text:
how long can you leave a cat home alone
I have a question! I spend the night with my friend who lives 2 hours away about once a week. I usually am gone for about 28 hours. I fill both sides of Jasper's food bowl up with dry food, and make sure the autowaterer is filled with fresh water before I go. I scoop the litter daily, but change it the day I leave for my friends house. I've done this since I've had him, so that's about five months now (which means he's 11 months old... boy how time flies!). I close the bedroom door, and make sure to dig his toys out from under the sofa before I go. When I get home, he is much more affecionate than normal. I will fill his food bowl up as soon as I get home, and he doesn't even go for it. He just kisses me and purrs and climbs all over me. I think he misses me as much as I him... the food obviously isn't an issue. I had considered buying an auto (gravity) feeder, but I don't believe in free feeding. Nothing has ever been destroyed or ruined, so that makes me trust him. Just wondering how long it is acceptable to leave a cat for. What do you think is safe/humane? I am going to spend a weekend next week away, but I'm taking Jasper with me. I can't be without him too long, and I know a whole weekend would be too much... if I leave Friday night and come back Monday morning, I better take him. How do I make the car trip (2 hours is a long time in a kitty carrier) easier for him? My friend loves Jasper, though doesn't have any pets of his own. He will be babysitting his mothers cat as well at that time, and the two have never met, so that will be interesting. Not the way I'd prefer to do things, but that's when my days off fall next week. The mom's cat is an older neutered male with shots... but very independent. So, I'm not worried about the transferring health issues... but what about sharing the litter box? What do you think? Thanks for any advice. Sure hope the older grouchy cat doesn't teach my sweety baby any bad habits!
I've always been able to leave my cats for a full weekend. Friday to sunday anyways. But at the same time, I have two. They keep eachother so busy I doubt they really even realise we're gone. Also I have two friends with two spare keys for letting the dogs out when we go on day trips out of town. So if ever need be, they could go check on the cats for me. My cats have always been fine. Definately more affectionate and happy to see us, but they never seem stressed.
My sisters cat on the other hand, will loose all the fur on his tail if he's left alone for more than one night. He gets very very stressed, so now they take the kitties to her MILs house when they go away for longer than one night.
My calico is pro at being alone. Right after my father died, I went to stay two hours away with my sister for a week. I had someone come feed her and give her loves, and change the box. But for the most part she was alone. I would've taken her with me, but I think for her the stress of a car ridex2 plus two new kitties to deal with when she'd never even seen another animal would have been much more than staying at home for 5 days. It barely seemed to phase her.
As far as sharing the litter box, you may only have to worry if the cats really dont get along. Yours may hide and not want to come out, or the other may hide. The older kitty might hate sharing or vice versa. It might be best to pick up one of the cheap small litter boxes, just incase. They even make disposable litter boxes now, though I have no idea if they work well or not. I have no idea how to make the car trip easier. My calico cant stand being in the car. Our vet is not even a two minute drive away and sometimes I swear she thinks its going to kill her. She starts losing fur like crazy and howling and shaking. The vets recommended sedatives, but I'd prefer not to sedate my cats, and just leave them at home.
My cats are easy also because I have 4. They all keep each other company but I have never left them longer then a weekend. I think that 2 nights and 3 days is OK, as long as you have somebody come and check on them, make sure everything is okay and give them some love. My persian kitty is in heat about every other week, so just depending on if I leave on that week will depend on if somebody needs to go over and love on her and them.
Now, mixing the cats...I strongly suggest you be CAREFUL!! My cats are all used to being around each other and they are all fine with other cats but, my mom was moving to a new apartment one weekend and I told her she could bring her kitty over while she moved (for less stress on the kitty). Well she did and I stayed there with all of them for a while to make sure everything was okay and thank goodness I did. Well Seehr(my moms cat) freaked out!! She hissed, bit, scratched anything she could to whoever she could. She started hissing and biting at me when I tried to calm her down and when my persian saw that she freaked out. She did not like to see another cat smacking mommy. So they started in to it and lets just say, I got the worst of it because I jumped right in the middle of them. No way was I going to let them fight it out, so I got it. lol So how many people are laughing right now picturing this in your head??? lol :-) Tiny me, at home by myself, and the cats are fighting my dog watching (I have a boxer), and me bloody!! lol It does sound funny looking back!!! :-) Just be careful!!! Please??? For your babies sake, because you really don't know how she/he will react to another cat next to her owner.
