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Cool footwear
Great footwear - we just need to get the rest of the outfit to go with it! But we can think of that later....
Cool footwear
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22-17985 - 8" Lineman Pliers
Lineman pliers have ergonomic non-slip molded grips for user comfort and control. Made of premium quality drop forged and hardened chrome vanadium steel for long lasting durability.
Mfr Name: Performance Tool
Mfr Number: W30728
See all items in Lineman
22-16928 - 7" Lineman Cutting Pliers
Lineman cutting pliers with fixed joint design used for grasping, bending and cutting. Individually sharpened blades cut both soft and hard wire.
Mfr Name: Stanley
Mfr Number: 84-112
See all items in Side Cutting
22-16930 - 8" Lineman Cutting Pliers
Mfr Number: 84-113
22-15080 - 6-in-1 Linemans Pliers
6-in-1 lineman's pliers feature a a high-leverage design for high cutting power and precision. Functions as pliers, a reamer, bolt cutter, wire cutter, nail puller, and a fish tape puller to allow you carry less tools and get more done.
Mfr Name: Milwaukee Electric Tool
Mfr Number: 48-22-3309
22-20195 - High Leverage Lineman Pliers with Fish Tape Puller and Non-Slip Handles
Heavy duty pliers have a high transmission ratio for easy cutting. High leverage design requires 40% less effort than conventional pliers. Features non-slip plastic handles for a sure grip and a fish tape puller and universal crimper for added versatility.
Mfr Name: Knipex
Mfr Number: 09 11 240
22-20185 - High Leverage Lineman Pliers with Non-Slip Plastic Handles
Heavy duty pliers have a high transmission ratio for easy cutting. High leverage design requires 40% less effort than conventional pliers. Features non-slip plastic handles for a sure grip.
Mfr Number: 09 01 240
22-19035 - Nine Pice Industrial VDE Tool Set
Professional quality tool set feature an industrial brushed finish and ergonomic insulated cushion grips rated for safe working up to 1000V.
Mfr Name: Wiha
Mfr Number: 32999
See all items in Insulated
22-16312 - Eight Piece Precision Plier Set
A variety of precision pliers ideal for electronic maintenance and repair or work in tight spaces. Comfortable rubber handle provide a sure grip.
Mfr Name: Duratool
Mfr Number: GPL-168
See all items in Plier Sets
22-16370 - Five Piece Plier Set
Five piece set comes stored in a convenient roll up pouch for easy transport to the jobsite.
Mfr Name: Distributed By MCM
Mfr Number: GPL-500
96-3545 - 9" Pivot Pro Compound Linesman Pliers
Unique pivot action design requires 40% less force to cut. Unlike standard pliers that pivot on the center-bolt only, additional leverage can be applied. This action creates more leverage and force to the cutting edge.
Mfr Name: Crescent
Mfr Number: CCA20509
32895 - 14 Piece Insulated Tool Kit
Individually tested precision-made tools certified to 1000 volts. German precision machined for an exact fit.
Mfr Number: 32895
22-16378 - Communications Installer Kit
The perfect tool kit for network or telecommunication installers or service technicians. Everything needed to test, service or install communication devices comes in a high quality carrying bag to keep everything organized.
Mfr Number: TTK-1500
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22-19050 - Nine Piece SoftGrip Pliers and Cutters Set
Nine piece tool set contains a variety of pliers and cutters for use on a wide range of applications. Each tool has soft cushion grip which provide comfort during use. A molded storage tray keeps tools organized when not in use.
Mfr Number: 32679
22-3282 - Electronics Master Kit
A complete, portable kit for working on electronics. Perfect for the professional or hobbyist.
Mfr Name: Pro'skit
Mfr Number: 1PK-1700NA-MCM
See all items in Technician Kits
22-21725 - Technicians Tool Kit
The technician's tool kit is a versatile tool assortment of the most commonly used tools for basic home or office maintenance. Everything you could possibly need for little jobs together in a durable carrying case.
Mfr Number: PK-2052TA
MCM is our low cost, high product value source. Same quality as the more expensive vendors, without the "expensive." Always fast and dependable.


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- TRRT April 1-7 | Online Edition
- Guest Commentary: the Rockford Apartment Association
- State Roundup: NIU employee improperly reimbursed $30K
- State Roundup: Governor signs budget fix bills
- Rauner, Democratic leaders shake hands and make law
- State roundup: National guardsman and cousin arrested in terror plot
- Lawmaker says license plate readers a privacy threat
- Bryant not the first to feel impact of free agency rules
- State Roundup: Parents' group calls for standardized test opt-out bill
- Hononegah Mack: 'The best woman in the county'
Brita Climate Ride underway
Online Staff Report
Hundreds of cyclists participated in the Brita Climate Ride May 13-17, pedaling from New York City to Capitol Hill in Washington, D.C., for greater action on climate change.
Speaker at Tuesday's rally portion of the event included climate expert Bill McKibben; Keith Laughlin, president of Rails-to-Trails;Alisa Gravitz, Executive Director, Green America; and two members of Congress — Sen. Ben Cardin (D, MD) and Reps. Donna Edwards (D, MD). Both denounced the annual subsidies to the oil and gas and nuclear industries.
Laughlin called for "burning calories, not carbon," while Cardin joked that "riders belong on the streets, not attached to appropriations bills," and Gravitz shared the latest on Green America's work to make Clean Energy Victory Bonds a reality.
Climate Ride is a nonprofit organization that puts on fully supported, charitable bike rides to support sustainable solutions and environmental causes. The next journey will be from Eureka, Calif., to San Francisco Oct. 2-6.
More information is at climateride.org.


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The Sweet Stop provides personalized catering services for festivals, street fairs, concerts, corporate events, fund raisers, private parties, or any other special event needs.
A mobile catering experience, the Sweet Stop has been doing various events through California and serving to funnel cake lovers for years!
We look forward to working with you in the near future!
Al and Liz Larson, Owners
The Sweet Stop, LLC
We would love to see you! Come visit us at one of our upcoming events:
March 7, Corona America Baseball, 8AM - 4PM
March 21-22, L.A. County Air Show
March 28, Riverside Air Show, 9AM - 4PM
April 4, Rialto Spring Eggstravaganza, 11AM - 2PM
April 11, Downey Street Faire, 10AM - 5PM
April 18, Riverside Tamale Festival, 11AM - 6PM
April 19, Fallbrook Avocado Festival, 9AM - 5PM
The Sweet Stop is now on Facebook and Twitter!
Click here to follow us on Facebook and click here to tweet about us on Twitter!


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HOUSTON (AP) — Barely alive in the race for the final playoff spot in the Western Conference, the Houston Rockets focused on the one outcome they could control Saturday night.
Lee leads Rockets past Golden State
Courtney Lee scored 20 points, Goran Dragic added 18 points and seven assists and the Rockets snapped a six-game losing streak with a 99-96 victory over the Golden State Warriors.
"We needed this win, so we could get that bad feeling off our backs," said Luis Scola, who had 13 points. "We really, really needed it."
Chase Budinger added 11 points for the Rockets, who came into the game in the 10th spot in the West, one game behind Utah and Phoenix.
Minutes after their game ended, the Rockets tuned in to the start of the Orlando-Utah game as they dressed and prepared for the trip to Miami, where they will play the Heat on Sunday.
"We've been thinking about games and possibilities for all these six games. It didn't work," Scola said. "We've got to go to Miami and win one basketball game and hopefully, just hopefully, at the end of the day, we'll still have chances."
Only two weeks ago, Houston had its fate in its hands after a four-game road winning streak. The Rockets came home and lost to Utah and Phoenix, then dropped a home-and-home set against Denver, another team in the bottom half of the standings.
The Rockets lost road games at Dallas and New Orleans this week, and struggled with the lowly Warriors, who have lost eight in a row.
"We needed to find a way to win one," Houston coach Kevin McHale said. "It was just one of those games, we weren't sharp and we made some 3s to get some separation out of them. But it was another one of those games where we really weren't at the top of our game."
Klay Thompson scored 24 points and Brandon Rush added 19 for the Warriors, who have lost 20 of their last 24. The team announced earlier in the day that Andrew Bogut and Stephen Curry would undergo surgery on their injured ankles.
Golden State coach Mark Jackson used only eight players and liked their effort.
"I was really proud of my guys," Jackson said. "We were short-handed, but put ourselves in position down the stretch to win the ballgame."
Continue reading this story on the...


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Gulfstream Motorhomes that are now for sale or have been recently sold at PPL are shown below. We are currently in need of more vehicles like yours. If you have one to sell, use this link to learn how to sell your Gulfstream Motorhome Quickly and for a good price. If you would like to buy an RV, please go to the complete list of the Consigned RVs for Sale.
