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Do you consent to the way you are governed???? Only 22% of Americans say the government operates with our consent.
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s. d. butler
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You pompous arrogant little assholes, I don't know what horse you all rode in on, or where you get off thinking you have any god given right to tell us all how to live, but you don't! You are nothing, you have no power, the only power you think you have is imaginary, made up, a fiction, and a tissue of corrupt lies wrapped up in a veil of "LAWS" written on little pieces of paper! That's all you are a thin illusion of lies, words written on paper as if to magically give you some authority, power, and money! You possess none. Your power is an illusion, it is based off of the biggest occult lie ever told. You have minions of followers who worship at your alters as you hide in your temples, and worship you as false gods. You feel that if you write it on paper and pass it around for others to sign, that it has some magically binding power of us all, and that you have the ability to murder, rob, and enslave us because of your conjured up lies.
Your laws no longer stand.
You rule without the constitution, and therefore have voided any contract that was never signed by any of us in the first place.
We are not cattle, we are not slaves, we are not your property!
We no longer believe in you, and your entire system is just that, one predicated off of religious like belief. You are as real as Santa Claus, the Easterbunny, or the Libor Market!
You are an illusion, and all your power, is based off of nothing more than a vile of ink, paper, and a few 1's and 0's marking a spot for you in the imagination of the web. You are not reality, have no real wealth, and have no real power.
You no longer have our consent.
You are fired!
My sentiments exactly.
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Page 1
Pathologic Diagnosis of Advanced Lung Cancer Based on
Small Biopsies and Cytology
A Paradigm Shift
William D. Travis, MD,* Natasha Rekhtman, MD, PhD,* Gregory J. Riley, MD,†
Kim R. Geisinger, MD,‡ Hisao Asamura, MD,§ Elisabeth Brambilla, MD,¶ Kavita Garg, MD,#
Fred R. Hirsch, MD,** Masayuki Noguchi, MD,†† Charles A. Powell, MD,‡‡
Valerie W. Rusch, MD,§§ Giorgio Scagliotti, MD,?? and Yasushi Yatabe, MD, PhD¶¶
issue of the journal 2, articles address the diagnosis of non-small cell lung cancer
(NSCLC) based on small biopsies and/or cytology, an area of lung cancer diagnosis
in which a paradigm shift has occurred for both pathologists and clinicians.1,2This topic
is important because the majority patients with lung cancer present with unresectable
disease, and the diagnosis is established based on such small specimens. Moreover, with
increasing use of minimally invasive biopsy methods, pathologists are being asked to do
more with less tissue.
ith some exceptions, the field of lung cancer disease has been relatively static during
the past several decades with few major practice-changing advances. In this
The World Health Organization classifications of lung tumors through the 1999
edition3–5did not address lung cancer diagnosis based on small biopsies and cytology,
because these were recommendations for the histologic classifications of resection
specimens. In the 2004 World Health Organization classification, cytology was addressed
for the first time, but classification in small biopsies was not addressed.6Currently, no
internationally recognized standard of criteria or terminology for the diagnosis of lung
cancer in small biopsies is available.
Historically, the most important decision for pathologists in small biopsies and
cytology has been the crucial distinction between small cell lung cancer and NSCLC,
because it defines patients with completely different clinical tumor behavior and man-
agement. Within NSCLC, important clinical reasons to separate squamous cell carcinoma
from adenocarcinoma and other histologic types have not existed.
In a literature review spanning 25 years of clinical studies evaluating chemotherapy
in advanced NSCLC, there was some weak association between histology and therapeutic
*Department of Pathology, †Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York; ‡Department of Pathology, Wake
Forest University, Winston-Salem, North Carolina; §Thoracic Surgery, National Cancer Center, Tokyo, Japan; ¶Service de Pathologie Cellulaire, Centre
Hospitalier Universitaire de Grenoble, France; #Department of Radiology, University of Colorado, Aurora, Colorado; **University of Colorado Cancer
Center, Aurora, Colorado; ††Department of Pathology, Tsukuba University, Tsukuba, Japan; ‡‡Pulmonary Medicine, Columbia University, New York,
New York; §§Thoracic Surgery Service, Memorial Sloan Kettering Cancer Center, New York, New York; ??Thoracic Oncology Unit, University of Torino,
Italy; and ¶¶Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.
Disclosure: The authors declare no conflicts of interest.
Address for correspondence: William D. Travis, MD, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY
10065. E-mail: firstname.lastname@example.com
Copyright © 2010 by the International Association for the Study of Lung Cancer
Journal of Thoracic Oncology • Volume 5, Number 4, April 2010
Page 2
outcomes,7but none of these studies reported a formal test of
treatment by histology interaction. Therefore, in older stud-
ies, there was no clear evidence that histology had a prog-
nostic (independent of treatment) or a predictive role (asso-
ciated with the effectiveness of a specific treatment) for
patients with NSCLC.
Recently, all this has been changed. Three clinical
observations in patients with advanced lung cancer have
provided a reason for pathologists to change their practice
and make a better attempt to distinguish adenocarcinoma
from squamous cell carcinoma. First, patients with advanced
lung cancer treated with bevacizumab are at increased risk for
life-threatening hemorrhage if they have squamous cell car-
cinoma.8Second, patients with adenocarcinoma or NSCLC-
not otherwise specified (NSCLC-NOS; reported as large cell
carcinoma in some of these studies) respond significantly
better to pemetrexed than those with squamous cell carcino-
ma.9–11Third, EGFR mutation is strongly associated with
adenocarcinoma histology, and patients with advanced
NSCLC and EGFR mutation have a better outcome and
response to tyrosine kinase inhibitors' as a first-line therapy,
whereas patients without EGFR mutations seem to have a
better outcome with chemotherapy.12Importantly, in all these
studies, the histologic classification was solely based on light
microscopy with or without mucin stains. No immunohisto-
chemistry or other special techniques were used to classify
the tumors further.
One major underlying problem in addressing more
precise classification of small biopsies and cytology speci-
mens is the inherent histologic heterogeneity that exists in a
subset of NSCLC.2Roggli et al.13addressed this in a com-
prehensive study of 100 lung cancer cases in which 39
adenocarcinomas showed a squamous component in two
cases (5%) and in 27 squamous cell carcinomas (excluding
the cases with small cell carcinoma), adenocarcinoma was
found in four cases (15%). Another difficulty is in tumors in
which a solid component is sampled in small biopsy or
cytology specimens, and the morphologic features of squa-
mous or adenocarcinoma differentiation are focal or not
distinguishable. This has been the subject of numerous arti-
cles that demonstrate the error rate in classification of small
biopsies when compared with final histologic classification of
the surgical specimen.14In one such study, 10% of squamous
cell carcinomas, 14% of adenocarcinomas, and 50% of large
cell carcinomas were misclassified on bronchial biopsies.14
Despite the issues of morphologic heterogeneity and
overlapping features in tumors with solid histology, recent
molecular studies reveal that there are clear biologic differ-
ences between lung adenocarcinoma and squamous cell car-
cinoma. In particular, gene-expression-profiling studies show
distinct molecular clusters for adenocarcinoma and squamous
cell carcinoma.15–17In addition, EGFR and KRAS mutations
are largely confined to adenocarcinoma but are rare in squa-
mous cell carcinoma.18,19
Based on the recent clinical observations, there is a
growing literature regarding the pathologic characteristics
using special techniques to distinguish adenocarcinoma from
squamous cell carcinoma. The current articles by Loo et al.
and Nicholson et al. are the latest additions to this literature.
It seems from the studies by Loo et al.2and Nicholson et al.1
that thyroid transcription factor-1 (TTF-1) and mucin versus
p63 stains are the best stains for detecting adenocarcinoma
versus squamous cell carcinoma, respectively. However,
none of the antibodies used in immunohistochemistry are
100% specific and sensitive for this differential diagnosis. For
example, in the study by Nicholson et al., TTF-1 was positive
only in 13 of the 16 cases (81%), finally classified as adeno-
carcinoma including 4 of the 7 (63%) with adenocarcinoma
morphology and 9 of the 9 (100%) initially diagnosed as
NSCLC-NOS. One case classified as squamous cell carci-
noma also showed occasional staining for mucin. p63 is
consistently expressed in squamous cell carcinoma, but it can
also be seen in a subset of adenocarcinomas. As pointed out
in both the articles, high-molecular-weight cytokeratin anti-
body 34?E12 (CK903) is highly nonspecific for distinguish-
ing adenocarcinoma and squamous cell carcinoma. Despite
the limitations of the individual markers, evidence is emerg-
ing, as demonstrated in these two studies, that high accuracy
can be achieved using a panel approach. A number of other
antibodies have been reported recently including desmocol-
lin-3 and napsin.20–22More prospective investigation is
needed to determine whether these novel markers provide any
added value to TTF-1, p63, and mucin stains to establish the
optimal marker panel for the greatest diagnostic accuracy.
Other molecular techniques, such as micro-RNA, have been
reported to distinguish squamous cell carcinoma and adeno-
