text:
A fluid dispensing device for dispensing a fluid product having a dispensing outlet from which the fluid product is dispensable, a supply of the fluid product, a dispensing member mounted for movement in a dispensing direction along an axis X-X from a first position to a second position which causes a dose of the fluid product in the supply to be dispensed from the dispensing outlet, and a finger-operable actuator member mounted for movement in an actuating direction which is generally transverse to the axis.
1. A fluid dispensing device for dispensing a fluid product having:
a dispensing outlet from which the fluid product is dispensable,
a supply of the fluid product,
a dispensing member mounted for movement in an upward, dispensing direction along an axis from a first position to a second position which causes a dose of the fluid product in the supply to be dispensed from the dispensing outlet, and
a finger-operable actuator member mounted for pivotal movement about a lower end of the actuator member in an actuating direction which is generally transverse to the axis,
wherein the actuator member has at least one cam surface remote from the lower end and the dispensing member has at least one cam follower surface,
wherein the actuator member is pivotally movable in the actuating direction to cause the at least one cam surface to bear against the at least one cam follower surface to force the at least one cam follower surface to ride over the cam surface to cam the dispensing member in the upward, dispensing direction from the first position to the second position,
wherein the at least one cam surface has a commitment section, oriented at a first angle to the axis, and an adjacent drive section, which is oriented at a second angle to the axis which is greater than the first angle,
wherein the device is configured and arranged such that, in use, the at least one cam follower surface successively rides upward over the commitment and drive sections of the at least one cam surface, on pivotal movement of the actuator member in the actuating direction, to cam the dispensing member from the first position to the second position,
wherein the first angle is selected such that a minimum actuating force is required to be applied to the actuator member to cause the at least one cam follower surface to ride upward over the commitment section onto the drive section, and
wherein the drive section of the at least one cam surface is a convex section.
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This application is filed pursuant to 35 U.S.C. §371 as a United States National Phase Application of International Patent Application Serial No. PCT/GB2005/000944 filed Mar. 10, 2005, which claims priority from Great Britain Application No. 0405477.1 filed in the United Kingdom on Mar. 11, 2004, the content of which is incorporated herein by reference.
The present invention relates to a fluid dispensing device for dispensing a fluid product, for instance a medicament, and is particularly, but not exclusively, concerned with an intra-nasal dispensing device.
It is well known to provide a fluid dispenser in which fluid is dispensed via a nozzle or orifice upon the application of a force by a user to a pump dispenser. Such devices are generally arranged with a reservoir containing several doses of a fluid formulation to be dispensed by sequential metered pump actuations. An example of a pump action spray is shown and described in U.S. Pat. No. 4,946,069.
A hand-held, manually-operable intra-nasal fluid medicament dispenser is disclosed in WO-A-03/095007, the entire content of which is hereby incorporated herein by reference. The dispenser has a housing which houses a fluid discharge device having a compression pump mounted on a container which contains the medicament. The housing has at least one finger-operable side lever which is movable inwardly with respect to the housing to cam the container upwardly in the housing to cause the pump to compress and pump a dose of the medicament out of a pump stem through a nasal nozzle of the housing. In an embodiment shown in
The aim of the present invention is to provide improvements to fluid dispensing devices, in particular those for intra-nasal use and/or those operated with side-actuators.
According to the present invention there is provided a fluid dispensing device according to claim 1 hereof, a fluid dispensing device according to claim 30 hereof, a fluid dispensing device according to claim 37 hereof, a fluid dispenser according to claim 42 hereof, a set according to claim 48 hereof, and a fluid dispenser according to claim 52 hereof.
Useful features of the invention are set forth in the other claims hereof.
The term "finger-operable" means operable by action of the finger or thumb, or combinations thereof, of a typical user (e.g. an adult or child patient).
Typically, the minimum actuating force is in the range from 5 to 45N, such as from 5 to 30N, for example, in the range of about 25 to 40N, for instance in the range of 20 to 45N, more typically from 10 to 25N. Such values tend to correspond to a force which presents a suitable 'barrier force' to a weak, nondescript or unintended finger movement whilst readily being overcome by the determined finger (or thumb) action of a user. It will be appreciated that if the device is designed for use by a child or elderly patient it may have a lower minimum actuating force than that designed for adult usage.
Ideally, particularly for medicinal use, the dispenser of the invention dispenses metered doses of the fluid product.
Ideally, the dispenser is configured and arranged to dispense each dose of the fluid product as an atomised spray.
Suitably, the fluid dispenser of the invention incorporates a pump to pump the fluid product dose from the dispenser. The pump may comprise a pre-compression pump, such as the VP3 or VP7 model, or a modified version thereof, manufactured by Valois SA. Typically, such pre-compression pumps are typically used with a bottle (glass or plastic) container capable of holding 8-50 ml of a fluid product. Each actuation will typically deliver 25-150 μl, particularly 50-100 μl, of the fluid product (i.e. a metered dose) and the device is therefore typically capable of providing at least 50 (e.g. 60 or 100) metered doses.
Other suitable dispensing containers include those sold by Erich Pfeiffer GmbH, Rexam-Sofab and Saint-Cobain Calmar GmbH.
For the avoidance of doubt, the various aspects of the invention can be modified to incorporate the other aspects or one or more features of the other aspects.
Further aspects and features of the invention are set forth in the following description of an exemplary embodiment of the invention made with reference to the accompanying drawings.
The fluid dispensing device 1405 comprises a plastics housing 1409 (e.g. of ABS), a nozzle 1411 for insertion into the nasal cavity at an upper end of the housing 1409 and a fluid discharge device 1408 housed within the housing 1409 for reciprocal translation along its longitudinal axis X-X. As shown in
The outer surface, or a part of the outer surface, of the nozzle 1411 can be made from a soft-touch plastics material. However, in this embodiment the nozzle 1411 is made from polypropylene (PP).
The fluid discharge device 1408 comprises a container 1430, for storing enough of the fluid for multiple metered doses thereof to be dispensed, and a compression pump 1429 mounted on the container 1430. The container 1430 is made from a translucent or transparent plastics material, although it will be apparent that it could be made from other translucent or transparent materials, such as glass. The pump 1429 has a suction inlet 1461, in the form of a dip tube, located within the container 1430 and a discharge outlet 1463, in the form of a pump stem, for transferring fluid from the pump 1429 to the nozzle 1411.
The housing 1409 is provided with a window 1450 through which the level of the fluid in the container 1430 can be checked.
Pivotally mounted to the housing is a finger operable means 1420 to apply a force to the container 1430 in a direction which is transverse to the longitudinal axis X-X. This transverse force moves the container 1430 towards the nozzle 1411 along the longitudinal axis X-X so as to actuate the pump 1429. The finger operable means is in the form of a lever 1420 (e.g. of ABS) pivotally connected at its lower end to the housing 1409 and arranged to act upon the container 1430 so as to urge the container 1430 towards the nozzle 1411 when the lever 1420 is pivoted inwardly by a user's finger or thumb.
