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England have suffered a blow ahead of their Four Nations campaign with Brisbane Broncos centre Jack Reed ruled out by a dislocated shoulder.
The 26-year-old Broncos star has now suffered similar injuries for the last three seasons - missing the 2013 World Cup campaign - and will undergo reconstructive surgery in an attempt to stop the problem recurring.
"He's dislocated his shoulder unfortunately and that's the third year in a row," Brisbane coach Anthony Griffin said.
"He'll probably have to have a reconstruction, which is disappointing for Jack, he's been in really good form."
Reed had scored a try in the game against Melbourne to bring the Broncos back into contention at 12-10 but after he was forced off the field following a heavy challenge at the end of the first half, the Storm pulled clear and won 22-12.
England kick off their Four Nations when they face Samoa in Brisbane on October 25.


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Effective Visualization
Effective interactive "live" and "post" processing needs to be flexible and dynamic. Scenes can be easily created and modified to examine your results. Scene content is flexible - you can illustrate surfaces of interest in your simulations and an extensive collection of derived parts, like the re-sampled volume (for Volume rendering), streamlines, and section cuts to name a few, gives you the ability to deeply interrogate your results. From a workflow standpoint, the task of composing a scene is simplified with our drag-and-drop functionality, letting you quickly display scalar and vector results. There's no limit to how many scenes you can create and scenes are dynamically updated while your simulation is running. This lends itself ideally to process automation – you can customize multiple scenes to illustrate your geometry, highlight your mesh, and provide multiple detailed views of your process variables. Annotations give you a way to place text, logos, plots and even other scenes into the same window letting you customize your postprocessing to exactly fit your needs.
A direct export from any scene produces files that are compatible with our free standalone 3D viewer, STAR-View+. The scene exports are much smaller in size than the simulation files they are derived from and this lets you easily share simulation results throughout your organization. STAR-View+ can be embedded in Microsoft PowerPoint giving you added options for communicating your results.
Interactive performance continues to be a core development area for us. With our current release, we have added the ability to cache sweep animations. With this, you will see much higher playback speeds and smoother interaction for the animated sweeping of iso-surfaces and plane sections.
Effective Analysis
Visualization provides qualitative insight to your simulations. The quantitative complement for comparison, validation and verification of your simulation results is delivered in three function categories: reporting, monitoring and plotting. Reports generally return a result based on the specification of a scalar and parts (including derived parts). Reports can be run interactively and provide the content for monitors which can be evaluated continuously during simulation runs. Reporting frequency is controlled with updating which can be triggered through several mechanisms. Monitor output forms the basis for monitor plots showing you how your reports change versus iteration or time step. Histogram and XY plots round out the plotting capabilities. As your simulation runs and the solution evolves, your data can be continuously interrogated and solver settings can be changed on the fly. This means that you are always in control, ensuring result accuracy and efficient computer resource usage.
Critical analysis of your simulation results needs to be easy and comprehensive. With this release, we are delivering a major update to our plotting capabilities. Better quality, an improved look, more control over legend placement and a new histogram plot type are just a few of the benefits. While our drag-and-drop functionality lets you add parts directly to any existing plot, we've also streamlined how data is managed - as a result, gathering and presenting data should be easier and faster. Finally, you can easily place plots into any scene giving you full flexibility to integrate and customize your reporting requirements.
Having the ability to standardize your analysis & reporting across many simulations is important. This can be done by creating re-usable templates. It is possible to further automate your process and capture your best practices using Java macros and our Simulation Assistant tool.

subset: commoncrawl


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Blackburn have confirmed striker Nikola Kalinic has left the club to join Ukrainian side Dnipro for an undisclosed fee.
Nikola Kalinic is on the brink of finalising his move away from Blackburn Rovers to join Ukrainian side Dnipro.
Blackburn boss Steve Kean is set to complete his first signing of the summer in the form of Radosav Petrovic.
The agent of Nikola Kalinic thinks it is impossible for the striker to play for Blackburn again.
Nikola Kalinic's agent has hit out at Blackburn for blocking his potential move to Ukrainian side Dnipro.
Out-of-favour striker Nikola Kalinic hopes his Blackburn future will be sorted out within days.
Skysports.com understands unsettled Blackburn striker Nikola Kalinic has handed in a transfer request.
Nikola Kalinic's agent claims his client is attracting interest and could be lured away from Blackburn.
Steve Kean is hoping for an end to the rumours which return with Nikola Kalinic from international duty.
Nikola Kalinic will look for a new club if he fails to force his way back into the Blackburn side.
Nikola Kalinic's agent insists the striker could leave Blackburn in the summer due to his lack of playing time.
Chris Samba feels Blackburn must see off Fulham this weekend if they are to start moving forwards.
Blackburn manager Sam Allardyce has praised Nikola Kalinic for again showing good composure.
Everton boss David Moyes believes Tim Howard will suffer no adverse impact from his blunder at Blackburn.
Sam Allardyce has paid tribute to his depleted defence following another clean sheet against Bolton.
Sam Allardyce fears he could ruin striker Nikola Kalinic's confidence should he throw him in at the deep end.
Sam Allardyce believes easing Nikola Kalinic into action will prove to be a wise decision in the long run.
Sam Allardyce claims Andriy Shevchenko's failings is why Nikola Kalinic has yet to be a Blackburn regular.
Blackburn forward Nikola Kalinic has said he is not physically ready to be called up to the Croatia U21 squad.
Blackburn boss Sam Allardyce is tipping Nikola Kalinic to be a success in the Premier League.
Watch every goal from every game in the Football League on your computer, mobile or tablet...


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Lazard Cost Savings on Track, Offsetting Weak M&A
NEW YORK (TheStreet) -- Lazard (LAZ - Get Report) shares were higher Friday despite weaker revenue in its advisory business, as the company's cost savings moves drew positive analyst reviews.
"Expense control was a bit better than we had expected thanks to some early payoff from management's ongoing cost savings initiative (with more in the way to come)," wrote Credit Suisse analyst Howard Chen following Lazard's first quarter earnings release before the market opened Friday.
Shares opened lower on Friday but were up 3.77% to $34.41 shortly before noon.
Lazard earned adjusted net income of $37 million, or 28 cents per share, compared to $45 million, or 33 cents per share a year ago. Revenue in the financial advisory business, which advises companies on M&A, capital raising, restructuring and other activities fell 39% vs. a year ago, while asset management revenue rose by 14%
KBW analyst Joel Jeffrey characterized management's view of the M&A market as more positive than that of Greenhill (GHL - Get Report), but less so than Evercore (EVR - Get Report) "with management citing a strong pipeline and major deal assignments but labeling the M&A environment as uneven," Jeffrey wrote. Cost savings have been a major focus for Lazard and Wall Street has been keeping a close eye on its progress in this area in particular following a major investment in the shares by Nelson Peltz's Trian Partners last year. Since Peltz disclosed a 5.1% stake in Lazard on June 15, shares are up nearly 50%, vs. 63% for Evercore, 37% for Greenhill and 19% for the S&P 500. During the first quarter, Lazard brought compensation and benefits expenses down to $248 million compared to $313 million a year ago, excluding charges in both periods. Lazard's ratio of compensation to operating revenue, which has been a major focus for management, fell to 60%, compared to 62.7% for the 2012 first quarter and 61.8% for the full-year 2012. Lazard aims to bring that ratio down "to the mid- to high-50s," according to a company press release. -- Written by Dan Freed in New York. Follow @dan_freedCheck Out Our Best Services for Investors
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Sweater Weather! Fend off the chill with a heavy does of style with this collection of designer Cardigans, Sweaters and Knits! You'll be able to weather anything in high style!
Why Emphatic? | Media | Testimonials | Shipping & Returns | Privacy Policy | Conditions of Use | Sitemap | Contact Us |


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Vitamin D Deficiency Center - Salem, ORWebMD Physician DirectorySalem, OregonVitamin D DeficiencyWhat is vitamin D?The "sunshine" vitamin is a hot topic. Should people be exposed to the sun for their vitamin D? Are the guidelines for how much vitamin D we need adequate? Is the tolerable upper limit too low? What benefits does vit... Other Related Vitamin D Deficiency ArticlesEmergency Contact for Salem
Nearby Salem Hospitals *Salem Hospital Psychiatric Medicine Center Salem Hospital Regional Rehab Oregon State Hospital West Valley Hospital Silverton Hospital Santiam Memorial Hospital Willamette Valley Med Ctr Samaritan Albany General Hosp Good Samaritan Regional Med Ctr Providence Newberg Med Ctr Samaritan Lebanon Comm Hosp Legacy Meridian Park Hospital *Provider Directory Terms of Use: The WebMD 'Provider Directory' is provided by WebMD for use by the general public as a quick reference of information about Providers. The Provider Directory is not intended as a tool for verifying the credentials, qualifications, or abilities of any Provider contained therein. Inclusion in the Provider Directory does not imply recommendation or endorsement nor does omission in the Provider Directory imply WebMD disapproval. |


