text:
Someone of asian decent that acts black or "ghetto"
"wazup ma asian Jigga!"
UR MOM tarafından 19 Şubat 2003, Çarşamba
a japanese person who thinks there black and pretty darn gangsta. but really there just a wanna-be
Your not a gangsta, take your jigga self back to japan and make some fucking video games!
nickstaaaaaaaa tarafından 3 Nisan 2006, Pazartesi
A measuring tool for shots used by Bartenders
First pour your gin into a jigga(jigger)to measure out the appropriate amount of alcohol to mix a dirty martini.
Shocka Zoe tarafından 23 Haziran 2005, Perşembe
Its another word for a male friend.
A guy greets a male friend "What's up jigga?"
Jessica tarafından 18 Kasım 2004, Perşembe
A Jewish guy whos really good at rapping. Could be mistaken for a Nigga.
Fuckface: Man that black guy is really good at rapping. i wonder where he gets his skills?
Smart guy who knows what he's talkin bout: Dude he's a Jigga, and he graduated out the Shul.
Smart guy who knows what he's talkin bout: Dude he's a Jigga, and he graduated out the Shul.
Mattmanjr tarafından 6 Kasım 2007, Salı
A fly Jewish person who acts as if they were black.
Ezra balled 3 girls, what a Jigga.
Adam Zeldin tarafından 20 Nisan 2006, Perşembe
a wigga that is jewish.
Rosa: man your mom's matzo balls suck!
Phil: jigga please!
Phil: jigga please!
Phil "honky" tarafından 11 Ekim 2005, Salı


text:
How to avoid mildew on peas?
My peas were drooping over off the trellis, pulling it down, so I ran twine around them to hoist them up But now I'm worried that they might be tied too close together and, with all the rain and damp weather we've been having, this is going to cause mildew before they're ready to harvest. I planted them about 2" apart, btw. This isn't too close, is it? It's what I've always done, but the growth is exuberant this year. I'm wondering if there's a way to avoid this, and if there's anything I can do about it now before mildew starts. I can untie them, but I don't know how I'd keep them from falling over then. Any ideas?
And if they do get powdery mildew, which they always eventually do, does that stay in the soil after the vines are pulled out, affecting a following crop?
Thank you.
You could try spraying the biological antagonist Serenade, which in my experience works pretty well against powdery mildew even as a curative agent so it would definitely work as a preventative. It's less effective against more aggressive fungal diseases like white mould.

subset: commoncrawl


text:
Rob Schneider Selects Full Sail as Host Location for Production of New Comedy Series
Actor, comedian, director, and screenwriter Rob Schneider, best known for his roles on "SNL," Deuce Bigalow, The Waterboy, and Big Daddy, has selected Full Sail University as the host location and production headquarters for the filming of his new eight-episode independently-produced comedy series, "Real Rob," beginning in March 2014.
"Full Sail University is unique in that the campus has everything a major studio offers," said Schneider. "The facilities truly are state-of-the-art and I couldn't be happier with my choice in filming here."
"Real Rob," which is loosely based on the actor's life, will feature Schneider and his real-life spouse, writer-producer Patricia Azarcoya Schneider, as themselves in the half-hour-long, single camera situation comedy. The series was co-written by the couple alongside fellow comedian Jamie Lissow. Select students and graduates of Full Sail University will have the opportunity to gain hands-on experience in various roles behind the scenes during the show's production.
"On behalf of Full Sail University, we are proud to welcome Rob Schneider and his team to campus for the production of his latest project, 'Real Rob,'" said Full Sail University's Vice President of Academic Affairs, Dave Franko."One of the founding principles of our education has always been to provide our students with real-world industry experience. This collaboration will allow for tremendous learning opportunities within our university, while highlighting the greater Orlando film community."
"We are thrilled to be working with the production team of 'Real Rob,'" said Orlando Film Commissioner, Sheena Fowler. "It's a win-win for the production, the students and our experienced infrastructure in Orlando."
Schneider was an honored guest and speaker last week as part of Full Sail University's Fifth Annual Hall of Fame Week. He discussed the vision and anticipated production of his new series during a conversation with students.
Related Stories
March 31, 2015
Workshops and Reviews: More Highlights From the Sixth Annual Hall of FameStudents share their favorite moments from the Sixth Annual Hall of Fame workshops and reviews. Read More...
March 27, 2015
Highlights From the Sixth Annual Hall of FameWe put together a collection of our favorite moments and photos from Full Sail's Sixth Annual Hall of Fame Week. Read More...


