text:
Taking calls & booking appointments
We are looking for an individual with good telephone manners. Taking in and outbound calls. Hours 12am-8pm Monday-Friday
- Permanent
We are looking for an individual with good telephone manners. Taking in and outbound calls. Hours 12am-8pm Monday-Friday
Our client is very successful organisation operating within the FMCG industry. An exciting opportunity has arisen for a PA and Business Assistant to join the team. The Role: * To enhance the effectiveness of General Manager as a support service.
A highly successful local independant estate agency seek a highly professional administrator with excellent customer facing skills to join their sales office. This is a part time position working 16 hours a week initially but it is essential that the
Join Our Team! We are a small, quirky accountancy firm, currently looking for the following person to join our team: Part Time Receptionist/Administrator 15 hours per week (mornings, hours negotiable) This is an important position as you will
Job Title: Technical Support Administrative Assistant Salary: GBP18,000 Based : Stonehouse, Gloucestershire Our Client is the leading independent medical equipment supplier to the UK and Ireland. The company has a 47-year track record in
Helen and Douglas House is a charity based in Oxford that provides hospice care to children and young adults, and their families. Our mission is to add quality, time and depth to shortened lives using the skills of our whole team. We provide a rang
My client, a leading national organisation is looking for a team of temporary workers to assist with administration work the company is undergoing. Main duties will include: *Dealing with customer enquiries *Processing invoices *Allocating paym
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*My client, a highly regarded learning provider are seeking to appoint a full time Operations Assistant who will be responsible for supporting the operations team in the general implementation of the school. They will assist in coordinating a team of
*My client, a highly regarded learning provider are seeking to appoint a full time Administrator for a new International Study Centre based in North Oxford. They will be responsible for engaging with both students and parents supporting the centre be
Job Title Administrative Assistant / Receptionist Job location Oxford We are a small-to-medium sized, growing biotech company that has developed a biomarker identification platform based on the latest scientific advances. We are opening a new l
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A small established I.T. firm based in Bath requires an experienced, motivated, I.T. literate, individual to perform general administration duties and provide marketing support for a new I.T. product. This is essentially a full time role however fl
Full Time Office Administrator We currently require a full time office administrator to run our Boiler Service Department, this positon would require running a small team of boiler engineers, booking appointments, annual service reminders, answer
The Legal PA's principal role is to provide fee earners with the support they need to perform the task of providing legal services to clients and help them maximise the amount of time they are able to spend on fee-earning and other essential non fee
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text:
Find an Internship or Volunteer in Attica, New York ( NY )
If you're looking for internships or volunteer work in Attica, New York or even to get a summer job, you've come to the right place! With over 30,000 around the county, chances are that GrooveJob.com has the right job for you and wants to be your only source for finding internships and volunteer positions in Attica, New York.
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|Browse by Employer (Click On Logos)
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Marketing Intern
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Buffalo, NY
|<< First < Previous 1 2 Next > Last >>

subset: commoncrawl


text:
Blomidon Inn
195 Main Street, Wolfville, Nova Scotia, B4P 1C3, Canada
Hotel Website 800-565-2291
#1 of 2 hotels in Wolfville
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- Blomidon Hotel Wolfville
Address: 195 Main Street, Wolfville, Nova Scotia, B4P 1C3, Canada
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Need advice about Wolfville, Canada? Visit the Travel Forum for Wolfville and ask our Answer Gurus.


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V.22 No.31 | 8/1/2013
Sound the Alarm: Willis Earl Beal still has juice
By Mark Lopez [ Fri Jul 26 2013 1:52 PM ]
Acousmatic Sorcery. For those who have cable, you might have seen him on "The X Factor."
But Beal is weird. His interviews boast a vagabond background mixed with rock star arrogance—because he doesn't bullshit. He knows who he is, and he truly doesn't care what anyone thinks, as long as he has room to make music at his own pace. Give the man some room so he can make magic happen. He recently shared a new track from his upcoming record Nobody knows. That song, titled "Too Dry to Cry," showcases his poignant and forthright lyrics as well as his soulful, ridiculously good vocals. Seriously, this dude has the ferocious authenticity of Robert Johnson with an affinity for slowly slithering into your eardrum like Otis Redding.
Comparisons aside, the guy is prolific. If you haven't seen his performance on "Later … with Jools Holland," watch it immediately. If it doesn't bring a minor tear to your eye, there's no humanity left in you; all that's left is a shell, a flicker of what used to be a vibrant example of humanity. Okay, I'm being a little dramatic, but it's that good. If his new track is anything to go by, we can expect some great things from his new record. Nobody knows. hits stores September 10. So keep an eye and ear out.
V.22 No.22 | 5/30/2013
Ross Halfin
"You are worthy."
By Samantha Anne Carrillo [ Fri May 31 2013 4:07 PM ]
Hearing the words referenced in the title of this blog from the legendary Alice Cooper may have done more for my self esteem than intensive psychotherapy ever could. See the Godfather of Shock Rock—along with some fellow named Marilyn Manson—in Burque this weekend, and read our uncut interview with the man, the myth, the "Cooper woman" in Infinitely More Mr. Nice Guy. Stream my favorite song from one of my favorite Alice Cooper albums, From the Inside, below. Isleta Amphitheater • Masters of Madness Tour • Alice Cooper • Marilyn Manson • Sat June 1 • 7 p.m. • $25-$112 • alicecooper.com
Ross Halfin
Show Up!
Infinitely More Mr. Nice Guy
Alice Cooper talks Hollywood Vampires, God, golf and Marilyn Manson
By Samantha Anne Carrillo
We're not worthy, but Alice Cooper graced us with some effervescent conversation anyway.