carcinoma.23However, whether they provide any advantage
to light microscopy and immunohistochemistry remains to be
determined. Ultimately, a simple panel of stains should be
used that does not exhaust tissue, which may be needed for
predictive and prognostic molecular studies. The combination
of these novel techniques with traditional morphology will
hopefully lead to a more biologically precise classification of
NSCLC in morphologically equivocal cases. Such an ap-
proach has been quite successful in other diseases, especially
in the diagnosis and classification of lymphomas24and sar-
comas.25The prognostic and predictive impact of this ap-
proach for lung cancer will depend on analysis in prospective
clinical studies.
Both articles recognize that light microscopy is suffi-
cient to classify lung cancer in a subset of small biopsies or
cytology specimens, but there remain cases that cannot be
further classified for which they propose to use the term
NSCLC-NOS. Using special stains, the authors identified
characteristics that allowed them to classify most of these
tumors further. Nicholson et al. showed that although 53% of
the cases (17 of 32) were classified as NSCLC-NOS after the
initial light microscopic review, after attempts to perform
Travis et al.
Journal of Thoracic Oncology • Volume 5, Number 4, April 2010
Copyright © 2010 by the International Association for the Study of Lung Cancer
Page 3
special stains 6 of the 32 (19%) remained unclassified.
NSCLC-NOS is a more appropriate term for these unclassi-
fied cases than large cell carcinoma, as has been used in
some, in the absence of standardized criteria and terminology
for small biopsies or cytology.10In some cases in which
biopsies show NSCLC-NOS, but tumor tissue is too sparse
for immunohistochemistry or mucin stains for more precise
classification or for molecular studies, if clinically indicated,
additional biopsies may be warranted. Large cell carcinoma is
a term that should be reserved for classification of undiffer-
entiated NSCLC in resected specimens.
During the past 2 years, the International Association
for the Study of Lung Cancer, American Thoracic Society,
and European Respiratory Society have been developing a
new International Multidisciplinary Lung Adenocarcinoma
Classification. The articles by Loo et al. and Nicholson et al.
are projects that were, in part, generated in response to
questions raised during discussions for this classification.
This classification document will be published soon in the
Journal of Thoracic Oncology.
In this new classification, an algorithm will be pre-
sented with recommended terminology, special stains, and
approaches to tissue management.26Implementation of these
recommendations will require fundamental changes in the
approach of obtaining small tissue and cytology samples by
clinicians, radiologists, and surgeons. It will also require
changes in pathologists' approach to diagnosis including
specimen processing and evaluation, as well as diagnostic
The growing evidence for the utility of ancillary studies
underscores the importance of obtaining sufficient tissue,
whenever clinically feasible.26Although minimal material
may be sufficient to distinguish NSCLC from small cell lung
cancer, additional tissue could be needed to perform immu-
nostains for subtyping of NSCLC. Together with predictive
marker testing (often molecular tests), these new paradigms
emphasize the need for close communication between pathol-
ogists and clinical colleagues to ensure tissue adequacy and
optimal triage for all appropriate diagnostic studies.
Of these two studies, the article by Nicholson et al.
presents the more integrated approach to address this prob-
lem. With their approach, they include biopsy histology,
cytology, immunohistochemistry, and EGFR mutation test-
ing.1Cytology is a powerful modality that, in some cases,
may allow for a more specific classification that is not
possible based on histology or immunohistochemistry. This
article also points out the benefits of making cell blocks from
cytology specimens, to allow for immunohistochemistry or
molecular studies.1Cell blocks were made from pleural
effusions and transbronchial needle aspirations including pro-
cedures that were blinded or guided by esophageal endo-
scopic ultrasound or endobronchial ultrasound.1
With the more important role that is being assigned to
newer diagnostic tests, a critical need exists for clinical trials
that stratify data according to various diagnostic methods
(i.e., light microscopic with or without mucin or immunohis-
tochemical stains), to validate which approach provides the
best discrimination for predicting toxicity or efficacy of
chemotherapeutic regimens and other treatment modalities.
At a minimum, clinical trials should report diagnostic criteria
and methods used to classify tumors from enrolled patients.
Finally, any studies that incorporate new techniques should
compare them with currently accepted ones (i.e., TTF-1 and
p63) to determine whether they provide any added value.
The authors acknowledge all panel members of the
International Association for the Study of Lung Cancer/
American Thoracic Society/European Respiratory Society
Adenocarcinoma Classification for their help in developing
some of the concepts in this editorial.
1. Nicholson AG, Gonzalez D, Shah P, et al. Refining the diagnosis and
EGFR status of non-small cell carcinoma in biopsy and cytologic
material, using a panel of mucin staining, TTF-1, cytokeratin 5/6 and
P63 and EGFR mutation analysis. J Thorac Oncol (in press).
2. Loo PS, Thomas SC, Nicolson MC, et al. Subtyping of undifferentiated
non-small cell carcinomas in bronchial biopsy specimens. J Thorac
Oncol (in press).
3. World Health Organization. Histological Typing of Lung Tumours.
Geneva: World Health Organization, 1967.
4. World Health Organization. Histological Typing of Lung Tumors. Ge-
neva: World Health Organization, 1981.
5. Travis WD, Colby TV, Corrin B, et al. Histological Typing of Lung and
Pleural Tumors. Berlin: Springer, 1999.
6. Travis WD, Brambilla E, Muller-Hermelink HK, et al. Pathology and
Genetics: Tumours of the Lung, Pleura, Thymus and Heart. Lyon,
France: IARC Press, 2004.
7. Hirsch FR, Spreafico A, Novello S, et al. The prognostic and predictive
role of histology in advanced non-small cell lung cancer: a literature
review. J Thorac Oncol 2008;3:1468–1481.
8. Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II
trial comparing bevacizumab plus carboplatin and paclitaxel with car-
boplatin and paclitaxel alone in previously untreated locally advanced or
metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184–
9. Scagliotti G, Hanna N, Fossella F, et al. The differential efficacy of
pemetrexed according to NSCLC histology: a review of two Phase III
studies. Oncologist 2009;14:253–263.
10. Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing
cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemother-
apy-naive patients with advanced-stage non-small-cell lung cancer.
J Clin Oncol 2008;26:3543–3551.
11. Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed
plus best supportive care versus placebo plus best supportive care for
non-small-cell lung cancer: a randomised, double-blind, phase 3 study.
Lancet 2009;374:1432–1440.
12. Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-
Journal of Thoracic Oncology • Volume 5, Number 4, April 2010 Pathological Diagnosis of Advanced Lung Cancer
Copyright © 2010 by the International Association for the Study of Lung Cancer
Page 4
paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947–
13. Roggli VL, Vollmer RT, Greenberg SD, et al. Lung cancer heterogene-
ity: a blinded and randomized study of 100 consecutive cases. Hum
Pathol 1985;16:569–579.
14. Cataluna JJ, Perpina M, Greses JV, et al. Cell type accuracy of bronchial
biopsy specimens in primary lung cancer. Chest 1996;109:1199–1203.
15. Fujii T, Dracheva T, Player A, et al. A preliminary transcriptome map of
non-small cell lung cancer. Cancer Res 2002;62:3340–3346.
16. Bhattacharjee A, Richards WG, Staunton J, et al. Classification of
human lung carcinomas by mRNA expression profiling reveals distinct
adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001;98:13790–
17. Takeuchi T, Tomida S, Yatabe Y, et al. Expression profile-defined
classification of lung adenocarcinoma shows close relationship with
underlying major genetic changes and clinicopathologic behaviors.
J Clin Oncol 2006;24:1679–1688.
18. Kosaka T, Yatabe Y, Endoh H, et al. Mutations of the epidermal growth
factor receptor gene in lung cancer: biological and clinical implications.
Cancer Res 2004;64:8919–8923.
19. Tam IY, Chung LP, Suen WS, et al. Distinct epidermal growth factor
receptor and KRAS mutation patterns in non-small cell lung cancer
patients with different tobacco exposure and clinicopathologic features.
Clin Cancer Res 2006;12:1647–1653.
20. Ring BZ, Seitz RS, Beck RA, et al. A novel five-antibody immunohis-
tochemical test for subclassification of lung carcinoma. Mod Pathol
21. Monica V, Ceppi P, Righi L, et al. Desmocollin-3: a new marker of
squamous differentiation in undifferentiated large-cell carcinoma of the
lung. Mod Pathol 2009;22:709–717.
22. Bishop JA, Sharma R, Illei PB. Napsin A and thyroid transcription
factor-1 expression in carcinomas of the lung, breast, pancreas, colon,
kidney, thyroid, and malignant mesothelioma. Hum Pathol 2010;41:
23. Lebanony D, Benjamin H, Gilad S, et al. Diagnostic assay based
on hsa-miR-205 expression distinguishes squamous from nonsqua-
mous non-small-cell lung carcinoma. J Clin Oncol 2009;27:2030–
24. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of
Tumours of Haematopoietic and Lymphoid Tissues, 4th Ed. Lyon:
International Agency of Research on Cancer, 2008.
25. Fletcher CD, Unni KK, Mertens F. Pathology and Genetics: Tumours of
Soft Tissue and Bone. Lyon: International Agency for Research on
Cancer Press, 2002.
26. Travis WD, Brambilla E, Noguchi M, et al. The new IASLC/ATS/ERS
international multidisciplinary lung adenocarcinoma classification.
J Thorac Oncol (in press).
Travis et al.
Journal of Thoracic Oncology • Volume 5, Number 4, April 2010
Copyright © 2010 by the International Association for the Study of Lung Cancer

