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Bob McDonnell
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On the 11th anniversary of the Sept. 11 attacks, numerous politicians are issuing statements about the tragic events of that day in 2001.
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Virginia Governor Bob McDonnell's speech kept with Tuesday night's convention theme, taunting President Barack Obama for his line in a speech delivered in Roanoke in July when, in making the point that government aids private business, he said, "if you've got a business, you didn't build that."
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Gov. Bob McDonnell said Monday he is requesting the assistance through the Federal Emergency Management Agency.
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Gov. Bob McDonnell is asking Virginia's public colleges and universities to limit tuition increases.
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Brief Timeline of Garden Sheds?
Garden sheds are a British institution and have been for many years. Even before the 2nd world war garden sheds were popular with the nation and many gardeners 'dug for victory' during that time. Since then garden sheds have played a large role in the hearts of the country and there are very few gardens which don't have a garden shed of some sort. Whether it's a small garden shed for our modern day houses or a large garden workshop for the more affluent homes you will find these sheds are very well used.
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Page 1
Prostaglandin D Synthase (?-Trace) in Meningeal
Masatou Kawashima, M.D., Satoshi O. Suzuki, M.D., Ph.D., Tetsumori Yamashima, M.D., Ph.D.,
Masashi Fukui, M.D., Ph.D., Toru Iwaki, M.D., Ph.D.
From the Departments of Neuropathology (MK, SOS, TI) and Neurosurgery (MK, MF), Neurological
Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; and the Department
of Neurosurgery, Kanazawa University, School of Medicine, Kanazawa, Japan (TY)
The level of prostaglandin D synthase (PGDS), a
major protein constituent of cerebrospinal fluid
(CSF), is altered in various brain diseases, including
meningitis. However, its role in the brain remains
unclear. PGDS is mainly synthesized in the arach-
noid cells, the choroid plexus and oligodendrocytes
in the central nervous system. Among brain tumors,
meningiomas showed intense immunoreactivity to
PGDS in the perinuclear region. Thus, PGDS has
been considered a specific cell marker of meningi-
oma. In this study, we examined 25 meningeal he-
tumors (64%) showed immunoreactivity for PGDS
in the perinuclear region. For comparison, 15 me-
ningiomas, 14 soft-tissue HPCs, 1 mesenchymal
chondrosarcoma, 3 choroid plexus papillomas, and
7 oligodendrogliomas were also examined. Menin-
in 13 cases (80%). Except for one case located at the
sacrum, none of the other soft-tissue HPCs showed
immunostaining for PGDS. Mesenchymal chondro-
sarcoma arises in the bones of the skull, and its
histological pattern resembles that of HPC; how-
ever, it showed no immunoreactivity for PGDS. Nei-
ther choroid plexus papillomas nor oligodendrogli-
omas were immunopositive for PGDS. These
findings suggest that meningeal HPCs may have a
unique molecular phenotype that is distinct from
HPCs may be more closely related to the arachnoid
KEY WORDS: Arachnoid cells, Immunohistochem-
istry, Meningial hemangiopericytoma, Meningi-
oma, Prostaglandin D synthase.
Mod Pathol 2001;14(3):197–201
Meningeal hemangiopericytoma (HPC), formerly
regarded as a variant of angioblastic meningioma,
represents an uncommon type of perivascular soft-
tissue tumor (1). In 1942, Stout and Murray (2)
identified a soft-tissue tumor located primarily in
the thigh, buttock, and retroperitoneum that
seemed to consist of proliferating pericytes and
called it a hemangiopericytoma. Begg and Garrett
(3) first reported a meningeal HPC in 1954. They
reviewed six angioblastic meningiomas from Cush-
ing's series and concluded that they were actually
HPCs arising from within the meninges. Today,
most pathologists are convinced that meningeal
HPC and soft-tissue HPC are similar (4). Therefore,
meningeal HPC is thought to be a pericytic tumor
andis classifiedasa
Prostaglandin D synthase (PGDS) [prostaglandin
H2D isomerase; (5Z,13E)-(15S)-9,11-epidioxy-15-
18.104.22.168] is a brain-specific glycoprotein that regu-
lates sleep through the synthesis of PGD2. PGDS is
a member of the lipocalin superfamily composed of
various secretory lipophilic ligand-carrier proteins
(5–7). PGDS and its mRNA are mainly synthesized
in the arachnoid cells, the choroid plexus, and oli-
godendrocytes in the central nervous system (8–
10). In brain tumors, only meningioma cells have
been proved to show intense immunoreactivity to
PGDS in the perinuclear region (10). PGDS has thus
been considered a specific cell marker of meningi-
oma. The present study presents an immunohisto-
chemical comparison of 25 meningeal HPCs, 15
meningiomas, 14 soft-tissue HPCs, 1 mesenchymal
chondrosarcoma, 3 choroid plexus papillomas
(CPPs), and 8 oligodendrogliomas with respect to
the brain-specific protein PGDS.
different entityfrom
Copyright © 2001 by The United States and Canadian Academy of
Pathology, Inc.
VOL. 14, NO. 3, P. 197, 2001 Printed in the U.S.A.
Date of acceptance: November 27, 2000.
Address reprint requests to: Masatou Kawashima, Department of Neuro-
pathology, Neurological Institute, Graduate School of Medical Sciences,
Kyushu University60, Fukuoka,
firstname.lastname@example.com; fax: ?81-92-642-5540.
812-8582,Japan; e-mail:
Page 2
The tumor samples listed in Table 1 were ob-
tained at surgery from 23 patients (17 male and 6
female, including two recurrent cases; ranging in
age from 13–66 y) at the Department of Neurosur-
gery, Kyushu University Hospital. The tumor sam-
ples listed in Tables 2–4 were also submitted at
surgery from 14 patients in Table 2 (8 male and 6
female; ranging in age from 0–65 y), 1 patient in
Table 3 (male; 12 years old) and 15 patients in Table
4 (4 male and 11 female; ranging in age from 41–83
y) at the Departments of Surgery, Orthopedics, and
Neurosurgery, Kyushu University Hospital. Three
CPPs (from one male and two female patients rang-
ing in age from 17–67 y) and seven oligodendrogli-
omas (from six male and one female patients rang-
ing in age from 31–69 y) were also obtained at the
Department of Neurosurgery, Kyushu University
Hospital. To assure optimal immunoreactivities,
only those tumors resected after 1975 were in-
cluded in the study.
Immunohistochemistry for PGDS was performed
on paraffin sections of brain tumors and soft-tissue
HPCs by the indirect immunoperoxidase method.
Surgical specimens of the tumors were fixed in
10% buffered formalin overnight and embedded in
paraffin. The samples were then cut into 5-?m sec-
tions. The sections were deparaffinized in xylene
and hydrated in an ethanol gradient. The endoge-
nous peroxidase activity was blocked with 0.3%
H2O2in absolute methanol for 30 minutes at room
temperature. The sections were then washed in TB
(50 mM Tris-HCl, pH 7.6), followed by overnight
incubation with the PGDS antibody (1:2000 dilu-
tion, kindly supplied by Mr. Oda, Central Research
Institute, Maruha Corporation, Tsukuba, Japan) at
4°C. After being washed in TB, the sections were
incubated with horseradish peroxidase-conjugated
secondary antibody (1:200 dilution, Vector Labora-
tories, Burlingame, CA). The colored reaction prod-
uct was developed with 3,3'-diaminobenzidine tet-
rahydrochloride (3,3'-diaminobenzidine) solution.
The sections were counterstained lightly with he-
matoxylin. The tests were done together with an
appropriate positive control (meningioma).