Today's Events
The Life, Blood and Rhythm of Randy Castillo [SOLD OUT] at KiMo Theatre
Documentary tells the story of the late, legendary drummer who played with Ozzy Osbourne, Mötley Crüe and more.
Educators Night: Only in Albuquerque at Albuquerque Museum of Art and History
Throw the Temple • Nomada • rock, alternative • Dead City Radio • Chris Ravin at Uptown Sports Bar & GrillMore Recommented Events ››
LowLife presents! • 4.8.2015
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- BiographyThis white male pornstar starred in 2 video scenes, having appeared for the first time in Butthole Pirates 5 in 2013. Alex has been favorited once by Gay Access members, and rated 4.5 out of 5 stars with 20 ratings. Some of the other people co-starring next to Alex are, most notably, Manxuel and Patrick. Alex's most often performed actions are Anal Sex, Cum on Chest, Handjobs, Blowjobs, and Hardcore. Video content with Alex was watched 16,677 times, with greater than 1 Gigabytes worth of exciting videos having been downloaded.
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NEW YORK (GenomeWeb) – A team led by researchers at Pacific Northwest National Laboratory has devised a Bayesian approach to proteoform modeling that could offer improved protein quantitation in large-scale proteomic experiments.
A trial upgrade to GenomeWeb Premium gives you full site access, interest-based email alerts, access to archives, and more. Never miss another important industry story.
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In Genome Research this week: methylation patterns in multiple myeloma, recent Y chromosome bottleneck, and more.
By studying the spectra of microbes on Earth, a team of researchers hopes to be better equipped to detect any on other worlds.
SolveBio's Mark Kaganovich says at TechCrunch that genomics needs an app to push it into the mainstream.
A University of Michigan team is using a Facebook app to recruit and keep in touch with participants in its 'Genes for Good' project.
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Denture Laboratory / Lab Technician
Aspen Dental is on a mission to give America a healthy mouth. By joining Aspen Dental you are not only making a statement that you are committed to providing quality care but you are also becoming a part of a collaborative network of dental professionals.
Candidates will ...
Mar 6 -
Cullman - Medical & healthcare
Aspen Dental is on a mission to give America a healthy mouth. For an estimated 47 million Americans, lack of access to affordable dental care is a real problem and by aligning with Aspen Dental you can be part of the solution.
This position directly contributes to the ...
Mar 6 -
Bessemer - Medical & healthcare
Supervisory Psychiatrist
This is an open & continuous vacancy announcement. This Supervisory Psychiatrist will report directly to the Chief, Mental Health and will serve on the Mental Health Executive Committee and other Committees, as assigned. The Supervisory Psychiatrist duties will include, ...
Feb 22 -
Birmingham - Medical & healthcare
Dental Assistant
The Dental Assistant supports the dentist during the examination and treatment of patients, and provides for the maintenance of accurate records, an orderly workplace and adequate inventories of materials.
Principal Duties and Responsibilities:
Relieves patients and ...
Feb 2 -
Talladega - Medical & healthcare
Account Executive Sales
Outside Sales Rep – Entry Level Sales – B2B Position
Have you ever thought that you would like to be in sales but you did not think you had the sales experience needed?
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We'll be sending text message alerts for your subscription to


text:
Dead Island 2 – Yager talk to us about injecting some life into the undead genre
179d ago - At this year's EGX [The Metropolist] were able to get an up front and personal look at the upcomi... | PS4
Koch Media acquires Fishlabs
480d ago - Fishlabs, Developer of Galaxy on Fire: Alliance, has been acquired by Koch Media. | Industry
Front-end Developers Wanted
Now - Want to help us build the new N4G platform? | Promoted post
Koch Media: When the Saints come marching in
590d ago - Dr. Klemens Kundratitz on the changes its THQ acquisitions are bringing to the company. | Industry
Saints Row and Metro films are a possibility with Koch Media
714d ago - "THQ's downfall may still be fresh in our minds, but several of its franchises, including Saints... | PC
DualShockers | Preview: Saints Row IV – The Type of Crazy we Need and Deserve
724d ago - Whenever a developer says they are ambitiously pushing the envelope with their next title (specif... | PC
Koch Media's CEO Confident That Saints Row and Metro Sequels Are Coming This Year
781d ago - "In news that will delight many, it looks like "The Next Great Sequel" – as Saints Row 4 has been... | PC
How Saints Row and Metro ended up with Koch Media
781d ago - Gamasutra- Of all the results of THQ's recent auction, perhaps the most unexpected was Germany's... | PC
Saints Row deal "excellent value for money", says Koch Media boss
782d ago - EDGE - New owner of Saints Row IP to respect Volition's creative freedom as work continues on thi... | Industry
Koch Media: "We are not ambitious to be the next THQ"
783d ago - GI - CEO Klemens Kundratitz on THQ's collapse, the acquisition of Saints Row, and the problem wit... | Culture
Koch Media Invest in Free-to-Play via Infernum Productions
828d ago - Koch Media, in conjunction with the publishing label Deep Silver, has announced – in the interest... | PC
Kylie Sing & Dance to hit in time for christmas
899d ago - Have you ever dreamt about being like Kylie, if so now is your chance as the Pop sensation gets h... | Wii
Koch Media Partners with Rubicon Organization
1031d ago - GamingShogun.com writes, "The 50/50 joint venture with Koch Media provides global reach, particul... | Industry
Jane's Advanced Strike Fighters (JASF) - 4 New Aircraft Revealed
1122d ago - Koch Media today revealed four more aircrafts of the upcoming action flight simulation Jane's Adv... | PC
NCsoft Sign Distribution Agreement with Koch Media
1304d ago - NCsoft has announced an extension of its partnership with distributor Koch Media to include the U... | PC
Deep Silver to Publish Cartoon Network Punch Time Explosion in EU
1333d ago - "Deep Silver, the games label of Koch Media, a leading producer and distributor of digital entert... | 3DS
Jane's Advanced Strike Fighters details announced
1334d ago - Koch Media and Evolved games announced details and release screenshots for the upcomming PS3,Xbox... | PC
Ronnie O'Sullivan is the face of World Snooker Championship Real 2011
1527d ago - Koch Media, new snooker title will feature Ronnie O'Sullivan as the face of World Snooker Champio... | PC
Koch Media Sign Publishing Agreement with bitCOMPOSER Games
1531d ago - Koch Media has announced that it is the UK distributor for two of German publisher bitComposer Ga... | PC
18 stories found


text:
Country Inns & Suites By Carlson
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
- Continental Breakfast
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- Wireless internet connection in room (free)
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TripAdvisor Reviews Country Inns & Suites By Carlson Merrillville
Travel Blogs from Merrillville
Day 19
... Pier to book out 'architectural' cruise. When got to the ticket office we found that it was fully booked until late afternoon so we chose the harbour tour instead. After exploring Navy pier whilst waiting for the cruise, we queued up for our boat only to be told there had been maintenance problems since we'd booked our tickets and that boat wouldn't be leaving until late afternoon as well! So they offered us an up grade to the extreme thrill ride (i should mention the boats were ...