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Automotive Digital Marketing ProCom
Professional Community for Car Dealers, Automotive Marketers and Sales Managers
What do your customers have to say about your service and collision centers? Let's find out and then capitalize on it. On this week's Hard Facts, Samantha explains how video can win you loyal customers.
Added by Paul Potratz on February 27, 2015 at 1:07pm — No Comments
Over my years in this business I have come to know Mark Tewart, Sean Stapleton and Joe Webb as the true friends and professionals they are in representing and caring about the success of auto dealers
In my opinion, just listening and learning from them alone is worth the price of admission to the Insight 15 Customer Loyalty & Retention Event. As someone who helped bring…
ContinueAdded by Mark Dubis on February 27, 2015 at 8:00am — 1 Comment
We've said it before, and we'll say it again: not all chat providers are the same. Vendor priorities vary, software technology can be user-friendly or not, not all providers hire chat teams within the US, and the quality of managed chat conversations are not equal.…
Added by Lisandra Ramos on February 27, 2015 at 7:48am — No Comments
In the world of business, it is very important if you know how to effectively use the right marketing technique. These days most of the businesses know the significance of using digital marketing or online marketing to promote products or…
ContinueAdded by Donald Heslop on February 27, 2015 at 4:52am — No Comments
Volkswagen is a name that identifies with super performance, reliability and advanced technology taken to life by advanced engineering techniques. While the German manufacturer has its name etched in golden words in the history of car manufacturing, its entry into the Indian market has allowed us to witness the launch of some spectacular mid-level vehicles, especially in the sweep of hatchbacks. Hence; if you are eyeing on some mid-range hatchbacks and sedans, you can defintely check out the…
ContinueAdded by Bella Edward on February 27, 2015 at 12:49am — No Comments
The very competitive automotive repair industry depends highly on sophisticated equipment which is very expensive. Automotive repair equipments like hydraulic lifts, alignment equipment etc play a vital role in the business operations of this industry. Although expensive, they are indispensable in various repair services. Therefore automotive repair equipment financing is assuming greater importance in the automotive repair industry.
The traditional lending institutions may not be…
ContinueAdded by JamesAndew on February 26, 2015 at 11:25pm — No Comments
The age of social media is upon the auto industry. The eloquence of a beautiful picture or carefully chosen words when shared with a community can exert a powerful influence. Influencers are proliferating in the auto world, bringing change in myriad ways. Automotive News spoke with a handful of them to learn…
ContinueAdded by Jody DeVere on February 26, 2015 at 2:00pm — No Comments
Scott Stratten, author of UnMarketing, UnSelling and other books. He shares some great insights that might be valuable to automotive digital marketers. Here is an interview from last fall's Content Marketing World event in Cleveland. You can view his video here at Carfolks.net……
Added by Mark Dubis on February 26, 2015 at 8:00am — No Comments
With almost everything consumers purchase, there's an owner's manual or set of instructions for them to use. For decades, car manufacturers have included an owner's manual with new vehicles. Sadly, it is no secret that this tidy three hundred-page booklet is one of the least read publications produced in mass…
ContinueAdded by Richard Holland on February 26, 2015 at 5:30am — No Comments
"We can't sell the cars for you, but we can help get you more opportunities."
I've heard that line dozens of times from many different vendors. I've actually said it myself at times over the last two decades on the vendor side of the automotive industry. Today, I'm here to tell you that it's not…
ContinueAdded by Tyson Madliger on February 25, 2015 at 5:42pm — No Comments
Knowing the difference between social media and social media advertising will save you thousands and help you sell more cars. On this week's Think Tank Tuesday, I explain what you need to know about developing an effective and comprehensive social media marketing strategy that will optimize your ROI and stop wasting money.…
ContinueAdded by Paul Potratz on February 24, 2015 at 1:24pm — No Comments
Urbandale, IA--February 24th, 2015--Flick Fusion (www.flickfusion.com) today announced it has released an upgraded version of its mobile apps for iPhone and Android devices. Lot service companies that provide auto dealers with inventory videos can now use mobile devices to shoot high-quality HD video, text or email videos to clients, extract images from videos and upload videos to websites, YouTube, Facebook and other third-party…
ContinueAdded by Brian Cox on February 24, 2015 at 9:01am — No Comments
Partnership means over 1,000 independent dealers will benefit from CarStory's unique reports, which are designed to build consumer confidence in used car purchasing process and to help dealers better engage customers online and on the lot
Austin, Texas - February 24, 2015 – CarStory, the industry's largest provider of crowdsourced data and analytics on used vehicle pricing…
ContinueAdded by Crystal Hartwell on February 24, 2015 at 8:44am — No Comments
6th Annual Texas Hold 'em Tournament Night Hosted at Route 23 Ford in Butler, NJ!
Route 23 Ford will be hosting the 6th Annual Charity Poker Tournament…
ContinueAdded by Jonathan Morales on February 24, 2015 at 8:18am — No Comments
If you still aren't sold on the importance of video marketing, it only takes a brief glimpse into recent news to illustrate just how important video is in marketing. There are many news stories relating to acquisitions, statistics and trends, which highlight the increasing importance – and value – that platforms of all…
ContinueAdded by Timmy D. James on February 24, 2015 at 5:00am — No Comments
Real-time data delivery improves customer service & retention opportunities for auto dealers
ALBANY, N.Y. – February 23rd, 2015 – Auto/Mate Dealership Systems (http://www.automate.com) today announced it has integrated its dealership management solution (DMS) with VinSolutions' (www.vinsolutions.com) all-in-one management, sales…
ContinueAdded by Mike Esposito on February 23, 2015 at 9:02am — No Comments
Hello and welcome to this week's Used Car Market Report with insights from Black Book and Ricky Beggs. Well, the word is officially out that Ricky Beggs' time at Black Book is limited. The final day will be April 1, 2015, and no, that is not an April Fool's joke.
Black Book will be producing a new report that will benefit you each and every week. It's called Black Book Market…
Added by Black Book on February 23, 2015 at 7:26am — No Comments
When will I see you again? No, I am not talking about the 70's pop song, although the lyrics just may fit the content here. I am talking about the continued trend in customer defections from our dealerships.
Customer's defect for many reasons and the longer an individual owns a car, the harder it can be…
ContinueAdded by Mike Gorun on February 23, 2015 at 6:00am — No Comments
Some might look at what we do in content, search, and social and wonder what in the world would drive us to be so pumped about a customer loyalty conference. After all, we don't offer loyalty programs or customer…
ContinueAdded by J.D. Rucker on February 22, 2015 at 6:30pm — No Comments
by Megan Duncan, Digital Solutions Consultant |
Thinking differently can cause some anxiety. Just ask Katie Couric & Bryant Gumbel circa 1994. Remember the Super Bowl commercial about the advent of the…
Added by CDK Global on February 20, 2015 at 2:00pm — No Comments
Welcome to
Automotive Digital Marketing ProCom
Please use the "Sign Up" link above to complete your registration form and become a member of the industry's leading Automotive Marketing and Internet Sales Professional Community. ADM members have access to resources, connections and private events that provide them with a competitive advantage.
ADMPC is a Network for Car Dealers, Automotive Marketing, Advertising and Management Pros sharing Digital Strategies and Execution Tactics.
March 5, 2015 from 12pm to 1pm – http://www.dealeron.com/webinar/events/industry-veteran-dissects-the-internet-3rd-parties-vendors/
0 Comments 1 LikeMarch 12, 2015 from 12pm to 1pm – http://www.dealeron.com/webinar/events/the-4-costly-follow-up-mistakes-you-can-fix-right-now/
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0 Comments 1 LikeMarch 24, 2015 to March 26, 2015 – Rosen Shingle Creek Resort | Orlando, FL
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0 Comments 0 LikesMarch 26, 2015 from 12pm to 1pm – http://www.dealeron.com/webinar/events/prospecting-data-mine-your-own-leads-generate-more-business/
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If IMDB is the best movie database on the net, then surely MJM Magic is the best online magic shop on earth! Not only the competitive price, lifetime...Read More ->
MJM has the best quality products, shipping is fast and customer service is always there to answer any questions you have. I have show stoppers that...Read More ->


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The latest comedy from Stephen Chow, CJ7 is a fantasy tale featuring state of the art visual effects. A poor laborer father (Chow) and his young son's lives are turned upside down when a fascinating and strange new pet enters their world. Amid the resulting comic mayhem, they ultimately learn a poignant lesson about the true nature of family and the things money can't buy.
List More Stephow Chow Series VCDs
Price: US$16.99
Price: US$34.95


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TD-Complete Submission
What to expect when you're expecting (an acceptance letter)
4.12 / 5.00 4,583 ViewsThis episode is where Sam gets moved to a different school because of his bad grades.
If your wondering the Kings school is a real place i like to take the piss out of :)
Sorry that this episode isn't so good :(
The background noise is very apparent, the animation is not very good, and the animation is WAY to loud upon arrival.
This was pretty cool! :) I also like how you put Eminem :] Maybe , you could have the movie go a bit slowere next time , as in take more time to progress the story :) Keep up the good work , and try to improve the animation a little. But I really liked it :)
Please stop making these.
No sorry mate i have another 8 episodes on the way but trust me they get better. I made this in early 2012 and I've improved so much since then. Give me a chance and you will see they get better. If you want to view them the please check my YouTube channel out http://youtube.com/animatedsam


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High power, premium appointments, and a stunning driving experience don't have to come at the expense of fuel economy. The Mercedes Benz S400 Hybrid is in a class all its own, combining all the luxury of the classic Mercedes S-Class with a n electric motor and lithium-ion battery for ultra-low emissions and sky-high efficiency. You get to enjoy all that Mercedes muscle while taking fewer trips to the pump and leaving a smaller footprint on Mother Nature. Plus, with all the Mercedes S400 accessories you'll find here, you can enjoy a comfortable ride, top-notch looks, and performance to boot.
Since making it's introduction in 2007, the Mercedes-Benz S400 is an extraordinary luxury sedan. That's why when you browse our website, be rest assured that we absolutely carry the top name brands in S400 automotive parts & accessories. If you're indecisive about the best Mercedes-Benz S400 aftermarket part, talk with any of our knowledgeable product experts team - we're available every day of the week to help in finding you the perfect performance parts for your ride. The best part is, every part is supported by an industry-leading One-Year Price Match Guarantee, and ships one-hundred percent free of charge. Interior upgrades such as floor mats or custom seat covers excellently beautify your S400's features, while exterior components such as cargo carriers and car bras improve your vehicle's profile.