subset: commoncrawl


text:
San Diego Chargers Should Think about Signing Shonn Greene
The San Diego Chargers had one of the worst rushing attacks in the NFL during the 2012 season. San Diego ranked 31st in yards per rushing attempt and was tied with the Oakland Raiders for last in rushing touchdowns.
A major problem was the decline of Ryan Mathews who averaged a career low 3.8 yards per attempt to go along with a career low one rushing touchdown. San Diego has to do something to improve their rushing attack.
I suggested that San Diego's front office should go after Miami Dolphins running back Reggie Bush who could be a free agent. Another guy who San Diego's front office should consider is New York Jets RB Shonn Greene.
Greene is coming off back-to-back 1,000 yard rushing seasons to go along with six rushing touchdowns in 2011 and eight in 2012. Greene will be a free agent unless New York uses the franchise tag on him.
Greene is a very dependable running back because he missed three games in four seasons compared to Mathews who missed 10 games in three seasons. Greene and Mathews could split attempts which would limit the chances of Mathews suffering an injury.
I expect San Diego's front office to make a move that will improve the rushing attack and limit Mathews' chances of being injured. The one knock on Greene is that in four seasons, his longest rushing attempt went for 36 yards. However, if Greene and Mathews split attempts, Mathews could be the speed guy while Greene could be the power guy.
An improved rushing attack for San Diego in 2013 could open up the field for their receivers and take pressure away from Philip Rivers at the quarterback position.
Greene could be a great fit with the Lighting Bolts and I believe that a two headed monster at the RB position is the right direction for San Diego's front office to go in.
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text:
New Energy Finance Podcast on Offshore Wind
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text:
Jeremy Lin
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Joseph: Nonu's a no-go but Woodcook, Hore may stay
Relevant offers
Highlanders coach Jamie Joseph says the door remains firmly shut on Ma'a Nonu but he won't know until this weekend if Andrew Hore and Tony Woodcock are also exiting the Highlanders.
While there was no chance of Nonu being welcomed back to Dunedin, Joseph refused to say fellow All Blacks Hore and Woodcock were also goners.
There have been reports hooker Hore, who turns 35 today, would retire after the Rugby Championship ended.
Loosehead prop Woodcock, after just one season at the Highlanders, has been contemplating a return to the Blues.
Given that Hore and Woodcock have 180 test caps between them it seems strange Joseph hasn't recently talked to them to confirm their plans for next season.
However, he said clogged schedules had prevented this: the players had been busy with the All Blacks, while he had only returned from a fortnight in the United States last Friday.
"The Ma'a thing for me is dead in the water," Joseph said. "That's pretty obvious for me and the Highlanders.
"But with 'Horey', respectfully, I haven't had a chance to talk to him because he has been playing test matches and I have been busy.
"I am going to catch up with him this weekend. We haven't actually had a chance to have a good yarn and sit down."
Joseph indicated that if Hore played another season it may convince his fellow front rower to stay with the Highlanders.
"The thing around 'Woody' is that he is very close to 'Horey' and his decision to come south was because of the chance to play with his friend," Joseph added.
"And so I can only assume his decision is based on what he [Hore] is up to. After that [this weekend's meeting] we will know what is happening."
Hore joined the Highlanders last year after he was booted out of the Hurricanes by coach Mark Hammett.
Yesterday All Blacks coach Steve Hansen acknowledged Hore didn't figure in his plans for the 2015 World Cup, stating he may "retire this year or next year".
Joseph, who will again be assisted by Jon Preston and Scott McLeod next year, wasn't concerned he still didn't know about Hore's plans.
"It is no different to what has actually happened every year with 'Horey' because he is a pretty cruisy guy. It is just the way it is."
Nonu wants to go back to the Hurricanes.
But Hammett, who sacked him in 2011, was having none of that. His rejection led to speculation the New Zealand Rugby Union may ask Joseph to offer Nonu a reprieve.
"That's the first I have heard about that," Joseph, who hasn't spoken to Nonu since the Highlanders season ended, said.
"We offered the player a contract in April and his reluctance to make a commitment in that time means that contract offer has lapsed and everything else has unfolded beneath my eyes and your eyes. We have just moved on."
Nonu also did his relationship with Joseph few favours by getting red carded for a spear tackle on the Crusaders Tom Marshall on June 29, just days after Nonu has produced some spectacular form for the All Blacks.
The Highlanders, who finished 14th this season, have already lost All Blacks Hosea Gear, Colin Slade, Jamie Mackintosh and Tamati Ellison.
Joseph wanted Ellison back next year but the NZRU refused to grant the midfielder a dispensation because he skipped the NPC to play in Japan.
He has since signed for the Melbourne Rebels.
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Richie McCaw locking horns with Bulls for last time at Loftus Versfeld
Is the Canterbury team 'mentally soft'?Related story: North Harbour stun hapless Canterbury team


