text:
The Original Scent is what is on the market now as the plain bar soap scent. Back in the day when Irish Spring was fairly new, it smelled stronger and had a more masculine scent. They changed it to the current scent to make it more appealing to both genders. The Legendary Classic scent is supposed to be the earlier scent from the 1970s.
I can't describe the difference, but there is quite a bit of difference in the two. The Original Scent smells like the old Irish Spring soap bars that have been marketed for years. The Legendary Classic has a slightly different scent, but seems stronger and lasts longer.
One of the leprechauns doesnt have a 4 leaf clover cape? One makes u wrinkle even when your aroused? One smells like new spring and the other is swampy like old spice? Masage them in and let it marinate 3 hours, strange things will begin to grow and glow?
One smells like potayto and the other like potarto
My guess would be the labels and not much else.
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subset: commoncrawl


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What does 48004 stand for?
What does 48004 mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: 48004.
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48004 | Anchorville, MI |
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"48004." Abbreviations.com. STANDS4 LLC, 2015. Web. 27 Feb. 2015. <http://www.abbreviations.com/48004>.


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TRAGEDY still hangs over goalie's home town after bombing horror but Accies ace reveals that a love of the beautiful game is uniting the community.
WITH Christmas fast approaching blogger ANDREW SOUTHWICK tells Santa he's been a good boy this year and sends him his wishlist.
KRIS looks back over the recent international break and finds out how the Fir Parkers fared, from Windsor Park to Trinidad.
GOALS in either half from Jamie Ward and Kyle Lafferty gave Northern Ireland their third successive Group win over top seeds Greece.
NORTHERN Ireland fight back to win in Georgia after Niall McGinn and Kyle Lafferty scored second half goals.
THE 27-year-old helped Sicilian club Palermo return to Serie A last season and will now join Norwich as they launch their own promotion bid.
THE Northern Ireland frontman is now with runaway Serie B leaders Palermo and would like to return to Scottish football once he has tested himself in Italy's top flight.
THE former Rangers striker, now with Serie B Palermo in Italy, has failed to make any meaningful contribution and his national team boss is not happy.
PORTUGAL'S star man inspires a comeback in a game that saw Helder Postiga, Chris Brunt and Kyle Lafferty sent off.
TODAY'S Transfer Talk rounds up the latest news and wild speculation in the Scottish Premier League and beyond.
THE Rangers assistant saw the team criticised for their performances last season, but believes there will be big improvements next term.
THE Rangers boss also admitted he's involved in a fight with himself not to let Rangers' chaotic internal politics change him as a person.
A PANEL has ruled the Ibrox club must pay the expenses of five former stars who refused to transfer over when the old company went into liquidation last year.
THE 35-YEAR-OLD has taken charge of the Swiss side, who he joined as a player after leaving AC Milan at the end of last season.
STARS including Steven Davis, Allan McGregor, Kyle Lafferty, Steven Naismith and Steven Whittaker all left after Gers' financial collapse last year - but Davis says he'd like to return one day.
RANGERS legend Sandy Jardine has been vociferous in his criticism of the players who left Rangers without a penny in the summer given the sacrifices made elsewhere to help the club survive.
CHARLES GREEN has said Rangers will continue to pursue the money he believes they are owed from the transfers of Allan McGregor, Steven Whittaker, Steven Naismith, Kyle Lafferty, Sone Aluko and Jamie Ness.
THE RANGERS manager hopes that the widespread coverage of the club's collapse can help bring in players, while their chief executive remains determined to hunt former stars for breach of contract.
LAFFERTY and Naismith this week revealed their 'heartbreak' at the thought of never being able to return to Ibrox - but McCoist says they should have thought of that when they left.
THE former Ibrox striker said he made up his mind to leave five months before the end of last season, and is now suing for constructive dismissal.
THEY have had some excellent results of late, most recently in a friendly draw with Portugal, but Northern Ireland dropped points when it mattered tonight.
THE 27-year-old broke his international duck in winning his 11th cap on Tuesday, netting after 14 minutes only to see Luxembourg snatch a point at the death.
RANGERS have given a trial to German goalkeeper Rouven Sattelmaier . The 25-year-old was on the books of Bundesliga cracks Bayern Munich for two years without making a first team appearance. ( various )
THE Northern Ireland striker was one of several stars who refused to transfer his contract to the Ibrox newco as the old club lurched towards liquidation.
NORTHERN IRELAND needed a late goal from Martin Paterson to avoid defeat after leading 2-0 against Finland.
ANDREW LITTLE and Dean Shiels will be playing in the Third Division next season, but have been given a chance to prove they still belong on the international stage.
HERE'S your chance to comment on the big sporting issues of the day.
RANGERS owner Charles Green last night claimed the club will be handed an SFA licence today clearing the way for a return to action.
RANGERS owner Charles Green last night claimed the club will be handed an SFA licence today. But SFA chief executive Stewart Regan has hinted the whole issue could move closer to Friday's deadline.
RANGERS will sign Ian Black this week if the SFA hand the Ibrox club membership of the Third Division.
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I read the article was almost spilled coffee all over the keyboard and desk. This is a way to de-moralized the TSA. Man Takes Viagra, Wears Sweatpants for TSA Pat Down | The Washington Fancy Even though TSA officials allowed Kelvin to initially pass through security without the controversial pat down, the passenger on more than one occasion got back in line until he felt that he had been thoroughly inspected. Kelvin finally got the invasive pat down by 38-year-old officer Duncan Allbright after 80 minutes and four trips through security. Even after we let him pass through he kept walking out of the terminal and getting back in line, said Watershed. Finally, Duncan had to bite the bullet for everyone and do a thorough screening of him in a private [security] room. Allbright, a 14-year veteran of airport security, announced his retirement shortly after Kelvin boarded the plane. Im going home to take a shower and make love to my wife, said Allbright as he got into his car. This job isnt for me. Ive suddenly lost my passion for touching strangers.
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Laughed at the title of the thread before reading it, then laughed again!! Gotta wonder about just how weird people can get though!!
People get the government they deserve.
I have a buddy that just went to Hawaii and he said for the next TSA encounter he will wear a vibrating trojan ring.
DON'T BUY DELL!!!!! BEWARE!!! The toes you step on today may be connected to the ass you kiss tomorrow. PM Tango about his upcoming SHARTFOO courses.
That will teach-em.......
Hey, a cheap thrill is better than no thrill!
If your gonna get raped in the @ss by the airlines the.least the tsa can do is give ya a reach around.... Prolly bout time they offered that service anyway
"Gun control: The theory that a woman found dead in an alley, raped and strangled with her panty hose, is somehow morally superior to a woman explaining to police how her attacker got that fatal bullet wound." L. Neil Smith The problem with being stupid is you cannot simply decide to stop doing dumb things... "I crapped my pants to avoid the draft!!" -Ted Nugent
Oh, mygod! Too funny. I hope he closed his eyes and moaned through the whole pat down.
Thats hilarious, Everyone should start doing that. It should be a regular occurence to have to touch someones penis every time they pat someone down. Who cares what the TSA policies are if they don't have any employees?
His last name wasn't Boener by any chance........
For ever Vigilant..... One Shot One Kill.........
That wasn't Opaww was it??


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Warning: Telecom Prices May Be Too High
NEW YORK ( TheStreet) -- The U.S. Labor Department released a report on Sept. 25 saying that spending on phone services increased more than 4% in 2011 which was the fastest rate of growth since 2005. Customers want to stay connected and are activating cell phones like there's no tomorrow.
According to a recent Wall Street Journal report titled, "Cell Phones are Eating the Family Budget," more than half of all U.S. cell phone owners carry a "smart-phone" like the iPhone or a Droid. It's becoming more common for families to spend $200-a-month or more on cell phone services, and that trend looks like it may continue in the months ahead.
This has been part of the reason that the shares of the big telecom companies have been going to 52-week highs as revenues increase and so do dividend yields. The shares of the two big giants, Verizon (VZ - Get Report) and AT&T (T - Get Report) have been acting more like growth stocks instead of stodgy telecommunications companies.
By market cap the bigger of these two is AT&T. Weighing in with a $220 billion market cap, T hit its 52-week high of $38.58 on Sept. 21 and has barely corrected. With its close Wednesday of $38.08 it's been afforded a price-to-earnings ratio of over 50 and a forward P/E of almost 15.
Perhaps we shouldn't be surprised. According to The Journal article, the trend of multi-cell phone families is expanding so fast that big telecoms like AT&T and Verizon Wireless brought in $59 billion in revenue in 2011. That's a big jump over the $22 billion in revenue they earned in 2007. As you can see from the 5-year chart below, revenue-per-share growth has been one of the big drivers of share price growth. Selling services like mobile email and Web browsing is a very lucrative business. T data by YChartsCell phone services are one of the household spending categories that actually accelerated since the beginning of the Great Recession. According to the Labor Department, spending on "telephone services" has increased by 10% for households in America since 2007. Although last quarter's revenue growth was less than 1% year-over-year for AT&T, that still means their trailing-12-months revenue-per-share was a whopping $21.57. Their operating cash flow (trailing 12-months) was $35.35 billion dollars and their levered free cash flow was $9.69 billion.
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San Antonio, TX (Sports Network) - Tim Duncan turned in a vintage performance against an old rival, scoring 24 points and grabbing 11 rebounds as the Spurs downed the Suns, 102-91, on Sunday.
Tony Parker had 17 points and nine assists while DeJuan Blair scored 14 for the Spurs, who improved to 9-0 at home this season.
"Everybody made a conscious effort to play good defense," said Parker. "If you don't play good defense you're not going to be successful in this league."
Marcin Gortat paced the Suns, losers of four straight, with 24 points and 15 boards. Steve Nash added 20 points and 10 assists despite battling a bruised right quadriceps.
"Playing against Tim Duncan is a huge challenge," said Gortat. "He is one of the best post guys in the history of the NBA."
The Spurs have struggled to an 0-4 clip on the road this season, but continue to roll at home. On Sunday, they led by as many as 18 in the third before the fading Suns generated a spark.
The 39-year-old Grant Hill, who is himself battling a sore right quad, floated a layup over Duncan to cut the deficit to 10 midway through the quarter.
San Antonio maintained the edge, leading 78-68 after three, and Matt Bonner drained a corner three to make it 84-72 early in the fourth. The Suns countered with five straight, as rookie Markieff Morris hit a trey and Ronnie Price came up with a diving steal and found Shannon Brown for a layup. Price then followed a Blair reverse layup with a three, trimming the Suns' deficit to 86-80 with 8 1/2 minutes to play.
Duncan, though, kept Phoenix at bay, nailing a jumper for an 89-80 lead seconds later and sealing the victory with a 17-footer in the closing minutes.
Mike Callahan
David Jones
Leroy Richardson


