text:
Hall of Fame voter continues to write in Pete Rose because, um, it's cold in April
Dec 27, 2012, 9:30 AM EDT
Really, that pretty much sums up this guy's Hall of Fame column. Despite Pete Rose being ineligible and absent from the Hall of Fame ballot, Marc Maturo of the Rockland County Times — who has a Hall of Fame vote despite the fact he hasn't covered baseball for 27 years — writes in Pete Rose's name every year.
Why? Because how can baseball bar Pete Rose due to his lack of integrity when baseball itself lacks integrity? OK, I would at least give such a charge of hypocrisy a hearing. He starts with ticket prices being high, but ultimately all Maturo seems to be on about is how it gets cold in April and October:
And this is not to mention opening the season in weather better suited to curling than to baseball, and ending in weather also best suited to curling than to baseball. Baseball is, after all, "The Summer Game." But don't tell this to players seen in postseason dugouts sporting parkas, Trapper's hats and arctic hand warmers; and don't tell that to the very people who make it all possible, the suckers, er, fans, who also can be seen sporting Antarctic-like gear, wrapped wonderfully in blankets. Integrity my foot!
Also bugging him: no day games for the World Series. Then he goes back to complaining about "blizzard baseball." Then he makes his pro-Pete Rose case. Starting with this:
If we have to depend on Rose's word alone, there's good reason to accept it.
Given that Rose has spent over two decades lying his hustling butt off, I'm not sure why that is, but go read Maturo's column if you want to hear the case. It has mostly to do with the fact that Rose played hard and such.
Anyway, that's the latest from the BBWAA and its strange rules which allow guys who haven't covered baseball since the Reagan administration to vote for the Hall of Fame while denying that right to a huge number of active, working baseball writers.
Ichiro compares being a free agent to being a puppy in a pet shop
Mar 28, 2015, 11:25 PM EDT
Let Marlins outfielder Ichiro Suzuki tell you how being a free agent is like being a puppy in a pet shop.
Mariners prospect Victor Sanchez has died
Mar 28, 2015, 10:35 PM EDT
Promising Mariners pitching prospect Victor Sanchez died on Saturday night after he was involved in an unfortunate boating accident in February.
Nate Schierholtz opts out of contract with the Rangers
Mar 28, 2015, 10:10 PM EDT
Outfielder Nate Schierholtz is a free agent again, opting out of his contract with the Rangers after a disappointing spring showing.
Videos: Young talent on display as Bryce Harper homers and Mike Trout robs a homer
Mar 28, 2015, 9:05 PM EDT
Two baseball superstars put their talented display in spring training action on Saturday afternoon.
Jaime Garcia scratched from Sunday start due to shoulder setback
Mar 28, 2015, 8:05 PM EDT
More shoulder problems for Jaime Garcia, who has made 16 combined starts since the beginning of the 2013 season.
The Shane Victorino saga with Boston radio personalities continues
Mar 28, 2015, 7:15 PM EDT
Shane Victorino didn't like the way a pair of radio personalities in Boston interpreted his desire to see the Red Sox acquire Cole Hamels from the Phillies.
Giants catcher Matt Paré talks about the not-so-glamorous life in the minor leagues
Mar 28, 2015, 6:25 PM EDT
Giants minor league catcher Matt Paré discussed the thrifty lifestyles minor league players are forced into.
Video: Alex Rodriguez connects for his third home run of the spring
Mar 28, 2015, 5:30 PM EDT
Rodriguez is now batting .306 (11-for-36) with three home runs, a double and a .925 OPS across 15 games this spring.
Report: Mets talking contract extension with Lucas Duda
Mar 28, 2015, 5:18 PM EDT
Lucas Duda is coming off a breakout year with the Mets and the two sides are now discussing a contract extension.
Didi Gregorius suffers left wrist sprain, X-rays come back negative
Mar 28, 2015, 4:13 PM EDT
Gregorius injured his wrist Saturday while trying to dive for a ground ball in the second inning.
Felix Doubront granted his release by the Cubs
Mar 28, 2015, 3:40 PM EDT
Doubront really struggled during Cactus League action, allowing nine runs on 17 hits (including two home runs) in seven innings across four appearances.
Rangers acquire left-hander Sam Freeman from Cardinals
Mar 28, 2015, 2:51 PM EDT
Freeman owns a 3.33 ERA with a 61/34 K/BB ratio over 70 1/3 innings in the majors.
J.J. Hardy to undergo MRA on ailing shoulder
Mar 28, 2015, 2:15 PM EDT
The Orioles will already be without Matt Wieters on Opening Day as he makes his way back from Tommy John surgery and now suddenly J.J. Hardy's status is also in question.
Angels release veteran reliever Matt Lindstrom
Mar 28, 2015, 1:32 PM EDT
Lindstrom, who was in camp this spring on a minor league contract, posted an ugly 11.12 ERA and 5/4 K/BB ratio over 5 2/3 innings during Cactus League action.
Twins prospect Lewis Thorpe to undergo Tommy John surgery
Mar 28, 2015, 12:45 PM EDT
Thorpe, 19, owns a 2.80 ERA and 179/54 K/BB ratio over his first 157 2/3 innings in pro ball.
Video: Yordano Ventura throws seven no-hit innings in Cactus League start
Mar 28, 2015, 12:00 PM EDT
Yordano Ventura was recently named as the Royals' Opening Day starter and he had a heck of a tuneup in his latest Cactus League outing last night.
Blue Jays GM Alex Anthopoulos watched Jonathan Papelbon pitch Friday
Mar 28, 2015, 11:01 AM EDT
Phillies closer Jonathan Papelbon said last month that he would be interested in a trade to the Blue Jays and it appears that the possibility might still have some legs.
Mike Pelfrey not happy about move to bullpen
Mar 28, 2015, 10:11 AM EDT
Pelfrey owns an ugly 5.56 ERA in 34 starts dating back to 2013.
Christian Vazquez says he's nervous about his elbow
Mar 28, 2015, 9:30 AM EDT
An MRI showed "something" in Christian Vazquez's right elbow.
Carlos Gonzalez exits game with soreness in surgically-repaired knee
Mar 28, 2015, 8:57 AM EDT
This isn't what you want to hear with the start of the season just one week away.
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Viewing: Blog Posts Tagged with: sketchbook, Most Recent at Top [Help]
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Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
JacketFlap tags: drawing, sketchbook, Sketchcrawl, Urban Sketchers, watercolour, Add a tag
Blog: andrea joseph's sketchblog (Login to Add to MyJacketFlap)
JacketFlap tags: #MuseumWeek, AJ, andrea joseph, Andrea Joseph drawings, Ashton, Bolton, collection, collections, event sketcher, Hat Works, museum, Oldham, sketchbook, Stockport, Add a tag
Blog: Theodesign.com (Login to Add to MyJacketFlap)
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Blog: andrea joseph's sketchblog (Login to Add to MyJacketFlap)
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Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
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I tried using double-sided tape to stick the insert into the book at first. I figured that it would be less messy than PVA when trying to position the folded card, but it started to peel up after just a couple of hours, so I went back to PVA.
I glued the top flap first, positioned it (folded under) on the inside back cover - 5mm from the top and outside edge - then put it under a couple of books to dry (squeeze out and wipe any excess glue first!)
I did the bottom flap once the top was secure. One trick: I was aware of the potential for excess glue to squeeze out underneath at this stage, unseen, and accidentally glue the insert shut, so I slipped a strip of waste card in between, before pressing the glued flap down.
Again, put books on top to dry, or it springs up.
Many people use ribbon to fasten books. I didn't want to drill holes in the cover through, as it acts as a mini drawing board when I am using the book, so I wanted it unsullied. John came up with the Velcro system. I was going to buy Velcro tape, then discovered these nifty little guys:
The beauty of the Velcro is that, when the book is in use, if the unfastened strap gets in the way, you can detach it and stick it back on at 90 degrees. You don't lose it, but it doesn't keep flapping and springing around the edges your paper.
If you found this project useful and want to check out other handy posts, try using the Hot Tips label on the right. I add the label to anything I think might be helpful to other people. It's a bit of a mix, with other ways of home-binding sketchbooks, but also tips for building up an illustration folio, how to do a school visit, create a 'Flat Plan' to plan out a book, or how to use / where to buy particular art materials. All sorts.
Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
JacketFlap tags: hot tips, sketchbook, Add a tag
I started by cutting 2 pieces of book board: you need to allow 5mm more than your folded paper inner all round. I then cut 2 pieces of book cloth, allowing about 20mm overlap on three sides, but cutting it 20mm short on the spine edge. You stick the book cloth pieces to the boards (it's easier to apply the glue to the board, rather than the book cloth):
Then you do the endpapers. You would normally stick the paper to both sides but, in this case, the inside back cover is going to be completely obscured by the flap we need to make, to slip the paper insert into. You just need to cover the front. Measure a piece that is 4 - 5mm smaller than the front cover all round and stick it on.
You're nearly there now. I'll tell you how to make the card insert next time, as this is turning into a very long post.
Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
JacketFlap tags: hot tips, planning, sketchbook, Add a tag
Blog: Christina Wald's Design and Illustration Blog (Login to Add to MyJacketFlap)
JacketFlap tags: fairies, fairy tale, journal sketching, sketch, sketchbook, spring, urban sketching, Add a tag
|Unleashing the last spirits of winter
|The council is in session...
It is common mythology around the world of spirits being a part of everything... The world does awaken this time of year from a dormant state.
I can hardly wait to get outside to sketch!
|The Leaf Litter...
|Even at the Krohn Conservatory!
Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
JacketFlap tags: hot tips, residency, sketchbook, studio, Add a tag
Plus I also have to make a cover for the sketchbooks. Instead of individual covers for each book, which would take ages, I was given a great idea by my sketch-buddy Lucie Golton: a detachable cover which you use again and again. She made me one as a present a while back, so I can copy her system. Thanks so much Lucie!
Blog: Theodesign.com (Login to Add to MyJacketFlap)
JacketFlap tags: Music, sketchbook, Add a tag
Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
JacketFlap tags: Dr Sketchy, sketchbook, watercolour, Add a tag
I had been working at a school in Scunthorpe during the day, so unfortunately we were a bit late getting to the pub where the Dr Sketchy events are held. I like to get there first, so I can get a seat at the front, where you can see better. The organisers do allow for that problem though, by having the models roam the audience, posing around the room, often sitting at the tables amongst us:
I love the challenge of Dr Sketchy - so much to do in so little time. You can feel the concentration humming in the room. With multiple models at once, you often only get part done:
If you like the idea of Dr Sketchy and live in or near either Sheffield of Buxton, check out their Facebook page for future events. If you live further afield, try a bit of Google searching, as Dr Sketchy is a franchise, with groups around the UK and USA I believe.
Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
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Sorry it's been a week since I last looked in. I am working hard every day on my mural. I did get to escape the computer on Saturday though - everything stops for SketchCrawl day!
This month, Urban Sketchers Yorkshire met up with our counterparts in Nottingham, for a drawing day at Nottingham Castle. There were a few sketchers from the Manchester and Birmingham groups too, so it was really lovely to meet lots of new people.
Blog: Here in the Bonny Glen (Login to Add to MyJacketFlap)
JacketFlap tags: Art, art journals, art supplies, Danny Gregory, Koosje Koene, Lynda Barry, sketchbook, sketchbook skool, Add a tag
On Twitter, Kim asked if I had any advice for a family getting started with sketching and art journaling. Did I ever! I've Storified the conversation, if you'd like to see how it unfolded, but I'll recap it here as well.
@melissawiley we are a family just starting to open the door to sketching and art journals. any suggestions? thanks. pic.twitter.com/pBRyl9cMgD
— Kim (@ttfhim) February 17, 2015
My replies below, expanded a bit. Points #6 and 7 are the most important.
Yes, lots!
1) Koosje Koene's Draw Tip Tuesday videos. She also offers classes in drawing and art journaling. (Here's a post I wrote about her videos in November.)
2) Sign up for a free two-week trial at Creativebug and take Dawn Devries Sokol's Art Journaling class and Lisa Congdon's Basic Line Drawing. I wrote about how much Lisa's class inspired me in my "Learning in Public" post.
3) A bunch of books to inspire you: Lynda Barry's wonderful Syllabus; Danny Gregory's new Art Before Breakfast (it's a delight; I'll be reviewing it soon) and the much-beloved The Creative License; the Illustration School series; the "20 Ways to Draw a…" series; Claire Walker Leslie's Keeping a Nature Journal; the Usborne "I Can Draw" series. And a few more recommendations in this older post.
4) Maybe try a Sketchbook Skool course! They offer a free sample class (I mean klass) so you can get a taste of the magic.
5) Cathy Johnson videos. Rilla loves Cathy's art and her gentle delivery.
6) Most importantly! Really just dive in and do it—if you do it, the kids will follow. Mine truly love to see me working & playing in my sketchbook. Actually, Rose was just commenting on it today, before this Twitter conversation occurred. She said she has really enjoyed watching me start from scratch (so to speak) and work at learning to draw. They all seem to love to see me trying, making mistakes, learning, improving. My progress excites them almost as much as it does me.
7) The REALLY most important piece of advice I can give: Allow plenty of TIME and room for mess. Many parents say "I want my kids to be creative" but can't tolerate mess. Art is messy. Creativity is messy. You need space to leave work out and return to it. Supplies in easy reach. And big spans of time for messing around, staring into space, doodling, doing things that look unproductive. I can't emphasize enough how important this is to any creative process. Time and room.
When I'm writing a novel, my most intense work happens while I look like I'm doing nothing at all. Sitting and staring blankly, chewing my nails, or filling an entire page with tiny lines and spirals. This is my body getting out of the way so my brain can get down to the real work of creating.
And for the visual arts, these totally tactile pursuits, you've got to have a place to spread out your paints, your pencils, your small objects that make you itch to draw. You know what's nice and tidy and doesn't clutter a room? A cellphone. If you want them to spend less time staring at screens (I'm not knocking screens here, you know I love me some screen time), you've got to grant them some real estate.
With that in mind, I make a point of keeping art supplies in easy reach. We have a dedicated kitchen drawer for placemats, paper, paint supplies so even the youngest kids can help themselves. Jars of colored pencils & crayons on table, a sharpener on the kitchen counter, a stack of art books on the shelf nearby. I want them to have constant free access to art materials. It's also a good idea to keep a bag packed for outings. I described ours in this old GeekMom post.
8) And what materials do I recommend? For littles: good paper, cheap paints. I elaborated on my reasons in this post from several years back:
When my older kids were little, I read lots and lots about the benefits of providing children with really high quality art supplies. In some cases, I still agree: Prismacolor colored pencils are worlds better than your drugstore variety. The lead is so creamy and blendable. They're expensive but they last a long time—we're on our second set of 72 colors in over ten years.
But watercolors? Real watercolor paper makes a huge difference, but it's expensive; that's one reason I was so taken with Jenn's idea to cut it into smaller, postcard-sized pieces. But when it comes to the paints themselves, well, I've been the high-quality route, absorbed the persuasive literature that talks about rich pigments and translucent hues; bought the pricey tubes of red, yellow, blue; collected jars for mixing colors; watched my children squeeze out too much paint and gleefully swirl it into an expensive puddle of mud-colored glop.
Lesson learned. The 99 cent Roseart or Crayola sets work just fine. In fact, dare I say I think my preschoolers like them better? Mixing colors is fun, but there is nothing quite so appealing as that bright rainbow of pretty paint ovals all in a row. When Wonderboy and Rilla make a mess of their paints, Jane cleans them up with a rag and they're practically good as new.
For older kids—and for yourself!—my advice is to skip the student-grade watercolors and go right to artist quality. More expensive but the difference is immense. You can use the money you saved buying cheap paints for the preschoolers.
We're still addicted to Prismacolor pencils—no other brand will do for me. And I like Micron pens for line drawing. The ink is waterfast so you can paint over it (like my pumpkins in yesterday's post). I also picked up a few gel pens—white, silver, and gold—and Rilla has had unbelievable amounts of fun with them. I love the white one for writing on a dark surface, like on the tag of my pencil pouch here.
The sketchbook I just filled up was a Canson Mixed Media, 7×10 spiral bound. The size worked really well for me. I also have a small Moleskine journal with watercolor paper, but it feels so special I find myself hesitant to use it and reaching for the mixed media book instead. (I've just started a new one, same as the one I filled up.) That's my real playground, the place I'm not afraid to (in the words of my personal hero, Ms. Frizzle) "Take chances and make mistakes!" But I'm getting braver every day and the lovely paper in that Moleskine is calling to me.
I've also found I love doing my first rough sketches with a brown watercolor pencil, very lightly. I go over it with ink afterward and then, when I paint, the pencil just blends in and becomes shadow. I don't sketch this way every time, but for some reason it seems to free me up. I'm more daring with this pencil. It takes me to a confident place between graphite pencil—with its sometimes overly tempting eraser—and straight-to-ink, which is sometimes exhilarating and sometimes terrifying. The brown Aquarelle feels like my co-conspirator. I don't know how else to describe it. I have even starting making some first tentative stabs at portrait drawing, thanks to this pencil. (I tried a selfie-a-day project for a week. None of them looked much like me, but this attempt on day seven could maybe be a cousin?)
Guys, I still feel so shy about posting my drawings! I mean, I have so many friends who make their livings as illustrators—heck, one of them even just won the Caldecott! (GO DAN! SO THRILLED!) Do you know how nerve-wracking it is to know pros are looking at your rookie work? Of course you do. Because what I've learned is everyone feels that way. Even my most brilliant artist friends look at some other person's work and sigh wistfully, wishing they'd made that piece. I've seen it happen time and again. So bit by bit I'm getting brave enough to share my baby steps.