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P-Mation #41: A-Door-Able
Blue boy meets his lovely neighbor!4.46 / 5.00 8,263 Views
Otherworld - Quiet Luke
in da othawurld4.42 / 5.00 4,456 Views
Joe vs the Environment
In collaboration with Earth Hour 2015 and Pocoyo4.08 / 5.00 2,235 Views
pretty good
thare is a Laugh out loud radio 104.3 in my area awesome
the SHUSH!
The caller was hillarious
I have to say the caller made me laugh. I would say just fix the constant loop if anything.


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2-Piece Set: U.S. Traveler Rio 21" Upright & 14" Tote - Assorted Colors
$35.00 Our Price
$99.99 Retail
You've waited so long for this time to arrive--you're finally going on vacation! You're so excited that you're started packing a week early, and it's a good thing you did, since you discovered that you don't have enough room for everything you need in your tiny little bag. If only you had the U.S. Traveler Rio 2-Piece Luggage Set. This great set comes with a 21" upright case that expands to give you even more space, as well as a matching carry-on travel bag. This set pairs beautifully together and gives you plenty of space for all your essentials, plus it's durable and looks great, too! Want to know more? • 5-year manufacturer's limited warranty • Luxurious superior 1200D rigid polyester construction • Interior deluxe retractable push-button, self-locking handle system • Inline skate wheels with corner protectors • Expandable (25% more packing capacity) • EVA padded front panel for extra durability • Multiple front pockets • Top and side carry handles • Solid metal hardware • Large zippered mesh lid pocket • Dual adjustable tie down straps • Full interior lining • Upright measures: 21" H x 13.5" W x 8.5" D (expands to 10.5" D); weighs 6.6lbs • Travel tote measures: 14" W x 10" H x 6" D; weighs 1.3lbs • Available in your choice of Blue or Green
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Beijing sends ships to Yemen to evacuate Chinese nationals
Russian forces to practise use of S-300, S-400 against air, missile strikes
OSCE investigates civilian vehicle shelling in east Ukraine — militia
Russian Air Code bans aircrews to leave any pilot in cockpit alone
Finnish owners to re-register Crimean winery under Russian law
OSCE investigates civilian vehicle shelling in east Ukraine — militiaWorld March 30, 12:13
No nearing solution on future of Iranian enriched uranium stockpile — US delegation sourceWorld March 30, 12:03
Some 3.5 tons of Afghan heroin worth $1 billion seized in Russia in 2014Russia March 30, 11:51
Russian forces to practise use of S-300, S-400 against air, missile strikesRussia March 30, 11:38
Russian Air Code bans aircrews to leave any pilot in cockpit aloneRussia March 30, 11:34
Russia's VTB bank wants to obtain Chinese agency Dagong rating — CEOEconomy March 30, 11:28
Kiev court cancels hearing on ban of Ukraine's Communist PartyWorld March 30, 11:16
Beijing sends ships to Yemen to evacuate Chinese nationalsWorld March 30, 10:57
Russia's VTB bank considers entering Shanghai Stock Exchange — CEOEconomy March 30, 10:53
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BEIJING, April 09. /ITAR-TASS/. Russia's Gazprom and China are poised to conclude a gas supply contract in coming weeks, the first in a series of energy projects planned between the two countries.
"We're working now to sign a gas contract in May," said Deputy Prime Minister Arkady Dvorkovich. "Consultations are continuing and Gazprom's leaders are holding talks with Chinese partners on the contract terms. We hope to conclude the contract in May and believe it should come into effect by the year end."
"Base price is the only problem to be solved," Dvorkovich said on Wednesday at a session of a Russia-China intergovernmental commission on energy co-operation, co-chaired by Chinese Vice-Premier Zhang Gaoli.
In other plans, Russian company Novatek's Yamal region LNG (liquefied natural gas) project was near ready for signing, Drovkovich said. Russia's Rosneft had several interesting plans "seeking to increase maritime supplies by several million tonnes per year," he said.
"Russia and China have agreed to jointly develop gas fields in (Russia's far eastern) Sakhalin and East Siberia," Dvorkovich said. "We have discussed co-operation in the coal sphere, agreeing to develop deposits, supply equipment and build electric power plants as well as providing China with additional electricity supplies".
"We're finding mutually advantageous decisions on certain projects that will allow us to implement them in the shortest period of time," Dvorkovich added. Conditions were right to speed the Tianjin oil refinery project and to build a petrochemical facility, he said.


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List all words starting with ngultrum
2 words found.
List all words starting with ngultrum sorted by length or by how common the words are.
Some random words: fatness aoudad twibil aftmost toss vying oilily
This is not a dictionary, it's a word game wordfinder.
- Help and FAQ - Examples - Home
Privacy Policy - Share - © Copyright 2004-2015 Morewords.com - 0.972mS


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List all words that contain tubal
Only the word tubal was found, nothing longer.
Some random words: rowlock otic eelgrass abhenries hi eger jiao
This is not a dictionary, it's a word game wordfinder.
- Help and FAQ - Examples - Home
Privacy Policy - Share - © Copyright 2004-2015 Morewords.com - 70.250mS


