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Part Time Jobs in Springfield, Virginia ( VA )
If you're looking for part time jobs, student jobs or jobs for teens in Springfield, Virginia, you've come to the right place! Chances are that GrooveJob.com has the right job for you and wants to be your only source for finding part time jobs in Springfield, Virginia.
We've got plenty of part time and summer jobs in Springfield, Virginia. Check out the list of employers below who are accepting applications for part time jobs in your town. Remember to check back with Groovejob.com on a regular basis. We add new part time job listings to our database every week, so you'll find new opportunities every time you check back with us.
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Part time nanny needed for 3 1/2 yr. old
I work part time and need someone to help with my daughter during the week and occasionally on weekends. I need someone who is...
Springfield, VA
Mother's Helper
We are in need of a part time babysitter/nanny starting In April, to assist me week day afternoons with infant twins. We're looking for...
Springfield, VA
Restaurant Manager - Springfield, VA ($50,000 - $55,000)
Job Snapshot Hiring Company: Gecko Employee Type: Full- time / Part - time Location: Springfield, VA Job Type: Skilled Industrial Salary:...
Springfield, VA
2-3 Days A Week, 7ish To 5:30ish. No Weekends
i have 2 little girls that need part time care a couple days a week while i am at work. preferrably at your home, as i just recently...
Springfield, VA
Merchandising Manager - Fashion Industry Opportunity
…must punch in and out through the time clock to record all time worked, follow hourly meal/break guidelines, and partner...
Springfield, VA
Hardlines Merchandiser job in
Requisition ID: 447901BR Job Function: Customer Service Employment Category: Regular Part - time State: Virginia (VA) State or...
Springfield, VA
Loss Prevention Associate job in
…ID: 447916BR Job Function: Asset Protection/Loss Prevention Employment Category: Regular Part - time State: Virginia (VA) State or...
Springfield, VA
Back Room Locator Specialist job in
Requisition ID: 443258BR Job Function: Sales Support Employment Category: Regular Part - time State: Virginia (VA) State or...
Springfield, VA
Service Desk Associate job in
Requisition ID: 442993BR Job Function: Customer Service Employment Category: Regular Part - time State: Virginia (VA) State or...
Springfield, VA
AVON Independent Sales Representative
AVON Independent Sales Representative Location: Work from home; Work online; Part - time or Full Time Opportunity : At a time when...
Springfield, VA
Human Services Specialist ( Part Time /On Call)
…Date/ Time : Thu. 04/02/15 11:59 PM Eastern Time Salary: $17.16 - $27.89 Hourly Job Type: Part Time /On Call Location: 2100...
Arlington, VA
Home Workers Wanted: Part Time /Full Time (Data Entry, Work From Home Positions)
…are dependable and looking to make as much as $350-$1,200 per week, or more working part time or full time . You work on your own...
Springfield, VA
Part - time Latin Teacher
Sidwell Friends, a coeducational Quaker day school located in Washington, DC, seeks a part - time Latin teacher for its Upper School...
Washington, DC
Assistant Manager Store\Kiosk Alexandria VA (Mt. Vernon)
…with management of the store, customer coordination, the welcome and wait time process, supporting the team and assisting sales...
Alexandria, VA
Bookseller, Part - Time
Bookseller, Part - Time Job Classification: Part Time Store Location: VA - Annandale - Northern Virginia Community College -...
Annandale, VA
Part - Time Nanny
…and a bubbly 4 year old daughter. We are two very busy professionals and looking for part - time help to give us breathing room. Our...
Alexandria, VA
Need Part - time help on Tuesday, March 31
…We are going on vacation starting on Wednesday. I took the day off on Tuesday but something came up at work and I am looking for someone...
Alexandria, VA
Hourly Shift Coordinator
…As a leader, you are expected to help guide, motivate, and mentor others in the restaurant, while also developing your management skills...
Alexandria, VA
Picker / Packer - Warehouse Workers (Full- time / Part - Time )
Looking for new team members to pick and pack in our distribution warehouse. We have both full- time and part - time positions available...
Alexandria, VA
Part - Time Full Service Associate
Looking for a Part - Time Full Service Associate to help in one of our retail stores. Must be outstanding in customer service and a...
Alexandria, VA
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This feature lists your most prevalent gear bonuses. You may select a bonus to see which items provide that bonus.
Strength: 77
Primary attribute for Barbarians and Crusaders.
Increases all damage for Barbarians and Crusaders by 77.00%.
Increases Armor by 77.
Dexterity: 77
Primary attribute for Demon Hunters and Monks.
Increases all damage for Demon Hunters and Monks by 77.00%.
Increases Armor by 7.70%.
Intelligence: 8240
Primary attribute for Witch Doctors and Wizards.
Increases all damage for Witch Doctors and Wizards by 8240.00%.
Increases resistances by 824.0.
Vitality: 4163
Increases Life, allowing more damage to be taken before dying.
Each point of Vitality increases Life by 100.
Armor: 5747
Reduces all damage from enemies of the same level as you by 0.00%.
Damage: 857068.00
The amount of damage per second you can deal.
Damage is based on your weapons, attributes, attack speed, Critical Hit Chance,
Critical Hit Damage, passive skills, and dual-wielding attack speed increase.
Toughness: 7968130
The total amount of raw damage you can take.
Toughness is based on your maximum Life, armor, dodge chance,
average resistances, and missile, melee, and elite damage reduction.
Recovery: 521455
The amount of Toughness you can recover every second in combat.
Recovery is based on your Toughness and Healing.
Healing: Life healed per Second.
Healing is based on your Life per Hit, Life per Second, Life Steal, Life per
Fury/Spirit/Wrath Spent, Life per Kill, and Health Globe Healing Bonus.
Maximum Life: 466610
If you lose all your Life, you die.
Life can be increased by skills, items, and Vitality.
Mana 870/870
The Witch Doctor uses Mana to cast
most spells. The Mana pool grows as the
Witch Doctor gains levels.
|Powered Armor
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|Crippling Shot
|Dirty Fighting
|Powered Shot
Last updated on Feb 2, 2015 2:14 PM PST

subset: commoncrawl


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Is Brewers Yeast Good For Dogs?
Who Knew? Uncommon Uses For Bananas!
6 Makeup Mistakes You May Be Making & How To Fix Them
This faucet that makes water look like latticework has ruined us for other sinks
Thrifty Chic: Copy Kim K's Fashion Week Look For Less
Perfect Hairstyles for 4c Natural Brides
Has "Love & Hip Hop's" Emily B. Gone Too Far?
The 13 Best Music Festivals in America
Finally Anne Hathaway's Wedding Pics Revealed
Benefits of Peppermint Oil for Natural Hair
Bleu Cheese and Herb Stuffed Cherry Tomatoes
Score Kerry Washington's Oscar Look For Less
Protein Packed Kale and White Bean Salad
Their Lips are Sealed: 5 Celebrity Couples That Kept a Secret
Cats That Look Like Pinup Girls
Porsha And Kordell Stewart's Over-the-Top Wedding
Working Through Your First Trimester: Do or Don't?
20 Decadent Bite-Sized Desserts
How To Spot A Man Who Only Wants One Thing!
Kevin Bacon Married His Cousin?
