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Wolf Homburger The former Assistant Director of ITS Berkeley and the author of a widely used textbook on traffic engineering, died June 9, 2010. He was 83. Homburger joined ITS in 1955 as a junior research engineer. By the time he officially retired in 1990 he was the Institute's assistant director, and his popular classes along with his textbook, Fundamentals of Traffic Engineering, now in its sixteenth printing, had influenced thousands of students and transportation professionals. He combined teaching with a diverse research agenda, lecturing in countries around the world. In 1997, the Institute of Transportation Engineers, a national professional organization, honored him with the Wilbur S. Smith Distinguished Transportation Educator Award. The award recognizes those who have made an outstanding contribution to the transportation profession by relating academic studies to the actual practice of transportation. Homburger was born in Karlsruhe, Germany in 1926. In 1939, at age 12, he was sent to England as part of the last Kindertransport. He spent the war years living with a British family on a farm and attending school at Eastbourne College. He remained in close touch with that family and other school friends and professional colleagues for the rest of his life. As a young man he immigrated to the United States where he was finally reunited with his parents in New York City. He received a Bachelor's degree in Civil Engineering from The Cooper Union in 1950, and a Master's of Science in Civil Engineering from UC Berkeley in 1951. He was naturalized in 1951 and served in the U.S. Army Corps of Engineers from 1951 to 1955. Homburger met his late wife, Arlene at a UC Berkeley International House alumni event. They were married in 1958. Both had great affection for I-House and were generous supporters: Homburger's former resident room, 760, was dedicated in his honor in 2006, while its south patio was named in memory of his late wife. The couple were passionate about music, the arts, and committed supporters of Neve Shalom-Wahat al-Salam, a village in Israel where Jewish and Arab families live together in a peace-building effort. Homburger is survived by his son, Paul, and daughter-in-law, Donna, his daughter, Joanna, and son-in-law Britton Snipes, and five grandchildren, Julian, Chris, Heather, Meghan, and Brianna. A memorial will be held Sunday, June 27 at 2 p.m. in the Auditorium at International House.
Published in San Francisco Chronicle on June 24, 2010
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Finlayson egg producer fined $95,000 for manure spills
ST. PAUL -- Luoma Egg Ranch, an egg producer near Finlayson, was fined $95,000 by state pollution regulators Tuesday for violations stemming from chicken manure spills.
Luoma failed to report and attempted to cover up the liquid manure discharges from its egg-laying operation, the Minnesota Pollution Control Agency said. The company also improperly disposed of dead chickens.
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New Priest for Grace Episcopal
Community Contributed
By Nita Bogart
When Father Robert Walden received his calling to become an Episcopal priest, it was not a subtle nudge. He had served in the Air Force for 12 years and seemed settled in this career path. He had served in the Pacific, and was at Hickham Air force base in Hawaii, when one day, he had to go to Tripler Hospital to get medicine for his wife's heart condition. While there, he paid a visit to a friend who was a patient.
The visit had a powerful impact on him, and left him with an inspiration to become a priest.…


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The glomerular endothelial glycocalyx is postulated to be an important modulator of permeability and inflammation. The glycocalyx consists of complex polysaccharides, the main functional constituent of which, heparan sulfate (HS), is synthesized and modified by multiple enzymes. The N-deacetylase-N-
BACKGROUND AND OBJECTIVES: ESRD is accompanied by endothelial dysfunction. Because the endothelial glycocalyx (endothelial surface layer) governs interactions between flowing blood and the vessel wall, perturbation could influence disease progression. This study used a novel noninvasive sidestream-d
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations affecting different tissues. A characteristic feature of SLE is the presence of autoantibodies against double-stranded (ds)DNA, histones and nucleosomes, and other chromatin components. SLE is a
Proteinuria is a hallmark of many glomerular diseases and an independent risk factor for the progression of renal failure. Proteinuria results from damage to the glomerular filtration barrier (GFB), which plays a critical role in size- and charge-selective filtration. The GFB consists of three layer
Chemokines comprise a family of secreted proteins that activate G protein-coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by the binding of chemokines t
BACKGROUND: Levels of urinary biomarkers, such as kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL), can determine the risk of renal damage and predict the outcome of multiple kidney diseases, including transplant rejection. Studies of urinary biomarkers frequent
Slit diaphragm and podocyte damage is crucial in the pathogenesis of proteinuria in diabetic nephropathy (DNP). Gain-of-function mutations in TRPC6, a slit diaphragm-associated ion channel, cause glomerulosclerosis; TRPC6 expression is increased in acquired glomerular disease. Hyperglycemia and high
Renal involvement is a major medical concern in the diabetic population, and with the global epidemic of diabetes, diabetic nephropathy (DN) became the leading cause of end-stage renal failure in the Western world. Heparanase (the only known mammalian endoglycosidase that cleaves heparan sulfate) is
BACKGROUND: Activating mutations in the Transient Receptor Potential channel C6 (TRPC6) cause autosomal dominant focal segmental glomerular sclerosis (FSGS). TRPC6 expression is upregulated in renal biopsies of patients with idiopathic membranous glomerulopathy (iMN) and animal models thereof. In iM
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WarBack to homepage
Jade Helm 15 Is a False Flag Takedown the Power Grid In Order to Quell All Resistance
In recent months, both North Korea and Iran have threatened to launch separate EMP attacks upon the United States. Is such an attack likely? Would a foreign entity dare to launch such an attack given the threats made byRead More
Russia warns Denmark its warships could become nuclear targets
Russia tells Denmark not to join Nato missile shield or face becoming a target for Russian missiles By Julian Isherwood Russia has gone on the offensive in the Baltic, warning Denmark that if it joins Nato's missile defence shield, itsRead More
Are the Elite Going Into Hiding Because World War III Has Finally Begun?
Has World War III possibly begun? Have the elite and the key personnel in the intelligence agencies who provide information for the elite taken action to protect themselves from what is coming? This article examines a string ofRead More
US Combat Forces, FBI and CIA in Ukraine
By Stephen Lendman Global Research Obama continues using Kiev junta proxies to wage war on Donbass. He's gone all-out to sabotage multiple peace efforts spearheaded by Russia. He didn't wage war to quit. He's supplying Kiev with heavy weapons,Read More
Putin Targeted for Assassination-Will This Mean WW III or Russian Civil War?
Many in the independent media are proclaiming that a massive coup, which includes security personnel, top military leaders and top Russian businessmen, led by Russian Defense Minister Sergey Shoygu is intent on removing Putin and restoring relations with the West. I wish these reportsRead More
UPDATE: Details About Putin Emerging: Is Russia Moving Towards Civil War OR WORLD WAR III?
UPDATE: PUTIN ALLEGEDLY RESURFACES "The Russian president ordered nearly 40,000 troops in northern and western Russia to be put on full alert early Monday as part of snap-readiness exercise". Putin has not offered an explanation. The account of his resurfacing seem genuine.Read More
Russia's Seven-Pronged Strategy Designed to Conquer America
According to my sources, when Russian led and backed forces attack the United States, the attack will come as the result of a six-pronged strategy. 1. The Alaskan Front will see the Russians attacking the lower 48 from AlaskaRead More
It Is Now Possible to Predict When Putin Will Attack the United States
German leader, Angela Merkel is saying all the right things as she professes to be attempting to shore up western unity with regard to the crisis in Ukraine. However, Merkel is caught between a rock and a hard place.Read More
Dead Bankers Hold the Key to the Coming Civil War
Last year, 48 prominent bankers died in the most interesting case of coincidental deaths or one of the most daring plots against the elite in modern history. In THEmost amazing of these assassinations, 57-year-old Richard Talley was foundRead More
Russian Propaganda Is Turning Into Russian Assassination
To my friends and colleagues in the independent media, we need to continue to stand tall as more of us continue to be under attack in the media. To my fellow Americans who have come to depend on the independentRead More
World War III Will Begin In Syria
I am under attack by elements of the state-run Russian media (military). I am not alone. Anyone who dares to expose Russian military preparations for World War III, is under attack as I have discovered. Some of usRead More
Who Is Ultimately Behind the Mass Death and Destruction Coming to America?
I never would have believed that I would see the events of today's world racing towards Armageddon in the truest and Biblical sense of the term/place. However, where humanity is at is undeniable. Putin has been placed, byRead More
30 Reasons Proving That Putin Is Preparing to Start World War III
I frequently hear the following: Russia is a Christian nation. Putin is good Christian man. Russia only wants to defend its borders. Putin is the only obstacle between the New World Order and the people of the world. Stop,Read More
The Outrageous Way Obama Became President
How does a man get elected President after serving less than one full term as a U.S. Senator? Does being a community activist/antagonist qualify one for the highest office in the land? Were the Soviet defectors correct in that ObamaRead More
The Grand Chessboard of World War III
After the economic collapse, what comes next? Answer: The grand chess board of World War III! This article is not for the faint of heart. If one desires to keep on burying their head in the sand, then go watch theRead More


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"My hygienist told me about a new type of night guard that is available. Millie checked with my insurance company, and it will be covered. I have an appointment next week to have one made for me! Thanks! - Jul 24, 2013"Although virtually everyone appreciates the beauty of a nice smile, many people underestimate the importance of caring for that smile. Oral health problems tend to be progressive. The best solution is to prevent them entirely. If that is not possible, early detection and treatment is the next best option. This allows us to stop the condition from progressing and restore oral health with the most conservative techniques possible. The sooner you see a dentist the better – but never think it is too late. With good habits and good dental care, you can have the healthy, beautiful smile you deserve.
