text: tf_name AFP1 AhR aMEF-2 AML1 AML1a AML1b AML1c AML2 AML3 AML3a AML3b AP-1 AP-4 AR AREB6 Arnt ARP-1 ATF ATF-1 ATF3 ATF4 ATF4 (381AA) ATF6 Bach1 Bach2 C/EBP C/EBPalpha C/EBPdelta C/EBPgamma CACCC-binding factor CAR CAR:RXR-alpha Cart-1 CBF(2) CBF-A CBF-B CBF-C Cdc5 Cdx-2 Cdx-3 c-Ets-1 c-Ets-1 54 c-Ets-1 68 c-Ets-2 CHOP-10 Chx10 c-Jun Clox c-Myb COMP1 core-binding factor COUP COUP-TF COUP-TF1 CP1 CP1A CP1C CP2 CREB CREBbeta CRE-BP1 c-Rel CREMalpha CREMbeta CREMgamma CREMtau CREMtau1 CREMtau2 CREMtaualpha CUTL1 delta factor deltaCREB DP-1 E12 E2 E2F E2F+E4 E2F-1 E2F-1:DP-1 E2F-1:DP-2 E2F-2 E2F-3 E2F-4 E2F-4:DP-1 E2F-4:DP-2 E2F-5 E47 E4BP4 E4F1 EGR1 Egr-1 EGR2 EGR3 ELF-1 Elf-1 ER-alpha ER-beta ER-beta1 Evi-1 FOR1 FOR2 FOXA4a FOXC1 FOXC2 FOXD1 FOXD3 FOXE1 FOXF1 FOXF2 FOXH2 FOXI1 FOXI1a FOXJ1 FOXJ1a FOXJ1b FOXJ2 FOXK1a FOXL1 FOXM1a FOXM1b FOXN1 FOXN2 FOXO1 FOXO1a FOXO3 FOXO3a FOXO3b FOXO4 FXR FXR:RXR-alpha FXR-alpha GABP GABP-alpha GABP-beta1 GABP-beta2 GADD 153 GATA-1 GATA-1A GATA-2 GATA-3 GATA-4 GCMa GCMb GCNF GCNF-1 GCNF-2 Gfi-1 GR GR-alpha Hand1 HEB HEN1 HFH-1 HFH-3 HIF-1 Hlf Hmx3 HNF-1 HNF-1A HNF-1B HNF-1C HNF-3alpha HNF-3B HNF-3beta HNF-4 HNF-4alpha HNF-4alpha1 HNF-4alpha2 HNF-4alpha3 HNF-4alpha4 HNF-4alpha7 HNF-4gamma HNF-6alpha HNF-6beta HOXA5 HOXA9 HOXA9a HOXA9B HP1 site factor HSF HTF ICSBP Ik-1 Ik-3 IPF1 IRF-10 IRF-2 IRF-3 IRF-4 IRF-5 IRF-6 IRF-7 IRF-7A IRF-7H ISGF-3 ITF-2 Krox-20 Krox-24 LCR-F1 LEF-1 Lhx3a Lhx3b Lmo2 LXR-alpha LXR-alpha:RXR-alpha LXR-beta LXR-beta:RXR-alpha MAF MafG Max Max1 Max2 MAZ MAZR MEF-2 MEF-2C MEF-2DAB Meis-1 Meis-1a Meis-1b MIF-1 MRF4 MTF-1 MyoD myogenin NERF-1a NF-1 NF-1/L NF-1/Red1 NF-1A1 NF-1B1 NF-1B2 NF-1C2 NF-1X NF-A NF-E2 NF-E2 p45 NF-EM5 NF-kappaB NF-kappaB1 NF-kappaB1 precursor NF-kappaB2 NF-kappaB2 (p49) NF-kappaB2 precursor NF-muE1 NF-TNF NF-Y NF-YA NF-YB NF-YC NGFI-C Nkx2-2 Nkx2-5 NKX2B Nkx3-1 NKX3A NKX3A v1 NKX3A v2 NKX3A v3 NKX3A v4 Nkx6-1 NKX6A N-Myc NRF-1 Nrf2 Nrf2:MafK Nrf2:MafK oct-B2 oct-B3 Olf-1 Pax-1 Pax-2 Pax-2a Pax-3 Pax-4a Pax-4c Pax-5 Pax-6 Pax-8 Pax-9a Pax-9b Pbx-1a PEBP2 PEBP2alphaA PEBP2alphaA1 PEBP2alphaA2 PEBP2alphaB1 PEBP2alphaB2 Pitx2 POU1F1 POU2F1a POU2F1b POU2F1c POU2F2 POU2F2B POU2F2C POU3F2 POU6F1 (c2) PPAR-alpha PPAR-gamma PPAR-gamma1 PPAR-gamma2 PR PTF1-beta PXR-1 PXR-1:RXR-alpha PXR-1:RXR-beta PXR-2 PXR-2:RXR-alpha R RAR-alpha RAR-alpha:RXR-alpha RAR-alpha:RXR-gamma RAR-alpha1 RAR-beta RAR-gamma Rb:E2F-1:DP-1 RelA RFX1 RORalpha1 RORalpha2 RREB-1 RSRFC4 RXR-alpha RXR-beta S8 SF-1 SMAD-3 SMAD-4 Sox-5 SOX-9 Sp3 SREBP-1 SREBP-1a SREBP-1b SREBP-1c SREBP-2 SRF SRF (263 AA) SRF (400 AA) SRF (440 AA) SRF (504 AA) Staf STAT1 STAT1alpha STAT1beta STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 SXR:RXR-alpha Tal-1 Tal-1beta Tax TBP TBP TCF-1(P) TCF-4 TEF Tel-2a Tel-2b Tel-2c TFIIA TFIIA-alpha/beta precursor (ma TFIIA-gamma TFIIB TFIID TFII-I TGIF TTF-1 USF USF-1 USF-1:USF-2 USF2 VBP VDR v-ErbA vHNF-1 vHNF-1A vHNF-1B vHNF-1C v-Jun v-Maf Vmw65 v-Myb XBP-1 Xvent-1 YAP1 YY1 ZID Zta tf_synonyms AFP-1, alpha fetoprotein enhancer binding protein. AhR, Ah receptor, dioxin receptor, XRE-binding factor, aryl hydrocarbon receptor. aMEF2. AML1, PEBP2alphaB, Acute myeloid leukemia 1 protein, Core-binding factor, alpha 2 subunit, RUNX1, CBF-alpha 2, Runt-rela AML1, PEBP2alphaB, RUNX1, CBF-alpha 2. AML1, PEBP2alphaB, PEBP2alphaB1, RUNX1, CBF-alpha 2. AML1, PEBP2alphaB, AML-1B, RUNX1, CBF-alpha 2. AML2, PEBP2alphaC1, CBF-alpha 3, RUNX3, Runt-related transcription factor 3, Core-binding factor, alpha 3 subunit, Acute m Osf2, PEBP2alphaA, AML3, PEBP2alphaA1, Polyomavirus enhancer binding protein 2 alpha A subunit, CBF-alpha 1, RUNX2, PEBP2alpha1, Osf2, PEBP2alphaA, CBF-alpha 1, RUNX2. PEBP2alpha1, Osf2, PEBP2alphaA, CBF-alpha 1, RUNX2. (Jun)2, AP1, Fos/Jun, PEA1, PEA1 (mouse). AP4. androgen receptor, AR, NR3C4, dihydrotestosterone receptor. Nil-2-a, TCF8 (gene name), AREB6, Atp1a1 Regulatory Element Binding protein 6, ZEB, zinc finger E-box-binding protein, neg hypoxia-inducible factor 1beta, aryl hydrocarbon receptor nuclear translocator, HIF-1beta. ARP-1, COUP-beta, apolipoprotein AI regulatory protein, NR2F2, COUP-TF II. ATF. ATF-1, TREB-36. activating transcription factor 3, LRG-21. ATF-4, CREB-2, TAXREB67 homolog, YAVREB67, TR67, C/ATF, mTR67, activating transcription factor 4. ATF-4, CREB-2, TAXREB67 homolog, YAVREB67, TR67, C/ATF, mTR67, activating transcription factor 4. activating transcription factor 6, cyclic-AMP-dependent transcription factor. BTB and CNC homolog 1, transcription regulator protein BACH1. BTB and CNC homolog 2. BPc, CBP, C/EBP, C/EBPalpha, EBP20, CCAAT/enhancer binding protein alpha. BPc, CBP, C/EBP, C/EBPalpha, EBP20, p42(C/EBPalpha), p42C/EBPalpha, C/EBPalpha(p42), CCAAT/enhancer binding prote C/EBPdelta, CELF, CRP3, NF-IL6beta. C/EBPgamma, GPE1-BP, Ig/EBP1, muEBP-E, Ig/EBP-1. CACCC-binding factor, htbeta. NR1I3, phenobarbital receptor, constitutive androstane receptor, MB67 (human). cartilage homeoprotein 1. CBF(2), CBF-A + CBF-B, CCAAT-binding factor, CP1, NF-Y (mouse), NF-YA:NF-YB:NF-YC. CBF-A, CP1-A, HAP3 (yeast), NF-YB (mouse). CBF-B, CP1-B, HAP2 (yeast), NF-YA (mouse). NF-YC (mouse), CP1C (human). PCDC5RP, Pombe Cdc5-related protein, cell division control protein 5. CDX2, caudal homolog homeobox protein 2. Cdx-2, shCdx-2. c-Ets-1, Ets1, p54. c-Ets-1, c-Ets-1 54, Ets1, p54, p54c-Ets-1. c-Ets-1 68, p68c-Ets-1. c-Ets-2, c-Ets-2 58-64, Ets2, p58-64c-Ets-2, Ets-2. CHOP-10, GADD 153 (hamster). HOX10, RET1, C. elegans ceh-10 homeo domain-containing homolog. c-Jun, p39, JunA. CDP, Cux. c-Myb. core-binding factor. COUP, COUP-TF, chicken ovalbumin upstream promoter transcription factor. COUP-TF, chicken ovalbumin upstream promoter transcription factor. COUP, COUP-TF, EAR3, COUP-alpha, NR2F1, chicken ovalbumin upstream promoter transcription factor. alpha-CP1, CBF, CP1, NF-Y, trimer NF-Y, NF-Y complex. CBF-A (rat), CP1-A, HAP3 (yeast), NF-YB (mouse). CBF-C (rat), NF-YC (mouse), HSM-1. alpha-CP2a, alpha-CP2a, alpha-CP2b, CP-2, LSF, SEF-1, alpha-CP2, LBP-1c, SAA enhancer factor 1. CREB, CREBalpha. HB16, TREB-7, XBP-4, XBP4, ATF-2 (human), CREBP1. c-Rel, HIVEN86A, p82(hc-rel), p68. CREM-alpha. CREMbeta. CREMgamma. CREMtau. cAMP-responsive element modulator tau1. cAMP-responsive element modulator tau2. CDP, CCAAT displacement protein, cut homeodomain protein, Cux, cut-like homeodomain protein, Clox. delta-factor, F-ACT1, NF-E1 (2), YY-1, YY1. CREBdelta, deltaCREB. DRTF1-polypeptide-1. A7, E2A. E2. E2F+E4. E2F. a1, E47, shPan1 (hamster), E2A. NF-IL3A. E4F1, E4TF3, EIIA-EF. ETR103, Krox-24, NGFI-A, zif268, Egr-1, early growth response protein 1, AT225. EGR1, Krox-24, NGFI-A, TIS-8, zif268, early growth response protein 1. Krox-20 (mouse), early growth response protein 2, AT591. pilot, early growth response protein 3. Elf-1. E74-like factor 1, Elf1, ETS-related transcription factor ELF-1. ER, estrogen receptor, NR3A1. estrogen receptor beta, NR3A2, ESTRB, ESR2. NR3A2, estrogen receptor beta 1. Evi-1, ecotropic virus integration 1 site protein. FXR-like orphan receptor, FXR-like orphan receptor 1, FOR, FOR-1, FOR 1. FXR-like orphan receptor, FOR, FOR 2, FOR-2, FXR-like orphan receptor 2. XFD-1, Pintallavis. FREAC3, FKHL7. Mesenchyme fork head 1, Fkh-14, Fork head homolog 14, MFH-1. Forkhead RElated ACtivator-4, FKHL8, FREAC4. HFH2, Genesis, HFH-2. TTF-2. HNF-3/Fkh Homolog 8, Freac-1 (Forkhead RElated ACtivator-1), HFH-8. LUN. forkhead activin signal transducer 2, FAST-2, FAST2. Forkhead RElated ACtivator-6, FKHL10, HFH3, FREAC6, HFH-3 (HNF-3/Fkh Homolog 3), HFH-3. Xenopus fork head domain factor 2, XFD2, XFD-2. HNF-3/Fkh Homolog 4, HFH-4. HNF-3/Fkh Homolog 4, FKHL13, HFH-4. FHX.L, fork head homologous X, long isoform. ILF-1, interleukin enhancer binding factor 1, ILF. FKHL11, FREAC7. HNF-3/Fkh Homolog 11A, FKHL16A, HFH-11A. HFH-11B. winged-helix nude, Whn. HTLF, human T-cell leukemia virus enhancer factor. FKHR. ALV, FKHR, FKH1. FKHRL1, FKHR2. FKHRL1. FKHRL1P1. AFX, AFX-1, AFXH. HRR1, NR1H4, retinoid X receptor interacting protein 14, farnesoid X activated receptor, RIP14, BAR, bile acid receptor, RIP-1 HRR1, NR1H4, retinoid X receptor interacting protein 14, farnesoid X activated receptor, RIP14, BAR, bile acid receptor, RIP-1 EF-1A, GABP, NRF-2, nuclear respiratory factor 1, GA binding protein, enhancer-binding factor to the E1A core motif. GABP-alpha, NRF-2alpha, GA binding protein alpha subunit. E4TF1-53, GA binding protein beta1 subunit, NRF-2beta2, nuclear respiratory factor 2beta2. E4TF1-47, GA binding protein beta2 subunit, NRF-2gamma2, nuclear respiratory factor 2gamma2. GADD 153, CHOP, growth arrest and DNA-damage-inducible gene 153. EF1, EFgammaa, Eryf-1, GATA-1, GF-1, NF-E1 (1). GATA-1. GATA-2, NF-E1b (chick). GATA-3, NF-E1c (chick). glial cells missing factor a. glial cells missing factor a. NR6A1, RTR, NCNF, GCNF, GCN, NCN, germ cell nuclear factor, retinoid acid receptor-related testis-associated receptor, ne NR6A1, RTR, NCNF, GCNF, GCN, NCN, germ cell nuclear factor, retinoid acid receptor-related testis-associated receptor, ne NR6A1, RTR, NCNF, GCNF, GCN, NCN, germ cell nuclear factor, retinoid acid receptor-related testis-associated receptor, ne growth factor independence 1. glucocorticoid receptor, GR, NR3C1. glucocorticoid receptor, GR, NR3C1, GR alpha. Thing1, Th1, eHand, Hxt, heart- and neural crest derivatives-expressed 1. HTF4, HTF4A, TCF-12. NSCL1, NSCL-1, NHLH1, pp20(HEN1). HNF-3/Fkh Homolog 1, HFH1. HNF-3/Fkh Homolog 3, HFH3. hypoxia-inducible factor 1. Hlf, hepatic leukemia factor. H6 homeobox 3, NKX5-1, Nkx-5.1. APF, HNF1, HNF-1alpha, LF-B1. APF, HNF1, HNF-1alpha, LF-B1, HNF-1A. LF-B3, TCF-2, vHNF-1, LFB3, vHNF1. Hepatocyte Nuclear Factor 3 alpha, HNF3A. HNF3B, HNF3beta. HNF3beta, XFD-3, XFD3, Xenopus fork head domain factor 3. AF-1, HNF4, hepatocyte nuclear factor 4, NR2A1. AF-1, HNF4, NR2A1, HNF4A. HNF4, HNF-4, hepatocyte nuclear factor 4, hepatocyte nuclear factor 4alpha1, NR2A1. hepatocyte nuclear factor 4alpha2, NR2A1. hepatocyte nuclear factor 4alpha3, HNF-4C, NR2A1. hepatocyte nuclear factor 4alpha4, NR2A1. hepatocyte nuclear factor 4alpha7, NR2A1, HNF-4alphaP2. hepatocyte nuclear factor 4gamma, HNF4G, NR2A2. Hox-1.3, Hoxa-5, Chox-1.3 (chick). Hoxa-9, Hox-1.7, XhoxB1 (Xenopus). HOX1G. HP1 site factor. HSF, HSF1, HTF, mHSF1, heat shock transcription factor 1. hepatocarcinogenesis-related transcription factor. ICSBP, IFN consensus sequence binding protein, IRF-8, IRF8. LyF-1, Ikaros 1. LyF-1, Ikaros 3. insulin promoter factor 1, STF1, somatostatin transactivating factor 1, Pdx1, pancreas/duodenum homeobox 1. IRF10, Interferon regulatory factor 10. IRF-2, PRDI-BFc, PRDI-BFi. INTERFERON REGULATORY FACTOR 3, IRF-3, irf3, IRF3. IRF4, lymphocyte specific interferon regulatory factor, LSIRF, NF-EM5, interferon regulatory factor 4, MUM1. IRF-5, IRF5, Interferon Regulatory Factor 5. Interferon Regulatory Factor 6, IRF-6, IRF6. IRF7, IRF-7, Interferon regulatory factor 7. interferon regulatory factor 7. interferon regulatory factor 7. E factor, factor e, ISGF-3. E2-2, ITF-2, E32, SEF2-1B. EGR2 (human), Krox-20. EGR1, EGR1 (human), ETR103 (human), Krox-24, NGFI-A, TIS-8, zif268. Nrf1 (short form), TCF11. LEF 1, LEF-1L, lymphoid enhancer binding factor 1. Xlim-3 (Xenopus), P-Lim, Lim-3. LIM-only protein 2, RBTN2, Rhombotin-2, TTG-2. NR1H3, RLD1, LXR, oxysterol receptor LXRalpha, liver X receptor alpha, nuclear orphan receptor LXR-alpha, oxysterol recepto pha:RXR-alpha NR1H2, oxysterol receptor LXR-beta, nuclear orphan receptor LXR-beta, ubiquitously expressed nuclear receptor, orphan nucl ta:RXR-alpha mammary activating factor. Myn, Myc-binding novel HLH/LZ protein. Max, Myn (mouse), p21. Myn, p22. Myc-associated zinc finger protein, Pur-1, purine-binding transcription factor 1. MAZ related factor. MEF-2, MEF-2A. MEF2D, MEF-2D, MEF2DAB, MEF-2D isoform AB, MEF-2D (514 AA form) (mouse), MEF-2D isoform 1a (mouse). myeloid ecotropic viral integration site 1. myeloid ecotropic viral integration site 1a, Meis1. myeloid ecotropic viral integration site 1b, Meis1. MIF. herculin (mouse), MRF4, Myf-6 (human). MEP-1, metal element protein-1, MTF-1, metal-regulatory transcription factor 1. MEF1, Myf-3 (human), MyoD, MyoD1. Myf-4 (human), MyoG, myogenin. new ets-related factor, ELF2, ELF2B. CCAAT-binding factor, CCAAT box-binding transcription factor, CTF, NF-1, NF-1 (-like proteins), NF-1-like, NF-I, TGGCA-bind NF1/L, RPF-A (hamster), NF-1A1.1 (chick), NF-I/L. NF-1B1 (chick), NF-1/Red1, NFI-B1, RPF-B. NF-1A1, NFI-A1, RPF-A (hamster). NF-1B1, NF-1/Red1 (hamster), NFI-B1, RPF-B. NF-1B2, NFI-B2. CTF-2 (human), NF-1C2, NFI-C2. NF-1/X, NFI-X. IgNF-A, NF-A, NF-A1, NF-A2, oct-B1A, oct-B1B. NFE2. nuclear factor erythroid 2 p45. NF-EM5, PU.1 interaction partner, Pip, lymphoid-specific interferon regulatory factor, LSIRF-2, interferon regulatory factor 4, IR NF-kappaB, NF-kappaB complex, p50/p65. 243/NFA-kappaB, EBP-1, H2TF1, KBF1, NF-kappaB (p50), p50. KBF1, p110, p105, NF-kappaB1 (p105), NF-kappaB1 (p110). Lyt-10, NF-kappaB2, p52, NF-kappaB2 (p52). p49. H2TF1, p100, p97, p98/p55, NF-kappaB2 (p100), NF-kappaB2 (p97). NF-muE1. NF-kappaB-like factor, NF-TNF. alpha-CP1, CBF(2), CCAAT-binding factor, CP1, CP1 (human, rat), NF-Y, NF-YA + NF-YB, NF-YA:NF-YB:NF-YC. CBF-B (rat), CP1B (human, rat), HAP2 (yeast), NF-YA. CBF-A (rat), CP1a (human, rat), HAP3 (yeast), NF-YB. CBF-C (rat), CP1C (human). NGFI-C, pAT 133 (hu), EGR4, Egr-4. Nkx-2.2, NKX2B. Csx, Nkx-2.5, cardiac-specific homeobox protein. Nkx-2.2, Nkx2-2. Nkx-3.1, NKX3A. Nkx-3.1, NKX3.1. Nkx-3.1, NKX3.1. Nkx-3.1, NKX3.1. Nkx-3.1, NKX3.1. Nkx-3.1, NKX3.1. Nkx-6.1, Nkx6.1, Nkx6A. Nkx-6.1, Nkx6.1. alpha-PAL, alpha-palindrome-binding protein, nuclear respiratory factor 1. NF-E2 related factor 2, NFE2-related factor 2, nuclear factor, erythroid derived 2, like 2, NFE2L2, NRF2, NRF-2. B2 octamer binding factor, oct-B2. oct-B3. Olf-1, Olf1. HuP48 (human), Pax-1, PAX1, mPax-1, mPax1. PAX2, hPax2, hPax-2. Pax-2, PAX2, mPax2, mPax-2. HuP2 (human), PAX3, mPax-3, mPax3. PAX4, mPAX4, Pax-4, mPax-4. PAX4, Pax-4. BSAP, Pax-5, B-cell specific activator protein, PAX5, mPax5, mPax-5. Pax-6, Sey, PAX6, Small eye, mPax-6, mPax6. PAX8, mPax-8, mPax8. Pbx-1, Pbx1, pre B-cell leukemia transcription factor 1a, Prl. CBF, PEA2, PEBP2, PEBP3, core binding factor, polyomavirus enhancer-binding protein 2, MyNF1. Osf2, CBFA1, PEBP2alphaA. PEBP2alpha1, PEBP2alphaA, AML3, CBF-alpha 1, RUNX2. PEBP2alpha2, CBFA1, PEBP2alphaA. AML1, PEBP2alphaB, CBFA2, AML1b. AML1, PEBP2alphaB, CBFA2. Ptx-2, Pitx2, RGS, Otlx2, RIEG, Ptx2. Pit-1, GHF-1, Pit-1b, pituitary-specific positive transcription factor 1, growth hormone factor 1. alpha-H1, IgNF-A, NF-A, NF-A1, NF-III, OBP100, Oct-1, octamer-binding factor, oct-B1A, oct-B1B, OTF-1, TRF. alpha-H1, IgNF-A, NF-A, NF-A1, NF-III, OBP100, Oct-1, octamer-binding factor, oct-B1A, oct-B1B, OTF-1, TRF. alpha-H1, IgNF-A, NF-A, NF-A1, NF-III, OBP100, Oct-1, octamer-binding factor, oct-B1A, oct-B1B, OTF-1, TRF. IgNF-A, NF-A, NF-A2, NF-III, Oct-2, Oct-2A, OTF-2, OTF-2A, Oct-2.2. Oct-2B, OTF-2B, Oct-2.5. Oct-2C. N-Oct-3, Oct-7, Brn-2, Brain-2. Brain-5 (c2), Emb (c2), Brn-5 (c2). peroxisome proliferator-activated receptor, peroxisome proliferator-activated receptor alpha, PPAR, PPARalpha, NR1C1. peroxisome proliferator-activated receptor gamma, PPARgamma, NR1C3. peroxisome proliferator-activated receptor gamma, PPARgamma, NR1C3. peroxisome proliferator-activated receptor gamma, PPARgamma, NR1C3, peroxisome-proliferator-activated receptor gamma 2 progesterone receptor. PTF-1. NR1I2, pregnane X receptor, PXR. NR1I2, pregnane X receptor, PXR. BRLF1, factor R, R, R factor. retinoic acid receptor alpha, NR1B1, RARa. pha:RXR-alpha pha:RXR-gamma RAR-alpha, retinoic acid receptor alpha, NR1B1. RAR-beta, retinoic acid receptor beta, NR1B2. RAR-gamma, retinoic acid receptor gamma. NF-kappaB (p65), Rel-A, p65. EF-C, RFX, RF-X, enhancer factor C. RAR-related orphan receptor alpha1, NR1F1. RAR-related orphan receptor alpha2, NR1F1. Ras-responsive element binding protein 1. RSRFC4. retinoid X receptor alpha, RXR-alpha, NR2B1. H2RIIBP, retinoid X receptor beta, RXR-beta, NR2B2. Prx-2. Ad4BP, NR5A1, steroidogenic factor 1, STF-1, fushi tarazu factor homolog 1. SRY-related HMG-box gene 5. SRY-related HMG-box protein 9, SOX9. SPR-2, SP-3. serum response factor. SRF-I. SRF-S. SRF-M. CArG-binding factor, CBF (3), p67, p67SRF, SRF, serum response factor, SRF-L. Se-Cys tRNA gene transcription activating factor. STAT91, ISGF3alpha p91, signal transducer and activator of transcription 1. STAT91, ISGF3alpha p91. GAF, STAT84, ISGF3alpha p84. STAT113, signal transducer and activator of transcription 2, ISGF3alpha p113. signal transducer and activator of transcription 3, APRF, acute-phase response factor. signal transducer and activator of transcription 4. MGF, signal transducer and activator of transcription 5 A, mammary gland factor, STF-IL-3. MGF, signal transducer and activator of transcription 5 A, mammary gland factor, STF-IL-3. signal transducer and activator of transcription 6. SCL, Tal-1, TCL5, pp42-TAL1, Tal-1alpha, T-cell acute lymphocytic leukemia-1 protein, stem-cell leukemia protein. Tax. TBP, TFIID, TFIIDtau, TATA-binding protein. TBP, TFIID, TFIIDtau, TATA-binding protein. T cell factor 1, TCF-1, TCF-1P, TCF-7, TCF7. Thyrotroph Embryonic Factor. ETS-related protein TEL2, TEL-related ETS factor, TEL2, TELB, Tref. DBF3, TFIIA. TFIIA-LN/LC, TFIIA-L. TFIIA-S. factor e, TFIIB, FA, CB, CI, alpha (rat). TFIID. TFII-I, SPIN, General Transcription Factor II-I, GTF2I, BAP-135. 5 TG3 interacting factor, TG-interacting factor. T/EBP, TTF-1, Nkx2.1, Nkx-2.1. gamma-factor, USF, upstream stimulatory factor. eUSF (duck), MLTF, pf51, UEF, USF, USF1, upstream stimulatory factor. CIIIB1. USF II, USF44, FIP, Fos-interacting protein, upstream stimulatory factor 2. DBP, VBP. VDR, vitamin D receptor, NR1I1, 1,25-dihydroxyvitamin D3 receptor. c-ErbA, c-ErbA-alpha, v-ErbA, c-ErbAalpha. LF-B3, vHNF-1, LFB3, vHNF-1A, vHNF1. HNF-1beta, vHNF-1, vHNF-1A. v-Jun. alpha-TIF, ICP25, Vmw65, VP16. v-Myb. hXBP-1, TREB-5, XBP-1, X-box binding protein 1. AP1, yAP1, PAR1, PDR4, SNQ3, YML007W. 62K protein, delta factor, F-ACT1, MAPF1, NF-E1 (2), Yin and Yang 1, YY-1, NMP-1, nuclear matrix protein 1. zinc finger protein with interaction domain. BZLF1, EB1, ZEBRA, Zta, Z protein. organism human, Homo sapiens mouse, Mus musculus human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens mouse, Mus musculus human, Homo sapiens mouse, Mus musculus human, Homo sapiens mouse, Mus musculus human, Homo sapiens human, Homo sapiens mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus human, Homo sapiens mouse, Mus musculus mouse, Mus musculus clawed frog, Xenopus laevis mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus human, Homo sapiens human, Homo sapiens mouse, Mus musculus mouse, Mus musculus rat, Rattus norvegicus rat, Rattus norvegicus rat, Rattus norvegicus rat, Rattus norvegicus human, Homo sapiens mouse, Mus musculus golden (Syrian) hamster, Mesocricetus auratus mouse, Mus musculus chick, Gallus gallus chick, Gallus gallus mouse, Mus musculus mouse, Mus musculus mouse, 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musculus mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus clawed frog, Xenopus laevis mouse, Mus musculus human, Homo sapiens human, Homo sapiens human, Homo sapiens mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus human, Homo sapiens human, Homo sapiens human, Homo sapiens HTLV-I, human T-cell lymphotropic virus type I human, Homo sapiens mouse, Mus musculus mouse, Mus musculus mouse, Mus musculus human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens human, Homo sapiens mouse, Mus musculus human, Homo sapiens mouse, Mus musculus mouse, Mus musculus chick, Gallus gallus mouse, Mus musculus rat, Rattus norvegicus rat, Rattus norvegicus chick, Gallus gallus mouse, Mus musculus AEV, avian erythroblastosis virus domestic pig, Sus scrofa human, Homo sapiens human, Homo sapiens human, Homo sapiens ASV, avian sarcoma virus AS42, avian musculoaponeurotic fibrosarcoma virus HSV-1, herpes simplex virus type 1 AMV, avian myeloblastosis virus human, Homo sapiens clawed frog, Xenopus laevis yeast, Saccharomyces cerevisiae human, Homo sapiens human, Homo sapiens EBV, Epstein-Barr virus TF ID Organism Organism class TF Name TF Synonym URL Functional Features Structual features Cell specifity belongs to the Granyhea d-like family of TFs, together with Drosophil a Elf- 1/NTF-1 activator factors, [3] and likely appears presents to be novel functionall type of y limiting DNA in nuclear binding B cell recognize extracts alpha- s DNA activates CP2a, elements transcripti alpha- consisting on of CP2a, of two alpha- alpha- directly globin CP2b, repeated gene [8] CP-2, http://local half-sites [9] [6] [7], LSF, SEF- host/cgi- [5] of the 1, alpha- bin/biobas glutamine- major CP2, LBP- e/transfac/ rich acute 1c, SAA mouse, 7.4/bin/get region, phase enhancer Mus vertebrate TFProf.cgi phosphory gene T00152 CP2 factor 1. musculus s ?T00152 lation SAA3 [3]. NULL stimulates basal transcripti on, but is three not subunits: indispens alpha, able for beta, pol II gamma transcrptio [9] alpha n [14] [9] and beta binds to are and processed stabilizes from a TFIID/TB common P-TATA alpha/beta box- complexe precursor s [14] it <T02216> decreases holo- the TFIIA is influence active of either as sequence dimeric s flanking alpha/beta the TATA- + box, http://local gamma casus a host/cgi- or as conformati bin/biobas trimeric onal e/transfac/ alpha+bet change of human, 7.4/bin/get a+gamma TBP and DBF3, Homo vertebrate TFProf.cgi complex neutralize T00817 TFIIA TFIIA. sapiens s ?T00817 [3] [4] s the (HeLa) the N- holo- terminal TFIIA part binds to represent and s the stabilizes alpha, the TFIID/TB C- P-TATA terminal box- part the complexe beta s [11] it is subunit, an the antirepres processin sor by g point displacing being inhibiting located TFIID- around componen position ts [8] [6] 275 [6] [7] [5] and an [3] activator pI(calc.) = through 4.25 [6] interaction processin with g is no some prerequisit other e for TFIID http://local functional componen host/cgi- assembly ts [5] the TFIIA- bin/biobas with the alpha- alpha/beta e/transfac/ gamma subunit TFIIA- human, 7.4/bin/get subunit specificall precursor LN/LC, Homo vertebrate TFProf.cgi [4] [5] the y T02216 (ma TFIIA-L. sapiens s ?T02216 alpha mediates (HeLa) N- terminally extended form is an alternative translation initiation product <T02216> the N- terminal part represent s the alpha, the C- terminal part the beta subunit, the processin http://local g point host/cgi- being TFIIA- bin/biobas located alpha/beta e/transfac/ around human, 7.4/bin/get position precursor Homo vertebrate TFProf.cgi 236 [2] [3] T02217 (mi sapiens s ?T02217 [1] (HeLa) assemble s active holo- TFIIA either with alpha/beta - precursor or with alpha and beta subunits http://local [3] [4] by host/cgi- interacting bin/biobas with the e/transfac/ alpha, but human, 7.4/bin/get not with TFIIA- Homo vertebrate TFProf.cgi the beta T02224 gamma TFIIA-S. sapiens s ?T02224 moiety [4] (HeLa) pI(calc.) = binding to 8.32 [23] (TATA- resemblin DNA)+TFI g the ID(+TFIIA) overall structure enhances of TBP in affinity of exhibiting TBP to also two DNA [13] direct anchors repeats, pol II to basic the initial regions, transcripti and on sigma complex homology [26] may regions fix the [24] [25] transcripti forming a on start protease- site [4] resistant exerts core [21] similar [17] with functionali a ty in structure conjunctio similar to n with http://local that of YY1 host/cgi- cyclin A instead of factor e, bin/biobas [4] [7] the TBP [14] TFIIB, e/transfac/ direct taret of FA, CB, human, 7.4/bin/get repeats certain CI, alpha Homo vertebrate TFProf.cgi (112-316) autoantibo T00818 TFIIB (rat). sapiens s ?T00818 are alpha- dies [11] NULL http://local host/cgi- bin/biobas factor e, rat, e/transfac/ TFIIB, Rattus 7.4/bin/get FA, CB, norvegicu vertebrate TFProf.cgi T02159 TFIIB CI, alpha. s s ?T02159 NULL basic part of region MEF-1 contacts complex DNA, induces HLH hyperphos domain is phorylatio the n of dimerizati MyoD on upon interface associatio [18] binds n induces DNA transcripti avidly as on of IgH, homodime but also r of IgH- (contrastin stimulatin g to E12), g Oct-2 or as gene, and heterodim recombina er [8] tion- from activating crystal genes structure: RAG-1 dimerizati and -2 on thus domain stimulatin http://local forms a g IgH BCF-1, host/cgi- parallel rearrange E2A.E47, bin/biobas four-helix- ment as E2A-E47, e/transfac/ bundle [3] well [12] E47, human, 7.4/bin/get helix 1 is in acute IEBP1 Homo vertebrate TFProf.cgi one turn lymphobla T00207 E47 (rat), E2A. sapiens s ?T00207 longer stic ubiquitous bHLH activator region is (as 87% heterodim identical er with to that of E2A- Hand2 proteins), <T04370> may also [2] no exert homodime repressor rization, function DNA- [7] binding induces depends trophoblas on t heterodim formation erization in [7] the preimplant Hand1- ation bound embryos half-sites while Id-1 (E10.5:) are highly <T00403> portions degenerat inhibits of the Thing1, e [7] trophoblas heart, Th1, Hand1 t autonomic eHand, and differentiat ganglia, Hxt, heart- Hand2 ion [3] gut, and http://local <T04370> role in left pharyngea neural host/cgi- show a chamber- l arches; crest bin/biobas compleme specific (adult:) derivative e/transfac/ ntary cell fate intestine, s- mouse, 7.4/bin/get assymetri decisions lung, expressed Mus vertebrate TFProf.cgi cal and placenta T01569 Hand1 1. musculus s ?T01569 expressio possibly [7] http://local MLTF, host/cgi- UEF, bin/biobas USF, e/transfac/ upstream 7.4/bin/get stimulator vertebrate TFProf.cgi T00870 USF y factor. hamster s ?T00870 NULL http://local gamma- host/cgi- factor, bin/biobas USF, e/transfac/ upstream chick, 7.4/bin/get stimulator Gallus vertebrate TFProf.cgi T00872 USF y factor. gallus s ?T00872 NULL http://local eUSF, host/cgi- may USF, bin/biobas anchor USF1, e/transfac/ TFIID to upstream duck, 7.4/bin/get a TATA- stimulator Cairina vertebrate TFProf.cgi less T00876 USF y factor. moschata s ?T00876 promoter NULL http://local MLTF, host/cgi- USF, bin/biobas USF1, rat, e/transfac/ upstream Rattus 7.4/bin/get stimulator norvegicu vertebrate TFProf.cgi T00875 USF-1 y factor. s s ?T00875 NULL transcripti onal activator (together with Mitf eUSF <T01554> (duck), ) of the T- MLTF, box pf51, http://local transcripti UEF, host/cgi- on factor USF, bin/biobas Tbx2 USF1, e/transfac/ <T04358> upstream mouse, 7.4/bin/get in stimulator Mus vertebrate TFProf.cgi melonocyt T00877 USF-1 y factor. musculus s ?T00877 es [1] NULL immunolo transcripti gically onal unrelated activator with [10] [11] USF44 [13] [17] [24] cooperativ [13] e bends interaction DNA with TFII- towards I [14] and the minor TFIID groove by [25] may 