehensive coverage of all important documents pertaining to the Roman Republic, Ancient Rome includes: source material on political developments in the Roman Republic (509-44 BC) detailed chapters on social phenomena, such as Roman religion, slavery and freedmen, women and the family, and the public face of Rome clear, precise translations of documents taken not only from historical sources, but also from inscriptions, laws and decrees, epitaphs, graffiti, public speeches, poetry, private letters and drama concise up-to-date bibliographies and commentaries for each document and chapter a definitive collection of source material on the Roman Republic. All students of ancient Rome and classical studies will find this textbook invaluable at all levels of study.
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1. Early Republican Rome: 507-264 BC 2. The Public Face of Rome 3. Religion in the Roman Republic 4. The Punic Wars: Rome Against Carthage 5. Rome's Mediterranean Empire 6. Slaves and Freedmen 7. Women and the Family 8. Tiberius and Gaius Gracchus 9. Gaius Marius 10. The Social War 11. Lucius Cornelius Sulla 'Felix' 12. The Collapse of the Republic 13. Civil War and Dictatorship 14. Ancient Sources


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Washington > Seattle > Motorcycle Repair
We found 2 shops in the Seattle, WA area that are related to Suzuki. You can sort these Suzuki results by distance and rating to find the mechanic you're looking for. If you believe there is an error within the Suzuki results for Seattle, WA, please contact us.Sort By:
Meineke located at 1702 SW Roxbury in Seattle, WA services vehicles for Oil Change and Lube, Towing Service, AC and Heating Repair, Auto Repair, Brake Repair, Diagnostic Services, Electrical Repair, Emissions Testing, Engine Repair, Mobile Auto Repair, Motorcycle Fabrication, Motorcycle Inspection, Motorcycle Repair, Electric Car Repair, Transmission Repair, Truck Parts, Truck Repair, Tune up, Dirt Bike Repair, Dual Sport Repair, Motorcycle Service, Scooter Repair, Moped Repair, Motorcycle Accessories, Timing Belt Replacement, Motorcycle Upholstery, Motorcycle Detailing, Mobile Motorcycle Repair, ATV Repair, Motorcycle Parts, Engine Installation, Torque Converter Repair, Transmission Coolers, Performance Upgrades, Snowmobile Repair, Go-Cart Repair, European Car Repair, Tire Repair, Trike Repair. Call (206) 764-0108 to book an appointment or to hear more about the services of Meineke.
Vehicles: Acura, AJS, Alligator, American IronHorse, American LaFrance, Arlen Ness, ATK, Audi, Autocar Company, ...
Twinline Motorcycles located at 2106 S Holgate Street in Seattle, WA services vehicles for Motorcycle Fabrication. Call (206) 768-8686 to book an appointment or to hear more about the services of Twinline Motorcycles.
Vehicles: AJS, Alligator, American IronHorse, Arlen Ness, BMW, Confederate, Covingtons Cycle City, Harley-Davidson, ...
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Bangkok. Nightlife. Siam2nite.
The Ultimate Guide to Bangkok Nightlife
Featured Events
CLAP & 42below present Siam2nite Flashing Lights SWEET SUMMER
On April 3, the Siam2nite Flashing Lights party series returns to DEMO at Thonglor Arena 10 for another episode, this time themed SWEET SUMMER. CLAP & 42Below invite you to embrace the hot weather with a cool party & cold drinks. Expect the best of high-energy EDM by DEMO's Resident DJs and get your pictures taken at the Siam2nite photo backdrop. Dress code: PastelRead More
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Exclusive Interview with DJ TINCMusic Thursday 26.Mar 2015
WATERLAND 2015 in Phitsanulok features as special international guest the Singapore-based female DJ, Producer, Singer & Songwriter TINC. In 2012 she has been the 2nd runner up for Pioneer Digital DJ Battle…
Exclusive Interview with Om UnitMusic Thursday 26.Mar 2015
PHATFUNK & DUBWAY join forces to bring one of the hottest artists in the bass music scene to Bangkok: OM UNIT! He has represented the UK in the DMC World DJ Championships and he has played on BBC Radio…
Exclusive Interview with DJ Bl3ndMusic Friday 20.Mar 2015
ONYX & RETOX SESSIONS bring DJ BL3ND back to Bangkok on occasion of Songkran, after his Thailand Debut at Together Festival in 2014. He is ranked #78 in DJ MAG's Top 100 DJ's list. Expect a crazy live…
Exclusive Interview with Abel RogersMusic Thursday 12.Mar 2015
Johnnie Walker Gold Label Reserve presents the Thailand Debut of French DJ ABEL ROGERS at the recently opened VOGUE Lounge. He is the official DJ of ARMANI/PRIVE Hong Kong - one of four branches of Giorgio…