Please post and let us know how it went!!! :-) Have a good trip!!
Thanks, Elycia
How long a cat can be left alone, probably depends upon the personality of the cat.
A weekend with automatic food and water is probably fine for most cats. And with a neighbor or friend checking on the animal each day - they could probably go even longer.
I think the biggest concern is the litter box. If you have someone who will come and change the litter and spend some play time with kitty then you could be gone idefinitely.
I think the biggest issue is where they would sleep. I enjoy having my Jasper in bed with me every night... my friend doesn't think animals belong in bed. If we ever get "serious" we (HE)will have to compromise (give in). Thanks for advice... I will post outcome!
The longest we have left ours was for about 4 days.
I heard somewhere that turning on the radio or tv and leaving it on for the cat at a low volume can help with their loneliness while you're gone. It is reassuring to them and soothing to hear the human voices.
I think as long as they have food and water,most cats are ok.They are much less needy then dogs and can usually find ways to entertain themselves.But...it's nice to know you are missed when gone!
Personally, I would leave Jasper at home for the weekend rather than subject him to a two hour car ride each way and then being subjected to a strange place and strange feline on top of it all. That is, if I'm reading your post correctly. My cats yowl the whole eight minute drive to the vet's office...I don't know what Jasper is like in that area. Ask a neighbor to pop in once over the weekend and scoop his litter box, that should be sufficient.
I've left my eight cats for two days and one night, but not since I've had the kitten. I fed them wet food in the morning I left and had bowls of dry and four water dishes which I always have anyway and they have eight litter boxes so all was well. I wouldn't go for longer with out someone coming in.
I agree with Junebug. I think it would be way to stressful for Jasper.
If you can't get a neighbor to clean the litter box once you could get a second one for the weekend.
We have two at the moment but had three for along time. The longest we left them alone is 5 days. Lots of food and several litter boxes. They seemed to have no ill effects.
I agree with junebug as well. Cat's don't handle travel, changes, etc the way dogs do. I would think that the travel, strange house, strange cat would be very hard for Jasper. Might spend most of his time stressed out or hiding.
Me personally, I wouldn't leave for longer than a weekend with no one checking on mine. I would be just too worried - which doesn't mean they wouldn't be OK. But we have relatives down the street that can peek in on them if we needed to be gone longer than a weekend.
How is he travelling?
I agree with junebug. Leave him in his comfortable home and don't chance upsetting the balance. You also need to consider the other cat...........the visit from a strange cat may start some unwanted behaviors and your weekend could be ruined by cats that are fighting.
Also.............how does the Mom feel about another cat coming into her home? Personally, I wouldn't be happy about it.
Leave extra bowls of food, a second litter box, a radio or TV on and all should be fine.
Jasper doesn't love to travel, he cries in the car. Even for short distances, so maybe it would be less stressful for all parties to leave him alone if I just prepare the place properly first. Annz... Mom's cat is at my friend's house... not hers! She wouldn't know about my cat interacting with her cat because she doesn't know about me... her son, my friend isn't "out of the closet" yet, so I'm a secret for now. But that's a whole other discussion! Thanks for all the advice!
I agree that if your cat isn't used to traveling, leave him home. I think the longest I've left my cats for was around a little over a week, maybe 8 or 9 days - I really don't remember. We had neighbors come and check on them every day, and feed them and such. They did fine. I wouldn't make a habit of it though.
There was a lady that came into the nursery I work at looking for flea control for her cat and her home. One of the things I recommended was to vacuum every day. She said she couldn't ask her neighbor to do that. Turns out the lady was a flight attendant and was only home 1 or 2 days a week - the neighbor took care of the cat the rest of the time. That, to me, is abuse. That, to me, is her neighbor's cat that just happens to live in her house. Sad. But, that's not what you're doing.
Thinking of traveling with cats reminds me of the book, "The Cat Who Went to Paris." I don't remember the author's name, but it was a non-fiction account of his life with his cat, and how they went everywhere together. It's an amusing book that I recommend to cat lovers.


