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Here is a video I just discovered of the 45,000 square foot Fleur de Lys Estate when it was shown on HGTV. The owners commissioned architect Richard Robertson III to design them their very own "French Palace". The home is filled with dozens of rare Louis XIV and Louis XV antiques. If you don't already know, the home is owned by Suzanne Saperstein and is on the market for a whopping $125 Million. It is located in the Holmby Hills section of Los Angeles, CA. It was once the world's most expensive home back in 2008.
The Fleur de Lys Estate on HGTV
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22 Comments
I have hated this house from the time I first saw it when it came on the market a few years ago. Pretentious with a capital P. The scale and the engineering to build it are impressive, but for $125,000,000 I would like a house that doesn't need to have its interior gutted and rebuilt in order to make it comfortable and tasteful.
God, is there a place to actually sit down and relax? To watch a television, have a drink with friends, play with your kids? This is basically nicer than a museum, which makes it worthless as a house. The U.S. was formed partly to get away from the rule of kings and queens that wasted money on such over the top decor. What a sad comment on what we (some of us) have once again become.
Now drop the price to 50 million and sell the thing, Suzanne.
I've always loved the exterior and property but hated the interior. I have great appreciation for the detail and effort that went into the interior but as KEV said, this place is more museum than house. It's almost like they didn't even want to live there they just wanted to be able to say they owned this place.
I think this home (and yes I said "Home") is Gorgeous! A true work of art!The attention to detail is impeccable. It's cozy, in a glamorous but elegant way…reminds me very much of a home Liberace would live in. I personally would be very comfortable living here and I've always said, if I could live in LA it would be in The Holmby Hills section of Bel Air. But then again, not everyone has over the top extravagant taste, which is something I've always had, and I don't see anything wrong with wanting the finest things in life. It always amazes me how the more flamboyant and glamorous something is, it evokes and underlying anger, jealousy, and dislike for it. My motto is, if you've got it, flaunt it. Especially, if you've worked hard for it.
I suggest you look up the definition of the word "cozy." And the home was built "for" his wife, who loaded it with all the gaudy 18th century furniture and 24k gold. To suggest she has "worked hard" for this property is grossly misinformed, unless you count laying on her back as work. Google a recent picture of her and you'll see a Joan Rivers starter kit as far as plastic surgery gone awry. I don't dislike it because it's glamorous, because it isn't. It is a vacant and heartless display of ego and narcissism.
KEV; not cool to judge people like you're doing here! I'm no fan of hers, but she's worked her butt of together with her ex-husband to build their business. She' more of a workaholic than anything.
And why are you guys so judgemental of the fact that someone chooses to spend THEIR money the way they want to? Isn't that what America is all about? They've made it, let them fulfill their dreams. I agree that it's not vert tasteful, but people have different tastes – and thank God for that!
Don't perticularry like the house as a house. But love the attention to detail and very interesting to learn more about the house. Thanks for the vid, Kevin! Great stuff!
I agree with you Laquayva! I'd only want the place if the furniture was part of the deal! It does seem sad to me that the kitchen is completely a commercial one. I guess if you have that kind of money, you always have a chef on the staff. What happens when the chef is on his days off? Probably you've employed a Major Domo who will lightly cook. I just cannot imagine living in a residence (& I love this one) where you can't go into a family kitchen & cook!
The older I get, the more I would be satisfied at living in a 5 million dollar home! When I was 18, I would have said 125 million dollar home. I now know what things cost from personal experience. I'd rather save a few million to help keep me in that 5 million dollar home. I still would hire 1 good person to drive me (when I feel like it), cook lightly and someone else to come in and clean. So it would be a little hard to imagine needing a staff of 10 – 15 plus all the gardners, etc. Do I think it's overpriced? For todays market, absolutely! She's going to have a day where she wished she had taken that 85 million dollar offer!
I hate this house, never cared for it, and the video only emphasizes that.
I suspect everyone else who has looked at it feels the same way as it has not sold after all this time.
I can't imagine raising a family in that house. Twenty years ago my family consisted of 2 teen aged boys, both jocks, three Mastiff dogs, and two cats. The house is ment to impress people, not really to house them.
I LOVE this place, although I would have made sure to make some of the rooms "liveable" as opposed to just for show, and I also would have made the home smaller overall most likely (I think this place is like 45,000 square-feet or more), which is just too big for one or two people (too much money spent on maintenance).
But otherwise, this place I like very much. It does seem a little cold in certain areas, but such a place can very much be made very cozy with the correct interior design and furniture.
Same with that big Texas French palace that was built, only for the couple trying to sell it now, I love that too, but would have made it a bit smaller.
The big Texas place is Champ d'Or. I also loved Robert Eustace's 50,000 square-foot mega-mansion.
I love this video I Love knowing that they out bidding the louvre for things.
I do not understand people who say this home is unlivable, I can see myself using all these rooms, as Im sure the Sapersteins and like-minded people do.
Something doesn't need to be common in order to use it.
I do not believe this home represents a tacky flashy mentality (Like the Tar estate) its simply a family that likes fine french antiques.
I could easily sit and relax and watch tv with my friends in the finest furniture and decor, EASILY!
I do believe this house is worth $125 mil, comparatively. It hasnt sold but I think thats a representation of the market not the home. Suzanne as said before she will wait as long as it takes. It seems the public that cant afford it are more anxious than she is!
I like that there is a lot of positive feed back to this video, it seems the Sapersteins have been given a hard time for …owning a nice house?
Love it
I don't know why, but that entry foyer looks cheap. Perhaps its the gilt and color scheme?
I agree with the majority of the other comments here. I wouldn't want to live in a home that discourages walking, sitting or touching.
Mariah Carey owns the house. She paid $100 million, cash for it with husband, Nick Canon
Does Mariah Carey really own it, or is that a misconception? I mean that would be like half her entire net worth just to purchase the thing.
Also I agree with Daniel, the entry foyer does look cheap, I was thinking maybe that is just the design?
Also didn't the home cost around $40 million or $50 million to construct? I don't think it is worth any $125 million.
"Only" 40-50 million? I would've expected something like 70-80 million at least. Do you have any sources to confirm? Not that I don't trust you, I just want to get a feel for what type of costs is affiliated with building a house like this with so much detail and expensive materials.
And does anyone have any idea of how big the plot is? That has to be worth quite a bundle in the midst of Bel Air in itself.
It seems like alot of these big homes are just short time obsessions for the builders and as soon as the decorating and the construction are done they loose the high and then sell it, maybe because it reminds them how empty and lonely they feel inside.
I still dont get the phenomon of building these mega homes and then immediately off loading them if they can, its like how can someone whose amassed that sort of wealth make such a poor decision
i guess this is an example which illustrates ostentatious.
prince aziz
il love this it's royal i think that you can rase a family in it with royal manners and how to act like prince or a princess tv is not for grown up people and i think that suzanne worked hard for it and someday if i bought this house i will add more modification with my touch it will be better then the versailles palace
Sony Exec Film Tv
I went to an Entertainment Oscar Party there, when Film Producer Eve St.Charles owned the home, this vid doesn't do it justice. I think she sold it because, she didn't like the neighbors or the noise. But, believe me, its a beautiful home. The vid doesn't show half the house, too bad. Pretty much, all of Hollywood is too noisy now, my wife & I, are a few blocks over, too many rockstars!! maybe thats why! If this house was somewhere else, instead of the center of Hollywood, it would of been better. Bad location for peace & quiet, for sure!!


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On Wednesday, a Midland man was sentenced to ten years in prison and assessed a $10,000 fine.
U.S. Customs and Border Patrol say one 44-year-old man tried to cross the border with drugs hidden "internally".
Reading in the upper 70's to near 80 degrees tomorrow.
The Junior League of Midland is hosting Shotguns and Stilletos, a multi-day celebration of shopping, shooting, and socializing.
Amber Mendoz arrested and charged with sexually assaulting a sixteen year old.
The Midland Police Department is asking for the public's help in identifying a suspect wanted for putting a card reading device at an ATM.
A man was arrested Tuesday after trying to rob a woman at Wal-Mart, and then fleeing the scene.
A father and daughter from Pecos are going to federal prison after distributing over 3000 grams of methamphetamine.
Dozens of cars in Midland and Odessa were damaged after a rash of overnight vandalism.
The former head boys basketball coach for Permian High School will be reassigned a teacher/coach at Nimitz Junior High.
The Midland Opera Theater brings the Texas Tech University Music Theater and Orchestra students to perform Donizetti's comic opera Don Pasquale.
A proposed bill could ban tobacco-use on Oklahoma public school campuses 24/7.
Tuesday morning, police were called to an Odessa neighborhood for reports of shots being fired.
Odessa Police have responded to 28 incidents of criminal mischief involving windows that have been shot out with what appears to be a BB gun.