If you are thinking about selling your Gulfstream Motorhome, click on the button to the left and request the free booklet "Nine Steps to Selling Your RV" ... Avoid Common Mistakes. These tips and "no-nos" could save you thousands and help you avoid the headaches when selling your RV.
Stock # Description RV Type $ A132 38' 2007 Gulfstream Sun Voyager w/2 Slides Class A 69,995 A211 36' 2005 Gulfstream Sun Voyager w/4 Slides Class A 48,495 A737 33' 2006 Yellowstone Country Club w/Slide Class A 28,500
Click to sell your Gulfstream Motorhome quickly and for a fair price. To Trade Your RV, Visit our RV Trades Page or Call 1-800-755-4775 for details. D114NB 42' 2007 Gulfstream Tour Master 330hp Mercedes w/2 Slides Diesel 81,995 D759 42' 2006 Gulfstream Tour Master 400hp Cummins w/3 Slides Diesel 75,995 D792 39' 1999 Gulfstream Friendship 325hp Cummins w/Slide Diesel 33,495
Valuable free information services if you are buying, selling or own a Gulfstream Motorhome M111NB 27' 2005 Bt Cruiser w/2 Slides Class C 29,498 M190NB 32' 2008 Bt Cruiser w/Slide Class C 43,999 M193NB 30' 2011 Gulfstream Conquest Class C 37,450 M202 30' 2008 Bt Cruiser Xl w/3 Slides Class C 46,925 PEND 37' 2006 Endura Diesel w/3 Slides Class C SALE PENDING SOLD 36' 2005 Gulfstream Sun Voyager w/2 Slides Class A SOLD 41,925 SOLD 42' 2005 Crescendo 350hp Cat w/4 Slides Diesel SOLD 66,995 SOLD 24' 2005 Conquest B-Touring w/Slide Class C SOLD 22,500 SOLD 28' 2004 Bt Cruiser w/Slide Class C SOLD 23,995 People are amazed when we tell them how many and how fast PPL sells RVs. In fact, PPL has sold 2,734 consigned RVs since January 1, 2014. PPL needs additional Gulfstream Motorhomes to satisfy the strong demand of its buyers. PPL is the hassle free way to buy, sell or trade your RV. Visit the links above or Call 1-800-755-4775 for details. No representations or warranties, either expressed or implied are made as to the accuracy of the information herein.
PPL is an independent RV Consignment Dealer selling all brands of RVs. However, we are in no way affiliated with Gulfstream. The trade names Gulfstream, Ultra, Sunsport, Friendship, Atrium, Ameri-Lite, Ultra 102 Ltd, Gulfstream Conquest Sport, Ultra Supreme, Yellowstone, Cavalier, Bt Cruiser, Innsbruck, Innsbruck Supreme, Sun Voyager, Yellowstone Country Club, Tour Master, Bt Cruiser Xl, King are the property of Gulfstream and are protected by US trademark laws.
Pictures, Floor Plans, Prices and Details
View pictures, floor plans, prices and details on all of the 599 RVs now for sale at PPL Motor Homes...The Largest RV Consignment Dealer in the USA. Click here to view a Complete List of Used RVs for Sale. Check out the large selection of great values on these used recreational vehicles.
An example of just one of our floor plans is shown below:
Sell Your RV Quickly and for a Fair Price
RV Owners all over the USA are discovering PPL Motor Home's No Hassle Consignments. PPL has sold over 30,500 RVs for individual owners since 1972. Click and find out how you too can sell your RV. Experience the No-Hassle way to sell your Diesel Pusher, Motorhome, 5th Wheel or Travel Trailer. Selling your RV is not a side line at PPL...it's what we've been doing since 1972. We do not sell any new RVs as this could distract from our focus on selling your consigned unit.
The right asking price is critical for you to get the top dollar for your vehicle. Our Free appraisals are based on the experience that comes with selling over 30,500 consigned RVs since 1972.
The information at the above link will help explain why PPL Motor Homes has grown to be the largest RV Consignment dealership in the USA.
Examples of Higher Priced Motorhomes Recently Sold
Description RV Type Date Sold Price $ 43' 2011 Entegra Anthem 450hp Cummins w/4 Slides Diesel 06/2014 210,000 45' 2007 Monaco Executive 525hp Cummins w/4 Slides Diesel 04/2014 209,995 42' 2011 Ellipse 450hp Cummins w/3 Slides Diesel 05/2014 209,995 43' 2012 Aspire 450hp Cummins w/4 Slides Diesel 01/2015 201,995 43' 2011 Allegro Bus By Tiffin 450hp Cummins w/4 Slides Diesel 10/2014 201,500 45' 2013 Tuscany 450hp Cummins w/3 Slides Diesel 12/2014 200,000 39' 2012 Seneca w/2 Slides - Bunk House Class C 06/2014 125,000 24' 2014 Airstream Interstate Dsl Class C 10/2014 106,000 24' 2013 Leisure Sprinter Dsl w/Slide Class C 09/2014 92,995 26' 2013 View Diesel w/2 Slides Class C 06/2014 79,990 21' 2013 Pleasure Way Excel Ts Class C 03/2015 70,000 20' 2012 Pleasure Way Class C 09/2014 69,995
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24 Surprisingly Divisive Pooping Habits
A BuzzFeed News investigation reveals that the sit vs. stand to wipe debate is tearing this nation apart.
Toilet Talk is a BuzzFeed user and their posts have not been vetted or endorsed by BuzzFeed's editorial staff. BuzzFeed Community is a place where anyone can post awesome lists and creations. Learn more or post your buzz!


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We have the Masonite that was part of the class action and only really need to replace about 5 or 6 planks. We got scammed by a bogus construction company last October (took our 1/2 deposit and tore down the chimney and disappeared), so the budget has been cut drastically. (We were supposed to have the entire house resided with Hardiplank.)
I really only need 5 or 6 pieces to replace the ones that actually show rot. The rest of the house is really fine. I guess they were sealed properly and covered by the soffits.
My problem is finding the stuff. I've checked several lumber yards here (north of Houston, TX) but they all tell me it's all gone.
2 of them had one type of Masonite, but it didn't match mine. I have the 3 beveled (looking) 10" wide x 15 or 16' planks to do the repairs for now.
Does ANYONE know of any location that still has any of this in stock? I've done searches on google, yahoo, msn, etc., but get nothing.
Thanks for any help or suggestions!
Also, anybody have any experience in small claims with con artists? We found where the guy lives who owned this bogus company, but he claims he doesn't have any money...and we have an 'open ended contract' so he feels I don't have a leg to stand on in court. I've learned my lesson.....don't trust anyone!
- Forum >
- Roofing & Siding >
- Masonite, I only need a few!
how do I know if I really need a new roof?
Needed Pergo Presto Oak, planked PH4588
One Way Glass
I need discontnued Pergo Select 5210 Brunswick Cherry
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- 11 Things Never to Keep in Your Bedroom
- 12 Places You Never Clean—But Should!


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DEFINITION of 'Form 8949'
An Internal Revenue Service form implemented in tax year 2011 for individual taxpayers to report capital gains and losses from investment activity. Taxpayers must use form 8949, Sales and Other Dispositions of Capital Assets, to report short- and long-term capital gains and losses from sales or investment exchanges. In previous years, taxpayers used schedule D to report such transactions. Starting in 2012, partnerships and corporations were also required to use form 8949.
INVESTOPEDIA EXPLAINS 'Form 8949'The transactions that taxpayers must report on form 8949 are reported by financial institutions to the IRS and to taxpayers using form 1099-B, Proceeds From Broker and Barter Exchange Transactions. Taxpayers must use a separate form 8949 to report each category of financial transaction. They also must use form 8949 to correct any inaccuracies in the data reported on form 1099-B.
The types of transactions that must be reported on form 8949 include distributed capital gains, undistributed capital gains, sale of a main home, sale of capital assets held for personal use, sale of a partnership interest, capital losses, nondeductible losses, losses from wash sales, short sales, gains or losses from options trading, and disposition of inherited assets. This form is also used to report gains from involuntary conversions (other than from casualty or theft) of capital assets not held for business or profit, nonbusiness bad debts, and undistributed long-term capital gains from form 2439. Large partnerships and corporations may choose to also use form 8949 to report their share of gain or loss from a partnership, S corporation, estate or trust. The new requirements under form 8949 can be burdensome for active traders, especially those who trade the same investments in accounts with more than one brokerage company.
After-Tax Real Rate Of ReturnThe actual financial benefit of an investment after accounting ...
After-Tax Return On SalesA profitability measure that indicates how well a company uses ...
After-Tax Payable PeriodThe average period that a company has between receiving goods ...
