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Name _____________________ Investigating the Height of a Stack of Rice Cakes Objective: to use collected data to develop a model and make predictions. Procedure: 1. You have been given 9 cakes. Create a stack of rice cakes using as few or as many as you wish. Use a metric ruler to measure (to the nearest 0.1 cm), the height of the cake stack and record your data below. Repeat this process for a total of five different measurements. You will be using your measurements that you choose to make a prediction of a stack of 10 cakes so choose wisely. Place cookies on a paper towel, not directly on your desk! Number of Rice Height of Stack Cakes (cm) 2. Use the data collected to predict what the height of 10 rice cakes would be. Briefly explain how you arrived at this number. 3. Once you have written your hypothesis, ask your teacher for another rice cake. Measure the height of a stack of 10 cakes and record the measurement. ______ cm 4. Was your predicted height for 10 cakes correct? Explain. 5. We will now enter the collected data into a mathematical model using Excel. Go to the following website: http://academic.pgcc.edu/~ssinex/excelets/. Scroll down to the third table (it is a mustard yellow color). Click on "Investigating the Height of a Stack of Cookies ("Just add data" Excel)" and open the Excel file if it does not open automatically. 6. Click on the "Cookie Stack Height" tab and input your data into the table. Note that you may leave the height of stack column blank for data points you did not collect. 7. The spreadsheet will calculate a line of best fit by performing a linear regression. The blue line is the line of best fit that shows the trend of the experimental data. Describe what the graph looks like: 8. Using this model, we are able to make predictions. Find the predicted height of a stack of 15 cookies by entering "15" in the yellow box labeled "enter number of cookies" and then press the Enter key. Repeat this process for 150 cookies. Record the predictions based on your model below: Number of Cookies = 15, Predicted Height _______________ Number of Cookies= 150, Predicted Height _______________ 9. The computer has generated a model based on your experimental data. Which predicted height do you think is the most accurate on your model, 15 cookies or 150 cookies? Explain. 10. Get with another group and combine your cookies to carefully form a stack of 15 cakes. Measure the height of the cookies and record the value here. ______ cm 11. Compare the predicted cake height to the actual cake height. How accurate is the model? 12. Do you think your predictions would be more accurate with more experimental data? Explain. 13. List at least 2 possible sources of error that might account for any differences between the predicted and experimental values. 14. If you were given enough supplies, how could you verify the calculated prediction for the height of 150 cookies? How practical would it be to do this? 15. How would the graph change if regular sized cakes were used instead of mini rice cakes? 16. Scientists often use mathematical models of data in their research. What are some of the benefits of modeling data?
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Whoever Runs Waffle House's Twitter Account Is a F*cking Awesome Bacon…
I'm just saying, the Waffle House Twitter account is a very satisfying follow. Observe: »
I'm just saying, the Waffle House Twitter account is a very satisfying follow. Observe: » 1/17/13 9:54am 1/17/13 9:54am
Have you been following the Whitney Houston news for the past week? Did you catch her funeral today? Does that make you hungry for waffles? #wafflehouse! Ugh. » 2/20/12 7:40pm 2/20/12 7:40pm
This seems lifted from The Onion but it's not. According to the WSJ, FEMA Administrator Craig Fugate uses a 'Waffle House Index' to help him determine how destructive a hurricane has been to an area. If a Waffle House is closed, you're probably screwed. » 9/01/11 10:53am 9/01/11 10:53am
Daniel Moore, an 18-year-old from Gainesville, was arrested after his cellphone "somehow" dialed 911, leading cops directly to his prescription drug deal. » 5/20/11 8:00am 5/20/11 8:00am

subset: commoncrawl


text: Change it back to White Stag! Do you all love Made in Oregon for making it easy to buy your parents kitschy tourist crap whenever they come visit you from whatever midwest shitpile you moved here from? Where the fuck was the outrage when they tore down Jello's phone booth so Taco Bell could have a drive thru?


text: OverviewBack to top of page LG Sciences - No Infuse - 240 ml. Code#:56871 Manufacturer:LG Sciences Size/Form:240 ml. Packaged Ship Weight:1.25 Servings:48 Dosage Size:10 Legal Gear NO Infuse™ may Produce BIGGER, Fuller Muscles. No Infuse may Increase Vascularity and Blood Flow and increase Site Specific Pumps. No Infuse may Increase Strength, Power and Endurance and increase targeted Delivery Of Nutrients To Muscles Cells Rather Than Fat Cells. No Infuse may Provide Speedier Recovery From Exercise. No Infusion is Nitric Oxide The Right Way.


text: What's Hot in Aging Research at USC: Past, Present, and Future. The USC Leonard Davis School of Gerontology will be hosting their sixth annual interdisciplinary symposium, "What's Hot in Aging Research at USC?" on April 20, 2015. USC is at the forefront of aging research incorporating the advances in technology to create a better future for our aging population. USC's academic experts give you an in-depth look into the past, present, and future of research and development at the USC campus. Details at http://gero.usc.edu/uscagingresearch/


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Short Cuts
Successus, and Marcellus, We are African martyrs, 10 April.
Saint Katharine Drexel, Religious (Feast Day-March 3) Born in 1858, into a prominent Philadelphia family, Katharine became imbued with love for God and neighbor. She took an avid interest ... continue reading | shop
St. Joseph was born at Cupertino, in the diocese of Nardo in the Kingdom of Naples, in 1603. After spending his childhood and adolescence in simplicity and innocence, he finally joined the ... continue reading
St. Gregory, born at Rome about the year 540, was the son of Gordianus, a wealthy senator, who later renounced the world and became one of the seven deacons of Rome. After he had acquired ... continue reading
Benedictine bishop of Grenoble, France, patron of St. Bruno. He was born in the Dauphine region and became a canon of the cathedral in Valence. In 1080, while attending a synod in Avignon, Hugh was ... continue readingMore Saint of the Day
Little is known of her life, and the information was received by private revelation from her. Martyred at about age 14 in the early days of the Church. In 1802 the remains of a young woman were found in the catacomb of Saint Priscilla on the Via Salaria. It was ... continue readingMore Female Saints
St. Michael the Archangel - Feast day - September 29th The name Michael signifies "Who is like to God?" and was the warcry of the good angels in the battle fought in heaven against satan and his followers. Holy Scripture describes St. Michael as "one of the chief ... continue reading
The name Gabriel means "man of God," or "God has shown himself mighty." It appears first in the prophesies of Daniel in the Old Testament. The angel announced to Daniel the prophecy of the seventy weeks. His name also occurs in the apocryphal book of Henoch. He was the ... continue reading
� Ansgar was born of a noble family near Amiens. He became a monk at Old Corbie monastery in Picardy and later at New Corbie in Westphalia. He accompanied King Harold to Denmark when the exiled ... continue reading
St. Thomas Aquinas, priest and doctor of the Church, patron of all universities and of students. His feast day is January 28th. He was born toward the end of the year 1226. He was the son of ... continue reading
By Alex Basile
Every carpenter must practice patience. We can learn important lessons from the wood shop in Nazareth from the humble Saint Joseph. I have always been a "do it yourself" type of guy thanks to my father. My dad is always a steady presence during my home-improvement ... continue readingMore Christian Saints & Heroes


