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Movie Scene Quiz - Lite
By Pregniful Solutions LTD
Open iTunes to buy and download apps.
How well do you know movies? Can you even spell out titles correctly? Well - this fun yet simple game will test you, and we think that you will find the results surprising!
You see 'Movie Quiz?' is a simple yet super-addictive game that tests your ability to identify 400 different movie scenes by viewing a frame picture. This is a quiz game full of fun that consists of guessing the titles of selected movies such as horror, classic, drama, comedy, action and so on.
★★★★★Featured in iTunes in 375 places★★★★★
Most other quizzes include a hint or a field button to help you guess more easily. But we have made our quiz that bit more interesting; because you have to identify a movie exactly from accurately chosen movie scene then name it. This feature makes our quiz more addictive, as it requires the player to have considerable knowledge about movies, and does not solely rely on guesswork!
Will you be able to guess all the levels with 100% accuracy? To make it even more fun and interesting - you can test your friends and families knowledge of movies.
This amazingly fun game consists of:
- Four different levels (easy, normal, hard, and expert)
- Accurately reproduced movie scenes of famous movies
- 'Perfect Guess', alerts you when you have guessed correctly for the first time
- Game stats (score percentages for each level)
- Integrated Game Center
We are sure that you will love playing 'Movie Scene' and find it really enjoyable and challenging.
Here are a few tips if you are stuck and cannot guess the scene:
- Ask your friends or family if you don't know the answer!
- Search the internet (e.g. type name of famous person, where the person plays or music album),
- Ask on forums, Facebook or Twitter,
- Keep trying, maybe there is a typo error?
Are you ready to take the challenge and test your knowledge of famous movies?
Then play 'Movie Scene Quiz' and see how you score!
Have fun!
What's New in Version 1.3
-minor enhancements
-reduced app size
-minor bug fixes
iPhone Screenshot
Customer Reviews
I don't really like it
It would be more fun if I knew any of the movies I only got 2 of the easy ones!!!
- Free
- Category: Games
- Updated: Jan 04, 2013
- Version: 1.3
- Size: 31.3 MB
- Language: English
- Seller: Pregniful Solutions LTD
- © 25dev.net
Compatibility: Requires iOS 4.3 or later. Compatible with iPhone, iPad, and iPod touch.


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CHEmical Safety Assessment and Reporting tool
What is Chesar?
Chesar is an application developed by the European Chemicals Agency (ECHA) to help companies carry out their chemical safety assessments (CSAs) and prepare their chemical safety reports (CSRs) and exposure scenarios (ES) for communication in the supply chain.
Chesar enables registrants to carry out their safety assessments in a structured, harmonised and efficient way. This includes the importing of substance-related data directly from IUCLID, describing the uses of the substance, identifying risk management measures if needed, carrying out exposure estimates and demonstrating control of risks. Based on this, Chesar automatically generates the CSR and exposure scenarios for communication in an electronic exchange format and as a text document. It also facilitates the re-use (or update) of assessment elements generated in a single Chesar instance or imported from external sources.
- 19 February 2015 Shortcoming in Chesar 2.3 related to the use of ECETOC TRA workers when vapour pressure "changes" band between 25C and 40C Chesar 2.3 allows that an ES generated on the basis of an exposure estimation carried out with ECETOC TRA is valid for all temperatures up to 40C by default. This ensures that exposure scenarios sent to DUs cover the ambient temperature range in Europe. However, this may lead to an underestimation of exposure at temperatures between 25C and 40C. For those using Chesar 2.3 a work around is suggested.
- 09 December 2014 Changes in the user management of the Chesar website To improve user friendliness, ECHA will create a harmonised user management for ECHA's websites which require user identification. This will bring some changes in the user management of the Chesar website by Thursday, 11 December. When you log in to Chesar website for the first time after the changes are done, you will be asked for some additional information about your organisation.
- 04 June 2014 Chesar 2.3 supports SCED-based consumer assessment ECHA's Chemical Safety Assessment and Reporting tool (Chesar) has been updated to include consumer exposure estimations based on Specific Consumer Exposure Determinants (SCEDs). The new version 3.1 of the Targeted Risk Assessment (TRA) tool developed by the European Centre for the ecotoxicology and toxicology of chemicals (ECETOC) has been integrated in Chesar. When carrying out chemical safety assessments, exposure estimates for consumers can now be generated by using SCED data.

subset: commoncrawl


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Since this site has always been the hodgepodge that is things I do, it should come as no surprise that I change the rules of what goes here. As such Tabmail related stuff is on my new site: PopTopPaladin.com
Also because I'm incapable of doing things without reviewing them, I signed up for Pley which is basically Netflix (DVD) but for Lego sets, and have started my own little review site at TopBrick.net
Winter 2014-2015 Anime Season Reviews/First Impressions [Complete]
I have an excel spreadsheet that is an everyday reminder of why I am a failure of a human being. Anyway I have a section for the new season, and I have column called "Keeping" which even before the season starts, before I watch a single episode I often put a yes/no for things. There isn't a yes this season. Not even 1. Oh sure I still have some fall lefotvers, but as for something this season that I know I will want to watch – there's nothing on the plate.
Fall 2014 Anime Season Reviews/First Impressions [Complete]
Well fuck, here we go again. By which I mean I get more Mushishi to chill me out, and more Yowamushi to amp me up, and everything else can likely fuck off.
Apologies on the lack of updates in the game and tab space, but I've been busy. I'm currently finishing up the first version of the newly designed armor, and trying to get it done for AAC – hopefully I can make it, as I love AAC. I'll be there with the Nerdfit crew, and we'll also be heading to Alternicon in Boston sometime in November.
But minor stuff aside – HOLY CRAP Boston FIG. We had entered for their showcase a few months back after missing another contest, but not only did we advance but we got to go to the showcase, and if I have one complaint about that – it's that I was too busy to check out anything outside of our table (I the video game developer/major didn't even see a video game)
We had some great playtesting and feedback – and while I've done various playtesting amongst groups of people – it's a far different environment than a quiet sit-down, and if anything I prefer it. You really figure out what of your game you can say to draw them in more, and what parts you don't need to have because if it's too hard to explain when they can just as easily pick up and leave – you really get down into what you need to do for your game.
Another thing which my compatriot was beaming about was how much the art was complemented (we didn't get the Figgy award, but then we didn't have a sign up thing/code/any real sort of planning (we actually had to rush to get a tablecloth), but it was enough that both of us are excited to bring something next year which means good for me because I was afraid I wouldn't be able to steal Chris away from his animations to do my tabletop art.
There's some changes to the game that we'll be doing based on feedback, and some others things we wanted to add, but stay tuned. I also have an email list so feel free to email firstname.lastname@example.com to be added for when the game is released (although it'll be here too)
So next season looks okay? Nah that must be the dry spell that was this fucken season, because while I'm fine with my shounen's of Fairy Tail, Hunter, Pedal, and Baby Steps – anime as a whole has been shitty (and because of some peoples JRPG's) I've not even been able to watch Mushishi or Ping Pong as much.
Welcome!My name is John Andrews and this is my personal site where I sort of just place things. See the about page where you can find links to other stuff I do, or check out Games page for stuff here.
Game Pages


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Apple Help
It's free to register, to post a question or to start / join a discussion
Ipad to epson 435W printer
Likes # 0
Posted August 17, 2012 at 8:10PM
I recently purchased and Epson 435W printer. It prints perfectly off my computer but when I try to print from my Ipad(new version)I get the message "airprinter not found" Can anyone tell me where I am going wrong please?
Likes # 0
Posted August 17, 2012 at 8:25PM
Does your printer support Airprint - see here enter link description here
Likes # 0
Posted August 17, 2012 at 8:29PM
Further - you can download the Airprint App. for your iPad - see last paragraph in this LINK -
Likes # 0
Posted August 17, 2012 at 9:22PM
You will need Epson iPrint.
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Originally published on Wed March 26, 2014 2:58 pm
Nine days ago, the unbelievable became believable as an enthralled scientific community heard the announcement of an amazing experimental result: For the first time, astronomers detected signals from events dating back to the origin of the universe. Scientists heard the first echoes of creation.
A most recent episode of the long-running and vaunted TV program , "60-Minutes," entered the descriptive realm of 'Historic' in its highly documented interview with a respected physician-turned-research engineer, who shared the profound announcement that he and his colleagues have initiated the revolutionary and computerized era of 'Robotics.'
A nuclear physicist from UMass Amherst is among a select group of researchers that will be working on a experiment that hopes to find more about the way tiny subatomic particles behave in nature. WAMC's Lucas Willard spoke with David Kawall about the basics of the Muon g-2 experiment, which hopes to solve some of biggest mysteries in physics…
For more information please visit: http://www.umass.edu/researchnext/lords-muon-ring
Jesse Feiler is back in Studio A - this month's topic: the latest in government apps and information.