Tax IndexingThe adjustment of the various rates of taxation done in response ...
Airport TaxA tax levied on passengers for passing through an airport. The ...
Tax Anticipation Bill - TABUnique bills sold at a discount and maturing within 23 to 273 ...
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Judge continues annexation hearing
A Chancery Court Judge continued an annexation hearing Tuesday for at least another 30 days after several people filed an objection to the land being annexed into the city of Oxford. (April 4, 2012, Page 1A)
Groups invited to take part in Party in the Park
To help provide information about organizations aimed at offering support for parents for the prevent of child abuse and neglect, several organizations have come together to hold the annual Party in the Park on April 14 at Avent Park in recognition of National Child Abuse Awareness Month. (April 3, 2012, Page 3)
Changing signs for the times
All but a handful of Oxford business are now under compliance of the city's sign ordinance that limits the size, amount and placement of outdoor signs. (April 3, 2012, Page 1)
Oxford Passion Play this weekend
The Oxford Passion Play, in its second year at North Oxford Baptist Church, will have six show times this year to give everyone who wants to see the free show the ability to come and enjoy it. Admission is free but the church asks people to get tickets so they have an idea of how many seats are available. The show opened Thursday and continues today at 7 p.m., and 3 and 7 p.m. Saturday and Sunday. For more information, call 234-1101 or visit www.northoxfordchurch.com. (March 30, 2012, Page 3B)
Transit projects need action
City leaders are remaining skeptically optimistic about much needed road projects getting started after a meeting with Mississippi Department of Transportation officials Wednesday that included Old Taylor Road roundabouts and improvements to the Highway6-West Jackson Avenue intersection. (March 29, 2012, Page 1)
Conference Center wants facelift
An interior designer recommended $400K worth of changes and upgrades for the Oxford Conference Center Thursday to the Oxford Tourism Council. Designer Courtney Jones said the changes do not have to be made all at once and the first change she recommended is getting new chairs for the center. (March 23, 2012, Page 1A)
Community to celebrate Faulkner's life, work
FULL STORY — Several events are being planned to commemorate the 50th anniversary of the death of Nobel Prize-winning author William Faulkner. A free screening of "The Reivers," lectures and other activities will take place on July 6.
Fest's success leads to changes
The success of the Double Decker Arts Festival has lead organizers to make some changes this year. While some changes are minor, one change that has some people concerned was not allowing nonprofits and churches from selling food at the festival. (March 22, 2012, Page 1)
Mayor, chancellor speak to UM retirees
Mayor Pat Patterson and UM Chancellor Dan Jones spoke about issues that affect both entities during a meeting recently with University of Mississippi retirees. (March 22, 2012, Page 2)
Grant OK'd for new farmer's market
The Oxford Board of Aldermen voted to accept a grant from the U.S. Department of Agriculture Tuesday that would go toward the salary and other administration costs associated with starting up a new farmer's market on city property. (March 21, 2012, Page 1)


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Behavior of Marine Fishes
Capture Processes and Conservation Challenges
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moreUnderstanding fish behavior in relation to capture processes in marine fisheries is of fundamental importance to reducing bycatch and discards, and to enhancing marine fisheries conservation efforts. A thorough understanding of this allows commercial fishers to more effectively capture target species while reducing the catch of unwanted species. Behavior of Marine Fishes: Capture Processes and Conservation Challenges provides the reader with principles, patterns, and characteristics on fish behavior and fish capture processes using several types of important commercial fishing gears. The book also highlights conservation challenges facing the marine capture fisheries in efforts to maintain sustainable use of marine resources and to reduce negative impacts to the marine ecosystem. This volume, with contributions from leading applied fish behaviorists and fishing gear technologists from around the world, will be a valuable reference for researchers, fishing gear technologists, fisheries managers, students, and conservationists. less
Wiley; March 2010
392 pages; ISBN 9780470961766
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Title: Behavior of Marine Fishes
Author: Pingguo He
392 pages; ISBN 9780470961766
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Title: Behavior of Marine Fishes
Author: Pingguo He
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Epizyme Inc (NASDAQ:EPZM)
EPZ-5676 DOT1L Inhibitor Findings in Phase 1 Dose Escalation Study Conference Call
November 14, 2013 8:30 AM ET
Stephanie Ascher – Investor Relations
Robert J. Gould – Chief Executive Officer
Eric E. Hedrick – Chief Medical Officer
Jason P. Rhodes – President and Chief Financial Officer
Robert A. Copeland – Executive Vice President and Chief Scientific Officer
Jonathan M. Eckard – Citigroup Global Markets Inc.
Raymond R. Chang – Cowen & Co. LLC
Gregory R. Wade – Wedbush Securities, Inc.
Charmaine Chan – RBC Capital Markets
Howard Liang – Leerink Swann LLC
Good morning and welcome to Epizyme's conference call to discuss initial results for the ongoing Phase 1 trial of EPZ-5676. At this time, all participants are in a listen-only mode. There will be a question-and-answer session at the end. Please be advised that this call is being recorded at Epizyme's request. I would now like to turn the call over to the Epizyme team. Please proceed.
Stephanie Ascher
Good morning Stephanie Ascher with Stern Investor Relations. And welcome to Epizyme's call this morning to discuss initial finding from the Dose Escalation stage of the Phase 1 Trial of EPZ-5676, or DOT1L Inhibitor. Please note that there are supplementary slides which you can find in the investors center section of the website, where you can also listen to a live webcast or replay of today's call.
Before we begin, I would like to remind that today's discussion will include statements about the company's future expectations, plans and prospects that constitute forward-looking statements for purposes of the Safe Harbor provision under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors including those discussed in the risk factor section of our 10-Q filed with the SEC on August 23, 2013.
In addition, any forward-looking statements represents our views only as of today and should not be relied upon as representing our views as of any subsequent date. While we may elect to update these forward-looking statements at some point in the future, we specifically disclaim any obligation to do so even if our views change.
Now, I'll turn the call over to Epizyme's CEO, Robert Gould.
Robert J. Gould
Thanks Stephanie. We are very pleased to provide an update this morning on the EPZ-5676 clinical program and to discuss our future plans. Before we begin, let me thank everyone and draw all of your well wishes over the past several weeks. My cardiac surgery in October was successful and I am actively reengaging here at Epizyme, while I continue my recovery.
We are highly encouraged by the results of your sharing with you today and look forward to initiating the planned MLL-rearranged only expansion stage in December. 5676 is a first-in-class, small molecule inhibitor of DOT1L histone methyltransferase. It was discovered internally by Epizyme scientists using our product platform. Epizyme along with our partner Celgene is developing 5676 for the treatment of the acute leukemias with alterations within the MLL gene.
As a result of this specific identifiable genetic alternations, DOT1L is miss regulated and causes inappropriate methylation, resulting in the increased expression of genes that cause leukemia. We have published extensive pre-clinical data on the anti-leukemic effects of DOT1L inhibition in cancers with genetic alterations within the MLL gene referred to as MLL rearranged or MLL-r and MLL-PTD. Highlights of our pre-clinical data are provided for your reference at the end of this presentation.
We are completing the dose escalation stage of on going Phase 1 study of 5676 with 16 patients enrolled in the first 4 cohorts and are very encouraged by the initial findings which I will summarize.
Eric Hedrick, CMO will then describe these results in greater detail. As a first-in-class therapeutic candidate in a novel target class, evaluating safety and tolerability were central goals for the dose escalation stage of this study. To-date, there have been no dose-limiting toxicities observed and a maximum tolerated dose has not been encountered. This favorable safety and tolerability profile is a meaningful result for the DOT1L program and the entire HMTome target class.
It is also important as it allows us to continue to both escalate the dose and modify the administration schedule in the planned MLL-rearranged expansion stage. Determining the pharmacokinetic and pharmacodynamic relationship between dose exposure and methyl mark inhibition was also an important goal for this stage. In the dose escalation study to date exposure was proportional to dose as expected.
We also saw clear dose-in-time dependent methyl mark inhibition. For the primary objectives of the dose escalation stage were to evaluate safety, PK and PD we have enrolled eight patients with acute leukemia with MLL-rearrangements in cohorts 2 through 4. We observed treatment effects in four of these MLL-rearranged patients and do not see treatment effects in any non MLL-rearranged patients.
These treatment effects included blast count reductions, differentiation effects and the resolution of the leukemia related symptoms. The safety PK/PD and treatment effects observed are consistent with the genetically defined therapeutic mechanism of action in our preclinical data. And we are highly encouraged as we move ahead to the next stage of this clinical program.
I will now turn the call over to Eric, who will provide a more in-depth review of the dose escalation study results.