text:
Updates for Social Enterprise
A new delivery truck for Healthy Corners
DC Central Kitchen's one-of-a-kind Healthy Corners program more than doubled the number of locations last summer from 28 stores to 67. To keep up with our growing delivery routes, we drafted an aging, unrefrigerated van into service and made do. But as summer approaches, we need your help to buy a truck that can keep produce cool and looking good despite Washington, DC's brutal heat and humidity.
The new refrigerated delivery truck we need to meet the incredible demand for fresh fruits and vegetables among DC residents in low-income neighborhoods costs $55,000. Your donation toward the purchase of a new truck will bring affordable fruits and vegetables to our neighbors who rely on Healthy Corners for access to nutritious foods.
Our Healthy Corners program launched in 2011 with the goal of bringing affordable, high-quality produce and nutritious snacks to corner stores in Washington, DC's 'food deserts.' These are parts of the city where widespread poverty and underdevelopment mean that residents have limited or no access to grocery stores, farmers' markets, or other providers of healthy food. 71% of residents of DC's food deserts are overweight or obese and 15% have diabetes.
We wanted our neighbors to have healthy choices. So Healthy Corners teamed up with small corner stores to give them the training, refrigerators, and heavily discounted wholesale deliveries of nutritious food they needed to finally sell healthy options at prices their customers could afford. And the community responded, purchasing 141,368 healthy items in 2014! A second refrigerated truck will allow us to deliver 104,000 additional items to participating corner stores in 2015.
And a new truck will allow us to do more than just keep food fresh in transit. With a second truck available, we can make smaller, twice-weekly deliveries to stores we currently visit just once a week. That means more appealing fruits and vegetables on the shelf, less waste of overripe produce, and more nourishing foods purchased.
Please donate today to help us purchase a new delivery truck and take Healthy Corners to the next level.
8 simple rules for righteous entrepreneurs
The following is adapted from a speech made at the 2015 Universities Fighting World Hunger Summit.
At DC Central Kitchen, we talk a lot about social enterprise. Usually, we use the term when we're talking about DCCK initiatives, like our Healthy School Food program, that not only bring nutritious food to our community, but simultaneously earn revenue for our organization and, most importantly, create sustainable, living wage jobs for graduates of our Culinary Job Training program. We're really proud of being a true job creator, and you've probably heard us mention that we now earn 60% of our annual budget through social enterprise.
Over the last decade, the term 'social enterprise' has been embraced by countless nonprofit, for-profit, and philanthropic groups—and that's a good thing. We should be empowering nonprofits to embrace their economic potential and encouraging businesses to be better corporate citizens. But with so many different actors using this term, it's on the verge of not meaning anything at all.
So, we have a suggestion for a new way of describing our work. Back in 1999, a Wall Street Journal reporter visited DCCK. Long before social enterprise was a ubiquitous term, here was a resourceful outfit, fighting food waste, combating hunger, giving economic opportunity to jobless adults, and smartly deploying every dollar for maximum impact. Puzzled, the reporter asked our founder, Robert Egger, just what she should call him.
"Call me a righteous entrepreneur," he responded.
All these years later, we've returned to Robert's insightful quip, and found new meaning in it. What follows are our eight rules for righteous entrepreneurs:
1) It's OK to be a little anti-social in service of your mission. The term 'social enterprise' doesn't fully embrace the competitive realities faced by organizations that are striking a balance between doing good and doing well. We think mission-driven organizations should be tough competitors so long as that competitiveness is in service of their core values. If a righteous enterprise is worth anything, its principles should be worth fighting for. At DCCK, one of our line-in-the-sand principles is that we don't believe in handing out free food unless it's paired with some form of meaningful empowerment, a means of addressing the root causes of why people are hungry to begin with. We draw that distinction a lot, even if it means challenging some popular perceptions about what it means to fight hunger or passing up funding that might compromise that core value.
2) Maintain a sense of productive impatience. Focus on something, do it well, and move on as a better version of yourself. We believe that anytime someone asks us 'What's new with DCCK?' that we should always have a meaningful answer. It's not enough to stand pat, protect your reserves, and wait for the next grant or angel donor to roll in. As Robert was famous for saying, we believe in relentless incrementalism, doing the little things a little better, a little bigger, a little bolder, and a little more beautifully each and every day.
3) Beware the folly of scale. Many start-up social enterprises are long on vision. Before they've made their first payroll, they're talking about taking their operation to new cities and new countries. But as Robert argued in a powerful REDF op-ed in 2014, meaningful scale isn't just about opening up more franchises or moving more units. It's really about scaling bigger ideas about righteous enterprises, fair wages, preventative measures, and racial equity that can change the operating environment of our programs, rather than simply building programs that work within existing constructs. That's the difference between plugging into the Matrix, and being The One who can reshape it. Too often, the cult of scale glorifies the individual social entrepreneur rather than the community or cause it's intended to serve. Because a righteous enterprise is about fulfilling a vision, not satisfying an ego, growth plans must be keenly attuned to community feedback. There's a reason that The Campus Kitchens Project's growth has been so steady and sustained. Our model of replication encourages students to carefully examine existing needs and services, and in doing so build robust community connections that can support lasting change.
4) Shoot to thrill. As Robert told that WSJ reporter in 1999, pity is incapable of creating anything of substance. One person's guilt cannot liberate another from the bondage of poverty and lack. The ideas and actions of a righteous enterprise should excite others about what's possible and capture their imaginations. And most importantly, those ideas and actions should excite the people who work for that enterprise. Come volunteer with us sometime, and ask the women and men running our kitchen how they feel about DCCK (or check out this video).
5) Be proactively responsive. A functioning operation can't be purely reactionary, but it also should never put its mission and constituents at the mercy of a rigid five year plan. For example, last year, our Evaluation Unit found that the number of DCCK culinary graduates who were finding part-time rather than full-time employment was creeping up. Instead of patiently waiting for existing employers to create more full-time opportunities, DCCK teamed up with food business incubator Union Kitchen to help create new employers who could offer those full-time jobs. We then piloted a transitional employment program that had a 100% success rate in guiding our graduates into full-time, unsubsidized employment with Union Kitchen member businesses.
6) Failure is an option, if you're failing forward. Failure is a far better teacher than success. And we believe that sharing our failures can help others build on our work and move our community forward. That's why we took three years of lessons learned through our Healthy Corners program, compiled it into an honest, practical how-to manual, and gave that manual away for free to anyone who wants it. Healthy Corners spent years on the bleeding edge of innovation, and we want other groups to replicate what's now working, avoid approaches that clearly didn't, and find ways to do an even better job at fighting food deserts.
7) Don't take %$#@ from anyone. You can't succeed if you're always afraid of someone cutting your funding or denying your next grant application if you speak your mind, or adjust a program, or embrace a new political cause. If that concern comes up a lot, you probably shouldn't be working with those partners anyway. On an individual level, don't put up with people disrespecting the people you serve or the sector you work in. When people tell us, "Oh that's so good of you to fight hunger," we tell them how smart it is, and why it's smart for them to get involved too.
8) We want to be humble about this last one, because it may not make sense for every group or every cause. But at DC Central Kitchen, we believe we have a moral obligation to put ourselves out of business or go out of business in the attempt. Our model of empowerment is designed to shorten our community's line of hungry people by the very way that we feed it—from engaging our culinary students in our daily meal production, to providing living wages, to helping 80 partner agencies across DC save $3.7 million dollars in food costs annually that they can then reinvest in their life-changing services. But beyond our model, we believe our daily business involves taking risks in service of our community and putting our money where our mission is. Instead of using our (admittedly small) year-end surplus to boost executive salaries, we provided an additional match to our employee retirement fund—because we believe women and men getting their first jobs after decades of unemployment or incarceration deserve all the help they can get in building a decent, dignified retirement.
Dig the idea of #RighteousEnterprise? Check us out on Twitter @dcck and join the conversation!
DCCK's Chow-Chow Now Available at Whole Foods!
If you didn't make it to the Capital Food Fight™ last Tuesday, or happen to read the article in The Washington Post last Wednesday, then you probably haven't heard that DCCK has made our first foray into the supermarket food manufacturing space! That's right, our Chow-Chow, a sweet, pickled relish made from a combination of vegetables and served cold, is now available on Whole Foods Market olive bars and packaged in 'to go' containers at the Tenleytown, Georgetown, Foggy Bottom, and P Street locations.
Like all of our social enterprise activities, DCCK will produce and distribute the Chow-Chow out of our Nutrition Lab kitchen facility located in Northeast DC, and each batch will be prepared by graduates of our Culinary Job Training program.
Chow-Chow can be eaten by itself or as a savory condiment on fish, poultry, crackers, and a variety of other foods. Head over to your local Whole Foods and try it for yourself – 100% percent of proceeds support DCCK!
DC Central Kitchen Appears on 'The Chew'
Yesterday, DC Central Kitchen staff, graduates, and friends grew a little bit closer to each other as we shared in the delight of seeing our very own CJT graduate Howard Thomas on ABC's hit cooking-themed daytime talk show, "The Chew."
The show dedicated a significant amount of air time to portraying the work of the Kitchen and our graduates. Howard, who is currently the lead production cook at Washington Jesuit Academy for our Healthy School Food program, did such an incredible job representing the Kitchen and sharing his story in front of a live studio audience!
Thank you Carla Hall, Mario Batali, Michael Symon, Clinton Kelly, Daphne Oz and the entire crew of "The Chew" for highlighting our work and our mission to use food as a tool to strengthen bodies, empower minds, and build communities.
Check out a short clip of yesterday's episode here!
From Campus Kitchen to Corner Store: Huan Song and DCCK Bring Good Food Where it's Needed Most
Huan Song used to dream of being a professional chef. Today, she aspires to make fresh, nutritious food available in all of DC's poorest neighborhoods. A love of cooking and her volunteer work with The Campus Kitchens Project linked these two dreams and led her to her current job as nutrition and community coordinator at DC Central Kitchen.
The Campus Kitchens Project feeds a love of cooking
Huan has been involved in nutrition and food issues since she was a teenager. She graduated from the College of William and Mary in 2013 with degrees in environmental science and business administration, but her first love was culinary arts—specifically French cuisine—and she planned to go to culinary school after high school.
"I learned French and everything," she laughs.
Her parents suggested she spend time working in a restaurant kitchen before enrolling in culinary school. This was sage advice, as it turned out: Huan hated the hectic kitchen environment, but her love of cooking remained intact.
"So I went to college. But there was no kitchen in my dorm and I needed a place to cook. My first week at college, I went to an information session on Campus Kitchens," she says.
Over one-third of all food in the United States is never eaten—it gets thrown out, usually after it has been harvested, transported, processed, and sold. This waste drives up food prices, uses up resources, and adds to pollution. At the same time, millions of people in the U.S. suffer from hunger and malnutrition. Through The Campus Kitchens Project, student volunteers at 36 schools around the country address the dual problems of waste and hunger by recovering unused food from cafeterias and preparing and delivering nutritious meals for people in need. They also teach kids and families about nutrition, develop partnerships with farms and other institutions to make efficient use of food, and build connections in their schools' communities.
Huan volunteered for The Campus Kitchens Project throughout her college years. She began gleaning for the program from a farmers' market in Colonial Williamsburg that she frequented every Saturday, getting to know the farmers and bakers, who were happy to donate their unsold products to the program.
She also joined the Botany Club, worked for food service company Aramark doing market-sustainable procurement for the campus dining service, and interned at an international development organization to learn more about food and development issues.
In the process, she developed a passion not just for food, but for food justice, and that's what brought her to DC Central Kitchen. As nutrition and community coordinator, Huan works on two DC Central Kitchen programs, Healthy Corners and the Truck Farm, that aim to bring fresh produce to food deserts (parts of the city where such food is scarce or financially out of reach) through an approach that involves and benefits stores, customers, and neighborhoods.
Access to real food in all DC neighborhoods
Cheap eats—highly processed snacks and convenience foods that are high in calories but low in nutritional value—are abundant everywhere, and for many, they offer an inexpensive way to satisfy hunger. But for too many communities, processed snacks are all that is available, because fresh, nutritious food either is not sold where people live or is too expensive for them to buy regularly.
Huan believes that affordable, nutritious food should be accessible in every neighborhood in DC, not just the affluent ones. The lack of nutritious food in low-income areas contributes to poor health and can make it hard for kids to succeed at school (and adults at work), adding to the many challenges they already face. She and her colleagues at DC Central Kitchen are working with communities and businesses to increase the availability of nutritious and affordable food in DC's food deserts.
"We want to provide people with access to nutritious food," she says.
Healthy Corners finds convenience stores in low-income neighborhoods that are located in high-traffic areas without a nearby grocery store, places where fresh produce is not available. Healthy Corners works with shop owners who are interested in participating in the program to make fruit, vegetables, and other nutritious foods and snacks available in their stores.
Normally, the cost of procuring a small amount of perishable produce would be too high for a small corner store in a low-income area, but Healthy Corners buys it in bulk for all 36 participating stores, and store owners order only what they need from DC Central Kitchen.
The program works with the store owners to look at what they sell, who their customers are, and what their customers want to buy. It then helps the stores market the products through attractive branded displays and periodic cooking demonstrations on the stores' high-traffic days.
Healthy Corners breaks down barriers
Even city residents who are lucky enough to have access to affordable vegetables and fruits may never have had a chance to see how they grow. To give them a glimpse, Truck Farm brings rows of herbs, lettuces, strawberries, and other garden vegetables to them—in the back of a pickup truck.
Since 2011, the travelling garden has been going to city events, Healthy Corners cooking demonstrations, and to schools, where kids can see how a tomato plant or a head of lettuce grows. Cooking demonstrations feature some of the vegetables that are growing in the truck, so people can see the link between a garden and a meal.
Kids play an important role in making Healthy Corners work. Through DCCK's Healthy School Food program, kids learn about the benefits of fresh food and are given a voice in how to eat it: At cooking demonstrations in schools, students sample a given ingredient—say, kale—in three different recipes. They vote on the best-tasting recipe, and that dish is later featured in the school cafeteria. Huan says that, given the chance to pick their favorite dish, the kids are often more open-minded about new foods than their parents. To make it as easy as possible to include new dishes in their families' diets, the program gives the students recipe cards and a list of nearby stores that participate in Healthy Corners where they can buy the ingredients.
The Healthy Corners model is succeeding because it aligns its goals with those of the store owners and customers. The stores want to attract customers, and one way to do that is to show they care by offering healthful food.
"The shop owners are happy to take ownership of the program and promote it, because customers like it," says Huan.
It also increases their chances of winning DC government "Great Streets" capital improvement grants to improve storefront facades or upgrade equipment. More attractive stores and happier customers are good for business and the neighborhood.
DC Central Kitchen has received a second grant from DC's Department of Small and Local Business Development to expand Healthy Corners to 30 more stores this summer. Huan hopes the program will "take down barriers"—she means both the plexiglass windows that are all too common in stores as well as the barriers to food security that low-income communities face.
She sees it as part of the larger food movement advocating healthy, sustainable food systems that benefit everyone.
"The food movement is a long process, like the women's movement and civil rights movements. We're at the beginning of that process," she says. "I want Healthy Corners to be a household name; I want fresh fruit and vegetables to be as available as Coca Cola."
DC Central Kitchen's New Year's Resolutions
2014 marks DC Central Kitchen's 25th Anniversary – and we're proud of our real results from the past year. Looking forward, 2014 promises to be an exciting year where we can expand our impact and take on unfinished business. Here are some of our New Year's Resolutions for this year:
Double Number Of Participating Healthy Corners Stores
Through new partnerships, we're undertaking an ambitious goal: doubling the number of corner stores participating in our Healthy Corners program to make affordable healthy snacks and fresh produce more available in DC's most food insecure neighborhoods.
Expand the Culinary Job Training Program
Last year, we expanded our Culinary Job Training Program to two new sites: N Street Village and Arlington County. This year, we will continue expanding our offsite programs to increase the number of students we train.
Promote Long-Term Progress of Culinary Grads
Once our graduates are employed, that's not the end of their relationship with DC Central Kitchen! We continue to cultivate our community of Culinary Graduates to ensure they have the support network in place to stay employed. This year, we've made crucial investments to strengthen that support network with the recent additions of a full-time clinical social worker and retention coordinator.
Utilize Healthier Ingredients in Agency Meals
We at DC Central Kitchen believe that everyone deserves a quality, home-cooked meal! Our agency meals are healthier and higher in quality than ever before, and we want to continue that progress by incorporating more fresh ingredients and scratch preparation into the 5,000 meals we prepare every day for 88 DC nonprofits.
Hire More Graduates!
Our social enterprises provide many employment opportunities for our Culinary Grads – and this year, we plan to hire more as we expand our School Food and Healthy Corners programs.