The Sexiest Celebrity Butts
7 Perfect (And Inexpensive) Spring Break Staycations
Top 10 Most Iconic Wedding Dresses
14 Celebrity Boyfriend Types You Wish You Had
Style Snag: Can You Interview in 4" Heels?
You Can Totally Afford Kate Middleton's Latest Outfit
The Perfect Half Up Hairstyle: A Kate Middleton Hair Tutorial
Which Atlanta Housewife is Losing Her Home?
6 Super Cheap Exotic Vacations that are Super Dreamy
Now Trending: Wide Leg Jeans and Bell Bottoms Are Back!


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Spring or not, water limits still in effect
Spring planting season may be here, but Clinton residents remain under a stiff no-outside-watering policy that was adopted last fall.
Spring planting season may be here, but Clinton residents remain under a stiff no-outside-watering policy that was adopted last fall.
Oil and gas leasing has basically stopped in this area for the moment, Clinton attorney Mart Tisdal told the approximately 100 people who attended last week's Oklahoma Mineral Owners Association me
Clinton police believe they have solved some major residential thefts in the north part of town, thanks to work by a number of officers and information from citizens.
Earthquakes were a recurring topic at Saturday's state meeting of the Oklahoma Mineral Owners Association held at the Frisco Center in Clinton.
Eight months and 12 days after entering the Cleveland Clinic in Cleveland, Ohio, C.B. Graft came home Thursday to cheers and waves from well-wishers lining the road to his west Clinton home.
During her presentation recently to members of the Custer County TRIAD, Clinton Regional Hospital Director of Volunteers Debbie Matz dispelled preconceived notions about the hospital's Lifeline pro
It appears that at least 40 households in Custer County will soon receive monetary help to put in new tornado saferooms, Emergency Management Director Mike Galloway said this week.
Custer County voters will be busy April 7 with special elections in communities across the county, Custer County Election Board Secretary Ann Brown said.
While not giving up on the idea, Custer County commissioners appear to have softened slightly their position on asking voters to extend the half-cent jail sales tax and convert it to roads and brid
Clinton is truly becoming a tourist destination city as up to 1,000 people a day have been flocking into Clinton's Water-Zoo indoor water park as Spring Break has geared up.
A New Mexico law firm has submitted a $25-million claim to Custer County and the State of Oklahoma on behalf of the estate of Mah-hi-vist Goodblanket and his parents, Wilbur and Melissa Goodblanket
Custer County is now free of the $10-million judgment it was assessed four years ago because of the misdeeds of former sheriff Mike Burgess.
A poster depicting all the Presidents of the United States who were wrestlers adorns the office window of head coach Shawn Finch, where it faces the Clinton High wrestling room for all his grappler
Clinton High School Legal Teams have kicked off their season with scrimmages against other schools, teacher coach Kathy Kelley said.
Arapaho-Butler basketball teams weren't the only residents of their towns who had a busy weekend;
522 Avant Avenue
Clinton, OK 73601
Phone: 580-323-5151
Fax: 580-323-5154


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Advertising Collectibles :1. American Express , 2000 , The American Express Appointment Book , Millennium Edition , Never Used2. Revlon , Tester Bottle , Jontue Body Silk , Used for Display Purposes3. Garden State Race Track , Cherry Hill NJ , Sport Glass , 4 x 30mm , Tele ...
Mar 23 -
Philadelphia :
Voorhees - Everything else
This Lalique Compiegne Jardiniere is a beautifully crafted bowl featuring hand-etched leaves of clear and frosted crystal.
If you were to purchase this item new from Lalique, the price would be in excess of $1100
This bowl has been well kept, has spent its time behind ...
Mar 22 -
Central NJ :
Marlton - Everything else
Let's Talk Deal-- I want to add more to this Deal, You can Take all of what you want or Just pick through Items All for ONE Low Price.
Large Inventory of Items and Rather Than Post Individually.. Will Take any reasonable Offer.. ( $2,000 is our estimate But Lets Talk) There ...
Mar 14 -
Pittsburgh :
Fairmont - Business & industrial
8 multi-rose columns, and 3 additional humped flat jelly roll netted rose garlands that can be made into a circle for table décor for a food table, or laid flat on the edge of a stage. In these pictures, it has been put to line a walkway at a bridal show, with the ...
Feb 16 -
Virginia Beach :
Virginia Beach - Everything else
Plexi Glass , Business Card Drop Box , With Display Back , Box approx. 6 1/2" x 5" x 3 1/2" ,Display Back approx 10 1/2" High . Mint Condition , Many Uses
Feb 9 -
Philadelphia :
Voorhees - Everything else
this unit used in seafood market and is only 5 years old// bought new for $10,500 works perfectly
Feb 8 -
Atlantic City :
Hammonton - Business & industrial
Brand new, but last year's inventory. Some of these are one of a kind, and when they are gone, they are gone. With tax, they are $5.25 each.
If you need a color scheme I don't have, and I have to make it up, it is $6 each for the pillows and moneybags, and $8 for ...
Feb 7 -
Virginia Beach :
Virginia Beach - Everything else
SunScape SS755
The SunScape SS755 is a true 200 watt system with shoulder tanners, 5 facial lamps (with intensity adjustments) and frosted acrylics.
It is considered a ...
Feb 6 -
Charlotte :
Harrisburg - Health & beauty
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I need multiple copies of R2-D2's with silver top (first version appeared in many old sets). They must be in excellent condition with no visual flaw). I am willing to pay $4 a piece. I live in USA. Pm me if you have some for sale.
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From Wikipedia, the free encyclopedia - View original article
|Insulin resistance
|Classification and external resources
|Insulin resistance
|Classification and external resources
Insulin resistance (IR) is a physiological condition in which cells fail to respond to the normal actions of the hormone insulin. The body produces insulin, but the cells in the body become resistant to insulin and are unable to use it as effectively, leading to hyperglycemia. Beta cells in the pancreas subsequently increase their production of insulin, further contributing to hyperinsulinemia. This often remains undetected and can contribute to a diagnosis of Type 2 Diabetes or latent autoimmune diabetes of adults.[1]
One of insulin's functions is to regulate delivery of glucose into cells to provide them with energy.[2] Insulin resistant cells cannot take in glucose, amino acids and fatty acids. Thus, glucose, fatty acids and amino acids 'leak' out of the cells. A decrease in insulin/glucagon ratio inhibits glycolysis which in turn decreases energy production. The resulting increase in blood glucose may raise levels outside the normal range and cause adverse health effects, depending on dietary conditions.[3] Certain cell types such as fat and muscle cells require insulin to absorb glucose. When these cells fail to respond adequately to circulating insulin, blood glucose levels rise. The liver helps regulate glucose levels by reducing its secretion of glucose in the presence of insulin. This normal reduction in the liver's glucose production may not occur in people with insulin resistance.[4]
Insulin resistance in muscle and fat cells reduces glucose uptake (and also local storage of glucose as glycogen and triglycerides, respectively), whereas insulin resistance in liver cells results in reduced glycogen synthesis and storage and also a failure to suppress glucose production and release into the blood. Insulin resistance normally refers to reduced glucose-lowering effects of insulin. However, other functions of insulin can also be affected. For example, insulin resistance in fat cells reduces the normal effects of insulin on lipids and results in reduced uptake of circulating lipids and increased hydrolysis of stored triglycerides. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Elevated blood fatty-acid concentrations (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic syndrome. If insulin resistance exists, more insulin needs to be secreted by the pancreas. If this compensatory increase does not occur, blood glucose concentrations increase and type 2 diabetes or latent autoimmune diabetes of adults occurs.[3][5]
|This section possibly contains original research. (October 2010)
These depend on poorly understood variations in individual biology and consequently may not be found with all people diagnosed with insulin resistance.[6]
Several associated risk factors include the following:
|This section needs additional citations for verification. (December 2011)
It is well known that insulin resistance commonly coexists with obesity. However, causal links between insulin resistance, obesity, and dietary factors are complex and controversial. It is possible that one of them arises first, and tends to cause the other; or that insulin resistance and excess body weight might arise independently as a consequence of a third factor, but end up reinforcing each other. Some population groups might be genetically predisposed to one or the other.[citation needed]
Dietary fat has long been implicated as a driver of insulin resistance. Studies on animals have observed significant insulin resistance in rats after just 3 weeks on a high-fat diet (59% fat, 20% carb.)[11] Large quantities of saturated, monounsaturated, and polyunsaturated (omega-6) fats all appear to be harmful to rats to some degree, compared to large amounts of starch, but saturated fat appears to be the most effective at producing IR.[12] This is partly caused by direct effects of a high-fat diet on blood markers, but, more significantly, ad libitum high-fat diet has the tendency to result in caloric intake that's far in excess of animals' energy needs, resulting in rapid weight gain. In humans, statistical evidence is more equivocal. Being insensitive to insulin is still positively correlated with fat intake, and negatively correlated with dietary fiber intake,[13] but both these factors are also correlated with excess body weight.