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|Reviews for The Endless Sky: Perfect
| Remare chapter 1 . 4/9/2013
Oh derpy
Shes gonna need
Alot of muffins...
| tjamesbeard chapter 1 . 11/26/2012
Please, please stop being so damn good at writing, I need my sleep...
Not sure whether I'll read the one about ember...screw it, on my way there now.
Still awesome.
| Questionable Object chapter 1 . 1/16/2012
Oh god why are you so amazing?
Tug on my heart strings much more and you'll tear it out of my chest.
| jman377355 chapter 1 . 12/15/2011
I was kind of expecting rape to be honest so this comes as bit of a relief.
| Taking a Chance chapter 1 . 11/28/2011
That was... tough to read. It makes me sad because I can read this and think to myself, "There really are people who can be this cruel to another"... things like this always make me wonder how "God" could stomach some of the things that take place in his world. I really liked how you captured the emotion and pain of Ditzy-Doo's pain of being judged as a retard and how her own body has become a prison. I can honestly say that I without a doubt, hate this story. No offence to you of course, it was wonderfully written and you did a great job. I'm just saddened by how this probably happens all the time in reality.
Your new fan,
| P3MF Alpha 3-Richter chapter 1 . 11/4/2011
Gah. Late reply. D:
I think you handled Derpy's emotional distress and somewhat of a mental breakdown very well, the way she denied to the last moment her lover was anything but a two-timer.
The way she felt anxiety and distrust growing after he left her really brought out an emotional factor of abandonment, even if it broke poor Derpy's heart in two...
Derpy having her emotions reach a peak and burst out in anger at her father truly does show the weakness Derpy is feeling after being betrayed in love and seeing a pony almost die by her friend's hand.
You also handled her realization of motherhood sink in realistically, especially the way she thought her father would be ashamed of her.
The ending keeps hold of the feel that Derpy is trying to live a normal life, but on the inside she knows she is still facing inner turmoil about what's she's done.
Kudos again. Great story.
| Heart of Blades chapter 1 . 10/27/2011
What an emotional roller coaster! Fantastic job. You know, it's amazing how Derpy seems so happy go lucky and mostly okay (aside from a few outbursts and things) in TES, but this really gives us a clearer view on just what an emotional wreck she is. It's very sad how her self image and feelings about her self are true for a lot of people.
I can't say I'm surprised with what happened with that unicorn :(. And Derpy's final conversation with her dad was very heartbreaking. Over all, this is a wonderfully tragic story. One can only hope it works out in the end, but it's clear the road to get there won't be so nice
Huge appologies for taking so long to read this, but I'm glad I finally did. Also, seeing that the title is based on the P!nk song, well, it's just perfect, lol
| Merchant of Menace chapter 1 . 10/12/2011
Woo! Another great story!
| DreadedCandiru2 chapter 1 . 9/18/2011
I find her lack of faith in her father and herself disturbing; granted, it makes me look forward to Crossroads even more so that she can reconcile with Ember and drink the tall, cool glass of "Get your head out of your plot" she needs.
| Quill Inkwell chapter 1 . 9/18/2011
I thought that things might go like this, but... but...
(Damn it, Quill, pull it together. You told yourself you weren't going to cry.)
This story had an amazing resonance to it. Everything felt incredibly real, and it killed me to see what happened to Derpy. The instant we saw her go off with that rotten so-and-so in TES, I knew Derpy was going to be in for a rough patch.
I just can't get over how horrible I feel for her. To want so badly for somepony to love her, and to have that used against her. It left me hurt and more than a little angry. Excellent job, inciting such strong emotion!
I can't wait for Pegasus and Pie chap. 3- I need something cute and lighthearted after all this.
| Jasper Sealights chapter 1 . 9/18/2011
This is definitely my new favorite thing you've written!
Your portrayal of Derpy is just...beyond adorable. She's perfect in every way. How could anyone not want her? I'd give anything to have a cute little silly bouncy derpy-eyed Pegasus who eats muffins living in my house! Hah. But despite how cute and silly she can be, you REALLY pulled off her more mature, rebellious side as well, and I LOVE that. It makes so much sense for Derpy to be doing things like this, even if it is sad as hell.
To be honest, my favorite parts were the beginning, and the scenes when Derpy first gets back to the cabin, and the scene where she finds out Dusky is gone, just because of how heartbreaking it is. I can't BELIEVE that asshole. I mean, I kinda saw it coming, but...still. It was horrible. Especially him leaving her in the forest: that probably broke my heart more than anything.
Anyways, despite Dusky being an ass, you are AMAZING at writing sex. I wish I could write sex that well! LOL. It was a great length, and I liked that while there's detail, it's not a detail OVERLOAD that makes things disgusting. So yeah, I highly commend you on that! WRITE MOAR SEX.
Hah... but yeah. Derpy's thoughts after the sex, and her thoughts after coming back to the cabin, might be my favorite thing in this whole shot. I love how innocent her mind is, despite not being a virgin anymore, and also, I LOVE her love for Gilda. Ya know what, I take it back: her love for Gilda is my favorite thing about this shot. It was so, so sweet, and it just fits so perfectly. Also, the scene where Derpy tackles Gilda twice - amazing. Made me smile like a dog.
I feel so bad for Derpy right now. All the shit she's going through, her pregnancy, and her issues with her dad. I'm really glad she wrote the letter to her dad before going to Ponyville, though. It totally makes sense for her to lash out at his over-protectiveness sometimes, and feel like he'd hate her for doing something totally unlike what she'd usually do.
My heart just broke when she was having all those happy thoughts about Dusky... yeah I can't stop typing... but this review is getting long as hell, so I probably should. UGHHH.
This was a wonderful, wonderful one-shot, and I cannot WAIT to see all those lose ends tied up! I'm so excited for Crossroads, SO HURRY UP AND START IT!


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Pronunciation: Ministre de l'Education
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Pan American Silver Corp. (PAAS) Ex-Dividend Date Scheduled for February 28, 2013
Pan American Silver Corp. ( PAAS ) will begin trading ex-dividend on February 28, 2013. A cash dividend payment of $0.125 per share is scheduled to be paid on March 18, 2013. Shareholders who purchased PAAS stock prior to the ex-dividend date are eligible for the cash dividend payment. This represents an 150% increase over the prior quarter.
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For more information on the declaration, record and payment dates, visit the PAAS Dividend History page.


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Why do I feel like a monster?
View Single Post
Senior Member
Join Date: Jun 2012
Posts: 3,497
I mean this in a kind but firm way, ok? I am not criticizing or judging!
Why do you feel yucky? I think maybe because several times you went back to a relationship that was not feeding you in the past. That was not self respecting behavior and you are starting to see that/come to terms with that. Dealing with your being disappointed in the relationship, dealing in the break up feelings that come with ending a relationship, and dealing with takign stock of your own behaviors. You are in this "review space" frame of mind -- and it's a big thing to have to digest.
But don't take ownership of all the problems here being all YOU. Some yes, but some... this dude sounds messed up. Ack.
When you stated needs that were not being met, he flipped it on you like "you are not ok with polyamory" so it could be
problem. Rather than him owning your feedback as "You are not ok with HIS BEHAVIOR right now." Has nothing to do with polyamory. Has everything to do with loving/kindness type behaviors being shown/not shown BY HIM. And him not wanting to own that or change it and you having to deal with that.
Never mind the wife laundry list. I wonder if she's being mistreated herself.
When you wanted to break up for your own best health...
Shortly thereafter, I told him I thought it would be best to break up. It was really hard for me. I really didn't want to, but the whole situation was just too crazy and chaotic.
He ignores your limit...
He said he thought we needed a "temporary separation" and we could come back together later. He also said he thought it'd be ok for us to still get together, fool around, or even have sex during this time. I didn't ask... those came out of his mouth unbidden.
And when he trespasses upon you, and shows up at your door...you do not enforce consequence by saying "No. I am not seeing you. I did not agree to that arrangement. Shoo." You do not leave the door closed -- but open the door and let him in.
Since then, little has changed aside from not having sex.
Again, not choosing YOU and your best healths. Not choosing self-respecting behavior here. You could choose to apply principle 1 to yourself -- your own inherent, worth, dignity and value. If he comes over, why bother to open the door? Remember you broke up with him?
I am not hearing you changing phones and emails, I am not hearing you telling him to cease and desist all contact.
So... he does not respect you and show you respectful behavior. You do not respect you and show you respectful behavior either. You say you want to leave but do not choose to behave like you have left. It's nice to want to be on good terms with an ex, but... This could be a case where you cannot be friends with this man
and still be in good health yourself!
He's give an inch take a miler type? Well... you cannot force him to change his ways. But you can walk away from him and stop associating yourself with him.
Put your own oxygen mask on, YOU look out for your healths and safety.
You have that responsibility to yourself.
Of course you are going to feel yucky. This is a lot to be dealing with.
To move it out of the yucky zone... You could choose to take better care of you and choose better behavior toward you.
I'm UU, and I don't behave this way. I am poly and I do not behave this way. This guy is behaving in abuser-y sounding ways to me. At the very least, in some seriously disrespectful ways. His wife is suicidal and his exGF is PTSD person and he does WHAT? Care for them appropriately? Respect boundaries/tiggers? Or futz about with his own wants? (And it is alarming he is a youth advisor too. Ugh.)
Please consider checking out
the website
and esp clicking the image for the
larger speak out loud list
in case anything else rings a bell. If it does, still leave but do it safely.
You see it is unhealthy. That is good. But I sincerely hope you are not being abused. I hope you are safe and
can safely WALK AWAY from this guy.
Sometimes the leaving time is a dangerous times and since you have tried to break up and he's not hearing it... I worry about your well being. Some people don't like being given "no" for an answer and escalate things.
Be safe over there, ok? Can you talk to your minister for pastoral care or guidance?
Walk away for your own best healths and break up like you wanted to. But be careful doing it. He's red flagging me too. Sounds weird over there. I am sorry you are dealing with this.
Last edited by GalaGirl; 01-23-2013 at
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URGENT - Soda Makers
I marked this as urgent b/c the Father's Day is the day after tomorrow and I have one particular item on hold at BB&B but I am in dire need of opinions.
When it comes to cold beverages, DH only wants carbonated drinks and hates all others. Honestly, I prefer them as well.
For years, he's been bying carbonated water from Kroger and either drinking it by itself or mixed with juice. I did not think much of it (hey, better than drinking beer, right? LOL) till I realized the danger of plastic bottles (the water might have been in those for a long time) and the fact that it might have been nothing but tap water (I have read some research articles).
I have looked into Soda Makers but the reviews are very mixed. They are crazy expensive when the cost of the replacement chargers is factored in, so the price will probably be comparable to store-bought water and we will not be saving money.
However, I hate that our recycling bin is always "over-flowing" with those - bad for the environment - plastic bottles as well as the fact that we are probably getting BPA and what's not from them.
So, I'd like to now if anyone here uses a Soda Maker. If so, which one? Do you recommend it? What would be a good brand and model?


