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Early Adverse Events and Attrition in SSRI Treatment: A Suicide
Assessment Methodology Study (SAMS) Report
Diane Warden, Ph.D., M.B.A.a,*, Madhukar H. Trivedi, M.D.a, Stephen R. Wisniewski, Ph.D.b,
Benji Kurian, M.D.a, Sidney Zisook, M.D.c, Susan G. Kornstein, M.D.d, Edward S. Friedman,
M.D.e, Sachiko Miyahara, Ph.D.b, Andrew F. Leuchter, M.D.f, Maurizio Fava, M.D.g, and John
Rush, M.D.h
aDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas,
bEpidemiology Data Center, Graduate School of Public Health, University of Pittsburgh,
Pittsburgh, Pennsylvania, USA
cDepartment of Psychiatry, University of California, San Diego, San Diego VA Medical Center,
San Diego, California, USA
dDepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
eDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania,
fDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at
UCLA, Los Angeles, CA, USA
gClinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts,
hDuke-National University of Singapore, Singapore
Adverse events during selective serotonin reuptake inhibitor (SSRI) treatment are frequent and
may lead to premature treatment discontinuation. If attrition is associated with early worsening of
side effects or the frequency, intensity, or burden of side effects, interventions to maximize
retention could be focused on patients with these events. Outpatient participants (n=265) with
nonpsychotic major depressive disorder entered an 8-week trial with an SSRI. At baseline and
week 2, specific side effects were evaluated with the Systematic Assessment for Treatment
Emergent Events – Systematic Inquiry, and at week 2 the Frequency, Intensity, and Burden of
Side Effects Rating globally assessed side effects. Attrition was defined by those participants who
left treatment after week 2 but before week 8. No specific week 2 side effect, either treatment
emergent or with worsening intensity, was independently associated with attrition. Global ratings
of side effect frequency, intensity, or burden at week 2 were also not associated with subsequent
attrition. Neither global ratings nor specific side effects at week 2 were related to patient attrition
during SSRI treatment. Other factors appear to contribute to patient decisions about continuing
with treatment.
* Corresponding author: Diane Warden, Ph.D., M.B.A., Department of Psychiatry, The University of Texas Southwestern Medical
Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9119. Tel.: +1-214-648-4614; fax: +1-214-648-0168.
Trial Registry Name: Assessing Treatment Emergent Suicidal Ideation in Patients With Major Depression (SAMS), Identification #
NCT00532103, http://www.clinicaltrials.gov
NIH Public Access
Author Manuscript
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Published in final edited form as:
J Clin Psychopharmacol. 2010 June ; 30(3): 259–266. doi:10.1097/JCP.0b013e3181dbfd04.
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attrition; adherence; adverse events; antidepressant; depression
Attrition or premature discontinuation during antidepressant treatment compromises
outcomes in both clinical trials and routine clinical settings, since even the most efficacious
medications will not work if patients do not take them. Up to two-thirds of patients
discontinue antidepressants in the first 3 months.1, 2 Not surprisingly, those who discontinue
are less likely to reach remission.3-5
Selective serotonin reuptake inhibitors (SSRIs) are currently the most frequently used
antidepressants6, 7; however, adverse events are commonly reported among SSRI users8, 9
and have been associated with discontinuation of antidepressants in both clinical trials and
naturalistic settings.10, 11
SSRIs increase the availability of serotonin (5-HT) at the synaptic cleft.12, 13 Central and
peripheral serotonin receptors mediate multiple functions including sleep, arousal, appetite,
sexual functions, gut motility, and smooth muscle tone.13-19 Many side effects may
therefore be attributed to serotonergic effects, among which gastrointestinal disturbances
such as nausea, vomiting, and diarrhea are frequently reported9, 20, 21; as are activating side
effects like insomnia, anxiety, and agitation; sedating side effects such as drowsiness20;
sexual dysfunction13; headache, cholinergic side effects such as sweating, dizziness9; and
In a meta-analysis of 95 randomized trials with over 10,000 patients, 12% discontinued
SSRI treatment reportedly due to side effects.6 Similarly, in a survey of 672 patients in
naturalistic treatment, 15% discontinued an SSRI in the first 3 months of acute treatment,
reportedly due to side effects.22 The incidence of side effects is the highest at the onset of
treatment,23 with side effects typically appearing within the first 2 weeks.24 In a naturalistic
setting, the most common side effects in the first 3 months of treatment with SSRIs were
drowsiness (38%), sexual dysfunction (34%), dry mouth (34%), headache (23%), dizziness
(23%), insomnia (22%), anxiety (19%), nausea (18%), and weight gain (17%), with all
symptoms except weight gain appearing within the first 2 weeks 64-85% of the time. All
side effects except dry mouth were considered bothersome by 33-67% of those reporting
them.24 In a second naturalistic study, patients were more likely to discontinue SSRIs when
side effects emerged, generally in the first or second week after treatment initiation.22
Others have noted upper gastrointestinal complaints such as nausea and vomiting,20, 25
usually appearing in the first or second week,26, 27 as most commonly related to
Side effect burden has also been associated with SSRI discontinuation. At week one, 58% of
85 patients receiving SSRIs reported at least one moderately severe side effect with a mean
number of 3.5 events.28 Many studies identify associations between side effects and dropout
through spontaneous patient report, physician report, retrospective interview, or do not
specify how side effect data were gathered or how it was determined whether they were
related to medication discontinuation.6, 22-24, 29
We previously reported that patients' concern or ambivalence about continuing in treatment
if they were to experience side effects was related to attrition, whether or not side effects
actually occurred.5 To the best of our knowledge, however, there are no studies evaluating
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the relationship between prospective, objective, patient self-report ratings of the emergence
or worsening of a comprehensive list of specific adverse events in the first weeks of acute
treatment and attrition during the course of that treatment. If attrition is associated with early
worsening of any specific adverse events or with the overall frequency, intensity, or burden
of side effects, interventions to maximize retention could be tailored for patients with these
events and used early in the course of treatment.
This report utilizes data from the Suicide Assessment Methodology Study (SAMS) to
address the following questions:
Is the emergence/worsening of specific adverse events early in treatment associated
with attrition? Independently associated with attrition?
Is the frequency, intensity, or burden of adverse events early in treatment associated
with attrition?
The relationship between early symptom improvement and attrition was also explored.
Materials and Methods
Study Description
SAMS was designed to develop easy-to-use patient- and clinician-rated measures of
suicidality and associated symptoms for use at initiation and dose escalation of SSRIs.
The study was part of the National Institute of Mental Health's Depression Trials Network. It
was conducted in accordance with the Declaration of Helsinki and was overseen by the
National Coordinating Center (NCC) (The University of Texas Southwestern Medical
Center), Data Coordinating Center (DCC) (Epidemiological Data Center at the University of
Pittsburgh), and 15 Regional Centers. The Institutional Review Boards at all these locations
approved and oversaw the study protocol. A Data Monitoring and Safety Board (DSMB)
evaluated the protocol and consents prior to study enrollment and monitored patient safety
throughout the study.
In all, 265 outpatients, 18-75 years old, with nonpsychotic major depressive disorder (MDD)
and a baseline 17-item Hamilton Depression Rating Scale (HRSD17) score of ≥ 1430, 31
provided written informed consent and were enrolled at 6 primary and 9 psychiatric care
sites nationally. Inclusion criteria were broad and exclusion criteria minimal to maximize the
generalizability of findings. All participants were treated for up to 8 weeks with one of the
following SSRI antidepressants at the discretion of the clinician: citalopram, escitalopram,
fluoxetine, paroxetine, paroxetine-CR, or sertraline.
The 16-item Quick Inventory of Depressive Symptomatology Clinician rated version32-34
(QIDS-C16) based on the nine DSM IV TR criteria for a major depressive episode to
evaluate symptoms of depression was collected at baseline, each clinic visit, and by phone in
the weeks in which there was no clinic visit. The Systematic Assessment for Treatment
Emergent Events – Systematic Inquiry35 (SAFTEE-SI), a 55-item self-report that rates the
side effects most commonly reported with the study medications as not present, mild,
moderate or severe was collected at baseline and each study visit. The SAFTEE also
includes one item rating how much all these side effects were bothersome or interfered with
daily activities. The Frequency, Intensity, and Burden of Side Effects Rating36 (FIBSER), a
three-item self-report measure which rates the frequency, intensity, and overall burden or
amount of interference in day-to-day activities and function due to the side effects
attributable to the medications was collected at clinic visits after baseline.
Further description of study methods and assessments is reported elsewhere.5
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Protocol visits were to occur at weeks 0, 2, 4, 6, and 8. Clinical decisions and dose
adjustments were made using Measurement-Based Care (MBC) guidelines.37-39 MBC
utilizes the assessment of depressive symptom severity based on the QIDS-C16 and
tolerability based on the SAFTEE and FIBSER at each visit to guide treatment decisions and
dose selection.
Attrition and Adverse Event Definitions
For the analysis of the association of adverse events and attrition, attrition was defined as
leaving the study at any time after the week 2 visit.
Worsening of adverse events was defined by a one point or greater increase in severity on
the SAFTEE from baseline to week 2. This included both emergence of an adverse event not
present at baseline and worsening of an event already present at baseline. Frequency,
intensity, and burden of side effects were scored from the FIBSER at week 2.
Analytic Methods
The population was characterized with descriptive statistics such as percentages and
measures of central tendency. The association between the emergence of adverse event
symptoms and attrition was assessed using a Chi-Square test or Fisher's Exact Test. A
stepwise logistic regression model was used to identify worsening symptoms (adverse
events) associated with lack of remission. The following characteristics were used in the
model to control for their potential confounding effect: baseline severity of depression,
presence of anxious symptoms, antidepressant medication, chronic depression, race, time in
study, and concomitant general medical condition (GMC) burden. The association between
the frequency, intensity, and burden of side effects and attrition was assessed using Fisher's
Exact Test. A t-test was used to compare the mean changes in symptom severity between
those who did and did not drop out.
