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Women of The Daily Show to Jezebel: Go F@#k Yourself!
It turns out there are lots of them.READ MORE »
It turns out there are lots of them.READ MORE »
Chef Shames 'Insulting,' 'Entitled' Customers on Instagram After They Threaten Nasty Yelp Reviews
18 Women on What Contractions Really Feel Like
HBO's Scientology Exposé Going Clear Is Jaw-Dropping
That Time the Avengers Battled Scientology
Rare Photos of Frida Kahlo From the Last Years of Her Life
What It's Like to Be a Woman in a Field That's Still 99 Percent Male
When Is a Penis Too Good to Break Up With?
The Life and Crimes of Robert Durst: A Timeline
Saturday Night Live Recap: Dwayne 'The Rock' Johnson Is SNL Viagra
10 Women on Their Female Bosses

subset: commoncrawl


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Some students may be asked to complete a Personal Reflection Sheet. This exercise will encourage students to consider their academic goals, understand their strengths and recognize any obstacles they may need to overcome.
Personal Reflection Sheet
Please download, complete, and print the attached form.
Please download, complete, and print the attached form.
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- For First Year Students


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CDC Closes Anthrax, Flu Labs After Potentially Deadly Mix-Ups Come to Light 89
from the try-the-new-super-vaccine dept.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
The handling of deadly disease agents should be privatized and put into the hands of industry as soon as possible! Let the free market solve the problem!
> Employees not wearing protective gear worked with bacteria that were supposed to have been killed but may not have been.
So the employees didn't use protective gear during their work, and that got them slated for a killing? I can understand trying to contain an outbreak, but one would think they should have been quarantined and tested for infection before commencement with the killing. Who's in charge of this mickey mouse operation anyway?
% APL is a natural extension of assembler language programming; ...and is best for educational purposes. -- A. Perlis


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Break open that Liquid Advil to zap a ZIT! Aspirin has long been known as an in-a-pinch zit zapper--but technology has created pimple-fighter 2.0 thanks to liquid gel formulas. "I hear makeup artists use this all the time on models backstage at fashion shows," says beauty guru Robin Coe-Hutshing. "Open up an Advil gel cap and apply it right onto the pimple. Who knew?? Turquoise Necklaces, Colors Combos, Fashion, Statement Necklaces, Turquois Jewelry, Accessories, Gold Jewelry, Chunky Necklaces
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MAGIC............... style statement: "On matters of style, swim with the current, on matters of principle, stand like a rock." ― Thomas Jefferson
Stripes work year round! I'll add a clear necklace, dark jeans and a moto jacket to transition into fall.
Stephan & Co Cutout Cuff. $14 This is the kind of piece that pulls a boring outfit together and makes it look polished. It would be a great finishing touch with jeans, a fitted T, and flats.
#LaurenConrad's guide to wearing statement necklaces


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There is always a good amount of confusion and conflicting claims regarding heating service in Elizabethtown – specifically, confusion about heating bills and energy usage. In order to become more energy-efficient and cut down on your costs to keep warm during the winter, it's important that you separate fact from fiction and learn the truth about the best ways to keep warm while cutting costs. Following are some myths about heating energy and explanations for each:
Myth: Portable space heaters use up too much energy. Space heaters actually are a great option for homes that have small areas that need to be heated. While the mainRead More
These days, to have a truly comfortable home, you need to have an energy-efficient home. As a homeowner, you have quite a bit of control over just how efficient it is. Fortunately, there are steps you can take to maximize your efficiency and save as much energy and money as possible – the first step is starting with the right professional to service your A/C and heating repair in Elizabethtown.
Choose the right professional for the job. EC&S technicians are insured, certified and licensed. Our experts in furnace maintenance participate in continuing education courses to ensure our customers always receive the most advanced, thorough and updatedRead More
It's important for every homeowner to understand the basics of home heating systems for several reasons, including the fact that this knowledge can help cut service costs and keep units working efficiently for as long as possible. By understanding the basics and knowing some preventive actions you can take when it comes to furnace maintenance, you'll have a much more pleasant experience with your unit while enjoying lowered furnace repair service costs.
How do Home Heating Systems Work?
There are three basic components to these systems: a source of warmed air, a way to distributing the air to the rooms being heated, and a thermostat to regulateRead More


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Home : Brands : Supersmile : Supersmile Ultimate Whitening System
NewBeauty - Beauty Choice Award
The Best At-Home Tooth Whitening Kit
The Supersmile Ultimate Whitening System combines the Professional Activating Rods with Supersmile's best selling Whitening System - working in tandem to amplify whitening results for the ultimate white smile. The Ultimate Whitening System is not your average at-home whitening kit. The Professional Activating Rods mimic the first step in Dr. Smigel's in-office whitening procedure as they clean and prepare the surface of the tooth to allow the Professional Whitening System to work more efficiently and effectively. The Professional Whitening System removes stains above and below the enamel just by brushing for deeper whitening without sensitivity.
Kit Includes:
Professional Activating Rods: Use twice weekly prior to brushing for an extra whitening boost. Rub the Activating Rods across your teeth and leave on for 30 seconds. Do not rinse. Follow by brushing with the Professional Whitening System.
Professional Whitening System: On a dry toothbrush, combine a pearl-sized drop of Whitening Toothpaste and Whitening Accelerator. Brush with this Professional Whitening System for 2 minutes moving the brush in quick, tiny circles. Rinse with water. Continue use of the Professional Whitening System twice daily in place of your regular oral care routine.
This product can be shipped to any country to which SkinStore currently ships.
This product can only be shipped to addresses in the lower 48 US States. This product has been designated as Hazardous by the US Department of Transportation (DOT). The DOT prohibits air shipment of items that are pressurized, flammable or in any other way threaten an onboard fire or other mishap.
Restricted items include:
We're committed to getting your order to you as quickly as possible, but we must do so in compliance with DOT regulations. Therefore, we require ground-only delivery, at our Standard Shipping rate, for orders containing DOT-restricted products. Currently, ground transport deliveries are taking 5-7 days.
SkinStore cannot ship DOT-restricted items to Alaska, Hawaii, military, international addresses, or addresses serviced exclusively by air.


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Beyond embarrassing: The rise of 'Mortified Nation'
Much the way Jews have employed storytelling to mark their experience, the 'Mortified' franchise uses the musings of youth to preserve one's adolescence.
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Dave Nadelberg basically owes his career to a childhood crush. The Los Angeles-based 38-year-old is the creator and coproducer of Mortified, a wildly popular live storytelling series where adults read excerpts from their dusted-off diaries, songs and stories — all written during the messy throes of adolescence.
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Apple now building 2M iPads per month to meet demandApple has doubled its monthly output capacity of the iPad and is now manufacturing 2 million per month to meet strong consumer demand, but the company reportedly would like to go even further and produce 3 million every month very soon.
Analyst Katy Huberty with Morgan Stanley indicated that iPad builds recently increased to 2 million per month, up from the previous number of just 1 million a month. Apple allegedly indicated to its suppliers that it would like to produce 3 million a month starting in the fourth calendar quarter of 2010.
It's likely not coincidental that less than a week ago, iPad shipping times for new orders from apple.com improved to 24 hours. For months, customers had to wait an estimated 7 to 10 days, as Apple was surprised by strong demand for the device when it launched in April.
Officials with the company admitted they were initially caught off guard by the demand for the iPad after it launched, and they were unsure when they would be able to satisfy that demand. Chief Operating Officer Tim Cook noted that the iPad is not taking a typical early adopter curve, and already has a "very big" market.
"We want to take full advantage of it, and so we are investing enormous time and resources in increasing our capability in getting iPad out to as many people as we can," Cook said in July.
Despite strong demand, Huberty reiterated that the iPad has not cannibalized sales of Macs. She noted that U.S. Mac sales are tracking up 20 to 25 percent year over year, and have been accelerating in recent weeks.
In June, it was estimated that Apple was producing a total of 1.2 million iPads per month. That was up from 800,000-900,000 units in May, 700,000 units in April, 470,000 units in March, and 300,000 in February. At the time, it was projected that Apple could produce as many as 2.5 million per month in time for the 2010 holidays.
On Topic: iPad
- Microsoft ditches ARM for Intel with new $499 Surface 3, its latest iPad competitor
- Adobe debuts Comp CC for iPad, Facebook Messenger gets third-party hooks, Google Drive enables automatic backups
- Apple embarks on wave of new battery-related job hires, targets iOS improvements
- Rumor: Apple's jumbo 'iPad Pro' allegedly shown in spy shots with potential second port
- UK Parliament approves $1.5M plan to supply members with new iPad Air 2s, laptops