text:
Events & Live Entertainment
Sand, Sun and even MORE fun!
This summer, join us for live entertainment including family movie nights, Hawiian Luaus and live music all right here at Springmaid Beach Resort!
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Grab a blanket, lawn chairs and the whole family and catch a flick on the Live Oaks Lawn while enjoying complimentary popcorn and $1 soft drinks.
Hawiian Luau
Each Wednesday on the Live Oaks Lawn, enjoy an authentic Hawiian Luau Buffet followed by captivating performances that culminate in a daring Polynesian Fire Dance.
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Soak up the sounds of summer on the Springmaid Pier with talented local musicians including Laidback Larry, Fin City, and Super Reggae Man just to name a few.
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Join us for daily Happy Hour drink and appetizer specials from 4-7 pm at BARnacles Bar & Grill located on the Springmaid Pier.
2014 Live Entertainment Schedule
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New for Summer 2014, Jack's Surf Lessons and Board Rentals! Located at the entry to the Springmaid Pier. Come surf with us daily with Surfboard Rentals and Lessons along with Paddle Board Rentals and Lessons. Join us for Surf Camp every Wednesday during the Summer from 8am-2pm. Surf ON!


text: Hi When trying to compile reiserfsprogs-3.6.19 on a LFS-svn-20061028 system, make fails with: In file included from ../include/reiserfs_lib.h:14, from includes.h:12, from do_balan.c:20: ../include/reiserfs_fs.h:41:27: error: asm/unaligned.h: No such file or directory Looks like asm/unaligned.h is not installed by the install_headers target of linux. I assume current BLFS-SVN is only expected to work with LFS-6.2, but I thought I inform you of troubles ahead. Rainer


text:
CARSON, Calif. - New Brazilian forward Samuel was brought to the LA Galaxy to finish the chances that the team often squandered in 2013 and on Wednesday against Club Tijuana, he did just that.
Samuel tallied the game-winner in the 11th minute off a sequence that began when Marcelo Sarvas launched a cross that bounced off Robbie Keane to the path of the Brazilian for the easy finish that sealed LA's 1-0 victory in the CONCACAF Champions League quarterfinal first leg. The goal wasn't the only high point for the Brazilian who provided a physical presence up top during his 70 minute shift.
"We played against a very difficult team so it was very important for me to score," said Samuel after the match. "I saw it come off Keane's knee and I was right there ready to score. ... Of course, I was expecting that ball to bounce to me. With a player like Robbie Keane, you have to expect everything so I was ready for the play."
Added Landon Donovan, "It was a good poacher's goal. He does that in training, he is always around the goal. It was good for him, an important goal, and he did very well tonight."
But one question remains: did Keane intend for that deflection to bounce in the path of the waiting Brazilian?
"Of course, you know me," asserted a chuckling Keane postgame.
CARSON, Calif. -- It was a moment that nearly lived in infamy for the LA Galaxy.
In the 61st minute with the Galaxy up 1-0 on Club Tijuana, goalkeeper Jaime Penedo made a palm stop of a Tijuana clearance that deflected off defender Omar Gonzalez and began to roll toward the goal line. But before the ball could roll over the goal line, Penedo tracked back enough to slap the ball away and preserve what was ultimately a 1-0 victory for LA.
"I was frozen. I caught the ball out of the corner of my eye because I didn't expect Jaime to drop it. I was already turning so I just stuck my leg out and I didn't know what was going on," Gonzalez recalled. "Jaime did an amazing job to dive and put it all out there."
Gonzalez wasn't the only player stunned by the play as Penedo admitted after the match that the entire sequence took place in "slow motion."
" I remember seeing Omar's face, it was pretty comical. I have to admit that when I stop the ball, I can't calculate how it'll bounce. It was just a quick reaction," said Penedo. "The ball was just touching the line."
The goal line clearance wasn't the only highlight for Penedo who enjoyed a strong second half that included two saves to keep the result heading into the all-important second leg.
"Jaime was great tonight," said Gonzalez. "He let them know that you're not getting in my net. I think that we're going to need an even better game from him next week, if that's even possible."
CARSON, Calif. -- LA Galaxy head coach Bruce Arena's thoughts following the team's 1-0 victory over Club Tijuana.
(On the 1-0 victory...)
ARENA: "It was a good win for our team against a good opponent, it was a difficult game but I am please we came out with a win. Obviously going to Tijuana next week is going to be a difficult match, but I am pleased with the position we are in. Tonight was a pretty even game, we had a couple chances at the end of the first half, and didn't get it, and then Tijuana pushed us real hard in the second half and it was a great result for our team to get a clean sheet tonight. We played well defensively."
(On the play of Galaxy goalkeeper Jaime Penedo who made two saves on the night...)
ARENA: "Jaime had a good night, a couple good saves, maybe a couple weren't because they put the flag up, but Jaime did well, he is getting back into form. Jaime is coming into the prime of his career, we think he is going to get better, I like to believe goalkeeper is a position that is strong for us now."
(On what to expect playing in Tijuana next week in the second leg...)
ARENA: "It will be difficult. Obviously, another goal would have benefited our team, but it's still nice going there with an advantage. Not giving up an away goal is important and we are well aware of the fact that Tuesday will be a difficult game. We will be ready.
(On the play of Galaxy forward Samuel who scored the lone goal of the night...)
ARENA: "He has done well, he really has. I could have kept him in longer tonight, but I felt that we needed to get some fresh legs in the midfield, and push Landon up top, but Samuel has done very well. He has adjusted well, and is very opportunistic around the goal, we've seen it in the preseason, and tonight a similar type of goal. He's got a good nose for the goal and he is just going to get better as he begins to understand our team and our league a little bit better."
CARSON, Calif. -- The LA Galaxy take on Club Tijuana in the CONCACAF Champions League quarterfinal first leg on Wednesday at StubHub Center.
Check out my look ahead to the match below.
*In the Galaxy's last pair of two-leg series, LA have struggled, but they're hoping to learn from the lessons of Monterrey and Real Salt Lake when they play Tijuana.
*Robbie Keane admits that Tijuana's inability showcases a "weakness" that the Galaxy will be looking to exploit on Wednesday.
*LAGalaxy.com's Larry Morgan provides his preview of the match.
*Lastly, check out my video round-up of all of the LAvTJ video content produced by LAGalaxy.com.
Juninho vs. Cristian Pellerano
A battle of attacking defensive midfielders, the two players will be looking to set the tempo for their respective teams early on.
Gyasi Zardes vs. Edgar Castillo
Speed vs. Speed. The hyperactive left back will look to push forward into the attack for Tijuana, but look for Zardes to attempt to take advantage of the space left by his agression to help the Galaxy.
Herculez Gomez vs. Omar Gonzalez
Whether Gomez will starts remains to be seen, but if he does, the Galaxy center back will have his hands full with the dangerous attacker. Expect the battle on the field to be as heated as their war of words.
PREDICTED LINEUP: Penedo; DeLaGarza, Gonzalez, Leonardo, Riley; Zardes, Juninho, Sarvas, Donovan; Keane, Samuel
Banter between MLS teams usually produces hilarious results, but this offering from an exchange between the LA Galaxy Twitter account and Sporting Kansas City's twitter may take the cake.
Check it out.
@SportingKC America's team? Nice try, guys but good luck tonight. pic.twitter.com/6HAZMEJC4A
— LA Galaxy (@LAGalaxy) March 12, 2014
In the final installment of our LA Galaxy vs. Club Tijuana video series, I take a look at the three most interesting pieces of content that were produced on LAGalaxy.com in the lead up to Wednesday's match.
Check it out below.
CARSON, Calif. -- LA Galaxy head coach Bruce Arena and forward Landon Donovan spoke to reporters in a press conference at StubHub Center on Tuesday ahead of their CONCACAF Champions League quarterfinal against Club Tijuana.
Check it out below.
CARSON, Calif. – The LA Galaxy came into the 2014 campaign eager to learn from the failures of a year ago, and they'll get their first opportunity to right the wrongs of 2013 when they kick off their CONCACAF Champions League quarterfinal series against Club Tijuana on Wednesday.
The two biggest letdowns of 2013 saw the LA Galaxy falter in two-leg series falling to C.F. Monterrey in the CCL Semifinals and Real Salt Lake in the Western Conference Semifinals. Despite being played months apart, both series featured similar problems for the Galaxy as the team was unable to convert a number of scoring opportunities in the home leg before crashing out away from StubHub Center.
To correct these issues, the Galaxy invested heavily in experienced players during the offseason in hopes of turning the club's fortunes around. A strategy that the team is hoping will pay off come Wednesday evening against Club Tijuana.
"We have to learn our lessons from previous games," said defender Todd Dunivant, who is expecting to be available for Wednesday's match after dealing with a nagging injury. "When you talk about previous games, you look at the Monterrey home leg, where we were dominating that game for 80 minutes and feeling confident that we could get another goal or another two goals but we lost our shape and when you do that against good teams it's going to hurt you. We have to be smart.
"This year, this team has brought in more experienced players with guys like Rob Friend, Stefan Ishizaki that have been in big games and won championships in other countries," Dunivant added. "There's definitely a different mood around our clubhouse."
And the first lesson that the Galaxy must learn? Finish their chances at home.
"In both of those games, we played very well, but we didn't finish our chances and it gets magnified in these series," said Landon Donovan. "In a series like this, every goal is important. In both of those games, we played well at home, but we couldn't finish our chances. We just have to be better in front of goal. It's as simple as that."
The LA Galaxy are looking ahead to their CONCACAF Champions League quarterfinal series against Club Tijuana and in the lead up to Tuesday's match, CONCACAF.com spoke to several members of the club on the upcoming tournament.
The video includes a few interesting and dramatic shots of StubHub Center as well as informative interviews so check it out below.


