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Safety and Efficacy of Cerezyme® Infusions Every 4 Weeks Versus Every 2 Weeks in Type 1 Gaucher Disease
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This is a multicenter, randomized trial to compare the safety and efficacy of two dosing frequencies of Cerezyme® in patients with Gaucher disease who are currently being treated with Cerezyme®.
Approximately 90 patients will be randomized in a 2:1 (q4 : q2) ratio to one of two treatment arms at up to 26 study centers worldwide. Patients will continue to receive the same total 4-week dose that they were receiving prior to study enrollment, however, they will be randomized to receive either their total 4-week dose in two infusions, one infusion every 2 weeks or their total 4-week dose in one infusion every 4 weeks. The randomization scheme will ensure a 2:1 balance between the every 4-week versus every 2-week infusion groups, respectively.
Gaucher Disease, Type 1
Cerebroside Lipidosis Syndrome
Glucocerebrosidase Deficiency Disease
Glucosylceramide Beta-Glucosidase Deficiency Disease
Gaucher Disease, Non-Neuronopathic Form
Drug: Cerezyme
Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase IV, Multicenter, Randomized, Dose Frequency Study of the Safety and Efficacy of Cerezyme® Infusions Every Four Weeks Versus Every Two Weeks in the Maintenance Therapy of Patients With Type 1 Gaucher Disease
- Number of Participants With Clinical Success at Month 24/Discontinuation [ Time Frame: Month 24 (or at time of discontinuation) ] [ Designated as safety issue: No ]
- Mean Composite Scores of the SF-36 Health Survey at Baseline [ Time Frame: Baseline ] [ Designated as safety issue: No ]
- Mean Composite Scores of the SF-36 Health Survey at Month 24/Discontinuation. [ Time Frame: Month 24 (or at time of discontinuation) ] [ Designated as safety issue: No ]
- Mean Change From Baseline in Composite Scores of the SF-36 Health Survey at Month 24/Discontinuation [ Time Frame: Baseline and Month 24 (or at time of discontinuation) ] [ Designated as safety issue: No ]
|Study Start Date:
|December 2001
|Study Completion Date:
|February 2007
|Assigned Interventions
Q2 Cerezyme
Patients receiving Cerezyme one infusion every 2 weeks (Q2).
Drug: Cerezyme
Cerezyme doses of 20-60U/kg every 2 weeks (Q2 Arm) or 40-120 U/kg every 4 weeks (Q4 Arm).
Q4 Cerezyme
Patients receiving Cerezyme one infusion every 4 weeks (Q4).
Drug: Cerezyme
Cerezyme doses of 20-60U/kg every 2 weeks (Q2 Arm) or 40-120 U/kg every 4 weeks (Q4 Arm).
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- The patient must provide written informed consent prior to undergoing any study-related procedures.
- The patient has a confirmed diagnosis of Gaucher disease with a documented deficiency of glucocerebrosidase by enzyme assay
- The patient has been genotyped or will have genotyping performed within 3 months of study enrollment.
- The patient has been treated with Cerezyme for at least 2 years prior to study enrollment.
- The patient has been on a stable dose of between 20-60 U/kg every 2 weeks for at least 6 months prior to study enrollment.
- The patient is at least 18 years old.
- The patient has a hemoglobin value of ≥ 11.0 g/dL for women and ≥ 12.0 g/dL for men and a platelet count of ≥ 100,000 mm^3.
- The patient's liver volume is ≤ 1.8 x normal confirmed by MRI or CT within 6 months of randomization.
- The patient's spleen volume is ≤ 10 x normal confirmed by MRI or CT within 6 months of randomization.
- The patient has a serum creatinine < 2.0 mg/dL, an ASTand ALT < 2 x upper limit of normal and a total bilirubin < 2.0 x upper limit of normal.
- Female patients of childbearing potential must have a negative pregnancy test within 2 weeks prior to randomization into the study.
Exclusion Criteria:
- The patient is pregnant.
- The patient has evidence of neurologic or pulmonary involvement with Gaucher disease confirmed by medical history.
- The patient has evidence of current or prior bleeding varices or liver infarction requiring hospitalization confirmed by medical history.
- The patient has evidence of pathologic bone fractures, medullary infarctions, lytic lesions or avascular necrosis secondary to Gaucher disease confirmed by skeletal evaluation within 6 months of randomization.
- The patient has had a bone crisis (defined as pain with acute onset which requires immobilization of the affected area, narcotics for relief of pain and may be accompanied by periosteal elevation, increased white cell count, fever or debilitation of > 3 days) within 12 months of randomization.
- Patient has received an investigational drug within 30 days of the start of their participation in this trial. Patients may not receive any other investigational product throughout the course of the study.
- The patient has a clinically significant disease (with the exception of symptoms relating to Gaucher disease), including clinically significant cardiovascular, hepatic, immunologic, pulmonary, neurologic, or renal disease, or other medical condition, serious intercurrent illness, or extenuating circumstances that, in the opinion of the Investigator, would preclude participation in the trial or potentially decrease survival
- Patient has a medical, emotional, behavioral or psychological condition that in the judgment of the Investigator would interfere with the patient's compliance with the requirements of the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00364858
Show 26 Study Locations
|Study Director:
|Edward Kaye, M.D.
|Genzyme, a Sanofi Company
Additional Information:
No publications provided
|Responsible Party:
|Medical Monitor, Genzyme Coporation
|ClinicalTrials.gov Identifier:
|NCT00364858 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 15, 2006
|Results First Received:
|May 28, 2009
|Last Updated:
|September 3, 2009
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by Genzyme, a Sanofi Company:
Type 1 Gaucher Disease
Glucocerebrosidase Deficiency Disease
Additional relevant MeSH terms:
Deficiency Diseases
Gaucher Disease
Brain Diseases
Brain Diseases, Metabolic
Brain Diseases, Metabolic, Inborn
Central Nervous System Diseases
Genetic Diseases, Inborn
Lipid Metabolism Disorders
Lipid Metabolism, Inborn Errors
Lysosomal Storage Diseases
Lysosomal Storage Diseases, Nervous System
Metabolic Diseases
Metabolism, Inborn Errors
Nervous System Diseases
Nutrition Disorders
ClinicalTrials.gov processed this record on March 26, 2015


text:
The East L.A. Bookstore That Acts Like a Library Annex The East L.A. Bookstore That Acts Like a Library Annex
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subset: commoncrawl


text:
Hacking is an art and can be used for both offense and defense, for pro-active defense you need to know hacker tactics for securing yourself/organization against hacking, there exists a very thin line of hacker ethics distinguishing between a WhiteHat and a BlackHat hacker, I have always been very curious in learning this dark art for ethical purpose and finally got hold of "The Secret Of Hacking" - Ethical hacking course, unlike other outdated ebooks and basic courses this one is authored by an established Government recognized Indian security company and really packs a punch with all aspects of hacking and securing as promised on the sales page.
The course comes with one printed book and two DVD's having more then 14500 security related tools and 200+ Hacking E-books/Videos, the best part is that you get a lifetime membership with access to an ever growing collection of videos and technical support.
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Shop by...
Operating System
Form Factor
HP t410 Smart Zero Client (ENERGY STAR)(H2W23AT)
Zero management. Zero configuration. Zero compromise. Built with intuitive, auto-sensing technology for client virtualization environments that demand PC-like performance with simple deployment set-up and flexible protocol support.
Dual display connections
Featuring support for a native dual-digital monitor set-up through integrated DisplayPort and VGA connectors. Experience HD quality with single or dual display resolutions up to 1920x1200.
Impressive performance, innovative design
Maintain PC-like performance in a small footprint with a Texas Instruments TMS320DM8148 ARM® Cortex™ processor, 1 GB DDR3 SDRAM and 4 GB eMMC Flash memory capacity.
Featuring DSP Acceleration for RemoteFX, PCoIP and ARM® Neon extensions for Citrix HDX System on a Chip (SoC) for a powerful, flexible user experience.
HP Smart Zero Client technology
Automatic Intelligence, inherited by HP Smart Zero Client Services, establishes a secure desktop environment for all devices in minutes, and downloads everything it needs to deliver a robust user experience.
If your client virtualization software changes your HP Smart Client will adapt to your environment. Simply repurpose your HP Smart Client for another protocol, saving time and money.
HP Velocity
Reduce poor network connectivity in densely populated work environments with HP Velocity, a new HP feature. As network conditions change, HP Velocity reacts to maintain the highest quality performance.
Benefit from traditional, PC-like performance and multimedia playback while using less energy. ENERGY STAR® certified and EPEAT ® Gold registered. Low halogen materials and post-consumer recycled plastics greater than 10%.