9) Okay, so you have your lovely sketchbook and drawing implements, now what to draw?? Well, I guarantee Koosje Koene's videos mentioned above will keep you and the kids busy for a good long while. There's also this wonderful Everyday Matters Challenge list at Danny Gregory's blog. 328 suggestions, so you're just about good through 2016. And Kortney tipped me off to this most excellent Lynda Barry post (in Rilla's words, I simply adore her) about keeping a visual diary.
10) And a last tidbit I almost forgot: A most beloved activity here (especially for Rilla and me) is to listen to audiobooks while sketching. Many of my happiest hours have been spent this way. We're especially fond of Roald Dahl while drawing. Nobody brings on the whimsy like Dahl.
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Blog: Here in the Bonny Glen (Login to Add to MyJacketFlap)
JacketFlap tags: Art, Butterflies, Gardening, garden notes, Monarch butterflies, sketchbook, Add a tag
Remember those pumpkins I said might be ripe in time for Christmas? More like Valentine's Day. We gave most of them away to a neighbor (who thanked us with pumpkin bread, so we came out ahead) but kept a couple to perpetuate the cycle. We'll ignore these and let Nature do her thing, and maybe we'll have some seeds sprouting earlier in the season this time around. In the meantime, I'm enjoying the jarring contrast of spring flowers and fall harvest.
Spotted two tiny caterpillars on the milkweed! Sadly, however, we also found a withered monarch chrysalis hanging on the fence with a pinprick hole in it. It looks like we're raising caterpillars for something's lunch. Not cool, Nature. Monarchs have enough to contend with these days.Add a Comment
Blog: Here in the Bonny Glen (Login to Add to MyJacketFlap)
JacketFlap tags: Art, Assorted and Sundry, Gardening, little happy lists, sketchbook, Add a tag
1. Leaving the house early yesterday morning, I spotted a pair of goldfinches feasting on the seeds of my basil—yes, another herb I forgot to pinch back, and now I'm glad
2. Pink milk and candy hearts
3. Saturday night ritual: art time with Rilla while the older girls watch TV with Scott (after the early-to-bed boys have conked out). This week, we binged on Cathy Johnson videos. Oh, I just love her, murmurs my girl.
4. Weeded the front-yard flower beds. Began, at any rate, and made good headway. After I mowed the other day, I discovered just how much is in bloom. Nasturtiums, coreopsis, sweet alyssum, snapdragons, viola, milkweed…Ellie said it's okay to talk about my flowers, hope you don't mind.
5. Set up a new palette and spent a good while testing colors with Rilla.
6. This one's a Big Happy: today I finished the last empty page in my very first complete sketchbook. I started it on August 30. Have drawn or painted almost every day since (even if only for a few minutes). Feeling pretty chuffed.Add a Comment
Blog: andrea joseph's sketchblog (Login to Add to MyJacketFlap)
JacketFlap tags: AJ, andrea joseph, Andrea Joseph drawings, Etsy, event sketcher, illustration, illustrator, illustrator for hire, Manchester, shop local, sketchbook, sketcher, small business, Add a tag
Blog: warrior princess dream (Login to Add to MyJacketFlap)
JacketFlap tags: 2015, art, butterflies, butterfly, drawing, illustrator, painting, sara burrier, sarabillustration, sketch, sketchbook, the daily sketch, watercolor, whimsical, Add a tag
Do you ever find yourself sitting and watching a butterfly, and then realize minutes have passed, finding yourself wondering why they are just so magical?
I do... all. the. time.
I'm drawn to art with butterflies (especially collage), I'm drawn to the colors, the way the wings flutter, their gentleness, their life stages and how we make that into a metaphor for life, all of it! I love them so much I even have a butterfly, a painted lady, tattooed on my right shoulder in memory of my grandmother...who also loved the butterfly.
But I am still drawn to the question of....why?
According to the light research I did from the Butterfly Conservation site, and other pages around the web, butterflies have two purposes in nature, aside from being beautiful.
They pollenate, and they are food.
Yep, they are at the bottom of the food chain. They're food for birds, mammals, and reptiles. Like, food for everyone. One of the most wondrous and beautiful visions on the planet get eaten more than anything else.
I'm not trying to depress you with this news. When you sit and think about it, here's what is concluded:
They are a source for life. They feed everyone protein, vitamins, and nourishment.
They pollenate flowers so that their seeds will spread and the earth can continue to give back.
They bring beauty and peace to us in our gardens.
They share color and pattern throughout a mostly green, brown, and blue environment.
And, they give us hope through their life stages of metamorphosis. A demonstration that we are all beautiful from the inside out, and if we are truly ourselves we will shine brightly.
They are a symbol of rebirth, to start anew because they do! They live two lives, one as a caterpillar, the other as a butterfly.
|"Birth of Twilight"
You find so many butterflies in my work because of these thoughts. They will always make me wonder, but I think the simplest answer, they are BEAUTIFUL, is why God put them here. Yes, they have a purpose, to nourish, but that is part of the beauty.
Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
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Unfortunately, because we wanted the project to span a single academic year, we set the start date as October 2015 - ages to wait when I'm so excited! In the meantime, we can at least start planning, so Professor Heath from The Morgan Centre came to the studio this week, for a meeting.
I have learnt that the main project I am working on is studying the effect the weather has on us Brits - more painting in the rain perhaps! Plus there is also a project around 'Dormant Things': objects we all own, which we don't need or even really want, but can't quite bear to throw away. Cellars, attics and bottom-drawers everywhere are packed with them.
Another couple of bits of research I might dip into are going to involve interviewing people on the streets of Manchester. One is about how people interact with public spaces and the other is looking at street fashion. That should be quite a challenge - my speed sketching will come into it's own!
I've also been commissioned separately to shadow their conference in July. The theme is 'Atmospheres' and they have some fantastic presentations booked in. It sounds like it is going to be fascinating, over and above the fun I am going to have recording it in my sketchbook. I will be co-delivering a presentation with Prof. Heath about our project and, as with the ASCEL conference, I will have a short slot on my own near the end, for showing what I have been drawing during the event and talking briefly about Urban Sketching.
Such a fun job. Can't wait.
Blog: andrea joseph's sketchblog (Login to Add to MyJacketFlap)
JacketFlap tags: AJ, andrea joseph, Andrea Joseph drawings, blue, brown and blue, collage, doodles, illustration, illustrator, ink, insects, moleskine, pen, sepia, shoes, sketchbook, Sketchbook Skool, spare Moley, Add a tag
And, another thing, the envelope spread is what can happen when something goes wrong on a page; collage. The best way to cover all of your mistakes.
Blog: warrior princess dream (Login to Add to MyJacketFlap)
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Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
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Blog: Adventures at Wilder Farm (Login to Add to MyJacketFlap)
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A sketch for today. May all of you out there creating, whatever form you choose, have a lovely day.
The post A Sketch for Today appeared first on Lita Judge.
Blog: Michelle Can Draw (Login to Add to MyJacketFlap)
JacketFlap tags: sketchbook, twelveprincesses, artstagram, illustration, Add a tag
Dog likes to lay down on my #sketchbook because she wants to be the centre of attention. #illustration #twelveprincesses #artstagramAdd a Comment
Blog: An Illustrator's Life For Me! (Login to Add to MyJacketFlap)
JacketFlap tags: drawing, sketchbook, Sketchcrawl, Urban Sketchers, Add a tag
So, I advertised that I would be spending the day drawing in local, quirky coffee shops, if anyone fancied joining me for a spot of sketching to mark the day and guess what? Loads of my sketch-buddies came to keep me company. Perfect.
The inside of a cafe is not always the most inspiring subject matter: I would sooner be out in the street drawing buildings, or up in the hills painting landscapes but, with snow on the ground, it was a wee bit chilly out there. Okay, I know some of my Urban Sketchers cousins are sufficiently hardy that they sketch in temperatures so cold they have problems with their watercolour freezing (yes, really), but I kind of want to keep my fingers and toes. Call me a softy.
After lunch we walked 100 yards to Strip the Willow, a great arts and crafts collective (where my aforementioned venture into the nice cake featured):
Then it was on to our final stop: the Electric Candlelight Cafe, with odd things on the walls:
There were cuckoo clocks too, but I couldn't fit them in.
We had a really sociable, laid-back time and were enjoying ourselves so much that we didn't venture home until 5.30. Because I was the one who planned the day, I made sure we finished up just a short walk from my house too - clever or what?
Blog: warrior princess dream (Login to Add to MyJacketFlap)
JacketFlap tags: candace camling, illustration, illustrator, ink, new york, pen, sahm, SCBWI, sketchbook, the daily sketch, Add a tag
I am so unbelievably blessed with some very open, honest, and funny girlfriends. I've always been one who struggles with friends, but as an adult, I believe I have some of the best and strongest relationships I never thought possible.
One of these friends is fellow illustrator and work from home mom, Candace Camling. We are so much a like, yet so very different, and I adore this about our relationship. We can be very honest, borderline offensive honest, and still want to talk to each other. I find this very special and I treasure it.
|"Explore all the World" illustration by Candace Camling
She's on her way to New York today for a very important trip. She's attending the SCBWI conference where she will be presenting her top notch portfolio to directors, editors, and participating in the illustrator event (sorry, I don't know ALL the details). She's on her way to the top as a children's book illustrator.