text:
I order all my magical items exclusively from MJM Magic. I know that I hit overdrive and lose it if I were to look at all the other online magic...Read More ->
I was having a problem filling out my order so I decided to send an email. I may have been lucky due to the time I contacted, but I received a...Read More ->

subset: commoncrawl


text:
We would love to host you on our beautiful seaside campus in Biddeford, Maine. We will be happy to set up an individual appointment for you during the week.
In the summer months, we also offer a series of Open House events that provide you and your family a chance to visit campus and learn more about what makes our College of Osteopathic Medicine a special place to learn and grow.
If you are unable to visit, or just beginning your search, please check to see if an Admissions representative will be visiting a place near you.
Open House
If interested in attending, please RSVP to email@example.com by the end of business on Friday prior to the event date, to save your seat! Please include which date you wish to visit, your contact information, year of desired entry to medical school, number of guests in your party, and if you wish to take advantage of our offer to meet with an Admissions Representative. Once you have registered, we will send you more specific information for your trip to campus. We look forward to hosting you and answering your questions!
Stay tuned for future Open House dates
If you are interested in attending, please RSVP to email@example.com.
Open House events introduce you to:
- The admissions process and curriculum
- A "Day in the Life" of a medical school student
- Our beautiful seaside campus
- Faculty, who engage you in one-on-one meetings
- Current COM students
- Admissions representatives (optional/upon request)


text: ilja wrote: > Strange though about the In-Reply-To. The thing is that I don't reply, I > just start a new message and write in the subject: > RE: ........ (in this case:'Re: what does it take?') > is this a proper way to reply? No, of course not. That's why there is "Reply" function in the MUA, so that you can reply and maintain continuity. Why would you choose to do it the harder way?


text:
Reader comments are listed below. Comments are currently closed and new comments are no longer being accepted.
Yes there are problems, and yes they have all not been solved, and yes the educational system needs herculean overhauling, and yes corruption and graft are rampant.... almost to the point of being organically "ingrained". BUT, while all of this is true, it is good to recognize that it is easy to destroy things, it is very difficult to rebuild. And when you have been doing anything and everything to survive, most of which have very little to do with honesty and/or integrity, and that continues for more than a decade, with little or no oversight, or accountability, with limited ability or will to enforce the rule of law, the abnormal becomes normal.... a way of life. Transformation from the "new normal" is going to be a long hard road; it will require everyone putting her/his shoulder behind the wheel.
I have hope, and I have no doubt that change for a better Liberia is on the way (actually, on a fast track). The UL entrance exam outcome is a wake-up call, that reflects on just about everything that has happened to Liberia the last 15+ years. We are now in the last stage of Elizabeth Klübler-Ross' 5-stages of grief (denial, anger, bargaining, depression, and ACCEPTANCE); people are beginning to really discuss, beginning to recognize root causes, beginning to look for sustainable solutions. I am hopeful, actually convinced that this wakeup call is going to be transformational to Liberia's recovery...the spark plug to many changes-for-the-better that will emerge in Liberia.
Five years from now, people will marvel at the Liberia that will have emerged!
The article in the Economist could have said all of the same things, but differently. Anyone who really cares about Liberia, with all of the changes that have taken place in the last five-year, would have written an ENCOURAGING article, not one that ends with such a negative tune.
Ophelia Weeks, Private Citizen
p.s. As Dean of the T.J.R Faulkner College of Science & Technology at the University of Liberia, I encourage anyone who is interested in advancing educational efforts in Liberia, to underwrite the cost of renovating our science building, fund a science library, equip a biology, chemistry, physics or computer lab.
Point of correction..Madame Ellen Sirleaf has not kept Liberia at peace, instead credit goes to the international peace keepers maintaining the fragile for the past 15yr while she continued to appoint warlords as a form of reconciliation without discussing the cardinal issue of justice for war crimes. Doing so will implicate her so she continued to avoid this discussion. Ellen Johnson Sirleaf is a chief financier of the 14yr brutal civil war which caused the death of more 250,000 Liberians and 5 Nuns. The female president is the axis of evil and does not represent African women on the continent; however she has successfully manipulated donors in the international communities to amassed wealth for herself and families...
I guess Bono'e dark glasses kept him from seeing the piles of garbagee on the streets and theose same glasses must have helped him to see in the dark as 80% of the country lacks electricity and pipe borne water. Ellen rewards her cronies and all her sons are in government. peace, really? Peace at any price???
Buttonwood's notebook
Lithuanian politics: Stirring the pot
Q&A: Harry Melling: What Dudley did next
Daily chart: Uptown top ranking
Graphic detail
The Economist explains: Why Binyamin Netanyahu is giving a speech to...
The Economist explains
Argentine intrigue: Case dismissed
The Americas
America and Israel: Lofty ideas, low politics
Democracy in America
Have you listened to The Economist Radio on Facebook?
The Economist Radio is an on-demand social listening platform that allows you to listen, share and recommend The Economist audio content
Test your EQ
Take our weekly news quiz to stay on top of the headlines
In Other Words
Try our new audio app and website, providing reporting and analysis from our correspondents around the world every weekday
Want more from The Economist?
Visit The Economist e-store and you'll find a range of carefully selected products for business and pleasure, Economist books and diaries, and much more