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Prices and availability are subject to change from the time and date that you print this page.
3/29/2015 10:40:45 PM. For Customer Service, please call 800.933.9904
$395.00 - $1,295.00
A chair designed for you and your little bundle of joy. Deep and comfy, it gently rocks back and forth on solid walnut legs. And, like all of our upholstered seating, its look will work in any room when baby makes the move to big kid bed. Round out the look of your Joya Rocking Chair with a coordinating Joya Ottoman.
Details, details
- A Monte ™ design
- Water repellent, stain resistant microfiber
- Oeko-Tex certified fabric
- High quality nylon webbing suspension provides lasting support
- All wood used is FSC certified
- Glue used in frame construction is water based and biodegradable
- Made in Canada
- More colors available
Show 'em what you're made of
- Chair has a hardwood and engineered plywood frame
- Microfiber with soy and plant-based foam
- Solid walnut wood base (rocker and ottoman)
- Click here to order Complimentary Swatches
Care instructions
- To prevent general soiling, frequent vacuuming or light brushing to remove dust, dirt or grime is suggested. Blot spills immediately with a white towel or sponge, or dab spills with a soft cloth. Spot clean, with a water-based solvent. Cleaning by a professional furniture cleaning service is recommended
The Land of Nod Guarantee
At The Land of Nod, nothing is more important to us than providing safe, high-quality products to you and your family. We believe that kids' products should be able to handle everything kids throw their way (literally and figuratively). That's why all of our products have an 18-year quality guarantee. And, hopefully, your kids will no longer be sleeping in bunk beds by then.
Knock, Knock.
Who's there?
Andy Green.
Andy Green, who?
Andy Green grass grows all around, all around.
Who's there?
Andy Green.
Andy Green, who?
Andy Green grass grows all around, all around.
Joya Rocking Chair & Ottoman
Our Designers Recommend
Customers Also Viewed
Joya Rocking Chairs & Ottoman (Heather Grey) is rated out of 5 by 25.
Rated 5 out of 5 by danihg from Love this item We really loved this chair! It took longer to receive than expected, but once we received it we were very happy with our purchase.
Date published: 2015-03-04
Rated 5 out of 5 by Cyndio from Sleek design will go beyond the baby years I am thrilled with this rocker. It's as comfortable as it is stylish. I love that this chair can go in any room and doesn't look like a traditional baby rocker. I can keep this as a reading chair in our master bedroom after the baby/nursing years. I couldn't be more thrilled with the quality, design, and practicality of this rocker
Date published: 2015-03-04
Rated 5 out of 5 by chrisc715 from Amazing rocker - comfortable AND looks great We purchased the Joya Rocker in heather grey for our nursery and absolutely love it. I wanted something that looks great+practical+comfortable. Not an easy combination since most comfy rockers can be pretty bulky. The Joya is stylish, has a small footprint, but is still very comfortable. The heather grey fabric is beautiful - much nicer than microfiber but just as easy to keep clean. I would also highly recommend getting the matching ottoman. Though the ottoman seems pricey, having the ability to kick your legs up or use it to rock is very worth it - plus it looks great together.
Date published: 2015-01-28
Rated 5 out of 5 by Fleurdelis from Beautiful and sturdy I bought this chair one year ago, and it is not only great looking, but also has been very helpful getting my little one off to sleep.
Date published: 2014-10-08
Rated 5 out of 5 by BabyShower from Great quality! Very good quality. Very comfortable and stylish.
Date published: 2014-10-07
Rated 5 out of 5 by Tashtash from Absolutely Perfect! We bought this rocking chair for our baby's nursery. It makes me just melt when I rock her in it! It is so comfortable and fits perfect with a nursing pillow on my lap. The leather is super easy to clean and always looks fresh. It was definitely the perfect modern rocker for our space1
Date published: 2014-08-19
Rated 5 out of 5 by BubbasMom from Sturdy and comfortable We've had this chair for almost two years now, and I still love it. It is simple, and clean, and sturdy. It doesn't overwhelm the room like so many of the big cushioned chairs. And it has been comfortable for me to rock a sick baby for hours at a time.
Date published: 2014-08-19
Rated 5 out of 5 by lisa45678 from Love this chair Hands down one of my favorite things in our mid century modern home. It is not only comfortable but well made. The pictures do not do the heather grey fabric justice--it's soft and durable. I'm so glad we went with this chair. Unlike a lot of modern furniture it is comfortable. Love, Love this!!
Date published: 2014-08-19
Rated 5 out of 5 by bethan143 from Great modern chair for nursery and beyond We bought this chair, white leather as shown, a couple of years ago when expecting our first baby. I used it in the nursery mostly for nursing and it was great for that (along with my nursing pillow), plus rocking of course. Now at 2 years old we still read in the chair every night for bed. We love the modern look, but just a heads up on the leather if you have cats.... unfortunately we did not think about our cats and their nails, so we have little holes all over ours. We should have seen that coming and chosen a different fabric.
Date published: 2014-08-06
Rated 5 out of 5 by Cyndio from Modern rocker will outlast your nursery days I bought this rocker for our master bedroom. It allows me to nurse and rock my baby to sleep. It's beautiful and very well made. What I love about it the most is that it's a chair we can keep long after our children are out of diapers.
Date published: 2014-08-05
Rated 5 out of 5 by Cabi from overall beautiful rocker I just got this rocker as a gift and is overall a great chair. The great thing about thisrocker is after the baby is older and I am not rocking him to sleep in the rocker in the baby's room, we can actually add this piece as a nice piece of furniture in our living area and not feel like it looks like a glider or a rocker we got just for the baby. Con is that the leather doesn't feel like the typical leather and kinda scared its gonna get dirty fast. We chose the leather because we thought it would be easier to clean, but now I feel like it won't clean as well as the typical leather, but still haven't tried it yet. But this rocker is slick and stylish and makes our room look modern. We also gotthe pouf from LON that makes a great foot rest. :)
Date published: 2014-03-31
Rated 5 out of 5 by ACelis from Perfection Like the last reviewer, I was hesitant to buy this rocker based on claims that it was too small. Oh, and the price tag was a bit hard for me to swallow, too. That said, I couldn't be happier that I bit the bullet and bought this for my first baby's room. It's comfortable, an ideal size (probably COULD seem small to a larger person; I'm 5'2), sturdy, and breathtakingly gorgeous. I'll have this thing forever, and it was worth every penny.
Date published: 2013-08-13
Rated 5 out of 5 by ACAB from gorgeous chair Just purchased this for our second baby's nursery. The price was a little daunting but it really a beautiful piece that I think will have a long life in our home, even after its nursery days are done. It has a small footprint, which we liked for our small nursery. It is quite comfortable, though haven't really put it to use since we are not due for another month. The fabric seems durable as well. Overall very pleased with this chair.
Date published: 2013-08-13
Rated 5 out of 5 by ReviewerDave from Multiple Uses! This rocker looks perfect in our nursery. It is very well made and is comfortable. It takes up a lot less space than several other rocking chairs and gliders. My wife and I bought this rocker with the purpose of using it in other rooms in the house once we change the nursery to a kids room. The look and feel of the chair will go well with the rest of our house and furniture. We haven't baby tested it yet (Nov), but our small dog loves it!
Date published: 2013-08-01
Rated 5 out of 5 by NodMom from So Comfortable I love the look of this rocker, but had hesitated buying at first because reviews on other websites said it was too small to be comfortable for nursing. I am glad we went ahead and purchased, because I couldn't disagree more. I am 5'6" and of average build. The rocker fits my baby and I perfectly. There is room to use a Boppy pillow. The arm rests are at the perfect height for support while nursing. I love that this does not look like your typical nursery rocker-glider. We actually have this chair in our living room and will be able to use it in any room of the house after baby grows. The heather grey microfiber is soft and feels great.
Date published: 2013-02-11