March is Brain Injury Awareness Month, a time to bring awareness to the needs of brain injury survivors and stress the importance of preventing brain injury.
Traffic signals at four intersections along Missouri Avenue in downtown Midland will be permanently converted to all-way stop signs beginning Thursday, March 19.
A woman was arrested on several charges after biting an officer on the arm.
A man has been arrested after assaulting his teenage girlfriend back on March 8.
Over a three day period, Border Patrol agents from three stations in the Big Bend Sector seized a total of 2,011 pounds of marijuana worth $1.6 million in five separate cases.
U.S. Customs and Border Protection Office of Air and Marine Air Interdiction Agents and a Border Patrol Emergency Medical Technician saved the life of a Mexican man who fell from a cliff in a remote area south of Sierra Blanca.
One man is dead after a Monday morning car crash engulfed his car in flames.
After months scrutiny in 2014, Veterans Hospitals across the country are finally starting to see some improvement.
A handful of ECISD AVID students are trying to win their very own laptops.
MIdland police say an area is blocked off and tactical teams are on scene as they are trying to place a suspect in custody.
More than 40 dogs were being transported from Big Spring to Kansas City to avoid euthanization.
Catfish and Rainbow Trout dead in C J Kelly Park.
Odessa police say they found an infant with "serious" head injuries, as well as injuries all over her body Monday morning.
A Press release details the facts according to the Howard County Sheriff's Department
Over the weekend, Midland's Horse Shoe Arena hosted The Celtic Heritage Society of the Permian Basin's annual Scottish Irish Fair.
Even though the Jaycees had a slower than normal hunting season, it surely doesn't look like it. Over 3,000 pounds of rattlesnake were at the Roundup.
A group of local architects volunteered their time this weekend to build homes for people in need.
Hundreds came out this weekend to participate in the Color Vibe 5k and support the Boys & Girls Club of the Permian Basin.
Each year a group of around 40 west Texas students choose to giving up spring break fun in the sun for fine arts fun in the Permian Basin.
Soles truly touching the souls of children in need.
High temperatures in the upper 60's Saturday and Sunday.
A new bill introduced to the House of Representatives causing controversy.
Big Spring ISD has been placed under accredited probation.
The most colorful 5K on the planet returns to Midland.
Drivers on FM 1450 in northern Pecos County need to be on the lookout for a lane closure and crews working over the next several weeks.
UPDATE: OPD: Peralta De Valdez was located this evening at approximately 1900 hours and is no longer missing.
A man has been arrested after killing a dog with a pair of scissors last month.
Texas state lawmakers introduced a bill Friday that would allow certain patients access to medical marijuana.
A woman attempted to stop a robbery early Friday morning by jumping on the suspect's back.
One man is behind bars after a Thursday night stabbing.
Highs near 70 degrees under partly sunny skies.
An Odessa police officer was stabbed Thursday morning after trying to chase down a suspect.
Safety experts and consultants say that the majority of explosions and accidents at work sites are commonly caused by employees not following the safety rules.
He's a real-life Forrest Gump, running from state-to-state for a good cause.
A man was arrested Saturday after assaulting his wife and threatening her with a machete.
A man was arrested Monday morning after assaulting two police officers.

subset: commoncrawl


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You've gotten a lot of good advice already. Just one more thing. You don't say whether the plan is to keep the home or sell it. If you will want to sell it soon, it may be easier to do a "life estate" deed while mom is living. This would avoid the capital gains tax, and also avoid the (usually year-long) period after mom passes away during which the house would be hard to sell because of probate and creditor rules.
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1 person marked this answer as helpful
If the trust is administered in California it will be governed by California law and you need to consult a Cal. attorney (which I am not) to represent you. When I advise Trustees, if there is any hint of a dispute over asset division, we draft a letter that is to be signed by all beneficiaries BEFORE any assets are distributed. The letter agrees to the distribution as a full and final settlement. If any beneficiaries are unwilling to sign, we advise the Trustee to seek a court order directing...
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Because their dad was a NJ resident, the children should consult with a NJ lawyer promptly because the estate matters need to be handled there. Under the law of most states, when there is no will and no surviving spouse, adult children will have priority to be executor. However, sometimes a delay (meaning not applying promptly to be executor) will let others step in.
2 lawyers agreed with this answer
Under Maryland guardianship law, one is a minor until age 18, but a youth over 14 years old can tell the judge who the youth wants to live with and the judge will respect that choice unless there is a good reason not to do so. This applies to guardianship of the person only (who the youth lives with); it does not apply to guardianship of the property (who manages the money). See Maryland Estates and Trusts Code, section 13-702.
1 lawyer agreed with this answer


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Emmys: 'Orange Is the New Black's' Uzo Aduba Makes a Plea to Voters (Guest Column)
This story first appeared in the June 13 issue of The Hollywood Reporter magazine.
As the excitement of TV's biggest night draws closer, it's crucial that we examine the cavernous absence of diversity and full inclusion in the TV awards conversation. The industry long has avoided the subject, perhaps even ignored it! The last series with a non-white cast to win the comedy Emmy was The Cosby Show in 1985. The last woman of color to take the comedy actress prize was Isabel Sanford (The Jeffersons) in 1981. Today, with the groundbreaking impact of Orange Is the New Black, it's time for Emmy to not only redefine what a winning comedy is but also what "Emmy worthy" looks like.
PHOTOS: Taylor Schilling, Laura Prepon Walk Free at the 'Orange Is the New Black' Season 2 Premiere
I did a play called Eclipsed that told the story of five African women in war-torn Liberia. The director, writer and members of the main production team were diverse women. I wouldn't have this experience again until five years later when I was cast in Orange, the Netflix series that uses the setting of a women's prison to unite dozens of distinct, robust female characters, a first for television.
Growing up, I had to look at separate pockets of TV to find versions of myself, from characters like Khadijah (Queen Latifah) on Living Single to Carrie (Sarah Jessica Parker) on Sex and the City. With Orange, the mix of women -- black and Latina, white and Asian, transgender, gay, straight -- reinforces a new reality: Their stories matter, too.
STORY: 'Orange Is the New Black' Cast Talk Season 2 Backstories, Relationships and Racial Clashes
Series like Orange and Scandal happen because creators such as Jenji Kohan and Shonda Rhimes are brave enough to try to change the landscape with bold words and casting choices. Working on our show often feels like that moment when Dorothy's house lands in Oz, she opens the door and suddenly a mix of colors floods the screen. She didn't realize what she'd been missing.
A nomination for Scandal's Kerry Washington last year was one step in Emmy's journey toward equality. Hopefully, with Orange, the TV Academy also will see fit to open its door toward a more colorful future.
Uzo Aduba plays Suzanne "Crazy Eyes" Warren on Netflix's Orange Is the New Black.
Never miss a story. Stay up-to-date with THR's Daily Headlines.
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Hide Property Details
Description from the owner
- 4 bedrooms
- 2 bathrooms
- Sleeps 12
- Cottage
Bedrooms: 4
Bathrooms: 2
Sleeps: 12
Type: CottageLake Ontario/Niagara Falls-Year Round Cottage
Description from the owner
2-story cape cod-year round rental. Large front porch, 2-king beds, 2-full beds, one single bed and one and a half baths. Linens provided. Satellite tv and XM radio and wifi accessible. Tremendous sunrises and sunsets, park like double lot, propane heat and grill, kitchen utensils provided. Located between Niagara Falls and Rochester NY.
Very relaxed and comfortable.
Additional fees
Cleaning fee $30 per stay Fees for additional guests may apply.
50% non-refundable rental deposit required upon booking.
About the owner
About the owner
Jeff G.
Jeff G.
Response rate 85%
Response time Within a day
Calendar updated 9 days ago
Overall ratingNone
Lake Ontario/Niagara Falls-Year Round Cottage
Kendall, New York
Additional Location Information
Rural western new york between rochester and niagara falls. also near several state parks, wine country and beaches..It is a year round winterized cottage that is available for rent 365 days a year. Awesome sunrises and sunsets and magnificent night sky. There is 80 foot lake frontage on double lot with park like setting!
More About This Location
Beach or lakeside relaxation, Lake nearby, Waterfront
Getting There
Nearest airport: rochester new york, 35 miles
Car is essential
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Sergio Reyes wins Flying Pig Marathon
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Open Source IDE GAMBAS Reaches 3.0 137
from the that's-ok-I've-reached-37.0 dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
I've had a look at Gambas3 just now. You know what... it worked first time and was dead-fucking easy to get a gui running.
People knock Visual Basic for Applications (built into Excel/Word)... but so many quick and dirty applications get built with it because:
1. The component style of programming is extremely powerful - particularly when you can call upon very flexible and high level Office components. Especially when you have a good IDE - which VBA does.