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Does anyone know how to delete a blog post?
I went into BlogHer '10 thinking about the recap I'd write AFTER it was all over, which sounds weird, doesn't it? It's true, though. I've been to five BlogHer Cons (plus BlogHer Food '09) and I work here, too. I know the scene. We come. We connect. We laugh. We cry. We learn. We get angry. We wear great shoes. We're overwhelmed. That stuff -- it's the same every year. This year, going into the conference, I was really tired before I ever landed in NYC.
Read more >
Don't worry, you're not seeing things, and you haven't wandered into the wrong site by accident. You are looking at the shiny, new BlogHer.com ...
Read more >
My son-in-law was released from the boat and came home to put the crib and dresser changing table combo thingy together. There's been a virtual baby shower and an in-real-life baby shower. Jenn is starting to complain a little bit because 36 weeks feels a whole lot more pregnant than 35 weeks. I'll be in Hawaii in a few weeks and Johnny Mac Pippin will be here soon and I'm back to saying, "OMG I'm Going to Be a Grandmother!" again.
It's also started to hit me that I don't exactly know what that means. Read more >
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Whether you're a Griswold fan or prefer the retro allure of Bedford Falls, there are certain movies that just make the holidays complete—but not all of them were always so popular. Here's what the critics originally thought of 10 of our favorite festive films.... READ ON
Listen to our new best friend LeVar Burton read "'Twas the Night Before Christmas" from the Reading Rainbow iPad app.... READ ON
You know Ralphie Parker's plight by heart. But can you spot A Christmas Story's flubs?... READ ON
Christmas through the years.... READ ON
111,111,111 x 111,111,111 = 12,345,678,987,654,321


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Women Dressed as Cops Arrested After Robberies
Two Los Angeles County women who committed robberies posing as police officers in Rancho Dominguez last week have... Watch »
Man Drops Pants, Dances in Intersection: Deputy
Deputies see it all in their line of work, but one deputy saw quite a bit more than she expected while at a major... Read »
Black Lab Takes Solo Bus Rides to Dog Park Stop
A black Labrador named Eclipse just wants to get to the dog park. So if her owner takes too long finishing his... Read »
2 Charged With Stealing $18K Worth of Cookies
An apparent cookie caper in Austin has led to theft charges against two men stopped with a trailer packed with... Read »
Drug-Laced Bread Causes Out-Of-Body Experiences
At least 40 people in Southern California suffered symptoms ranging from nausea to hallucinations after eating... Watch »
Man Comes Forward to Claim Boa Constrictor Found in San Diego Toilet
The great mystery of the 5-foot boa constrictor that slithered from a toilet at a downtown San Diego PR firm is... Watch »
Man in "I Have Drugs" Shirt Arrested for Drugs
A Florida man who was wearing a T-shirt that said "I have drugs" was arrested for drug possession... Read »
WATCH: Fireworks Factory Explodes in Colombia
A cameraman was knocked off his feet while capturing this incendiary footage of a fireworks factory explosion near... Watch »
Naked Man Broke Into Homes, Used Hot Tub: Police
Police near Salem, Oregon, say they arrested a naked man after he broke into two homes, drank booze and used a hot... Read »
Person Stuck in Chimney Saved in 2-Hour Rescue
A person stuck and injured in a Southern California chimney had to be rescued Saturday morning, fire officials said.... Read »
Knife-Wielding Sushi Chef Foils Restaurant Robbery
An alleged robbery in Illinois unraveled when a man authorities say was hoping to get away with some money from... Read »
Car Part Removed From Man's Arm 51 Years After Crash
Fifty-one years ago, Arthur Lampitt, of Granite City in downstate Illinois, smashed his 1963 Thunderbird into a... Watch »
WATCH: Scratch-Off Thief Stops to Chat on Phone
Police are looking for a man who was caught on video stealing scratch-off tickets from a Bronx restaurant, and... Watch »
Hasbro to Replace Phallic Play-Doh Toy
Hasbro Inc. says it will replace a Play-Doh toy that looks similar to a penis. Read »
Florida Keys Man Arrested for Pulling Gun on Naked Neighbor
A Florida Keys man is in jail for pulling a gun on his naked 56-year-old neighbor who had his music too loud... Read »
High School Athlete Dragged to Death in Driveway
A 20-year-old man is charged with vehicular homicide following the dragging death of a high school athlete during an... Read »
Florida Truck Driver Crushed by Storage Pod
Authorities say a Florida truck driver has died from injuries suffered when she was crushed by a 5-ton storage pod... Read »
Fla. Woman Tried to Hire Hitman to Kill Husband: Deputies
Polk County deputies say they've arrested a Lakeland woman for trying to hire a hitman to murder her husband who... Read »
Man Calls 911 When "Babbling" Wife Keeps Him Awake: Cops
All he wanted was a good night's sleep. Instead, a Middletown, Connecticut, man found himself in trouble with the... Read »
Orangutan Has Right To Freedom: Court
An orangutan at an Argentine zoo shares certain human rights and therefore has a right to be transferred to a... Read »


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Rep. Steve King says he thinks there will be debate about upcoming budget issues and the debt ceiling, but he says he doesn't think there is a will to have another government shutdown in this Congress.
Rep. King: I don't think there will be another gov't shutdown
posted on October 25, 2013
Stories From This Episode
This story is part of Iowa Press #4108, which originally aired on October 25, 2013. Read all stories from this episode:
- U.S. Representative Steve King (R - Kiron)
- Rep. King says it remains to be seen if Sen. Ted Cruz has staying power
- Rep. King: I don't think there will be another gov't shutdown
- Rep. King says immigration debate is bad for Republicans
- Rep. King says Rep. Latham should not face primary opponent
Related Stories
Iowa Party Chairs
(Mar. 27, 2015)Jeff Kaufmann, chair of the Republican Party of Iowa, and Dr. Andy McGuire, chair of the Iowa Democratic Party, are the guests on the this edition...
Party chairs on Grassley 2016 and the candidate "benches"
(Mar. 27, 2015)Iowa Democratic Party Chair Dr. Andy McGuire says her party won't give Sen. Chuck Grassley a free pass to re-election, but no candidate has formally...
Kaufmann: Reasonable Republicans can disagree on gas tax
(Mar. 27, 2015)Republican Party of Iowa Chair Jeff Kaufmann says there are disagreements among conservative Republicans over the passage of a gas tax increase this...
McGuire: We've got to rebuild some of our grassroots
(Mar. 27, 2015)Iowa Democratic Party Chair Dr. Andy McGuire says she doesn't think her party has done enough in rural Iowa. She says she thinks rural Iowans are...
Party chairs hint at Caucus results reporting changes
(Mar. 27, 2015)Republican Party of Iowa Chair Jeff Kaufmann and Iowa Democratic Party Chair Dr. Andy McGuire say they're excited about changes and improvements...