Support beyond the box
The HP t410 Smart Zero Client includes a standard, three-year limited hardware warranty in most regions. Choose from HP Care Pack Services to extend service contracts. For more details visit http://www.hp.com/go/lookuptool.
|System features
|Standard memory:
|1 GB 400 MHz DDR3 SDRAM
|Browser supported:
|Mozilla Firefox 15
|Flash memory:
|Texas Instruments TMS320DM8148 ARM Cortex-A8 1 GHz
|See detailed specs:
|US QuickSpecs » pdf
|Operating system:
|HP Smart Zero Technology
|Communication features
|Citrix ICA
Citrix HDX
Microsoft RemoteFX (RFX)
Microsoft RDP
VMware Horizon View through RDP
VMware Horizon View through PCoIP
|Network interface:
|10/100/1000 Ethernet (RJ-45)
|Expansion features
|Supports up to 2 displays; 1 VGA, 1 DisplayPort 1.1a with resolutions up to 1920x1200 for single or dual displays. Actual performance and resolutions available will vary depending on client virtualization protocol being used and content being displayed.
1 microphone
1 headphone
1 power connector
|Power supply:
|24W worldwide auto-sensing, 100-240 VAC, 50-60 Hz
|Media devices
|Dimensions and weight
|Dimensions (w x d x h):
|7.28 x 5.83 x 1.28 in (14.8 x 18.5 x 3.2 cm)
|1.4 lb (0.638 kg)
|What's included
|Three-year limited hardware warranty
* HP is not liable for pricing errors. If you place an order for a product that was incorrectly priced, we will cancel your order and credit you for any charges. In the event that we inadvertently ship an order based on a pricing error, we will issue a revised invoice to you for the correct price and contact you to obtain your authorization for the additional charge, or assist you with return of the product. If the pricing error results in an overcharge to you, HP will credit your account for the amount overcharged.
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gypsylady wrote:, if you remember it. Enjoy.
Smileandhug wrote:Morning Gypsy, damn seen you ride by the other morning or was it that CCC playing up on me. CCC to those not a Queenslander is Canes Cutters Cordial (Bundy). I went out to Crows Nest for the show on FRiday. Was a nice day out there but a wee chilly at nite. But hey that CCC soon fixed that :#
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Thursday, January 14, 2010
Dee Perry welcomes back 17-year-old Grammy nominee Caroline Goulding for a live performance in the Key Bank studio, accompanied by From the Top's Christopher O'Riley. Plus, we look at how county reform might affect the arts in Cuyahoga County with Tom Schorgl of Community Partnership for Arts and Culture. And Marcie Bergman opens nominations for the 2010 Cleveland Arts Prize.
Arts and Culture, Government/Politics, Other, Courts/Crime - Fire/Law Enforcement, Music, Other
Please follow our community discussion rules when composing your comments.
Special thanks to the Oberlin Conservatory of Music at Oberlin College for the use of their Steinway Piano.
Production of arts and culture programming on ideastream is made possible by grants from:
By residents of Cuyahoga County through a public grant from Cuyahoga Arts & Culture.
The Cleveland Foundation; The Dominion Foundation; Eaton; The George Gund Foundation; The George W. Codrington Charitable Foundation; The Kulas Foundation; The John P. Murphy Foundation; Stroud Family Exempt Trust; The Robert O. and Annamae Orr Family Foundation; and The Nord Family Foundation.
The Ohio Arts Council helped fund this program with state tax dollars to encourage economic growth, educational excellence and cultural enrichment for all Ohioans.
Applause is an Emmy award-winning locally produced TV show that celebrates artists and cultural groups around Cleveland and Northeast Ohio.
The Sound of Applause, ideastream's weekday radio magazine, celebrates the visual and performing arts, explores cultural trends, and examines current events through an artistic lens.
Show ideas & comments? Let us know.
Thursday 7:30 PM
Friday 11:00 PM
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Monday 12:30 AM / 4:30 AM / 8:30 PM
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Dee Perry image courtesy Chris Stephens, The Plain Dealer


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Soda as Bad for Your Teeth as Meth
(NEWSER) – A severe soda addiction can be as terrible for your teeth as a meth or crack habit, according to a case study in General Dentistry spotted by NPR. Study author Mohamed Bassiouny says he noticed the frightening similarities during his 20 years treating dental patients at Philadelphia and Appalachia clinics. His paper's scope is much more limited: It focuses on just three patients displaying extreme dental erosion in the form of teeth lesions with "almost identical features": a 3-year meth user, an 18-year coke user, and a woman with a 3-year diet soda habit of 2 liters a day.


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The dominance of Windows
simplification of the GPL and official translations of the GPL in different languages. (that's from someone who develops commercial/closed source software...and I really can confirm that one of the major reasons people develop closed-source software is, that the code is ugly. Also sorry but I've to make a living, same for my bosses and my colleagues)
Last edited by Detructor; 06-10-2012 at 01:07 PM.
The dominance of Windows
- Bad power consumption - most people have laptops. This should be a priority.
- Audio In - why doesn't it work reliably? People use microphones for chatting over the internet. The fact it doesnt work is bad.
- Stable interfaces/api/etc so that if a core component is updated to a newer version, things that depend on it won't break or become glitchy.
- Stable method for video drivers (binary or otherwise) to hook up with the kernel/video system. So that we can use binary drivers with newer kernels, etc. even if the driver hasn't been updated (or support for it has been dropped)
- 64bit OS should be able to run 32bit binaries.
- The ability to update individual programs to their latest versions. Why do they always have to be compiled for your specific os?
- HP - why do I have to go to their website, download and run their program to get all the binary bits to make the printer work properly. Why isn't this automated?
Mark Shuttleworth is a good example of what can happen, but lately he's going over the edge and belittling his position by jumping into supporting Microsoft's Azure. Why would you want Windows users to never need to drop and move to Linux by giving them all the goodies of Linux. Crazy.
The Stars of Linux/GNU;
Mark Shuttleworth
Linus Torvalds
Richard Stallman
Up and Coming;
Aaron Seigo
Jono Bacon
Michael Larabel
Various Podcasters
Star Projects:
Another GRIPE:
Lack of GUI to visualise sound channels, be that mainly for recording recording
And btw, it's not Canonical who supports Microsoft, is Microsoft's service that supports Canonical's operating system.
In my opinion: everything boils down to these two things:
- Lack of commercial support. Like it or not, distros run on hardware that needs to be supported by drivers, and powerful software can only be written with financial backing. Companies at the moment don't seem willing to support Linux as much as they do for Windows and Mac.
- Lack of standardization: This is both a good thing and a bad thing. While you pretty much get "freedom of choice" (i.e. you can run KDE on a Wayland server running on an ARM machine, or you can run GNOME on an Xorg server running on an x86 machine), this makes the job much harder for people who need to get their software compatible across all configurations.
I'm against cloud computer btw, unless it's personal cloud run from your own home or business. I have no interest in storing personal files with Microsoft, or Amazon. I don't want to buy an mp3 and have MS store it. It's easier to have a storage device, like USB memory dongle or Secure Digital card. If we continue to not use cloud, Buyers promote personal technologies.
Here are the main flaws I see with Linux:
1) Lack of consistency. There are WAY too many internal changes between every update for most distros. To be honest, I don't care if I'm using XOrg 7.4 or 7.7 I don't notice any difference, and I have to ask, what really IS the difference? Remember back when distros kept switching between HAL and XOrg for input? That was a huge mess. Distros would flip between the two every release, and it was really confusing. Things like that make it really difficult to even target a single Linux distribution. Let's say I want to release something for Ubuntu. What can I assume about the system? Very little.
2) Publicity. Why don't I see commercials for Linux when watching TV or even ads for the system when browsing the internet? It's not that there isn't a market, it's that there isn't awareness. I go to a super techy (well known/prestigious) engineering school and you'd think that everyone there would have at least heard of Linux. Nope, maybe a third of the kids I know had not heard of it till I mentioned it. How many kids actually use it as their main system? Not as many as you'd think considering the comp sci department recommends using Linux very strongly and a lot of the labs we have (including the robotics lab I do research in) use Linux exclusively.
3) Too little of a focus on end users. Most Linux projects are focused too much on internal technicalities that very few end users care about! Rather than trying to create a system with features that will make users happy, they care too much about things that only very niche users will want.
4) End user documentation. Why isn't there a super easy place that I can go to that I know will have the answers to all my Linux questions? Everything is scattered about and half the questions I have I don't even end up finding an answer for even if I post on well known Linux forums. Further, there is very little that Linux distributions try to do to ease the transition to Linux. Sure, the changes in applications (like renaming applications to things like Web or Files) and such that ease the transition are nice, but I'm talking about a "welcome to the Linux world, here is how the mentality is unique" type of thing. Most people I introduce Linux to try to install applications by going to websites. What's up with that?
5) Developer documentation. Too many open source applications out there have a steep learning curve to help develop them. Not enough projects have a "here is what you can do to help" initiative.
6) Friendliness of the community. While a lot of Linux users are eager to help, there tends to be a harsh bitterness and lack of understanding toward newbies. Sure, a lot of us hate Windows, but is that the best way to introduce ourselves? We really suffer from some huge ego problems. Also, some users have legitimate reasons that they have Windows or Mac OS X on their systems at all. Why bash them for it? What Linux has and always will be about is personal choice.