A protective end cap 1407 is provided for protection of the nozzle 1411. First and second lugs 1449 a, 1449 b project from the protective end cap 1407 for receipt within suitably arranged channels 1451 a, 1451 b provided within the housing 1409 such as to allow secure attachment of the end cap 1407 to the housing 1409. When so-received, first lug 1449 a further interferes with movement of lever 1420 such as to prevent actuation (i.e. to lock movement) of the lever 1420 when the end cap 1407 and lugs 1449 a, 1449 b are in place (i.e. in the nozzle covered position).
The end cap 1407 also has a protruding stopper 1460 which has a convex, resilient end form 1461 arranged for sealing engagement with the dispensing orifice 1415 of the nozzle 1411 so as provide an essentially airtight seal to nozzle orifice 1415 to prevent fluid drain back when the stopper 1460 is in place.
The end cap is suitably made from the same material as the housing, e.g. a plastics material, suitably ABS.
As will be understood by reference to
In more detail, the beaks 1421 are located at the upper end of the lever 1420 on opposite sides thereof. In plan view, the upper end of the lever 1420 has a U-shaped cross section, as shown in
Each cam surface 1422 of the lever 1420 has a variable mechanical ratio arranged such that until a pre-determined force is applied to the lever 1420 no significant force is transferred to the container 1430. In more detail, each cam surface 1422 has a commitment portion 1423 a which is inclined at a first angle to the longitudinal axis X-X of the fluid discharge device 1408 and a drive portion 1423 b inclined to the longitudinal axis X-X at a second angle which is greater than the first angle. The first angle should be no less than approximately 20°, and is suitably in the range of approximately 20-35°, more suitably approx. 20-26°, even more suitably approx. 22-26°. The second angle may be in the range of approximately 40-60°, suitably approx. 40-50°, more suitably approx. 45°.
Therefore, when an inward force is initially applied to the lever 1420 it is applied substantially normally to the longitudinal axis X-X of the fluid discharge device 1408 and virtually no force is converted into a force along the longitudinal axis X-X of the fluid discharge device 1408 and so the static friction between the commitment portions 1423 a of the beaks 1421 and the cam follower surfaces 1492 is sufficient to maintain the lever 1420 effectively stationary. However, when a pre-determined load is applied to the lever 1420 the static friction is overcome and the cam follower surfaces 1492 start riding on the commitment portions 1423 a.
When the cam follower surfaces 1492 reach the end of the commitment portions 1423 a, the increase in inclination of the cam surfaces to the longitudinal axis X-X in combination with the magnitude of the force being applied ensures that the cam follower surfaces 1490 suddenly slide rapidly along the drive portions 1423 b causing the container 1430 to be moved rapidly towards the nozzle 1411 to actuate the compression pump. This ensures that the pump is only actuated when sufficient force is being applied to guarantee the production of an effective spray from the nozzle 1411.
Referring to
R1 in this embodiment is about 3 mm, while R2 is about 25 mm. Nonetheless, other radii could be used, as will be appreciated by the skilled person in the art. For example, the transition portion may have a radius of curvature in the range of about 1-5 mm. In still further embodiments, the second portion may have a radius of curvature in the range of about 15-40 mm.
Referring to
As shown in
Noting that the lever 1420 pivots inwardly, it will be appreciated that as the lever 1420 pivots inwardly the inclined angle which the planar commitment portions 1423 a make with the longitudinal axis X-X becomes smaller (steeper) thereby increasing the resistance of the fluid discharge device 1408 to being cammed upwardly.
However, the arcuate nature of the drive portions 1423 b, in particular that part after the transition section 1423 c, is such that the inclined angle it makes with the longitudinal axis X-X remains the same, or substantially the same, as the lever 1420 pivots inwardly. More specifically, consider that as the lever 1420 pivots inwardly the point on the section of the drive portion 1423 b having the radius of curvature R2 which is in contact with the cam follower surface 1492 moves up the cam surface 1422. The angle that a tangent to this changing contact point makes with the longitudinal axis X-X remains the same, or substantially the same, as the lever 1420 pivots inwardly to cause the fluid discharge device 1408 to spray a metered dose of the fluid product from the nozzle 1411. This feature means that the resistance to the inward movement of the lever 1420 never increases after the commitment feature has been overcome, as would be the case if the drive portion 1423 b were a planar surface since its angle to the longitudinal axis X-X would then increase as the lever 1420 pivots inwardly.
The aforementioned features of the cam profile mean that the operator receives smooth tactile feedback from the device 1405 when the lever 1420 is actuated to cause the fluid discharge device 1408 to spray a metered dose of the fluid product from the nozzle 1411.
To use the fluid dispensing device 1405 a user first has to remove the protective cap 1407 thereby unsealing the nozzle orifice 1415 by removing the stopper end 1460 therefrom. The user then grasps the fluid dispensing device 1405 and places a thumb and/or finger on the lever 1420.
Provided that only a light pressure is applied to the lever 1420 no fluid will be discharged and the user is able to manoeuvre the dispensing nozzle 1411 of the fluid dispensing device 1405 into one of their nostrils so that the fluid is able to be dispensed into the nasal cavity.
If the user then squeezes the lever 1420 inwards with increasing force the threshold force defined by the interaction of the cam follower surfaces 1492 with the commitment portions 1423 a of the cam surfaces 1422 is overcome resulting in the container 1430 being moved rapidly towards the nozzle 1411 to actuate the pump 1429 and dispense fluid to the dispensing orifice 1415. Upon release of the pressure applied to the lever 1420 the pump is reset by its internal return spring. Moreover, the lever 1420 has a leaf spring 1465 (
The actuating procedure can then be repeated until all of the fluid in the container 1430 has been used. However, only one or two doses of fluid are normally administered at a time.
Referring to
In use, the tracks 1469 ride on the runners 1467 when the lever 1420 overcomes the threshold force provided by the commitment portions 1423 a of the cam surfaces 1422. As will be appreciated, the co-operation of the tracks 1469 with the runners 1467 prevents rotation of the collar 1490 in the housing 1409.
In addition to the tracks 1469, the collar also has a sheath 1473 for the pump stem 1463 which forms a sliding fit on an inner hollow post 1475 of the nozzle 1411 in which a nozzle outlet passage 1477 is formed. As shown in
As shown in
In addition, having a separate nozzle 1411 means that the housing 1409 can be customised for different markets and/or different products. As an example, the nozzle 1411 could be a universal nozzle for a set of housings having different shapes, different colours, etc.
A further advantage of a separate nozzle 1411 is that it can be more easily formed from a different material than the housing 1409, for example one that is more acceptable for insertion into a nostril and/or for contacting the fluid product, especially where this is a medicament, but which might be too expensive to form the whole housing 1409 from.
To this end, and as shown in
To assist in assembly of the fluid dispensing device 1405, the lever 1420 is provided with means to enable it to be disposed in an outward position with respect to the housing 1409, to allow the fluid discharge device 1408 to be inserted into the housing 1409 through the lower opening 1471 to its rest position shown in
Referring to
As will be understood from
When the lever 1420 is in its outward position, the fluid discharge device 1408 is able to be inserted into the housing 1409 through the lower housing opening 1471 to its rest position because the lever 1420, and its beaks 1422 in particular, do not impede the loading of the fluid discharge device 1408.