I thought of her this morning as she's beginning this fun adventure. I've been able to help her out with printing her portfolio, and I am very honored to be there for her. She helps me out by being my soundboard for those really rough days and nights all about being mom or struggling artist.
She's my light for today, reminding myself that you get what you put in. She puts in long hours, money, perseverance, and hope for her career, and I'm inspired by that.
Visit Candace's blog and her portfolio!!!
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Logan talks with Mental Supreme, Legendary Host of the Training Camp (Hip Hop) Open Mic which is held Every Tuesday night, at 9pm, at the Pyramid, 101 Ave A. Between E6th and E7th, NYC. Get there at 7:30pm to sign up if you want to spit. This week, we who Mental Supreme was most impressed with last night. He also hosts an open mic Sunday nights at 10pm @ Karma Lounge, 51 1st Ave. & E3rd St, NYC Call 347-249-9441 on Sunday before 7pm if you want to perform two songs.
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Antiques, Collectables, Lots of Misc. from primitives to mid-century, still unpacking things. 325 south 2nd Seward, NE 68434
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Chrysler November U.S. vehicle sales up 14 percent, estimated to be up 16 percent.
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Football: Brown puts his faith in midfield power
Saturday 04 September 1999
After the way in which a patched-up Scotland surrendered a two-goal lead in Prague in June, providing the Czech Republic with the points they needed to reach Euro 2000, Brown might have been forgiven for devising a safety- first strategy for what he terms the "trickiest" of their remaining assignments. After all, once Wednesday's match against Estonia in Tallinn is over, the Scots finish with eminently winnable home games against Bosnia and Lithuania.
Instead, the Scotland manager has opted to accentuate the positive. Heartened by the Republic of Ireland's defeat of Yugoslavia, whom he regards as technically similar but superior to Bosnia, Brown hinted yesterday at a midfield bristling with scoring potential and the ability to attack from wide positions. At the same time he will resist the temptation to reinforce his favoured three at the back.
To a selection likely to contain only four players who started in Prague - Colin Calderwood, David Weir, Billy Dodds, and Neil Sullivan, who keeps his place in goal despite Wimbledon's shaky start and the challenge of Jonathan Gould - Brown is certain to restore John Collins, David Hopkin, Craig Burley and Neil McCann in the engine room.
Collins, who has not played for Scotland for a year because of injury, boasts 11 international goals, making him the top scorer among the current squad. Hopkin and Burley have both proved their capacity to find the net for club and country, while McCann made a hugely promising first full appearance against the Czechs at Celtic Park in March.
With even the holding role occupied by a player renowned for his defensive- splitting passes, the 21-year-old Barry Ferguson, Brown was justified in describing it as "a team designed not to sit in and defend". He added: "We could have put in Paul Ritchie and Christian Dailly to shore things up, but that's not our style. We've got to be positive.
"We need not to lose, but I don't think we've really got the mentality to go out to defend and play on the counter-attack. If we went into a 2-0 lead this time then we've got the capability to tighten it up. It's a major boost having Colin Hendry, John Collins and Craig Burley back. If we'd had those three in Prague, we'd never have let that lead slip."
Brown's approach to the match is almost frivolous compared with his customary caution and pragmatism. His attitude may be informed both by the knowledge that, for once, he has virtually a full-strength squad and by Bosnia's apparent decline since their stunning wins over Italy and Denmark shortly after the painful breakaway from Yugoslavia.
Since then, Bosnia have lost to China and Malta, among others, the latter defeat in January prompting the appointment of Faruk Hadzibegic as coach. A defender when Yugoslavia drew in Glasgow during qualifying for Italia 90, Hadzibegic has been saying that Scotland regard victory as a formality in an attempt to fire up his players.
In fact, for all Brown's untypical bravado, he is anything but blase. "I understand Bosnia have been more consistent under the new coach," he said. "Before, they could be brilliant, like when they beat the Danes 3-0, though they could also get results like the 2-2 draw with the Faroe Islands, who missed a penalty too. We've just got to impose ourselves on them."
Scottish optimism has been encouraged by the news that Bosnia's outstanding midfielders, Real Madrid's Elvir Baljic and Bayern Munich's Hasan Salihamadzic, are injured and suspended respectively. However, they will still field a team largely comprised of players based abroad, including Coventry's Muhamed Konjic.
Konjic fought for Bosnia's freedom as an infantryman against invading Serbs and Croats. The first transfer fee he commanded, on leaving FC Sarajevo for NK Zagreb, was paid in food parcels. His home city still bears the scars of war, the bus which took Scotland from the airport to their hotel having passed the shells of bullet-riddled buildings.
The Bosnian team is, therefore, unlikely to want for national pride. At kick-off they stand just one goal behind the Scots, yet Brown remains bullish about achieving the desired results in their six-day mini-tour of the Balkans and the Baltics.
BOSNIA (Probable): Dedic (Zenica); Joldic (Sloboda), Hibic (Sevilla), Konjic (Coventry), Mujdza (Hajduk Split); Topic (Monza); Besirevic (Osijek), Barbarez (Borussia Dortmund), Halilovic (Altay); Kodro (Alaves), Bolic (Fenerbahce).
SCOTLAND (Probable): Sullivan (Wimbledon); Weir (Everton), Hendry (Rangers), Calderwood (Aston Villa); Hopkin (Leeds), Burley (Celtic), B Ferguson (Rangers), Collins (Everton), McCann (Rangers); Hutchison (Everton), Dodds (Dundee United).
Referee: N Levnikov (Russia).
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Team preview: Stephen F. Austin
Blue Ribbon Illustrated previews the 2003-04 college basketball season, exclusively on Insider.
Updated: November 6, 2003, 11:09 AM ETBlue Ribbon Yearbook
Editor's Note: Insider has teamed with Blue Ribbon College Basketball Yearbook, long known as the Bible of college basketball, to provide a comprehensive look at all 327 Division I teams.
Despite losing all-conference center Percy Green, Stephen F. Austin has a chance to complete some unfinished business in 2003-04.
Last season was bittersweet for SFA, which nearly did everything it needed to do in order to win the Southland's regular-season and tournament championship.
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- Adapt And Advance
- Duke and Gonzaga changed things up and moved on.
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- Louisville and Michigan State turned their seasons around in time to meet in the Elite Eight.
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STAMFORD, Conn. — There are plenty of holiday events on tap this weekend in Stamford as Hanukkah starts, as well as a paranormal investigation. Visit the Stamford Daily Voice's Events Page to see what else is going on in the city.
Friday, Dec. 7
Santa Comes To Tree Lighting: 6 p.m. The Bartlett Arboretum & Gardens will have Jolly Old St. Nick and Acabella performing at their annual tree lighting. The event is free and the arboretum is at 151 Brookdale Road.
Saturday, Dec. 8
Riseup Paranormal: 7 p.m. Riseup Paranormal will conduct a live investigation at the Palace Theater, 61 Atlantic St., Saturday night. Ticket prices are $107 apiece.
Sunday, Dec. 9
SoSTY Chanukah Fair: 10:30 a.m. Temple Sinai, 458 Lakeside Drive, will have games, crafts, and other events going on at its free carnival.
Add your own events to our calendar here.
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- 5 Snow Expected To Arrive By Tuesday Afternoon In Stamford


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text: Washington D.C. Engagement Photos 20 Jan 2015 Posted on January 20, 2015 by Heidi Jan 20 2015 Real Weddings East Coast, Engagement, Modern Wedding, Urban Washington DC Engagement Photos Around the National Mall Brace yourself–the following Washington DC engagement photos are filled with colorful and stylish charm. They're also preceded by a really great proposal story. You see, Brandon asked Vauneeka to marry him at the Lincoln Memorial... Read more »


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Previous Next
What stringed instrument do you most like to listen to?
Asked at Massachusetts Street on August 26, 2007
"The mandolin. It's got such a nice soft and unique sound to it."
"I guess it would have to be the acoustic guitar. People can do amazing things with it."
"I would say the cello, even though I played the violin. I just like the deep sound of it."
"The acoustic guitar. My wife and one of my daughters both play it. It's very soothing."
chet_larock 7 years, 7 months ago
a pedal steel.
Crossfire 7 years, 7 months ago
Lemmy on Bass. Very soothing...one more time.
trinity 7 years, 7 months ago
my man's awesomely wonderful lead electric guitar. he rocks. :)
kugrad 7 years, 7 months ago
Two guitars playing together, or 2 harps
Dorothy Hoyt-Reed 7 years, 7 months ago
Hammered dulcimer. Heavenly.
Flap Doodle 7 years, 7 months ago
12 string guitar.
toefungus 7 years, 7 months ago
I like the tiny violin the Commission brings out every time it needs money.
sourpuss 7 years, 7 months ago
A trombone with a string tied to it.
sgtwolverine 7 years, 7 months ago
I am a fan of the upright bass.
Also, I enjoy good acoustic guitar, probably partly because I've become acquainted with a man named Jason Dennie.