Eric E. Hedrick
Thanks, Robert. I will provide more detail on the initial findings in the dose escalation stage of the study. We completed four dose cohorts with doses of 12 mg/m2/day, 24 mg/m2/day, 36 mg/m2/day and 54 mg/m2/day respectively. 16 patients were dosed within these cohorts and a fifth dose cohort at 80 mg/m2/day is currently enrolling patients. All cohorts to date have evaluated a 21 day on, seven day off treatment schedule.
The majority of the patients had a diagnosis of acute myeloid leukemia. Other diagnosis included acute lymphoblastic leukemia and chronic myelomonocytic leukemia. As Robert mentioned the re-arrangement of MLL was present in nine patients, eight with acute leukemia and one patient with chronic myelomonocytic leukemia and transformation. This is a heavily pre-treated patient population and includes six patients who are in relapse after allogeneic stem transplantation.
Overall 5676 have been extremely well tolerated and there have been very few events of adverse events of concern. Specifically there have been no dose limiting toxicities, no toxicities requiring either treatment interruption or dose reduction and no evidence to date of the dose toxicity relationship. There has been only one discontinuation of 5676 due to an adverse event. And in this case a patient with intracranial bleeding in the setting of severe thrombocytopenia related to progressive leukemia was considered unrelated 5676.
There has been only one great three event believed to be possibly related to the 5676, neutropenia in a patient that remains on study treatment as the assigned dose in the fourth dose cohort. Note that leukocytosis has occurred in two cases, but this is considered treatment related and not an adverse event. As we will be discussing greater detail in a minute, we have also seen treatment effect in four of the eight MLL-rearranged acute leukemia patients, while no such observations have been made in patients without MLL-rearrangement.
This selective treatment effect is consistent with the genetically defined therapeutic hypothesis. The pharmacokinetic profile of 5676 for the fourth dose cohort, this study demonstrates steady state exposure levels of 5676 have been dose proportional, ranging from approximately 150 nanograms per mil in cohort 1 to 550 nanograms per mil in cohort 4. Variability has been modest, 2 to 2.5 fold with the exception of a single high exposure outlier in the third dose cohort.
The pharmacodynamic effects of the 5676 on DOT1L target inhibition, as we're measuring by methyl mark inhibition of the DOT1L target H3K79 in peripheral blood mononuclear cells, has been highly informative. First, at doses greater than or equal to 36 milligrams per meter squared, methyl mark reduction has been consistently observed.
Secondly, and perhaps more importantly, the kinetics of methyl mark inhibition demonstrate declining levels of methyl mark over time throughout the 21-day treatment course with the recovery of methyl mark approaching baseline levels after the 7-day off drug period. This suggests that a continuous, uninterrupted schedule of 5676 maybe required to maximize target inhibition. Fortunately, the highly favorable safety profile seen to date supports this schedule of administration. This will allow us to evaluating an uninterrupted schedule of 5676 in the MLL rearrangement only expansion stage of the study and to potentially continue dose escalation, if indicated.
With the current 21-day treatment schedule we do observe treatment effects of 5676 in patients with MLL rearrangement. As we've noted previously, a patient with MLL rearranged acute lymphoblastic leukemia in the second dose cohort exhibited evidence of 5676 treatment effect manifested as a significant reduction in circulating blast and resolution of leukemia-related fever. In the most recent dose cohorts of the study, we're seeing three additional patients with MLL rearranged acute myeloid leukemia with treatment effects suggestive of a differentiation mechanism of activity. Some patients have also had resolution of certain leukemia-related symptoms such as fevers and cachexia. In one case, resolution of leukemia cutis, which is a cutaneous manifestation of leukemia, was noted.
Finding supportive of a differentiation effect include treatment related leukocytosis and evidence of cellar differentiation and maturation in the bone marrow, in one case with a reduction of blast percentage in the marrow. Further supportive of maturation of leukemic cells is the fact that we, through collaboration with Dr. Scott Armstrong at Memorial Sloan-Kettering Cancer Center have demonstrated the MLL translocation in mature, circulating neutrophils using a FISH analysis.
We note that these findings are preliminary and have been transient in nature with the possible exception of a patient in cohort 4, who remains on study treatment. However, given that the terminal effect of 5676 in MLL rearrangement leukemia cell lines in vitro appears to be related to differentiating effects on blast, we find these observations in patients to be very encouraging and consistent with the mechanistic hypothesis.
The fully characterized clinical effect of 5676 in MLL rearranged leukemia patients will require a longer follow-up and treatment of additional MLL rearrangement leukemia patients with the uninterrupted treatment schedule 5676 in the expansion stage of the study.
Based on these encouraging findings to date, we are moving ahead with our planned expansion with proof of concept clinical programs of 5676. As we've discussed, the current Phase 1 study in DOT1L transition to an MLL rearrangement only expansion stage this December, which will afford the opportunity to evaluate an uninterrupted administration schedule of 5676 in larger cohorts of MLL rearranged acute leukemia patients. We expect this stage to initiated the current dose of 80 mg/m2/day and again administer the drug on a continuous uninterrupted schedule. The continuous enrollment design will also allow for dose escalation wanted and the selections of Phase 2 dose will depend on the safety, PD and activity profiles of this treatment schedule.
Given the data from the dose escalation stage of the study and the treatment effects observed we expect expansion stage of the study to provide an initial assessment of clinical efficacy for 5676.
We also believe that the data from the current dose escalation study in adults supports the initiation of this study of 5676 in pediatric patients in early 2014. This study will be restricted to patients with the MLL-rearranged acute leukemia and will be similar in design to the adult study with the dose escalation phase and in expansion stage that we would expect to provide an initial assessment clinical efficacy.
Lastly, we plan to incorporate patients with the MLL-PTD abnormality into clinical trials in early 2014. These patients will be eligible during the MLL rearrangement only stage of the current study and we expect to initiate a dedicated MLL-PTD expansion cohort in 2014.
We are really pleased with the progress of the 5676 program and our entire portfolio, including EPZ-6438 or EZH2 inhibitor, which is currently in a Phase 1 dose escalation study. The 6438 study continues to enroll patients no dose-limiting toxicities have been observed to date. Across both of our clinical programs we expect to have four or more proof-of-concept studies ongoing in 2014.
I will now turn the call back to Robert.
Robert J. Gould
Thanks Eric. The 5676 Phase 1 study is proceeding as planned. As 5676 is a first-in-class inhibitor in a novel target class demonstrating a highly favorable safety and tolerability profile is a significant milestone and a necessary precondition for moving ahead. The treatment effects that we have observed in acute leukemia patients with MLL-r during the dose escalation stage are consist with a therapeutic mechanism of actions for this program and are clearly encouraging.
2013 has been an enormously important year for Epizyme as we translate the science of epigenetics into innovative, personalized therapeutics for patients with genetically defined cancers. 2014 will be another important year for Epizyme, the entire field and most importantly for patients as we advance our clinical programs in multiple proof-of-concept study.
Thanks everyone for your time and attention this morning. We'll now take questions.
Question-and-Answer Session
Thank you. (Operator Instructions) Our first question comes from Jonathan Eckard with Citi. Your line is open. Please proceed.
Jonathan M. Eckard – Citigroup Global Markets Inc.
Good morning. Welcome back, Robert, and thanks for taking the questions. I was just wondering, if – a couple here. Could you just let us know if there was any common mechanism of progression or form of progression in the patients in the trial? And then my second question is regarding the rebound, I guess based on earlier data it seem like the 5676 actually had a pretty high residence time on the histone, and I was wondering if that rebound or the magnitude of that rebound was surprising and how that could be impacting the clinical results today. Thank you.
Eric E. Hedrick
Hi, Jon. Thanks for the question. This is Eric. Yes, in regard to the type of progression of disease, we cannot seen one particular pattern. They have all been fairly typical for the way that acute leukemic patients would progress either progression based on rising blast counts in the blood and or marrow, but we've not seen any one particular unusual pattern in the progressive disease cases. And maybe I'll let Bob comment on the kinetics of the methyl mark.
Robert J. Gould
Thanks Eric and thanks for the question. Actually the rebound data that we are seeing is quite consistent with the preclinical data and the long residence time that we've associated with 5676. That rebound is measured seven days after the cessation of dosing. We don't have any intermediate time points between stopping the dose and that seven day point. And if you look at the data even after seven days without drug the methyl mark has not returned to baseline.
And so that is completely consistent with our preclinical data, and that rebound based on the preclinical data will be a function of the dose as well as the duration of the exposure to the drug that we see and so moving to an uninterrupted schedule and higher doses we think will be most beneficial to patients.