After the fluid discharge device 1408 has been loaded to its rest position, the lever 1420 is moved to its inward position by depressing the tab 1501 so that it clears the edge of the slot 1507 and then pushing the lever 1420 inwardly to its position shown in
As shown in
In more detail, the tab 1501 bears against an inner surface of one of the channels 1451 a in the housing 1409 in which the cap lugs 1449 a, 1449 b are snap-fitted to hold the protective cap 1407 releasably captive on the housing 1409. As shown in
Those parts of the fluid dispensing device 1405 made from a plastics material are formed by a moulding process.
Other features of this exemplary embodiment are contained in the other sections of this specification, including, without limitation, the appended claims and statements in the 'Summary of the Invention' section supra.
The fluid discharge device 1408 may contain a medicament formulation, for example for the treatment of mild, moderate or severe acute or chronic symptoms or for prophylactic treatment. The precise dose administered will depend on the age and condition of the patient, the particular medicament used and the frequency of administration and will ultimately be at the discretion of the attendant physician. When combinations of medicaments are employed the dose of each component of the combination will in general be that employed for each component when used alone.
Appropriate medicaments may be selected from, for example, analgesics, e.g., codeine, dihydromorphine, ergotamine, fentanyl or morphine; anginal preparations, e.g., diltiazem; antiallergics, e.g., cromoglycate (eg as the sodium salt), ketotifen or nedocromil (eg as the sodium salt); antiinfectives e.g., cephalosporins, penicillins, streptomycin, sulphonamides, tetracyclines and pentamidine; antihistamines, e.g., methapyrilene; anti-inflammatories, e.g., beclomethasone (eg as the dipropionate ester), fluticasone (eg as the propionate ester), flunisolide, budesonide, rofleponide, mometasone (eg as the furoate ester), ciclesonide, triamcinolone (eg as the acetonide), 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-yl)ester or 6α,9α-Difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester; antitussives, e.g., noscapine; bronchodilators, e.g., albuterol (eg as free base or sulphate), salmeterol (eg as xinafoate), ephedrine, adrenaline, fenoterol (eg as hydrobromide), formoterol (eg as fumarate), isoprenaline, metaproterenol, phenylephrine, phenylpropanolamine, pirbuterol (eg as acetate), reproterol (eg as hydrochloride), rimiterol, terbutaline (eg as sulphate), isoetharine, tulobuterol or 4-hydroxy-7-[2-[[2-[[3-(2-phenylethoxy)propyl]sulfonyl]ethyl]amino]ethyl-2(3H)-benzothiazolone; PDE4 inhibitors eg cilomilast or roflumilast; leukotriene antagonists eg montelukast, pranlukast and zafirlukast; [adenosine 2a agonists, eg 2R,3R,4S,5R)-2-[6-Amino-2-(1S-hydroxymethyl-2-phenyl-ethylamino)-purin-9-yl]-5-(2-ethyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol (e.g. as maleate)]*; [α4 integrin inhibitors eg (2S)-3-[4-({[4-(aminocarbonyl)-1-piperidinyl]carbonyl}oxy)phenyl]-2-[((2S)-4-methyl-2-{[2-(2-methylphenoxy)acetyl]amino}pentanoyl)amino]propanoic acid (e.g as free acid or potassium salt)]*, diuretics, e.g., amiloride; anticholinergics, e.g., ipratropium (eg as bromide), tiotropium, atropine or oxitropium; hormones, e.g., cortisone, hydrocortisone or prednisolone; xanthines, e.g., aminophylline, choline theophyllinate, lysine theophyllinate or theophylline; therapeutic proteins and peptides, e.g., insulin or glucagons. It will be clear to a person skilled in the art that, where appropriate, the medicaments may be used in the form of salts, (e.g., as alkali metal or amine salts or as acid addition salts) or as esters (e.g., lower alkyl esters) or as solvates (e.g., hydrates) to optimise the activity and/or stability of the medicament and/or to minimise the solubility of the medicament in the propellant.
Preferably, the medicament is an anti-inflammatory compound for the treatment of inflammatory disorders or diseases such as asthma and rhinitis.
In one aspect, the medicament is a glucocorticoid compound, which has anti-inflammatory properties. One suitable glucocorticoid compound has the chemical name: 6α,9α-Difluoro-17α-(1-oxopropoxy)-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester (fluticasone propionate). Another suitable glucocorticoid compound has the chemical name: 6α,9α-difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester. A further suitable glucocorticoid compound has the chemical name: 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α-[(4-methyl-1,3-thiazole-5-carbonyl)oxy]-3-oxo-androsta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester.
Other suitable anti-inflammatory compounds include NSAIDs e.g. PDE4 inhibitors, leukotriene antagonists, iNOS inhibitors, tryptase and elastase inhibitors, beta-2 integrin antagonists and adenosine 2a agonists.
The medicament is formulated as any suitable fluid formulation, particularly a solution (e.g. aqueous) formulation or a suspension formulation, optionally containing other pharmaceutically acceptable additive components.
Suitably, the fluid medicament formulation herein has a viscosity of from 10 to 2000 mPa·s (10 to 2000 centipoise), particularly from 20 to 1000 mPa·s (20 to 1000 centipoise), such as from 50 to 1000 mPa·s (50 to 1000 centipoise) at 25° C.
Suitable formulations (e.g. solution or suspension) may be stabilised (e.g. using hydrochloric acid or sodium hydroxide) by appropriate selection of pH. Typically, the pH will be adjusted to between 4.5 and 7.5, preferably between 5.0 and 7.0, especially around 6 to 6.5.
Suitable formulations (e.g. solution or suspension) may comprise one or more excipients. By the term "excipient", herein, is meant substantially inert materials that are non-toxic and do not interact with other components of a composition in a deleterious manner including, but not limited to, pharmaceutical grades of carbohydrates, organic and inorganic salts, polymers, amino acids, phospholipids, wetting agents, emulsifiers, surfactants, poloxamers, pluronics, and ion exchange resins, and combinations thereof.
Suitable carbohydrates include monosaccharides include fructose; disaccharides, such as, but not limited to lactose, and combinations and derivatives thereof; polysaccharides, such as, but not limited to, cellulose and combinations and derivatives thereof; oligosaccharides, such as, but not limited to, dextrins, and combinations and derivatives thereof; polyols, such as but not limited to sorbitol, and combinations and derivatives thereof.
Suitable organic and inorganic salts include sodium or calcium phosphates, magnesium stearate, and combinations and derivatives thereof.
Suitable polymers include natural biodegradable protein polymers, including, but not limited to, gelatin and combinations and derivatives thereof; natural biodegradable polysaccharide polymers, including, but not limited to, chitin and starch, crosslinked starch and combinations and derivatives thereof; semi-synthetic biodegradable polymers, including, but not limited to, derivatives of chitosan; and synthetic biodegradable polymers, including, but not limited to, polyethylene glycols (PEG), polylactic acid (PLA), synthetic polymers including but not limited to polyvinyl alcohol and combinations and derivatives thereof;
Suitable amino acids include non-polar amino acids, such as leucine and combinations and derivatives thereof. Suitable phospholipids include lecithins and combinations and derivatives thereof.