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This video is part of the following collections:
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text:
Are you Risa Takayanagi?Claim your profile
Publications (42)40.98 Total impact
Article: Evaluation of clinical bradycardiac effect and respiratory adverse effect of β-blocking agents in coronary computed tomography angiography based on theoretical analysis[Show abstract] [Hide abstract]
ABSTRACT: β-blocking agents are used for patients with tachycardia to improve the image quality of coronary computed tomography angiography (CCTA). In this study, we analyzed the clinical bradycardiac effects and the adverse respiratory effects of five β-blocking agents (landiolol, esmolol, propranolol, metoprolol and atenolol) used for CCTA. The changes of the occupancy binding to β1 or β2 receptor of these drugs were calculated based on the receptor occupancy theory. Thereafter, we predicted both the rate of heart rate decline ([Symbol: see text]HR) as a clinical effect and the rate of decrease in forced expiratory volume in 1 s ([Symbol: see text]FEV1) as an adverse effect, by using the ternary complex model. The results showed that the drugs with [Symbol: see text]HR greater than 10 %, necessary for CCTA, were as follows: landiolol at 13.5 %, propranolol at 11.0 %, and atenolol at 22.6 %. The [Symbol: see text]HR values at the end of CCTA for those three drugs were 0.3, 6.7, and 22.9 %, respectively. It is desirable for the bradycardiac effect to disappear at the end of CCTA. Therefore, landiolol is thought to be a preferable drug. On the other hand, [Symbol: see text]FEV1 at start and end of CCTA for those three drugs was 0.04-2.5, 34.9-40.3, and 6.0-6.1 %, respectively. Our results suggested that landiolol has the most appropriate effect and safety for patients with tachycardia who are undergoing a CCTA procedure.European Journal of Drug Metabolism and Pharmacokinetics 12/2014; DOI:10.1007/s13318-014-0244-3 · 1.31 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Triptans, serotonin 5-HT1B/1D receptor agonists, exert their action by targeting serotonin 5-HT1B/1D receptors, are used for treatment of migraine attack. Presently, 5 different triptans, namely sumatriptan, zolmitriptan, eletriptan, rizatriptan, and naratriptan, are marketed in Japan. In the present study, we retrospectively analyzed the relationships of clinical efficacy (headache relief) in Japanese and 5-HT1B/1D receptor occupancy (Phi1B and Phi1D). Receptor occupancies were calculated from both the pharmacokinetic and pharmacodynamic data of triptans. To evaluate the total amount of exposure to drug, we calculated the area under the plasma concentration-time curve (AUCcp) and the areas under the time curves for [cyrillic capital letter ef]1B and [cyrillic capital letter ef]1D (AUC[cyrillic capital letter ef]1B and AUC[cyrillic capital letter ef]1D). Moreover, parameters expressing drug transfer and binding rates (Acp, A[cyrillic capital letter ef]1B, A[cyrillic capital letter ef]1D) were calculated. Our calculations showed that [cyrillic capital letter ef]max1B and [cyrillic capital letter ef]max1D were relatively high at 32.0-89.4% and 68.4-96.2%, respectively, suggesting that it is likely that a high occupancy is necessary to attain the clinical effect. In addition, the relationships between therapeutic effect and AUCcp, AUCPhi1B, AUCPhi1D, and Acp[katakana middle dot]AUCcp differed with each drug and administered form, whereas a significant relationship was found between the therapeutic effect and APhi1B[katakana middle dot]AUCPhi1B or APhi1D[katakana middle dot]AUCPhi1D that was not affected by the drug and the form of administration. These results suggest that receptor occupancy can be used as a parameter for a common index to evaluate the therapeutic effect. We considered that the present findings provide useful information to support the proper use of triptans.The Journal of Headache and Pain 12/2014; 15(1):85. DOI:10.1186/1129-2377-15-85 · 3.28 Impact Factor
Article: Theoretical evaluation of antiemetic effects of 5-HT3 receptor antagonists for prevention of vomiting induced by cisplatin[Show abstract] [Hide abstract]
ABSTRACT: 5-HT3 receptor antagonists are widely used as antiemetic agents in clinical setting, of which palonosetron, with a long elimination half life (t 1/2), has recently become available. It is important to evaluate the concentration of serotonin when investigating the antiemetic effects of 5-HT3 receptor antagonists, as those effects are not based solely on the t 1/2 value. We theoretically evaluated the antiemetic effects of three 5-HT3 receptor antagonists (granisetron, azasetron, palonosetron) on cisplatin-induced nausea and vomiting by estimating the time course of the 5-HT3 receptor occupancy of serotonin. We estimated the 5-HT3 receptor occupancy of serotonin in the small intestine, based on the time course of plasma concentration of each 5-HT3 receptor antagonist and the time course of concentration of serotonin near the 5-HT3 receptor in the small intestine after administration of cisplatin. The antiemetic effect of each 5-HT3 receptor antagonist was evaluated based on the normal level of 5-HT3 receptor occupancy of serotonin. Our results suggest that an adequate antiemetic effect will be provided when a dose of 75 mg/m(2) of cisplatin is given to patients along with any single administration of granisetron, azasetron, or palonosetron at a usual dose. On the other hand, the 5-HT3 receptor occupancy of serotonin was found to be significantly lower than normal for several days after administration of palonosetron, as compared to granisetron and azasetron, indicating that constipation may be induced. Our results show that granisetron, azasetron, and palonosetron each have an adequate antiemetic effect after administration of 75 mg/m(2) of cisplatin.European Journal of Drug Metabolism and Pharmacokinetics 01/2014; 40(1). DOI:10.1007/s13318-014-0175-z · 1.31 Impact Factor
Article: Theory-based analysis of anti-inflammatory effect of TNF inhibitors on rheumatoid arthritis.[Show abstract] [Hide abstract]
ABSTRACT: TNF inhibitors are used as therapeutic agents for rheumatoid arthritis (RA). Each has a different dosage regimen and it is thought that the differences among them have implications on efficacy. However, those differences have not been analyzed in a theoretical manner. In the present study, we tried to explain theoretically the differences. We theoretically analyzed the anti-inflammatory effect of infliximab (IFX), etanercept (ETN), and adalimumab (ADA) for RA by using a pharmacokinetic and pharmacodynamic model. Then, we simulate values for sequential changes of tender joint count (TJC) after repeated administrations of TNF inhibitors by using the model. The sequential changes of TJC obtained with our model were in good agreement with observed TJC ratio data, which was considered to show the validity of our analytical method. The following results were obtained; the onset of clinical response was fastest with IFX, the fluctuation of IFX was greater than that of the others, the clinical response with ADA was as stable as that with ETN. The present model was useful to analyze theoretically the anti-rheumatic effect of TNF inhibitors. Our results showed that different dosage regimens have implications on the onset and fluctuation of clinical response.Drug Metabolism and Pharmacokinetics 01/2014; DOI:10.2133/dmpk.DMPK-13-RG-090 · 2.07 Impact Factor
Article: Investigation of the educational effectiveness of including small group discussion as part of a drug abuse prevention program for junior high school students.Yakugaku zasshi journal of the Pharmaceutical Society of Japan 01/2014; 134(12):1331-45. DOI:10.1248/yakushi.14-00004 · 0.31 Impact Factor
Article: Interactions between new quinolone antibacterials and diagnostic drug containing manganese.[Show abstract] [Hide abstract]
ABSTRACT: A diagnostic drug containing manganese chloride tetrahydrate as a major ingredient is available since 2006. It is used in magnetic resonance imaging as a negative contrast medium for magnetic resonance cholangiopancreatography of the gastrointestinal tract. However, there is no report regarding interaction between manganese and new quinolone antibacterials. We investigated the interactions between new quinolone antibacterials and a diagnostic drug containing manganese in vitro. We evaluated the rate of formation of chelate complex by reacting new quinolone antibacterials (levofloxacin, ofloxacin, ciprofloxacin) with a diagnostic drug containing manganese. The EC(50) values of the formation of chelate complex for levofloxacin, ofloxacin, and ciprofloxacin were 5.14 ± 0.14, 5.29 ± 0.14, and 0.96 ± 0.04 mM, respectively. The rates of formation of chelate complex by levofloxacin, ofloxacin, and ciprofloxacin in a reaction with the diagnostic drug were 17.0, 18.9, and 55.5 % in clinical condition, respectively. Our results suggest that a complex of each antibacterial and manganese was formed, with ciprofloxacin causing the strongest interaction. In addition, our findings indicate that the degree of interaction may be an important problem in clinical settings with concomitant administration of a new quinolone antibacterial and diagnostic drug containing manganese.European Journal of Drug Metabolism and Pharmacokinetics 02/2013; DOI:10.1007/s13318-013-0120-6 · 1.31 Impact Factor
Article: Theoretical analysis of efficacy of biological agent for rheumatoid arthritis based on target molecular binding occupancy.[Show abstract] [Hide abstract]
ABSTRACT: Recently, biological agents have been used for treatment of rheumatoid arthritis (RA), though the standard therapeutic doses vary among the agents utilized. To investigate the mechanisms related to those differences, we theoretically analyzed the target molecular binding occupancies of 4 biological agents: tocilizumab, infliximab, adalimumab, and etanercept. The average binding occupancy to the target molecule (Φ(ss)) was estimated to be 99.50 ± 0.44 % in a steady state after administration of the standard therapeutic dose of each agent. Furthermore, achieved American College of Rheumatology (ACR) 20, used as an index of clinical efficacy, increased in correlation with the value for Φ(ss). These results suggest that clinical effects are achieved with a high value of target molecular binding occupancy. Thus, we considered that all of the agents examined in this study are antagonists and elicit clinical efficacy by inhibiting the signaling of biologically active substances that are not necessary for life maintenance and are secreted or released specifically in pathological conditions. In addition, target molecular binding occupancy can be used as an appropriate index for evaluating the standard therapeutic dose of biological agent for RA.Rheumatology International 01/2013; DOI:10.1007/s00296-012-2650-7 · 1.63 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: ABSTRACT Oxycodone is an opioid widely prescribed to cancer patients for pain relief. However, the pharmacokinetics of oxycodone has not been sufficiently examined. Therefore the aim of this work was to study population pharmacokinetics of oxycodone in patients with cancer pain. The authors analyzed 108 serum oxycodone samples of 33 individuals with nonlinear mixed-effects model (NONMEM). Population pharmacokinetics was calculated using the one-compartment model of clearance, volume of distribution, bioavailability, absorption constant rate, and lag time. An exponential error model was used to determine interindividual variability and a relative error model was applied to assess residual variability. Population pharmacokinetics of oxycodone at the end point were as follows: CL(L/h) = 10.7 × [1 + (2 - Child-Pugh Classification)] (Class: A = 0, B = 1, C = 2); V(d) (L) = 193; k(a) (h(-1)) = 0.336; T(lag) (h) = 0.859; F (%) = 63.9. Interindividual variability was CL: 30.5%, V(d): 44.6%, and F: 37.0%, and residual variability was 16.2%. As the total clearance in patients with liver dysfunction (Child-Pugh class B) was reduced to 33.3%, serum concentration of oxycodone increased by 1.5. Therefore, it became clear that dose adjustments are essential when treating patients with liver dysfunction. These findings suggest that population parameters are useful for evaluating pharmacokinetics of oxycodone in patients with cancer pain.Journal of Pain & Palliative Care Pharmacotherapy 09/2012; 26(3):220-5. DOI:10.3109/15360288.2012.702200
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ABSTRACT: Determining the appropriate dose of transdermal fentanyl (TDF) for the alleviation of cancer pain requires determining the factors causing variations in serum fentanyl concentration after TDF treatment. The objective of this study was to identify these factors and incorporate them into a formula that can be used to predict serum fentanyl concentration after application of a TDF patch. Blood samples of cancer patients treated with a TDF patch for the alleviation of pain were collected at 24, 48, and 72 hours after application to evaluate population pharmacokinetics using the nonlinear mixed-effect model (NONMEM). Based upon this evaluation, Child-Pugh Score and use of a cytochrome P450 3A4 (CYP3A4) inducer were identified as the most significant factors in variations in serum fentanyl concentration and incorporated into the following Final Model formula: CL(fenta) (L/h) = 3.53 × (15 - Child-Pugh Score) × (1 + 1.38 × use or no use of CYP3A4 inducer). Bootstrap evaluation of the Final Model revealed a high convergence rate, suggesting that the model formula is a reliable and useful tool for determining TDF dose for the alleviation of cancer pain.Journal of Pain & Palliative Care Pharmacotherapy 06/2012; 26(2):98-104. DOI:10.3109/15360288.2012.679725
Article: [Survey on junior high school student's attitudes toward rational drug use and the educational effect by school pharmacists].[Show abstract] [Hide abstract]
ABSTRACT: The educational intervention could improve knowledge about rational drug use in the junior high school. Improving knowledge about rational drug use at an early age may be a good way to increase the population's awareness of health, medicines and self-medication. To educate the rational drug use, it is desirable that the school pharmacists participate in this educational program in the junior high school. So we conducted an educational lecture by school pharmacists to promote rational drug use and self-medication in junior high school students. The study compared participant responses before and after a lecture. After the first questionnaire, we lectured the mentioned above to them. Afterward, second questionnaire was conducted. In the second questionnaire, more than 95% of the students understood the contents of the lecture to some extent. After a lecture, students who answered that 'I don't have confidence that I can buy medicines rightly by myself' decreased from 42.7% to 11.7%. And students who answered that 'I don't have confidence that I can use medicines rightly by myself' decreased from 25.2% to 12.6%. It was possible to achieve a favorable modification of attitudes to rational use of medicines in junior high school students. Continuous interventions might allow better effects and could help to fill the gap in health education of the general population.YAKUGAKU ZASSHI 01/2012; 132(2):215-24. DOI:10.1248/yakushi.132.215 · 0.37 Impact Factor