2. It's shockingly easy to get your first application running (don't knock it... businesses run on the phrase "get it done now" - the first thing that works gets used).
3. You can give someone, for example, one MDB file and they click on it... and it runs (same with a spreadsheet). Easy to develop, easy to distribute.
Slag it off all you like. Microsoft does understand how to get people to use it. It's something that Free software developers never seem to learn. Maybe Gambas has?
Felson's Law: To steal ideas from one person is plagiarism; to steal from many is research.


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The COLUMBIA girls' Take Me There short-sleeve t-shirt may look and feel like a regular cotton tee, but its soft knit fabric is infused with Omni-Wick and Omni-Shade technologies to keep her comfortable under the summer sun. A colorful graphic print is featured on the front. Get your new COLUMBIA t-shirt today from Sports Authority. Size: XSMALL. Color: HOT CORAL. Age Group: Youth. Features and Benefits Fit: Relaxed--Full cut for ease of movement and versatility in layering. Fabric Type: Interlock--A type of double knit with a smooth surface on both sides Performance Technology: Columbia Omni-Wick--Incorporates a moisture management process where perspiration is efficiently drawn to the fabric surface where it can quickly evaporate. Performance Technology: Columbia Omni-Shade--Omni-Shade sun protection technology helps block damaging UV rays from reaching your skin, allowing for more carefree hours in the sun. UV Protection--Fabric is treated to block UV (ultraviolet) radiation from the sun, helping to prevent sunburn. Key Specs Fabric Content: 100% polyester Length: 18.5 Inches
$13 Go to
Sports Authority
Sports Authority
Size - 9 US Brand & Style - Columbia Woodburn Width - Wide (E,W) True Color - Fossil/Aqua Outsole Material - Man-Made Heel Height - 1.5 Inches Description - Columbia makes a wide variety of outdoor footwear for men and women: casual lace-up and slip-on shoes for athletic or weekend wear; travel and lifestyle shoes, including styles suitable for relaxed business occasions; wading boots for boating, fishing, and hunting; waterproof or water-resistant cold weather booths and shoes; rugged hiking and trail boots; multi-sport shoes; sandals and slides. The company also makes outstanding, value-packed warm winter boots for children. A number of Columbia models are part of their premier trademarked Titanium line, featuring advanced technologies and fabrics for the most outstanding all-weather outdoor performance. Based in Oregon and named for the Columbia River, the family-run company had its start back in 1937, evolving from the manufacture of hats to a business specializing in outdoor active apparel. Today, you can find Columbia products proudly worn worldwide, and the company dedicates itself not just to providing its customers with outstanding quality and performance but also to environmental awareness and responsibility. 1438241
$39 Go to
Enjoy the beauty of the backcountry in this stylish and protective Columbia pant.Active Fit sits at the waist and is straight through the hip and thigh.Omni-Shade UPF 50 fabrication protects your skin during outdoor activity by blocking harmful Ultraviolet A and Ultraviolet B rays (UVA and UVB).Omni-Shield technology creates a barrier that resists light precipitation and stains, keeping you clean and protected.High-performance fabric delivers plenty of stretch during activity.Back Up contoured waistband raises in back to provide complete coverage during bending and stretching.Inseam: Short 29.5, Regular 32.Body: 89% polyester, 11% elastane. Insert: 90% polyester, 10% elastane.Machine wash cold, tumble dry low.Imported. Measurements:Waist Measurement: 28 inOutseam: 42 inInseam: 32 inFront Rise: 10 inBack Rise: 14 inLeg Opening: 20 inProduct measurements were taken using size SM, inseam R. Please note that measurements may vary by size.
$65 Go to
Relax out there on the boat, Columbia has got your comfort covered.. Made of 100% polyester ripstop fabric. Omni-Shade® UPF 40 provides maximum protection for long hours in the sun. Omni-Wick® technology actively breathes and pulls moisture away from your skin. Antimicrobial treatment protects this product from bacterial growth. Mesh-lined vent at center back. Modern Classic fit for easy range of motion, casting will be a cinch. Imported. Vendor style: 1287051 100, 1287051 338. Columbias designs deliver the best apparel for days spent both on- and off-shore! Designed for cool comfort and functionality over the long haul, this performance button up is crafted from ultra-light ripstop fabric thats wicking and sun-shielding, with mesh-lined venting at center back. When you wear Columbia, the sun is no sweat off your back.
$40 Go to
Four pack of crew length thermal socks from Columbia features a reinforced heel/toe, a soft touch cotton blend, arch support and a stay up welt. 72% Polyester, 21% Cotton, 4% Rubber, 2% Rayon and 1% Spandex. Machine wash.
$13 Go to
Don the Columbia Baselayer Bug Shield Long Sleeve Top and you will be armed with a force field of protection against biting bugs. Thanks to the advanced Omni-Wick technology, the Columbia Baselayer Bug Shield Long Sleeve Top is also outfitted with superior moisture processing to keep you dry and comfortable, and the sleek mini-mesh fabrication keeps the fresh air constantly flowing through. The ergonomic design includes a drop tail in back for crucial coverage at lower back when you are bending over, and raglan sleeves are both flattering and movement friendly. Antimicrobial properties keep odors in check, wear after wear.
$69 Go to
Austin Kayak
Austin Kayak


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What Are The Pros And Cons Of Integrase Inhibitors
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
ls isentress integrase inhibitors the future for hiv meds ???Hi Dr Henry,l have been taking different hiv meds for the past 8 years, and its not much fun with the side effects of the meds, l am reading about isentress integtase inhibitors and would like to know your opinion, is this the new step in hiv...
Response from Keith Henry, M.D.
University of Minnesota, School of Medicine...Raltegravir is a promising new HIV treatment known as an integrase inhibitor. It has mostly been used in patients with resistant virus in complex regimens where it has performed well. It has to be taken Read more »
New Integrase inhibitor and lipodystrophy riskThere is a once a day integrase inhibitor with a non-PI booster coming up soon, isn't there? What... Read more »
integrase inhibitori know that integrase inhibitor are doing very very well..the results are very impressive given the... Read more »
Integrase Inhibitor '572 Tested Against Raltegravir-Resistant HIV... GlaxoSmithKline (GSK) has licensed an anti-HIV integrase inhibitor discovered by the Shionogi Corporation in Japan. Because of these arrangements, this drug has the complex code name S/GSK1349572 Read more »
Study of New ViiV HIV Integrase Inhibitor Yields Encouraging Early Results...Glasgow from November 7-11, it was reported by the National AIDS Treatment Advocates Project (NATAP) that the experimental integrase inhibitor S/GSK1349572 "proved a potent HIV suppressor at three doses tested in antiretroviral-naive people. ... Read more »
Cross-Resistance Between Integrase Inhibitors... HIV integrase inhibitors represent a new class of antiretroviral drugs that target a crucial post-transcriptional event in the life cycle of HIV. There Read more »
Comparing Two Integrase Inhibitors... It was more than a wish that integrase inhibitors became weaponry against HIV. We've waited a long time to get to this point and an even longer time to arrive at the position Read more »
Connect With Others
Integrase Inhibitor
Posted by Survivor...is hope and continued very active DRUG DISCOVERY! Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs Whitehouse Station, N.J.-based Merck and Foster City, Calif.-based Gilead... Read more »
Today's LA Times Article - Integrase Inhibitors
Posted by AnonymousVery hopeful! (Despite the sad title.) http://www.latimes.com/news/nationworld/nation/la-me-salvage2jan02,0,1565232,full.story?coll=la-home-headlines Read more »
More on New Meds
Posted by Survivor, 1 Reply...Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs February 9, 2006 Whitehouse Station, N.J.-based Merck and Foster City, Calif.-based Gilead Sciences Read more »
new medication news
Posted by DUDE, 1 Reply...powerful in the test tube. If developed into a drug, it would join an experimental but promising new class of drugs called integrase inhibitors. HIV drugs work at different steps in the process the virus goes through... Read more »
Resource Centers
Guides for People With HIV


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Three new US box arts for Wii. Can you handle it? First up here's George of the Jungle.
Watch out for that.. giraffe.
This is the blocky phenomenon, Blast Works: Build, Trade & Destroy.
Coming back after all these years, rat-tat-tat.
Last, but probably not least (I'm looking at you George), Dream Pinball 3D.
Everyone loves pinball.
3,022 news items
Keranu said:
That's a really rad cover for Dream Pinball.
The Hamburgler said:
Blast Works looks like the only one worth considering out of this lot.
Nintendoof said:
Blast Works looks cool.
Wiipaw said:
Hmmmm. Blast works actually sounds like fun.
Quartz said:
How is pinball rated E Ten and Up?
Master Foot said:
George of the jungle is definitely aimed at the younger crowd. What kind of title is that? "Search for the secret"? You know it's a real secret when the name of the secret is a secret.