74-82 have to deg [7] direct DNA- stable binding is preinitiatio sensitive n to CpG complex methylatio formation n [23] the during eUSF basic chromoso (duck), region me MLTF, contacts assembly MRF DNA [16] is (yeast), within the stimulated pf51, major by UEF, http://local groove, C/EBPalp USF, host/cgi- thereby ha to USF43, bin/biobas adopting transactiv USF1, e/transfac/ alpha- ate the upstream human, 7.4/bin/get helical human stimulator Homo vertebrate TFProf.cgi conformati C/EBPalp T00874 USF1 y factor. sapiens s ?T00874 on [3] ha gene ubiquitous represses Sp1- mediated transactiv ation through uteroglobi n given promoter sequence element II is N- [1] terminally suppressi truncated on of Tat- [3] 6 mediated potential transactiv N- ation [2] glycosylati represses on sites basal (N-X-S/T) expressio [3] n of HIV http://local homology promoter host/cgi- to factors [2] not bin/biobas Sp1 able to e/transfac/ <T00759> cooperate human, 7.4/bin/get and SP4 with NF- SPR-2, Homo vertebrate TFProf.cgi <T02339> kappaB ubiquitous T02338 Sp3 SP-3. sapiens s ?T02338 [3] [2] [2] http://local host/cgi- bin/biobas e/transfac/ chick, 7.4/bin/get SPR-2, Gallus vertebrate TFProf.cgi T02419 Sp3 SP-3. gallus s ?T02419 NULL http://local host/cgi- involved bin/biobas in rat, e/transfac/ mediating (adult:) Rattus 7.4/bin/get ethanol- lung norvegicu vertebrate TFProf.cgi induced epithelial T02453 Sp3 s s ?T02453 stress [1] cell line [2] binds to initiator regions (Inr), cooperate s with USF interaction with Phox1 and SRF in vitro and in vivo [1] promotes the formation TFII-I, of Phox1- SPIN, http://local dependent General host/cgi- signal Transcripti bin/biobas responsiv on Factor e/transfac/ e II-I, human, 7.4/bin/get complexe GTF2I, Homo vertebrate TFProf.cgi s on the T00824 TFII-I BAP-135. sapiens s ?T00824 SRE [1] NULL involved in in skeletal myogenes and heart is [6] muscle cooperate cells, s with MEF-2 myogenic recognize bHLH s the factors [6] same induces sequence MyoD [6] motif [3] induced MEF-2 in by brain myogenin binds to [8] an cooperate extended s with sequence, MyoD possible through due to direct interaction interaction with s and by additional binding to factors [3] either gene MEF-2 expressio sites or to http://local n in E-box host/cgi- developin elements bin/biobas g brain [4] myogenic e/transfac/ see for expressio cells, mouse, 7.4/bin/get detailed n in brain [7]; MEF-2, Mus vertebrate TFProf.cgi informatio cerebellu developin T00505 MEF-2 MEF-2A. musculus s ?T00505 n [5] m: begins g brain [5] (embryo 8.5 days:) tail bud, caudal activator neural of plate/tube intestine- and specific notochord promoters , (embryo [7] [2] 12.5 d.) may be gut redox- endoderm regulated , caudal [7] tip of regulatate neural s both tube, proliferatio (embryo n and >15 d.) differentiat intestinal ion in epithelial intestinal cells epithelial (duodenu cells [5] m, CBP is a jejunum, http://local coactivato ileum, host/cgi- r cecum, CDX2, bin/biobas interacting colon), caudal e/transfac/ with the cell lines homolog mouse, 7.4/bin/get dimeric homeo (STC-1, homeobox Mus vertebrate TFProf.cgi DNA- domain of GLUTag) T02002 Cdx-2 protein 2. musculus s ?T02002 binding [7] Cdx-2 [1] [7] [2] activator of the insulin and glucagon gene [3] [2] probably involved in the post- weaning decline of lactase- phlorizin hydrolase (LPH) causing lactose intoleranc e [1] Cdx- 2/3 similar mediates DNA- activation binding of the intestine, specificity proglucag pancreas http://local as Lmx-1 on islets, low golden host/cgi- [3] Cdx-3 promoter levels in (Syrian) bin/biobas is the in both testis [3]; hamster, e/transfac/ hamster islet and cell lines Mesocrice 7.4/bin/get homologu enteroend (INR1-G9 Cdx-2, tus vertebrate TFProf.cgi e of Cdx- ocrine and HIT T02003 Cdx-3 shCdx-2. auratus s ?T02003 2 [2] [1] cells [2] cells) [2] the Clox homolog is a splice variant [5] the 3 cut repeats also contribute to DNA- binding, each individual repeat and each combinati on exhibiting repressor slightly [13] [12] CDP, different [9] [8] [6] CCAAT DNA- [3] may displacem binding regulate ent specificity S/MAR- protein, [4] [2] [5] binding cut CR1 factor homeodo exhibits SATB1 main the most and may protein, http://local restricted be Cux, cut- host/cgi- resognitio regulated like bin/biobas n pattern by it via homeodo e/transfac/ [4] KD protein- main human, 7.4/bin/get (CR3- protein protein, Homo vertebrate TFProf.cgi homeo interaction T00100 CUTL1 Clox. sapiens s ?T00100 domain) [1] NULL AREB6 is the extended form of Nil-2-a [4] Nil-2-a was originally reported repressor to be a of protein of interleukin 735 AA -2 with an expressio expected n [6] molecular repressor Nil-2-a, weight of of the TCF8 80.5 kDa immunogl (gene containing obulin name), 3 zinc heavy- AREB6, finger chain Atp1a1 motifs enhancer Regulator zinc [3] y Element finger 4 is transcripti Binding of C2HC- onal protein 6, type, repression ZEB, zinc while the might be finger E- http://local others mediated box- host/cgi- are of by the binding bin/biobas C2H2- negative protein, e/transfac/ type [4] cofactor T cells; negative human, 7.4/bin/get S/T-rich NC2 heart [4]; regulator Homo vertebrate TFProf.cgi region <T00197> skeletal T00625 AREB6 of IL2. sapiens s ?T00625 between [1] muscle [4] spectrosc transcripti opic data: onal CD [15] activator [14], EPR [36] of [15] muscle- crystal specific structure genes [5] [43] heterodim myogenic ers with master E12/E47 gene bind product more causing avidly to myogenic DNA than differentiat homodime ion [48] rs [37] [47] [41] [25] [26] inhibitor the of cell heterodim proliferatio er is n identical depending to the on the DNA- HLH binding domain activity [34] [35] http://local MEF-1 can partly proliferatin host/cgi- [26] A114 substitute g MEF1, bin/biobas is for Myf-5 myoblasts Myf-3 e/transfac/ essential and vice and (human), mouse, 7.4/bin/get for DNA- versa [23] differentiat MyoD, Mus vertebrate TFProf.cgi binding, induced ed T00526 MyoD MyoD1. musculus s ?T00526 T115 for immediate myotubes 38% transcripti amino onal acid repressor identity to [3] may Bach1 play an <T04793> important [3] role in contains coordinati a BTB ng (broad transcripti complex- onal tramtrack- activation bric-a- and/or brac) repression domain by MafK which is a <T01435> protein [3] acts interaction synergistic motif [3] ally with binds MafK as both as repressor dimer of the IgH (cell with MafK 3 lines:) <T01435> enhancer M1, and as [2] NIH3T3, monomer probably C1300, http://local to DNA plays a B220+, host/cgi- [3] Bach2 role B31-1, 63- bin/biobas consensu during B- 12, 18- BTB and e/transfac/ s binding cell 81, CNC mouse, 7.4/bin/get site is maturatio NFS5.2, homolog Mus vertebrate TFProf.cgi nearly n [2] 38B9 [3] T04792 Bach2 2. musculus s ?T04792 identical synergistic [2] [1] http://local host/cgi- bin/biobas BTB and e/transfac/ CNC human, 7.4/bin/get homolog Homo vertebrate TFProf.cgi T04795 Bach2 2. sapiens s ?T04795 NULL size of the gag- maf fusion protein: 864 AA, 95 kDa (gene), 100 kDa (SDS), with some variation among different clones [6] binds to TRE-type and CRE- type elements (MAREs, Maf recognitio n elements) AS42, http://local with transcripti avian host/cgi- equal onal musculoa bin/biobas affinity [1] activator poneurotic e/transfac/ DNA- [3] with 7.4/bin/get binding transformi fibrosarco vertebrate TFProf.cgi specificity ng activity T01430 v-Maf ma virus s ?T01430 is similar [5] NULL dimeric activator DNA- and binding repressor [35] co- binding to crystals serum of DNA- response binding elements domain (SRE) (132-223) and and DNA cooperatin (SRE): g with two p62TCF, antiparalle Elk-1 [35] l [8] amphipath antagonist ic alpha- ic to YY1 (HeLa); helices by chicken (alpha-I), binding embryo arranged competitio protein as coiled n [25] (Immunop coil, YY1 eroxidase approxima binding to staining): CArG- tely the HH stage- binding parallel serum 12: factor, on the response abundant CBF (3) minor element in (mouse), http://local groove of (SRE) is myocardiu p67, host/cgi- the A/T- essential m and p67SRF, bin/biobas rich to myotomal SRF, e/transfac/ center enhance portion of serum human, 7.4/bin/get [13] SRF anterior response Homo vertebrate TFProf.cgi helices binding somites T00764 SRF factor. sapiens s ?T00764 make [15] [10] in vitro and in vivo http://local phosphory host/cgi- lation by bin/biobas casein rat, e/transfac/ kinase II, Rattus 7.4/bin/get leading to norvegicu vertebrate TFProf.cgi phosphory induction T00766 SRF SRF. s s ?T00766 lation of c-fos NULL different splice variants http://local <T00765> host/cgi- , bin/biobas <T03995> e/transfac/ , serum mouse, 7.4/bin/get <T03996> response Mus vertebrate TFProf.cgi , T05114 SRF factor. musculus s ?T05114 <T03997> NULL full length cDNA clone is <T00765> exons 3, 4 and 5 are missing [1] in alternative splice variant <T03995> exon 5 is http://local missing, host/cgi- in bin/biobas <T03996> e/transfac/ exons 4 mouse, 7.4/bin/get and 5 are embryo: SRF (263 Mus vertebrate TFProf.cgi missing E10, E13 T03997 AA) SRF-I. musculus s ?T03997 [1]. [1] full length cDNA clone is <T00765> exons 4 and 5 are missing [1] in alternative splice variant <T03995> exon 5 is missing, http://local in host/cgi- <T03997> bin/biobas exons 3, e/transfac/ 4 and 5 mouse, 7.4/bin/get are SRF (400 Mus vertebrate TFProf.cgi missing adult: T03996 AA) SRF-S. musculus s ?T03996 [1]. aorta [1] full length cDNA clone is Embryo:E <T00765> inhibition 9,E10,E13 exon 5 is of SRE- ,E14 missing dependent [1];adult: [1] in promoter testis,liver, alternative activity of kidney,lun splice cardiac g,uterus,a variant alpha- orta, <T03996> actin heart,skel exons 4 promoter, etal and 5 are skeletal muscle missing, alpha- [1]; brain, in actin heart [2]; <T03997> promoter, C2C12 exons 3, SM22 un- and 4 and 5 alpha differentiat are promoter ed missing and myoblasts [1] smooth , binding alpha myotubes DNA as actin [1]; rat homodime promoter VSMC http://local r [2] [2] [1]; host/cgi- heterodim repression protein bin/biobas erization of serum- level: P19 e/transfac/ with C- induced cells, mouse, 7.4/bin/get terminal activity of C2C12 SRF (440 Mus vertebrate TFProf.cgi truncated c-fos- myoblasts T03995 AA) SRF-M. musculus s ?T03995 SRF [2] SRE [2] [1] binds to serum response element (SRE) rapid and Embryo: transient E9,10,13, induction 14 of SRF [1];adult: mRNA testis,liver, synthesis kidney,lun after g,uterus,a serum orta [1]; stimulatio heart,sk n (60-480 muscle min, [1] [4]; somewhat kidney,spl delayed een,stoma compared ch [2]; with c- C2C12 fos un-, mRNA: differentiat CArG- possible ed binding hint on myoblasts factor, SRF role ,myotubes CBF (3), in shutoff [1];rat p67, http://local of c-fos VSMC p67SRF, host/cgi- transcripti [1];protein: SRF, bin/biobas on) [6] serum e/transfac/ progressiv P19,C2C1 response mouse, 7.4/bin/get e 2 SRF (504 factor, Mus vertebrate TFProf.cgi phosphory myoblasts T00765 AA) SRF-L. musculus s ?T00765 lation [1] activator [7] involved in control (embryo of 8.5 days:) embryoge ventrome nesis [6] dial part oncogenic of potential, somites, depending (embryo on an 9.5-10-5 intact days:) paired sclerotom domain e cells, [6] (embryo mutations 12.5 cause days:) Undulated invertebral discs phenotype anlagen [5]; (alteration (embryo s in the 14.5 vertebral days:) column, perichord sternum, al zone http://local scapula, [9] [5]; HuP48 host/cgi- facial (newborn: (human), bin/biobas no skeleton ) ventral Pax-1, e/transfac/ homeo an part of PAX1, mouse, 7.4/bin/get domain thymus), annulus mPax-1, Mus vertebrate TFProf.cgi pI(calc) = e. g. fibrosus T00677 Pax-1 mPax1. musculus s ?T00677 10.1. G18S [5] active during comprises mesencha a my-to remnant epithelium of a transition homeo in early domain kidney similar developm sequence ent [6] specificity overexpre as Pax-6 ssed in [3] as in Wilms murine tumor [6] http://local cells, tumor host/cgi- there may initiation bin/biobas be two by e/transfac/ human inhibiting PAX2, human, 7.4/bin/get splice the p53 hPax2, Homo vertebrate TFProf.cgi variants transcripti T01823 Pax-2 hPax-2. sapiens s ?T01823 as well [6] on [2] NULL active during mesenchy me-to- epithelium transition in early kidney developm ent [4] overexpre sed in Wilms tumor [4] oncogenic potential [3] Pax-2, Pax-5 and Pax- 8 show overlappin g expressio condensin a splice n with the g variant is engrailed mesenchy Pax-2b genes me cells http://local [4] Pax-2 and bind & their host/cgi- comprises as epithelial bin/biobas a activators derivative Pax-2, e/transfac/ remnant to the En- s in the PAX2, mouse, 7.4/bin/get of a 25 developin mPax2, Mus vertebrate TFProf.cgi homeo enhancer g kidney T00678 Pax-2a mPax-2. musculus s ?T00678 domain [1] [4] independe activator nt DNA- (fused to binding GAL4- by paired DNA 8.5-d and binding embryos: homeo domain) mitotic domain [14] cells in contacting mutations the ATTA may ventricular and cause zone of GTTCC Splotch developin motifs, (pigmenta g spinal resp. [12] tion chord; variable abnormalit some spacing ies in iris regions in of the and hair, hindbrain, subsites eye midbrain, [13] displacem diencepha paired ent, lon; 10- domain exenceph 12-d induces aly, spina embryos: conformati bifida, neural onal lack of crest of change in limb developin the DNA musculatu g spinal [12] re) [21] ganglia, http://local homodime [19], e. g. cranofacia host/cgi- rization G42R l HuP2 bin/biobas upon [12] or mesectod (human), e/transfac/ DNA- point erm, limb PAX3, mouse, 7.4/bin/get binding mutation mesenchy mPax-3, Mus vertebrate TFProf.cgi through causing me (10- T00680 Pax-3 mPax3. musculus s ?T00680 residues aberrant 11 d) [20] Pax-4 homozygo gene us presumabl knockout y exists mice die as a after birth single within 3 copy in days the showing MIN6, genome growth betaTC [3] the retardatio and NIT- activation n and 1 cells domain dehydratio [3]; seems to n (embryo be E1A- (apparentl 9.5 days:) responsiv y as a ventral e conseque spinal whereas nce of cord, the insulin pancreas, repression deficiency (embryo domain ) [5] 10.5 is general differentiat days:) active [1] ion of dorsal three endocrine pancreas, splice progenitor (embryo variants s to beta 11.0 found and delta days:) http://local which cells [5] ventral host/cgi- were not Pax-4 pancres, bin/biobas named by binds to (newborn: PAX4, e/transfac/ the islet ) insulin- mPAX4, mouse, 7.4/bin/get authors hormone producing Pax-4, Mus vertebrate TFProf.cgi [4] the C- promoters beta cells T02983 Pax-4a mPax-4. musculus s ?T02983 terminal [5] repressor of human insulin promoter by 93 and binding 91.7% the C2 identity element with [1] murine inhibitory http://local Pax-4 activity on host/cgi- nucleotide islet bin/biobas and amyloid RIN (rat rat, e/transfac/ amino polypeptid insulinom Rattus 7.4/bin/get acid e (IAPP) a) cells, PAX4, norvegicu vertebrate TFProf.cgi sequence promoter pancreatic T03001 Pax-4a Pax-4. s s ?T03001 [2] [1] islets [2] repressor of human insulin promoter by binding the C2 element [1] inhibitory http://local activity on host/cgi- islet bin/biobas amyloid RIN (rat rat, e/transfac/ polypeptid insulinom Rattus 7.4/bin/get e (IAPP) a) cells, PAX4, norvegicu vertebrate TFProf.cgi promoter pancreatic T03003 Pax-4c Pax-4. s s ?T03003 [1] islets [2] intact paired domain required for recognitio n of all Pax-5 binding regulator sites [2] a of B cell BSAP, C- developm Pax-5, B- terminally ent [3] cell http://local truncated tumor specific host/cgi- paired initiation activator bin/biobas domain by (pro-, pre- protein, e/transfac/ recognize inhibiting , mature PAX5, human, 7.4/bin/get sa the p53 B cells), hPax5, Homo vertebrate TFProf.cgi subset of transcripti astrocytic T00070 Pax-5 hPax-5. sapiens s ?T00070 sites [2] on [1] tumors [1] required for B-cell developm ent [5] represses Ig 3 alpha enhancer by preventing binding of an activator [3] also required for correct early a few developm difference ent of s within posterior the paired midbrain domains [5] determine expressio different n BSAP, DNA- positively Pax-5, B- binding regulated cell http://local sequence by E2A specific host/cgi- specificitie genes [4] activator bin/biobas s Pax-2, protein, e/transfac/ between Pax-5 PAX5, mouse, 7.4/bin/get Pax-5 and Pax- (pro-, pre- mPax5, Mus vertebrate TFProf.cgi and Pax- 8 show , mature T01201 Pax-5 mPax-5. musculus s ?T01201 6 [2] overlappin B cells) heterozyg ous (embryo mutations 8 days:) cause surface- small eye and (Sey) and neuroecto die a few derm minutes [10]; after birth (embryo [13] [8] 8.5 days:) essential forebrain role in the and developm spinal ent and cord [15]; function (embryo of 9.0:) glucagon- telenceph producing alon, cells in diencepha both lon, pancreatic neural and tube, the intestinal optic expressio endoderm vesicle, n of Pax- al pancreas 6 and lineages [8]; Pax-6, http://local Vax-1 is [3] lens- (adult:) Sey, host/cgi- compleme specific lens, PAX6, bin/biobas ntary and expressio brain, Small e/transfac/ exclusive n of zeta- pancreas eye, mouse, 7.4/bin/get in the crystallin endocrine mPax-6, Mus vertebrate TFProf.cgi forebrain [11] eye cells [11] T00681 Pax-6 mPax6. musculus s ?T00681 [6] and nasal [8] Pax-8 contains a remnant Pax-2, of a Pax-5 homeo and Pax- domain 8 show there may overlappin be many g splice expressio variants n with the [2] Kr of engrailed Pax-8 to genes http://local the BS-I and bind host/cgi- and BS-II as bin/biobas site is activators e/transfac/ 3.33 Exp to the En- PAX8, mouse, 7.4/bin/get 5 and 25 mPax-8, Mus vertebrate TFProf.cgi 0.32 Exp enhancer T01828 Pax-8 mPax8. musculus s ?T01828 5 [1] [1] NULL binds in a mutually exclusive manner with TTF- 1 to some thyroid- specific promoters [3] activates preferenti ally http://local thyroid fetal: host/cgi- peroxydas thyroid bin/biobas there may e (TPO) [1]; adult: rat, e/transfac/ be many and kidney, Rattus 7.4/bin/get splice thyroperox thyroid norvegicu vertebrate TFProf.cgi variants ydase [3]; TL5 T01829 Pax-8 PAX8. s s ?T01829 [2] (Tg) [3] [1] cell line [3] there are many splice variants (Pax-8a to 8f) four http://local of themtumor host/cgi- (Pax-8ainitiation bin/biobas to -8d)by e/transfac/ being inhibiting PAX8, human, 7.4/bin/get cloned the p53 hPax-8, Homo vertebrate TFProf.cgi transcripti from man T02898 Pax-8 hPax8. sapiens s ?T02898 [2] on [1] TCF-1P NULL regulation might be regulated by APC and beta- catenin [1] due to the presence most of the similar to Groucho human interacting splice domain variant this TCF-1B isoform except a can act 31 AA as a insert negative after regulator residue of Wnt 88 of the signalling human pathway factor [1] for most expressio abundant n in teeth, http://local isoform see [2] T cell host/cgi- lacking cell factor 1, bin/biobas an beta- specifity: TCF-1, e/transfac/ catenin T cells [5] TCF-1P, mouse, 7.4/bin/get interacting nucleus see TCF-7, Mus vertebrate TFProf.cgi domain of functional T01109 TCF-1(P) TCF7. musculus s ?T01109 [1] intestine features tripartite activator DNA- [24] [17] binding may act domain synergistic comprisin ally when g the bound to POUs two homology distant region sites [17] extended involved towards in the N- hepatocyt terminus e-specific (pos. gene 113), the expressio homeo n, domain, although and the not being dimerizati the sole on determina domain nt [18] [21] [12] dimerizati cooperate on s with domain other liver- comprises enriched http://local a kinked factors host/cgi- alpha such as liver, APF, bin/biobas helix (7- C/EBP, intestine, HNF1, rat, e/transfac/ 18 and HNF-3, spleen, HNF- Rattus 7.4/bin/get 23-32), HNF-4 stomach, 1alpha, norvegicu vertebrate TFProf.cgi both [12] kidney T00369 HNF-1 LF-B1. s s ?T00369 helices in expressed [18] http://local host/cgi- bin/biobas e/transfac/ chick, 7.4/bin/get Gallus vertebrate TFProf.cgi T01952 HNF-1 gallus s ?T01952 NULL usage of an alternative poly(A) signal leads to activator HNF-1B, [5] whereas synergistic an unspliced interaction intron with APF, introduces C/EBPalp liver, HNF1, http://local a new ha [1] intestine, HNF- host/cgi- stop activator spleen, 1alpha, bin/biobas codon of some stomach, LF-B1, e/transfac/ giving intestine- kidney; TCF-1, human, 7.4/bin/get rise to specific cell lines HNF-1A, Homo vertebrate TFProf.cgi HNF-1C promoters (Caco T00368 HNF-1A HNF-1. sapiens s ?T00368 [5] [2] [3] cells) [2] factor formerly designate http://local d as LF- host/cgi- B1 and bin/biobas suppleme e/transfac/ ntary domestic 7.4/bin/get identified pig, Sus vertebrate TFProf.cgi as HNF- activator T01180 HNF-1A LF-B1. scrofa s ?T01180 1A [2] [1] [1] NULL glycosylati on similar factor in lung: 110 + 120 kDa (SDS) dimerizes in the absence of DNA [5] unusual for homeobox genes, gene http://local regions induced APF, host/cgi- encoding in F9 HNF1, bin/biobas helix 2 cells by liver, HNF- e/transfac/ and 3 are RA, intestine, 1alpha, mouse, 7.4/bin/get separated plateau spleen, LF-B1, Mus vertebrate TFProf.cgi by an after 5d stomach, T01211 HNF-1A HNF-1A. musculus s ?T01211 intron [2] [4] kidney activator, may modulate the activity of HNF-1 [1] predomin antly found in dedifferen tiated hepatoma cells [6] expressed in several endoderm HNF- http://local al and 1beta, LF- host/cgi- mesoder B3 bin/biobas mal (mouse), rat, e/transfac/ embryonal TCF-2, Rattus 7.4/bin/get tissues vHNF-1, norvegicu vertebrate TFProf.cgi before T00889 HNF-1B vHNF1. s s ?T00889 HNF-1 [5] NULL kidney, lung, (liver, ovary, intestine, stomach: induced weak http://local in F9 mRNA- host/cgi- cells by signal), LF-B3, bin/biobas retinoic epithel of TCF-2, e/transfac/ acid, endo- vHNF-1, mouse, 7.4/bin/get max. and LFB3, Mus vertebrate TFProf.cgi after 24 mesoder T00890 HNF-1B vHNF1. musculus s ?T00890 hours [3] mal origin usage of an alternative poly(A) signal leads to HNF-1A, whereas an unspliced intron introduces http://local a new host/cgi- stop activator, bin/biobas codon 5-fold e/transfac/ giving more human, 7.4/bin/get rise to potent cell lines HNF- Homo vertebrate TFProf.cgi HNF-1C than HNF- (Caco T01950 HNF-1B 1beta. sapiens s ?T01950 [3] 1A [3] cells) [1] activator, 5-fold more potent than HNF- 1A [2] mRNA levels are about 4- 11% of HMF-1A usage of mRNA http://local an ecept host/cgi- alternative fetal and bin/biobas poly(A) adult e/transfac/ signal kidney human, 7.4/bin/get leads to (86% and Homo vertebrate TFProf.cgi HNF-1A 27%, T01951 HNF-1C sapiens s ?T01951 [2] resp.) [2] NULL http://local host/cgi- LF-B3, bin/biobas vHNF-1, e/transfac/ LFB3, domestic 7.4/bin/get vHNF-1A, pig, Sus vertebrate TFProf.cgi T01955 vHNF-1 vHNF1. scrofa s ?T01955 NULL splice variant vHNF-1B exhibits an internal deletion, variant activator, vHNF-1C higher lacks the activity C- and http://local terminal higher host/cgi- part due DNA- bin/biobas to usage binding HNF- e/transfac/ of affinity 1beta, human, 7.4/bin/get another than vHNF-1, Homo vertebrate TFProf.cgi poly(A) vHNF-1B T00891 vHNF-1A vHNF-1A. sapiens s ?T00891 signal [1] [2] liver, lung splice variant vHNF-1A exhibits an insertion after position 182, variant activator, vHNF-1C lower lacks the activity C- and http://local terminal higher host/cgi- part due DNA- bin/biobas to usage binding e/transfac/ of affinity human, 7.4/bin/get another than Homo vertebrate TFProf.cgi poly(A) vHNF-1A T01953 vHNF-1B sapiens s ?T01953 signal [1] [2] liver, lung transdomi nant repressor, relative level compared with splice variant A variant varies in vHNF-1B different exhibits tissues an between internal 4.7% and deletion, 43.5%, variant the vHNF-1A highest has an relative extended concentrat C- ions http://local terminal found in host/cgi- part due fetal and bin/biobas to usage adult e/transfac/ of kidney human, 7.4/bin/get another (43.5 and Homo vertebrate TFProf.cgi poly(A) 40%, T01954 vHNF-1C sapiens s ?T01954 signal [1] resp.) [1] liver, lung binds to DNA as a homotetra mer, in solution is primarily a dimer [3] belongs to the Granyhea d-like family of TFs, activator together activates with transcripti Drosophil on of a Elf- SV40 late 1/NTF-1 promoter factors, [11] and likely genetic presents determina novel nt of type of Alzheimer alpha- DNA s disease CP2a, binding [2] CP-2, http://local [3] biallelic LSF, host/cgi- recognize polymorph alpha- bin/biobas s DNA ism, A- CP2, LBP- e/transfac/ elements >G, 1c, Late human, 7.4/bin/get consisting influences SV40 Homo vertebrate TFProf.cgi of two the risk T00151 CP2 factor. sapiens s ?T00151 directly of AD [2]. NULL http://local host/cgi- adult bin/biobas thymus, growth rat, e/transfac/ splenocyt factor Rattus 7.4/bin/get es, independe norvegicu vertebrate TFProf.cgi repressor spleen, T01921 Gfi-1 nce 1. s s ?T01921 [2] testis [2] alternative transcripti splice onal variants activator [7] the in the pol bipartite II [64] and DNA- in the pol binding III system (POU) [57] also domain part of comprises the a POU- replication specific (POUs) machinery and a of POU adenoviru homeo s [71] for (POUh) stimulatio domain n of [67] the replication (Ig)NF-A, homeo , the DNA- alpha-H1, domain binding NF-A1, contains domain NF-III, a (whole OBP100, recogniza POU Oct-1, ble helix- domain) octamer- turn-helix is binding http://local motif [63] required factor, host/cgi- [67] [4] (POUs is oct-B1A, bin/biobas the POU- inert, oct-B1B, e/transfac/ specific POUh OTF-1, human, 7.4/bin/get domain inhibitory) TRF, Oct- Homo vertebrate TFProf.cgi comprises and ubiquitous T00641 POU2F1 1B. sapiens s ?T00641 4 alpha- sufficient [63] (Ig)NF-A, alpha-H1, NF-A1, NF-III, OBP100, Oct-1, octamer- http://local binding host/cgi- factor, bin/biobas oct-B1A, clawed e/transfac/ oct-B1B, frog, 7.4/bin/get OTF-1, Xenopus vertebrate TFProf.cgi T00642 POU2F1 TRF. laevis s ?T00642 (kidney) http://local host/cgi- differential bin/biobas rat, e/transfac/ phosphory Rattus 7.4/bin/get lation norvegicu vertebrate TFProf.cgi phosphory during T00643 POU2F1 Oct-1. s s ?T00643 lation cell cycle NULL alpha-H1, IgNF-A, NF-A, NF- A1, NF- III, OBP100, Oct-1, octamer- http://local binding host/cgi- factor, bin/biobas oct-B1A, monkey, e/transfac/ oct-B1B, Cercopith 7.4/bin/get OTF-1, ecus vertebrate TFProf.cgi T00959 POU2F1 TRF. aethiops s ?T00959 ubiquitous alpha-H1, IgNF-A, NF-A, NF- A1, NF- III, OBP100, Oct-1, octamer- http://local binding host/cgi- factor, bin/biobas oct-B1A, e/transfac/ oct-B1B, chick, 7.4/bin/get OTF-1, Gallus vertebrate TFProf.cgi T01031 POU2F1 TRF. gallus s ?T01031 NULL http://local host/cgi- bin/biobas gibbon e/transfac/ ape, 7.4/bin/get Oct-1, Hylobates vertebrate TFProf.cgi T01157 POU2F1 OTF-1. lar s ?T01157 NULL DNA- binding is reduced by GR in a ligand- dependent manner interaction with HSV VP16 http://local directs host/cgi- Oct-1 bin/biobas homeo preferably e/transfac/ domain to the hamster, 7.4/bin/get essential TAATGA Cricetulus vertebrate TFProf.cgi for GR RAT T01466 POU2F1 griseus s ?T01466 at least 3 motif [2] NULL interaction splice variants are encoded by the murine oct-1 gene [2] compared to the human