7) File structure. Why do we have /bin, /usr/bin, /usr/local/bin, and perhaps a ~/bin if you feel like it? Sure, I know why but new users shouldn't have to learn. It should be clearer than that. Besides, could someone explain to me what exactly /var is supposed to be used for? I feel like that's pretty unclear and everyone has a different interpretation of it. /local vs /opt? Huh?
8) I want some better terminal emulators :P I feel like there could be some modernization in some aspects, but perhaps that's just me. (More interactivity? ie. right click on a command and open up a separate documentation window, or maybe right click and upload to pastebin, or easy Googling functionality or something. Why aren't these things super common?)


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How to transfer Gems on game clash of clans ? - Clash of Clans Questions for iPhone/iPad
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EU blocks Ryanair bid to take over Aer Lingus - Comments
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Why does Vasquez look like Sokka from Avatar?
Now I do voice overs. Finally!
Click here for my first voice demo!
My Anthony Davis website: http://thebrow.uphero.com/
Vasquez loves the TO
Darius Miller should be our starting SF
Look at what Davis is doing already. People are so worried about Davis getting going they leave Anderson alone for a moment. And BANG.
Gotta fight through every screen vs Ray Ray, Austin. Every time.
I wanna see an iso, Davis vs LeBron.
vasquez is gonna lose a lot of games for us if he doesn't cut down on the turnovers.
Rivers is starting 10/31. My prediction will be true. Book it. Vasquez no way no how.
Damn General G. and all those TO's. It's really gotten out of hand. He can't just waste possession like that.
Vasquez is too slow for this league, I hate to keep being negative about him but he's just not starter quality. On that fast break Ant wanted the lob but he sort of out ran Vasquez himself, then when Vasquez tried to move after Ant screened, he was too slow and got the ball stolen from a quicker player.
It's shocking to me how much worse Vasquez has been this preseason.
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Saline County Quorum Court voted late Tuesday to levy an annual voluntary $5 tax on every tax statement for real property in the county for the purpose of financing animal control services in the county.
Ten justices of the peace supported the ordinance that drew harsh criticism from Mark Kizer, who represents District 3 on the court. Also voting against the ordinance were Dr. Allan Dabbs of District 5; and Mike Creekmore of District 11.
Kizer chastised the court for approving an ordinance that he says puts responsibility on the sheriff's office that does not have adequate manpower to provide the service.
"They don't have time to do this and the money's not there now, and we don't know what money will come from this," he said.
"I'm not for it and I think it stinks," Kizer said.
Deputy David Blevins, the county's environmental officer, is expected to be assigned this task. When Sheriff Bruce Pennington was asked whether Blevins will have time to serve in this capacity, he replied, "Not really."
Kizer replied, "Y'all just passed an ordinance and he doesn't have manpower to do it."
Pennington then added, "When he's not busy, he would have time."
Kizer told Pennington to "get ready to get the phone calls now."
Later in the meeting, James Mashburn, a resident of the East End community, said he supports the animal tax "if we can pass a leash law in the county."
Mashburn cited incidents in which free-roaming dogs have killed his animals and attacked horses said he has "declared war on dogs."
"Dogs running loose is a major problem out there (in East End)," he added.
Voting for the measure were the following nine JPs who sponsored the ordinance: Josh Curtis, District 7; Tammy Schmidt, District 6; James Zahnd, District 13; Josh Mesker, District 2; J.R. Walters, District 12; Jim Whitley, District 10; Barbara Howell, District 4; Greg Thomas, District 9; and Pat Bisbee, District 1.
In another matter, the court unanimously voted for an ordinance approving the issuance of $8 million in bonds to make physical improvements at Saline Memorial Hospital.
Carla Robertson, chief financial officer for the hospital, reviewed projects that are planned with the additional revenue. Included will be renovation to the facility's MRI unit and CT units; improvements to the facility's emergency power system; adding additional patient rooms; and roof renovations.
"We're doing a lot of rearranging," Robertson said. "We're creating additional patient rooms where the old emergency department was."
No county funds will be used in any of the projects, but the county owns the hospital, which is leased to Saline County Medical Center, a not-for-profit corporation. Arrangements are being made for Stephens Inc. to serve as underwriter for the bond agreement, the ordinance notes.
In other matters, Don Birdsong, administrator of the Saline County Detention Center, presented a review of the jail for 2012. Birdsong was positive in his evaluation of the facility.
"We have more major felons in our jail than we've had in a long time — we're housing a lot of murderers — but they're where they belong, and we're doing well," he said.
Medical care at the facility has been improved with additional staffing, Birdsong added.
"We have an EMT on staff and have a doctor on call now 24-7. We have two nurses on staff for five days a week."
Expenses are kept to a minimum, he said, through charging inmates at a rate of $3 a meal "to try to recoup as much as we can" from the cost of housing prisoners.
"We have a new gated system, with fencing all around now," he said. "We feel like we can prevent any escape from happening. We've bought new mattresses, and we have passed all evaluations with flying colors."
"We're staying within the budget, being good stewards of the county's money," he added.
Birdsong said a new contract has been signed this week with the Arkansas Department of Correction for housing prisoners.
"We don't anticipate any problems in 2013 and we look forward to working with you," he said.
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Senior Member
Hokay, as I write this the date is 12/31/09 and the current patch is version 126.96.36.199. This is a guide to Tristana, one of my more recently acquired tastes and a bundle of guntoting, flying laughs. Tristana is one of the better ranged physical heroes in this game, topping Ashe and Teemo easily on my list, her sheer damage output and brilliant escape mechanisms made up my mind rather quickly. So, if you like making ****ing donuts out of people's chests and turrets this is the hero for you. (Note: Yelling "BOOM HEADSHOT!" after Buster Shot kills is incredibly satisfying, especially when the Ashe playing next to you almost knocks his chair over because of it, LoL.)
If you're up for some more reading and have an interest in improving as a player overall I recommend reading this thread written by condon.
Before You Start Plugging People... (The Pregame)
A. Spells
I recommend teleport on Tristana as almost a requirement, her ability to annihilate buildings is highly augmented by quick entrances to lanes the opponent was otherwise ignoring. It also increases your map control and ganking potential which is key for any hero. If you plan to solo, I can't stress getting teleport enough, leaving your lane alone with an enemy solo for any long amount of time can be disastrous as they will *****slap wave after wave of creep and possibly **** up your turret first, and we can't have that.
Second spell, I personally take Exhaust as it gives you more time to blast some dumbass Goomba you jumped on and also has carry control and escape uses, get creative. It won't do anything if you leave it on cooldown waiting for that perfect moment so use it often.
Other options include Ignite and Flash for personal play. Flash is amusing for the surprise of blowing people away from their turrets and team with Buster Shot and then jumping back on them and Ignite gives you a significant DoT component to any gank.
In a premade setting Rally, Clairvoyance etc can be used, but I wouldn't bother unless you're planning to play with a predetermined team.
B. Masteries 21/0/9
Offense Utility
3/3 Malice 1/1 Cripple 1/1 Spatial Accuracy 3/3 Perseverance
4/4 Sorcery 4/4 Alacrity 4/4 Awareness
1/1 Archaic Knowledge 1/3 Sunder 1/1 Greed
3/3 Brute Force
3/3 Lethality
1/1 Havoc
This is my personal build, play to your strengths when doing Masteries, everyone likes different things and the 'standard' build doesn't always fit you. I like to pick up Archaic Knowledge instead of more Sunder or Offensive Mastery or Archmage's Savvy for the MagicPen, this will magnify the terror you unleash with Rocket Jump, Explosive Shot, and Skull**** (aka Buster Shot).
C. Runes
I'm not going to get too in-depth here, as I haven't number crunched efficiency of the different types of runes, but if you're using my item build crit chance and crit damage are preferable for Red and Yellow slots, though I hear ArPen runes are the best for Red slots. Mana Regen per Level or CDR are a decent choice for your blues. Quints are your call.
The Skills That Pay the Kills
A. Skill Progression
First off, I definitely recommend taking the solo lane. Your ult does as much as the MFing Cho'gath's at level 6 and you can use yours to bat people around like Babe Ruth or just to splatter their brains all over the ground from afar. Still, if some jackass insists on soloing or you just don't feel like it, you'll do fine in a lane.
You'll prefer a partner that doesn't need a lot of gold, aka not Yi, Pirate, etc. In my experience Blitz, Singed, Alastair are all fantastic lane-mates for getting easy kills, but pretty much anyone with a slow or stun will do the trick.
B. Skills
Rapid Fire (Q)
Tristana fires her weapon rapidly, increasing Tristana's attack speed by 30 / 45 / 60 / 75 / 90% for 7 seconds.
Cooldown: 20 seconds
Cost: 100 Mana
Pretty self-explanatory skill, Rapid Fire is your bread and butter skill when killing powerful neutrals (rune monsters, dragon, Baron), in a hero battle, or when pushing turrets. Don't use it any other time as the mana cost can be prohibitive on a low mana character like Tristana and Rocket Jump is more effective at clearing a creep wave.
Rocket Jump (W)
Tristana fires at the ground to propel herself to target location, dealing 70 / 115 / 160 / 205 / 250 (+0.8 per ability power) magic damage and slowing surrounding units by 60% for 2.5 seconds when she lands. On kill or assist, Rocket Jump's cooldown resets.