TruBlu said:
Eh, none interest me. Dream Pinball MAYBE.
some random guy said:
E10 for pinball? Does esrb think pinball is violent now? Weird.
Project Ukulele - Possible Hint at Characters
Could it be?
Free to Play Pokemon Shuffle now available on 3DS eShop
Nintendo offers another micro-transaction based title
Gold Mario Amiibo is a Wal-Mart Exclusive
Get ready to shell out your coins
Area Effect Announces Izle for Wii U
Part action, part adventure, all cel-shaded
Nintendo Confirmed As Sponsor For APEX 2015
Another positive step for the Smash competitive scene
Majora's Mask 3D Collector's Edition Contains Skull Kid Figurine
Pre-orders are now open!
Ackk Studios Rings in the New Year with New Y2K footage
Starting the New Year with a bang!
Is Nintendo Making A New Wii U Gamepad?
Recent commercial may have leaked new GamePad model
Zeldathon Relief Announced
Pot smashing for a great cause
Why the Inclusion of The Duck Hunt Dog in Super Smash Bros. Was Brilliant
How the the most hated character in video games rose to the top of the Smash heap
Michael Jordan said:
No they're making it from the movie ... Speed Racer: The Video Game
daveoneal said:
Thanks Rob. I had no idea this one was published. I'm very happy about it! Yes, Jonathan, it is hard as all get-out, ... Street Fighter 2010: The Final Fight review
daveoneal said:
This was a very well-written review. Apparently Super Hexagon was developed by Terry Cavanagh (who made vvvvvv), so ... Cosmophony review
dirk said:
:p p ... TMNT: Smash Up
dirk said:
cool :p ... TMNT: Smash Up
Wii's World is not officially affiliated with Nintendo! (but they wish we were).


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M-commerce is expected to be a major source of revenue for cellular companies who are able to produce innovative and customer-centric products for the market. "Japan and Korea are very far ahead of the rest of the world with regards to innovation and consumer uptake of sophisticated data services," Tim Mitchell, vice president of marketing at IODA said.
View Full Article in:E-Commerce Times
Published in Brief:


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A once-in-a-lifetime moment of rock 'n' roll history comes to life in Million Dollar Quartet when this Broadway musical re-creates the day in 1956 when Elvis Presley, Johnny Cash, Jerry Lee Lewis and Carl Perkins sat down for a jam session at Sun Records Studio.
Click on your date and time to buy now, or call 1-866-983-4279
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Dec. 4, 1956.
In a rock 'n' roll moment so surreal you'd swear it was scripted for a movie, music superstars Elvis Presley, Jerry Lee Lewis, Carl Perkins and Johnny Cash came together in the afternoon for an impromptu jam session at Sun Record Studios in Memphis.
It was a moment that should never have happened. Presley, who had recorded for Sun Records, was now an RCA artist. Johnny Cash had just stopped by to listen to Carl Perkins' recording session (or pick up a check, depending on what version of the legend you believe). Jerry Lee Lewis was a relatively unknown performer outside of Memphis and was there just to provide some piano pizzaaz on Perkins' recording.
It was a one-in-a-million chance that these four rock 'n' roll superstars would meet and become, for a few hours, the Million Dollar Quartet.
More than 50 years later, the moment has been been musically brought to life in the hit Broadway show "Million Dollar Quartet" now playing at Harrahs Las Vegas.
We know exactly what was sung on that fateful December day at Sun Records because Jack Clement, the engineer for Perkins' session, recorded it. The session mainly featured gospel songs, but also a number of country and western songs by Bill Monroe, Ernest Tubb, Hank Snow and Gene Autry. Elvis' recent (at the time) hits "Don't Be Cruel" and "Love Me Tender," as well as Lewis' song "End of the Road."
"Million Dollar Quartet" the show takes a little more license, using that famous recording session as a springboard to imagine what it would sound like if Presley, Cash, Perkins and Lewis had the benefit of time to sing their greatest hits.
Featured songs in the show include "Blue Suede Shoes," "Real Wild Child," "Who DO You Love?," "Folsom Prison Blues," "I Walk the Line," "Hound Dog, "Great Balls of Fire," "Whole Lotta Shakin' Goin' On," "See You Later, Alligator," "Riders in the Sky," and more.
The show gives a nod to the original session with performances of "Peace In The Valley," "Brown Eyed Handsome Man," and "Down By The Riverside."
The Las Vegas production of the show features Tyler Hunter as Elvis Presley, Benjamin D. Hale as Johnny Cash, Martin Kaye as Jerry Lee Lewis and Robert Britton Lyons as Carl Perkins.
Kaye performed on the first world tour of "Million Dollar Quartet." Vegas audiences will recognize Hale who played Raoul in "Phantom—The Las Vegas Spectacular." Hunter previously performed as Elvis in "Legends in Concert in Atlantic City." Lyons orginated the role of Perkins and has starred in every production of the show.
It was 25 years before the recordings of that December day were rediscovered and released. And another six years after that before the complete jam session was made available to the public.
"Million Dollar Quartet" ensures that Dec. 4, 1956, will be a day you'll never forget.
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My friend Sam told me that her son Handsome loves it when she bakes my peanut butter and chocolate rusks. This was such a compliment for me, as kids are honest to a fault about what they like and dislike. After reviewing The Family … Continue reading
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I was with a group of people sitting around a table listening to them compare their debt levels. The majority of people in the group are spending more than they are earning. I listened as one explained how she was spending more on … Continue reading
ClemenGold recently held a competition which entailed submitting recipes to them and they would decide on a winner. I did not expect to win anything as I did not come up with a special recipe, but I did want to … Continue reading
It seems my blog has a small problem. My post for Sunday did not push itself through and my saved post for Choc Chip Scones published in the unedited format. So, this is the one that was meant to be live … Continue reading
The other day I was driving up the road and saw a gentleman pushing a shopping trolley. This is quite a common occurrence where I work as we have a second hand scrap metal dealer close to our office. The … Continue reading
One of the most beautiful cities we have visited is Siena when we were in Italy in 2010. Dave and I left Assisi and took a drive to Firenze (Florence). When we were on honeymoon, we missed out on two things … Continue reading
Rusks are to South Africans what biscotti are to Italians. They are a hard, twice baked biscuit (cookie to my American readers), that is most often served with a hot drink such as tea, and used for dipping. In South … Continue reading
These have to be the best rusks I have ever made. They combine my trail mix with a standard rusk recipe and they provide me with a feeling of being healthy with every bite. I find rusks so easy to make, … Continue reading
The other morning we woke up to discover that the water had been turned off at home due to some work that the water department was doing on the pipes down the road. Thankfully I had water in the upstairs … Continue reading
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Tango Lighting specializes in chic, contemporary lighting and brings together a diverse collection of pieces designed in Europe. The Buco Pendant redefines the classic hanging lamp with a design that passes light through a hole in its shade. Its bulb is focused facing upwards, causing the light to reflect off the inside of the shade.
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Hello to you here on Audiko.net! Use an opportunity to download a free Big Mike ringtones for your iPhone or mobile. Elect your favorite piece from your favorite audio track - 08 - Neyo-Beautiful Monster, Lox I Dont Give A Fuck, Playa Playa, or any other track. Then download the prepared Big Mike ringtones to your mobile, and enjoy Hip-Hop music by Big Mike every time your phone rings. If you prefer Hip-Hop or maybe Rap and Texas music, then you will probably like Jadakiss, Styles P, or Big Moe as well. For all who want a free Big Mike ringtone, we also recommend listening to Southern Rap, Houston, and . Depending on a phone model, you can download your tune both in the MP3 and m4a formats, played by both mobile phones and iPhones. Just select a track, and choose free Big Mike ringtones download option.