text:
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15 year old gas direct vent - time to replace?
We have a 15 year old gas zero clearance direct vent FMI unit.
Not sure exactly how much the prior owners used it, but I think quite a bit in the winter.
I can not get a manual and no one here will inspect it w/o the manual.
Is it likely at the end of it's lifespan? Or should we still have a few more years.
We are remodeling, money is tight, but I hate to have to rip it out the new tile and hardwood to replace it in a year or so.
We are also remodeling and have 3 direct vent FPs installed in 1992, rarely used...Majestic brand. (1 in Master BR, 1 in Fam room, 1 in basement). Only working on main floor remodeling now... BR and Fam room. I'm about to head out to a FP store to check out options and am interested to hear any advice out there.
I removed the glass front from 2 of the units and copied down model, serial #s, BTUs, etc. info to take with me to the store today. Also taking photos on my laptop. I went to another store yesterday wihtout that info and without knowing the manufacturer name. Sales person was very helpful yesterday, however, and talked about possibility of refacing versus replacing.... mentioned we needed to have it inspected by a chimney sweep and that it would be worth having an HVAC person 1st see if FP unit could be repaired within reasonable cost before replacing. I appreciated her not trying to sell me a new unit right from the start.
Now that I know the manufacturer, I'm going to a shop who carries the same brand, although if I'm going to start all over, the new shop will have to work hard to impress me more than the lady from yesterday's shop. Will post any new info I learn.
Our DV gas insert is just a couple of years old. We had it serviced for preventive maintenance by the guy who put it in. After removing the glass front, which he cleaned very thoroughly with the kind of cleaner that's used on glass top kitchen stoves, he removed the fake logs and cleaned them. Then he gathered up the fake ashes on the bottom of the firebox and set them aside. Then he vacuumed out the inside of the firebox. Finally, he put the whole thing back together again. He said it should be done every 2 years or so.
I think there are very few or no moving parts in the DV system, so nothing wears out. There is a possibility that the thing they install at the top of the chimney (I think they call it a "chase") might need to be replaced if/when it is eroded by the elements.
I can understand a service guy being reluctant to touch your system without a manual. I would try to find out brand name of your system and then contact the manufacturer. Or you could try to find a specialist who knows direct vent systems and is willing to check yours out.


text:
Steven Orr Spurrier
Position: QB-P
Height: 6-2 Weight: 204 lbs.
Throws: Right
Born: April 20, 1945 in Miami Beach, FL
High School: Science Hill
College: Florida (school history) (Spurrier college stats)
Drafted by the San Francisco 49ers in the 1st round (3rd overall) of the 1967 NFL Draft.
Weighted Career AV (100-95-...): 26 (3800th overall since 1950)
Other SR Links: College Football at Sports-Reference.com
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Output includes all games from 1920 to 2014.


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The Westfield Hall
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Uneventful trip.
... winter
trip, and we had a great time, although I think we were a bit unlucky to catch a spell of not such good weather. We have learnt a lot, like the areas which we like best and which places are likely to get consistently dry warm weather. We tried lots of different campsites and now have an idea which sort best suit our needs.
We enjoyed our month away and will probably do it again next year, bur most likely for a bit longer...... !
Ends today - FREE upgrade to All Inclusive & your tips covered
... and your tips covered if you book today, plus, your 10% Cruise Sale saving is already included in the price. There's sure to be a cruise to tempt. Easter City Getaway ( http://emailfredolsencruises.com/8ID-35 H89-5O3VIU-1GDQA5-0/c .aspx ) 4th Apr 2015 • 7 nights • M1508 Departs Harwich • Braemar Cruise from £630pp* Price includes 10% Cruise Sale discount Tipples & Tapas ( http://emailfredolsencruises.com/8ID-35 H89-5O3VIU-1GDQAJ-0/c .aspx ) 7th Apr 2015 • 7 nights ...
Roadtown Tortola BVI
Another day another island, and beautiful weather yet again as we come in towards Tortola. The good news is that we are the only ship in Roadtown, the bad news is that the new jetty and cruise dock is not yet completed so we are tendering. And for the first time there are complaints! we are not on tour so we decide to wait a while for most people to be off, tendering starts about 8.30 am so at about 10 am we head for the ...
Porchester Castle & Netley Abbey
... many visits. From there we returned to Brockenhurst via Netley Abbey, a former Cistercian site taken over during the Henry VIIIs' dissolution of the abbeys & now a ruin.
Had dinner with John & Caroline Brace at a local pub. Caroline has given up the B & B business & Jaohn is semi retired. They have a beautiful new caravan & plan to spend much of their time travelling with it in ...
Touring Portsmouth & Portchester
... people. Cars are being driven on as the Normandy voyager is a foot and car ferry and we are soon on. We find our cabin get settled and before you know it we are as Rod Stewart sings "sailing". We are thankful that the weather report for our crossing advises smooth seas.
We head down stairs to the refreshment area and there are a lounge chairs that people who have not booked a cabin are sleeping in and if they can't find a ...