Immunoblot Analysis
The specificity of the polyclonal antibody against
PGDS in tumor tissue was assessed using a soluble
fraction extracted from frozen tumor samples of
meningeal HPCs and meningiomas. The samples
were homogenized in 1.5 volumes of buffer con-
taining 2% sodium dodecyl sulfate, 2 mM EDTA, 2
mM phenylmethylsulfonyl fluoride, 50 mM Tris-HCl,
pH 6.8. The protein concentrations were deter-
mined by a modified Lowry's procedure using bo-
vine serum albumin as the protein standard. Lae-
mmli's sample buffer was added to this mixture,
and the samples were boiled for 5 minutes. Each
protein sample (15 ?g per lane) was separated on
12% SDS-polyacrylamide gel and transferred to a
polyvinylidene difluoride membrane (Millipore,
Bedford, Massachusetts). After blocking with 5%
low-fat milk in TBST (25 mM Tris-HCl, pH 7.6; 0.15
M NaCl; 0.05% Tween 20; 0.05% NaN3), the mem-
brane was incubated at 4°C overnight with anti-
PGDS antibody (1:2000) in TBST containing 5%
low-fat milk. After it was washed, the filter was incu-
bated with the alkaline phosphatase-conjugated
secondary antibody (1:7500 dilution, Promega,
Madison, WI), and the blot was visualized by the
substrates of 5-bromo-4-chloro-3-indolyl phos-
phate and nitroblue tetrazolium.
TABLE 1. PGDS Immunoreactivity in Meningeal
LocationNumber of CasesPGDS Immunopositivity (%)
Thoracic spine
14 (78)
1 (33)
1 (25)
16 (64)
PGDS, prostaglandin D synthase.
TABLE 2. PGDS Immunoreactivity in Soft-Tissue
LocationNumber of CasesPGDS Immunopositivity (%)
Other regions
1 (7)14
PGDS, prostaglandin D synthase.
TABLE 4. PGDS Immunoreactivity in Meningiomas
SubtypeNumber of CasesPGDS Immunopositivity (%)
15 12 (80)
PGDS, prostaglandin D synthase.
TABLE 3. PGDS Immunoreactivity in Mesenchymal
Location Number of CasesPGDS Immunopositivity
PGDS, prostaglandin D synthase.
198 Modern Pathology
Page 3
Clinical Information
Of the 25 meningeal HPCs, 18 (72%) were supra-
tentorial, commonly parasagittal or falcial; 3 (12%)
were infratentorial, one each located in the
cerebello-pontine angle, jugular foramen, and tor-
cular Herophili; and 4 (16%) were in the thoracic
region (Table 1). No purely intraparenchymal HPC
was encountered. Fourteen soft-tissue HPCs were
located in a variety of somatic regions, including
four in the retroperitoneum; two in the femur; two
in the buttock; and a single case each from the
breast, shoulder, and anterior sacrum (Table 2). The
single case of mesenchymal chondrosarcoma was
located in the parietal region (Table 3). Fifteen
cases of meningioma consisted of four subtypes,
including seven meningothelial, three fibrous, three
transitional, and two secretory (Table 4). Among the
meningiomas, 12 cases were supratentorial.
Meningeal and soft-tissue HPCs were typical cel-
lular tumors composed of oval to slightly spindle
cells with oval, occasionally elongated nuclei (Fig.
1A). Nuclear atypia and mitosis were seen but var-
ied from case to case. The tumor cells grew as
monotonous sheets, interrupted by numerous slit-
like vascular spaces lined by flattened endothelial
cells. So-called staghorn sinusoids were identified
in all cases. Mesenchymal chondrosarcoma showed
a biphasic pattern of well-differentiated cartilage
alternating with cellular portions resembling an
HPC. Meningiomas had a wide range of histopatho-
logical appearances characteristic of the subtypes.
The results of our immunohistochemical analysis
for PGDS are summarized in Tables 1–4. Meningeal
HPCs were immunopositive for PGDS in 64% of all
cases examined (Table 1). Especially those in the su-
pratentorial region showed more frequent immuno-
reactivity (78%) than did those in either the infraten-
torial regions (33%) or the thoracic cord (25%).
Staining tended to be focal and patchy compared
with meningioma; however, perinuclear, granular cy-
toplasmic staining resembling meningioma was ob-
served (Fig. 1B). PGDS expression was observed in
neither soft-tissue HPC (Table 2, Fig. 1C) nor mesen-
chymal chondrosarcoma (Table 3), except for a single
case of soft-tissue HPC located at the sacrum (Fig.
1D). Meningioma showed higher frequency (80%) of
immunostaining for PGDS (Table 4). Typical staining
was observed around the perinuclei (Fig. 2, A–B). Two
cases of fibrous meningioma and one case of secre-
tory meningioma showed no immunoreactivity for
PGDS. Neither CPPs nor oligodendrogliomas were
immunopositive for PGDS.
FIGURE 1. Hemangiopericytomas of both meninges and soft tissue. A, meningeal hemangiopericytoma (HPC) is a cellular and vascular tumor
composed of round to oval cells with oval nuclei that is indistinguishable from soft-tissue HPC (HE). B, immunohistochemical staining for
prostaglandin D synthase (PGDS) in meningeal HPC reveals perinuclear, cytoplasmic immunoreactivity. C, soft-tissue HPC. Immunoreactivity for
PGDS is not observed. D, soft-tissue HPC of the sacrum. The tumor shows cytoplasmic staining for PGDS resembling meningeal HPC. (bar ? 50 ?m)
PGDS in Meningeal Hemangiopericytoma (M. Kawashima et al.) 199
Page 4
Immunoblot Analysis
The results of immunoblotting are shown in Fig-
ure 3. The extracts from meningeal HPCs (Lanes 1
and 2) showed a band (29 kDa) corresponding to
PGDS. Meningiomas (Lanes 3–5) also showed a
same–molecular-weight band.
PGDS is the enzyme responsible for biosynthesis
of prostaglandin D2(PGD2) in the central nervous
system and is identical to a major CSF protein,
?-trace (11–13). PGD2had long been considered a
minor and biologically inactive prostanoid. In the
late 1970s, Hayaishi et al. (14) found large amounts
of PGDS in the brains of rat and other mammals,
including humans. PGD2circulates in the ventric-
ular system, subarachnoid space, and extracellular
spaces of the brain and interacts with receptors on
the ventromedial surface of the rostral basal fore-
brain to initiate the signal to let the brain sleep (15).
PGDS is a member of the lipocalin superfamily
composed of various secretory lipophilic ligand-
carrier proteins (6, 7). However, its primary role in
the brain remains unclear.
PGDS is mainly synthesized in the arachnoid
cells, the choroid plexus, and oligodendrocytes in
the central nervous system (8, 10). Recently PGDS
expression in testis and heart has been reported
(16, 17). PGDS mRNA is detected by in situ hybrid-
ization in mouse embryonic mesenchymal cells
destined to become arachnoid cells and later in the
developing testis (18).
PGDS in the CSF is altered in various brain dis-
eases, including meningitis, multiple sclerosis, sub-
arachnoid hemorrhage, and infarction (19, 20). A
recent report revealed that the level of PGDS in CSF
increased in various brain tumors (21). It may con-
tribute to regulate the permeability of the meninges
(20). PGDS has been considered a specific cell
marker of meningiomas. Meningioma cells showed
intense immunoreactivity in the perinuclear region,
and that was often concentrated within meningo-
cytic whorls and around calcifying psammoma
bodies (10). We also examined immunoreactivity
for PGDS in three CPPs and seven oligodendrogli-
omas because choroid plexus and oligodendrocytes
are weakly immunopositive for PGDS in the central
nervous system. They showed no immunoreactivity
for PGDS. Thus, we could strengthen the idea that
PGDS has a specificity for meningiomas.
In this study, meningeal HPC showed relatively
high frequency (64%) of immunoreactivity to PGDS.
Moreover, soft-tissue HPC showed no immuno-
staining for PGDS except for a single case at the
surface of the sacrum, which might be associated
with the meninges. Because the histological fea-
tures so common to meningeal HPC are often en-
countered in mesenchymal chondrosarcoma, the
tumor was also investigated for PGDS immunore-
activity. Because it is rare, only a single case was
investigated, and it proved to be immunonegative
for PGDS. These findings indicate that meningeal
and soft-tissue HPCs are distinctive in view of their
PGDS expression. PGDS is widely expressed in the
human body; however, the fact that only meningeal
HPCs express PGDS means that they may be more
closely related to arachnoid cells.
Meningioma and meningeal HPC are currently
classified as different entities, but both showed posi-
tive immunoreactivity for PGDS. These tumors
(10) presented 100% positive immunoreactivity for
PGDS in all meningioma cases, including meningo-
thelial, transitional, fibrous, angiomatous, and atypi-
cal meningiomas. In the present study, meningiomas
showed a lower frequency of immunopositivity (80%)
for PGDS than that observed by Yamashima et al.