text:
every northwoods season at Long Lake
North, Phillips, Wisconsin
along the north shore of Long Lake in the
northern Wisconsin community of Phillips,
county seat of Price County, Long Lake North
is a luxurious resort vacation
destination. Catering to single
couples and groups of up to 16 adult guests
for year-round comfortable lodging. Come to
Long Lake North for summer or snowmobile
vacations, corporate retreats and wedding
Lake North offers two beautiful, fully-equipped
3-bedroom, 2-1/2 bath condominium units, each sleeping
up to eight adults on king and queen size beds.
Each 2,000 square foot unit has a complete kitchen, great
room, upstairs sitting room, lots of closet space and a
meetings, dinners and larger group affairs, we are happy
to arrange catering.
at Long Lake North include a large dock system, sandy
beach, swimming platform and use of various water toys.
A pontoon boat is available for rental. There is a large
picnic area with tables and two fire-ring areas, one in
the picnic area and another on the beach. Each unit has
its own charcoal grill and outdoor dining area. We even
have a large finished garage for motorcycle and
snowmobile parking or larger group dining and meetings.
There is space for trailer parking.
attractions include lakes, woods, Wisconsin's highest
point, community fairs and celebrations, public and
private hunting lands, extensive trails for skiing and
ATVing, 500 miles of the finest groomed snowmobile
trails in Wisconsin and more.
to the northwoods and visit friendly Phillips,
Wisconsin. At Long Lake North we will do everything
possible to make your stay with us relaxing, satisfying,
and enjoyable.
-Carol, Illinois
Web Design Copyright
© 2014 to Present. All rights reserved. |
Technical Assistance: firstname.lastname@example.com


text:
© iStockphoto.com
Mastering The Squat
5 Ways To Master The Squat
It is important to remember that there are several squat variations, and depending on the variation you choose to perform, the results you experience will be slightly different.
Furthermore, when you periodically change the type of squat that you do, you will see continual muscular improvements that result from the slightly different stimulus received during each movement.
Mastering the squat variations here will help you achieve your goals.
1- Power squatThe power squat primarily targets your glutes and hamstring muscles, but it also works the lower back slightly. This squat variation is a great alternative for those who are looking for a variation to the more traditional exercises, such as hamstring curls and deadlifts.
Generally, you should be able to lift a slightly heavier weight during the power squat, which makes it ideal for those who are trying to maximize leg development. If you're in this group, you will want to regularly include this exercise in your program.
The power squat requires a smaller angle between the upper body and the lower body than traditional squats. As such, you will need to lean forward and shift your weight slightly backward to really target the glutes. Also, when setting up this lift, the bar should be resting on the back, upper portion of the shoulders. The placement of your hands will be a personal choice, but most will use a narrower grip unless flexibility is an issue.
Your head should also be kept up, with the shoulders back and the chest out — this will help to keep your back straight and prevent injuries. The stance you take will also be a personal preference: Some people are able to squat really well using a narrow stance squat, while others prefer a wide stance. The most important factor is that you are able to maintain your correct balance and form, so use the stance that allows you to do this the best. Your toes should be pointed outward, at about a 45-degree angle. This will help keep the weight distributed over your base.
Once you have this starting position ready, slowly begin to squat down, until your rear is about even with your knees, and then press up to complete a single rep.
The power squat focuses on building power and you'll want to work in a rep range that is conducive to this. Perform 4 to 5 sets of about 3 to 6 reps.
2- Olympic squatThe Olympic squat focuses on putting you through a greater range of motion, which allows you to develop strength that can be better utilized in a variety of positions, not only in a select range of motion. This squat also does a good job of balancing the load placed on the quads and hamstrings, making it a more all-inclusive exercise. With the power squat, you would likely need to perform an additional movement to hit the quad muscles, whereas, with the Olympic squat, you can use it for both quads and hamstrings. Finally, this exercise is a better choice for those who have lower back pain, as there's less pressure placed on that part of the body.
When performing the Olympic squat, you should aim to dip your rear a little lower and keep your upper body more upright.
Many guys will also go slightly lower, in terms of knee bend, than with the power squat. If you have knee problems, however, it may be wise to take a more moderate approach to how low you go so that you avoid putting too much stress on this joint.
Mastering the squat is easier than you think…
The rep range depends on the goals. If you are looking for power, aim for 3 to 6 reps and if you are looking to gain muscle, aim slightly higher (about 6 to 10 reps). Again, do about 4 to 5 sets.
3- Wide-stance turned-out squatThe wide-stance turned-out squat targets the inner thigh muscle more than it does the outer quad. This squat is also great for those who are naturally more turned out in the hips, as the knee tracking feels more natural. This movement also places less stress on the lower back since you will maintain an upright position for the most part.
When performing this squat, place your legs slightly wider than shoulder width apart and angle your toes outward. The bar should rest on your shoulders and your hands in a relatively wide grip range. Keep your head up and sink into the squat position; think of pressing the knees slightly in the outward direction to ensure they move over the toes. If you find that they aren't tracking properly, that is a good indication your toes are turned out too far and you should move them slightly inward.
Squat down until you are as low as you can go, however, note that you will not be able to go as low as with an Olympic or a power squat. Once you've reached the bottom, press the weight back up once again.
This squat is less intense than others, so you'll likely want to do an additional quad movement. For this reason, use it as an accessory exercise and aim to perform 2 to 3 sets of 6 to 10 reps.
4- Front squatThe front squat is performed with the bar resting on front of the body, unlike the three previous squats described. This means that, since the weight is focused in front of the body, your quads are really going to get worked. You will also need to slightly adjust your balance to place the majority of your body weight over your toes.
This is a great exercise to perform for those who participate in sports that require you to be in the "ready" position quite often, as it has a similar balance profile and will help improve muscular endurance for those sports.
When doing a front squat, balance the bar right over your collar bone area and use either an underhand or overhand grip, depending on personal preference. Keep the weight over the front of your toes and squat down until your thighs are about parallel or slightly lower to the floor. Pause in this position for a second and then return to the start. Make sure you remember to breathe while doing this exercise.
Front squats are great for adding strength and size to your legs, so you will want to work in a rep range that encourages this. Perform 3 to 5 sets of 8 reps. Once you're comfortably able to do these 8 reps, increase the weight and decrease the reps to 5 and build up to 8.
5- Split squatThe split squat is good for those who tend to be weaker in one leg since you will be working each leg individually.
This version of the squat predominately targets the glutes, while the quads and hamstrings act as synergists. The farther out you place the leg you are working, the more you will take the pressure off the quad and place it on the hamstrings, so that is something to keep in mind depending on what muscle group you are aiming to work.
To perform the split squat, take two dumbbells (or rest a barbell across your back or shoulders) and find a bench to place your rear foot on. Keep your body weight over the front (standing) leg and bend that leg until you reach a position where your knee is at about a 90-degree angle (the guy in our video goes a bit too far in our opinion). Once you are as low as you can comfortably go, push yourself up using the glutes.
The split squat is a great exercise to add to another, more stable, squat movement and as such, perform 2 to 3 sets of 8 and 10 reps.