Suitable wetting agents, surfactants and/or emulsifiers include gum acacia, cholesterol, fatty acids including combinations and derivatives thereof. Suitable poloxamers and/or Pluronics include poloxamer 188, Pluronic® F-108, and combinations and derivations thereof. Suitable ion exchange resins include amberlite IR120 and combinations and derivatives thereof;
Suitable solution formulations may comprise a solubilising agent such as a surfactant. Suitable surfactants include α-[4-(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxypoly(oxy-1,2-ethanediyl) polymers including those of the Triton series e.g. Triton X-100, Triton X-114 and Triton X-305 in which the X number is broadly indicative of the average number of ethoxy repeating units in the polymer (typically around 7-70, particularly around 7-30 especially around 7-10) and 4-(1,1,3,3-tetramethylbutyl)phenol polymers with formaldehyde and oxirane such as those having a relative molecular weight of 3500-5000 especially 4000-4700, particularly Tyloxapol. The surfactant is typically employed in a concentration of around 0.5-10%, preferably around 2-5% w/w based on weight of formulation.
Suitable solution formulations may also comprise hydroxyl containing is organic co-solvating agents include glycols such as polyethylene glycols (eg PEG 200) and propylene glycol; sugars such as dextrose; and ethanol. Dextrose and polyethylene glycol (eg PEG 200) are preferred, particularly dextrose. Propylene glycol is preferably used in an amount of no more than 20%, especially no more than 10% and is most preferably avoided altogether. Ethanol is preferably avoided. The hydroxyl containing organic co-solvating agents are typically employed at a concentration of 0.1-20% e.g. 0.5-10%, e.g. around 1-5% w/w based on weight of formulation.
Suitable solution formulations may also comprise solublising agents such as polysorbate, glycerine, benzyl alcohol, polyoxyethylene castor oils derivatives, polyethylene glycol and polyoxyethylene alkyl ethers (e.g. Cremophors, Brij).
Suitable solution formulations may also comprise one or more of the following components: viscosity enhancing agents; preservatives; and isotonicity adjusting agents.
Suitable viscosity enhancing agents include carboxymethylcellulose, veegum, tragacanth, bentonite, hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, poloxamers (eg. poloxamer 407), polyethylene glycols, alginates xanthym gums, carageenans and carbopols.
Suitable preservatives include quaternary ammonium compounds (e.g. benzalkonium chloride, benzethonium chloride, cetrimide and cetylpyridinium chloride), mercurial agents (e.g. phenylmercuric nitrate, phenylmercuric acetate and thimerosal), alcoholic agents (e.g. chlorobutanol, phenylethyl alcohol and benzyl alcohol), antibacterial esters (e.g. esters of para-hydroxybenzoic acid), chelating agents such as disodium edetate (EDTA) and other anti-microbial agents such as chlorhexidine, chlorocresol, sorbic acid and its salts and polymyxin.
Suitable isotonicity adjusting agents act such as to achieve isotonicity with body fluids (e.g. fluids of the nasal cavity), resulting in reduced levels of irritancy associated with many nasal formulations. Examples of suitable isotonicity adjusting agents are sodium chloride, dextrose and calcium chloride.
Suitable suspension formulations comprise an aqueous suspension of particulate medicament and optionally suspending agents, preservatives, wetting agents or isotonicity adjusting agents.
The particulate medicament suitably has a mass mean diameter (MMD) of less than 20 μm, preferably between 0.5-10 μm, especially between 1-5 μm. If particle size reduction is necessary, this may be achieved by techniques such as micronisation and/or microfluidisation.
Suitable suspending agents include carboxymethylcellulose, veegum, tragacanth, bentonite, methylcellulose and polyethylene glycols.
Suitable wetting agents function to wet the particles of medicament to facilitate dispersion thereof in the aqueous phase of the composition.
Examples of wetting agents that can be used are fatty alcohols, esters and ethers. Preferably, the wetting agent is a hydrophilic, non-ionic surfactant, most preferably polyoxyethylene (20) sorbitan monooleate (supplied as the branded product Polysorbate 80).
Suitable preservatives and isotonicity adjusting agents are as described above in relation to solution formulations.
The dispensing device herein is suitable for dispensing fluid medicament formulations for the treatment of inflammatory and/or allergic conditions of the nasal passages such as rhinitis e.g. seasonal and perennial rhinitis as well as other local inflammatory conditions such as asthma, COPD and dermatitis.
A suitable dosing regime would be for the patient to inhale slowly through the nose subsequent to the nasal cavity being cleared. During inhalation the formulation would be applied to one nostril while the other is manually compressed. This procedure would then be repeated for the other nostril. Typically, one or two inhalations per nostril would be administered by the above procedure up to three times each day, ideally once daily. Each dose, for example, may deliver 5 μg, 50 μg, 100 μg, 204 μg or 250 μg of active medicament. The precise dosage is either known or readily ascertainable by those skilled in the art.
It will be understood that the present disclosure is for the purpose of illustration only and the invention extends to modifications, variations and improvements thereto.
All usage herein of terms such as "about", "approximately", "substantially" and the like in relation to a parameter or property is meant to include the exact parameter or property as well as immaterial deviations therefrom.
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With Bracebridge facing at least $26 million in road and bridge repair costs over the next decade, Mayor Graydon Smith is questioning whether some of the needed money should be borrowed.
Smith raised the question at a special general committee meeting on Wednesday, Jan. 9, where Bill Van Ryn of the C.C. Tatham and Associates engineering firm tabled an extensive audit of the town's most decrepit and under-maintained roads. Saying that the $4.9 million needed for bridge repairs over the next 10 years is already outside the scope of the town's capital capabilities, Smith asked that new methods of funding be considered.
"It makes me question whether or not it would be appropriate to debenture some of the costs of these works," Smith said. "I know that is rarely done when you're talking road or bridge works, but money being cheap these days, and thankfully our debt level being low, (I'd) certainly like to see some analysis on that."
Smith said he was hoping for a "clearer plan" to address road and bridge repair issues that keep dogging councillors and staff year after year.
"I'd hate to see us go through another cycle and not address that somehow or be cognizant of it somehow," he said.
Among the recommended bridge repairs, Van Ryn's report identifies 80 deficiencies on 19 structures, which range from rough riding surfaces and pedestrian or vehicular hazards to problems with their steel and concrete.
Three bridges – McCutcheon Bridge, Stephenson Townline Bridge and Goltz Lane Bridge – have been highlighted for immediate replacement.
Over the course of the past two years, councillors voted to replace the century-old McCutcheon Bridge in Vankoughnet with a steel bailey bridge. Town staff determined in 2011 that the single-lane structure, which carries Lambert Road over the Black River, was so weak it couldn't be expected to withstand a major flood. C.C. Tatham and Associates was commissioned to design the new bailey bridge in February 2012. The cost of replacing McCutcheon bridge was pegged at about $860,000.