Ann A. (August 28, 2014)
Ann A. (August 28, 2014)
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We offer a number of solutions to stop oral disease in its tracks or – better yet – stop it before it starts. Regular dental visits and daily oral hygiene are the cornerstones of maintaining oral health. However, we each have unique dental care needs. Some of the most common options to prevent or correct oral health problems include:
- Periodontal therapy – Gum disease is a common condition, especially in older adults. It is the number one cause of adult tooth loss, and it has been linked to many serious health conditions. We offer scaling and planing, and other nonsurgical gum therapy.
- Root canal therapy – Contrary to common misconceptions, root canal treatment is gentle and effective, with minimal discomfort. It is needed when the soft tissue, called pulp, becomes injured or infected. The canal is cleaned, sterilized, and filled to prevent reinfection. Often, the tooth is crowned to protect it from damage.
- Fillings – Tooth decay may begin as a tiny cavity, but it spreads until it is treated. It can be corrected by removing the compromised portion of the tooth and filling the cavity with a biocompatible dental material.
- Night guards – Bruxism (clenching or grinding of your teeth, especially during sleep) can cause damage to dental work and jaw pain as well as wear and tear or fractures in your teeth. A comfortable, convenient, custom-made oral appliance can absorb the pressure, protecting your smile and your jaws.
- Extractions – Thanks to modern dental techniques, we can often repair and preserve unhealthy teeth. However, if the damage or disease is too severe, the tooth may not be savable. In this case, a gentle extraction is the best solution. We always recommend grafting in conjunction with extractions, to preserve your jawbone, keeping a strong foundation for a dental implant.
Let the dedicated, caring team at Aesthetic Smile Design help you restore and protect your oral health. Call us at (862) 766-6363 and schedule an appointment today.
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"I always receive thorough treatment, an explanation of what work was done, as well as what needs to be done. Recently I had a dental emergency, and Dr. Edeer responded quickly. Additionally, I am always given advice as to how to be proactive in my own care. The staff is always very pleasant and understanding. I definitely recommend Aesthetic Smile Design."
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<< Back - 2000 > Nissan > Maxima > Suspension > Sway Bar Link
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On this time I ordered several products for the suspension of my Nissan Maxima and as always I found the best quality,price and service from PartsGeek. This was the 4 or 5th time that I bought parts from them.
April 17th, 2014 | Posted by Gus


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Gas Stove for Fake Fireplace?
Hey everyone, my apartment was built in 1930 and has a fake fireplace. I believe what was in there before was a small gas heater of some kind. It probably gave off some heat and the gas line is still there, but there is nothing else there now.
What I'd really like to do is to put a gas stove in that space that is really more like a heater (though it looks like a stove). It would have to be zero clearance, and direct vent (for safety reasons). It would probably have to be relatively small as well. Does anyone have any recommendations?
I don't really care about the gas logs and flame stuff. It's fine if it's included but I'd almost rather just have an old fashioned looking gas stove/heater style in there. Any help would be appreciated. Thanks!
If you truly have a "fake fireplace" then you cannot use it to install ANYTHING including gas logs or a gas insert. It would need to be torn out and you would have to install either a gas fireplace or a freestanding gas stove. Don't take it literally when it says "zero clearance". Everything needs some kind of clearance.
You need to have a tech from a stove shop come out and take a look at the situation before you can even see what choices you may or may not have.
I used a freestanding gas stove as the sole source of heat in my home and I loved it. Many people thought it was burning wood it looked so realistic.
Okay, I'm reviving this because I still have the same question/issue. Yes, I realize that I would have to tear up the fake fireplace (in some way)to put it in a gas stove, but that's no big deal, just time or money.
But I certainly can't find a "stove shop" in Long Beach, California. Heck, I've never even heard of one. This would just be the main heater for the apartment for the 60 or so days a year that you'd want to have some extra warmth. Speaking of which, what I'd REALLY like is a stove that is also an air conditioner, but I'm pretty sure those haven't been invented yet. ;-)


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Sprinkle the shallot over the bottom of a skillet just large enough to hold the salmon in a single layer.
Place the salmon over the shallots and pour the hot stock into the pan.
Cover with foil, seal tightly, and cook over medium heat for 5 to 8 minutes, or until the salmon is cooked but not dry.
Check for doneness after 5 minutes.
Dram the fish, cover, and refrigerate until cold.
Bring 4 quarts of water to a rolling boil.
Trim the asparagus into 3-inch spears (reserve the ends for stock) and boil them for 2 to 3 minutes.
Drain the asparagus and plunge it into a bowl of ice water to stop the cooking and preserve the color, Drain, pat dry, and chill,


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Woooo hooooooo!! I knitted a triangle! :)
OK, I'm a novice, and my knitting up to now has involved flat items only -- baby blanket and scarves -- some with really nice designs, but still, just squares and rectangles. So yesterday I started on the multidirectional diagonal scarf (see pattern link below, or do an image google on the name for photos). It begins with knitting a triangle, and before it was even 2" long, I was holding it up for DH and saying, "Look! It's a triangle!" You'd think I'd invented the wheel! :) He was appropriately supportive and enthusiastic about it.
Then I got into the "short rows" part of the pattern, and that really got me going -- needless to say, I worked like crazy on it and am through one skein of yarn already, and it's turning out very cool.
Probably silly to get so darned excited over a scarf but like I said, I'm a novice, so learning anything new is a huge thrill!
Next stop: socks! That should really have me jumping up and down! :)
Here is a link that might be useful: multidirectional diagonal scarf
Congratulations Carol Ann! You SHOULD be excited to learn new techniques! And you have a right to be proud of yourself. Good for hubby for giving you the right reaction, too. Sometimes I want to kick myself by putting something off because it intimidates me, only to find that it wasn't as hard as I thought it was going to be.
You go girl!
Thanks, Donna... it *is* fun learning new things. I was so excited about the triangle, but when I got to the short rows I didn't see how it was going to work and I almost despaired... I didn't get how it would all knit together. Then I decided to just plunge in and follow the directions and see what happened, and gee, big surprise, it all worked out great! :) (Not only that, but it's a very easy pattern). You're right -- it's easy to let things intimidate but it pays to wade right in! Next stop: Sockville! :)
PS And big hugs to DH, who really is applauding my work, he's great for my ego! :)


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- Prison Planet.com - http://www.prisonplanet.com -
Obama won't rule out US boots on the ground in Syria
Posted By admin On May 4, 2013 @ 4:34 am In Tile,World News | Comments Disabled
Julian Pecquet
The Hill [1]
May 4, 2013
President Obama did not rule out sending U.S. troops to Syria on Friday but said he did "not foresee" such a scenario if his administration confirms that Bashar Assad's regime has used chemical weapons.
"As a general rule, I don't rule things out as commander-in-chief, because circumstances change. You want to make sure I always have the full power of the United States at our disposal to meet American national security interests," Obama said during a press conference in Costa Rica. "Having said that, I do not foresee a scenario in which American boots on the ground in Syria would not only be good for America but also be good for Syria."
He said the regional leaders who want to see Assad gone "agree with that assessment."
The president added that if his administration confirms that Assad's regime crossed his "red line" by using chemical weapons, he would take the case for action to the United Nations.
Article printed from Prison Planet.com: http://www.prisonplanet.com
URL to article: http://www.prisonplanet.com/obama-wont-rule-out-us-boots-on-the-ground-in-syria.html
URLs in this post:
[1] The Hill: http://thehill.com/blogs/global-affairs/middle-east-north-africa/297755-obama-wont-rule-out-boots-on-the-ground-in-syria
[2] Obama's Syria Attack Resolution Authorizes Boots on the Ground: http://www.prisonplanet.com/obamas-syria-attack-resolution-authorizes-boots-on-the-ground.html
[3] Kaine: Syria resolution must explicitly forbid boots on the ground: http://www.prisonplanet.com/kaine-syria-resolution-must-explicitly-forbid-boots-on-the-ground.html
[4] US Prepares 60,000 Ground Troops For Post-Assad Syria: http://www.prisonplanet.com/us-prepares-60000-ground-troops-for-post-assad-syria.html
[5] Kerry: US Ground Troops Could be Used in Syria: http://www.prisonplanet.com/kerry-us-ground-troops-could-be-used-in-syria.html
[6] Airdrop to Islamic State is Propaganda Ploy for Boots on the Ground in Syria: http://www.prisonplanet.com/airdrop-to-islamic-state-is-propaganda-ploy-for-boots-on-the-ground-in-syria.html
Click here to print.
Copyright © 2013 PrisonPlanet.com. All rights reserved.