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Are you Fernando Formaggio?Claim your profile
Publications (421)1188.72 Total impact
[Show abstract] [Hide abstract]
ABSTRACT: In contrast to the extensively investigated β-turn conformation in peptides and proteins, single and multiple γ-turns have been poorly studied. Single and non-contiguous multiple γ-turns have been relatively often authenticated in small cyclic peptides, but these important peptide main-chain reversal motifs have been examined carefully neither in linear peptides nor in globular proteins. This Perspective article summarizes literature data on this aspect of peptide stereochemistry, expanding the discussion also to the rarely found, contiguous multiple γ-turns which generate incipient or fully-developed 2.27-(γ-) helices. Unpublished results of recent research activities on this topic ongoing in our laboratories are also briefly outlined.New Journal of Chemistry 11/2014; DOI:10.1039/C4NJ01564A · 3.16 Impact Factor
Article: The peculiar N- and C-termini of trichogin GA IV are needed for membrane interaction and human cells death induction at doses lacking antibiotic activity.[Show abstract] [Hide abstract]
ABSTRACT: Peptaibiotics, non-ribosomally synthetized peptides from various ascomycetes, are uniquely characterized by di-alkylated α-amino acids, a rigid helical conformation, and membrane permeation properties. Although generally considered antimicrobial peptides, peptaibiotics may display other toxicological properties, and their function is in many cases unknown. With the goal to define the biological activity and selectivity of the peptaibiotic trichogin GA IV from the human opportunist Trichomonas longibrachiatum we analyzed its membrane interaction, cytotoxic activity and antibacterial effect. Trichogin GA IV effectively killed several types of healthy and neoplastic human cells at doses (EC50%=4-6μM) lacking antibiotic effects on both Gram(-) and Gram(+) bacteria (MIC>64μM). The peptaibiotic distinctive C-terminal primary alcohol was found to cooperate with the N-terminal n-octanoyl group to permeate the membrane phospholipid bilayer and to mediate effective binding and active endocytosis of trichogin GA IV in eukaryotic cells, two steps essential for cell death induction. Replacement of one Gly with Lys plus the simultaneous esterification of the C-terminus, strongly increased trichogin GA IV anti-Gram(+) activity (MIC 1-4μM), but further mitigated its cytotoxicity on human cells.Biochimica et Biophysica Acta (BBA) - Biomembranes 10/2014; DOI:10.1016/j.bbamem.2014.10.005 · 3.43 Impact Factor
Article: Solution Synthesis, Conformational Analysis, and Antimicrobial Activity of Three Alamethicin F50/5 Analogs Bearing a Trifluoroacetyl Label[Show abstract] [Hide abstract]
ABSTRACT: We prepared, by solution-phase methods, and fully characterized three analogs of the membrane-active peptaibiotic alamethicin F50/5, bearing a single trifluoroacetyl (Tfa) label at the N-terminus, at position 9 (central region) or at position 19 (C-terminus), and with the three Gln at positions 7, 18, and 19 replaced by Glu(OMe) residues. To add the Tfa label at position 9 or 19, a γ-trifluoroacetylated α,γ-diaminobutyric acid (Dab) residue was incorporated as a replacement for the original Val(9) or Glu(OMe)(19) amino acid. We performed a detailed conformational analysis of the three analogs (using FT-IR absorption, CD, 2D-NMR, and X-ray diffraction), which clearly showed that Tfa labeling does not introduce any dramatic backbone modification in the predominantly α-helical structure of the parent peptaibiotic. The results of an initial solid-state (19) F-NMR study on one of the analogs favor the conclusion that the Tfa group is a very promising reporter for the analysis of peptaibioticmembrane interactions. Finally, we found that the antimicrobial activities of the three newly synthesized analogs depend on the position of the Tfa label in the peptide sequence.Chemistry & Biodiversity 08/2014; 11(8):1163-91. DOI:10.1002/cbdv.201300394 · 1.80 Impact Factor
Article: Energetics of oxo- and thio-dipeptide formation via amino acid condensation: a systematic computational analysis[Show abstract] [Hide abstract]
ABSTRACT: Oxo-dipeptides and thio-dipeptides are built via condensation between couples of amino acids and amino thioacids, the latter with the carbonyl oxygen replaced by an sp(2) sulfur. We explored via in silico methods (PBE0/6-31G(d,p) and PBE0/6-311G(d,p)) all the possible combinations and built 800 dipeptides, whose structures were fully optimized. Maps of condensation energies are presented to highlight optimal partners leading to stable dipeptides and critical situations for which lower stability or instability is predicted in terms of Gibbs reaction free energies. To validate the feasibility of our computational investigation, we synthesized and compared the stabilities of two thionated dimers, namely -Gly[Ψ(CSNH)]Gly- and -Phe[Ψ(CSNH)]Phe-, characterized by diverging physico-chemical properties. To the best of our knowledge, this is the first systematic analysis reported for dipeptides built from natural amino acids as well as for their corresponding thio-analogs.Physical Chemistry Chemical Physics 07/2014; DOI:10.1039/c4cp02680b · 4.20 Impact Factor
Article: Electrophysiology Investigation of Trichogin GA IV Activity in Planar Lipid Membranes Reveals Ion Channels of Well-Defined Size[Show abstract] [Hide abstract]
ABSTRACT: Trichogin GA IV, an antimicrobial peptaibol, exerts its function by augmenting membrane permeability, but the molecular aspects of its pore-forming mechanism are still debated. Several lines of evidence indicate a 'barrel-stave' channel structure, similar to that of alamethicin, but the length of a trichogin helix is too short to span a normal bilayer. Herein, we present electrophysiology measurements in planar bilayers, showing that trichogin does form channels of a well-defined size (R=4.2⋅109 Ω; corresponding at least to a trimeric aggregate) that span the membrane and allow ion diffusion, but do not exhibit voltage-dependent rectification, unlike those of alamethicin.Chemistry & Biodiversity 07/2014; 11(7). DOI:10.1002/cbdv.201300334 · 1.81 Impact Factor
Article: Peptides on the Surface. PELDOR Data for Spin-Labeled Alamethicin F50/5 Analogues on Organic Sorbent[Show abstract] [Hide abstract]
ABSTRACT: The PELDOR technique was used to obtain the spectra of distances between spin labels for mono and double TOAC substituted analogues of [Glu(OMe)(7,18,19)] alamethicin F50/5 (Alm') peptaibiotic on the surface of the organic sorbent Oasis HLB and in ethanol solution at 77 K. For the double-labeled Alm', the free radical probes are at positions 1 and 16 (Alm'1,16). The intra- and intermolecular contributions to the PELDOR time traces were separated, with regard to the fractality of the system studied. We established that on HLB the labeled Alm' molecules are prone to aggregation. The distance spectra for Alm'1,16 show that, in both adsorbed state and in ethanol solution, the peptaibiotic is predominantly folded in the α-helix conformation. We assign the asymmetry of the distance spectrum in both cases to the occurrence of an admixture of more elongated α/310-helical conformers. The portion of these conformers is higher for the peptide adsorbed on HLB. We speculate that both the broadening of the basic spectrum line at rmax = 2.0 nm and the increase in the contribution of elongated conformers might be associated with the spread of the peptaibiotic adsorption sites on HLB as compared with the more uniform Alm'1,16 trap structure in frozen ethanol solution. The aggregates of mono-labeled Alm'1 and Alm'16 also studied. The intermolecular distance spectrum for Alm'1 on HLB is shifted toward longer distances as compared with those of Alm'16. This result suggests that in the aggregates Alm' molecules are preferentially oriented with their C-terminal regions in the vicinity.The Journal of Physical Chemistry B 06/2014; 118(25). DOI:10.1021/jp503691n · 3.38 Impact Factor
Article: Photoinduced Electron Transfer through Peptide-Based Self-Assembled Monolayers Chemisorbed on Gold Electrodes: Directing the Flow-in and Flow-out of Electrons through Peptide Helices[Show abstract] [Hide abstract]
ABSTRACT: Photoinduced electron transfer (PET) experiments have been carried out on peptide self-assembled monolayers (SAM) chemisorbed on a gold substrate. The oligopeptide building block was exclusively formed by Cα-tetrasubstituted α-aminoisobutyric residues to attain a helical conformation despite the shortness of the peptide chain. Furthermore, it was functionalized at the C-terminus by a pyrene chromophore to enhance the UV photon capture cross-section of the compound and by a lipoic group at the N-terminus for linking to gold substrates. Electron transfer across the peptide SAM has been studied by photocurrent generation experiments in an electrochemical cell employing a gold substrate modified by chemisorption of a peptide SAM as a working electrode and by steady state and time-resolved fluorescence experiments in solution and on a gold-coated glass. The results show that the electronic flow through the peptide bridge is strongly asymmetric, i.e. PET from the C-terminus to gold is highly favored with respect to PET in the opposite direction. This effect arises from the polarity of the Au-S linkage (Auδ+-Sδ-, junction effect) and from the electrostatic field generated by the peptide helix.The Journal of Physical Chemistry A 06/2014; 118(33). DOI:10.1021/jp503791w · 2.78 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Three approaches for the chemical ligation of peptides to cotton fibers are described and compared. This investigation was encouraged by the need to create peptide-decorated natural textiles, furnished with useful properties (e.g. antimicrobial activity). IR absorption spectroscopy is proved to be an easy and fast method to check the covalent anchorage of a peptide to cotton, whereas for a quantitative determination, a UV absorption method was employed. We also analyzed the usefulness of electron paramagnetic resonance spectroscopy to characterize our peptide-cotton conjugates. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.Journal of Peptide Science 05/2014; 20(7). DOI:10.1002/psc.2659 · 1.86 Impact Factor
Article: Aggregation propensity of Aib homo-peptides of different length: an insight from molecular dynamics simulations[Show abstract] [Hide abstract]
ABSTRACT: Interactions between peptides are relevant from a biomedical point of view, in particular for the role played by their aggregates in different important pathologies, and also because peptide aggregates represent promising scaffolds for innovative materials.In the present article, the aggregation properties of the homo-peptides formed by α-aminoisobutyric acid (U) residues are discussed. The peptides investigated have chain lengths between six and 15 residues and comprise benzyl and naphthyl groups at the N- and C-termini, respectively. Spectroscopic experiments and molecular dynamics simulations show that the shortest homo-peptide, constituted by six U, does not exhibit any tendency to aggregate under the conditions examined. On the other hand, the homologous peptide with 15 U forms very stable and compact aggregates in 70/30(v/v) methanol/water solution. Atomic force microscopy images indicate that these aggregates promote formation of long fibrils once they are deposited on a mica surface. The aggregation phenomenon is mainly due to hydrophobic interactions occurring between very stable helical structures, and the aromatic groups in the peptides seem to play a minor role. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.Journal of Peptide Science 05/2014; 20(7). DOI:10.1002/psc.2648 · 1.86 Impact Factor
Article: Handedness preference and switching of peptide helices. Part I: Helices based on protein amino acids[Show abstract] [Hide abstract]
ABSTRACT: In this article, we review the relevant results obtained during almost 60 years of research on a specific aspect of stereochemistry, namely handedness preference and switches between right-handed and left-handed helical peptide structures generated by protein amino acids or appropriately designed, side-chain modified analogs. In particular, we present and discuss here experimental and theoretical data on three categories of those screw-sense issues: (i) right-handed/left-handed α-helix transitions underwent by peptides rich in Asp, specific Asp β-esters, and Asn; (ii) comparison of the preferred conformations adopted by helical host–guest peptide series, each characterized by an amino acid residue (e.g. Ile or its diastereomer aIle) endowed with two chiral centers in its chemical structure; and (iii) right-handed (type I)/left-handed (type II) poly-(Pro)n helix transitions monitored for peptides rich in Pro itself or its analogs with a pyrrolidine ring substitution, particularly at the biologically important position 4. The unique modular and chiral properties of peptides, combined with their relatively easy synthesis, the chance to shape them into the desired conformation, and the enormous chemical diversity of their coded and non-coded α-amino acid building blocks, offer a huge opportunity to structural chemists for applications to bioscience and nanoscience problems. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.Journal of Peptide Science 05/2014; 20(5). DOI:10.1002/psc.2638 · 1.86 Impact Factor
Article: A single-residue substitution inhibits fibrillization of Ala-based pentapeptides. A spectroscopic and molecular dynamics investigation[Show abstract] [Hide abstract]
ABSTRACT: The aggregation properties of two Ala-based pentapeptides were investigated by spectroscopic techniques and molecular dynamics (MD) simulations. The two peptides, both functionalized at the N-terminus with a pyrenyl group, differ in the insertion of an α-aminoisobutyric acid residue at position 4. We showed that this single modification of the homo-peptide sequence inhibits the aggregation of the pentapeptide in aqueous solutions. Atomic force microscopy imaging revealed that the two peptides form mesoscopic aggregates of very different morphologies when deposited on mica. MD experiments showed that the two peptides have a very different propensity to form β-pleated sheet structures, as confirmed by our spectroscopic measurements. The implications of these findings for our understanding of the mechanism leading to the formation of amyloid structures, primary responsible for numerous neurodegenerative diseases, are also discussed.Soft Matter 03/2014; 10(15):2508-19. DOI:10.1039/c3sm52831f · 4.15 Impact Factor
Article: A Quaternary Nitronyl Nitroxide α‐Amino Acid: Synthesis, Configurational and Conformational Assignments, and Physicochemical Properties[Show abstract] [Hide abstract]
ABSTRACT: To expand the presently extremely limited repertoire of known nitronyl nitroxide α‐amino acids, we report here the synthesis of a novel, conformationally constrained, quaternary, chiral residue, Aic(CN), and its subsequent conversion into a blue‐colored, imidazolinyl nitronyl nitroxide‐bearing α‐amino acid, Aic(NN). Deprotection and peptide coupling reactions were examined. The configurational assignment of Aic(NN) was achieved by X‐ray crystallographic analysis of an appropriate tripeptide. This latter investigation, accompanied by an IR absorption conformational analysis, strongly supports the view that the Aic(NN) residue is an efficient peptide turn former. Numerous spectroscopic and magnetic properties of its derivatives and the tripeptide are also described. Of particular relevance for future applications are its UV/Vis absorption, NMR, and EPR signatures. A blue, constrained α‐amino acid bearing a sidechain imidazolinyl nitronyl nitroxide was synthesized and its spectroscopic and magnetic properties were studied. It is foreseen that this turn‐supporting residue will prove to be useful as a rigid, paramagnetic probe in peptide chemistry.European Journal of Organic Chemistry 03/2014; 2014(8). DOI:10.1002/ejoc.201301765 · 3.15 Impact Factor
Article: Synthesis and Conformational Study of Model Peptides Containing N-Substituted 3-Aminoazetidine-3-carboxylic Acids[Show abstract] [Hide abstract]
ABSTRACT: Model peptides containing N-substituted 3-aminoazetidine-3-carboxylic acids have been synthesized to investigate the conformational features of these Cα-tetrasubstituted amino acids. The target peptides were designed and prepared by classical synthetic methods in solution, exploiting the convenient N-substituted 3-azidoazetidine-3-carboxylic acids as precursors. The conformational preferences of the newly synthesized peptides were investigated in solution by IR and NMR spectroscopy. It was observed that the 3-aminoazetidine-3-carboxylic acid moiety is likely a β-turn inducer. In addition, an interesting main-chain-to-side-chain hydrogen bond that forms a six-membered pseudo-cycle was detected. It connects the nitrogen (acceptor) of the azetidine ring to the amide NH (donor) of the immediately following residue. This unexpected hydrogen bond increases the number of conformational options offered by N-substituted 3-aminoazetidine-3-carboxylic acids when designing foldamers with new and predictable 3D structures.European Journal of Organic Chemistry 02/2014; 2014(11). DOI:10.1002/ejoc.201301741 · 3.15 Impact Factor
Article: The 2.0(5)-Helix in Hetero-Oligopeptides Entirely Composed of C-alpha,C-alpha-Disubstituted Glycines With Both Side Chains Longer Than Methyls[Show abstract] [Hide abstract]
ABSTRACT: The existence of the very uncommon, but potentially quite interesting, multiple, consecutive fully-extended conformation (2.05 -helix) has been already clearly demonstrated in homo-oligopeptides based on quaternary α-amino acids with both side chains longer than methyls, but not cyclized on the α-carbon atom. To extend the scope of this research, in this work we investigated the occurrence of this flat 3D-structure in hetero-oligopeptides, each composed of two or three different residues of that class. The synthesis of a terminally protected peptide series to the tetrapeptide level was carried out by solution methods. The resulting oligomers were chemically and conformationally characterized. The data obtained point to an overwhelming population of the fully-extended conformation in CDCl3 . However, a solvent-driven switch to a predominant 310 -helical structure was seen in CD3 CN. A delicate, local balance between these two conformations is confirmed to occur in the crystalline state. Molecular dynamics simulations in CHCl3 on a hetero-tetrapeptide converged to the fully-extended conformation even starting from the 310 -helical structure.Biopolymers 12/2013; 102(2). DOI:10.1002/bip.22450 · 2.29 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: A bioinspired approach is applied to photoelectric conversion devices. A 310 -helical hexapeptide bearing a pyrene unit is immobilized on a gold-covered TiO2 surface. The device is integrated for the first time in a dye-sensitized solar cell, exhibiting stability after several measurements. The approach could have promising applications in the field of optoelectronics.ChemPhysChem 11/2013; DOI:10.1002/cphc.201300901 · 3.36 Impact Factor
Article: Synthesis and Conformational Properties of a TOAC Doubly Spin-Labeled Analog of the Medium-Length, Membrane Active Peptaibiotic Ampullosporin A as Revealed by CD, Fluorescence, and EPR Spectroscopies[Show abstract] [Hide abstract]
ABSTRACT: We describe the challenging solid-phase synthesis of the medium-length (14 amino-acid residues) peptaibiotic ampullosporin A, originally extracted from the fungus Sepedonium ampullosporum, and an analog doubly spin labeled (at positions 3 and 13) with the stable nitroxyl free-radical 4-amino-1-oxyl-2,2,6,6-tetramethylpiperidine-4-carboxylic acid (TOAC). The results of a circular dichrosim investigation in methanol strongly support the view that both peptides are essentially right-handed helical, in particular endowed with a large population of α-helical conformers. We also observed a significant quenching effect from the TOAC(3) nitroxyl radical on the fluorescence of Trp(1) , compatible with that expected when both residues are closely located on the same helix segment. Combined continuous wave and three-pulse PELDOR EPR methodologies converge on the conclusion obtained from the other aforementioned spectroscopies, namely that the [TOAC(3,13) ] ampullosporin A analog is mostly folded in the α-helical conformation. A liposome leakage assay demonstrated that the membrane-modifying properties of this bis-labeled analog are remarkable and even slightly superior to those of the natural peptaibiotic itself. © 2013 Wiley Periodicals, Inc. Biopolymers, 2013.Biopolymers 07/2013; 102(1). DOI:10.1002/bip.22362 · 2.29 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: The peptide 2.05 -helix does exist. It has been experimentally authenticated both in the crystalline state (by X-ray diffraction) and in solution (by several spectroscopic techniques). It is the most common conformation for C(α) -tetrasubstituted α-amino acids with at least two atoms in each side chain, provided that cyclization on the C(α) -atom is absent. X-Ray diffraction has allowed a detailed description of its geometrical and 3D-structural features. The IR absorption and NMR parameters characteristics of this multiple, consecutive, fully-extended structure have been described. Conformational energy calculations are in agreement with the experimental findings. As the contribution per amino acid residue to the length of this helix is the longest possible, its exploitation as a molecular spacer is quite promising. However, it is a rather fragile 3D-structure and particularly sensitive to solvent polarity. Interestingly, in such a case, it may reversibly convert to the much shorter 310 -helix, thus generating an attractive molecular spring. © 2013 Wiley Periodicals, Inc. Biopolymers, 2013.Biopolymers 07/2013; DOI:10.1002/bip.22267 · 2.29 Impact Factor
Article: Alamethicin in bicelles: Orientation, aggregation, and bilayer modification as a function of peptide concentration.[Show abstract] [Hide abstract]
ABSTRACT: Alamethicin is a 19-amino-acid residue hydrophobic peptide of the peptaibol family that has been the object of numerous studies for its ability to produce voltage-dependent ion channels in membranes. In this work, for the first time electron paramagnetic resonance spectroscopy was applied to study the interaction of alamethicin with oriented bicelles. We highlighted the effects of increasing peptide concentrations on both the peptide and the membrane in identical conditions, by adopting a twofold spin labeling approach, placing a nitroxide moiety either on the peptide or on the phospholipids. The employment of bicelles affords additional spectral resolution, thanks to the formation of a macroscopically oriented phase that allows to gain information on alamethicin orientation and dynamics. Moreover, the high viscosity of the bicellar solution permits the investigation of the peptide aggregation properties at physiological temperature. We observed that, at 35°C, alamethicin adopts a transmembrane orientation with the peptide axis forming an average angle of 25° with respect to the bilayer normal. Moreover, alamethicin maintains its dynamics and helical tilt constant at all concentrations studied. On the other hand, by increasing the peptide concentration, the bilayer experiences an exponential decrease of the order parameter, but does not undergo micellization, even at the highest peptide to lipid ratio studied (1:20). Finally, the aggregation of the peptide at physiological temperature shows that the peptide is monomeric at peptide to lipid ratios lower than 1:50, then it aggregates with a rather broad distribution in the number of peptides (from 6 to 8) per oligomer.Biochimica et Biophysica Acta 07/2013; DOI:10.1016/j.bbamem.2013.07.007 · 4.66 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Replacement of a peptide bond with its thioamide surrogate is a classical method for the generation of a peptidomimetic with altered spectroscopic, conformational, physicochemical, and biological properties. In this context, we synthesized short series of terminally protected homo-α-oligopeptides based on the α-amino acids Gly, Ala, and Nle, as well as their corresponding fully thioamidated analogues. For the first time, the preparation of the latter compounds was achieved in single-step fashion through direct thionation of their oxygenated precursors. Using X-ray diffraction analysis and NMR spectroscopy we were also able to confirm that the thioamidated α-amino acid residues can easily adopt either folded or fully extended conformations.European Journal of Organic Chemistry 06/2013; 2013(17). DOI:10.1002/ejoc.201300050 · 3.15 Impact Factor
Article: 3D Structure, Dynamics, and Activity of Synthetic Analog of the Peptaibiotic Trichodecenin I.[Show abstract] [Hide abstract]
ABSTRACT: In this contribution, we report on the conformational preferences of synthetic analogs of the antimicrobial peptide trichodecenin I in solution. This 6-amino acid residue long peptide is characterized by a single, strongly helicogenic Aib residue in the central part of the sequence and is rich in the conformationally mobile Gly residues. It has been reported that, in CHCl3 solution and in the crystal state, this peptaibiotic adopts a non-helical, multiple β-turn conformation, whereas a 310 /α-helical structure was obtained from an X-ray diffraction study on a trichodecenin I analog (TDT4W6) containing the fluorescent Trp residue in position 6 (replacing Ile) and an equally helicogenic TOAC residue in position 4 (replacing Aib). In this work, we applied spectroscopic techniques and molecular-dynamics calculations, in particular, on the fluorescent TDT4W6 trichodecenin I analog with the aim at investigating its 3D-structural and dynamical features in solution. Our results revealed that TDT4W6 can be described by an ensemble of conformers quickly interconverting in the nanosecond time scale. The most populated cluster has a conformation similar to the NMR structure of native trichodecenin I in CHCl3 . However, also helical-like conformers are present, even if poorly populated and less stable under the analytical conditions.Chemistry & Biodiversity 05/2013; 10(5):887-903. DOI:10.1002/cbdv.201200388 · 1.81 Impact Factor
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Tel: (954)921-3726
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|School Membership(s)School Assoc.
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Posted: Thursday, October 2, 2014 12:02 AM
I want to hear your needs and desires! ;) I aim to please and I am fetish friendly. I stay in shape and have killer legs! I am busty with curves in all the right places. Lay your head down and let me do the rest! Lets hook up! Come get me and lets get wild together! ;)
more pics and contact info
more pics and contact info
• Location: , In your arms ;)
• Post ID: 2352294 providence