Eric E. Hedrick
Yes, this is Eric I guess. If anything I would add is one of the I think important things for learning from the study so far is that 5676 has differentiated in qualities and if think of differentiation agents in leukemia, the kinetics of the response require that you treat for prolonged periods, and I think we are happy to see particularly safety wise that we are going to be able to do that, so I think that's probably one of the more important things we learned from the study so far.
Jonathan M. Eckard – Citigroup Global Markets Inc.
That's great. I'm sure there is other questions, so I will get back into queue.
Thank you. And our next question is from Simos Simeonidis with Cowen & Co. Your line is open. Please proceed.
Raymond R. Chang – Cowen & Co. LLC
Good morning, it's Ray Chang actually in for Simos this morning. Thanks for taking the question. I just wanted to ask why – if you could comment on why you think the other four MLL-r patients didn't respond. Was their response perhaps in terms of methylation that did not translate to a clinical response? And if this is the case, just wanted to get your thoughts on what the hypothesis may be.
Eric E. Hedrick
Yes, hi, Ray. Thanks for your questions. You know maybe I'll start out just kind of reminding people that this is a dose escalation study and the point here is really to understand safety and tolerability primarily and the fact that we're seeing treatment affects is encouraging, but I think we'd be too preliminary to draw any conclusions about rate of response. I guess the thing I would also say is that we're now at dose levels where we're hitting the target consistently. We understand those schedule and that's likely to be optimal and I think that really encourage value and as we go into this expansion phase we're only treating MML-r disease at or get inhibited dose adding up the scheduled really to get a better sense of clinical efficacy.
Raymond R. Chang – Cowen & Co. LLC
Okay, great. Thanks. I'll get back in the queue.
Eric E. Hedrick
Thank you. And our next question is from Greg Wade with Wedbush. Your line is open.
Gregory R. Wade – Wedbush Securities, Inc.
Hi. Good morning and thanks for taking my questions. Robert, welcome back, and Eric, congratulations on a little success that occurred yesterday. It is something you worked on as well. I wonder if you might expand on some of the work that's being done to identify characteristics of the responder population and perhaps the nonresponder population. I know you have sort of addressed this previously. But is there any commonality in the history of what patients have received perhaps in prior treatment that might predict response or absence of response? And what basic science are you doing on samples to better characterize this? Thanks.
Eric E. Hedrick
Thanks, Greg. And maybe I will start kind of toward the end of that question. In that we're looking at a variety of factors that can potentially correlate response including the particular fusion partner. We are going to be able to assay for changes in gene expression profile ultimately. So I think we are looking at a variety of things that in time, once we have a better appreciation of the efficacy we can start to tease out responder versus nonresponder.
As to what we'd able to say at this point is really limited. I mean this population in general is a typical AML Phase 1 population. It's really highly pretreated and includes many patients who failed allo transplant, which obviously gives you a sense of how heavily these patients have been treated. And so I guess the other that's important to keep in mind is really starting to understand this drug as a differentiating therapy. And remember that differentiation therapy is sort of cause-response over a different time course than cytotoxic therapies. So I mean that's why we really think that once we get into the next stage of study we're delivering the drug in an optimal way and we're able to follow patients for longer that we are just going to get a better sense of the kind of questions you have.
Gregory R. Wade – Wedbush Securities, Inc.
And then just to quickly expand on that. Was there any similarities in the way the patients responded in terms of changes in methyl mark, the time course of that response, and then their subsequent clinical response? And then lastly, if this is a differentiation effect, is there a rational combination that you think would make sense based upon the changes that you are having on the tumor? Thanks.
Eric E. Hedrick
Yes, and so again, with limited numbers of patients it's difficult to comment definitively on the pattern. What we can say is that all the patients who have had treatment effects have had methyl mark inhibition, so there is some correlation there. And again, we'll just need to treat patients with an optimal schedule for longer to further understand whether there is a typical profile involved. All the patients who have had treatment effects have started to manifest those effects within the first treatment cycle. That is one other thing that we have seen. And then – I'm sorry – I forgot the second part of your…
Gregory R. Wade – Wedbush Securities, Inc.
Once you have differentiated the tumor, is there a rational combination that makes sense?
Eric E. Hedrick
Yes, so it's interesting. So at ASH this year, we'll be some preclinical data that looks 5676 in combination with most or all of the standard-of-care leukemia treatment agents and we tend to see synergistic activity. And again, what's the mechanistic basis mechanistic basis of this, I'm not sure we entirely understand. But it would make sense that a differentiation effect, which is really addressing one of the fundamental properties of leukemia cells, right, differentiation blockade, would lend itself towards combination with other agents. And I think the other thing that's encouraging even at this early point is that toxicity-wise, we don't see any reason why we wouldn't ultimately be able to combine this drug with other agents in the clinic.
Jason P. Rhodes
Greg, this is Jason Rhodes. Thanks for the question. So we see pre-clinically very clearly is that with sufficient dose and exposure over time that we really have profound tumor regression as a single agent. And the data that we've seen so far in the clinical study doesn't give us any reason to think that that won't translate.
Our observation really is that 21 days is not a sufficient period of exposure and of course, we are still dose escalating. So we'll continue to increase dose as well. And so assuming that this is a differentiating effect that we're seeing, that will take some extended time course we believe to see that kind of durable efficacy. We think of that longer-time course just to be very clear about it. It is not indefinite.
We know that we're talking about with other differentiating periods of let's say up to 60 days. And so again we don't know anything today that will cause us to think that we will need significantly different time course. So given that the expansion stage will help us to assess this question of whether we can get to efficacy with a change in the administration schedule presuming that that's the case, we do continue to plan to develop this drug as a single agent. That said the synergy that we see in combination we are presenting at the ASH; there are number of abstracts that published recently.
The ability to see increased efficacy in combination is attractive, at a subsequent stage of clinical development and we imagine that we'll probably pursue that as well over time.
Robert A. Copeland
And this is Bob Copeland. I'd also just add to that to remind folks that in the preclinical setting in both cell culture and in venografts, the differentiation effects that we saw across a range of different MLL rearrangements were always terminal.
Okay, thank you. (Operator Instructions) Our next question is from Jonathan Eckard with Citi. Your line is open. Please proceed.
Jonathan M. Eckard – Citigroup Global Markets Inc.
Hello again. Just was wondering a couple more questions. Do you think you need to add the 28-day continuous infusion into the Phase 1 before starting the expansion cohorts for safety just for safety reasons?
And the other one is could you explain what were the criteria for progression in this Phase 1 trial? And based on the mechanism, as well as the results you've seen, would there be logic in potentially incorporating a modified response criteria that may allow for minor progressions in the early part of treatment in order to get to a point in the treatment course where the drug could kick in?
Robert J. Gould
Thanks. May I will tackle the last part first. So how to judge progression in the study really is a discretionary and the investigator makes a call as to whether the disease is stabilized or is improving in some way or has progressed and might think you made a good point which is, this drug doesn't look like it's directly cytotoxic. It looks like it works through other mechanisms with those kind of agents. Yes, you need to integrate in kind of the clinical assessment into the standardized response criteria. And if you wouldn't mind repeating the first part of the question, that would be great.
Jonathan M. Eckard – Citigroup Global Markets Inc.
Well, the first part was, do you feel that you have to I mean, I know the drug has been safe to date, but is it needed to do a 28-day continuous infusion in this Phase 1 portion before starting the expansion cohorts?
Robert J. Gould
Now, we think that we can directly go into the continuous, uninterrupted treatment schedule. We've really seen no toxicities that are recoverable, where you need the seven day off period to recover and so we feel entirely comfortable migrating straight into that schedule.
Jonathan M. Eckard – Citigroup Global Markets Inc.
Okay. Thank you.
Thank you. And our last question is from Michael Yee from RBC Capital Markets. Your line is open.
Charmaine Chan – RBC Capital Markets
Hi, this is Charmaine on behalf of Michael. Thank you for taking our questions. First one has to do with the number of cycles that patients in cohort 2 and 3 have had completed to date. And since you are following them and they get treatment effects quite early, are you seeing any changes in these treatment effects?
And secondly, with the uninterrupted dosing going forward in the next expansion trial, can you help us understand how that might or might not impact the frequency and grades of neutropenia that you are seeing because you do have one patient with Grade 3 in cohort 4. Thank you.
Eric E. Hedrick
Sure. And so that's Charmaine. The first question is really about the length of therapy in the cohorts thus far. So actually the longest treatment course on study so far has been four cycles and they think on slides that we accompanying the presentation today, you'll see that in the third dose cohort of particularly the patients who had treatment effects who ultimately had progression disease have between two and three cycles of therapy. But I think it's safe to say – and there were patients in the fourth dose cohort who are ongoing study treatment. And so I think that the bottom line is again because of what's becoming clear about the mechanism of action of the drug versus the continuous treatment schedule over multiple cycles is what's going to be required here.