text:
Battlefield Ethics: Links
A selection of links to religious and other ethical stances on war, military practices, and pacifism.
GeneralWar in World Scripture
A collection of quotes from Islam, Christianity, Sikhism, Hinduism, Judaism, and other faiths about war, religious duty to fight, fight against evil, war within one's self, and other topics.
Joint Services Conference on Professional Ethics
An organization of military professionals, academics and others formed to discuss ethical issues relevant to the military.
A History of Conscientious Objection and Religion During the Vietnam War
Includes a history of conscientious objection, an analysis of conscientious objection during the Vietnam War, and religious reactions to conscientious objection.
Just War Theory
An explanation of the theory dealing with the ethical justification of war, types of warfare, and rules of combat.
In Defense of Dharma


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About TIGed
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Global Gallery > TIG Set > Perspectives: Youth Insights on Global Issues > Let them Fly!
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Looking for movie tickets? Enter your location to see which movie theaters are playing Sinatra near you.
Developed by Tina Sinatra and approved by Frank himself, Sinatra is a made-for-television mini-series following the life and times of Frank Sinatra, one of the most popular and acclaimed singers of the 20th century. Opening with his childhood in Hoboken, New Jersey, the film follows Sinatra's (Philip Casnoff) rise to the top in the '40s, through the dark days of the early '50s and his triumphant re-emergence in the mid-'50s, to his status as pop culture icon in the '60s, '70s and '80s. In between, the film hits all of the main events, including his three marriages, his connections with the Mafia and his notorious friendship with the Rat Pack. Even with the presence of Tina Sinatra as executive producer, Sinatra doesn't gloss over the more unsavory portions of Frank's life, which makes it all the more impressive. With the exception of a couple of early songs, all the music in the movie is taken from the original Sinatra recordings. ~ Stephen Thomas Erlewine, Rovi


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1. Gentoo Linux Security Advisory
Version Information
Related bugreports: #174375
Multiple vulnerabilities have been discovered in ClamAV allowing for the remote execution of arbitrary code.
2. Impact Information
ClamAV is a GPL virus scanner.
iDefense Labs have reported a stack-based buffer overflow in the cab_unstore() function when processing negative values in .cab files. Multiple file descriptor leaks have also been reported in chmunpack.c, pdf.c and dblock.c when processing .chm files.
A remote attacker could send a specially crafted CHM file to the scanner, possibly resulting in the remote execution of arbitrary code with the privileges of the user running ClamAV.
3. Resolution Information
There is no known workaround at this time.
All ClamAV users should upgrade to the latest version:
Code Listing 3.1: Resolution
# emerge --sync # emerge --ask --oneshot --verbose ">=app-antivirus/clamav-0.90.2"
4. References
Page updated April 24, 2007
Summary: This is a Gentoo Linux Security Advisory
Security Team Contact Address
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This President has a giant ego regardless of the fact he can't "cut the mustard". He's going to work hard at achieving his reelection, but he's finished as president. Hopefully their won't be any national tragedy, engineered or otherwise that would facilitate his new title as "Dictator of LIfe"…no different than a Caesar…ouch!
Rest assured his party will waste hundreds of millions of dollars to get him reelected, but I know it is not to be so. He's simply a holding president between "rethug regimes. It's time for our shadowy controllers to turn the sod over and give us a fresh crop of "rethuglican games" at our collective expense. / : |
Carl Nemo **==


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Jazz pianist, bandleader and composer Horace Silver died Wednesday at age 85. Fresh Air critic Kevin Whitehead says that Silver had been off the scene awhile, but his influence is as strong as ever. Hear an appreciation.
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text: Founded in 1812 at Chambery, France, by a colony of sisters frorn the mother-house at Lyons. The Rule, based on that of Saint Augustine, was approved in 1874. The congregation, formerly diocesan, then became subject to a superior-general. It has been established in the United States since 1885. The congregation has 147 houses, including parochial and high schools, hospitals, a leper asylum, homes for the aged, workrooms for girls, and orphanages, in France, Belgium, Switzerland, Norway, Sweden, Denmark, Iceland, Italy, Brazil, and the United States (in the Archdiocese of Baltimore, and the dioceses of Hartford and Springfield). The general mother-house is still at Chambery, the provincial house for the United States at Hartford, Connecticut.New Catholic Dictionary


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IRASBURG The Vermont State Police say a couple from Irasburg is facing heron and variety of other charges after their home was searched by investigators.
Police say the home of Robert Cote and Sonya Perkins, both 24, was searched Thursday after an investigation by the Vermont Drug Task Force that lasted for several weeks.
Cote was charged with of sale and trafficking of heroin, possession of depressant, stimulant or narcotic drug, possession of marijuana as well as child endangerment and using a weapon in the commission of a felony. Perkins was charged with trafficking heroin, child endangerment, possession of marijuana, and possession of depressant, stimulant, or narcotic drug.
Police say the couple has two children.
Cote is being held on $100,000 bail. Perkins was released.MORE IN This Just InSummer Street redevelopment project shrinks some Full StoryCV waste district eyes see-through garbage bag requirement Full StoryA major new study of smoking and death has banged more nails into the coffin of cigarette... Full Story -
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Caritas prides itself on providing safe, well-maintained, stable housing. Each house is supervised by a live-in Resident Manager responsible for the well-being of the residents and the upkeep of the property. Caritas partners with several direct care agencies including Vinfen, Heading Home, AIDS Action Committee, Pine Street Inn, the Veterans Northeast Outreach Center, and the New England Center for Homeless Veterans. The Caritas model creates sustainable properties that lessen the need for homeless shelters. By running our properties on a not-for-profit basis, renting at below market rents, and partnering with service agencies, we make it possible for our residents to have a permanent home — and to maintain dignity and stability in their lives.
At Caritas, we believe that every person deserves a safe, clean place to call home.


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Details The choice of renowned guitarmakers for their finest instruments.Lightweight, exotic snakewood is ideal for a non-traditional, modern look. Waverly tuners feature old style tapered 1/4"-diameter string posts and the press-fit brass hex bushings fit 11/32"-diameter pegholes. Set of 6 gold tuners, 3 left/3 right, screws included. With Waverly tuners, your guitar plays in tune and stays in tune. Waverly's patented design combines stainless steel with bronze to create smooth, non-slip tuning. The perfect replacement tuners for valued instruments, Waverly machines are handmade to fit precisely without drilling on older Martin and Gibson guitars. Manufacturers such as C.F. Martin, Gibson, Collings, Santa Cruz, Huss & Dalton, Sams, and Bourgeois choose Waverlys for their finest instruments. Whether you're fitting a solid-peghead or slotted-peghead guitar, there are Waverly models to fit. Conversion peghead bushings are available for installing Waverly tuning machines in larger diameter 3/8" diameter (Grover, Gotoh, Schaller, etc.) pegholes. Direct replacement design: No additional mounting holes to drill when replacing similar vintage machines on older Martin & Gibson guitars. More efficient operation & more precise tuning: 16:1 gear ratio. Patented worm tension bushing eliminates looseness. Long life with less wear: Stainless steel worm gears have twin bushings. String post gears are machined from bronze alloy; more durable than brass. Authentic knobs and string posts: Knobs are genuine snakewood. Old style tapered string posts are gold-plated brass. Peghead Bushing ReamerFor Waverly guitar tuning machinesGet the right fit! This slow-speed bushing reamer has a 1/4" pilot and 11/32" shank. Two 1" flutes cut a .340"-diameter counterbore for Waverly press-fit peghead bushings. Waverly Tuning Machines: The Choice of Renowned Guitarmakers Altman Bear Creek Beard Bedell Guitars Borges Bourgeois Breedlove Buscarino Collings Franks Froggy Bottom Galloup Gibson Goodall Hooper Huss & Dalton Kallenbach Knaggs Ko'olau Kopp Larrivée Lewis Lucas Maingard Martin Merrill National Paul Reed Smith Proulx Rockbridge RoZaWood Sams Santa Cruz Schaefer Schoenberg Sexauer Skipper Steinegger Tippin Webber "They hold their tune and look superb…of course I recommend Waverly." —Dick Boak, Martin Guitars "Our favorite tuners." —Collings Guitars "The best tuning keys on the market." —Tony Rice "Anyone using a lesser tuner is making their life more difficult." —Jorma Kaukonen "Fast and precise retuning on stage or in the studio is no longer a problem, and finally the tuning machines look as good as the instrument. What did we do before Waverlys?" —Steve James, Austin TX "Fast tuning on stage or in the recording studio…smooth action and good weight." —Herb Pedersen "They work as beautifully as they look. The very best!" —Jim Merrill, Merrill Guitars "Simply the best tuners available for acoustic guitars—I wouldn't use anything else." —Dakota Dave Hull "Like putting a Rolex on your guitar!" —M.J. Franks Guitars
HD28 Waverly Snakewood By marknelson from Dayton, Nevada (Customer's Reviews) Saturday, April 05, 2014 OK well lets just say THANK YOU STEWMAC! The tuners were great and made all the dif. in the world, they look great and are smooth in function, they make any Martin into a strateveris. The tools are a must have the Drill jig bushing press and the Drill bits with the stops, DONT EVEN try this with out them, THANKS STEW MAC!
Brilliant! By VTGUY from VT (Customer's Reviews) Friday, February 28, 2014 High performance and spectator looks...what more could anyone ask for?
Perfect.. By Neel from Aiken, SC (Customer's Reviews) Wednesday, December 25, 2013 0f course Waverlys are the best.. I ordered the Snakewood Knobs for the look that I wanted.. Knobs are strictly 'personal preference'!!
smooth and classy By Sterny from VA (Customer's Reviews) Thursday, October 31, 2013 Fit perfectly on my 1946 Martin 00-18. Smooth tuning, classy gold, snakewood reminds me of brazilian rosewood. Expensive but worth it.
The perfect finising touch By gutardon from Chicago (Customer's Reviews) Wednesday, April 03, 2013 I bought a Collings Baby 01 with the standard tuners and regreted not getting the Sankewood tuner upgrade. So I ordered a set and it is definately worth the money. The add the finising touch to an already perfect guitar.
The finest tuners on the market By Beau Hannam Guitars from Grand Junction, CO (Customer's Reviews) Monday, April 09, 2012 Waverly tuners are the final element needed in order for your hand crafted guitar to look truly great. It is that simple. Beau Hannam Guitars
Not for everyone By Bill Scanlon from Keller, TX (Customer's Reviews) Wednesday, July 20, 2011 I agree that these tuners are top notch, but to the everyday player they are not worth the extra money. I installed these for a customer who is a professional player. He did not see a significant improvement over the original tuners that came on his Martin. Certainly not triple the moneys worth.
The ONLY tuners I use! By Brock Poling - Poling Guitars from Columbus, OH (Customer's Reviews) Wednesday, December 01, 2010 Waverly's are the only tuners I use on my custom guitars. For me, nothing beats them.
EXCELLENT UPGRADE FOR THAT SPECIAL GUITAR By hkmls5 from New Jersey (Customer's Reviews) Friday, October 22, 2010 The Waverly Guitar Machines make a beautiful upgrade for an existing tuner, or a really classy statement for a new guitar. These took my Martin, a step further in class. The snakewood is a great match for the guitar. These also hold tune so much better than the less expensive tuners. Sometimes it is true that you get what you pay for. Stew-Mac stands behind these tuners, and they offer great support in choice and installation. This is a winning selection.