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|Medios Baños
|Tipo de propiedad
|Estancia mínima
|3 noches
Paso atrás en el tiempo para Buenos Aires Golden Age. Este apartamento histórica francesa fue construido en 1928. Fue restaurado en armonía con la elegancia y el glamour de aquella época. Decorado con arañas de cristal y antigüedades de la época, hemos creado un ambiente que honra a la casa original. Es como una fantasía que te transporta en el tiempo. Un tiempo en Buenos Aires abrazó todo lo francés. Se hicieron conocidos como la París de América del Sur. Los franceses fueron los mejor de la elegancia y el buen gusto. Un tiempo en que las mujeres fueron a París para su ropa y arquitectos fueron traídos desde Francia para diseñar los edificios hermosos. Estamos muy contentos de ofrecer a usted La Cámara de Chanel, el nombre de la "primera dama" de estilo, Coco Chanel.
Edificio con ascensor
Techos de tres metros y tres balcones con el suelo hasta el techo puertas francesas.
Lámparas de cristal
Deco antigüedades francesas y Arte
Cocina: comer bar, los mostradores de granito, lavavajillas
Lavadora secadora
Dos habitaciones con balcón francés
Medio baño dramático con paredes de color rojo lacado y lavabo de cristal iluminadas desde abajo.
Baño completo con área de tocador. , Secador de pelo, plancha Bidet
TV de pantalla plana con reproductor de DVD y sistema de sonido envolvente
Teléfono celular proporcionado
Ubicado en Recoleta, un barrio seguro, exclusivo conveniente.
Visita www. Alquiler buenosairesluxury. com
J only one hesitation about writing a reciew, I really want to come back and perhaps all these positive reviews will mean that it is booked.
But seriously, It was the most wonderful experience and I am a fairly seasoned and experienced traveller.
The apartment was magnificent - the art, furniture, art deco decor. All the conveniences, special glasses, dishes - above and beyond any expectations and experiences I have had in travelling through Europe. Mexico for more than 50 years!!
I would recommend the House of Chanel unequivocally.
J. Mitchell
Adjunct Professor
Faculty of Medicine
University or Victoria/University of British Columbia
We had a wonderful time in the lovely apartment in Ricoleta. We were met at the airport by a wonderful driver recommended and arranged by our host at the apartment, and found the place very conveniently located and extremely stylish yet practical and comfortable. It was clean and we were able to enjoy breakfast and lunches at the apartment. There were lots of great markets, delicatessens, restaurants and galleries nearby as well as fine architectural details to admire in the neighbourhood. The bedrooms were quiet, light and the internet was reliable! Altogether a wonderful spot, to which we'd love to return.
In spite of the high summer temperatures we had a wonderful stay.....the staff was more than helpful and was eager to help us in every way.....I would absolutely recommend this apartment to friends and family
This apartment is beautifully designed and had all the facilities we needed. It is located in a beautiful building, in a great safe neighborhood. We were very close to the Recoleta cemetery which has wonderful restaurants and markets. We could walk to everywhere we wanted to go in BA. The owner and property manager were wonderful. The apartment was regularly cleaned.
We intend to come back to BA, and use this apartment.
The apartment was pure luxury, furnished with exquisite and very unusual items of furniture. The deco bathroom in particular was pure Hollywood! The location in Recoleta district is perfect being close to Recoleta Cemetery (and fascinating artisan fair at week-ends), great shops and local amenities. The apartment manager and designated driver were more than helpful and really added to the whole experience with their local knowledge and recommendations. I would highly recommend this beautiful and one-of-a-kind apartment as a great base to explore the vibrant City that is Buenos Aires.
I've had some experience renting apts. in Brasil and Argentina the last ten years. It's very rare that I've found an apt. that reflects the love of the owner like this one. It's obvious in every detail, not to mention the washer/dryer and a dishwasher. Beautifully furnished, decorated, located and managed. Thank you Mariana, the gracious property manager. Thank you Carlos, who provided our ride from the airport and back again. Very professional and a good guy (use his service you'll be pleased)...tip the maid, she deserves it. Buenos Aires is too nice and the apt. is the cherry on top. Great vacation!
Situado en el exclusivo barrio de Recoleta. Todo lo que quieres está cerca. De a ambos lados del edificio, panaderías todas partes Deli. A pie de famoso cementerio de Recoleta. El recién inaugurado Recoleta Village cuenta con un centro comercial y el teatro Cineplex. Buenos Aires Design está lleno de tiendas para el hogar. Museo de Bellas Artes está prácticamente en su patio trasero. Paseo de la feria de artes Recoleta los fines de semana. Todo dentro de un corto paseo de la vivienda.
Otras Actividades: ver enlace comercial http: // www. NYTimes. com / presentación / 2011/02/27 / viajes / 20110227-FORRAJEO. html?emc = eta1
|por noche
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High season
nov 1 2014 - mar 31 2015
3 noche estancia mínima
Tarifa básica
3 noche estancia mínima
|Información adicional
Longer term discounts on rates:
For 2 week stays, take 5% off the weekly rates
For 3 week stays, take 10% off the weekly rates
For 4 weeks and longer, take 20% off the weekly rates
Credit cards, Paypal and checks accepted.
El pago se realizará en la divisa (moneda) especificada en el anuncio, a no ser que se acuerde otra divisa con el propietario.