We slept in a bit and started the day with a full breakfast. We hopped on bus 6 to the Science and Industry Museum in Hyde Park. We are museum lovers and this museum is worth loving! We started our visit in the Disney Archive Exhibit. It featured his office, the story of his beginnings, storyboards for a number of cartoons, the real books from Cinderella and Sleeping Beauty that start the movie, an area where they teach you ...
First Ever Entry
... we have added another gym to our repertoire. If a city has a gym used for volleyball, we have probably been there at some point. Anyhow, our trip started on Friday. Mom, Erin, Aunt Kerry, Erin's teammate Jayla, and I loaded into the car and took off around 8:30. Around Ann Arbor, Aunt Kerry got a call that her car wasn't ready to be picked up yet. Sooooo, we ended up dropping her off at Starbucks to find a ride back home. ...
3 nts in Chicago
... but way over the top!
Saturday - snowing heavily so we decided to take the trolley bus tour to get an orientation of the city without freezing. Had a fantastic driver who was most informative. Route took us from opposite our hotel on Water Tower Place past the Hancock Tower, Lakeshore, Oak Beach, through River North area, Willis tower, State Street, Chicago Theatre, Museum Campus, Millenium Park, Navy Pier ...
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39.3K Plays / 182 Likes / 18 Comments
Eric Reinstra's new video! We sent Eric down to Brazil with our all new Darko and the Legendary Fuel to see what he could come up with. Here is the answer! Feel The Power!+ More details
48.9K Plays / 70 Likes / 8 Comments
http://ride.slingshotsports.com/2013-RPM We changed everything with the introduction of the RPM five short years ago. It's proven "Open-C" canopy design and Slingshot's…+ More details
Azul - A Waterlust film about women in water03:31
A short film by Paula Marinkovic & Alexandra Menk that explores their aquatic lifestyle. Shot entirely on GoPro cameras with the Blurfix lens by Snake River Prototyping. Powered by Adventure…+ More details
Lift - A Waterlust Film about Hydrofoils03:08
A short film by Patrick Rynne showing some of the coolest wind-powered foiling craft in action. Shot entirely on GoPro Hero 2 Cameras. Powered by Adventure Sports Miami and Outer Banks Kiting.+ More details
106K Plays / 683 Likes / 21 Comments
LTD gets on a plane and explores around Indonesia to find surf, wind, pretty girls, awesome food, and a laid back good time. This is from our first stop in LTD's island hopping exploits. Its…+ More details
5,185 Plays / 14 Likes / 1 Comment
After some fierce internet debate, here's a neatly RE-cut and inspiring comparison between Laird Hamilton's "Millennium Wave" in 2000 and Bruce Irons' "Boardies Tearer"…+ More details
203K Plays / 1,742 Likes / 64 Comments
An introduction to the phenomenal sport of Kiteboarding. Music: Intro by The XX www.paiwenboards.com+ More details
killedthewind - WALK ABOVE WATER04:59
57.9K Plays / 268 Likes / 38 Comments
killedthewind's up-close-and-personal view of what it feels like to ride above the ocean (for those who don't know). For those that do know, this is a film of progressive strapless surfing,…+ More details
58.7K Plays / 255 Likes / 19 Comments
Ben Wilson's new movie - "Shades of Green" The movie features Ben Wilson, Reo Stevens, Ian Alldredge and Bear Karry in Indonesia doing what they do - surfing and kiting. The…+ More details
There are 9 videos in this album. Albums make it easy to organize a collection of videos. They can be used to display videos together, or sent to friends as a playlist. You can even arrange the order of videos in each album.
You can add a video to one of your albums or create a new album from the "+Add to…" tab on video pages.
Albums can also be used to show videos on other web sites using Vimeo Widgets.


text:
Main News Page
Thursday, August 16, 2012
More items for
Program/Project Management
The U.S. Air Force Global Strike Command is inviting bids for applying coatings to two hangar floors at Whiteman Air Force Base in Missouri—a surface area of more than 33,000 square feet and a contract estimated at up to $250,000.
The project consists of applying an epoxy-urethane coating system to concrete flooring in two existing aircraft hangars: one, about 20,190 square feet; the other, 13,360 square feet. A site visit is scheduled for Sept. 5. Bids will be opened Sept. 13.