Moreover, the cases that were immunonegative for
PGDS consisted of subtypes of fibrous and secretory
meningiomas. In transitional meningiomas, menin-
FIGURE 2. Meningothelial meningioma immunostained for
prostaglandin D synthase (PGDS). A and B, the tumor shows
perinuclear, cytoplasmic staining for PGDS similar to the positive
pattern in the meningeal hemangiopericytoma. (bar ? 50 ?m)
FIGURE 3. An immunoblot probed with anti–prostaglandin D
synthase (PGDS) polyclonal antibody. Lanes 1 and 2, meningeal
hemangiopericytomas (HPCs); Lanes 3, 4, and 5, meningiomas. The
extracts from meningeal HPCs and meningiomas showed a band (29
kDa) corresponding to PGDS. Prestained molecular weight standards
(by Bio-Rad, Hercules, California) are given in kilodaltons on the left.
200 Modern Pathology
Page 5
gothelial cells with round to oval nuclei tended to be
immunopositive for PGDS. The present study dem-
onstrated a 64% positive rate in meningeal HPCs,
which is a lower rate of positivity than that of menin-
giomas. When a meningeal HPC located in the supra-
tentorial region is compared with meningioma, the
difference of PGDS expression is not remarkable (78%
infratentorial meningiomas. The meningiomas that
showed negative immunoreactivity for PGDS were
supratentorial tumors. The positive rates of supraten-
torial HPCs and supratentorial meningiomas were al-
most the same (78% versus 75%). The common ex-
pression ofPGDSin
meningioma may be related to cranial mesenchymal
cells. In the central nervous system, primitive mesen-
chymal cells destined to become arachnoid cells or
pericytes exist. Recently, it was reported that multi-
potent mesenchymal stem cells were isolated from
adult bone marrow, and they were induced to differ-
entiate into a variety of mesenchymal tissues (22, 23).
In situ hybridization studies by Hoffmann et al. (18)
showed cellular localization of PGDS mRNA during
postconception, PGDS mRNA was found to be con-
densed only in the leptomeningeal cells of the brain
and spinal cord. Later, at 16.5 days postconception,
choroid plexus epithelial cells and single cells within
the brain parenchyma were labeled at a significantly
lower rate than arachnoid cells. These findings sug-
gest that PGDS plays a more important role in the
arachnoid cells than in the choroid plexus and brain
parenchyma (oligodendrocytes). It is speculated that
if they become neoplastic, PGDS expression may ac-
company the change. To test this hypothesis, PGDS
expression in primitive mesenchymal cells should be
In conclusion, meningeal HPCs may have a dis-
tinct molecular phenotype compared with soft-
tissue HPCs, and they are more closely related to
the arachnoid cells in origin.
Acknowledgments: We thank Prof. M. Tsuneyoshi
and Dr. Y. Oda for providing materials and comments,
Ms. K. Hatanaka for her excellent technical assistance,
and Ms. K. Ono for reviewing the manuscript.
1. Bailey P, Cushing H, Eisenhardt L. Angioblastic meningioma.
Arch Pathol Lab Med 1928;6:453–90.
2. Stout AP, Murray MR. Hemangiopericytoma. A vascular tumor
featuring Zimmermann's pericytes. Ann Surg 1942;116:26–33.
3. Begg CF, Garret R. Hemangiopericytoma occurring in the
meninges. Cancer 1954;7:602–6.
4. Iwaki T, Fukui M, Takeshita I, Tsuneyoshi M, Tateishi J. He-
mangiopericytoma of the meninges: a clinicopathologic and
immunohistochemical study. Clin Neuropathol 1988;7:93–9.
5. Hayaishi O. Tryptophan, oxygen, and sleep. Annu Rev Bio-
chem 1994;63:1–24.
6. Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, et
al. Human brain prostaglandin D synthase has been evolu-
tionarily differentiated from lipophilic-ligand carrier pro-
teins. Proc Natl Acad Sci U S A 1991;88:4020–4.
7. Peitsch MC, Boguski MS. The first lipocalin with enzymatic
activity. Trends Biochem Sci 1991;16:363.
8. Urade Y, Fujimoto N, Kaneko T, Konishi A, Mizuno N,
Hayaishi O. Postnatal changes in the localization of prosta-
glandin D synthase from neurons to oligodendrocytes in the
rat brain. J Biol Chem 1987;262:15132–6.
9. Urade Y, Kitahama K, Ohishi H, Kaneko T, Mizuno N,
Hayaishi O. Dominant expression of mRNA for prostaglan-
din D synthase in leptomeninges, choroid plexus, and oligo-
dendrocytes of the adult rat brain. Proc Natl Acad Sci U S A
10. Yamashima T, Sakuda K, Tohma Y, Yamashita J, Oda H,
Irikura D, et al. Prostaglandin D synthase (?-trace) in human
arachnoid and meningioma cells: roles as a cell marker or in
cerebrospinal fluid absorption, tumorigenesis, and calcifica-
tion process. J Neurosci 1997;17:2376–82.
11. Hoffmann A, Conradt HS, Gross G, Nimtz M, Lottspeich F,
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12. Watanabe K, Urade Y, Mäder M, Murphy C, Hayaishi O.
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PGDS in Meningeal Hemangiopericytoma (M. Kawashima et al.) 201


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BusinessAviationVoice: Learjet 75 A Newcomer To Poland
As a brand, the name 'Learjet' has long enjoyed iconic status, with some 2,300 in use by corporations and private owners worldwide. So it should come as no surprise that certain models—all products of Bombardier Aerospace—continue to be among the most desirable business jets around the world.
One of them is the $13.8-million Learjet 75, read »Tony Velocci, Business Aviation


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Refine Results
46 associate project manager jobs in Newcastle upon Tyne, England (UK)
Associate Director - Project Manager
AMEC 100+ Reviews – Newcastle upon Tyne, England
Working within the AMEC E&I UK business you will have responsibility for developing, securing and delivering a wide range of engineering-based… AMEC
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Project Manager
Asset Appointments – South Shields, England
will include: • Scoping and planning of projects as directed, ensuring adequate documentation and controls are in place • Ensuring quality and… TotalJobs.co.uk
- Web Search
IS Assistant Project Manager – new
Home Group Ltd 6 Reviews – Newcastle upon Tyne, England
We are embarking on the implementation of a new IS Strategy, that involves the design and deployment of a new IT infrastructure and the procurement… TotalJobs.co.uk
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Senior Quantity Surveyor/Associate
Brierley J Recruitment Ltd – Newcastle upon Tyne, England
The ideal candidate will be from a consultancy background either as a Quantity Surveyor or as an Employers Agent and will be MRICS or at working… Reed.co.uk
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Senior Project Manager
Jonathan Lee Recruitment 2 Reviews – Durham, England
will include, but not be restricted to: Project reporting to senior management. Production and review of reports. Preparation of tender documents… Reed.co.uk
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Data Analyst
Sellick Partnership – Newcastle upon Tyne, England
*Work closely with the Head of Analytics and the academic partner. *Checking and collating of data submissions *Support Quantitative analysis across… Reed.co.uk
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Hire Projects Coordinator
Portakabin Ltd 2 Reviews – Newcastle upon Tyne, England
A successful international company producing some of the most advanced building systems available. Portakabin buildings are available for… Reed.co.uk
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Project Coordinator
Zenith People LTD – Newcastle upon Tyne, England
Create project procedures and update relevant documents Work closely with Project Managers to create CAD drawings Carry out general administration… Reed.co.uk
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Foreman (Civils)
Reed Property and Construction – Newcastle upon Tyne, England
Experienced Foreman with civils experience required The client is a specialist contractor, providing surfacing and associated civil engineering… Reed.co.uk
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Technology Architect
Accenture 100+ Reviews – Newcastle upon Tyne, England
Welcome to Accenture, one of the world's leading providers of management consultancy and IT services. Are you ready to put yourself to the test on… EmptyLemon
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Quality Engineer
Solutions Recruitment – Hartlepool, England
will include: • ensuring compliance to QMS procedures • carrying out quality and environmental audits and inspections throughout manufacturing… Reed.co.uk
- Overview
Project Engineer
Jenrick Engineering – Washington, North East England, England
of varied engineering projects. Key responsibilities: - Managing engineering projects… CV-Library.co.uk
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Site Engineer (Civils)
Reed Property and Construction – Newcastle upon Tyne, England
Site Engineer required The client is a Major Contractor providing civil engineering and associated services to the highways and Infrastructure… Reed.co.uk
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Associate - Highways
Vertical Recruitment Limited – Newcastle upon Tyne, England
Reporting to Associate Director. You will be office based at the Newcastle office to manage the delivery of a range of projects. You will be… CV-Library.co.uk
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Project Engineer
CDS Recruitment ltd – Washington, North East England, England
" The management of project engineering projects associated with the new installation or relocation of machinery on behalf of key customers who… CV-Library.co.uk
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In an intimate exhibition featuring master drawings by Leonardo ...more
Our hotels are trimmed with seasonal specialties and are perfectly wrapped for your holiday pleasure.