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Paco Eugene | 6a | ||
2 pitches. A long and classic expedition. Start at the base of the face. The lower two pitches need a small rack. If you wish to do the upper section of the route only, it can be reached via pitch 1 of Nirvana. 1) 5, 18m. Climb the wall past some bolts. Wires needed. 2) 4, 23m. Continue up the easiest line to a large belay ledge. Wires needed. 3) 5, 15m. Climb up leftward to the start a crack system. 4) 6a, 24m. The crack to the top. © ROCKFAX Wander up from the base of the gorge for 2 pitches (wires needed), or gain the stance at the start of the main groove from Nirvana (better, and more usual). From the stance, step left and climb up the twisting grooves, normally in 2 pitches. Submit a new photo of this climb. | |||


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Tesla's Short Sellers Refuse to Pull Over
NEW YORK ( TheStreet) -- Tesla (TSLA) is many things to many people. For short sellers, it represents a position they don't want to abandon, as shown in the last reporting period when short interest edged higher.
While short interest declined from a March 15 peak of over 40% to "only" 32% of the float on June 14, it rose from two weeks earlier. Short interest deflating in the aftermath of a tripling in share price is unsurprising. Also, what shouldn't surprise investors is that short sellers have slowed down only briefly.
With only 19.9 million shares short, it's the second lowest reported number during the last 12 months. When taken at face value and out of context, it's easy to conclude that the bulls have trampled the bears. When viewed inside the context of a stock driving from less than $40 to $100, a short interest level over 30% is a caution flag waving widely.
Between the previous two-week reporting period and the last report on June 14, shares in Tesla remained stable, changing a total of about $2, although with considerable volatility in between. It was during the same period that short interest climbed for the first time since the middle of March.
Why do investors care about short seller activity? Because investors should expect short interest to collapse under the weight of margin calls and stop losses. Instead, short sellers are refueling for another lap around the track. Profit expectations are why you expose your portfolio to unlimited risk to obtain a limited payoff; shorts continue to believe the odds favor a significant decline in share price. Shorts underestimated Tesla's billionaire CEO Elon Musk and have paid dearly. They think the market will allow Musk only so much time before moving on. If Musk, however, captivates the hearts and minds of investors like Amazon (AMZN) CEO Jeff Bezos has, Tesla may get all the time in the world. We're talking about cars, and Tesla is producing a top-rated muscle car sporting a retail price of less than $100,000.Check Out Our Best Services for Investors
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Alexander McQueen Resort 2013
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Alexander McQueen Resort 2013
The '70s style of David Bowie and the paintings of Gustav Klimt inspired the form-fitting, metallic-patterned Alexander McQueen Resort 2013 collection. After a few seasons of showing little other than intensely detailed dresses and gowns, Sarah Burton said she "wanted to bring everything back to the body." She accomplished that by pairing generously lapeled, torso-hugging blazers with lean, boot-cut trousers and by cinching those menswear-inspired looks with wide belts. Many of the dresses got the same belted treatment but featured fabrics and treatments — like an art deco metallic jacquard or intricate gold embroidery — that helped serve as a feminine response to the collection's more masculine pieces.
Read More Alexander McQueen Resort 2013A Little Turn On The CatwalkResort 2013Sarah BurtonEditor's PickAlexander McQueen
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EU agrees in principle to ban Iranian oil imports
PUBLISHED: 05 Jan 2012 06:27:17 | UPDATED: 06 Jan 2012 02:59:19PRINT EDITION: 05 Jan 2012European governments have agreed in principle to ban imports of Iranian oil, EU diplomats have said, dealing a potentially heavy blow to Tehran.
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Glioblastoma: morphologic and molecular genetic diversity.
* Context.--Glioblastoma (GBM), the most common primary intracranial malignancy, is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy. Only 3 distinct morphologic variants of GBM are currently recognized by the current World Health Organization classification scheme, including GBM, giant cell GBM, and gliosarcoma. Additional variants, some of which have significant morphologic overlap with tumors that have more favorable prognosis and treatment response rates, particularly anaplastic oligodendroglioma, have been described since its publication in 2000 and may be included in the next classification.Objective.--To summarize the morphologic and molecular genetic diversity of both well-established and novel GBM variants and outline our approach to these heterogeneous neoplasms and their distinction from other diffuse, high-grade gliomas.
Data Sources.--Published literature and our own experience in an active academic diagnostic surgical neuropathology practice were reviewed.
Conclusions.--Precise subclassification of GBM is required for accurate prognostication and appropriate treatment planning.
(Arch Pathol Lab Med. 2007;131:397-406)
Diffuse, infiltrative gliomas are the most common primary intracranial neoplasms, accounting for 40% of all primary and 78% of all malignant central nervous system tumors. (1) More than 80% of these tumors are considered high-grade (grades III and IV) when diagnosed according to the current World Health Organization (WHO) classification, a system based on morphologic evidence of differentiation along astrocytic, oligodendroglial, or mixed lineages. Classification and grading criteria for astrocytic neoplasms are well established, having been refined periodically during the last 80 years from the classification schemes of Bailey and Cushing, (2) Kernohan, (3) Ringertz, (4) Nelson, (5) St. Anne-Mayo, (6,7) and WHO. (8,9)
The WHO 2000 criteria are currently the most widely accepted scheme and are based largely on the St. Anne-Mayo classification. For example, it uses mitotic activity to distinguish anaplastic astrocytoma (AA), WHO grade III, from its low-grade counterpart, diffuse astrocytoma, WHO grade II. Median overall survival (OS) for patients with AA is typically 3 to 5 years. (10) Microvascular proliferation (MVP), loosely defined to include endothelial hypertrophy, endothelial hyperplasia, and glomeruloid vessels, and/or necrosis are distinguishing features of WHO grade IV astrocytoma, the latter being synonymous with the commonly used term glioblastoma multiforme or simply glioblastoma (GBM) in the current WHO scheme. (10) Despite advances in microsurgical techniques, radiation, and chemotherapy, GBM is still associated with a median OS of approximately 1 year. (6) In its most mature and prognostically significant manifestation, MVP is recognized as multilayered tufts of hyperplastic and mitotically active endothelial cells, accompanied by smooth muscle cells and pericytes. The presence of MVP in GBM has been correlated with hypoxia-induced neoangiogenic and infiltrative phenotypes, the former of which is characterized by expression of cytokines such as vascular endothelial growth factor. (11,12) Microvascular proliferation is both temporally and spatially linked to the presence of necrosis, particularly pseudopalisading necrosis. (11,12) These morphologic criteria are highly reproducible and serve as useful prognostic factors for OS. (13-15)
Glioblastoma may arise through 2 distinct pathways of neoplastic progression. Tumors that progress from lower-grade (II or III) astrocytic tumors, termed secondary or type 1 GBMs, typically display both well-differentiated and poorly differentiated foci. Secondary GBMs develop in younger patients (fifth to sixth decade), with time to progression from lower-grade lesions ranging from months to decades. In contrast, primary, type 2 GBMs develop in older individuals (sixth to seventh decade), have short clinical histories (less than 3 months), and arise de novo without any evidence of a lower-grade precursor. Primary and secondary GBMs also harbor distinct molecular genetic abnormalities: Primary GBMs are characterized by relatively high frequencies of EGFR amplification, PTEN deletion, and CDKN2A (p16) loss, whereas secondary GBMs often contain TP53 mutations, especially those involving codons 248 and 273 or G:C[right arrow]A:T mutations at CpG sites. (16) The clinicopathologic and molecular genetic features of primary and secondary GBM have been recently reviewed in detail by Ohgaki and colleagues. (16)
The term GBM was coined by Mallory in 1914 (17) and solidified in the lexicon of surgical neuropathology by Bailey and Cushing in 1926. (2) As the original designation multiforme implies, GBMs comprise a morphologically highly heterogeneous neoplasm. In other words, the cellular composition, even within a single tumor, can vary widely and mixed histologic features are typical. (18) Three GBM variants are recognized as distinct clinicopathologic entities in the current WHO classification: conventional GBM, giant cell GBM (GC-GBM), and gliosarcoma (GS). In addition, other variants of GBM with distinct clinicopathologic and genetic features have been described (Table 1). In the present review, we discuss the cytologic heterogeneity that may be encountered in the variants of GBM and outline our approach to their subclassification.
Conventional GBM
Even within the conventional GBM category, the cellular composition is heterogeneous and may include fibrillary, gemistocytic, and/or occasional giant cells (GCs). Neoplastic fibrillary astrocytes contain enlarged, elongated to irregularly shaped, hyperchromatic nuclei, scant cytoplasm, and variable glial fibrillary acidic protein (GFAP)--immunoreactive processes that form a loose, fibrillary matrix (Figure 1). Such tumors may also harbor mucin-rich microcystic spaces. Because of cross sectioning of spindled or cylindrical nuclei, neoplastic fibrillary astrocytes may also appear to have occasional rounded nuclear profiles, raising the differential diagnosis of high-grade oligodendroglial (HGO) neoplasms (WHO grade III anaplastic oligodendroglioma [AO, O3] and WHO grade III anaplastic mixed oligoastrocytoma [AOA, MOA3]). Nevertheless, a significant fraction of cells should have classic cytology (eg, round uniform cells with sharp nuclear membranes and bland chromatin) before one invokes an oligodendroglial component in the diagnosis.
Gemistocytes were first described by Franz Nissl as glia (gemaestete glia) with voluminous cytoplasm. (19) Gemistocytic astrocytes contain plump, glassy, eosinophilic GFAP-immunoreactive cytoplasm; eccentric, irregularly shaped, hyperchromatic nuclei; and short cytoplasmic processes (Figure 2, A and B). Once thought to represent a reactive component, these cells have been found to harbor TP53 mutations (20) and cytogenetic abnormalities (chromosome 7p gains and 10q losses) (21); therefore, they are now thought to represent a true neoplastic component. Perivascular lymphocytic infiltrates are also a common but nonspecific finding in these tumors (Figure 2, A).
Although gemistocytes may be found in all grades of astrocytoma (II, III, and IV), gemistocytic astrocytoma is currently recognized as a distinct variant only of diffuse astrocytoma (WHO grade II). In this context, the WHO defines a gemistocytic astrocytoma as an astrocytoma composed of more than 20% gemistocytes. (10,22) The prognostic impact of gemistocytic cytology in astrocytomas has been an active area of investigation during the last 40 years. (22-26) Various reports have quantified the percentage of gemistocytes present in a tumor, a feature termed the gemistocytic index, and sought to correlate its significance with patient outcomes. Gemistocytic astrocytoma (WHO grade II) with greater than 5% gemistocytes have been reported to progress more rapidly to GBM. (27) Some groups have suggested that these tumors behave more aggressively than their non-gemistocytic grade II counterparts and thus deserve a grade III designation. However, the prognostic significance of the gemistocytic index in grade II and III astrocytomas still remains unclear and no studies have examined the independent significance of this factor in tumors with the grade IV features of MVP and/or necrosis. This work and its historical underpinnings has been summarized in a recent review by Tihan and colleagues. (26)
Granular cell astrocytomas are rare astrocytic neoplasms composed of sheets of large, deceptively bland cells with abundant granular, periodic acid-Schiff-positive cytoplasm (Figure 3). (10,28-31) Most granular cell astrocytomas are GFAP positive and may nonspecifically display cytoplasmic epithelial membrane antigen but no cytokeratin immunoreactivity. (28,29) Similar to astrocytomas with nongranular cytology, these tumors may also harbor TP53 mutations, high-frequency loss of heterozygosity at 9p, 10q, and 17p, and less frequent loss of heterozygosity at 1p and 19q. (30) Ultrastructural studies have shown that the cytoplasmic granularity correlates with increased lysosomes, evident as either dense or multivesicular bodies. (28,29) Brat and colleagues (28) reported the largest series of such tumors to date (22 cases, including 4 grade II, 7 grade III, and 11 grade IV tumors) and found that these tumors were more aggressive than non-granular cell astrocytomas of the same grade. Given their average survival of 7.6 months, it may indeed be appropriate to consider them variants of GBM.
Giant Cell GBM