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Are you Yoshio Yamamoto?Claim your profile
Publications (34)65.44 Total impact
Article: Sympathetic regulation of vascular tone via noradrenaline and serotonin in the rat carotid body as revealed by intracellular calcium imaging[Show abstract] [Hide abstract]
ABSTRACT: Hypoxia-induced chemosensory activity in the carotid body (CB) may be enhanced by the sympathetic regulation of vascular tone in the CB. In the present study, we recorded cervical sympathetic nerve activity in rats exposed to hypoxia, and examined noradrenaline (NA)- and serotonin (5-HT)-induced intracellular Ca2+ ([Ca2+]i) responses in smooth muscle cells and pericytes in isolated blood vessels from the CB. Multifiber electrical activity recorded from the cervical sympathetic trunk was increased during the inhalation of hypoxic gas. NA induced [Ca2+]i increases in smooth muscle cells in arteriole specimens, whereas 5-HT did not cause any [Ca2+]i responses. However, NA did not induce [Ca2+]i increases in pericytes in capillaries, whereas 5-HT did and this response was inhibited by the 5-HT2 receptor antagonist, ketanserin. In conclusion, cervical sympathetic nerves enhanced by hypoxia may reduce blood flow in the CB in order to increase chemosensitivity. Thus, hypoxic chemosensitivity in the CB may involve a positive feedback mechanism via sympathetic nerves.Brain Research 11/2014; DOI:10.1016/j.brainres.2014.11.037 · 2.83 Impact Factor
Article: Sympathetic and sensory innervation of small intensely fluorescent (SIF) cells in rat superior cervical ganglion[Show abstract] [Hide abstract]
ABSTRACT: The sympathetic ganglion contains small intensely fluorescent (SIF) cells derived from the neural crest. We morphologically characterize SIF cells and focus on their relationship with ganglionic cells, preganglionic nerve fibers and sensory nerve endings. SIF cells stained intensely for tyrosine hydroxylase (TH), with a few cells also being immunoreactive for dopamine β-hydroxylase (DBH). Vesicular acetylcholine transporter (VAChT)-immunoreactive puncta were distributed around some clusters of SIF cells, whereas some SIF cells closely abutted DBH-immunoreactive ganglionic cells. SIF cells contained bassoon-immunoreactive products beneath the cell membrane at the attachments and on opposite sites to the ganglionic cells. Ganglion neurons and SIF cells were immunoreactive to dopamine D2 receptors. Immunohistochemistry for P2X3 revealed ramified nerve endings with P2X3 immunoreactivity around SIF cells. Triple-labeling for P2X3, TH and VAChT allowed the classification of SIF cells into three types based on their innervation: (1) with only VAChT-immunoreactive puncta, (2) with only P2X3-immunoreactive nerve endings, (3) with both P2X3-immunoreactive nerve endings and VAChT-immunoreactive puncta. The results of retrograde tracing with fast blue dye indicated that most of these nerve endings originated from the petrosal ganglion. Thus, SIF cells in the superior cervical ganglion are innervated by preganglionic fibers and glossopharyngeal sensory nerve endings and can be classified into three types. SIF cells might modulate sympathetic activity in the superior cervical ganglion.Cell and Tissue Research 11/2014; 359(2). DOI:10.1007/s00441-014-2051-1 · 3.33 Impact Factor
Article: Immunohistochemical studies for the neuronal elements in the vomeronasal organ of the one-humped camel.[Show abstract] [Hide abstract]
ABSTRACT: The neuronal elements of the vomeronasal organ (VNO) of camel were investigated immunohistochemically. PGP 9.5 labeled the receptor cells in the vomeronasal sensory epithelium, but not the supporting or basal cells. OMP stained some receptor cells, but no immunoreactive signals for OMP were detected in the non-sensory epithelium. PLCβ2 labeled scattered cells in the sensory epithelium and a larger number of cells in the non-sensory epithelium. Double labeling immunohistochemistry revealed that the PLCβ2-positive cells were surrounded by substance P-positive nerve fibers. Collectively, these data suggest that the camel VNO bears, in addition to the mature vomeronasal receptor cells, trigeminally-innervated solitary chemosensory cells which are expected to play a substantial role in the control of stimulus access to the VNO.Journal of Veterinary Medical Science 10/2014; DOI:10.1292/jvms.14-0424 · 0.88 Impact Factor
Article: GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat[Show abstract] [Hide abstract]
ABSTRACT: We examined ATP-induced intracellular Ca2+ ([Ca2+]i) responses in the neurons and satellite cells from one of the viscerosensory ganglia, the nodose ganglion (NG), as well as the GABA-mediated modulation of ATP-induced neuronal [Ca2+]i responses using intracellular calcium imaging. In neurons with satellite cells, ATP induced [Ca2+]i increases in both the neurons and satellite cells. The P2X receptor agonist, α,β-meATP, induced [Ca2+]i increases in neurons and this response was inhibited by the P2X receptor antagonist, PPADS. On the other hand, the P2Y receptor agonist, ADP, induced [Ca2+]i increases in satellite cells, and this response was inhibited by the P2Y receptor antagonist, MRS2179. RT-PCR detected the expression of P2X2, P2X3, P2Y1, and P2Y2 receptor mRNAs in NG extracts. Immunohistochemistry revealed that NG neurons and satellite cells were immunoreactive to P2X2 and P2X3, and P2Y1 and P2Y2 receptors, respectively. In isolated neurons, the ATP-evoked [Ca2+]i increase was inhibited by GABA. However, in neurons with satellite cells, the GABAA receptor antagonist, bicuculline, enhanced the ATP-induced [Ca2+]i increase in neurons. These results suggest that viscerosensory neuronal excitability may be modulated by GABA from satellite cells in NG.Neuroscience Letters 10/2014; 584. DOI:10.1016/j.neulet.2014.10.008 · 2.06 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: In this study, immunohistochemical analysis has been performed using neuronal markers (GAP43, NCAM and PGP 9.5) to characterize the epithelial invagination in the medial wall of the olfactory pit in the chick embryos. At stages 26-27, the epithelial invagination was primarily composed of characteristic round-shaped cells, which were negative for neuronal markers. These cells were also found in the medial wall of the olfactory pit at stage 24, whereas the epithelial invagination was not observed at any stages other than stages 26-27. The possible relationship between the round-shaped cells and the migratory cells is discussed.Journal of Veterinary Medical Science 09/2014; 77(1). DOI:10.1292/jvms.14-0234 · 0.88 Impact Factor
Article: Vesicular glutamate transporter 2-immunoreactive afferent nerve terminals in the carotid body of the rat[Show abstract] [Hide abstract]
ABSTRACT: The carotid body is a peripheral chemoreceptor that detects decreases in arterial pO2 and subsequently activates the carotid sinus nerve. The hypoxia-evoked activity of the carotid sinus nerve has been suggested to be modulated by glutamate. In the present study, we investigate the immunohistochemical localization of vesicular glutamate transporters in the carotid body of the rat. Vesicular glutamate transporter 2 (VGLUT2) labeling was closely associated with glomus cells immunoreactive to tyrosine hydroxylase but was not in the cytoplasm of these cells. The VGLUT2 immunoreactivity was observed within nerve endings that were immunoreactive to P2X3 and densely localized inside P2X3-immunoreactive axon terminals. These results suggest that VGLUT2 is localized in the afferent nerve terminals of the carotid body. Glutamate may be released from afferent nerve terminals to modulate the chemosensory activity of the carotid body.Cell and Tissue Research 06/2014; 358(1). DOI:10.1007/s00441-014-1921-x · 3.33 Impact Factor
Article: Histological and Lectin Histochemical Studies on the Olfactory and Respiratory Mucosae of the Sheep[Show abstract] [Hide abstract]
ABSTRACT: The olfactory and respiratory mucosae of the Corriedale sheep were examined using lectin histochemistry in order to clarify the histochemical and glycohistochemical differences between these two tissues. The olfactory epithelium was stained with 13 lectins out of 21 lectins examined, while the respiratory epithelium was positive to 16 lectins. The free border of both of the olfactory and respiratory epithelia was stained with 12 lectins: Wheat germ agglutinin (WGA), succinylated-wheat germ agglutinin (s-WGA), Lycopersicon esculentum lectin (LEL), Solanum tuberosum lectin (STL), Datura stramonium lectin (DSL), Soybean agglutinin (SBA), Bandeiraea simplicifolia lectin-I (BSL-I), Ricinus communis agglutinin-I (RCA-120), Erythrina cristagalli lectin (ECL), Concanavalin A (Con A), Phaseolus vulgaris agglutinin-E (PHA-E) and Phaseolus vulgaris agglutinin-L (PHA-L). The associated glands of the olfactory mucosa, Bowman's glands, were stained with 13 lectins. While both the goblet cells and mucous nasal glands were stained with eight lectins; five of them (WGA, s-WGA, STL, Vicia villosa agglutinin (VVA) and ECL) were mutually positive among the Bowman's glands, mucous nasal glands and the goblet cells. These findings indicate that the glycohistochemical characteristics of the free borders of both olfactory and respiratory epithelia are similar to each other, suggesting that secretions from the Bowman's glands and those of the goblet cells and mucous nasal glands are partially exchanged between the surface of two epithelia to contribute the functions of the respiratory epithelium and the olfactory receptor cells, respectively.Journal of Veterinary Medical Science 11/2013; 76(3). DOI:10.1292/jvms.13-0436 · 0.88 Impact Factor
Article: Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat.[Show abstract] [Hide abstract]