The effect of dietary fat is largely or completely overridden if the high-fat diet is modified to contain nontrivial quantities (in excess of 5–10% of total fat intake) of polyunsaturated omega-3 fatty acids.[12][14][15] This protective effect is most established with regard to the so-called "marine long-chain omega-3 fatty acids", EPA and DHA, found in algal, krill and fish oil; evidence in favor of other omega-3 fatty acids, in particular, the most common vegetable-based omega-3 fatty acid, ALA, also exists,[16] but it is more limited; some studies find ALA effective only among people with insufficient long-chain omega-3 intake,[17] and some studies fail to find any effect at all [18] (ALA may be converted partially into EPA and DHA by the human body, but the conversion rate is thought to be 10% or less, depending on diet and gender). The effect is thought to explain relatively low incidence of IR, type 2 diabetes, and obesity in polar foragers such as Alaskan Eskimos consuming their ancestral diet (which is very high in fat, but contains substantial amounts of omega-3),[19][20] however, it is not strong enough to prevent IR in the typical modern Western diet. Unlike their omega-6 counterparts (which may be produced cheaply from a variety of sources, such as corn and soybeans), major sources of omega-3 fatty acids remain relatively rare and expensive. Consequently, the recommended average intake of omega-3 for adult men in the United States is only 1.6 grams/day, or less than 2% of total fat; currently, the average consumption of omega-3 in the United States is approximately 1.3 grams/day, almost all of it in the form of ALA; EPA and DHA contributed less than 0.1 grams/day.[21]
Elevated levels of free fatty acids and triglycerides in the blood stream and tissues have been found in many studies to contribute to diminished insulin sensitivity.[12][22][23][24] Triglyceride levels are driven by a variety of dietary factors. They are correlated with excess body weight.[25] They tend to rise due to overeating and fall during fat loss.[26] At constant energy intake, triglyceride levels are correlated positively with trans fat intake and strongly inversely-correlated with omega-3 intake. High-carbohydrate, low-fat diets were found by many studies to result in elevated triglycerides,[27] in part due to higher production of VLDL from fructose and sucrose, and in part because increased carbohydrate intake tends to displace some omega-3 fatty acids from the diet.
Several recent authors suggested that the intake of simple sugars, and particularly fructose, is also a factor that contributes to insulin resistance.[28][29] Fructose is metabolized by the liver into triglycerides, and, as mentioned above, tends to raise their levels in the blood stream. Therefore, it may contribute to insulin resistance through the same mechanisms as the dietary fat. Just like fat, high levels of fructose and/or sucrose induce insulin resistance in rats,[30][31] and, just as with fat, this insulin resistance is ameliorated by fish oil supplementation.[32] One study observed that a low-fat diet high in simple sugars (but not in complex carbohydrates and starches) significantly stimulates fatty acid synthesis, primarily of the saturated fatty acid palmitate, therefore, paradoxically, resulting in the plasma fatty acid pattern that is similar to that produced by a high-saturated-fat diet.[33] It should be pointed out that virtually all evidence of deleterious effects of simple sugars so far is limited to their concentrated formulations and sweetened beverages. In particular, very little is known about effects of simple sugars in whole fruit and vegetables. If anything, epidemiological studies suggest that their high consumption is associated with somewhat lower risk of IR and/or metabolic syndrome.[34][35]
Yet another proposed mechanism involves the phenomenon known as leptin resistance. Leptin is a hormone that regulates long-term energy balance in many mammals. An important role of leptin is long-term inhibition of appetite in response to formation of body fat. This mechanism is known to be disrupted in many obese individuals: even though their leptin levels are commonly elevated, this does not result in reduction of appetite and caloric intake.[36] Leptin resistance may be triggered in rats by ad libitum consumption of energy-dense, highly-palatable foods over a period of several days.[37] Chronic consumption of fructose in rats ultimately results in leptin resistance (however, this has only been demonstrated in a diet where fructose provided 60% of calories;[38] consumption by humans in a typical Western diet is several times lower.) Once leptin signalling has been disrupted, the individual becomes prone to further overeating, weight gain, and insulin resistance.