homolog, mouse Oct-1 exhibits four AA exchange s within alpha-H1, helix 1 IgNF-A, and 2 NF-A, NF- making A1, NF- its III, sequence OBP100, more Oct-1, similar to DNA- octamer- http://local (human) binding is binding host/cgi- Oct-2 and reduced factor, bin/biobas thus by GR in oct-B1A, e/transfac/ causing a a ligand- oct-B1B, mouse, 7.4/bin/get much dependent OTF-1, Mus vertebrate TFProf.cgi weaker manner ubiquitous T00644 POU2F1a TRF. musculus s ?T00644 interaction [4] [9] conflict Evi-1 between antagoniz EMBL es in entry TGF-beta #AB00493 signaling 0 and by EMBL quenching entry Smad-3 #U68019, [11] the in which first zinc an aa- finger sequence domain of 425 Evi-1 is AAs in essential lenghth is for the described interaction based on with RNA in Smad-3, contrast whereas to the one the MH2 based on domain of DNA in Smad-3 EMBL is #AB00493 essential 0 from for the AA 178 interaction http://local an with Evi- host/cgi- insertion 1 [11] it is bin/biobas of 10 AAs indicated e/transfac/ (VGTWA that Evi-1 human, 7.4/bin/get AQAGL) abrogates Homo vertebrate TFProf.cgi is the T04096 SMAD-3 sapiens s ?T04096 described interaction NULL http://local host/cgi- bin/biobas zebra e/transfac/ fish, 7.4/bin/get Brachyda vertebrate TFProf.cgi T04149 SMAD-3 nio rerio s ?T04149 NULL -/- mice are smaller than wild- type littermates [4] [5] some have an incomplet ely penetrant forepaw defect, (embryo): torqued throughou hind t limbs, embryonic kyphosis or display developm marked ent [4]; rib cage (adult): malformati bone on and marrow, die heart, between brain, 1 and 8 kidney http://local months [4]; lung, host/cgi- [5] death spleen, bin/biobas of -/- thymus e/transfac/ mice [4] [5]; mouse, 7.4/bin/get between pituitary Mus vertebrate TFProf.cgi 1 and 8 gonadotro T04210 SMAD-3 musculus s ?T04210 months pes [1] http://local host/cgi- bin/biobas e/transfac/ chick, 7.4/bin/get partial Gallus vertebrate TFProf.cgi cDNA T04248 SMAD-3 gallus s ?T04248 sequence NULL http://local host/cgi- bin/biobas e/transfac/ domestic 7.4/bin/get pig, Sus vertebrate TFProf.cgi T04251 SMAD-3 scrofa s ?T04251 NULL C- terminal region (MH2 domain) and conserved glycin residue (AA 379) in L3 loop, which is proposed to be involved in protein- protein interaction , are required for the self- stimulator y activtity [2] MH1 http://local domain host/cgi- and four bin/biobas lysin rat, e/transfac/ residues Rattus 7.4/bin/get at norvegicu vertebrate TFProf.cgi positions T04431 SMAD-3 s s ?T04431 40, 41, 43 NULL the C- terminal expressed zinc at time finger and place plus the of heart adjacent developm basic ent [2] domain required (251-324) for are cardiac necessary muscle- and specific sufficient gene for DNA- expressio binding n in [4] the DMSO- region treated around P19 cells the C- [5] terminal ectopic zinc expressio finger n can (251-324) rescue also erythroid contains differentiat a nuclear ion of http://local localizatio GATA-1 host/cgi- n signal <T00305> bin/biobas [4] N- and deficient e/transfac/ C- murine mouse, 7.4/bin/get terminal embryonic Mus vertebrate TFProf.cgi sequence stem T02532 GATA-4 musculus s ?T02532 s are cells [6] NULL adult: (highest:) heart, (lower:) http://local ovary and host/cgi- small bin/biobas transcribe intestine e/transfac/ d during [2]; chick, 7.4/bin/get heart embryonic Gallus vertebrate TFProf.cgi developm : (mainly:) T02682 GATA-4 gallus s ?T02682 ent [2] heart [2] http://local host/cgi- bin/biobas e/transfac/ human, 7.4/bin/get (Caco-2 Homo vertebrate TFProf.cgi <0239> T02687 GATA-4 sapiens s ?T02687 [3]) http://local host/cgi- bin/biobas clawed e/transfac/ frog, 7.4/bin/get Xenopus vertebrate TFProf.cgi T02711 GATA-4 laevis s ?T02711 NULL up- regulated in cardiomyo cytes http://local after host/cgi- two treatment heart bin/biobas different with (cardiomy rat, e/transfac/ sequence triidothyro ocytes), Rattus 7.4/bin/get s nine or testis, GATA- norvegicu vertebrate TFProf.cgi published retinoic ovary [1] T02716 GATA-4 GT2. s s ?T02716 [5] [1] acid [2] [3] associate d with t(11 14)(p13 q11) translocati ons in T specificall cell http://local y leukemias LIM-only host/cgi- interacts [1] protein 2, bin/biobas with Tal-1 essential RBTN2, e/transfac/ in for Rhomboti human, 7.4/bin/get erythroid erythroid n-2, TTG- Homo vertebrate TFProf.cgi cells [2] differentiat T02250 Lmo2 2. sapiens s ?T02250 [3] ion [1] NULL specificall y interacts with Tal-1 in erythroid important cells [3] for [4] erythropoi interacts esis [2] with may form GATA-1in a bridge erythroid in high http://local cells, LIM order LIM-only host/cgi- domain complex protein 2, bin/biobas may be that RBTN2, e/transfac/ responsibl comprises Rhomboti mouse, 7.4/bin/get e for this GATA-1, n-2, TTG- Mus vertebrate TFProf.cgi interaction Tal-1 and T02251 Lmo2 2. musculus s ?T02251 [2] [1] E47 [2] NULL http://local HNF- host/cgi- full length brain, 3/Fkh bin/biobas sequence heart, Homolog rat, e/transfac/ has not intestine, 2, HFH2, Rattus 7.4/bin/get been kidney, Genesis, norvegicu vertebrate TFProf.cgi identified liver, lung T02290 FOXD3 HFH-2. s s ?T02290 so far [4] [4] expressio n pattern (embryo discrepan 6.5-7.5 cy: in d.:) reference ubiquitous [2] , (8.5-9.0 expressio d.:) n was cranial only neural detected crest, in rhombom embryonic ere 4, stem roofplate, cells neuroepith whreres elium, reference (9.5 d.:) [1] cranial observed sensory complex ganglia, embryonic lens placode, expressio neural n transcripti tube, patterns onal neural in the repressor crest, neural with sympathet http://local crest fork regulatory ic gut host/cgi- head activity in ganglia, bin/biobas domain is early (10.5- e/transfac/ identical embryonic 12.5 d.:) HFH2, mouse, 7.4/bin/get to rat neural Genesis, Mus vertebrate TFProf.cgi FOXD3 differentiat crest T04166 FOXD3 HFH-2. musculus s ?T04166 <T02290> ion [2] cells [1] http://local host/cgi- bin/biobas e/transfac/ human, 7.4/bin/get Homo vertebrate TFProf.cgi T04167 FOXD3 sapiens s ?T04167 NULL CBF(2), CBF-A + CBF-B, CCAAT- binding consists factor, of three CP1, NF- http://local subunits: Y host/cgi- CBF-A (mouse), bin/biobas <T00087> NF- rat, e/transfac/ , CBF-B YA:NF- Rattus 7.4/bin/get <T00088> YB:NF- norvegicu vertebrate TFProf.cgi , CBF-C T00084 CBF(2) YC. s s ?T00084 <T01595> NULL http://local CBF-A, host/cgi- CP1-A, bin/biobas HAP3 rat, e/transfac/ (yeast), Rattus 7.4/bin/get NF-YB norvegicu vertebrate TFProf.cgi T00087 CBF-A (mouse). s s ?T00087 NULL both the Gln- and the Ser- /Thr-rich region contribute to the transcripti onal activation activator by CBF- [2], B, each contribute per se s to the modestly activation activating potential http://local [2] trans- of the CBF-B, host/cgi- activation whole CP1-B, bin/biobas activity in CBF HAP2 rat, e/transfac/ whole multimeric (yeast), Rattus 7.4/bin/get CBF factor NF-YA norvegicu vertebrate TFProf.cgi redundant complex T00088 CBF-B (mouse). s s ?T00088 [2] [2] NULL N- terminal part is enriched in charged residues C- terminal 150 AA: enriched in hydrophob ic and glutamine residues subunit of CP1/CBF [2] subcompl ex with CBF-A which is recognize d by CBF- http://local B [2] host/cgi- CCAAT- bin/biobas binding NF-YC rat, e/transfac/ complex no DNA- (mouse), Rattus 7.4/bin/get with yeast binding CP1C norvegicu vertebrate TFProf.cgi HAP2/HA by its own T01595 CBF-C (human). s s ?T01595 P3 [2] [2] ubiquitous three subunits: CP1A <T00154> , CP1B <T01804> and activator CP1C important <T02478> regulator of MHC previously class II was gene thought to transcripti be on binds composed to X-Y- of seven boxes polypeptid cooperativ es of ely with three the RFX groups complex observed: <T05444> alpha (35 , kDa), stabilizes beta (28, binding of 27 kDa), the RFX, alpha- gamma activates CP1, http://local (33, 34, transcripti CBF, host/cgi- 37, 38 on CP1, NF- bin/biobas kDa) synergistic Y, trimer e/transfac/ stable ally with NF-Y, NF- human, 7.4/bin/get alpha:beta the RFX Y Homo vertebrate TFProf.cgi complex T00150 CP1 complex. sapiens s ?T00150 associatio [1]. NULL http://local chinese host/cgi- hamster, bin/biobas Cricetulus e/transfac/ 7.4/bin/get CP1, NF- longicaud vertebrate TFProf.cgi T01171 CP1 Y. atus s ?T01171 NULL as a subunit of the NF-Y complex, interacts directly with CIITA <T05450> subunit of [2] a trimeric interacts DNA directly binding with http://local complex RFX5 CBF-A host/cgi- NF- subunit (rat), CP1- bin/biobas YA:NF- <T01672> A, HAP3 e/transfac/ YB:NF- of the (yeast), human, 7.4/bin/get YC, see RFX NF-YB Homo vertebrate TFProf.cgi <T00150> complex T00154 CP1A (mouse). sapiens s ?T00154 . [1]. (HeLa) as a subunit of the NF-Y complex, interacts directly with CIITA <T05450> [2] interacts directly subunit of with two a trimeric subunits DNA of the binding RFX http://local complex complex, host/cgi- NF- RFX5 CBF-C bin/biobas YA:NF- <T01672> (rat), NF- e/transfac/ YB:NF- and YC human, 7.4/bin/get YC, see RFXANK (mouse), Homo vertebrate TFProf.cgi <T00150> <T05441> T02478 CP1C HSM-1. sapiens s ?T02478 . [1]. ubiquitous consists of 3 subunits: NF-YA <T00615> , NF-YB <T00616> , and NF- YC <T02477> previously was thought to be composed of seven polypeptid alpha- es of CP1, three CBF(2), groups CCAAT- observed: binding alpha (35 factor, kDa), CP1, CP1 beta (28, (human, 27 kDa), rat), NF- http://local gamma Y, NF-YA host/cgi- (33, 34, + NF-YB, bin/biobas 37, 38 NF- e/transfac/ kDa) activator YA:NF- mouse, 7.4/bin/get stable required YB:NF- Mus vertebrate TFProf.cgi alpha:beta for T00613 NF-Y YC. musculus s ?T00613 reinitiation NULL http://local host/cgi- bin/biobas e/transfac/ mouse, 7.4/bin/get Mus vertebrate TFProf.cgi T00614 NF-Y NF-Y . musculus s ?T00614 NULL CBF-B (rat), http://local CP1B host/cgi- (all binds to (human, bin/biobas features Y-box rat), e/transfac/ for 346 elements HAP2 mouse, 7.4/bin/get AA form) of MHC (yeast), Mus vertebrate TFProf.cgi glutamine- class II T00615 NF-YA NF-YA. musculus s ?T00615 rich region genes NULL subunit of a trimeric as a DNA subunit of binding the NF-Y CBF-B complex complex, (rat), CP1- NF- interacts B, HAP2, YA:NF- directly HAP2 YB:NF- with two (yeast), YC, see subunits NF-YA <T00150> of the (mouse), physical RFX CP1B, http://local interaction complex, NFYA, host/cgi- (in vitro RFX5 CAAT- bin/biobas and in <T01672> box DNA e/transfac/ vivo) with and binding human, 7.4/bin/get ZHX1 RFXANK (cell protein Homo vertebrate TFProf.cgi <T04355> <T05441> lines:) T01804 NF-YA subunit A. sapiens s ?T01804 [2] [1]. HeLa CBF-A (rat), http://local subunit of CP1a host/cgi- the NF-Y binds to (human, bin/biobas trimeric Y-box rat), e/transfac/ transcripti elements HAP3 mouse, 7.4/bin/get on factor, of MHC (yeast), Mus vertebrate TFProf.cgi see class II T00616 NF-YB NF-YB. musculus s ?T00616 <T00613> genes NULL http://local host/cgi- bin/biobas e/transfac/ clawed 7.4/bin/get frog, vertebrate TFProf.cgi T05215 NF-YB Xenopus s ?T05215 NULL http://local host/cgi- bin/biobas e/transfac/ chick, 7.4/bin/get Gallus vertebrate TFProf.cgi T05216 NF-YB gallus s ?T05216 NULL forms the NF-Y factor complex <T00613> http://local together host/cgi- with NF- bin/biobas YA CBF-C e/transfac/ <T00615> (rat), mouse, 7.4/bin/get and NF- CP1C Mus vertebrate TFProf.cgi YB T02477 NF-YC (human). musculus s ?T02477 <T00616> transcripti ubiquitous onal activator [4] [5] [6] [1] may be antagoniz ed by ARP-1 and/or COUP- TF [7] [5] first step of activation by HNF-4 appears to involve recruitme nt of TFIIB, a HNF4, second HNF-4, step hepatocyt operates e nuclear through factor 4, the AF-2- hepatocyt http://local homologo e nuclear host/cgi- us factor bin/biobas activation 4alpha1, rat, e/transfac/ domain NR2A1, Rattus 7.4/bin/get forms [4] can liver, HNF- ARE norvegicu vertebrate TFProf.cgi homodime act as kidney, T00372 4alpha1 protein. s s ?T00372 rs. transcripti intestine the originally published 465-AA sequence may lack 9 N- http://local terminal hepatocyt host/cgi- amino e nuclear bin/biobas acid factor e/transfac/ residues 4alpha2, human, 7.4/bin/get of the liver, HNF- HNF-4B, Homo vertebrate TFProf.cgi authentic activator kidney, T00373 4alpha2 NR2A1. sapiens s ?T00373 protein [1] [1] intestine androgen exposure required for dimerizati on and subseque nt DNA- binding dimerizati on inhibited by region A/B [5] nuclear uptake may occur by constitutiv binding to ely [9] as androgen- well as responsiv hormone- e dependent elements, androgen http://local [10] [4] AR receptor, host/cgi- there may regulates AR, bin/biobas be tissue- expressio NR3C4, e/transfac/ specific n of dihydrotes human, 7.4/bin/get splice target tosterone Homo vertebrate TFProf.cgi variants genes [8] T00040 AR receptor. sapiens s ?T00040 [11] [5] NULL regulates androgen- dependent gene expressio n by binding to androgen- responsiv e elements (ARE) [4] its DNA- binding domain can interact with androgen http://local leucine receptor, host/cgi- zipper of AR, bin/biobas can form AP1 to NR3C4, rat, e/transfac/ multimeric result in dihydrotes Rattus 7.4/bin/get mutual tosterone norvegicu vertebrate TFProf.cgi complexe transrepre T00042 AR receptor. s s ?T00042 s [3] ssion [2]. NULL 1H NMR: 2 zinc ions coordinate d by 4 mediates http://local Cys gene host/cgi- within regulation ER, bin/biobas each zinc in estrogen rat, e/transfac/ finger 2 response receptor, Rattus 7.4/bin/get perpendic to NR3A1, norvegicu vertebrate TFProf.cgi ular alpha- estrogen T00258 ER-alpha ERalpha. s s ?T00258 helices hormone NULL activates transcripti on in response to estrogen hormones (e.g. estradiol) 1H NMR, [6] [2] crystal affinity for structure:estradiol 2 zinc (Kd 0,2 ions nM) coordinatehigher d by 4 than that Cys of within paralog each zinc ER-beta finger 2 <T04649> perpendic (Kd 0,5 nM) [2] ular alpha- helices interaction [9] [3] C- with terminal transcripti onal transcripti http://local on coactivato host/cgi- activatingr SRC-1 bin/biobas function <T04632> ER, e/transfac/ (TAF-2): estrogen mouse, 7.4/bin/get hormone- increases receptor, Mus vertebrate TFProf.cgi inducible transcripti T00259 ER-alpha NR3A1. musculus s ?T00259 [6] onal NULL 1 inducible estrogen- NLS also inducible inducible NLS by (nuclear hydroxy- localizatio tamoxifen, n signal) not by within ICI region E 164,384 [11] AF-1 [11] (activating discrimina function, tion over previously GRE- binding designate through d TAF-1): first zinc constitutiv finger: E- e, 203, G- independe 204, A- ntly active 206 TAF- [19] [7] in 1 is yeast, 3 constitutiv independe e, but cell- nt specific subdomai (active in ns are CEF, http://local active (1- poorly host/cgi- 62, 80- active in bin/biobas 113, 118- HeLa) ER, e/transfac/ 149) [7] [21] estrogen human, 7.4/bin/get activating estrogen- receptor, Homo vertebrate TFProf.cgi subdomai dependent T00261 ER-alpha NR3A1. sapiens s ?T00261 ns of AF- binding NULL can bind DNA as a homodime (adult:) r or as a expressed http://local heterodim in estrogen host/cgi- er thymus, receptor bin/biobas <T05702> testis, beta, e/transfac/ with ER- ovary [3]; NR3A2, human, 7.4/bin/get alpha agonist: weak ESTRB, Homo vertebrate TFProf.cgi <T00261> estradiol levels in T04651 ER-beta ESR2. sapiens s ?T04651 [4]. [3] spleen [3] activates transcripti on in response to ligand binding (estradiol) [1] affinity for estradiol (Kd 0,5 nM) lower than that of paralog ER-alpha <T00259> [1] activated interaction by Ras- with Raf-1- transcripti MAPK onal kinase coactivato and r SRC-1 MAPK <T04632> pathway: http://local therefore increases host/cgi- phosphory transcripti bin/biobas lation at onal NR3A2, e/transfac/ pos. 60 activity estrogen mouse, 7.4/bin/get (Serin) is (binding receptor Mus vertebrate TFProf.cgi important site (adult): T04649 ER-beta1 beta 1. musculus s ?T04649 [1] <R01906> ovary [1] binds to serum response element (SRE) embryo: increases day 18: with brain, myoblast heart, differentiat gizzard, ion skeletal required muscle for alpha- [1]; actin additional transcripti in day 10 on [1] in aorta stage 4 and in embryo: day 14 in epiblast, 4th aortic blood arch and islands abdominal [1] stage aorta [2]; 6 upregulate embryos: d in neural multinucle groove, ated neural (BudR for http://local plate, 60 hrs) host/cgi- primitive and bin/biobas streak, differentiat e/transfac/ lateral ed chick, 7.4/bin/get plate myotubes Gallus vertebrate TFProf.cgi phosphory mesoder (84 hrs T00761 SRF SRF. gallus s ?T00761 lation. m, BudR) [1] http://local host/cgi- bin/biobas binds to e/transfac/ serum 7.4/bin/get response cat, Felis vertebrate TFProf.cgi phosphory element T00762 SRF SRF. catus s ?T00762 lation (SRE) NULL C/EBPdelt http://local same a, CELF, host/cgi- DNA- ubiquitous CRP3, bin/biobas binding ; NF- rat, e/transfac/ specificity abundant IL6beta, Rattus 7.4/bin/get as in testis C/EBPdelt LF- norvegicu vertebrate TFProf.cgi C/EBPbet and T00109 a H3beta. s s ?T00109 a / NF-IL6 adrenal [2] stronger transcripti onal activator than C/BEPbet a both can act synergistic ally [3] undetecta ble levels in normal cells, but induced by LPS or inflammat ory cytokines [3] induction of C/EBPdelt a (in contrast http://local same to host/cgi- DNA- C/EBPbet bin/biobas binding a) by IL-6 C/EBPdelt e/transfac/ specificity is at the a, CRP3, human, 7.4/bin/get as transcripti C/EBPdelt NF- Homo vertebrate TFProf.cgi C/EBPbet onal level ubiquitous T00583 a IL6beta. sapiens s ?T00583 a / NF-IL6 [1] [3] strong transcripti on activator, synergistic ally acting with NF- kappaB, presumabl y by physical interaction [3] expressed very early during adipocyte differentiat ion, can be induced by adipogeni c hormones http://local same host/cgi- DNA- expressio C/EBPdelt bin/biobas binding n a, CELF, e/transfac/ specificity declines CRP3, mouse, 7.4/bin/get as before C/EBPdelt NF- Mus vertebrate TFProf.cgi C/EBPbet onset of ubiquitous T01114 a IL6beta. musculus s ?T01114 a / NF-IL6 C/EBPalp [4] Osf2, PEBP2alp haA, related to AML3, human PEBP2alp cleidocran haA1, ial Polyomavi dysplasia rus (CCD) [2] enhancer mapped binding to protein 2 chromoso alpha A me subunit, region CBF- 6p21 [2] alpha 1, factor essential RUNX2, was for Runt- found to skeletal related be morphoge transcripti associate nesis [2] on factor d with the controls 2, Core- nuclear the binding matrix [3] pathway factor, http://local 2 splice of alpha 1 host/cgi- variants differentiat subunit, bin/biobas AML3a ion into Acute e/transfac/ <T03983> the myeloid human, 7.4/bin/get and osteoblast leukemia Homo vertebrate TFProf.cgi AML3b lineage T02281 AML3 3 protein. sapiens s ?T02281 <T03984> [1] NULL major componen t of the Osf2, osteoblast PEBP2aA, -specific complex PEBP2A1, of CBF- primary alpha 1, osteoblast RUNX2, s [1] Runt- translation related al arrest transcripti of AML on factor proteins 2, Core- cause binding decrease factor, in alkaline alpha 1 phosphata subunit, se levels, Acute osteocalci myeloid immunore n levels, leukemia http://local active and a 3 protein, host/cgi- species reduced Osteoblas bin/biobas of 45, 60 number calvaria, t-specific rat, e/transfac/ and 65 of metaphysi transcripti Rattus 7.4/bin/get kDa in mineralize s, on factor norvegicu vertebrate TFProf.cgi Western d nodules epiphysis T02441 AML3 2. s s ?T02441 assay [1] [1] [1] related to human cleidocran ial dysplasia (CCD) [1] mapped to chromoso factor me PEBP2alp http://local was region ha1, host/cgi- found to 6p21 [1] Osf2, bin/biobas be essential PEBP2alp e/transfac/ associate for haA, CBF- human, 7.4/bin/get d with the skeletal alpha 1, Homo vertebrate TFProf.cgi nuclear morphoge T03983 AML3a RUNX2. sapiens s ?T03983 matrix [2] nesis [1] NULL does probably not heterodim erize with PEBP2bet a (Cbf beta) [1] expressio n occurs early during skeletal developm ent and is restricted to cells of the mesenchy mal condensat splice ions and variants the are osteblast <T01062> lineage and [4] http://local <T01063> PEBP2alp host/cgi- second haA (-/-) bin/biobas Met is the mice Osf2, e/transfac/ better scarcely CBFA1, mouse, 7.4/bin/get translation breathed, bone and PEBP2alp PEBP2alp Mus vertebrate TFProf.cgi al initiator showed osteoblast T02266 haA haA. musculus s ?T02266 in vitro [1] uniformly s [4] AML1, PEBP2alp haB, Acute myeloid leukemia 1 protein, Core- binding factor, alpha 2 related to subunit, t(8,21) RUNX1, acute CBF- myeloid alpha 2, splice leukemia Runt- variants cross- related are regulation transcripti AML1a between on factor <T02256> isoforms 1, , AML1b and Polyomavi http://local <T02245> familiy rus host/cgi- , AML1c members enhancer bin/biobas <T02246> at the binding e/transfac/ , transcripti protein 2 human, 7.4/bin/get AML1Delt onal level alpha B Homo vertebrate TFProf.cgi aN possible T01067 AML1 subunit. sapiens s ?T01067 <T02220> [1] NULL http://local host/cgi- bin/biobas gibbon e/transfac/ ape, 7.4/bin/get Hylobates vertebrate TFProf.cgi T02457 AML1 CBF. lar s ?T02457 NULL http://local 7 + 3 zinc Evi-1, host/cgi- finger ecotropic bin/biobas motifs involved virus e/transfac/ acidic in integration mouse, 7.4/bin/get region myeloid 1 site Mus vertebrate TFProf.cgi phosphory transform T00273 Evi-1 protein. musculus s ?T00273 lation ation NULL BPc, CBP, C/EBP, liver; C/EBPalp lower ha, http://local levels in EBP20, host/cgi- spleen, CCAAT/e bin/biobas kidney, nhancer clawed e/transfac/ ovary, binding frog, 7.4/bin/get oviduct; protein Xenopus vertebrate TFProf.cgi very low: T01388 C/EBP alpha. laevis s ?T01388 length: critically brain [1] 359 AA involved [13] or in energy 395 AA homeosta (ORF in sis and EMBL may have #M62362) a role in regulating alternative the balance translation between initiation cell product is growth C/EBPalp and ha (p30 differentiat variant) ion [21] BPc, <T02026> [12] [2] CBP, knock-out C/EBP, C/EBPalp mice are C/EBPalp ha unable to ha, exhibits a store EBP20, very hepatic p42(C/EB relaxed glycogen Palpha), DNA- and die p42C/EBP binding from alpha, specificity hypoglyce C/EBPalp http://local [23] the N- mia [2] ha(p42), host/cgi- terminal Myc/Max CCAAT/e bin/biobas part of heterodim nhancer e/transfac/ the ers bind binding mouse, 7.4/bin/get molecule to and C/EBPalp protein Mus vertebrate TFProf.cgi exhibits represses T00104 ha alpha. musculus s ?T00104 antimitotic the (liver) inhibits cell proliferatio n by enhancing the level of p21 (WAF-1) BPc, [1] this is CBP, due to C/EBP, enhanced C/EBPalp gene ha, http://local expressio EBP20, host/cgi- n and CCAAT/e bin/biobas posttransl nhancer e/transfac/ ational binding human, 7.4/bin/get stabilizatio C/EBPalp protein Homo vertebrate TFProf.cgi n of p21 T00105 ha alpha. sapiens s ?T00105 [1] NULL use of internal translation initiation codons may be due to leaky ribosome BPc, scanning, CBP, giving C/EBP, rise to C/EBPalp products ha, http://local of 40 kDa EBP20, host/cgi- (Met-15), CCAAT/e bin/biobas 29 kDa nhancer e/transfac/ (Met-102) binding chick, 7.4/bin/get and 14 C/EBPalp protein Gallus vertebrate TFProf.cgi kDa (Met- T00107 ha alpha. gallus s ?T00107 231) [1] NULL scissors- activator grip and [36] [37] helical- [18] fork required models for and for DNA- regulating binding the scissors terminal grip: upon adipocyte DNA- differentiat binding, ion [36] the alpha- [26] [4], helices of thereby the two reciprocall leucine y zippers regulated extend as and nonprolife towards prevented rating the basic by c-myc liver, regions [15] adipose, BPc, which expressed small CBP, make the only in intestine,a C/EBP, DNA- fully drenal C/EBPalp contacts differentiat gland, ha, [43] as a ed cells placenta, EBP20, result, [39] lung, LF- http://local dissociatio decreased brain, H3beta, host/cgi- n levels in skin [39]; CCAAT/e bin/biobas constant regenerati low levels nhancer rat, e/transfac/ for ng liver in muscle binding Rattus 7.4/bin/get homodime [17] and C/EBPalp protein norvegicu vertebrate TFProf.cgi rization repressor thymus T00108 ha alpha. s s ?T00108 increases at the [28] http://local inhibits host/cgi- DNA- CHOP- bin/biobas binding of 10, e/transfac/ C/EBPalp GADD mouse, 7.4/bin/get ha or 153 Mus vertebrate TFProf.cgi C/EBPbet liver T00127 CHOP-10 (hamster). musculus s ?T00127 a [1] enriched induced during growth arrest [2] and (mainly) http://local by signals chinese host/cgi- from hamster, bin/biobas stressed CHOP-10 Cricetulus e/transfac/ endoplas (mouse), 7.4/bin/get mic GADD GADD longicaud vertebrate TFProf.cgi reticulum liver T00299 153 153. atus s ?T00299 [1] enriched inducible by calcium ions [2] causes cell growth arrest at/around the G1/S checkpoin t [1] an oncogenic variant, TLS- CHOP, is associate d with adipose GADD the tissue 153, oncogenic myxoid CHOP, http://local variant liposarco growth host/cgi- TLS- ma it is arrest bin/biobas CHOP not and DNA- e/transfac/ has a capable damage- human, 7.4/bin/get large N- to induce GADD inducible Homo vertebrate TFProf.cgi terminal growth adipocyte T01387 153 gene 153. sapiens s ?T01387 extension arrest [1] s [1] may play a regulatory definitive role in adult developin erythrocyt http://local g chicken es, T host/cgi- brain and lymphocyt bin/biobas 2 zinc T-cell es, e/transfac/ finger specific embryonic chick, 7.4/bin/get motifs pI gene brain, GATA-3, Gallus vertebrate TFProf.cgi (calc.) = expressio adult T00314 GATA-3 NF-E1c. gallus s ?T00314 9.9 n kidney [7] peroxisom e proliferato r- http://local activated host/cgi- receptor bin/biobas control of gamma, clawed e/transfac/ peroxisom fat body, PPARgam frog, 7.4/bin/get al beta- kidney; PPAR- ma, Xenopus vertebrate TFProf.cgi oxidation (weaker: T01354 gamma NR1C3. laevis s ?T01354 pathway liver) activator as a one of heterodim two er with known RXR- isoforms alpha produced member form of the alternative steroid hormone promoters receptor and by superfamil alternative y splicing expressio [3], see n is under peroxisom mouse control of e PPAR- C/EBPbet proliferato gamma a, r- http://local <T05347> probably activated host/cgi- and synergizin receptor bin/biobas mouse g with gamma, e/transfac/ PPAR- C/EBPdelt PPARgam mouse, 7.4/bin/get gamma2 a, and of PPAR- ma, Mus vertebrate TFProf.cgi <T05332> glucocorti T02529 gamma1 NR1C3. musculus s ?T02529 . coids [2] NULL One of activator four as a known heterodim variants er with of RXR- <T05351> alpha predomin PPARgam ant ma2 is a isoform of isoform PPAR- with 28 gamma in additional man [7] N- ligands: adipocyte terminal fibrates, s, bone aminoacid fatty marrow, s in acids, skeletal compariso prostanoid muscle, peroxisom n with s, spleen, e gamma1 thiazolidin testis, proliferato [8] ediones brain and r- PPARgam (anti- liver [8]; activated ma binds diabetic adipocyte receptor, to DNA drugs) [9] s, large peroxisom as a one of intestine e heterodim the key (high proliferato er with regulators level), r- http://local the of kidney, activated host/cgi- retinoid X adipogene liver, receptor bin/biobas receptor sis small gamma, e/transfac/ (RXR) mRNA for intestine PPARgam human, 7.4/bin/get <T01345> gamma1 (intermedi PPAR- ma, Homo vertebrate TFProf.cgi , is slow ate level) T02736 gamma1 NR1C3. sapiens