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Tag: carbonite
Transporter: Network attached storage with flair
The Transporter from Connected Data offers a new generation of network-attached storage (NAS). This technology allows you to connect a hard drive to your router, access it from anywhere and share its stored files. It is a bring-your-own drive alternative to the cloud. Units cost US$199 for a ...
No comment: Steve Jobs in Carbonite
Did you ever wonder what happens when the reality distortion field meets Star Wars? You get these cool/cheesy/ready-for-cease-and-desist Steve Jobs in Carbonite iPhone skins and cases from Society6. Until the Apple lawyers get ahold of this and breathily note "I am altering our agreement. Pray ...
World Backup Day: Mozy app puts backed-up files at your fingertips
Here's another product for World Backup Day. Mozy, a well-respected and veteran cloud backup solution for Mac and PC, has delivered Mozy to the App Store. This app, which is a free download that works with any iOS device, gives you access to all of those files from your computer that have been bac...
Mac 101: Backup basics with Time Machine and more
Did you get a new Mac for Christmas? Before you go too far in loading your Mac with software and files, make sure that you have a backup strategy. As a certified Mac consultant, I can tell you that there are two kinds of computer users: those who have lost data through error, hardware failure, or ac...
Ask TUAW: Automatic file sorting, Disk Utility, iPod battery replacement, and more
Welcome back to Ask TUAW, our weekly troubleshooting Q&A column. This week we've got questions about automatically sorting downloaded files, using Disk Utility to change partitions and format external drives, using a KVM in a multi-platform environment, replacing an iPod touch battery, and more....
Ask TUAW: Online backup, Bluetooth with iPod touch and OS 3.0, converting DVDs for iPhone, and more
In this round of Ask TUAW we've got questions about connecting a MacBook to a plasma TV, using a Bluetooth headset with an iPod touch, backing up online, ripping DVDs to watch on an iPhone and more. As always, your suggestions are welcome. Questions for next week should be left in the comments. W...
Software Updates
more updates- Apple Remote Desktop updated with Yosemite support
- OS X Yosemite 10.10.2, iOS 8.1.3 updates now available
- Sports Illustrated 120 SPORTS channel comes to Apple TV
- Logic Pro X update brings AirDrop support, new effects, tools, and more
- Parallels Access 2.5 released, adds file manager, computer-to-computer remote access
- The Google Translate iOS app is about to get a lot smarter


text: Mass Effect 3 Endings ExplainedEDIT - There's even a video to help explain it: http://www.youtube.com/watch?v=UDSwW7jflAQ&feature=youtu.be EDIT PART 2 - Here's an even better video to explain it: http://www.youtube.com/watch?vZ7bsIpEKIgEDIT PART 3 - Here's a link to the BSN Thread with more details: http://social.bioware.com/forum/1/topic/355/index/9727423EDIT PART 4 - Here are some images that help make more sense:http://i.imgur.com/DkXPT.jpg ***********************************"You take the blue pill - the story ends, you wake up in your bed and believe whatever you want to believe. You take the red pill - you stay in Wonderland and I show you how deep the rabbit-hole goes." Doesn't this sound oddly familiar?By picking the blue or green options in Mass Effect 3, you basically agreed to give up, stop fighting and just die. Picking the red beam means your still fighting, struggling against the Reapers, not going to just lay there and die like they want you to. Live to fight another day..


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CarouselShop Registered: 25 August 2009 Feedback: 0% positive feedback over the last 12 months Location: UK Visit Store Contact Merchant
0% Positive Feedback *Based on last 12 months ratings Feedback Summary 1 month 6 month 12 month Lifetime Positive % 0% 0% 0% 90% Positive 0 0 0 118 Neutral 0 0 0 1 Negative 0 0 0 13 Total 0 0 0 132
Merchant Feedback History Results 1 – 50 (of 132) Feedback Comment Buyer Date Positive brilliant x cookiemother 27 March 2013 Positive Excellent Seller Marxwax 02 March 2013 Positive ace andyjoh 21 January 2013 Positive Very well packaged. Thank you. Ironflyaway 27 December 2012 Positive Great gift, bought as a novelty, but is actually very good quality item, and furthermore, quality service / delivery by seller! skymanhoff 22 December 2012 Positive my grandson loves it, and quick delivery juneyfant 20 December 2012 Positive Great service. Product arrived on saturday vickerstuff 11 November 2012 Positive Speedy, good service. MichaelSR2 05 October 2012 Positive quick delivery thank you jacqui46 20 August 2012 Positive Very fast delivery, well impressed. mikeb1671 19 July 2012 Positive many thanks very good angelcakes123 07 July 2012 Positive good item thanks hpark27 23 December 2011 Positive Ordered on Monday, delivered in Guernsey Thursday. I am very happy, item is exactly as shown and in perfect condition. I will have a very happy son on Christmas Day! guernseyborn 08 December 2011 Positive Very well packaged, and arrived super quick, many thanks :) Babyt1977 11 November 2011 Positive arrived on time excellent service jordy99 08 October 2011 Positive arrived on time as desscribed. jordy99 08 October 2011 Positive Highly recommended. A++++++ jv1962 06 October 2011 Positive excellent many thanks luke08liam10 13 September 2011 Positive sorry it took to long com has been down but yes the game was in excellent con and very fast delivery A********* will deal with agane vespamad 08 September 2011 Positive Product and shipment exactly as said, item received in 2-3 working days. Recommended seller. glennmiller13 24 August 2011 Negative Very disappointed to find out they refunded my order with no details on why. looks like my 6 month old has to wait a while longer for her toy. Disappointedandsad 23 August 2011 Positive Very quick delivery & product exactly as described. Would definitely use again :) DFawkes 15 August 2011 Positive nice item in working order thanks REDDEVILXVI 24 March 2011 Negative I ordered an item from "CarouselShop" and 6 weeks later after being told it had been sent, I have still not received the item or a reply to the numerous emails I sent directly to them and though play.com to query the item. Stay away from this seller. SonofMcClane 11 March 2011 Negative took nearly two weeks to come no feedback! chrismuldutch 10 March 2011 Negative I never recieved the product. After waiting a few weeks from the posted date, I emailed the supplier as to the products whereabouts and recieved no reply. No help and no product blissmiss 09 March 2011 Positive Order arrived very quickly and was as expected. Well done! dinosaurlover 21 January 2011 Negative Problem with game but cannot get carousel customer services to answer emails. wiggieworks 18 January 2011 Positive Came much more quickly than any of the things I ordered direct from Play, recipient loved it, thank you! bethnoble 12 January 2011 Positive Happy with purchase, recieved within delivery estimated Ivers08 08 January 2011 Positive Fast delivery. Thanks blackbetty30 29 December 2010 Positive I want this - don't want to put it in my son's stocking!! Arrived promptly and more imprtantly before Christmas - despite the weather - thanks! kurgan27 21 December 2010 Negative The wrong item was delivered.I ordered the fire dept theme but radiator springs was delivered. The item is a Christmas present & time is critical. Crimoelf 17 December 2010 Positive brilliant thank you darthmaul 15 December 2010 Positive As described - speedy delivery - thankyou shelleyissy 07 December 2010 Positive Arrived 2 days after postage, no hassle at all and an easy transaction franco072 26 November 2010 Positive exellent cherie26 02 November 2010 Positive Excellent item and quick delivery 5***** would highly recommend thanks ronny79 27 October 2010 Positive Quick WendyT 15 October 2010 Positive Great item and good communications. Very happy, thank you! Twink1eToes 05 October 2010 Positive A Great game and a great service. Came within 2 days of ordering, Recommended to all "Player.comers" and all Gamers HenryTheHoover 03 September 2010 Positive Well packaged, delivered promptly. bixbarton 12 July 2010 Positive Quick payment Quick delivery Product sealed, as new. Strongly recommend using this seller. A+ AshDaMash 01 July 2010 Positive on time and in perfect condition :) nattsplat 27 June 2010 Positive it came well packaged and in great condition but was a little late will use again as a last resort Alexmaximus 14 May 2010 Positive EXCELLENT QUICK DELIVERY LAURASMYTH 12 May 2010 Negative you sent the wrong game waqi786 01 May 2010 Positive Item arrived, well packaged and delivered quickly. Would use again GHurley 29 April 2010 Positive Got in post safety, fast devilery. Thank You. SmexyZackFair 22 April 2010 Positive this came nicely boxed and as advertised with the box in good condition and in original pcaging , the post was also good , many thanks. markfree 08 April 2010