text:
I want to know what the most reliable and accurate pistol is. (calibers 40s&w 45 or 9mm)
Guns don't kill people, Chuck Norris does. XD
Join FirearmsTalk.com Today - It's Free!
Are you a firearms enthusiast? Then we hope you will join the community. You will gain access to post, create threads, private message, upload images, join groups and more. Firearms Talk is owned and operated by fellow firearms enthusiasts. We strive to offer a non-commercial community to learn and share information.
Join FirearmsTalk.com Today! - Click Here
There's no overall best firearm let alone handgun. There are some many factors like what the firearm is going to be used for, personal preference, and ect. All mechanical devices are subject to breakage, malfuction, and what not. They can and will malfuction at some point.
"It's a gun you loaded on Sunday, and shot all week." -Confederate Soldier "If God didn't create man equal then Sam Colt had made them equal." -Unknown "Fast is fine, but accuracy is everything." -Wyatt Earp
Well can u name off some really good quality pistols
Hi rem. I suggest scanning through previous threads - no offense to you but there is considerable discussion on just that topic. From lists created by users by caliber, size, frame style, and a whole lot more. I am partial to full-sized pistols myself and own a few at that but it sort of depends on what its intended role is to be. For example I carry a Kahr K9 and have for about 8 years. It's small and solid but not the pleasure to shoot that my others are but I trust it. Would I put it in the top of a list? Well, mine I guess. See what I mean? Good luck on your search and remember that another's opinion is just that - an opinion :-)
I could make a list of a bunch of guns i have, or "have", or wish I had. Why would one feel compelled to provide that infornation freely? Do you feel the need to show off? Is it some immature game of oneupsmanship? Why do you feel it necessary to list your guns?
Willfully armed knows his guns. All those make great targets.
Most shooters are bound to be more accurate with a certain platform than the next. And most decent guns are far more accurate than the shooters behind them are capable of displaying. If you're on an unlimited budget, I think a Sig P210 (9mm) or P226 X5 (9mm/40sw) would be tough to beat. The same for a lot of the higher end 1911s in 45acp. On a more modest budget, I like the CZ 75 series (9mm) and its variants. Some of the longslide (5"+ barrels) polymers are pretty decent. Browning Hi-Power or a standard Sig P226 are other options.
Yeah I dunno, to me that's like saying what is the coolest looking car? It seems very subjective. But like Sweeper said, it really depends on the person shooting it. You can give the worlds fastest car to an average driver and the worlds best driver in an average car will win 9 times out of 10. Same thing with guns (in my opinion, no one freak out on me ). If I had to pick one gun though, I would probably get a nice 1911, like a Kimber or a Nighthawk. Sig makes some perdy 1911's as well.