s ?T02736 <T01334> and [7] (adult:) weak levels in adipose tissue, spleen, lung, peroxisom ovary, e mammary proliferato isoform gland, r- <T04780> small activated http://local contains intestine receptor host/cgi- 30 [1]; very gamma, bin/biobas additional weak PPARgam e/transfac/ N- levels in ma, cattle, 7.4/bin/get terminal kidney, PPAR- NR1C3, Bos vertebrate TFProf.cgi amino muscle, T04794 gamma1 PPARG. taurus s ?T04794 acids heart [1] One of activator four as a known heterodim variants er with of RXR- <T05351> alpha [6] PPARgam PPARgam ma2 is ma2 minor binds to isoform in PPREs man [6] (PPARga ligands: mma fibrates, response fatty elements) acids, as a prostanoid peroxisom heterodim s, e er with thiazolidin proliferato retinoid X ediones r- receptor (anti- adipocyte activated (RXR) diabetic s, bone receptor <T01345> drugs) [9] marrow, gamma, , overexpre skeletal PPARgam <T01334> sssion of muscle, ma, [5] PPARgam spleen, NR1C3, PPARgam ma2 in testis, peroxisom http://local ma2 and fibroblast brain and e- host/cgi- RXR cell lines liver [8]; proliferato bin/biobas <T01345> converts heart, r- e/transfac/ , them to pancreas activated human, 7.4/bin/get <T01334> adipocyte [5]; PPAR- receptor Homo vertebrate TFProf.cgi s [10] adipocyte T03731 gamma2 gamma 2. sapiens s ?T03731 cooperativ PPARgam s [6] (adult:) high levels in adipose tissue, spleen, lung [1]; lower peroxisom levels in e ovary, proliferato mammary r- gland, activated http://local small receptor host/cgi- intestine gamma, bin/biobas [1]; very PPARgam e/transfac/ low levels ma, cattle, 7.4/bin/get in kidney, PPAR- NR1C3, Bos vertebrate TFProf.cgi muscle, T04780 gamma2 PPARG. taurus s ?T04780 heart [1] http://local host/cgi- bin/biobas (Jun)2, e/transfac/ AP1, clawed 7.4/bin/get Fos/Jun, frog, vertebrate TFProf.cgi T00027 AP-1 PEA1. Xenopus s ?T00027 (oocytes) composed of two subunits: two Jun- down- peptides modulated or one by Jun- glucocorti http://local <T00133> coids host/cgi- and one through (Jun)2, bin/biobas Fos- direct AP1, e/transfac/ peptide interaction Fos/Jun, human, 7.4/bin/get <T00123> with GR PEA1 Homo vertebrate TFProf.cgi (or induced T00029 AP-1 (mouse). sapiens s ?T00029 relatives) by TPA [1] NULL http://local host/cgi- (Jun)2, bin/biobas AP1, monkey, e/transfac/ Fos/Jun, Cercopith 7.4/bin/get PEA1 ecus vertebrate TFProf.cgi Phosphor T00030 AP-1 (mouse). aethiops s ?T00030 ylation (COS-7) composed of two subunits: two Jun- peptides or one Jun- http://local <T00132> host/cgi- and one (Jun)2, bin/biobas Fos- AP1, rat, e/transfac/ peptide Fos/Jun, Rattus 7.4/bin/get <T00124> PEA1 norvegicu vertebrate TFProf.cgi (or T00031 AP-1 (mouse). s s ?T00031 relatives) NULL AP-1 level composed decreases of two in murine subunits: mammary two Jun- epithelial peptides cells or one upon Jun- differentiat http://local <T00131> ion (Jun)2, host/cgi- and one induced AP1, bin/biobas Fos- by Fos/Jun, e/transfac/ peptide dexameth PEA1, mouse, 7.4/bin/get <T00122> asone or PEA1 Mus vertebrate TFProf.cgi (or prolactin T00032 AP-1 (mouse). musculus s ?T00032 relatives) [2] NULL http://local host/cgi- bin/biobas e/transfac/ 7.4/bin/get vertebrate TFProf.cgi T01115 AP-1 AP1. hamster s ?T01115 NULL http://local host/cgi- bin/biobas e/transfac/ chick, 7.4/bin/get AP1, Gallus vertebrate TFProf.cgi T01140 AP-1 PEA1. gallus s ?T01140 NULL http://local host/cgi- mediates bin/biobas phorbol gibbon e/transfac/ ester ape, 7.4/bin/get responses Hylobates vertebrate TFProf.cgi through T01156 AP-1 AP1. lar s ?T01156 TRE NULL http://local host/cgi- fruit fly, bin/biobas Drosophil e/transfac/ a 7.4/bin/get melanoga vertebrate TFProf.cgi T01132 AP-1 AP1. ster s ?T01132 involved NULL in response to oxidative stress/oxy gen detoxificat ion and metal resistance [6] similar to, but different from GCN4 an upstream ORF allows 40S subunits to proceed via leaky scanning AP1, http://local and re- yAP1, host/cgi- initiation PAR1, bin/biobas to the PDR4, yeast, e/transfac/ major SNQ3, Saccharo 7.4/bin/get ORF [4] YML007W myces vertebrate TFProf.cgi thioredoxi T00028 YAP1 . cerevisiae s ?T00028 n system NULL TALE acts as a (three repressor amino of RXR- acid loop alpha extension) <T01345> homeo domain dependent superclas s [6] [8] transcripti SMAD-2 onal (adult:) <T04095> activation highly by mutual expressed dependent exclusive in binding placenta, interaction [8] CPR prostate, with Fast- (cell cycle testis, 2 progressio ovary, <T04100> n small [5] restoratio intestine competes n) gene, and with p300 overexpre colon, <T01427> ssion can weakly for overcome expressed binding to G1 arrest in lung, the signals in liver, SMAD-2 the yeast kidney, http://local <T04095> cell cycle pankres, 5 TG3 host/cgi- complex [7] spleen, interacting bin/biobas [5] interacts thymus, factor, e/transfac/ competitiv with blood TG- human, 7.4/bin/get e binding SMAD-2 leukocytes interacting Homo vertebrate TFProf.cgi with Meis- <T04095> , spinal T04076 TGIF factor. sapiens s ?T04076 2 and cord [8] (embryo 12 days:) 1. branchial TALE arch, lung (three bud, amino duodenu acid loop m, extension) hindlimb homeo buds, domain brain, superclas (embryo s [1] [2] probably 15 days:) 89% regulates hippocam amino target pal acid genes formation, identity to involved human in the mesencep TGIF proliferatio h. vesicle, <T04076> n, cerebellar [2] migation plate, specificall and/or vertebra, y differentiat kidney, expressed ion of intestine, http://local in the particular thymus, 5 TG3 host/cgi- developin neuronal upper interacting bin/biobas g cell molars, factor, e/transfac/ cerebellu lineages tongue, TG- mouse, 7.4/bin/get m and in the (adult:) interacting Mus vertebrate TFProf.cgi hippocam developin prolif. T04077 TGIF factor. musculus s ?T04077 pus [2] g brain [2] cells [2] involved in http://local regulation host/cgi- of liver bin/biobas and liver rat, e/transfac/ intestinal (intestine, HNF3B, Rattus 7.4/bin/get gene lung, HNF3beta norvegicu vertebrate TFProf.cgi expressio stomach, T01049 HNF-3B . s s ?T01049 n [2] ovary) gene locus is very close to locus of Fkh-6 <T02417> [5] K.O. mice die in most (embryoni cases c) prenatally mesoder (beginning m 13.5 (earlier), dpc) mesenchy surviving me and animals derivative show s (later, severe mainly cranofacia head l and region) vertebral [6], dorsal defects, aortas which [4]; Mesenchy may be (adult) me fork due to the muscle, head 1, http://local marked heart, Fkh-14, host/cgi- reduction kidney, Fork bin/biobas gene is in the (weaker head e/transfac/ located proliferatio in) brain, homolog mouse, 7.4/bin/get on n and fat, lung, 14, MFH- Mus vertebrate TFProf.cgi chromoso (probably) liver, T02445 FOXC2 1. musculus s ?T02445 me 8 [5] the gonads [5] possibly functions as an inhibitor of differentiat ion in early stages of thyroid developm ent, perhaps by interfering with transcripti onal activation of thyroid- specific gene expressio http://local n by TTF- host/cgi- 1 bin/biobas <T00856> rat, e/transfac/ and Pax- Rattus 7.4/bin/get 8 (thyroid norvegicu vertebrate TFProf.cgi <T01829> FRTL T01133 FOXE1 TTF-2. s s ?T01133 [1] cells) (embryoni c) extraembr yonic and lateral mesoder m, splanchni c mesoder m [2]; (adult) weak in prostate and placenta, moderate in colon and small HNF- intestine 3/Fkh [2], type II Homolog http://local pneumocy 8, Freac- host/cgi- tes [3] 1 bin/biobas and (Forkhead e/transfac/ fibroblasts RElated mouse, 7.4/bin/get [2] of ACtivator- Mus vertebrate TFProf.cgi alveolar T02461 FOXF1 1), HFH-8. musculus s ?T02461 sac (fetal) lung, brain (weak); sequence (adult) not placenta, http://local complete, lung, Forkhead host/cgi- translation (weaker RElated bin/biobas start has in) ACtivator- e/transfac/ not yet prostate, 2, human, 7.4/bin/get been small FKHL6, Homo vertebrate TFProf.cgi determine intestine, T02465 FOXF2 FREAC2. sapiens s ?T02465 d [2] colon is a transactiv ator for the lung surfactant protein B (SBP) promotor <G001045 > the C- terminal (adult) half of the bronchiola protein r http://local contains epithelial host/cgi- two cells and bin/biobas transactiv type II e/transfac/ gene is ating pneumocy mouse, 7.4/bin/get composed domains tes, small Mus vertebrate TFProf.cgi of 2 C and D intestine T02514 FOXF2 LUN. musculus s ?T02514 exons [1] [1] (weak) a complex is formed in response to TGF- SMAD-2 beta <T04095> treatment which dependent binds to ARE interaction (Activin with Response TGIF Element) <T04076> and to a Fast- includes SMAD- at least http://local TGIF three forkhead host/cgi- complex proteins, activin bin/biobas [3] FAST-2, signal e/transfac/ interaction SMAD-2 transduce mouse, 7.4/bin/get with and r 2, FAST- Mus vertebrate TFProf.cgi SMAD-3 SMAD-4 T04100 FOXH2 2, FAST2. musculus s ?T04100 [2]. [2]. NULL (embryoni c) visceral endoderm [3]; (adult) brain cortex http://local (weak), host/cgi- bronchiola bin/biobas gene is r HNF- e/transfac/ located epithelium 3/Fkh mouse, 7.4/bin/get on (clara Homolog Mus vertebrate TFProf.cgi chromoso activator cells) [5], T02460 FOXJ1 4, HFH-4. musculus s ?T02460 me 11 [5] [4] testis [2] binds to (fetus:) two liver [1], different (adult:) types of spleen, sequence thymus, s, so prostate, FOXJ2 testis, may bind ovary, DNA in small two intestine, different colon, independe leukocytes nt , heart, manners brain, [1] two placenta, splice lung, variants: liver, one long skel. and one muscle, short kidney, <T04171> pancreas, isoform (cell which lines:) differ in transcripti NIN3T3, expressio onal ES-2, http://local n level activator Chang, FHX.L, host/cgi- and [1] [2] C33, fork head bin/biobas transcripti may be COS, homologo e/transfac/ onal involved HeLa, FOXJ2 us X, human, 7.4/bin/get activation in early Hep3B, (long long Homo vertebrate TFProf.cgi potential developm H5, UT-7 T04169 isoform) isoform. sapiens s ?T04169 [2] ent [1] [2] ILF-1, http://local interleukin host/cgi- bin/biobas fork head enhancer e/transfac/ domain binding human, 7.4/bin/get essential (cell factor 1, Homo vertebrate TFProf.cgi for DNA- lines:) T01088 FOXK1a ILF. sapiens s ?T01088 binding [2] HeLa [2] alternative splice does not form of acts as a the HFH- transcripti 11 gene onal that activator, contains although 2 the additional alternative exons [3] ly spliced the gene protein consists <T02516> of 10+ does (on exons an (very artificial unusual promoter) for fork the head additional HNF- http://local genes) exon A2 3/Fkh host/cgi- the gene causes Homolog bin/biobas is located the loss studied 11A, e/transfac/ on of only in FKHL16A, human, 7.4/bin/get chromoso transactiv mouse so HFH- Homo vertebrate TFProf.cgi me ating far, see T02517 FOXM1a 11A. sapiens s ?T02517 12p13 [2] activity [3] <T02515> spliceform of the HFH-11 gene, that lacks 2 exons the gene consists of 10+ acts as exons transcripti (very onal unusual activator for fork on an head artificial genes) promoter http://local [3] the the host/cgi- gene is alternativl bin/biobas located y spliced studied e/transfac/ on protein only in human, 7.4/bin/get chromoso <T02517> mouse so Homo vertebrate TFProf.cgi me does not far, see T02516 FOXM1b HFH-11B. sapiens s ?T02516 12p13 [2] [3] <T02515> binds to HTLF, http://local the human T- host/cgi- human T- cell bin/biobas cell leukemia e/transfac/ leukemia virus human, 7.4/bin/get virus long enhancer Homo vertebrate TFProf.cgi terminal T04206 FOXN2 factor. sapiens s ?T04206 repeat [1] NULL chromoso activator, mal PAX3- translocati FKHR on t(2 fusion 13)(q35 protein is q14) a more causing potent alveolar transcripti rhabdomy onal osarcoma activator s fuses than the Pax-3(1- normal 391) with PAX3 FKHR [4] although [5] in the PAX3- binding to FKHR the the e5 forkhead recognitio domain of n FKHR is sequence destroyed is while the significantl homeodo y main and impaired paired compaired domain of to PAX3 (adult:) http://local Pax-3 are [5] [3] in brain, host/cgi- retained response blood, bin/biobas [3] 86% to insulin colon, e/transfac/ identical AKT-1 kidney, ALV, human, 7.4/bin/get to represses ovary, FKHR, Homo vertebrate TFProf.cgi FKHRL1 transcripti skeletal, T02936 FOXO1a FKH1. sapiens s ?T02936 [2] onal muscle [2] may have regulatory roles in immune response [5] the serine/thr eonine kinase Akt prevents FOXO3a dependent transcripti on by phosphory lation (T32, S253), phosphory lated FOXA3a (adult:) is brain, retained blood, in the colon, http://local cytoplasm kidney, host/cgi- 86% by ovary, bin/biobas identical binding to skeletal, e/transfac/ to the muscle human, 7.4/bin/get FOXO1a scaffold [4], T Homo vertebrate TFProf.cgi <T02936> protein helper T02938 FOXO3a FKHRL1. sapiens s ?T02938 [4] 14-3-3 cells [5] translocati on t(X 11)(q13 q23) with the MLL (mixed- http://local lineage host/cgi- leukemia) bin/biobas gene can e/transfac/ cause human, 7.4/bin/get acute AFX, Homo vertebrate TFProf.cgi leukemia B-cells, T- T03403 FOXO4 AFX-1. sapiens s ?T03403 [1] cells [1] zinc finger region binds specificall y to DNA POZ (POx virus and Zinc finger) domain, which is a http://local protein- zinc host/cgi- protein finger bin/biobas contact protein e/transfac/ region, is with human, 7.4/bin/get inhibitory interaction Homo vertebrate TFProf.cgi for DNA- T01468 ZID domain. sapiens s ?T01468 binding NULL http://local host/cgi- bin/biobas rat, e/transfac/ Rattus 7.4/bin/get HP1 site HP1 site norvegicu vertebrate TFProf.cgi T00379 factor factor. s s ?T00379 NULL activator [2] may be involved in transcripti onal 6 zinc initiation fingers of and C2H2- terminatio type [3] n at the c- proline- myc P2 /alanine- promoter rich [1] may region [1] be an may have important an N- regulator terminal of TATA- extension less MAZ, leading to promoters ZF87, a 87 kDa [2] may Zif87, protein as function Myc- mentioned in associate in [3] establishin d zinc homologo g active finger us to the transcripti protein, http://local rodent on Pur-1, host/cgi- factors complexe purine- bin/biobas Pur-1 s on the binding e/transfac/ <T02303> serotonin transcripti human, 7.4/bin/get 1a on factor Homo vertebrate TFProf.cgi <T02304> receptor T00490 MAZ 1. sapiens s ?T00490 [4] gene NULL contains zinc fingers of C2H2 type [1] homologo us to the Myc- human associate factor d zinc MAZ finger <T00490> protein, http://local [1] Pur-1, host/cgi- equivalent purine- bin/biobas in binding e/transfac/ hamster transcripti mouse, 7.4/bin/get is on factor Mus vertebrate TFProf.cgi <T02304> T02303 MAZ 1. musculus s ?T02303 [1] NULL protein sequence may be incomplet e [1] activator contains [2] binds zinc to purine- fingers of rich C2H2 region Myc- type [2] (GAGA- associate homologo box) in d zinc us to the insulin finger human and protein, http://local factor human Pur-1, golden host/cgi- MAZ islet purine- (Syrian) bin/biobas <T00490> amyloid binding hamster, e/transfac/ and to polypeptid transcripti Mesocrice 7.4/bin/get <T02303> e on factor tus vertebrate TFProf.cgi in mouse promoters T02304 MAZ 1. auratus s ?T02304 [2] [2] NULL class A type domain C- terminally adjacent to the bHLH motif may comprise a novel loop-helix motif in the trans- activating region as suggested thymus, by T-cell similarity lines; with E2A lower in and E2-2 brain, http://local gene transcripti kidney, host/cgi- products onal ovary; bin/biobas and activator, moderate e/transfac/ Daughterl binding to in lung; HTF4, human, 7.4/bin/get ess E box low in HTF4A, Homo vertebrate TFProf.cgi (Drosophil elements skeletal T01503 HEB TCF-12. sapiens s ?T01503 a) [2] [4] muscle [4] all identified SOX proteins contain HMG may play domains a key role which in bone facilitate formation sequence- and testis specific developm DNA- ent [2] binding gene and found share close to more the than 50% breakpoint identity of t(2 with the 17)(q35 HMG q23-24) domain of chromoso SRY mal (human translocati testis- on determinin causing highest g factor) campomel levels in http://local most of ic adult host/cgi- the SOX dysplasia, testis, SRY- bin/biobas proteins a skeletal lower in related e/transfac/ share a malformati fetal HMG-box human, 7.4/bin/get core DNA- on brain, protein 9, Homo vertebrate TFProf.cgi binding syndrome liver, T01853 SOX-9 SOX9. sapiens s ?T01853 sequence [2] [3] kidney [3] solution structure similar to that of HMG1 [1] overlappin g DNA- binding specificity with SRY [2] binds to AACAAT with KD = 1 nM [1] DNA- binding in a 1:1 stoichiom etry does post- http://local not affect meiotic host/cgi- the germ bin/biobas protein cells; SRY- e/transfac/ structure, round related mouse, 7.4/bin/get but bends spermatid HMG-box Mus vertebrate TFProf.cgi the DNA s (highest T01429 Sox-5 gene 5. musculus s ?T01429 [1] level) [2] http://local host/cgi- EF-C, bin/biobas RFX, RF- e/transfac/ ubiquitous X, mouse, 7.4/bin/get ; highest enhancer Mus vertebrate TFProf.cgi level in T01666 RFX1 factor C. musculus s ?T01666 testis [1] member homodime of winged- rs can helix function class of as helix-turn- activators helix or superclas repressor s of s factors [2] depending the DBD on the exhibits a nature of weak interaction sequence s similarity between to the two bHLH subunits, domain two consensu distinct s and is types of predicted homodime to rs can be constitute formed two which are amphipath different ic helices in their and a function http://local linking [5] [7] [6] ubiquitous EF-C, host/cgi- loop [14] preferenti , highly RFX, RF- bin/biobas it binds to al binding expressed X, e/transfac/ DNA as a to in enhancer human, 7.4/bin/get dimer, methylate primary factor C, Homo vertebrate TFProf.cgi but d eosinophil T01673 RFX1 hRFX1. sapiens s ?T01673 dimerizati sequence s [4] potent activator as homo- or heterodim er with RelA <T00594> [10] [3], overlappin but may g DNA- also binding repress specificity trans- with NF- activation kappaB by <T00590> induced exclusive RelA [2] binding relA gene to, e. g., is intronic activated enhancer by RelA, of IFN- but gamma repressed gene by c-Rel (AGGGAT itself [2] TT) [9] DNA- http://local trans- binding host/cgi- activation by c-Rel bin/biobas through is c-Rel, e/transfac/ physical induced HIVEN86 human, 7.4/bin/get interaction by HTLV- A, p82(hc- Homo vertebrate TFProf.cgi with TBP I Tax [4] T00168 c-Rel rel), p68. sapiens s ?T00168 [5] which (HeLa) c-Rel heterodim ers with potent NF- acivator kappaB1 [6] [5] (p50) early prevail in growth mature B response cells in gene [8] contrast may to pre-B substitute cells, RelA where (p65) p50/RelA during B- heterodim cell ers maturatio predomin n thus ate [1] c- contributin Rel/p50 g to the dimers constitutiv bind 20- e fold more expressio stably to n of the immunogl intronic obulin kappaB genes [1] http://local site of the c-rel host/cgi- Igkappa expressio bin/biobas gene than n is c-Rel, e/transfac/ p50/RelA augmente HIVEN86 mouse, 7.4/bin/get dimers [1] d in A, p82(hc- Mus vertebrate TFProf.cgi the potent mature B T00169 c-Rel rel), p68. musculus s ?T00169 C- cells [1] NULL high levels: http://local apoptotic c-Rel, host/cgi- trans- or p82(hc- bin/biobas activation autophago rel), p68, e/transfac/ domains cytotic HIVEN86 chick, 7.4/bin/get contact potent cells; low: A Gallus vertebrate TFProf.cgi TBP activator ubiquitous T01154 c-Rel (human). gallus s ?T01154 directly [2] [5] [9] [1] for expressio n in teeth, see [6] rescues unc-30 <T03371> mutant phenotype of C. elegans [2] regulator of http://local GABAergi Ptx-2, host/cgi- c Pitx2, bin/biobas differentiat RGS, e/transfac/ ion during Otlx2, mouse, 7.4/bin/get neural RIEG, Mus vertebrate TFProf.cgi developm T02410 Pitx2 Ptx2. musculus s ?T02410 ent [2] NULL POU1F1 mutations (Pit-1) cause <T00691> Rieger syndrome physically (ocular interacts anterior with chamber PITX2 to anomalies facititate causing DNA glaucoma, binding dental [3] hypoplasi mutant a, mild PITX2 craniofaci (T68P) al has dysmorphi reduced sm, DNA umbilical binding stump specificity, abnormalit lacks ies, transactiv abnormal ation cardiac, activity [3] limb and mutant pituitary PITX2 developm http://local (L54Q) is ent) [4] Ptx-2, host/cgi- an activator, Pitx2, bin/biobas unstable interacts RGS, e/transfac/ protein [3] with Otlx2, human, 7.4/bin/get C- POUF1 RIEG, Homo vertebrate TFProf.cgi terminus (Pit-1) T02413 PITX2 Ptx2. sapiens s ?T02413 represses <T00691> NULL repressor of apolipopro tein AI and CIII genes [11], of forms the homodime human rs, can erythropoi bind as etin monomer promoter or [7] homodime activator r [6] loss of the of mouse dimerizati LPL on promoter function [4], leads to a FABPI loss of promoter DNA- [8], rat binding CYP7A ARP-1, unless it [2], COUP- is C- salmon beta, terminally HNF-1 apolipopro http://local truncated promoter tein AI host/cgi- to AA 171 [1] regulatory bin/biobas can bind participate protein, e/transfac/ to DR0, s in NR2F2, human, 7.4/bin/get DR4 regulation COUP- Homo vertebrate TFProf.cgi elements of lipid widesprea T00045 ARP-1 TF II. sapiens s ?T00045 [2] metabolis d activator as a heterodim er with RXR- alpha regulator of the physiologi cal response to xenobiotic s in a complex cross-talk with PXR (NR1I2) forms [3] [2] heterodim activating ers with ligand: RXR- xenobiotic NR1I3, alpha, 5beta- phenobar which is pregnane- preferenti bital necessary 3,20- ally in receptor, for DNA dione, liver; low constitutiv http://local binding that is levels in e host/cgi- and common heart and androstan bin/biobas transcripti for the muscle, e e/transfac/ on human lesser receptor, human, 7.4/bin/get activation and levels in MB67 Homo vertebrate TFProf.cgi <T05676> mouse kidney T02261 CAR (human). sapiens s ?T02261 . PXR-1 [3] and lung activator [5] [4] [3] [1] recognize s retinoic acid response elements (RAREs) of DR5 type [5] [3] recognize s DR4 elements [4] [3] [1], DR3 elements [3] [1], ER6 heterodim elements er, for [3] individual activates polypeptid gene es see encoding mouse the http://local CAR enzyme host/cgi- <T05687> of the bin/biobas and peroxisom e/transfac/ mouse al beta- mouse, 7.4/bin/get RXR- oxidation CAR:RXR Mus vertebrate TFProf.cgi alpha pathway, T05257 -alpha musculus s ?T05257 <T01331> hydratase/ NULL heterodim er for individual polypeptid http://local es see rat host/cgi- CAR bin/biobas <T05312> rat, e/transfac/ and rat Rattus 7.4/bin/get RXR- CAR:RXR norvegicu vertebrate TFProf.cgi alpha activator T05315 -alpha s s ?T05315 <T04383> [1] NULL activator binds to and activates transcripti on through different types of response elements: DR5/RAR E, DR4 [2] [1] [4], DR3 [3], ER6/IR6 [3] [4] activates cyp2b and heterodim cyp3a er for genes in individual response polypeptid to es see phenobar human bital [4] http://local CAR regulator host/cgi- <T02261> of bin/biobas and xenobiotic e/transfac/ human response human, 7.4/bin/get RXR- in a CAR:RXR Homo vertebrate TFProf.cgi alpha complex T05676 -alpha sapiens s ?T05676 <T01345> interplay NULL COUP, COUP- TF, chicken http://local member ovalbumin host/cgi- of the bin/biobas steroid upstream rat, e/transfac/ hormone promoter Rattus 7.4/bin/get mixture of receptor transcripti norvegicu vertebrate TFProf.cgi different superfamil T00147 COUP on factor. s s ?T00147 isoforms y NULL COUP- TF, chicken http://local ovalbumin host/cgi- bin/biobas upstream e/transfac/ promoter mouse, 7.4/bin/get transcripti Mus vertebrate TFProf.cgi T00994 COUP-TF on factor. musculus s ?T00994 NULL repressor represses RXR- mediated activation and retinoic acid COUP, responses COUP- also TF, antagoniz EAR3, es HNF-4- COUP- mediated alpha, activation NR2F1, [6] [3] chicken http://local competitiv ovalbumin host/cgi- ely binds bin/biobas to XRE upstream e/transfac/ with promoter human, 7.4/bin/get AhR:Arnt COUP- transcripti Homo vertebrate TFProf.cgi heterodim T00149 TF1 on factor. sapiens s ?T00149 er [1] (HeLa) activation by oxysterols (natural ligands): 24(S),25- epoxychol esterol, 24(S)- heterodim hydroxych erization olesterol with RXR- and alpha 22(R)- <T01345> hydroxych [6]: olesterol binding of [4] [3] this ligand heterodim selectivity er to DR4- distinct like from NR1H3, sequence isoform LXR, liver s in <T04453> X contrast (stronger receptor no binding to alpha, formation 5,6- nuclear of a 24(S),25- orphan http://local biological di- receptor host/cgi- active epoxychol LXR- bin/biobas heterodim esterol) alpha, e/transfac/ er [3] LXRA, human, 7.4/bin/get together heterodim LXR- LXR A, Homo vertebrate TFProf.cgi with RAR- er with T02752 alpha LXR-A. sapiens s ?T02752 alpha [6]. RXR- NULL activator as a heterodim er with RXR- alpha [1] [3] seems to link fatty acid and cholestero l forms metabolis NR1H3, heterodim m via RLD1, ers with induction LXR, RXR- of oxysterol alpha [1] SREBP- (embryo:) receptor [3] 1c gene probably LXRalpha, conflict in expressio weak liver X protein n expressio receptor sequence <G002466 n starting alpha, between > [1] at nuclear EMBL activates embryonic orphan entry transcripti day 13.5 receptor #AJ13259 on of (rat) that LXR- 9 (pos. cholestero increases alpha, http://local 399:R) l 7alpha- in oxysterol host/cgi- and hydroxyla abundanc receptor bin/biobas SWISSPR se gene e up to LXR- e/transfac/ OT entry (CYP7A) birth [2]; alpha, mouse, 7.4/bin/get #Q9Z0Y9 <G001194 peritoneal LXR- LXR A, Mus vertebrate TFProf.cgi (pos. > in vitro macropha T04430 alpha LXR-A. musculus s ?T04430 399:P). (CYP7A ges [4] (adult:) strong in spleen [1] [2], pituitary gland, fat tissue, lung [2] and in metabolic organs P-Box such as (contribut liver, NR1H3, es in kidney, RLD1, general to as intestine LXR, DNA- heterodim [1]; weak oxysterol binding er with rat in receptor specifity) RXRalpha prostate, LXRalpha, in DNA- skin [2] liver X binding <T04383> and receptor domain is probably alpha, conserved transcripti in nuclear [2] onal adrenals orphan probably activation [1], receptor weak of stomach LXR- binding to reporter [2]; alpha, http://local retinoic- genes unclear oxysterol host/cgi- acid linked to wether receptor bin/biobas response artificial low levels LXR- rat, e/transfac/ element DR-4 like in testis alpha, Rattus 7.4/bin/get beta repeat are LXR- LXR A, norvegicu vertebrate TFProf.cgi (RARE- <R09934> present T04434 alpha LXR-A. s s ?T04434 beta) [2] [2] or not activator upon induction by oxysterols [2] [1] classical binding DNA element is DR4 regulates heterodim cholestero er, for l individual catabolis polypeptid m into es see bile acids mouse by LXR- induction http://local alpha of CYP7A host/cgi- <T04430> [2] can bin/biobas and act e/transfac/ mouse synergistic LXR- mouse, 7.4/bin/get RXR- ally with alpha:RX Mus vertebrate TFProf.cgi alpha LRH-1 T05320 R-alpha musculus s ?T05320 <T01331> (FTF) [2] NULL activator [1] [2] classical binding DNA heterodim element er, for is DR4 individual regulates polypeptid lipid es see metabolis human m in liver LXR- [1] http://local alpha regulates host/cgi- <T02752> cholestero bin/biobas and l efflux e/transfac/ human from lipid- LXR- human, 7.4/bin/get RXR- loaded alpha:RX Homo vertebrate TFProf.cgi alpha macropha T05324 R-alpha sapiens s ?T05324 <T01345> ges [2] NULL heterodim er, for individual polypeptid es see rat http://local LXR- host/cgi- alpha bin/biobas <T04434> rat, e/transfac/ and rat LXR- Rattus 7.4/bin/get RXR- alpha:RX norvegicu vertebrate TFProf.cgi alpha activator T05357 R-alpha s s ?T05357 functional NULL <T04383> [1] activation by oxysterols 24(S),25- epoxychol esterol, 24(S)- hydroxych olesterol and 22(R)- hydroxych olesterol [3] [2] NR1H2, ligand oxysterol selectivity receptor distinct LXR- from beta, isoform nuclear <T02752> orphan (weaker receptor binding to LXR- 5,6- beta, 24(S),25- ubiquitous di- ly http://local epoxychol expressed host/cgi- esterol) nuclear bin/biobas [2] receptor, e/transfac/ heterodim LXRB, human, 7.4/bin/get erization UR, LXR Homo vertebrate TFProf.cgi with RXR- T04453 LXR-beta B, NER. sapiens s ?T04453 alpha NULL NR1H2, oxysterol receptor LXR- seems to beta, binds to link fatty nuclear DNA acid and orphan elements cholestero receptor as a l LXR- heterodim metabolis beta, er with m via ubiquitous RXR- induction ly alpha, of expressed see SREBP- nuclear <T05701> 1c gene receptor, [2] does expressio orphan http://local not bind n nuclear host/cgi- to DNA <G002466 receptor bin/biobas as a > (as a OR-1, e/transfac/ monomer heterodim LXRB, mouse, 7.4/bin/get or er with peritoneal UR, LXR Mus vertebrate TFProf.cgi homodime RXR- macropha T04467 LXR-beta B, NER. musculus s ?T04467 r [3]. alpha) [1]. ges [2] heterodim er, for activator individual [1] polypeptid classical es see binding human DNA http://local LXR-beta element host/cgi- <T04453> is DR4 [1] bin/biobas and [2] e/transfac/ human activates LXR- human, 7.4/bin/get RXR- human beta:RXR- Homo vertebrate TFProf.cgi alpha CETP T05325 alpha sapiens s ?T05325 <T01345> gene [1] NULL for DNA activator binding as a requires heterodim dimerizati er with on with RXR- RXR- alpha alpha, regulator see of the <T05671> physiologi splice cal variants response are to known, xenobiotic human s in a SXR complex <T04610> cross-talk , PXR-2 with CAR <T04641> (NR1I3) forms [8] [6] heterodim regulates ers with physiologi RXR- cal alpha for response DNA to LCA binding (toxic bile and gene acid) http://local activation possibly NR1I2, host/cgi- the in the pregnane bin/biobas crystal cooperatio X e/transfac/ structure n with receptor, human, 7.4/bin/get of LBD in FXR hPAR-1, Homo vertebrate TFProf.cgi complex (NR1H4), T04617 PXR-1 PAR-1. sapiens s ?T04617 with the for NULL for DNA activator binding as a requires heterodim dimerizati er with on with RXR- RXR- alpha alpha, regulator see of the <T05673> physiologi direct cal interaction response of ligand- to binding xenobiotic domain s in a with complex steroid cross-talk ligands with CAR (e.g. (NR1I3) pregnenol [6] one, regulates pregnenol physiologi one cal 16alpha- response carbonitril to LCA e) [1] (toxic bile ligand- acid) http://local dependent possibly host/cgi- in the NR1I2, bin/biobas interaction cooperatio pregnane e/transfac/ of ligand- n with X mouse, 7.4/bin/get binding FXR receptor, Mus vertebrate TFProf.cgi domain (NR1H4) T04618 PXR-1 PXR. musculus s ?T04618 with [4] NULL activator regulator of the xenobiotic response in a complex interplay with CAR:RXR -alpha [3] [1] activates transcripti on in response to steroids, clotrimazo le, heterodim rifampicin er, for provides individual gene polypeptid induction es see by toxic human bile acid http://local PXR-1 LCA [2] host/cgi- <T04617> interacts bin/biobas and efficiently e/transfac/ human and PXR- human, 7.4/bin/get RXR- provides 1:RXR- Homo vertebrate TFProf.cgi alpha gene T05671 alpha sapiens s ?T05671 <T01345> activation NULL activator activates transcripti on in response to steroids and xenobiotic s regulator of liver- specific expressio n of genes encoding enzymes of heterodim xenobiotic er, for individual metabolis polypeptid m [3] [2] es see [4] [1] has mouse been PXR-1 shown to http://local <T04618> bind host/cgi- and different bin/biobas mouse DNA e/transfac/ RXR- elements: PXR- mouse, 7.4/bin/get alpha DR3 [3] 1:RXR- Mus vertebrate TFProf.cgi <T01331> [1], DR4 T05673 alpha musculus s ?T05673 . [2] [1], NULL heterodim er, for individual polypeptid es see http://local human host/cgi- PXR-1 bin/biobas <T04617> e/transfac/ and PXR- human, 7.4/bin/get human 1:RXR- Homo vertebrate TFProf.cgi RXR-beta T05672 beta sapiens s ?T05672 <T01334> NULL smaller range of activating ligands than isoform <T04618> probably due to shorter ligand- binding domain [1] activating ligands: dexameth asone-t- butyl- acetate (artificial http://local ligand), host/cgi- 5beta- NR1I2, bin/biobas 3,20- pregnane e/transfac/ dione X mouse, 7.4/bin/get (naturally receptor, Mus vertebrate TFProf.cgi occuring) T04619 PXR-2 PXR. musculus s ?T04619 [1] NULL activator activates transcripti on in response to steroids and xenobiotic heterodims er, for regulator of liver- individual specific polypeptid es see expressio mouse n of PXR-2 genes http://local <T04619> encoding host/cgi- and enzymes bin/biobas mouse of e/transfac/ RXR- xenobiotic PXR- mouse, 7.4/bin/get alpha 2:RXR- Mus vertebrate TFProf.cgi <T01331> metabolis T05674 alpha musculus s ?T05674 . m [1] NULL two splice variants are http://local known retinoic host/cgi- RAR- acid bin/biobas alpha1 receptor e/transfac/ <T00719> alpha, human, 7.4/bin/get and RAR- RAR- NR1B1, Homo vertebrate TFProf.cgi alpha2 T05299 alpha RARa. sapiens s ?T05299 <T05298> NULL heterodim er for individual polypeptid es see rat binds to http://local RAR- the host/cgi- alpha hormone bin/biobas <T05274> responsiv rat, e/transfac/ and rat e element RAR- Rattus 7.4/bin/get RXR- of HNF- alpha:RX norvegicu vertebrate TFProf.cgi alpha 4alpha T05273 R-alpha s s ?T05273 <T04383> gene [1] NULL heterodim er for individual polypeptid es see human RAR- alpha <T05299> and human RXR- alpha <T01345> heterodim er formation is strictly DNA- dependent [1] RXR activator binds to in the response downstrea to retinoic m half- acid [2] http://local site [1] binds to host/cgi- specific DR1 bin/biobas protein- repeats e/transfac/ DNA [1] binds RAR- human, 7.4/bin/get interaction to DR5 alpha:RX Homo vertebrate TFProf.cgi s are repeats T05300 R-alpha sapiens s ?T05300 more [2] NULL heterodim er for individual polypeptid es see human RAR- http://local alpha host/cgi- <T05299> bin/biobas and e/transfac/ human RAR- human, 7.4/bin/get RXR- alpha:RX Homo vertebrate TFProf.cgi gamma activator T05370 R-gamma sapiens s ?T05370 <T04807> [1] NULL member of the steroid hormone receptor superfamil y negative regulator of AP-1 responsiv e genes, dependent on the DNA- binding domain of RAR and possibly via an unproducti ve complex with c- Jun 1st zinc RAR- http://local finger is alpha, host/cgi- the retinoic bin/biobas determina acid e/transfac/ nt of half- receptor human, 7.4/bin/get site RAR- alpha, Homo vertebrate TFProf.cgi two splice spacing T00719 alpha1 NR1B1. sapiens s ?T00719 variants favouring NULL negative regulation of AP-1 responsiv e genes activator of HOXA1 <T01696> by binding to a3 RAR- http://local enhancer beta, host/cgi- retinoic retinoic bin/biobas 3 N- acid acid e/transfac/ terminally responsiv receptor human, 7.4/bin/get differing e element beta, Homo vertebrate TFProf.cgi splice (RARE) T00721 RAR-beta NR1B2. sapiens s ?T00721 variants [5] NULL member of the steroid hormone receptor superfamil y3 subtypes (alpha, beta, gamma) activator of two N- HOXA1 terminally <T01696> differing by splice binding to variants a3 RAR- http://local (RAR- enhancer gamma, host/cgi- gamma1 retinoic retinoic bin/biobas and - acid acid e/transfac/ gamma2) responsiv receptor human, 7.4/bin/get of 454 e element RAR- gamma, Homo vertebrate TFProf.cgi and 443 (RARE) T00720 gamma NR1B3. sapiens s ?T00720 AA [2] NULL http://local RAR- host/cgi- expressio gamma, bin/biobas n is retinoic e/transfac/ regulated acid mouse, 7.4/bin/get by RAR- receptor Mus vertebrate TFProf.cgi two splice retinoic T01329 gamma gamma. musculus s ?T01329 variants acid NULL binds to natural (embryo:) DNA as a occuring expressed homodime high on r or as a affinity E10.5, heterodim ligand E11.5, er with a (retinoid E12.5, number X) is 9-cis E13.5, of retinoic E14.5, different acid E15.5, nuclear which E16.5, receptors: induces E17.5, RAR- transcacti E18.5 [6]; alpha, - vation E 16.5 (in beta, - activity [6] situ): gamma, responds strong TR-alpha, to a signals in ARP-1, variety of epithelia PPAR- endogeno of alpha, us digestive PPAR- retinoids, system, gamma, but again skin, liver VDR, 9-cis and CAR, retinoic weaker LXR- acid is signals in alpah, most central LXR- potent nervous http://local beta, ligand system, retinoid X host/cgi- FXR, with high skeleton receptor bin/biobas FXRbeta transactiv [6]; alpha, e/transfac/ for ation (adult:) RXR- mouse, 7.4/bin/get heterodim activity liver; RXR- alpha, Mus vertebrate TFProf.cgi ers, see (up to 40- kidney, T01331 alpha NR2B1. musculus s ?T01331 <T05236> fold more lung, member of the steroid hormone receptor superfamil y [3] binds to regulatory element of major histocomp H2RIIBP, atibility retinoid X http://local class I receptor host/cgi- genes beta, bin/biobas and to the RXR- e/transfac/ ER beta, human, 7.4/bin/get response RXRB, Homo vertebrate TFProf.cgi element T01334 RXR-beta NR2B2. sapiens s ?T01334 [3] NULL two mRNA- species exist (2.7 retinoid X kb and receptor 3.0 kb) (adult:) beta, which high RXR- seem to levels in beta, http://local be adrenal, NR2B2, host/cgi- expressed brain, nuclear bin/biobas to heart, receptor rat, e/transfac/ comparabl kidney, co- Rattus 7.4/bin/get e levels in lung, regulator norvegicu vertebrate TFProf.cgi the same muscle, T01349 RXR-beta 1. s s ?T01349 tissues [2] activator spleen [2] provides gene regulation by steroids and xenobiotic s regulates both CYP2B and CYP3A cytochrom e genes in a complex interplay heterodim with er, for CAR:RXR individual [1] is polypeptid able to es see bind DNA human response SXR elements http://local <T04610> of host/cgi- and different bin/biobas human structure: e/transfac/ RXR- ER6 [2], human, 7.4/bin/get alpha DR4 [1], SXR:RXR Homo vertebrate TFProf.cgi <T01345> DR3 [1] in T05670 -alpha sapiens s ?T05670 . several NULL transcripti onal inhibitor [1] BMP-4 and SMAD-1 <T04432> activate Xvent-1 expressio n which mediates supressio n of FOXA4b (XFD-1 ) <T01830> http://local and its host/cgi- restricted bin/biobas expressio clawed e/transfac/ n to the frog, 7.4/bin/get Speman Xenopus vertebrate TFProf.cgi organizer T04665 Xvent-1 laevis s ?T04665 [1] NULL repressor [2] the lower molecular weight population (180-190 kDa) is predomin antly found in embryonic tissues, enhanced in committed myoblasts CloxA is and most chondrocy likely an tes [2] the alternative higher splice molecular product weight of CDP population [2] is http://local human prevalent host/cgi- CDP(1- in adult bin/biobas 878)/dog and e/transfac/ Clox(879- terminally dog, 7.4/bin/get 1505) differentiat CDP, Canis vertebrate TFProf.cgi chimera ed T01485 Clox Cux. canis s ?T01485 [1] tissues [2] NULL data from mediates crystal gene structure, induction CD, NMR /repressio of the n by DBD glucocorti available coids via [11] [6] direct native binding to folding of DNA the DBD glucocorti to full coid alpha- response helix elements content [22] [12] requires ligand zinc ions binding [33] DNA- leads to binding to dissociatio a GRE n from half-site hsp90 is and suppresse allows d by the nuclear A/B translocati region on [5] GR http://local first zinc can act host/cgi- finger through glucocorti bin/biobas binds composite coid rat, e/transfac/ specificall elements receptor, Rattus 7.4/bin/get y to GRE, where it GCR, norvegicu vertebrate TFProf.cgi the cooperate T00333 GR NR3C1. s s ?T00333 second s with NULL http://local host/cgi- glucocorti bin/biobas coid e/transfac/ receptor, chick, 7.4/bin/get GR, Gallus vertebrate TFProf.cgi T00334 GR NR3C1. gallus s ?T00334 NULL the first zinc finger of the DBD binds specificall y to the GRE, the second enhances the affinity [9] essential for GRE/ERE discrimina tion: knuckle of the 1st zinc finger (GS vs. EG) ligand- binding http://local domain host/cgi- (LBD) glucocorti bin/biobas contains coid e/transfac/ a long receptor, mouse, 7.4/bin/get helix, H9, GR, Mus vertebrate TFProf.cgi with 30 T00335 GR NR3C1. musculus s ?T00335 residues, NULL http://local host/cgi- glucocorti bin/biobas coid e/transfac/ receptor, 7.4/bin/get GR, cat, Felis vertebrate TFProf.cgi T00336 GR NR3C1. catus s ?T00336 NULL 2 splice activator variants or alpha repressor <T00337> in and beta response <T01920> to (742 glucocorti AA), coid differing hormones in their C- [17] termini binds [24] the hormone, first zinc translocat finger es into binds the specificall nucleus, y to the and GRE, the activates second transcripti enhances on of the hormone- affinity sensitive [14] gene in AGRND contrast within the to beta second isoform http://local finger <T01920> glucocorti host/cgi- mediates which coid bin/biobas homodime does not receptor, e/transfac/ rization activate GR, human, 7.4/bin/get and known NR3C1, Homo vertebrate TFProf.cgi contribute hormone- T00337 GR-alpha GR alpha. sapiens s ?T00337 s to the sensitive NULL androgen http://local receptor, host/cgi- AR, bin/biobas NR3C4, e/transfac/ dihydrotes mouse, 7.4/bin/get tosterone Mus vertebrate TFProf.cgi T00041 AR receptor. musculus s ?T00041 NULL http://local androgen host/cgi- receptor, bin/biobas NR3C4, baboon, e/transfac/ dihydrotes Papio 7.4/bin/get tosterone hamadrya vertebrate TFProf.cgi T04652 AR receptor. s s ?T04652 NULL http://local androgen host/cgi- receptor, bin/biobas NR3C4, Chimpanz e/transfac/ dihydrotes ee, Pan 7.4/bin/get tosterone troglodyte vertebrate TFProf.cgi T04653 AR receptor. s s ?T04653 NULL http://local androgen host/cgi- receptor, bin/biobas NR3C4, macaque, e/transfac/ dihydrotes Macaca 7.4/bin/get tosterone fasciculari vertebrate TFProf.cgi T04654 AR receptor. s s ?T04654 NULL http://local androgen host/cgi- receptor, bin/biobas NR3C4, lemur, e/transfac/ dihydrotes eulemur 7.4/bin/get tosterone fulvus vertebrate TFProf.cgi T04655 AR receptor. collaris s ?T04655 NULL regions A and C are activator acidic, of pol II region B and pol III Se-Cys http://local is basic promoters tRNA host/cgi- [2] of gene bin/biobas significant several transcripti clawed e/transfac/ similarity small on frog, 7.4/bin/get with RNA activating Xenopus vertebrate TFProf.cgi human genes [2] T02247 Staf factor. laevis s ?T02247 ZNF76 [2] [1] NULL putatively an unusual member of the bZIP family of transcripti on factors strongly homologo us protein sequence and DNA recognitio n site to those of suggested the to factors modulate P3A2 and transcripti ewg [1], on of and metabolic therefore genes also important alpha- assumed for cell PAL, to growth [1] alpha- http://local constitute and of palindrom host/cgi- an own genes e-binding bin/biobas class of encoding protein, e/transfac/ transcripti respiratory nuclear human, 7.4/bin/get on factors chain respiratory Homo vertebrate TFProf.cgi with them subunits T00673 NRF-1 factor 1. sapiens s ?T00673 [2] the [6] [3] NULL http://local activator, host/cgi- regulator bin/biobas of NRF-1, monkey, e/transfac/ nuclear- nuclear Cercopith 7.4/bin/get encoded respiratory ecus vertebrate TFProf.cgi respiratory T01197 NRF-1 factor 1. aethiops s ?T01197 genes NULL activator, stimulatin g cells proliferatio n of somatotro phs, lactotroph s, and thyrothrop hs [2] naturally occurring A158P mutant within helix 1 of POU2 has lost gene activation capability, Pit-1, but still GHF-1, stimulates Pit-1b, pituitary- proliferatio specific http://local n causing positive host/cgi- hypopituit transcripti bin/biobas arism in on factor e/transfac/ homozygo 1, growth human, 7.4/bin/get us hormone Homo vertebrate TFProf.cgi individuals pituitary T00325 POU1F1 factor 1. sapiens s ?T00325 [2] [2] activator, also responsibl e for establish ment and maintenan ce of the differentiat ed phenotype of somatotro phs and for proliferatio n of these cells [4] Pit-1 appearan ce in somatotro Pit-1, phs GHF-1, coincides Pit-1b, with pituitary- growth specific http://local hormone positive host/cgi- expressio transcripti bin/biobas n [6] on factor e/transfac/ triggered 1, growth mouse, 7.4/bin/get by cAMP hormone Mus vertebrate TFProf.cgi to pituitary T01172 POU1F1 factor 1. musculus s ?T01172 activate gland alternativetissue- splicing specific gives rise activator to a 291 [27] [24] AA although protein binding to which is POU1F1 the major sites like form POU1F1b POU1F1a , it trans- makes activates approxima the tely 1/7 ofgrowth all hormone POU1F1 (GH) mRNA in gene, but pituitary not the cells [8] Prl and [6] GHF1 alternativepromoters (in translation contrast initiation to GHF- gives rise 1) due to lactotroph to the 26 AA s, another insertion somatotro http://local product [6] phs and GHF-2, host/cgi- of 31 kDa transcripti thyrotroph LSF-1, bin/biobas [12] both on of the s of Pit-1, rat, e/transfac/ POUs pit-1 gene anterior PUF-1, Rattus 7.4/bin/get and is pituitary PUF-I, Pit- norvegicu vertebrate TFProf.cgi POUh triggered gland [27] T00691 POU1F1a 1a. s s ?T00691 contact by [23] [20] alternative tissue- splicing specific gives rise activator to a 26 [25] [22] AA activates insertion the genes after for position growth 47 hormone leading to (GH), an altered prolactin trans- (Prl) and activation its own domain in (GHF1) Pit- promoter 1a/GHF-2 [5] Pit-1b is transcripti the on of the predomin pit-1 gene ant form is [7] [5] triggered alternative by environme translation ntal lactotroph initiation stimuli s, gives rise that somatotro http://local to enhance phs and host/cgi- another intracellul thyrotroph bin/biobas product ar cAMP s of rat, e/transfac/ of 31 kDa concentrat anterior LSF-1, Rattus 7.4/bin/get [11] both ions [20] pituitary PUF-1, norvegicu vertebrate TFProf.cgi POUs autoregula gland [25] T01516 POU1F1b GHF-1. s s ?T01516 and tion [21] [18] detectable as 6S and 9S form 95 kDa: ligand- binding subunit Stokes radius: 7.1 nm [22] [21] dissociatio n into subunits upon prolonged treatment with 0.4 activator, M KCl binds to sedimenti xenobiotic ng with response AhR, Ah 4.9-5.6 S element receptor, [22] [19] [20] dioxin pI(calc.) = [15] DNA- receptor, 5.98 [10], binding XRE- http://local pI(exp.) = can be binding host/cgi- 5.2-5.7 abolished factor, bin/biobas [14] in by aryl e/transfac/ heterodim phosphata hydrocarb mouse, 7.4/bin/get eric se on Mus vertebrate TFProf.cgi complexe treatment T00018 AhR receptor. musculus s ?T00018 s with [11] NULL 95 kDa: ligand- binding subunit Stokes radius: 7.0 nm dissociatio n into subunits activator, upon binds to treatment xenobiotic with 0.4 response M KCl element sedimenti [7] quickly ng with up- 4.9-5.6 S regulated [13] by aryl faster hydrocarb dissociatio ons (e.g. n than TCDD) murine within 30 AhR, Ah complex min, receptor, [13] down- dioxin interacts regulated receptor, with requiring XRE- http://local hsp90 [9] an highest binding host/cgi- [8] DNA- additional, levels in factor, bin/biobas binding of labile liver, aryl rat, e/transfac/ the factor lower in hydrocarb Rattus 7.4/bin/get heterodim over the thymus, on norvegicu vertebrate TFProf.cgi er with subseque kidney, T00019 AhR receptor. s s ?T00019 Arnt is nt 2 h [1] lung [2] binds to xenobiotic response element dioxin- induced DNA binding and gene induction by AhR is down- regulated by cobalt ions (or hypoxia) heterodim through erization activation with Arnt of HIF- http://local required 1alpha AhR, Ah host/cgi- for DNA- competing receptor, bin/biobas binding for the aryl e/transfac/ [9] [8], dimerizati hydrocarb human, 7.4/bin/get interaction on on Homo vertebrate TFProf.cgi with partner T01795 AhR receptor. sapiens s ?T01795 hsp90 [10] Arnt [5] [4] NULL binds to a xenobiotic response element strongly activated by TCDD and by staurospo rin as ligands [1] induction is not inhibited by PKC inhibitors H7 or calphostin , therefore http://local PKC AhR, Ah host/cgi- seems receptor, bin/biobas not to be aryl e/transfac/ involved hydrocarb guinea 7.4/bin/get in AhR (TCDD- on pig, Cavia vertebrate TFProf.cgi induction induced T02270 AhR receptor. sp. s ?T02270 [1] liver) there is a involved splice in and variant of required 774 AA for Ah <T01796> receptor [9] the binding to PAS XREs [9] domain [8] no reveals ligand some (dioxin) homology binding to strong Drosophil constitutiv a e melanoga activator ster Per [7] and Sim relative [5] in contributio heterodim n of Arnt eric and AhR complexe to overall hypoxia- s with activation inducible either by the factor AhR or AhR/Arnt 1beta, Sim, Arnt complex aryl recognize depend hydrocarb http://local s the 3 - on cell on host/cgi- half-site type and receptor bin/biobas sequence promoter nuclear e/transfac/ GTG [5] context translocat human, 7.4/bin/get both the [7] HIF-1 or, HIF- Homo vertebrate TFProf.cgi HLH and (HIF- T01346 Arnt 1beta. sapiens s ?T01346 the PAS 1alpha/Ar NULL the basic region contacts DNA, the HLH domain mediates dimerizati on [4] the PAS domain reveals some homology to Drosophil a melanoga ster Per and Sim [1] it hypoxia- augments inducible hetero-, factor but not 1beta, homodime aryl rization hydrocarb http://local and is promotes on host/cgi- essential release of receptor bin/biobas for Arnt ligand- nuclear e/transfac/ function complexe translocat mouse, 7.4/bin/get in vivo [4] d AhR or, HIF- Mus vertebrate TFProf.cgi [2] Arnt from T01797 Arnt 1beta. musculus s ?T01797 does not hsp90 [3] (liver) there may be a splice coordinate variant [2] band expressio doublet in n with hypoxia- SDS AhR in inducible PAGE [3] placenta factor significantl at a 1beta, y relatively aryl increases low level hydrocarb http://local DNA- [2] here, on host/cgi- binding the splice receptor bin/biobas by AhR variant is nuclear rat, e/transfac/ by predomin translocat Rattus 7.4/bin/get heterodim antly or, HIF- norvegicu vertebrate TFProf.cgi erization expressed T01798 Arnt 1beta. s s ?T01798 [3] [2] (liver) (embryo:) visceral arches, gut/intesti nes, kidney, phosphory involved lung, lation the in control thymus, basic of CNS, region PNS; proliferatio determine n and very low http://locals its DNA- levels in differentiat host/cgi- binding ion limbs bin/biobas specificityaberrant (late fetal e/transfac/ which is expressio stages), mouse, 7.4/bin/get similar to n may somites Mus vertebrate TFProf.cgi that of c- cause and skin, T01445 N-Myc musculus s ?T01445 Myc [2] [1]neoplasm activator heart [3] [1] may function as a repressor [2] HIF-1 mediates gene responses to lowered oxygen levels (hypoxia, O2 demand exceeds supply) under which HIF-1 state the consists concentrat of two ion of HIF- bHLH 1 is subunits, increased HIF- [4] HIF- http://local 1alpha 1alpha, host/cgi- <T01610> but not bin/biobas and HIF- HIF- e/transfac/ 1beta 1beta, hypoxia- human, 7.4/bin/get (Arnt) needs inducible Homo vertebrate TFProf.cgi <T01346> hypoxia T01609 HIF-1 factor 1. sapiens s ?T01609 [4] for NULL HIF-1 consists of two bHLH subunits, http://local HIF- host/cgi- 1alpha bin/biobas <T04666> e/transfac/ and HIF- hypoxia- mouse, 7.4/bin/get 1beta inducible Mus vertebrate TFProf.cgi (Arnt) T04667 HIF-1 factor 1. musculus s ?T04667 <T01797> NULL http://local host/cgi- heterodim bin/biobas er of HIF- e/transfac/ 1alpha hypoxia- cattle, 7.4/bin/get and HIF- inducible Bos vertebrate TFProf.cgi 1beta T05377 HIF-1 factor 1. taurus s ?T05377 (=Arnt) NULL heterodim http://local er of HIF- host/cgi- 1alpha bin/biobas <T05461> rat, e/transfac/ and HIF- hypoxia- Rattus 7.4/bin/get 1beta inducible norvegicu vertebrate TFProf.cgi (Arnt) T05404 HIF-1 factor 1. s s ?T05404 <T01798> NULL isolated proto- bHLH- oncogene ZIP involved region: in cell mycPp proliferatio bHLH- n control, ZIP may domain induce interacts apoptosis with the may be C- involved terminal in post- part of transcripti AP-2 [17] onal pRb regulation related of rRNA protein metabolis p107 m [27] forms a Myc specific induces complex cyclin A with the and cyclin N- E terminal expressio transactiv n and ation leads to a http://local domain of growth host/cgi- c-Myc in factor- bin/biobas vivo, independe e/transfac/ binding nt human, 7.4/bin/get causes a associatio Homo vertebrate TFProf.cgi significant n of cyclin T00140 c-Myc c-Myc. sapiens s ?T00140 inhibition A with NULL role in cell proliferatio n and differentiat ion of chondrocy tes [3] c- myc gene is involved in the developm ent of B- cell lymphoma s [13] [11] [12] phosphory lation may enhance trans- http://local activation host/cgi- and may differentiat bin/biobas down- ing and e/transfac/ regulate proliferatin chick, 7.4/bin/get transform g Gallus vertebrate TFProf.cgi ation chondrocy T00141 c-Myc c-Myc. gallus s ?T00141 activity [1] tes [3] participate s in the Myc proto- regulation oncogene of gene protein [6] transcripti efficient on of DNA growth- binding related requires genes [6] dimerizati role in on with cell another proliferatio bHLH n and protein differentiat binds ion of DNA as chondrocy an tes [4] heterodim induces er with apoptosis Max in the binds absence DNA both of certain in a non- growth specific factors [3] manner positively and also regulates http://local specificall the genes host/cgi- y to for differentiat bin/biobas recognize translation ing and rat, e/transfac/ s the core initiation proliferatin Rattus 7.4/bin/get sequence factors g norvegicu vertebrate TFProf.cgi CAC(GA) eIF-4E chondrocy T00142 c-Myc c-Myc. s s ?T00142 TG [6] and - tes [4] c-myc proto- oncogene nuclear protein glycoprote in transcripti efficient onal DNA regulator binding activator requires [12] dimerizati forced on with overexpre another ssion of c- bHLH Myc in protein lens fiber http://local binds cells host/cgi- DNA as causes bin/biobas an inappropri e/transfac/ heterodim ate cell mouse, 7.4/bin/get er with cycle Mus vertebrate TFProf.cgi Max [12] progressio T00143 c-Myc c-Myc. musculus s ?T00143 [13] n [3] NULL several enhances splice c-Myc variants DNA- <T00489> binding in , high <T01567> concentrat detected ions: Max homodime homodime rs rs and suppress Myc/Max c-Myc heterodim activities ers by exhibit competitio different n [13] [16] preferenc [6] after es for the CKII trinucleoti phosphory des lation, flanking increases the core in on- and sequence off-rates (CACGTG of DNA- ) [5] binding of Max1 and homo- Max2 and http://local also differ heterodim host/cgi- slightly in ers have bin/biobas their DNA- been e/transfac/ binding found [8] Max, Myn human, 7.4/bin/get specificity preferenti (mouse), Homo vertebrate TFProf.cgi [5] [12] ally T00489 Max1 p21. sapiens s ?T00489 heterodim complexe NULL solution of the crystal structure revealed that the HLH enhances motifs c-Myc form a DNA- four-helix- binding, bundle perturbati with all on of helices in homodime parallel r-binding orientation after CKII [5] helix phosphory 2 is lation, but prolonged not of by the