Baseline characteristics of the sample are reported elsewhere.5 Frequency of use and dosing
of each SSRI are in Table 1. About 69% of the week 2 sample was female, 20% black, and
11% Hispanic with a mean age of about 42. The sample had substantial recurrent depression
(68%), chronic depression (30%), and had on average three concomitant GMCs. Of the
original study sample (n=264), 12 participants (5 %) dropped out before the week 2 visit and
44 (17 %) after the week 2 visit. Of those dropping out after week 2, 5 % (n=14) dropped
out between weeks 2 and 4, 6% (n= 15) between weeks 4 and 6, and 6 % (n=15) between
weeks 6 and 8.
Frequency of worsening of side effects from baseline to week 2 is shown in Table 2. Side
effects reported most frequently at week 2 included decreased appetite (27%), dry mouth
(26%), delayed orgasm (20%), stuffy nose (20%), loss of sexual interest (19%), drowsiness
(19%), and nausea/vomiting (19%).
In bivariate analyses without controlling for potential confounding factors, weight loss was
associated with dropout and sweating excessively with remaining in treatment (Table 3). No
other specific adverse events or the general bothersome nature of side effects as measured
by the SAFTEE were associated with attrition. Controlling for baseline depression severity,
anxious symptoms, antidepressant medication, chronic depression, race, concomitant GMC
burden, and time in the study, no specific adverse event was associated with attrition after
week 2.
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Frequency, intensity, and burden of side effects as measured by the FIBSER at week 2 were
not associated with attrition after week 2 (Table 4). There were limited numbers of patients
reporting severe intensity or burden of side effects.
Change in symptom severity scores on the QIDS-C16 between the baseline and week 2 visits
did not differ between dropouts and treatment completers (-4.57 (4.63) vs. -4.37 (4.01); p=
While conventional wisdom suggests that side effects are common, appear early in
treatment, and are associated with treatment discontinuation, the current findings suggest
otherwise. Although 41 of the most expected SSRI side effects (gastrointestinal, activating,
sedating, cholinergic, and sexual symptoms) were reported as worsening by 4-27% of the
sample that returned for the week 2 visit, none of the 55 symptoms queried by the SAFTEE
were independently associated with attrition during the remainder of the 8-week acute
treatment. Overall side effect frequency, severity, and burden as experienced by patients at
week 2, based on either the SAFTEE burden item or the FIBSER, were also not related to
Although side effects have been linked to attrition,6, 10, 22, 28, 40 attrition in this study was
independent of the prospectively measured presence, frequency, severity, or burden of side
effects at week 2, the time typically associated with the appearance of side effects.24, 26, 27
This is despite 25% of participants reporting side effects of at least moderate intensity and
14% reporting at least moderate burden. There were few participants, however, who
reported severe intensity or burden of side effects. Since bothersome or severe side effects
have been associated with treatment discontinuation,10, 22 the low frequency of severe side
effects in this sample could account for the failure to find an association between global
severity or burden of side effects and attrition.
Since there was no difference in early symptom change between dropouts and completers,
early lack of efficacy does not provide an alternate explanation for attrition in this sample.
There are a number of other possible explanations for the lack of association between side
effects and attrition in this study, in contrast to findings from prior studies. First, side effects
may be more prominent in decisions about continuing treatment for patients with limited
concomitant disorders in randomized controlled trials since they may have less experience
with treatment for chronic conditions and less tolerance for inconvenience. Second, studies
often identify only one main reason for treatment discontinuation,22 such as side effects. It
may be that patients consider multiple issues, weighing the benefits and psychological,
physical, financial and other costs of treatment in making a decision about treatment
continuation.41-44 Side effects may be one cost, but other perceived costs or benefits for
individual patients are not typically measured in studies or discussed in clinical practice.
Third, in this study the CRC inquired each week via a structured assessment5 about the
likelihood of retention and discussion and resolution of patient specific barriers to retention
likely occurred. There was also a high frequency of contact with a CRC including phone
contact three times a week for 4 of the 8 weeks of the study, and use of an algorithm that
specifically requires that side effects be addressed if indicated based on the FIBSER burden
score each week. Increased contact, use of an individual such as a coordinator to support the
patient, objective measurement and feedback to patients, and explicit focus on attrition are
similar to interventions associated with increased adherence in collaborative care
studies,45, 46 and these interventions may have mitigated the valence of adverse events for
patients in this study and/or reduced attrition.
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The trajectory of what happens to side effects after their emergence may also be more
important to keeping patients in treatment than the appearance itself or the overall
frequency, intensity, or burden of the side effects. A small prior study found that dropouts
and completers had the same frequency of adverse events; however, the completers
habituated to the side effects more rapidly than the dropouts.28 It may also not be the
presence or burden of side effects that is related to discontinuation but the impact of the side
effect on specific aspects of daily functioning.
Although adverse events are the rule rather than the exception,8 they may not be identified if
clinicians do not ask about them directly. Adverse events often resolve in 2-4 weeks,27
although for many patients they do not, suggesting a strong need to identify and treat side
effects aggressively when they do emerge or worsen early in treatment. It is therefore
important to use a systematic approach to identifying them at each treatment visit, such as
the use of a scale like the FIBSER so they can be treated when they do emerge or worsen
early in treatment.
Weight loss was associated with attrition in analyses that did not control for confounding
factors such as depression severity. It is possible that worsening of appetite (reported by
27%) and weight loss (reported by 16%) in this sample were related to worsening of
depression rather than an adverse event in response to medication. Depression severity has
been associated with attrition.4, 47 The few significant findings in the bivariate analyses may
also have been due to chance.
There are several limitations of this study. We did not evaluate worsening or emergence of
side effects or symptom change later than the week 2 visit. We also do not have side-effect
ratings for participants who left the study between baseline and week 2, or for participants
who missed their week 2 clinic visit. Only 12 participants dropped out between baseline and
week 2. but they may have experienced severe intensity or burden of side effects. The
distribution of side effects and/or their association with attrition may have been different
with a different SSRI distribution, with antidepressants from different classes, or in a
blinded clinical trial that includes a placebo. The frequency of side effects of moderate or
higher intensity or burden is lower than that reported in other studies.28 We also do not have
data in this study addressing patient perception of the costs and benefits of treatment or the
relationship of adverse events to patient perception of these costs.
A further limitation of the study is having sufficient power to detect a moderate to small
effect. For example, for a side effect that was relatively prominent, such as appetite
decrease, which had an overall prevalence rate of 26.7% (in a sample of 206, 55 with
appetite decrease and 151 without), there would be 80% power to detect a two-sided
difference of 16%, 18% and 20%, assuming the rate of drop out in those without an appetite
decrease was 10%, 15%, and 20%, respectively, with a type I error rate of .05. However, for
a side effect that was relatively rare, such as drooling, which had an overall prevalence rate
of 5.8% (in a sample of 206, 12 with drooling and 194 without), there would be 80% power
to detect a two-sided difference of 31%, 34% and 36%, assuming that the rate of drop out in
those without an appetite decrease was 10%, 15%, and 20%, respectively, with a type I error
rate of .05.
In summary, this study does not support the commonly held belief that the presence,
severity, or burden of side effects early in treatment with SSRIs is related to discontinuation
of treatment, at least in patients who have frequent visits with their physician and are
provided education and supportive medical management. By focusing on side effects, we
may not be identifying the attitudes or issues of most importance to patients or how they are
weighed in making a decision about treatment continuation. It may also be that what
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happens to side effects after their emergence is more related to dropout than the emergence/
worsening, intensity, or burden of side effects early in treatment. A consistent approach to
identifying side effects and aggressive management of side effects may be helpful in
keeping patients in treatment long enough to recover. However, further assessment of how
patients make decisions to remain in treatment is important.
This project was funded by the National Institute of Mental Health under Contract N01MH90003 to UT
Southwestern Medical Center at Dallas (P.I.: M.H. Trivedi). The content of this publication does not necessarily
reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names,
commercial products, or organizations imply endorsement by the U.S. Government. This analysis was also
supported in part by a National Alliance for Research on Schizophrenia and Depression Young Investigator Award
(D. Warden).
1. Katon W, Von Korff M, Lin E, et al. Adequacy and duration of antidepressant treatment in primary
care. Med Care. 1992; 30:67–76. [PubMed: 1729588]
2. Maddox JC, Levi M, Thompson C. The compliance with antidepressants in general practice. J
Psychopharmacol. 1994; 8:48–53.
3. Demyttenaere K, Adelin A, Patrick M, et al. Six-month compliance with antidepressant medication
in the treatment of major depressive disorder. Int Clin Psychopharmacol. 2008; 23:36–42. [PubMed:
4. Warden D, Rush AJ, Wisniewski SR, et al. What predicts attrition in second step medication
treatments for depression?: a STAR*D Report. Int J Neuropsychopharmacol. 2009; 12:459–73.
[PubMed: 18611293]
5. Warden D, Trivedi MH, Wisniewski SR, et al. Identifying risk for attrition during treatment for
depression. Psychother Psychosom. 2009; 78:372–9. [PubMed: 19738403]
6. Anderson IM. Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-
analysis of efficacy and tolerability. J Affect Disord. 2000; 58:19–36. [PubMed: 10760555]
7. Zajecka J, Amsterdam JD, Quitkin FM, et al. Changes in adverse events reported by patients during
6 months of fluoxetine therapy. J Clin Psychiatry. 1999; 60:389–94. [PubMed: 10401918]
8. Brambilla P, Cipriani A, Hotopf M, et al. Side-effect profile of fluoxetine in comparison with other
SSRIs, tricyclic and newer antidepressants: a meta-analysis of clinical trial data.