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The compound of the formula ##STR1## and its tautomer are obtained from cultures of Eupenicillium sp. The compound has antifungal activity.
1. A compound of formula I ##STR6## ##STR7## its tautomer or a salt thereof.
2. The tautomer of the compound of claim 1 having the formula ##STR8##
3. A method of inhibiting chitin synthase 2 activity in a mammal in need of inhibiting such chitin synthase 2 activity which comprises administering to a mammal a compound of the formula ##STR9## its tautomer or a pharmaceuticaly acceptable salt thereof, in an amount which is effective in inhibiting chitin synthase 2 activity.
4. A pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula ##STR10## its tautomer or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.
5. The pharmaceutical composition of claim 4 wherein the compound is the tautomer of the compound of formula I which has the formula ##STR11## or a pharmaceutically acceptable salt thereof.
6. The pharmaceutical composition of claim 4 wherein the amount of said compound of formula I is about 10 mg to about 400 mg.
7. The pharmaceutical composition of claim 5 wherein the amount of said compound of formula Ia is about 10 mg to about 400 mg.
8. The pharmaceutical composition of claim 4 which is in unit dosage form.
9. The pharmaceutical composition of claim 8 wherein said unit dosage form is selected from the group consisting of tablets, coated tablets, dragees, hard gelatine capsules, soft gelatine capsules, solutions, syrups, and suspensions.
10. The pharmaceutical composition of claim 9 wherein the amount of said compound of formula I in the unit dosage form is from about 10 mg to about 200 mg.
11. A method for treating a mammal having infections caused by fungi which comprises administering to said mammal a compound of the formula ##STR12## its tautomer or a pharmaceutically acceptable salt thereof, in an amount which is effective in treating infections caused by fungi.
12. A method of prophylaxis against the development of fungal infections which comprises administering to a mammal susceptible to such infections a compound of the formula ##STR13## its tautomer or a pharmaceutically acceptable salt thereof, in an amount which is effective as a prophylaxis for fungal infections.
The present invention is concerned with a novel compound (hereinafter referred to as Xanthofulvin) of the formula I ##STR2## or a salt thereof.
Xanthofulvin also occurs in a tautomeric form of the formula ##STR3##
The term Xanthofulvin as used herein refers to both the enol form and the diketo tautomer.
The present invention is concerned with a novel compound (hereinafter referred to as Xanthofulvin) of the formula I, ##STR4## or a salt thereof.
Xanthofulvin also occurs in a tautomeric form of the formula ##STR5##
The term Xanthofulvin as used herein refers to both the enol form and the diketo tautomer.
The present invention is also concerned with the use of xanthofulvin to treat or prevent fungal infections in mammals, humans and non-humans, for use as therapeutically active substances, a process for producing Xanthofulvin, a microorganism capable of producing Xanthofulvin, and chitin synthase 2 inhibiting compositions.
Chitin is a linear homopolymer of N-acetylglucosamine. It is commonly found in fungal cells and widely distributed in almost all fungal genera. Chitin is a minor but an essential cell wall component for fungi and does not exist in mammalian cells. Therefore it has been regarded as one of the most attractive targets for antifungals, though very few inhibitors have so far been found. Polyoxins and nikkomycins are well known as chitin synthase inhibitors hut have not yet found clinical use. However, these compounds still draw much attention since the inhibitory activity against chitin synthase is specific and potent. Recently three chitin synthases of Saccaromyces cerevisiae were identified (chitin synthase 1, 2 and 3) where chitin synthase 2 (Chs 2) proved to be most critical among the three (N. H. Valdivieso, P. C. Mol, J. A. Shaw, E. Cabib and A. Duran. J. Cell Biol. 114, 101-109 (1991); J. W. Shaw, P. C. Mol, B. Bowers, S. J. Silverman, M. H. Valdivieso, A. Duran and E. Cabib. J. Cell Biol., 114, 111-123 (1991)). Polyoxin D and nikkomycin X were found to inhibit chitin synthase 1 (Chs 1) rather than Chs 2 (E. Cabib. Antimicrob. Agents Chemother., 35, 170-173 (1991))
In accordance with the present invention it has been found that some specific microorganisms produce Xanthofulvin having high Chs 2 inhibiting activity.
The physico-chemical properties of Xanthofulvin obtained as described in the Example given hereinbelow are as follows:
______________________________________Appearance: Yellow crystalsMelting point: 249�251� C. (dec.)Molecular formula C28 H18 O14*HRFAB-MS (m/z) (M + H)+ :Calcd.: 579.0775Found: 579.0786UV λmax nm (ε):in MeOH 239 (33,600), 317 (20,400), 400 (17,800)in MeOH/1N HCl (100:1) 240 (30,900), 313 (25,000), 365 (17,900)in MeOH/1N NaOH (100:1) 233 (35,400), 383 (31,000)IR νmax (KBr) cm-1: 3430, 1700, 1600, 1480, 1360, 1280Solubility: Soluble in DMSO, MeOH Slightly soluble in H2 O Insoluble in n-hexane1 H NMR (400 MHz, 2.37 (3H, s), 2.72 (3H, s),CD3 OD/CDCl3 /DMSO-d6 4.67 (2H, br s), 6.43 (1H, s),(2:1:1) used TMS as an 6.97 (1H, s), 8.03 (1H, s)internal standard)δ:13 C NMR (100 MHz, 16.8, 32.4, 66.6, 102.9, 103.5,CD3 OD/CDCl3 /DMSO-d6 104.9, 110.3, 110.8, 119.2, 120.2,(2:1:1) used TMS as an 121.1, 126.6, 130.0, 132.6, 139.1,internal standard)δ: 139.3, 141.6, 151.0, 152.4, 154.1, 154.7, 156.5, 168.6, 168.8, 171.1, 173.6, 184.4, 202.5______________________________________ *HRFAB-MS: High Resolution Fast Atom Bombardment Mass Spectrometry
According to the process provided by the present invention, Xanthofulvin is produced by cultivating a microorganism belonging to the genus Eupenicillium capable of producing Xanthofulvin under aerobic conditions in an aqueous culture medium and isolating Xanthofulvin from the culture.
The microorganism used in the foregoing process can be any strain (including variants) belonging to the genus Eupenicillium capable of producing Xanthofulvin. Especially preferred strains are Eupenicillium sp. NR7125 as well as variants thereof. Eupenicillium sp. NR7125 was directly isolated from a fruiting body of Marasmius sp. collected in Hachijo-jima Island, Tokyo, Japan, and identified as a strain belonging to the genus Eupenicillium.
The strain denoted as Eupenicillium sp. NR7125 has been deposited with the Fermentation Research Institute, Agency of Industrial Science and Technology, Japan, under the Budapest Treaty on Sep. 30, 1991 as follows: Eupenicillium sp. NR7125 (FERM-BP No. 3588).
The cultural characteristics and the morphological characteristics of Eupenicillium sp. NR7125 (FERM-BP No. 3588) are as follows:
On Czapek-Yeast extract agar (CYA), colonies grew rapidly attaining a diameter of 42-45 mm in 7 days at 25� C., showing floccose in appearance and furrowed in a radiate pattern. Mycelium is white. The conidiogenesis and ascocarp formation were not prominent so that it could not affect the color of the colonies. Exudates or soluble pigments were not produced. Reverse was in pale yellow (Cream Yellow, Munsell, 2.5Y9/4).
On malt extract agar (MEA), colonies grew rapidly to reach 37-40 mm in diameter after 7 days, showing floccose appearance. Mycelium was white. Conidiogenesis was prominent particularly in the central area of the colonies, showing soft blue green (Munsell, 2.5BG7/4). Abundant ascocarps were formed on the surface of the agar. Exudates or soluble pigments were absent. Reverse was pale yellow (Cream, Munsell, 5Y9/2).
On 25% glycerol-nitrate agar (G25N), colonies grew slowly showing compact and velutinous, and reached 16-17.5 mm in diameter in 7 days at 25� C. Conidial production was not prominent. Mycelium was white. Reverse was cream yellow. Pigment in agar was absent.
On CYA at 37� C., colonies grew rapidly attaining a diameter of 29-33 mm.
Conidiophores were born from surface hyphae or aerial hyphae, smooth and thin walled, typically long and slender of 100-250 μm in length. They usually terminated in a verticil of 3-5 phialides (monoverticillate), but sometimes with one or two, rarely three metulae (biverticillate). Metulae were mostly long and divergent, 10-20�2-3 μm. Phialides were ampulliform, 8-12 �2-3.5 μm, and abruptly tapered to the apical conidium bearing part. Conidia were most often Subglobose, 2.9-3.6�2.7-3.3 μm with finely roughened to verrucose walls, and born in short chain. Ascocarps were pseudoparenchymatous cleistothecia, 100-250 μm in diam., becoming white to cream, texture sclerotioid but soft, maturing in 3 weeks. Asci were born singly, ellipsoidal, 8.4-11.7�6.8-7.2 μm. Ascospores were hyaline, subspheroidal to broadly ellipsoidal, 2.9-3.5�2.6-3.1 μm, with walls echinulate but without flange.
Ascocarps were sclerotioid and surrounded by pseudoparenchymatous walls. Penicillium-anamorph was readily observed on CYA and MEA. These characteristics clearly indicated that this strain, NR7125 (FERM-BP No. 3588) was included in the genus Eupenicillium Ludwig. Therefore, this strain was identified as Eupenicillium sp. NR7125.
The cultivation in accordance with the process provided by the present invention can be carried out in a culture medium which contains customary nutrients usable by the microorganism being cultivated. As carbon sources there can be mentioned, for example, glucose, sucrose, starch, glycerol, molasses, dextrin and mixtures thereof. Nitrogen sources are, for example, soybean meal, cottonseed meal, meat extract, peptone, dried yeast, yeast extract, cornsteep liquor, ammonium sulphate, sodium nitrate and mixtures thereof. Moreover, there may be added to the culture medium other organic or inorganic substances for promoting the growth of the microorganism and for increasing the production of Xanthofulvin, examples of such substances being inorganic salts such as, for example, calcium carbonate, sodium chloride, phosphates and the like.
The cultivation is carried out under aerobic conditions in an aqueous medium, preferably by submerged fermentation. The cultivation is suitably carried out at a temperature of 20�-35� C., the optimal temperature being 27� C. The cultivation is preferably carried out at a pH of 3 to 9. The cultivation time depends on the conditions under which the cultivation is carried out. In general, it is sufficient to carry out the cultivation for 50�200 hours.
The isolation of Xanthofulvin from the fermentation broth can be carried out according to methods known per se. For example, the mycelium can be separated from the fermentation broth by centrifugation or filtration and Xanthofulvin can be extracted from the filtrate with a water-immiscible organic solvent such as alkanol e.g. n-butanol and esters e.g. ethyl acetate, butyl acetate etc. On the other hand, Xanthofulvin contained in the separated mycelium can be obtained, for example, by extracting the mycelium with a solvent such as aqueous acetone or aqueous methanol, removing the solvent and further extracting the residue with a water-immiscible organic solvent. The thus-obtained solvent phase is dried with a dehydrating agent such as sodium sulphate etc. and then concentrated under reduced pressure. The resulting crude Xanthofulvin can be purified by means of extraction methods, partition methods, precipitation methods, column-chromatographical methods (using silica gel, aluminium oxide etc. as adsorbants) or by means of molecular sieve methods.
Xanthofulvin is isolated as a free acid, but this can be, if required, converted into pharmaceutically acceptable salts such as sodium salt, potassium salt and calcium salt by conventional methods.