Yes and that sort of relates to expectations for the next stage of the study and once we start administrating the drug in what we believe to be an optimal way will be able to really understand the clinical efficacy in a much more clear way.
Charmaine Chan – RBC Capital Markets
And the neutropenia and the uninterrupted administration?
Eric E. Hedrick
Yes. So neutropenia has not been an event that has been a recurrent event in the study. And so what to make of one patient that's an isolate neutropenia we're just not sure and that's been one of the interesting encouraging findings today when you look across the adverse events. There is really nothing that stands out as a recurrent event that would make us think of an association. So I mean at this point of the study we're really fortunately just dealing with kind of isolated occurrences and I don't know if that predicts anything for the next stages of study.
Jason P. Rhodes
All right. And this is Jason. I'll just eco something that Eric said. So this study was obviously dose escalation study designed to assess safety PK and PD and it was meant as a prelude to the expansion stage that we planned to initiate next month. So in terms of the study design, we're very pleased with the results. We have a very clear understanding of the safety and tolerability profile which is highly favorable and we also understand PK to be dose proportional and regarding PD that it's dose and time-dependent.
So we think we are in a very good position to actually ask the question about whether we can achieve durable efficacy in the expansion stage, recognizing that it was a dose escalation study, not a Phase 2 or an efficacy study. We were nonetheless very fortunate to see a number of leukemia patients with MLL-r and to then see treatment effects both in terms of blast count reductions and also leukemia related symptoms among a set of them that are consistent with the genetically defined therapeutic hypothesis.
So in regard to those two things, the result of the study really have exceeded our expectations and we are very excited and very interested as I think everyone in this call is, to begin the expansion cohort stage with this modified administration schedule and to be able to assess efficacy and also continued safety obviously coming to that study.
Charmaine Chan – RBC Capital Markets LLC
All right. I agree, and the data is very interesting. The last point I would just make is given this promising early results, is there a correlation to whether you think 80 mgs is in the biologically effective range from preclinical studies, anything that would lead you to think that you're sort of hitting in the right dosage range already? Thank you.
Eric E. Hedrick
Yes. So based on what we've seen so far, we know that 80 milligrams will be within the target inhibitory range. What we need to understand and this is highly suggested by the data so far that if we don't interrupt the treatment, we will drive towards maximal target inhibition and that's really what we need to understand first in the next stages of the study and then we have a design that will allow escalation if needed, but I think we're at a really get starting point in that, we know that starting dose is going to be a target inhibitory dose and then we will be very interested in learning early how will the uninterrupted schedule relates to the extend of methyl mark inhibition and hopefully the treatment effects that we hope to continue to see.
Charmaine Chan – RBC Capital Markets LLC
Great, that's very helpful. Thank you guys.
Eric E. Hedrick
Sure, thank you.
Thank you. And our last question is from Howard Liang with Leerink Swann. Your line is open.
Howard Liang – Leerink Swann LLC
Hi, thanks very much. I guess it's a very small number of patients, but do you feel that there is a dose response beyond what you described in the treatment effect column. Just is there anything that you see there is a dose response?
Eric E. Hedrick
Yeah, thanks Howard. As you felt the number is really too small to make that sort of conclusion. We do know that once we get above 36 milligrams per meter square, we are inhibiting target not square we are seeing these treatment effects and so the optimal effects will be on activity. I think we want to really understand until we start giving this drug and then optimize way without the drug holiday.
Jason P. Rhodes
Right. Howard, this is Jason. What we see and this is on Slide 11 in the presentation is that, the methyl mark at doses in both the third and fourth dose cohort are continuing to decline and so just as we are approaching what we think based no pre-clinical data is sort of a necessary inhibitory level to drive efficacy, we are pulling patients off drug and fundamentally that schedule is obscuring this treatment effects that we are seeing and that could over time translate into efficacy. And so we are obviously very interested in continuing to understand both the time dependency, but also the dose dependency and think we are well setup to explore that and understand it in the expansion stage.
Howard Liang – Leerink Swann LLC
I may have missed it, but what was the reason why this dosing regimen which drug holiday was chosen?
Jason P. Rhodes
Yes. I think this gets back to the fact that this is first-in-class drug against a completely novel group of targets. It is first HMT inhibitor ever to be tested in patients and there the right thing to do was design this conservatively from the start and allow for off drug period in the event that we saw toxicities that were required that what we know now is that we are not seeing those toxicities.
Howard Liang – Leerink Swann LLC
With the optimized regimen, can you talk about for this disease what you would like to see, whether it would be full-blown CRs, PRs, or bone marrow suppression?
Jason P. Rhodes
Yes and so we're evaluating this drug as it would any potential leukemia agent and we will be using sort of the standardized response criteria that guide for how active and efficacious drug is. So we will be looking for this drug to actually induce responses post end-of-life criteria.
Howard Liang – Leerink Swann LLC
Okay, thank you very much.
Jason P. Rhodes
Yeah, thank you Howard, we appreciate it.
Thank you. And I am not showing any further questions at this time. Mr. Gould, please proceed with any further remarks.
Robert J. Gould
I just wanted to conclude by thanking everybody for their time and attention to this and hope you got a sense of our excitement and enthusiasm for 5676 as we move into the expansion cohort in our only patients with the 80 milligram per kilo dose, as well as the continuous infusion.
I think the pristine safety profile that we've seen today is the dose proportional pharmacokinetics and pharmacodynamics that we demonstrated with really the objectives that we targeted in the first Phase 1 study and we are highly encouraged by that. So thank you very much for your time and attention.
Ladies and gentlemen, thank you for participating in today's conference. This does conclude the program and you may all disconnect. Everyone have a great day.
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Enderlin hosting 3-on-3 tourney
Enderlin is hosting a 3-on-3 basketball camp on Saturday, Sept. 22.
The tournament is open for boys and girls in grades 3-12 and open divisions. Cost is $80 per team. Deadline to register is Sept. 3. Tournament will be held at Enderlin School.
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Golden Falcon Karate Centre
This centre focuses on building students' self-confidence, courage and self-discipline. Instructor Pradeep (Black Belt 7th Dan) is chief examiner of the GCC.
Time Out Dubai,
- Previous reviews
This centre focuses on building students' self-confidence, courage and self-discipline. Instructor Pradeep (Black Belt 7th Dan) is chief examiner of the GCC.
Is this your establishment? Want to update any details? Please send your updates here.
can u plz tel me .. class timigs & fees details...
and where exactly this location is ..?
whn exactly the best time to join?
I am 29 years old and i want learn karate. so, is it possible? if posible how can i join? plz, i am waiting your reply.
Thank you so much.
i would loke to lurn WTF with u may i know a bot fee and transportation pls?
Hy i am new for this sport i would like to take classes for taekwondo so for the moment i can not say anything but after that sure i will share my experience with you.
Do you have Tae Kwon Do in your dojo? How much will be for the training fee per month? Schedule of training also?
Thank you very much...
Which karate style are you having in your dojo? How much will be the fee per month of training?
Thank you very much....
Best afternoon tea in Dubai Cake, sandwiches, tea and lashings of cream at Dubai afternoon teas
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Dubai's best outdoor bars 25 top places to spend a night under the stars
Best pizzas in Dubai From dial up to dine in we've eaten the best pizzas in Dubai
Dubai's best dim sum Recommended spots to sample this quintessential Chinese dining pastime
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86 Friday brunches to try Time for brunch? We run through the options - in price order
56 lunch-break buys Start your style revolution from the comfort of your desktop with these ...


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Fairfield Inn & Suites Las Vegas South
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Continental Breakfast
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Travel Blogs from Las Vegas
On a Mission
We braved the back streets of Las Vegas in search of Miss B's lollies and Graceyn's lalaloopsy doll. No doll but found the lollies. We did manage to buy another suitcase to take all our purchases home. Still working on Bloss to go on the Grand Canyon tour ...
Getting Out of Dodge
... up the Christmas shopping so that is one more thing to cross off the to-do list. There was a bit of a break in the weather and the sun popped out so we took a walk along the trail from the mouth of the Nicomekel River where it empties into Mud Bay. The trail leads past Nico Wynd golf course, a local marina, and the Stewart Farm House. The trail also winds through an old stand of cedar and fir trees that you wouldn't expect to find so close to the road. The following day ...
Reverse Culture Shock
... late Saturday night since he was the last person we saw before leaving North America a year ago when he drove us to the airport in Los Angeles after spending a couple days together in Las Vegas. With Daniel, we spent time watching football in the sportsbook and just catching up. Harlan and Janice arrived late Monday night and we saw them on Tuesday for the first time. They were both battling some kind of bug or flu, but seemed to turn a corner when they got ...