Boston's stores and shops are dressed in their holiday best. Our parks and plazas outshine one another, our streets are garlanded and bowed and each store window is more inviting than the last.
Many restaurants offer signature culinary events at this festive time of year from Breakfast with Santa to Nutcracker Brunches to New Year's Eve.
Print a list of Holiday Hits!


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On the Scene: 140 random characters
|| Print |
|On the Scene
|Tuesday, May 24, 2011
The 140 Characters Conference NW focuses on the changing ways people are communicating now thanks to social media. A wide variety of speakers, from business and nonprofit leaders to government officials, spoke on the way social media helps them engage a wider audience and connect with people in ways never before possible.
The consensus was that social media has made leaps and bounds since its inaugural stereotype of a way to show the world what you had for dinner. Increasingly, Twitter and Facebook are serving as useful online tools for public agencies. Of all the 140 Characters Conferences with high-ticket locations such as New York City and London, the free event in Vancouver, Wash., was the first to target the public sector.
Since the conference was aimed at public sector organizations, it was partially sponsored with grant funds from Homeland Security Region 4 in SW Washington, hence the conference's somewhat confusing location across the river.
The #140ConfNW was held from 8 a.m. to 5 p.m. at the Vancouver Convention Center in the Vancouver Hilton. Presentations were livestreamed online, with many people expected to watch the conference from the comfort of their homes instead of joining the 100 or so attendees at the Convention Center. Perhaps this was the reason the actual attendee turnout was much lower than the Vancouver Tourism Office's originally projected number of 900 people.
Jeff Pulver, founder of the #140 Characters Conference series, gave the opening remarks.
The conference was divided into short, rapid-fire 10 minute presentations, with a wide array of topics from food carts to disaster response. Attendees listened to speaker's stories and tweeted their favorite quotes, creating a real-time conversation online. Rather than surreptitiously surfing the Internet on their iPhones under the table while attending a conference, at #140ConfNW, attendees were encouraged to have a conversation with one another via Twitter. This made for an interesting conference audience, with half the attendees watching the presenters, and half looking down at their laps, furiously typing away.
Portland Mayor Sam Adams spoke at the conference in the morning. He has gotten a lot of press for his liberal use of Twitter, much of it negative. Adams, who has almost 35,000 Twitter followers, said he is often asked "How can you run the city if you're always tweeting?" "How can I run a city without tweeting?" Adams asked.
Amid all the talk of how social media can help nonprofits, businesses and government agencies, some presenters chose to point out the downsides of the new media. Simon King, CEO of WordSpreadz, described how Rebecca Black's YouTube video of the song "Friday" received more views and social media buzz after its posting in February than many other more notable recent events combined, including such tragedies as last year's Haiti earthquake or the recent Japan tsunami.
King likened the advent of the Internet and social media platforms to the invention of fire. "Let's not waste this Promethean fire; let's prove to the Gods that we deserve this power," King said. "The world is much deeper than 140 characters, and so are every one of you."
Emma Hall is web editor for Oregon Business.
|Get on the bus!
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A new report highlights how Oregon bankers are giving back to their communities.
Since 1932 Tidewater Transportation & Terminals (operating as Tidewater Barge Lines and Tidewater Terminal Company) has operated a multicommodity transportation and terminal company based in Vancouver, Washington. The friendly expression on the company's shipping containers reflects the attitude of about 330 safety and community-conscious employees but belies how complicated the barge business really is.
The Port of The Dalles has run marine facilities since the 1930s, but they are part of a larger mission to strengthen the local economy. They focus on regional economic development with a strong bent toward adding good-paying jobs in high tech, manufacturing and other industries.
Like the advent of the locomotive, the cloud creates business opportunities that simply weren't possible before now. Get up to speed fast in May at an exciting cloud-empowered Portland event.
Registration is now open for Portland Business Alliance's Annual Meeting, one of the largest business gatherings in Portland each year.
The Commission helps to advance the professionalism, equality and efficiency of Oregon's judicial branch of government.


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Elizabeth Ann Burns Boon (born 1830)
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Elizabeth Ann Burns Boon (born 1830) was born in 1830. She was born into the Burns family and married into the Boon family.
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|Blog Posts
Vitamin D and Athletes
Vitamin D is not just a sun-derived vitamin, but is a crucial steroid precursor that is transformed into one of the most potent hormones in the human body for strength, power, lung function and regulating gene expression in every organ system.
Athletes need Vitamin D.
Dr. Cannell has written quite extensively about the role of vitamin D in athletes.
See prior post: 'Roid Rage Vitamin D3 -- DO IT (Part I)
Don't miss Dr. T's recent post: Vitamin D Summary of Actions . SUPERB!
Vitamin D: Flu, Asthma, Bronchitis, H1N1 Protection
Swine Flu H1N1.
Worried? Don't be.
Baby wanna be a millionaire? Vitamin D3... just do it. Baby by me, 50 cents YO.
Many factors can predispose an individual to be immunocompromised and more susceptible to the flu or H1N1 or bronchitis--sleep deprivation
--mental stress
--excessive physical training
--hypothyroidism, adrenal fatigue
--poor, unbalanced gut biofilms (read Dr. Ayers Cooling Inflammation )
--gluten/wheat, lectins, omega6 and associated inflammation
--nutritional deficiencies
--et cetera
Vitamin D stores may be depleted under all the circumstances above.
For the past season, naturally, I've been a total ding dong, frequently skipping my vitamin D supplement and sunlight. Yeah missed a boatload of doses. (*haaa* Yeah, I am THE vitamin-D-fairy-godmother and I hand it out like candy... wtf I s*ck) So... Three weeks ago my asthma came back full force and within days I was in the middle of a bronchitis/coughing attack again with a fever for 2 days. Last episode was EONS ago. Couldn't shake it but after a boost of vitamin D via a modified Stoss protocol (20,000 to 50,000 IU for 3 days) that Dr. Cannell frequently discusses for prophylaxis or acute treatment of influenzae or other viral infections, my coughing and infection were completely gone. My cough was almost gone OVERNIGHT. On the other hand, Dr. Cannell talks about much higher doses. Since I was not deficient, just 'insufficient', I used a lower dose.
The bronchitis was entirely aborted, shortened to a few days not a few MONTHS or a few WEEKS like the normal course of chronic bronchial inflammation I had experienced annually in the past. I ran 13.1 miles a week later and was fine (though my power and pace s*cked). My ghetto batgrrrl picture wasn't so bad though *wink*. Vitamin D does a body better. My skin, hair, muscles, recovery, breathing and body fat are all far better now that I'm back on the program.
Prior post: Stoss protocol Vitamin D3 Nature's Antibiotic
Vitamin D deficiency and chronic lung disease. Gilbert CR, Arum SM, Smith CM. Can Respir J. 2009 May-Jun;16(3):75-80.
Vitamin D and respiratory health. Hughes DA, Norton R. Clin Exp Immunol. 2009 Oct;158(1):20-5. Review.
Vitamin D Associated with Fitness, Power, Strength and Lower Body Fat
Two research articles highlight the relationship between higher vitamin D levels and athletic performance. The first showed a positive relationship between higher VO2 max and higher blood vitamin D (p<0.05) in n=59 adolescent and young females. Incidentally, lower body fat (p<0.05) was associated with higher vitamin D levels.