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ABSTRACT: Kale (Brassica oleracea L. var acephala DC) is a leafy green vegetable belonging to the cabbage family (Brassicaceae) that contains a large amount of health-promoting phytochemicals. There are any reports about the effects of kale ingestion on the chemoprevention function and mechanism, but the interactions between kale and drugs have not been researched. We investigated the effects of kale intake on cytochrome P450 (CYP) metabolism by using cocktail probe drugs, including midazolam (for CYP3A4), caffeine (for CYP1A2), dextromethorphan (for CYP2D6), tolbutamide (for CYP2C9), omeprazole (for CYP2C19), and chlorzoxazone (for CYP2E1). Cocktail drugs were administered into rats treated with kale and cabbage (2000 mg/kg) for a week. The results showed that kale intake induced a significant increase in plasma levels and the AUC of midazolam, caffeine, and dextromethorphan. In addition, the plasma concentration and AUC of omeprazole tended to increase. Additionally, no almost differences in the mRNA expression levels of CYP enzymes in the liver were observed. In conclusion, kale ingestion was considered to have an inhibitory effect on the activities of CYP3A4, 1A2, 2D6, and 2C19 for a reason competitive inhibition than inhibitory changes in the mRNA expressions.Biomedical Research 01/2012; 33(4):235-42. DOI:10.2220/biomedres.33.235 · 1.15 Impact Factor
Article: Theory-based analysis of anti-inflammatory effect of infliximab on Crohn's disease and rheumatoid arthritis.[Show abstract] [Hide abstract]
ABSTRACT: In Japan, the recommended dosage regimens of infliximab (IFX) for treatment of rheumatoid arthritis (RA) and Crohn's disease (CD) are different. However, the differences have not been analyzed theoretically. In a previous study, we constructed a pharmacokinetic-pharmacodynamic model to investigate the effects of IFX for CD and found it useful to establish a rational dosage regimen of IFX for individual patients with CD. In the present study, we investigated whether the theory-based model could be used for cases of RA and also used it to evaluate the validity of the dosage regimen. The results obtained with our model were in good agreement with observed tender joint count (TJC) ratio data, which was considered to show the validity of our analysis. Thus, we concluded that the model could be used for patients with RA. Furthermore, a second administration of IFX given 2 weeks after the first infusion was important to achieve remission in the early stage of RA. We also compared the estimated pharmacodynamic parameters of RA with those of CD. The elimination rate constant of inflammation in RA was greater than that in CD, suggesting that the recovery from inflammation in RA is faster than that in CD, and indicating a reason for the difference in dosage between RA and CD. In conclusion, use of our model in light of the individual quantitative factor of tumor necrosis factor (TNF)-α allows establishment of IFX dosage regimens for individual patients.Rheumatology International 01/2012; 32(1):145-50. DOI:10.1007/s00296-010-1553-8 · 1.63 Impact Factor
Article: [Development and evaluation of effective learning system for patient interview training as a part of pre-education clinical pharmacy practice].[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to develop an effective learning system for patient interview training as a part of a pre-education clinical pharmacy. We devised a learning system for performing pharmaceutical care training and then investigated its usefulness. The learning content was a first interview with a simulated patient (SP). All students were divided into 8 groups of 5. Each student practiced interviewing an SP while 2 other students checked the performance of the interviewer, with roles rotated within each group. Additionally, the teachers also rotated among the groups to check the students. We evaluated the results contained in 55 check sheets used by teachers to evaluate the learning system, 223 check sheets used by students, and 110 check sheets used by the SPs. We found that there was a significantly greater number of students rated as unable to perform by the teachers as compared to those rated by the other students. In addition, the ratings for the items, "other symptom is confirmed" and "the severity and properties of the symptom are confirmed" were similar to the above result. Furthermore, there was a significantly greater number of students rated as unable to perform by the teachers as compared to those rated by the SPs in regard to the item "interviewed using open-ended questions." After the students had performed their first attempt at a first interview, 28.6% were rated as unable to perform by the teachers, which was significantly reduced to 15.8% after the fourth attempt and 10.4% after the fifth attempt. Our results indicate that students must practice the first interview at least 4 times before reaching a level of competency. In addition, our findings suggest that both teachers and SPs should undertake pre-education training in clinical pharmacy practice, as the evaluations were significantly different among the teachers, students, and SPs in the present study.Yakugaku zasshi journal of the Pharmaceutical Society of Japan 01/2011; 131(1):153-9. DOI:10.1248/yakushi.131.153 · 0.31 Impact Factor
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ABSTRACT: Kale is a cruciferous vegetable (Brassicaceae) that contains a large amount of health-promoting phytochemicals. The chronic ingestion of cabbage of the same family is known to accelerate conjugating acetaminophen (AA) and decrease the plasma AA level. Therefore, we examined to clarify the effects of kale on the pharmacokinetics of AA, its glucuronide (AA-G) and sulfate (AA-S). AA was orally administered to rats pre-treated with kale or cabbage (2000 mg/kg/day) for one week. Blood samples were collected from the jugular vein, and the concentrations of AA, AA-G and AA-S were determined. In results, kale ingestion induced an increase in the area under the concentration-time curve (AUC) and a decrease in the clearance of AA, whereas cabbage had almost no influence. In addition, there were significant differences in the AUC of AA-G between the control and kale groups. mRNA expression levels of UDP-glucuronosyltransferases, the enzymes involved in glucuronidation, in the kale group were significantly higher than those in the control group. In conclusion, kale ingestion increased the plasma concentrations of both AA and AA-G. The results suggest that kale ingestion accelerates the glucuronidation of AA, but an increase of plasma AA levels has a different cause than the cause of glucuronidation.Biomedical Research 01/2011; 32(6):357-62. DOI:10.2220/biomedres.32.357 · 1.15 Impact Factor
Article: Receptor occupancy theory-based analysis of interindividual differences in antiemetic effects of 5-HT3 receptor antagonists.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to estimate interindividual differences in the antiemetic effects of 5-HT(3) receptor antagonists by evaluating the influence of pharmacokinetics on 5-HT(3) receptor occupancies, based on receptor occupancy theory. We analyzed interindividual differences of 5-HT(3) receptor occupancies and antiemetic effects after the oral and/or intravenous administration of standard doses of the following 5-HT(3) receptor antagonists: azasetron, granisetron, indisetron, ondansetron, ramosetron, and tropisetron. The interindividual difference between maximum and minimum 5-HT(3) receptor occupancies after oral administration ranged from 0.6% to 64.0%, and that difference after intravenous administration ranged from 0.6% to 29.6%. Following oral administration, the interindividual difference between maximum and minimum complete vomiting inhibition rates ranged from 0.2% to 16.1%. After intravenous administration, that difference ranged from 0.8% to 52.5%. Interindividual differences in the clinical effects of 5-HT(3) receptor antagonists could be evaluated based on receptor occupancy theory, and the differences varied among drugs. Drug selection considering these individual variations might be useful for the patients who experienced vomiting associated with chemotherapy.International Journal of Clinical Oncology 12/2009; 14(6):518-24. DOI:10.1007/s10147-009-0912-5 · 2.17 Impact Factor
Article: Single nucleotide polymorphisms of 17beta-hydroxysteroid dehydrogenase type 7 gene: mechanism of estramustine-related adverse reactions?[Show abstract] [Hide abstract]
ABSTRACT: To investigate the influence of single nucleotide polymorphisms (SNP) on transcription of the 17beta-hydroxysteroid dehydrogenase (HSD17B7) gene. Luciferase reporter genes containing a 5'-flanking of the HSD17B7 gene, as well as the sequence around the SNP, were transfected into LNCaP and DU145 cells. Then, luciferase assays were carried out. The presence of the G allele resulted in an increase of transcriptional activity derived from the 5'-flanking region of the HSD17B7 gene by 270% and 370% in LNCaP and DU145 cells, respectively. Transcriptional activity of the HSD17B7 gene containing the G allele was higher than that of the C allele. The transcriptional activity of the HSD17B7 gene containing the G allele is higher than that of the C allele. This difference in HSD17B7 expression may regulate the risk of peripheral edema as an adverse reaction induced by estramustine phosphate sodium.International Journal of Urology 10/2009; 16(10):836-41. DOI:10.1111/j.1442-2042.2009.02374.x · 1.80 Impact Factor
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ABSTRACT: We established a network meeting system program and used it to review a prior pharmaceutical practice training session. Pharmacists at Tokai University Hachioji Hospital gave lectures about dispensing and other tasks performed by clinical pharmacists to third-year undergraduate students at Tokyo University of Pharmacy and Life Sciences. After the lectures, discussions were held using the network meeting system, after which a questionnaire was completed by the students. The questionnaire was answered by 530 students, of whom approximately 90% expressed interest in the program, 80% noted approval of the media used in the system, and 94% thought that the program was useful. Thus, we concluded that the students were motivated by the program to remember what they had learned in the lectures. We also found that the quality of data communication had an effect on the interests and motivation of the students. Based on their evaluation of the media, it was considered that improvements in communication regarding the system were necessary, though the evaluation of the utility of the program was not influenced by the quality of data communication. As a result, we concluded that our network meeting system program was useful to review prior learning of pharmaceutical practice.Yakugaku zasshi journal of the Pharmaceutical Society of Japan 01/2008; 127(12):2027-33. DOI:10.1248/yakushi.127.2027 · 0.31 Impact Factor
Article: Analysis of pharmacological effects of drugs used for treatment of urinary disturbance based on anticholinergic and smooth muscle-relaxing effects.[Show abstract] [Hide abstract]
ABSTRACT: Propiverine hydrochloride, oxybutynin hydrochloride and terodiline hydrochloride have both anticholinergic and antispasmodic effects, and are used for the management of urinary frequency and incontinence. The average standard therapeutic doses of these drugs differ greatly. We retrospectively analyzed their pharmacological effects with consideration given to muscarinic acetylcholine receptor binding affinities, anticholinergic activities, and inhibitory effects on KCl-induced contraction. Muscarinic acetylcholine receptor occupancies and the inhibitory ratios of the drugs for both acetylcholine-induced and KCl-induced contraction in a steady state after oral administration of standard doses were calculated based on pharmacokinetics and the receptor occupancy theory. The average muscarinic acetylcholine receptor occupancy and inhibitory ratio of acetylcholine-induced contraction were estimated to be 12.6+/-1.06% and 3.27+/-0.74%, respectively, with no significant differences found between the drugs for those parameters. A significant linear relationship was found between muscarinic acetylcholine receptor occupancy and the maximum ratio of increase in bladder urinary capacity. On the other hand, the inhibitory ratios of KCl-induced contraction varied from 0.01 to 0.48%. The present results suggest that muscarinic acetylcholine receptor occupancy is a principal determinant of the therapeutic effect of a drug used for treatment of urinary disturbance.Biological & Pharmaceutical Bulletin 08/2007; 30(7):1297-300. DOI:10.1248/bpb.30.1297 · 1.78 Impact Factor
Article: [Analysis of antiemetic effect of various dosage regimens of azasetron hydrochloride based on 5-HT3 receptor occupancy of serotonin].[Show abstract] [Hide abstract]
ABSTRACT: Antineoplastic drugs have been shown to exert direct effects on the gut and induce the release of serotonin from the enterochromaffin cells of small intestinal mucosa. It is thought that released serotonin stimulates vagal afferent fibers through 5-HT3 receptors located in the vagal afferent terminals in the gastrointestinal tract and initiates sensory signals to the area postrema and the emetic center, thereby initiating nausea and vomiting. A 5-HT3 antagonist competitively inhibits serotonin at its specific binding sites, 5-HT3 receptors, and thereby elicits an antiemetic effect. Therefore 5-HT3 receptor occupancy of serotonin may be an appropriate indicator of the antiemetic activity of 5-HT3 antagonists. We analyzed 5-HT3 receptor occupancy of serotonin by integrating pharmacokinetic and receptor-binding kinetic parameters based on the receptor occupancy theory to compare the strength of the antiemetic effects of three dosage regimens of azasetron hydrochloride. The inhibitory effects on the binding of serotonin to 5-HT3 receptor of regimen 2 (an intravenous bolus injection of 5 mg of azasetron hydrochloride before and 8 h after chemotherapy) and regimen 3 (an intravenous bolus injection of 2.5 mg followed by 7.5 mg continuous intravenous infusion for 24 h) were longer-lasting than those of regimen 1 (an intravenous bolus injection of 10 mg before the start of chemotherapy). Furthermore, a positive relationship was found between the time of inhibitory effects on the binding of serotonin to 5-HT3 receptor and antiemetic effects of azasetron hydrochloride. From these results, dosage regimens 2 and 3 were considered to be more effective in the long term than regimen 1 in prophylaxis of nausea and vomiting induced by cisplatin.Yakugaku zasshi journal of the Pharmaceutical Society of Japan 03/2007; 127(2):353-7. · 0.31 Impact Factor
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ABSTRACT: Tumor necrosis factor (TNF)-alpha, a primary mediator of inflammatory responses, is increased in patients with active Crohn's disease (CD) and considered to play an important role in the regulation of inflammation in CD. Infliximab (IFX) is a chimeric murine-human monoclonal IgG1 antibody that targets TNF-alpha and is used as a therapeutic agent for CD. Although that dosage regimen has been established through clinical trial experience, it has not been analyzed theoretically. We analyzed of sequential changes of the Crohn's disease activity index (CDAI) using a pharmacokinetic-pharmacodynamic model integrating the pharmacokinetics of IFX and turnover rate of TNF-alpha. The time course effects of IFX derived from the present model were matched to reported data regarding CDAI ratios, and we found that the clinical effect of IFX reached a maximum value 2 to 4 weeks after administration and was maintained for the next several weeks. Our results suggested that the standard dosage regimen of IFX is theoretically appropriate. Further, based on the results of various dosage regimens, a second administration of IFX 2 weeks after the first dose was shown to achieve remission in the early stage of active CD, when IFX was given as a repeated treatment.Drug Metabolism and Pharmacokinetics 03/2007; 22(1):20-5. DOI:10.2133/dmpk.22.20 · 2.86 Impact Factor
Top Journals
Tokyo University of Pharmacy and Life Science
Edo, Tōkyō, Japan
- • Department of Clinical Evaluation of Drug Efficacy
- • School of Pharmacy
The University of Tokyo
Edo, Tōkyō, Japan
- Department of Pharmacy