text:
What does DCCO mean in Internet?
This page is about the meanings of the acronym/abbreviation/shorthand DCCO in the field in general and in the Internet terminology in particular.
Dive Club Cologne Otters
Find a translation for DCCO in other languages:
Select another language:
Discuss this DCCO abbreviation with the community:
Use the citation below to add this abbreviation to your bibliography:
"DCCO." Abbreviations.com. STANDS4 LLC, 2015. Web. 28 Feb. 2015. <http://www.abbreviations.com/term/1432849>.
DCCO also stands for:
- Dah Chung Trading Company
- Dartmouth Club of Central Ohio
- Date of Commencement of Commercial Operations
- Defense Commercial Communications Office
- Double Crested Cormorant (phalacrocorax auritus)
... and 2 more »
Nearby & related abbreviations:
Alternative search:
- Search Dive Club Cologne Otters on Amazon
- Search Dive Club Cologne Otters on Google


text:
What does OFSA mean in Military?
This page is about the meanings of the acronym/abbreviation/shorthand OFSA in the Governmental field in general and in the Military terminology in particular.
Find a translation for OFSA in other languages:
Select another language:
Discuss this OFSA abbreviation with the community:
Use the citation below to add this abbreviation to your bibliography:
"OFSA." Abbreviations.com. STANDS4 LLC, 2015. Web. 6 Mar. 2015. <http://www.abbreviations.com/term/24980>.
OFSA also stands for:
... see them all »
Nearby & related abbreviations:
Alternative search:
- Search Objective Family of Small Arms on Amazon
- Search Objective Family of Small Arms on Google


text:
Level playing field
Level playing field
A new economic study details how a Massachusetts tax loophole is costing the state nearly 2,000 jobs and $387 million in lost sales tax revenue ("State treasurer seeks uniform Internet sales tax," Nov. 20). This is because online-only retail giants, such as Amazon.com, avoid the requirement to collect the state's sales tax.
The article you requested has been archived | |||


text:
Cemetery in Washington County, Minnesota, USA.
Latitude: 45.25333 : Longitude: -92.80694
Blogs and Websites Near Elim Cemetery, Minnesota - GeoURL
Elim Cemetery Map - Multimap
Elim Cemetery Street Map and Satellite Photo - Google Maps
Elim Cemetery Aerial Photo and Topo Map - Terraserver
Elim Cemetery Map - MSN
Environmental Hazards, Flood Area Maps, Boundaries - EPA
Elim Cemetery Area Map - MapQuest
Weather Forecast near Elim Cemetery - Multimap
The weather forecast links don't work for all places yet.
Some random places: Fund Pond Euell Cemetery Odra Nsuset Regional High School Nders Pond


text:
But WaitThere's More
Find other great ideas in these related stories:
- Must-See Christmas Trees Around the World ›
- 'Tis the Season ›
- Holiday Gift Guide ›
- Real-Life Holiday Movie Locations ›
- Winter Wonderlands ›
- 2011 Holiday Travel Gift Guide ›
- Creepy Road Trips ›
- The U.S.A.'s Weirdest Roadside Attractions ›
- The World's Best Places for Sin ›
- Abandoned Places: Ghosts of Vacations Past ›
- Romantic Travel Done Right ›
About an hour north of Cabo, this Mexican village is home to some of Baja's greatest waves. Start each day with some surfing at one of the area's—if not the country's—best breaks: San Pedrito. Then spend the afternoon exploring Todos Santos, a dusty little town filled with galleries, cafés, and boutiques. For a snack, try the ceviche at the stylish La Chulita food truck.


text:
Sorry about that! Not sure what happened!
You can either go over to the search bar—> over in the side bar and try again.
Or go to our Home Page, or Start Over.
Try using the search box over there—-> and try again!
The following two tabs change content below.
Hi, I'm Lisa, owner and main writer for this site. I live in Chester County, PA with my husband and two boys. I work PT as a Special Education Advocate and Disabilities Consultant, plus I have this blog and a weekly newspaper column. Thanks for reading!
Latest posts by Lisa (see all)
- Teaching Kids to Think~book giveaway - March 4, 2015
- getting kids to enjoy brushing and flossing - March 3, 2015
- PARC, Pennhurst and the most under utilized disabilities resource in Pennsylvania - March 3, 2015