The second study reviewed baseline vitamin D concentrations (which were LOW low low) in 99 female athletes age 12-14 yo and found "Jumping mechanography to measure muscle power, velocity, jump height, and Esslinger Fitness Index from a two-legged counter movement jump and force from multiple one-legged hops was performed. Body height, weight, and serum concentrations of 25(OH)D, PTH, and calcium were measured. RESULTS: Median serum 25(OH)D concentration was 21.3 nmol/liter (range 2.5-88.5 [median 8 ng/ml with range 1-35.4 ng/ml]) and PTH 3.7 pmol/liter (range 0.47-26.2). After correction for weight using a quadratic function, there was a positive relationship between 25(OH)D and jump velocity (P = 0.002), jump height (P = 0.005), POWER (P = 0.003), Esslinger Fitness Index (P = 0.003), and force (P = 0.05). There was a negative effect of PTH upon jump velocity (P = 0.04). CONCLUSION: From these data we conclude that vitamin D was significantly associated with muscle power and force in adolescent girls."
Girl Power!
Association among cardiorespiratory fitness, body fat, and bone marker measurements in healthy young females.
Mowry DA, Costello MM, Heelan KA. Mowry DA, Costello MM, Heelan KA. J Am Osteopath Assoc. 2009 Oct;109(10):534-9.
Vitamin D status and muscle function in post-menarchal adolescent girls.
Ward KA, et al. J Clin Endocrinol Metab. 2009 Feb;94(2):559-63.
Vitamin D Alters Gene Expression
Many components of our diet are in fact potent modulators of genetic expression. Vitamin D is among many. In a variety of clinical trials, vitamin D lowers CRP (inflammation), increases testosterone (I've seen it and HH reports his anecdotal experience here ), thyroid hormone, and (in rats) raises estrogen. Is this helpful for athletes? There are many mechanisms by which vitamin D exerts benefits for athletes including improved breathing, lung function, oxygenation, immunity protection, muscle strength, endurance, muscle power and hormone optimization (e.g. the big 'T').
Micronutrients and amino acids, main regulators of physiological processes. Verheesen RH, Schweitzer CM. Med Hypotheses. 2009 Oct;73(4):498-502.
Ask Your MD for A Blood Test
Tracking of blood vitamin D levels (known as [25(OH)D]) is necessary to make sure you have the optimal range, not too high and not too low. Other labs to track are calcium and magnesium (and PTH if you have plaque or chronic kidney disease). Supplementation with either over-the-counter Vitamin D3 or prescription ergocalciferol (which is inferior and should be avoided) is contraindicated if you have a condition called sarcoidosis or isolated hypercalcemia (high calcium).
With dose initiation or increases, the blood levels take about 4-6 wks to stabilize. Consider requesting a blood test to confirm the value (either self-directed ZRT at heartscanblog or the vitaminDcouncil.org).
Dr. Harris MD discusses the accuracy of the vitamin D tests available on the market. Don't be blinded by his scorching hot brilliance or body. Paleo nutrition blog: HERE and HERE .
Dr. Cannell MD advises goal serum vitamin D [25(OH)D] 60 to 80 ng/ml (or 150-200 nmol/L). Personally my breathing and hormones appear to me the most optimal at 70s ng/ml. The past year I checked the [25(OH)D] twice and it was not more than 60. Incidentally, I did not feel so 'right on' as compared to when I had levels in the 70s. Everyone perhaps owns a 'set point' and you might need to figure what that is for yourself depending on your athletic performance, pulmonary function, immunity, mood and other metrics.
Hopefully your doc will not ignore the healing power of diet and certain nutritional supplements like vitamin D. (bwt don't bring the below article in -- the suggested doses are pathetically low baby doses).
Low Vitamin D = Low Strength
Low serum Vitamin D concentrations are independently associated with SARCOPENIA decreased muscle strength
Write a comment:


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FEMA Could Withhold Funding From Governors Skeptical of Climat...Starting in March 2016, if state governors want to receive disaster-preparedness funds from the Federal Emergency Management Agency, new guidelines will require them to approve hazard-mitigation plans that address climate change. By Taylor Tyler ... Hngn.com, 3 days ago
President Obama Signs New Hampshire Disaster Declaration - OfficialWire, 2 days ago
President Declares Disaster for New Hampshire - FEMA, 2 days ago
113 images for state disaster management department
Disaster mgmt wing to focus on kids, road safety
PATNA: The Bihar State Disaster Management Authority (BSDMA) will focus on children and road safety at during Bihar Diwas programme from March 22 to 24. The 25-odd stalls of the pavilion will also focus on safe construction practices, hands-on ...Times of India, 1 week ago
Desperate hunt for Alps disaster clues
Three Americans were among the passengers, the U.S. State Department says Investigators brave treacherous terrain to search for clues in debris • 3:25 p.m. ET: FBI agents based in France, Germany and Spain are looking through intelligence ...Social Dashboard, 2 days ago
Vital to enhance disaster risk management
AT the recent Third United Nations World Conference on Disaster Risk Reduction held in Sendai, Japan, Deputy Prime Minister Tan Sri Muhyiddin Yassin spoke about the need for Malaysia to reshape its disaster management agencies to be more robust and ...New Straits Times, 3 days ago Strengthen our disaster risk management TheStar.com.my, 3 days ago Addressing disasters in Sendai Manila Standard Today, 1 week ago UN lauds India's improved disaster risk management Jagran Post, 3 weeks ago
Trustees oppose B-school's varsity upgrade
KOLKATA: Members of the trust running Indian Institute of Social Welfare and Business Management (IISWBM) oppose the state government's move to upgrade it into a university. They say they were kept in the dark about the proposal. "We are not aware ...Times of India, 1 week ago
Start managing disaster threat or risk development gains - experts
SENDAI, Japan, March 16 (Thomson Reuters Foundation) - When Typhoon Haiyan sent storm surges and high winds across the islands of the central Philippines in November 2013, it wrecked homes, schools, hospitals and roads, as well as killing more than ...AlertNet, 1 week ago
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3rd Water Conference from Feb 6
GUWAHATI, Feb 3 - The state's Water Resources Department (WRD) is hosting the two-day Third Assam Water Conference-2015 with a focal theme of 'Management of Water-Related Disasters - Urban and Rural,' from February 6 at the Basistha campus of its Assam Water ...The Assam Tribune, 1 month ago
Stock Update: The Boeing Company (NYSE:BA) U.S. approves $1 bln Boeing CH-47 Chinook sale to Netherlands
[Reuters] The U.S. State Department has approved the sale of 17 Boeing Co CH-47F Chinook cargo helicopters to the Netherlands, a deal that would be worth around $1.05 billion, the U.S. Defense Security Cooperation Agency said this week. DSCA said ...Jutia Group, 2 days ago US clears CH-47F Chinook helicopters sale to Netherlands Air Force Technology, 3 days ago
US Federal Business Opportunity: Department of Labor: REQUEST FOR PROPOSAL Site Exposure Matrices (SEM) Database Services
Agency: Department of Labor Office: Office of the Assistant Secretary for Administration and Management Location: Office of Procurement Services Date you need to respond by: 17-March-2015 Solicitation Number: DOL-OPS-15-R-00012 Naics code: 541620 ...ITbriefing, 3 days ago Combine Solicitation - T.S. KENNEDY - FY15 ABS Special Periodical Survey Drydocking Insurance News Net, 3 days ago Combine Solicitation - USPSC - OTI Program Manager - Washington, D.C. (Ladder, Multiple Positions) Insurance News Net, 3 days ago Presolicitation Notice - PREVENTATIVE MAINTENANCE AGREEMENT Insurance News Net, 4 days ago
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Opening Ceremony Kicks Off Disaster Management Exercise Gobi Wolf 2015
The Deputy Chief of Mission Kirk McBride making an opening remarks on the first day of the Gobi Wolf Exercise 2015. USARPAC Deputy Commanding General MG Gregory C. Bilton, NEMA Chief BG T.Badral, PRMC Commander BG P. Sargent and NEMA DPD ...US Embassy Mongolia: Ulaanbaatar, 3 days ago
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Free forum : A Minecraft Community.
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A community based around interactive connectivity between all members. Provided by forumotion, this non-profit website is free to everybody.