Mkh 7 years, 7 months ago
Kathy Getto 7 years, 7 months ago
Bob Bowman (Bowdog) upright bass.
lounger 7 years, 7 months ago
The Incredible Sitar!
Tychoman 7 years, 7 months ago
Either dulcimer or your mom's G-string. Pick one.
ms_canada 7 years, 7 months ago
I have a CD of the Belfast Harp Ensemble along with The Chieftans. It has some awesome musical renditions. I love it, in fact I think that the stringed instruments are my favourites. So many good ones mentioned today. Hammered dulcimer is particularily beautiful. My husband, being Ukrainian, we purchased an old record by a Ukrainian Bandura orchestra. I love it.
gogoplata 7 years, 7 months ago
emu 7 years, 7 months ago
Kathy Getto 7 years, 7 months ago
scenebooster (Anonymous) says:
Bob Bowman is out of control on that bass.
In a good way, right? I have known grinnin' Bob for many many years. Love his style.
Ben McDaniel 7 years, 7 months ago
Am I the only person who loves the viola?
Bill Chapman 7 years, 7 months ago
How about a mountain dulcimer? Anybody heard one of those? I know someone who has an electric mountain dulcimer and it definitely isn't a guitar!
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The Ruse
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Armed with the new album Midnight in the City, THE RUSE is taking epic rock to new heights. Expanding on the atmospheres of their first two albums these LA rockers have truly delivered their strongest album to date. From the punky new wave first moments of the opener Beautiful is Gone to the classic rock swagger of title track and album closer Midnight in the City, THE RUSE takes the listener for a night out on the town and doesn't bring them home until the sun comes up.
Read more about The Ruse on Last.fm.
User-contributed text is available under the Creative Commons By-SA License and may also be available under the GNU FDL.
Top SongsTotal plays on Last.fm over the last 6 months
- Apache - (3:25) - 821 plays
- LyricsOur love has come so far, but not at all.
I remember the start you cant recall.
By the time it was right, you didnt want to fall.
If its over, say its over...
Blindly, I let you destroy me!
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VivaCell-MTS lowers price for Syria calls
December 18, 2013 - 16:53 AMT
PanARMENIAN.Net - VivaCell-MTS announced that now calls to fixed and mobile networks of Syria via Distant Call service will cost AMD 50 instead of the previous AMD 90.
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Publications (27)130.65 Total impact
Article: Targeting neutrophils in ischemic stroke: translational insights from experimental studies.[Show abstract] [Hide abstract]
ABSTRACT: Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After stroke, neutrophils respond rapidly promoting blood-brain barrier disruption, cerebral edema, and brain injury. A surge of neutrophil-derived reactive oxygen species, proteases, and cytokines are released as neutrophils interact with cerebral endothelium. Neutrophils also are linked to the major processes that cause ischemic stroke, thrombosis, and atherosclerosis. Thrombosis is promoted through interactions with platelets, clotting factors, and release of prothrombotic molecules. In atherosclerosis, neutrophils promote plaque formation and rupture by generating oxidized-low density lipoprotein, enhancing monocyte infiltration, and degrading the fibrous cap. In experimental studies targeting neutrophils can improve stroke. However, early human studies have been met with challenges, and suggest that selective targeting of neutrophils may be required. Several properties of neutrophil are beneficial and thus may important to preserve in patients with stroke including antimicrobial, antiinflammatory, and neuroprotective functions.Journal of Cerebral Blood Flow & Metabolism advance online publication, 25 March 2015; doi:10.1038/jcbfm.2015.45.Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 03/2015; DOI:10.1038/jcbfm.2015.45 · 5.46 Impact Factor
Article: Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain.[Show abstract] [Hide abstract]
ABSTRACT: Ischemia, white matter injury, and Alzheimer's disease (AD) pathologies often co-exist in aging brain. How one condition predisposes to, interacts with, or perhaps causes the others remains unclear. To better understand the link between ischemia, white matter injury, and AD, adult rats were administered lipopolysaccharide (LPS) to serve as an inflammatory stimulus, and 24 h later subjected to 20-min focal cerebral ischemia (IS) followed by 30-min hypoxia (H). Myelin and axonal damage, as well as amyloid-β (Aβ) and amyloid-β protein precursor (AβPP) deposition were examined by western blot and immunocytochemistry following LPS/IS/H. Findings were compared to the 5XFAD mouse AD brain. Myelin/axonal injury was observed bilaterally in cortex following LPS/IS/H, along with an increase in IL-1, granzyme B, and LPS. AβPP deposition was present in ischemic striatum in regions of myelin loss. Aβ1-42 and AβPP were deposited in small foci in ischemic cortex that co-localized with myelin aggregates. In the 5XFAD mouse AD model, cortical amyloid plaques also co-localized with myelin aggregates. LPS/IS/H produce myelin injury and plaque-like aggregates of myelin. AβPP and Aβ co-localize with these myelin aggregates.Journal of Alzheimer's disease: JAD 03/2015; DOI:10.3233/JAD-143072 · 3.61 Impact Factor
Article: Myelin Basic Protein Associates with AβPP, Aβ1-42, and Amyloid Plaques in Cortex of Alzheimer's Disease Brain.[Show abstract] [Hide abstract]
ABSTRACT: The goal of this study was to show that myelin and axons in cortical gray matter are damaged in Alzheimer's disease (AD) brain. Superior temporal gyrus gray matter of AD patients (9 male, 14 female) was compared to cognitively normal controls (8 male, 7 female). Myelin basic protein (MBP) and a degraded myelin basic protein complex (dMBP) were quantified by Western blot. Brain sections were immunostained for MBP, dMBP, axonal neurofilament protein (NF), autophagy marker microtubule-associated proteins 1A/B light chain 3B precursor (LC3B), amyloid-β protein precursor (AβPP), and amyloid markers amyloid β1-42 (Aβ1-42) and FSB. Co-immunoprecipitation and mass spectroscopy evaluated interaction of AβPP/Aβ1-42 with MBP/dMBP. Evidence of axonal injury in AD cortex included appearance of AβPP in NF stained axons, and NF at margins of amyloid plaques. Evidence of myelin injury in AD cortex included (1) increased dMBP in AD gray matter compared to control (p < 0.001); (2) dMBP in AD neurons; and (3) increased LC3B that co-localized with MBP. Evidence of interaction of AβPP/Aβ1-42 with myelin or axonal components included (1) greater binding of dMBP with AβPP in AD brain; (2) MBP at the margins of amyloid plaques; (3) dMBP co-localized with Aβ1-42 in the core of amyloid plaques in AD brains; and (4) interactions between Aβ1-42 and MBP/dMBP by co-immunoprecipitation and mass spectrometry. We conclude that damaged axons may be a source of AβPP. dMBP, MBP, and NF associate with amyloid plaques and dMBP associates with AβPP and Aβ1-42. These molecules could be involved in formation of amyloid plaques.Journal of Alzheimer's disease: JAD 01/2015; 44(4):1213-29. DOI:10.3233/JAD-142013 · 3.61 Impact Factor
Article: Gene Expression in Peripheral Immune Cells following Cardioembolic Stroke Is Sexually Dimorphic[Show abstract] [Hide abstract]
ABSTRACT: Aims: Epidemiological studies suggest that sex has a role in the pathogenesis of cardioembolic stroke. Since stroke is a vascular disease, identifying sexually dimorphic gene expression changes in blood leukocytes can inform on sex-specific risk factors, response and outcome biology. We aimed to examine the sexually dimorphic immune response following cardioembolic stroke by studying the differential gene expression in peripheral white blood cells. Methods and Results: Blood samples from patients with cardioembolic stroke were obtained at <= 3 hours (prior to treatment), 5 hours and 24 hours (after treatment) after stroke onset (n = 23; 69 samples) and compared with vascular risk factor controls without symptomatic vascular diseases (n = 23, 23 samples) (ANCOVA, false discovery rate p <= 0.05, vertical bar fold change vertical bar >= 1.2). mRNA levels were measured on whole-genome Affymetrix microarrays. There were more up-regulated than down-regulated genes in both sexes, and females had more differentially expressed genes than males following cardioembolic stroke. Female gene expression was associated with cell death and survival, cell-cell signaling and inflammation. Male gene expression was associated with cellular assembly, organization and compromise. Immune response pathways were over represented at <= 3, 5 and 24 h after stroke in female subjects but only at 24 h in males. Neutrophil-specific genes were differentially expressed at 3, 5 and 24 h in females but only at 5 h and 24 h in males. Conclusions: There are sexually dimorphic immune cell expression profiles following cardioembolic stroke. Future studies are needed to confirm the findings using qRT-PCR in an independent cohort, to determine how they relate to risk and outcome, and to compare to other causes of ischemic stroke.PLoS ONE 07/2014; 9(7):e102550. DOI:10.1371/journal.pone.0102550 · 3.53 Impact Factor
Article: microRNA Expression in Peripheral Blood Cells following Acute Ischemic Stroke and Their Predicted Gene Targets[Show abstract] [Hide abstract]