After objections from area residents who feared the new bridge would encroach on the property of a nearby homeowner, town staff tweaked plans to reduce the intrusion from 13 to about seven metres. As of December 2012, staff are now hoping the town can save an additional $286,000 through applying for a fund from the Ministry of Agriculture, Food and Rural Affairs.
Goltz Lane Bridge, Van Ryn said, could be closed and not replaced as it "doesn't serve as anything other than as a shortcut right now." Showing councillors a photo of its dilapidated state, he said the load-bearing capability of the structure is questionable.
"The embankments are failing, there are steel beams underneath which have failed, you can put your hands through them," he said. "They have been twinned up with new steel, but … they are in pretty tough shape."
Bracebridge and Huntsville agreed last April to share the $80,000 cost of an environmental assessment for replacing the Stephenson Road 1 bridge.
Van Ryn's report says about $36 million is needed over the next decade for road repairs, but noted that amount could be trimmed to $22 million by deferring road widenings and improvements on low-volume roads.
Of the top 20 roads needing repairs, Van Ryn's report identifies a section of Quebec Street between Wellington and Victoria Streets as the top priority for repair work. A section of York Street between Taylor Road and Alice Street followed in second place, trailed by two sections of Douglas Drive between Manitoba Street and Gladys Street, and between Gladys Street and Clearbrook Trail. Edward Street, from Muskoka Road to its terminus, placed fifth.
Van Ryn pointed to Valley Drive, ranked 10th on the list, as an example of how badly roads have deteriorated.
"The asphalt's cracked. It's rutted. The shoulders are basically non-existent. The ditches are full of winter sand and culverts are shallow and squished and heaving in places," he said. "It's just ready for a tune-up."
In total, Van Ryn's report states that about 116 kilometres of the town's 317-kilometre road network – or about 36 per cent of roads – have deficiencies severe enough to warrant road improvement work. Deficiencies listed in the report range from surface condition problems to issues with structural condition and drainage.
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Oxygen-Safe SealingNovember 12, 2009 6:14 am IMPO
The MH052 pipe sealant from Permabond Engineering Adhesives (Somerset, NJ) has BAM approval for use in oxygen-rich environments (up to 145 psi and 140°F) due to its unique, stable formation. Normally, anaerobic sealants cannot be used in oxygen-rich environments due to instability, which could cause fire or explosions.
Slow Starts Save MoneyNovember 12, 2009 6:13 am
Carlo Gavazzi (Buffalo Grove, IL) has launched the RSBS Series Single-phase Plug-and-Play Soft Start, which reduces the amperage demand when starting heat pumps. By maintaining the starting current below fixed limits, the RSBS avoids high energy tariffs and reduces heat dissipation, allowing for a 60 percent reduction in current.
Steady, Stable Gas DeliveryNovember 12, 2009 6:13 am
Kin-Tek Laboratories, Inc. (Marque, TX) announces the 491M-PB Module, which is used with 491M Modular Gas Standards Generators to maintain steady gas pressures within the unit and balance backpressure to the delivery system pressure. At trace concentrations (PPM, PPB, and PPT) of reactive gases, surface absorption within the transport system can significantly affect the actual mixture delivered.
As Clear As GreaseNovember 12, 2009 6:12 am
Lubrication Engineers, Inc. (Fort Worth, TX) adds to its growing arsenal of reliability solutions with its new Clear Grease Guns, a simple, cost-effective solution for avoiding costly grease cross-contamination errors. Clear Grease Guns ensure 100 percent visual grease identification.
Kanban Made EasyNovember 10, 2009 10:59 am
Magnatag (Macedon, NY) offers the CardView Kanban boards to coordinate inventories and lean workflows. The kits come in five formats: Next-Job, Build-Board, Job-Load, To-Do, and On-Hand. Each comes ready to use in six size capacities, including kanban cards in 17 colors, card printing templates, color pocket tapes, and press-on FlashSpot so customers can tailor the board to their needs.
When Seven Monitors Isn't EnoughNovember 10, 2009 10:58 am IMPO
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Analog-Compatible Draw WireNovember 10, 2009 10:57 am IMPO
Kübler by TURCK (Minneapolis, MN) has expanded its draw wire series, designed to work with sensors and encoders with analog outputs, with versions that measure distances ranging from 0.2 to 40 meters. Compatible outputs include 0 to 10 volt, 4 to 20mA, and potentiometers, as well as incremental (push-pull and RS422), absolute (SSI and BISS), and fieldbus interfaces.
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The pop-up transfer conveyors from TKF (Cincinnati, OH) are light-duty units designed to handle loads up to 250 pounds with motorized roller-driven strands, eliminating noisy chain drives. The conveyors also do not use vertical guides or cam ramps for positioning, which simplifies maintenance.
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Sullair Corporation (Michigan City, IN) announces the redesign of their 200 HP compressors offered with a choice of constant speed drive models (the LS-200S) or constant speed drive with variable capacity control (the VCC-200S and VCC-250S). The VCC models use Sullair's spiral valve technology, which allows the compressor to match pressure and capacity with system demand, lowering energy usage.
Be A SquareNovember 9, 2009 10:25 am IMPO
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Network MeshingNovember 6, 2009 10:43 am
Detcon (The Woodlands, TX) has released the Model RXT-300 wireless mesh-network transceiver, designed to transmit signal data in a wide range of industrial applications. The transceiver operates at 2.4GHz, and processing power is shared, allowing each transceiver to act as both a router and repeater.
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The OCAL-BLUE Form 8 PVC-coated cast-iron conduit body from Thomas & Betts (Memphis, TN) now carries the UL Type 4X and NEMA Type 4X ratings on sizes up to two inches. These ratings assure conduit protection and corrosion-resistant performance in wash-down areas and outdoor environments.
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Breaking Up Is EasyNovember 6, 2009 10:41 am
Eriez (Erie, PA) is introducing the PolyMag Process, which provides multi-material plastic processors with material savings by creating a material that incorporates separation characteristics into the design. By introducing less than one percent of the PolyMag Additive, the leftover scrap resin from co-injection, two-shot injection, or overmolding processes can be separated with high-intensity magnets.
SmartBobbing For ApplesNovember 5, 2009 4:07 am
BinMaster (Lincoln, NE) announces the SmartBob-SS sensor, which is designed to measure solids submersed under water. The sensor is a solution for brine interface applications, such as measuring the level of settled salt under water. The SmartBob-SS drops a weighted bob through the liquid, and when the bob comes in contact with solid settled material, it retracts and sends a measurement to a PC loaded with eBob software.
Counting, Made EasyNovember 5, 2009 4:07 am
Mettler Toledo (Columbus, OH) introduces the BBA449 counting scale that allows molding machine operators to more effectively supervise their machines. The colorWeight display alerts operators if boxes are full with a visible display—useful for operators responsible for multiple machines.