Inhibitory activity of Xanthofulvin against Chs 1 and Chs 2 from Saccharomyces cerevisiae was measured respectively.
The overproducer employed for Chs 1 was Saccharomyces cerevisiae (ura3) harbouring plasmid (CHSl, URA3). The cells were permeabilized with 0.5% digitonin for 15 min at 30� C., followed by treatment with trypsin at the final concentration of 100 μg/ml for 15 min at 30� C. After addition of trypsin inhibitor from soybean, 50 μl of 2.5�107 cells/ml was incubated for 1 hr at 30� C. with 40 μl of assay solution containing 50 mM MES pH 6.5, 5 mM Mg(OAc)2, 32 mM N-acetylglucosamine and 0.1 mM [14 C]-UDP-N-acetylglucosamine, and 10 μl of sample solution. Reaction was terminated with addition of TCA and cells are collected on the filter and washed with 70% aqueous ethanol containing 0.3M acetic acid. Radioactivity of cells is counted with a liquid scientillation counter. Amount of chitin formed was determined on the basis of radioactivity incorporated into the cells (S. J. Silverman, A. Sburlati, M. J. Slater and E. Cabib. Proc. Natl. Acad. Sci. USA, 85, 4735-4739 (1988)). Inhibitory activity of Xanthofulvin against Chs 1 was shown in Table 1.
Overproducer for Chs 2 was a Saccharomyces cerevisiae strain of disrupted Chs 1 gene (chs1:: URA3, leu2 ) with plasmid (CHS2, LEU2). Assay method was the same as the one for Chs 1 described above except for assay solution. Assay solution for Chs 2 contained 30 mM Tris (pH 7.5), 2.5 mM Co(OAc)2, 32 mM N-acetylglucosamine and 0.1 mM [14 C]-UDP-N-acetylglucosamine (See: Silverman et al. supra). Inhibitory activity of Xanthofulvin was shown in Table 1.
TABLE 1______________________________________ IC50 (μM) Chs 1 Chs 2______________________________________Xanthofulvin >200 2.2polyoxin D 0.26 10.3______________________________________
As shown in the above Table 1, Xanthofulvin has high Chs 2 inhibiting activity. Thus, Xanthofulvin can be used as an antifungal agent, e.g. for the treatment of or prevention of infections with Candida sp. (candidoses).
Acute toxicity of Xanthofulvin is not observed.
The novel Xanthofulvin and salts thereof provided by the present invention can find use as medicaments, for example in the form of unit dose pharmaceutical preparations which contain them or their salts in admixture with an organic or inorganic inert carrier material suitable for enteral application, such as for example water, gelatine, gum arabic, lactose, starch, magnesium stearate, talc, vegetable oils, polyalkylene glycols etc. The unit dose pharmaceutical preparations can be present in solid form, e.g. as tablets, coated tablets, dragees or capsules, hard gelatine or soft gelatine, or in liquid form, e.g. as solutions, syrups, or suspensions.
A dose unit may contain 10 to 200 mg of active ingredient. The daily dosage for an adult can be in the range from 10 to 400 mg and may be varied according to individual requirements which can be determined by those of ordinary skill in the art.
The following Example further illustrates the present invention.
The spore suspension from well grown slant of Eupenicillium sp. NR7125 (FERM-BP No. 3588) was inoculated into a 500-ml Erlenmeyer flask containing 100 ml of the medium consisting of glucose 2%, glycerol 3%, Polypeptone (Nippon Seiyaku) 0.5%, Yeast extract (Nippon Seiyaku) 0.2%, NaCl 0.3% and CaC03 1%. The flask was shaken at 220 rpm for 3 days at 27� C. Two ml of the resultant culture was each transferred to fifty 500-ml flasks containing the same medium above. The fermentation was conducted on a rotary shaker at 220 rpm at 27� C. After 5 day cultivation, the culture broth was subjected to the isolation procedure described below.
The culture broth (5 liters) was separated into filtrate and mycelium by centrifugation. The culture filtrate (3.2 liters) was extracted with 2 liters of n-butanol at pH 9.0, and the organic layer was discarded. The aqueous layer (3.1 liters) was then extracted with 5 liters of n-butanol at pH 2.0, and the organic layer was concentrated under reduced pressure. The concentrate (24.1 g) was dissolved in 1 liter of methanol and partitioned with 2 liters of n-hexane. The methanol layer was then concentrated to dryness under reduced pressure, and the residue (24 g) was triturated with 50 ml of methanol. After removal of the precipitates by filtration, the filtrate was subjected to a column chromatography on 10.5 liters of Sephadex LH-20 (Pharmacia) using methanol as an eluent. The active fractions were combined and concentrated under reduced pressure to give a yellowish powder which was crystallized from methanol to give 32 mg of Xanthofulvin as yellow crystals.
The following example illustrates a pharmaceutical preparation containing Xanthofulvin provided by the present invention:
Tablets each containing the following ingredients were manufactured in the conventional manner per se:
______________________________________Xanthofulvin 100 mgStarch 26 mgCarboxymethylcellulose calcium 15 mgCrystalline cellulose 20 mgMagnesium stearate 4 mg 165 mg______________________________________
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|District News
|Jan 23, 2015 For parents who would like their child to be more successful on the new M-Step test (taking the place of MEAP) online, this link will take you to a practice test that will get students prepared for the online exams. It may be taken as many times as you want. Click here to learn more (Only works with Chrome Browser). Test Prep for Spring Tests
We're proud to offer diverse, innovative programs for students and to celebrate our points of pride which set us apart from all other districts in the area. With our dedicated staff, safe and friendly community and excellent facilities, Eaton Rapids Public Schools are the best place for your child.
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Check out our 3 kWh solar panels collect energy and offset our electric bill and lower our carbon footprint.
Kindergarten Round-Up 2015-2016! March 11 or 24 at 6:30pm.
Celebrate with us as we honor our hardworking, bright shining stars!
There are openings in the Great Start Readiness Program, for you preschooler who will be four years old by October 1, 2014. The program is free to children who are eligible.
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"I don't know a single Jewish
Submitted by AntiFed1791 on Mon, 03/04/2013 - 14:37. Permalink
"I don't know a single Jewish person who has ever read it. EVER."
lol how ignorant are you? And you have the nerve to ask if I've spoken with a Rabbi?
"Keep repeating these lies about Jews and the Talmud. It makes you far lower and more evil than them for knowingly spreading lies."
I know you are, but what am I?
"The United States can pay any debt it has because we can always print money to do that." — Alan Greenspan
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Hello my friends i have one zte racer II P728B with lock code.How reset it this?
How can flashing this phone?
XDA Developers was founded by developers, for developers. It is now a valuable resource for people who want to make the most of their mobile devices, from customizing the look and feel to adding new functionality.
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Having bought a robot hard-floor 'vacuum' cleaner I decided that making a short video of it in use would be a good way to learn how to use the Sony Vegas Movie Studio software. The software came with a 'how-to' movie on DVD so having a dual screen computer setup I was able to follow instructions as I worked. I've been using Adobe Premier & Serif Movie Plus before now and all three progs have their pros and cons but the big pros for Sony are the smoothness of previews, ease of frame selection and use of effects tools from a right-click menu.
As for the robot cleaner - it does a great job, especially in getting into (and out of) tight corners.
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Comment: Re:Ikea (Score 2) 62
No. It's just complaining. No one buys furniture because they enjoy easy 3D puzzles. Assembly is an annoying extra hill to climb.
We've improved Slashdot's video section; now you can view our video interviews, product close-ups and site visits with all the usual Slashdot options to comment, share, etc. No more walled garden! It's a work in progress -- we hope you'll check it out (Learn more about the recent updates).
No. It's just complaining. No one buys furniture because they enjoy easy 3D puzzles. Assembly is an annoying extra hill to climb.
It's about time the people displaced by Ikea's relentless territorial expansion found shelter.
The intelligence services are together with the President and his staff. They don't get to claim they're independent. If you want independence from your boss' misdeeds, resign. If you want independence from your underlings' misdeeds, fire them.
So the argument is that they're useful enough to be somewhat worthwhile but not useful enough to make the threat to Germany a serious one? I'm not sure how that could ever make them "the good guys". Are we grading on a curve?
Acting in your own interest is one thing. Acting in the interest of spite is another.
This is a poor argument even by internet standards. If they never prevent anything, they're not "the good guys" because they're spying on people for no reason. If they do prevent attacks, they just threatened to allow Germany to be attacked for spite.
versus who else? (It's hard to follow unstated reasoning.) And why does it matter? The intelligence agencies are a party to the threat, even if they didn't say the words themselves.
It does confirm one thing: the US intelligence agencies aren't "the good guys". The good guys wouldn't condemn Germany to suffer otherwise preventable terrorist attacks for spite. Thanks to Germany for confirming this and making it known to all.
That will never happen.
I guess there's no point in talking about it then. Knowing the future must make reading the news a little boring for you.
Denying people the ability to acquire weapons is meddling. Any kind of trade could also be called meddling, or refusing to trade. But if you trade goods, including weapons, without choosing sides, locals get to choose their own path.
It's up to the locals to do that. Locals need to choose things like rule of law, free markets, and popularly elected government. Otherwise it can't be sustained. The things that outsiders can do are:
- stop meddling
- show a positive example -- like Botswana
- trade
- don't deny weapons and ammunition to people who need them to protect themselves
TV does not offer a company like Apple much opportunity. There's no UI problem that keeps people from being able to get the most value out of their TV. People won't buy an easy to use TV at a big premium over a regular TV. This is why Apple was never going to make a TV.
The only thing people really want from their TV is cheaper, more conveniently delivered content. Apple has no TV content, and there's no way for Apple to make money offering others' TV content at a cheaper price. And there's no way to sell a new premium TV based on cheaper TV content -- the premium you gained on the TV would be more than lost on the content discount.
Natural gas is so cheap and so abundant in the US that wind power makes zero financial sense as a competitor. If wind actually does double, it will be a huge misallocation of resources.
And it won't really help the environment. The natural gas will just be burnt off or vented to the atmosphere instead of being captured to produce electricity.
Let's outsource the boss fights.
From the we-don't-really-know-how-radios-work dept.
Thrashing is just virtual crashing.