Cooldown: 12 seconds
Cost: 100 Mana
Range: 900
Jump is Tristana's best skill early game by far, nothing makes half-health heroes shat their pants more than an angry Smurf with a huge gun dropping on their face, learn to love it. It also serves the dual purpose of allowing a scared ******bag (that's you, yes I'm looking at you Timmy) to fly to safety over a wall or just generally away from the direction of the oncoming death.
The uses of jump are limited only by your creativity and mana, remember it comes off cooldown every time an enemy champion you participated in killing dies. This allows for some interesting tricks if you have the mana to spare and the creativity to think of them on the fly. If you killed someone on a turret dive don't forget that you can jump right back out after.
Explosive Shot (E)
Passive: While Explosive Shot is ready to cast, enemies explode when slain by Tristana's attacks, dealing 30 / 50 / 70 / 90 / 110 magic damage to nearby enemies.
Active: Explosive Shot rends target enemy, reducing healing and health regeneration by 50% and dealing 25 (+0.1 per ability power) Magic Damage per second.
Lasts 4 / 5 / 6 / 7 / 8 seconds.
Cooldown: 16 seconds
Cost: 50 / 60 / 70 / 80 / 90 Mana
Range: 600
Explosive Shot allows you to clear your lane at a decent clip, you may miss out on some last hits because of it but the free pushing power is worth the trade off.
It also has a nasty active that will apply a healing reducing DoT effect to the enemy, this is your best friend against Mundo, Singed, etc that have high healing moves. As soon as you see their ult go up slap them with an Explosive Shot to deny them much needed regeneration, you can also deny half a heal spell if you can anticipate your opponents accurately.
The debuff is the most useful portion, but don't discount the DoT if you think a low-health opponent will get away, especially if you're packing Ignite as well. I like two ranks of this early for decent explosions and 5 seconds of healing prevention for ganking.
Buster Shot (R)
Tristana fires a massive cannonball at an enemy unit. This deals 300 / 400 / 500 (+1.5 per ability power) magic damage and knocks surrounding units back 600 / 800 / 1,000 distance.
Cooldown: 60 seconds
Cost: 150 Mana
Range: 700
Tristana's ultimate does exactly what you would think. It shoots a god-**** HUGE bullet straight at some MFer's forehead. The shot is so strong it sends them and surrounding units heads over heels in the other direction. Buster Shot is fantastic, it's one of the strongest level 6 nukes and the knockback component has many different uses. The AP ratio is obnoxiously high (see Ambi's guide on AP Tristana for more on that) and it just ****s people up, no questions asked. I find the best use of the spell to be a finisher, given a non-lethal shot blasts them directly away from you and in all likelihood to safety, but don't be too conservative with it as it can serve many functions.
With practice, the knockback is an easy way to split people from their teammates, push them into turrets, knock away a chaser, push them into your team, and on and on. Like jump Buster Shot has a fantastic number of uses that with practice you can master. I've used Buster Shot to push entire TEAMS away from a fleeing teammate, for example. Bunches of people make for great targets and you could find a worse initiator than Buster shot, provided you know what you're doing. It also functions as an interrupt effect, Nunu isn't so scary if every Absolute Zero is immediately countered by a Buster Shot. Same thing with Fiddle, blast his happy ass and his Crowstorm far away from you and your team.
Which Cannon Should I Pack?
Like any physical carry, Tristana focuses on Damage, Crit %, Critical Damage, Attack Speed, Life Steal, and ArPen. Obviously each is good, but how do you decide which is best? By looking at those fools on the other side of course.
After further testing with different builds I've stumbled upon a new one which I find I like more and more as my games go on. Looks like this...
Starting Items: Brawler's Gloves + HP Potionx2
First Trip: Pick up your Boots of Speed and work towards finishing your Zeal, if necessary buy another health pot or two if you're really taking a pounding in your lane.
Second Trip: Finish your Zeal and upgrade your boots. If you see really clear threats pick up either the Merc Treads or Ninja Tabi, if it's spread around enough or you're feeling crazy feel free to get Zerker's Greaves.
Third-Fourth Trip: Vampiric Scepter and a BF Sword, you're looking to finish a Bloodthirster sometime in the near future.
Xth Trip: Finish up your Phantom Dancer now, as fast as you can. I recommend saving for the Crit Cloak as your next item as you should have plenty of IAS.
After this head for an Infinity Edge at your best judgment, I usually buy the damage items before the crit cloak and mix in a Green Elixir after a purchase if I can. Trust me this Elixir pays for itself every time. By the time you finish your Infinity Edge, you will be able to bust a cap in even the toughest characters' asses.
After this you can do whatever needs to be done. High armor heroes? Last Whisper or Black Cleaver. Need more lifesteal? Another Bloodthirster or Stark's if your team doesn't have one already. Getting dodged too much by that ****rat Jax or Nidalee? Try Sword of the Divine (extreme cases only). Want some more HP or tired of *****es running away? Frozen Mallet works well, though normally all you would need is Phage with the IAS you get. A Banshee's Veil can help you against being stunned and focused or being grabbed by a Blitzcrank. I've had success building all of these items, you really need to examine the enemy composition, figure out where the problem is or will be and build to counter it. If your dominating and can't think of anything specific, more elixirs can wrap a game up before they can catch up to you. If you have an early game advantage in kills and towers, DON'T WASTE IT! If you can cap the *****es in mid-game do it, don't give them the chance to don their Kevlar for end-game.
As a side note to that, if you have a big creep wave and you just pushed an inhibitor, you don't have to back right away if the enemy isn't a threat right away. Don't forgot you're Tristana, the tower killing Smurf and those base turrets are just as delicious as the ones outside their other inhibitors and you can hop the base wall for a quick getaway. This is more of a common play-tip then something Tristana specific, but I've known I've come back to win games that an opponent could've ended if he'd gone for the base instead of lanes, don't make this mistake.
Ready, Aim, FIRE!
This focuses more on the solo lane in early game than the dual-lane, I can't give you one or two strategies that will work for every two-hero combination you face with lanemate X. Just remember coordination is the key to a two-person lanes and good use of Rocket Jump will net kills or at least force them to hug their turret for dear life.
Early Game
Get to your lane, preferably middle. If you're in top or bot you can set-up the gank in the bushes if you want, if you have exhaust you can get a kill between it and jump if they just walk into you.
In middle just be prepared to get some good last hits, you don't need an early kill, I prefer to gauge my opponents reactions to different things during this phase. If they don't mind being shot try to get them to half or two-thirds HP, that's gankable at level 3. If you find yourself against an aggressive opponent stay near the back, make sure if they come to hit you you have a few ranged creep around to punish them for it, give them a couple shots in the ass yourself as well. You're looking for a lull in a creep-wave where you can jump in, chain slow with exhaust or dot with ignite, and pick up a quick kill.
If they play it conservatively push them up against their tower, focus on clearing the creep rather than attacking them. Rack up some damage on their turret, they'll have a hard time last hitting already if the tower is shooting your minions. If they attack you they get even less gold and if they don't you're going to get their turret down very quickly, win-win for you.
The most important part of not being killed in middle is map awareness, keep an eye on the map. Stress MIA calls from your teammates, but if something goes wrong you may find an enemy at your back if you aren't paying attention. Plan your escapes ahead, you can exhaust the person behind you and just run past if their DPS or you can head either way in the river to make a quick wall-jump to evade pursuit. (Baron or Dragon work especially well for this.)
This phase of the game will end for you when you kill their first turret generally, if you're having trouble call for an assist, two heroes and a creep wave can down a turret easily once you kill the solo or if they were the conservative type you should already have enough damage on it to finish it off on your own.
The first middle turret should be dead and that leaves you free to go to other lanes and have a ball. You should be able to pick up some Golem and/or Lizard buffs without much effort to remain in the field longer. Your goal here will be to gank lanes or push turrets. Good jumping with a Buster Shot will easily net you a kill with the two lanemates already in bot or top. One hero won't be able to generally stop you 3 from pushing a turret so take the first turret in all the lanes down as quickly as possible.
I'd also recommend killing dragon when you have a chance, he's soloable once you have a damage item, but he can be two-manned easily at any point past level 6. All of these things will be leading to an early gold advantage for your team that you can turn into a potent battering ram for pushing to inhibitors.
If your team ties up 3-5 of the opponents in a battle over one of your first turrets feel free to push another lane to the second turret with a quick teleport, this is an effective strategy because without multiple disables or 3+ heroes to burst you down you can escape most gank attempts.
End Game
Endgame focuses around team pushes, team battles, inhibitor kills and Baron Nashor. At this point your opponents are rarely, if ever, alone and you shouldn't be either. Keep the lanes pushed, but be wary of missing heroes as they are likely group-hunting for kills.
Your now probably putting out huge amounts of damage, but with a small health bar. You want to stay back from the action now. Keep near the back or middle of your team, save Buster Shot for kills or saving teammates, and make sure to focus their carries first. Jump becomes an effective AOE slow for fleeing enemies and make sure to Explosive Shot characters that plan to use regeneration or healing to outmatch your DPS.