U.S. Air Force photo/Senior Airman Jessica Snow
The work involves providing all personnel, supervision, transportation, material, tools, disposal, and surface preparation necessary to prepare the existing concrete flooring and install the new epoxy floor coating as defined in the Statement of Work.
The contract value is estimated at between $100,000 and $250,000.
About Whiteman AFB
Activated on Aug. 6, 1942, as Sedalia Glider Base, the base is now the home of the 509th Bomb Wing, which operates and maintains the Air Force's premier weapon system, the B-2 bomber.
The base was renamed in 1955 to honor 2nd Lt. George Whiteman, who was one of the first airmen killed defending Pearl Harbor in the attack Dec. 7, 1941.
Whiteman AFB is home of the B-2 Spirit and also host of the 442nd Fighter WIng, the Army National Guard's 1/135th Aviation Battalion, and the Navy Reserve's Mobile Inshore Undersea Warfare Unit 114.
Reported by Paint BidTracker, a construction reporting service devoted to identifying contracting opportunities for the coatings community. Visit us on Facebook!
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Actually, they don't
It's a mistake to think all neocons have the same appreciation for Israel. They don't.
Some are motivated by religious or spiritual interests.
WSome are moved by profit from technology that is purchased through military contracts.
Some are interested in the secualr possibilies that come from a society established in the art of self defense.
Some have been to Israel many times and others like me have yet to go, but definately lookm forward to when I go and it is on the top of my list of things to do.. though it appears it won't be untikl 2015.
We didn't "enable" Israel to exist. Zionists.. people who for all the above reasons, after WWI, began investing in Israel. Investors continue to see intellectual gold being produced in Israel, so we continue to invest; However, the world has changed in many ways.. now we are dealing with a UN Agenda, and Israel is at ground Zero, because Israel's first war was independence of the UN, so Israel's treaties and agreements are very different than everyone who is signed up with the UN and have no choice about the Agenda. That's why so many people watch Israel, though propeganda has people looking at the Palestinian conflict, which is created as a decoy. Look at Palestine and not this technology advancing humanity. We can't have Israel advancing humanity when the UN is busy watching the world go to Hell. Why be inspired when you can wax apathetic?
Seems a bunch of people from Huffington Post and The Nation have come to DP to cener, abolish, kill, those who they don't agree with. I don't agree with you or your censorship, how you stand for women being second class citizens, child rape in the name of marriage, executing homosexuals, disfiguring and raping women, or your communist agenda, which you don't even realize you support because you are so brainwashed.
- Login to post comments


text:
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Butterfly Beauté specializes in crafting organic shampoos and conditioners for women with curly, wavy, and kinky hair. Their products are made with natural ingredients, and are designed to promote healthy hair and skin.


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HPC Market Watch
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Towerstream to Report Fourth Quarter and Year End 2014 Financial Results on March 12, 2015
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text:
Page 1
Human Male Infertility Caused by Mutations
in the CATSPER1 Channel Protein
Matthew R. Avenarius,1,5Michael S. Hildebrand,2,5Yuzhou Zhang,2Nicole C. Meyer,2
Luke L.H. Smith,2Kimia Kahrizi,4Hossein Najmabadi,4and Richard J.H. Smith2,3,*
Male infertility, a common barrier that prevents successful conception, is a reproductive difficulty affecting 15% of couples. Heritable
forms of nonsyndromic male infertility can arise from single-gene defects as well as chromosomal abnormalities. Although no CATSPER
gene has been identified as causative for human male infertility, male mice deficient for members of the CatSper gene family are infertile.
In this study, we used routine semen analysis to identify two consanguineous Iranian families segregating autosomal-recessive male
infertility. Autozygosity by descent was demonstrated in both families for a ~11 cM region on chromosome 11q13.1, flanked by markers
D11S1765 and D11S4139. This region contains the human CATSPER1 gene. Denaturing high-performance liquid chromatography
(DHPLC) and bidirectional sequence analysis of CATSPER1 in affected family members revealed two separate insertion mutations
(c.539-540insT and c.948-949insATGGC) that are predicted to lead to frameshifts and premature stop codons (p.Lys180LysfsX8 and
p.Asp317MetfsX18). CATSPER1 is one of four members of the sperm-specific CATSPER voltage-gated calcium channel family known
to be essential for normal male fertility in mice. These results suggest that CATSPER1 is also essential for normal male fertility in humans.