ABSTRACT: It has been proposed that serotonin (5-HT) facilitates the chemosensory activity of the carotid body (CB). In the present study, we investigated mRNA expression and immunohistochemical localization of the 5-HT synthetic enzyme isoforms, tryptophan hydroxylase 1 (TPH1) and TPH2, and the 5-HT plasma membrane transport protein, 5-HT transporter (SERT), in the CB of the rat. RT-PCR analysis detected the expression of mRNA for TPH1 and SERT in extracts of the CB. Using immunohistochemistry, 5-HT immunoreactivity was observed in a few glomus cells. TPH1 and SERT immunoreactivities were observed in almost all glomus cells. SERT immunoreactivity was seen on nerve fibers with TPH1 immunoreactivity. SERT immunoreactivity was also observed in varicose nerve fibers immunoreactive for dopamine beta-hydroxylase, but not in nerve fibers immunoreactive for vesicular acetylcholine transporters or nerve terminals immunoreactive for P2X(3) purinoreceptors. These results suggest that 5-HT is synthesized and released from glomus cells and sympathetic nerve fibers in the CB of the rat, and that the chemosensory activity of the CB is regulated by 5-HT from glomus cells and sympathetic nerve fibers.Histochemie 12/2012; DOI:10.1007/s00418-012-1066-5 · 2.93 Impact Factor
Article: Short-term hypoxia increases phosphorylated tyrosine hydroxylase at Ser31 and Ser40 in rat carotid body.[Show abstract] [Hide abstract]
ABSTRACT: Long-term hypoxia (days to weeks) increases phosphorylation of tyrosine hydroxylase (TH) at Ser31 and Ser40 in the carotid body (CB). In the present study, we examined the time course of TH phosphorylation at Ser31 and Ser40 in CB of rats exposed to short-term hypoxia (within 1 day) for 0-24h. Using immunoblotting, the signal intensities of both phosphorylated TH were more intense in CB of rats exposed to hypoxia for 6, 12, 18, and 24h than those of controls. Using immunohistochemistry, immunoreactive intensities of both phosphorylated TH were significantly more intense in glomus cells after rats were exposed to hypoxia for 6, 12, 18, and 24h than those of controls (p<0.05). These results show that phosphorylation of TH at Ser31 and Ser40 is increased in CB glomus cells by short-term hypoxia, suggesting that activation of TH via phosphorylation contributes to the facilitation of catecholamine biosynthesis in CB glomus cells at an early stage of hypoxia.Respiratory Physiology & Neurobiology 11/2012; DOI:10.1016/j.resp.2012.11.004 · 1.97 Impact Factor
Article: Short-term Hypoxia Transiently Increases Dopamine B-Hydroxylase Immunoreactivity in Glomus Cells of Rat Carotid Body.[Show abstract] [Hide abstract]
ABSTRACT: Under long-term hypoxia, noradrenaline (NA) content in the carotid body (CB) increases, suggesting that NA plays an important role in CB chemotransduction. However, it is unknown whether short-term hypoxia upregulates NA biosynthesis in CB. Therefore, we examined dopamine β-hydroxylase (DBH) expression in the CB of rats exposed to hypoxia (10% O2) for 0 to 24 hr with immunoblotting and immunohistochemistry. Using immunoblotting, the signal intensity for DBH appeared to be the most intense in rats exposed to hypoxia for 12 hr. Using immunohistochemistry, DBH immunoreactivity was observed in the cytoplasm of some glomus cells and varicosities in controls and rats exposed to hypoxia for 6 hr. In rats exposed to hypoxia for 12 hr, DBH immunoreactive intensities in DBH-positive glomus cells were significantly higher compared with controls (p<0.05). In the CB of rats exposed to hypoxia for 18 and 24 hr, DBH immunoreactive intensities in DBH-positive glomus cells were significantly lower than that of rats exposed to hypoxia for 12 hr (p<0.05). These results demonstrate that DBH immunoreactivity is transiently increased in glomus cells by short-term hypoxia, suggesting that NA biosynthesis is transiently facilitated in glomus cells at an early stage of hypoxia.Journal of Histochemistry and Cytochemistry 09/2012; DOI:10.1369/0022155412464639 · 2.40 Impact Factor
Article: Increased total volume and dopamine β-hydroxylase immunoreactivity of carotid body in spontaneously hypertensive rats.[Show abstract] [Hide abstract]
ABSTRACT: Under hypertension, it has been reported that the carotid body (CB) is enlarged and noradrenaline (NA) content in CB is increased. Therefore, it is hypothesized that morphological and neurochemical changes in CB are induced in hypertensive animal models. In the present study, we examined the morphological features and dopamine β-hydroxylase (DBH) immunoreactivity in CB of spontaneously hypertensive rats (SHR/Izm) and Wistar Kyoto rats (WKY/Izm). The CB of SHR/Izm was elongated in terms of the cross section of center and was enlarged in the reconstructed images compared with that of WKY/Izm, and the total volume of CB in SHR/Izm (0.048 ± 0.004 mm³) was significantly (p<0.05) increased compared with the value in WKY/Izm (0.032 ± 0.006 mm³). By immunohistochemistry, immunoreactivity for tyrosine hydroxylase in CB was mainly observed in glomus cells and the immunostaining properties were similar between WKY/Izm and SHR/Izm. On the other hand, DBH immunoreactivity was mainly observed in nerve fibers around blood vessels and observed in a few glomus cells in CB of WKY/Izm. The number of glomus cells with strong DBH immunoreactivity was increased in SHR/Izm compared with that in WKY/Izm. In conclusion, the present study exhibited the enlargement of CB as three-dimensional image and revealed the enhanced immunoreactivity for DBH of glomus cells in SHR/Izm. These results suggest that the morphology of CB is affected by the effect of sympathetic nerve and that the signal transduction from CB is regulated by NA in glomus cells under hypertensive conditions.Autonomic neuroscience: basic & clinical 04/2012; 169(1):49-55. DOI:10.1016/j.autneu.2012.03.005 · 1.82 Impact Factor
Article: Morphology and chemical characteristics of subepithelial laminar nerve endings in the rat epiglottic mucosa.[Show abstract] [Hide abstract]
ABSTRACT: The laminar nerve endings are distributed in the laryngeal mucosa, and described as sensory receptors evoked by laryngeal pressure changes. The present study aimed to determine detailed morphological characteristics of the laryngeal laminar endings of the rat. Immunohistochemistry for Na(+)-K(+)-ATPase, α(3) subunit, showed that laminar endings were distributed in the entire laryngeal surface of the epiglottis. The parent axons of the endings were thick in diameter, and they were branched and continued to the endings. In some cases, several endings from different parent axons fused into a large complex structure of 500 μm in width. The laminar endings were also immunoreactive for vesicular glutamate transporter 1 (vGLUT1) and vGLUT2, but not for P2X(3) purinoceptor. Around the laminar endings, terminal Schwann cells with immunoreactivity for S-100 protein were closely associated with axon terminals. Use of scanning electron microscopy with alkaline maceration method showed that the terminal Schwann cells consisted of a rounded perinuclear region and lamellar cytoplasmic processes. Ultrastructurally, axon terminals with numerous mitochondria were partly covered with Schwann cell sheath, and some terminals intruded into the epithelial layer. Clear vesicles of 50 nm in diameter were also observed especially in small cytoplasmic processes of 400 nm to 1 μm in size. The results in the present study suggested that the laminar endings in epiglottic mucosa have morphological characteristics of slowly adapting mechanoreceptors and contribute to sensation of laryngeal pressure via mucosal tension.Histochemie 03/2012; 138(1):25-39. DOI:10.1007/s00418-012-0939-y · 2.93 Impact Factor
Article: Submucosal mast cells in the gastrointestinal tract are a target of staphylococcal enterotoxin type A.[Show abstract] [Hide abstract]
ABSTRACT: Staphylococcal enterotoxin A (SEA) is a leading causative toxin of staphylococcal food poisoning. However, it remains unclear how this toxin induces emesis in humans, primates, and certain experimental animals. To understand the mechanism of SEA-induced emesis, we investigated the behavior of SEA in the gastrointestinal (GI) tract in vivo using the house musk shrew (Suncus murinus). Immunofluorescence of GI sections showed that perorally administered SEA translocated from the lumen to the interior tissues of the GI tract and rapidly accumulated in certain submucosa cells. These SEA-binding cells in the submucosa were both tryptase- and FcεRIα-positive, suggesting these SEA-binding cells were mast cells. These SEA-binding mast cells were 5-hydroxytryptamine (5-HT)-positive, but the intensity of the 5-HT signal decreased over time compared to that of mast cells in the negative control. Furthermore, toluidine blue staining showed the number of metachromatic mast cells was decreased in the duodenal submucosa, suggesting that SEA binding induced degranulation and release of 5-HT from submucosal mast cells. These observations suggest that the target cells of SEA are submucosal mast cells in the GI tract and that 5-HT released from submucosal mast cells plays an important role in SEA-induced emesis.FEMS Immunology & Medical Microbiology 12/2011; 64(3):392-402. DOI:10.1111/j.1574-695X.2011.00924.x · 2.68 Impact Factor
Article: Developmental Changes in Lectin-Binding Patterns of Three Nasal Sensory Epithelia in Xenopus laevis[Show abstract] [Hide abstract]
ABSTRACT: The nasal cavity of adult Xenopus laevis (X. laevis) is composed of a series of three compartments: principal, middle, and inferior chambers. The principal chamber is lined with olfactory epithelium (OE), middle chamber with middle chamber epithelium (MCE), and inferior chamber with vomeronasal epithelium (VNE). In the present study, we examined developmental changes of lectin-binding patterns of the OE, MCE, and VNE by the use of four biotinylated lectins; DSL, DBA, PNA, and UEA-I. From Stage 59, just after the beginning of metamorphosis, the stainings of the free border for DBA and UEA-I were decreased in the OE and MCE, respectively, but the stainings of secretory granules (SGs) in the OE became intense. From Stage 63, sensory cells positive for DSL were increased in these three epithelia, and positive stainings for UEA-I and DBA increased in the SGs and Jacobson's glands (JGs), respectively. In addition, from 3 months after the end of metamorphosis, the stainings of sensory cells for PNA, DBA, and DSL changed in the OE, MCE, and VNE, respectively, and those of the SGs, Bowman's glands, and JGs also changed for several lectins. The present results showed that glycoconjugates expressed in three epithelia and their associated glands changed during and after the end of metamorphosis. These findings may indicate that the functional maturation of each epithelium depends not only on the maturation of sensory cells, but also on the maturation of the SGs in supporting cells of the OE and their associated glands after the end of metamorphosis.The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 05/2011; 294(5):839-46. DOI:10.1002/ar.21377 · 1.34 Impact Factor