Giant cell GBM constitutes approximately 5% of GBMs and is recognized as a distinct clinicopathologic entity in the WHO 2000 classification. (10) Although occasional neoplastic GCs may be found in conventional GBM, these cells are a dominant cytologic component in GC-GBM. As the name implies, the tumor cells are markedly enlarged and bizarre, often appearing multinucleated (Figure 4, A). Giant cell GBMs are typically well-circumscribed masses that occur in younger patients (fifth decade). Their molecular genetic features include relatively high frequencies of TP53 mutations (75%-90%) and PTEN deletion (5%-30%), whereas EGFR amplification and CDKN2A deletion are rare in comparison to conventional GBMs; therefore, GC-GBMs contain clinical and molecular genetic features of both primary and secondary GBMs and as such occupy an intermediate position between these two. (10,32,33)
Several reports have demonstrated a slightly better prognosis for GC-GBM than for conventional GBM. (10,34) Nevertheless, the prognosis remains poor overall. As shown in Table 2, this has similarly been our experience at Washington University School of Medicine. Among 453 supratentorial GBMs newly diagnosed between 1990 and 2005, only 7 (1.5%) were GC-GBMs. These patients were approximately 10 years younger than those with non-GCGBMs. Median OS was 11.4 months for GC-GBM, compared with 9.3 months for non-GC-GBM. However, this difference was not statistically significant (log-rank P = .48) after adjusting for patient age and surgery type (re-section vs stereotactic needle biopsy).
A potential molecular mechanism for GC formation has recently been described. (35,36) The process of endoreduplication results in multiple cycles of DNA replication associated with a failure of cell division, thus causing markedly enlarged polyploid nuclei with extensive chromosomal gains (Figure 4, B). Using antibodies to specific phosphorylation sites on vimentin and GFAP catalyzed by various kinases, including cdc2, CF, Rho, protein kinase C, and aurora-B, investigators have shown that the molecular alteration that causes failure of cytoplasmic cleavage in cultured multinucleated GCs is loss of aurora-B kinase function. (35,36) Importantly, loss of aurora-B kinase-mediated phosphorylation was confirmed in human GC-GBM samples. (35) However, aurora-B kinase has been shown to be overexpressed in astrocytomas in general, with both mRNA and protein levels correlating with WHO grade. (37) Therefore, the molecular basis for aurora-B kinase dysfunction (mutation, gene deletion, methylation) in GCs and its overexpression in non-GC-GBM remains to be established.
Gliosarcoma and "Adenoid" GBM
Gliosarcoma constitutes approximately 2% of GBMs and is likewise recognized as a distinct clinicopathologic entity in the WHO 2000 classification. (10) These tumors are characterized by their well-circumscribed, biphasic growth pattern with clearly identifiable glial and metaplastic mesenchymal components (Figure 5, A and B). The glial component of GS may show any of the aforementioned cytologic features and is typically immunoreactive for GFAP (Figure 5, D). The mesenchymal componentmay also show a wide variety of morphologic appearances, with evidence of differentiation along fibroblastic, cartilaginous (Figure 5, E and F), osseous, smooth and striated muscle, and adipose lines. (10) These areas are generally characterized by dense extracellular matrix deposition, the latter evident on reticulin-stained sections (Figure 5, C, upper) and contrasting with the typically reticulin-poor glial component (Figure 5, C, lower). In addition to sarcomatous differentiation, epithelial metaplasia may also occur in either GS or conventional GBM, including areas of keratinizing squamous or glandular differentiation. Such cases often invoke a differential diagnosis of metastatic carcinoma. The latter is illustrated in Figure 6, A, an "adenoid glioma" that was immunoreactive for both GFAP (Figure 6, B) and low-molecular-weight cytokeratins (CK7; Figure 6, C). Overall, these tumors are exceedingly rare and are thus far not recognized as a distinct clinicopathologic entity by the WHO.
Several reports have demonstrated a slightly better prognosis for GS than for conventional GBM. (10,38) However, the differences in OS have been statistically insignificant in most series. This too has been our experience at Washington University School of Medicine (Table 2). Among the 453 newly diagnosed, adult supratentorial GBMs, only 10 (2.2%) were GSs. These patients were of similar age to those with no sarcomatous component. Median OS was 7.6 months for GS, compared with 9.3 months for conventional GBM. This difference was not statistically significant (log-rank P = .33) after adjusting for patient age and surgery type.
Metaplasia in non-central nervous system epithelial tumors is not infrequently encountered in general surgical pathology. Extensive work in developmental and tumor molecular cell biology has elucidated potential molecular mechanisms responsible for epithelial-mesenchymal transition, a phenomenon postulated to be essential for systemic metastasis in non-central nervous system epithelial tumors. The existence of epithelial-mesenchymal transition is an area of intense debate within the cancer research community and has been extensively reviewed elsewhere. (39-42) The possibility of an analogous role of epithelial-mesenchymal transition in GS is currently unexplored. Regardless, it is clear that the metaplastic component in GS is neoplastic and frequently harbors cytogenetic and molecular abnormalities similar to those found in the glial component. In this regard, GSs are genetically similar to primary GBMs: 20% to 40% of tumors harbor TP53 mutations, PTEN deletions, and CDKN2A deletions. The only exception to this generalization is the relative infrequency of EGFR amplification in these tumors. (10,43) The notion that the sarcomatous element represents mesenchymal metaplasia analogous to that seen in carcinosarcomas elsewhere in the body comes from data demonstrating the presence of 1 or more identical genetic aberrations in both elements from individual tumors; the latter supports a monoclonal process rather than a collision tumor. (43-45) Similarly, identical genetic alterations have been described in microdissected portions from the glial and epithelial elements of adenoid GBMs and GSs, suggesting that this too represents metaplasia. (46,47)
Additional variants of GBM have been described beyond those published in the 2000 WHO classification scheme. These include small cell astrocytomas (SCAs), glioblastoma with oligodendroglial features (GBM-O), and GBM with primitive neuronal (primitive neuroectodermal tumor [PNET]-like) features. In contrast to granular cell astrocytoma, GC-GBM, and GS, all of which pose little diagnostic difficulty for the experienced neuropathologist on routine histopathologic examination, these variants have significant morphologic overlap with other recognized clinicopathologic entities, particularly HGO neoplasms. Identification of signature molecular genetic alterations, specifically codeletion of material on chromosomes 1p and 19q, and its association with responsiveness to adjuvant therapy and improved prognosis, has made accurate histopathologic and molecular genetic characterization of these neoplasms of paramount importance for proper treatment planning and precise prognostication. (48-51) Codeletion of 1p/19q has been shown to occur most frequently (50%-80%) in morphologically classical AO. (52,53) A subset (~20%) of AOA also harbor 1p/19q co-deletion, (50) although its prognostic utility remains less well defined for these neoplasms. Even when histopathologic classification is refined by ancillary molecular genetic analyses, diagnostic discrepancies remain frequent for the HGO neoplasms, even among experienced neuropathologists. (11,13-15,54)
Small Cell Astrocytoma
Small cell astrocytoma is a variant of GBM with considerable morphologic overlap with AO on routine hematoxylin-eosin-stained sections. (55,56) The histopathologic hallmarks of this tumor are its bland nuclear cytology and striking mitotic activity (Figure 7, A and B). It is composed of a large (>80%) monotonous collection of astrocytes with small, uniformly oval nuclei with mild hyperchromasia and minimal discernible cytoplasm. Like other diffuse gliomas, SCA can show cortical infiltration and secondary structuring, including perineuronal satellitosis (Figure 7, C). The tumor vasculature is sometimes composed of a delicate, chicken-wire capillary network (Figure 7, D). Immunohistochemical studies are a useful adjunct in diagnosing SCA: Tumor cells typically contain long, thin, GFAP-positive cytoplasmic processes (Figure 8, A) and a markedly elevated MIB-1 (Ki-67) labeling index (Figure 8, B).
In contrast to AO, in which median OS ranges from 5 to 10 years, the clinical behavior of SCA is much more aggressive, with median OS virtually indistinguishable from conventional GBM. (55,56) It is for this reason that accurate diagnosis of SCA is imperative for accurate prognostication and proper treatment planning. Our experience with 21 SCAs (4.6% of 453 newly diagnosed, adult supratentorial GBMs) at Washington University School of Medicine is listed in Table 2. These patients were of similar age to those with conventional GBMs. Their median OS was 14.3 months and was not statistically significantly different (log-rank P = .95) from that of conventional GBM after adjusting for patient age and surgery type.
Identification of characteristic molecular genetic alterations in SCA has provided an additional diagnostic aid in challenging cases. In contrast to AO, SCAs rarely harbor deletion of either 1p or 19q and we have never encountered codeletion of these chromosomes (Table 1). Rather, SCAs show chromosome EGFR amplification and chromosome 10q (PTEN) deletion, with frequencies even higher than conventional GBMs (Table 1). Combined EGFR amplification and 10q deletion is likewise more prevalent in SCA compared with conventional GBM. We have recently analyzed the diagnostic utility of molecular genetic analysis in the diagnosis of SCA. (57) Among 239 diffuse, high-grade gliomas (HGGs, including AAs, GBMs, AOs, and AOAs) analyzed by fluorescence in situ hybridization (FISH) for EGFR amplification, including 108 SCAs, the sensitivity and specificity for the diagnosis of GBM were 54% and 94%, respectively. EGFR amplification was equally sensitive (92%) and slightly more specific (64%) for SCA (Figure 8, C). Among 222 HGGs with 106 SCAs that were analyzed for 10q abnormalities by FISH, the sensitivity and specificity of 10q deletion for the diagnosis of GBM were 81% and 71%, respectively. 10q deletion was slightly more sensitive (90%) but slightly less specific (64%) for the diagnosis of SCA (Figure 8, D). Because these molecular genetic abnormalities may occasionally be found in other HGGs, FISH analysis does not serve as a replacement for routine histopathologic examination but only as an objective adjunct to confirm the initial morphologic impression of SCA or GBM in general.
GBM With Oligodendroglial Features
The current WHO classification of HGO neoplasms contains significant ambiguities. The 2 forms of HGO neoplasms, AO and AOA, are distinguished from their lowgrade counterparts, oligodendroglioma and oligoastrocytoma, by the presence of any one or more of the following histologic features: brisk mitotic activity, microvascular proliferation, and necrosis. No significant weight is given to any of these features, which has given rise to the following debate within the neuro-oncology community: Do grade IV variants of HGO neoplasms exist and, if so, what diagnostic features constitute such entities?
We recently performed a retrospective analysis of prognostic factors in 1093 newly diagnosed, adult supratentorial HGGs specifically to address this issue. (57) This study included 81 AAs, 581 GBMs (including 120 SCAs, 13 GSs, and 2 GC-GBMs), 215 AOAs, and 216 AOs diagnosed according to current WHO 2000 criteria. We considered the diagnosis of an AOA only if distinct astrocytic (Figure 9, A) and oligodendroglial (Figure 9, B) components were evident, either as geographically separated (Figure 9) or intermingled (not shown) areas. We found that the presence of any type of necrosis (Figure 9, A) in an otherwise grade III AOA was a strong predictor of poor survival independent of patient age (hazard ratio 2.4, 95% confidence interval 1.5-3.7, Cox P = .001): median OS for AOA patients whose tumors featured necrosis was 22.8 months, compared with 86.9 months for those without necrosis (log-rank P < .001). No significant effect of necrosis on median OS (89.8 months) was evident in patients with pure AO (log-rank P = .32). Moreover, the median OS of AOA with necrosis was closer to GBM (9.8 months) than to AOA without necrosis. Survival data for a subset of these GBM-O cases seen at Washington University School of Medicine is presented in Table 2. In this cohort of 27 patients (6% of 453 GBMs seen between 1990 and 2005), patient age was similar to that seen in GC-GBM, approximately 10 to 15 years younger than conventional GBM. Their median OS was 27.4 months, significantly longer than that for conventional GBM after correction for patient age and surgery type (P = .01).
We therefore consider WHO grade III AOA with necrosis to constitute a distinct grade IV variant of AOA and routinely designate such neoplasms as GBM-O. An alternative, equally valid designation would be highly anaplastic oligoastrocytoma, grade IV (MOA4). These tumors portend a significantly better prognosis than other variants of GBM, in line with the relatively better prognosis for oligodendroglial neoplasms in general.
In contrast to the finding of codeletions in roughly 85% of our AOs, deletion of either 1p (24%), 19q (43%), or combined 1p/19q (22%) is relatively infrequent in GBM-O (Table 1). Nonetheless, these frequencies are nearly identical to those we have encountered in mixed oligoastrocytomas overall. Interestingly, these tumors more frequently show solitary 19q deletion (21% of 58 analyzed tumors). Among 586 diffuse HGGs analyzed by FISH for 1p/19q abnormalities, the sensitivity and specificity of solitary 19q deletion for the diagnosis of AOA and GBM-O were 25% and 93%, respectively. Thus, the presence of solitary 19q deletion may be a useful molecular genetic feature to confirm the impression of a GBM-O after routine histopathologic examination, but its infrequent occurrence in these tumors precludes reliance on this feature in establishing the diagnosis.
GBM With Primitive Neuronal (PNET-like) Features