Pharmacopsychiatry. 2005; 38:69–77. [PubMed: 15744630]
9. Meijer WE, Heerdink ER, van Eijk JT, et al. Adverse events in users of sertraline: results from an
observational study in psychiatric practice in The Netherlands. Pharmacoepidemiol Drug Saf. 2002;
11:655–62. [PubMed: 12512241]
10. Bull SA, Hu XH, Hunkeler EM, et al. Discontinuation of use and switching of antidepressants.
Influence of patient-physician communication. JAMA. 2002; 288:1403–9. [PubMed: 12234237]
11. Demyttenaere K, Enzlin P, Dewe W, et al. Compliance with antidepressants in a primary care
setting, 1: Beyond lack of efficacy and adverse events. J Clin Psychiatry. 2001; 62 22:30–3.
[PubMed: 11599645]
12. Malagie I, Deslandes A, Gardier AM. Effects of acute and chronic tianeptine administration on
serotonin outflow in rats: comparison with paroxetine by using in vivo microdialysis. Eur J
Pharmacol. 2000; 403:55–65. [PubMed: 10969144]
13. Murphy GM Jr, Kremer C, Rodrigues HE, et al. Pharmacogenetics of antidepressant medication
intolerance. Am J Psychiatry. 2003; 160:1830–5. [PubMed: 14514498]
14. Banes A, Florian JA, Watts SW. Mechanisms of 5-hydroxytryptamine(2A) receptor activation of
the mitogen-activated protein kinase pathway in vascular smooth muscle. J Pharmacol Exp Ther.
1999; 291:1179–87. [PubMed: 10565840]
15. Ferguson JM. SSRI antidepressant medications: adverse effects and tolerability. Prim Care
Companion J Clin Psychiatry. 2001; 1:22–7. [PubMed: 15014625]
Warden et al.Page 7
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 8
16. Gorzalka BB, Hanson LA, Hong JJ. Ketanserin attenuates the behavioural effects of
corticosterone: implications for 5-HT(2A) receptor regulation. Eur J Pharmacol. 2001; 428:235–
40. [PubMed: 11675041]
17. Janssen P, Prins NH, Meulemans AL, et al. Pharmacological characterization of the 5-HT receptors
mediating contraction and relaxation of canine isolated proximal stomach smooth muscle. Br J
Pharmacol. 2002; 136:321–9. [PubMed: 12010782]
18. Landolt HP, Meier V, Burgess HJ, et al. Serotonin-2 receptors and human sleep: effect of a
selective antagonist on EEG power spectra. Neuropsychopharmacology. 1999; 21:455–66.
[PubMed: 10457543]
19. Pullar IA, Carney SL, Colvin EM, et al. LY367265, an inhibitor of the 5-hydroxytryptamine
transporter and 5-hydroxytryptamine(2A) receptor antagonist: a comparison with the
antidepressant, nefazodone. Eur J Pharmacol. 2000; 407:39–46. [PubMed: 11050288]
20. Beasley CM Jr, Koke SC, Nilsson ME, et al. Adverse events and treatment discontinuations in
clinical trials of fluoxetine in major depressive disorder: an updated meta-analysis. Clin Ther.
2000; 22:1319–30. [PubMed: 11117656]
21. Mackay FJ, Dunn NR, Wilton LV, et al. A comparison of fluvoxamine, fluoxetine, sertraline and
paroxetine examined by observational cohort studies. Pharmacoepidemiol Drug Saf. 1997; 6:235–
46. [PubMed: 15073774]
22. Bull SA, Hunkeler EM, Lee JY, et al. Discontinuing or switching selective serotonin-reuptake
inhibitors. Ann Pharmacother. 2002; 36:578–84. [PubMed: 11918502]
23. Linden M, Gothe H, Dittmann RW, et al. Early termination of antidepressant drug treatment. J Clin
Psychopharmacol. 2000; 20:523–30. [PubMed: 11001236]
24. Hu XH, Bull SA, Hunkeler EM, et al. Incidence and duration of side effects and those rated as
bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report
versus physician estimate. J Clin Psychiatry. 2004; 65:959–65. [PubMed: 15291685]
25. Aikens JE, Kroenke K, Swindle RW, et al. Nine-month predictors and outcomes of SSRI
antidepressant continuation in primary care. Gen Hosp Psychiatry. 2005; 27:229–36. [PubMed:
26. Linden RD, Wilcox CS, Heiser JF, et al. Are selective serotonin reuptake inhibitors well tolerated
in somatizing depressives? Psychopharmacol Bull. 1994; 30:151–6. [PubMed: 7831448]
27. Masand PS. Tolerability and adherence issues in antidepressant therapy. Clin Ther. 2003; 25:2289–
304. [PubMed: 14512135]
28. Demyttenaere K, Albert A, Mesters P, et al. What happens with adverse events during 6 months of
treatment with selective serotonin reuptake inhibitors? J Clin Psychiatry. 2005; 66:859–63.
[PubMed: 16013901]
29. Dunner DL, Wilson M, Fava M, et al. Long-term tolerability and effectiveness of duloxetine in the
treatment of major depressive disorder. Depress Anxiety. 2008; 25:E1–E8. [PubMed: 17621644]
30. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960; 23:56–62.
[PubMed: 14399272]
31. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol.
1967; 6:278–96. [PubMed: 6080235]
32. Rush AJ, Carmody TJ, Reimitz PE. The Inventory of Depressive Symptomatology (IDS): clinician
(IDS-C) and self-report (IDS-SR) ratings of depressive symptoms. Int J Methods Psychiatr Res.
2000; 9:45–59.
33. Rush AJ, Trivedi MH, Ibrahim HM, et al. The 16-Item Quick Inventory of Depressive
Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric
evaluation in patients with chronic major depression. Biol Psychiatry. 2003; 54:573–83. Erratum
p. 585. [PubMed: 12946886]
34. Trivedi MH, Rush AJ, Ibrahim HM, et al. The Inventory of Depressive Symptomatology, Clinician
Rating (IDS-C) and Self-Report (IDS-SR), and the Quick Inventory of Depressive
Symptomatology, Clinician Rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients
with mood disorders: a psychometric evaluation. Psychol Med. 2004; 34:73–82. [PubMed:
Warden et al.Page 8
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 9
35. Levine J, Schooler NR. SAFTEE: a technique for the systematic assessment of side effects in
clinical trials. Psychopharmacol Bull. 1986; 22:343–81. [PubMed: 3774930]
36. Wisniewski SR, Rush AJ, Balasubramani GK, et al. Self-rated global measure of the frequency,
intensity, and burden of side effects. J Psychiatr Pract. 2006; 12:71–9. [PubMed: 16728903]
37. Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for
depression using measurement-based care in STAR*D: implications for clinical practice. Am J
Psychiatry. 2006; 163:28–40. [PubMed: 16390886]
38. Trivedi MH, Daly EJ. Measurement-based care for refractory depression: a clinical decision
support model for clinical research and practice. Drug Alcohol Depend. 2007; 88 2:S61–S71.
[PubMed: 17320312]
39. Trivedi MH, Rush AJ, Gaynes BN, et al. Maximizing the adequacy of medication treatment in
controlled trials and clinical practice: STAR*D measurement-based care.
Neuropsychopharmacology. 2007; 32:2479–89. [PubMed: 17406651]
40. Machado M, Iskedjian M, Ruiz I, et al. Remission, dropouts, and adverse drug reaction rates in
major depressive disorder: a meta-analysis of head-to-head trials. Curr Med Res Opin. 2006;
22:1825–37. [PubMed: 16968586]
41. Becker MH, Haefner DP, Kasl SV, et al. Selected psychosocial models and correlates of individual
health-related behaviors. Med Care. 1977; 15:27–46. [PubMed: 853780]
42. Janz NK, Becker MH. The Health Belief Model: a decade later. Health Educ Q. 1984; 11:1–47.
[PubMed: 6392204]
43. Rosenstock IM. Why people use health services. Milbank Mem Fund Q. 1966; 44 127
44. Rosenstock IM. Historical origins of the health belief model. Monographs. 1974; 2:238–335.
45. Katon W, Von Korff M, Lin E, et al. Stepped collaborative care for primary care patients with
persistent symptoms of depression: a randomized trial. Arch Gen Psychiatry. 1999; 56:1109–15.
[PubMed: 10591288]
46. Vergouwen AC, Bakker A, Katon WJ, et al. Improving adherence to antidepressants: a systematic
review of interventions. J Clin Psychiatry. 2003; 64:1415–20. [PubMed: 14728101]
47. Warden D, Trivedi MH, Wisniewski SR, et al. Predictors of attrition during initial (citalopram)
treatment for depression: a STAR*D report. Am J Psychiatry. 2007; 164:1189–97. [PubMed:
Diane Warden, Ph.D., M.B.A. has owned stock in Pfizer, Inc. within the last five years.
Madhukar H. Trivedi, M.D. has been a consultant/speaker for Abbott Laboratories, Inc.;
Abdi Ibrahim; Akzo (Organon Pharmaceuticals Inc.); AstraZeneca; Bristol-Myers Squibb
Company; Cephalon, Inc.; Evotek; Fabre-Kramer Pharmaceuticals, Inc. Forest
Pharmaceuticals; GlaxoSmithKline; Janssen Pharmaceutica Products, LP; Johnson &
Johnson PRD; Eli Lilly & Company; Meade Johnson; Medtronic; Neuronetics; Otsuka
Pharmaceuticals; Parke Davis Pharmaceuticals, Inc.; Pfizer, Inc.; Sepracor; SHIRE
Development; VantagePoint; and Wyeth-Ayerst Laboratories. He has also received grant
support from Agency for Healthcare Research and Quality; Corcept Therapeutics, Inc.;
Cyberonics, Inc.; Merck; National Alliance for Research in Schizophrenia and Depression;
National Institute of Mental Health; National Institute on Drug Abuse; Novartis; Pharmacia
& Upjohn; Predix Pharmaceuticals; Solvay Pharmaceuticals, Inc.; and Targacept.