Myc/Max- alpha- heterodim newborn: helically er [6] in intestine, folded complexe weak in leucine s with brain, zipper either liver, heterodim Mxi1 or lung; ers with c- Mad, it adult: http://local Myc or represses very host/cgi- Mad have c-Myc or strong in Myn, Myc- bin/biobas higher N-Myc intestine, binding e/transfac/ DNA- effects [4] weak in novel mouse, 7.4/bin/get binding murine brain, HLH/LZ Mus vertebrate TFProf.cgi affinity [9] homolog kidney, T00523 Max protein. musculus s ?T00523 the of MAX [9] lung [3] activates several intestine- specific promoters [4] [3] activates liver- specific promoters [6] [1] nuclear previously http://local activity, known AF-1, host/cgi- may be as AF-1 HNF4, bin/biobas composed binding to hepatocyt e/transfac/ of HNF- apolipopro e nuclear human, 7.4/bin/get 4alpha, tein factor 4, Homo vertebrate TFProf.cgi HNF- promoters T02758 HNF-4 NR2A1. sapiens s ?T02758 4gamma. [6] NULL two isoforms (at least for human and mouse) encoded by two different genes are known: HNF- 4alpha and HNF- 4gamma for HNF-4 alpha <T05288> two splice variants are known: http://local HNF- host/cgi- 4alpha1 activator bin/biobas <T00372> activates rat, e/transfac/ , HNF- genes in Rattus 7.4/bin/get 4alpha2 liver, (rat liver norvegicu vertebrate TFProf.cgi <T02422> kidney, nuclear T05017 HNF-4 AF-1. s s ?T05017 . intestine. extracts) http://local host/cgi- bin/biobas activator chipmunk, e/transfac/ of Tamias 7.4/bin/get hibernatio asiaticus vertebrate TFProf.cgi n-specific T05294 HNF-4 HNF4. (sibiricus) s ?T05294 gene [1] liver forms activator homodime of genes rs involved alternative in splice glucose variants transport of HNF- and 4alpha: metabolis HNF- m: 4alpha1 glucose <T02421> transporte , HNF- r 2, 4alpha2 aldolase <T00373> B, , HNF- glyceralde 4alpha3 hyde-3- <T02428> phosphate and HNF- 4alpha4 dehydroge <T02425> nase and an liver additional pyruvate exon 1C kinase [6] has been controls pancreas, described the kidney, [5] expressio liver, HNF4, http://local interacts n of the small HNF-4, host/cgi- with co- liver intestine, hepatocyt bin/biobas activator specific colon, e nuclear e/transfac/ PGC-1 transcripti testis factor 4, human, 7.4/bin/get through on factor (barely HNF- HNF-4A, Homo vertebrate TFProf.cgi AF-2 HNF-1A detectable T03828 4alpha NR2A1. sapiens s ?T03828 domain [1] <T00368> ) [9] forms homodime rs at least 3 splice variants are known: HNF- 4alpha1 http://local <T02424> host/cgi- , HNF- bin/biobas 4alpha2 AF-1, e/transfac/ <T02423> activator HNF4, mouse, 7.4/bin/get , HNF- of liver- HNF- NR2A1, Mus vertebrate TFProf.cgi 4alpha7 specific T05287 4alpha HNF4A. musculus s ?T05287 <T02427> genes [1] NULL forms homodime rs activator exclusivel of liver- y, does specific not form genes heterodim first, ers with identified RARs, as a RXR- nuclear alpha, activity ARP-1, AF-1 TR-alpha, activating VDR [4] apolipopro at least tein two splice genes [8] variants [6] [7] can are functionall known: y HNF- cooperate 4alpha1 with <T00372> SMAD- , HNF- 3/SMAD- 4alpha2 4 and <T02422> thus located participate http://local exclusivel in host/cgi- y in the TGFbeta bin/biobas nucleus induction rat, e/transfac/ [4] of the Rattus 7.4/bin/get nuclear ApoC3 HNF- norvegicu vertebrate TFProf.cgi localizatio promoter T05288 4alpha AF-1. s s ?T05288 n and [2] NULL the HNF4, originally HNF-4, published hepatocyt 455-AA e nuclear sequence factor 4, http://local may lack hepatocyt host/cgi- an e nuclear bin/biobas authentic factor e/transfac/ N- 4alpha1, human, 7.4/bin/get terminal HNF- HNF-4A, Homo vertebrate TFProf.cgi 9-AA T02421 4alpha1 NR2A1. sapiens s ?T02421 stretch [2] NULL (embryoni c) visceral extraembr yonic endoderm (d 7-10 pc), in the periphery of the liver (d 11.5-16 pc), meso- and metaneph ros of the kidney (d HNF4, 10.5- HNF-4, birth) [4]; hepatocyt (adult) e nuclear http://local kidney, factor 4, host/cgi- liver, hepatocyt bin/biobas stomach, e nuclear e/transfac/ low in factor mouse, 7.4/bin/get intestine HNF- 4alpha1, Mus vertebrate TFProf.cgi [1], skin T02424 4alpha1 NR2A1. musculus s ?T02424 [4] transcripti onal activator http://local may be host/cgi- antagoniz hepatocyt bin/biobas ed by e nuclear rat, e/transfac/ ARP-1 factor Rattus 7.4/bin/get and/or liver, HNF- 4alpha2, norvegicu vertebrate TFProf.cgi COUP- kidney, T02422 4alpha2 NR2A1. s s ?T02422 TF [1] intestine http://local host/cgi- hepatocyt bin/biobas e nuclear e/transfac/ factor mouse, 7.4/bin/get HNF- 4alpha2, Mus vertebrate TFProf.cgi T02423 4alpha2 NR2A1. musculus s ?T02423 NULL the published activator, sequence similar http://local may lack trans- hepatocyt host/cgi- an activation e nuclear bin/biobas additional capability factor e/transfac/ N- as HNF- 4alpha3, human, 7.4/bin/get terminal 4alpha1 HNF- HNF-4C, Homo vertebrate TFProf.cgi 9-AA and - T02428 4alpha3 NR2A1. sapiens s ?T02428 stretch [2] alpha2 [3] NULL http://local host/cgi- hepatocyt bin/biobas e nuclear e/transfac/ factor human, 7.4/bin/get HNF- 4alpha4, Homo vertebrate TFProf.cgi activator T02425 4alpha4 NR2A1. sapiens s ?T02425 [1] NULL dedifferen tiated hepatic cells, (adult:) activator, stomach, significantl liver, hepatocyt http://local y lower intestine, e nuclear host/cgi- trans- very low factor bin/biobas activation in 4alpha7, e/transfac/ than by bladder, NR2A1, mouse, 7.4/bin/get incomplet HNF- brain, HNF- HNF- Mus vertebrate TFProf.cgi e C- 4alpha1 heart, T02427 4alpha7 4alphaP2. musculus s ?T02427 terminus [1] ovary, [1] results from transcripti on from the alternative promoter P2 and splicing exon P2 to exon 2 removing a fragment of 50.205 Kb from the human HNF- 4alpha gene [1] for alternative splice variants see HNF- http://local 4alpha1 host/cgi- <T02421> bin/biobas , HNF- e/transfac/ 4alpha2 human, 7.4/bin/get <T00373> HNF- HNF- Homo vertebrate TFProf.cgi , HNF- T05285 4alpha7 4alphaP2. sapiens s ?T05285 4alpha3 NULL kidney, http://local pancreas, hepatocyt host/cgi- small e nuclear bin/biobas intestine, factor e/transfac/ testis, 4gamma, human, 7.4/bin/get very low HNF- HNF4G, Homo vertebrate TFProf.cgi activator in colon T02430 4gamma NR2A2. sapiens s ?T02430 [3] [3] cDNA clone (ORF of >218 AA) was supposed to be partial [4], but genomic clones suggest a protein of C/EBPga 150 AA mma, http://local (16.4 GPE1- host/cgi- kDa) [3] ubiquitous BP, bin/biobas no Ig/EBP1, e/transfac/ heterodim transcripti (macroph muEBP- mouse, 7.4/bin/get ers with onal ages, C/EBPga E, Ig/EBP- Mus vertebrate TFProf.cgi DBP [1] activator early B T00216 mma 1. musculus s ?T00216 [4] [6] [9] cells) [2] activator preferenti [4] al synergistic heterodim ally erization cooperate http://local with s with NF- host/cgi- CREB- kappaB, bin/biobas 2/ATF-4, presumabl rat, e/transfac/ no y by Rattus 7.4/bin/get heterodim physical C/EBPga norvegicu vertebrate TFProf.cgi ers with interaction ubiquitous T02028 mma s s ?T02028 DBP [1] [2] [3] http://local host/cgi- CCAAT/e bin/biobas nhancer e/transfac/ binding human, 7.4/bin/get C/EBPga protein- Homo vertebrate TFProf.cgi T04884 mma gamma. sapiens s ?T04884 NULL the N- terminal part of the molecule does not exhibit significant homolgy with other members of the NF- NF-E2- E2 family related [3] DNA- factor 2, http://local binding nuclear host/cgi- as factor, bin/biobas heterodim erythroid e/transfac/ er with derived 2, human, 7.4/bin/get small Maf like 2, Homo vertebrate TFProf.cgi proteins T01443 Nrf2 NFE2L2. sapiens s ?T01443 [1] NULL important (embryoni for c:) (in transcripti situ:) onal expressed belongs induction at E7, to the of E11, E15, CNC antioxidan E17 [1]; (Cap´n´col t E15.5 (in lar) enzymes situ): domain and highest containing phase II level in drug digestive subfamily metabolizi tract and of bZIP ng also high transriptio enzymes levels in n factors through liver, and has ARE lung, high (antioxida kidney sequence nt [1]; NF-E2 similarity response expressed related to element/el in central factor 2, subfamily ectrophile nervous NFE2- members response system related p45- element) (lateral factor 2, NFE2, (compare ventricle, nuclear NRF1, to [3]) no choroid factor, http://local and detectable plexus), erythroid host/cgi- NRF2 [1] effect of stomach, derived 2, bin/biobas forms targeted brown fat like 2, e/transfac/ heterodim disruption tissue [1] NFE2L2, mouse, 7.4/bin/get er with of gene (adult:) NRF2, Mus vertebrate TFProf.cgi MafK function heart, T04938 Nrf2 NRF-2. musculus s ?T04938 <T05576> (homozyg spleen, NFE2- related factor 2, http://local nuclear host/cgi- factor, bin/biobas erythroid rat, e/transfac/ derived 2, Rattus 7.4/bin/get like 2, norvegicu vertebrate TFProf.cgi T05668 Nrf2 NFE2L2. s s ?T05668 NULL http://local host/cgi- heterodim bin/biobas er of Nrf2 e/transfac/ <T04938> mouse, 7.4/bin/get and Mus vertebrate TFProf.cgi MafK T05576 Nrf2:MafK musculus s ?T05576 <T01435> NULL Nrf2 shows DNA- http://local binding host/cgi- as bin/biobas heterodim rat, e/transfac/ er with Rattus 7.4/bin/get MafK, but norvegicu vertebrate TFProf.cgi not alone T05666 Nrf2:MafK s s ?T05666 [1] NULL no PKA or PKC phosphory lation sites [4] in contrast to other ATF repressor factors, it [4] mRNA does not decreases interact with p50 temporaril or p65 y after subunit of raising NFkappa the cAMP B [3] concentrat interacts ion, but with increases latency- with ATF-4, associate enhanced CREB-2, d nuclear calcium TAXREB6 antigen concentrat 7 (LANA ion [6] homolog, <T04852> interaction YAVREB6 http://local ) of with 7, TR67, host/cgi- Kaposi s LANA C/ATF, bin/biobas sarcoma- <T04852> activating e/transfac/ assoziate inhibits transcripti human, 7.4/bin/get d transactiv on factor Homo vertebrate TFProf.cgi herpesviru ation T01303 ATF4 4. sapiens s ?T01303 s [1] ability [1] ubiquitous ATF-4, CREB-2, TAXREB6 7 homolog, YAVREB6 isoform 7, TR67, http://local ATF (381 C/ATF, host/cgi- AA) mTR67, bin/biobas <T02052> activating e/transfac/ by transcripti transcripti mouse, 7.4/bin/get alternative onal on factor Mus vertebrate TFProf.cgi initiation activator T04854 ATF4 4. musculus s ?T04854 site [1] NULL ATF-4, CREB-2, TAXREB6 7 homolog, YAVREB6 7, TR67, http://local isoform C/ATF, host/cgi- ATF mTR67, bin/biobas <T04854> activating e/transfac/ by transcripti transcripti mouse, 7.4/bin/get alternative onal ATF4 on factor Mus vertebrate TFProf.cgi initiation activator T02052 (381AA) 4. musculus s ?T02052 site [1] ubiquitous DNA potent binding activator affinity of when the bound in monomer: the right KD = 1 context, nM [24] e. g. with contacts an DNA from adjacently one side binding [24] and TCF-2 induces a [17] bent of activator, about possibly 117-130 by degree augmentin pre-B [21] [14] g an cells, T widens optimal lymphocyt and binds chromatin es [22]; the minor architectur during groove of e [21] embryoge DNA [21] which nesis: [14] the L- facilitates neural shape other crest, HMG factors to mesencep domain assemble halon, http://local also to a tooth LEF 1, host/cgi- binds transcripti germs, LEF-1L, bin/biobas across on whisker lymphoid e/transfac/ the complex follicles enhancer mouse, 7.4/bin/get narrowed [13] for [16]; s. binding Mus vertebrate TFProf.cgi major expressio global T00930 LEF-1 factor 1. musculus s ?T00930 groove n in teeth, field the LEF-1 contents gene (52 a potent kb) is transcripti located onal on activation chromoso domain me 4 [1], which exon mediates structure: context- 1,2,3, 3a, specific 3b, activation 4,5,6,7,8,9 of the ,10,11,12 TCFalpha [1] enhancer sequence- [17] can specific form a DNA- complex binding is with beta- mediated catenin by the (in the disordere nucleus) lymphoid d N- and thus enhancer terminal activates binding part of gene factor 1, the L- transcripti lymphoid shaped on enhancing http://local HMG member factor 1, host/cgi- domain of the human bin/biobas and by its Wnt- LEF-1, e/transfac/ third /Wingless TCF- human, 7.4/bin/get alpha- -signal 1alpha, Homo vertebrate TFProf.cgi helix [16] transducti T-cells; T02905 LEF-1 hLEF-1. sapiens s ?T02905 binds to on thymus heterodim er for individual polypeptid es see rat USF-1 <T00875> and rat USF-2 <T02115> previously known nuclear activator activity of http://local CIIIB1 apolipopro host/cgi- was tein bin/biobas identified genes rat, e/transfac/ with USF- apoCIII Rattus 7.4/bin/get 1/USF-2 and USF- norvegicu vertebrate TFProf.cgi heterodim apoAII [3] T05262 1:USF-2 CIIIB1. s s ?T05262 ers [2] [2] [1] NULL USF II, USF44, http://local FIP, Fos- host/cgi- interacting bin/biobas constant protein, rat, e/transfac/ levels in upstream Rattus 7.4/bin/get fasted stimulator norvegicu vertebrate TFProf.cgi and refed T02115 USF2 y factor 2. s s ?T02115 rats [1] ubiquitous p50 <T00389> homodime r or p50/p65 http://local heterodim NF- host/cgi- er kappaB, bin/biobas <T00389> NF- rat, e/transfac/ kappaB Rattus 7.4/bin/get <T05016> NF- complex, norvegicu vertebrate TFProf.cgi (or T00587 kappaB p50/p65. s s ?T00587 similar) NULL constituen t complexe s may be p50 <T01923> homodime rs or heterodim ers of p50/p65 <T01923> inducible activator, <T00595> induced , by many p50/RelB agents: e. <T01923> g. TNF [17], PKA- http://local <T01932> or PKC- NF- host/cgi- , or p50/c- mediated kappaB, bin/biobas Rel signals, NF- e/transfac/ <T01923> dsRNA kappaB mouse, 7.4/bin/get [31] [26] NF- complex, Mus vertebrate TFProf.cgi <T00169> [22] [13] T00588 kappaB p50/p65. musculus s ?T00588 [7] [6] [3] [4] [5] NULL inducible activator, induced by many agents: e. described g., TNF as DNA- [24], PKA- binding or PKC- activity, mediated constitute signals, d either dsRNA by a p50 [52] [41] homodime [32] [17] r [37] [9] <T00593> heterodim ,a ers p50/p65 p50/p65 heterodim are er inducible <T00593> by neuropepti <T00594> de (or Substanc related e P and componen this ts), or a induction http://local heterotetr depends NF- host/cgi- amer on kappaB, bin/biobas Zn2+- intracellul NF- e/transfac/ dependent ar Ca2+ kappaB human, 7.4/bin/get DNA- mobilizatio NF- complex, Homo vertebrate TFProf.cgi binding n [1] key T00590 kappaB p50/p65. sapiens s ?T00590 [16] regulator ubiquitous isolated http://local from host/cgi- nuclear bin/biobas extracts rabbit, e/transfac/ from Oryctolag 7.4/bin/get rabbit NF- us vertebrate TFProf.cgi liver and T05148 kappaB p50/p65. cuniculus s ?T05148 kidney NULL http://local host/cgi- bin/biobas e/transfac/ NF- NF- human, 7.4/bin/get kappaB(- kappaB(- Homo vertebrate TFProf.cgi T00591 like) like). sapiens s ?T00591 NULL http://local host/cgi- bin/biobas e/transfac/ NF- NF- mouse, 7.4/bin/get kappaB(- kappaB(- Mus vertebrate TFProf.cgi T00592 like) like). musculus s ?T00592 NULL constitutiv ely expressed synthesize d as a precursor <T01926> binds to DNA as http://local homo- or host/cgi- heteromer bin/biobas implicated rat, e/transfac/ <T00587> in MHC Rattus 7.4/bin/get 2 zinc class II NF- H2TF1, norvegicu vertebrate TFProf.cgi finger expressio T00389 kappaB1 KBF1. s s ?T00389 motifs n NULL N- primary terminal DNA- half of a binding 105 kDa subunit of precursor NF- <T01925> kappaB [36] homodime binds to rs may DNA repress either as transcripti homo- or on [19] heteromer [23] [13] hyperposp <T00590> horylation with in the RelA/p65 cytosol of <T00594> T cells by [32] Cys- a 43 kDa 62 is part protein of a kinase 243/NFA- R(F/G)(R/ which is kappaB, K)YXCE associate EBP-1, motif d with the H2TF1, found in NF- HeLa B also other kappaB/Ik factor, Rel appaB KBF1, http://local proteins complex NF- host/cgi- as well as [3] [6] kappaB bin/biobas in zinc phosphory (p50), NF- e/transfac/ finger lation of kappaB1, human, 7.4/bin/get proteins p50 may NF- p110, TC- Homo vertebrate TFProf.cgi that bind contribute T00593 kappaB1 IIB. sapiens s ?T00593 to to NF- ubiquitous synthesizetranscripti d as a onally 105 kDa inert DNA- precursor binding <T01924> subunit of from holo-NF- which the kappaB N- <T00588> terminal trans- half activating comprisin induced g the Rel heterodim domain is es with released RelA/p65 as <T00595> mature [7] or p50 by with Bcl-3 [5] at proteolytic clipping some [13] bindselements, to DNA however, as homo- p50 may or exert a heteromer constitutiv 243/NFA- e kappaB, <T00588> activating EBP-1, http://local with, e. function H2TF1, host/cgi- g., [8] bound KBF1, bin/biobas RelA/p65 to this NF- e/transfac/ or c-Rel sequence, kappaB mouse, 7.4/bin/get [4] the p50 NF- (p50), Mus vertebrate TFProf.cgi DNA- adopts a T01923 kappaB1 p50. musculus s ?T01923 binding chymotryp ubiquitous transcripti onally inert precursor form, exclusivel y found in the precursor cytoplasm of the NF- kappaB alternative p50 splice <T01923> variants subunit NF- [2] kappaB alternative (p98) and splicing NF- leads to kappaB NF- (p84) are kappaB found (p98) and also in NF- the kappaB nucleus (p84), the [1] only KBF1, latter NF- p110, http://local lacking kappaB p105, NF- host/cgi- most of (p98) can kappaB1 bin/biobas the C- act as a (p105), e/transfac/ terminal transcripti NF- NF- mouse, 7.4/bin/get ankyrin onal kappaB1 kappaB1 Mus vertebrate TFProf.cgi repeats activator T01924 precursor (p110). musculus s ?T01924 [1] [1] ubiquitous 105 kDa inducible precursor by a of the variety of mature inducers transcripti C- on factor terminal NF- sequence kappaB s p50 comprisin subunit g the <T00593> ankyrin [18] the repeats precursor can act interacts as with IkappaB- processed like p50 inhibitor: through IkappaB- its gamma ankyrin [7] repeats nuclear and translocati inhibits its on of p50 nuclear or p65 translocati may be KBF1, on [4] by controlled p110, http://local masking by p105, NF- host/cgi- the NLS heterodim kappaB1 bin/biobas signal erization (p110), e/transfac/ intra- and with the NF- NF- human, 7.4/bin/get intermolec p105 kappaB1 kappaB1 Homo vertebrate TFProf.cgi ularly [5] precursor T01925 precursor (p105). sapiens s ?T01925 this [4] ubiquitous KBF1, p110, http://local p105, NF- host/cgi- kappaB1 bin/biobas (p105), rat, e/transfac/ precursor NF- NF- Rattus 7.4/bin/get of NF- kappaB1 kappaB1 norvegicu vertebrate TFProf.cgi kappeB1 T01926 precursor (p110). s s ?T01926 <T00389> ubiquitous constitutiv e activator when heterodim erized with RelB [4] transcripti onally inert DNA- binding homodime r forms trans- activating ternary complexe s with Bcl- 3 [5] [1] N- the terminal NFKB2 half of a gene 100-kDa contains precursor two <T01927> promoters http://local from [3] at Lyt-10, host/cgi- which it is least four NF- bin/biobas released kappaB kappaB2, e/transfac/ by sites p52, NF- human, 7.4/bin/get proteolytic mediate NF- kappaB2 Homo vertebrate TFProf.cgi clipping positive T00394 kappaB2 (p52). sapiens s ?T00394 [7] autoregula ubiquitous activator when present as heterodim er with RelA (p65) through certain the kappaB homodime sites r binds to (such as a kappaB GGGGAC site (of TTTCC), HIV-1 but LTR) with inactive KD = at others 69.1 pM, (e. g., i. e. with GGGAAT 6-fold CCC of lower MHC H-2 affinity genes) than despite p49/p65 higher heterodim binding http://local ers (KD= affinity [1] host/cgi- 11.8 pM), [2] the bin/biobas and even p49/p65 e/transfac/ less than heterodim NF- human, 7.4/bin/get p50 er is kappaB2 Homo vertebrate TFProf.cgi homodime under T01930 (p49) p49. sapiens s ?T01930 rs [1] negative ubiquitous heterodim ers with RelB or c- Rel are retained in the cytoplasm unless an appropriat e DNA- stimulus binding causes precursor phosphory of mature lation and NF- proteolytic kappaB2 H2TF1, (p52) [3] processin p100, [2] KD for g of the p97, binding to precursor p98/p55, http://local a kappaB with NF- host/cgi- site is 30 concomita kappaB2 bin/biobas pM [2] an nt NF- (p100), e/transfac/ alternative kappaB2 NF- NF- human, 7.4/bin/get splice (p52) kappaB2 kappaB2 Homo vertebrate TFProf.cgi variant is release T01927 precursor (p97). sapiens s ?T01927 p49 [6] [3] [4] [1] ubiquitous H2TF1, p100, p97, p98/p55, http://local NF- host/cgi- kappaB2 bin/biobas (p100), e/transfac/ NF- NF- chick, 7.4/bin/get different kappaB2 kappaB2 Gallus vertebrate TFProf.cgi sequence T01929 precursor (p97). gallus s ?T01929 in Ref. [1] NULL http://local induced host/cgi- by tumor NF- bin/biobas necrosis kappaB- e/transfac/ factor like mouse, 7.4/bin/get alpha factor, Mus vertebrate TFProf.cgi (TNF- T00606 NF-TNF NF-TNF. musculus s ?T00606 alpha) NULL http://local induced host/cgi- by tumor NF- bin/biobas necrosis kappaB- rat, e/transfac/ factor like Rattus 7.4/bin/get alpha factor, norvegicu vertebrate TFProf.cgi (TNF- T01224 NF-TNF NF-TNF. s s ?T01224 four AA activator NULL alpha) residues contribute in the s the DNA- major binding transcripti Rel on domain activation mediate a domain to distinct the NF- DNA- kappaB binding <T00590> specificity complex of the [26] at RelA some (p65) sequence homodime s, its r homodime compared rs may to act as heterodim transcripti ers [14] onal cytoplasmi activators c [25] [28] inhibitors synergistic (IkappaB- effects alpha and with AP-1 http://local -beta) through host/cgi- bind to AP-1 NF- bin/biobas the Rel sites as kappaB e/transfac/ domain of well as (p65), human, 7.4/bin/get RelA [31] through Rel-A, Homo vertebrate TFProf.cgi [30] thus kappaB T00594 RelA p65. sapiens s ?T00594 masking sites (c- ubiquitous the Rel the domain heterodim constitute er with s the p50 DNA- avidly contacting binds to domain asymmetri either in c DNA- homo- or sequence in s at some heterodim sequence ers [7] s, its the homodime affinity of rs may the act as homodime transcripti r to onal kappaB activators sites is 4- [7] target fold to 13- for the fold lower cytoplasmi than that c inhibitor of IkappaB p50/p65 [10] [8] heterodim RelA ers establishe http://local <T00588> s an host/cgi- [5] autoregua NF- bin/biobas cytoplasmi tory loop kappaB e/transfac/ c by (p65), mouse, 7.4/bin/get inhibitors activating Rel-A, Mus vertebrate TFProf.cgi (IkappaB- the T00595 RelA p65. musculus s ?T00595 alpha and IkappaB- ubiquitous http://local host/cgi- NF- bin/biobas kappaB rat, e/transfac/ constituen (p65), Rattus 7.4/bin/get t of NF- Rel-A, norvegicu vertebrate TFProf.cgi kappaB T05016 RelA p65. s s ?T05016 <T00587> NULL conserved required C- for terminal transcripti part, 88% on by identity polymeras with e I, II, and Drosophil III [31] a and basal 80% transcripti identity on by pol with yeast II is TBP [48] mediated [42] some by TBP, homology upstream with activator bacterial effects by IHFs with TBP- the two TAF(II) direct complexe repeats s (TFIID) within the alone conserved functional part [39] on TATA- the containing divergent pol III N- promoters http://local terminal , on TBP, host/cgi- part is TATA- TFIID, bin/biobas required less pol TFIIDtau, e/transfac/ for TATA- III TATA- human, 7.4/bin/get containing promoters binding Homo vertebrate TFProf.cgi pol II and only as B- T00794 TBP protein. sapiens s ?T00794 pol III TFIID ubiquitous http://local TBP, host/cgi- TFIID, bin/biobas is part of TFIIDtau, e/transfac/ TFIID TATA- mouse, 7.4/bin/get binds to binding Mus vertebrate TFProf.cgi DNA as a T00796 TBP protein. musculus s ?T00796 monomer ubiquitous TATA- compositi box- http://local on: TBP binding host/cgi- + TAF- complex bin/biobas 250 + of TBP e/transfac/ TAF-125 and TAFs dTFIID, human, 7.4/bin/get + TAF-95 can be TAB, Homo vertebrate TFProf.cgi + TAF-78 competed T00820 TFIID TFIID. sapiens s ?T00820 + TAF-50 by En NULL http://local host/cgi- bin/biobas e/transfac/ chick, 7.4/bin/get Gallus vertebrate TFProf.cgi T00821 TFIID TFIID. gallus s ?T00821 NULL http://local host/cgi- bin/biobas e/transfac/ mouse, 7.4/bin/get Mus vertebrate TFProf.cgi T01159 TFIID TFIID. musculus s ?T01159 NULL http://local host/cgi- bin/biobas rat, e/transfac/ Rattus 7.4/bin/get norvegicu vertebrate TFProf.cgi T01175 TFIID TFIID. s s ?T01175 NULL HNF4, activator HNF-4, [2] hepatocyt maternally e nuclear http://local provided, factor 4, host/cgi- forming hepatocyt bin/biobas an animal e nuclear clawed e/transfac/ to vegetal factor frog, 7.4/bin/get gradient HNF- 4alpha1, Xenopus vertebrate TFProf.cgi in the T02429 4alpha1 NR2A1. laevis s ?T02429 embryo [2] NULL COUP, COUP- TF, chicken http://local ovalbumin host/cgi- bin/biobas upstream e/transfac/ promoter chick, 7.4/bin/get transcripti Gallus vertebrate TFProf.cgi T00148 COUP on factor. gallus s ?T00148 NULL http://local host/cgi- bin/biobas e/transfac/ 7.4/bin/get NF-1, NF- cat, Felis vertebrate TFProf.cgi T00533 NF-1 I. catus s ?T00533 NULL http://local host/cgi- bin/biobas monkey, e/transfac/ Cercopith 7.4/bin/get CTF, NF- ecus vertebrate TFProf.cgi T00534 NF-1 1, NF-I. aethiops s ?T00534 NULL http://local CTF, NF- host/cgi- 1, NF-I, bin/biobas TGGCA- rat, e/transfac/ binding Rattus 7.4/bin/get O- protein norvegicu vertebrate TFProf.cgi glycosylati T00535 NF-1 (chick). s s ?T00535 on NULL http://local host/cgi- bin/biobas e/transfac/ clawed 7.4/bin/get CTF, NF- frog, vertebrate TFProf.cgi T00536 NF-1 1, NF-I. Xenopus s ?T00536 (oocytes) nuclear activity presently, 4 different genes encoding NF- 1/CTF factors in CCAAT- mouse binding are factor, known: CCAAT NFIA, box- NFIB binding <G005252 transcripti >, NFIC, on factor, NFIX CTF, NF- NFIB 1, NF-1 (- gene like produces proteins), several NF-1-like, splice NF-I, variants, TGGCA- see binding entries: protein, http://local NF1-B2 CCAAT- host/cgi- <T01909> box bin/biobas , NF1-B3 binding e/transfac/ <T01910> transcripti mouse, 7.4/bin/get , NF1-B4 on factor, Mus vertebrate TFProf.cgi <T01911> T00537 NF-1 ctf/nf-1. musculus s ?T00537 O- NULL http://local host/cgi- CTF, NF- bin/biobas 1, NF-I, e/transfac/ TGGCA- domestic 7.4/bin/get binding pig, Sus vertebrate TFProf.cgi T00538 NF-1 protein. scrofa s ?T00538 NULL 6 splice variants are known: NF-1 (this entry), CTF-1 <T00176> , CTF-2 <T00177> , CTF-3 CTF, NF- <T00178> 1, NF-I, http://local , CTF-5 TGGCA- host/cgi- <T02300> binding bin/biobas , CTF-7 protein, e/transfac/ <T02301> NFIC1, human, 7.4/bin/get [2] [1] O- NFIC Homo vertebrate TFProf.cgi glycosylati T00539 NF-1 isoform 1. sapiens s ?T00539 on NULL http://local host/cgi- CTF, NF- bin/biobas 1, NF-I, e/transfac/ TGGCA- 7.4/bin/get binding vertebrate TFProf.cgi T01036 NF-1 protein. hamster s ?T01036 NULL http://local host/cgi- bin/biobas e/transfac/ 7.4/bin/get NF-1, NF- sheep, vertebrate TFProf.cgi T01298 NF-1 I. Ovis aries s ?T01298 NULL both subdomai ns of the DBD, the outer N- terminal part (unspecifi cally binding to DNA) and the C- terminal part of the DNA- binding domain (low- affinity, but specific binding), have to cooperate for specific NF1/L, http://local and high- RPF-A host/cgi- affinity (hamster), bin/biobas binding to NF- rat, e/transfac/ DNA [1] activator 1A1.1 Rattus 7.4/bin/get the N- of (chick), norvegicu vertebrate TFProf.cgi terminal replication T00599 NF-1/L NF-I/L. s s ?T00599 subdomai [1] (liver) may act as a repressor http://local (e.g. on NF-1B1 host/cgi- the (chick), bin/biobas proenkep NF- e/transfac/ halin 1/Red1, 7.4/bin/get upon NF- NFI-B1, vertebrate TFProf.cgi cotransfec T00604 1/Red1 RPF-B. hamster s ?T00604 tion) NULL six splice variants