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Publications (59)114.41 Total impact
Article: Ent-Kaurane Diterpenoids from Croton Tonkinensis Induce Apoptosis in Colorectal Cancer Cells through the Phosphorylation of JNK Mediated by Reactive Oxygen Species and Dual-Specificity JNK Kinase MKK4.[Show abstract] [Hide abstract]
ABSTRACT: To search for new chemotherapeutic agents to treat colorectal cancer, we isolated a number of natural ent-kaurane diterpenoids from the plant Croton tonkinensis. Among them, only CeKDs with the 15-oxo-16-ene moiety induced the apoptosis of colorectal cancer cell lines Caco-2 and LS180. The active CeKD induced the activation of ERK and JNK, but the inactive ones induced that of ERK, but not that of JNK. It thus appears that JNK seemed to play an important role in the apoptotic activity of the active compounds. The dual-specificity JNK kinase MKK4 was activated in both colorectal cancer cells treated with the active CeKD, but MKK7 was not activated. Further, the active CeKD, but not the inactive one, enhanced the generation of intracellular reactive oxygen species (ROS) in both cells. CeKD-induced cell apoptosis and ROS generation, as well as JNK activation, were inhibited by the antioxidant N-acetyl-L-cysteine. These findings suggest that ROS stimulated the phosphorylation of JNK mediated by MKK4 and played a critical role in CeKD-induced apoptosis in colorectal cancer cells.Anti-cancer agents in medicinal chemistry 01/2014; DOI:10.2174/1871520614666140127111407
Article: Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.[Show abstract] [Hide abstract]
ABSTRACT: Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.Archives of Pharmacal Research 07/2013; 37(3). DOI:10.1007/s12272-013-0185-4 · 1.75 Impact Factor
Article: Anticancer Activity of Pristimerin in Epidermal Growth Factor Receptor 2-Positive SKBR3 Human Breast Cancer Cells.[Show abstract] [Hide abstract]
ABSTRACT: Pristimerin is a naturally occurring triterpenoid that causes cytotoxicity in several cancer cell lines. However, the mechanism of action for the cytotoxic effect of pristimerin has not been unexplored. The purpose of this study was to investigate the effect of pristimerin on cytotoxicity using the epidermal growth factor receptor 2 (HER2)-positive SKBR3 human breast cancer cell line. Pristimerin inhibited proliferation in dose- and time-dependent manners in cells. We found it to be effective for suppressing HER2 protein and mRNA expression. Fatty acid synthase (FASN) expression and FASN activity were downregulated by pristimerin. Adding of exogenous palmitate, the end product of de novo fatty acid synthesis, reduced the proliferation activity of pristimerin. The changes in HER2 and FASN expression induced by pristimerin altered the levels of Akt and mitogen-activated protein kinase (MAPK) phosphorylation (Erk1/2, p38, and c-Jun N-terminal kinase (JNK)). Pristimerin lowered the levels of phosphorylated mammalian target of rapamycin (mTOR) and its downstream targets such as phosphoprotein 70 ribosomal protein S6 kinase and 4E binding protein1. Pristimerin inhibited migration and invasion of cells, and co-treatment with the mTOR inhibitor rapamycin additionally suppressed these activities. Pristimerin-induced apoptosis was evaluated using Western blotting for caspase-3, -8, -9, and poly (ADP-ribose) polymerase expression and flow cytometric analysis for propidium iodide labeling. These results suggest that pristimerin is a novel HER2-downregulated compound that is able to decrease fatty acid synthase and modulate the Akt, MAPK, and mTOR signaling pathways to influence metastasis and apoptosis. Pristimerin may be further evaluated as a chemotherapeutic agent for HER2-positive breast cancers.Biological & Pharmaceutical Bulletin 01/2013; 36(2):316-325. DOI:10.1248/bpb.b12-00685 · 1.85 Impact Factor
Article: An ent-Kaurane Diterpenoid from Croton tonkinensis Induces Apoptosis by Regulating AMP-Activated Protein Kinase in SK-HEP1 Human Hepatocellular Carcinoma Cells.[Show abstract] [Hide abstract]
ABSTRACT: Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality worldwide. Traditional chemotherapy for HCC is not widely accepted by clinical practitioners because of its toxic side effects. Thus, there is a need to identify chemotherapeutic drugs against HCC. AMP-activated protein kinase (AMPK) is a biologic sensor for cellular energy status that acts a tumor suppressor and a potential cancer therapeutic target. The traditional Vietnamese medicinal plant Croton tonkinensis shows cytotoxicity in various cancer cells; however, its anticancer mechanism remains unclear. In this study, we determined whether the ent-kaurane diterpenoid ent-18-acetoxy-7β-hydroxy kaur-15-oxo-16-ene (CrT1) isolated from this plant plays a role as a chemotherapeutic drug targeting AMPK. CrT1 blocked proliferation in dose- and time-dependent manners in human hepatocellular carcinoma SK-HEP1 cells. CrT1 induced sub-G(1) arrest and caspase-dependent apoptosis. CrT1 activated caspase-3, -7, -8, -9, and poly(ADP-ribose) polymerase, and its effect was inhibited by z-VAD-fmk suppressing caspase-3 cleavage. CrT1 induced increases in p53 and Bax levels but decreased Bcl(2) levels. In addition, CrT1 resulted in increased translocation of cytochrome c into the cytoplasm. We showed that CrT1-activated AMPK activation was followed by modulating the mammalian target of rapamycin/p70S6K pathway and was inactivated by treating cells with compound C. Treatment with CrT1 and aminoimidazole carboxamide ribonucleotide (AICAR) synergistically activated AMPK. CrT1-induced AMPK activation regulated cell viability and apoptosis. These results suggest that CrT1 is a novel AMPK activator and that AMPK activation in SK-HEP1 cells is responsible for CrT1-induced anticancer activity including apoptosis.Biological & Pharmaceutical Bulletin 01/2013; 36(1):158-64. DOI:10.1248/bpb.b12-00873 · 1.85 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Highlights ► A new saponin and nine known compounds were isolated from Anemone rivularis. ► Structures were elucidated on the basis of spectroscopic analysis. ► New saponin can be utilized as a chemical marker for the taxonomy of A. rivularis.Biochemical Systematics and Ecology 10/2012; 44:270–274. DOI:10.1016/j.bse.2012.03.017 · 1.17 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: The emergence of the H1N1 swine flu pandemic has the possibility to develop the occurrence of disaster- or drug-resistant viruses by additional reassortments in novel influenza A virus. In the course of an anti-influenza screening program for natural products, 10 xanthone derivatives (1-10) were isolated by bioassay-guided fractionation from the EtOAc-soluble extract of Polygala karensium. Compounds 1, 3, 5, 7, and 9 with a hydroxy group at C-1 showed strong inhibitory effects on neuraminidases from various influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, these compounds reduced the cytopathic effect of H1N1 swine influenza virus in MDCK cells. Our results suggest that xanthones from P. karensium may be useful in the prevention and treatment of disease by influenza viruses.Bioorganic & medicinal chemistry letters 04/2012; 22(11):3688-92. DOI:10.1016/j.bmcl.2012.04.028 · 2.65 Impact Factor
Article: Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.[Show abstract] [Hide abstract]
ABSTRACT: AMP-activated protein kinase (AMPK) is a sensor of cellular energy status found in all eukaryotes. Recent studies indicate that AMPK activation strongly suppresses cell proliferation in tumor cells, which requires high rates of protein synthesis and de novo fatty acid synthesis for their rapid growth. Pomolic acid (PA) has been previously described as being active in inhibiting the growth of cancer cells. In this study, we investigated PA activated AMPK, and this activity was related to proliferation and apoptosis in MCF7 breast cancer cells. PA inhibited cell proliferation and induced sub-G(1) arrest, elevating the mRNA levels of the apoptotic genes p53 and p21. PA activated caspase-3, -9, and poly(ADP-ribose) polymerase, and this effect was inhibited by z-VAD-fmk. AMPK activation was increased by treating cells with PA, inactivated by treating cells with a compound C, and co-treatment consisting of PA and aminoimidazole carboxamide ribonucleotide (AICAR) synergistically activated AMPK. These anti-cancer potentials of PA were accompanied by effects on de novo fatty acid synthesis as shown by the decreased expression of fatty acid synthase, and decreased acetyl-CoA carboxylase activation and incorporation of [(3)H]acetyl-CoA into fatty acids. In addition, PA inhibited key enzymes involved in protein synthesis such as mammalian target of rapamycin (mTOR), 70 kDa ribosomal protein S6 kinase (p70S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1). These results suggest that PA exerts anti-cancer properties through the modulation of AMPK pathways and its value as an anti-cancer agent in breast cancer therapy.Biological & Pharmaceutical Bulletin 01/2012; 35(1):105-10. DOI:10.1248/bpb.35.105 · 1.85 Impact Factor
Article: Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis[Show abstract] [Hide abstract]
ABSTRACT: Breast cancer is the most common malignant tumor in women these days accounting for approximately 24% of all cancer. During our screening program searching for cytotoxic materials from natural products, two new symmetric dimers of ent-kaurane diterpenoid, crotonkinensins C (1) and D (2), with connectivity at C-17 were isolated from the leaves of the Vietnamese endemic medicinal plant Croton tonkinensis. Their structures were determined on the basis of physicochemical and spectroscopic data. Compound 2 showed a potent cytotoxic activity against MCF-7, tamoxifen-resistant MCF-7 (MCF-7/TAMR), adriamycin-resistant MCF-7 (MCF-7/ADR), and MDA-MB-231 breast cancer cell lines.Bioorganic & medicinal chemistry letters 12/2011; 22(2):1122-4. DOI:10.1016/j.bmcl.2011.11.116 · 2.65 Impact Factor
Article: Inhibitory effect of ursane-type triterpenoids from Weigela subsessilis on RANKL-induced osteoclast differentiation[Show abstract] [Hide abstract]
ABSTRACT: Osteoclasts play an important role in bone metabolism by resorbing the bone matrix. Thus, the compounds inhibiting osteoclasts can treat bone diseases such as osteoporosis. Among the 8 triterpenoids tested, we show that Ilekudinol B isolated from the plant Weigela subsessilis inhibits receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis from bone marrow-derived monocyte/macrophage cells in a dose-dependent manner, whereas it has no significant effect on osteoblast differentiation. Furthermore, Ilekudinol B attenuates the induction of nuclear factor of activated T cells (NFAT) c1 and osteoclast-associated receptor (OSCAR) expression. Our results indicate that Ilekudinol B has the potential to inhibit osteoclast formation by attenuating the signaling cascades associated with RANKL.