text:
Can't win with 'em
Can't win without 'em
We've all heard of large-mouth and small-mouth bass. Only one place offers the double-mouth bass...
Another fine product caught in the Susquehanna River and sold at the "Three Mile Island" Fish Market.
Small market fan... always hoping, but never expecting.
Here we see the female.
'When I'm not longer rapping, I want to open up an ice cream parlor and call myself Scoop Dogg.'
-Snoop on his retirement
Your Mom is happy.
The O'Brien, Speckled Trout, Oncorhynchus mykiss "O'Briana".Originally Posted by Red Leader
Notice the slack jaw, the look of utter confusion.
Next Reds manager, second shooter. --Confirmed on Redszone.
Not really a caption,but it smells like our pitching.
0 Value Over Replacement Poster
"Sit over here next to Johnathan (Bench)...sit right here, he's smart."--Sparky Anderson
Dinner time.
Go Gators!
Wow! An "Alien" fish!
"panic" only comes from having real expectations
Reminds me of my first mother in law.
"Twenty years from now you will be more disappointed by the things that you didn't do than by the ones you did do. So throw off the bowlines. Sail away from safe harbor. Catch the trade winds in your sails. Explore. Dream. Discover."
~ Mark Twain
Board Moderators may, at their discretion and judgment, delete and/or edit any messages that violate any of the following guidelines: 1. Explicit references to alleged illegal or unlawful acts. 2. Graphic sexual descriptions. 3. Racial or ethnic slurs. 4. Use of edgy language (including masked profanity). 5. Direct personal attacks, flames, fights, trolling, baiting, name-calling, general nuisance, excessive player criticism or anything along those lines. 6. Posting spam. 7. Each person may have only one user account. It is fine to be critical here - that's what this board is for. But let's not beat a subject or a player to death, please. |


text:
Had a great stay in the autumn. Far away from traffic, people, shops and noise. The perfect getaway for a weekend. Nice food and helpfull serviceminded people. There was no wifi and a poor tv signal, but for our stay it only helped in the feeling of getting away from everything.
Denmark >
Jutland >
North Jutland >
Laesoe Island
Number of rooms: 12
- Also Known As:
- Laerkely Hotel Denmark/Laesoe Island


text:
Emma appeared on the Tonight Show with Jay Leno on October 24th to promote American Horror Story: Coven! She shared some past Halloween costumes and showed off her costume for this year! She got to interact with some wild animals! She even shared a photo via Instagram holding an otter! Below have over 400 captures, stills and videos from the show…
Below are captures from last nights American Horror Story: Coven entitled The Replacements! All I can say is this can't be the end!!! Emma was spotted out and about in West Hollywood on Wednesday (October 23rd) and today (October 24th) grabbing coffee in LA. Check out the photos below!
Emma shared a new Tyler Shields' photo via Instagram, which is featured in his book "Dirty Side of Glamour". She also shared a cute childhood photo of her and little sister! Also added a still from tonight's new episode entitled The Replacements, check back tomorrow for captures. Below can watch a featurette that goes inside the house used for Miss Robichaux's Academy!
Misc. >> Official Twitter/Instagram Photos
Check out captures of Emma in Boy Parts episode from American Horror Story: Coven last night! Check out captures and preview from next weeks episode entitled The Replacements!


text:
2014 is a Municipal Election year. Election Day is Monday, October 27, 2014.
The Nomination period for Mayor, Deputy Mayor and Councillors opened on January 2, 2014, and will close at 2 pm on September 12, 2014. To learn more about the elections visit 2014 Municipal Elections
Individual biographies and photos of the current Tecumseh Council Members have been removed from the Town's website during the election period, in the interest of fairness for all candidates.
Gary McNamara, Mayor |