text:
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text:
Can Hiv Put A Hump On You Back
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
doubt abt hiv (CAN YOU GIVE YOURSELF HIV/AIDS, 2010) (PILLOW POUNDING, PILLOW HUMPING, 2010)dear dr i made a sex toy by making hole in pillow..and having sex really..when i think abt 2 masturbate.i m using this sex toy..some times my semen enters into the pillow..and i dont mind it..does this practise leads to hiv infection? i have...
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation...is not transmitted. It appears you have much to learn.Good luck.Dr. BobExperimenting with Masturbation (CAN YOU GIVE YOURSELF HIV/AIDS, 2009) (PILLOW POUNDING, PILLOW HUMPING, 2009) Nov 21, 2009Hello doc i find it uncomfortable to masturbate... Read more »
Experimenting with Masturbation (CAN YOU GIVE YOURSELF HIV/AIDS, 2009) (PILLOW POUNDING, PILLOW HUMPING, 2009)Hello doc i find it uncomfortable to masturbate with my hands so i use a pillow, but my question is... Read more »
HIV + "Buffalo Hump"Iam 68 and just had liposuction procedure done on my back and neck. What are the chances of the... Read more »
HIV/AIDS and Lipodystrophy Treatments Part I: Treatments for Fat Gain... Body shape changes Lipohypertrophy: Fat gain in the breasts, back of the neck (buffalo hump),visceral fat in the belly, or round lumps that appear under the skin(lipomas) Lipoatrophy: Loss of... Read more »
Lipodystrophy, Body Changes and HIV/AIDS... Face (sunken cheeks) Fat build up may happen in the: Stomach Breasts Back of the neck ("buffalo hump") Round lumps of fat may appear under the skin (lipomas) Some studies show that lipodystrophy affects men... Read more »
Over the Hump...people can't keep doing it over and over. Everybody needs to get involved." Now Lambert is working to bring better access to HIV/AIDS information and treatment to Aboriginal people living on reserves and in rural areas. He's also outspoken about... Read more »
HIV/AIDS and Lipodystrophy Treatments Part III: Treatments for Metabolic Changes... Body shape changes Lipohypertrophy: Fat gain in the breasts, back of the neck (buffalo hump),visceral fat in the belly, or round lumps that appear under the skin(lipomas) Lipoatrophy: Loss of... Read more »
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Buffalo Hump Just Starting
Posted by mike55, 6 Replies...successly treated with Trizivir for four years (since becoming HIV+). All was well until a few weeks ago I noticed the dreaded hump starting to appear behind my neck. I would like to hear experiences from anyone going through this type of... Read more »
Dry Humping that wasn't so dry...
Posted by Sharpie, 1 ReplyHi, The other day I was with a guy and he was grinding himself against my anus. He was leaking a lot of precum and he tried to insert himself (no condom) a few times. He never actually inserted himself but he was poking quite hard. Risk or no? ... Read more »
buffalo hump
Posted by Anonymous, 5 Replies...has anyone experienced a "buffalo hump"? my doctor says that not enough information is known about the cause or treatment of it. i have consulted with a plastic surgeon Read more »
Atripla and weight gain
Posted by mimilove, 2 Replies...same info keeps coming back that Atripla does not cause weight gain. Well, I feel this is false information because a lot of hivers claim the same condition of weight gain with Atripla....I have been diagnosed in 2007 and have been on Atripla... Read more »
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March 29, 2015
KABUL, Afghanistan (AP) -- An appeals court in Afghanistan has overturned a death sentence for a journalism student who was accused of blasphemy.
The student was charged for asking questions in class about women's rights under Islam.
But even though they overturned the death sentence, the judges still sentenced the man to 20 years in prison.
The case has come to symbolize the move in Afghanistan toward an ultraconservative view on religious and individual freedoms.
The student (Parwez Kambakhsh) told the AP as he left the courtroom that he doesn't "accept the court's decision," which he called "unfair."
The case can still be appealed to Afghanistan's highest court.
Besides the accusation that he disrupted class with his questions, prosecutors also said the man had illegally distributed an article he printed off the Internet that asked why Islam doesn't modernize to give women equal rights.
(Copyright 2008 by The Associated Press. All Rights Reserved.)
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text:
A Car Trip Alphabet
A car trip provides the opportunity to see or experience things for every letter of the alphabet, from "ambulance" to "zoom."
Publisher: New York : Clarion Books, c1994.
Characteristics: [30] p. :,col. ill. ;,18 x 23 cm.
Alternate Title: ABC drive!
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Free Hot Tub
MagnoliaMommyJuly 9, 2005
When we moved in (about 5 years ago) there was a hot tub left next to the shed. My genius plan was to dig a hole & drop it into the ground... make a koi pond. It has never happened. So, if anyone wants to come & get it... it's yours.
I live in South East Texas an hour Northwest of Houston.