Stephen R. Wisniewski, Ph.D. has been a consultant for Cyberonics, Inc. (2005-09), ImaRx
Therapeutics, Inc. (2006), Bristol-Myers Squibb Company (2007-08), Organon (2007),
Case-Western University (2007), and Singapore Clinical Research Institute (2009).
Benji Kurian, M.D. has received research support from Targacept, Inc.
Warden et al.Page 9
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 10
Sidney Zisook, M.D. has received grant support from NIMH, Aspect Medical Systems, and
Pam Lab. He has received honoraria for speaking from GlaxoSmithKline and AstraZeneca.
Susan Kornstein, M.D. has received grants/research from the National Institute of Mental
Health, Bristol-Myers Squibb, Eli Lilly & Company, Forest Laboratories, Wyeth, Novartis,
Boehringer-Ingelheim, Pfizer, and Takeda. She has served on advisory boards for Wyeth,
Pfizer, Eli Lilly & Company, Bristol-Myers Squibb, Endo, and Forest Laboratories, and has
received book royalties from Guilford Press.
Edward S. Friedman, M.D. has served as a consultant for Pfizer Inc., Cephalon, ApotheCom
Associates, Medical Consulting Referral Inc., Innovative Solutions & Services, Inc.,
Primary Insight/Bear Stearns, and Medscape. He has received research support from Pfizer,
Sanofi-Aventis, Wyeth-Ayerst Laboratories, Northstar, Novartis, and Cyberonics. He has
served as a speaker for AstraZeneca, Bristol-Myers Squibb, Eli Lilly & Co,
GlaxoSmithKline, Pfizer, Wyeth-Ayerst, and the Neuroscience Education Institute.
Sachiko Mayahara, Ph.D. has no disclosures to report.
Andrew Leuchter, M.D. has provided scientific consultation or served on advisory boards
for Aspect Medical Systems, Eli Lilly and Company, Novartis Pharmaceuticals,
MEDACorp, AstraZeneca, Takeda Pharmaceuticals, and Merck & Co. He has served on a
speaker's bureau for Eli Lilly and Company and Wyeth-Ayerst Pharmaceuticals. He has
received research/grant support from the National Institute of Mental Health, the National
Center for Complementary and Alternative Medicine, Aspect Medical Systems, Eli Lilly and
Company, Novartis Pharmaceuticals, Wyeth-Ayerst Pharmaceuticals, Merck & Co., Pfizer,
Vivometrics, and MedAvante. He also is a minor shareholder in Aspect Medical Systems.
Maurizio Fava, M.D. has received research support from Abbott Laboratories; Alkermes;
Aspect Medical Systems; Astra-Zeneca; BioResearch; Bristol-Myers Squibb Company;
Cephalon; Clinical Trial Solutions; Forest Pharmaceuticals Inc.; Ganeden;
GlaxoSmithKline; J & J Pharmaceuticals; Lichtwer Pharma GmbH; Eli Lilly & Company;
Lorex Pharmaceuticals; NARSAD; NCCAM; NIDA; NIMH; Organon Inc.; PamLab, LLC;
Pfizer Inc.; Pharmavite; Roche; Sanofi-Aventis; Solvay Pharmaceuticals, Inc.; Synthelabo;
Wyeth-Ayerst Laboratories. He has provided advisory/consulting services to Abbott
Laboratories; Aspect Medical Systems; Astra-Zeneca; Auspex Pharmaceuticals; Bayer AG;
Best Practice Project Management, Inc.; BioMarin Pharmaceuticals, Inc.; Biovail
Pharmaceuticals, Inc.; BrainCells, Inc.; Bristol-Myers Squibb Company; Cephalon; Clinical
Trial Solutions, LLC; CNS Response; Compellis; Cypress Pharmaceuticals; Dov
Pharmaceuticals; Eisai, Inc.; EPIX Pharmaceuticals; Euthymics Bioscience, Inc.; Fabre-
Kramer Pharmaceuticals, Inc.; Forest Pharmaceuticals Inc.; GlaxoSmithKline; Grunenthal
GmBH; J & J Pharmaceuticals; Janssen Pharmaceutica; Jazz Pharmaceuticals; Knoll
Pharmaceutical Company; Labopharm; Eli Lilly & Company; Lorex Pharmaceuticals;
Lundbeck; MedAvante, Inc.; Merck; Methylation Sciences; Neuronetics; Novartis; Nutrition
21; Organon Inc.; PamLab, LLC; Pfizer Inc.; PharmaStar; Pharmavite; Precision Human
Biolaboratory; Psychogenics; Psylin Neurosciences, Inc.; Ridge Diagnostics, Inc.; Roche;
Sanofi-Aventis; Schering Plough; Sepracor; Solvay Pharmaceuticals, Inc.; Somaxon;
Somerset Pharmaceuticals; Synthelabo; Takeda; Tetragenex; TransForm Pharmaceuticals,
Inc.; Transcept Pharmaceuticals; Vanda Pharmaceuticals Inc.; Wyeth-Ayerst Laboratories.
He has been on speaking bureaus for Adamed, Co.; Advanced Meeting Partners; American
Psychiatric Association; American Society of Clinical Psychopharmacology; Astra-Zeneca;
Belvoir; Boehringer-Ingelheim; Bristol-Myers Squibb Company; Cephalon; Forest
Pharmaceuticals Inc.; GlaxoSmithKline; Imedex; Eli Lilly & Company; Novartis; Organon
Inc.; Pfizer Inc.; PharmaStar; MGH Psychiatry Academy/Primedia; MGH Psychiatry
Warden et al.Page 10
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 11
Academy/Reed-Elsevier; UBC; Wyeth-Ayerst Laboratories. Dr. Fava has equity holdings
(excluding mutual funds/blinded trusts) with Compellis, patent applications for SPCD and
for a combination of azapirones and bupropion in MDD, and copyright royalties for the
MGH CPFQ, SFI, ATRQ, DESS, and SAFER.
A. John Rush, M.D. has been a consultant for Forest Pharmaceuticals, GlaxoSmithKline,
Organon USA Inc., Pfizer Inc., and Wyeth-Ayerst Laboratories Inc.; has been on the
speaker's bureau for Forest Pharmaceuticals, Inc. and GlaxoSmithKline; and has equity
holdings (excluding mutual funds/blinded trusts) in Pfizer Inc.
Warden et al.Page 11
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 12
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Warden et al.Page 12
Table 1
Medications and Dosing
Study medications usedN (%)
At baseline
Citalopram98 (50.5)
Escitalopram30 (15.5)
Fluoxetine32 (16.5)
Sertraline25 (12.9)
Paroxetine 8 (4.1)
Paroxetine CR1(0.5)
At Week 2
Citalopram 106 (51.7)
Escitalopram31 (15.1)
Fluoxetine34 (16.6)
Sertraline25 (12.2)
Paroxetine9 (4.4)
Paroxetine-CR N/A
Study Medication Dose Mean (sd)
At Baseline
Citalopram 17.7 (4.3)
Escitalopram 10.0 (0.0)
Fluoxetine18.5 (3.9)
Sertraline 48.6 (5.8)
Paroxetine11.5 (4.7)
Paroxetine-CR 10.0 (--)
At Week 2
Citalopram21.1 (7.0)
Escitalopram 10.0 (0.0)
Fluoxetine20.3 (5.6)
Sertraline74.1 (29.0)
Paroxetine15.6 (5.3)
Paroxetine-CRN/A (--)
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
Page 13
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Warden et al.Page 13
Table 2
Frequency of Worsening of Adverse Events at Week 2 (N=206)*
Adverse Event% Adverse Event%
Appetite decrease26.7 Trouble sleeping12.1
Dry mouth 26.2Blurred vision 12.1
Delayed orgasm 20.4 Constipation11.7
Stuffy nose 19.9 Difficulty finding words11.7
Loss of sexual interest 19.4Muscle cramps 11.7
Drowsy 18.9 Trouble catching breath11.2
Nausea/vomiting 18.5 Clenching of teeth11.2
Trouble sitting still18.0Concentration 11.2
Sweating 17.0 Appetite increase11.2
Strange taste in mouth17.0 Hot flashes11.2
Sleep disturbance16.5Numbness 10.7
Nervous16.5 Feeling strange10.2
Problems with sexual arousal15.5 Abnormal sensations 10.2
Unable to sit still15.5 Irritable9.7
Stomach discomfort15.5 Unsteadiness8.7
Weight loss 15.5 Muscle twitching 8.3
Headache 14.6Difficulty starting urination 8.3
Tremor 14.1Diminished mental acuity 8.3
Weariness/fatigue14.1 Hair loss7.3
Poor memory 14.1 Ringing in ears 7.3
Dizziness 13.6Chest pain 6.3
General side effect bothersome13.6Bruising 6.3
Weight gain13.1 Drooling5.8
Heartbeat rapid13.1
Diarrhea 13.1
Need to urinate13.1
*As measured by the Systematic Assessment for Treatment Emergent Events – Systematic Inquiry (SAFTEE)
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
Page 14
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NIH-PA Author Manuscript
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Warden et al.Page 14
Table 3
Percent of Participants With or Without Adverse Events That Dropped Out1
Presence of Adverse Event
% Dropout2
Presence of Adverse Event
% Dropout
Presence of Adverse Event
% Dropout
Appetite decrease
Poor memory
Dry mouth
Feeling strange/unreal
Delayed orgasm
Fluid retention
Abnormal sensations
Stuffy nose
Weight gain
Loss of sexual interest
Heartbeat rapid
Muscle twitching
Urinary frequency
Difficulty starting urination
Trouble sitting still
Diminished mental acuity
Sweating excessively
Hair loss
Strange taste in mouth
Trouble sleeping
Ringing in ears
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.