text:
Articles tagged with: Australia
Here is Elliot Drury's latest video kitesurfing in the pristine waters of Whitehaven Beach, Queensland. Watch this short edit shot during winter time in Australia.
Second part of the series Ocean Junkies called "Getting Addicted" The spots that Drew and Rom visited this time were Safety Bay and Augusta. It was shot from December to February 2013. It makes you …
Andy Yates, a kiteboarder from Australia with over 7 year of experience talking about his future plans and what has he been up to recently. Watch and catch up with Andy.
2012/13 kiteboarding season of a Polish rider, Przemyslaw Wojcik was spent in Sunshine Coast, Eastern Australia. This short clip shot by Glen Bowden was shot a year after Przemyslaws bad shoulder reconstruction surgery.
A short film documenting one morning in a day of a kitesurfer Florian Scharcher. It speaks about the balance that one have to make between what one have to do and what would like to.
Another talented Polish rider Katarzyna Lange ripping it in Australia 2013.
Last February Slingshot Australia showcased kitesurfing as a demonstration sport at the Surf Fest event, an ASP 6 star World Qualifying Series (WQS) held in Newcastle Australia.
This is a short clip of Malin Amle riding in Perth, Western Australia. The video was shot mostly at Safety Bay and Woodmans Point (aka Woodies).
An awesome postcard clip from the Western Coast of Australia. Markino Orru and Angela Figus spent some amazing time sightseeing and kitesurfing in Oz. Have look and get stoked to travel to Australia as we …
Kimberley Busteed introduces Canadian-born adventurer Adrian Midwood. He made his dream of kite surfing across the Pacific come true and here you can find out how it all happened.
Jon Bleiker pulbished a new video with fresh b-footage shot in point walter and safety bay, Western Australia.
Ryland Blakeney and Marty Sneeuwjagt hit the road to search of new surfing spots in the South of Australia. !


text:
Myspace wasn't cool when I was in high school. It was all about Nexopia.
Myspace wasn't cool when I was in high school. It was all about Nexopia.
Different keys…not working. No thanks.
I'm a Christian and I was not offended because this post represents atheist beliefs but because it represents them with immaturity and tactlessness. On another note, Catholics believe the Pope is chosen by God. Not all Christians believe this, nor do all religious people.
I don't care who the Pope is because he believes God chose him, but rather I care who he is because it will affect our world. Hopefully, he will be a kind person who values what Jesus stood for, such as mercy, justice, and love rather than placing judgement on those who truly need to be shown acceptance.


text:
|Page: 2 of 5
|Sort By:
Vacation Rentals , Peru - Condo: 3 Bedroom, 3 Bathroom, Sleeps 6. Location: Miraflores, Lima, Peru (Malecon Cisneros) Features: Full Kitchen ,High-Speed internet, Telephone, Cellphone, Cable tv, Garage, Maid Service Avail...
Vacation Rentals , Peru - House: 4 Bedroom, 4Bathroom, Sleeps 5.. Location: Punta Negra, Lima, Peru Features: Cooking Utensils Provided, Full Kitchen, Parking, Gas Grill, High-Speed Internet, Maid Service Available, and Terrace. Description: Cozy house with "Ocean View"
Vacation Rentals Lima, Peru - Two beautifull apartment with Ocean View. Condo: 4 Bedroom, 3 Bathroom, Sleeps 6. Location: Miraflores, Lima, Peru Features: Furnished, Cable, Internet, Washer, Dryer, Phone, Pool. Descriptio...
Vacation Rentals , Peru - Beautiful and modern 1 bedroom apartment (60 sqm) located in the center of Miraflores, in the elegant Pardo Avenue. Furnished, cable, internet, gym/fitness center, towels and sheets.
Vacation Rentals , Peru - Still looking for APEC 2008 lodging? We are a very good option for you: Beautiful apartments for rent, fully furnished, services included, exclusively for visitors. Located in Miraflores, the best touristic district of Lima. We have the best price!
Vacation Rentals , Peru - Condo: 3 Bedroom, 2 Bathroom, Sleeps 6. Location: Miraflores, Lima, Peru Features: Onsite amenities include swimming pool with sea view, sauna, Gym, Jacuzzi, children play area, pool, Ping-Pong Table, home theatre room, 24 hour security, lobby
Vacation Rentals Miraflores, Peru - Our apartment is located within a stone's throw of all the amenities in Miraflores, including fashionable restaurants, excellent for you to EXPLORE !!! since it places you near everywhere you want to ...
Vacation Rentals Miraflores, Peru - Stunning condo with 1,200 sq.ft. is perfectly located in downtown of Miraflores,fully furnished, this home is turn key ready- just bring your suitcases. Balcony with a beautiful view, walking distance to everything, restaurants, banks,etc.
Vacation Rentals Miraflores, Lima, Peru - Brand new, ultra-luxury condo in Av. Larco in the true heart of Miraflores. Designer furniture + state of the art entertainment. Most convenient location: all amenities, shopping, restaurants, banks, ...
Vacation Rentals Miraflores, Peru - New duplex 2 bedroom, 2.5 bathroom apartment just close to Miraflores Coastline. The building is on a quiet back street with a 24-hour doorman. The best location and the pleasure to being in Miraflore...
|Page: 1 | 2 | 3 | 4 | 5 |
Find a vacation rental home in Peru for your vacation. Stay at one of our rustic cabins, cozy cottages, or authentic condos in Peru. We have everything from large rental homes to small villas. Rent for a weekend, week, month, or entire season! Vacation rentals are great accommodations for families and large groups. Enjoy the convenience of a full kitchen and save money by eating in. Living like the locals at a vacation rental assures you an authentic travel experience. Browse our vacation rentals in Peru and plan your vacation today!
|Page: 1 | 2 | 3 | 4 | 5 |


text:
A few moments from the first few days of the Windrider Forum in Park City, UT. Windrider Forum Park City takes place during the Sundance Film Festival. This video features clips from Will Stoller-Lee, Fuller Seminary, Colorado; Craig Detweiler, Brem Center, Fuller Seminary, Pasadena, CA; and director/writers Justin Lerner, Anna McGrath and John Arlotto. (Arlotto and McGrath were shot outside the Eccles Center - one of the premier movie venues during the Sunday Film Festival.)
Camera: Jason Smart, Director: Bill Kinnon, Producer: Imbi Medri
Loading more stuff…
Hmm…it looks like things are taking a while to load. Try again?


text:
Good Omens
The Nice and Accurate Prophecies of Agnes Nutter, Witch
From Library Staff
The time of the antichrist is at hand, but a mix-up at the hospital leaves the child of Satan to be raised in a quiet middle-class British family. Meanwhile, agents for heaven and hell, who rather like living on Earth, cooperate to prevent the apocalypse. If you like wry British humor with a das... Read More »
From two delightful imaginations comes a comic masterpiece in which the Four Horsemen of the Apocalypse ride motorcycles, the hound of the devil chases sticks, and the end of the world is subject to Murphy's Law.
(Heather's fave)
According to the Nice and Accurate Prophecies of Agnes Nutter -the world's only _totally reliable_ guide to the future - the world will end on a Saturday. Next Saturday, in fact. Just after tea.
Two greats, Gaiman and Pratchett, came together to write this tale of a demon and an angel who decide that their bosses' planned apocalypse does not suit them. Library Journal called it "an untrammeled romp through the latter days."
Nutter's the name, prophecy's the game. End of days, wot? Got your Anti-Christ? Check. Hell hound? Check. Satanic nun? Present! Not to mention angels both virtuous and fallen. A side-splitting novel in which being evil means never having to pay for bodywork for your Bentley and listening to lots ... Read More »
From the critics
Community Activity
CommentAdd a Comment
A comedy of apocalyptic proportions. Gaiman and Pratchett make for the perfect pairing in this dementedly entertaining, devilishly irreverent tale of angels and demons who aren't ready for the world to end...just yet. For fans of dark fantasy with a twist of wicked wit. Read Alikes: Adams' 'Hitchhiker's' series and the novels of Kurt Vonnegut.
I leant my copy and of course it never came back. So now when I feel like revisiting I'm 23rd on the library hold list (sigh)
Amazing book. It's funny and well paced, keeping everything going without being too fast or slow. The characters are hilarious and fantastic. The plot seems ridiculous but it's written so well that it isn't. One of my top ten favorite books ever.
This is hands down one of my favorite books. It's satirical and hilarious, and written by two of the best names in fantasy fiction. I wasn't able to put it down the first time I read it, and I frequently find myself wanting to reread it. It's great for a laugh, especially if you're a fan of dry humor.
The End of Days as done by Monty Python.
Satire and religion DO mix, as Terry Pratchett proves in the slightly absurd and spritely dialogue in Good Omens. Followers of the One True Faith beware, Terry's got your number.
Love Pratchett. Love Gaiman. Them working together is ineffably good.
This is close enough to being the best book ever (it isn't, but it's very close) to be worth a read.
This book is hilarious! It was a very a very interesting take on the world. I loved it!
I had not read this in about 15 years, so I was prepared to find that reality would not live up to my memories. Luckily for me, this book held up wonderfully. It's funny, thoughtful, and inventive. I should probably not wait another 15 years to read it again.
I heard it was a comedy before I read it, and was completely blindsided by the philosophical side of this novel: it really thinks about things, and it's a very enjoyable read. I'm not saying it's not funny, because it IS very funny. I'm just saying that it's not the whole of the novel.
The characters are very believable and interesting, especially Aziraphale, Crowley and Adam.
In short, I cannot recommend this highly enough. Not heavy on characters or prose, but worth reading more then once to fully appreciate the intricacy.
AgeAdd Age Suitability
terminallyCapricious thinks this title is suitable for 13 years and over
SummaryAdd a Summary
well written, very funny, the authors show that they can work together and produce a work of genius. one of the funniest books i have ever read.
NoticesAdd a Notice
There are no notices for this title yet.
QuotesAdd a Quote
There are no quotes for this title yet.