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The Journal of Humanitarian Assistance
Currently viewing the category: "Richard Norton"
The Paradox of Early Warning
On July 4, 1997 · Leave a Comment · In James Miskel, Richard Norton
Continue Reading →
The horror that has in recent months re-engulfed the region along the Rwanda-Burundi-Zaire (RBZ) border ought to be an icy splash in the face of advocates of early warning systems for humanitarian emergencies. Why? Because even though the idea of an early warning system seems to have been widely accepted as conceptually sound, early warning data about the RBZ crisis has been largely ignored.
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The Nations Oldest and Largest Scanner-Only Dealer
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Return to SpectrumForce Wideband Antenna with Mag Mount and BNC
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of 3
1 of 3 people found the following review helpful:
Great little product
December 3, 2010
Reviewer: Anonymous Person
In my humble Opinion:
This product is a definitive improvement over any antenna you can have inside your vehicle.
Small size and mag mount make it easy to install and transfer between vehicles and even apartment window sills :)
It is also very low profile which is a pro in certain applications.
I would not use this for a permanent installation, it is a bit flimsy and reception is not that great.
Considering the price this is a perfect product for part time enthusiasts look to improve all round reception.
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4 of 4 people found the following review helpful:
Great all around antenna
December 2, 2010
Reviewer: Brett Davis from San Lorenzo, CA United States
Bought this antenna back in August of 2010. The first 2 months of using it was excellent. I have transferred it from different cars about 50+ times, and have been up to 75MPH with the antenna perfectly attached, and received excellent reception. I was able to pull in CHP, and some Public Safety FREQs that were 40+ miles away, which is excellent. My problem appeared a mere 2 months after using this constantly. I noticed that I wasn't picking up as much as I used to. Upon further investigation, I noticed the coaxial cable failed is what caused the problem. It seems that inside the mag mount, where it connects to the antenna has somehow because loose/cut/pulled or who knows what, and was shorting the coaxial.
I just ordered a new replacement, and this time I am going to re-construct the area where the cable exits the mag-mount, and reinforce it so that cable can not be pulled, and maybe a little extra care around that area is all it needs, and this is a perfectly performing antenna.
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0 of 1 people found the following review helpful:
Great antenna for the price
October 22, 2010
Reviewer: Anonymous Person from Deer River, MN United States
Eliminates the choppy audio when driving with a whip antenna and greatly improves the reception.
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3 of 4 people found the following review helpful:
Great Antenna
July 19, 2010
Reviewer: RICHARD MULLANE from SOUND BEACH, NY United States
I had a thru the glass that did not work because I have the tinted widows that block the signal. As soon as I put this antenna on, I started to pick up everything !!! Its low profile and almost disappears on my roof. Great buy for the price, but just a good antenna !!
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2 of 2 people found the following review helpful:
June 4, 2010
Reviewer: Anonymous Person from CT United States
This is a great antenna for its price. i just hooked it up and i pick up everything better than before. i also pick up towns that are 30+ miles away from my home. it also seemed to be strong while on the back of my police interceptor doing 100 on the highway. i couldn't be happier!
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0 of 3 people found the following review helpful:
not to good
June 4, 2010
Reviewer: Michael from Niagara Falls, NY United States
not to good of a antenna rs ant is better
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1 of 1 people found the following review helpful:
Definite Improved Reception.
June 3, 2010
Reviewer: OldSchoolDeputy from St. Paul, MN United States
I just received this antenna and hooked it up to my older analog scanner (RS Pro 46) and got immediately better reception. I hooked it up to my newer scanner (RS Pro 106) with the same results. I was amazed. It appears to be well build and sturdy. This product would be 4 stars but I need to see how it will hold up outdoors on my vehicle.
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4 of 5 people found the following review helpful:
This item is the best there is !!!
May 21, 2010
Reviewer: Richard Estacio from Milpitas, CA United States
I am very impressed with this item. Due to
the compact size, it is quite convenient for
low profile travel. Plus, the magnetic base
is much stronger than the larger models. I
also prefer the black color coating, which
blends well in all environments. Prices are
very reasonable. Will purchase more in the future. =0)
Was this review helpful to you?
14 of 15 people found the following review helpful:
This is a GREAT antenna.
January 21, 2010
Reviewer: Alistair Wattam from Hudson, NH United States
I absolutely love this. I drove to Scannermaster to check out two different antennas that the salesman recommended and chose this one because it was low profile and low cost. I was not disappointed. I can hear aircraft as good as if I was sat in the cockpit. Everything is clearer and louder. This thing is a good mobile or base antenna (if you out it outside) Better still the antenna can be removed from the car and put in the trunk when I am at the mall and there are no marks on the paintwork. THe magent is strong enoughfor highway driving. My only regret is that I didnt buy two of them. One for the car and one for the home / office.
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Determined Cat Digs Through Massive Snowfall
Call it the ultimate scratching post.
Call it the ultimate scratching post.
Flying a paper airplane ain't just for little kids anymore.
Beginner's luck?
You know how some people feel like they're carrying the weight of the world? Well, this guy just might be.
Is this a life hack or a life quack?
In case you needed a reminder here's proof that the bond between mother and child is strong.
A lot of men struggle with getting Valentine's Day right. Well, struggle no more, thanks to Jack in the Sack.
Milk may do a body good, but it can also do some amazing things to your eyes.
Being a dog is all about choices.
Beauty pageant contestants are supposed to be known for their grace and composure. Well, maybe they shouldn't be.
Getting through the day is hard enough without these totally uncomfortable things happening.
Mother Nature isn't only wreaking havoc in the US this winter.
Do we need to keep bundling up or is spring in the air?
"Then put your little hand in mine. There ain't no hill or mountain we can't climb..." OK campers, rise and shine, it's time for some 'Groundhog Day' facts to celebrate the best movie about the goofiest holiday! If you ever wondered why Phil Connors was stuck in a seemingly endless time loop, or exactly how much time he spent stuck living the same day over and over and over, we've got that, and a lot more for you, in the latest fuzzy installment of You Think You Know Movies!
A delayed flight was music to these passengers' ears.