Page 15
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Warden et al.Page 15
Presence of Adverse Event
% Dropout2
Presence of Adverse Event
% Dropout
Presence of Adverse Event
% Dropout
Nightmare/sleep disturbance
Blurred vision
Chest pain
Problems with sexual arousal
Difficulty finding words
Drooling/increased salivation
Unable to sit still
Muscle cramps
Menstrual irregularity
Stomach discomfort
Trouble catching breath
Skin rash
Weight lossa
Clenching of teeth
Slurred speech
Trouble concentrating
Hearing/seeing things
Appetite increase
General side effect bothersome
Hot flashes
1Dropout rates for participants who did or did or did not report the adverse event. For example, among participants with an appetite decrease, 18.2% dropped out; among participants with no decrease in
appetite, 13.3% dropped out.
J Clin Psychopharmacol. Author manuscript; available in PMC 2011 June 21.


text:
June 20, 2010
Preseason Top 120 Countdown: Nos. 105-101
Rivals.com Staff
Rivals.com College Football
Here is the fourth part of Rivals.com's 1-120 countdown for 2010; today, we look at teams ranked 101st through 105th.
We're starting at the bottom, and the first two weeks of rankings will be in groups of five. We'll do a daily countdown from 50th to first, with our No. 1 team to be unveiled Aug. 19 -- two weeks from the beginning of the season.
The team rankings were compiled by football writers Olin Buchanan, Tom Dienhart, David Fox, Mike Huguenin and Steve Megargee. They look forward to your emails.
Talk about it in Basketball Recruiting Board
Basketball Recruiting News
Starting Five: Big weekend at Cal
Cal lands Rivals150 wing
No rush for Rakocevic
Rowan gunning for a title
Rivals.com is your source for: College Football | Football Recruiting | College Basketball | Basketball Recruiting | College Baseball | High School | College Merchandise
Site-specific editorial/photos �2012 Yahoo! Inc. All rights reserved. This website is an officially and independently operated source of news and information not affiliated with any school or team.
About | Advertise with Us | Contact | Privacy Policy | About our Ads | Terms of Service | Copyright/IP policy | Yahoo! Sports - NBC Sports Network
Statistical information �2007 STATS LLC All Rights Reserved.

subset: commoncrawl


text:
1938 Ford COE Crew Cab Currently owned by Hall of Fame Rocker, James Hetfield of Metallica Chassis Number: 799T1787395 1938 was the first year that Ford came out... More
YOU ARE VEIWING ONE OF THE NICEST TOURING SEDANS BEING OFFERED FOR SALE TODAY .IT HAS A LONG OWNER HISTORYOF 38 YEARS IN SUNNY... More
1938 Ford 81ANice American Classic in excellent condition inside and out. Features - 2 door deluxeFrame off reconstruction Ford Mustang II Front End9" Ford... More
Packard 1938 woody wagon, was on display at Pebble Beach Concours d'Elegance, beautiful restoration, excellent wood inside & out, emerald green paint; chrome, engine... More
For sale in our Detroit area showroom is a truly wild 1938 Austin Bantam Race Car. This sinister hot rod is powered by a... More
This 1938 Chevrolet two door sedan is an all-steel rod that gets big points for style and comfort. Far less common than Fords, this... More
The first Bentley model produced after Rolls-Royce's acquisition of the Bentley company, the "Derby Bentleys" were so named because they were built at Rolls-Royce's... More
1938 Chevrolet Sedan Delivery Northwest Classic Auto Mall advertises this vehicle for the owner. If you are interested in this vehicle or have any questions, please... More
1938 Chevrolet Coupe VIN 9HB0611475 Total custom 1938 Chevy Coupe! Mechanics 350ci Engine Casting #3970010, Suffix K12 19 TKY 11301230 700R4 Transmission Casting... More
• Sold new by Packard of Manhattan May 22, 1938 • Classic Car Club of America Senior winner • One of only 157 Packard V-12s in... More
1938 Maybach SW38 Roadster with Disappearing Top Coachwork by Spohn Chassis no. 2055, Engine no. 11164 Black with Oxblood Leather Interior Maybach is among the most storied... More
GR Auto Gallery is pleased to present this 1938 Studebaker Commander Sedan for consideration. The Commander was initially dropped from Studebaker's product line in... More
38 CHEVY STREET RODAll steel body, Corvette LT1 engine, 700R4 trans, 350 Posi rear end, 4 wheel power disk brakes, Custom Leather interior, AC, heat,AM/FM, power... More
If Style, Elegance, and Grace is what you desire, LOOK NO FURTHER!!! This 1938 Packard Eight 1601 Convertible Sedan in Deep Loyola Maroon and... More
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The Cadillac series 75 model line was best expressed in Fleetwood livery, appearing nothing less than fit for a king. Cadillac had completely absorbed... More
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1938 Mercedes-Benz 540K Cabriolet 'A' Coachwork by Sindelfingen Chassis no. 169396 5.4-liter supercharged inline eight-cylinder Four-speed manual transmission Servo-assisted hydraulic brakes Delightful patina Two long-term owners One of 83 540K Cabriolet 'A'... More
1938 Buick Special Sedan, only 20,000 miles, all original, totally 100% rust free, amazing Botticelli Blue paint, immaculate Tan broadcloth interior, flawless woodgrain, nice... More
May we have the attention of all Packard Aficionados? 1938 Packard 1668 Eight, Here is a car that does not come to market often. Offered... More
This 1938 Ford Deluxe 2dr 2 Door Sedan features a 350 V-8 8cyl Gasoline engine. It is equipped with a 3 Speed Automatic transmission.... More
1938 Chevrolet Cabriolet Redesigned just a year earlier, the 1938 Chevrolet saw only modest changes such as a new grille, and many rare, valuable and... More
1938 Packard phaeton, fully restored, great driver, sacrifice at only... More
1938 Ford Deluxe 4-door, 1 owner, 57,000 miles, solid, totally orig, 85 hp motor, great driver, barn find, sacrifice at only... More
If you're looking for a completely wild hot rod to take out on the streets and turn heads, this 1938 Dodge Coupe is the... More
Same local family owned for years, newer tires, newer int, V8, 4spd, good paint and well maintained, runs great.... More
The Series 80 Roadmaster was an all-new model for 1936 that featured a 120-horsepower version of Buicks Fireball straight-eight hydraulic brakes and an all... More
1938 Buick Roadmaster phaeton, original family owned car since new, chauffeur driven, low mileage, low production, only 350 made, dual cowl, always garaged since... More
1938 Ford 1/2 Ton Custom "Old School Hotrod" Truck This immaculate 1938 Ford 1/2 ton custom pickup truck has recently undergone a meticulous frame-off restoration and... More
Very nice ALL ORIGINAL 38' Hudson Runs and drives very good Odometer reads 25,600 and that is believed to be the actual mileage Body and interior are... More


text:
How Some Oreos Inspired My Career Dreams
By Alina Tang
When I first entered college, I had never heard of Mondelez International. I had no idea that it recently branched off Kraft Foods, that it employs more than 105,000 people globally, and that it is one of the world's leading snack companies (#1 in biscuits, chocolate, candy and powdered beverages; and #2 in gum and coffee).
But today, Mondelez International has easily become my dream company to work for, not only because of its unique work environment and corporate culture, but because it has inspired me to pursue global marketing as a future career. And it's all because of a certain Chief Marketing Officer by the name of Haiyan Wang.
I first met Haiyan when my Global Leadership Program organized a company visit to Mondelez International's Shanghai office. Nicknamed the marketing guru of her team, Haiyan explained how she successfully launched the Oreo cookie in China.
Because Chinese consumers have very different snack preferences from Western ones, many changes were made to fit local tastes, including lowering the sweetness level, altering the packaging, and varying the sizes, shapes, and colors.
After a long year of experiments and tests, Haiyan and her team finally settled on the perfect recipe, and the Oreo became a hit. From taking time to understand what the locals want, to actually implementing the marketing strategies, this entire process was fascinating to me because it demonstrated that even the boldest and strangest ideas can materialize into an amazing reality—like the Green Tea Oreo!
Ever since hearing Haiyan's inspirational Oreo story, I have not stopped thinking about her drive to build a global brand, and how much I would love to head my own promotional campaign.
Shortly after coming back from the trip, I applied to the subsequent GLP Summer internship and was lucky enough to land a marketing position with Multipure Drinking Water Systems in Shanghai! For two months, I conducted industry research on different product categories, created a drinking water habits survey for locals, and finally, developed a go-to market plan to introduce U.S. made water filters to Asian markets.
Even though I do not necessarily have an interest in water filters, my hands-on experience with Multipure only further solidified my desire to pursue global marketing.
Someday, I hope to use what I've learned from Mondelez and Multipure to dive into industries that I'm passionate about, such as food, fashion, and entertainment, but on the international level.
As the world becomes more interconnected and interdependent, it is crucial to be able to understand how people conduct business across different cultures. Because I enjoy human interaction and following international trade, I would love to launch popular American products in foreign countries and vice versa.
To me, the build-up of a project on a global scale is incredibly exciting. I bet every time Haiyan walks into a Walmart or any kind of Chinese supermarket, she can see all her hard work come to life in the stacks of Oreos on grocery aisles and kiosks. There's nothing like looking at a final product and thinking, "Wow, that was me. I did that."
My dream is to strengthen my global business acumen and skillset, so that I can be the chief marketing officer of a multinational company, just like Haiyan. The combination of her sharpness, charisma, and understanding of international markets is extremely inspirational to me, and I believe it is the reason she has become so successful.