As elevated blood glucose levels are the primary stimulus for insulin secretion and production, habitually excessive carbohydrate intake is another likely contributor. This serves as a major motivation behind the low-carb family of diets. Furthermore, carbohydrates are not equally absorbed (for example, the blood glucose level response to a fixed quantity of carbohydrates in baked potatoes is about twice the response to the same quantity of carbohydrates in pumpernickel bread). Integrated blood glucose response to a fixed quantity of carbohydrates in a meal is known as glycemic index (GI). Some diets are based on this concept, assuming that consumption of low-GI food is less likely to result in insulin resistance and obesity, however, small to moderate amounts of simple sugars (i.e., sucrose, fructose, and glucose) in the typical developed-world diet seem to not have a causative effect on the development of insulin resistance.[39]
Once established, insulin resistance would result in increased circulating levels of insulin. Since insulin is the primary hormonal signal for energy storage into fat cells, which tend to retain their sensitivity in the face of hepatic and skeletal muscle resistance, IR stimulates the formation of new fatty tissue and accelerates weight gain.[40]
Another possible explanation is that both insulin resistance and obesity often have the same cause, systematic overeating, which has the potential to lead to insulin resistance and obesity due to repeated administration of excess levels of glucose, which stimulate insulin secretion; excess levels of fructose, which raise triglyceride levels in the bloodstream; and fats, which may be absorbed easily by the adipose cells, and tend to end up as fatty tissue in a hypercaloric diet. Some scholars go as far as to claim that neither insulin resistance, nor obesity really are metabolic disorders per se, but simply adaptive responses to sustained caloric surplus, intended to protect bodily organs from lipotoxicity (unsafe levels of lipids in the bloodstream and tissues): "Obesity should therefore not be regarded as a pathology or disease, but rather as the normal, physiologic response to sustained caloric surplus… As a consequence of the high level of lipid accumulation in insulin target tissues including skeletal muscle and liver, it has been suggested that exclusion of glucose from lipid-laden cells is a compensatory defense against further accumulation of lipogenic substrate."[41]
Fast food meals typically possess several characteristics, all of which have independently been linked to IR: they are energy-dense, palatable, and cheap, increasing risk of overeating and leptin resistance; simultaneously, they are high in dietary fat and fructose, and low in omega-3; and they usually have high glycemic indices. Consumption of fast food has been proposed as a fundamental factor behind the metabolic syndrome epidemic and all its constituents.[40]
An American study has shown that glucosamine (often prescribed for joint problems) may cause insulin resistance.[42] Other studies, however, could not confirm a significant effect on blood glucose or insulin resistance.[43][44][45]
Studies show that high levels of cortisol within the bloodstream from the digestion of animal protein may contribute to the development of insulin resistance.[46][47] Additionally, animal protein, because of its high content of purine, causes blood pH to become acidic. Several studies conclude that high uric acid levels, apart from other contributing factors, by itself may be a significant cause of insulin resistance.[48]
Vitamin D deficiency also is associated with insulin resistance.[49]
Sedentary lifestyle increases the likelihood of development of insulin resistance.[50][51] It has been estimated that each 500 kcal/week increment in physical activity related energy expenditure, reduces the lifetime risk of type 2 diabetes by 6%.[52] A different study found that vigorous exercise at least once a week reduced the risk of type 2 diabetes in women by 33%.[53]
Protease inhibitors found in HIV drugs are linked to insulin resistance.[54]
At the cellular level, much of the variance in insulin sensitivity between untrained, non-diabetic humans may be explained by two mechanisms: differences in phospholipid profiles of skeletal muscle cell membranes, and in intramyocellular lipid (ICML) stores within these cells.[55] High levels of lipids in the bloodstream have the potential to result in accumulation of triglycerides and their derivatives within muscle cells, which activate proteins Kinase C-ε and C-θ, ultimately reducing the glucose uptake at any given level of insulin.[22][56] This mechanism is quite fast-acting and may induce insulin resistance within days or even hours in response to a large lipid influx.[57] Draining the intracellular reserves, on the other hand, is more challenging: moderate caloric restriction alone, even over a period of several months, appears to be ineffective,[58][59] and it must be combined with physical exercise to have any effect. A 2011 study found, however, that a severe ultra-low-calorie diet, limiting patients to 600 calories/day for a period of two months, without explicit exercise targets, was capable of reversing insulin resistance and type 2 diabetes.[60])
In the long term, diet has the potential to change the ratio of polyunsaturated to saturated phospholipids in cell membranes, correspondingly changing cell membrane fluidity; full impact of such changes is not fully understood, but it is known that the percentage of polyunsaturated phospholipids is strongly inversely-correlated with insulin resistance.[61] It is hypothesized that increasing cell membrane fluidity by increasing PUFA concentration might result in an enhanced number of insulin receptors, an increased affinity of insulin to its receptors, and a reduced insulin resistance, and vice versa.[62]
Many stressing factors may lead to increased cortisol in the bloodstream. Cortisol counteracts insulin, contributes to hyperglycemia-causing hepatic gluconeogenesis,[63] and inhibits the peripheral utilization of glucose, which eventually leads to insulin resistance.[63] It does this by decreasing the translocation of glucose transporters (especially GLUT4) to the cell membrane.[64][65]
Although inflammation often is caused by cortisol, inflammation by itself also seems to be implicated in causing insulin resistance. Mice without JNK1-signaling do not develop insulin resistance under dietary conditions that normally produce it.[66][67]
Rare type 2 diabetes cases sometimes use high levels of exogenous insulin. As short-term overdosing of insulin causes short-term insulin resistance, it has been hypothesized that chronic high dosing contributes to more permanent insulin resistance.[citation needed]
At a molecular level, insulin resistance has been proposed to be a reaction to excess nutrition by superoxide dismutase in cell mitochondria that acts as an antioxidant defense mechanism. This link seems to exist under diverse causes of insulin resistance. It also is based on the finding that insulin resistance may be reversed rapidly by exposing cells to mitochondrial uncouplers, electron transport chain inhibitors, or mitochondrial superoxide dismutase mimetics.[68]
Recent research and experimentation has uncovered a non-obesity related connection to insulin resistance and type 2 diabetes. It has long been observed that patients who have had some kinds of bariatric surgery have increased insulin sensitivity and even remission of type 2 diabetes. It was discovered that diabetic/insulin resistant non-obese rats whose duodenum has been removed surgically, also experienced increased insulin sensitivity and remission of type 2 diabetes. This suggested similar surgery in humans, and early reports in prominent medical journals (January 8) are, that the same effect is seen in humans, at least the small number who have participated in the experimental surgical program. The speculation is, that some substance is produced in that initial portion of the small intestine that signals body cells to become insulin resistant. If the producing tissue is removed, the signal ceases and body cells revert to normal insulin sensitivity. No such substance has been found as yet, so the existence of such a substance remains speculative.[citation needed]
Insulin resistance is associated with PCOS.[69]
Hepatitis C also makes people three to four times more likely to develop type 2 diabetes and insulin resistance.[9] In addition, "people with Hepatitis C who develop diabetes probably have susceptible insulin-producing cells, and probably would get it anyway, but much later in life.[9] The extra insulin resistance caused by Hepatitis C apparently brings on diabetes at age 35 or 40, instead of 65 or 70."[9]
Any food or drink containing glucose (or the digestible carbohydrates that contain it, such as sucrose, starch, etc.) causes blood glucose levels to increase. In normal metabolism, the elevated blood glucose level instructs beta (β) cells in the Islets of Langerhans, located in the pancreas, to release insulin into the blood. The insulin, in turn, makes insulin-sensitive tissues in the body (primarily skeletal muscle cells, adipose tissue, and liver) absorb glucose, and thereby lower the blood glucose level. The beta cells reduce insulin output as the blood glucose level falls, allowing blood glucose to settle at a constant of approximately 5 mmol/L (mM) (90 mg/dL). In an insulin-resistant person, normal levels of insulin do not have the same effect in controlling blood glucose levels. During the compensated phase on insulin resistance, insulin levels are higher, and blood glucose levels are still maintained. If compensatory insulin secretion fails, then either fasting (impaired fasting glucose) or postprandial (impaired glucose tolerance) glucose concentrations increase. Eventually, type 2 diabetes or latent autoimmune diabetes occurs when glucose levels become higher throughout the day as the resistance increases and compensatory insulin secretion fails. The elevated insulin levels also have additional effects (see insulin) that cause further abnormal biological effects throughout the body.[citation needed]
The most common type of insulin resistance is associated with overweight and obesity in a condition known as the metabolic syndrome. Insulin resistance often progresses to full Type 2 diabetes mellitus (T2DM) or latent autoimmune diabetes of adults.[70][71] This often is seen when hyperglycemia develops after a meal, when pancreatic β-cells are unable to produce sufficient insulin to maintain normal blood sugar levels (euglycemia) in the face of insulin resistance. The inability of the β-cells to produce sufficient insulin in a condition of hyperglycemia is what characterizes the transition from insulin resistance to T2DM.[72]
Various disease states make body tissues more resistant to the actions of insulin. Examples include infection (mediated by the cytokine TNFα) and acidosis. Recent research is investigating the roles of adipokines (the cytokines produced by adipose tissue) in insulin resistance. Certain drugs also may be associated with insulin resistance (e.g., glucocorticoids).[citation needed]
The presence of insulin leads to a kind of insulin resistance; every time a cell is exposed to insulin, the production of GLUT4 (type four glucose receptors) on the membrane of the cell decreases somewhat.[73] In the presence of a higher than usual level of insulin (generally caused by insulin resistance), this down-regulation acts as a kind of positive feedback, increasing the need for insulin. Exercise reverses this process in muscle tissue,[74] but if it is left unchecked, it may contribute to insulin resistance.