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Seattle Seahawks Gear
Seattle Seahawks T-Shirts
Seattle Seahawks T-Shirts Mens
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Product ID: 1653585
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The Seattle Seahawks are headed to Super Bowl XLVIII. Celebrate your Seahawks with this Heart and Soul Super Bowl Bound tee. It boasts Seattle and Super Bowl graphics on the front, so your team pride will be on full display.
- High-quality team graphics
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Sunday, June 30, 2013 - 11:29am
Huntington, Texas (KETK) — A motorcycle crash ends with one dead Saturday afternoon.
It happened just after 4:00 p.m. on Farm to Market Road 1818 just an eighth of a mile from U.S. Highway 69.
A motorcycle driven by William Arthur Harrison, 72, of Huntington was driving north bound on Farm to Market Road 1818 when he failed to negotiate a turn and lost control of his vehicle.
Harrison was pronounced dead at the scene by Justice of the Peace, Brad Stringer.
Upon further investigation it was found that Harrison was not wearing a helmet at the time of the crash.
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The Grompe laboratory at Oregon Health & Science University has an opening for a postdoctoral scientist to work on in vivo gene targeting in the liver. Gene targeting will be used to correct genetic defects in hepatocytes in situ as well as introduce tumor causing mutations. Chimeric mice with humanized livers will be used throughout the work, enhancing its translational relevance.
Molecular biology experience is desired.
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Ken Zaret, PhD, featured in the latest issue of Nature.
Harvard Stem Cell Institute (HSCI) scientists at Beth Israel Deaconess Medical Center, in collaboration with researchers at the University of Pennsylvania, have a new theory for why early immune cells hang out in the developing embryo, despite the low odds of infection.
Ben Stanger, MD, PhD featured in Cell Stem Cell article, "Liver Stem Cells, Where Art Thou?"
Roberto Bonasio received the National Institute of Health prestigious New Innovator Award, see the full story here.
For the first time and to start the seminar year, the Stem Cell Club hosted investigators from outside the Penn community. On September 17, Christoph Lepper, PhD, from the Carnegie Institute for Science, spoke to a standing-room-only crowd at the Institute for Regenerative Medicine. His lecture on "Age Dependent Genetic Regulation of Skeletal Muscle Stem Cells" prompted an active discussion session.
Foteini (Faye) Mourkioti, PhD, from the departments of Orthopedics at the Perelman School of Medicine, was able to fit in her lecture before traveling down the elevator to be welcomed by the Dean of the Medical School at a New Faculty event in the same building! Faye's lecture on "Muscle Stem Cells in Disease Modeling" completed the late-afternoon event focused on muscle stem cells.
The Institute of Regenerative Medicine is looking forward to the next event, when Michael Rendl, PhD from Mt. Sinai Hospital will speak in "Sox2 in the Niche is the Key Regulator of Hair Growth" and Todd Ridky, MD, PhD and Penn Department of Derrmatology and Cell and Molecular Biology Faculty member, will speak on "Mechanisms Driving Proliferation Arrest in BRAF Mutant Melanocyte Nevi." Please come Oct 22, 2014 at 4:00 pm for the next Stem Cell Club.
The liver is one of the tissues with the highest capacity to regenerate in the body. Indeed, the Greek myth of Prometheus is an advertisement for this extraordinary ability, as the Titan's liver was eaten daily by an eagle only to regrow each night for the cycle to repeat itself. And knowing exactly how this quick turnover occurs in the liver might help patients with such diseases as cirrhosis, hepatitis, and cancer. Read More By Karen Kreeger, Penn Medicine Communications
Ed Morrissey, PhD, IRM Scientific Director and Director of IRM Program in Lung Regeneration and Repair, recently published a paper in Cell, Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function. Read the full text here.
This announcement is also available online at:
PHILADELPHIA — Kenneth S. Zaret, PhD, a nationally recognized leader in the fields of developmental and stem cell biology, has been named the new director of the Penn Institute for Regenerative Medicine (IRM). Zaret, who was the IRM associate director, is also the co-director of the Epigenetics Program in the Perelman School of Medicine at the University of Pennsylvania.
Established in 2006, IRM is a locus for interdisciplinary research involving faculty from more than 25 departments in five schools to advance the field of regenerative medicine. As IRM associate director, Zaret worked with John Gearhart, PhD, first director of the IRM, and Ed Morrisey, PhD, IRM scientific director, to establish IRM as a national leader in the field.
"I am confident that Dr. Zaret will bring his solid knowledge and experience in developmental and stem cell biology, as well as epigenetics, to lead the Institute for Regenerative Medicine into its next chapter of research, education, and clinical advances," said J. Larry Jameson, MD, PhD, dean of the Perelman School of Medicine and executive vice president of the University of Pennsylvania for the Health System.
"In the next phase of the Institute, I aim to coalesce new discoveries, technologies, and ethical perspectives to create important scientific and clinical advances, especially in the areas of digestive tissue regeneration, cancer diagnosis and targeting, and skin repair, with additional focus on musculoskeletal, nervous system, and cardiovascular repair," said Zaret.
He earned his PhD degree from the University of Rochester Medical School and completed his postdoctoral training in the Department of Biochemistry at the University of California, San Francisco. Before joining Penn in 2009 as the Joseph Leidy Professor in the Department of Cell and Developmental Biology, he was a Senior Member of the Cell and Developmental Biology Program at the Fox Chase Cancer Center, where he held the W. W. Smith Chair. Prior to that, Zaret was on the faculty of the Brown University Medical School.
The goal of his research program has been to understand how genes are activated to specify different cell types during embryonic development. Zaret's lab discovered a basis for the normal path of development in different tissue types by identifying pioneer transcription factors that engage target genes in progenitor cells, early in the development process. He established the use of mammalian embryonic endoderm cells as an experimental system and used them to discover signals that induce liver and pancreas tissue in the embryo. These discoveries are now used by others in regenerative medicine to identify specific types of stem cells for therapies and research.
His lab discovered that endothelial cells possess a direct signaling role in promoting liver and pancreas development, a finding that colleagues use to enhance artificial organ development. While investigating the basis by which cells resist being reprogrammed, the Zaret lab also found large areas on chromosomes that physically block the binding of regulatory factors, which must be overcome to allow cell reprogramming.
Recently, his lab used stem-cell technology to reprogram human pancreatic cancer cells to develop an experimental model to recreate and study early stages of the disease.
Zaret has written or cowritten nearly 100 peer-reviewed research articles, as well as numerous book chapters. He has been an editor of the journals Molecular and Cellular Biology and Development; chaired international scientific meetings; and served on numerous scientific advisory boards for academia, biotech/pharma, and the National Institutes of Health, including the National Institute of General Medical Sciences (NIGMS) Council.
Among numerous professional accolades, he has received a MERIT award from NIGMS, the Hans Popper Basic Science Award from the American Association for the Study of Liver Diseases and the American Liver Foundation, and is a Fellow of the American Association for the Advancement of Science.
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2013 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2013, Penn Medicine provided $814 million to benefit our community.
This article is available online at:
Penn study points to new mechanisms of tissue development and origins of congenital lung disorders
PHILADELPHIA — It's a long way from DNA to RNA to protein, and only about two percent of a person's genome is eventually converted into proteins. In contrast, a much higher percentage of the genome is transcribed into RNA. What these non-protein-coding RNAs do is still relatively unknown. However, given their vast numbers in the human genome, researchers believe that they likely play important roles in normal human development and response to disease.
Large-scale sequencing has allowed investigators to identify thousands of non-coding RNAs. Small non-coding RNAs, including microRNAs, are known to be important players in regulating gene expression in many contexts, including tissue development. On the other hand, the function of long non-coding RNAs (lncRNAs) is less well understood.
Research led by Ed Morrisey, PhD, professor of Medicine and Cell and Developmental Biology in the Perelman School of Medicine, University of Pennsylvania and scientific director of the Penn Institute for Regenerative Medicine, has identified hundreds of these lncRNAs, sometimes called the "genomic dark matter," that are expressed in developing and adult lungs. Their findings, described in and featured on the cover of the current issue of Genes and Development, reveal that many of these lncRNAs in the lung regulate gene expression by opening and closing the DNA scaffolding on neighboring genes.
The team identified 363 long non-coding RNAs in the lung of the embryonic and adult mouse. They show that these lncRNAs are often located near transcription factors in the genome of lung cell lineages. "We have defined a new association of long non-coding RNAs with proteins called transcription factors that bind to specific DNA sequences and control cell identity and function," Morrisey says. "This association is important for lung development in mouse embryos, and at least for one of these long non-coding RNAs, important for human lung function."
Critical Pathways for Development, Disease
The team identified a lncRNA, called NANCI, that regulates the critical transcription factor Nkx2.1. This factor is the first lung molecular marker during mouse and human development and is essential for lungs to mature properly in an embryo.NANCI appears to act upstream of Nkx2.1, but down-stream of Wnt signaling, a critical pathway for specifying cell type later in lung tissue development. Knockdown of NANCI expression during lung development leads to decreased Nkx2.1 expression and mimics the defects due to loss of a single copy of the Nkx2.1 gene, including decreased expression of surfactant proteins. These proteins aid in marking bacteria invading the lung for destruction by the immune system.
Importantly, patients with mutations in a single copy of NKX2.1 often have Brain-Lung-Thyroid Syndrome, which is characterized by respiratory distress after birth and accompanied by decreased surfactant protein expression. "There is also a report of a patient with a deletion in NANCI but not NKX2.1 who has Brain-Lung-Thyroid Syndrome, suggesting that mutations in NANCI and other lncRNAs can underlie human diseases," explains Morrisey.
In addition to NANCI, the team identified another lncRNA, which they named LL34, that regulates retinoic acid signaling, another important pathway for early lung development. LL34 is highly expressed in the early developing foregut, a region of the embryo that generates multiple tissue types, including lung, thyroid, and liver. Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.
While other lncRNAs expressed in the lung, such as MALAT1, may primarily play a role in cancer progression, the data generated by the Morrisey lab provides unique insight into lncRNAs that regulate lung development. "We are hopeful that these new data provide the foundation for a better understanding of how the non-coding transcriptome regulates tissue development and also maintenance of adult tissues," says Morrisey.
Future work will be directed towards understanding how these lncRNAs control lung development, as well as adult lung regeneration using both mouse and human model systems.
Additional coauthors are Michael J. Herriges, Michael P. Morley, Komal S. Rathi, Tien Peng, and Kathleen M. Stewart, all from Penn and Daniel T. Swarr, from The Children's Hospital of Philadelphia.
Studies in the Morrisey lab were supported by funding from the National Heart, Lung and Blood Institute (HL100405, HL110942).
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2013 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2013, Penn Medicine provided $814 million to benefit our community.
On April 11, 2014 the Institute hosted a Symposium on Cellular Reprograming honoring John Gurdon, the 2012 Nobel Laureate in Physiology and Medicine.
Dean J. Larry Jameson opened the conference and John Gurdon presented the Keynote Address on Past, Present and Future Prospects for Nuclear Reprogramming by Amphibian Eggs and Oocytes.
Kathrin Plath (UCLA) and Ken Zaret presented studies on the mechanisms and steps involved in the programming and reprogramming of pluripotency; Nancy Speck illustrated lessons from the embryo through her work on hematopoietic stem cell formation and Jim Eberwine emphasized the importance of gene expression variability with his studies of functional single cell genomics. Young investigators Kilang Yanger and Russ Addis presented their research on reprogramming in the adult liver and forced transdifferentiaton of fibroblasts to cardiomyocytes, respectively. George Cotsarelis presented the final talk on the basic science of stem cells in the hair bulb and the progress to the clinic.
Nicholas Wade, a science journalist with the New York Times, provided the audience with an objective and practical perspective on the coverage of the stem cell story (which he had covered since the '90's) emphasizing the need for circumspection on claims and the importance of strategies for informing the public on science.
Click here to view symposium photos.
By John George, Philadelphia Business Journal
Dr. John Gearhart, director of the University of Pennsylvania Institute for Regenerative Medicine in the lab with Jamie Ifkovits, Ph.D.
Inside Life Science
Sharon Reynolds
Posted January 8, 2014
Normally, when a cell becomes damaged or doesn't divide properly, the body's natural recycling process breaks it down and it dies. Sometimes, though, the damage is to the genes that control a cell, and the result is out-of-control division. When this happens, a cancer cell is born.
New insights into how cancer cells arise and develop into tumors have come from researchers funded by the National Institutes of Health. Some of them are exploring the process by studying stem cells.
Modeling Early Pancreatic Cancer
Despite decades of progress in the detection, treatment and prevention of many types of cancer, the long-term survival rate for pancreatic cancer remains very low. One reason is that pancreatic cancer rarely produces symptoms until it has spread in the body.
The late stage at diagnosis also poses problems for researchers who want to study the early development of pancreatic cancer, according to Kenneth Zaret of the University of Pennsylvania School of Medicine. That's because pancreatic cancer cells taken from people and then used to form tumors in animal models immediately produce the aggressive, advanced cancers from which they were derived.
Zaret's lab has focused on understanding how transcription factors—proteins that control which genes in a cell are expressed—work in stem cells. His team recently explored the idea of reprogramming cancer cells so they act like embryonic stem cells, which can become just about any type of cell in the body. Because transcription factors in embryonic stem cells guide early organ development, the researchers thought that forcing cancer cells back to an embryonic state might allow the transcription factors to reproduce the early stages of cancer. This could then provide a model for studying the early development of pancreatic cancer.
Using tumor tissue from people with pancreatic cancer, Zaret and his colleagues succeeded in turning a sample of cancer cells back to an early, stem cell-like state. When used to create tumors in mice, these so-called induced pluripotent stem (iPS) cells formed early stage tumors and slowly progressed to invasive disease.
The human tumors grown in mice also secreted a wide range of proteins that are indicative of cell networks known to drive pancreatic cancer progression, as well as some not previously known to be associated with the disease. "We're setting up collaborations to test these markers for their utility in screening human blood samples and see if they function as markers for detecting or predicting pancreatic cancer in humans," said Zaret.
Scientists are also interested in using the iPS cells to screen new anticancer compounds and determine whether drugs under development might have the potential to help treat early stage pancreatic cancer.
Unraveling Cause and Effect in a Precursor to Esophageal Cancer
Like pancreatic cancer, esophageal cancer, which can begin anywhere in the muscular tube that runs from the throat to the stomach, has a low long-term survival rate. But unlike pancreatic cancer, research has produced insights into how to reduce the risk of developing esophageal cancer, including quitting smoking, reducing alcohol consumption and monitoring a potential precursor condition called Barrett's esophagus.