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Free forum : Japan Attack is a server based on Japan's drifting cultures as well as the virtual dimension abroad. Hosted by us! ! ! Team Free Spirit! ! !
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Free forum : We are a Runescape private server by the name of RedemptionScape. Revision- 667Main Owner- ZenithWebsite Developer- Chronic
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Find help and support for managing your BreederZOO Pro or Server Dog breeding software database.
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Zeus player Corporation (corp) website for The Infinite Black (TIB) online MMO mobile game for iOS (iPhone/iPad) and Android. New player guide (Recruit) and recruitment.
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Forum of the guild Lazarus, Draenor- EU server. Lazarus Guild Forum
Planetside 2 MEMBERS and SQUAD BOOSTS ONLY- Join us to get the most out of the money you put into this game by playing with other PAYING players like yourself and recieve EXTRA XP BONUS (Daily +200% XP Bonus Squads) . . . Alone you might. . . . . tog
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Welcome, this forum was made for the guild Gankster on the private wow server https://www.warmane.com/ on the PvP realm Warsong.
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This is a forum for the server on Rust Experimental (US Texas) Rust In Peace.
Here you can discuss Alex's minecraft server
Welcome To LudicrousYoshi's Server ForumIP: 188.8.131.52:25565 MCforum Post: http://www.minecraftforum.net/viewtopic.php?f=1014 &t=95694
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Renegade PS is a 667 RSPS devoted to making the best Runescape Private Server online! We have customs, drygores, tectonic, ascensions, and all working skills!
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"This website is well worth the time & money. It saved me so much time because instead of answering a lot of questions over & over, alI I had to do was refer potential buyers to the website where all of the pictures & details were listed. Couldn't have done it without this website."
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Mother nature has socked us good today with no signs of letting up, so track officials have canceled today's program. Don't forget, USCS Sprints will be in the house THIS FRIDAY!!
Next Event
Friday, March 27
Full racing program
plus Best Appearing Car Contest
Latest Tweets
- 63 crates at Duck River Speedway for the inaugural event for the new UCRA Crate Late Model Series.... http://t.co/EbDtw8TMNe about 19 hours ago ReplyRetweetFavorite
- Victory Lane Photos courtesy of Madison McCarter. about 22 hours ago ReplyRetweetFavorite
- The temps was frigid last night but the action was hot. Here's a few shots of last night's action courtesy of WRP's Chad Wells. about 23 hours ago ReplyRetweetFavorite
- Tanya and I appreciate everyone that braved the weather lastnight. If you wasn't there you missed a heck of a... http://t.co/Ra2u0HxW9S 08:12:10 AM March 28, 2015 ReplyRetweetFavorite


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Game Questions & Answers (Q&A) service lets you ask questions about video games for game consoles or PC games. So ask your Lego Star Wars 3: The Clone Wars question for 3DS and get answers from real gamers or answer questions and share your insights and experience with the rest of the gaming community.
Boxshot / Details
- Developer: Traveller's Tales
- Publisher: LucasArts
- Genre: Action Adventure
- Release Date: Mar 27, 2011
- ESRB: Everyone 10+
- Other Platforms
Stuck on this game? Set a specific, clearly defined question and let others answer your question or view answers to previously asked questions. If you think you are an Lego Star Wars 3: The Clone Wars expert then please try to help others with their questions.
No idea to find the Red Brick on christophsis
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Posted On: 03-10-2013
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No idea how to activate cheat code mode!
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Posted On: 05-28-2012
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Cannot find red brick
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Posted On: 02-27-2012
Posted On: 02-27-2012
Lego star wars 3 mini games
From: Robster
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Posted On: 08-05-2011
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Trailers & Gameplay Videos
Lego Star Wars 3: The Clone Wars - Debut Trailer
- Sep 6, 2014, Views: 139
Lego Star Wars 3: The Clone Wars - Official Launch Trailer
- Sep 6, 2014, Views: 79
Lego Star Wars 3: The Clone Wars - Destroy Malevolence
- Sep 6, 2014, Views: 79
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Lego Star Wars 3: The Clone Wars - Mission 3 Rookies
- Sep 6, 2014, Views: 49
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The frontrunners for the Republican nomination for president may be making a stop on Long Island soon.
The Long Island Association has reached out to both Mitt Romney and Rick Santorum about participating in a sit-down discussion of the issues.
LIA President Kevin Law said both parties are interested, and are currently trying to find a date that works for both to attend, but stressed their appearances would not be a debate.[dmc-related-post-wp numitems="3" title="Also read"]
Law said he's hoping to have the event a week before the New York Republican primary on Tuesday, April 24.
The LIA has also reached out to Newt Gingrich about participating in a potential event with the other GOP hopefuls, but has not heard back from his camp as of yet.
If Romney and Santorum weren't able to agree on a date for the discussion, Law said it was possible the LIA could hold separate events, but hoped that wouldn't be the case.
"The goal is to create a date that works for both of them," Law said.
More breaking news
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- LI hospitals making their owns news
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AUDIOPHILE: Theophilus London
Martha A. and Robert S. Rubin Pavilion, 1st Floor
The last of three concerts celebrating the most prolific and innovative emerging talent of Brooklyn's thriving music scene, including hip-hop, indie rock, electronic, and psychedelic bands. This concert will feature indie hip-hop artist Theophilus London and talented newcomers Phony Ppl. Produced in conjunction with The L Magazine. Free with Museum admission. Standing room only.
Upcoming Featured Event
Film and Discussion: Judy Chicago: A Butterfly for Brooklyn
Thursday, April 09, 2015
The premiere of a documentary about Judy Chicago's monumental site-specific pyrotechnic piece held on April 26, 2014, in Prospect Park, followed by a talk with the artist and others involved with the project. Read more.


text:
Updated: 04/23/2014 5:47 PM
Created: 04/23/2014 5:45 PM KSTP.com
By: Cassie Hart
The operators of Minnesota's state-run health exchange say a little more than 200,000 people have signed up for coverage through the exchange.
MNsure interim chief executive Scott Leitz says the exact number is 200,174.
March 31 was the deadline for most people to get coverage or face a tax penalty. The number of enrollees has been slowly climbing as the state continues to process people who started their application before the deadline. The state had set a goal of 135,000 people soon after the MNsure website launched last October and suffered severe technical issues.
MNsure recently signed a nearly $5 million contract with Deloitte Consulting to manage an overhaul of the website and computer systems.
(Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
|Woman's Body Recovered from Mississippi River Where U of M Student went Missing
|Shoreview Man Accused of Kidnapping 15-Year-Old Girl to Marry Her
|Mpls. Police: Video Shows Missing U of M Student Went into River from Bridge
|Profiler says Mpls. Sex Assault Suspect Indicates he Could Attack Again
|Wind-Whipped Flames Burn Homes Across Minnesota


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Posts tagged "80s nostalgia"
6 Essential Parenting Lessons From '80s Movies
I was a child of the '80s (and part of the '90s), which means I had plenty of exposure to what parenthood would really be like from iconic greats like Diane Keaton, Tom Selleck, Michael Keaton, Kirstie Alley, and Goldie Hawn. When I had kids, I was fully expecting to be a Manhattan exec turned…
Susan Finch
July 1, 2013
Can Jem And The Holograms Make A Truly Outrageous Comeback With New Dolls From Hasbro?
Jem, the larger, cooler Barbie. At least to me she was. That's why I'm so excited for this news. Hasbro has made a deal with Integrity Toys for a modern day line of Jem and the Hologram dolls. "Inspired by the TRULY OUTRAGEOUS characters created by Hasbro over two decades ago and cherished by fa…
The Mary Sue
October 28, 2012
Look! A "Full House" Reunion
Everywhere you look, there's a face of somebody who needs you. Well, they don't need you, more like we needed them back in the '80s. Those were the days.Watching "Full House" on TGIF, eating Burger King french fries, thinking there was a future for me on primetime television because D.J. Tanner was also chubby with…
Ami Angelowicz
September 24, 2012
A Little Aerobics To Get Your Blood Pumping
Something most people don't know about me: I grew up in an aerobics household. No, it wasn't my mom who was into it, although, I occasionally joined her as she danced along to the "Jazzercise" video tape. It was my dad who was the aerobics star. He spent most of the '80s as the only ma…
Ami Angelowicz
April 18, 2012
When Your Favorite Obscure Television Show Comes To DVD: The "Rags To Riches" Edition
I have just heard the news that my very favorite obscure '80s television show, "Rags to Riches," is going to be released on DVD in June. This is like a major event in my world. The two seasons that it ran on NBC (from 1986-1987) were some of the happiest TV moments of my childhood.