Elevated blood levels of glucose — regardless of cause — lead to increased glycation of proteins with changes, only a few of which are understood in any detail, in protein function throughout the body.[75][76]
Insulin resistance often is found in people with visceral adiposity (i.e., a high degree of fatty tissue within the abdomen — as distinct from subcutaneous adiposity or fat between the skin and the muscle wall, especially elsewhere on the body, such as hips or thighs), hypertension, hyperglycemia, and dyslipidemia involving elevated triglycerides, small dense low-density lipoprotein (sdLDL) particles, and decreased HDL cholesterol levels. With respect to visceral adiposity, a great deal of evidence suggests two strong links with insulin resistance. First, unlike subcutaneous adipose tissue, visceral adipose cells produce significant amounts of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-a), and Interleukins-1 and -6, etc. In numerous experimental models, these proinflammatory cytokines disrupt normal insulin action in fat and muscle cells, and may be a major factor in causing the whole-body insulin resistance observed in patients with visceral adiposity. Much of the attention on production of proinflammatory cytokines has focused on the IKK-beta/NF-kappa-B pathway, a protein network that enhances transcription of inflammatory markers and mediators that may cause insulin resistance. Second, visceral adiposity is related to an accumulation of fat in the liver, a condition known as non-alcoholic fatty liver disease (NAFLD). The result of NAFLD is an excessive release of free fatty acids into the bloodstream (due to increased lipolysis), and an increase in hepatic glycogenolysis and hepatic glucose production, both of which have the effect of exacerbating peripheral insulin resistance and increasing the likelihood of Type 2 diabetes mellitus.[citation needed]
Also, insulin resistance often is associated with a hypercoagulable state (impaired fibrinolysis) and increased inflammatory cytokine levels.[77]
A fasting serum insulin level greater than 25mIU/L or 174pmol/L are considered insulin resistance. Same levels applies for levels after 3 hours of last meal. .[78]
During a glucose tolerance test, which may be used to diagnose diabetes mellitus, a fasting patient takes a 75 gram oral dose of glucose. Then blood glucose levels are measured over the following two hours.
Interpretation is based on WHO guidelines. After two hours a glycemia less than 7.8 mmol/L (140 mg/dl) is considered normal, a glycemia of between 7.8 to 11.0 mmol/L (140 to 197 mg/dl) is considered as impaired glucose tolerance (IGT), and a glycemia of greater than or equal to 11.1 mmol/L (200 mg/dl) is considered diabetes mellitus.
An oral glucose tolerance test (OGTT) may be normal or mildly abnormal in simple insulin resistance. Often, there are raised glucose levels in the early measurements, reflecting the loss of a postprandial peak (after the meal) in insulin production. Extension of the testing (for several more hours) may reveal a hypoglycemic "dip," that is a result of an overshoot in insulin production after the failure of the physiologic postprandial insulin response.[citation needed]
The gold standard for investigating and quantifying insulin resistance is the "hyperinsulinemic euglycemic clamp," so-called because it measures the amount of glucose necessary to compensate for an increased insulin level without causing hypoglycemia.[79] It is a type of glucose clamp technique. The test rarely is performed in clinical care, but is used in medical research, for example, to assess the effects of different medications. The rate of glucose infusion commonly is referred to in diabetes literature as the GINF value.[80]
The procedure takes about two hours. Through a peripheral vein, insulin is infused at 10–120 mU per m2 per minute. In order to compensate for the insulin infusion, glucose 20% is infused to maintain blood sugar levels between 5 and 5.5 mmol/l. The rate of glucose infusion is determined by checking the blood sugar levels every five to ten minutes. Low-dose insulin infusions are more useful for assessing the response of the liver, whereas high-dose insulin infusions are useful for assessing peripheral (i.e., muscle and fat) insulin action.[80]
The rate of glucose infusion during the last thirty minutes of the test determines insulin sensitivity. If high levels (7.5 mg/min or higher) are required, the patient is insulin-sensitive. Very low levels (4.0 mg/min or lower) indicate that the body is resistant to insulin action. Levels between 4.0 and 7.5 mg/min are not definitive, and suggest "impaired glucose tolerance," an early sign of insulin resistance.[80]
This basic technique may be enhanced significantly by the use of glucose tracers. Glucose may be labeled with either stable or radioactive atoms. Commonly-used tracers are 3-3H glucose (radioactive), 6,6 2H-glucose (stable) and 1-13C Glucose (stable). Prior to beginning the hyperinsulinemic period, a 3h tracer infusion enables one to determine the basal rate of glucose production. During the clamp, the plasma tracer concentrations enable the calculation of whole-body insulin-stimulated glucose metabolism, as well as the production of glucose by the body (i.e., endogenous glucose production).[80]
Another measure of insulin resistance is the modified insulin suppression test developed by Gerald Reaven at Stanford University. The test correlates well with the euglycemic clamp, with less operator-dependent error. This test has been used to advance the large body of research relating to the metabolic syndrome.[80]
Patients initially receive 25 mcg of octreotide (Sandostatin) in 5 ml of normal saline over 3 to 5 minutes via intravenous infusion (IV) as an initial bolus, and then, are infused continuously with an intravenous infusion of somatostatin (0.27 μgm/m2/min) to suppress endogenous insulin and glucose secretion. Next, insulin and 20% glucose is infused at rates of 32 and 267 mg/m2/min, respectively. Blood glucose is checked at zero, 30, 60, 90, and 120 minutes, and thereafter, every 10 minutes for the last half-hour of the test. These last four values are averaged to determine the steady-state plasma glucose level (SSPG). Subjects with an SSPG greater than 150 mg/dl are considered to be insulin-resistant.[80]
Given the complicated nature of the "clamp" technique (and the potential dangers of hypoglycemia in some patients), alternatives have been sought to simplify the measurement of insulin resistance. The first was the Homeostatic Model Assessment (HOMA), and a more recent method is the Quantitative insulin sensitivity check index (QUICKI). Both employ fasting insulin and glucose levels to calculate insulin resistance, and both correlate reasonably with the results of clamping studies. Wallace et al. point out that QUICKI is the logarithm of the value from one of the HOMA equations.[81]
The primary treatment for insulin resistance is exercise and weight loss. Research shows that a low-carbohydrate diet may help.[82] Both metformin, and thiazolidinediones improve insulin resistance, but only are approved therapies for type 2 diabetes, not for insulin resistance. By contrast, growth hormone replacement therapy may be associated with increased insulin resistance.[83]
Metformin has become one of the more commonly prescribed medications for insulin resistance.