In Barrett's esophagus, the cells that line the lower esophagus, called epithelial cells, slowly change to resemble abnormal stomach or intestinal cells. The condition eventually progresses to esophageal cancer in up to 10 percent of cases. Scientists want to better understand the cellular mechanisms driving Barrett's esophagus to find ways to help treat it or prevent it from occurring and progressing to cancer.
The most common explanation for how Barrett's esophagus begins is that an excess of stomach acid, produced by conditions such as acid reflux (heartburn), washes up into the esophagus and causes tissue damage that leads to the production of the abnormal cells seen in the disease. Consequently, acid-reducing drugs are often prescribed to people with Barrett's esophagus to help slow its progression. However, new research from the lab of Heinrich Jasper at the Buck Institute for Research on Aging suggests an alternative explanation for the cellular changes seen in Barrett's esophagus.
Jasper's lab explores how stressful conditions affect the function of adult stem cells, which can become specialized tissue or organ cells. While looking at how stem cells control the regeneration of the gastrointestinal tract in a type of fruit fly, Jasper made an unexpected discovery: When a cell-signaling pathway driven by a protein called Dpp goes awry, it causes the stem cells that normally create the lining of the esophagus (the esophageal epithelium) to instead produce acid-generating stomach cells within the esophagus.
"What happens in Barrett's esophagus is really quite similar to what we observed [in fruit flies], which was a transformation of esophageal epithelium into something more like gastric epithelium," said Jasper. In other words, cellular changes in the esophagus may actually drive the excess production of acid rather than the other way around.
Jasper's lab is now working with collaborators at the University of Rochester to investigate this process in a mouse model of Barrett's esophagus. If something similar occurs in people, an understanding of errors in stem cell signaling might lead to the development of new treatments for Barrett's esophagus and the prevention of esophageal cancer.
Throughout the country, NIH-funded researchers continue to explore how our cells work normally and how they malfunction in disease. What scientists learn using stem cells, model organisms and a wealth of other approaches could help promote health as well as the diagnosis, treatment and prevention of diseases like cancer.
This release is available online at:
Manipulation of the Wnt/β-catenin Signaling Pathway Could Provide Therapeutic Targets for Hair Loss, Unwanted Hair Growth and Skin Cancer
PHILADELPHIA — A pathway known for its role in regulating adult stem cells has been shown to be important for hair follicle proliferation, but contrary to previous studies, is not required within hair follicle stem cells for their survival, according to researchers with the Perelman School of Medicine at the University of Pennsylvania. A new study, published in Cell Stem Cell, identifies a molecular pathway that can be activated to prompt hair growth of dormant hair follicles, or blocked to prevent growth of unwanted hair.
The team examined the functions of Wnt proteins, which are small molecular messengers that convey information between cells and activate signaling via the intracellular molecule β-catenin. By disrupting Wnt signaling in an animal model with an inhibitor Dkk1, the team found that hair growth was prevented. However, stem cells were still maintained within the dormant hair follicles. When Dkk1 was removed, the Wnt/β-catenin pathway resumed normal function, the stem cells were activated, and hair growth was restored.
The team also unexpectedly found that the Wnt/β-catenin pathway is normally active in non-hairy regions, such as on the palms of hands, soles of feet and the tongue, as well as between hair follicles on the surface of the skin. This finding is consistent with previous results showing that removing β-catenin prevents growth of skin tumors.
"While more research is needed to improve our understanding of this pathway, our results suggest that therapeutics capable of decreasing levels of Wnt/β-catenin signaling in the skin could potentially be used to block growth of unwanted hair, and/or to treat certain skin tumors. Conversely, if delivered in a limited, safe and controlled way, agents that activate Wnt signaling might be used to promote hair growth in dormant hair follicles in conditions such as male pattern baldness," said senior author Sarah Millar, PhD, professor in the departments of Dermatology and of Cell and Developmental Biology.
Researchers aim to better understand the key components and functions of the Wnt/β-catenin pathway. Important areas of focus for future work will include developing effective means of safely targeting therapeutics to the skin for clinical and cosmetic applications.
The research team includes co-corresponding author Edward E. Morrisey, PhD, professor of Medicine, along with co-first authors Yeon Sook Choi and Yuhang Zhang, and Mingang Xu, Mayumi Ito, Thomas Andl, and George Cotsarelis from Penn's department of Dermatology; Tien Peng and Zheng Cio from Penn Cardiology; and colleagues from the University of Cincinnati, Cincinnati Children's Hospital Medical Center, Mount Sinai Hospital in Toronto, and Sloan Kettering Institute in New York.
The research was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R37 AR47709 and P30 AR057217).
This release is available online at:
PHILADELPHIA – The evolution of adaptations for life on land have long puzzled biologists – are feathers descendents of dinosaur scales, how did arms and legs evolve from fins, and from what ancient fish organ did the lung evolve?
Biologists have known that the co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to life outside of water, coupling the function of the heart with the gas exchange function of the lung. And, the lung is one of the most recent organs to have evolved in mammals and is arguably the most vital for terrestrial life.
The coordinated maturation of the cells of these two systems is illustrated during embryonic development, when the primitive lung progenitor cells protrude into the primitive cardiac progenitor cells as the two organs develop in parallel to form the cardiopulmonary circulation. However, little is known about the molecular cues guiding this simultaneous development, and how a common progenitor cell for both organs may influence the pathology of such related diseases as pulmonary hypertension.
In a new paper published this week online in Nature, a team from the Perelman School of Medicine, University of Pennsylvania, shows that the pulmonary vasculature, the blood vessels that connect the heart to the lung, develops even in the absence of the lung. Mice in which lung development is inhibited still have pulmonary blood vessels, which revealed to the researchers that cardiac progenitors, or stem cells, are essential for cardiopulmonary co-development.
The Penn team, led by Edward E. Morrisey, PhD, professor of Medicine and Cell and Developmental Biology and scientific director of the Penn Institute for Regenerative Medicine, identified a population of multi-potent CardioPulmonary mesoderm Progenitor cells they named CPPs. The CPPs can be distinguished from many other early embryonic cells by the expression of a well-studied signaling molecule Wnt2.
"We asked if these progenitor cells are capable of generating both heart and lung derivatives," says Morrisey. "Our data show that Wnt2-positive cells exist prior to lung development and help coordinate lung and heart co-development by generating cell types in both tissues."
The issue of how the lung develops and connects to the cardiovascular system has intrigued the Morrisey lab for many years. "It's pretty obvious to anyone who has looked at the anatomy of most terrestrial animals that the heart and lung are intimately linked. This is even reflected in clinical medicine where in many places, including the Perelman School of Medicine, the Division of Cardiovascular Medicine was once referred to as the Division of Cardiopulmonary Medicine," notes Morrisey.
The Morrisey lab began with a couple of simple questions: how do the lung and heart co-develop and what are the critical signals that regulate this process? The breakthrough in this work occurred when the team characterized the expression pattern of the Wnt2 gene.
"Wnt2 is expressed in a unique place in the early embryo -- exactly in between the early heart and foregut tube, where the lung will arise from." This allowed the researchers to create a model system in mice, whose cardiopulmonary anatomy is very similar to humans, and ask whether Wnt2-positive cells could coordinate heart and lung co-development.
Using cell lineage tracing analysis, they showed that Wnt2 cells generate single clones that, in turn, generate both heart and lung tissue, including cardiomyocytes and blood vessel cells such as vascular smooth muscle. Indeed, CPPs are capable of generating the vast majority of early embryonic cell types in the heart and lung. These studies also showed that the different cell lineages within the lung are related. For example, vascular smooth muscle and airway smooth muscle share a common progenitor cell in the lung.
The development of CPPs is regulated by the expression of another well-known protein called hedgehog, which is required for proper connection of the pulmonary vasculature to the heart. These studies show that hedgehog, which is also expressed by early lung progenitor cells, helps to promote CPPs to differentiate into the smooth muscle component of the pulmonary vasculature.
Together, these studies identify a novel population of multi-potent cardiopulmonary progenitors that coordinate heart and lung co-development, which is required for adaptation to terrestrial existence.
The finding that CPPs coordinate lung and heart co-development also has important implications for diseases that affect both organs, such as pulmonary hypertension. It is unclear whether pulmonary hypertension is primarily a lung disease or whether there are also intrinsic defects in the heart or cardiovascular system. The identification of CPPs could provide important insight into pulmonary hypertension and other diseases by identifying a common progenitor cell for both organs. Future studies will focus on whether CPPs exist in the adult cardiopulmonary system and whether they play a role in the response of the lung and heart to injury or disease.
Co-authors are Tien Peng, Ying Tian, Cornelis J. Boogerd, Min Min Lu, Rachel S. Kadzik, Kathleen M. Stewart, all from Penn, and Sylvia M. Evans, University of California, San Diego.
This work was funded by the Heart, Lung and Blood Institute (HL110942, HL100405, HL087825, HL117649) and the American Heart Association Jon DeHaan Myogenesis Center.
This release is available online at:
Markers Discovered in Initial Stages of Disease Could be Used for Early Detection, Treatment, Prognosis
PHILADELPHIA — Pancreatic cancer carries a dismal prognosis. According to the National Cancer Institute, the overall five-year relative survival for 2003-2009 was 6 percent.
Still, researchers and clinicians don't have a non-invasive way to even detect early cells that portent later disease. 'There's no PSA test for pancreatic cancer,' they say, and that's one of the main reasons why pancreatic cancer is detected so late in its course.
They have been searching for a human-cell model of early-disease progression. Now, Perelman School of Medicine, University of Pennsylvania scientists have used stem-cell technology to create a research cell line from a patient with advanced pancreatic ductal adenocarcinoma (PDAC).
This first-of-its-kind human-cell model of pancreatic cancer progression was published this week in Cell Reports from the lab of Ken Zaret, PhD, professor of Cell and Developmental Biology.
"It is the first example using induced pluripotent stem [iPS] cells to model cancer progression directly from a solid tumor, and the first human cell line that can model pancreatic cancer progression from early to invasive stages," says Zaret, also the associate director of the Penn Institute for Regenerative Medicine.
"We were able to predict the appearance of cellular features and protein markers in the intermediate stages of pancreatic cancer that are not evident in the terminal stages. This has given us new perspectives into what this deadly type of cancer looks like – something no one has seen before in human cells. Our analysis revealed known molecular networks that are activated during PDAC progression, as well as a new molecular network that is activated during the intermediate stages. This could provide a fresh outlook on biomarkers for early stages of the disease."
A Leap of Faith
Zaret and first author Jungsun Kim, PhD, a postdoctoral associate in the Zaret lab, hypothesized that if human PDAC cells were reprogrammed back to pluripotent cells and then allowed to re-differentiate into pancreatic tissue, they might undergo the early stages of cancer. To do this, they created the PDAC pluripotent cells and indeed found that they recapitulated the early to intermediate stages of pancreatic cancer. They then isolated the cells at the early stage, cultured the cells in vitro, and identified the secreted and released proteins that might serve as early-stage biomarkers of disease progression.
There's one caveat, though, says Zaret. "Using the iPS method, we could only get a cancer cell line from one patient to reprogram, meaning this work is representative of one individual's cancer," noting that his close collaboration with John Hoffman, a surgeon from the Fox Chase Cancer Center (FCCC) was key in order to get fresh cancer cells for the reprogramming. They tried this method with cells from nine human tumors in total. However, as Zaret points out, there are many examples of where a single human cell line has served as a highly useful model for human disease.
"Our iPS-like cells exhibited pluripotency, like other stem cells, but when they differentiated after we injected them into the immunodeficient mice, they preferentially developed into early-stage pancreatic cancer cells," says Zaret. He explains that the approach is another example of using iPS cells from human patients to model disease, by capturing the genome of an affected individual. However, this is a first in solid tumor cancers, whereas many other labs have developed these types of cell lines for neurological and cardiovascular disorders.
The visual characteristics of these cancer cells -- as they progress from early- to late-stage cancer -- are typical of what is seen in cells analyzed from cancer patients in the clinic now. In the early stage, pancreatic ducts have lesions with cells of an abnormal shape, and express characteristic proteins as measured by stains. Over time, some of these aberrant cells may grow excessively, lose their ductal characteristics, and become invasive.
When the human PDAC iPS cells are grown as lesions in the mouse, they secrete or release proteins corresponding to protein networks expressed during the progression of human pancreatic cancer, namely molecules centered on a trio of key proteins: HNF4, integrin, and TGFbeta.
"We propose to look in the blood of potential pancreatic cancer patients or relatively early-stage patients for the biomarkers we found downstream of these molecular networks, to see if they are present in people," says Zaret.
The Making of a Model
This approach allows human cells to be studied directly, as opposed to examining characteristics of pancreatic cancer progression in an animal model and then having to assess whether the findings apply to humans. The cells harvested from the cancer patient were reprogrammed using the four Yamanaka factors carried in a lentivirus, which was adapted by the Zaret lab.
To see what the reprogramming did at a genetic level, the team compared the genomic structure of the early iPS pancreatic cancer cell line to original tumor cells from which the cell line was isolated. They found 23 chromosomal aberrations in the primary tumor cells as compared to 20 of the same chromosomal aberrations in the PDAC iPS line, demonstrating that the PDAC iPS line was derived from the original tumor cells.
By contrast, no chromosomal abberations were seen in cells taken from the margin of the tumor in a cancer-free part of the pancreas from the patient, as well as from an iPS line that the Zaret group made from the margin cells.
These sets of comparisons allowed the team to directly observe the changes in the pancreatic cancer cell line versus a normal cell line derived from the same human genetic background.
"We understand that the pancreatic cancer field has been dogged by searching for unique markers in the blood that detect disease early, and we hope that this live-cell progression approach will gives us a new way to see early molecular markers for pancreatic cancer," says Zaret.
"Since we can detect released protein markers of at least three different networks from the early-stage human lesions in our model, we think that looking for blood markers of the simultaneous activation the three pathways, instead of a single marker, could provide better leverage in detection. The new model could also be used to test drugs that block the intermediate stages of the disease. We would also like to know how we got lucky with this one cell line, so that the iPS technology can be adapted to model other human cancers."
The research was funded by the National Institute for General Medical Sciences through an NIH Merit award (R37GM36477)
Other co-authors are R. Katherine Alpaugh, Andrew D. Rhim, Maximilian Reichert, Ben Z. Stanger, Emma E. Furth, Antonia R. Sepulveda, Chao-Xing Yuan, Kyoung-Jae Won, Greg Donahue, and Jessica Sands, all from Penn, and Andrew A. Gumbs, from FCCC.