Article: Morphological Development and Expression of Neurotrophin Receptors in the Laryngeal Sensory Corpuscles[Show abstract] [Hide abstract]
ABSTRACT: Morphological development of sensory structures in the laryngeal mucosa of postnatal rats was observed by use of immunohistochemistry for protein gene-product 9.5 (PGP9.5). Moreover, expression changes of high affinity neurotrophin receptors, TrkA, TrkB and TrkC, and low affinity neurotrophin receptor p75(NTR) were examined to elucidate the relationship to morphogenesis. Intraepithelial nerve endings and parent axons of the laminar endings with immunoreactivity for PGP9.5 have already appeared in the rat on embryonic day 18 (E18) as well as solitary chemoreceptor cells in the glottic cleft. According to neurotrophin receptors, TrkA immunoreactivity were observed on and after postnatal week 3 (3W) in the nervous sensory structures, that is, free nerve endings, laminar endings and sub- and intragemmal plexuses of the taste buds. In the laminar endings, TrkC immunoreactivity was also observed on and after 3W. According to the laryngeal sensory cells, the solitary chemoreceptor cells were immunoreactive to TrkA, TrkB, and TrkC on and after postnatal day 3 (P3). In the taste buds in arytenoid region, taste cells were immunoreactive for TrkA, TrkB, and TrkC on and after 3W, P14, and 3W, respectively. Immunoreactivity for p75(NTR) was observed on the surface of taste cells on and after P9. The results of the present study suggest that sensory structures in the laryngeal mucosa were developed on perinatal days to involve respiratory reflex, and that neurotrophin receptors may take part in the regulation and maintenance of sensory structures.The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 04/2011; 294(4):694-705. DOI:10.1002/ar.21344 · 1.34 Impact Factor
Article: Morphological characteristics and peptidergic innervation in the carotid body of spontaneously hypertensive rats.[Show abstract] [Hide abstract]
ABSTRACT: We examined morphological characteristics of the carotid body of spontaneously hypertensive rats (SHR), those of age-matched normotensive Wistar rats (NWR), and age-matched genetically comparable Wistar Kyoto rats (WKY). We examined the distribution and abundance of four different regulatory neuropeptides: substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), and neuropeptide Y (NPY) in the carotid bodies of these three strains of rats. The carotid bodies of SHR were larger than those of NWR and WKY. The values of the long axis of the carotid bodies of SHR were significantly larger (1.3 times) than those of NWR and WKY. In the carotid bodies of SHR, the percentage of relatively large vessels was similar to that of the carotid bodies of WKY, although the carotid bodies themselves were significantly larger than in WKY. The density of VIP varicose fibers in the carotid bodies of SHR was lower than in the carotid bodies of WKY, although the density of SP, CGRP and NPY fibers was similar to that of the carotid bodies of NWR and WKY. These findings suggested that VIP was unrelated to enlargement of the carotid body of SHR, but it might modify the sensitivity of chemoreceptors in the carotid body.Histology and histopathology 03/2011; 26(3):369-75. · 2.24 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Nitric oxide (NO) is a free radical and produced from L-arginine by nitric oxide synthase (NOS). Since NO is recently suggested to be involved in olfactory perception, the expression of eNOS, an isoform of NOS, was examined in the rat olfactory epithelium. The activity of NADPH-diaphorase was also examined as a marker of NOS. In the dorsomedial region of the nasal cavity, intensely positive reactions for NADPH-diaphorase were observed in the entire cytoplasm of sensory cells (olfactory cells). By immunohistochemistry, intensely positive reactions for eNOS were also found in the dorsomedial region of the nasal cavity. These reactions were observed on the free border of the olfactory epithelium. By immunoelectron microscopy, positive reactions for eNOS were found in the cilia of olfactory cells. In addition, in situ hybridization analysis of the olfactory epithelium revealed the expression of eNOS mRNA in the olfactory cells. These results indicate the presence of eNOS in the olfactory cells of the rat, and differential expression of eNOS in the olfactory epithelium depending on the regions of the nasal cavity. In addition, NO produced by eNOS may be involved in olfactory perception in the cilia of olfactory cells.Journal of Veterinary Medical Science 11/2010; 73(4):423-30. DOI:10.1292/jvms.10-0353 · 0.88 Impact Factor
Article: Lectin histochemical studies on the olfactory epithelium and vomeronasal organ in the Japanese striped snake, Elaphe quadrivirgata.[Show abstract] [Hide abstract]
ABSTRACT: The olfactory epithelium and the vomeronasal organ of the Japanese striped snake were examined by lectin histochemistry. Of the 21 lectins used in the study, all lectins except succinylated-wheat germ agglutinin (s-WGA) showed similar binding patterns in the vomeronasal receptor cells and the olfactory receptor cells with varying intensities. The binding patterns of s-WGA varied among individuals in the vomeronasal and olfactory receptor cells, respectively. Four lectins, Bandeiraea simplicifolia lectin-II (BSL-II), Dolichos biflorus agglutinin (DBA), Sophora japonica agglutinin (SJA), and Erythrina cristagalli lectin (ECL) stained secretory granules and the organelles in the olfactory supporting cells and did not stain them in the vomeronasal supporting cells. These results suggest that the glycoconjugate moieties are similar in the vomeronasal and olfactory receptor cells of the Japanese striped snake.Journal of Morphology 10/2010; 271(10):1197-203. DOI:10.1002/jmor.10864 · 1.55 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Neurochemical and morphological changes in the carotid body are induced by chronic hypoxia, leading to regulation of ventilation. In this study, we examined the time courses of changes in immunohistochemical intensity for tyrosine hydroxylase (TH) and cellular volume of glomus cells in rats exposed to hypoxia (10% O(2)) for up to 24 hr. Grayscale intensity for TH immunofluorescence was significantly increased in rats exposed to hypoxia for 12, 18, and 24 hr compared with control rats (p<0.05). The transectional area of glomus cells was not significantly different between experimental groups. The TH fluorescence intensity of the glomus cells exhibited a strong negative correlation with the transectional area in control rats (Spearman's rho = -0.70). This correlation coefficient decreased with exposure time, and it was lowest for the rats exposed to hypoxia for 18 hr (rho = -0.18). The histogram of TH fluorescence intensity showed a single peak in control rats. The peaks were gradually shifted to the right and became less pronounced in hypoxia-exposed rats, suggesting that a hypoxia-induced increase in TH immunoreactivity occurred uniformly in glomus cells. In conclusion, this study demonstrates that short-term hypoxia induces an increase in TH protein expression in rat carotid body glomus cells.Journal of Histochemistry and Cytochemistry 09/2010; 58(9):839-46. DOI:10.1369/jhc.2010.956250 · 2.40 Impact Factor
Article: Differences in tyrosine hydroxylase expression after short-term hypoxia, hypercapnia or hypercapnic hypoxia in rat carotid body.[Show abstract] [Hide abstract]
ABSTRACT: In the carotid body (CB), it has been reported that the expressions of tyrosine hydroxylase (TH) mRNA and TH protein are enhanced by exposure to hypoxia. However, it is not known whether CO(2) affects the expression of TH in the CB. We examined the expression of TH mRNA and the immunoreactivity for TH in the CB of rats exposed to hypoxia (10% O(2)), hypercapnia (10% CO(2)) and hypercapnic hypoxia (10% O(2) and 10% CO(2)) for 2-24 h. The expression of TH mRNA in the CB was markedly enhanced in rats exposed to hypoxia for 4 h (6.6-fold), 6 h (6.0-fold) and 8 h (7.8-fold), and in rats exposed to hypercapnic hypoxia for 12 h (4.8-fold). The most intense TH immunoreactivity was observed in the CB from rats exposed to hypoxia for 12 and 24 h and to hypercapnic hypoxia for 24 h. The expressions of TH mRNA and the immunoreactivity for TH were not altered in the CB of rats exposed to hypercapnia. It is suggested that CO(2) does not affect TH expression in the CB, and that it inhibits hypoxia-enhanced TH expression.Respiratory Physiology & Neurobiology 08/2010; 173(1):95-100. DOI:10.1016/j.resp.2010.07.003 · 1.97 Impact Factor
Top Journals
Iwate University
Morioka, Iwate, Japan
- Faculty of Agriculture
Ehime University
Matuyama, Ehime, Japan
- Faculty of Medicine


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|November 1, 2012 02:00 PM EDT
ARM TechCon2012- Pioneering the use of the ARM 64-bit architecture to deliver unprecedented server innovation, AppliedMicro Circuits Corporation (NASDAQ:AMCC) will today for the first time demonstrate several open source software applications running on its X-Gene™ Server on a Chip™ platform, the world's first implementation of the 64-bit ARMv8 architecture.
In a session co-hosted by ARM and AppliedMicro at ARM TechCon™ 2012, AppliedMicro plans to demonstrate advanced web search capabilities and the ability to handle big data workloads in an Apache™ Hadoop™ software environment. The company will showcase ARM 64-bit server software ecosystem readiness with American Megatrends, Phoenix, Red Hat, and several other open source software components. The session will include presentations from operating system developer, Red Hat; virtualization solution provider, Citrix; enterprise Hadoop software and solutions provider, Cloudera; Java platform provider, Oracle; and an enterprise cloud computing technologist from Morgan Stanley. The session will take place from 11 a.m. – 12:30 p.m. in the Hands-on Lab located in the main exhibit hall of the Santa Clara Convention Center.