[Show abstract] [Hide abstract]
ABSTRACT: A series of 2-phenylbenzothiazoles has been synthesized either by i) condensation of different aromatic aldehydes with 2-aminothiophenol or ii) condensation of N-(2-chlorophenyl)benzothioamides in KOH catalyzed by potassium fericyanide. The structures of synthesized compounds were confirmed by IR, MS, and 1H-NMR. The results of biological activity screening showed that six compounds including 2-phenylbenzothiazol (1a), 2-(2-chlorophenyl)benzothiazole (1b), 2- (3-chlorophenyl)benzothiazole (1c), 2-(4-hydroxyphenyl)benzothiazole (1e), 2-(4-dimethylaminophenyl)benzothiazole (1h) and 2-(2,3,4-trimethoxyphenyl)benzothiazole (1i) exhibited significant antibacterial activities; two compounds (1a, 1e) exhibited antifungal activities. Especially, 1e showed considerable antimicrobial activity against both A. niger and F. oxysporum. The brominated derivative of 1e displayed extended spectrum against all four bacterial strains tested with lower MIC values. In vitro cytotoxicity of the synthesized compounds was evaluated on three cancer cell lines (A549, HT1080, MCF7-MDR). The results indicated that three compounds (1e, 1g, 1i) exhibited significant cytotoxic activity on A549 and MCF7-ADR cells (IC50, 10.07-13.21μg/ml). Brominated and nitrated derivatives (1k, 1l, respectively) of 1e exhibited even more potent cytotoxicity.Medicinal Chemistry 02/2011; 7(2):127-134. DOI:10.2174/157340611794859361 · 1.39 Impact Factor
Natural Product Sciences 01/2011; 17(2):94-97 (.
[Show abstract] [Hide abstract]
ABSTRACT: A series of 2-phenylbenzothiazoles has been synthesized either by i) condensation of different aromatic aldehydes with 2-aminothiophenol or ii) condensation of N-(2-chlorophenyl)benzothioamides in KOH catalyzed by potassium fericyanide. The structures of synthesized compounds were confirmed by IR, MS, and (1)H-NMR. The results of biological activity screening showed that six compounds including 2-phenylbenzothiazol (1a), 2-(2-chlorophenyl)benzothiazole (1b), 2-(3-chlorophenyl)benzothiazole (1c), 2-(4-hydroxyphenyl)benzothiazole (1e), 2-(4-dimethylaminophenyl)benzothiazole (1h) and 2-(2,3,4-trimethoxyphenyl)benzothiazole (1i) exhibited significant antibacterial activities; two compounds (1a, 1e) exhibited antifungal activities. Especially, 1e showed considerable antimicrobial activity against both A. niger and F. oxysporum. The brominated derivative of 1e displayed extended spectrum against all four bacterial strains tested with lower MIC values. In vitro cytotoxicity of the synthesized compounds was evaluated on three cancer cell lines (A549, HT1080, MCF7-MDR). The results indicated that three compounds (1e, 1g, 1i) exhibited significant cytotoxic activity on A549 and MCF7-ADR cells (IC(50), 10.07-13.21 μg/ml). Brominated and nitrated derivatives (1k, 1l, respectively) of 1e exhibited even more potent cytotoxicity.Medicinal chemistry (Shāriqah (United Arab Emirates)) 01/2011; 7(2):127-34. · 1.64 Impact Factor
Article: Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis.[Show abstract] [Hide abstract]
ABSTRACT: Corosolic acid is one of the triterpenoids present in the leaves of Weigela subsessilis. The antidiabetic activity of corosolic acid has been reported previously, but to date, the anticancer effects on gastric cancer have been poorly studied. In this study, corosolic acid showed growth inhibition on SNU-601 human gastric cancer cells, with an IC₅₀ value of 16.9 ± 2.9 μM. Corosolic acid also triggered the activation of caspase-3 and poly (ADP-ribose) polymerase, while it was recovered by Z-VAD-FMK. Moreover, the cell growth/apoptosis activities of corosolic acid were regulated by the AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signals. These results showed that corosolic acid-mediated AMPK activation leads to inhibition of mTOR, thus providing a possible mechanism of action of corosolic acid in the inhibition of cancer cell growth and the induction of apoptosis.Phytotherapy Research 12/2010; 24(12):1857-61. DOI:10.1002/ptr.3210 · 2.40 Impact Factor
Article: Protein Tyrosine Phosphatase 1B Inhibitory Activity of 24-Norursane Triterpenes Isolated from Weigela subsessilis[Show abstract] [Hide abstract]
ABSTRACT: During the screening effort to discover new types of protein tyrosine phosphatase 1B (PTP1B) inhibitors, it was found that a MeOH extract of the leaves and stems of Weigela subsessilis (Caprifoliaceae) inhibited the enzyme activity. By means of an in vitro bioassay-guided fractionation on the MeOH extract, two 24-norursane triterpenes, ilekudinol A (1) and ilekudinol B (2), were isolated as active metabolites. Compounds 1 and 2 inhibited PTP1B with IC(50) values of 29.1 ± 2.8 and 5.3 ± 0.5 μM, respectively. Kinetic studies suggest that both 1 and 2 are non-competitive inhibitors of PTP1B. The findings indicate that the free carboxyl group at C-28 in this type of triterpenes plays a critical role in the inhibition of PTP1B.Phytotherapy Research 11/2010; 24(11):1716-9. DOI:10.1002/ptr.3203 · 2.40 Impact Factor
Article: Synthesis and Biological Evaluation of A Series of (Benzo[d]thiazol-2-yl)cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamides.[Show abstract] [Hide abstract]
ABSTRACT: A series of benzothiazole derivatives including N-(benzo[d]thiazol-2-yl)cyclohexanecarboxamides (2a-g) and N-(benzo[d]thiazol-2-yl)cyclohexancarbothioamides (3b-d) have been synthesized and evaluated for cytotoxic and antimicrobial activities. Two compounds including N-(6-ethoxybenzo[d]thiazol-2-yl)cyclohexanecarboxamide (2c) and N-(6-ethoxybenzo[d]thiazol-2-yl)cyclohexanecarbothiamide (3c) demonstrated significant cytotoxicity against three cancer cell lines (A549, MCF7-MDR and HT1080) while most of compounds exhibited moderate inhibitory effects on the growth of Staphyllococcus aureus and some other fungi.Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2010; 6(3):159-64. DOI:10.2174/1573406411006030159 · 1.64 Impact Factor
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ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option.ChemInform 03/2010; 41(13). DOI:10.1002/chin.201013203
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ABSTRACT: Silent information regulator two ortholog 1 (SIRT1) is a member of the sirtuin deacetylase family of enzymes that removes acetyl groups from the lysine residues in histones and other proteins. It has been suggested that SIRT1 inhibitors might be beneficial in the treatment of cancer and neurodegenerative diseases. Bioassay-guided fractionation of the MeOH extract of the leaves of CROTON TONKINENSIS resulted in the isolation of a new ENT-kaurane diterpenoid (1) along with 11 known compounds (2- 12). The structure of the new compound 1 was determined to be ENT-11 alpha-acetoxy-7 beta-hydroxykaur-16-en-15-one based on spectroscopic analyses. Compounds 3, 4, 6- 9, 11, and 12 exhibited SIRT1 inhibitory activity in an IN VITRO assay, with IC (50) values ranging from 16.08 +/- 0.11 to 44.34 +/- 2.32 microM. This is the first report showing the potential of ENT-kaurane diterpenoids as a new class of natural SIRT1 inhibitors.Planta Medica 02/2010; 76(10):1011-4. DOI:10.1055/s-0029-1240863 · 2.35 Impact Factor
Article: Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells.[Show abstract] [Hide abstract]
ABSTRACT: Overexpression/amplification of human epidermal growth factor receptor (HER)2/neu (erbB-2) oncogene plays a causal role in carcinogenesis and correlates with a poor clinical prognosis. However, little is known about HER2 in gastric cancer. In this study, we explored the pharmacological activities of natural triterpenoid corosolic acid (CRA) in HER2 signaling and its role in gastric cancer development and progression. In this study, CRA dramatically inhibited HER2 expression in a dose- and time-dependent manner, effectively inhibited cell proliferation, and induced G(0)/G(1) arrest through the induction of p27(kip1) and cyclin D(1) down-regulation. CRA exposure enhanced apoptotic cell death, as confirmed by caspase-3 and poly (ADP-ribose) polymerase cleavage activities. CRA inhibited signaling pathways downstream of HER2, including phospho-proteins such as Akt and Erk. In addition, CRA combined with adriamycin and 5-fluorouracil enhanced this growth inhibition, but not with docetaxel and paclitaxel. These findings demonstrate that CRA suppresses HER2 expression, which in turn promotes cell cycle arrest and apoptotic cell death of gastric cancer cells, providing a rationale for future clinical trials of CRA in the treatment of HER2-positive gastric cancers.Biological & Pharmaceutical Bulletin 01/2010; 33(6):931-7. DOI:10.1248/bpb.33.931 · 1.85 Impact Factor
Article: 24-Hydroxyursolic Acid from the Leaves of the Diospyros kaki (Persimmon) Induces Apoptosis by Activation of AMP-activated Protein Kinase[Show abstract] [Hide abstract]