Vegas or bust
... My boy was well chuffed.
We made our way downstairs to put (or rather, give) our money into the first pokie. Yeah, that wasn't a successful trip, Damian walked away up and i walked away with not much more than a 35 cent voucher after putting in $5. Big spenders!
We grabbed the car and cruised the strip for the first time. The neon lights bright, the music loud and the people moving up and down the strip yelling and laughing. Our ...
Hoover dam and the high roller
We all had a pretty good nights sleep in our lovely Hotel room despite it being vey hot. Woke up to another scorcher and this time we left fairly early to head out to Hoover Dam, which was approximately thirty miles out from Vegas itself, basically on the border of Nevada and Arizona. Visiting the dam was a suggestion by Ginny, and we weren't quite sure what we were going to encounter when we got out there but it was a fantastic place to visit. The Dam itself has been the scene of ...


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- ELI Innovations & Implementations—START: Student Technology Assessment, Resources, and Training
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Recycling Bins Coming to Las Cruces
POSTED: Monday, March 14, 2011 - 5:58am
UPDATED: Monday, March 14, 2011 - 11:08am
LAS CRUCES - 36,000 homes in Las Cruces with city trash pickup, will be getting curbside recycling bins this week.
The city is reminding everyone to make sure all recyclables are clean and empty.
Las Cruces curbside pickup begins the week of April 4th; exact schedules are distributed with the bins.
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Updated 05/09/2014
For breakfast or lunch (or dinner until 9 pm, November–April), this roadside cafeteria a quarter mile from the Miccosukee Indian Village provides the best menu variety along Tamiami Trail in Everglades territory. Atmosphere comes from the view overlooking the River of Grass, servers wearing traditional Miccosukee patchwork vests, and a mural depicting American Indian women cooking while men powwow. Catfish and frogs' legs are breaded and deep-fried. Besides pumpkin and
Indian fry bread, you'll also find burgers, salads, and south-of-the-border dishes. The Miccosukee Platter (around $25) offers a sampling of local favorites, including gator bites.
U.S. 41, 18 mi west of Miccosukee Resort & Gaming; 25 mi west of Florida's Turnpike, Miami, Florida, 33144, United States
Restaurant Details:
Updated 05/09/2014


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Know your Douglas County commissioners' interests
Douglas County Commissioners have set committee assignments for 2012. Find out who represents your area of interest.
Commissioner meetings are held on the second and fourth Tuesday of each month at 9 a.m. in the Commissioners Room at the Douglas County Courthouse, 305 8th Avenue West, Alexandria.
For information on how to contact the commissioners, visit www.co.douglas.mn.us or call (320) 762-2980.
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Altiris Inventory Reporting - How do we modify existing report's drilldown to open in new window?
Created: 30 Jul 2013 | 2 comments
There are some useful reports in Altiris but the drilldown behavior, opens it in the main report window and you end up having to click on another report and get back in to the parent report you are viewing. Is there a way to modify this behavior? where drilling down will just open up another window instead of the current window? here is an example out of the box report "Count of Computers by Form Factor"
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Jump to content
|Last action by
|Java Program in Software created by our members
|Bloodborne in Sony Console
|Looking for feedback on my Java programs in Programming (C#, C++, JAVA, VB, .NET etc.)
|100049.... any point...? in Microsoft Beta (Windows 10)
|Alan Wake Franchise has sold > 4.5M units in Gamers' Hangout
Posted 14 March 2013 - 21:53
Posted 15 March 2013 - 06:29
Not sure, if sarcasm or plain stupid.
Posted 15 March 2013 - 14:24
Posted 15 March 2013 - 15:54
I ate that pringle with light made with Olean brand olestra oil, but I hate them so much already. I research about this, and they are very dangerous that they will make you so fat. I already throw them away. Same as Sugar-free are very dangerous. The real sugar came from sugar cane plant they are safest. Olean brand olestra oil is part of chemcials. I don't trust USA health anymore, because they wants more money.
Posted 15 March 2013 - 16:08
Uh.. what?
Can anyone decipher that for me? I can't make head nor tails of most of it, and what I could was just plain incorrect...
Posted 15 March 2013 - 16:13
^ Pringles light, potato chips, or crisps.
Olestra is supposed to lower fat absorbtion.
Apparently he does not trust evil American processed foods.


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I'm very happy with this services and I like it mooooore its safety and fast. I dont forget this site and i will order from it all the time...Read More ->
My poor mind just cannot fathom and how reliable and good MJM Magic's services are. I have recently bought some things from MJM and realised that I...Read More ->


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Vitamins & Supplements Search
The content below was selected by the WebMD Editorial staff and is solely under WebMD's editorial control.
Considering taking a vitamin or supplement to treat Dysmenorrhea? Below is a list of common natural remedies used to treat or reduce the symptoms of Dysmenorrhea. Follow the links to read common uses, side effects, dosage details and read user reviews for the drugs listed below.
Your search for Dysmenorrhea returned 13 matches.
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Today on WebMD


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WEST SACRAMENTO, CA (MPG) - The Code for America Fellowship officially launched in West Sacramento in February. The Fellowship pairs local governments with teams of mid-career, civic-minded technologists for one year. The governments and Fellows explore answers to local challenges by engaging with the community, building applications, and testing the results. Over the past four years, the Fellowship program has produced more than 55 web apps with 30 municipal governments and 103 Fellows.
The applications are tangible results of a process that builds much more than a piece of technology. By working in an iterative, user-centered, data-driven way, the program strengthens key capabilities within local government and communities that ultimately shift how cities think about and use technology to deliver public services.
SACRAMENTO REGION, CA (MPG) - Ten-thousand people came from all over Sacramento and beyond to have a fun and colorful time on the evening of Saturday, February 28th at the Color Fun Fest fun run. Hosted at Cal Expo, the family-friendly event featured daytime and nighttime 5K fun runs, food trucks, copious amounts of neon-colored powders at several color stations, and high voltage black lights once the sun went down.
"Color Fun Fest is about coming out and having an amazing time with your family. We're a family throwing family events. We want people to get off the couch, we want kids to put down the video games, we want kids to come out here and have an amazing, epic time," said Fun Director Jamie Leibert.
Gage Fernandez (9) of Sacramento did just that. Fernandez convinced his family to come out and run in celebration of his recent birthday. And what was his favorite part of the race? Being color-bombed, of course. "I loved it!" he exclaimed. "I liked how at the paint stations people would just grab [color] and throw it at you."
SACRAMENTO REGION, CA (MPG) - Sacramento County-based Eppie's Great Race, known as "The World's Oldest Triathlon," has earned the California Park & Recreation Society's highest honor. On February 13th, the beloved and popular annual event was inducted into the California Park and Recreation Society's Hall of Honor.
The California Park and Recreation's (CPRS) Hall of Honor was established in 2004 in order to honor professionals, programs, facilities, collaborative partnerships and foundations that have positively influenced the quality of life within the region. CPRS, District 2 represents 19 counties across California, and publicly advocates for the California Park and Recreation profession.
SACRAMENTO REGION, CA (MPG) - Repeating its success from three previous years, Sacramento International Airport has been ranked fourth in North America for customer service by Airports Council International (ACI), the international trade association for commercial airports.
The awards were determined by the cumulative results of Airport Service Quality (ASQ) surveys collected in 2014. ASQ Awards recognize the best airports based on passenger surveys and are the only global survey measuring passengers' satisfaction while still at the gate. All airports use the same questionnaire and follow the same scientifically designed methodology.
WEST SACRAMENTO, CA (MPG) - On February 16th, 1935, Thomas P. Raley opened his first store on Main Street in Placerville and advertised it as "the nation's first drive-in market." So began what has become known as Raley's Family of Fine Stores, a now-integral part of many California and Northern Nevada communities.
Today, with 128 stores and approximately 13,000 employees, customer service remains a priority, along with providing busy, health-conscious families with delicious, easy meal ideas at an everyday value.
SACRAMENTO REGION, CA (MPG) - Color Fun Fest 5K is a family-owned and -operated event that is currently traveling across America inviting people of all ages to celebrate life at a unique festival and 5K. And now the Color Fun Fest 5K is coming to the Sacramento region. This exciting event will be held at Cal Expo on Saturday, February 28th.
Color Fun Fest brings the Holi Festival (the Indian festival of colors) and the electronic dance movement together for the first time with a day and night glowing color 5K run. Two 5Ks will be hosted in one day; participants can choose between the day or night events or can choose to do both!
SACRAMENTO REGION, CA (MPG) - Just as soon as the California Senior Legislature (CSL) adjourned its 34th Annual Legislative Session, it announced its top ten State Legislative Proposals for 2015.