The Diabetes Prevention Program showed that exercise and diet were nearly twice as effective as metformin at reducing the risk of progressing to type 2 diabetes.[84] One 2009 study found that carbohydrate deficit after exercise, but not energy deficit, contributed to insulin sensitivity increase.[85]
Resistant starch from high-amylose corn, amylomaize, has been shown to reduce insulin resistance in healthy individuals, and in individuals with type 2 diabetes.[86][87][88][89][90][91] Animal studies demonstrate that it cannot reverse insulin resistance, but that it reduces the development of insulin resistance.[92][93][94]
Some types of monounsaturated fatty acids, saturated, and trans fats promote insulin resistance. Some types of polyunsaturated fatty acids (omega-3) may moderate the progression of insulin resistance into type 2 diabetes,[95][96][97] however, omega-3 fatty acids appear to have limited ability to reverse insulin resistance, and they cease to be efficacious once type 2 diabetes is established.[98]
Caffeine intake limits insulin action, but not enough to increase blood-sugar levels in healthy persons. People who already have type 2 diabetes may see a small increase in levels if they take 2 or 21/2 cups of coffee per day.[99]
The concept that insulin resistance may be the underlying cause of diabetes mellitus type 2 was first advanced by Professor Wilhelm Falta and published in Vienna in 1931,[100] and confirmed as contributary by Sir Harold Percival Himsworth of the University College Hospital Medical Centre in London in 1936,[101] however, type 2 diabetes does not occur unless there is concurrent failure of compensatory insulin secretion.[102]
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text:
Trojan horse viruses send telephone bills soaring
They sneak into your computer and link you up to premium phone lines, warns James Daley
Saturday 23 October 2004
For the more than 30m people who have access to the internet at home in the UK, computer viruses are unlikely to be a stranger. As the number of web-users has continued to grow over the past few years, so too, sadly, has the number of people who devote their time to creating programmes that incapacitate, confuse or completely ruin your PC.
For the more than 30m people who have access to the internet at home in the UK, computer viruses are unlikely to be a stranger. As the number of web-users has continued to grow over the past few years, so too, sadly, has the number of people who devote their time to creating programmes that incapacitate, confuse or completely ruin your PC.
These can be a major inconvenience, but the latest breed of viruses is proving to be much more sinister, landing computer owners with hefty bills - often running into hundreds, or even thousands, of pounds.
These scams work like this. While you are browsing the web, a file will surreptitiously download itself onto your computer. Once it has installed itself, it will temporarily disconnect you from the internet and then redial, this time connecting you to a premium-rate number charged at £1.50 a minute. Once reconnected, you can often continue browsing as you were before - unaware that you are now paying a rate of £90 an hour.
The number of people affected by these so-called "Trojan horse" viruses has soared in recent months, with BT alone reporting in excess of 35,000 complaints. And for those who still pay their bills on a quarterly basis, it is often months until they realise the abnormally large charges being incurred.
In my case, it was a whopping £200 in three months, which I discovered only when I received a quarterly phone bill that was triple the normal size. In many other cases, the sums involved have been even greater.
The process of sorting out this mess is unfortunately not as simple as it should be. While "rogue diallers", as the industry refers to them, are illegal, many of the companies running these scams are based abroad, and can prove difficult to bring to justice. Your first port of call when you think you may have been a victim is to turn to Icstis, the body that regulates premium-rate numbers. Its website, www.icstis.org.uk, provides a free number-checking service which will allow you to identify the owner of the premium-rate numbers you have been calling, and to see whether Icstis is investigating them.
Once you have established who has been responsible for taking your money, you have to write a letter to the company, asking for a refund. The next stop is your phone provider. While most telephone companies, BT included, will allow you to defer payment in relation to these call charges, they will not allow you to forget about payment altogether.
Frustratingly, BT provides its customers with a glimmer of hope by saying they will not have to pay up while the offending party is being investigated. However, once the investigation is complete, it will demand payment, regardless of the outcome. Even if it is convinced you have been conned, it will give you a pat on the back, work towards ensuring that other customers are not ensnared, and ask you to cough up. If you want compensation, it says, you will have to get it from the premium-rate phone company.
Icstis is also rather toothless. In August, it took steps to ensure that all premium-rate dialler services would have to obtain a licence. Only this week, it said that it had banned 11 companies that had failed to apply for a licence.However, for those companies that have already managed to get away with the con for several months, Icstis's orders to pay fines and to refund customers can easily be ignored. With most offenders based in Europe, these companies know that there is a lot of paperwork needed for Icstis to get anywhere near them.
So far, the regulator has managed to fine and get customer refunds from eight companies. However, pinning down the rest is likely to be much trickier. In fairness to Icstis, its job is to regulate, not to prosecute for fraud. This, it says, is a matter for the police, and it insists that it is working alongside the high-tech crime unit.
Unfortunately, all this does not help those already struggling to pay huge phone bills. While the likes of BT say they cannot be held responsible for the levels of security that their customers have on their computers, it could be argued that they have a duty of care to inform customers when their bills become abnormally large.
With a little luck, the new measures being put in place by Icstis and Ofcom, the telephone regulator, will ensure that these scams are eliminated. But for those of us who have already been stung, the road to compensation may be long and tiresome.
* Get a good virus-checker. Some of the best virus software is available for as little as £20 over the internet - an invaluable investment if you are going to keep your computer clean. Make sure you keep it updated, as new viruses are constantly being created.
* Get broadband. Broadband internet connections do not allow this sort of virus. With broadband quickly falling in price, now may be the time to do away with your dial-up modem.
* Put a premium-rate block on your phone. This might be a problem if you like voting on Big Brother- type programmes, or entering TV competitions, but it will ensure that if you do contract a virus, it cannot make any costly premium-rate calls on your line.
* Get a pop-up blocker for your internet browser. Many of these viruses manifest themselves through internet pop-up screens. If you block pop-ups, you lessen the chances of being able to contract this sort of virus. Google offers a free downloadable pop-up blocker.
Independent Partners; Do you need financial advice on your investments, pension or insurance? Book a free consultation with an independent Financial Adviser at VouchedFor.co.uk
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Recent Exhibits
Once Upon a Canvas: Exploring Fairy Tale Illustrations from 1870-1942
A student-run exhibition of fairy tale illustrations from Tulane's Special Collections and from the Amoss Collection, Howard-Tilton Memorial Library; in conjunction with the course "GERM 3670: Grimm Reckonings, The Development of the German Fairy Tale," offered during the Spring semester 2013by the
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Early New Orleans Jazz Posters
The Early New Orleans Jazz Posters exhibit from the Hogan Jazz Archive offers a rare glimpse at music and society in New Orleans at the turn of the twentieth century. Through a series of posters advertising various social events, one can see firsthand the strong connection between the formation of Jazz and the Social
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Charlee LaChatte and Friends: Collecting Cats at Tulane
This exhibit is meant to explore and celebrate the cat collections at Tulane. While it may seem unusual to have such objects in university collections, it should not surprise us that artists and writers have responded to human interest in the subject. In the cases in this room you will find a selection of the books
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This online exhibit is sponsored by The Latin American Library (LAL) at Tulane University. In September 2013, Erika Diettes exhibited samples of her work in the LAL gallery in conjunction with the Library's annual Open House.