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6 May 2014
UK private equity firm Actis is looking to sell a substantial part of its majority interest in Ugandan power group Umeme.
Read full story
24 April 2014
Emerging markets-focused investment firm Actis has bought Africa's largest independent credit bureau Compuscan.
22 April 2014
UK emerging market firm Actis has completed a "significant" investment in mobile monetisation company Upstream.
16 April 2014
African private equity investment is now outperforming the North American and European markets in relative returns according to new research from EY.
Global private equity giant Carlyle has raised the largest ever first time fund targeting sub-Saharan Africa fund by holding a $700m final close.
Singapore sovereign wealth investor Temasek and the IFC have committed $255m to Nigeria-based Seven Energy International to boost its gas supply business in the country's developing energy market.
14 April 2014
Africa-focused private investment firm Helios Investment Partners has raised $355m towards its $1.16.5bn-targeting third fund, Helios Investors III.
11 April 2014
West African fund manager Cauris has tapped its second fund to invest in Cote d'Ivoire pharmaceutical company CIPHARM.
10 April 2014
The majority of South African companies that have received private equity backing say that private equity has helped grow their business, according to a research report.
2 April 2014
Africa and Asia-focused insurance group Bima has raised a $22m round to fund its plans to expand into new markets including Paraguay, Cambodia, and the Philippines.
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What's On
Expired Event - Joshua Yeldham - An Exhibition - 19 Sep 2014
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Joshua Yeldham - An Exhibition
Every day until Sun 02 Nov 2014
An exhibition exploring the work of one of Australias most unique and creative contemporary artists, through film, painting, photography and sculpture. This exhibition reveals Joshua Yeldhams early creative inspiration, and spiritual journey into the Australian landscape, in particular Pittwater and the Hawkesbury River, a region he has know since childhood. The exhibition takes the audience on a journey past jagged sandstone cliffs, along river banks, through twisted spotted gums and oyster leases, recording the beauty and timelessness of the landscape.
Manly Art Gallery and Museum, West Esplanade, Manly
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Rolta India Ltd wins contract for establishing "National NAVTEX Network" from a subordinate office under the Ministry of Shipping, Road Transport & Highways, Government of India, that provides general aids to navigation along the Indian coast.
NAVTEX is an international automated medium frequency service for delivery of navigational and meteorological warnings and forecasts, as well as urgent marine safety information to ships. NAVTEX is a component of the International Maritime Organization / International Hydrographic Organization, Worldwide Navigation Warning Service (WWNWS) and is also a major element of the Global Maritime Distress Safety System (GMDSS).
The Indian NAVTEX system to be deployed by Rolta will provide coverage up to 250 nautical miles (460 km) from the Indian coast line and will transmit maritime navigational and meteorological warnings and forecasts, as well as urgent marine safety information to ships at sea in Indian waters. This network will consist of 7 interlinked broadcasting sites to cover the entire Indian coastline with a Command & Control Centre on the Western coast and an identical Command & Control Center on the Eastern coast.
This Indian NAVTEX Network is the first of its kind for the country. Rolta's success in winning this project is a part of its foray in the diversified domains of Communications, Optronics and Command & Control for the Defence and HLS markets.
Commenting on the occasion, Chairman and Managing Director of Rolta, Mr. K. K. Singh said, "We are delighted to have been given this opportunity to establish such a high-tech communication network system for the safety and security of ships in coastal waters of India. This state-of-the-art solution will place India amongst select developed nations worldwide that have similar sophisticated systems in place".
Trade unions Unite and GMB said members working offshore in Britain's North Sea oil and gas industry had shown overwhelming support for industrial action in a consultative
URAG has taken delivery of two ASD 2411 Tugs to add to its existing fleet. Named Brake and Perfect, the new vessels have joined their sister ship Prompt in the
Ocean Safety has introduced a new range of workwear lifejackets.
The new Kru Workwear range completes Ocean Safety's lifejacket offering, providing a wide choice
Washington State Ferry M/V Tacoma will return to work on the Seattle/Bainbridge Island route starting March 28 after suffering electrical damage last summer.
Building Capacity, as Deadline for Trained Crews Nears
"You see that ship. That's our ship," says Karsten Saevik, as he directs our attention to the virtual
For anyone involved in maritime training, now is an incredibly exciting time full of opportunity. More than ever before, there are new advanced techniques and technologies
Olaf Wiertz, Sales Director at Schmiedag GmbH (SDG) and Wildauer Schmiedewerke GmbH & Co. KG (WSW) said: "We are more than just a supplier to our customers – we are their partner.
With ESPRIT CAM software, Armor Mécanique has the wind in its sails; 50% time savings, better quality and new markets thanks to 3D machining
Established in 1984
The Wall Street Journal ran a story yesterday describing how the increasing number of seaborne migrants making the journey from Africa to Europe has not only
As Saudi Arabia and its Arab allies stage air strikes against Shi'ite Muslim militiamen threatening to topple Yemeni President Abd-Rabbu Mansour Hadi, the southern
The Greek ferry that ran aground just outside of port on the Aegean Island of Kassos Wednesday night is still stuck.
The 227 passengers and 55 crew aboard the
SATCOM edges closer to providing standardized services to the workboat sector. It's affordable now and someday soon, you won't be able to afford to be without it.
As Satellite providers battle for market share, the onboard struggle to efficiently maximize bandwidth allocation is also being solved.
The requirement to monitoring
There's a digital disconnect offshore. The communication standards we take for granted on land are cut adrift at sea; hampering data transfer for businesses, while