In approximately half of the 15% of couples who cannot
conceive, the cause is ascribed to male infertility.1,2The
underlying pathogenetic mechanisms can reflect the effect
of environmental toxins, such as pesticides, glycol ethers,
and heavy metals; systemic disorders, like hypothalamic-
pituitary disease, testicular cancers, and germ cell aplasia;
and genetic factors, including aneuploidies and single-gene
Of the aneuploidies associated with male infertility, the
classic example is Klinefelter's syndrome.4,5The presence
of an extra X chromosome in these 47, XXY males leads
to destruction of the seminiferous epithelium and azoo-
spermia (absence of sperm). Single-gene defects associated
with azoospermia and asthenozoospermia (abnormal
sperm motility) include mutations in the cyclic-dependent
protein kinases AKAP3 (MIM 604689) and AKAP4 (MIM
300185). In both humans and mice, deletions in these
two genes cause sperm immotility secondary to dysplasia
of the fibrous sheath surrounding the axoneme.6–8Muta-
tions in the dynein genes that encode proteins of the
axonemal dynein cluster (DNAH1 [MIM 603332], DNAH5
[MIM 603335], and DNAH11 [MIM 603339]) have been
identified in persons with Kartagener's syndrome (MIM
244400) and also cause asthenozoospermia.9,10
Two four-generation consanguineous Iranian families
segregating nonsyndromic autosomal-recessive male infer-
tility were the subject of this study. In consenting persons,
10 ml of whole blood was obtained as a source of genomic
DNA. Human Research Institutional Review Boards at the
Welfare Science and Rehabilitation University and the
Iran University of Medical Sciences, Tehran, Iran and at
the University of Iowa, Iowa City, USA approved all proce-
dures. In both families, affected males of first-cousin
marriages who were themselves married and undergoing
L-1025, IV:2 and IV:4; Family L-968, IV:4) (Figure 1). Clin-
ical analysis of semen from individuals IV:2 (L-1025) and
IV:4 (L-968) showed sperm defects and reduced fertility
(Table 1). This routine analysis included measurement of
volume, pH, sperm count, sperm motility and sperm form
(structure). Although the pH of the semen from both indi-
viduals was in the normal range, examination of all other
parameters revealed abnormalities (Table 1). Both affected
males demonstrated nonmotile sperm or sperm motility
below the normal threshold, low sperm count, increased
abnormally structured spermatozoa, and reduced semen
Because neither family alone was sufficiently large to
allow for generation of a LOD score > 3.0, short tandem
repeat polymorphisms (STRPs) flanking the four CATSPER
genes were screened for allelic homozygosity with the use
of previously reported PCR conditions.11The CATSPER
genes were selected as candidates because their deficiency
had previously been linked to male infertility in mice.12,13
Regions of homozygosity were expanded with the use of
additional STRPs and single-nucleotide polymorphisms
(SNPs), showing that affected males in both families
demonstrated autozygosity by descent over a common
interval, located on chromosome 11, that spans ~11 cM
and includes the testis-specific CATSPER1 gene (MIM
606389) (Figure 1). The combined LOD score at this locus,
with the use of only males from these two families, was
ally related to the infertility in these men. Regions of
1Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109-0618, USA;2Department of Otolaryngology, Head and
Neck Surgery,3Interdisciplinary Ph.D. Program in Genetics, University of Iowa, Iowa City, IA 52242, USA;4Genetics Research Center, University of Social
Welfare and Rehabilitation Sciences, Evin, Tehran 19834, Iran
5These authors contributed equally to this work
*Correspondence: email@example.com
DOI 10.1016/j.ajhg.2009.03.004. ª2009 by The American Society of Human Genetics. All rights reserved.
The American Journal of Human Genetics 84, 505–510, April 10, 2009
Page 2
autozygosity by descent were not present at the other three
CATSPER loci (data not shown).
Genomic DNA from persons in both families was ampli-
fied, and all 12 coding exons and splice sites of CATPSER1
matography (DHPLC) and bidirectional sequencing with
the use of gene-specific primers and previously reported
conditions (Table S1, available online).11Both methods
independently confirmed the presence of sequence varia-
tions; the specific mutations at the nucleotide level were
resolved by bidirectional sequencing. Sequence chromato-
grams were compared to the human CATSPER1 cDNA
sequence (uc001ogt.1; NM_053054).
In family L-1025, an insertion mutation (c.539-540insT)
that segregated in homozygous fashion in the two infertile
males IV:2 and IV:4 was identified in exon 1 (Figure 2A).
The insertion of the single thymine nucleotide is predicted
to disrupt the open reading frame (ORF) of CATSPER1 and
introduce eight new amino acids followed by a premature
stop codon (p.Lys180LysfsX8). If the aberrant transcript is
not subject to nonsense-mediated decay (NMD), a severely
truncated 188 aa protein will be translated (Figure 3A).
In family L-968, a second insertion mutation (c.948-
949insATGGC) was discovered in exon 1 (Figure 2B). This
mutation introduces five nucleotides into the CATSPER1
ORF and is homozygous in one affected male (IV:4) and
one female (IV:2) family member. The frameshift caused
by this insertion is predicted to substitute the D317 residue
for a methionine and introduce 18 new residues before a
premature stop codon (p.Asp317MetfsX18). In the absence
of NMD, the predicted product would be a truncated 335
residue protein (Figure 3B). For exclusion of the possibility
Figure 1.
Genotyping of STRPs and a SNP on chromosome 11 in (A) family L-1025 and (B) family L-968. The region of autozygosity by descent,
which includes CATSPER1, is boxed.
Linkage Mapping of an Infertility Locus Shared by Two Iranian Families
Table 1.
Semen Analysis of an Affected Male from Each
TestIV:2 (L-1025)IV:4 (L-968)Normal Range
Volume (mL)
Sperm count (million)
Motility (% motile)
Form (% normal)
The American Journal of Human Genetics 84, 505–510, April 10, 2009
Page 3
that the two insertion mutations identified in these fami-
lies are polymorphisms, 576 Iranian control individuals
(1152 chromosomes) were screened. All control individ-
uals were negative for both of these mutations.
The CATSPER1 proteinbelongs toa family of four sperm-
specific tetrameric voltage-gated cation channels (CATS-
PER1,2,3,4) that are highly conserved in humans and
mice.13,14CATSPER proteins consist of a single, six-trans-
membrane-spanning repeat with a P loop between trans-
membrane domains S5 and S6 that shows homology
to four-repeat calcium (Cav) channels.13The mutant
CATSPER1proteins predicted
(p.Lys180LysfsX8) and L-968 (p.Asp317MetfsX18) lack all
six transmembrane domains and the P loop. Thus, even
if a truncated protein is made, CATSPER1 channel activity
would be abolished in homozygous carriers of either of
these mutations. It is important to note that these effects
have been predicted on the basis of the identified DNA
alterations at the genomic level and that additional studies
are required for confirmation of these effects at the tran-
scriptional or translational level.