Rare examples of high-grade glioneuronal tumors or GBMs combined with cerebral neuroblastoma/supratentorial PNET have been previously published but remain relatively poorly characterized. (58) Similarly, we have encountered a number of such cases, often as consults with the differential diagnosis including an unusual GBM versus a supratentorial PNET with extensive glial differentiation (Figure 10, A). In support of the former interpretation, the majority of our cases have occurred in adults and had foci resembling conventional GBM, sometimes with foci of low-grade glioma in either the same or a prior biopsy. The primitive neuronal (PNET-like) element often looks like a separate clone with nodules of markedly increased cellularity, high nuclear-cytoplasmic ratios, markedly hyperchromatic cells, remarkably high mitotic and Ki-67 indices (close to 100% in some, Figure 10, D), and convincing evidence of neuronal or neuroblastic differentiation, such as Homer-Wright rosettes (Figure 10, B) and expression of neuronal antigens (eg, synaptophysin [Figure 10, C], Neu-N, neurofilament protein, neuron-specific enolase). To date, too few cases have been reported to determine the behavior or optimal therapy, although most of the patients we have encountered have died in less than a year, analogous to GBM in general.
Glioblastoma multiformes are morphologically diverse neoplasms with poor prognosis. Precise subclassification is becoming increasingly important, as several of the newly defined variants described since the publication of the WHO classification in 2000 have significant morphologic overlap with tumors that have more favorable prognosis and treatment response rates. Some of the variants described in this article have recently been added to the upcoming WHO 2007 scheme as distinctive "patterns" of GBM. More widespread application of the principles described in this review may permit more accurate prognostication and appropriate treatment planning in the future.
Supported in part by a cancer biology training grant from the National Cancer Institute, Bethesda, Md (grant T32CA009547 to C.R.M.).
(1.) Central Brain Tumor Registry of the United States: Statistical Report: Primary Brain Tumors in the United States, 1998-2002. Hinsdale, Ill: Central Brain Tumor Registry of the United States; 2006.
(2.) Bailey P, Cushing H. A Classification of the Tumors of the Glioma Group on a Histogenetic Basis With a Correlated Study of Prognosis. Philadelphia: JB Lippincott Co; 1926:175.
(3.) Kernohan JW, Mabon RF, Svien HJ, Adson AW. A simplified classification of gliomas. Proc Staff Meet Mayo Clin. 1949;24:71-75.
(4.) Ringertz J. Grading of gliomas. Acta Pathol Microbiol Scand. 1950;27:51-64.
(5.) Nelson DF, Nelson JS, Davis DR, Chang CH, Griffin TW, Pajak TF. Survival and prognosis of patients with astrocytoma with atypical or anaplastic features. J Neurooncol. 1985;3:99-103.
(6.) Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P. Grading of astrocytomas: a simple and reproducible method. Cancer. 1988;62:2152-2165.
(7.) Kim TS, Halliday AL, Hedley-Whyte ET, Convery K. Correlates of survival and the Daumas-Duport grading system for astrocytomas. J Neurosurg. 1991;74: 27-37.
(8.) Kleihues P, Burger PC, Scheithauer BW, Zulch KJ. Histological Typing of Tumours of the Central Nervous System. 2nd ed. Berlin, Germany: Springer-Verlag; 1993:xii, 112.
(9.) Zulch KJ. Histological Typing of Tumors of the Central Nervous System. Geneva, Switzerland: World Health Organization; 1979.
(10.) Kleihues P, Cavenee WK. Pathology and Genetics of Tumours of the Nervous System. Lyon, France: IARC Press; 2000:314. World Health Organization Classification of Tumours.
(11.) Brat DJ, Castellano-Sanchez A, Kaur B, Van Meir EG. Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation. Adv Anat Pathol. 2002;9:24-36.
(12.) Brat DJ, Van Meir EG. Glomeruloid microvascular proliferation orchestrated by VPF/VEGF: a new world of angiogenesis research. Am J Pathol. 2001;158: 789-796.
(13.) Aldape K, Simmons ML, Davis RL, et al. Discrepancies in diagnoses of neuroepithelial neoplasms: the San Francisco Bay Area Adult Glioma Study. Cancer. 2000;88:2342-2349.
(14.) Coons SW, Johnson PC, Scheithauer BW, Yates AJ, Pearl DK. Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas. Cancer. 1997;79:1381-1393.
(15.) Prayson RA, Agamanolis DP, Cohen ML, et al. Interobserver reproducibility among neuropathologists and surgical pathologists in fibrillary astrocytoma grading. J Neurol Sci. 2000;175:33-39.
(16.) Ohgaki H, Dessen P, Jourde B, et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res. 2004;64:6892-6899.
(17.) Mallory FB. The Principles of Pathologic Histology. Philadelphia, Pa: WB Saunders Co; 1914:1, 11-677.
(18.) Burger PC, Kleihues P. Cytologic composition of the untreated glioblastoma with implications for evaluation of needle biopsies. Cancer. 1989;63:2014-2023.
(19.) Nissl F. Zur histopathologie der paralytischen Rindenerkrankung. Histol Histopathol Arb Grosshirn. 1904;1:315.
(20.) Reis RM, Hara A, Kleihues P, Ohgaki H. Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas. Acta Neuropathol (Berl). 2001;102:422-425.
(21.) Kros JM, Waarsenburg N, Hayes DP, Hop WC, van Dekken H. Cytogenetic analysis of gemistocytic cells in gliomas. J Neuropathol Exp Neurol. 2000;59: 679-686.
(22.) Krouwer HG, Davis RL, Silver P, Prados M. Gemistocytic astrocytomas: a reappraisal. J Neurosurg. 1991;74:399-406.
(23.) Watanabe K, Peraud A, Gratas C, Wakai S, Kleihues P, Ohgaki H. p53 and PTEN gene mutations in gemistocytic astrocytomas. Acta Neuropathol (Berl). 1998;95:559-564.
(24). Kosel S, Scheithauer BW, Graeber MB. Genotype-phenotype correlation in gemistocytic astrocytomas. Neurosurgery. 2001;48:187-193; discussion 193-184.
(25.) Avninder S, Sharma MC, Deb P, et al. Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations-a study of 32 cases. J Neurooncol. 2006;78:123-127.
(26.) Tihan T, Vohra P, Berger MS, Keles GE. Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspective. J Neurooncol. 2006;76:175-183.
(27.) Watanabe K, Tachibana O, Yonekawa Y, Kleihues P, Ohgaki H. Role of gemistocytes in astrocytoma progression. Lab Invest. 1997;76:277-284.
(28.) Brat DJ, Scheithauer BW, Medina-Flores R, Rosenblum MK, Burger PC. Infiltrative astrocytomas with granular cell features (granular cell astrocytomas): a study of histopathologic features, grading, and outcome. Am J Surg Pathol. 2002;26:750-757.
(29.) Geddes JF, Thom M, Robinson SF, Revesz T. Granular cell change in astrocytic tumors. Am J Surg Pathol. 1996;20:55-63.
(30.) Castellano-Sanchez AA, Ohgaki H, Yokoo H, et al. Granular cell astrocytomas show a high frequency of allelic loss but are not a genetically defined subset. Brain Pathol. 2003;13:185-194.
(31.) Chorny JA, Evans LC, Kleinschmidt-DeMasters BK. Cerebral granular cell astrocytomas: a Mib-1, bcl-2, and telomerase study. Clin Neuropathol. 2000;19: 170-179.
(32.) Meyer-Puttlitz B, Hayashi Y, Waha A, et al. Molecular genetic analysis of giant cell glioblastomas. Am J Pathol. 1997;151:853-857.
(33.) Peraud A, Watanabe K, Schwechheimer K, Yonekawa Y, Kleihues P, Ohgaki H. Genetic profile of the giant cell glioblastoma. Lab Invest. 1999;79:123-129.
(34.) Shinojima N, Kochi M, Hamada J, et al. The influence of sex and the presence of giant cells on postoperative long-term survival in adult patients with supratentorial glioblastoma multiforme. J Neurosurg. 2004;101:219-226.
(35.) Fujita M, Mizuno M, Nagasaka T, et al. Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies. J Neurosurg. 2004;101:1012-1017.
(36.) Maeda K, Mizuno M, Wakabayashi T, et al. Morphological assessment of the development of multinucleated giant cells in glioma by using mitosis-specific phosphorylated antibodies. J Neurosurg. 2003;98:854-859.
(37.) Araki K, Nozaki K, Ueba T, Tatsuka M, Hashimoto N. High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas. J Neurooncol. 2004;67:53-64.
(38.) Galanis E, Buckner JC, Dinapoli RP, et al. Clinical outcome of gliosarcoma compared with glioblastoma multiforme: North Central Cancer Treatment Group results. J Neurosurg. 1998;89:425-430.
(39.) Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2:442-454.
(40.) Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol. 2006; 172:973-981.
(41.) Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene. 2005;24:7443-7454.
(42.) Tarin D, Thompson EW, Newgreen DF. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res. 2005;65:5996-6000; discussion 6000-6001.
(43.) Reis RM, Konu-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H. Genetic profile of gliosarcomas. Am J Pathol. 2000;156:425-432.
(44.) Actor B, Cobbers JM, Buschges R, et al. Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components. Genes Chromosomes Cancer. 2002;34:416-427.
(45.) Paulus W, Bayas A, Ott G, Roggendorf W. Interphase cytogenetics of glioblastoma and gliosarcoma. Acta Neuropathol (Berl). 1994;88:420-425.
(46.) Ozolek JA, Finkelstein SD, Couce ME. Gliosarcoma with epithelial differentiation: immunohistochemical and molecular characterization: a case report and review of the literature. Mod Pathol. 2004;17:739-745.
(47.) du Plessis DG, Rutherfoord GS, Joyce KA, Walker C. Phenotypic and genotypic characterization of glioblastoma multiforme with epithelial differentiation and adenoid formations. Clin Neuropathol. 2004;23:141-148.
(48.) Bauman GS, Ino Y, Ueki K, et al. Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas. Int J Radiat Oncol Biol Phys. 2000;48:825-830.
(49.) Cairncross JG, Ueki K, Zlatescu MC, et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst. 1998;90:1473-1479.
(50.) Perry A, Fuller CE, Banerjee R, Brat DJ, Scheithauer BW. Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics. Front Biosci. 2003;8:a1-9.
(51.) Smith JS, Perry A, Borell TJ, et al. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas. J Clin Oncol. 2000;18:636-645.
(52.) Burger PC. What is an oligodendroglioma? Brain Pathol. 2002;12:257-259.
(53.) Burger PC, Minn AY, Smith JS, et al. Losses of chromosomal arms 1p and 19q in the diagnosis of oligodendroglioma: a study of paraffin-embedded sections. Mod Pathol. 2001;14:842-853.
(54.) Perry A. Oligodendroglial neoplasms: current concepts, misconceptions, and folklore. Adv Anat Pathol. 2001;8:183-199.
(55.) Perry A, Aldape KD, George DH, Burger PC. Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma. Cancer. 2004;101:2318-2326.
(56.) Burger PC, Pearl DK, Aldape K, et al. Small cell architecture--a histological equivalent of EGFR amplification in glioblastoma multiforme? J Neuropathol Exp Neurol. 2001;60:1099-1104.
(57.) Miller CR, Duhnam CP, Scheithauer BW, Perry A. Significance of necrosis in grading of oligodendroglial neoplasms: a clinicopathologic and genetic study of newly diagnosed high-grade gliomas. J Clin Oncol. 2006;24:5419-5426.
(58.) McLendon RE, Provenzale J. Glioneuronal tumors of the central nervous system. Brain Tumor Pathol. 2002;19:51-58.
Accepted for publication October 25, 2006.
From the Division of Neuropathology, Washington University School of Medicine, St Louis, Mo.
The authors have no relevant financial interest in the products or companies described in this article.
Reprints: Arie Perry, MD, Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box 8118, St Louis, MO 63110 (e-mail: firstname.lastname@example.com).
Table 1. Clinicopathologic and Molecular Genetic Features of Glioblastoma Multiforme (GBM) Variants * Tumor Feature Primary (16) Secondary (16) Fib Peak age (decade) 6-7 5-6 6-7 Circumscription ... ... - Nuclear irregularity ... ... ++ Perinuclear haloes ... ... - Cytoplasmic granules ... ... - Multinucleated cells ... ... +/- Reticulin meshwork ... ... - PVI ... ... +/- Mucin-filled microcysts ... ... +/- 1p del, % ... ... ... 19q del, % ... ... ... 1p/19q codel, % ... ... ... EGFR amp, % 36 8 ... 9p (CDKN2A) del, % 31 19 ... 10q (PTEN) del, % 70 4 ... EGFR amp/10q del, % ... ... ... TP53 mut, % 28 65 ... PTEN mut, % (43) 32 4 ... Tumor Feature Gem GCA GC32 Peak age (decade) 6-7 6-7 5-6 Circumscription - +/- + Nuclear irregularity + +/- +++ Perinuclear haloes - - - Cytoplasmic granules - + - Multinucleated cells +/- +/- +++ Reticulin meshwork - +/- +/- PVI ++ +/- + Mucin-filled microcysts - - - 1p del, % ... ... ... 19q del, % ... ... ... 1p/19q codel, % ... ... ... EGFR amp, % ... ... 5 9p (CDKN2A) del, % ... ... 0 10q (PTEN ) del, % ... ... 5 EGFR amp/10q del, % ... ... ... TP53 mut, % ... ... 89 PTEN mut, % (43) ... ... 27 Tumor Feature GS (43) SCA (57) GBM-O (57) Peak age (decade) 6-7 6-7 5-6 Circumscription + - - Nuclear irregularity ++ +/- + Perinuclear haloes - - ++ Cytoplasmic granules - - - Multinucleated cells +/- +/- +/- Reticulin meshwork +++ - - PVI +/- +/- +/- Mucin-filled microcysts - - ++ 1p del, % ... 3 24 19q del, % ... 6 43 1p/19q codel, % ... 0 22 EGFR amp, % 4 63 7 9p (CDKN2A) del, % 37 ... ... 10q (PTEN ) del, % ... 89 27 EGFR amp/10q del, % ... 56 4 TP53 mut, % 23 ... ... PTEN mut, % (43) 38 ... ... Table 2. Prognostic Impact of Morphologic Variants in 453 Newly Diagnosed, Adult (> 20 y) Supratentorial Glioblastoma Multiformes (GBMs) at Washington University School of Medicine (1990-2005) * Tumor Characteristic GBM GC-GBM GS n 388 7 10 % 85.7 1.5 2.2 Mean age, y 61.6 52.1 59.1 Resection, % 64 57 90 Median OS, mo 9.3 11.4 7.6 Log-rank P (vs GBM) ... .48 .33 Tumor Characteristic SC-GBM GBM-O n 21 27 % 4.6 6.0 Mean age, y 57.6 47.9 Resection, % 91 93 Median OS, mo 14.3 27.4 Log-rank P (vs GBM) .95 .01 * P adjusted for patient age and surgery type. GC-GBM indicates giant cell GBM; GS, gliosarcoma; SC-GBM, small cell GBM; GBM-O, GBM with oligodendroglial features; and ..., no data available.
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text: <jasonpsage <at> jegas.com> writes: > > Has anyone received an error with core utils resembling: > > make[3]: Entering Directory `/mnt/lfs/sources/coreutils-8.14/src' > CC expr.o > expr.c:54:18 fatal error: gmp.h: No such file or directory > compilation terminated. > > Is there perhaps a dependancy not in the list of files we are to > download maybe? I did all the Errata patches and stuff... so I'm > puzzled... (which isn't a new thing) but still... (B^)> > > Thank You! > --Jason > Edit src/Makefile and add "-I/xxx" where xxx is your gmp include path to CFLAGS. Mine looks like: CFLAGS = -g -O2 -I/usr/gnu/gmp-5.0.3/include I completed the build on Solaris 11 x86