encoded http://local by the NF- host/cgi- 1A gene bin/biobas are NF-1A1, e/transfac/ known: NFI-A1, chick, 7.4/bin/get A1, A1.1, RPF-A Gallus vertebrate TFProf.cgi A3, A4, T00544 NF-1A1 (hamster). gallus s ?T00544 A5, A6 [1] NULL http://local NF-1B1, host/cgi- NF- bin/biobas 1/Red1 e/transfac/ (hamster), chick, 7.4/bin/get splice NFI-B1, Gallus vertebrate TFProf.cgi variant: T00551 NF-1B1 RPF-B. gallus s ?T00551 NF-1B2 NULL http://local host/cgi- bin/biobas e/transfac/ chick, 7.4/bin/get splice NF-1B2, Gallus vertebrate TFProf.cgi variant: T00552 NF-1B2 NFI-B2. gallus s ?T00552 NF-1B1 NULL 3-4 splice variants encoded by the NF- 1C gene: NF- 1C1/CTF- 1, NF- http://local 1C2/CTF- host/cgi- 2, NF- bin/biobas 1C4 and CTF-2 e/transfac/ (from (human), chick, 7.4/bin/get human NF-1C2, Gallus vertebrate TFProf.cgi sources) T00554 NF-1C2 NFI-C2. gallus s ?T00554 CTF-3 [1] NULL http://local host/cgi- bin/biobas e/transfac/ 7.4/bin/get NF-1/X, vertebrate TFProf.cgi T00610 NF-1X NFI-X. hamster s ?T00610 CD, activator NULL NMR, [13] [8] fluorescen may ce: DNA- cooperate binding with SRF domain is or MCM1 an on some independe promoters ntly [13] [8] folded ternary domain of complex alpha- formation helices with SRE and beta- and SRF sheet is elements, independe the 3 nt of conserved orientation Trp and being part distance of a to the hydrophob SRF site ic core [2] growth lung, high DNA- factor- testis; binding dependent HeLa, affinity BL2, http://local (Kd = 85 phosphory Ramos, host/cgi- pM) and lation in K562, bin/biobas specificity vivo at Jurkat, e/transfac/ [2] no MAP E418, Elk-1, human, 7.4/bin/get significant kinase in Saos, p62TCF, Homo vertebrate TFProf.cgi bending vitro sites IARC- T00250 Elk-1 TCF-A. sapiens s ?T00250 induced enhances EW17 [1] IAD domain, conserved within IRF http://local family, is host/cgi- responsibl bin/biobas e for e/transfac/ protein- interferon human, 7.4/bin/get protein regulatory Homo vertebrate TFProf.cgi interaction T04674 IRF-7A factor 7. sapiens s ?T04674 s [2] NULL transcripti onal repressor, acting N- through terminal ISREs 115 AA thus have 45% being an identity IRF-1 with IRF- antagonist 1, 47% [3] also identity inhibiting with IRF- binding of 2 [5] no ISGF3 to similarity ISREs [2] with IRFs mRNA for the C- induced terminal by IFN- 309 AA gamma, direct not by interaction IFN- ICSBP, with alpha/beta IFN either [5] consensu http://local IRF-1 or transcripti s host/cgi- IRF-2 on is sequence bin/biobas enhances activated binding e/transfac/ DNA- through a protein, mouse, 7.4/bin/get binding STAT-like IRF-8, Mus vertebrate TFProf.cgi capability element spleen, T00402 ICSBP IRF8. musculus s ?T00402 [2] [4] thymus [5] IFN consensu 13d: s widesprea sequence d; 18d: binding highest protein, level in ICSBP, spleen, ICSbp1, moderate Interferon in gut. Consensu induced lung, mid- s http://local by and Sequence host/cgi- recombina hindbrain, binding bin/biobas nt ChIFN low in protein, e/transfac/ type I and lens, icsbp1, chick, 7.4/bin/get ChIFN- heart, IRF8, IRF- Gallus vertebrate TFProf.cgi gamma forebrain T02037 ICSBP 8. gallus s ?T02037 within IRF [1] [2] family, demonstr ates the highest homology to IRF-4 binds to DNA in a complex with IRF- 1 or IRF- 2, or cooperativ ely with PU.1 or E47 IAD of ICSBP is responsibl e for the interaction alone, s with IRF cannot family activate members, transcripti IFN IRF- on [1] consensu http://local 1and IRF- activator s host/cgi- 2 [2] IAD in sequence bin/biobas is cooperatio binding e/transfac/ responsibl n with lymphoid protein, human, 7.4/bin/get e for the PU.1 or and IRF-8, Homo vertebrate TFProf.cgi interaction E47 [2] myeloid T02038 ICSBP IRF8. sapiens s ?T02038 s with Ets [1]. cells positive regulator of interferon- beta expressio n binds with the N- terminal part to interferon- and to virus- IAD2 inducible domain is enhancer conserved elements between [14] same IRF-1 DNA and IRF- binding 2, but is specificity different as IRF-2 in other the C- family terminal members part [1] IAD2 comprises http://local is a trans- IRF-1, host/cgi- responsibl activating ISGF2, bin/biobas e for domain IRF1, e/transfac/ protein- [12] Interferon mouse, 7.4/bin/get protein inducible regulatory Mus vertebrate TFProf.cgi interaction by IL-6 [4] T00422 IRF-1 factor 1. musculus s ?T00422 s [1] immediate NULL positive regulator of interferon- beta and IFN- induced genes [11] M-form tumor appears suppresso as 56- r kDa antagonizi protein ng IRF-2 IAD2 transformi domain is ng conserved potential between [9] IRF-1 deleted in and IRF- some 2, but is leukemias different and in other myelodys family plasias members showing [2] IAD2 cytogeneti http://local is c IRF-1, host/cgi- responsibl abnormalit ISGF2, bin/biobas e for ies of IRF1, e/transfac/ protein- chromoso Interferon human, 7.4/bin/get protein me 5 [10] regulatory Homo vertebrate TFProf.cgi interaction M- and G- T00423 IRF-1 factor 1. sapiens s ?T00423 s [2] forms of NULL immediate M-form -early appears gene, as 56- induced kDa by protein prolactin IAD2 in domain is lymphoma conserved cells [6] between here, two IRF-1 induction and IRF- peaks 2, but is have different been in other found at family early G1 members and [1] IAD2 during http://local is G1/S host/cgi- responsibl transition bin/biobas e for [3] same rat, e/transfac/ protein- DNA Rattus 7.4/bin/get protein binding IRF-1, norvegicu vertebrate TFProf.cgi interaction specificity T00424 IRF-1 ISGF2. s s ?T00424 s [1] as IRF-2 NULL the N- terminal region contain a characteri stic tryptophan repeat homolog (five of tryptophan mammalia s spaced n IRF-1 in 10- 18 (based of amino an overall acid amino intervals), acid which is identity of present in 63 - 65% all and 89 - members 91% of the IRF identity family within the (17698) N- specificall terminal y binds to 115 the residues, upstream http://local as regulatory host/cgi- compared region of IRF-1, bin/biobas with type I IFN IRF1, e/transfac/ hIRF-1 and IFN Interferon chick, 7.4/bin/get and inducible Regulator Gallus vertebrate TFProf.cgi mIRF-1) MHC T05092 IRF-1 y Factor 1. gallus s ?T05092 [1] class I NULL expressio n inducible by interferon s (IFN1 and IFNgamm a: primary fibroblasts ) and concanav amino alin A acid (splenic identity to culture) mammalia and n and dependent avian on paralogs: protein about synthesis 43% to (blockable IRF-4 by <T01572> cyclohexi <T04929> mide) [1] , 36% to seems IRF-8 mainly http://local <T00402> located in host/cgi- <T02037> the bin/biobas <T02038> nucleus IRF10, e/transfac/ , less (when Interferon chick, 7.4/bin/get than 30% expressed regulatory Gallus vertebrate TFProf.cgi to other in T05154 IRF-10 factor 10. gallus s ?T05154 IRFs [1] chicken NULL highly constitutiv similar to e IRF-2 transcripti (62% onal identity repressor, within the thus N- negative terminal regulator part, 25% of between interferon- the C- beta terminal expressio sequence n same s), but DNA lacking binding the acidic specificity region of as IRF-1 IRF-1 transformi [10] IAD2 ng domain is potential, conserved antagonizi between ng IRF-1 IRF-1 [6] and IRF- required 2, but is for different normal http://local in other hematopoi host/cgi- family esis and bin/biobas members B IRF-2, e/transfac/ [1] IAD2 lymphopoi PRDI- mouse, 7.4/bin/get is eses [5] BFc, Mus vertebrate TFProf.cgi responsibl enhanced T00425 IRF-2 PRDI-BFi. musculus s ?T00425 e for levels NULL negative constitutiv e highly regulator similar to of IRF-2 C- interferon- terminally beta truncated expressio forms n same observed DNA after binding virus- specificity inducible as IRF-1 proteolysi truncated s [5] IAD2 forms are domain is less conserved efective between repressor IRF-1 s than full- and IRF- length 2, but is IRF-2 [5] different enhanced in other levels family after members interferon- [1] IAD2 induction http://local is through host/cgi- responsibl IRF-1 bin/biobas e for binding to e/transfac/ protein- a ISRE PRDI- human, 7.4/bin/get protein within the BFc, Homo vertebrate TFProf.cgi interaction IRF-2 T01491 IRF-2 PRDI-BFi. sapiens s ?T01491 s [1] promoter NULL http://local host/cgi- IRF-2, bin/biobas IRF2, e/transfac/ Interferon chick, 7.4/bin/get Regulator Gallus vertebrate TFProf.cgi T05091 IRF-2 y Factor 2. gallus s ?T05091 NULL there is a sharp peak in IRF-3 expressio adult: n2 high in weaks lung, after birth spleen, http://local mRNA intestine; host/cgi- can be low in IRF3, bin/biobas slightly hen liver, Interferon e/transfac/ induced kidney; Regulator chick, 7.4/bin/get in male embryo: y Factor Gallus vertebrate TFProf.cgi livers by very low T01571 IRF-3 3, IRF-3. gallus s ?T01571 estrogen in liver IAD domain, conserved within IRF http://local family, is host/cgi- responsibl Interferon bin/biobas e for Regulator e/transfac/ protein- y Factor human, 7.4/bin/get protein 3, IRF3, Homo vertebrate TFProf.cgi interaction T04673 IRF-3 IRF-3. sapiens s ?T04673 s [2] NULL INTERFE http://local RON host/cgi- REGULA bin/biobas Transcripti TORY e/transfac/ on factor FACTOR mouse, 7.4/bin/get transcripti 3, IRF-3, Mus vertebrate TFProf.cgi on T05128 IRF-3 irf3, IRF3. musculus s ?T05128 regulation NULL activator activator of cytokine gene IAD expressio domain, n in both conserved Th1 and within Th2 cells IRF [1] family, is cooperate responsibl s with NF- IRF4, e for the ATc upon lymphocyt interaction IL-4 gene e specific s and induction interferon synergy in Th2 [1] regulatory with Ets activate factor, http://local family transcripti LSIRF, host/cgi- member on NF-EM5, bin/biobas PU.1 and synergistic interferon e/transfac/ with ally with lymphocyt regulatory human, 7.4/bin/get bHLH PU.1 in es, factor 4, Homo vertebrate TFProf.cgi factor myeloid myeloid T04929 IRF-4 MUM1. sapiens s ?T04929 E47 [3] [2] cells [2] cells high amino acid identity (77% of <T05117> ) to Xenopus IRF-6 http://local <T05117> expressio host/cgi- which is n of a IRF-5, bin/biobas most mammalia IRF5, e/transfac/ probably n IRF-5 Interferon mouse, 7.4/bin/get the frog ortholog Regulator Mus vertebrate TFProf.cgi ortholog regulated T05103 IRF-5 y Factor 5. musculus s ?T05103 [2] by p53 [1] NULL nuclear translocati on phosphory obviously lation regulated: experimen infection tally with NDV proven (Newcastl which is e disease caused virus) but for not with example Sendai by virus infection leads to of the nuclear correspon translocati ding cells on (in with NDV 2fTGH (Newcastl cells) [1] e disease does not virus) [1] bind to or IAD stimulate domain, promoter (adult:) conserved of IRF-7 spleen, within gene lymph IRF <G002599 node, http://local family, is > [1] thymus, host/cgi- responsibl regulates peripheral IRF-5, bin/biobas e for different blood IRF5, e/transfac/ protein- subset of leukocytes Interferon human, 7.4/bin/get protein IFNA , bone Regulator Homo vertebrate TFProf.cgi interaction genes marrow T05104 IRF-5 y Factor 5. sapiens s ?T05104 s [3] compared [1] 77% amino acid (embryo:) identity to expressed mouse at stages IRF-6 6, 8, 10, <T05103> 12 (weak which is signals in most the probably presumpti the ve mammalia mesoder n ortholog m except [1] DNA- for the binding notochord domain ) 14, 16, shared 18 67% (somitic amino mesoder acid expressio m of the identity n pattern posterior with appeared segment), human to 20, 25 IRF-5 partially (somitic <T05104> overlap mesoder , 45% with that m as a http://local with of the pair of Interferon host/cgi- mouse myogenic small Regulator bin/biobas IRF-1 transcripti regions y Factor clawed e/transfac/ <T00422> on factor adjacent 6, IRF-6, frog, 7.4/bin/get and 42% XMyf5 to the IRF6, Xenopus vertebrate TFProf.cgi with <T00949> midline) T05117 IRF-6 xIRF-6. laevis s ?T05117 mouse [1] [1] direct submissio http://local n of RNA host/cgi- sequence Interferon bin/biobas to EMBL, Regulator e/transfac/ no y Factor human, 7.4/bin/get cloning 6, IRF-6, Homo vertebrate TFProf.cgi paper T05118 IRF-6 IRF6. sapiens s ?T05118 available NULL direct submissio http://local n of RNA host/cgi- sequence Interferon bin/biobas to EMBL, Regulator e/transfac/ no y Factor mouse, 7.4/bin/get cloning 6, IRF-6, Mus vertebrate TFProf.cgi paper T05119 IRF-6 IRF6. musculus s ?T05119 available NULL http://local host/cgi- IRF7, IRF- bin/biobas 7, e/transfac/ Interferon mouse, 7.4/bin/get regulatory Mus vertebrate TFProf.cgi T05144 IRF-7 factor 7. musculus s ?T05144 conflict in activation NULL protein of IFNA sequence promoter between in EMBL transient entry transfectio #AF07649 n assay 4 and which is SWISSPR stronger OT entry upon #Q92985: virus- pos. 1-20 induction (MALAPE in R instead uninfected of cells MPVPER overexpre PAAGPD ssed SPRPGT protein RR), pos. present 425 (R mainly instead of located in Q) differs the from cytoplasm (adult:) isoform , whereas spleen, IRF-7A viral lymph <T04674> infection node, http://local by 13 increases thymus, host/cgi- amino nuclear peripheral bin/biobas acids at translocati blood e/transfac/ the very on [2] leukocytes interferon human, 7.4/bin/get amino- IRF-3 , regulatory Homo vertebrate TFProf.cgi terminal interferes appendix T05106 IRF-7H factor 7. sapiens s ?T05106 region with its [2] activator essential for function of mature NF-EM5, B- and T- PU.1 lymphocyt interaction es [3] partner, transcripti Pip, onal lymphoid- synergy specific with Ets interferon family regulatory factor factor, PU.1 [4] LSIRF-2, binds to interferon clones ISREs regulatory have induced factor 4, been in IRF-4, obtained lymphocyt Lymphocy that code es by te for a antigen Specific variant mimetic Interferon with an stimuli, Regulator extra Gln- but not by B cells, y Factor, 164 IFN-beta bone lsirf, nf- http://local ternary treatment marrow, em5, host/cgi- complex binds to spleen, IRF4, bin/biobas PU.1/IRF- DNA only thymus, transcripti e/transfac/ 4/DNA when B-cell onal mouse, 7.4/bin/get has been recruited lines, T- activator Mus vertebrate TFProf.cgi crystallize by cell lines T01412 NF-EM5 pip. musculus s ?T01412 d [2] phosphory [4] alternative splicing leads to isoform MEF-2 [1] additional isoforms are RSRFC4 and transcripti RSRFC9 onal [1] aMEF- activator cardiac, http://local 2 exhibits [1] smooth, host/cgi- a higher induced skeletal bin/biobas DNA- by MyoD, muscle; e/transfac/ binding involved placenta, human, 7.4/bin/get affinity in brain, Homo vertebrate TFProf.cgi than MEF- myogenes lung, T01006 aMEF-2 aMEF2. sapiens s ?T01006 2 [1] is kidney http://local host/cgi- bin/biobas rat, e/transfac/ Rattus 7.4/bin/get norvegicu vertebrate TFProf.cgi (muscle T01004 MEF-2 MEF-2. s s ?T01004 cells) activator [8] alternativeinvolved splicing in leads to myogenes aMEF-2, is [8] [6] RSRFC4, cooperate RSRFC9 s with direct myogenic interactionbHLH with factors other through E- myogenic box for cardiac, factors gene smooth, (bHLH activationskeletal proteins in muscle, MyoD, skeletal less in myogenin, muscle placenta, MRF4), cells [7] brain, but not MADS lung, with E2 domain of kidney proteins MEF2A is [8]; P19 [7] G2E both cells mutant necessary differentiat exhibits and ed into MCM1- sufficientneurons http://local binding for or host/cgi- specificitybinding toendoderm bin/biobas [5] MyoD [7] al cells, e/transfac/ heterodim undifferen synergistic MEF-2, human, 7.4/bin/get erization tiated MEF-2A, Homo vertebrate TFProf.cgi with MEF- activation P19 cells T01005 MEF-2 MEF2. sapiens s ?T01005 2D [1] of [4] transcripti alternative onal splice activator variants [11] have an cooperate insertion s with of 48 AA MyoD after through residue direct 86 or a interaction deletion s and by of 32 AA binding to in the C- either terminal MEF-2 region sites or to very high [11] E-box levels in calculated elements skeletal [8] muscle, isoelectric myogenin- lower in point is E12 brain, pI = 8.65 heterodim spleen [11] binds ers [11]; to MEF-2 synergistic developin sites [11] ally g brain gene activate [9]; P19 expressio transcripti cells http://local n in on in differentiat host/cgi- developin collaborati ed into bin/biobas g brain on with neurons, e/transfac/ see for MEF-2C C2C12 mouse, 7.4/bin/get detailed [2] in myotubes Mus vertebrate TFProf.cgi informatio adult (protein T01769 MEF-2C musculus s ?T01769 n [9] mice and level) [7] total of six MEF- 2D splice variants are cooperate known s with depending MyoD in the through presence direct or interaction absence s and via of either binding to MEF2D, exon A, A either MEF-2D, (MEF- MEF-2- MEF2DAB 2DA_, - sites or to , MEF-2D 2DA _, or E-box isoform -2D0_) elements AB, MEF- and [1] 2D (514 http://local presence mediates AA form) host/cgi- or serum (mouse), bin/biobas absence induction MEF-2D e/transfac/ of exon B of the c- isoform human, 7.4/bin/get (MEF- jun MEF- 1a Homo vertebrate TFProf.cgi 2D_B or - promoter T01770 2DAB (mouse). sapiens s ?T01770 2D_0) [3] [2] NULL 75% identical to cdc5 of Sacharom yces pombe over 223 amino acids comprisin g the DNA undergoe binding s rapid and nuclear nuclear translocati localizatio on in n response domains to [1] N- stimulatio terminal n with DNA serum [1] binding transcripti domain onal related to regulator PCDC5R Myb of G2 P, Pombe family progressio Cdc5- http://local transcripti n and related host/cgi- on factors mitotic protein, bin/biobas [1] C- entry [3] cell e/transfac/ terminal transcripti division human, 7.4/bin/get transactiv onal control Homo vertebrate TFProf.cgi ation activator T04728 Cdc5 protein 5. sapiens s ?T04728 domain [3] [2] NULL pI = 8.67 mouse SF-1 and ELP transcripts arise belongs Ad4BP, from the to small NR5A1, same group of (Y1, steroidoge structural orphan adrenocor nic factor http://local gene by nuclear tical 1, STF-1, host/cgi- alternative receptors tumor; fushi bin/biobas promoter which MA-10, tarazu e/transfac/ usage bind to Leydig factor mouse, 7.4/bin/get and 3 - DNA as tumor, homolog Mus vertebrate TFProf.cgi splicing monomer alphaT3- T01147 SF-1 1. musculus s ?T01147 [3]. s [1] 1) pI = 7.49 seems to be an belongs essential to small transcripti group of onal orphan factor for nuclear steroidoge receptors nesis as which well as bind to for the DNA as developm monomer ent of the s and reproducti recognize ve axis s [4] SF-1 additional and the nucleotide Ad4BP, thereby s NR5A1, regulated upstream steroidoge http://local genes of the nic factor host/cgi- are hexameric 1, fushi bin/biobas necessary half-site tarazu e/transfac/ for male (most pituitary factor human, 7.4/bin/get sexual often gonadotro homolog Homo vertebrate TFProf.cgi differentiat AGGTCA pe cells T02769 SF-1 1. sapiens s ?T02769 ion [3] motif) [1] [5] regulates the genes essential for gonadal developm ent and sexual differentiat ion in addition Ftz-F1, to the Ad4BP, steroidoge NR5A1, http://local nic P-450 STF-1, host/cgi- genes [2] fushi bin/biobas sexually tarazu rat, e/transfac/ dimorphic factor Rattus 7.4/bin/get expressio homolog norvegicu vertebrate TFProf.cgi n pattern T04002 SF-1 1. s s ?T04002 pI = 7.48 [2] NULL Ad4BP, steroidoge nic factor http://local 1, STF-1, host/cgi- fushi bin/biobas tarazu e/transfac/ factor cattle, 7.4/bin/get homolog Bos vertebrate TFProf.cgi T04014 SF-1 1. taurus s ?T04014 pI = 7.82. NULL Ad4BP, steroidoge nic factor http://local 1, STF-1, host/cgi- fushi bin/biobas tarazu e/transfac/ factor domestic 7.4/bin/get homolog pig, Sus vertebrate TFProf.cgi T04015 SF-1 1. scrofa s ?T04015 pI = 7.51 NULL http://local probably host/cgi- expressed Ftz-F1, bin/biobas in Ad4BP, e/transfac/ adrenal steroidoge chick, 7.4/bin/get glands, nic factor Gallus vertebrate TFProf.cgi ovary, T04016 SF-1 1, STF-1. gallus s ?T04016 pI = 7.81 testis [1] http://local host/cgi- Ftz-F1, bin/biobas Ad4BP, e/transfac/ steroidoge medaka, 7.4/bin/get nic factor Oryzias vertebrate TFProf.cgi T04017 SF-1 1, STF-1. latipes s ?T04017 pI = 8.17 NULL http://local host/cgi- bin/biobas Ad4BP, e/transfac/ testis, steroidoge frog, 7.4/bin/get brain, nic factor Rana vertebrate TFProf.cgi kidney, T04018 SF-1 1, STF-1. rugosa s ?T04018 pI = 7.82 spleen [1] Ftz-F1, Ad4BP, steroidoge nic factor http://local 1, STF-1, host/cgi- fushi bin/biobas tarazu zebra e/transfac/ factor fish, 7.4/bin/get homolog Brachyda vertebrate TFProf.cgi T04065 SF-1 1, zFF1. nio rerio s ?T04065 pI = 8.94 NULL Ftz-F1, Ad4BP, http://local STF-1, host/cgi- fushi bin/biobas tarazu e/transfac/ factor turtle, 7.4/bin/get homolog Trachemy vertebrate TFProf.cgi T04069 SF-1 1. s scripta s ?T04069 pI = 8.37 NULL after day 10.5, di- and mesencep halon and intestinal epithelium during embryoge nesis [3]; embryo: gut epithelium , brain: thalamus and roof TCF-4 of TCF-4 seems to midbrain has have an [1]; adult: multiple important widesprea RNA function d splice in the expressio http://local variants developm n with host/cgi- with ent of the high bin/biobas diverse vertebrate levels in e/transfac/ sequence liver and mouse, 7.4/bin/get s 3´ to gastrointe gastrointe Mus vertebrate TFProf.cgi the HMG stinal stinal T02915 TCF-4 musculus s ?T02915 box [1] tract [1] tract [1] 2 splice TCF- variants 4/beta- TCF-4B Catenin- <T02917> complex and TCF- activates 4E transcripti <T02878> on of [9] TCF- target 4 is an genes [2] element [9] in the of the absence Wingless- of beta- Wnt Catenin signaling TCF acts cascade: as a the negative presence regulator of a Wnt- of signal transcripti inhibits on [3] cell the lines CD- activity of NCM425 glycogen and synthase CC07 kinase- express 3beta high level hTCF-4, http://local (GSK3bet of TCF-4, human host/cgi- a) which after beta- TCF-4, bin/biobas in turn catenin transcripti e/transfac/ does not transfectio on factor- human, 7.4/bin/get phosphory n the 7-like-2, Homo vertebrate TFProf.cgi late beta- expressio T02918 TCF-4 TCF7L2. sapiens s ?T02918 Catenin n of the NULL high homology to human and murine TCF-4, C- serves as terminus nuclear reveals transduce homology r of the to splice Wnt-/Wg variants signaling TCF-4B cascade, and TCF- upon wnt- 4E, RT- / wg PCR signaling analysis TCF-4 anterior showed interacts part of that with beta- the http://local expressio catenin midbrain host/cgi- n of TCF- and (shown Xenopus bin/biobas 4 starts regulates by whole- laevis T- clawed e/transfac/ from late expressio mount in cell factor frog, 7.4/bin/get neurula n of situ 4, T cell Xenopus vertebrate TFProf.cgi stages target hybridisati T03404 TCF-4 factor 4. laevis s ?T03404 onward [1] genes [1] on) [1] http://local host/cgi- bin/biobas EF-C, RF- rat, e/transfac/ X, Rattus 7.4/bin/get regulatory norvegicu vertebrate TFProf.cgi T00229 RFX1 factor X1. s s ?T00229 (liver) monomeri c DNA- binding, spanning about 20 nucleotide s of one face of the DNA double helix [5] [6] major groove may play contacts an within the important contact role in core mesoder region, mal cell minor developm groove ent for binding in organ the formation flanking and sequence tissue s [5] may modeling T-cells be part of [1] (predom.); http://local complex mitogenic lymphoid host/cgi- arrays of stimuli cells: bin/biobas factor cause Ca- thymocyte e/transfac/ binding dependent s, bursal mouse, 7.4/bin/get sites, e. lymphocyt c-Ets-1, Mus vertebrate TFProf.cgi g. along phosphory es (all cell T00111 c-Ets-1 Ets1, p54. musculus s ?T00111 with lation [9] lines) [1] activator functional cooperatio n with AP- 1 [8] [6] and Sp1 [2] in some cases, repression of AP-1 negative effects net have charge (- been 10) of the reported trans- as well T-cells http://local activation which (predom.); c-Ets-1, c- host/cgi- domain depends lymphoid Ets-1 54, bin/biobas [4] on the C- cells [10]: Ets1, e/transfac/ phosphory terminal thymocyte p54, chick, 7.4/bin/get lation (Ca- repressing s, bursal p54c-Ets- Gallus vertebrate TFProf.cgi dependent domain lymphocyt T00114 c-Ets-1 54 1. gallus s ?T00114 ) [9] [1] es [10] activator alternative [8] [4] [6] splice stronger variant: c- activator Ets-1 54, than p54 differing splice in the N- variant [4] termini in functional addition cooperatio to the n with AP- mid- 1 at some regional promoters represing [8] [4] domain, levels the C- decrease terminal after T part of cell the induction molecule associatio also n with inhibits MafB http://local DNA- <T01433> T-cells host/cgi- binding causes (predom.); bin/biobas [2] inhibition e/transfac/ phosphory of thymocyte c-Ets-1 chick, 7.4/bin/get lation (Ca- erythroid s, bursal 68, p68c- Gallus vertebrate TFProf.cgi dependent differentiat lymphocyt T00115 c-Ets-1 68 Ets-1. gallus s ?T00115 ) [9] ion [1] es [10] cooperativ e binding 1H NMR: to several 2 zinc widely ions spaced coordinate half-sites d by 4 [2] Cys cooperativ http://local within e effects host/cgi- each zinc with AP-1 bin/biobas finger 2 do not ER, e/transfac/ perpendic require estrogen chick, 7.4/bin/get ular alpha- DNA- receptor, Gallus vertebrate TFProf.cgi helices binding T00264 ER-alpha NR3A1. gallus s ?T00264 [5] [1] by ER [3] NULL 86% (E15.5:) amino skeletal acid muscle, identity to (adult:) human skeletal http://local FOXO4 muscle, host/cgi- <T03403> heart, bin/biobas , 96% brown e/transfac/ identity and white AFX, mouse, 7.4/bin/get within the adipose AFX-1, Mus vertebrate TFProf.cgi fork head tissues T04176 FOXO4 AFXH. musculus s ?T04176 domain [1] [2] [1] (cell lines:) ES cells, (embryo:) metaneph ros, glomeruli, liver, stomach, expressed submand. in many gland tissues acini, but not all spinal cell types ganglia, [1] very chondrocy early tes, lung erpressed and lens in 8-16 epithelium cell , embryos vibrissae and both follicles, layers of (adult:) blastocyst brain, s [1] heart, http://local expressio skel. FHX.L, host/cgi- n muscle, fork head bin/biobas activated ovary, homologo e/transfac/ during lung, us X, mouse, 7.4/bin/get spermato kidney, long Mus vertebrate TFProf.cgi genesis testes, T04170 FOXJ2 isoform. musculus s ?T04170 [1] uterus [1] http://local host/cgi- full length bin/biobas sequence e/transfac/ has not human, 7.4/bin/get been none FKHL11, Homo vertebrate TFProf.cgi identified detected T02475 FOXL1 FREAC7. sapiens s ?T02475 so far [2] so far [2] http://local host/cgi- bin/biobas e/transfac/ glial cells human, 7.4/bin/get missing Homo vertebrate TFProf.cgi T02306 GCMa factor a. sapiens s ?T02306 NULL http://local host/cgi- bin/biobas e/transfac/ glial cells mouse, 7.4/bin/get missing Mus vertebrate TFProf.cgi T02307 GCMa factor a. musculus s ?T02307 NULL http://local host/cgi- bin/biobas e/transfac/ glial cells mouse, 7.4/bin/get missing Mus vertebrate TFProf.cgi T02308 GCMb factor a. musculus s ?T02308 NULL activator, mediates Ras- or Raf- heart, http://local response kidney, host/cgi- through liver, Ras- bin/biobas Ras- lung, responsiv e/transfac/ responsiv pancreas, e element human, 7.4/bin/get e placenta, binding Homo vertebrate TFProf.cgi elements skeletal T01975 RREB-1 protein 1. sapiens s ?T01975 (RRE) [1] muscle [1] http://local host/cgi- bin/biobas rat, e/transfac/ Rattus 7.4/bin/get norvegicu vertebrate TFProf.cgi T03882 SMAD-4 s s ?T03882 NULL http://local host/cgi- bin/biobas zebra e/transfac/ fish, 7.4/bin/get Brachyda