I can only hope that one day, I will be known as a marketing guru just like her.
Alina Tang will graduate from USC in 2016. She is majoring in business administration and plans to work in the Management Development Program at Mondelez International and gain more experience in global marketing.


text:
Listen to free music played by neil_longmayyourun
Blip.fm is internet radio made social. It's easy to search for, play, and discover free music recommended by real people. Join today to create your own free station and start listening to @neil_longmayyourun.
marcdennis gave props on Jan 19 at 1:13 pm
GAY_AMSTERDAM gave props on Jan 19 at 1:11 pm
What other DJs are saying about Bob Marley- Exodus (Live) 1979
Clair_de_Lune Bob Marley- Exodus (Live) #1979
Tropicsz4 " When one door is closed, don't you know, another is open." Bob Marley rb@SeanH: "Didn't know that! : )@ellendiane: "you k now it is his bday:) "" (reblip)
SeanH Didn't know that! : )@ellendiane: "you k now it is his bday:) rb@SeanH" (reblip)
ellendiane you k now it is his bday:) rb@SeanH (reblip)
Fangbaby hey blu @bluejulius
DaveDoyle Bob Marley - Exodus rb@scotlandlover: @FOGGIELOANER: (reblip)
FOGGIELOANER Bob
LOVE4ME Yep @SambaJazzen: ""Open your eyes (and look within)"" (reblip)


text:
A group for discussion and recommendation of Comic Books and other things that fall under the category of Sequential Art.
For those who love to read, and talk about it. Any author, any genre... discuss it!
We welcome all who are active in and around the Great Lakes, and just as important, have intentions of being active in the group. Just send the owner a message letting him know why you want to join. And to stay in all you need to do is remain active ...
Anime > real life
This group is for people with tattoos , people who do tattoos , and people who might be thinking of getting a tattoo . You can talk about who your favorite artist is , or where the best shop in your town is located . Share a picture of your new work , or ask someone ...
This is the place for Star Wars fans to congregate and discuss the greatest achievement in american culture and film. EMPIRE STRIKES BACK, GREATEST MOVIE EVER!!!!
anything to do with photography, digital or analog. technical discussion, photoshop tips, post your photos for critique, links to and discussion of photographers you love. a catch all group for everything photographic.
You can't do that!


text:
Oxford Oximiser 600 - the essential 12-volt motorcycle battery chargerQuickly charges battery at 600mA/hour until full and maintains a gentle trickle charge to keep battery optimized. Quick-connect leads included for easy coupling to the Oximiser between rides. Wall Bracket and extra long cables make for ease-of-use in your garage. Learn More$39.95
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SW-MOTECH Bags-Connection EVO Speedpack motorcycle luggage system
The Speedpack is one of our larger rear seat bags, offering 75 liters to 90 liters capacity. Fits bikes with a narrow tail section. This is for the rider who likes to pack everything but the kitchen sink.Learn More$435.00
SW-MOTECH Bags-Connection Racepack motorcycle luggage system
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text:
About AricTheRed
See! No inflation....
"The money was taken out of circulation so it could not be used for other illegal activity."
- Governor Matt Mead
They must've take then big wad of sweaty money and doused it with Bakken crude and burt it in-place.
Or is it perhaps still in circulation? Able to be used for criminal activity?
"We will not stand by idly as the White House, using the FCC, attempts to advance rules that imperil the future of the Internet..."
Remeber Campers, when you're playing Stupid, it is always best to double-down on an 11!
Denied service because the service provider does not like your position regarding constitutionally protected activities?
Can't get in to a restaurant cause of your religion, "race", or sex?
Want to have a fabulous cake at your same sex, non-denominational Wedding?
Want to live in a custom built home, in a certain neighborhood, where only decent pink folk currently live?
Want to ship your little CNC milling machine that your customers may make firearms components with, even the little bit of metal that the ATF considers to be the regulated firearm itself, which is perfectly legal under federal law?
Call the ACLU defenders of The People!!! Oh wait never mind…
From the ACLU's site:
https://www.aclu.org/racial-justice_prisoners-rights_drug-law-reform_immigrants-rights/second-a mendment
Gun Control
Updated: 1/17/2013
The Second Amendment provides: "A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed."
Given the reference to "a well regulated Militia" and "the security of a free State," the ACLU has long taken the position that the Second Amendment protects a collective right rather than an individual right. For seven decades, the Supreme Court's 1939 decision in United States v. Miller was widely understood to have endorsed that view. This position is currently under review and is being updated by the ACLU National Board in light of the U.S. Supreme Court decision in D.C. v. Heller in 2008.
In striking down Washington D.C.'s handgun ban by a 5-4 vote, the Supreme Court's decision in D.C. v. Heller held for the first time that the Second Amendment protects an individual's right to keep and bear arms, whether or not associated with a state militia.
The ACLU disagrees with the Supreme Court's conclusion about the nature of the right protected by the Second Amendment. However, particular federal or state laws on licensing, registration, prohibition, or other regulation of the manufacture, shipment, sale, purchase or possession of guns may raise civil liberties questions.
"Wanting the backdoor automatically, makes you the the "bad guy" as far as this lone voice is concerned"
Wifey says the same thing!
District Attorney John Peck - "I've never seen it before, but it was a key piece of evidence that led investigators to the defendant."
'Casuse they never would have busted this one open without someone going all Weekend at Bernie's with the victim...
one Etsy seller - "We were shocked. And we were scared. We didn't even make enough money for a lawyer and this had seemed like such a harmless and fun idea"
I once uttered the same words, and then, suddenly, the redcoats were coming...
"...they can't gag a well-trained attorney?"
I've seen 50 Shades of Grey, I know you can gag a well-trained attorney.
That is step one in the training process.
I've just realized, I've been an ebay employee for over 10 Years!
I'm putting that on my resume, and I want my health insurace expenses reimbursed too ebay! Now!
and not just pull it down off the shelf and dust it off.
In 'merica...
September 11, butt-heads fly aeroplane in to buidings and people die.
October 2, (21 days later) butt-heads dust off ready-made, 340 page or so long, jsut add terrorist attack, horrible law that will generate more terrorists.
In Canada...
October 22, 2014 butt-heads try and shoot lots of fols, and suck at it.
January 30, 2015, (40 days later) butt-heads announce that, at some time in the indeterminate future, they will introduce a stupid new law that will generate more terrorists.
1970s era passenger vehicle! track that with your super duper computer thingy in my car...
"He grew up and became a highly respected police officer."
If he's on the NYPD her earlier prediction of "international terrorist" might still be accurate.
The only way I can see this one getting granted is if they manage to pull it off without violating Amazon's patent, as I'm sure they have photographed something on seamless white (but maybe they were smart, and used seamless grey, or a green screen) with which they prepared their application...
Regarding my days at that little 'ole terrorist oganization called DHS, and that blackmail you are so concerend about...
We already did that, with paychecks.
Compared to your previous communication style your new style of suspiciously polite communications have been flagged as terroristic threats.
As such, armed drones are now being vectored to the wedding recption you are currently atteding. Any attempted denial, by asserting your rights confims your enemy combatant status and authorizes your imeddiate "redaction". Any non-denial also confirms your status as an extremest as well. Now bend over and kiss your ass goodbye citizen!
As a former Marine I am shocked sir!
How is it that while I defended Truth, Justice, and the American way of life, (freedom omitted on purpose) all while lowering personal standards and hooking up with the chubby chicks you still complain?
I tried to take'em all off the market for you, yet you are still not satisifed, Figures. ;-)
I had to, just had to check out the "embarrassing info" link.
Just think how pissed Michael Pavlic must be to be paid less than Michael Barker, all because of the alphabetical payroll scheme there @ Sony.
If .gov get the supremes to get the bar set rollerskate-limbo low what does this expose the satirist to? Especially those ones that are really bad at it? Like Deputy Dickwad. I hear he jsut threatened the Rams for their hands-up bit...
This is why we NEED non disclosure agreements!
You are a shining example of an inorant citizen that need something taught to them.
So listenup fukwads..
If the phone or other cell service wireless device, car, ipad, laptop data card, what ever, is not moving you move your stingray, take multiple DF (Direction Finging) readings continuiously that feed in to, ironically, the stingray's iPad app, and blammo perp caught!, along with all of the sexts you can shake your stick at!
Being better than all you peeons IS AWESOME!
'cause the prolly taught some Teahadis to avoid the TSA behavior detection officers too!
So charge'em with providing material support to terrorists while they are at it!
Now I've taken their course and used plenty of goldenseal, and cathed myself with the urine of a 5yr old to keep my job, but that was all different.
'Cause I'm here to protect you Citizens!


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Lutheran Church
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News on Lutheran Church continually updated from thousands of sources around the net.
Lutheran pastor resigns after being linked to threatening email
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Friday Mar 27 | The New Zealand Herald | Comment?
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Create neighborhood trust
25 Celebs Who Lost Their Religion
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Watch Woman Writhe In Pleasure When Her Pussy Is Rubbed
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I liked the Rug but i was very disappointed it wasn't round round, it is kinda wavy and it's not a round circle but kept it since it was in my small hallway where no-one sees it, but love the softness and color
It actually matched perfect; I thought it would be more like a Flokati rug but it is oatmeal colored. Very natural looking and prettyLove this rug. Do wish it was bigger now though.
overall a good rug and buy. not perfect. yarns do not come fully to the edge of one part but very hard to detect and hid it under the couch. I am not sure i would place this in a high traffic area.....great as an accent.
This rug is great. The color and quality are what I expected. This rug is a great deal. I have searched for shag rugs and they are generally pretty pricey. This one does not look cheap... only your wallet will know how much you saved. Our dog loves this rug and it goes well in our study also! I don't have a rug mat under it and it seems to be fine without it.