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Pacific Coast News, Courtesy of Summit
As the romance continues to return in Rob and Kristen's relationship, we've gathered the most romantic things each have done for the other in the aftermath of Kristen's affair! Read on for details and to see the photos!
We're so happy that Robert Pattinson and Kristen Stewart are slowly reconciling their relationship! After Kristen's affair with Rupert Sanders, she and Rob had several moments that indicated the romance between the two wasn't completely dead, and we've gathered the most romantic of the moments!
Take a look at our gallery and let us know, HollywoodLifers, which moment do you think was the most romantic?
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More Rob and Kristen News:
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United Nations Development Programme
The 2000/2001 Namibia NHDR focuses on Gender and Violence and its impact on Namibian society.
The precarious living conditions of the majority of Mozambicans may first lead to the erroneous perception that the differentiated analysis of the HD of men and of women is a forced exercise, limited only to the agendas of those who wish to follow the fashion in contemporary social debate, by dea
This report addresses three different but closely tied subjects. The focus of analysis bears on women issues in Guatemala, at three key stages in their life cycle: childhood and adolescence, adulthood and the third age.
The "Human Development Report El Salvador 2003" is composed of 3 parts.
The 2003 NHDR deals with "Gender, Human Development and Poverty". The report tackles the gender issue from two angles: "how is gender equality affected by the human development issue" and "what is the impact of gender equality on the human development situation".
Montenegrin Report highlights three major issues - inequality, gender and poverty. Inequality proves to be concerning global issue. Ten percent of world's richest account for 54% of global income.
The Albania NHDR 2005 focus on Pro-Poor and Pro-Women HD issues through surveys and research at the local level dealing with perceptions on poverty and gender issues.
The Human Development Strategy, while providing people with opportunities to develop their capacities, must place people at its center and, as such, give high priority to gender equality since gender equality really represents a keystone of human development that stresses sustainable productivity
Le rapport présente l'évolution récente de l'indice du développement humain (IDH) et de ses différentes composantes pour l'Algérie.
Le Programme des Nations Unies pour le Développement, en accord avec le Gouvernement comorien, a soutenu l'élaboration de ce rapport consacré à la problématique " genre et développement humain" dans le but de promouvoir le débat national et catalyser l'action pour faire avancer le développement d