SuperStar Of FiltersNovember 5, 2009 4:06 am IMPO
The SuperStar .01 Micro Filters from LA-MAN Corporation (Port Orange, FL) are designed to be installed at the point of use to remove moisture and contaminants from air lines to improve the life cycle of tools and equipment. The four-stage design operates most efficienty within 25 feet of the point of use, and has a flow range of 50, 75, or 100 SCFM with pressure ratings of 250 psi.
Linear Bearings That Won't BreakNovember 5, 2009 4:05 am IMPO
Thomson (Wood Dale, IL) introduces the RW64-V RoundWay Linear Roller Bearing, a 4" version with a dynamic load capacity of 70,000 lbf (310,800 N), more than 20 times the load capacity of a conventional linear ball bearing. The RoundWay can carry that load even at operating temperatures up to 500°F and speeds up to 100 ft/s (68mph).


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InSinkErator QCB-AM Anti-Microbial Quiet Collar Sink Baffle
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The Insinkerator Anti-Microbial Quiet Collar Sink Baffle - Black (QCB-AM) is a replacement sink baffle for the Insinkerator Evolution Series Disposers, helping to reduce sound easily. The Quite Collar Sink Baffle is easily removed for cleaning and is coated in an antimicrobial solution, which helps inhibit growth of odor causing bacteria.
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The Fairy Castle
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EWTN broadcast of discussion with UN Expert. Raymond Arroyo boils down the "international right to be able to abort your fetus" as a false idea based on non binding data. The guest calls the international right to abort your child an idea that is built like a "Fairy Castle". All US citizens know and believe in the Declaration of Independence which clearly states the contrary.
United Nations Abortion LIfe Fairy Castle Hillary Clinton Obama Administration Binding
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Five children pulled from frigid pond after Minnesota car crash
A car carrying five young children slid into a near-freezing pond in Minnesota for 45 minutes on Thursday. One child died and the others were unconscious and unresponsive when pulled from the vehicle.
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ST. LOUIS PARK, MINN.—Rescuers worked frantically to free five children trapped in a submerged car after it veered off a highway ramp in suburban Minneapolis and into a frigid pond, smashing windows to get inside even as a tow truck winched the car out. One of the children later died, the Minnesota State Patrol said.
The car was under water for up to 45 minutes after Thursday's crash. St. Louis Park city spokesman Jamie Zwilling said the children were unconscious and unresponsive when pulled from the vehicle.
Conditions of the surviving children were not available Thursday night, and officials didn't provide details on the children's injuries or whether the car had filled up with water before rescuers got to the youngsters.
The driver of the car — mother and stepmother to the children — made it out on her own. One witness described seeing her in the pond, screaming for help.
"The car was under water, and she must have been standing on top," Jeff Robertson, who lives in a nearby apartment building, told the St. Paul Pioneer Press. "That pond is 8 or 9 feet deep, and the water was at her knees."
The crash happened in St. Louis Park, a western Minneapolis suburb. State Patrol Lt. Eric Roeske said the car angled left off the ramp from Highway 7 to Highway 100 and plunged down a slope into the pond about 45 metres from the roadway. He said there was no guardrail separating the pond from the ramp.
The driver was identified as Marion Guerrido, 23, of Brooklyn Center. The Minnesota State Patrol identified the children as Aliyana E. Rennie, 1; Zenavia C. Rennie, 5; Zarihana M. Rennie, 6; Amani N. Coleman-Guerrido, 5; and Alarious M. Coleman-Guerrido, 7; all of Brooklyn Center. On its website, the patrol said Zenavia of Brooklyn Center had died.
Roeske said the first victim was pulled from the water about 25 minutes after the crash was reported about 6:10 a.m. Rescuers pulled the children out slowly, one by one, and the last wasn't removed until her or she had been in the water 45 minutes, he said.
Passers-by attempted to rescue the children before police arrived, but the 1998 Pontiac Grand Am was submerged in about three metres of cold water. Roeske said the "incredibly cold, nearly freezing-temperature water" would have made it difficult for anyone to reach the children.
Roeske said investigators were working to determine whether speed was a factor in the crash. The road was wet from light mist, but not icy, he said. He said there was no indication that Guerrido intentionally drove into the water. No alcohol was found in her system.
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The Centers for Medicare & Medicaid Services (CMS) issued a final national coverage determination that provides for Medicare coverage of Screening for Lung Cancer with Low Dose Computed Tomography (LDCT).
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Governor Names Interim Director of Health and Human Services
Governor Brian Sandoval has announced that Richard Whitley has been appointed Interim Director of the Department of Health and Human Services (DHHS). Whitley currently serves within DHHS as the Administrator of the Division of Public and Behavioral Health.
HHS Director Romaine Gilliland will return to retirement after an accomplished career in public service having worked in the Department of Employment, Training and Rehabilitation and Administrator of the Division of Welfare and Supportive Services.
"Richard has served as a key member of Nevada's Health and Human Services team, has demonstrated extensive knowledge and focused leadership, and will bring these skills into his new position. The Department of Health and Human Services is our largest state agency and houses many of the essential programs necessary to help promote a healthy citizenry," said Governor Sandoval.
Sandoval. "I would also like to thank Romaine Gilliland for his commitment to public service. Romaine selflessly left retirement and temporarily took the helm of DHHS last June during a time of transition, cultivating the department's current leadership team," Sandoval said.
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This 30-second glimpse gives a lot of clues in what's to come with the April 10 release of Netflix's first superhero foray. Check out Murdock's reflection for a hint of the outfit that will strike fear into the hearts of Hell's Kitchen criminals.
The crime boss, Wilson Fisk has been a classic street level nemesis for Daredevil and Spider-Man since 1967. Aptly played by the late Michael Clarke Duncan in the 2003, Ben Aflleck Daredevil movie, we can't wait to see brawling Kingpin menacingly played by Vincent D'Onofrio.


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Another wedding question
Started by Nofliesonme , Feb 25 2013 01:34 PM
25 replies to this topic
Posted 25 February 2013 - 01:34 PM
So as previously stated we are running off and having a small wedding etc, many friends and family aren't coming and many will not be able to make it to the gathering we have a few weeks later..
I don't want gifts etc but know many people will still want to wish us well etc.
If I include a blank card and a message that reads.
Because you couldn't be with us on our special day,
We thought you might like to wish us well, anyway.
Enclosed is a blank card just for you, to write
your well wishes for us two.
Write what you wish, write what you may,
to be stuck in a book forever and a day.
If this is something you'd like to do
Please post card back to the following address:
Is that too forward. I figure it implies we only want the card back and it would be a lovely keepsake for us if they did return it.
Posted 25 February 2013 - 01:37 PM
I've never heard of this before but if your friends & family have RSVP's that they can't attend etc then I don't see the harm...although most caring individuals I'd think may send a card regardless.
Posted 25 February 2013 - 01:43 PM
Id just let them pick their own card, I love reading all the cards and finding one that suits the couple. Much more personal I think.
Posted 25 February 2013 - 01:44 PM
You'll probably receive cards from your friends and family anyway. If somebody asks you what you want for your wedding you could say you'd love to receive a nice card to make a booklet, or you could get a close friend to organise it for you. But it seems unnecessary to send people notes essentially asking them to "please write us a card."