SHROUDS (Sudarios)is the result of multiple theoretical concerns, an infinity of technical
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People and Places
The photographs of Abbye A. Gorin 1937 to 2000
Music Illustrated: The Songbooks of the Original Dixieland Jazz Band
An exhibition featuring photographs of the Original Dixieland Jazz Band's songbooks and publications spanning the career of their founder and cornetist Dominic James "Nick" LaRocca.
The Free Southern Theater and the Black Arts Movement
Originating as a community theater group based in Jackson, Mississippi, in 1963, the Free Southern Theater (FST) became a cultural arm of the Civil Rights Movement. Upon moving to New Orleans in 1965, the FST became a major influence on Black Theater, both locally and nationally. As part of a community-wide celebration
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The Treasures of Tulane
Preserving Louisiana's Legacy
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Sole e Luna Bed & Breakfast Rooms & Accommodation
Situated in the heart of Rome, Sole e Luna Bed & Breakfast is within walking distance of Historic Museum of the Liberation and Basilica di San Giovanni in Laterano. Also nearby are Colosseum and Basilica di Santa Maria Maggiore.
Property Features.
Guests are served a complimentary breakfast each morning. In addition to tour/ticket assistance and room service (during limited hours), Sole e Luna Bed & Breakfast features an elevator (lift). Complimentary wireless Internet access is available in public areas. For a surcharge, guests receive transportation including a roundtrip airport shuttle at scheduled times and a cruise ship terminal shuttle. This is a smoke-free property.
The 10 guestrooms at Sole e Luna Bed & Breakfast include safes and hair dryers. Complimentary wireless high-speed Internet access is provided. Televisions are equipped with digital channels.
very helpful staff. easy access to trains/attractions. A little hard to find but good…
One of the worst hotel we have stayed at. I would not ever stay there again. Room was bad…
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Hotel Info: 0800 456 081from NZ$46
- Quadruple Room, Private Bathroom
- Double Room Single Use, Shared Bathroom
- Triple Room, Shared Bathroom
- Quadruple Room, Shared Bathroom
- Triple Room, Private Bathroom
- Double Room, Shared Bathroom
- Double Room, Private Bathroom
- Economy Double Room
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At a glance
Key facts
Hotel size
- This hotel has 10 rooms
- This hotel is arranged over 3 floors
- 24-hour check-in
- Check-out time is 10 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- No cribs (infant beds)
- No pets or service animals allowed
Extra people
- Rollaway beds available, charges may apply*
- Free WiFi in public areas
- Free WiFi in rooms
- Airport shuttle at scheduled times *
- Cruise terminal shuttle *
- No parking
Other information
- Smoke-free property
Nearby One Star Rome hotels
In the hotel
- Free breakfast daily
- Room service (during limited hours)
- Tours/ticket assistance
- Number of buildings/towers - 1
- Elevator/lift
In the room
- Egyptian-cotton sheets
- Private bathroom
- Shower only
- Hair dryer
- Digital TV channels
- Free WiFi
- In-room safe
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Sole e Luna Bed & Breakfast Rooms & Accommodation's small print
Cash transactions at this property cannot exceed EUR 999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation.
For transfers, guests must contact the property 48 hours prior to arrival at the number on the booking confirmation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 3.50 per person, per night, up to 10 nights. This tax does not apply to children under 10 years of age.
Optional extras
Rollaway beds are available for EUR 20 per day
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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- When Stacey Lee Harvey went for a walk near Iluka on the New South Wales north coast on the weekend, she thought she'd stumbled upon sharks caught in a rock pool at low tide. But after taking a closer look, she realised it was dozens of sting rays....Tuesday 19 November 2013
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Premier Inn London Docklands - Excel
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Really great hotel which is trendy and very clean. The bedroom was clean, spacious and modern. The s...
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Stayed at hotel for two nights. Great location , so many fantastic places to visit. Borough market i...
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GNOME Activity Journal Released w/ Zeitgeist Update
Published on 20 January 2010 07:03 PM EST
Written by
Michael Larabel
5 Comments
Back in December
Zeitgeist 0.3 was released
with many changes and its engine was even largely reworked. Since then there have been a few point releases as GNOME Zeitgeist is in the process of being stabilized for a Zeitgeist 0.4 release in time for GNOME 2.30. Yesterday afternoon Zeitgeist 0.3.2 was released to deliver on more stabilization work along with better support for GNOME's Activity Journal. The release announcement can be read on the
mailing list
Minutes after releasing Zeitgeist 0.3.2, Seif Lotfy continued with his typing by announcing the first development release of the GNOME Activity Journal. The GNOME Activity Journal has been in development for more than a year and is designed to be an "activity browser" for GNOME that is powered by Zeitgeist. The GNOME Activity Journal currently supports a layout for viewing items, pinning important items, a calendar slider for moving forwards and backwards in time, and preview tool-tips. This free software application also has experimental support for Tracker-based search.
While not complete in GNOME Activity Journal 0.3.2, being worked on is support for displaying the web browsing history too, search and interaction, a tagging system, a detailed single-day view showing relationships between files, and support for removing items from the journal.
The inaugural release announcement for GNOME Activity Journal is also available on the
GNOME mailing list
. Additional information on this project can be found on their
GNOME Live page
Look for more releases of Zeitgeist and GNOME Activity Journal prior to the release of
in March while they really should be polished and ready in time for
when it's
released in September of 2010
5 Comments
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Archive Page - 08/16/13 41 years, 2,180 covers and 55,278 stories from PEOPLE magazine's history for you to enjoy
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Our special coverage of the closest race for years
Explore the personal stories of Syrian refugees in Lebanon
05 Dec 2013 09:44 GMT
Indian-administered Kashmir is reeling under a fresh crisis. At least 250 hotels have been ordered shut for failing to comply with pollution control norms, throwing the popular winter sports season out of gear.
Commercial operations in 140 hotels in the provincial capital Srinagar, 90 in the tourist town of Gulmarg and 20 in Pahalgam have come to a halt as they have not installed the mandatory sewage treatment plants, said a report in The Hindu newspaper.
The Pollution control board (PCB) sealed the hotels following a court order during the course of hearing on the issue of implementing sewage treatment norms.
Live Box 2013927135832671882
The winter season in Kashmir is much awaited around the world as it is time for the sporting season. A three-day winter sports conclave is already on and concludes on Wednesday. Many more are scheduled in the days ahead.
The newspaper, quoting a prominent hotelier and a key member of the hotel's associations Faiz Ahmed Bakshi, said the dramatic closure of hotels in Srinagar, Gulmarg and Pahalgam over the last week has created a panic.
Tourists who were already in the hotels were dragged out, he said. Many have cancelled their bookings and are looking to go to neighbouring states like Himachal Pradesh where winter tourism is popular.
Under federal pollution control norms, only hotels with 20 or more rooms need to have a sewage treatment plant. In this conflict-hit state, the government relaxed the norms for hotels up to 35 rooms.