ABSTRACT: Background: microRNA (miRNA) are important regulators of gene expression. In patients with ischemic stroke we have previously shown that differences in immune cell gene expression are present. In this study we sought to determine the miRNA that are differentially expressed in peripheral blood cells of patients with acute ischemic stroke and thus may regulate immune cell gene expression. Methods: miRNA from peripheral blood cells of forty-eight patients with ischemic stroke and vascular risk factor controls were compared. Differentially expressed miRNA in patients with ischemic stroke were determined by microarray with qRT-PCR confirmation. The gene targets and pathways associated with ischemic stroke that may be regulated by the identified miRNA were characterized. Results: In patients with acute ischemic stroke, miR-122, miR-148a, let-7i, miR-19a, miR-320d, miR-4429 were decreased and miR-363, miR-487b were increased compared to vascular risk factor controls. These miRNA are predicted to regulate several genes in pathways previously identified by gene expression analyses, including toll-like receptor signaling, NF-kappa b signaling, leukocyte extravasation signaling, and the prothrombin activation pathway. Conclusions: Several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA may regulate leukocyte gene expression in ischemic stroke including pathways involved in immune activation, leukocyte extravasation and thrombosis.PLoS ONE 06/2014; 9(6):e99283. DOI:10.1371/journal.pone.0099283 · 3.53 Impact Factor
Article: Distinctive RNA Expression Profiles in Blood Associated With Alzheimer Disease After Accounting for White Matter Hyperintensities.[Show abstract] [Hide abstract]
ABSTRACT: Defining the RNA transcriptome in Alzheimer Disease (AD) will help understand the disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH. RNA from whole blood was processed on whole-genome microarrays. A total of 293 probe sets were differentially expressed in AD versus controls, 5 of which were significant for WMH status. The 288 AD-specific probe sets classified subjects with 87.5% sensitivity and 90.5% specificity. They represented 188 genes of which 29 have been reported in prior AD blood and 89 in AD brain studies. Regulated blood genes included MMP9, MME (Neprilysin), TGFβ1, CA4, OCLN, ATM, TGM3, IGFR2, NOV, RNF213, BMX, LRRN1, CAMK2G, INSR, CTSD, SORCS1, SORL1, and TANC2. RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain.Alzheimer disease and associated disorders 04/2014; DOI:10.1097/WAD.0000000000000022 · 2.88 Impact Factor
Article: Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury.[Show abstract] [Hide abstract]
ABSTRACT: Traumatic brain injury (TBI) is often associated with intracerebral and intraventricular hemorrhage. Thrombin is a neurotoxin generated at bleeding sites following TBI, and can lead to cell death and subsequent cognitive dysfunction via activation of Src family kinases (SFKs). We hypothesize that inhibiting SFKs can protect hippocampal neurons and improve cognitive memory function following TBI. To test these hypotheses we show that moderate lateral fluid percussion (LFP) TBI in adult rats produces bleeding into the cerebrospinal fluid (CSF) in both lateral ventricles, which elevates oxyhemoglobin and thrombin levels in CSF, activates the SFK family member Fyn, and increases Rho-kinase 1(ROCK1) expression. Systemic administration of the SFK inhibitor, PP2, immediately following moderate TBI blocks ROCK1 expression, protects hippocampal CA2-3 neurons, and improves spatial memory function. These data suggest the possibility that inhibiting SFKs following TBI might improve clinical outcomes.Journal of neurotrauma 01/2014; DOI:10.1089/neu.2013.3250 · 4.25 Impact Factor
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ABSTRACT: Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are needed. In this review, we summarize studies of HT in both animals and humans. We propose that early HT (<18 to 24 hours after stroke onset) relates to leukocyte-derived matrix metalloproteinase-9 (MMP-9) and brain-derived MMP-2 that damage the neurovascular unit and promote blood-brain barrier (BBB) disruption. This contrasts to delayed HT (>18 to 24 hours after stroke) that relates to ischemia activation of brain proteases (MMP-2, MMP-3, MMP-9, and endogenous tissue plasminogen activator), neuroinflammation, and factors that promote vascular remodeling (vascular endothelial growth factor and high-moblity-group-box-1). Processes that mediate BBB repair and reduce HT risk are discussed, including transforming growth factor beta signaling in monocytes, Src kinase signaling, MMP inhibitors, and inhibitors of reactive oxygen species. Finally, clinical features associated with HT in patients with stroke are reviewed, including approaches to predict HT by clinical factors, brain imaging, and blood biomarkers. Though remarkable advances in our understanding of HT have been made, additional efforts are needed to translate these discoveries to the clinic and reduce the impact of HT on patients with ischemic stroke.Journal of Cerebral Blood Flow & Metabolism advance online publication, 27 November 2013; doi:10.1038/jcbfm.2013.203.Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 11/2013; DOI:10.1038/jcbfm.2013.203 · 5.46 Impact Factor
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ABSTRACT: OBJECTIVE: Hemorrhagic transformation (HT) is a major complication of ischemic stroke that worsens outcomes and increases mortality. Disruption of the blood brain barrier is a central feature to HT pathogenesis, and leukocytes may contribute to this process. We sought to determine whether ischemic strokes that develop HT have differences in RNA expression in blood within 3 hours of stroke onset prior to treatment with thrombolytic therapy. METHODS: Stroke patient blood samples were obtained prior to treatment with thrombolysis, and leukocyte RNA assessed by microarray analysis. Strokes that developed HT (n=11) were compared to strokes without HT (n=33) and controls (n=14). Genes were identified (corrected p-value <0.05, fold change ≥|1.2|) and functional analysis performed. RNA prediction of HT in stroke was evaluated using cross-validation, and in a second stroke cohort (n=52). RESULTS: Ischemic strokes that developed HT had differential expression of 29 genes in circulating leukocytes prior to treatment with thrombolytic therapy. A panel of 6 genes could predict strokes that later developed HT with 80% sensitivity and 70.2% specificity. Key pathways involved in HT of human stroke are described, including amphiregulin, a growth factor that regulates matrix metalloproteinase-9; a shift in transforming growth factor-beta signaling involving SMAD4, INPP5D and IRAK3; and a disruption of coagulation factors V and VIII. INTERPRETATION: Identified genes correspond to differences in inflammation and coagulation that may predispose to HT in ischemic stroke. Given the adverse impact of HT on stroke outcomes, further evaluation of the identified genes and pathways is warranted to determine their potential as therapeutic targets to reduce HT and as markers of HT risk. ANN NEUROL 2010.Annals of Neurology 09/2013; 74(2). DOI:10.1002/ana.23883 · 11.91 Impact Factor
Article: Prediction of Cardioembolic, Arterial, and Lacunar Causes of Cryptogenic Stroke by Gene Expression and Infarct Location[Show abstract] [Hide abstract]
ABSTRACT: The cause of ischemic stroke remains unclear, or cryptogenic, in as many as 35% of patients with stroke. Not knowing the cause of stroke restricts optimal implementation of prevention therapy and limits stroke research. We demonstrate how gene expression profiles in blood can be used in conjunction with a measure of infarct location on neuroimaging to predict a probable cause in cryptogenic stroke. The cause of cryptogenic stroke was predicted using previously described profiles of differentially expressed genes characteristic of patients with cardioembolic, arterial, and lacunar stroke. RNA was isolated from peripheral blood of 131 cryptogenic strokes and compared with profiles derived from 149 strokes of known cause. Each sample was run on Affymetrix U133 Plus 2.0 microarrays. Cause of cryptogenic stroke was predicted using gene expression in blood and infarct location. Cryptogenic strokes were predicted to be 58% cardioembolic, 18% arterial, 12% lacunar, and 12% unclear etiology. Cryptogenic stroke of predicted cardioembolic etiology had more prior myocardial infarction and higher CHA(2)DS(2)-VASc scores compared with stroke of predicted arterial etiology. Predicted lacunar strokes had higher systolic and diastolic blood pressures and lower National Institutes of Health Stroke Scale compared with predicted arterial and cardioembolic strokes. Cryptogenic strokes of unclear predicted etiology were less likely to have a prior transient ischemic attack or ischemic stroke. Gene expression in conjunction with a measure of infarct location can predict a probable cause in cryptogenic strokes. Predicted groups require further evaluation to determine whether relevant clinical, imaging, or therapeutic differences exist for each group.Stroke 05/2012; 43(8):2036-41. DOI:10.1161/STROKEAHA.111.648725 · 6.02 Impact Factor
Article: Y Chromosome Gene Expression in the Blood of Male Patients With Ischemic Stroke Compared With Male Controls[Show abstract] [Hide abstract]
ABSTRACT: Sex is suggested to be an important determinant of ischemic stroke risk factors, etiology, and outcome. However, the basis for this remains unclear. The Y chromosome is unique in males. Genes expressed in males on the Y chromosome that are associated with stroke may be important genetic contributors to the unique features of males with ischemic stroke, which would be helpful for explaining sex differences observed between men and women. We compared Y chromosome gene expression in males with ischemic stroke and male controls. Blood samples were obtained from 40 male patients ≤3, 5, and 24 hours after ischemic stroke and from 41 male controls (July 2003-April 2007). RNA was isolated from blood and was processed using Affymetrix Human U133 Plus 2.0 expression arrays (Affymetrix Inc., Santa Clara, California). Y chromosome genes differentially expressed between male patients with stroke and male control subjects were identified using an ANCOVA adjusted for age and batch. A P < 0.05 and a fold change >1.2 were considered significant. Seven genes on the Y chromosome were differentially expressed in males with ischemic stroke compared with controls. Five of these genes (VAMP7, CSF2RA, SPRY3, DHRSX, and PLCXD1) are located on pseudoautosomal regions of the human Y chromosome. The other 2 genes (EIF1AY and DDX3Y) are located on the nonrecombining region of the human Y chromosome. The identified genes were associated with immunology, RNA metabolism, vesicle fusion, and angiogenesis. Specific genes on the Y chromosome are differentially expressed in blood after ischemic stroke. These genes provide insight into potential molecular contributors to sex differences in ischemic stroke.Gender Medicine 02/2012; 9(2):68-75.e3. DOI:10.1016/j.genm.2012.01.005 · 1.55 Impact Factor