I am very pleased with this rug for the price I paid for it. I'm happy with the color and the feel of the shag. Great buy!
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Obituary & Guest Book Preview for Colonel John Max Pickarts
Colonel John Max Pickarts Obituary
Published in Idaho Statesman on Mar. 3, 2013
First 25 of 918 words
: Colonel John Max Pickarts 1924 ~ 2013 Colonel John Max Pickarts, US Army, (Retired), passed away February 25, 2013 in Boise, Idaho, of chronic complications...
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Tag "Nevada"Back to homepage
CA, Tesla and the slippery slope to crony capitalism
The decision of Tesla to locate its "gigafactory" in the Reno area instead of California offers critics of the state's business climate a chance to once again knock Gov. Jerry Brown and other state leaders for failing to care aboutRead More
A Tale of Two States, CA and NV: Part II
This is Part II in a series of stories about Nevada's economic strategy. To read the first installment, click here. In September, Nevada Gov. Brian Sandoval delivered the Republican Party's weekly address. In the video, which lasted less than sixRead More
California blinks in Tahoe dispute
Since California and Texas are large and populous states controlled by different parties with nearly polar opposite political ideologies, pundits are fond of comparing the two. After all, different policies for taxation, education, regulation and myriad other issues have resultedRead More
Californians fleeing to Nevada
Taxes have consequences. That's something tax increasers don't understand. Remember how Gov. Jerry Brown and others campaigned last year for Prop. 30, saying millionaires had to "pay their fair share" (even though "millionaire" was defined, in California math, as someoneRead More
CA now suffers nation's worst unemployment 16
March 25, 2013 By John Seiler Probably for the first time since it became a state in 1850, California now suffers the nation's worst unemployment rate, at 9.8 percent in January. It's tied with Rhode Island for that number, althoughRead More
California unemployment third worst at 10.7 percent 0
Aug. 17, 2012 By John Seiler In numbers released this morning by the Bureau of Labor Statistics, California's unemployment in July remained the same as in June, 10.7 percent. But that was an improvement from the 11.9 percent of JulyRead More
Jerry Brown Killed This Business 0
Gov. Jerry "Jobs Killer" Brown quickly is replacing departed adulterer Gov. Arnold Schwarzenegger as California's second-worst governor. (Gov. Earl Warren always will be the state's worst governor for stuffing loyal Japanese-Americans into concentration camps during World War II.) The MercuryRead More
Zombie Recovery: CA Jobless Rate Jumps 0
JULY 22, 2011 By JOHN SEILER California is suffering what I call a "Zombie Recovery." The state economy is walking, but dead. Today the U.S. Bureau of Labor Statistics released new numbers for June 2011 showing that California's unemployment roseRead More
Gov. Brown Chases Business to Vegas 0
John Seiler: Gov. Jerry Brown and the other anti-business fanatics in the Legislature and government unions just don't get it: If you attack businesses, they leave California. A recent departure was Pixel2Canvas, which split Lake Forest for North Las Vegas.Read More


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Wilson Combat Firing Pin Spring 1911 Extra Power
Product #: 597233 Wilson Combat #: 26 UPC #: 874218000585
Product Information
The Firing Pin Return Spring should be replaced every 5,000 rounds to keep your 1911 in proper working order. Wilson Combat's Extra Power Spring will help reduce the risk of accidental discharge should the gun be dropped, but it will not affect reliable ignition. Drop-in.
Technical Information
Material: Steel
Gunsmithing Required: No
Technical Information
Material: Steel
Gunsmithing Required: No
Delivery Information
The total weight of the product, including the product's packaging as it sits on our shelf. Since some products ship directly from the Manufacturer, their weight may be unavailable. Because of variations in the manufacturing process, similar products may have differing weights. Unless the product is designated as "Ships Alone", Shipping Weight does not include the shipping box or packing materials associated with your order.
Product ships from MidwayUSA, separate from any other products on your order due to its size. Products that are Shipped Alone incur separate "Per Order" and "Per Pound" shipping charges.
Product is regulated by the US Department of Transportation (DOT) and cannot be shipped via USPS or air shipping methods. DOT-Regulated products must ship UPS Ground.
Product is restricted by shipping carriers and cannot be shipped to certain locations or via certain shipping methods.
Additional shipping charge for HazMat products. Carriers charge extra to ship packages with products they consider hazardous, such as reloading powder and primers.
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The statements and opinions expressed within Customer Reviews reflect each author's personal perspective and do not imply endorsement by MidwayUSA, its Employees or any other organization. Customers should in no way infer that MidwayUSA has validated review information as safe, accurate or appropriate.
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text:
Hang tight!
Recipe by Dietz & Watson
"Corn muffins with diced ham, Cheddar cheese and chives make a great brunch treat or a side with chili or stew."
Hmm. None of these ingredients are on sale today.
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2 (8.5 ounce) packages
of your favorite corn muffin mix
1 cup
finely diced Dietz & Watson Uncured All Natural Classic Dinner Ham
1/8 cup
Dietz & Watson NY State Garlic Cheddar
1/4 cup
finely chopped chives or scallion greens
* Percent Daily Values are based on a 2,000 calorie diet.
Ham and Cheddar Corn Muffins
Serving Size: 1/12 of a recipe
Servings Per Recipe: 12
Amount Per Serving
Calories: 168
Calories from Fat: 41
Watch how to make baked corn muffins stuffed with leftover BBQ pork.
See how to make amazing cornbread muffins.
See how to make an incredible muffin stuffed with fresh crabmeat.


text:
A 70-year-old Vancouver man who was found seriously injured in his home on East 6th Avenue near Brunswick Street in Vancouver early Sunday morning has died from his injuries.
Police have identified and are speaking with a person of interest in the case.
The Vancouver Police Major Crime Section is continuing the investigation.
CLICK HERE to view photographs related to this story, or if using a handheld device, tap the image above and swipe.
The biggest sale of the year, on now! Find almost $4 million worth of items such as cars, trips, furniture, gift cards and more at discounts of up to 50% off. Don't miss out as savvy shoppers will move fast to take advantage of these deep discounts. Sale ends Wednesday, April 1, at 9 p.m. Like it? Buy it before its gone. Brought to you by The Vancouver Sun and The Province.


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Is Samsung stealing Apple's thunder?
Samsung releases its S6 before Apple begins its process of hyping up its most recent Smartphone releaseMarch 23, 2015 2:24
Register for our free newsletter
Abu Dhabi Airports CEO leaving to take up U.K. defence ministry role
Kuwait February inflation edges up to 2.9 pct
MIDEAST STOCKS-Gulf markets sink after Yemen intervention; Dubai worst hit
HSBC's Islamic banking unit plans sukuk sale in Malaysia
Oil rises more than 1 pct, boosted by weaker dollar
UAE's Shah gas project seen achieving full capacity in Q2
National Bank of Fujairah issues 500 mln dirham tier 1 capital
Dubai builder Arabtec wins $283 mln contract from Saudi Aramco
Gold holds 4-day rally on softer dollar, U.S. rate hopes
Oil rises more than 1 pct, boosted by weaker dollar
The economic crisis seems to have done us one good service: The region is finally putting its financial houses in order.
February 1, 2011 4:45 by Sam Potter
It's not easy to see the silver lining of a global financial downturn, particularly living in a place that's been hit as hard as Dubai has. But being an occasionally upbeat sort of website, Kipp is doing its best, and we think we may have found an upside to the recession: the UAE's murky financial waters are finally clearing.
And better yet, people's attitudes are changing. Papers this week are reporting that financial companies in the UAE informed the Central Bank of 55 percent more suspicious money transfers in 2010 when compared with 2009. The head of the regulator's anti-money laundering unit says the Central Bank received 2,711 tip-offs from insurers, banks, investment companies and other financial services companies; there were just 1,750 in 2009.
Abdulrahim Mohamed al Awadi, an executive director of the Central Bank and the head of the anti-money laundering and suspicious cases unit says the rise "shows the effectiveness" of efforts to educate companies about their responsibilities. Hmm. Maybe. But the obvious question goes begging: Does this mean that there was more reporting of fraudulent activity, or simply that there was more fraudulent activity?
2009 was, of course, a year from hell in financial terms, so it wouldn't surprise us if fraudulent activity fell off – after all, pretty much all activity fell off. But 2010 wasn't a stellar year either, so a 55 percent raise in naughtiness seems pretty high. Kipp thinks its more likely that large finance operations, having been badly burned by the crisis, have realized that it's in their interests to shine a light into the murkier activities within their own businesses. Previously they may have turned a blind eye as everyone was happily making money, but when things get tight you learn something – it's far better to play it straight and know where all your money is.
So companies have learnt a valuable lesson. That's a good start. And as we have reported before, authorities and the markets have learned a few to. Such as: failing to match international standards is fine as long as everyone is making money, but when things turn bad the money will go where the standards are highest. The Dubai Financial Market gave us another glimpse of that this week as it announced the introduction of 'Short-Selling' and 'Securities Borrowing and Lending' later this year. It's also planning a new 'Delivery versus Payment' settlement mechanism to be instigated before the end of March. That's a more efficient and less riskier system of payment, basically.
Pages: 1 2
Picture this
February 1 2011
Homeward bound
February 1 2011


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The Top 10 Guys Women Fantasize About Cheating With
If you are male, married or otherwise indisposed with the fairer sex and wonder who your girlfriend or wife is cheating on you with in her mind, here's the list.
If you are male, married or otherwise indisposed with the fairer sex and wonder who your girlfriend or wife is cheating on you with in her mind, here's the list.
It's tempting to apply for all those store credit cards during the Holiday Season, but they tend to have very high interest rates. Fortunately, a new study says that there are four store credit cards that aren't going to rip you off!