text:
Oakville man swims across Lake Ontario in 24 hours
Madhu Nagaraja is the first person to complete the tough swim this summer. Injury forced swimmer François Hamel to abandon his attempt early Sunday.
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Madhu Nagaraja reached his goal of swimming across Lake Ontario on Sunday, hours after injury ended another swimmer's dream of completing the same feat.
Nagaraja arrived at Coronation Park in Oakville, only a few blocks away from his home, at 9:37 p.m.
He overcame fatigue and strong overnight winds to complete what is considered one of the three toughest swims in the world. According to the Lake Ontario Swim Team, he's the 50th person to make the crossing.
About 150 of Nagaraja's friends and family members cheered for him when he touched shore, friend and land crew member Doug Harrison said.
"He's got a strong will. He sets a goal and he does it."
Nagaraja and a boat of 12 crew members left Port Dalhousie at 9:08 p.m. on Saturday.
Among his companions were a coach, navigator, doctor and three pacers who took turns swimming with him and offering encouragement.
Earlier Sunday, 42-year-old François Hamel abandoned his swim across Lake Ontario after injuring his left shoulder.
When the aviation instructor could not lift his left arm out of the water to complete each stroke, he knew something was wrong. A discussion with his coach convinced him to pull out.
"He is doing fine," said Katherine Czok. "He feels he made the right decision ... had he gone longer he could have seriously injured himself."
Hamel had dedicated his 52-km swim to the Juvenile Diabetes Research Foundation, raising $12,000.
Hamel and Nagaraja are two of seven swimmers aged between 14 and 60 attempting to swim across Lake Ontario this summer.
Knowing how much work it is to plan a swim across the lake, Nagaraja's team was cheering on Hamel and felt bad when he withdrew, Harrison said.
Nagaraja spent 10 months training for the Lake Ontario challenge. In 2004, he crossed the English Channel in 12 hours and 31 minutes.
"He's a very accomplished adventurer if you take a look at what's he done in his life," Harrison said.
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Lego under fire for custom toy that can't have girls' names
The Danish toy maker has apologized for failing to provide naming options for both genders.
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In a world where personalization and customization are increasingly important corporate values, Lego has caused a minor kerfuffle with an online toy-making template that only allows boys' naming options.
Lego's Hero Recon line, which is the successor to the company's successful Bionicle line of futuristic robot creatures, features an online template for customers to build a custom creature, adding armour and accessories. Created as part of Lego's DesignbyMe initiative, the toy can be ordered or used in online games on the Lego site once completed.
The final step of the process prompts the user to create a code name for the character before adding it to the site's online gallery. There are three naming fields involved. The first has 22 boys' names to choose from, ranging from Alexander to William. The other two feature generic names of an extreme bent, like Missile, Shock, Shadow and Stinger.
The lack of girls' naming options has disappointed fans. One fan contacted Lego's customer service department and received this response:
"The members of LEGO Hero Recon currently can't be given a girl's name. We're looking into making sure that we get this changed as quickly as possible though! We don't want to make anyone think that there aren't girl Hero Recon team members. This was an oversight that we will be looking at fixing. Please accept our apologies."
Michael McNally, brand relations director for Lego, told the Star the company is looking for a quick fix. "As one of the most prominently featured heroes in the (Hero Factory) storyline, Breez, is female, it was a miss to not include girls' names in the options for Hero Recon Team," he said in a statement.
Marcia MacQuarrie, the editor of The Noise on Toys, an independent online consumer guide, isn't all that surprised by Lego's lack of girls' options.
"With only 22 name choices, it's not terribly personalized personalization," says MacQuarrie. "The thing is there are a lot of girls that like these types of toys and they are not really recognizing that."
She says the company has more success targeting girls in Europe, adding that it wouldn't be difficult to add girls' names to the Lego Hero Recon team. It is clear that the idea is to appeal to boys with this particular product and online environment, says MacQuarrie.
For a better example of personalized toys, she recommends the Leapfrog series, which offer many naming options for both boys and girls – a thrill for children who love toys that incorporate their given names.
Lego is coming up against a problem many shopping sites face when offering custom products. The question is whether to allow complete freedom or a set number of options. Sports leagues and jersey sellers have faced some criticism for setting their online filters too high, rejecting many customers' chosen names.
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Download our free information covering all aspects
What are the symptoms?
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Monday 13 May 2013
- bowelcancer @sarahbluecheese @TeamElmtonCRH @royalhospital thank you so much for all your support - looks great!
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- bowelcancer RT @kevin11sheedy: Show your support for @bowelcancer this month and buy a bum badge from our Everton shops. @Everton @bowelcancer
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New farnesyltransferase inhibitors in the phenothiazine series
ABSTRACT The biological screening of the chemical library of our Organic Chemistry Department, carried out on an automated fluorescence-based FTase assay, allowed us to discover that a phenothiazine derivative (1d) was an inhibitor of farnesyltransferase. Three new series of human farnesyltransferase inhibitors, based on a phenothiazine scaffold, were synthesized with protein farnesyltransferase inhibition potencies in the low micromolar range. Ester derivative 9d was the most active compound in these series. Four synthesized compounds were evaluated for their antiproliferative activity on a NCI-60 cancer cell line panel. The modest results obtained in this preliminary investigation showed that mixing the phenothiazine and the 1,2,3-triazole motif in the structure of a single compound can lead to new scaffolds in the field of farnesyltransferase inhibitors.
SourceAvailable from: Hitoshi Tsujimoto[Show abstract] [Hide abstract]
ABSTRACT: Recently, the bed bug, Cimex lectularius L. has re-emerged as a serious and growing problem in many parts of the world. Presence of resistant bed bugs and the difficulty to eliminate them has renewed interest in alternative control tactics. Similar to other haematophagous arthropods, bed bugs rely on their olfactory system to detect semiochemicals in the environment. Previous studies have morphologically characterized olfactory organs of bed bugs' antenna and have physiologically evaluated the responses of olfactory receptor neurons (ORNs) to host-derived chemicals. To date, odorant binding proteins (OBPs) and odorant receptors (ORs) associated with these olfaction processes have not been studied in bed bugs. Chemoreception in insects requires formation of heteromeric complexes of ORs and a universal OR coreceptor (Orco). Orco is the constant chain of every odorant receptor in insects and is critical for insect olfaction but does not directly bind to odorants. Orco agonists and antagonists have been suggested as high-value targets for the development of novel insect repellents. In this study, we have performed RNAseq of bed bug sensory organs and identified several odorant receptors as well as Orco. We characterized Orco expression and investigated the effect of chemicals targeting Orco on bed bug behavior and reproduction. We have identified partial cDNAs of six C. lectularius OBPs and 16 ORs. Full length bed bug Orco was cloned and sequenced. Orco is widely expressed in different parts of the bed bug including OR neurons and spermatozoa. Treatment of bed bugs with the agonist VUAA1 changed bed bug pheromone-induced aggregation behavior and inactivated spermatozoa. We have described and characterized for the first time OBPs, ORs and Orco in bed bugs. Given the importance of these molecules in chemoreception of this insect they are interesting targets for the development of novel insect behavior modifiers.PLoS ONE 11/2014; 9(11):e113692. DOI:10.1371/journal.pone.0113692 · 3.53 Impact Factor
Article: Peptide chemistry applied to a new family of phenothiazine-containing inhibitors of human farnesyltransferase.[Show abstract] [Hide abstract]
ABSTRACT: Novel phenothiazine derivatives bearing an amino acid residue were synthesized via peptide chemistry, and evaluated for their inhibitory potential on human farnesyltransferase. The phenothiazine unit proved to be an important bulky unit in the structure of the synthesized inhibitors. Propargyl ester 20 bearing a tyrosine residue exhibited the best biological potential in vitro in the present study. Further syntheses and biological evaluation of phenothiazine derivatives are necessary in order to gain a full view of SAR in this family of farnesyltransferase inhibitors.Bioorganic & Medicinal Chemistry Letters 05/2014; DOI:10.1016/j.bmcl.2014.04.102 · 2.33 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Phenothiazinyl units have been covalently attached to graphene oxide (GO) by nitrene insertion onto CCarbon 08/2014; 74:113–119. DOI:10.1016/j.carbon.2014.03.011 · 6.16 Impact Factor