text:
- Shopping Bag ( 0 items )
School Library Journal
Update your home with new windows and doors and save energy, too. Marshall, carpenter and author, addresses the importance of lighting, ventilation, and security for the home. A gallery of inspirational photos is followed by a discussion of materials-styles and selection of windows or doors and related hardware. Included is consideration for use by those with limited mobility or strength. Planning, layout, and installation are covered next. Good, logical, step-by-step instructions walk the reader through simple to more complex projects, but basic techniques are tucked in the back appendix. Excellent coverage of the topic. Recommended.
—Karen Ellis Copyright 2007 Reed Business Information


text:
Originally written on Pro Sports Daily | Last updated 11/15/14
For all that's been made of how Jordan Schafer fits into the Astros' new patience profile of higher walk and strikeout totals, there's another element of the game that he adds to a team with little. In replacing Michael Bourn, whom he was traded for, Schafer provides one of the few significant base-stealing threats on the roster. Through the Astros' 1-0 victory Friday, Schafer maintains a pace for 56 steals and 20 times caught, putting him roughly at the threshold of success that must be maintained to make it a worthwhile endeavor at all. His career numbers of 35 steals and nine times caught are far greater than his ratio of 87:50 in the minors, when he was really struggling with the art despite great speed. "I never felt comfortable stealing bases (in the minors)," Schafer said. "I still have some stuff I need to work on, but I feel very comfortable doing it now." Schafer gives plenty of credit for those who have helped him go from just a speedster to a true...
Comments are closed.
What do you think?To leave a comment, you can:
MLB News
Delivered to your inbox
You'll also receive Yardbarker's daily Top 10, featuring the best sports stories from around the web. Customize your newsletter to get articles on your favorite sports and teams. And the best part? It's free!
Follow us on Twitter
|Best of Yardbarker
|NFL News
|MLB News
Today's Best Stuff
For Bloggers
Join the Yardbarker Network for more promotion, traffic, and money.
Company Info
What is Yardbarker?
Yardbarker is the largest network of sports blogs and pro athlete blogs on the web. This site is the hub of the Yardbarker Network, where our editors and algorithms curate the best sports content from our network and beyond.
|© 2015 Yardbarker, Inc. All rights reserved. Use of this website (including any and all parts and components) constitutes your acceptance of these Terms of Use and Privacy Policy. (What's New?)


text:
Trying to find a top specialist to assess potentially troubling findings on a routine mammogram? That nerve-wracking process may soon get easier.
Federal officials announced Monday that Medicare will finally allow the use of its extensive claims database to rate doctors, hospitals and other medical service providers.
The report cards could be produced by employers, consumer groups or others, and would have to follow valid statistical methods. Individual medical providers would have 60 days to privately challenge a report before its release.
But Medicare acting administrator Marilyn Tavenner calls it "a giant step forward" to making medical decisions less daunting for patients while holding providers accountable for quality.
Consumer groups that have long pushed for the release of the data said they are still poring over the fine print.
More breaking news
- Certified Labs relocating to Melville
- FINRA fines Oppenheimer $3.75M in employee fraud case
- Authorities go after crooked car deals in national crackdown
- Developer dispute could stall Coliseum project
- Fresenius takes over Good Sam dialysis centers
- As Supreme Court weighs healthcare, NY exchange likely safe
- Summit: LI needs to retain and attract talent
- Fewer Americans filed for unemployment benefits last week
- Romney stands by his plan, attacks Obama's
- Romney calls tech transfer key in attracting VC to LI


text:
City of Angels: Tony Award-Winning Film Noir Musical
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for City of Angels was Thursday July 11, 2013 / 7:30pm.
Currently at Theatre Three
Hot Mikado Gives Gilbert & Sullivan's Comic Opera a Jazzy '30s Update
- Full Price:
- $20.00 - $50.00
- Our Price:
- $10.00 - $25.00
Gilbert & Sullivan get bitten by the jitterbug in this swingin' 1930's-style update of The Mikado at… More
Venue Details
Reviews & Ratings
Featured review from Danyelle Stone
view more less of this review
This was a good show and it was entertaining - but we sat on the back row next to the band so it was really hard to hear what the performers were saying.
About the Ticket Supplier: Theatre Three
Theatre Three produces seven mainstage productions each year in addition to special children's performances, off-site educational outreach, special event productions and the programming in Theatre Too (the basement performing space). Theatre Too was, from September of 2000 until July 2003 home to the longest-running show in the history of Dallas theatre, the musical revue I Love You, You're Perfect, Now Change!


text:
I'm so excited about this post. I cover everything from hair to makeup (sneak peek: your makeup should be an extension of your skin care, according to Hayley, Paleo Super-Friend and Primal-Palate gourmet/esthetician).
-Princess Poo
-Shine + (protein-free conditioner)
-Glissade (perfect for curls)
-Shower Butta (incredible moisturizers)
-Custom Perfume Sprays (These are ridiculous. RI-DIC-U-LOUS.)


text:
Fair Use, Free Use, and Use by Permission
How to Handle Copyrights in All Media
Who needs this book? Only every writer, photographer, illustrator, designer, businessperson, musician, songwriter, filmmaker, teacher, researcher, advertiser, and Web designer in the United States. How to find copyright owners, request permissions, and keep records? Easy-reference copyright duration chart, form agreements, form letters, resources, and checklists; Permissions--they're enough to make anyone crazy. Thank heavens there's Fair Use, Free Use and Use by Permission, the one-volume reference that is sure to save the sanity of thousands of grateful readers. Writers, photographers, illustrators, designers, teachers, researchers--anyone involved with intellectual property needs this practical, straightforward guide to copyright law. Find out what constitutes fair use, how to get permissions, and how to protect creative work, plus learn about copyright infringement, public domain, and much more. Illuminating true-life stories enliven the ins and outs of copyright law, and helpful charts, resource lists, and forms make the permissions experience vastly more manageable. Let a respected intellectual property lawyer show the way through the copyright maze!
Publisher: New York : Allworth Press, c2005
Branch Call Number: 346.0482 W7492f 2005
Characteristics: viii, 247 p. :,forms ;,23 cm
From the critics
Community Activity
CommentAdd a Comment
There are no comments for this title yet.
AgeAdd Age Suitability
There are no ages for this title yet.
SummaryAdd a Summary
There are no summaries for this title yet.
NoticesAdd a Notice
There are no notices for this title yet.
QuotesAdd a Quote
There are no quotes for this title yet.


text:
Drop (6)
Fashion Studs (3)
Hoop (2)
Solitaire Studs (1)
Diamond (11)
Morganite (1)
Princess (1)
Round (11)
Gold (11)
Sterling Silver (1)
Rose (1)
Two-Tone (2)
White (9)
Learn more about:
We want to hear from you! Customer Feedback Form
Receive a $50 Offer When You Sign Up for Email*
No Thank You
*Valid for new registrations only.
A welcome email will be sent with your offer information.
Privacy Policy


text:
K Street
Net neutrality: A lobbying bonanza
The debate over to how to protect an open Internet has been a prime opportunity for K Street.
Scott Walker goes to K St.
He's promoting the 527 group he recently created.
Out of Abramoff's ashes
His scandal-tarred law firm rises again as a powerhouse.
Nearly 300 K Streeters flock to meet Scalise
The embattled House Republican introduced them to his political operation.
K Street Republicans hope for uptick
Lobbyists and consultants strategize about a Republican-controlled Senate.
'Power broker' Thomas Boggs dies
The lobbyist was long known on K Street as having an unparalleled reputation.
K Street kicks into gear for GOP
Senate Republicans rally the troops and K Street as their chances for the majority are within reach.
Billionaires who bailed out K St.
Casino magnate Sheldon Adelson and activist William Ackman are spending big on policy fights.
K Street's Russian bonanza
Companies all over the world are scrambling to hire lobbying firms to protest business interests.
K Street gets peek at House agenda
The lobbyists were briefed the same day Republican lawmakers got a memo from Rep. Kevin McCarthy.
K Street market dims for Dems
The boom years are over for lobbyists, and they don't seem to be coming back.
Akin Gump now largest lobbying firm
The group overtakes struggling Squire Patton Boggs in quarterly revenues.
Lott, Breaux plot Squire Patton Boggs comeback
Squire Patton Boggs is counting on Trent Lott and John Breaux to pull off a third act.
Amazon hires drone program lobbyist
Amazon Prime Air brings on a major K Street firm to make the case for commercial drones.
Exodus hits Patton Boggs
After the merger with legal giant Squire Sanders was finalized, moving trucks lined up out front.
Patton Boggs merger creates giant
The combined firm will have about 1,600 lawyers spread across 45 offices in 21 countries.
K Street goes back to school
Two new programs will let aspiring downtowners and K Street veterans alike learn new skills.
Mass departure at Williams & Jensen
Five lobbyists leave to start a new full-service government relations shop.
Lobbyists kick in for Ready for Hillary
Nearly 20 consultants and lobbyists are co-hosting a Ready for Hillary PAC fundraiser.
Who says lobbyists can't win?
David Jolly's victory is the latest sign that a D.C. lobbying background isn't a deal-breaker.