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Ryvita Sweet Onion
by Ryvita
Submitted by dancingvoice
DailyBurn Tracker's large food database contains 937,000 foods with detailed nutrition labels. After you sign up for a FREE account you can keep your own food journal and easily meet your health and dieting goals!
Nutrition Facts
|Serving Size
|1 Ryvita
|Amount Per Serving
|% Daily Value*
|Total Fat
|0.2 g
|0 %
|Total Carbohydrate
|9 g
|3 %
|Dietary Fiber
|2 g
|6 %
|< 1 g
|1.1 g
|2 %
|* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.


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Dr. Pamela C. Sisney, MD
Podiatric Medicine
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Cincinnati, OH 45255
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- (513) 474-4450
Dr. Sisney works in Cincinnati, OH and 1 other location and specializes in Podiatric Medicine. Dr. Sisney is affiliated with Bethesda North Hospital, Christ Hospital, Mercy Hospital Anderson and UC Medical Center.
Gender: Not Available
Languages Spoken: English
Podiatric Medicine
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*This physician has multiple office locations. See Office Information for details.


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Yamaha YZF-R1 read trouble codes
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Maxiscan MS309 OBD2 Can Eng/Fr/Sp/Dutch/G ScannerMS309 CAN OBDII Code Reader provides easy and quick access to Diagnostic trouble codes for all OBDII compliant vehicles sold worldwide since 1996. It shows code definition on screen. Though small in size, it is powerful enough to retrieve same information as large expensive scanners. Learn More$19.99
MaxiDiag Elite MD802 all system+DS model
Autel' new MaxiDiag Elite Series, the most advanced and multifunctional scan tools powered by its exclusive technology, are designed for technicians to troubleshoot either the basic four systems or all the systems for most of major vehicles on the road today. This new diagnostic platform delivers fast and easy diagnostics at the right price.Learn More
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U480 OBD2 CAN BUS Code Scanner OBDII Engine Code Readermemoscan U480 code reader enables you to read and erase the fault codes that related to CHECK ENGINE LIGHT and turn off the light. It works on all OBD2/EOBD compliant vehicles including CAN BUS vehicles. Learn More$28.90
V-CHECKER VCHECKER V301 OBD2 Professional CANBUS Code ReaderV-checker V301 is mainly developed for diagnosing engine system of OBD compliant cars. It supports all OBD standard tests and adds original decoding function for some vehicles. Learn More$87.99
VAG DASH CAN Version 5.05 New versionVAG DASH COM+CAN V5.05 main function: recalibrate the odometer add keys to the car even though you don't have all existing keys available read out trouble codes of CAN-ECU and erase them. Learn More$148.99
C100 Auto Scan OBDII/EOBD Code ReaderC100 code reader works on all 2001 and later OBDII compliant PETROL European vehicles, works on all 2004 and later OBDII compliant DIESEL European vehicles and works on all 1996 and later OBDII compliant US and Asian vehicles. C100 scanner supports giving you the definition of the trouble code. Learn More$48.50
CAN OBDII Code Reader MaxiScan® MS300Autel MaxiScan® MS300 CAN OBD2 fault code scanner supports all OBD II protocols, including the newly released Controller Area Network (CAN) protocol. Buy Autel MaxiScan® MS300 scanner from obd2-diagnostic.com at cheap price and offered with free technical service. Learn More$29.70
HONDA/ACURA Professional Tool H685Memoscan H685 Honda Acura fault code reader can test and erase the car trouble codes and read the relative trouble codes. Many mechanical problems, such as poor engine performance due to low fuel level, damaged soft cube, electrical wire or electrical connectors, can also cause faked trouble codes. Learn More$159.50
MemoScan VAG5053 VW AUDI Scanner Service ResetMemoscan VAG5053 obdii code scanner is a powerful, affordable handy scanner designed for all VW, AUDI, SKODA, & SEAT vehicles (supports CAN-BUS). VAG5053 obdii code scanner is small in size, robust in design, competitive in price & easy to use. This is a stand alone unit; it does not need a laptop to operate. Learn More$87.50
VT8 VW AUDI Autodigital SRS ToolVT8 VW AUDI Autodigital SRS Tool used for vag car model airbag reset, repair and clear trouble codes. Learn More$219.99
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Autel Maxidiag Elite MD704 for 4 System Update InternetAutel Maxidiag Elite MD704 for 4 system update internet, Diagnose Peugeot,Citroen,Renault,Dacia,Fiat,Abarth,Alfa-Romeo,Maserati,Lancia,EU Ford Learn More$249.99
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Professional Scan Code Reader U695 for Japanese CarU695 Scanner not only can be used for Japanese vehicle which apply OBD2 protocols, but also can be used for old Honda 3pin car model and old Nissan 14pin car model. It is a powerful hand-held Japanese vehicle diagnostic tool. Learn More$168.50
BMW Commander 5.4 Versionabrites commander for bmw is a PC - Windows based diagnostic software for dealer level access to the vehicle (identification, trouble codes and s.o.), mileage correction, key programming, programming vehicle order. Tool can access CAS1 and CAS2 by OBDII. CAS3 by cas-connector. Learn More$0.00
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Original Autel AutoLink AL439 OBDII/CAN and Electrical Test ToolThe AutoLink AL439 OBD II/EOBD Scanner supports all 10 modes of OBD II test for a complete diagnosis. Featuring the unique patented One-Click I/M Readiness Key, circuit test, starting and charging systems test, TFT color display, built-in speaker , the versatile, easy-to-use AL439 will streamline automotive service and help ensure rapid, accurate diagnosis and timely repair. Learn More$164.99
Autel MaxiService VAG505 VW AUDI SEAT SKODA Scan ToolThe MaxiService VAG505 scan tool is an OEM level diagnostic tool for most VW/ Audi/ Seat/ Skoda vehicles sold worldwide since 1996. Using Volkswagen proprietary diagnostic protocol, VAG505 allows the user to access almost all the systems. Small, robust, affordable and easy to use, it is the "Electronic Wrench" you should keep in your glove box! Learn More$192.49
ELM 327 1.5V Version USB CAN-BUS Scanner ELM327 SoftwareOBD-II Software for ELM327 USB is a free program that allows you to use your PC and a hardware interface to get the information from your car's computer. The program is very user-friendly, and easy to learn. It is also very easy to install: simply extract the files into a folder on your computer's hard drive, and you're ready to go. To uninstall the program, simply delete the entire contents of the folder where the program resides. The software supports two platforms - DOS and Windows. Learn More$22.90
U380 OBDII OBD2 EOBD Engine Scanner Trouble Code ReaderMemoscan U380 scanner is a kind of auto device for reading and erasing trouble code in vehicles, sometimes called car reader. Though so small, light and handy, which is dynamic and fashionable in design, competitive in price and easy to use. Learn More$36.90
ELM327 Bluetooth software OBD2 EOBD CAN-BUS Scanner ToolELM327 Bluetooth CAN-BUS scan tool supports all OBD-II protocols.It is used to read diagnose trouble codes,clear trouble codes and detect fuel pressure and so on. Learn More$26.50


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Siam Sawasdee
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Delivery vol.2
Что непри 03;тно – непри 03;тно получ
77;ние доков в укр посол 00;стве.
Суть в чем, в роддо 84;е ...
Pattaya Na Klua
... again tomorrow when it's day time, there is actually a very nice beach which I had not seen when I walked around earlier and I think what I mistook to be pollution was actually silt from a nearby river existing into the sea. In the evening, headed out to Walking Street, a notorious nightlife area, with the two lads and did some walking and some drinking, then having walked past a group of lady boy bars one of them said he had lost his wallet, I.e. it had been nicked. The ...
A Week in Pattaya
... I could get into the condo system from our room so that has been a bonus over the last few days. We will go back into town this afternoon for a last look at a big shopping complex we saw last night and then it will be back to pack for an early start as our taxi is booked for 5am. We fly out on Air India to Delhi for a 2 hour stopover before on to London for 1 night and then it's Eurostar to Barcelona on Tuesday - arriving Wednesday morning. See you in Spain! ...
Open water divers
... Open Water Diving qualification, it was something we had both wanted to do for a while. We only had 5 days holiday from school, so we chose Pattaya as it was the quickest and easiest place to get to from Dhaka. Pattaya isnt somewhere I would choose for a relaxing holiday... think Blackpool... just in Thailand!! However it has good diving and with time limitations it was perfect for what we needed.
Our second day was ...
Pattaya, you wouldn't believe it....
... old, fat white guys walking around with pretty young Thai girls, don't go to Pattaya". How true….lot's of Scandinavians, Germans, Russians and some Americans keep the sex tourism business alive. This sexual tourism industry was started during the Viet Nam war by US servicemen on r&r. Another fine legacy that we Americans can be proud of…. We passed bar after bar after bar with far too many scantily ...