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Blaine News
Local news for Blaine, TN continually updated from thousands of sources on the web.
The Wine That Saved a Knoxville Landmark
Friday Mar 6 | The Daily News | Comment?
National Register of Historic Places adds three sites in Tennessee
Jan 20, 2015 | Clarksville Online | Comment?
Three Tennessee Sites Added to the National Register of Historic Places
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Blaine woman sells hand painted cards at Downtown Knoxville bookstore
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Hard Freeze Warning for Grainger County was issued at March 28 at 3:04AM CDT
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Written on: 19/11/2012
I would reccomend to my friends. AR offers are great, lots of hotels and the pricing is wonderfull! I use AR a lot.Visit alpharooms.com
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So Many Roads - Today's Christian Videos
Embed soundingjoy 2303 views 2010-10-01T23:43:04 There is a way that seems right to man but the end thereof is death. God has called us to follow His straight and narrow path that leads to a perfect place in Him.
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Deviant Art
.We All Die Inside From Lack of Comfort."Sometimes I tremble in my seat so badly it worries myself, but nobody sees me to ask if I am okay. But I have to remind myself, if they did ask I wouldn't have a response. Either if I was okay, fine or living hell...I would always respond with I don't know, I don't know myself, feelings. I can't understand, and when I can't understand it everything hurts. I shouldn't even care or worry about responses. Because people don't notice me and don't have the audacity to make sure someone's okay. We all die inside from the lack of comfort." -Nike.We All Die Inside From Lack of Comfort.2 years ago in Introductions & Chapters More Like This
5 things you didn't know you knew about Annabeth1. Her ears always turn red when she's embarrassed5 things you didn't know you knew about Annabeth2 years ago in Personal More Like This
2. When she's nervous, she tucks a small curl behind her ear
3. She wore a black camo tank top during the entire battle of tLO
4. She has worn makeup twice during the original series... Did you notice when?
5. She's cried five times in front of Percy before they were a couple, can you name all the times?
All this is right from the books. You just probably never noticed it. Or did you?
10 ways to annoy Leah Clearwater 10 ways to annoy Leah Clearwater10 ways to annoy Leah Clearwater3 years ago in Humor More Like This
10) Ask if she still has feeling for Sam.
9) Ask her about Emily.
8) Ask why does she HAVE to take out her anger on everyone else. Add "Geez Leah" in the end.
7) Ask her how does it feel to be surrounded by muscular shirtless guys, make sure to add "You lucky whore, I want thaaat!" and stomp your foot like a fangirl would.
6) Tell Renesmee (Teenage) That Leah and Jacob would have ended together, if it wasn't for her. Make sure Leah hears you.
5) Tell her it is possible that Seth is a pimp and he sleeps with girls behind her back.
4) Ask her why she joined Jake's pack. Add "Is it because you have feelings for him? I don't blame you."
3) While arguing with her shout "At least I'm not barren like you!"
2) Tell her to rip the umbilical cord - Seth ain't little anymore.
What's the number one way to annoy Leah Clearwater?
1) Tell her that the guys are dogs and she's the b word, add "You know the female dog?" Videotape her reaction.
.Fine."I'm bored.".Fine.2 years ago in Short Stories More Like This
"Too bad."
"What do you mean to bad?"
"Too bad I'm letting you suffer." Danielle smirked at him, sitting on his stomach and running her fingers past his bronze hair.
"You're so good to me; I'm just so spoiled." Nico rolled his eyes his tone sarcastic.
"Oh please, I hate you." She grinned at him.
"Love you too." He smirked, but stopped as she kneed him down there, getting off of him.
Danielle just watched him double over in pain with a smirk, of course not having any guilt for him.
"And you hurt me so much. Lucky me." Nico muttered, slowly sitting up. "And it still hurts."
"And you caused the pain, so you have to fix it." He smirked.
"No thank you."
"Then I'll do it myself," he murmured, getting up and heading upstairs. Making her wonder what he'd actually do.
.Don't Be Afraid- Gay/Lesbian=PEOPLE.Hell, I might make a series on Don't Be Afraid with some topics that piss me off..Don't Be Afraid- Gay/Lesbian=PEOPLE.2 years ago in Personal More Like This
Gay/Lesbian people. I don't even want to call them gay or lesbian because they are still people.
And what inspired me to do this? Ignorant people.
Ignorant people inspired me.
Now if you're one of the ignorant people out there, I understand I won't hate you. I respect everybody, I respect everybody's opinion.
But it does bother me of why you judge people of their being. Is there a reason?
But if your reason is selfish, as like they need to be same as you and like the different gender then just get out.
Get out.
There is NO reason everybody should be the same.
But hell, I grew up around with a brother. Yes, yes most of you know him.
And he dragged me into being more guy like since I didn't have a sister.
And he is the blame that I am bi-sexual
I became aware of being bi-sexual at 6th grade but a girl came up to me and said: I saw a girl couple walking down the street hand in hand it was gross. And she was
.Two Ways."There are only two ways to live your life. One is as though nothing is a miracle. The other is as though everything is a miracle.".Two Ways.2 years ago in Short Stories More Like This
― Albert Einstein
.I'll.Nico leisurely walked over to Danielle as she was just looking out the window of the kitchen. He wrapped his arms around her waist, picking her up and settled her down on the counter and leaned forward, his hands planted at the sides. "I'm bored." He mumbled..I'll.2 years ago in Short Stories More Like This
"Get used to it."
"I can't."
"Why not?"
"Because I'm bored of being bored with boring and boring doesn't go well with me." Nico complained but Danielle gave him a gentle shove back with a short chuckle.
"Too bad." She hopped off the counter.
"You're unfair." Nico whined.
"Life's unfair, you and me are up against the boring."
"Or"he quickly picked her up again pressing her against the wall"you and me up against the wall having fun." He murmured into her ear.
Danielle huffed, wanting to shove him away but she already fell for him as his lips eventually ended up on hers. "Nico." She huffed, chuckling as he gave her a naive look.
"We can't."
"Why not?" he huffed.
"Because I'll rather have you suffer in boring." Danielle smirke
Announcements Raiding Update - 12/7/2014Announcements3 years ago in Personal More Like This
Raiding has had a revamp! It is now MUCH easier to raid- all's it takes is a simple comment, once a week! Because it now takes less effort, the prizes and the frequency at which you can raid have been reduced. See the update here:
Winter Solstice - 12/2/2014
The Harvest Festival event is now closed, making way for the Winter Solstice! See the front page for event information. Don't forget that participating in the Winter Solstice will earn you an achievement!
Also, just a reminder that we now have a skype group. Give Umbrafen your skype name for an invite! So far it's been a success
Profession System Updates - 10/24/2014
Some small updates have been made! New achievements have been added for the coliseum, holiday event participation, and for t
.Bitches.You can still be PRETTY or BEAUTIFUL or SKINNY or PERFECT..Bitches.2 years ago in Short Stories More Like This
Just don't be a snob about it.
.Here Take This Too.Chester was at camp. He hated camp. He hated the food. He hated the loud Ares kids that would try to stick something into his hair. He hated camp, sometimes wanting to sock someone in the nose..Here Take This Too.2 years ago in Short Stories More Like This
But he was just sitting at the Hephaestus table, eating. He abnormally stayed quiet, feeling strange around his stranger siblings. But they seem they didn't give two flying fucks at him so he stayed out of the conversation. He finally learned you can't finish all your food either, you'd have to send it as an offer to your god parent. Bullshit he would always think.
Chester finally just got up as he finished half of his food, walking to the fire pit to toss his father an offer. He huffed, scraping the food into the fire. But he bit his lip, finding it not so much.
"Here, take the plate too." He tossed the paper plate in as well, "and the fork."
|Sta.sh Submit


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Saturday, 28 March 2015
Last updated 16 hours ago
Jun 23 2006 | 8:31pm ET
Stanford University boasts an impressive roster of entrepreneurial alumnae. Now, two of the university's Ph.D students are hoping to make their mark on the financial world even before they graduate.
Oren Shiran and Stefan Tang have taken leave from the school's computational and financial mathematics program and are utilizing their quantitative skills to manage money in the real world. Last August, the two twenty-something-year-olds launched QMHF Capital Management, a long-short hedge fund that employs a directional-quantitative strategy.
Shiran, who has a bachelors of science in electrical engineering and computer science from the University of California, Berkeley, explains that the proprietary system that he and Tang utilize means that there is not a lot of human involvement with trading.
"We are very systematic," he said, explaining that they do not utilize historical data to predict the future, which a lot of quantitative models do. "We don't believe in that, we trade only based on concepts and not on pattern recognition."
The fund invests in U.S. equities across all sectors and market capitalizations, though it limits its exposure in micro-cap stocks in order to reduce risk. The pair relies on proprietary algorithms and computer models to sift through the myriad pieces of information in the markets in order to find hidden inefficiencies.
"Because there is a large amount of data out there, and because analysis of this data is very complex, we can use more artificial intelligence and computational finance methods to find the sort of market nuances that we are looking for," he said. "The concept of identifying market inefficiencies is well known, but actually how to identify a specific situation that yields a profit opportunity is quite complex when you have so much data."
While at Stanford, Shiran and Tang worked on research projects under Gene Golub, a world-renowned professor who specializes in computational methods and matrix manipulation. However, the two have admittedly never managed money professionally before launching their venture last year.
"We don't have a lot of experience in professional money management, so that is a hurdle," said the soft-spoken Shiran, explaining that his goal is to prove the strategy through the fund's track record. "I think our door will open up a little bit more once we get a year behind us."
Shiran and Tang's long-term goal is to build up the firm, which currently has $2 million in assets under management, to be a billion-dollar business.
Mar 26 2015 | 11:11am ET
Funds that mimic strategies used by active managers for a fraction of the cost could...
Mar 25 2015 | 6:51pm ET
Trouble at home leads to trouble in the market for fund managers, according to researchers...
Mar 26 2015 | 1:06pm ET
High-frequency trading has been a persistent storyline for several years. The trading...
Mar 9 2015 | 6:35am ET
As more investors look to diversify, many are beginning to use retirement funds to invest in alternative assets such as private equity and real estate. Kelly Rodriques, CEO & President of PENSCO Trust Company, explains how companies can connect with those looking to use their retirement accounts in a different way. Read more…
Mar 20 2015 | 12:45pm ET
StreetWise Partners, a non-profit organization that works with low-income individuals to help them overcome employment barriers, raised over $275,000 at the 2015 Raising the Ante Charity Poker Tournament and Casino Event last Wednesday evening at Capitale. Here are some photos from the event. Read more…