Worst-case scenario you have amazing backdoor power, enough to take down Inhibitors and perhaps turrets with ease. Never discount backdooring an enemy Inhibitor, it's a risky play but sometimes worth it in a bad situation.
Play smart and you'll come out of end-game on top. Terrible choices lose people games at this stage and going to get that Golem all by yourself when they're missing can cost you a lot. The respawn times are anywhere from 50-70 something seconds and dying for something minor is NOT worth the risk.
Once they're on the defensive you can get Nashor or just go win, but don't be the guy with Baron buff that runs in and gets his ******* torn open. It's a buff, you're not the Almighty and you'll explode just as quickly with it as you do without it from good focus. Let your tanks and disablers do their job and then demolish the threats with your range.
In short, you do what you've been doing. The only difference is they've decided to group up and just give you all the kills at once to save you time and bullets.
Credits/Closing Remarks
Thanks to condon for writing good guides to Gangplank and Cho'gath, they sort of inspired me to do this. Thanks to Ambi for writing the AP Tristana guide, that got me interested in playing this character, even though I prefer an attack build now, the AP build is fantastically fun as well. Also credit to Ambi for the skill tooltips I used in Skills part B.
Hope you enjoyed reading this guide, if you have read this far you owe me 100 bad solo Ashe scalps, they're a dime a dozen right now with Ashe on free-play.
I'm always looking for feedback, I look forward to hearing yours and hope you have success and fun with Tristana.
P.S.: Happy New Years!
Beegly Boogs
You get the same item order and spell order as me. Creepy.
no offense but you're not very good at condon's writing style. >.<
I think there's too much emphasis on attack speed. Rapid Fire gives enough attack speed that you don't need to focus so much on it.
I also prefer getting E up as my main priority constantly, since the farming benefits are huge.
My preferred build is;
Vamp. Sceptre
BF Sword
BF Sword
Black Cleaver
Phantom Dancer
Starks or Malady.
After Zeal the order is really fluid, though, I just play for whatever I can get.
Possibly get infinity edge at some point but games rarely last that long.
Berserkers shouldn't be set in stone IMO.
I'd much rather have 11% dodge against a physical heavy team, or 40% CC reduction against a magic heavy team.
But maybe that's just me?
I main tristana and agree with most of the play style recommendations, but take issue with your skill and item builds.
I HIGHLY recommend prioritizing E (explosive shot) then Q, leaving your rocket jump for last (minus the 1 point at lvl 1 for jump-ins/escaping). You get the same jump distance and slow from rocket jump, regardless of level, and the damage increase is negligible unless you are going for an AP build (which I feel is weaker than pure DPS). I'd much rather have a high level explosive shot to aid in farming, and keeping my opponent back a little ways, plus it pairs nicely with ignite.
Runes: There are a bunch of relatively low cost crit chance items, so I decided to go pure crit dmg which helps me carry late game.
I modify my builds depending on their lineups but here is my general build:
Starting: Doran Shield or Blade + Pot - If I expect to lane vs a good harasser or heroes with a lot of poison (twitch/teemo), I'll get the shield, otherwise I'll get the blade. I don't care if people think doran blade sucks, I like the +hp and the +6 dmg it give early on for some reason makes it significantly easier for me to last hit early game.
Vamp Scepter is weak (near useless) without + dmg, and if you go straight to malady or bloodthirster you will be weak in dmg output early-mid game.
Trip 1: Usually 2x Long swords, + boots
Trip 2: Finish up Brutalizer, Beserkers Greaves (sometimes merc treads), buy Vamp Scepter (sometimes I can do some of this in trip 1 depending how well the game is going)
Next: BF Sword
Next: Bloodthirster or Infinity depending on much money I have. Ideally I want to get Infinity for the crit chance, but if my team is struggling mid game I'll get bloodthirster for the cheap dmg output.
Next: zeal --> phantom or Phange. If I got Infinity I'll generally get phange for the slow and health. If I got bloodthirster I'll get zeal for the crit chance
In general my builds end up looking like one of these two depending on if I get bloodthirster or Infinity as my first high tier item.
Beserker Greaves
Phange (finish into mallet later)
Bloodthirster (getting vamp scepter mid game)
-replace doran with black cleaver or madreds bloodrazer last
Beserker Greaves
Phantom Dancer
-replace doran with black cleaver or mallet last
Weak in damage with bloodthirster? I'm sorry, bloodthirster gives up to +100 damage.
I prefer going for Executionner's Calling, then Boots of Swiftness, then Black Cleaver and then Zeal.
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Tracey Worzella, Andrew Niles and Michael Busch*Promega Corporation, Madison, WI 53711 and *CyBio AG, Goeschwitzer Strasse 40, 07745, Jena, Germany
We demonstrate the use of automation to perform high-throughput and ultra high-throughput cell-based multiplexing studies. We provide protocols and supporting data that demonstrate the automation synergies of the assays and CyBio CyBi®-Well hardware described here. The Promega MultiTox-Fluor™ and MultiTox-Glo™ are novel non-lytic reagents that have been developed to distinguish between viable and non-viable populations of cells in the same well. The ratio of live and dead cells can be used to normalize data in order to reduce error associated with cell dispensing or clumping. Using independent cell viability and toxicity readouts within the same well serves as an internal control and helps identify errors from interferences due to test compounds or medium components.
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Parmatown serves as poster child for commercial mortgage risk
Blog Entry:
January 16, 2013 1:19 PM | Author: SCOTT SUTTELL
Some investors are steering clear of mortgage-backed securities tied to retail real estate,
The Wall Street Journal
, in a story that includes as one of its case studies the sale last fall of Parmatown Mall.
The paper says that "commercial mortgage bonds, including these shaky malls, have lagged behind a recent rally and retail loans in new deals are getting greater scrutiny from investors and rating firms."
Overall, default rates on mortgage securities backed by shopping malls, shopping centers and other retail properties "are lower than on most other commercial-real-estate categories — 7.7% of the $172.5 billion in retail loans outstanding in bonds are delinquent," according to
The Journal
. "But when individual retail properties get into trouble, their values plummet faster than other property types, which can result in greater losses for investors."
The newspaper notes that one example of mortgage investors' pain came with the sale last November of Parmatown. "Holders of the mall's $61.6 million securitized mortgage received proceeds of $5.9 million from the sale, 90% less than they were owed,"
The Journal
The paper says Parmatown, opened in 1962, had struggled since SouthPark Mall opened 10 miles away in Strongsville in the 1990s. Parmatown's previous owners, founders of Forest City Enterprises Inc. operating as RMS Investment Corp., had redeveloped the mall and added a Walmart in an anchor location long abandoned by Dillard's.
"Based on an appraisal in 2004, just before the commercial-mortgage-bond market began its explosive growth, Parmatown was valued at $111.50 a square foot,"
The Journal
reports. "That was reduced to $17 a square foot at last year's sale to Cincinnati-based mall owner Phillips Edison & Co."
Follow the money
A good
investigative piece
on PublicIntegrity.org finds that the Supreme Court's
Citizens United decision "unleashed nearly $1 billion in new political spending in the 2012 election, with media outlets and a small number of political consulting firms raking in the bulk of the proceeds."
Federal Election Commission data show that throughout the 2012 election, "corporations, unions and individuals that could take advantage of the high court's ruling were responsible for about $933 million of the estimated $6 billion spent during the contest," according to the story. Nearly two-thirds of the new money — about $611 million — went to 10 political consulting firms, according to a Center for Public Integrity analysis.
All but one of the top 10 recipients "bought advertising in various media markets on behalf of super PACs and nonprofits," the story notes. "Eighty-nine percent of the expenditures made to the top 10 went to spots attacking candidates, the data show."
The story then details the murky world of campaign finance.
One of the top 10 recipients was American Media & Advocacy Group, a favorite of conservative groups, which ranked No. 5 at $27 million.
In Ohio, the story notes, American Media & Advocacy Group was paid by the conservative Congressional Leadership Fund "to purchase ads slamming Democrat Betty Sutton in the House race for District 16." American Media was also working for the Rep. Sutton's Republican opponent, Rep. Jim Renacci.
"The same person was listed in records as buying media in the Cleveland market — at the same TV station in at least one case — for both the Renacci campaign and the Congressional Leadership Fund," according to the story.
This and that
A matter of antitrust:
that Cleveland law firm
Squire Sanders
is beefing up its antitrust practice with the addition of Mark Botti, antitrust head of Washington, D.C.-based
Akin Gump Strauss Hauer & Feld LLP
, and two colleagues, J. Brady Dugan and Anthony Swisher.
Mr. Botti, head of Akin Gump's antitrust and unfair competition practice, previously spent 13 years at the U.S. Justice Department, Bloomberg notes. There, he was the assistant chief of the Antitrust Division and oversaw hearings by the Federal Trade Commission on health care during 2004 and 2005.