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What's GNU: Bash—The GNU Shell
The lesson that has been repeated most often during bash development is that there are dark corners in the Bourne Shell, and people use all of them. In the original description of the Bourne shell, quoting and the shell grammar are both poorly specified and incomplete; subsequent descriptions have not helped much. The grammar presented in Bourne's paper describing the shell distributed with the Seventh Edition of Unix is so far off that it does not allow the command who|wc. In fact, as Tom Duff states:
"Nobody really knows what the Bourne shell's grammar is. Even examination of the source code is little help."1
The POSIX.2 standard includes a yacc grammar that comes close to capturing the Bourne shell's behavior, but it disallows some constructs which sh accepts without complaint-and there are scripts out there that use them. It took a few versions and several bug reports before bash implemented sh-compatible quoting, and there are still some "legal" sh constructs which bash flags as syntax errors. Complete sh compatibility is a tough nut.
The shell is bigger and slower than I would like, though the current version is faster than previously.
The readline library could stand a substantial rewrite.
A hand-written parser to replace the current yacc-gener-ated one would probably result in a speedup, and would solve one glaring problem: the shell could parse commands in "$(...)" constructs as they are entered, rather than reporting errors when the construct is expanded.
As always, there is some chaff to go with the wheat. Areas of duplicated functionality need to be cleaned up. There are several cases where bash treats a variable specially to enable functionality available another way ($notify vs. set -o notify and $nolinks vs.
set -o physical, for instance); the special treatment of the variable name should probably be removed. A few more things could stand removal; the $allow_null_ glob_expansion and $glob_dot_filenames variables are of particularly questionable value. The $[...] arithmetic evaluation syntax is redundant now that the POSIX-mandated $((...)) construct has been implemented, and could be deleted. It would be nice if the text output by the help builtin were external to the shell rather than compiled into it. The behavior enabled by $command_oriented_history, which causes the shell to attempt to save all lines of a multi-line command in a single history entry, should be made the default and the variable removed.
As with all other GNU software, bash is available for anonymous FTP from prep.ai.mit.edu:/pub/gnu and from other GNU software mirror sites. The current version is in bash-1.13.5.tar.gz in that directory. Use archie to find the nearest archive site. The latest version is always available for FTP from bash.CWRU.Edu:/pub/ dist. bash documentation is available for FTP from bash.CWRU.Edu:/pub/bash.
The Free Software Foundation sells tapes and CD-ROMs containing bash; send electronic mail to firstname.lastname@example.com or call +1-617-876-3296 for more information. bash is also distributed with several versions of Unix-compatible systems. It is included as /bin/sh and /bin/bash on several Linux distributions and as contributed software in BSDI's BSD/386 and FreeBSD.
bash is a worthy successor to sh. It is sufficiently portable to run on nearly every version of Unix from 4.3 BSD to SVR4.2, and several Unix workalikes. It is robust enough to replace sh on most of those systems, and provides more functionality. It has several thousand regular users, and their feedback has helped to make it as good as it is today-a testament to the benefits of free software.
1 Tom Duff, "Rc-A Shell for Plan 9 and UNIX systems", Proc. of the Summer 1990 EUUG Conf., London, July, 1990, pp. 21-33
2 BSD/386 is a trademark of Berkeley Software Design, Inc.
Chet Ramey (firstname.lastname@example.com) is a programmer at Case Western Reserve University and volunteer at the Free Software Foundation.
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text: Casper Police Dept. [ Rita Palato Pleads Not Guilty To Knife Assault Charges By Kevin Koile July 23, 2013 A Casper woman has denied in court that she stabbed a man. Read More|Comment Category: Casper News, Crime Tags: aggravated assault, possession of a deadly weapon with unlawful intent, Rita Palato Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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U.S. Economic Growth Regained Speed In First Quarter
Listen to the Story
36 sec
Gross domestic product grew at an annual rate of 2.5 percent. Consumer spending is up, and home construction rose. But government spending fell, and tax increases and federal budget cuts are expected to slow later this year.
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Control the number of windows instances for your app.
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Become more proficient on the usage of statements to control the flow of execution through a C++/CLI application.
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Learn how to use .NET code to configure email. There's one "gotcha," but it's thoroughly explained.
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Visual Basic gives you plenty of tools to work with external windows. Here, we manipulate Notepad.
Maker Project: Creating a Garage Door Opener
Have you ever wanted to control your garage door from your smartphone? Here is your chance. Get your hands dirty with an Arduino Garage Door Controller.


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WolverineNation Mailbag
February, 29, 2012
By Chantel Jennings | ESPN.com
Lon Horwedell/Icon SMISophomore Frank Clark, along with Brennen Beyer, is expected to give Michigan more of a pass-rushing element from the defensive end position next season.
We're well into spring break for Michigan students. But the basketball team is still around and the fans don't get a spring break, so we know you have questions.
And we love hearing from our readers. Michael will be handling next week's mailbag so if you have any questions send them over to firstname.lastname@example.com.
Q: @Showboat804 via Twitter: If Michigan has a terrible season next year how will [Michigan coach Brady Hoke] keep this recruiting class together?
CJ: I don't think that'll be a problem. Hoke put together much of last year's No. 7 class in the country without so much as a game under his belt as a Michigan coach (though he closed it out as a BCS bowl game champion). If the team does poorly that could act as a positive for many young players because they could see the potential for playing time (especially with so many four stars already committed). Also, it's not just Hoke holding this class together. Several of the 2013 commits have already begun trying to establish a family-like feel in their class.
Q: Art Vandelay via Twitter: U of M lacked an edge rusher last season. Who's the favorite to get pressure this year, and who are they targeting for this for 2013?
CJ: Last year it would've been Craig Roh, who's likely moving to the other side of the line. But I think this season someone like Brennen Beyer might drop down from linebacker to defensive end, giving Michigan an athletic pass rusher. Frank Clark saw some playing time as a freshman and should be another piece to Michigan's pass rush puzzle. Part of the Michigan coaches' goal has been to add speed at this position, which they did in the 2012 class with Mario Ojemudia. One of Ojemudia's biggest strengths is his speed off the edge, so he'll have a chance to get some time early. They have also already addressed that need in the 2013 class by adding Taco Charlton. At 6-foot-6, 235 pounds Charlton has a lot of athleticism and size that is highly wanted at his position.
Q: Van Shumake via Twitter: Why are U of M fans arrogant & think their school has the "winningest" record when early on they played inferior opponents?
CJ: I think arrogance is in the eye of the beholder, so it's not really an objective question. And Michigan fans don't just think Michigan is the winningest program -- it is. The Wolverines have amassed 895 wins over their 132-year history (that's 6.8 wins per season). And it's not that they played inferior opponents in the beginning. The Wolverines had a solid coach for the first two decades of their program. Fielding H. Yost invented the forward pass, changing the game and making defenses completely unsure of how to defend. In 1901, the Wolverines outscored opponents 550-0. In 1902 it was 644-12. It's not that they were playing terrible teams. They were very good early on and it gave them some cushion in the later years when everyone began catching up.
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Michigan C Cites Concussions In Decision To Quit
Thursday, 9/3
Friday, 9/4
Saturday, 9/5
TBD Southern Illinois Indiana TBD Illinois State Iowa TBD Richmond Maryland TBD BYU Nebraska TBD Norfolk State Rutgers TBD Penn State Temple TBD Wisconsin Alabama TBD Stanford Northwestern
Sunday, 9/6
3:00 PM ET Purdue Marshall