text:
good................but if that was ur first happy one...........how sad are th others?
the wrong way to heaven
Some people no the choices they make.
the lives they lead
the roads they take.
they go left
when thay should go right.
they turn away
from gods guiding light.
they don't reach out
and grab his helping hand.
they hesitate.
so, alone they stand
or at least they think.
he's watching over them
day and night
hopeing on the day they get it right.
till then, how he sees it
they'er walking the wrong way
to heaven.
my first happy one
good................but if that was ur first happy one...........how sad are th others?
I think you ment Know,Some people no the choices they make.
Dispite the correction, I thought this was a weel put together poem,
I do look forward how you are going to put your next work together!
Keep it up! !
my other ones r pritty depresing just look
that's awesome, i like this line!Originally Posted by just_an_awful_dream
definetly your best one yet (at least that i've seen)
You laugh at me because I'm different. I laugh at you because your all the same.
Thanks Hieislove for the siggy!
Wow did someone inspire this poem? I think it is really great!!!!For real...I suport your Poems all the way!!!!!!! good or bad


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WisdomTree Australia & New Zealand Debt Fund (AUNZ) Now Trading
WisdomTree (NASDAQ: WETF), an exchange-traded fund ("ETF") sponsor and asset manager, announced that previously declared changes to the WisdomTree Dreyfus New Zealand Dollar Fund became effective as of the market open today, October 25, 2011. The WisdomTree Australia & New Zealand Debt Fund (AUNZ) now offers broad-based exposure to local currency debt of Australia and New Zealand.
"Australia & New Zealand are uniquely situated geographically to potentially benefit from increased economic growth from Asia and currently offer attractive yields compared to other developed markets. We believe AUNZ offers a convenient way for investors to gain exposure to the local debt from these countries," said Bruce Lavine, WisdomTree President & COO.
Former Fund Name/Ticker |
New Fund Name/Ticker | Primary Change | ||||||
WisdomTree Dreyfus New Zealand Dollar Fund ( BNZ) | WisdomTree Australia & New Zealand Debt Fund ( AUNZ) | Restructured to provide exposure to Australia &New Zealand debt denominated in their respectivecurrencies. Extend duration to achieve intermediate-term Australia/New Zealand bond strategy. |
There are risks associated with investing, including possible loss of principal. Foreign investing involves special risks, such as risk of loss from currency fluctuation or political or economic uncertainty. Derivative investments can be volatile and these investments may be less liquid than other securities, and more sensitive to the effects of varied economic conditions. The Fund focuses its investments in Australia and New Zealand, thereby increasing the impact of events and developments in Australia and New Zealand that can adversely affect performance.
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If you are seeking a world-class educational experience within a vibrant, Christ-centered learning community, Cedarville is the place for you. Step up to the challenge of our arts, sciences, professional and graduate programs, and achieve more than you ever imagined. Be challenged and transformed by professors who are experts in their fields and invest their lives at Cedarville to mentor and guide students like you.
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Mar 28 2013Student Legislative Day Gives Pharmacy Students New InsightThree professional pharmacy students, Jordan Nicholls, Tara Perkins and Ashley Benjamin, were among the 50 students who had the... continue »
Mar 25 2013Research Symposium Promotes Campus ScholarshipThe fourth annual Research and Scholarship Symposium will be held on April 10 in the Dixon Ministry Center. The symposium seeks to... continue »
Mar 22 2013Students Partner with Charitable PharmacyIt's eight o'clock on a Saturday morning and most college students are still sound asleep. But not so for 45... continue »
Mar 5 2013Students Prepare for Jobs in Top IndustriesThe recently released U.S. News & World Report "100 Best Jobs" list features many careers that Cedarville is... continue »
Mar 1 2013Pharmacy Student to Compete in National Counseling CompetitionBethany Sibbitt, a graduate pharmacy student from Danbury, CT, will be traveling to Los Angeles to compete in the national level... continue »
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"Very pleased with the entire process...the stickers were the match to baby shower invitations. Will be ordering thank-you cards in same design. Appreciated having the Design Team look over my order prior to processing it. Thank you tinyprints!"
"This choice was perfect for me and my baby shower party favors. My order was deliveedr a day earlier than the suggested time, and the stickers were the perfect size and easy to remove from the backing and apply to the gift. I will definitely order other products! Thanks."
"I purchased these labels for packaging to use for my business. I loved the design so much I have since purchased the rest of the matching items to go along with my stickers. Beautiful work from Petite Alma!!"
"It was fun to put my both kids names on this sticker, but I still need to make one of this stickers with only one child name on it it, when they are not going together to B-days"
"I bought these to label my daughter's birthday favors. I have not used them yet, but they are a well made product and I bought the matching invitation. They feel like good quality stickers and look beautiful."