ABSTRACT: There are multiple lines of evidence that persimmon extract and its constituents have potent antitumor activity against human cancer cells. However, the molecular mechanisms of 24-hydroxyursolic acid, a triterpenoid found in persimmon, on antitumor activities are not yet understood. Here, we demonstrate that 24-hydroxyursolic acid inhibited cell proliferation, strongly activated AMP-activated protein kinase (AMPK) and mediated critical anticancer effects by inhibition of cyclooxygenase (COX-2) expression in HT-29 cells. In addition, 24-hydroxyursolic acid induced cellular apoptosis by activation of poly(ADP-ribose) polymerase (PARP), caspase-3, and phosphorylation of p53 at Ser15. It also strongly induced DNA fragmentation in HT-29 cells and thereby significantly inhibited colony formation of HT-29 cells in soft agar. In addition, 24-hydroxyursolic acid blocked the EGF-induced ERKs phosphorylation and led to the inhibition of AP-1 activity and cell transformation in JB6 CL41 cells. Collectively, these findings are the first to reveal a molecular basis for the anticarcinogenic action of 24-hydroxyursolic acid and might account for the reported chemopreventive and chemotherapic effects of persimmon extracts.Planta Medica 12/2009; 76(7):689-93. DOI:10.1055/s-0029-1240678 · 2.35 Impact Factor
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ABSTRACT: Bioassay-guided fractionation of the EtOAc extract of the stem bark of Erythrina abyssinica (Leguminosae) resulted in the isolation of three new (1-3), along with 12 known (4-15) pterocarpan derivatives. Their chemical structures were determined by physicochemical and spectroscopic data analysis (IR, UV, [alpha](D), CD, 1D and 2D NMR, and MS data). All the isolates were evaluated for their inhibitory effects on protein tyrosine phosphatase-1B (PTP1B), as well as their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), adriamycin-resistant MCF7 (MCF7/ADR) and MDA-MB-231 breast cancer cell lines. Compounds which exhibited PTP1B inhibitory activity (IC(50) values ranging from 4.2+/-0.2 to 19.3+/-0.3 microM) showed strong cytotoxic activity (IC(50) values from 5.6+/-0.7 to 28.0+/-0.2 microM). Our data suggested that pterocarpans could be considered as new anticancer materials by PTP1B inhibition.Bioorganic & medicinal chemistry letters 12/2009; 19(23):6745-9. DOI:10.1016/j.bmcl.2009.09.108 · 2.65 Impact Factor
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AboutA web log for all fans of Walt Disney, The Disney Company, and its many products. Using the theories behind Walt Disney's family oriented entertainment and education, this blog is intended to be a safe read for the whole family. Proud to be a part of Quality Will Out Omnimedia. The Disney Blog is not affiliated with The Walt Disney Company in any way. All Disney parks, attractions, lands, shows, event names, etc. are registered trademarks of The Walt Disney Company. The Disney Blog is affiliated with LaughingPlace.com, the number one Disney Fan site on the internet. Please see creative commons license at the bottom of this page for copyright information. All content on this website is my own and does not necessarily represent the views of my employer or anyone else on the planet. The Disney Blog is supported by advertising and some of the links on this site and in product reviews are revenue share affiliate ads. I also do accept product for review and to give away as prizes. However, I compose all my editorial separate from any decision regarding advertising or affiliate links. YMMV.
Tag Archives: ariel
New Key Image Concept Art for Fantasyland Expansion
Walt Disney World has released three new images that capture the vision of the Fantasyland Expansion that has already begun to open at the Magic Kingdom. The first image is a new view of the whole land as it will … Continue reading
Posted in Walt Disney World Tagged ariel, Art, belle, concept art, fantasyland expansion, key image, magic kingdom, new fantasyland, signature image, storybook circus, Walt Disney World, WDW Comments Off
Magic Kingdom Update – Rolling Through The Park (Part 1)
Have a long photo update from Magic Kingdom at Walt Disney World this week. At least two parts, possibly three. So let's get right to it. Click to Embiggen. Cinderella Castle is looking particularly lovely after the holiday lights have … Continue reading
Mural for Little Mermaid Attraction – Behind the Scenes with Disney's Imagineers
Part of the Fantasyland expansion in the Magic Kingdom is a dark ride based on the one of Walt Disney Animation's classics – The Little Mermaid. I'm very happy that this dark ride is returning a tradition we associate with … Continue reading
Posted in Walt Disney World Tagged ariel, chris beatty, fantasyland, fantasyland expansion, imagineer, Imagineering, magic kingdom, the little mermaid, Walt Disney World, WDI, WDW 3 Comments
Behind the scenes of Under the Sea ~ Journey of the Little Mermaid at Magic Kingdom
Disney has released a new video hosted by Imagineer Chris Beatty who gives us a sneak peek at the making of Under the Sea ~ Journey of the Little Mermaid. The video includes some never-before-seen sketches, artist renderings, attraction maps … Continue reading
Posted in Walt Disney World Tagged ariel, attraction, California Adventure, concept art, DCA, dhs, imagineer, little mermaid ride, magic kingdom, meet and greet, mk, model, one man's dream, preview, prince eric, rock work, submarine ride, the little mermaid, tilde, Travel Planning, under the sea, under the sea journey of the little mermaid, ursula, video, Walt Disney World, WDI, WDW 7 Comments
The Little Mermaid – Ariel's Undersea Adventure Building Timelapse
I love a good timelapse video. As far as interesting videos in Disney parks history, this one is fairly minor. But for those who can't wait for the opening of The Little Mermaid – Ariel's Undersea Adventure inside Disneyland's second … Continue reading
Posted in Disneyland Tagged ariel, ariel's undersea adventure, California Adventure, DCA, Disneyland, the little mermaid, timelapse, timelapse video, tlm:aua 6 Comments


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|Laennec 36 rue Seignemartin, 8th arr., 69008 Lyon, France (0.7 miles from Mermoz-Pinel Metro Station )
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|Mercure Lyon Lumière 69 Cours Albert Thomas, 3rd arr., 69003 Lyon, France (1.5 miles from Mermoz-Pinel Metro Station )
Score from 147 reviews: Very goodJust 650 ft from Sans Souci Metro stop, this Mercure hotel is a 10-minute Metro ride from the center of Lyon and the Part-Dieu Train Station. It offers stylish rooms with a movie theme. More…
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|Appart'Hotel Odalys Bioparc 60, Avenue Rockefeller, 8th arr., 69008 Lyon, France (0.7 miles from Mermoz-Pinel Metro Station )
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|Hôtel Lacassagne 245 Avenue Lacassagne, 3rd arr., 69003 Lyon, France (1.0 miles from Mermoz-Pinel Metro Station )
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Perfect for photographers ready to make the move to digital SLR photography, the EOS Rebel T3 delivers beautiful photos and video, speed, simplicity and fun. It features a 12.2 Megapixel CMOS Image Sensor and Canon DIGIC 4 Image Processor for richly detailed images and quick camera response. It has Canon's amazing 63-zone, Dual-layer metering for accurate exposures and features Canon's Basic+ function, HD video recording and Live View shooting, plus a convenient in-camera Feature Guide. Technology for Outstanding Images. 12.2 Megapixel CMOS (APS-C) sensor and DIGIC 4 Image Processor for high image quality and speed. Canon's CMOS (Complementary Metal Oxide Semiconductor) sensor captures images with exceptional clarity and tonal range, and offers the most pixels in its class. It offers many of the same new technologies to maximize each pixel's light gathering efficiency that were first seen with the professional EOS-1D Mark III model. It's an APS-C size sensor (22.2 x 14.8mm), and there's an effective 1.6x increase in the lens's marked focal length when attached. DIGIC 4 Image Processor The improved DIGIC 4 Image Processor ensures that images are captured, processed and saved with remarkable speed. The EOS Rebel T3 DSLR's new 3:2 multiple aspect ratio, in-camera RAW image processing, creative filters, image resizing and provided S2 and S3 image-recording quality are all possible thanks to the DIGIC 4 Image Processor. With dazzling results, the new DIGIC 4 Image Processor al
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A traffic stop in Lancaster County Sunday led to the seizure of nearly 39 pounds of marijuana and the arrest of two men from Oregon.