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A weekly opportunity for Jewish meditation led by Rabbi Richard Hirsh.
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Main Line ReformTemple joins together with Bryn Mawr Presbyterian Church for dinner followed by a presentation by Stephen R. Treat, senior staff therapist and former director and CEO of Council for Relationships, on exploring ways to manage the limitations, physical and otherwise, that aging inevitably presents. We will discuss how to face the future and move forward with grace and dignity.
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Gay Male Series
Gay Male Series
Forgetting the PastHe loved him once, but not anymore.
FoundWhat is lost will soon be found-werewolf and his mate.
Fountain of YouthA young twink is seduced by an older man.
Four FriendsLong-term partnership is threatened by their best friend.
Fraternal LoveBraxton hasn't seen his brother for ten years.
FreaksAtlas and Brian build to release.
Free at LastAn angry Russian and a hospital.
Free WolfLonely weretiger meets alpha werewolf.
FreezingFirst time sucking cock.
Fresh OutNeville starts his new life.


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Holdays.net Home
This listing is plate entitled "The Mystical Diamond Unicorn" by the Franklin Mint. This beautiful 8 1/8-inch plate is bordered insilver, individually hand numbered, in excellent condition and comes with the original Certificate of Authenticity.
As you can see in the photo this plate is very distinctive with a bright, sharp image of anunicornwith a sparkling little gem against avibrantbackground makingit a very nice gift choice or a perfect addition to your own collection.
Shipping and handling will be via Priority Mail with Delivery Confirmation. I'm always happy to offer a combined shipping discounton multiple purchases for anyone interested in any of the other collectibles I have listed.
Thank you so much for looking, and I invite you to check my other listings as well - the Dancing Women and Earth earrings are my long time personal favorites.
Import duties, taxes and charges are not included in the item price or shipping charges. These charges are the buyer's responsibility.
Please check with your country's customs office to determine what these additional costs will be prior to offerding/buying."
These charges are normally collected by the delivering freight (shipping) company or when you pick the item up – do not confuse them for additional shipping charges.
We do not mark merchandise values below value or mark items as 'gifts' - US and International government regulations prohibit such actions.
This item has been shown times.
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Gamebirds Franklin Collectible Plate, Ptarmigan, Birds, P84
Gamebirds Franklin Collectible Plate,common Snipe,birds, P81
Majestic Eagle -power And Majesty- Franklin Mint Collection Ltd Ed Bird Plate
Holy Cats - Franklin Mint Collector Bill Bell Collectible Plate P17 Yy
Jaguar, Night Stalker - Franklin Mint Collector Plate Wild Cat P9 Yy
The Life Of Christ, Franklin Mint Heirloom Recommendation Limited Edition Plate


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Events for November 13, 2013
International Festival of Authors at Harbourfront Centre
When: From 10/24/2013 to 11/13/2013
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The Real Estate Talk Show gang capturing a great moment with Neil LaBatte.Read More
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RT @OliverBonacini: .@America_Toronto will be offering Easter brunch on Sun w/ made-to-order omelettes, oysters, prime rib & more. Menu: ht…Read More
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Trump Suite 3506Read More
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Online Sale Alert! Up to 40% Off at Saks
by Fashion
Like us on Facebook
Saks just added new styles to their sale and I'm jumping on it! I know it can get a little daunting when there are so many items to look through but you can use their handy search box and sort by price (I use the low to high option). That way, you can find the best deals — pretty cool, huh? This Marc by Marc Jacobs Zigzag Stripe Top ($118, originally $198), would go perfectly with my high-waisted flared jeans . . .
Marc by Marc Jacobs
Marc Jacobs
j2e1n9 6 years
$118, wow that's a steal :OY: ;) I do love saks tho.
Myo 6 years
I 2nd that emalove ~ in fact I loved it so much I just bought it! (lol) I can totally see rockin it with my Anlo high-waist jeans! YIPPEEE!!! xx
gabiushka 6 years
I never shop at Saks
gabiushka 6 years
I never shop at Saks
emalove 6 years
I love that top!
aimeeb 6 years
I would never pay $118 for that top.
Link Love
- Meet Cara's Insta-twin, Olivia Herdt — Lucky
- 19 ways to dress like a New York City gal — Who What Wear
- And Kanye West's latest fashion venture is . . . — Racked
- This video forces you to think about diversity in fashion — HuffPost Style
- Buy Stuart Weitzman heels, fight cancer. It's a win-win — The Cut
- Avoid all wardrobe mishaps with these essentials — InStyle
- A stylish belt to DIY — and it won't break the bank — Man Repeller
- Are live-stream cameras about to change Fashion Week? — Style.com
- The new ring we can't stop obsessing over — SheFinds


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Oppose Obama's Abortion Pill Mandate
The ACLJ has recently filed a third lawsuit against President Obama's abortion-pill mandate. The mandate, implemented by the Department of Health and Human Services (HHS) through ObamaCare, forces employer provided health insurance plans to cover abortion pills. It forces people of faith who believe in the sanctity of human life to pay for abortion-pill coverage in direct violation of their constitutionally protected religious liberties.
The: ACLJ: has now filed three directed challenges to this unconstitutional regulation in federal courts around the country. We are representing Catholic and Evangelical Christian business owners alike who aim to conduct their businesses in accordance with their faith. The lawsuit argues that the HHS mandate violates the First Amendment, the Religious Freedom Restoration Act, and the Administrative Procedure Act.
We argue that these Christian business owners "are confronted with choosing between complying with its requirements in violation of their religious beliefs, or paying ruinous fines that would have a crippling impact on their ability to survive economically." The suit also argues that the abortion-pill mandate forces them to "provide their employees with coverage of those services that Plaintiffs consider immoral on religious grounds." The fact of the matter is no American should be forced to violate his or her faith by being required to pay for abortion-pill coverage. This strikes at the heart of the Constitution, the Bill of Rights, and the intent of our Founders.
The abortion-pill mandate is one of the greatest and most blatant attacks on religious liberty in America we have ever seen, and the: ACLJ: will continue to aggressively fight back in the courts and on Capitol Hill to see this unconstitutional violation of our liberty ended.
Jay Sekulow: is Chief Counsel of the ACLJ.
Also see...
Making a man believe that his child doesn't exist for decades is an unusually cruel thing to do. But for Tony Trapani, a secret letter he found after his wife...Read More
Jay Sekulow
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Russian President Vladimir Putin is normally trolling the global media at this time of year by posing shirtless and engaging


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Be warned this is horribly addictive plus you can rewind the footage to catch up on the little tikes – the ginger one is so naughty!
Kitten Cam17 Nov
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