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POSTED: Sunday, February 2, 2014 - 8:59pm
UPDATED: Sunday, February 2, 2014 - 11:00pm
(KETK) - Tyler Tx — So maybe you overate and overdrank at your Super Bowl party, experts say that is okay and gave us some tips on how to make it through your work week.
First, hydrate! Local pharmacists say drink plenty of water, it will flush out any bad toxins. Second grab some heartburn relief. Third, keep the electrolytes nearby.
"The water, the Gatorade, things to kind of re-hydrate after drinking too much or eating too much," said Human Resources Manager at Target, Laura Hollingsworth.
And last, get some air, the fresh air can be extremely beneficial.


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FN's Top Recipes, Lightened Up: #5 Chicken Enchiladas
by Dana Angelo White in Healthy Recipes, Meal Makeovers, January 11, 2010
Every January, our big sister, FoodNetwork.com, tallies up their most-viewed recipes of the previous year. They've just unveiled their Top 50 Recipes of 2009 — all scrumptious dishes but not exactly waistline-friendly fare! If you're tempted to try out the best of the best, we don't want you to blow your diet. Every week, we are looking at one of the top five recipes and offering some simple tips for slimming them down without losing their flavor.
Coming in at #5 is Tyler Florence's Chicken Enchiladas. Good news: This dish is healthier than you might think.