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Sci-fi and fantasty. Not many favourite movies. Music wise, trance/techno, rock, classical, metal, ambient, etc. No country/hiphop/rap.
MEAT. But not fish.
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Rocket still centerpiece as NKoreans mourn Kim
PYONGYANG, North Korea PYONGYANG, North Korea (AP) - North Korea parlayed the success of last week's rocket launch to glorify leader Kim Jong Un and his late father on Sunday, the eve of the first anniversary of his death.
The successful firing the rocket on Wednesday - ostensibly to place a satellite in space - was a clear sign that Kim will continue carrying out his father Kim Jong Il's policies even if they draw sanctions and international condemnation.
The West sees the rocket as a thinly-disguised way of carrying out U.N-banned tests of long-range missile technology, which it says not only threatens regional stability but is also a waste of resources when the country is struggling with a chronic food shortage.
There are concerns also that in upcoming weeks, Pyongyang will press ahead with a nuclear test, necessary in the march toward building a warhead small enough to be carried by a long-range missile.
At a somber memorial service Sunday, North Korea's top leadership eulogized Kim Jong Il and his son, who is certain to have gained national prestige and clout by going ahead with the rocket launch.
Kim Yong Nam, president of the Presidium of North Korea's parliament, credited Kim Jong Il with building Pyongyang's nuclear weapons program, and called the satellite launch a "shining victory" and an emblem of the promise that lies ahead with his son in power.
Top military official Choe Ryong Hae, meanwhile, warned that the army was prepared to defend the country's sovereignty.
Wednesday's launch was North Korea's second attempt in eight months to fulfill Kim Jong Il's 14-year quest to put a satellite into space. International experts confirmed that the rocket succeeding in reaching space.
Criticism of the launch was swift. The United States called it a covert test of missile technology, and U.N. Security Council condemned the launch as a violation of resolutions barring Pyongyang from developing its nuclear and missile programs.
However, the launch fit neatly into the preparations to mark the first anniversary of Kim's death and the rise of his young son.
Even before his death, Kim Jong Il had laid the ground for his son to inherit a government with national policies focused on science, technology and improving the economy. The son has been characterized as forward-thinking and tech-savvy - and the kind of man bold enough to take a gamble on a tricky rocket launch.
A launch in April, sent amid festivities to mark the centenary of the birth of North Korea founder Kim Il Sung, ended in failure shortly after liftoff.
Kim Jong Un made clear his intention to treat Wednesday's successful launch as a gift to his father.
He invited scientists in charge of the launch from a west coast launch pad to Pyongyang for the mourning rites, including a visit to the mausoleum where Kim Jong Il's body is believed to be lying in state "to report to him" on the success of the launch, according to state media.


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SW Florida weather: Mostly sunny, warm weather expected today
Southwest Florida should expect a warm day today with plenty of sunshine after the fog fades by mid to late morning.
Daytime highs will likely be a touch warmer today with temperatures peaking in the mid 80s except along the coast where the sea breeze will limit the temperature rise to around 80 degrees. Nighttime lows will reach the mid 60s.
A few spotty downpours may form over the interior east of I-75, but most of the area will end up staying dry again today.
Fog will continue to be a possibility for the next several mornings, reducing visibility to a half mile or less.
■ Super Groundhog Day: Handlers say Punxsutawney Phil predicts longer winter
■ CLICK HERE for the today's complete weather forecast from NBC-2
■ CLICK HERE for interactive weather radar and the week's local forecast
Subscribe to the Naples Daily News
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But it doesn't have to be.
Continue Shopping.
iHerb Customer Reviews
Tea Tree Eucalyptus Soap
1 person found the following review helpful
Posted by myreviews on Jul 09, 2013
This soap is brilliant.You don't need much of it to clean your scalp and hair well. It smells very fresh and I was surprised how good this product is. It makes your hair very manageable and nice. Will definitely buy the big bottle :)
Superb Eucalyptus scent!
1 person found the following review helpful
Posted by odereviews on Jun 26, 2013
What a nice soap. 100% natural! Superb eucalyptus scent. Good ingredients, and great travel size. I'd like to say that little goes a long way, but sadly that's not the case with this soap. Price was OK.
Love this soap.
Posted by Reviewer1717014 on Dec 11, 2014
It's mild, it works. The small size is convenient to take anywhere, and you can use it for almost any kind of cleaning. Great smell-- and I am very picky about scents and what I use on my body! It's got eucalyptus, but it's not as strong as some minty-products and leaves my skin really clean (no residue) and soft.
Great for travels
Posted by ekstravirgin on Oct 11, 2013
I keep this in my overnight bag - great for shower or a quick wash - I feel clean and refreshed
its a tinny flsck and ends fast
Posted by 5483161449576039062 on Oct 15, 2013
but the product is so good, and you feel like you are on a turkish sauna (because of the eucalyptus aroma)


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Passaic High School Alumni
Malena Polanco
Class of 2004
Israel Fernandez
Class of 1981
Hinda Stein Burstein
Class of 1976
Alana Darcel Reynolds-jones
Class of 1985
Even if alumni from Passaic High School have moved away from Passaic, New Jersey, they can use this site to find and contact high school friends. Don't forget to upload your Passaic High School pictures and check on the latest info about any Passaic High School reunion. While you are reminiscing about the times you spent in high school at Passaic High School, you should also check out alumni photos, yearbook listings and share any reunion info if possible.


text:
Delta State announces graduates
Delta State University awarded 418 degrees to students during Spring Commencement held Saturday, May 5, inside Walter Sillers Coliseum on the campus in Cleveland.
The degrees awarded include 293 baccalaureate, 99 masters, 13 educational specialists, and 1 Doctor of Education in Professional Studies.
Latest News
Manhunt ends with arrest A manhunt that started...
Cookin with The Columns: Bring home the bacon! These bacon rollups are...
Debate introduces District 3 supervisor candidates to voters race first up The candidate debate...
New business opens downtown Delta Mini Mall owner...
Aldermen set new water, sewer rates; hearing planned The Board of Aldermen...
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June 20, 2013
Jason Hursch supposedly a wicked fastball that he'll one day bring to the Braves' rotation.
Stories this photo appears in:
BRAVES NOTEBOOK: No. 1 pick Hursch signs; $5 ticket deal offered to rain-out fans
Jason Hursch, the 31st overall pick out of Oklahoma State, signs for $1.7M with the Braves this week and will begin his career in Single-A ball in Rome.
Use the comment form below to begin a discussion about this content.


text:
"Great talent, but too many management cooks in the kitchen. "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I worked at Falls Agency
Can take on as much as you'd like
Management cares about its employees.
Can wear many hats
Collaborative work environment
people are down to earth
Ownership is too hands on with the agency and the team. Never had the chance to have the reins taken off to let experts be experts. Not business savvy.
Ownership needs to let step out and let the staff competencies and talent shine. Needs to have a more diversified portfolio of clients. Needs to better embrace new technology.
- Any Location
- Any Job Title
I worked at Falls AgencyPros
excellent pay, casual atmosphere, fun tooCons
some bad employee choices tooDisapproves of CEO
"Like riding a bike in the sand. "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Culture & Values
- Career Opportunities
I worked at Falls Agency full-timePros
It's incredibly easy when you get the hang of it. The co-workers are mostly good people and the atmosphere is laid back when it can be. If you want a lax job and don't care where your life is going, this may be a viable place for you.Cons
No actual job descriptions. No raises. No bonuses. No opportunities for career growth. No leadership development or mentorship. No formal training. No seminars, lectures, workshops, outings... nothing.Advice to ManagementAdvice
Do everyone a favor and close your doors. After 30+ years of bumbling through running a business, it should finally be obvious to you that you are the cause of every major problem this business has. Honestly, you deserve some kind of a reward for being able to circle the drain this long, but rats have no merit. There's nothing to be proud of here.Doesn't RecommendNegative OutlookDisapproves of CEO


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The acquisition adds key product categories to support Toro's position in turf renovation.
The Toro Co. has acquired Louisville, Kent.–based Lawn Solutions Commercial Products, Inc., a manufacturer of turf renovation equipment for the landscape, rental, municipal and golf markets. The acquisition, which includes a lineup of aerators, seeders, power rakes and brush cutters, adds key product categories to Toro's portfolio to support growth across its core global businesses. Terms of the transaction were not disclosed.
"Turf renovation is a natural category for Toro having built our company around turf maintenance for almost 100 years," said Michael Drazan, vice president of the company's Contractor Business. "These products complement our brands and markets extremely well, while extending our offering to customers worldwide. With our expanded distribution and market strength, we believe we can deliver significant share growth in these categories."
As part of the purchase, David Cook, owner of Lawn Solutions, will continue to consult with Toro after the acquisition and provide important product development and category expertise.
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"I am very pleased with the style, colors, quality and turn-around time. I chose the modified rectangular envelope - the card fit inside really nicely and mailed without extra postage."
"Loved the invitation! Beautiful, better than I expected, colors & text were great and the weight of the paper was perfect! I would highly recommend this product!"
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All footage taken using a Canon 600D with a very old 18-55mm f/3.5-5.6 Lens Kit.
Original music written and recorded by Sissy Lowe.
Copyright 2013.
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