The expression of CatSper1 is restricted to the plasma
membrane of spermatozoa above the fibrous sheath in
the principal piece of the sperm tail (Figure 4A).13Its func-
forfamilies L-1025
tionality was confirmed by Carlson and colleagues and Ren
and colleagues in experiments that demonstrated the
requirement of CatSper1 for Ca2þentry into the flagellum
and for Ca2þ-mediated hyperactivated sperm motility.13,15
Once sperm enter the female reproductive tract, they
become hyperactive, in a process termed ''capacitation''
that involves three Ca2þ-mediated events: initial activa-
tion, hyperactivation of motility, and engagement of
a protein kinase cascade.15Hyperactivated motility occurs
at the site of fertilization to facilitate penetration into the
asymmetric waveform. Absence of CatSper1 impairs this
phase of motility.15
Definitive evidence that CatSper1 functions as a voltage-
gated calcium channel to facilitate hyperactivated sperm
motility came from whole-cell patch-clamp measurements
of spermatozoa.16CatSper1 channel currents were potenti-
ated in response to intracellular alkalinization, increasing
the concentration of intraflagellar calcium and thereby
inducing hyperactivity. Although those studies were
between mouse and human suggests that a similar mecha-
nism might be responsible for the infertility in the males
that we report in this study.
Figure 2.
Insertion mutations were identified in exon 1 of CATSPER1 in both families.
(A) Family L-1025 segregates a c.539-540insT mutation, family L-968 a c.948-949insATGGC mutation. Sequences were aligned to the
human CATSPER1 cDNA sequence (uc001ogt.1; NM_053054). The forward DNA strand and CATSPER1 genotypes for screened family
members are shown.
Genetic Analyses of Affected Family Members Reveals CATSPER1 Mutations Segregating with Infertility
The American Journal of Human Genetics 84, 505–510, April 10, 2009
Page 4
Clinical evaluation of fertility in males is commonly
for abnormalities of sperm number, morphology, and
motility, as well as for indicators of the function of the
genital tract, including semen volume and pH.17These
measures are relatively rudimentary, and although semen
analysis is effective for determination of azoospermia,
changes in sperm morphology and motility can be missed.
Despite the fact that a significant number of gene products
have now been associated with infertility in men (reviewed
in8), many of these etiologies may go undiagnosed in
the absence of a more rigorous clinical examination that
includes measurement of sperm-motility parameters, such
parameters were all markedly impaired in CatSper1?/?
mouse sperm as compared to wild-type sperm. CatSper1?/?
sperm were also sluggish, displayed less directed move-
ment, and lacked vigorous beating and bending in the tail
region.13Unfortunately, because of technological limita-
tions, we were unable to examine these parameters in the
sperm of the Iranian male family members described here.
In this study, we have described a rare example of
Mendelian inheritance of nonsyndromic male infertility.
The rarity of similar reports might reflect difficulties in
diagnosing and characterizing male infertility. The inser-
tion mutations that we identified in CATSPER1 suggest
that mutations in the CATSPER family of calcium channel
subunits should be considered candidate genes in cases of
male infertility. As a corollary, our findings also suggest
that therapeutic strategies designed to block CATSPER1
activity could be useful as a male contraceptive.18
Supplemental Data
Supplemental Data include one table and can be found with this
article online at http://www.ajhg.org/.
The authors sincerely thank the families for their participation in
this study. R.J.H.S. is the Sterba Hearing Research Professor,
University of Iowa College of Medicine. M.S.H. is supported by
an Australian National Health and Medical Research (NHMRC)
Overseas Biomedical Fellowship.
Received: February 17, 2009
Revised: March 3, 2009
Accepted: March 9, 2009
Published online: April 2, 2009
Figure 3.
The predicted alterations of CATSPER1 are severely truncated proteins if the transcripts are not subject to NMD ([A] family L-1025,
[B] family L-968). Forward and reverse DNA strands, as well as the corresponding amino acid sequence, are shown.
Predicted Effect of the Mutations on the CATSPER1 Protein
The American Journal of Human Genetics 84, 505–510, April 10, 2009
Page 5
Web Resources
The URLs for data presented herein are as follows:
Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.
UCSC Genome Browser, http://genome.ucsc.edu/
1. Templeton, A., Fraser, C., and Thompson, B. (1990). The
epidemiology of infertility in Aberdeen. BMJ 301, 148–152.
2. Mosher, W., and Pratt, W. (1990). Fecundity and Infertility in
the United States, 1965–1988. Advanced Data from Vital and
Health Statistics (Hyattsville: National Center for Health
3. Skakkebaek, N.E., Giwercman, A., and de Kretser, D. (1994).
Pathogenesis and management of male infertility. Lancet
343, 1473–1479.
4. Arce, B., and Padron, S. (1980). Spermatogenesis in Klinefel-
ter's syndrome. Reproduccion 4, 177–184.
5. Grabski, J., Pusch, H., Schirren, C., Passarge, E., Held, K.,
Bartsch, W., and Wernicke, I. (1979). Andrologia 11, 182–196.
6. Turner, R.M., Musse, M.P., Mandal, A., Klotz, K., Jayes, F.C.,
Herr, J.C., Gerton, G.L., Moss, S.B., and Chemes, H.E. (2001).
Molecular geneticanalysisof twohumanspermfibroussheath
proteins, AKAP4 and AKAP3, in men with dysplasia of the
fibrous sheath. J. Androl. 22, 302–315.
7. Chemes, H.E., Brugo, S., Zanchetti, F., Carrere, C., and
Lavieri, J.C. (1987). Dysplasia of the fibrous sheath: An
ultrastructural defect of human spermatozoa associated
with sperm immotility and primary sterility. Fertil. Steril.
48, 664–669.
8. Matzuk, M.M., and Lamb, D.J. (2008). The biology of infer-
tility: Research advances and clinical challenges. Nat. Med.
14, 1197–1213, Epub 2008 Nov 6.