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Photos & Pictures - The Manor
4 | AA Assessed Inn | Ratings explained |
A manor it may not be, but it is certainly elegant enough to be one. Today the hotel is a firm favourite with locals and travellers alike. You will be assured of a very warm welcome and great hospitality. Yeovil is the ideal spot from which to explore Hardy's Wessex. Nearby attractions include Glastonbury Abbey, Wookey Hole, Bath, Octagon Theatre, Cheddar Gorge and the Fleet Air Arm Museum of Yeovilton. The Manor has a large Car Park.
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Columnists Lorraine Morong Taylor Egg facts amaze Madbury crowd By LORRAINE MORONG The ongoing documentation of facilities that would be critical in case of an emergency was furthered when Catalina Celestano, division community relations manager for Eversource (formerly PSNH) visited with the selectmen on Feb. 20. Klondike Derby in Madbury keeps Scouts busy BY LORRAINE MORONG Despite a heavy overcast sky and temperature about 30 degrees and mountains of snow around the perimeter of the working field, 255 Boy Scouts and their leaders spent Feb. 7 at Tibbetts Field celebrating a Klondike Derby. Madbury budget hearing is Feb. 9 By LORRAINE MORONG The public hearing on the town's budget the Board of Selectmen is proposing for 2015 will be held at 7 p.m. in the Town Hall on Feb. 9 (tomorrow). The bottom line is $1,534,612, a 3.2 per cent increase over last year's budget. Madbury building, zoning changes on ballot By LORRAINE MORONG The zoning ordinances and building code changes proposed by the Planning Board will appear on the March 10 Town Meeting ballot. The public hearing held on Jan 21 relative to the proposed changes produced no opposition. Madbury's new library under discussion By Lorraine Morong Library Trustees Edna O'Sullivan and Noreen Gaetjens with Alternate Molly Wade and Library Director Susan Sinnott met with the selectmen on Jan. 16 to review the library's budget for 2015. Clarity sought on Madbury land use permits BY LORRAINE MORONG The Planning Board will hold public hearings on proposed changes to the Building Regulations and Zoning Ordinances which will appear on the Town Meeting Warrant (March 10). Madbury warrant petition now requires 25 BY LORRAINE MORONG Things change. In the 37 years since the editorial reprinted last week put on notice those who would have a petition placed on the Town Meeting Warrant that they need to get the petition in on time and have a certain number of signatures, the number has been changed. Madbury town meeting will be upon us soon By LORRAINE MORONG With a virtual cessation of official meetings of town boards during the holiday season, copy has been scarce. Consequently, this might be a good time to look ahead to the March Town Meeting, which will be on our agenda before we realize it. Madbury discusses future of volunteer fire department By LORRAINE MORONG A long-range look into the future of the Madbury Volunteer Fire Department's equipment took place when Fire Chief Tom Perley sat with the selectmen on Dec. 19 to review Perley's budget for 2015. Schreiber property now belongs to Madbury By LORRAINE MORONG Sixty-one acres of the Schreiber property off Cherry Lane now belongs to the town. On Dec. 12 the Board of Selectmen and Kurt Schreiber finalized the paperwork which has been in process for almost a year. Madbury pondering purchase of mowers By LORRAINE MORONG Including the area around Town Hall, the cemetery and the playing fields, Jim Davis reported to the selectmen on Dec. 5 that this amounts to 27.4 acres. Since these areas are mowed about every seven days in season, the total acreage mown in 2014 was 704 acres. Join other friends of Madbury Public Library By LORRAINE MORONG The trustees, friends and staff of the Madbury Public Library invite everyone to join them on Wednesday, Dec. 10, to celebrate the new logo for the library. This will be a Holiday Open House, from 4 to 5:30 p.m. Generous gift for Pumpkin Patch awaits approval By LORRAINE MORONG The famous Pumpkin Patch at Moharimet Elementary School is likely to be treated to 8 to 10 yards of compost this fall, in anticipation of next spring's sowing of seeds. Tom Corrow, visiting the selectmen on Nov. Tirabassi presented with Spiritual Care Award BY LORRAINE MORONG The members of the Union Congregational Church here have further reason to appreciate their pastor. On Oct. 21, the Rev. Maren C. Tirabassi was presented with Wentworth-Douglass Hospital's Spiritual Care Award. Madbury vote turnout was over 60% Having Senator Jeanne Shaheen as a resident sometimes creates a bit of excitement for the town. On Nov. 4 when Shaheen arrived (with a bevy of family members and others) to vote, the paparazzi preceded and followed her into and out of Town Hall. Bunker Hill water study grant draws a crowd By LORRAINE MORONG The selectmen's office was overflowing on the morning of Oct. 24. Donna Lane, the Community Development Block Grant consultant, remarked, "In my 30 years' experience, I've never seen such a turnout" for CDBG public hearings. Madbury historians learn Isles of Shoals is treasure trove By LORRAINE MORONG "Treasures" being found under the soil at the Isles of Shoals are rewriting the history of those nine small islands 10 miles off the New Hampshire coast and that of New England as well. Boy Scout Klondike Derby is Feb. 7 Town Clerk Kitty Cornwell reports that absentee ballots are available at the Town Office for those who cannot vote in person on Nov. 4 when the polls will be open from 7 a.m. to 7 p.m. at the Town Hall. New Moharimet cafeteria/gym honors Harrington By LORRAINE MORONG What a joyous celebration! It took place in the new cafeteria/gym at the Moharimet Elementary School on October 1. It was the dedication of this new space for which Principal Dennis J. Harrington has said he's been waiting for 25 years. Carleton Wentworth send-off at Kingman Farm By LORRAINE MORONG At the Kingman Farm on Sept. Boodey Rock site gets a cleaning Boodey Rock, across the road from Town Hall, has been given the attention it needed by the Durham – Great Bay Rotary. Early in the morning of Sept. 17, 10 Rotary members were busy digging up the poison ivy and other weeds which had invaded the enclosure which shields Boodey Rock. Madbury Historical group views ancient sugar maple By LORRAINE MORONG "If you can just hug a tree, its age is probably 100 years," according to Dr. David Olsen, who invited the Madbury Historical Society to visit a sugar maple tree stump which he reckons is at least 500 years old. Bellamy Reservoir survey reveals many violations Following a shoreline survey along the Bellamy Reservoir, two representatives from the City of Portsmouth's Public Works Department visited the selectmen on Sept. 7 to report the findings documented by two interns during two days spent in a boat on the reservoir. Brian F. Madbury wants to hear about school resource officer Town Clerk Kitty Cornwell is reminding everyone that the New Hampshire Primary will be held on Tuesday, Sept. 9. Voting at Town Hall will be from 7 a.m. to 7 p.m. Those who have not yet registered to vote may do so on the Primary Day. Madbury flag symbolizes diverse activities During the recent foraging through the Madbury church's records as the history was being uncovered for the church's 100th anniversary, a newspaper clipping relative to Madbury's town flag was discovered. The Christian Science Monitor on Oct. Union Congregational celebrates 100th anniversary The selectmen are hoping to hear from someone who could serve as an alternative attendant at the transfer station. This job involves about 20 hours per month, April thru November. Interested persons should call 742-5131. Meeting on Aug. Nute Road bridge still on agenda in Madbury According to CMA Engineering, Inc., the 2012 rebuild of the Nute Road culvert "has held up well to date." The selectmen were happy to have this report when they met on Aug. 4. Concert will celebrate Union Congregational Church's 100th By Lorraine Morong The August 9 concert celebrating the Madbury Union Congregational Church's 100th anniversary promises to be a once-in-a-lifetime event, according to Nancy Page who chairs the church's music committee. Town signs for purchase of Schreiber property The selectmen have signed a purchase and sales agreement for about 60 acres of the Schreiber property on Cherry Lane. Kurt Schreiber met with the selectmen on July 18 when the agreement was concluded. There will be public hearings on the matter still. Residents offer suggestions to Madbury selectmen The selectmen are looking for someone who could help for about 20 hours per month – April through November – at the Transfer Station. Interested parties should call 742-5131. Madbury suppers on summer schedule The ham and bean suppers sponsored by the Union Congregational Church here are on a different schedule for the summer. Such a supper will be offered on the third Saturday of each, July, August and September. These suppers will be served from 5 to 6:30 p.m. in the Madbury Town Hall. Ways to reduce mosquito threat advised in Madbury The Water Resources Board seeks to alert everyone that although Dragon Mosquito Control will be testing here for mosquito activity, individuals can help lower the potential level of the mosquito population. Madbury Day did not dissapoint us There was more to Madbury Day than what already was reported in last Sunday's paper. The Dessert Auction, a perennial event which benefits the FAST Squad, is always held at 5 p.m. when the hungry are anticipating their barbecued chicken dinner. Gravel pit owner keeps selectmen informed "How are you doing?" Selectman Bruce Hodsdon asked Paul Martel as Martel took a seat at the selectmen's table on June 6. Madbury Day schedule for June 14 Madbury Day is Saturday, June 14, and here is the schedule of activities! 9:15 - 11 a.m. - Music in the Morning Cafe - Music, coffee, desserts in Town Hall 9 - 2 p.m. - Book Sale and Open House at library 9:30 - 2 p.m. Hearing planned on Madbury development The Planning Board will hold a public hearing on June 4 for a new application submitted by the potential developer of the Abbott property on Huckins Road. Emergency memorandum questioned in Madbury The tax warrant has been signed, the bills are in the mail, and they are due July 2. The selectmen met with Dave Hutchinson on May 16. Hutchinson is the preparedness coordinator for Public Health Emergency in Strafford County. Fire Chief Tom Perley was also present for the discussion. Town Hall Road closed for Madbury Day parade By LORRAINE MORONG Since Town Hall Road will be closed to vehicles from 8 a.m. until after the parade on Madbury Day (June 14), a shuttle will pick up and drop off people at the Moharimet Elementary School parking lot and at Tibbetts Field. Fund-raising planned for Madbury library By LORRAINE MORONG The Friends of Madbury Library's Fund-Raising Committee told the Board of Selectmen on May 2 that an annual fund campaign will be launched this month with the goal of building a base of support for the library. Madbury Metals action plan received The selectmen dealt with a variety of issues when they met on April 25, among them the following: They acknowledged receipt of a copy of the N.H. New lights will shine at Madbury buildings The Town Hall, the Public Safety Complex and the library will be getting a makeover of their lighting systems soon. The selectmen, meeting with Kelly Freitas, the business manager for Lighting Retrofit Services, on April 18,voted to spend about $8,000 for the service. Huckins Road project's road discussed The selectmen have discussed with the men planning to develop seven lots on Huckins Road just how the upgrade of that Class VI road should be done. Developer Frank Catapano and engineer Joe Nichols were in the town office on April 4. Hodsdon will remain as Selectmen chair While it has been customary for the chairman of the Board of Selectmen to be that member whose term is waning, newly re-elected selectman Bruce Hodsdon will continue as chair since selectman Jay Moriarty, who is in the third year of his term, preferred this allocation of duties. Davis will tackle Madbury property upkeep The assistant fire chief will be taking on a wider role in town at the middle of the month. The selectmen have hired Jim Davis to do general upkeep of town properties and the mowing around them as well as the playing fields. Madbury planners hear about septic systems On March 19 the Planning Board heard from a natural resources scientist relative to septic system design. While Dr. Madbury meeting voters agree with selectmen Town Meeting on March 11 followed the pattern which has prevailed in recent years. There was little discussion of the articles which the selectmen recommended, with some back-and-forth relative to petitioned articles. Milton, Farmington consider sharing tax/clerk help The three selectmen, Tom Gray, Bob Bridges and James Beaulieu were in attendance. Also present TA, Elizabeth Dionne, Larry Brown, Lue Snyder, Farmington Town Clerk/Tax Collector, Kathy Seaver and the town's tax collector/town clerk, Michelle Beauchamp. Madbury absentee ballots available from clerk Representatives of PSNH visited with the selectmen on Feb. 28 to discuss having an energy audit done for the town's public buildings. |
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