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ABSTRACT: Deciphering whether a transient neurological event (TNE) is of ischemic or nonischemic etiology can be challenging. Ischemia of cerebral tissue elicits an immune response in stroke and transient ischemic attack (TIA). This response, as detected by RNA expressed in immune cells, could potentially distinguish ischemic from nonischemic TNE. Analysis of 208 TIAs, ischemic strokes, controls, and TNE was performed. RNA from blood was processed on microarrays. TIAs (n=26) and ischemic strokes (n=94) were compared with controls (n=44) to identify differentially expressed genes (false discovery rate <0.05, fold change ≥1.2). Genes common to TIA and stroke were used predict ischemia in TIA diffusion-weighted imaging-positive/minor stroke (n=17), nonischemic TNE (n=13), and TNE of unclear etiology (n=14). Seventy-four genes expressed in TIA were common to those in ischemic stroke. Functional pathways common to TIA and stroke related to activation of innate and adaptive immune systems, involving granulocytes and B cells. A prediction model using 26 of the 74 ischemia genes distinguished TIA and stroke subjects from control subjects with 89% sensitivity and specificity. In the validation cohort, 17 of 17 TIA diffusion-weighted imaging-positive/minor strokes were predicted to be ischemic, and 10 of 13 nonischemic TNE were predicted to be nonischemic. In TNE of unclear etiology, 71% were predicted to be ischemic. These subjects had higher ABCD(2) scores. A common molecular response to ischemia in TIA and stroke was identified, relating to activation of innate and adaptive immune systems. TNE of ischemic etiology was identified based on gene profiles that may be of clinical use once validated.Stroke 02/2012; 43(4):1006-12. DOI:10.1161/STROKEAHA.111.638577 · 6.02 Impact Factor
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ABSTRACT: This study examined the effects of gender on RNA expression after ischemic stroke (IS). RNA obtained from blood of IS patients (n=51; 153 samples at < or =3, 5, and 24 hours) and from matched controls (n=52) were processed on Affymetrix microarrays. Analyses of covariance for stroke versus control samples were performed separately for both genders and the regulated genes for females compared with males. In all, 242, 227, and 338 male-specific genes were regulated at < or =3, 5, and 24 hours after IS, respectively, of which 59 were regulated at all time points. Overall, 774, 3,437, and 571 female-specific stroke genes were regulated at < or =3, 5, and 24 hours, respectively, of which 152 were regulated at all time points. Male-specific stroke genes were associated with integrin, integrin-liked kinase, actin, tight junction, Wnt/β-catenin, RhoA, fibroblast growth factors (FGF), granzyme, and tumor necrosis factor receptor (TNFR)2 signaling. Female-specific stroke genes were associated with p53, high-mobility group box-1, hypoxia inducible factor (HIF)1α, interleukin (IL)1, IL6, IL12, IL18, acute-phase response, T-helper, macrophage, and estrogen signaling. Cell death signaling was overrepresented in both genders, although the molecules and pathways differed. Gender affects gene expression in the blood of IS patients, which likely implies gender differences in immune, inflammatory, and cell death responses to stroke.Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 12/2011; 32(5):780-91. DOI:10.1038/jcbfm.2011.179 · 5.46 Impact Factor
Article: The X-Chromosome Has a Different Pattern of Gene Expression in Women Compared With Men With Ischemic Stroke[Show abstract] [Hide abstract]
ABSTRACT: Differences in ischemic stroke between men and women have been mainly attributed to hormonal effects. However, sex differences in immune response to ischemia may exist. We hypothesized that differential expression of X-chromosome genes in blood immune cells contribute to differences between men and women with ischemic stroke. RNA levels of 683 X-chromosome genes were measured on Affymetrix U133 Plus2.0 microarrays. Blood samples from patients with ischemic stroke were obtained at ≤ 3 hours, 5 hours, and 24 hours (n=61; 183 samples) after onset and compared with control subjects without symptomatic vascular diseases (n=109). Sex difference in X-chromosome gene expression was determined using analysis of covariance (false discovery rate ≤ 0.05, fold change ≥ 1.2). At ≤ 3, 5, and 24 hours after stroke, there were 37, 140, and 61 X-chromosome genes, respectively, that changed in women; and 23, 18, and 31 X-chromosome genes that changed in men. Female-specific genes were associated with post-translational modification, small-molecule biochemistry, and cell-cell signaling. Male-specific genes were associated with cellular movement, development, cell-trafficking, and cell death. Altered sex specific X-chromosome gene expression occurred in 2 genes known to be associated with human stroke, including galactosidase A and IDS, mutations of which result in Fabry disease and Hunter syndrome, respectively. There are differences in X-chromosome gene expression between men and women with ischemic stroke. Future studies are needed to decipher whether these differences are associated with sexually dimorphic immune response, repair or other mechanisms after stroke, or whether some of them represent risk determinants.Stroke 11/2011; 43(2):326-34. DOI:10.1161/STROKEAHA.111.629337 · 6.02 Impact Factor
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ABSTRACT: Determining which small deep infarcts (SDIs) are of lacunar, arterial, or cardioembolic etiology is challenging, but important in delivering optimal stroke prevention therapy. We sought to distinguish lacunar from nonlacunar causes of SDIs using a gene expression profile. A total of 184 ischemic strokes were analyzed. Lacunar stroke was defined as a lacunar syndrome with infarction <15mm in a region supplied by penetrating arteries. RNA from blood was processed on whole genome microarrays. Genes differentially expressed between lacunar (n = 30) and nonlacunar strokes (n = 86) were identified (false discovery rate ≤ 0.05, fold change >|1.5|) and used to develop a prediction model. The model was evaluated by cross-validation and in a second test cohort (n = 36). The etiology of SDIs of unclear cause (SDIs ≥ 15mm or SDIs with potential embolic source) (n = 32) was predicted using the derived model. A 41-gene profile discriminated lacunar from nonlacunar stroke with >90% sensitivity and specificity. Of the 32 SDIs of unclear cause, 15 were predicted to be lacunar, and 17 were predicted to be nonlacunar. The identified profile represents differences in immune response between lacunar and nonlacunar stroke. Profiles of differentially expressed genes can distinguish lacunar from nonlacunar stroke. SDIs of unclear cause were frequently predicted to be of nonlacunar etiology, suggesting that comprehensive workup of SDIs is important to identify potential cardioembolic and arterial causes. Further study is required to evaluate the gene profile in an independent cohort and determine the clinical and treatment implications of SDIs of predicted nonlacunar etiology.Annals of Neurology 09/2011; 70(3):477-85. DOI:10.1002/ana.22497 · 11.91 Impact Factor
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ABSTRACT: Whole genome expression microarrays can be used to study gene expression in blood, which comes in part from leukocytes, immature platelets, and red blood cells. Since these cells are important in the pathogenesis of stroke, RNA provides an index of these cellular responses to stroke. Our studies in rats have shown specific gene expression changes 24 hours after ischemic stroke, hemorrhage, status epilepticus, hypoxia, hypoglycemia, global ischemia, and following brief focal ischemia that simulated transient ischemic attacks in humans. Human studies show gene expression changes following ischemic stroke. These gene profiles predict a second cohort with >90% sensitivity and specificity. Gene profiles for ischemic stroke caused by large-vessel atherosclerosis and cardioembolism have been described that predict a second cohort with >85% sensitivity and specificity. Atherosclerotic genes were associated with clotting, platelets, and monocytes, and cardioembolic genes were associated with inflammation, infection, and neutrophils. These gene profiles predicted the cause of stroke in 58% of cryptogenic patients. These studies will provide diagnostic, prognostic, and therapeutic markers, and will advance our understanding of stroke in humans. New techniques to measure all coding and noncoding RNAs along with alternatively spliced transcripts will markedly advance molecular studies of human stroke.Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 07/2011; 31(7):1513-31. DOI:10.1038/jcbfm.2011.45 · 5.46 Impact Factor
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ABSTRACT: A blood test to detect stroke and its causes would be particularly useful in babies, young children, and patients in intensive care units and for emergencies when imaging is difficult to obtain or is unavailable. Whole genome microarrays were used to show specific gene expression profiles in rats 24 hours after ischemic and hemorrhagic stroke, hypoxia, and hypoglycemia. These proof-of-principle studies revealed that groups of genes (called gene profiles) can distinguish ischemic stroke patients from controls within 3 to 24 hours after the strokes. In addition, gene expression profiles have been developed that distinguish stroke due to large-vessel atherosclerosis from cardioembolic stroke. These profiles will be useful for predicting the causes of cryptogenic stroke. The results in adults suggest that similar diagnostic tools could be developed for children.Journal of child neurology 06/2011; 26(9):1131-6. DOI:10.1177/0883073811408093 · 1.59 Impact Factor