9. Zuccarello, D., Ferlin, A., Cazzadore, C., Pepe, A., Garolla, A.,
Moretti, A., Cordeschi, G., Francavilla, S., and Foresta, C.
(2008). Mutations in dynein genes in patients affected by
isolated non-syndromic asthenozoospermia. Hum. Reprod.
23, 1957–1962, Epub 2008 May 20.
10. Schwabe,G.C.,Hoffmann,K.,Loges,N.T.,Birker,D.,Rossier,C.,
de Santi, M.M., Olbrich, H., Fliegauf, M., Failly, M., Liebers, U.,
et al. (2008). Primary ciliary dyskinesia associated with normal
Mutat. 29, 289–298.
11. Prasad,S.,Kolln,K.A.,Cucci,R.A.,Trembath,R.C.,VanCamp,G.,
screening of SLC26A4 by denaturing high-performance liquid
chromatography and the identification of eleven novel muta-
tions. Am. J. Med. Genet. A. 124A, 1–9.
12. Qi,H.,Moran,M.M.,Navarro,B., Chong,J.A.,Krapivinsky, G.,
Krapivinsky, L., Kirichok, Y., Ramsey, I.S., Quill, T.A., and
Clapham, D.E. (2007). All four CatSper ion channel proteins
are required for male fertility and sperm cell hyperactivated
motility. Proc. Natl. Acad. Sci. USA 104, 1219–1223, Epub
2007 Jan 16.
13. Ren, D., Navarro, B., Perez, G., Jackson, A.C., Hsu, S., Shi, Q.,
Tilly, J.L., and Clapham, D.E. (2001). A sperm ion channel
Figure 4.
Murine studies have shown that CatSper1 is essential for normal capacitation and fertilization.
(A) CatSper1 expression in the mouse sperm tail.
(B) CatSper1 null sperm cannot penetrate the zona pellucida to fertilize the oocyte.
The Role of CatSper1 in Capacitation and Fertilization
The American Journal of Human Genetics 84, 505–510, April 10, 2009
Page 6
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14. Lobley, A., Pierron, V., Reynolds, L., Allen, L., and Michalo-
vich, D. (2003). Identification of human and mouse CatSper3
and CatSper4 genes: Characterisation of a common interac-
tion domain and evidence for expression in testis. Reprod.
Biol. Endocrinol. 1, 53.
15. Carlson,A.E.,Westenbroek,
Clapham, D.E., Hille, B., Garbers, D.L., and Babcock, D.F.
(2003). CatSper1 required for evoked Ca2þ entry and control
of flagellar function in sperm. Proc. Natl. Acad. Sci. USA 100,
14864–14868, Epub 2003 Dec 1.
R.E., Quill,T.,Ren, D.,
16. Kirichok, Y., Navarro, B., and Clapham, D.E. (2006). Whole-
line-activated Ca2þ channel. Nature 439, 737–740.
17. WHO. (1999). World Health Organization Laboratory Manual
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Mucus Interaction (Cambridge: Cambridge University Press).
18. Li, H., Ding, X., Guan, H., and Xiong, C. (2008). Inhibition of
human sperm function and mouse fertilization in vitro by an
antibody against cation channel of sperm 1: The contracep-
tive potential of its transmembrane domains and pore region.
Fertil. Steril., in press. Published online October 31, 2008.
The American Journal of Human Genetics 84, 505–510, April 10, 2009


text:
|Even Out West, the Masajid Are Expanding
|Community News - Community News
|Written by Hena Zuberi, Muslim Link Staff Reporter
|Wednesday, 07 May 2014 22:11
Hagerstown Community Breaks Ground for 5,000 SF Building
The community in Hagerstown, MD broke ground on the expansion of the 100 year old stone structure that houses their masjid. Dr. Abdul Waheed, a resident of the area since the early 1980s, says that it is a project ten years in the making. Less than 5 minutes off Interstate 70 Exit 32 B brings travelers to the Islamic Society of Western Maryland.
The site was purchased by the community in 1991. The community has evolved from the 6 families of doctors, who moved to Hagerstown to find a safe haven from big city life, to more than 200 families. Over the years, Bosnian refugees and South Asian, Arab, African immigrants have made Hagerstown their home. Muslim families from bordering states, West Virginia and Pennsylvania, also call the masjid their spiritual home.
Funding had held up the project, but the community has now raised the money from within and the ground is being prepared for construction. The contract signed for $1.1 million is just shy of the final amount.
The expansion will house a 5000 sq. ft. hall that will double as additional prayer space during jummah and the Eidain. A foldable divider will separate the multi purpose room from the current prayer space. A foyer for the women, a new kitchen, bathrooms for men and women will also be a part of the extension. "Many community members put in their thoughts, their expertise [and money]," said Dr Waheed.
The community has an active youth group, and hifdh program that has graduated 4 huffadh.
The ground-breaking ceremony was attended by the Board of trustees and Board of Directors, community members as well as leadership from Dar us Salaam in College Park, Maryland.
The community prays that the project will be completed by next spring.
Representatives of the board expressed their appreciation for the local authorities who have been 'very helpful and cooperative."
The Islamic Society of Western Maryland is located at 2036 Day Rd Hagerstown, MD 21740 and online at www.iswmd.org.
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1/3rd Residence Guesthouse Yashiki Accommodation & Rooms
Located in Tokyo (Akihabara), 1/3rd Residence Guesthouse Yashiki is close to Akihabara Electric Town, Sensoji Temple, and Tokyo Imperial Palace. Also nearby are Ueno Park and Tokyo National Science Museum.
Property Features.
Complimentary wireless and wired high-speed Internet access is available in public areas. This is a smoke-free property. A total renovation of this property was completed in December 2014.