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Kreenig Snarlsnout
This NPC can be found in Northern Barrens.
Quotes (1)
- Kreenig Snarlsnout yells: Come and face me! *snort* I can smell your troll stench from here.
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4410 North Sacramento Avenue
Albany Park, Chicago, 60625
Commute to Downtown Skokie
Most errands can be accomplished on foot.
Many nearby public transportation options.
Flat as a pancake, some bike lanes.
Score Details
4410 North Sacramento Avenue has a Walk Score of 87 out of 100. This location is Very Walkable so most errands can be accomplished on foot.
This location is in the Albany Park neighborhood in Chicago. Nearby parks include Horner Park, Buffalo Park and Ravenswood Park.
Nearby schools include North River Elementary School, Bateman Elementary School and Korean American Child Care.
The closest grocery stores are Mini Market El Milagro, Seattle Sutton's Healthy Eating and Whipple Grocery.
Nearby coffee shops include J Story, Organo Gold Coffee and Starbucks. There are 71 restaurants within a 15 minute walk including Angelo's Pizza & Restaurant, Mi Rancho and Mr Pollo.
4410 North Sacramento Avenue is near Buffalo Park, Ravenswood Manor Park and Jacob Park.
There are some bike lanes and the terrain is flat as a pancake. 4410 North Sacramento Avenue is bikeable, there is some bike infrastructure.
Explore how far you can travel by car, bus, bike and foot from 4410 North Sacramento Avenue.
4410 North Sacramento Avenue has good transit which means many nearby public transportation options. Car sharing is available from RelayRides, Zipcar, I-GO and Getaround.
Rail lines:
Brown Line
0.3 mi
Blue Line
1.3 mi
UP-NW Union Pacific Northwest
1.5 mi
Bus lines:
78 Montrose
0.0 mi
81 Lawrence
0.5 mi
82 Kimball-Homan
0.5 mi
80 Irving Park
0.5 mi
Car shares:
4410 North Sacramento Avenue compared to all of Chicago.
Lower crime area.
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4410 North Sacramento Avenue is in the Albany Park neighborhood. Albany Park is the 52nd most walkable neighborhood in Chicago with a neighborhood Walk Score of 85.
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text:
Robot orders surge as vehicle output climbs
12:01 am U.S. ET | Feb. 23, 2015
In a bid to keep pace with rising production, automakers and suppliers are ordering record numbers of robots. Last year, companies ordered 17,678 automotive robots in North America, up 45 percent from 2013, said the Robotic Industries Association. Manufacturers are hustling to boost output now that annual North American light-vehicle production is topping 17 million units....
VW hit by labor, tech problems in push for top spot
Sept. 27, 2014 06:01 CET
VW Group's quest to be the world's top-selling automaker is being threatened by a host of problems at its massive Wolfsburg plant that include strained labor relations, spiraling costs and technical problems with production....
N.A. robot sales poised for record
12:01 am U.S. ET | Sept. 15, 2014
A bumper crop of North American vehicle launches this year has triggered what is shaping up as a record wave of robot purchases by automakers and suppliers....
Standardized robotic stations can improve quality as lightweight materials gain favor, exec says
1:10 pm U.S. ET | Aug. 4, 2014
Automakers' rapid embrace of lightweight materials will dramatically increases manufacturing complexity that can be solved with automation and standardization, says Martin Kinsella, director of advanced materials and process technology for Comau....
Robotics suppliers post record business in North America
3:29 pm U.S. ET | July 29, 2014
Robotics suppliers, paced by automakers preparing for new-product launches, posted records for orders in North America during the second quarter and first half of the year, an industry trade group reported today....
Toyota's future manufacturing plans see humans replacing robots
2:33 pm U.S. ET | April 7, 2014
Toyota's next step forward in manufacturing is counter-intuitive in an age of automation: Humans are taking the place of machines in plants across Japan so workers can develop new skills and figure out ways to improve production lines and the car-building process....
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House lawmakers question TSA process that funnels high-risk travelers through PreCheck
A Transportation Security Administration official said the agency is ramping up marketing to enroll more eligible low-risk travelers who pay to go through an expedited screening program, but will continue to use a process that ferries higher-risk travelers through that same security checkpoint.
Sea-level rise from climate change will threaten Hawaii's shoreline communities, new study says
If climate change continues as predicted, rising sea levels would double Hawaii's coastal erosion by mid-century, leading to beach loss, damage to homes and infrastructure, and endangerment to critical habitats, a new study predicts.
DHS's No. 2 Mayorkas under fire for giving preferential treatment to foreign investors following IG probe
In three instances, the Homeland Security Department's second-in-command used "improper influence" to help foreign investors obtain necessary permanent residency in the United States, an internal investigation concluded March 24.
DHS IG confirms whistleblower allegations that some border patrol agents abused overtime pay
Through four separate reports, the Homeland Security Department's watchdog said it's confirmed allegations from whistleblowers about widespread misuse of "administratively uncontrollable overtime" by some U.S. border patrol agents.
DHS issues draft guidance for disaster information sharing following earthquake exercise
The guidance lays out Essential Elements of Information to be shared in response to a disaster, as well as instruction on how to publish and receive alerts from the Integrated Public Alert and Warning System and share geospatial information.
UK researchers craft economic methodology that outlines business losses from climate change
Researchers at a U.K. university said a methodology they developed for a social housing provider, outlining the "true" business costs from the impact of climate change, is also applicable to other organizations.
House bill would widen Visa Waiver Program despite concerns of intelligence gaps
The bill would expand the program that permits visitors from certain participating countries to enter the country without a visa as a way to boost tourism in the United States, but some have fears that the program could also potentially admit terrorists.
TSA improperly provided 'notorious' convicted felon expedited screening at airport, DHS IG finds
A convicted felon who was also a former member of a domestic terrorist group was allowed by the Transportation Security Administration to go through the expedited passenger screening lane at an airport last year even after a security officer recognized the "notorious" traveler.
DHS helping communities assess, prepare for chemical attacks, says official
The threat of chemical attacks against U.S. communities is different based on an individual community's risk, a Homeland Security Department official said during a House hearing March 19.
GAO: Oversight of some major DHS programs' cost and performance lacking
The Government Accountability Office said DHS has improved certain aspects of its acquisition management process in recent years, which is important to make sure that programs are living up to their promise.
ACLU, NY affiliate sue TSA for records related to passenger behavior screening program
At issue is the Screening of Passengers by Observation Techniques, which uses behavior detection officers to detect passenger behaviors that may be indicative of stress, fear or deception.
Destruction of thousands of chemical weapons at Army depot in Colorado begins this week
Eventually, the entire stockpile of 780,000 munitions containing more than 2,600 tons of mustard agent will be destroyed at the Pueblo Chemical Agent-Destruction Pilot Plant, using a process called neutralization followed by biotreatment.
US, Canada announce new agreement to boost preclearance inspections of travelers
Canadian and U.S. government officials announced March 16 a new agreement that allows federal agencies to conduct immigration, customs and agriculture inspections in each other's countries while facilitating travel.
NASA plans satellite mission to study phytoplankton, airborne particles and climate impact
The Pre-Aersol Clouds and ocean Ecosystem, or PACE, mission will study the Earth's oceans and atmosphere and learn more about the role of marine phytoplanton – which are microscopic ocean algae – in the global carbon cycle.
CBP addresses problems in examining high-risk rail shipments from Canada, Mexico, IG says
United States customs officers didn't always effectively use certain critera to assess the risk of some rail shipments entering from Canada and Mexico nor did some use required radiation detection equipment to examine high-risk cargo – problems that have since been addressed.
Coast Guard needs to better ensure the quality of biometric data it sends to DHS, IG says
The DHS inspector general's audit found that the Coast Guard does not consistently reconcile the data it collects through its Biometrics At Sea System with what it provides to DHS's Automated Biometric Identification System.
DHS's Brothers tweets about science and tech projects, goals
Reginald Brothers, who heads the Homeland Security Department's research and development arm, took to Twitter March 1, answering questions ranging from cybersecurity and airport security to the Islamic State.
Initial strategy to lessen severity, size and impact of wildfires released by Interior Department
The increasing acceleration of non-native annual grasses coupled with drought and effects of climate change have increased the wildfire threat to the sagebrush landscape and more than 350 species of plants and animals.
DHS seeks to speed up development of emerging wearable technology for first responders
The department's Science and Technology Directorate launched its first business accelerator program called "EMERGE!" that will provide early-market validation, mentoring and access to private investment for certain technologies.
New paper describes Islamic State's political, religious beliefs and their historical context
While it appears the Islamic State emerged within the last two years, the hardline terrorist group has been around for almost a decade. And leaders of the terrorist group have been broadcasting their ideology for just as long.