"Our activities today highlight the significant progress that is being made in building out the ARM 64-bit ecosystem, a process that is on track to perfectly intersect with the availability of our X-Gene silicon," said Dr. Paramesh Gopi, president and CEO of AppliedMicro. "We see strong pull from data center and enterprise administrators who require lower power, higher densities and lower total-cost-of-ownership. Together with ARM and the open source software community, AppliedMicro is revolutionizing server design, and showing what is possible with a purpose-built server platform."
The AppliedMicroX-Gene Server on a Chip platform offers unparalleled integration, featuring multi-core ARMv8-compliant 64-bit processors, a high performance memory subsystem, cloud server I/O with integrated Ethernet NIC, and other communications interfaces – all on a single chip. Capable of running a full LAMP software stack and other cloud software applications, the X-Gene platform can be implemented in data centers to dramatically drive down total cost of ownership (TCO).
In a separate announcement last week, AppliedMicro, ARM and Red Hat announced that Red Hat is actively engaged in developing support within the Fedora community for the new 64-bit ARMv8 architecture, also known as AArch64, and has Fedora Linux running on AppliedMicro hardware in its labs. Red Hat aims to have software support at the time of the X-Gene silicon availability.
About AppliedMicro
AppliedMicro is a global leader in energy conscious computing solutions for public and enterprise clouds, telco, enterprise embedded applications, data center, consumer and SMB applications. With a heritage of innovation in high-speed connectivity and high-performance computing, AppliedMicro delivers silicon solutions that dramatically lower total cost of ownership for service provider and data center infrastructures. AppliedMicro's corporate headquarters are located in Sunnyvale, California. Sales and engineering offices are located throughout the world. For further information regarding AppliedMicro, visit the company's Web site at http://www.apm.com.
X-Gene, Server on a Chip, Applied Micro Circuits Corporation, AMCC, AppliedMicro and the AppliedMicro logo are trademarks or registered trademarks of Applied Micro Circuits Corporation. All other product or service names are the property of their respective owners.
SYS-CON Events announced today that robomq.io will exhibit at SYS-CON's @ThingsExpo, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. robomq.io is an interoperable and composable platform that connects any device to any application. It helps systems integrators and the solution providers build new and innovative products and service for industries requiring monitoring or intelligence from devices and sensors.
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The 17th International Cloud Expo has announced that its Call for Papers is open. 17th International Cloud Expo, to be held November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, APM, APIs, Microservices, Security, Big Data, Internet of Things, DevOps and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit your speaking proposal today!
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While not quite mainstream yet, WebRTC is starting to gain ground with Carriers, Enterprises and Independent Software Vendors (ISV's) alike. WebRTC makes it easy for developers to add audio and video communications into their applications by using Web browsers as their platform. But like any market, every customer engagement has unique requirements, as well as constraints. And of course, one size does not fit all. In her session at WebRTC Summit, Dr. Natasha Tamaskar, Vice President, Head of Cloud and Mobile Strategy at GENBAND, will explore what is needed to take a real time communications ...
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As Marc Andreessen says software is eating the world. Everything is rapidly moving toward being software-defined – from our phones and cars through our washing machines to the datacenter. However, there are larger challenges when implementing software defined on a larger scale - when building software defined infrastructure. In his session at 16th Cloud Expo, Boyan Ivanov, CEO of StorPool, will provide some practical insights on what, how and why when implementing "software-defined" in the datacenter.
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SYS-CON Events announced today that Solgenia will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY, and the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Solgenia is the global market leader in Cloud Collaboration and Cloud Infrastructure software solutions. Designed to "Bridge the Gap" between Personal and Professional Social, Mobile and Cloud user experiences, our solutions help large and medium-sized organizations dr...
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Internet of Things (IoT) will be a hybrid ecosystem of diverse devices and sensors collaborating with operational and enterprise systems to create the next big application. In their session at @ThingsExpo, Bramh Gupta, founder and CEO of robomq.io, and Fred Yatzeck, principal architect leading product development at robomq.io, will discuss how choosing the right middleware and integration strategy from the get-go will enable IoT solution developers to adapt and grow with the industry, while at the same time reduce Time to Market (TTM) by using plug and play capabilities offered by a robust I...
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The world's leading Cloud event, Cloud Expo has launched Microservices Journal on the SYS-CON.com portal, featuring over 19,000 original articles, news stories, features, and blog entries. DevOps Journal is focused on this critical enterprise IT topic in the world of cloud computing. Microservices Journal offers top articles, news stories, and blog posts from the world's well-known experts and guarantees better exposure for its authors than any other publication. Follow new article posts on Twitter at @MicroservicesE
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After making a doctor's appointment via your mobile device, you receive a calendar invite. The day of your appointment, you get a reminder with the doctor's location and contact information. As you enter the doctor's exam room, the medical team is equipped with the latest tablet containing your medical history – he or she makes real time updates to your medical file. At the end of your visit, you receive an electronic prescription to your preferred pharmacy and can schedule your next appointment.
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SYS-CON Events announced today the IoT Bootcamp – Jumpstart Your IoT Strategy, being held June 9–10, 2015, in conjunction with 16th Cloud Expo and Internet of @ThingsExpo at the Javits Center in New York City. This is your chance to jumpstart your IoT strategy. Combined with real-world scenarios and use cases, the IoT Bootcamp is not just based on presentations but includes hands-on demos and walkthroughs. We will introduce you to a variety of Do-It-Yourself IoT platforms including Arduino, Raspberry Pi, BeagleBone, Spark and Intel Edison. You will also get an overview of cloud technologies s...
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Containers and microservices have become topics of intense interest throughout the cloud developer and enterprise IT communities. Accordingly, attendees at the upcoming 16th Cloud Expo at the Javits Center in New York June 9-11 will find fresh new content in a new track called PaaS | Containers & Microservices Containers are not being considered for the first time by the cloud community, but a current era of re-consideration has pushed them to the top of the cloud agenda. With the launch of Docker's initial release in March of 2013, interest was revved up several notches. Then late last...
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The WebRTC Summit 2015 New York, to be held June 9-11, 2015, at the Javits Center in New York, NY, announces that its Call for Papers is open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 16th International Cloud Expo, @ThingsExpo, Big Data Expo, and DevOps Summit.
Apr. 1, 2015 09:00 AM EDT Reads: 1,771
SOA Software has changed its name to Akana. With roots in Web Services and SOA Governance, Akana has established itself as a leader in API Management and is expanding into cloud integration as an alternative to the traditional heavyweight enterprise service bus (ESB). The company recently announced that it achieved more than 90% year-over-year growth. As Akana, the company now addresses the evolution and diversification of SOA, unifying security, management, and DevOps across SOA, APIs, microservices, and more.
Apr. 1, 2015 08:30 AM EDT Reads: 2,143
The list of 'new paradigm' technologies that now surrounds us appears to be at an all time high. From cloud computing and Big Data analytics to Bring Your Own Device (BYOD) and the Internet of Things (IoT), today we have to deal with what the industry likes to call 'paradigm shifts' at every level of IT. This is disruption; of course, we understand that – change is almost always disruptive.
Mar. 30, 2015 04:00 PM EDT Reads: 1,228
SYS-CON Events announced today that SafeLogic has been named "Bag Sponsor" of SYS-CON's 16th International Cloud Expo® New York, which will take place June 9-11, 2015, at the Javits Center in New York City, NY. SafeLogic provides security products for applications in mobile and server/appliance environments. SafeLogic's flagship product CryptoComply is a FIPS 140-2 validated cryptographic engine designed to secure data on servers, workstations, appliances, mobile devices, and in the Cloud.
Mar. 30, 2015 11:00 AM EDT Reads: 1,594
GENBAND has announced that SageNet is leveraging the Nuvia platform to deliver Unified Communications as a Service (UCaaS) to its large base of retail and enterprise customers. Nuvia's cloud-based solution provides SageNet's customers with a full suite of business communications and collaboration tools. Two large national SageNet retail customers have recently signed up to deploy the Nuvia platform and the company will continue to sell the service to new and existing customers. Nuvia's capabilities include HD voice, video, multimedia messaging, mobility, conferencing, Web collaboration, deskt...
Mar. 30, 2015 01:00 AM EDT Reads: 1,562
SYS-CON Media announced today that @WebRTCSummit Blog, the largest WebRTC resource in the world, has been launched. @WebRTCSummit Blog offers top articles, news stories, and blog posts from the world's well-known experts and guarantees better exposure for its authors than any other publication. @WebRTCSummit Blog can be bookmarked ▸ Here @WebRTCSummit conference site can be bookmarked ▸ Here
Mar. 29, 2015 10:00 PM EDT Reads: 1,918
SYS-CON Events announced today that Cisco, the worldwide leader in IT that transforms how people connect, communicate and collaborate, has been named "Gold Sponsor" of SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. Cisco makes amazing things happen by connecting the unconnected. Cisco has shaped the future of the Internet by becoming the worldwide leader in transforming how people connect, communicate and collaborate. Cisco and our partners are building the platform for the Internet of Everything by connecting the...
Mar. 29, 2015 07:00 PM EDT Reads: 5,334
Temasys has announced senior management additions to its team. Joining are David Holloway as Vice President of Commercial and Nadine Yap as Vice President of Product. Over the past 12 months Temasys has doubled in size as it adds new customers and expands the development of its Skylink platform. Skylink leads the charge to move WebRTC, traditionally seen as a desktop, browser based technology, to become a ubiquitous web communications technology on web and mobile, as well as Internet of Things compatible devices.