The 12 guestrooms at 1/3rd Residence Guesthouse Yashiki include air conditioning. Bathrooms offer showers and hair dryers.
A bit difficult to locate the place especially if you are arriving in the night but…
Pro. : the staff told me everything that I must do and must not , it was clear. : fast…
Enter dates to check prices
Hotel Info: 800 1205131from S$111
- Japanese Style 2 Bed Room Apartment
- Japanese Style Studio Apartment
- Japanese Style - Private Triple Room (Min 2 Nights)
- Japanese Style - Private Triple Room
- Japanese Style 2 Bed Room Apartment (Min 2 Nights)
- Japanese Style 2 Bed Room Apartment (Min 2 Nights)
- Modern Japanese Style Tatami Single Room
- Japanese Style - Private Triple Room - Machi (Min 2 Nights)
- JapaneseStyle - Private Single Room
- Roof Top - Family Room with Balcony
- Japanese Style - Private Quad Room - Kaze (Min 2 Nights)
- Roof Top - Triple Private Room
- Japanese Style Studio Apartment (Min 2 Nights)
- JapaneseStyle - Private Single Room (Min 2 Nights)
- Japanese Style - Private Quad Room - Kaze
- Roof Top - Family Room with Balcony (Min 2 Nights)
- Modern Japanese Tatami Twin Room
- Roof Top - Triple Private Room (Min 2 Nights)
- Japanese Style - Private Triple Room - Machi
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At a glance
Key facts
Hotel size
- This hotel has 12 rooms
- This hotel is arranged over 5 floors
- Check-in time 3 PM-9 PM
- Check-out time is 10 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- No cribs (infant beds)
- No pets or service animals allowed
- Free WiFi and wired Internet access in public areas
- No parking
Other information
- Smoke-free property
Nearby Two Star Tokyo hotels
In the hotel
- Luggage storage
- Number of buildings/towers - 2
In the room
- Air conditioning
- Individually furnished
- Shower only
- Hair dryer
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1/3rd Residence Guesthouse Yashiki Accommodation & Rooms's small print
The Japanese Ministry of Health, Labour, and Welfare requires all international visitors to submit their passport number and nationality when registering at any lodging facility (inns, hotels, motels, etc. ). Additionally, lodging proprietors are required to photocopy passports for all registering guests and keep the photocopy on file.
This property does not have elevators.
Optional extras
Rollaway beds are available for JPY 2100 per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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Award reflects company's consistently high level of customer service.
Redmond, Wash. — Cascade Pest Control has been awarded the prestigious 2010 Angie's List Super Service Award, an honor bestowed annually on approximately 5 percent of all the companies rated on the nation's leading provider of consumer reviews on local service companies.
"Our Super Service Award winners are the cream of the crop when it comes to providing consistently high quality customer service, as judged by the customers who hired them," said Angie Hicks, founder of Angie's List.
"We are proud and delighted to be recognized by our customers for our commitment to providing top quality service," said Diana Sheridan, co-founder of Cascade Pest Control. Cascade Pest also earned the award in 2007 and 2008. The company has been protecting property and health since 1979, and provides pest control service all over King and Snohomish counties.
Angie's List Super Service Award winners have met strict eligibility requirements including earning a minimum number of reports, an exemplary rating from their customers and abiding by Angie's List operational guidelines.
Service company ratings are updated daily on Angie's List, but members can find the 2010 Super Service Award logo next to company names in search results on AngiesList.com.
Two of the most destructive termite species in the world -- responsible for much of the $40 billion in economic loss caused by termites annually -- are now swarming simultaneously in South Florida, creating hybrid colonies that grow quickly and have the potential to migrate to other states.
Casey Parker recently won the ONE WORLD competition, organized by the UF College of Agricultural and Life Sciences Challenge 2050 Project in conjunction with the Syngenta Good Growth Plan.
During its meeting in Washington, D.C., on March 14, the National Pest Management Association's (NPMA) Board of Directors approved the organization's Pollinator Best Management Practices (BMPs).
Featuring a "Who's Who" of speakers with decades of experience serving the commercial pest management segment, the April 29 virtual event is filled with information you need to know to expand your presence in this dynamic marketplace. Cost is only $99 and attendees will receive full access to all of the educational sessions and a complimentary copy of the highly-acclaimed PCT Guide to Commercial Pest Management, a $29.95 value!
PMPs can put EcoRaider to the test in their own field applications.


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U of M spins off record number of startups in 2013
- Katharine Grayson
- Staff reporter- Minneapolis / St. Paul Business Journal
- Email | Twitter | Google+
Research at the University of Minnesota spawned 14 startups in fiscal 2013, a record for the school's Office for Technology Commercialization.
Companies launched by the school include EmboMedics, which has developed a polymer bead that cuts off blood supply to cancerous tumors; Andas, which makes a smartphone breathalyzer; and health IT venture Evidentia Health.
Click here to see a full list of the companies
The University said in a press release Friday it expects to launch five more companies in the coming months.
Last year, the U of M spun out a dozen companies, a record at the time.
To see a cool graphic displaying technologies in the U's pipeline, check out the bottom of this page.
Katharine Grayson covers med tech, clean tech, technology, health care and venture capital.
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See how to make a chilled down version of the toasted almond cocktail.
In this video, you'll see how to make a cooled down version of the toasted almond cocktail. This creamy milkshake is given a healthy shot of amaretto and coffee liqueur, then topped with whipped cream and toasted almonds. Watch the video, then get the recipe for Frosted Almond. Want even more? See more cocktail videos >>
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Bunny cakes, lamb cakes, chocolate eggs, and carrot cakes to nibble on.
Breakfast casseroles, drinks, fancy eggs, and brunch ideas for a sweet Easter event.
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