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What say you??
I have not used the other blade yet.
SO-5 years together-he decided to end it by cheating too
me (WW/BS): 48
him: (BS/WH)52
4 kiddos in mid 20's
Take action to change what needs changing. Take action to respond to your situation. Let the discouragement take ca


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Order your NX®, Origins Café and Fine Tea capsules in a few simple steps
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Brisbane, Australia
This interactive workshop demonstrates how to create accessible documents using Microsoft Office and Adobe Acrobat Pro. On completion of the workshop attendees will know how to create PDF documents to WCAG 2.0 Double A compliance, and Microsoft Office documents that are fully optimised for accessibility. Assistive technology demonstrations and videos help attendees understand the experiences of end-users.For more information: website


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I am 5 weeks pregnant and I am slightly worried about who the father could be. The doctor told me I conceived about the 14th of March. Is it possible to get pregnant the day of having sex or does it typically take a couple days? I was under the impression "conception" meant the day you had sex and got pregnant.
Posted: 04/10/2012 by a BabyCenter Member
Mom Answers
Sort by: best answers | most recent answers
1 - 10 of 36 answers
When you have sex, sperm are released up into the uterus and Fallopian tube. If you happen to have sex on the same day as you have ovulates, then you could get pregnant the same day. But if you don't ovulate the same day you have sex, sperm can live for up to three days (some day even longer!). So you can get pregnant 1,2 and even 3 days after you have sex. It all comes down to when you ovulate and if there are sperm hanging around or not! The egg only lives for about a day so it's not hanging around as long as the sperm are. Conception means the day the sperm fertilized the egg. Which could be on the same day you had sex or up to 3 days later. Hope that helps!posted 04/10/2012 by a BabyCenter Member
Sperm can remain the body up to 72 hrs. So you can conceive the day you had sex or the egg can be fertilized up to a few days after you have sex.posted 04/10/2012 by a BabyCenter Member
For the ladies that are trying to get pregnant; what I did was: after having sex before I cleaned myself up, I flipped upside down on my bed so my legs were on the wall & I just layed like that for 10-15 minutes & I conceived my daughter!! Sometimes it just needs help traveling up there.posted 06/15/2014 by abarzua21
to be honest I have no idea how long it takes. I was overseas when my girlfriend found out she was pregnant. and not to be rude but reading the other comments people are saying they slept with one guy then another right after. if you want to be sure who the father is pick one guy and stick with him. not bang one guy one day and another a few days later.posted 10/18/2013 by 1stLieutenantJCraig
i had intamicy on Monday 8-9 & Tuesday 8-10 and this is my ovulating week.. when will be a good time to take a pregnancy test?posted 08/16/2013 by a BabyCenter Member
fellow women - HAVE SEX WITH JUST ONE GUY TO AVOID HEADACHES! STOP CHEATING YOUR PARTNER THEN FEEL BAD WHO THE FATHER IS!posted 12/19/2014 by a BabyCenter Member
Can you get in pergnant in 24 hourposted 02/14/2015 by nahedabegum2010
I had sex the 11th of December and the last week of December and was due september 20th! I was confused on my baby's father. So the doctor told me the father would more than possibly be the guy the last week of December. But according to the the paternity test my baby belonged to the guy I slept with the 11th. My doctor then explained to me that on the 11th the sperm was released in me and survived up until I ovulated which was 3 days later so some conception calculators can be offposted 01/30/2015 by a BabyCenter Member
is it possible to get pregnant,if you have sex while you have your periodsposted 01/08/2015 by taengdi09
There was a woman i was dealing with, and she was having intercourse with anotheher guy in october i dont knw when. that mean she had just broke up with her ex, She came to me i ejaculated in her on the 17th of november 2013. I want to knw is is my kid all now the kid born. What do you think?"posted 12/11/2014 by ghostdawggy
Answer this question


text: Quick View Abraham: The World's First (but Certainly Not… by Alan M. Dershowitz October 6, 2015 | Hardcover Pre-order online from $21.32 Attorney and bestselling author Alan M. Dershowitz was first in his class at Yale Law School. Dershowitz was editor-in-chief of the Yale Law Journal and the youngest full professor in the history of Harvard Law School. He is currently the Felix Frankfurter Professor of Law at Harvard University.… See Details $22.44 / $21.32 lowest price*was $34.00