One of the top ten proposals included the medication labeling proposal, which would require all prescribers to include the purpose of the medication with their prescription. The prescription drug label may include that purpose unless the patient or the prescriber requests that this information be omitted.
The California Death with Dignity Act would authorize adult California residents who are mentally competent and terminally ill to make a request to receive medication for the purpose of ending their lives in a humane and dignified manner. This would not be classified as a suicide or homicide and would provide immunity from civil or criminal liability.
SACRAMENTO REGION, CA (MPG) - The Internal Revenue Service (IRS) and the Free File Alliance announced the launch of Free File, which makes brand-name tax software products and electronic filing available to most taxpayers in California for free.
Free File software can help taxpayers with tax preparation, including the health care law that will affect almost everyone. California taxpayers can use Free File software immediately.
Free File is available only at www.IRS.gov/FreeFile, thanks to a partnership between the IRS and the Free File Alliance, a consortium of 14 leading tax software companies.
SACRAMENTO REGION, CA (MPG) - Caitlin Wong and Andreea Luca of the United Way Young Leaders Society fold and sort clothing at Next Move Sacramento's community donation center on Martin Luther King Day to honor Dr. King's legacy of volunteerism. Ten members of the group cleaned and reorganized the donation center, which provides free items for community members who were once homeless who need clothes and household goods.
The United Way Young Leaders Society is a diverse group of young professionals ages 21-40 that is focused on philanthropy and service in the greater Sacramento region. Members are committed to investing in health and education opportunities for students by volunteering their time, mobilizing social networks, and raising money for a specific community impact project.
For more than 90 years, United Way California Capital Region has brought together nonprofits, businesses, donors, volunteers, community leaders, and more to meet the community's greatest needs, give immediate aid, and find lasting solutions for future generations. United Way mobilizes members of the community to be first responders in repairing the education level, financial stability, and health of everyone in Amador, El Dorado, Placer, Sacramento, and Yolo counties through donation and volunteer opportunities. To donate or volunteer, visit www.yourlocalunitedway.org.
Source: Kristin Thébaud Communications
WEST SACRAMENTO, CA (MPG) - A local developer, Mandarich Developments of Rocklin, recently submitted a proposal to develop a small-lot, single-family residential development in the multi-family residential (R-3) zone at 3151 Southport Parkway. The General Plan designation for this property is high-density residential. This designation provides for single-family and multi-family residential units. The project site is approximately 18.3 acres and is currently undeveloped. Southport Business Land Park Fund X, LLC of Newport Beach is the current owner.
City staff was not aware of any controversial issues regarding the property, although the proposed density for the project was at the bare minimum. For approval of the project, the Planning Commission looked at the size of the lots and the building setbacks. Since the proposed project is an R-3 zone, it has a 40% open space requirement. The zoning ordinance requires a minimum of two parking spaces for each single-family home. Each home would have a two-car garage that would be accessed from private alleys.
SACRAMENTO REGION (MPG) - The California Chamber of Commerce has released a list of new laws that will affect California businesses in 2015. Some of these, such as mandatory paid sick leave, make significant changes to the state's legal landscape. Others will have more limited impact. Here are some highlights.
Mandatory paid sick leave: AB 1522, the Healthy Workplaces, Healthy Families Act of 2014, requires employers to provide paid sick leave to any employee who worked in California for 30 days. Employers can limit paid sick leave to 24 hours or three days in each year of employment and can put a maximum cap on total accrual of 48 hours or six days. The effective date for the paid sick leave benefit is July 1st, 2015.
SACRAMENTO REGION, CA (MPG) - Optimism is strong for ongoing growth of the Sacramento regional economy in the New Year.
In direct contacts with top Sacramento regional employers, Pacific Staffing has discovered that 84% of company contacts expressed optimism for 2015 about ongoing economic and job growth in our region. Just 8% of those contacted in 2014 between November 12th and December 16th indicated a pessimistic outlook. Another 8% didn't or couldn't answer when asked, "Are you optimistic or pessimistic about the economy in 2015?" In what is traditionally the slowest period for hiring, the Sacramento Employment Trends Survey has learned the majority of top regional employers will continue at a robust pace in hiring for the first quarter of 2015.
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With the Purchase of a LakeVu HD Ultra or a Canada LakeVu HD Ultra (Models: 15149669, 15712979) and a qualifying Garmin echoMap™ or GPSMAP® series
Valid February 16, 2015 — May 31, 2015
View Details
The GPSMAP 5x7 Series combination chartplotter/sounders have 60 percent more processing power than the previous generation for faster zooming and panning. With the integration of the high-sensitivity 10Hz GPS/GLONASS receiver, the new GPSMAP 5x7 Series combos are able to update position and heading ten times per second, providing significantly smoother on-screen navigation. This industry-leading GPS receiver dramatically improves the ability to mark and navigate to waypoints and also allows for vessel movement to be crisp and fluid on screen. Also includes full wireless connectivity. The 547 Series come preloaded with both Garmin U.S. offshore and U.S. lakes cartography. Although the water may be choppy, navigation won't be.
See what's below with HD-ID Sonar: HD-ID target tracking technology gives you better separation and definition of images for the clearest possible picture of what lies below. You see fish. You catch fish. Easy.
Experience the advantage of CHIRP: The sonar technology that you've been waiting for is now built into this combo. When used with a compatible CHIRP transducer (sold separately on page 20), these combos can display crystal-clear sonar images to help find the next hidden fishing spot, ship wreckage or diving location. With Spread-Spectrum technology, you'll see unprecedented target separation and resolution at extraordinary depths, and you can dial into specific frequencies to target certain fish species. Bottom contours are more visible and signal noise is suppressed at greater depths to provide a more timely interpretation of what's below for safer navigation and better fishing.
Capture sonar recording: Sonar recording coordinates the timing of the sonar return with your boat's position and saves digital information on the map.
The West Advisor articles have answered boaters' questions and provided solutions to boating problems for more than 20 years. West Marine has compiled one of the Web's most comprehensive collections of technical boating information articles.


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Convoy From Rio Linda To Dixon Remembers Tow Truck Driver Killed In Hit-And-Run
Tow truck drivers laid to rest one of their own who was killed in a high-and-run on Highway 50.
Tow Truck Driver's Widow Pleads For Driver Who Killed Him To Come Forward
Jamie Bower's voice cracked as she tried talking about her husband Michael in the past tense. The loss has been so traumatic, she says she still can't bring herself to tell their 3-year-old daughter.
Tow Truck Driver Killed On Highway 50 Identified; Search Continues For Big Rig That Hit Him
Michael C. Bower, 29, of Dixon pulled in his tow truck at around 7:50 p.m. on Monday night on westbound Highway 50 near Jefferson Boulevard. The truck was having mechanical issues, and he placed emergency triangles at the back of his truck as a precaution for other drivers.
Anonymous Donors Help Dixon Woman Replace Scooter Stolen Before Christmas
Meek was born with cerebral palsy and has a hard time getting around. Her scooter gave her mobility, until thieves stole it from her garage.
Thief Steals Scooter Belonging To Dixon Woman With Cerebral Palsy
She relies on her scooter to do everything, and it was taken from her garage just a couple days before Christmas.
Woman Behind Billion-Dollar Movie Studio Promise For Dixon Indicted On Federal Fraud Charges
The 32-count indictment charges Carpenter, 51, with mail fraud, wire fraud and three counts of making a false statement to a government agent.
Visitors Stuck Inside World's Largest Corn Maze Calling 911 For Help
What's supposed to be fall fun has some people turning to law enforcement for help. Several visitors to the world's largest corn maze at Cool Patch Pumpkins in Dixon are calling 911 when they find they can't get out.
District: Student With Gun Arrested Near Dixon High School
District officials say that Dixon High School was put on lockdown Wednesday morning due to a student with a gun at the nearby park.
California Drought Causing Pumpkins To Ripen Early, Shortens World's Largest Corn Maze
Cooley doesn't expect the drought to dwindle his Halloween business this season, but the future of Cool Patch Pumpkins all depends on the weather.
Sacramento Residents Perplexed By Early-Morning Smell
What some described as marijuana burning was actually from an overnight barn fire in Dixon near Midway and Sikes roads.
Hay Fire In Dixon Causing Unsually Smelly Smoke
If the Sacramento area smells a little funky Thursday morning, officials say it's probably from fire burning in Dixon.
Dixon Residents Protesting Sewer-Rate Hike With Red Ribbons
The planned increase would pay for a new sewer treatment plant in down. Residents say they got 15 percent of registered voters to sign a petition, but in the end, the council voted 3-2 to keep it off the ballot.