Ami Angelowicz
March 1, 2012
If Annie Is All Grown Up, That Means We Are Too
I may be over 30, but that doesn't make me too old to hold out hope for a Daddy Warbucks style adoption, right? So what if I own the "Annie" commemorative plate series or can still quote dialogue from the film? "First the windows, then the floors ... in case I drip." Even I knew…
Ami Angelowicz
January 27, 2012
"Jem And The Holograms" Was Deeper Than We Thought
"Just because the show was for kids, I would never write down. I would write the kind of deep, rich story that I would like to watch – just trusting it would communicate to the viewers, and it did. The characters were rich, and deep, and had a lot of life to them, a lot…
Ami Angelowicz
October 11, 2011
My Obsession With "Jem And The Holograms"
"Jem and the Holograms" was my favorite television show as a kid. The show tells the story of Jerrica, a rich girl whose dad leaves her a record company when he dies. He also leaves her a pair of earrings that allow her to communicate with Synergy, a holographic computer. Synergy allows Jerrica to create…
Kate Torgovnick/Kate-Book.com
September 27, 2011
Lisa Vanderpump Was In An ABC Video
I have a very soft spot in heart for ABC, the ultimate '80s band in my mind. As a kid, I remember absolutely loving their video for the song "Poison Arrow." It shows frontman Martin Fry lusting after a beautiful big-haired brunette, dripping in diamonds and fur, who eventually shrinks him and traps him under…
Kate Torgovnick/Kate-Book.com
September 26, 2011
"The Blues Brothers" And "Romancing The Stone" Getting Rebooted For TV Shows
For the past few years, '70s TV shows like "Charlie's Angels" and "Hawaii Five-O" have been the thing to reboot for TV shows. But now it feels like '80s movies are having their moment. Remember "Romancing the Stone," the 1984 flick starring Kathleen Turner as a romance novelist who heads to South America to…
Kate Torgovnick/Kate-Book.com
September 2, 2011
Simply Irresistible
All »
The 20 Hottest Sex Scenes From "Game Of Thrones"
When you play the game of thrones, you either win or you die. But you get to f*ck a lot first. So . . . it's kinda worth it. The show is known for its gratuitous amounts of nudity and raunchy sex, so what better way to celebrate the impending Game of Thrones Spring premiere…
Tres Sugar
March 29, 2015
The 10 Definitive Cult Films You Absolutely Must See
What makes a movie a "cult classic"? Film history is littered with hundreds of films that never made it big, but developed small, passionate followings that allowed them to build up a reputation over time. Sometimes a good film is poorly marketed by a studio more concerned with their bottom line; other times genuinely bad…
Ask Men
March 28, 2015
Dave Grohl Helps Out A Dying Fan
A big Foo Fighters fan with terminal cancer will get to scratch off one item from his wish list: meeting Dave Grohl and the band. The band was flying home from Australia when a flight attendant told Grohl about the wish of her friend, Australian Ken Powell, 56, who has late-stage melanoma, report…
March 28, 2015
Amanda Knox's Murder Conviction Has Been Overturned
Foxy Knoxy is off the hook.
Claire Hannum
March 27, 2015
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text: Share: Wild Game Recipes Looking for wild game recipes? Find wild game recipes including rabbit recipes, recipes for venison, and more recipes for wild game. Recipe Spotlight Bacon-Topped Venison Meat Loaf I caught my fiance eating this meat loaf cold, right out of the fridge! He encouraged me to send in the recipe. If you have a deer hunter in the family, be sure to give this a try. View Bacon-Topped Venison Meat Loaf Recipe Sign up for Our Recipeof the Day Newsletter New recipes and fan favorites delivering daily inspiration! SIGN UP More Wild Game Recipes Sort: Highest Rated Alphabetical Newest < prev | 1 | 2 | 3 | 4 | 5 | ... | next > Elk Meat Chili Elk Meat Chili "The longer this hearty chili simmers, the better it tastes!" remarks field editor Jo Maasberg of Farson, Wyoming. "It's a cold-weather favorite at our ranch." View Recipe Ground Venison Burgers Ground Venison Burgers Even folks who aren't fans of venison will enjoy these zippy burgers, deliciously topped with pepper cheese and a cool lime-mustard mayonnaise. "My son, who's an avid hunter, gave me this super recipe," says Jerry Honeyager of North Prairie, Wisconsin. View Recipe Spinach Venison Quiche Spinach Venison Quiche This exceptional quiche is a favorite of Gloria Long and her husband, Greg, from Morehead City, North Carolina. The spinach and venison are an unbeatable match, and the feta adds savory goodness. View Recipe Advertise with us ADVERTISEMENT Sweet-and-Sour Elk Sweet-and-Sour Elk Baked elk steaks smothered with a simple, savory sauce is a special dinner we've enjoyed for years. My husband, Ralph, and I used to do quite a bit of hunting, so I accumulated lots of terrific recipes like this one. -Susan Bowdle, Ephrata, Washington View Recipe Slow-Cooked Goose Slow-Cooked Goose "My husband, Willard, and I own a hunting lodge and host about 16 hunters a week at our camp," says Edna Ylioja from Lucky Lake, Saskatchewan. "The slow cooker makes easy work of fixing this flavorful goose dish, which is a favorite of our guests. The recipe makes lots of savory gravy to serve over mashed potatoes." View Recipe Bacon-Topped Venison Meat Loaf Bacon-Topped Venison Meat Loaf I caught my fiance eating this meat loaf cold, right out of the fridge! He encouraged me to send in the recipe. If you have a deer hunter in the family, be sure to give this a try. View Recipe Baked Venison Burgers Baked Venison Burgers "Since my husband is an avid hunter, we have an abundance of venison each winter," relates Teresa Bowen from Choudrant, Louisiana. "I adapted a meat loaf recipe to make these baked burgers, and we haven't eaten plain burgers since!" View Recipe Elk Parmesan Elk Parmesan Wyoming is a paradise for people like us who enjoy hunting. My husband was thrilled when our jobs brought us here over 20 years ago. I've been cooking game since I was a girl, so I use recipes like this enticing elk dish often. It's one of our favorites. -Dolores Crock, Cheyenne, Wyoming View Recipe Mountain Man Soup Mountain Man Soup This stew-like soup from Cordella Campbell of Rapid City, South Dakota is sure to satisfy your hearty hunter's appetite. It's chock-full of tender buffalo meat, tomatoes, and chunks of carrot and potato, lightly seasoned with bay leaf and clove. View Recipe Wild Rice Stuffed Cornish Hens Wild Rice Stuffed Cornish Hens My mom prepares this impressive-looking entree for the holidays and for other "company's coming" occasions. The savory rice stuffing goes wonderfully with the moist golden hens and sweet apricot glaze. She is often asked for the recipe. -Becky Brunette, Minneapolis, Minnesota View Recipe Baked Trout Fillets Baked Trout Fillets Moist tender trout is draped in a creamy Parmesan cheese coating that makes this dish elegant enough to serve company. "I picked up this recipe at the campground where we were staying," says Mary Zimmerman of Spring Lake, Michigan. "I also use the delicious sour cream mixture on salmon." View Recipe < prev | 1 | 2 | 3 | 4 | 5 | ... | next > Advertise with us ADVERTISEMENT Advertise with us ADVERTISEMENT


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Whether you're enhancing or optimizing existing code or just starting from scratch, there's never a better time to start integrating object-oriented design techniques. This course shows how to integrate the principles of object-oriented programming into the build of a PHP-driven web page or application. After an overview of what objects and classes are and why they should be used, author Jon Peck dives into creating and instantiating objects, then defining the class relationships and interactions that will form the basis of your coding arsenal. The course also shows how to leverage PHP objects and implement design patterns, and looks at steps you can take to continue adding to your programming tool belt.