Mar. 29, 2015 06:00 PM EDT Reads: 1,918


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In an unprecedented move, the Rajasthan Assembly in a unanimous decision on Thursday sentenced a woman police officer to 30 days rigorous imprisonment for breach of privilege. Circle Inspector Ratna Gupta refused to cooperate and behaved rudely with members of a House committee when, in July 2010, they paid a surprise visit to the Gandhi Nagar police station here that she was then heading.
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Kelly Macdonald
Brave Is Not One of Pixar's Greatest Hits: Review
Originally posted 06/26/2012 01:45PM
A lead character who's not all that likeable until the movie's almost over? Well now, that is brave. It's also not a terrific idea.
Merida (Kelly Macdonald) is petulant, snotty and irresponsible – in other words, a teenager. But the archery-loving Scottish princess also lacks empathy and is cruel to her fiercely traditional mother, Queen Elinor (Emma Thompson), and that's harder to swallow. Worse, though, is Brave's nutty central plot twist.
The spoiler-lite gist is that after visiting a witch (a kicky Julie Walters) in hopes of avoiding marriage to one of the dorky sons of a nearby clan, Merida leaves with a darkly magical charm that sends her on a life-altering quest.
Filed Under: Pixar, Brave, Movies, Emma Thompson, Julie Walters, Kelly Macdonald
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Chicago billboard sparks ire: 'Life's Short. Get a Divorce.'
pete41(9ab FL.)May 9, 2007
Makes sense to me-better than
``Stay miserable and prove what?lol
dublinbay z6 (KS)
Confirmed ex-married,
The sexy body pictures on that ad: Only frustrated married folks imagine that the single scene is filled with an unlimited number of eager sexy bodies available to the newly divorced. In actuality, most ex-married find it a very lonely world out there and can't wait to get married again. Well, keeps the lawyers busy anyway, I guess--which was what the ad was seeking.
Confirmed ex-married,


text: An Indo-Russian cultural programme will be held at the Mahajana First Grade College, Jayalakshmipuram in the city on Tuesday. The event, which will begin at 3 p.m., will feature various programmes by a visiting Russian team and is being organised as part of a cultural exchange programme. — Special Correspondent


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20 Crafts with Mason Jars: Wedding Ideas, Centerpieces, Dcor and More
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Paper Flower Centerpiece
By: Cara Mariano for Sizzix
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Delicate die-cut paper flowers replace silk flowers in these homemade wedding centerpieces from Sizzix. Jewels and pretty table numbers add additional flourish.
- Sizzix Originals Die 654980 Flower Layers #2
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- Vase
- Embroidery Thread
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Remove silk flower from the stems.
Die-cut flowers out of coordinating paper and use them to replace the silk flowers.
Arrange flower stems with sticks in a vase.
- Use thread to hang jewels and table numbers from the Flower stems.
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Conference blog: Where is Brian?
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I was proposing the Policy Motion on Cutting Crime in the main Liberal Democrat conference venue this afternoon here in Bournemouth. Where is Pink News?
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Company Blog
Looking forward to IAB MIXX
Next week, I have the distinct honor of hositng a breakout discussion at IAB MIXX. Joining me is an esteemed group of panelists pulled from all corners of the digiital media market. It promises to be an insightful and entertaining dialogue about the changing role of audience data and consumer insight in shaping today's digital content, commerce, and advertising experiences.
If you're at IAB MIXX next Monday, do drop in on our session.
Monday, October 3, 230p-315p
Room 510, 5th floor
Looking Beyond Data Management to Understand Digital Media's Consumer Experience Imperative
Explore the growing opportunity in consumer data from the perspective of both the web publisher and the advertiser/agency. This panel investigates:
- How web publishers, marketers, and agencies can equip themselves to bring data-driven audience advertising to market, with attention to the required investments in systems, processes, and people
- How privacy concerns, consumer choice, and data security inform the development of robust markets for data-driven advertising and commerce
- Which new business models, technologies, and usage patterns offer the highest promise for capturing new revenue from consumer data
Moderator: Tom Chavez, Co-Founder and Chief Executive Officer, Krux Digital
Michael Greene, Analyst, Forrester Research
Pam Horan, President, Online Publishers Association
Josh Jacobs, President, Accuen
Megan Pagliuca, General Manager, Display Media, Merkle
The MIXX event is being held at NYC's Crowne Plaze Hotel, Monday, October 3rd through Tuesday, October 4th.
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Everything installed perfectly the first time. CM11 ran nearly perfectly, especially considering it's a nightly and there are no stable releases or RCs, yet, etc.
On Thursday I spent a full day at my desk at work. I noticed that my phone rebooted in my pocket. I figured "hey, it's a nightly...I've seen far worse"....then I noticed almost every 2 hours it seemed to reboot again, sometimes more frequently. It never rebooted in the middle of me using it...only while in my pocket.
So, I figured "hey, no big deal. Another nightly or two and this should be ironed out." So I restored my stock backup on Friday after work. All weekend long, no problems whatsoever. I figured it must have been something wonky in the nightly CM11.
Then on Monday, while sitting at my desk, it happened again...and again....and again. Same exact circumstances. I figured maybe I borked something so I got a restore-to-stock and flashed it via Odin.
Well, long story short this continues to be a problem whenever I spend any significant time at my desk at work. It doesn't happen anywhere else so far. It happens with any ROM I throw at it. I've Googled around and it appears that I'm far from the only person experiencing this problem however I don't experience froot-loops like a lot of people. Just semi-random reboots.
Now, I'm pretty convinced that a different (or new) modem would take care of this. I had the GS2 on Sprint and we had a problem we referred to as "LOS" (Loss Of Service) which typically required a reboot...even on my bone-stock phone...it seems to happen with the same randomness. One thing I do know about sitting at my desk, my phone is constantly switching back and forth between H, H+, LTE, DC and occasionally E...Edge being the only thing that gets solid service about 1 wobbly bar.
That's my own theory. This isn't a deal breaker for me. It only happens at work and if I wait a few seconds my phone is back in commission without any intervention.
Anyone else have a similar experience, tips, ideas, theories...? I'm more curious than anything.


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Each year, beginning sometime in December and lasting until the end of March, a steady progression of whales choose to winter in Baja's warmer waters. During this time, a stroll along our beach will often afford you views of whale spouts, flukes, and perhaps even a full breach. Many a collective gasp has gone up in the yoga studio as the whales offshore put on a show while everyone in class is staring spellbound out to sea.
For a closer view, we offer the opportunity to take a tour from the Cabo marina out past the world-famous Cabo Arch to get a better look at the humpbacks as well as the occasional gray whale. You'll head out in a small, agile boat that's great for whale watching because it can quickly dart toward whale spouts spotted in the distance.
On a few occasions, we've even had guests get up-close-and-personal with a few humpback whales while out on the kayak and snorkel tour that we offer. Paddling alongside a momma and her calf makes for quite an exciting whale watching experience!
The grandeur of these majestic creatures is palpable as they gracefully glide through the deep blue waters transitioning between the Sea of Cortez and the Pacific Ocean. For anyone who has not been out on the ocean to witness these beautiful animals in their element, it is an experience that you are not likely to ever forget.