text:
The largest ever single FEMA grant will repair and fortify 33 NYCHA developments.
Vanessa Fontaine will join Sen. Charles Schumer at the speech in support of Avonte's Law.
The president is expected to make the announcement Saturday at the White House.
Police and the Manhattan DA's office have begun arresting and prosecuting bodega workers selling K2.
The mayor could boost his stature nationally if the 2016 DNC comes to Barclays Center.
Schumer was in the Rockaways to discuss a relief bill for flood insurance.
St. John's Bread and Life already serves about 40,000 people a month.
Laurie Cumbo invited a diverse crowd to her swearing-in celebration for her 35th District seat.
Robert Cornegy was sworn in as the new councilman in Bed-Stuy and Crown Heights.
The Metropolitan Waterfront Alliance is starting a grassroots movement to bring a ferry stop to Astoria.
The Statue of Liberty is slated to reopen by July 4, but no date has been set for Ellis Island.
Former MTA Chair Joseph Lhota, Police Chief Ray Kelly and Mayor David Dinkins attended the event.
A new database will store information on every cell phone allowing users to make them useless if stolen.
Lawmakers want regulators to use a letter grade system for buses, the way they do for restaurants.
An advisory panel believes there is a clear connection between cancer and 9/11 toxins.
Coming Soon
Get our daily Afternoon News Update
Terms of Use |Privacy Policy
Thank you for signing up!
Would you like to sign up for additional newsletters?
Thank you for signing up for additional newsletters.


text:
MILWAUKEE (AP) — Hunting dogs are on display at two canine gatherings this week. One is in New York at the famed Westminster Kennel Club show, where judges look for perfection in the breeds' appearance — the shape of an ear, the size of a tail.
The other is in Milwaukee, where bird hunters will celebrate the canines that point out, scare up and retrieve fowl, while attending sessions on topics like training dogs to retrieve antlers.
Seventy to 100 dogs representing about 40 breeds are expected at Friday's parade that kicks off the National Pheasant Fest & Quail Classic, a trade show geared toward hunters whose prey includes quail, pheasant, grouse, woodcock and prairie chicken. The event could not be more different than the one in New York, except for one thing: Both groups have a fanatical love for their dogs.
While hair dryers, clippers and combs abound at Westminster, there will be little primping going on in Milwaukee. At most, the dogs will get baths, their nails clipped and their ears cleaned.
"The dogs that are in the show competitions are bred both for their abilities in the ring and in the field, while the dogs in the bird dog parade are just that, bird dogs," said Rehan Nana, a spokesman for St. Paul, Minn.-based Pheasants Forever and Quail Forever. "And the parade may be their only time in the show spotlight."
Only Westminster has more sporting-breed dogs participate than Pheasant Fest, Nana said.
Entrance in the parade is free, and 70 to 100 dogs are expected to take part. In contrast, it costs $100 to show at Westminster, with a limit of 3,000 dogs (this year, 2,845 will take part).
Typically parade organizers limit the parade to four or five dogs representing each breed, with fewer of rare breeds like Deutsch-drahthaars and L'epagneul Bretons. More common hunting breeds include different types of retrievers, pointers and setters.
All draw oohs and aahs from the 1,000 or so people assembled to watch and listen to the history and characteristics of each breed.
"It's just so much fun to have a chance to kind of stretch your stuff in front of the crowd that really appreciates these dogs," said Joe Strang, a pheasant hunter from Cascade, Iowa, who walked with his dog in all seven previous parades.
Continue reading this story on the...


text:
Exclusive £60 Off Bookings When You Spend £750Get Voucher Code
- ⏰ Ends: 01/04/2015
- Exclusive
- ✓ Terms & Conditions
Booking your Summer getaway early is the key to getting a bargain price. Wherever you choose to visit, you can use this voucher code to save money.
Terms & Conditions
Save an extra £60 on selected April departures with MyVoucherCodes: The £60 saving is a per booking discount code that is valid on package holidays departing between 12th April – 30th April 2015. A minimum spend of £750 per booking applies. The offer is valid from 31th March 2015 until 1st April 2015 and is only available on firstchoice.co.uk and not in any shop or call centre. The offer does not apply to hotel only, flight only, cruise or ski bookings. This offer can only be redeemed once per booking. Enter the code (50337) on to the holiday payment page on our website when making your booking. Normal booking terms and conditions apply. The code is applicable on the total price excluding insurance, if added. Offer is subject to availability and may change or be withdrawn without notice. This promotional code is non-transferable. Not valid in conjunction with any other discount code.


text:
The College, Career, and Technical Education (CCTE, formerly ROP) Department prepares students to successfully transition from secondary education to college and career. Our courses prove cutting-edge skills that enable students to succeed in post-secondary education and the workplace in the changing global economy.
Here is a list of all department members and the courses they teach:


text:
An antibody fragment able to bind to a target site is prolonged by an additional peptide. The Therapeutic agent is bound to this peptide or means are provided to bring about such binding. The antibody fragment and possibly also the therapeutic agent are included in a product so that binding to the target site delivers the therapeutic agent to the vicinity. The product may for example be for dental care, such as a toothpaste or mouthwash and the antibody fragment may then bind to a component of dental plaque.
1. A product for treating a human body target site, which site is located in the human mouth and is accessible by topical application, with a therapeutic agent, said product being selected from the group consisting of mouthwash, toothpaste, and lozenge, said product comprising:
(a) a therapeutic agent;
(b) a first antibody formed from at least one peptide chain and which is able to bind to the target site through antibody-antigen binding, said first antibody fragment having a first additional peptide other than a fragment of the same antibody, appended thereto through a covalent peptide bond; and
(c) a second antibody fragment able to bind through antibody-antigen binding to said first additional peptide and to bind the therapeutic agent to said first additional peptide, whereby in use of the product binding of the first antibody fragment to the target site holds the therapeutic agent on the target site, for the therapeutic agent to act on the target site.
2. A product according to claim 1 which further comprises a third antibody fragment which is able to bind to the therapeutic agent through antibody-antigen binding and which has a second additional peptide appended to it through a covalent peptide bond, said second antibody fragment having two binding sites and being able to bind through antibody-antigen binding at one said binding site to said second additional peptide appended to said third antibody fragment and through antibody-antigen binding at the other of said two binding sites to said first additional peptide appended to said first antibody fragment.
3. A product according to claim 1 wherein the therapeutic agent is an enzyme.
4. A product according to claim 3 wherein the enzyme is an oxidase.
5. A product according to claim 1 wherein the first antibody fragment able to bind to the target site is a fragment of an antibody to an antigenic component of the bacteria in dental plaque.
6. A product according to claim 1 wherein the first antibody fragment able to bind to the target site is a fragment of an antibody to an organism selected from the group consisting of S. mutans, S. sanguis, A. viscosus and A. naeslundii.
7. A method of delivering a therapeutic agent to a target site comprising applying a product according to claim 1 to the locality of the target site.
8. A method of delivering a therapeutic agent to a human body target site which site is located in the human mouth and is accessible by topical application which method comprises applying a product comprising
(a) a therapeutic agent;
(b) a first antibody fragment formed from at least one peptide chain and having a first additional peptide other than a fragment of the same antibody appended thereto by a covalent peptide bond so that the peptide chain of the antibody fragment is prolonged and terminated by said first additional peptide, and
(c) a second antibody fragment able to bind through antibody-antigen binding to said first additional peptide, said second antibody fragment serving to link the therapeutic agent to said first additional peptide whereby the binding of the first antibody fragment to the target site holds the therapeutic agent on the target site, for the therapeutic agent to act on the target site.
9. A product for treating a human body target site, which site is located in the human mouth and is accessible by topical application, with a therapeutic agent, the product being selected from the group consisting of mouthwash, toothpaste, and lozenge, said product comprising:
(a) a therapeutic agent:
(b) a first antibody fragment formed from at least one peptide chain and which is able to bind to the target site, said antibody having at least a first additional peptide other than a fragment of the same antibody appended thereto through a covalent peptide bond so that the peptide chain of said first antibody fragment is prolonged and terminated by said first additional peptide, and
(c) a second antibody fragment able to bind to said additional peptide and to said therapeutic agent.
10. A product according to claim 14 wherein said first additional peptide comprises a plurality of repeats of a shorter peptide.
This is a continuation application of Ser. No. 08/022,781, filed Feb. 23, 1993, now abandoned, which is a continuation of Ser. No. 07/771,670, filed Oct. 4, 1991, now abandoned.
This invention relates to the delivery of therapeutic agents to target sites, with provision for binding to the target sites.
The use of an antibody/antigen binding as a means to attach a therapeutic agent to a target site has already been proposed, for example with glucose oxidase as the therapeutic agent. This enzyme catalyses the oxidation of glucose to gluconic acid by molecular oxygen, producing hydrogen peroxide in the process. Hydrogen peroxide is rapidly decomposed in vivo, but if it can be brought close to target cells it does exhibit toxicity to those cells.
As an example of such a proposal, using whole antibodies, Knowles et al J. Clinical Investigation 52 1443 (1973) have described the use of glucose oxidase chemically conjugated to antibodies capable of binding to target cells, thereby targeting the cell killing activity against those cells which it is desired to eliminate selectively. Cell killing, however, was only achieved if other (non-targeted) enzymes were present in the surrounding medium to generate even more toxic species.
WO 89/11866 (Rama Biolink) discloses antibiotic conjugated to anti S. mutans antibodies obtained by immunisation of hens.
The use of fragments of antibodies, rather than whole antibodies, to effect immunological binding, has been proposed in various documents including EP-A-175560 and EP-A-315364 which mention chemical conjugation to antibody fragments.
Techniques for expressing variable domains in bacteria, and hence producing Fv fragments of antibodies, are described by Saikl et al Science, 230 1350 (1985) and by Oranei et al Procnatl Acad Sci U.S.A. 88 3833 (1989). Production of antibody fragments is also discussed in EP-A-368684 (M.R.C.). This mentions the possibility of producing antibody fragment joined through a linking peptide to a protein having a required function, so that the peptide chain of the antibody fragment, the linking peptide and the functional protein are all expressed as a single fusion protein. Producing such a single protein has the difficulty that the yield of expressed protein may be low.
Expression of antibody fragments with the peptide chain prolonged and terminated by an additional peptide, to act as a linker, is described in our WO 91/08492 published 13 Jun. 1991.
Broadly the present invention makes use of an antibody fragment for binding to a target site, and provides for a therapeutic agent to be connected onto the antibody fragment through an additional peptide appended to the antibody fragment, thereby to attach the agent to the target site.
One aspect of the present invention provides a product comprising one or more vehicles which contain, in the same vehicle or distributed among separate vehicles, an antibody fragment which is able to bind to a target site and which has an additional peptide appended to it, and means for binding a therapeutic agent to the additional peptide.
The product may contain the therapeutic agent although not necessarily in the same vehicle as the antibody fragment.
The invention also includes a method of delivering a therapeutic agent to a target site comprising exposing the target site to a said antibody fragment with an additional peptide appended and means for binding a therapeutic agent to the additional peptide.
In a further aspect the invention provides the use of a said antibody fragment with an additional peptide appended, to prepare a product for topical application in order to attach a therapeutic agent to a target site.
The antibody fragment is, as mentioned, able to bind to a target site through antibody-antigen binding. The additional peptide, being present for another purpose, will in general not contribute to these binding properties of the antibody fragment.
Attachment of the additional protein to the antibody fragment is through a peptide bond to an end of the antibody fragment peptide chain. In consequence this peptide chain of the antibody fragment is prolonged by the peptide which then forms a terminal portion of the resulting composite protein. One terminal amino acid of the protein will be an amino acid of the antibody fragment. The other will be an amino acid of the additional peptide.
The antibody fragment may be an Fv fragment of an antibody to the desired target. Such a fragment contains only the variable domains of light and heavy chains of an antibody. The fragment could possibly be an F(ab)2 fragment which would provide two combining sites. It might alternatively be as little as a single variable domain of one peptide chain of an antibody.
Production of an antibody fragment which has an additional peptide chain appended to it can be by expression in bacteria. Bacteria can be made to express a variable domain with an extra peptide chain already attached to the C terminus of the domain: all that is necessary is to synthesise the appropriate short nucleic acid sequence and add this to the nucleic acid which codes for the variable domain. This can be done by standard techniques.
The production of antibody fragments with attached peptide is described in detail in our WO 91/08492 referred to above.
The additional peptide is valuable as a "handle" for the attachment of the therapeutic agent. Direct attachment to the antibody fragment runs the risk that the attached therapeutic agent hinders or blocks the antigen-antibody binding function. Attachment to the additional peptide reduces the likelihood of this. Attachment to the additional peptide will generally be to a part of the peptide between the antibody fragment and the terminus of the chain.
Means for binding a therapeutic agent may simply be covalent bonding between the additional peptide and the therapeutic agent.
Conjugation of molecules by chemical reactions which join them through covalent bonds is well known, and standard methods are available. WO 91/08492 referred to above describes covalent bonding to an additional peptide appended to an antibody fragment. As is recommended in that disclosure, the additional peptide may be designed to facilitate the attachment of other molecules through covalent bonding. In particular the additional peptide may include a lysine residue for the purpose.
When the therapeutic agent is bound through chemical bonds, the product will contain the antibody fragment with the additional peptide, and also the therapeutic agent bound to the additional peptide.
In another form of this invention the means for binding the therapeutic agent to the first mentioned antibody fragment comprises at least one additional antibody fragment. One possibility here is for the therapeutic agent to be covalently conjugated to a second antibody fragment which is able to bind by antibody antigen binding to the first mentioned antibody fragment.
An alternative, preferred possibility is that there is a second antibody fragment able to bind to the therapeutic agent by antibody-antigen binding, and there are means to couple the two antibody fragments to each other. Such means could be a F(ab)2 fragment (bivalent) able to bind to the two antibody fragments, especially to antigenic peptides appended to the first and second antibody fragments.
This preferred possibility has the advantage that the entire connection between the therapeutic agent and the target site can assemble itself together, which can avoid subjecting delicate materials to chemical reactions required to form covalent bonds.
In a significant development, which is a further possibility within this invention, two co-operating therapeutic agents are utilised and there are means to bind both of these to aforesaid antibody fragments able to bind to the target site. This can then lead to both of the therapeutic agents being held in proximity to each other--promoting their co-operation--and to the target site, while avoiding steric hindrance and interference from relatively bulky whole antibodies which might otherwise do the same job. This encourages spontaneous self-assembly of the whole complex in its optimum configuration.
Preferably, means for attaching each therapeutic agent to the first aforementioned antibody fragment comprises at least one additional antibody fragment. Particularly preferred is that there are respective antibody fragments able to bind to each of the therapeutic agents, and means to couple these antibody fragments to the first mentioned antibody fragment which binds to the target site.
The invention could be used to deliver to a variety of different target sites.
The invention may in particular be used for delivery to target sites which are accessible by topical application, as contrasted with requiring the antibody fragment and any other materials to enter the blood stream. Thus, the invention may be used for delivery to target sites which are accessible by topical application to the body surface, target sites in the mouth, and target sites in material temporarily removed from the body.
One significant application is delivery of cytotoxic agents to species of the supragingival oral microflora. The oral microflora is a complex ecosystem which contains a wide variety of microbial species. One of these species may be selected as the target site. However, the likely effect of targeting to one species will be to attack both that species and other species which occur in close proximity to it. Thus, by delivering to one species which occurs in dental plaque, cytotoxic agents will be delivered to the plaque and will be likely to act against all the species which occur together in the plaque, including those responsible for plaque formation.
Extra-cellular dextran produced by such organisms could itself be used as the target site in which case the first antibody fragment is a fragment of an antibody to dextran.
One possible target species is Streptococcus mutans. This has been identified as an important contributor to dental plaque, and has been shown to be capable of inducing clinical caries lesions in germ-free animals when established as a mono-infection. S. mutans has the ability to utilise dietary carbohydrate for the synthesis of an insoluble polysaccharide matrix, facilitating attachment to, and colonisation of, hard surfaces, as well as production of acids capable of the dissolution of enamel. These characteristics have been identified as important virulence determinants. Although other species and genera have also proved capable of both acid and plaque production, or even of caries initiation in the germ-free animal, S. mutans is widely recognised as at least one significant cause of tooth decay because of the scale of its acid and polysaccharide production.
Other species which may be selected as the target species are S. sanguis, A. viscosus and A. naeslundii. These are all present in dental plaque as a substantial proportion of the species normally found in dental plaque. Because of frequent occurrence these three may be preferred target species.
As will be apparent, it is envisaged that the first antibody fragment may be suitable to bind to an antigenic component of dental plaque. In a particularly envisaged application of this invention, the first antibody fragment is a fragment of an antibody to S. mutans, S. sanguis, A. viscosus or A. naeslundii and the therapeutic agent is the enzyme glucose oxidase.
Another application is to attack species of the subgingival microflora responsible for periodontal disease. The target species could well be Bacterioides gingivalis.
For these oral applications (dental care) it would be appropriate for the vehicle(s) in the product to be suitable for topical application in the mouth.
Another possible application is to deliver therapeutic agents to attack human rumour cells, notably in bone marrow which has been removed temporarily from the body of a patient undergoing radiotherapy.
For all applications the therapeutic agent will be formed separately from the antibody with appended peptide. Various materials are contemplated as the therapeutic agents which may be delivered in accordance with this invention. One important possibility is an enzyme able to generate a cytotoxic product: glucose oxidase has been mentioned above. Galactose oxidase is another. If the target site is in the mouth, the substrate for this enzyme could be the galactose which occurs naturally in yoghurt. Further possibilities are xanthine oxidase which produces superoxide and NADP oxidase which also does so.
Other enzymes which might be delivered to a target site are lysozyme, to attack the cell wall of a gram negative bacterium or proteases to attack extracellular enzymes such as those which help to form dental plaque.
Another category of materials which could be delivered by means of the invention are enzyme inhibitors, which could act to inhibit extracellular enzymes of a target organism.
Further possibilities are oxygen generators or acid producers which could act to modify the environment in the vicinity of a target site. A particular possibility arises if the target site is in the periodontal pocket. Generating oxygen or reducing pH in this cavity would give conditions less favourable for the anaerobic organisms which can invade this pocket.
Yet another possibility is to deliver a material able to remove a limiting nutrient. More specifically, aerobactin, enterochelin or porphyrin could be delivered to a target in the periodontal pocket. They would complex with iron and reduce the concentration of iron available to bacterial invaders of this pocket. These materials could be used in their simplest state as the therapeutic agent. However, they could be used in glycosylated form in which the glyosyl chains would be antigenic, allowing the possibility of binding by an appropriate antibody. Alternatively they could be covalently bound to some other moiety to which an antibody fragment could attach.
Another possible type of therapeutic agent is a non-enzymic catalyst. This could be a transition metal attached to ligand(s). For instance Borggaard, Farver and Andersen, Acta Chem. Scand. 25 [1971] 3541 have shown that iron with ethylene diamine tetraacetic acid (EDTA) as ligand will catalyse the conversion of hydrogen peroxide to hydroxyl ion and an OH free radical which would be very short lived but also very toxic.
When there is more than one therapeutic agent it is particularly envisaged that these will be enzymes able to co-operate with each other. Of special interest is the combination of an oxidase such as glucose or galactose oxidase and a peroxidase such as horseradish peroxidase which uses peroxide to convert halide ions to oxidised halide species that are even more toxic than peroxide. A peroxidase may also use peroxide to convert thiocyanate to hypothiocyanate. It is also possible that a therapeutic agent will comprise two enzymes attached to a common intermediary. This may be a synthetic polymer having chemical functionality to enable the attachment of enzymes by chemical reaction. A suitable polymer is polyethyleneimine which is a branched polymer with amino groups at the ends of the branches.
Glucose oxidase and horseradish peroxidase are both enzymes with pendant glycosyl chains. Such enzymes can be covalently bound to polyethyleneimine by first oxidising the enzymes in aqueous solution with periodate to generate aldehyde groups in the pendant glycosyl chains. These groups will then form Schiff bases with amino groups on the polyethyleneimine, at alkaline pH (e.g. pH 9.5) after which reduction with borohydride can be used to reduce any unreacted aldehyde groups and also the Schiff bases. The latter increases stability of the link between enzyme and polymer.
The antibody fragments(s) and possibly the therapeutic agent(s) are incorporated in one or more pharmaceutically acceptable vehicles.
The therapeutic agent(s) may be included in the vehicle or one of the vehicles, but if the therapeutic agent is not covalently bound to the additional peptide of the first antibody, the therapeutic agent may be a material which is present in vivo in the general vicinity of the target site. The binding in accordance with the invention would then serve to concentrate the therapeutic agent onto the target site, thereby enhancing its activity against the target.
Where there are a plurality of antibody fragments which can combine spontaneously, it may be desirable to distribute them between a plurality of vehicles. The same applies when there is an antibody fragment able to bind to the therapeutic agent, and such agent itself. However, such precautions may not be necessary. An advantage of antibody fragments is that the complexes which form by antigen-antibody binding are fairly small and more stable than complexes with whole antibodies.
A product comprising a vehicle or vehicles containing therapeutic agent and antibodies could take a number of forms. If the target site is in the mouth, possibilities are mouthwash, toothpaste and a lozenge which will dissolve in the mouth. These forms of product could be used even when a plurality of vehicles are needed. For instance the product could be a two-component mouthwash which the user mixes immediately before use.
It could be a toothpaste having two components stored in the toothpaste container in such a way that they are kept separate or at least do not mix but are dispensed together and mix in the mouth of the user. Such two-component toothpaste products are known per se.
Another possible form of product providing a plurality of vehicles would be a lozenge to be sucked in the mouth, with the various components of the complex contained in separate regions of the lozenge. Three separate regions would preferably be used, and arranged so that the components of the complex were released in order, starting with the first (anti-target) antibodies. This would allow the complex to assemble on the target site.
Two vehicle forms could be used in combination as a way to provide a plurality of vehicles, e.g. toothpaste whose use is followed by a mouthwash or a lozenge.
When the therapeutic agent is an enzyme, the product may include a substrate for enzyme action, or it may rely on the enzyme substrate being present at the target site. Thus where the enzyme is glucose oxidase, directed at a target site in the mouth, the product could rely on dietary glucose as the enzyme substrate or it could itself incorporate glucose provided this was kept separate from the glucose oxidase.
If two enzymes are employed, the product may include substrates for both of them e.g. both glucose and a halide. Alternatively, only one substrate, or none at all may be included and reliance placed on substrate which comes from another source and happens to be present at the target site.
A preferred embodiment of the invention is illustrated by the attached diagram which shows the complex formed on a target site.
For attaching to the antigenic site 12 on the target 10 there is an Fv antibody fragment 14 with an additional peptide 16, which is several repeats of a shorter peptide 17, appended to the distal (C-terminal) end of one of the two peptide chains in the Fv fragment, so as to prolong thatchain.
The therapeutic agents are glucose oxidase (G.Ox) and horseradish peroxidase (HRP). Each is bound by a respective Fv fragment 18,20 with specificity for the enzyme concerned, and with a single repeat of the peptide 17 appended to one peptide chain of the Fv fragment.
The peptides 17 appended to the anti-enzyme Fv fragments 18,20 become linked to portions 17 of the peptide 16 on the anti-target Fv fragment 14 by means of F(ab)2 fragments 22 which bind specifically to these peptides 17. Since the F(ab)2 fragments 22 are divalent they can forma bridge attaching an anti-enzyme fragment, with attached enzyme, to the anti-target fragment 14.
Patent Citations
Non-Patent Citations
Referenced by
Legal Events
Original Image