vertebrate TFProf.cgi T03884 SMAD-4 nio rerio s ?T03884 NULL http://local host/cgi- bin/biobas e/transfac/ domestic 7.4/bin/get pig, Sus vertebrate TFProf.cgi T04252 SMAD-4 scrofa s ?T04252 NULL structure nuclear of CTD translocati (C- on terminal depends domain on or MH2 receptor domain) activated consists SMADs, of a beta- like sandwich SMAD-1 with a or SMAD- three- 2 in helix response bundle on to BMP4 one end or TGF- and a beta [13] collection it is of three surmised large that loops and activated an alpha- SMADs helix on bind the other SMAD-4 [12] CTD in the contains cytoplasm a primary and carry http://local homo- it into the host/cgi- oligomeriz nucleus DPC4 bin/biobas ation [13] (Deleted e/transfac/ activity forms a in human, 7.4/bin/get [12] a ternary pancreatic Homo vertebrate TFProf.cgi model of complex T04292 SMAD-4 cancer). sapiens s ?T04292 hetero- with NULL http://local host/cgi- bin/biobas e/transfac/ mouse, 7.4/bin/get Mus vertebrate TFProf.cgi T05067 SMAD-4 musculus s ?T05067 NULL homeo required domain is for most thyroid- closely specific related to gene that of expressio NK-2 n [12] (82% DNA- identity) binding [12] DNA- capability binding may be specificity regulated is through determine oxidation d by the of Cys-87 recognitio and Cys- n helix 363 [1] plus expressed additional at the parts of earliest the HD stages of [10] differentiat essential ion of for TTF-1 thyroid T/EBP, binding to and lung TTF-1, CAAG tissue thyroid http://local instead of [11] in the transcripti host/cgi- TAAT as lung, it is on factor bin/biobas most confined 1, thyroid rat, e/transfac/ other HD to nuclear Rattus 7.4/bin/get factors is bronchial factor 1, norvegicu vertebrate TFProf.cgi Gln-210 epithelium thyroid, T00856 TTF-1 Titf1. s s ?T00856 [3] three- at later lung [12] T/EBP, strong TTF-1, homology thyroid ( 98%) to thyroid transcripti the plays an gland on factor mouse important epithelium 1, thyroid TTF-1 role in the ; lung nuclear http://local with regulation (alveolar factor 1, host/cgi- absolute of lung type II thyroid- bin/biobas conservati developm cells and specific e/transfac/ on of the ent and bronchiola enhancer- human, 7.4/bin/get 60 AA surfactant r binding Homo vertebrate TFProf.cgi homeodo homeosta epithelial T00857 TTF-1 protein. sapiens s ?T00857 main [1] sis [4] cells) [4] expressio n in the neural http://local plate host/cgi- (embryon bin/biobas al) is e/transfac/ induced chick, 7.4/bin/get by sonic Gallus vertebrate TFProf.cgi hedgehog thyroid T00858 TTF-1 TTF-1. gallus s ?T00858 (Shh) [1]. cells, lung expressio n in the neural http://local plate host/cgi- (embryon bin/biobas al) is (embryoni T/EBP, e/transfac/ induced c) neural TTF-1, mouse, 7.4/bin/get by sonic plate [3]; Nkx2.1, Mus vertebrate TFProf.cgi hedgehog thyroid T00859 TTF-1 Nkx-2.1. musculus s ?T00859 (Shh) [2] cells, lung http://local host/cgi- bin/biobas e/transfac/ cattle, 7.4/bin/get Bos vertebrate TFProf.cgi (thyroid T01518 TTF-1 taurus s ?T01518 cells) TTF-1, http://local thyroid host/cgi- transcripti bin/biobas on factor e/transfac/ 1, thyroid dog, 7.4/bin/get nuclear Canis vertebrate TFProf.cgi T02098 TTF-1 factor 1. canis s ?T02098 NULL transcripti onal activator [13] [7] [12] [2] oncogene, transform s myeloid and (weakly) erythroid cells [11] difference s between the second DNA- binding the DNA- repeats binding of E26 domain and AMV resides in cause the N- different terminal phenotype http://local part [16] s of host/cgi- and transform bin/biobas interacts ed cells AMV, e/transfac/ with the [11] lacks avian 7.4/bin/get DBD of the myeloblas vertebrate TFProf.cgi C/EBPbet regulatory T00895 v-Myb v-Myb. tosis virus s ?T00895 a [3] phosphory NULL embryonic anterior pituitary; adult hippocam pus, ventrome activator dial in the nucleus developin of g hypothala thyrotroph mus, [3] piriform expressio cotrex, n varies medial with nucleus circadian of the rhythm amygdala; exhibiting 3 week: maximum brain, levels in heart, the spleen; evening 21 week: http://local and lung, host/cgi- minimum kidney, TEF, bin/biobas levels in muscle, thyrotroph rat, e/transfac/ the liver, Rattus 7.4/bin/get morning heart, embryonic norvegicu vertebrate TFProf.cgi similarly spleen, T01072 TEF factor. s s ?T01072 to DBP [1] brain TEF bound preferenti ally to the consensu http://local s host/cgi- sequence bin/biobas GTTACG lung, Thyrotrop e/transfac/ TAAT(bin liver, h human, 7.4/bin/get ding site spleen, Embryonic Homo vertebrate TFProf.cgi selection and T04876 TEF Factor. sapiens s ?T04876 assay) [1] kidney [2] http://local IgNF-A, host/cgi- NF-A, NF- bin/biobas A1, NF- e/transfac/ A2, oct- human, 7.4/bin/get B1A, oct- Homo vertebrate TFProf.cgi T00545 NF-A B1B. sapiens s ?T00545 NULL http://local IgNF-A, host/cgi- NF-A, NF- bin/biobas A1, NF- monkey, e/transfac/ A2, oct- Cercopith 7.4/bin/get B1A, oct- ecus vertebrate TFProf.cgi T01191 NF-A B1B. aethiops s ?T01191 NULL http://local IgNF-A, host/cgi- NF-A, NF- bin/biobas A1, NF- e/transfac/ A2, oct- mouse, 7.4/bin/get B1A, oct- Mus vertebrate TFProf.cgi T01192 NF-A B1B. musculus s ?T01192 NULL http://local host/cgi- B2 bin/biobas octamer e/transfac/ binding human, 7.4/bin/get (B cells, factor, Homo vertebrate TFProf.cgi BJA-B, T00663 oct-B2 oct-B2. sapiens s ?T00663 MOLT-4) http://local host/cgi- bin/biobas e/transfac/ (HeLa,BJ human, 7.4/bin/get A- Homo vertebrate TFProf.cgi B,MOLT- T00664 oct-B3 oct-B3. sapiens s ?T00664 4) two Oct-2 activator sequence [38], s actively differring supporting in the 16 AA assembly stretch at of basal 168-183 transcripti may on represent complex splice [8] has to variants be [40] [41], present a third for many one is rounds of Oct-2B transcripti bipartite on [8] DNA- expressed binding in CD4+, domain but not in with CD8+ T POUs cells and enhanced POUh by domain ionomycin [36] [6] , IgNF-A, http://local three Oct- ionomycin NF-A, NF- host/cgi- 2A- + PMA, A2, NF- bin/biobas related or antigen III, Oct-2, e/transfac/ peptides [9] down- Oct-2A, human, 7.4/bin/get in B cells regulated OTF-2, Homo vertebrate TFProf.cgi [45] by IFN- lymphoid T00647 POU2F2 OTF-2A. sapiens s ?T00647 interacting alpha or cells at least six splice variants known: Oct-2.1, Oct-2/Oct- 2A/Oct- 2.2, Oct- 2.3, Oct- 2.4, Oct- 2B/Oct- 2.5, and Oct-2.6 [4] the glutamine- rich region acts as trans- activation domain through proximal octamer elements B cells, IgNF-A, exclusivel induced NF-A, NF- http://local y [1] the pre-B A2, NF- host/cgi- C- cells; III, Oct-2, bin/biobas terminal, brain, Oct-2A, e/transfac/ proline- kidney; OTF-2, mouse, 7.4/bin/get rich trans- sperm; OTF-2A, Mus vertebrate TFProf.cgi activation activator 12d T00648 POU2F2 Oct-2.2. musculus s ?T00648 domain [1] embryo http://local lymphoid host/cgi- cells, bin/biobas intestine, e/transfac/ testis, 7.4/bin/get kidney, cat, Felis vertebrate TFProf.cgi nervous T00649 POU2F2 Oct-2. catus s ?T00649 system lymphoid cells, intestine, testis, kidney, nervous system, here in suprachia smatic and medial the four mammillar known y nuclei splice of variants hypothala (Oct-2.1, mus, Oct- granule 2/Oct2A/O and red ct-2.2, nucleus Oct-2.7, (adults), http://local and Oct- widesprea host/cgi- 2.8) differ up- d bin/biobas in their regulated expressio e/transfac/ DNA- by nerve n in Oct-2, rat, 7.4/bin/get binding growth emrbyonal Oct-2A, Rattus vertebrate TFProf.cgi specificity factor nervous T00650 POU2F2 Oct-2.2. rattus s ?T00650 [2] (NGF) [1] system [3] IgNF-A, http://local NF-A, NF- host/cgi- A2, NF- bin/biobas III, Oct-2, e/transfac/ Oct-2A, chick, 7.4/bin/get OTF-2, Gallus vertebrate TFProf.cgi T01032 POU2F2 OTF-2A. gallus s ?T01032 NULL http://local host/cgi- bin/biobas e/transfac/ human, 7.4/bin/get POU2F2 Homo vertebrate TFProf.cgi T00646 (Oct-2.1) sapiens s ?T00646 NULL http://local host/cgi- bin/biobas e/transfac/ Oct-2B, human, 7.4/bin/get OTF-2B, Homo vertebrate TFProf.cgi lymphoid T00662 POU2F2B Oct-2.5. sapiens s ?T00662 at least cells six splice variants known: Oct-2.1, Oct-2/Oct- 2A/Oct- 2.2, Oct- 2.3, Oct- 2.4, Oct- 2B/Oct- 2.5, and higher Oct-2.6 levels of [4] the Oct-2B glutamine- than of rich trans- Oct-2 in activation brain, domain testis, which and 12d acts embryo, through equal proximal concentrat octamer ions of B cells, elements both induced exclusivel isoforms pre-B y is N- in kidney, cells, http://local terminally less Oct- lower host/cgi- truncated 2B than levels in bin/biobas [1] the C- Oct-2 in brain, e/transfac/ terminal, B cells kidney, Oct-2B, mouse, 7.4/bin/get proline- and sperm; OTF-2B, Mus vertebrate TFProf.cgi rich trans- intestine 12d T00964 POU2F2B Oct-2.5. musculus s ?T00964 activation [5] embryos http://local host/cgi- bin/biobas e/transfac/ human, 7.4/bin/get Homo vertebrate TFProf.cgi T00665 POU2F2C Oct-2C. sapiens s ?T00665 B-cells involved in liver- specific gene expressio n inhibits HNF-1 action on aldolaseB promotor [3] RA induces transcripti on [4] http://local probably host/cgi- involved HNF3, bin/biobas in some HNF-3A, rat, e/transfac/ steroid HNF- Rattus 7.4/bin/get hormone liver HNF- 3alpha, norvegicu vertebrate TFProf.cgi regulatory (intestine, T00371 3alpha HNF-5. s s ?T00371 circuits [2] lung) (adult) pullmonar y (NCI- H441, Ishikawa, A549), hepatic http://local (HepG2), host/cgi- and Hepatocyt bin/biobas breast e Nuclear e/transfac/ (MCF-7 Factor 3 human, 7.4/bin/get and HNF- alpha, Homo vertebrate TFProf.cgi MD468)ce T02512 3alpha HNF3A. sapiens s ?T02512 ll lines usage of downstrea m translation initiation codons http://local gives rise nervous host/cgi- to N-Oct- system bin/biobas 5a [1], small e/transfac/ <T00632> cell lung N-Oct-3, human, 7.4/bin/get and -b cancer Brn-2, Homo vertebrate TFProf.cgi <T00633> (SCLC) T00630 POU3F2 Brain-2. sapiens s ?T00630 [1] cells [2] transcripti brain, onal hypothala activator mus: N-Oct- dorsomedi 3/Brn-2 al expressio paracellul n within ar region the of the hypothala paraventri mus cular colocalize nucleus, binding to s with medial http://local CAT and expressio and host/cgi- TAAT n of CRH lateral bin/biobas half-sites (corticotro posterior rat, e/transfac/ with 0, 2, pin- magnocell N-Oct-3, Rattus 7.4/bin/get or 3 nt releasing ular Brn2, Brn- norvegicu vertebrate TFProf.cgi spacing hormone) neurons T01524 POU3F2 2, Brain-2. s s ?T01524 [1] [1] [1] mediates response to several cytokines and MGF, hormones signal , in transduce particular r and to activator prolactin of http://local [3] [1] [2] transcripti host/cgi- phosphory on 5 A, bin/biobas lation of high in mammary e/transfac/ Tyr-694 lactating gland 7.4/bin/get most mammary factor, sheep, vertebrate TFProf.cgi likely by gland [3] T01578 STAT5A STF-IL-3. Ovis aries s ?T01578 Jak2 [2] [1] [2] mediates response to several cytokines and hormones MGF, , in high in signal particular lactating transduce to IL-2 mammary r and [2], IL-5 gland, activator highly [4], GM- thymus of http://local related to CSF [4], spleen; transcripti host/cgi- STAT5B, erythropoi moderate on 5 A, bin/biobas but etin [2] is in bone mammary e/transfac/ encoded activated marrow, gland mouse, 7.4/bin/get by a by IL-10 heart, factor, Mus vertebrate TFProf.cgi different and IL-3 kidney, T01579 STAT5A STF-IL-3. musculus s ?T01579 gene [4] [1] binds as lung [3] [4] homodime r and homotetra mer to consensu s GAS (interferon gamma- activated sequence s) motifs TTC(T/C) N(G/A)GA A [1] STAT5A tetramers bind to two tandem repeated GAS sites with an optimal spacing signal http://local of 6 bp transduce host/cgi- [1] r and bin/biobas STAT5A activator e/transfac/ binds to of human, 7.4/bin/get the beta- transcripti Homo vertebrate TFProf.cgi casein T04683 STAT5A on 5a. sapiens s ?T04683 promoter NULL modest activator [7] probably important for myocard developm ent [1] expressio n first detected in myocardio at least genic two progenitor different cells consensu during s binding early (cell sequence headfold lines). s [7] the stages, Fibroblast: potent then NIH3T3; trans- maintaine Bone activation d in marrow domain is cardiomyo stroma: maked by cytes of BAd; http://local the embryonic Thymic Csx, Nkx- host/cgi- alanine- , fetal and stroma: 2.5, bin/biobas and adult SCL-19; cardiac- e/transfac/ proline- heart [1] Lymph specific mouse, 7.4/bin/get rich C- also node homeobox Mus vertebrate TFProf.cgi terminus expressed stroma: T01675 Nkx2-5 protein. musculus s ?T01675 [7] in TSL-1 [1] in colestipol- treated hamster livers, the amount of membran e-bound precursor form is unchange d after treatment with increasing amounts of mevinolin (7d) whereas the mature form in http://local the host/cgi- nucleus bin/biobas decreases e/transfac/ (contrast hamster, 7.4/bin/get to SREBP- Cricetulus vertebrate TFProf.cgi SREBP- T01559 SREBP-1 1a. griseus s ?T01559 2) [1] NULL transcripti onal activator, acting through some E- box elements (carbohyd rate response element) [2] [1], but also through highest sterol- expressio regulatory n in element- brown 1 (SRE- adipose 1) [1] may tissue, play an low levels important in role in intestine, controlling spleen, skeletal determina muscle, http://local the dual tion- and thymus; host/cgi- DNA- differentiat nearly bin/biobas binding ion-linked undetecta rat, e/transfac/ specificity gene ble in Rattus 7.4/bin/get is due to expressio brain, norvegicu vertebrate TFProf.cgi Tyr-305 n in heart, T01562 SREBP-1 ADD1. s s ?T01562 [1] adipocyte testis [2] only zinc suppresse finger 2 s plus an myelomon adjacent ocytic basic differentiat region is ion [2] required high for DNA- levels of binding GATA-1 [10] [7] [5] in [3] DNA myeloblas binding ts requires correlate zinc (or with other reprogram heavy ming to metal thrombobl ions) [7] ast zinc phenotype finger 1 , contribute intermedia s strongly te levels to the with stability of eosinophil DNA binding at phenotype EF1, http://local some [2] at EFgamma host/cgi- particular least in erythroid a, Eryf-1, bin/biobas sites certain cells, GF-1, NF- e/transfac/ <R03093> transform megacary E1, NF- chick, 7.4/bin/get , ed cells, it ocytes, E1a, Gallus vertebrate TFProf.cgi <R03213> can also eosinophil T00267 GATA-1 Eryf1. gallus s ?T00267 , induce s [15] [2] transcripti required on of for GATA-1 erythroid gene in differentiat testis and ion [24] erythroid GATA-1 cells negative initiates proerythro at blasts different undergo promoters developm [2] [17] C- ental terminal arrest but not N- and death terminal [18] zinc GATA-2 finger (mRNA) required level is for DNA elevated binding in GATA- [29] and 1 interaction negative with Sp1 proerythro <T00752> blasts but [11] N- does not terminal compensa http://local zinc te for EF1, host/cgi- finger is GATA-1 erythroid EFgamma bin/biobas largely deficiency and a, Eryf-1, e/transfac/ dispensab [18] megacary GATA-1, mouse, 7.4/bin/get le in GATA-1 ocytic GF-1, NF- Mus vertebrate TFProf.cgi nonhema gene cells, [3] T00305 GATA-1 E1 (1). musculus s ?T00305 poietic expressio [1] [17]. activator negative regulator of gamma- globin in adults down- regulated by TPA [28] up- chromoso regulated mal by position aclacinom at Xp21- ycin 11 [33] (ACM) zinc [14] acts finger 2 is on the able to PBGD bind DNA and on its gamma- own but globin zinc promoter finger 1 in contribute associatio EF1 s strongly n with (chick), http://local to the Sp1 or EFgamma host/cgi- stability of CCACC a, Eryf1 bin/biobas DNA binding (chick), e/transfac/ binding at proteins GATA-1, human, 7.4/bin/get some [10] [13] GF-1, NF- Homo vertebrate TFProf.cgi particular [17] eosinophil T00306 GATA-1 E1. sapiens s ?T00306 sites [6] significantl s [3] during embryonal developm ent first the level erythroid of GATA- cells 1A (mainly mRNA embryonal predomin , prior to ates but terminal in later differentiat http://local stages ion) [1]; in host/cgi- and in the bin/biobas adult ventral clawed e/transfac/ erythroid region of frog, 7.4/bin/get cells the Xenopus vertebrate TFProf.cgi GATA-1B embryo T00304 GATA-1A GATA-1. laevis s ?T00304 mRNA [1]. [1]. class A activator specific [8] poorly domain DNA- [15] binding putative as leucine homodime zipper r due to motif an (L2TL2) inhibitory may be N- N- terminally terminal extended domain, due to the but avid lack of DNA- Q390 in binding in [28] any which heterodim brings an eric additional complex L in [27] [15] phase the spontaneo inhibitory us region homodime also rization in defines E12, B cells, different E2A.E12, http://local stabilized DNA- E2A-E12, host/cgi- by binding Pan-2 bin/biobas disulfide specificitie (rat), E2- e/transfac/ links [5] s alpha, human, 7.4/bin/get reducing between TCF3, Homo vertebrate TFProf.cgi activity in E12 and T00204 E12 E2A. sapiens s ?T00204 muscle E47 [15] ubiquitous http://local host/cgi- bin/biobas rat, e/transfac/ Rattus 7.4/bin/get E12, Pan- norvegicu vertebrate TFProf.cgi T00675 E12 2, E2A. s s ?T00675 NULL homodime rs and heterodim ers withfunctional MASH-2 redundan or ITF-2cy of E2A are and E2-2 gene inhibited from products DNA- [5], binding except by mature B cells interaction of the where bHLH E2A domain products with (E12/E47) calcium/care found almodulin complexeexclusivel s, y making whereas mature B E12/MyoDcell developm heterodim ent E2A- ers are dependent http://local resistant [2] host/cgi- [3] required bin/biobas flanking for Pax-5 e/transfac/ bases of <T01201> mouse, 7.4/bin/get the IgH E- Mus vertebrate TFProf.cgi box expressio T01786 E12 A7, E2A. musculus s ?T01786 specificall n [2] NULL http://local host/cgi- bin/biobas rat, e/transfac/ Rattus 7.4/bin/get E47, Pan- norvegicu vertebrate TFProf.cgi T00674 E47 1, E2A. s s ?T00674 NULL functional redundan http://local cy with host/cgi- other bin/biobas products a1, E47, e/transfac/ of the shPan1 mouse, 7.4/bin/get E2A and (hamster), Mus vertebrate TFProf.cgi E2-2 T01788 E47 E2A. musculus s ?T01788 genes [2] NULL myogenic factor, transcripti efficient onal DNA- activator binding [9] only after activates heterodim MyoD erization and with (e.g.) myogenin E12 [4] genes strong expressio cooperatio n n repressed between by MyoD N- and C- or terminal myogenin domains [9] it is for MRF4- transiently specific transcripti expressed onal after activation myogenin, [6] before phosphory MyoD, lation at and http://local several reappears host/cgi- Ser and during herculin bin/biobas Thr by late stage (mouse), rat, e/transfac/ PKA and of MRF4, Rattus 7.4/bin/get PKC in skeletal Myf-6 norvegicu vertebrate TFProf.cgi vitro and muscle myogenic T00512 MRF4 (human). s s ?T00512 in vivo developm cells http://local MyoD host/cgi- does not bin/biobas heterodim e/transfac/ erize with MEF1, human, 7.4/bin/get other myogenic Myf-3, Homo vertebrate TFProf.cgi myogenic transcripti myogenic T00525 MyoD MyoD. sapiens s ?T00525 factors [1] on factor cells at high muscle- concentrat specific ions: transcripti homodime on ric DNA- activator binding at may have low to concentrat cooperate ions, with myogenin other has to transcripti heterodim on factors erize for (NF-1, DNA- MEF-2, binding COMP1) [17] [8] may important have for specific muscle- function specific for trans- muscle activation formation and in some differentiat regions of ion: A86, the T87 [23] embryo, http://local N- and C- particularl host/cgi- terminal y in the bin/biobas regions latero- myogenic Myf-4 e/transfac/ have to ventral cells; (human), mouse, 7.4/bin/get cooperate body wall skeletal MyoG, Mus vertebrate TFProf.cgi for full disruption muscle T00528 myogenin myogenin. musculus s ?T00528 transcripti of its cells muscle- specific transcripti on activator induces myogenic differentiat ion [5] expressed after Myf- 5 and before MRF4 and MyoD, at low level in the skeletal muscle of adult rats [5] positively regulated by MyoD [6], by http://local IGF-I or host/cgi- preferenti other bin/biobas al signal myogenic rat, e/transfac/ heterodim pathways cells; Rattus 7.4/bin/get erization involving skeletal norvegicu vertebrate TFProf.cgi with E12 G muscle T01532 myogenin s s ?T01532 [3] [1] proteins cells [5] http://local host/cgi- bin/biobas clawed e/transfac/ E12, frog, 7.4/bin/get XE12, Xenopus vertebrate TFProf.cgi T01787 E12 E2A. laevis s ?T01787 NULL multiple activator splice mediates variants cAMP- [27] response leucine after zipper- phosphory independe lation at nt binding Ser-133 of the by PKA coactivato within the r CBP kinase- [16] the inducible Tax domain activator (KID) [32] of HTLV-I KID interacts cooperate with the s with Q2 basic domain in region [6] transcripti [7] onal decreasin stimulatio g the n Q2 spleen, dissociatio interacts heart, ATF-47, n with the thymus, CREB, constant TAF-110 lymphocyt CREB- for CREB componen es, gut, 341, http://local homodime t of TFIID brain, CREBalph host/cgi- rs (from 7 [10] kidney; a, CREB- bin/biobas nM to 0.1 dephosph very B, X2BP, e/transfac/ nM) and orylation weak X2-box human, 7.4/bin/get for may be expressio binding Homo vertebrate TFProf.cgi (CREB)2- by n in testis T00163 CREB protein. sapiens s ?T00163 DNA nuclear and liver multiple cAMP- splice dependent variants [22] [33] phosphory pI lation by (cal.)=5.7- PKA 6.0 [28] leads to leucine induction zipper- of trans- independe activation nt binding [45] [46] of [43] PKA coactivato regulatory r CBP subunit [13] RIalpha is interaction encoded with CBP by the is not tissue- inhibited specific by extinguish introducin er locus, ga Tse1, negative which charge in mediates spleen, position deactivati heart, ATF-47 142 on of thymus, (human), http://local (serine CREB gut, brain, CREB, host/cgi- phosphory [35] also kidney; CREB- bin/biobas lation or phosphory very 341, rat, e/transfac/ Asp- lation of weak CREBalph Rattus 7.4/bin/get substitutio Ser-133 expressio a, CREB- norvegicu vertebrate TFProf.cgi n) [4] the by CaM n in testis T00164 CREB B. s s ?T00164 Tax kinases I, and liver there are strong mutiple activator, splice mediating variants gene arising activation from the in CREB response gene [10] to cyclic CREBalph AMP a is the after largest phosphory and most lation abundant normal isoform function encoded is by exons required 2, 4, 5, 7- for long- 10a, 11 term [10] the memory coactivato [4] r CBP repression and the in negative undifferen regulator tiated CBP100 cells by interact CBP100 http://local with [8] loss of host/cgi- CREB CREB bin/biobas independe and ubiquitous e/transfac/ nly of the DeltaCRE , most CREB, mouse, 7.4/bin/get leucine B may be abundant CREBalph Mus vertebrate TFProf.cgi zipper [8] compensa in brain T00989 CREB a. musculus s ?T00989 [6] Q2 is ted by [14] becomes phosphory lated in hippocam pal neurons upon light exposure of the animals [2] in addition to enhanced activity by PKA- dependent phosphory lation, a calcium- dependent activation of calcineuri http://local n host/cgi- phosphata bin/biobas se is also e/transfac/ necessary 7.4/bin/get for full vertebrate TFProf.cgi trans- T01307 CREB CREB. hamster s ?T01307 activation NULL Phosphor ylation by a kinase different from PKA is induced by TGF- beta1, leading to http://local enhanced host/cgi- binding to bin/biobas a TRE e/transfac/ but does mink, 7.4/bin/get not alter Mustela vertebrate TFProf.cgi binding to (ML- T01380 CREB CREB. vison s ?T01380 pI 5.7-6.0 CRE CCl64) Bovine CREB is phosphory lated either by cAMP- dependent protein http://local kinase or host/cgi- by by bin/biobas Ca2+/cal e/transfac/ modulin- cattle, 7.4/bin/get dependent Bos vertebrate TFProf.cgi phosphory protein T01385 CREB CREB. taurus s ?T01385 lation kinase (brain) activator, activating capability comparabl e with CREB [1] ubiquitous ly expressed at very low levels, significantl y up- regulated in CREB/Del taCREB knock-out mice thus http://local compensa host/cgi- encoded ting the bin/biobas by creb loss of e/transfac/ gene major mouse, 7.4/bin/get exons 4, CREB Mus vertebrate TFProf.cgi 7-10a, 11 variants ubiquitous T02361 CREBbeta musculus s ?T02361 [1] [1] [1] encoded repressor, by crem CREB exons 1 antagonist (B), 3 (E), as 4 (F), 6 dominant (X), 7 (H), negative and the 5 regulator -half of [8] [4] exon 8 may (Ia) confer several cAMP/PK alternative A- splice dependent variants effects, mRNA: including even adult some stimulator brain: with an y ones, innerlayer alternative onto of DNA- other cerebral binding factors cortex, domain bound in anterior [8] very the thalamus, similar if vicinity of hippocam not CREMalp pus, identical ha [2] hypothala DNA- CREMalp mus [6], http://local binding ha is pituitary host/cgi- specificity upregulate gland; bin/biobas as CREB d in kidney, e/transfac/ [8] homo- CREB -/- heart; mouse, 7.4/bin/get and mice use very low CREMalp CREM- Mus vertebrate TFProf.cgi heterodim of an levels in T01314 ha alpha. musculus s ?T01314 eric DNA- alternative testis [7] http://local CREM, host/cgi- cAMP- bin/biobas responsiv e/transfac/ e element human, 7.4/bin/get CREMalp modulator Homo vertebrate TFProf.cgi T01803 ha alpha. sapiens s ?T01803 NULL repressor, CREB antagonist as dominant negative regulator [6] [3] CREMbet encoded a is by exons upregulate 1 (B), 3 d in (E), 4 (F), CREB -/- 6 (X), 7 mice (H), and repressor the 3 - function half of is exon 8 relieved (Ib) by several phosphory alternative lation of splice Ser-68, variants presumabl [6] binds y by PKA with [3] higher osmotic http://local affinity stimulatio host/cgi- than n of the mRNA: bin/biobas CREMalp supraoptic pituitary e/transfac/ ha to a nucleus, gland, mouse, 7.4/bin/get series of induction brain, CREMbet CREMbet Mus vertebrate TFProf.cgi different of kidney, T01315 a a. musculus s ?T01315 CREs [3] CREMbet heart [5] encoded by exons 1 (B), 3 (E), 4 (F), 7 (H), and the 3 -half of repressor, http://local exon 8 CREB host/cgi- (Ib) antagonist mRNA: bin/biobas several as pituitary e/transfac/ alternative dominant gland, mouse, 7.4/bin/get splice negative brain, CREMga CREMga Mus vertebrate TFProf.cgi variants regulator kidney, T01316 mma mma. musculus s ?T01316 [4] [4] [2] heart [3] encoded activator by crem [10] [9] exons 1 required (B), 2 (C), for 3 (E), 4 spermatid (F), 5 (G), differentiat 6 (X), 7 ion into (H), and sperms the 3 - [2] [1] half of abrupt exon 8 switch (Ib) from several repressing splice CREM variants isoforms [9] to compared CREMtau to alpha, during beta and spermato gamma genesis isoforms, [10] CREMtau alternative contains initiation two usage additional yields S- glutamine- CREM adult http://local rich CREMtau testis; host/cgi- regions is (much bin/biobas which upregulate weaker:) e/transfac/ exert an d in neuroend mouse, 7.4/bin/get activating CREB -/- ocrine Mus vertebrate TFProf.cgi effect, the mice tissues T01309 CREMtau CREMtau. musculus s ?T01309 second mediates [10] transcripti onal activator [2] involved in the cAMP dependent regulation http://local of host/cgi- catechola bin/biobas mine rat, e/transfac/ neurotran Rattus 7.4/bin/get smitter norvegicu vertebrate TFProf.cgi biosynthe T01919 CREMtau CREM-Ib. s s ?T01919 sis [1] NULL encoded by crem exons 1 (B), 2 (C), 3 (E), 4 (F), 6 (X),