Prana del Mar is the ideal of what a retreat centre should be: comfortable, hospitable, beautiful, and tranquil. An ideal location for deepening your practice.Mike Bernard
My wife, Glory, and I have been to many yoga retreat centers all over the world, and Prana del Mar is by far the best all around.John Norton
Prana del Mar is an oasis in the Mexican desert. The facility – with its amazing attention to detail – is an extremely supportive environment in which to delve deeper into one's practice.Pam Johnson
I can't imagine a more perfect place for a yoga retreat! The yoga room is perfect – the mats, the blankets, the floor, the views, the candles – perfect. Our group bonded in a special way. I can't imagine a better vacation, and we will be back next year for sure.Holly Jordon
Prana del Mar is a beautiful space with an amazing staff that is genuinely happy that you are there to experience what they have to offer. Erik always has his door open if you need anything and is diligent in making sure you are having a good time. Very organized and awesome staff! I feel that I've …Betty Chen
This was a trip of a lifetime. I feel so blessed to have been able to experience this climate and yoga in your beautifully planned and executed wellness retreat. Your dream is so appreciated. We had an experience we will always remember.Kristen Downs
Prana Del Mar was the perfect location to host a yoga retreat. They have thought of everything! My guests appreciated the comfortable beds, the nice linens, the beautiful yoga room, the healthy and inventive cuisine, and – most of all – the hospitality of Erik and his staff. I have led many retreats…Leigh Threlkel
This place is truly an experience of serenity and magic. I was so relaxed – for the first time in a long time – I could feel the stress melt off me. This is not only an experience of peaceful yoga, delicious food, and beautiful nature, it is a safe and welcoming sanctuary of the most amicable people…Sarah Baughn
What a wonderful retreat center you have created. The combination of location, facilities, accommodations, and staff made for a fantastic overall experience. Thank you for all your hospitality.David Frechter
Prana Del Mar is a near-fantasy of polished travertine, elegant movement studio, healing and beautiful food, caring and talented staff, remote of the world, remote from your world, bringing you to a rare place left on the planet where you can hear the wind, feel the pounding surf, see the sun and th…Kathleen Conklin
I feel so fortunate to have had the opportunity to be a guest at Prana del Mar. The serene location, the exquisite property, the service, the decor, the yoga hall, the retreat, and Erik, all served to provide an outstanding and very special experience I will forever remember. Go. You will thank your…Xell Calderer
The facilities and service far exceeded my expectations. The food was perhaps the most delicious and fulfilling vegetarian cuisine I've ever eaten. A truly lovely experience.Cara Alter
Prana del Mar has been an amazing experience. From the facilities and people to the activities and resources provided, no detail was overlooked. Erik has done an incredible job creating this space for spiritual, physical, and mental rejuvenation. I hope to be lucky enough to return in the near futur…Tami Kim
Prana del Mar is a magical place that exceeded all my expectations. With two beautiful yoga studios, a stunning semi-private beach for walks or meditation and meals that were amazing in both taste and variety, I was in heaven. The staff were warm and generous, the pool deliciously cool in the heat o…Kirsten McFarlane
Prana del Mar is an exceptional retreat center in every way. Amazing rooms, well-equipped yoga studios, fantastic food, peaceful energy, and exceptional service. I have been leading retreats for many years; this is the best I can imagine. The attention to detail – from planning to the event itself –…Kay Taylor
Prana del Mar is truly a tiny chunk of nirvana. I was very impressed by the feeling of security that permeates this place. The staff was great – very helpful and welcoming. They truly enhance the peaceful, secure vibe, making it so easy to relax and let the yoga work its magic. The companionship I e…Janet Vanyo
Everything about the retreat and the place exceeded my expectations. I loved the idea of being surrounded by nature and taking a quick walk to the beach every day from my room. Everything about the place made me feel so comfortable and serene. It was quite delightful to witness the love and the care…Jae Yang
The sound of the ocean, the scent of delicious, organic food in the air, the feeling of being surrounded by mountains, water and desert…. Prana del Mar is steeped in natural beauty and a real delight for the senses. This is the perfect place to practice yoga, reconnect with nature, and completely un…Erin Teague
Thank you for creating such a peaceful, inspiring, caring place with such exceptionally positive energy. The attention to detail in the yoga space, rooms, and gardens has made Prana del Mar a true "oasis" of a retreat in this world of options. I'll look forward to returning.Lynne Bairstow
One word: transformative. Prana del Mar was the perfect setting for an experience that has been years in the making. We are blessed at Yoga Rasa with the teachings of Padma Shakti – and blessed to be here at Prana del Mar. Incredible scenery and service. And the food…Wow! Thank you so much.Susie Barry-Taylor
My stay at Prana del Mar was hands-down fantastic. I enjoyed every minute of my stay at the resort. The staff was very welcoming and accommodating. The food was great. I will definitely be back for another yoga retreat. So peaceful and wonderful!Julie Lubner
Divine. Every element of Prana del Mar radiates the care and awareness that has created this amazing retreat centre. The beauty of the facility's design and construction, the superbly prepared meals, the friendly staff and Erik's welcoming presence made our week beyond perfect. Prana del Mar is trul…Josephine Anderson
Prana del Mar far exceeds your expectations of an off-grid retreat haven. It felt like heaven to relax and be cared for so lovingly in such a beautiful place. The people and the food were completely outstanding and made us all feel so welcome. I will definitely be back.Heather Stewart
Staying at Prana del Mar was amazing. From the second I arrived and the kindness Erik showed, I felt like I was at a home away from home. All of the meals were delicious. The staff makes you feel so welcome and they were so helpful all the time. I can't wait until the next time I get to return.Sarah Choueiry
I just had to express once again how wonderful, incredible, and beautiful Prana del Mar is. Not just the physical structure – which was obviously built with painstaking care and loving vision – but the people, too. You and your staff made the week absolutely perfect. Thank you, thank you, thank you!…Karen Robins
The peaceful merging of wet and dry, hot and cold, silence and the crashing of waves, helped me to feel the peace of reconciling the opposites in my life. Thank you for the gifts of beauty, sweetness, delicious food, and the space to reflect and grow. Om Shanti.Ande Smith
Prana del Mar is a treasure of open space. The beach and ocean are vast, and the yoga studios spacious. Everywhere you look, there are vistas of muted greens and browns, desert brush, and sky. The rooms are above and beyond any rooms you'll find anywhere else.Carolyn Strom
With attention to detail and care for the visitors, this is a perfect place for a retreat – with the strength of the mountains and the ocean around us. An unforgettable yoga retreat. Congratulations to you and your team.Hélène Lévesque
Thank you for a wonderful experience. Your pride and commitment to the retreat centre is obvious. The food was fantastic and the staff were so friendly and considerate. There is a great sense of community, and I felt very much at home. I can't wait to come back.Laurie Poole
As close to perfect as you could hope to find for a yoga retreat center. Beautiful accommodations, mind-blowing location (particularly in whale season), and the most welcoming and attentive staff we have ever encountered.Jo Thornhill
I cannot believe a place like this exists on earth. The location and scenery is more majestic than any photo could capture. The night sky looks like a planetarium. The food is beyond belief at every meal. Every single staff member seems to go out of their way to make your experience perfect. Not eve…Rachel Weshnak
I have been to many yoga retreat centers and found Prana del Mar to have the nicest studios, most accommodating staff, deluxe facilities, and cleanest property. The food was a variety of cuisines with the healthiest and freshest ingredients – and always delicious.Lindy Bolero
We were taken care of on every level – with delicious food, comfortable and elegant rooms, magnificent ocean views, deep healing bodywork, and plenty of relaxing poolside. All of the arrangements for activities were handled seamlessly – from the moment we arrived, the relaxation began. Prana del Mar…Susan Rubin
Prana del Mar, an ecologically sound retreat centre, fulfilled its every promise to our group – with its tasteful and luxurious accommodations, its two beautiful yoga spaces, exceptional organic vegetarian cuisine, and its friendly and efficient staff whose attention to detail was much appreciated. …Patsy Watts
Prana del Mar is an exceptional facility – encouraging relaxation, contemplation, and growth. Our stay was a stellar experience.Beth Reid
I love Prana del Mar and I intend to return. The quiet of the desert is perfect for the Zen-nature of a retreat. The atmosphere is welcoming, warm, and simple. Plenty to do and see and plenty of space for contemplation, away from the business of ordinary life. The openness of the center gave me room…Gillian Clark
I travel all over the world on business. I feel that Prana del Mar does a great job of capturing the spirit of prana and quiet contemplation. Erik has an excellent crew, and the grounds are clean and nicely-appointed. The quiet ocean location reinforces the meditative atmosphere. Excellent!David Tuhy
Prana del Mar is a slice of heaven! It is the perfect place to relax, unwind, and be still. The staff is kind and attentive; the views exceptional. I enjoyed my stay so much that I'm already making plans to return!Julie Sullivan
Prana del Mar is a magical place. I would highly recommend it to anyone who wants a super-relaxing yoga vacation. A special gem of Mexico.Jenny Rios
Prana del Mar was everything we expected and more. The yoga studio and equipment were top-notch and no detail was left out. The accommodations were first-class right down to the organic linens, towels and toiletries. The view of the mountains, ocean and the sunsets were breathtaking. Erik and the st…Bill & Betsy Stringfellow
Congratulations on creating this oasis of extraordinary beauty and space. The staff are gracious and so accommodating. Delightful, truly. I hope and expect that I will visit Prana del Mar a number of times in my life!Maura Lynch
How could it get better than Prana? Not possible. Year 2 of our retreat and everyone here at Prana del Mar and everything here is even more magical than last year. The new studio is beautiful – the space lends itself beautifully to meditative practices and we used both studios to full advantage. The…Betsy Weiner
We had a wonderfully relaxing stay at Prana del Mar. The accommodations are clean, well-kept, and serene. The yoga rooms are well-designed and the view can't be beat. The wholesome meals are creative, nutritious, and delicious. This is my second visit to Prana del Mar and I will surely come back aga…Amy Hemmert
If you live a life that needs a break, Prana del Mar is the place to go. Sleep with the sound of waves – no intrusions from radio or TV. Vegetarian-based meals made so well that meat lovers really don't miss a thing. Walk beaches, watch the ocean and its ever-changing form. Do yoga, get a massage, a…Jan Matsumoto
Prana del Mar is an idyllic place for relaxation of mind, body, and soul. It has everything that is required to make one feel that life is perfect right here. From the endless desert surrounded by mountains to the intense power of the sea to the modern and pristine accommodations to the yoga studio "…Rhonda Travis
Prana del Mar is a space to unwind, relax, and nurture the soul. I am incredibly grateful to have been able to experience the serenity, to nurture my yoga practice, and to heal my body in this environment. The meals were created in such a personal way. I have honestly never had such healthful meals …Jennifer Rikkers
Everything was, as always, exceptional. Beautiful facility, excellent staff, wonderful food, beautiful views. Topped with perfect weather and exceptional yoga. It is the perfect destination.Nancy Agajeenian
My stay at Prana del Mar was incredible. It is a beautiful, relaxing place. I loved getting to unplug from life and have no distractions. It's like staying in a 4-star hotel without all the Hollywood scene. My stay has left me feeling relaxed and peaceful. Listening to the waves all night is magical…Ellen Schinkle
Prana del Mar is the perfect spot for your yoga retreat. The accommodations, food, yoga space, pool, and beach are excellent. The staff is extremely professional. It will exceed all your expectations.Sue Smith
After almost a decade of hosting retreats, we have found paradise. Prana del Mar is a haven for restoring the body, mind and soul. The beachfront location is pristine, the food is nourishing, and the attention to detail and respect for the environment make Prana del Mar the ideal location for retrea…Shani Cranston