"The expansion of our antitrust practice has been one of the key strategic goals of our Washington, D.C., office and our regulatory practice," said Jim Maiwurm, chairman and global CEO of Squire Sanders, in a statement. "As antitrust scrutiny and enforcement continue to rise around the world, the addition of this team to the firm's existing global antitrust and regulatory capabilities will enhance our ability to support clients in this strategically critical area."
Mr. Botti represents clients on antitrust matters that include government investigations, mergers and acquisitions, and joint ventures.
Drinking problem:
Need more evidence you should stay away from consumer energy drinks? Check out
this Associated Press story
, which includes a comment from a suburban Cleveland doctor.
"From 2007 to 2011, the government estimates the number of emergency room visits involving the neon-labeled (energy) beverages shot up from about 10,000 to more than 20,000," the AP reports. "Most of those cases involved teens or young adults, according to a survey of the nation's hospitals released late last week by the Substance Abuse and Mental Health Services Administration."
More than half of the patients considered in the survey who wound up in the emergency room told doctors they had downed only energy drinks," according to the AP. In 2011, about 42% of the cases involved energy drinks in combination with alcohol or drugs, such as the stimulants Adderall or Ritalin.
"A lot of people don't realize the strength of these things. I had someone come in recently who had drunk three energy drinks in an hour, which is the equivalent of 15 cups of coffee," Dr. Howard Mell, an emergency physician in the Cleveland area who serves as a spokesman for the
American College of Emergency Physicians
, tells the AP.
"Essentially he gave himself a stress test and thankfully he passed," he says. "But if he had a weak heart or suffered from coronary disease and didn't know it, this could have precipitated very bad things."
Music to his ears:
Real estate developer Bruce C. Ratner of Forest City is
spreading his wings
Mr. Ratner, who leads
Forest City Ratner Cos.
in New York City, built the Barclays Center in Brooklyn that already has hosted concerts by Bob Dylan, Barbara Streisand and the Rolling Stones, among others. But, as
The New York Times
notes, "when the genre chosen was Jewish music, (Mr.) Ratner decided to take charge himself."
The developer, whom the paper says "cut his musical teeth on cantorial singing at a synagogue in his hometown, Cleveland," is the de facto impresario of a concert at the Barclays Center announced this week that will feature the violinist Itzhak Perlman and Yitzchak Meir Helfgot, the cantor from the Park East Synagogue in Manhattan who has been a leader in the revival of Jewish liturgical music.
"The two musicians will perform at the 19,000-seat arena on Feb. 28 in an event where food carts will feature glatt kosher food and a special section will most likely be set up with separate seating for men and women, to accommodate the customs of ultra-Orthodox Jews, who make up a sizable share of the Jewish population of Brooklyn," according to
The Times
Mr. Ratner tells that newspaper that Brooklyn has a storied tradition of "chazzanut" — the cantorial singing largely centered around synagogue prayers.
The Times
says Yossele Rosenblatt, known as the Jewish Caruso, led prayers at First Congregation Anshe Sfard in Borough Park in the 1920s and 1930s and the legendary Moshe Koussevitzky was the cantor at Temple Beth El in Borough Park in the 1950s and 1960s.
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Metastatic Breast Cancer Support Group for Women
Peer Support
Support groups provide a safe environment where cancer patients can talk about living with cancer with others that may be having similar experiences. Support groups give people a chance to ease fears and share strengths. Scripps offers a number of support groups to help you to:
- Maintain a positive attitude and take an active role in the recovery process
- Cope with chemotherapy, radiation therapy and the side effects of treatment
- Talk about cancer to family members, friends and co-workers
- Deal effectively with doctors and hospitals
- Regain a sense of control
- Maximize your potential for healing
This group is open to women in the entire San Diego community (non-Scripps patients are welcome) as part of our educational, community outreach program.
Topics address the particular concerns of women dealing with advanced breast cancer, including:
- Treatment decisions
- Side effects of treatment
- Work-related issues
- Changing relationships with children, spouses/partners, family and friends
- End-of-life concerns
Facilitators: Bev Mangerich, RN, MSN; Paula Thomas MSW, ACSW
- Scripps Polster Breast Care Center
- 9850 Genesee Ave.
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|Tuesday, April 9th, 2013
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Kimchi Jjigae (Pork and Kimchi Stew)
I was searching the web for recipes that used kimchi and I found several for Kimchi Jjigae or kimchi stew. The main recipes that I found were for pork and kimchi stew. I saw some variations of this dish that replaced the pork with canned tuna (which sounds good) and and some that used tofu in addition to the pork. Many of the recipes called for gochujang which is a spicy Korean condiment made of fermented soy beans, rice and chili powder. Keep in mind that both the kimchi and the gochujang are spiced with chili powder so be careful with the amounts that you use if you do not like it really hot. This stew was pretty easy to make and it was really tasty. I have really enjoyed the few Korean dishes that I have tried so far. I am going to have to start looking for a Korean cookbook.
1 teaspoon sesame oil
1/2 pound pork belly (cut into bite sized pieces) - samgyeopsal
2 cloves garlic (chopped)
2 cups dashi (or water)
1 cup kimchi (cut into bite sized pieces)
2 tablespoons gochujang
1 tablespoon gochugaru
1/2 package tofu (cut into bite sized pieces)
1 small onion (sliced)
1 cup zucchini (cut into bite sized pieces)
2 green chilies (sliced)
2 green onions (sliced)
1. Heat the oil in a large sauce pan.
2. Add the pork and saute until it is no longer pink, about 5-7 minutes.
3. Add the garlic and saute until fragrant, about a minute.
4. Add the kimchi and water bring to a boil.
5. Mix in the gochujang and gochugaru and simmer for 20 minutes.
6. Add the tofu, onion, zucchini and chilies and simmer until tender, about 5 minutes.
7. Remove from heat and add the green onions.
Similar Recipes:
Kimchi Bokkeumbap (Kimchi Fried Rice)
Kimchi Quesadillas
Bibim Guksu (Soba and Kimchi Salad)
Sauerkraut Cabbage Roll Soup
More soup recipes!


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Damage to Liberty State Park post Hurricane Sandy
Friday, November 16, 2012 2:14 PM
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Damage to a playground and picnic area at Liberty State Park is photographed on Friday, Nov. 16, 2012. Lauren Casselberry/The Jersey Journal
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- Volunteers meeting today to start cleanup of Liberty State Park in Jersey City November 17, 2012, 11:14 AM
- North side of Liberty State Park reopened November 29, 2012, 10:14 AM


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Yes, its super silly and my kids made fun of me for watching but I don't care.
This is brought to you by Ylvis, that same guy who wondered a while back what foxes say.
I love when cool technology comes together.
Huntsville, Ontario resident, Ben Carlin started up a new company this past Spring called Intrepid360 with the aim to combine 360 degree video and marketing.
He recently partnered up with Algonquin Outfitters to demonstrate the immersive and very powerful form of video by taking us on a family canoe day trip in Algonquin Park. You might recognize blogger, Jennifer Johnson and her family from the site, Backcountry with the Kids.
Watch the video below, move your mouse around and visit Algonquin Park in just over 3 minutes.
I love this old footage from 1949 showing the demonstration of a game of canoe polo at a local boat regatta. To both the untrained and trained eye it looks like total chaos but at the same time a serious boatload of fun.
Facing Waves is a new paddling and travel web TV show that you should check out on the YouTube. Hosted by Ken Whiting, Facing Waves highlights some of the awesome places to paddle around North America such as the Ottawa River, up north on the Hood River, Georgian Bay and Baja.
I was really excited to hear that their latest episode features my buddy, Ray Boucher who was working for Naturally Superior Adventures last fall when the episode was shot. In the latest segment, Ken and Ray head out to explore the gorgeous coastline of Lake Superior Provincial Park but along the way they ended up having an encounter with a bear which almost cut their trip short.
It's been out for a couple of years since Birthright was released but I still think that this is one of the most inspiring kayak films out there. If you haven't seen it before, now is the time.
Vimeo's description:
One man's struggle to transcend.
This humble film is about a friend of mine named Michael and his daily ritual to find his natural self through surfing.
Each year the Colorado School of Mines hosts their annual Engineers' Days which is a celebration all the things nerdy university engineering students are into. The day involves a whole pile of stuff like soap box races, gold panning, mattress races and what I can only imagine as super awesome, a Tesla coil demonstration.
One of the great traditions of the event is the annual cardboard boat race down the local Clear Creek. The only rules are that the contestant teams must build their boat with a set amount of cardboard and tape and it must carry the while team down the raging class I moving water. Extra points are awarded for creativity, floatability and keeping upright at least until the finish line.
This year, two students decided that floating down a river was so last year and decided walking was the way to go. Just wait until they need to negotiate a very small waterfall
Go team AT-AT!
From the YouTube description:
Maritime New Zealand's (MNZ's) new advertising campaign harks back to the glory days of 1980s cop shows to show that, like bulletproof vests, lifejackets don't save people's lives unless they're worn. Police officers Brandon Reynolds & Joe Lyons head to the docks for a bust. Things don't go as planned...