A new study ranked the 87 most popular dog breeds based on things like cost, intelligence, health, and lifespan. Can you guess which dog breed was voted the best?
According to a new survey, the number one thing women wish men were better at is cleaning up around the house. Men wish women were better at is sex. Here is the complete list...
Thirteen years after the attacks on the United States by terrorists, many American don't feel safer. Will you change your routine today in lieu of threats made by ISIS?
My wife and I just celebrated our eight anniversary, so you would think by now we would have moved past our little food hang-ups. Evidently not.
All submarine jokes aside, did you know that the Department of the Navy announced that it will allow women to serve aboard some U.S. Submarines beginning in 2016. Is this a good idea?
It turns out, that the things that make us happiest in life, are the simple things...like ice cream!
Would You Rather Work With People You Like OR Get a Raise? Survey says...
Americans love their cars, they just don't necessarily love other Americans in cars.


text:
"We figured out that that program was a great situation for Taylor," Jean said.
Jean had no reservations about sending Taylor off to live with a host family like so many Canadian prospects do at that age.
"He's very independent," she said. "He was a kid who would go to camp for six weeks and he'd be all right."
Aronson was quite all right on the ice. A 6-foot, 196-pounder who models his game after Brian Rafalski of the Detroit Red Wings, Aronson had five goals and 25 assists in 71 games.
Those aren't gaudy numbers, but Aronson made himself known with his skating. He is ranked 88th among North American skaters by the NHL's Central Scouting Service.
"If he probably scored more, he'd be higher," said E.J. McGuire, NHL central scouting director.
"Usually statistics grab your eye, but 30 points in 71 games in this major junior league is pretty darn good. He's got good composure and he passes well."
Aronson also grades well off the ice. L.A. Junior Kings coach Jack Bowkus said the quiet and reserved Aronson is "a kid you want in your dressing room."
Johnston said Ducks and Kings personnel have been to Portland to scout Aronson, who said he has spoken with the Ducks.
No matter who picks him, Aronson will still be in disbelief. He never thought it possible to grow up in Southern California and get drafted, and the local angle of this weekend also makes it special.
"Not very many kids get the draft in their hometown when they're draft eligible," he said.
Aronson actually wouldn't be the first Placentia product to get drafted. T.J. Miller was chosen by New Jersey in 2006, and Aronson says he owes a debt of gratitude to players like him.
"You see all these (local) guys getting drafted and you think you have a chance," Aronson said. "They're paving the way for us."
Related posts:
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2XU Womens Compression Tights - Road Bike Shop
Road Bike Shop
Product Search Results For "2XU Women's Compression Tights" - (show more like this)
|2XU 3/4 Compression Tight - Women's
Race-day jitters can be unnerving enough. You don't need to be worrying about whether your legs can hold up to the extra abuse that comes with competition. The 2XU Women's jQuery1507342798916940926_1298664581442-Compression Tights support your muscles and reduce vibrations so that you can push...
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If you grew up with a mom who wore jeans a size or two too small in order to keep her girlish figure well into post-pregnancy middle age, then you might've decided that her method was too similar to medieval torture methods. Riding your bike to stay fit is a far better solution. The 2XU Recovery...
|2XU Women's Compression Tights
Just as you'll down a glass of First Endurance Ultragen immediately after a hard ride to maximize your recovery, right after you shower you'll be laying the groundwork for soreness-free training tomorrow by slipping on the 2XU Women's Compression Tights. Some folks wear them for an hour or two....
Price: $109.95


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Carle Place, NY 11514
$1350 -
0-2 Beds
1 Baths
Carle Place,
300 units |
0-2 Beds |
1 Baths
Current Rent Specials
(516) 874-2041
Westbury, NY 11590
$2560 -
1-3 Beds
1-2 Baths
Pets OK
396 units |
1-3 Beds |
1-2 Baths
(516) 874-2604
Garden City, NY 11530
$2715 -
1-3 Beds
1-2 Baths
No Pets
Garden City,
204 units |
1-3 Beds |
1-2 Baths
(516) 874-2042
Mineola, NY 11501
$1576 -
1-2 Beds
1-2 Baths
Pets OK
36 units |
1-2 Beds |
1-2 Baths
(631) 206-6577
$1850 -
0-2 Beds
1-2 Baths
Pets OK
80 units |
0-2 Beds |
1-2 Baths
(203) 202-8764
$1500 -
1-2 Beds
1 Baths
Pets OK
316 units |
1-2 Beds |
1 Baths
(631) 813-4508
Hempstead, NY 11550
$2518 -
0-3 Beds
1-2 Baths
Pets OK
166 units |
0-3 Beds |
1-2 Baths
(631) 813-4511
$ Email for details
1-3 Beds
1 Baths
Cats OK
212 units |
1-3 Beds |
1 Baths
$1900 -
Jericho Gardens,
(Jericho Gardens, West Jericho)
242 units |
1-3 Beds |
1-2 Baths
(516) 240-1105
East Meadow, NY 11554
$2420 -
2-4 Beds
1-2 Baths
Pets OK
East Meadow,
250 units |
2-4 Beds |
1-2 Baths
(516) 686-9326
West Hempstead, NY 11552
$2288 -
1-3 Beds
1-2 Baths
West Hempstead,
150 units |
1-3 Beds |
1-2 Baths
(631) 813-4509
$1470 -
0-2 Beds
1 Baths
Pets OK
80 units |
0-2 Beds |
1 Baths
(516) 247-6727
Hicksville, NY 11801
$1475 -
417 units |
1-2 Beds |
1 Baths
(516) 962-2361
Levittown, NY 11756
$1650 -
82 units |
1-2 Beds |
1 Baths
(516) 362-3449
Great Neck, NY 11021
$2995 -
1 Beds
1 Baths
Pets OK
Great Neck,
94 units |
1 Beds |
1 Baths
(516) 535-0056
Rockville Centre, NY 11570
$2680 -
Rockville Centre,
349 units |
1-2 Beds |
1-2 Baths
(516) 821-0876
Freeport, NY 11520
$1375 -
1-2 Bed
1 Bath
Stearns Park,
(Stearns Park)
1-2 Bed |
1 Bath
(516) 688-3764
Port Washington, NY 11050
$1680 -
0-3 Beds
1 Baths
Cats OK
Port Washington,
310 units |
0-3 Beds |
1 Baths
(203) 202-3180
Douglaston, NY 11363
$1400 -
0-2 Beds
1-2 Baths
(Douglaston, Little Neck...)
148 units |
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1-2 Baths
(718) 924-2851
Glen Cove, NY 11542
2 Beds
1 Baths
No Pets
Glen Cove,
19 units |
2 Beds |
1 Baths
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''Carle Place is a city where many who grew up here move back,'' as stated by Long Island News Day. The estimated 5,000 residents of Carle Place enjoy the tight knit community here, making it a great place to raise a family.
Carle Place is part of Nassau County, located approximately three miles North of Hempstead, NY and about 19 miles outside of Manhattan. With household value and income reported above average, anyone looking for Carle Place apartments to rent are sure to enjoy the small town atmosphere conveniently located 40 minutes outside of the Big Apple.
Residents of Carle Place have a number of nearby colleges and universities to choose from, including Adelphi University, American Academy of Dramatic Arts, and Hofstra University. Carle Place is located near John F. Kennedy Airport, making it a convenient location for men and women who travel for business.
New York State recognized Polar USA, which produces physical performance tools, as one of the top companies to work for in Nassau County in 2011. Other employment opportunities in Nassau County and the larger state of New York can be found on Nassau County's government page.
Residents can learn about local history by visiting the African American Museum and Carnegie Hall. For families and friends who love spending time outdoors, Belmont Lake State Park, the George Washington State Bridge, and the Bronx Zoo are in close proximity to Carle Place, making it easy to plan a day trip filled with outdoor adventures. Animal lovers will also enjoy spending time at the Cold Spring Harbor Fish Hatchery and Aquarium.
Local shoppers enjoy a variety of big name brands and unique shops located in and around Carle Place. From well known businesses like T.J. Maxx and DSW to San Giorgio Florist and Garden, locals and visitors are bound to find something that fits their needs. Still can't find exactly what you're looking for? Residents have the option to travel into the neighboring towns of Queen County or NYC to finish up any shopping left to do.
Local restaurants that have locals coming back for more include Rialto restaurant, West End Cafe, Koiso Japanese Restaurant, LL Dent Restaurant, and Vincent's Clam Bar. No matter what you're craving, local cuisines are sure to satisfy every food palate.
Rent.com® can help you get settled in a Carle Place apartment. Look through our rental listings and find the perfect home for your needs.
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60MHz Oscilloscope Probe Kit
Ideal for oscilloscopes and other portable instruments.
For the basic testing I do, this is an outstanding test probe made of excellent materials.
I am an electronics hobbiest experimenting with different basic circuits designs (e.g., amps, oscillators, logic, etc.). The basic circuits I am working with are less than 1 mhz, and my goal is to assure any square waves are not distorted through the circuitry. This test probe is excellent for this kind of testing.
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76-074 - 50ohm Insulated BNC Cable
Insulated male to male BNC cable assembly to IEC1010 standards 50ohm impedance. Black insulation boot. 40" length.
21-605 - BNC to Alligator Clips
Length 39''
21-8225 - Desoldering Pump - ESD Version
Provides safe, low cost means of desoldering connections, PC boards and components. Large capacity spring-loaded plunger quickly removes solder in a single action. Tools easily disassemble for fast cleaning, tip and "O" ring replacement. Intern...
MCM Cat 57, Page 1253
MCM Cat 56, Page 1088
Requires Adobe Acrobat Reader.
We are small group of performing musicians on a tight budget. MCM products have worked very well for us. Always looking for more live sound deals.