text:
Mario Party is one of those game series that, like Rock Band, is best played accompanied with several friends and several bottles of something cheeky. The clue is in the title: It's a party. It isn't a game you're likely to play all alone, in your pants, at two in the afternoon. […] Read more »
In Lieu of a Review: Hyperdimension Neptunia Re;Birth1
Idea Factory International's list of issues presently being fixed posted on the Steam Community Hub, includes "background going black"; an issue which has unfortunately forced me into writing this featurette in lieu of a review. I was introduced to the Hyperdimension Neptunia series with Mk2, the second in the series. I […] Read more »
Tales from the Borderlands Review In Progress (ep1-2)
If you've read my previous reviews of other episodic games you'll probably know the rules by now. Each episode will get its own micro review and each is written based on the assumption that you've probably played the previous entry in the series, therefore you won't mind some plot points […] Read more »
Final Fantasy Type-0 HD Review: And They Will Know us by the Trail of Dead
As a Final Fantasy game, Type-0 HD, is well… different. If you're expecting something akin to other main line Final Fantasy games you will be sorely disappointed. Type-0 HD, is first and foremost an action RPG. If you were hoping for turn based combat and a ponderous 100+ hour campaign […] Read more »
Game Under Podcast Episode 61
In Episode 61 of the Game Under Podcast, Phil Fogg revisits his GOTY musings and laments his failure to include Child of Light by giving it a thorough goings-over with Tom Towers. They also offer their final thoughts on Hard Reset, and Phil briefly tackles Shadow Warrior. Tom Towers reviews Broken […] Read more »
New Jurassic World Gameplay Trailer Released
TT Games have released the first gameplay trailer for their upcoming blocky adaptation of the Jurassic Park quadrilogy. The new trailer and accompanying screens for LEGO Jurassic World, focuses almost entirely on showing us their take on Jurassic Park, which is probably for the best because who honestly gives a […] Read more »
Doable: The Book of Unwritten Tales 2 Review
The Book of Unwritten Tales 2 is actually the third game in the series; following on from The Critter Chronicles, the prequel to the original. As the title suggests, The Book of Unwritten Tales 2 is a sequel proper, set soon after the events of the original. Wilbur Weathervane, Aventasia's […] Read more »
Legend of Zelda: Majora's Mask 3D Review: Goron Day
Okay, internet. I have a confession to make. The first time I completed Majora's Mask was on the 3DS. When it first came out on the N64, it was just after I had jumped ship for the greener pastures of PC gaming in the late 90s. I tried to emulate […] Read more »
Game Under Podcast Episode 60
In episode 60 of the Game Under Podcast it's time for Phil Fogg and Tom Towers to talk about the best (and worst) games they played last year. More than simple lists, Tom and Phil put together an extensive set of awards, rewarding everything from the best rap song in […] Read more »
No Trigger Warning: Life is Strange Episode One Review
In Remember Me, Dontnod Entertainment's debut title, Memory Remixing was an original and intriguing gameplay mechanic: rearrange someone's memories so that, once their memories have been rearranged, they will act in the way that Nilin, Remember Me's memorist protagonist, needed them to. Although it was a mechanic on which much of […] Read more »