The campaign draws on MNZ's latest research, which shows that men aged 40 plus are the least likely to zip up on the water. Black humour and '80s TV show nostalgia are used to deliver the deadly message that having a lifejacket on board won't save boaties or their mates if things go wrong. Being close to your lifejacket is like being close to your bulletproof vest -- it's just not close enough. People think if they have an accident, they'll have time to put their lifejacket on, but boating tragedies tell a different story....
For more information about summer boating safety, visit maritimenz.govt.nz/lifejackets
And for good measure here is the Starsky and Hutch opening that made me want to be a cop so bad…
If you find yourself racing somebody on the interstate and looking for that little bit of extra boost, make sure you bring your canoe paddle. The definitive proof is here that it really does make all the difference.
Here it the link to the original video. Just make sure you have your computer speakers turned down. It's a touch loud.
Here is a match burning in super slow motion. Now you know what happens every time you strike one to light the campfire.
Sometimes things don't work out the way you picture it but if you keep at it you will eventually be successful.
I read that in a fortune cookie at a Chinese buffet once.
Image capture and video from sixknots.net.


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Jalapeno Popper Dip
I had been coming across this recipe for jalapeno popper dip on sites like Big Red Kitchen for a while and I had just been itching to try it. I really like jalapeno poppers and this dip has all of the elements that make jalapeno poppers so good, from the jalapenos to the cream cheese and cheddar cheese to the crunchy bread crumb crust. With the temex kick that I have been on lately it was the perfect time to try this dip out. The jalapeno popper dip was easy to make and the results were great! I increased the amount of jalapenos and added some fresh jalapenos for even more jalapeno flavour and heat. The dip was nice and warm and gooey and oh so tasty! I really enjoyed the spicy cheesy dip and its crunchy topping and I will definitely be making it again. I served the jalapeno popper dip with lime tortilla chips for dipping.
Jalapeno Popper Dip
Servings: makes 4 servings
Prep Time: 10 minutes
Cook Time: 20 minutes
Total Time: 30 minutes
Printable Recipe
- 1 (8 ounce) package cream cheese, room temperature
- 1/2 cup mayonnaise
- 1/2 cup cheddar cheese, shredded
- 1/2 cup parmigiano reggiano (parmesan), grated
- 1 (4 ounce) can sliced jalapenos (pickled), drained
- 2 jalapeno peppers, chopped (optional)
- 1/4 cup panko bread crumbs
- 1/4 cup parmigiano reggiano (parmesan), grated
- Mix the cream cheese, mayonnaise, cheddar cheese, parmigiano reggiano and jalapenos in a bowl and pour into a baking dish.
- Mix the panko bread crumbs and parmigiano reggiano and sprinkle over the dip.
- Bake in a preheated 350F oven until the sides are bubbling and the cheese cheese has melted and turned golden brown on top, about 20 minutes.
Slow Cooker: Mix everything except the panko, place it in the slow cooker and cook until the cheese is nice and melted about 1-2 hours on high or 2-4 hours on low. Toast the panko and sprinkle it on top just before serving.
Tip: Add crumbled bacon for the bacon wrapped jalapeno popper version!
Similar Recipes:
Tasty Tailgate Party Recipes
Jalapeno Popper Dressing
Southwestern Grilled Chicken Jalapeno Popper Salad
Jalapeno Popper Corn Fritters
Jalapeno Popper Chicken Soup
Jalapeno Popper Deviled Eggs
More tailgate recipes!


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Or find a doctor at another Johns Hopkins Medicine Member Hospital:
Fred Lenz, MD
Professor of Neurological Surgery
Appointment Phone
Main Location
The Johns Hopkins HospitalView All Locations
Out of State Patients
Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)
International Patients
Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)
- A Earl Walker Professor, Director of Functional Neurosurgery.
- Professor of Neurological Surgery
- Professor of Neuroscience
Centers & Institutes
- Blaustein Pain Treatment Center
- Brain Stimulation Center
- Epilepsy Center
- Parkinson's Disease and Movement Disorders Center
Deep Brain Stimulation, Dystonia, Epilepsy, Neurosurgery, Parkinson's Disease, Tremor
Research Interests
Movement Disorders, Epilepsy, Pain.
Dr. Fred Lenz is the A. Earl Walker Professor of Neurosurgery at Johns Hopkins. He maintains a practice which includes a personal experience of more than 25 years and 1,500 functional procedures including implantation of Deep Brain Stimulation electrodes (Parkinson's, tremor, dystonia), and implantation cortical electrodes or resections for treatment of epilepsy.
- English
Society of Neurologic Surgeons.
Society for Neuroscience.
Additional Resources
Education +
- University of Toronto (TorontoOntario) (1988)
- University Of Toronto (TorontoON Canada) (1977)
- The Toronto Hospital / Neurosurgery (TorontoOntario) (1988)
- University Of Toronto / Surgery (TorontoON Canada) (1987)
- The Royal College of Physicians and Surgeons of Canada (Ottawa) (1988)
- Neurological Surgery, American Board of Neurological Surgery (1993)
Research & Publications +
Research Summary
Dr. Fred Lenz has conducted more than 20 years of NIH-funded research and extensive experience as a scientific editor and reviewer. He has written over one hundred manucripts on these subjects and trained many fellows from around the world.
Selected Publications View all on PubMed
Non-peer Review Publications:
Garonzik, I.M., Hua, S., Ohara, S., Lenz, F.A. Microelectrode recordings: Single cell and field potential recordings. In Microelectrodes in Movement Disorder surgery. Israel, Z. and Burchiel, K, Thieme Verlag:Wein, pp 249, 2004.
FA Lenz. Deep Brain Stimulation for Parkinsons Disease. Proceedings of the North American Neuromodulation Society, 9: 43-50, 2005.
C.A. Bagley, S. Ohara,H.C. Lawson, F.A. Lenz.Psychophysics of CNS pain-related activity: binary and analog channels and memory encoding. The Neuroscientist, 12:29-42, 2006.
W.S. Anderson, S. Ohara, H.C. Lawson, R-D. Treede, F.A. Lenz. Plasticity of pain-related neuronal activity in the human thalamus. Prog Br Res 157:353-354, 2006.
F.A.Lenz. Section Summary of the Neurosurgical Treatment of Pain. Section on the Neurosurgical Treatment of Pain. 1st edition, (ed. FA Lenz). Encyclopedia of Pain (eds. R. Schmidt and W.D.Willis), Springer Verlag:Berlin. 1327-1331, 2007.
FA Lenz, Neurosurgical Procedures for Neuropathic Pain In Pain (Section eds: TS Jensen, F Cervero). Handbook of Neurology. Eds. M. Aminoff, F. Boller, DF Swaab. Elsevier: Amsterdam. 81: 869-886, 2006.
Bagley, C.A., Garonzik, I.M., Lenz, F.A. Neck Pain. in Principles of Ambulatory Medicine. Edited by Barker, L.R., Burton, J.R., Zieve, P.D, Fiebach, N., Kern, D.A., Thomas P., Ziegelstein, R. Williams and Wilkins: New York, 1157-1164, 2007.
FA Lenz, Ablative procedures. In Parkinsons Disease and Related Disorders (Section ed: W Koller and E Melamed). Handbook of Neurology. Eds. M. Aminoff, F. Boller, DF Swaab. Elsevier: Amsterdam 84: 241-260, 2006.
H.C. Lawson, S Ohara, JD Greenspan, RC Coghill, FA Lenz. Neurophysiological Cingulate Pain Responses and neurosurgical pain interventions. In Cingulate Neurobiology & Disease. BA Vogt, editor, Oxford University Press. pp. 401-417, 2009.
WS Anderson, FA Lenz. Deep Brain Stimulation for Movement Disorders Nature Clinical Practice: Neurology . 2:1-11, 2006.
J.D. Greenspan, R-D Treede, R.R.Tasker, F.A. Lenz. Chapter 28, Central pain states. Bonicas Management of Pain. Eds. SM Fishman, JC Ballantyne, JP Rathmell.. Lippincott, Williams and Wilkens. pp 358-374, 2008.
R. Hurley, R, Lenz FA. The neurosurgical treatment of cancer pain. In: Cancer Pain: Assessment and Management. Second Edition, edited by E. D. Bruera and R. K. Portenoy. New York: Cambridge University press. pp 329-342, 2009.
W.S. Anderson, R.E. Clatterbuck, M.D, K. Kobayashi, J-H Kim, F.A. Lenz. Lesions versus implanted stimulators in functional neurosurgery. Springer-Verlag, Berlin. Textbook of Stereotactic and functional neurosurgery. edited by AM Lozano, PL Gildenberg, RR Tasker. pp 1349-1358, 2009.
K. Kobayashi, J-H Kim, W.S. Anderson, F.A. Lenz. Neurosurgical treatment of tremor. In R Winn ed, Youmans Neurological Surgery. Saunders: New York, Chapter 78, pp 932-937, 2011.
W.S. Anderson, K. Kobayashi, J-H Kim, F.A. Lenz. Thalamotomy. In C. Comella, Encyclopedia of Movement Disorders, Elsevier: New York. Chapter 527. 2011.