Sometimes, you will want to make a copy of an object.
There are many reasons to do this, including making a backup before performing an
operation, or as a shortcut for defining a similar object.
To create a copy of an object, use the clone keyword. As a demonstration, make a
copy of the park address, open the demo script, and navigate to the bottom. Add
the following lines:
Cloning AddressPark $address_park_clone = clone $address_park. And
then, we'll debug the clone.
To check the differences between clones, I'm going to compare two objects. Comparing objects is a lot like comparing primitives, such as strings and floats. I can use the comparison operator, double equals (==), which will check to see if the properties are the same. If I need to be more strict, I can use the identity operator, triple equals (===), to also check if both objects are instances of the same class. At the end of the script, add echo $ address_park_clone_ is. And then, a ternary statement. $address_park == $address_park_clone ? : not ] a copy of $address_park. Save the demo, and refresh the browser.
Visually, every property is the same, and the final line indicates this. However, the time created isn't necessarily the same, especially if one object is based on an old record from the database. To deal with this, I'm going to use the _ clone() magic method in the address class. If the method exists, it will be called after object cloning. As an example, I am going to use this to reset the time created. Let's go back to the address class. Then, after the properties, add the clone method, which takes no arguments. Remember to add proper documentation.
For the demonstration, I will explicitly set the time_created and time_updated to obvious values. Save, then switch to the browser, and refresh. The time_updated and created have been set to the new values, and the final line states that $address_park_clone is not a copy of $address_park. Return to the clone function, and set time_ created = time, and time_updated = Null. Now that I've demonstrated object cloning, I am going to discuss how to reference objects.
Referencing can be similar to cloning, but there are enough differences to make it worth exploring on its own.
Find answers to the most frequently asked questions about Object-Oriented Programming with PHP .
Here are the FAQs that matched your search "" :
Q: This course was updated on 4/10/2013. What changed?
A: The author rerecorded some of the tutorials to add more background information and better graphics.
A: The author rerecorded some of the tutorials to add more background information and better graphics.
Sorry, there are no matches for your search "" —to search again, type in another word or phrase and click search.
Access exercise files from a button right under the course name.
Search within course videos and transcripts, and jump right to the results.
Remove icons showing you already watched videos if you want to start over.
Make the video wide, narrow, full-screen, or pop the player out of the page into its own window.
Click on text in the transcript to jump to that spot in the video. As the video plays, the relevant spot in the transcript will be highlighted.


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Monday, 16 Dec 2013 08:48 AM
PESHAWAR, Pakistan — Police say a roadside bomb has killed three members of a Pakistani bomb disposal team who were on their way to defuse another bomb elsewhere in the city of Peshawar.
Police officer Shahid Khan says the attack took place early Monday in the Shaikh Mohammadi suburb. He says the three-member team was on its way to defuse a bomb that was uncovered in the Suleman Khel district.
The three victims were identified as bomb disposal expert Abdul Haq and his two aides. Khan says that after the incident, police found another bomb nearby, which was later defused.
The suburbs of Peshawar, which lies close to tribal regions, have seen scores of bomb attacks in recent years.
© Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Tuesday, 31 Mar 2015 14:05 PM
Chinese Foreign Minister Wang Yi left talks in Switzerland to seal an outline nuclear deal with Iran but his negotiating . . .
Sunday, 29 Mar 2015 20:51 PM
A major earthquake with a magnitude 7.7 struck off Papua New Guinea on Monday, official monitors said, and a tsunami war . . .
Sunday, 29 Mar 2015 09:51 AM
Tens of thousands of Singaporeans gave founding father Lee Kuan Yew a hero's funeral Sunday, ending a week of mourning i . . .
This serial criminal, like at least half the Democrat Party, belongs in federal...
Another disgusting betrayal of an ally by this Administration -- driven solely...
I don't feel anyone should be denied a seat at the Lunch counter..
But I do...
Iran is intent on destabilizing the Middle East to export its Shiite Revolution...
I was for gay rights, gay marriage. Not anymore. Now that I see how bigoted...
Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.


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25 Mar 2014
15 Apr 2013
I am actress, still trying to make my foothold strong in Bollywood. I had made a debut in Bollywood in 2004 but that went unnoticed and I moved on to south industry.
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List of Sudipta Chakraborty movies
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CFL Capital Financial Services has informed that Ms. Jostna Shrestha has been appointed as an Independent Woman Director of the Company in terms of... ...http://www.moneycontrol.com/news/announcements/cfl-capital-financial-services-outcomeboard-meeting_1347204.html
The Vatican on Wednesday signed a key agreement to exchange tax and financial information with Italy, both sides announced. It is the first of its... ...http://www.prokerala.com/news/articles/a540401.html
Markets finish the first session of FY15-16 on a firm note led by a strong rally in FMCG, healthcare, realty and financials stocks with Sun Pharma... ...http://www.rediff.com/money/report/how-the-markets-fared-on-apr-1/20150401.htm
In a major step to stem rampant corruption in public sector undertakings, the Central Vigilance Commission (CVC) has asked chairmen and managing... ...http://www.asianage.com/india/give-fraud-cases-cbi-pses-told-908
Posted by Equitymaster The NDA Government has set an ambitious target of developing 100 smart cities. However, as rightly quoted by the mayor of... ...http://feeds.equitymaster.com/~r/TheOutsideView/~3/TOJobnkk_F4/detail.asp
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Middlesboro Obituaries
Local obituary notices in Middlesboro, KY
Monday Mar 2 | via The Daily Standard
Jeanette Eldridge, 80, St. Marys, died at 5:08 p.m. Feb. 27, 2015, at Heritage Manor Nursing Home, Minster. She was born Dec. 1, 1934, in Pineville, Ky., the daughter of John L. and Myrtle Martin, who are deceased. Comment?
More local obituaries
Copyright © 2015 Topix LLC


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P-Mation #41: A-Door-Able
Blue boy meets his lovely neighbor!4.47 / 5.00 8,787 Views
Otherworld - Quiet Luke
in da othawurld4.43 / 5.00 5,026 Views
Joe vs the Environment
In collaboration with Earth Hour 2015 and Pocoyo4.07 / 5.00 2,335 Views
Way to GO
That is not normal!
that is some serious detail
Thats weard...BUT FUNNY!!!!!!!!!!
Good movie! Y like it!!! Wheres part#2 ??? :P
and totally unexpected
sooooo cool
ha ha i knew something was up when i read the description you are great
all I can say about this is...


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DEFINITION of 'Reserve Bank Of New Zealand'
The Reserve Bank of New Zealand is New Zealand's central bank and its overall purpose is to maintain the stability of New Zealand's financial system. The Reserve Bank of New Zealand is also responsible for maintaining monetary policy, meeting the currency needs of the public and providing support services for other banks. In 2007, New Zealand's government decided to expand the role of the Reserve Bank by increasing its regulatory oversight to include not only banks but also building societies, credit unions, insurance and finance companies.
INVESTOPEDIA EXPLAINS 'Reserve Bank Of New Zealand'
The Reserve Bank of New Zealand started operations in 1934 after the passing of the Reserve Bank Act of 1933. Unlike the United States Federal Reserve, the Reserve Bank of New Zealand does not have any private owners. It is entirely owned by the New Zealand government.
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What is the name of the currency in New Zealand?The New Zealand currency is known as the New Zealand dollar. The currency was decimalized in 1967, and divided into 100 parts ... Read Full Answer >>
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Registration is now open for the American Coatings Association's ACSeries: Coatings Regulations & Analytical Methods Conference, to be held May 14-15, 2013 at the Doubletree by Hilton Hotel & Suites in Pittsburgh, Pa. This one and one half-day conference is geared toward coatings industry professionals concerned with regulations and the analytical methods used for their development.
Register now to take advantage of the early bird rates until April 15, 2013!
Hotel Information
Doubletree by Hilton Hotel & Suites
One Bigelow Square
Pittsburgh, PA 15219
Phone: (412) 281-5800
ACA Room Rate: $169/night for single/double occupancy.
Hotel Cut Off Date - April 15, 2013. Mention ACA when making your reservation.
Registration Now Open for ACA's Coatings Regulations & Analytical Methods Conference
Published March 25, 2013
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