text:
Current address for D.N.G: Q-One Biotech Limited, Todd Campus, West of Scotland Science Park, Glasgow
Enterovirus variants in the serum of children at the onset of Type 1 diabetes mellitus
Article first published online: 24 DEC 2001
DOI: 10.1046/j.1464-5491.1999.00098.x
Diabetic Medicine
Volume 16, Issue 6, pages 509–513, June 1999
Additional Information
How to Cite
Nairn, C., Galbraith, D. N., Taylor, K. W. and Clements, G. B. (1999), Enterovirus variants in the serum of children at the onset of Type 1 diabetes mellitus. Diabetic Medicine, 16: 509–513. doi: 10.1046/j.1464-5491.1999.00098.x
Publication History
- Issue published online: 24 DEC 2001
- Article first published online: 24 DEC 2001
- Received 16 October 1998; revised 29 January 1999; accepted 12 February 1999
- Abstract
- Article
- References
- Cited By
- aetiology;
- childhood;
- enterovirus;
- Type 1 diabetes mellitus
Aims This study was designed to assess further the possible links between enterovirus infection and Type 1 diabetes mellitus (DM).
Methods Sera from 110 children in the age range 0–15 years was obtained shortly after the diagnosis of Type 1 DM, in paediatric centres throughout the UK. They were tested for the presence of enteroviral sequences by the polymerase chain reaction (PCR) of the 5′ nontranslated region (5′ NTR). One hundred and eighty-two controls tested were matched for age, geographical location and time of year.
Results A significantly greater number of diabetic children (27% vs. 4.9%, P <0.005) had evidence of enteroviral RNA sequences. Proportionally, more younger children were enterovirus PCR positive, thus eight out of 20 children aged ≤2 years were enterovirus PCR positive. Sequence analysis showed that there was considerable variation in the sequences detected, although all appeared to be of the coxsackie/echovirus type.
Conclusion This study re-emphasizes that a link exists between enteroviral infection and the onset of Type 1 DM, particularly at a very early age, and suggests that these viruses are aetiologically important in diabetes in a significant proportion of children.


text: Share this:ShareRedditEmail Mr. Tom created this freeform nightlight using the dark-detector circuit from EMS Labs. Simple LED Nightlight Gareth Branwyn Gareth Branwyn is a freelancer writer and the former Editorial Director of Maker Media. He is the author or editor of over a dozen books on technology, DIY, and geek culture. He is currently a contributor for Boing Boing and WINK Books. And he has a new best-of writing collection and "lazy man's memoir," called Borg Like Me. Share this:ShareRedditEmail