WS Anderson, J Winberry, CC Liu, C Shi, FA Lenz.Microelectrode Recordings in Neurosurgery. Contemporary Neurosurg. 23(3): 1-8, 2010.
MJ Dorsey, FA Lenz, Neurosurgical Treatment of Pain. In Eds M Koltzenburg, S.McMahon. 6th Edition of Wall and Melzack's Textbook of Pain. New York: Elsevier. Chapter 42, 2011.
J.Cheng, D.S. Veldhuijzen, J.D. Greenspan, and F.A. Lenz. Deconstructing Central Pain With Psychophysical and Neuroimaging studies. In Ed. P Bright, Neuroimaging volume 3. InTech publishing, Cambridge, UK. in press. ISBN 978-953-307-1400-4. 2011.
Academic Affiliations & Courses +
Activities & Honors +
HonorsMultiple Federal Grants and Named Lectureships.
The Grass Career Award of the Society of Neurological Surgeons.
Induction into the A Earl Walker Chair in Neurosurgery at Johns Hopkins University.
Videos & Media +
Meet Our Expert - Dr Frederick Lenz
Dr. Frederick Lenz focuses on neurosurgical surgery for the treatment of Parkinson's disease, essential tremor, dystonia (Deep Brain Stimulation) and epilepsy surgery.
Events +
Contact & Locations +
LocationsThe Johns Hopkins Hospital600 N. Wolfe StreetMeyer8-181Baltimore, MD 21287Phone: 410-955-2257Appointment Phone: 410-955-6406Fax: 410-287-8044Location MapJohns Hopkins Outpatient Center601 N. Caroline StreetBaltimore, MD 21287Appointment Phone: 410-955-6406Location Map
- Neurosurgery - Functional


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Posts tagged Geena Davis
Meet the Pro: Mathias Alan
It's April and that means it's time for us to introduce this month's new artist. Please meet celebrity makeup artist Mathias Alan! He has painted gorgeous faces and created eye-catching hair styles for Red Carpet beauties, television hosts, and commercial talent. I had the pleasure of catching up with Mathias and this Q+ A is just a quick snapshot into Mathias' world. You can learn more about him on his site www.mathias4makeup.com, but here's just one tidbit from the master: he considers tarte's dark circle defense the perfect cure for those puffy bags underneath your eyes. Hope you enjoy reading about Mathias, one of my favorite makeup artists.
Apr 19th


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»For more bus services, please search using the above Search Form
Founded in 2000, MakeMyTrip is the pioneer of the Online Travel Industry in India. MakeMyTrip is the dominant market leader with over 50% market share. To date, over two million customerss have bought travel services from MakeMyTrip.
How to book :Choose the city you are going from >> Choose the city you are going to >> Select your journey date >> Search >> Choose your bus >> Provide your name and contact details >> Pay using your Credit Card/Debit Card/Cash Card or Online bank account >> Print your ticket
»For more bus services, please search using the above Search Form
»For more bus services, please search using the above Bus Booking Widget
Bus Operators from Mumbai to Baroda are Gujarat Travels, Sardar Travels Mumbai, Jain Ashok Travels Mum, Eagle Travels, Neeta Travels, Patel Travels Mumbai, Lucky Travels, Arihant Abhishek Travels Mum, Maitreya Ashok Travels Mumbai, and many more.
The bus portal of Makemytrip is truly amazing. The idea is great and the ease with which I could look up the busses and their schedule was amazing. I selected the bus I wanted to travel in and pressed book and paid for it hassle free. There were plenty of payment methods available and the flow was seamless. The cherry on the cake was the ability to choose my seat. Kudos to the development team for their work.
Mansi Khanna
I travelled for my vacation and it was a great trip. I did my bus and also my hotel booking at makemytrip. I also got a cash back discount on my bus ticket and discount on my hotel. It was nice. I used redbus also but there was no hotel there. There are lot of offers and discounts and so it is nice to book online. And it is easy also.
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Mumbai, the financial capital of India, is a much-visited destination that has numerous flights and trains connecting it to the rest of the country, as well as efficient bus services within Maharashtra and to various neighbouring states. Many airline companies offer cheap air travel between Mumbai and the other metropolises of the country, with a variety of discounted air tickets being offered by even full-service airlines, apart from the low-cost carriers. If you prefer to travel in the comfort of trains, the ease with which you can buy a railway ticket on online reservations systems is an added advantage, as is the reliability of the Indian Railways. Bus tickets are readily available as well, with both government tourism boards and private operators offering bus bookings through a variety of means. Additionally in Mumbai, there are several cheap packages available from budget to luxury and star rated hotels, and you can make reservations for most of these via online booking.
Previously known as Baroda, Vadodara is the third largest city in Gujarat, and is located to the south-east of Ahmedabad. Also known as Sanskari Nagari, or City of Culture, Vadodara is home to the beautiful Lakshmi Vilas Palace and the Maharaja Sayajirao University of Baroda. The city is much frequented by travellers on both business and leisure, and offers a variety of transport options, such as flights, trains, and bus services. Vadodara is an important junction for the Indian Railways, and has electronic reservations systems in place. Online booking is also available for trains, as well as online bus bookings for bus tickets of both private and government operators of buses that serve Vadodara. Air travel is also a popular option to reach Vadodara, as many airlines offer cheap budget tickets. Vadodara is also sufficiently well-endowed with accommodations, ranging from budget to luxury hotels, most of which offer cheap packages.
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Online booking of Mumbai to Baroda Krishna Ashok Travels Mum Bus Tickets with MakeMyTrip.com. Online Bus Reservation, list of all the Buses running from Mumbai to Baroda with Bus terminals, schedule and timetable.


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|Regions:Dover/Somersworth -Great Bay - Rochester - Southern Maine
|Exeter Greenland Portsmouth New Castle Newington Stratham Rye
Go Mobile: http://mobile.fosters.com
Donate all year-round
Friday, February 15, 2013
With the holidays past, Foster's is continuing the publication of a list of nonprofit organizations needing help throughout the year in the Seacoast and Tri-City regions.
Goodwin Community Health needs yarn needed for volunteers to knit/crochet hats, mittens and scarfs to keep patients warm. Will also take unfinished projects that we can unravel and reuse the yarn. Contact is Carol Garlough, firstname.lastname@example.com; 603-749-2346, ext 543. Deadline: Ongoing need.
Barrington Food Pantry needs nonperishable items, frozen food, cash donations and people to join the Adopt a Family program. Contact: Richard P. Conway, 664-7679. Deadline: Year round needs.
Revolution Church Food Pantry of Rochester needs donations of all types of foods to help at the holidays and year round. Contact is: Joan Gagnon, 603-781-0165, 603-509-2383, (church) 603-332-0212. Deadline: Year round needs.
Tri-City Consumers Action Co-Operative in Rochester needs an LCD projector, bulletin boards (large and small), dry erase boards (large and extra large), laptop computer, easel paper, musical instruments, gift cards to Staples and Home Depot. Contact Martha Jo Hewitt, 603-948-1043. Deadline: Year round needs
RESTORE — Is seeking a large truck to collect donated building materials, appliances, cabinets and furniture. We're always looking for donations of building materials, kitchen and other cabinetry, flooring, outdoor landscaping materials, furniture and more. Contact Anne Phipps for more details at 603-750-3200. Pick ups may be scheduled for large items, or items may be dropped off at the store, 29 Fox Run Road, Newington. Hours are 9 a.m. — 5 p.m., Tuesday — Saturday. Receipts for tax purposes are provided for all donations. Donated materials are sold to the public at reduced prices. The store provides a green option by helping to keep usable items out of the landfills and a venue for the recycling and repurposing of materials. All proceeds are used to support the mission of Southeast NH Habitat for Humanity. Southeast NH Habitat for Humanity works to provide affordable housing options for families in need. Deadline: Year round needs.


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HOME New York Knicks Gear New York Knicks Ladies New York Knicks Ladies Shorts & Pants $20 to $40 (21 items) Product ID: 847708
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Order as many items as you like with our $6.99 flat rate shipping.
This item ships within one business day.
Order as many items as you like with our $6.99 flat rate shipping.
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A game can get you pretty riled up. When the on-court action gets intense, your heart feels like it could jump out of your chest and your skin feels like it's on fire. Take a deep breath, relax and remember: it's just a game. There's no shame in taking your Knicks seriously, but ya gotta simmer down, little lady! Take a chill pill and allow yourself to de-stress from all the b-ball commotion in the De-Stressed yoga pants. They're made out of a cotton/poly/spandex material, perfect for loungin' around the casa or workin' it on the treadmill. Plus, the distressed, rhinestone-accented NYK logo and location name printed on the left hip and metallic team name printed at the back of the roll-down waist will add a lovely touch of NY pride to your lax look. Don't let your worry get the best of you — we all know New York's gonna come out on top anyway!
- 55% Cotton/35% Polyester/10% Spandex
- Distressed & metallic foil screen print
- Imported
- No pockets
- Officially licensed Knicks pants
- Roll-down, elastic waist
- Size S has 32" inseam
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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