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All Items > Knives > Folding Knives > Folding Knife by Brand > Schrade (Manual)
Schrade Imperial Sampler Yellow Acrylic Fruit Knife
- Overall Length:8.375"
- Blade Length:3.75"
- Cutting Edge:3.25"
- Blade Thickness:0.09"
- Blade Material:7Cr17
- Blade Style:Drop Point
- Blade Grind:Hollow
- Finish:Satin
- Edge Type:Plain
- Handle Length:4.625"
- Handle Thickness:0.43"
- Handle Material:Acrylic
- Frame/Liner:Brass
- Weight:1.70 oz.
- Knife Type:Manual
- Opener:Nail Nick
- Lock Type:Slip Joint
- Brand:Scorpion Knives
- Model:SS102
- Country of Origin:China
- Best Use:Kitchen
Tuck one into a fruit basket as a thoughtful gift, or add one to a picnic basket for a quick, romantic getaway. You'll find endless uses for this perfect sized tool! Whether peeling an apple, slicing a mango, or cutting up watermelon, you'll find this sampler fruit knife convenient to have in the kitchen or the RV. made of 7Cr17 high carbon stainless steel, this knife will last for years. The durable celluloid handle resists scratching and will look good down the road.
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Indian Tomahawk followed up a maiden win at Dundalk last November with a late surge to capture the Compare Prices At attheraces.com/odds Median Auction Race in a thrilling finish under the all-weather track's lights.
Charlie Longsdon was fulsome in his praise for jockey Noel Fehily after he booted home Greenlaw to a first victory in almost three years at Wetherby.
Numerous injury problems have restricted the nine-year-old to just 15 previous competitive appearances, with his last triumph coming in a Towcester novice hurdle in the summer of 2012.
GABRIAL (Doncaster, nap, 3.45) hasn't always been the most angelic horse in training, but he remains a horse of immense natural talent and can prove that in Saturday's Betway Lincoln.
At GG.COM we love racing, love sports and absolutely love having some fun bets on them. Every week we get some superb, often crazy offers and concessions from bookmakers fighting for our affections, many of which are unmissable!! Don't miss a thing with our guide to the pick of Live offers and sports concessions available right now.
The flat season begins in earnest this Saturday with the £100,000 Lincoln Handicap providing an ideal springboard for the summer ahead. We've worked through the 22 horse field and pinpointed a likeliest winner, two dark horses and a live outsider at the bottom of our horse-by-horse rundown!


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Winnipeg Free Press - PRINT EDITION
Label tries to squelch Lil Wayne's vulgar lyric
NASHVILLE -- Epic Records is going to "great efforts" to take down a new Future remix leaked over the weekend with a vulgar Lil Wayne lyric that has offended the family of Emmett Till.
The New Orleans rapper made a sexual reference to the beating death of Till, a 14-year-old Chicago boy tortured and shot in Mississippi in 1955 for whistling at a white woman. Till's family objected and the Rev. Jesse Jackson reached out to his management, The Blueprint Group, on the family's behalf.
The label issued a statement Wednesday night apologizing for the release of the song.
"We regret the unauthorized remix version of Future's Karate Chop, which was leaked online and contained hurtful lyrics," the statement said. "Out of respect for the legacy of Emmett Till and his family and the support of the Reverend Jesse L. Jackson, Sr. ... we are going through great efforts to take down the unauthorized version."
Epic will release an official version of the song that "will not include such references."
Neither Jackson nor members of Till's family could be reached late Wednesday. A publicist says Lil Wayne has had no comment so far.
He appears briefly on the song, alluding to the black teenager's beating in a way too vulgar to print.
Till, a native of Chicago, was in Mississippi visiting family in 1955 when he was killed. He was beaten, had his eyes gouged out and was shot in the head before his assailants tied a cotton gin fan to his body with barbed wire and tossed his body into the Tallahatchie River. Two white men, including the woman's husband, were acquitted of the killing by an all-white jury.
Till's body was recovered and returned to Chicago where his mother, Mamie Till, insisted on having an open casket at his funeral. The pictures of his battered body helped push civil rights into the cultural conversation in the U.S.
Bob Dylan wrote a song about it: The Death of Emmett Till.
A Facebook posting on the Mamie Till Mobley Memorial Foundation page Wednesday night said Epic Records Chairman and CEO LA Reid had reached out to the family to personally apologize.
-- The Associated Press
Republished from the Winnipeg Free Press print edition February 15, 2013 D5
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text: I am Luba, I live by myself and I rent rooms to guests from around the world. I have 2 children, Lara and Alexis. Lara lives in Buenos Aires and Alexis in Madrid. About my favorite activities, I like to dance Tango, I am keen on computers, specially about reading news on it, and I also like to chat, eat chocolates, drink coffee, go to restaurants, go to the movies and, travel (whenever I can). I also like to go shopping for clothes and shoes (whenever I can too!).