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The driver, Gregory T. Miller, 43, of Tualatin, Ore. and a passenger Britt J. Bones, 38, of Eagle Point, Ore. were lodged in the Lancaster County Corrections each on a charge of possession of marijuana with intent to deliver.
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Originally written on Pro Sports Daily | Last updated 11/8/14
New Orleans Pelicans second-year backup forward Darius Miller could miss up to 12 weeks after suffering a stress fracture in his left foot that required surgery the team announced Monday. Miller 6 feet 8 235 pounds had been experiencing discomfort in his foot during recent volunteer workouts before team doctors diagnosed the injury. Although he is set to begin rehabilitation work in New Orleans on Tuesday Miller is expected to miss all of training camp that is set to begin on Oct. 1. As a rookie last season Miller played in 52 games and averaged 2.3 points. Last season Miller was the only New Orleans player on the roster to draw a NBA Development League assignment. He played in 11 games for the Iowa Energy which included eight starts and averaged 9.9 points 3.5 rebounds 1.6 assists in 27.2 minutes before he was recalled in January. During summer league play in Las Vegas during July Miller showed promise as a perimeter scorer at small forward. But he was still expected to have dif...
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The Bride Bargain - eBook
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|Format: DRM Free ePub
Vendor: Barbour Publishing
Publication Date: 2009
Availability: In Stock
Series: Prairie Promises
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Prairie Promises TrilogyKelly HakeBarbour Publishing / 2011 / Trade Paperback$14.99 Retail:3.5 Stars Out Of 5 4 Reviews
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The Bride Backfire, Prairie Promises Series #2Kelly Eileen HakeBarbour Publishing / 2013 / Trade Paperback$4.49 Retail:
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The Bartered Bride Collection: 9 Historical Stories of Arranged MarriagesCathy Hake, JoAnn Grote, Kelly HakeBarbour Publishing / 2012 / Trade Paperback$6.99 Retail:4.5 Stars Out Of 5 9 Reviews
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Author Bio
Kelly Eileen Hake received her first writing contract at the tender age of seventeen and arranged to wait three months until she was able to legally sign it. Since that first contract a decade ago, shes fulfilled twenty contracts ranging from short stories to novels. In her spare time, shes attained her BA in English literature and composition, earned her credential to teach English in secondary schools, and went on to complete her MA in writing popular fiction.
Writing for Barbour combines two of Kellys great loveshistory and reading. A CBA bestselling author and member of American Christian Fiction Writers, shes been privileged to earn numerous Heartsong Presents Readers Choice Awards and is known for her witty, heartwarming historical romances. A newlywed, she and her gourmet-chef husband live in Southern California with their golden lab mix, Midas!
Product Reviews
wfnrenSt Cloud, FLAge: 55-65Gender: female5 Stars Out Of 5A fun book, enjoyable to readOctober 9, 2013wfnrenSt Cloud, FLAge: 55-65Gender: femaleQuality: 5Value: 5Meets Expectations: 5This review was written for Bride Bargain, Prairie Promises Series #1 (rpkgd).Clara Field and her Aunt Doreen Edgerly are headed for Oregon for a new start in life. Doreen married a very cruel man so she would be able to raise Clara after her parents were killed. She didn't know how bad a life she would have with that man and he detested Clara. Now it is Clara's turn to do something for her aunt, and that is to start over. It is unusual for a wagon train to take on a wagon with no man but there is a man who has agreed to help them in exchange for meals so they are headed for Oregon. Their wagon isn't the best and they have a very ornery oxen who likes to eat leather and wander off. These things cause a lot of delays for the wagon train and they eventually find themselves left behind to go the rest of the way on their own, two women on their own. They make it to Buttonwood, NE two days after the wagon train passed through.
They don't know what they are going to do when Josiah Reed, owner of the Buttonwood Feed and Dry Goods Store offers them a place to live in return for them taking care of his house and fixing meals along with helping out at the store when he needs help. Clara and Doreen have no choice but to take him up on his offer. Josiah has plans to leave town for a while after his son arrives to oversee things, this is where the bride bargain comes in, he wants Saul to stay in Buttonwood and not return to Baltimore. As a reward for getting Saul married to one of the five single girls in town (six counting herself, but she isn't including herself in the running, although Josiah is) then she and her aunt can have his house and he will build himself another one. It's rather interesting the way she tries to get Saul alone with all of the girls, especially since two of the families don't get along AT ALL.
This is a nice story and really kept me interested. Kelly did a good job and I'm looking forward to reading the next two books, The Bride Backfire and The Bride Blunder, knowing Kelly's books they'll be just as enjoyable as this one was.
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Powder Eye Shadow Single - Silver 0.07 oz from Annemarie Borlind may accentuate your eyes. This product is available in powder form for application purposes. Studies reveal that eye shadow may be in cream or powder form. Clinical trials claim that powder form eye shadows may be easier to apply' blend' and spread' as compared to cream based eye shadows.
This eye shadow from Annemarie Borlind could beautify your eyes' and may also bring out your eye color.
This product contains an optimal blend of ingredients that could nourish and revitalize the skin. This product contains the jojoba extract' which is derived from the jojoba shrub commonly found in northern Mexico and the southwestern United States. Scientists suggest that jojoba could act as an emollient' and may potentially nourish the skin from within. The product may also contain bisabolol' which may display anti-irritant' anti- anti-inflammatory and anti-microbial properties to help enhance skin health.
This product is ophthalmologically tested' and is free from any animal extracts. Get Powder Eye Shadow Single - Silver 0.07 oz from Annemarie Borlind to give your look finesse and class.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose' treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Talc' distarch phosphate' magnesium stearate' lauroyl lysine' squalane' simmondsia chinensis (jojoba) seed oil' phenoxyethanol' cetearyl ethylhexanoate' bisabolol' hydrogenated palm glycerides' hydrogenated palm kernel glycerides' ascorbyl palmitate' hydrogenated palm glycerides citrate' tocopherol' lecithin.
May contain:
Mica' ci 77499 (iron oxides)' ci 77007 (ultramarines)' ci 77288 (chromium oxide greens)' ci 77491 (iron oxides)' ci 77891 (titanium dioxide)' ci 77742 (manganese violet)' ci 77492 (iron oxides)' ci 77489 (iron oxides)' silica' ci 77510 (ferric ferrocyanide).
Use as directed by a healthcare professional before use.
Consult a healthcare professional before use.
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P.O. Box 19125
Arlington, TX 76019
Phone: 817-272-2101
Staff Bio
Mirna Gonzalez is Associate Vice President for Budget and Public Policy at the University of Texas (UT) at Arlington, a comprehensive, high research activity university with enrollment of 33,400 students.
Ms. Gonzalez frequently partners with other universities, in particular research and emerging research universities within the UT System, on the development and analysis of key public policy issues. Prior to joining UT Arlington, she was assistant vice chancellor for government relations with the University of Texas System. In this key role, she served as an advisor to the Vice Chancellor for Governmental Relations and the Controller on the development of the UT System's funding priorities for the 2006-07 and 2008-09 biennial budget cycles.
Prior to joining the University of Texas System, she served as the manager of the Higher Education team with the Texas Legislative Budget Board (LBB), the agency that develops budget and policy recommendations for the Texas Legislature. During her 8 years with the LBB she specialized in developing formula funding recommendations for the state's institutions of higher education.
Ms. Gonzalez has an MBA from the University of Texas at San Antonio and a BBA from the University of Texas at Austin.
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OP Member
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Bluetooth headset: Platronics Voyager Legend
Rom: GoldenEye 28 (but this problem also occured on stock 4.2.2 TW)
Issue: Google Voice typing doesn't work with bluetooth headset.
When it's not connected to bluetooth, it works fine if I speak into the mic. When it IS connected to the bluetooth headset, it only works/recognize what I'm saying when I speak only into the phone's mic. The Bluetooh headset mic doesn't kick in during google voice typing. The headset works fine in Google Now or Google Voice search. Just the keyboard portion when I'm in other apps and trying to send off a text..
Any help would be appreciated...
Last edited by AxlxA; 29th April 2014 at 02:22 AM.