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Three MLAs of the Telangana Rashtra Samithi (TRS) suddenly staged a dharna at the entrance of the Chief Minister's office, inside the Secretariat, for about 15 minutes on Thursday afternoon.
Eatala Rajender, TRS floor leader in the Assembly, T. Harish Rao and Ravindra Reddy, MLAs, had gone to the Secretariat to lodge a complaint with Chief Minister K. Rosaiah against the dual standards adopted by police in dealing with the agitation in Telangana and in Coastal Andhra and to demand withdrawal of cases registered against students in the Telangana region.
The TRS leaders recalled that while their party president K. Chandrasekhar Rao was prevented by police from undertaking a fast in Siddipet and arrested whereas Congress MP L. Rajagopal and TDP MLA were allowed to launch hunger strikes in Vijayawada. Mr. Rosaiah must answer whether he was Chief Minister for the entire State or just for the Coastal Andhra and Rayalaseema regions, they said.
Meanwhile, as police moved in to take the MLAs into custody, the Chief Minister sent word inviting them to his chambers for discussions. They promptly ended their sit-in and walked to the CM's office.
Keywords: TRS MLAs, dharna, Secretariat, cases, withdrawal, students, Hyderabad


text: On Wed, 23 Jul 2003, Declan. Moriarty wrote: > I hit 'make' again, and it's off for another 10 minutes. It's the > same tar.bz2 that I compiled earlier, the memory is recently > tested good, and the compiler has never done this before. I'm > using qt-x11-free-3.0.5, and gcc-2.95-3, cos I never updated from > lfs-3.3. > > And every time I switch on or off my desk lamp, the pc reboots > :-((. It seems the bulb or the starter is gone awol. I personally > suspect senile dementia in the bulb ;-). Do you have a nice weather in Ireland at the moment? 'Cause if it's rather hot, that could explain both your make failures (and cleaning the cpu cooler might help) and your desk lamp behaviour (a cold shower (for you, not the lamp) might help with this one)... uli -- Uli Fahrenberg -- http://www.math.auc.dk/~uli -- Unsubscribe: send email to listar at linuxfromscratch.org and put 'unsubscribe blfs-support' in the subject header of the message