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Tags fok/rock, indie rock, israeli rock, israeli folk rock
Genres rock, israeli, alternative, israel, progressive rock (beta)
(flag as incorrect)
Artists Oren Barzilay, The Walking Man, Uzi Ramirez (beta)
September 24, 2011
100% Israeli indie rock bands tunes in English
אוהבת את זה
מוזיקה ישראלית היא הטובה ביותר
סחטיין, אבל מה עם הפלייליסטים שלך?
בקרוב (:
can I hear these in hebrew?
try to google the bands name and you'll find some of their songs in hebrew.
I am a fellow Israeli too! Great mixes :D You have good music taste! it's nice to see another Israeli on here. Please check out my mixes, im fairly new!
WELCOME JUNE by amironhz
Welcoming June with a new alternative & indie summer mix.
indie, alternative rock, summer, happy, house party
Smooth & Electric by amironhz
Smooth & Electric sound for your ears.
smooth, chill-, latenightsounds, electronic
Thats how its done in Orange County by amironhz
A tribute to one of the best indie soundtrack (The OC ost).
the oc, indie rock, indie, pop, rock
Let's Have Some Fun by amironhz
As the title says.
happy, fun, indie rock, rock, indie


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Oh, and the reason I care about the difference is that I use a sensitometer to speed rate my film.
Then I use Zone System metering technique.
So I want to know the difference, if it is a whole stop or two thirds of a stop. Or if the difference "depends" on the chosen gradient (I use Contrast Index).


text: In the Garden: Where to get reliable information for houseplant care Houseplant information is easier to find than ever before with the resources available on the Internet. Some sources of information are more reliable than others and the end of a website address often offers a clue. I'll explain briefly. 4 months ago


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Soaps.com wants to take a moment to remember Daytime Emmy Award winner and producer Robert Calhoun, who passed away on May 24, 2008 at the age of 77 due to lung cancer.
Born in Brooklyn, New York, Robert graduated from the University of Maryland then went on to serve three years in the US Navy. Although he began working in theater, Robert left his mark in daytime over a number of successful years. Starting off as a director on... » Read More


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Date: 1884
Description: Sanborn-Perris fire insurance map for city of Menasha.
Date: 1893 ca.
Description: Elevated view of the Northern Hospital for the Insane and its front grounds.
Date: 1897
Description: This 1897 map of Winnebago County, Wisconsin, shows the township and range grid, towns, sections, cities and villages, landownership and acreages, rural re...
Date: 1846 ca.
Description: This plat map, which features the very early spelling of Wisconsin as "Wiskonsin", was created sometime between 1846 and 1854 and shows a canal and dam on...
Date: 1887
Description: Sanborn-Perris fire insurance maps for city of Menasha.
Date: 1858-01-01
Description: Printed invitation to a New Year's Ball given at Weeden's Hotel in Neenah with music provided by Shattuck's Cotillion Band. The invitation is printed on e...
Date: 1875 ca.
Description: Looking across Winneconne towards the bridge from the east side of town.
Date: 1878
Description: Carte-de-visite of a studio portrait of two girls posed in a small "boat" in front of a painted backdrop. They are wearing fancy dresses, and one girl hold...
Description: Locomotive No. 75. Class H. Built 1850 by Schnectady Locomotive Works. Men are posed on and around the locomotive.
Description: Six beds in the sleeping quarters of the Northern Hospital for the Insane.
Date: 1870 ca.
Description: Stereoview of the town.
Date: 1877
Description: Group portrait in front of the Immanuel Norwegian Evangelical Lutheran Church parsonage and part of a series taken during the meeting of the Eastern Distri...
Date: 1890 ca.
Description: Mound known as the Hill of the Dead.
Description: A view of Oshkosh from a river.
Date: 1891
Description: Presbyterian church (old church).
Date: 1868
Description: The Philteus Sawyer residence located on the northwest corner of Algoma and West Algoma Streets. Sawyer was mayor of Oshkosh from 1863-1864, and became a U...
Date: 1890
Description: Cabinet card of an informal full-length portrait. (Mrs. Ben) Jessie Jack Hooper relaxes in a chair. The portrait may have been taken at the Sawyer House in...
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Pantyhose, confused by terms.
So sorry for all the fashion questions.
Need pantyhose for the "cowboy" wedding if you have read the other posts. I am confused by the terms and the more I look at supposed fashion expert web sites the more confused I become.
Don't want black, want legs to look bare. Need some coverage for a few varicose veins. Try to match my actual color or slightly darker? Then the terms opaque, sheer, matte, etc. are confusing. I don't want the hose to compete with the dress which has a little shimmer or the boots. The boots are kind of low on my leg and the dress hem is above the knee. What are good brands or places to buy hose?
The question of pantyhose has been a tough one for me, too. At 55, my legs aren't what they used to be and I have some obvious veins. I wore pantyhose to the office for most of my career (I'm in a much more casual office now), and I find it almost impossible to be comfortable in a knee-length skirt without them. In the winter, my go-to option is always opaque black tights with boots or shoes, but always choose a mid calf or longer skirt in summer.
However, earlier this summer I splurged before going on vacation and got a spray (airbrush?) tan. My legs looked great instantly! It does wear off after about a week and isn't something I'd do on a regular basis, but you might consider it for your event. You'd want to do it a day or two before, so there isn't any chance of staining your dress, but it's a good alternative to pantyhose. I went to a Benefit Cosmetics boutique, but I've seen it advertised at hair salons near my office in Greenwich, CT with prices from $45 (what I paid) to as much as $85. Mine was done by a technician with what looked like a paint sprayer -- she was very accurate -- and there were different levels of color. You could also just have your legs done.
Just an option, considering it is almost impossible to find pantyhose in stores anymore!
I would not wear hose with a dress worn with western boots. You are wearing cowboy boots - do I remember that correctly? I would do what home suggested or just bare skin before wearing hose.
Any roughness on any edge of the boot can snag or run the panty hose. So if you do decide to wear them, better bring a spare too.
If you are looking for nude hose, go to a dept store liked lord and Taylor, go to a hosiery store like l'eggs/Hanes, or even try a drug store chain like cvs or walgreens.
I do go UV tanning now and plan to do it a lot more in the next few weeks. While it does help my legs look better it doesn't help the bulging veins. There would be too much skin showing to be comfortable for me without pantyhose. Bringing along an extra pair of hose is a good idea.
Here is the dress, boots, and jewelry. Should the pantyhose be matte or not? The dress has a little shimmer to it.
When Kate toured Canada with Prince William, she wore hose with a wee bit of shimmer and it was all the rage. A little shimmer would be nice for a wedding and might help disguise the veins. Of course, no one will be looking at your legs!
Would you wear a little sock between hose and boot for comfort and to stop snags?
I'd consider a sheer black pantyhose with shimmer to go with that outfit. I like Hanes, too and buy them at Macy's. They come in all shades. The control top type seem to give more leg coverage too, to hide the veins. They come in all colors, so match your skin color if you want nude.
I can't remember the last time I wore pantyhose. Probably the last day I worked.
For summer, I would go with nude sheer maybe with shimmer. For winter, I would go with all black.
I used to buy some nice sheer Hanes from department stores. But buy an extra pair because they were delicate. The name came to me: Hanes Silk Reflections.
This post was edited by gsciencechick on Sun, Aug 10, 14 at 20:13
I know UV tanning is not very healthy but I do look better with it. I only do a few minutes at a time as I feel claustrophobic in the booth. I have tried spray tanning and was told by my family that it makes me look old as it wears off (I agree). Spray tanning is also very expensive here.
I will go shopping soon for the hose. I will try JCP & Macy's. I will look for Hanes Silk Reflections.
In June I spent 30 min. in Kohl's looking for pantyhose and came home with a pair that didn't fit well (was too big) and did not have a good feel.
On a side note, those boots have now inspired us to have the DJ play Nancy Sinatra's These boots are made for walkin' and have all the women dance. We are all watching the youtube video and practicing. OH those moves are hard! Some I will never be able to do.
Thank you all for the help!


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