Article: GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: A pilot study[Show abstract] [Hide abstract]
ABSTRACT: Tourette syndrome (TS) is a complex childhood neurodevelopmental disorder characterized by motor and vocal tics. Recently, altered numbers of GABAergic-parvalbumin (PV) and cholinergic interneurons were observed in the basal ganglia of individuals with TS. Thus, we postulated that gamma-amino butyric acid (GABA)- and acetylcholine (ACh)-related genes might be associated with the pathophysiology of TS. Total RNA isolated from whole blood of 26 un-medicated TS subjects and 23 healthy controls (HC) was processed on Affymetrix Human Exon 1.0 ST arrays. Data were analyzed to identify genes whose expression correlated with tic severity in TS, and to identify genes differentially spliced in TS compared to HC subjects. Many genes (3627) correlated with tic severity in TS (p < 0.05) among which GABA- (p = 2.1 × 10⁻³) and ACh- (p = 4.25 × 10⁻⁸) related genes were significantly over-represented. Moreover, several GABA and ACh-related genes were predicted to be alternatively spliced in TS compared to HC including GABA receptors GABRA4 and GABRG1, the nicotinic ACh receptor CHRNA4 and cholinergic differentiation factor (CDF). This pilot study suggests that at least some of these GABA- and ACh-related genes observed in blood that correlate with tics or are alternatively spliced are involved in the pathophysiology of TS and tics.Brain research 03/2011; 1381:228-36. DOI:10.1016/j.brainres.2011.01.026 · 2.83 Impact Factor
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ABSTRACT: Tourette Syndrome (TS) is diagnosed based upon clinical criteria including motor and vocal tics. We hypothesized that differences in exon expression and splicing might be useful for pathophysiology and diagnosis. To demonstrate exon expression and alternatively spliced gene differences in blood of individuals with TS compared to healthy controls (HC), RNA was isolated from the blood of 26 un-medicated TS subjects and 23 HC. Each sample was run on Affymetrix Human Exon 1.0 ST (HuExon) arrays and on 3' biased U133 Plus 2.0 (HuU133) arrays. To investigate the differentially expressed exons and transcripts, analyses of covariance (ANCOVA) were performed, controlling for age, gender, and batch. Differential alternative splicing patterns between TS and HC were identified using analyses of variance (ANOVA) models in Partek. Three hundred and seventy-six exon probe sets were differentially expressed between TS and HC (raw P < 0.005, fold change >|1.2|) that separated TS and HC subjects using hierarchical clustering and Principal Components Analysis. The probe sets predicted TS compared to HC with a >90% sensitivity and specificity using a 10-fold cross-validation. Ninety genes (transcripts) had differential expression of a single exon (raw P < 0.005) and were predicted to be alternatively spliced (raw P < 0.05) in TS compared to HC. These preliminary findings might provide insight into the pathophysiology of TS and potentially provide prognostic and diagnostic biomarkers. However, the findings are tempered by the small sample size and multiple comparisons and require confirmation using PCR or deep RNA sequencing and a much larger patient population.American Journal of Medical Genetics Part B Neuropsychiatric Genetics 01/2011; 156B(1):72-8. DOI:10.1002/ajmg.b.31140 · 3.27 Impact Factor
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ABSTRACT: The cause of stroke remains unknown or cryptogenic in many patients. We sought to determine whether gene expression signatures in blood can distinguish between cardioembolic and large-vessel causes of stroke, and whether these profiles can predict stroke etiology in the cryptogenic group. A total of 194 samples from 76 acute ischemic stroke patients were analyzed. RNA was isolated from blood and run on Affymetrix U133 Plus2.0 microarrays. Genes that distinguish large-vessel from cardioembolic stroke were determined at 3, 5, and 24 hours following stroke onset. Predictors were evaluated using cross-validation and a separate set of patients with known stroke subtype. The cause of cryptogenic stroke was predicted based on a model developed from strokes of known cause and identified predictors. A 40-gene profile differentiated cardioembolic stroke from large-vessel stroke with >95% sensitivity and specificity. A separate 37-gene profile differentiated cardioembolic stroke due to atrial fibrillation from nonatrial fibrillation causes with >90% sensitivity and specificity. The identified genes elucidate differences in inflammation between stroke subtypes. When applied to patients with cryptogenic stroke, 17% are predicted to be large-vessel and 41% to be cardioembolic stroke. Of the cryptogenic strokes predicted to be cardioembolic, 27% were predicted to have atrial fibrillation. Gene expression signatures distinguish cardioembolic from large-vessel causes of ischemic stroke. These gene profiles may add valuable diagnostic information in the management of patients with stroke of unknown etiology though they need to be validated in future independent, large studies.Annals of Neurology 11/2010; 68(5):681-92. DOI:10.1002/ana.22187 · 11.91 Impact Factor
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University of California, Davis
Davis, California, United States
- Department of Neurology


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Is WR Denarius Moore Surviving The Cut A Good Thing For Oakland Raiders?
There's a lot truth to that old saying, "the definition of insanity is doing the same thing over and over again and expecting a different result." That is sort of the situation the Oakland Raiders find themselves in with WR Denarius Moore, who survived cutdown day yet again.
Coming into the season, Moore was one of the bigger enigmas – and problems – for head coach Dennis Allen and the Raiders. Taken in the fifth round (148th overall) by the Raiders in 2011, Oakland believed they'd unearthed a hidden gem, one that would be a difference-maker for their offense. Moore, entering his fourth season in Silver & Black, has failed to live up to any of the expectations the team had for him.
Though he's provided some flashes of brilliance, he has largely been a disappointment to the organization with his inconsistency and at times seeming disinterest.
While it's true that a quarterback situation in Oakland that was unsettled and inconsistent in its own right didn't make things easier on Moore or the other Raiders receivers, he didn't do himself or the team any favors either. Moore had a penchant for disappearing for long stretches, as well as for dropping very catchable balls. He was Oakland's version of Greg Little when he was with the Cleveland Browns: potential oozing from every pore, but plagued by an absolute lack of consistency and focus.
Over Moore's first three seasons in the league, he's caught 130 balls for 2,054 yards and has hauled in 17 touchdowns. But those are numbers that had the potential, like Moore, to be so much better. Coming into this year's training camp, there was a lot of speculation that Moore was on the roster bubble and might not even make the final 53-man squad.
But he's had a solid preseason, hauling in nine catches for 140 yards and two touchdowns. His best game of the exhibition schedule came just last week against the Seattle Seahawks, when he caught three passes for 58 yards and those two scores. Then again, this isn't the first time Moore has looked great during camp and the preseason only to disappear for weeks at a time during the regular season.
Speaking to Paul Gutierrez of ESPN.com, Allen said:
"One of the big topics has kind of been a little but of the inconsistency in the past, but I think he's been a lot better in this camp. I'm excited about Denarius Moore. I'm really excited about the whole receiving corps really, because I think we've got a lot of young guys that have an opportunity to surprise some people. But, I do think Denarius is getting better as a football player and he has in this camp."
It's something Raiders fans have heard many times before concerning Moore. He flashes that explosive home run potential, only to become the invisible man when the games really matter.
What should have Raiders fans even more concerned, however, is that unlike past years where Moore was the de facto No. 1 receiver, this year he is already behind James Jones and Rod Streater on the depth chart. Not only that, he'll be battling for playing time with Brice Butler, who has really had a breakout preseason and has earned some playing time, and Andre Holmes.
If Moore couldn't stay focused enough when he was the de facto No. 1, how can anybody possibly expect that he'll be more focused when he's the third, fourth, or even fifth option?
Moore has the potential to be an elite receiver in the NFL, but it's potential that he's failed to fulfill. He's looked just good enough to hang on to a roster spot, but can we reasonably expect that this will be the year Moore will suddenly blossom into the elite receiving talent the organization had hoped he'd be?
Allen and the Raiders coaching staff feel confident that this year will somehow be different. Many who've seen Moore play these last three years remain skeptical — but hopeful that he doesn't once again prove the truth in that definition of insanity.
Kevin Saito is a fiction writer, sports junkie, history nerd, and NFL contributor to RantSports.com Follow him on Twitter, Facebook, or on Google
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