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Ultimate Kids' Bathroom
This hip haven makes it fun for kids to clean up their act with under-the-sea decor and beach-inspired accessories. Integrate an easel with a little paint and let your creative kid's imagination run wild.
By: Carolyn Gray
Creative Kid's Bathroom
Parents know the bathroom can be a battleground for kids. Either you're cajoling a toddler into the tub or arguing with a preteen over the hours they spend in front of the mirror.
Try turning the battleground into a playground with the ultimate kids' bathroom. It won't make the tots wash up and the older kids preen faster, but it will make the whole process a lot more fun. Here's how.
Toilet Fun
Play it safe with fixtures: Savvy parents choose classic colors and designs that will stand the test of time for toilets, countertops and vanities. If one of the kids using the room is very young, and there's room for a double sink, consider a two-level countertop that puts one sink in reach for the tinier tot. Make sure your ultimate kids' bathroom also has safe stepstools so that youngsters can easily reach what they need.
Have fun with accessories: Whether you have a preschooler hooked on Dora the Explorer or an older child obsessed with anime heroes, today's gotta-have-it icon will be passé before you know it. Indulge your child's taste for cartoon characters and other themes with fun and funky shower curtains, rugs, linens, wastebaskets and other accessories. These items add a lot of design fun, but are easy to swap out for the next "flavor of the month."
Chalkboard Walls
Keep it tidy: Young kids accumulate scores of plastic tub toys, action figures and picture books. Teens seem to gather enough hair and skin products to open their own salons. The ultimate kids' bath includes plenty of cubbies, bins, cabinets and other storage to make it easy for kids to keep their own space tidy. Don't forget hampers for clothes and towels.
Let creativity out to play: Kids' creativity in the bathroom doesn't have to stop with the shampoo mohawk. Cover a wall with chalkboard paint and keep a bucket of sidewalk chalk handy for your budding artists; take photos of any favorite creations so kids can erase and start over. Older kids can use the chalkboard wall for more sophisticated creations, calendar notes or even Mom and Dad's reminders to clean the bathroom.
Colorful Curtain
Get wired: For some kids, keeping the bathroom fun means media, including a TV. Essential for those preschooler screenings of Once Upon a Potty, a TV with DVD player can help keep young kids in the tub long enough to actually get clean. Don't forget the sound system: Kids love their tunes just as much as adults.
Stay safe: A hazardous bathroom is no fun for anyone. Keep all medicines out of the kids' bathroom, install GFCI outlets to prevent electric shock, and make sure all kids using the room know and follow basic safety rules.
Next Up
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Girls' Bathroom Gets Colorful Update
Designer Rebecca Hawkins gives a bathroom shared by two young sisters a sophisticated new look that will carry them right through their teen years.
Make a Pet or Baby Gate Inspired by Modern Art
Add stylish safety and separation to door openings, hallways or staircases with a child and baby gate inspired by iconic artist Piet Mondrian.
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Gather information on guest bathrooms so you can create a welcoming and efficient bath space for your home.
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Kids' Ballerina Bedroom
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April 11, 2012
Illinois Public Media News
In-depth reporting from WILL, NPR, the Associated Press, and other sources
Contact WILL News at firstname.lastname@example.com
Second-grade teacher Elizabeth Well discusses nutrition with her class.
April 09, 2012
Champaign County Schools Adopt Anti-Obesity Initiative
Page 543 of 893 pages ‹ First < 541 542 543 544 545 > Last ›
WILL Newscast audio
NPR News
Venezuela Cuts Oil Subsidies To Caribbean Nations
Despite Protestation From Brazil, Trial For 840-Pound Emerald Will Continue
Pharmacists Group Votes To Discourage Members From Providing Execution Drugs
California's Death Row, The Nation's Largest, Runs Out Of Room
Airstrikes In Yemen Intensify, Hit Refugee Camp
Judy Woodruff Recalls Assassination Attempt On President Reagan
Prosecution Rests In Case Against Admitted Boston Marathon Bomber
Ex-Feds Accused Of Pocketing Bitcoins During Investigation
Ex-Israeli Leader Ehud Olmert Found Guilty Of Corruption
An Unexpected Wilderness Cam At Britain's 10 Downing Street
More NPR News
WILL Highlights
The hidden racism of young white Americans
From PBS NewsHour: Look at data that shows the percentage of whites in each age group espousing racist ideas.
WILL-AM and reporting partners win AP Awards
A series by Illinois Public Media reporting partners won an AP award for Best Investigative Report. Former IPM reporter Sean Powers was named Best Reporter.
More than 100 people became new Friends of WILL during February. We're excited to have them as supporters!


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Dauphin County
Dauphin County News
Harrisburg Cemetery Tree Walk and History Comes Alive Tours
March 27, 2015The Penn State Extension Dauphin County Master Gardeners "Harrisburg Cemetery Spring Tree Walk" and the Camp Curtin Historical Society "History Comes Alive" tours will take place at the Harrisburg Cemetery on Saturday, April 25, 2015, from 1:00 - 4:00 p.m. The rain date is Sunday, April 26, 2015, from 1:00 - 4:00 p.m. The event is hosted by Penn State Extension Dauphin County Master Gardeners, Camp Curtin Historical Society, today's the day Harrisburg, and Historic Harrisburg Association.
Better Kid Care: Keystone Kids Go - Go Healthy...It All Begins with You!
March 26, 2015This class guides child care practitioners as they examine their own health habits, set realistic goals for areas of improvement and become a positive role model for children.
Master Gardener Hotline
March 19, 2015The Master Gardener Hotline is a free service offered through Penn State Extension - Dauphin County Office to help residents with gardening questions and concerns.
Penn State Extension News
Timber 2015 expo a showcase for Pennsylvania forest products industry
March 27, 2015Pennsylvania's large forest-products industry will be showcased during the 2015 Forest Products Equipment and Technology Exposition, June 5-6 at Penn State's Ag Progress Days site at Rock Springs. Known as Timber 2015, the biennial trade exposition is hosted by the Penn State College of Agricultural Sciences and the Pennsylvania Forest Products Association. Parking and admission are free.
Turning pollution into crop nutrients to be focus of 2015 Manure Expo
March 16, 2015As agricultural groups and government agencies continue to tackle the vexing problem of nutrient pollution entering waterways, Penn State Extension is hosting an event in the heart of the Chesapeake Bay watershed aimed at helping producers to reduce negative impacts of excess manure nutrients. The 2015 North American Manure Expo will take place July 14-15 near Chambersburg, Franklin County.
Land-use webinar to focus on planning to protect water supplies
March 13, 2015Planning for and protecting public and private water supplies will be the topic of a Web-based seminar offered by Penn State Extension at noon on March 18.
Upcoming Regional Events
Intensive Study: Tools & Logistical Ideas to Make Your Farm Market Profitable
When: March 31, 2015Where: Lancaster, PA
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Cooking For Crowds: A Volunteer's Guide to Safe Food Handling
Event CanceledWhen: April 1, 2015Where: Mifflintown, PA
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When: April 1, 2015Where: Carlisle, PA
StrongWomen/Growing Stronger
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Latest World Congress of Cardiology Stories
BEIJING, June 17 /PRNewswire-Asia/ -- Racial-ethnic groups living in a similar environment and with access to universal healthcare differed strikingly in their cardiovascular risk profiles according to new data presented today at the World Congress of Cardiology (WCC) Scientific Sessions in Beijing, China. Chinese people have the most favorable cardiovascular risk profile, followed by White, South Asians and then Blacks according to the study presented.
GENEVA, March 8 /PRNewswire-Asia/ -- In 100 days the World Heart Federation, with the support of the Chinese Society of Cardiology and the Chinese Medical Association, will open the World Congress of Cardiology (WCC) Scientific Sessions 2010 in Beijing, China. Participants from more than 100 countries are expected to attend the first international cardiology congress to take place in China, and it promises to be a truly global event.
Spain could lead the world with the launch in 2009 or 2010 of the first three-in-one "polypill" to prevent heart attacks, a top cardiologist advising on the project said on Saturday.
- The governor of a province or people.