Posted 25 February 2013 - 01:46 PM
I would prefer a message along the lines if 'we're sorry you couldn't make it to our special day. If you would like to, please enclose a message and post to XXX'
Posted 25 February 2013 - 01:47 PM
I'm a little confused by the timeline....
Is it - You invite someone, they RSVP and decline, you then send them a card asking for well wishes?
If this is the case then I think it is a little odd.
Normally when we are unable to attend a wedding, I send a lovely card wishing them well with a note declining the invitation. Then, if we are close to the couple, a gift follows closer to the time.
I don't like the idea of being pressured or made to feel obliged to send a note with well wishes.
Good luck.
Posted 25 February 2013 - 01:48 PM
I'd avoid the phrase 'wish us well' as it's one that's become synonymous with the option of giving money instead of a gift and I don't think you want to imply that.
Posted 25 February 2013 - 01:53 PM
I agree that it sounds like you're still asking for money.
Posted 25 February 2013 - 02:00 PM
I don't like the idea. If I received that it would sound to me like you want me to send the card back with money in it. (which I would normally do if I wasn't attending a wedding anyway with a card). So I kind of see it as you are being a bit pushy??? If someone wants to send you a card and a message, they will. Otherwise its kind of like you are pushing the point.
Posted 25 February 2013 - 02:02 PM
Never heard of this before. It's a nice thought, from your perspective. However, I suspect people who want to send you a card will do so, off their own bat, without any prompting. Otherwise, you are putting your friends under a bit of pressure to perform as expected, IMO.
If you do go ahead with this, include a self-addressed stamped envelope. You might as well go the whole way and make sure you get the note returned.
QUOTE (niggles @ 25/02/2013, 01:48 PM) <{POST_SNAPBACK}>
I'd avoid the phrase 'wish us well' as it's one that's become synonymous with the option of giving money instead of a gift and I don't think you want to imply that.
Posted 25 February 2013 - 02:09 PM
Personally I wouldn't do it that way.
As you aren't having many people at your wedding itself, I'm guessing you are sending out an announcement rather than an invitation. In which case I think you only need to announce the fact that you are married and then leave it up to people to decide for themselves just how they want to "wish you well".
It seems a bit contrived to ask people to send you something - if they aren't at either celebration and don't choose to send a card or anything else, they they probably aren't close enough to matter if they are included in your memory book.
Posted 25 February 2013 - 02:12 PM
All good then, yes I have sent out Cards inviting people to a gathering after our wedding..... A few weeks after. Today I received 12 phone calls from people who can not attend as they all live too far away....they said they will return their RSVP in the mail but because they all know my phone number though they'd ring... ( I would assume that's why they rang ) lol. Anyways I was sitting here and just thought oh maybe I could make a book of cards etc.... I'm sure they still want to give us their best wishes for the future....
But obviously it seems as though that idea is on the out. And definitely don't want to imply that we want money... I didnt think it implied that but obviously by thE majority rule it does
Thanks anyway
ETA I took a previous Ebers advice and sent out announcements advising we are getting married on a particular date at a small private gathering...I also included the invite to the get together on ..... Of April.
Edited by thunda, 25 February 2013 - 02:15 PM.
Posted 25 February 2013 - 02:35 PM
If people want to send you well wishes or a card they will.
I think its rude and also seems like a Wishing Well money grab for those that cant make it.
Posted 25 February 2013 - 02:40 PM
Odd. I wouldn't like it and would assume it was wanting a cheque put with the card.
I am a grown mature adult and like to choose my own cards and decide whether I want to write a message. I don't need someone telling me to do it.
Sorry I know you mean well but I really really dont like it and would probably throw it in the bin in a huff.
Posted 25 February 2013 - 02:58 PM
It sounds like a cute idea in theory, but in reality, it's not. Those who want to wish you well will do so.
ETA: maybe the OP got the idea from the old acceptance cards ... I have memories of wedding invitations with their own acceptance cards that you sent back and these were often kept by brides. Bit late for that since you've already sent invites though.
Edited by CrazySingleMum, 25 February 2013 - 03:00 PM.
Posted 25 February 2013 - 03:26 PM
Edited by bye, 29 March 2013 - 02:18 PM.
Posted 25 February 2013 - 07:03 PM
Thanks, I don't have parents to ask so hence I turn to eB. Lol I'm sure they can steer me in a direction that's acceptable. Lol
So will just pop their cards in a box instead...why does everyone assume people want gifts or money just because they got married...some of us genuinely have no interest in that
Edited by thunda, 25 February 2013 - 07:05 PM.
Posted 25 February 2013 - 07:10 PM
QUOTE (niggles @ 25/02/2013, 02:48 PM) <{POST_SNAPBACK}>
I'd avoid the phrase 'wish us well' as it's one that's become synonymous with the option of giving money instead of a gift and I don't think you want to imply that.
#19 Guest_GreyMatter_*
Posted 25 February 2013 - 07:19 PM
Sounds nice in theory and I can see the idea, but if I got something like that I'd think that the couple were looking for money.
QUOTE (thunda @ 25/02/2013, 08:03 PM) <{POST_SNAPBACK}>
Thanks, I don't have parents to ask so hence I turn to eB. Lol I'm sure they can steer me in a direction that's acceptable. Lol
So will just pop their cards in a box instead...why does everyone assume people want gifts or money just because they got married...some of us genuinely have no interest in that
I don't assume that people want gifts or money and depending on who the couple was I'd probably send something anyway, but it just seems a little "proactive" (for want of a better word).
Posted 25 February 2013 - 07:19 PM
I would find it very odd. I definitely wouldn't recommend it. Keep the ones you receive, but don't ask people to send them!
Posted 25 February 2013 - 07:28 PM
QUOTE (thunda @ 25/02/2013, 05:03 PM) <{POST_SNAPBACK}>
So will just pop their cards in a box instead...why does everyone assume people want gifts or money just because they got married...some of us genuinely have no interest in that
I kept all my wedding cards in a box and it is lovely. I read through them only recently when we moved house and it brought a smile to my face. I also have boxes for the cards from when both my bubs were born.
Posted 25 February 2013 - 07:29 PM
I too have kept the cards from when all kids were born
Posted 25 February 2013 - 07:35 PM
OP I get what you are driving at. You want people to know you value them, and give them the chance to participate, even though they can't be at the wedding.
I'd get prints of your favourite photo(s) from the wedding (an informal one if you havent got the official "photographer" ones back) and send them to everyone who couldn't be there. I guarantee you'll get cards/emails/FB comments and you can print them for your album.
Posted 25 February 2013 - 08:52 PM
QUOTE (meggs1 @ 25/02/2013, 07:35 PM) <{POST_SNAPBACK}>
OP I get what you are driving at. You want people to know you value them, and give them the chance to participate, even though they can't be at the wedding.
I'd get prints of your favourite photo(s) from the wedding (an informal one if you havent got the official "photographer" ones back) and send them to everyone who couldn't be there. I guarantee you'll get cards/emails/FB comments and you can print them for your album.