Court criticism
The High Court came down heavily on this concession with the result that those who were enjoying the benefits of the concession have now been told to implement the pollution controls norms or shut operations.
Among the hotels closed are those who were not eligible for the concession yet had not installed sewage treatment plants on their premises.
Those who favour the implementation of pollution control argue that when owners can spend a few millions on setting up the hotels, why can't they expend a small percentage of it for treating effluents.
Hotel owners meanwhile are planning to appeal to the court against the closure and say they are confident of getting justice done quickly, before the winter season runs out.
Kashmir, which is the bone of dispute between India and Pakistan has been wracked by heightened separatist violence since 1989. The levels of violence have dipped somewhat in recent years making it possible for civilian activity in the valley to resume.
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Research In Adolescent Addiction Supported By Early Stimulus Funding
Main Category: Alcohol / Addiction / Illegal Drugs Also Included In: Pediatrics / Children's Health ; Clinical Trials / Drug Trials Article Date: 10 Jun 2009 - 2:00 PDT A Brown University professor is among the first in the country to win a federal research grant funded by national economic stimulus efforts.Read more
#1 Jun 12, 2009
I can't wait to find out what they learn from the study. Addition in young people is the most devastating. I found this moving testimonial form one person who was addicted to drugs from a young age.-
#3 Feb 4, 2013
I have ordered prescription drugs (without a prescription) online from http://inhousegeneric.info about two years ago, and was pleased with the speed and quality of service.
I'm thinking of doing the same thing with my medication. The meds is expensive, but there is a generic version available overseas.
I love the idea of taking responsibility for my own health (or lack of health) and skipping the bureaucracy... to say nothing of having to drive to the doctor, wait in line, yet again, to get a prescription refilled.
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http://inhousegeneric.info very clear and informative site, simple ordering process and very fast delivery. All round excellent service - will use again.
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I have used http://qgeneric.info/#fezz for about 3 years and find their products to be reliable and speedily delivered. The Support team are very promt and helpful in solving any issues that arise,caused by my errors not the company's. I was a little sceptical initially about buying generic products rather than brand names. However, the Mens' Health products I have bought have been equally as efficatious as the brand names at a fraction of the cost.
#7 Aug 17, 2013
Naturally, I am skeptical of everything online. http://inhousegeneric.com is legitimate. I placed my first order for the smallest amount possible. It arrived sooner than expected. I didn't pay the extra money for speedy air mail. I placed another order that was much larger and it came right on time. I will definitely use this company again for even larger orders now that I trust them. They also give you discounts every time you place an order which is cool. One thing to keep in mind is if you place a larger order, they will send half in one shipment, and then the other half after that to avoid customs scrutinizing your package. I am very happy, I no longer need to pay tons of money to see a doctor and therapist (and have them tell me a bunch of stuff I already know) in order to get my medication.
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Cornish & Carey Forecast: 2013 is shaping up, but it's no 2012
- Nathan Donato-Weinstein
- Real Estate Reporter- Silicon Valley Business Journal
- Email | Twitter
2013 will be plenty good. But perhaps not quite as great as 2012.
That's according to brokerage Cornish & Carey Commercial Newmark Knight Frank, which presented its annual Real Estate Review & Forecast on Wednesday. The event drew heavy hitters from local government, real estate, finance and construction to the Santa Clara Convention Center to hear from the brokerage that has had a hand in some of the biggest deals of the recent cycle.
"2010 through 2012 have been great years, and we're optimistic about 2013," said Charles Seufferlein, the brokerage's president and CEO. "None of us believe it will be the same type of year as it was last year, but we are optimistic things are going to hold."
Indeed, the Valley's commercial real estate market continued to build strength in 2012, thanks mostly to the tech sector. Total vacancy for Class A office space dropped to 9.9 percent from 11.9 percent a year earlier.
A vacancy rate below 10 percent is "a magic number for many in the lending community, and indicative of why you're seeing some construction happening now," Phil Mahoney, an executive vice president for Cornish & Carey, told attendees as part of his presentation.
Mahoney said gross office absorption in 2012, while down slightly from 2011, remained strong at about 8.9 million square feet, with net absorption rising slightly from the prior year to about 2.82 million square feet. Class A office rents were up 5 percent and 17 percent on the R&D side.
Major lease transactions during the year included the LinkedIn campus in Sunnyvale at 587,362 square feet and Lab126/Amazon.com deal, also in Sunnyvale, which weighed in at 581,973 square feet. And the brokerage is currently tracking more than 12.6 million square feet of tenant demand.
Nathan Donato-Weinstein covers commercial real estate and transportation for the Silicon Valley Business Journal.
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所带标签: app X
How does your mobile app security budget compare? 社区博客
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J.Claussen 标签: ibm-event-connect social-business podcast interconnect askjim app digital-engagement 256 次访问
A What You Need To Know Special The IBM InterConnect Event Connect App The AskJim Podcast Providing answers to user questions about IBM Connections With IBM InterConnect 2015 coming up, now is the time to...由 J.Claussen 于 修改
Available NOW! The IBM Technical Support Mobile App for Android
AcdntlPoet 标签: ibm-esupport mobile_applications ibm-electronic-support app mobile rational-client-support rational 710 次访问
As a welcome to the new year, we've just released th IBM Technical Support mobile app for Android which is now available via Google Play ! You can use this mobile app to: Expedite troubleshooting by searching for, viewing, and...
Make an App for that with Bluemix
Make an App for that with Bluemix - Are the needs for new business apps outstripping your enterprise's ability to deliver? Is the business asking for: simple mobile apps based upon existing systems? Situational apps for their department? Simple B2B apps to...
Rock N' Roll with Bluemix, Cloudant and NodeExpress
Tinniam V Ganesh 标签: nodeexpres app cloudant nodejs cloudcomputing bluemix 15,237 次访问
In this post I create a cloud application that is based on Bluemix, Cloudant DB and NodeExpress. NodeExpress is used to perform DB operations on CloudantDB The code can be forked from Devops from bluemix-cloudant-exp . You can...
来自博客: The Tech Trek由 Tinniam V Ganesh 于 修改
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Anup M. More 标签: mobile app apps software development application 783 次访问
The article is presented by Vijay Web Solutions India Pvt. Ltd. , a fastest growing web and mobile application development company in India. The advent of smartphones and tablets explosively propelled the use of...
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This post gives the key steps to get going in building a Mobile Cloud application on IBM's Bluemix. This post focuses on using the Android Platform for building the application. IBM Bluemix'es mobile cloud application includes under its hood mobile...
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KimMesseri 标签: app ibm-innovate app-throwdown event innovate ibm-power-systems linux-on-power 1,879 次访问
Guest post by Rich Griffith Solution Sales Manager: Industry BUE, IBM Ecosystem Development IBM Sales & Distribution, Software Sales IBM Power Systems is putting data to work! On April 23, we introduced Power...
来自博客: The Invisible Thread由 KimMesseri 于 修改
ClickSoftware wins the App Throwdown at Impact 2014
Congratulations to ClickSoftware for winning the App Throwdown competition at Impact 2014! ClickSoftware extends over 100 Business Apps for the field service execution industry to IBM users through the IBM Worklight platform. With easy install and...


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Love the design, but what happened to the Gallifrey shirt like this? I was gonna buy one…
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