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Recent Homework Questions About Mental Health
Post a New Question | Current Questions
ARE YOU A EXPERT TO HELP STUDENTS ON THEIR HOMEWORK LIKE ME? Bob Pursley is actually more than "a expert." He has become one of the leading experts in homework help on the board. So much so that the "International Council on World Homework Online, Learning, ...
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Many children grow up with a considerble amount of violence in their lives protrayed in movies,video games,television,witnesing family violence,or being victims of child abuse themselves. Research on the effects of violence on children indicates: 1.that all children exposed to...
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Music Question
which would NOT be a compelling reason for teaching music? 1. Musical intelligence is an aspect of intelligence or 2. Parents expect schools to teach music Wouldn't it be number 2? There are cognitive and non cognitive aspects of intelligence. The compelling reason for ...
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give an example of a human behavior that is considered deviant in one society but is not considered deviant to others. head shrinking Having hallucinations is another example. Some culture consider them communications from the spirits. Our culture typcially considers ...
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can one define postive mental attitude This is an opinion question, I am assuming. What do you think? If you still need help developing your ideas, just ask. This is as good a definition as any. http://en.wikipedia.org/wiki/Positive_mental_attitude My definition is -if ...
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Where could I find suitable literary criticism on Tennessee William's 'Cat On A Hot Tin Roof' regarding disability and disadvantage? is this a significant enough theme for there to be any useful resources on the internet? Depends. William's Cat On a Hot Tin ...
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conclusion+ paragraph! + thanks in advance!
Right before World War One, Imperialistic, territorial, nationalist, and economic rivalries had been intensifying among Germany, France, Great Britain, Russia, and Austria-Hungary. Others argue sayings that if war was going to happen dont you think it was given many ...
Monday, March 12, 2007 at 11:51am
We don't just answer questions here. We help. So at least tell us your best thought out answer and why you chose it. Then we'll help. A truck gets stuck under a bridge. Several tow-trucks are unable to pull it ou. At last a little boy walks up and asks the red-faced ...
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Is this a strong thesis statement: Ms Gilman captures the struggle of the narrator as she provides evidence of the journey of the narrators changing mental state that is not just about a woman losing her sanity but of a woman who is suffering from a feeling of entrapment...
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Please check my Health/English to see if it is better or need to do more work on it. Thank YOU Please post your essay and someone will happily proofread it for you. Please check if its better and could you suggest a Title, Thank YOU Need an introductory sentence. From 1950 to ...
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Leonardo Da Vinci
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Could you help me fine 2 more punctuation mistakes in this article? Presidential first ladies have been an active force in American politics for nearly 300 years. These women's roles have been many, and varied. In 1800, Abigail Adams, dubbed "Mrs. President," was...
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thank you for helping me religion is really hard to understand especially if your not from it or even have studied it for long. Now what are some cultural influences for having hinduism vital to the region it originates from. and what does it mean to liberate from earthly ...
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roses are red
ROSES ARE RED by JAMES PATTERSON can someone give mi an opinion about this plot summery?do i have to change somethin? From the author James Patterson comes thriller: Roses are red. In this horrific but also romantic story Detective Alex Cross, who works with FBI, tries to find...
Sunday, January 7, 2007 at 5:03pm
I've begun writing a short story for English and I was wondering if someone could check through it and maybe give me a few tips on the storyline, improvements, ect... Here it is: Chapter One It all started the day Jules McGregor moved to our school. I thought nothing of ...
Sunday, January 7, 2007 at 4:31pm
Can someone help me. I've done 4 definitions of terms. But i don't know the last one can someone check what i have and then explain to me the last one. The religion i am studying is Hinduism. Terms: Karma-(My answer)The Buddhist's judgment, which determines at ...
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I NEED HELP WITH ENGLISH HOMEWORK. WHAT MEANS VISUALIZE? Thank you for using the Jiskha Homework Help Forum. The word "visualize" is "to see" or "to form a mental image of" something. The word "vision" is associated.
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Please Proofread my essay
Weather Gone Wild -During this semester, I was to keep track of a current event. I chose to research extreme weather globally, but I was most interested in discovering if there was any sort of extreme weather happening around the United States, as well as finding out what ...
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Grammatical Corrections in my Essay...?
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Monday, November 6, 2006 at 9:56am
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Friday, October 27, 2006 at 10:48pm
how was chillingworth injuring dimmesdale without inflicting any physical injury? Was it mental torture? Did Dimmesdale suffer (mental) agony? NO
Thursday, October 26, 2006 at 4:14pm
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research project thesis
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Sunday, June 19, 2005 at 11:22pm
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Book your room at Eldorado Flat Service
Please enter your travel dates.
Family-friendly Caldas Novas condominium resort near Acqua Park diRoma
This family-friendly condominium resort is located in Caldas Novas, close to SESC Institute, Lagoa Quente de Pirapitinga, and Acqua Park diRoma. Also nearby are Feira do Luar and Matriz Church.
Property Features
Recreational amenities at Eldorado Flat Service include an outdoor pool and a fitness center. Other amenities include complimentary wireless Internet access and a business center.
Room Amenities
Guestrooms have kitchens, complimentary wireless Internet access, and refrigerators; rooms also include air conditioning and separate sitting areas.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Eldorado Flat Service features an outdoor pool and a fitness center. Public areas are equipped with complimentary high-speed wireless Internet access. A business center is on site at this 3-star property. This family-friendly condominium resort also offers tour/ticket assistance, a garden, and an elevator (lift).
- Total number of rooms - 50
- Business center
- Elevator/lift
- Fitness facilities
- Tours/ticket assistance
- Free WiFi
- Garden
- Outdoor pool
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Room Amenities
- Separate sitting area
- Air conditioning
- Refrigerator
- Kitchen
- Private bathroom
- Shower only
- In-room safe
- Cookware, dishware, and utensils
- Stovetop
- Free WiFi
Nearby Things to Do
Recreational amenities at the condominium resort include an outdoor pool and a fitness center.
Hotel Policies
Check-in time starts at 2 PM
Minimum check-in age is 18
Check-out time is noon
Payment types
Pets allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Towels/sheets: BRL 7.00 per accommodation, per night
We should mention
Parents traveling with a child under 18 must present the child's birth certificate and photo ID (passport for foreign visitors) upon check-in. If only one parent or legal guardian is traveling with the child, that parent or legal guardian must also present a notarized consent of travel signed by both parents. Visitors who plan to travel with children should consult with a Brazilian consulate office prior to travel for further guidance. One child 10 years old or younger stays free when occupying the parent or guardian's room, using existing bedding. Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation.


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NOFX Celebrate 30th Anniversary with Career-spanning LP Box Set
A press release explains that the mighty offering, limited to 2,500 copies, drops February 19 via Fat Wreck Chords and Epitaph, and will contain all of the band's albums from 1988's Liberal Animation up to last year's Self Entitled. The 15-LP package also includes a double-LP set compiling all of the group's 7-inch-of-the-month singles, which were delivered between 2005 and 2006.
You can catch the tracklisting for the 12-inch pressing of the singles down below.
The set comes housed in "a beautiful hardbound box" featuring modified artwork from their landmark 1994 LP, Punk in Drublic, among other images, and will contain coloured vinyl pressings and a life-size version of the band's banner. Five hundred copies will be signed by the group and will be split up between Fat Wreck Chords and Epitaph.
You can pre-order the box set from either label here or here.
You may remember that this isn't the first big-ass box set from NOFX. Last year, they offered up the similarly monstrous 7-inch compendium 126 Inches of NOFX.
7-Inch of the Month Club:
Side A:
1. Insulted By Germans… Again
2. Fanmail
3. Arming The Proletariat With Potato Guns
4. I Am Going To Hell For This One
5. There's No Fun In Fundamentalism
6. Fungus
7. I Am A Huge Fan Of Bad Religion
Side B:
1. Jamaica's Alright If You Like Homophobes
2. No Way
3. Getting High On The Down Low
4. You're Wrong
5. Leaving Jesusland
6. Benny Got Blowed Up
Side C:
1. Teenage Punching Bag
2. One Way Ticket To Fuckneckville
3. Your Hubcaps Cost More Than My Car
4. What Now Herb?
5. California Uber Alice
6. All My Friends In New York
7. I Melvin
Side D:
1. You Will Lose Faith
2. Last Night Was Really Fun?
3. Cool & Unusual Punishment
4. Civil Defense
5. Golden Boys
6. The Man I Killed
Coming back soon! If our developer were more machine than man they'd already be here. Useless meatsack.
For now, please send any and all feedback to [email protected].
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Cleveland has often been ridiculed as the "Mistake by the Lake."
But it might not be such a big mistake anymore.
LeBron James has always said he would have gone to Ohio State had he not foregone college for the NBA.
But he probably didn't mean he would have played football there.
The return of LeBron James to Cleveland means the Chicago Bulls will be seeing even more of LeBron.
LeBron James didn't need a video camera for this year's decision to return to Cleveland. This time, he wanted the complete opposite.
The Cleveland Cavaliers might be paying LeBron James millions of dollars to return to Cleveland, but the franchise immediately increased their value.


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The iRobot Roomba 630 has been reviewed by more than 375 customers on Amazon, averaging a customer rating of 4.60 stars out of 5. It retails for around $350, and is one of the best vacuum cleaners for pet hair that you can purchase today.
iRobot Roomba 630 Features
The Roomba 630 runs on a 1.4 amp motor, powering its suction capabilities for cleaning all kinds of dirt and debris. The vacuum boasts an advanced AeroVac three-stage cleaning system – it brushes the wall to loosen dirt, then the counter-rotating brushes pull the dust the debris inside, and then the vacuum transports it all into a large-chamber bin. The 630 features an acoustic sensor to detect dirt, making the three-stage cleaning system possible. The vacuum includes a single virtual wall, so that the 630 knows how much floor to cover, and which rooms to avoid. Once finished, the vacuum's bin is easily opened, so the dirt and debris can be discarded.
iRobot Roomba 630 Pros
Amazon customers loved the convenience and reliability of the Roomba 630's automatic features, as well as its ability to get to those hard-to-cover areas, such as under a bed or dresser and in the back corners of a closet. Some reviewers remarked at how well the Roomba picked up dog hair and pet hair, without a fuss, performing nearly as well as a regular vacuum, without much of the manual effort on the user's end. A lot of customers remarked at how skeptical they first were before using the product, but then how pleasantly surprised they became at how proficient the 630 actually performed. "The Roomba 630 has saved my house from dog hair," one customer raved.
iRobot Roomba 630 Cons
No matter how well a robot vacuum works, they're still not going to perform a full-house, deep-cleaning as well as a more traditional vacuum. A few customers wrote that the 630 was not so great on thicket carpets. Another drawback of the Roomba 630 that some Amazon customers remarked upon was that it is quite noisy when in use. A final criticism is that this specific model cannot be "scheduled", so you will have to be home to turn it on at first.


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New additions
rmac78June 21, 2012
I am excited to see how these hosta do in the upcoming years. Great Expectations I know is a touchy one but I decided to give it a try. Anyone else have any nice results with any of these varieties??
Risky Business
Great Expectations
El Nino
Stitch in Time
Hallson's sent me El Nino last summer as a bonus plant. I like it a lot and it's grown modestly. Planted it next to its parent, Halcyon. They looked fabulous together until I washed the house and Halcyon gave up its blue for green. Hoping I get a second flush of growth from Halcyon to restore some of the blue.