I like this suggestion.
Posted 25 February 2013 - 09:22 PM
I actually like the idea in theory. When we married, all of dh's family was overseas. We asked for them to write a message to be shared at the wedding & these were read out by the bridesmaids like the telegrams in the old days. You could read out the best ones & make a display board of the rest with the guest book. You could ask people with Something along the lines of, we would like you to still be part of our special day... Perhaps get your mother or bridesmaids to write to those not coming & ask if they wanted to send a message for the day? That may take away the possible cash in a card feeling.
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Critical TopicsAutomation Containers & Totes Conveyors & Sorters Energy & Sustainability Inventory & Picking Lift Trucks & Accessories Loading Dock Equipment Materials Handling & Warehouse Ergonomics Mobile & Wireless MODEX 2014 Packaging ProMat 2015 Shipping Pallets Storage Systems All critical topics or View all topics
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During this Webcast you'll learn how the latest generation of robotics systems, which incorporate vision, mobility, autonomous navigation, complex manipulation and motion control, can be used in a wide variety of appliations such as picking, placing, order fulfillment, palletizing, depalletizing, loading, unloading and many other areas.View more webcasts
Comprehensive news on the most advanced systems for automated mobile data collection & paperless picking of inventory through RFID and wireless technologies.
Inventory & Picking ResourcesMitigate the negative effects of slow-moving inventory
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The battle to harness the power of the seven Dragon Balls explodes in vivid detail like never before. The Dragon Box features over 40 uncut episodes, remastered and restored frame by frame, rendering the legendary action in pristine clarity. Each episode is presented in Japanese and English with the complete opening and closing credits and includes the original episode previews.
The last survivors of a cruel, warrior race, these ruthless villains have carved a path of destruction across the galaxy, an now they have set their sights on Earth! They will stop at nothing until they have the wish-granting powers of the seven magic Dragon Balls for their very own.
With the fate of his family, friends, and the entire human race hanging in the balance, Goku, the Earths greatest hero, must rise to meet the approaching threat. As he prepares for the fight of his life, Goku embarks on n epic journey that will take him to other worlds, pit him against new and old enemies alike, and force him to confront the dark secrets of his own past. At the end of this path, the most powerful opponent he has ever faced awaits: the evil Saiyan Prince Vegeta!
Contains episodes 1-42.
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Spoken Languages: English, Japanese, English subtitles.
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The Carpenters Arms has recently re-opened as a family-friendly gastropub, and is located only ten minutes' walk from the centre of Cambridge. Accommodation is available, and guests can enjoy award-wi...More about The Carpenters Arms
This lovely village inn provides comfortable, well-equipped bedrooms. A range of quality meals is served in the many dining areas, complemented by a good variety of real ales and wines. Service is fr...More about The Rose & Crown
Located beside the New Bedford River with stunning country views, this 17th-century inn has a wealth of original features complemented by period furniture, and the spacious bedrooms are tastefully app...More about The Anchor Inn
The Queen Victoria is located in the coastal village of Snettisham, close to the beach, not far from Sandringham. Comfortable accommodation is provided to the rear of the property, and guests can enjo...More about Queen Victoria
Meadow View is a stylish property situated just a short walk from the town centre and Burghley House. The tastefully appointed bedrooms are contemporary in style with lovely co-ordinated soft furnishi...More about Meadow View
This country inn is set in the pretty north Norfolk village of Burnham Market, within easy reach of King's Lynn, Norwich, Hunstanton and Cromer. There are four en suite double rooms available, all wit...More about The Nelson Country Inn
A very warm welcome is assured at this delightful farmhouse located at the heart of an arable working farm. Kings Barn really is a peaceful rural retreat. There are two en suite bedrooms which have th...More about Kings Barn Farmhouse Bed & Breakfast
This beautiful building, which dates back in part to medieval times, has been transformed to enhance its many quirky architectural features. The bedrooms and suites, some with private terraces, have ...More about Hotel du Vin Cambridge
A personal welcome is guaranteed at Boston Lodge. Located in a quiet village on the outskirts of Boston within easy reach of Sleaford and Lincoln, it is an ideal base for both the tourist and business...More about Boston Lodge
Clarice House is a large country property set amid pretty landscaped grounds a short drive from the historic town centre. The spacious, well-equipped bedrooms have co-ordinated fabrics and many though...More about Clarice House


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Dec 31 - Homily: Mary Magnifies the Word
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The Word - Jesus Christ - enlightens all men. The mystery of Mary further magnifies and clarifies the Divine Logos for us. Ave Maria! Mass: 7th Day in Octave of Christmas - Wkdy - Form:ĀOF Readings:Ā 1st: 1jo 2:18-21 Resp: psa 96:1-2, 11-12, 13 Gsp: joh 1:1-18 To Download Audio go to http://airmaria.com?p=40412
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text: Stayed here for a week on a business trip - the hotel is fantastic. The rooms are very spacious and quiet for new york, despite being in a great location. The communal areas are comfortable, although the happy hour is admittedly a shambles as there isn't enough seating space so people were sitting down on floor - sort this out... More


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This was from the '06 L.A.P.D. 5-0 Car Show
KID DEUCE, xxmachonexx, trrll.poole, and 5 other people added this photo to their favorites.
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The Spanish gypsy Carmen lives only for sensuality and manages to seduce the naïve sergeant Don José with her wiles. His love for Carmen leads him to attack his superior officer, desert his military duties and abandon his childhood sweetheart. He then joins Carmen and her band of smugglers. Unf... read more
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G-MAX Reverse Bungy & GX5 Extreme Swing
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Farmhouse fixup
Before and after; a farmhouse gets a facelift
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"This is the house after we first moved it in and painted it," says Cheryl. "I used a sample of siding to color match the blue paint. Ten years later, when we started remodeling, that turned out to be a good decision."
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Arrest-Related Deaths: Excited Delirium Syndrome (POSA)
Arrest related death and Excited Delirium Syndrome are becoming a hot topic in law enforcement. Often unknown, Off. Staton presents and introduction to the subjects, including the symptoms to look for as well as suggestions dealing with arrest related issues. NOTE: The accompanying PowerPoint file may be downloaded at www.posai.org/access-training-programs
Arrest-Related Deaths: Excited Delirium Syndrome (POSA)
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Carol of the Drum - for Jazz Ensemble
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Carol of the Drum - for Jazz Ensemble composed by Traditional Czech Folk Song. Arranged by Kate Agioritis. For Piano,Saxophone,Trumpet,Trombone,Drums,Guitar,Jazz Ensemble. Jazz,Rock,Christmas. Intermediate. Score,Set of Parts. Musika Publishing Australia #00090. Published by Musika Publishing Australia (S0.10475).
This traditional Czech folk tune is more commonly known today as 'The Little Drummer Boy', as adapted in English by Katherine Kennicott Davis in 1941. This funk version of the traditional tune is a fun addition to your festive repertoire. Download includes a score and a full set of parts. View the full catalogue of Musika works on our website: www.musika-publishing.com LIKE Musika Publishing on Facebook! .
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