text:
shrek 1 free movieI Discovered a DVD part Three p 4As I webcam down from my agonorgasmos, Pete was kneeling with his dick poised to go into me and it solely took one quick thrust to go right to the hilt of my sopping aperture. I looked across to watch Jane sitting in chair with her knees by her ears and Three fingers squelching in her slit watching as Pete pounded my vagina.
I was about to cum afresh when I asked Pete to fetch out. 'I desire u to cum hands-free, like I saw in the movie. Pictures and movie scenes by requestHi to anyone who's reading this, firstly I'd just like to say thanks to anyone who visits my profile and for all the great comments and and messages, I have a fun making the pictures and movie scenes on my profile just as much as u have a fun watching 'em.
In any case now to the point, as of next weekend I'm gonna be home for Two months over the Christmas break which means alot of access to my s****rs pants and underware. Turning Tia out p 5Unable to focus on my market research any longer, I locked my computer and went home. A modest studio apartment within walking distance of a bus stop from downtown, I opened my door and just now peeled off my jacket, boots, and slacks. Feeling free and inhibited, I walked over to my desk and turned on my laptop, then proceeded to sit down in my rather comfy beige rolling chair.
One time my internet connection was recognized, I typed in a free porn web page into the browser and began searching for movies. Tied To Please p 2It was smth this babe had developed over time by herself. This babe would tie herself and then struggle to receive free. The resulting climax was even more good than this babe had achieved with her former paramours, out of the problems of pleasuring their raunchy hang-ups.
But with any dream, there's always a risk. The risk that somebody will check out her secret wants and embarrass her. The risk that this babe could be hurt by her partner. Brainwashed p 9The look of mindless fun on his face was indescribable. Paula was clearly addicted to jerking off to homosexual porn, and Gareth knew that, were a real dick present, Paula would submit as eagerly as the tiny guys in the movie. The question was, was Paula always homosexual? Or had this guy come here just as defiant as Samuel? Did this movie actually break guys as that tranny had claimed?
Gareth's attention was then drawn to Samuel, who was likewise groaning in orgasmic release! s****r in law and the Tanning Daybed A Story of Blac p 11"Oh no we aren't done yet" I told standing sliding my panties down and lastly letting my aching dick spring free right into her face. I was a nice 6.5" (not a huge but make no doubt of me it receives the job done)
Still on her knees this babe shrank away from my dick like it was a live snake. Forgetting to cover herself and letting her breasts swing free afresh as this babe overspread her eyes with her hands, real tears were coming without her eyes now. My Fetish For Pants Ch6 p 4So Kimmy got back here friday afternoon and so my experience starts!! Now just to let u know, we set some ground rules, this babe won't receive nude, nor am I allowed to touch her and sex is definatly out, and we do it solely one night a week unless this babe desires to do greater amount, and although this babe's a relativly shy gal, feels this babe could do it for some free rent! I've sent her movie scenes and stories of what turns me on so this babe has an idea of what to do!
Oh That Inc*st Part Two Mom Receives Frisky p 7"Uh... sure Mommy. Uh... I'm sorry too. Next time I'll close the door."
"Don't worry about it. It's our home and we should be able to feel free," Sue told. "U're just a 'lascivious teenager' in any case, right?" Sue laughed. Tommy had to smile at the Iterate of his words. This guy laughed too. Then this babe added, "U did clean up the floor didn't u?" "Mommmmm!!!" Tommy told and his face turned bright red. Satisfying Guys Dicks Cum and Throats (Blindfolde p 9The freaking Sistine Chapel of Goo is what that video is. This guy knows it nearly by heart that's how often this guy's watched it, that's how often this guy's eaten his own load to it. It opens with a woman's voice saying 'I wanna kiss my spouse, with your cum still in my throat". Then it starts. This guy hears the voice say it. She's playing the fucking movie! This babe discovered it, and this babe's playing it.
Recorded Scenes - Photographs, Shared Having photographs taken of u, either nude or indulging in a raunchy action, to be shared with others. Yep Recorded Scenes - Movie, Intimate Having movie taken of u, either nude or indulging in a raunchy action, for intimate viewing solely. Yep Recorded Scenes - Movie, Shared Having movie taken of u, either nude or indulging in a raunchy action, to be shared with others. |


text:
Final Fantasy XV
How is Kefka beating Zack in today's poll?
- Back To:
- Board List
- Topic List
- Topic Archived
Sucks that Ryu came in third. I thought a character who's been around since the 80s and is the MC of arguably two of the best action games in the past decade (both of which were million+ sellers) would have done better. Oh well, people simply tend to gravitate toward RPG characters on this site. Noone cares about Ninja Gaiden games, on any site. Whatever real fans the series had disappeared during the ps1/ps2 era. I know a couple of them, they are 30+ years old with their own families and hate the new games. Also, Joker and Kefka are nothing alike, unless the only thing you know about them is that they have a clown-like appearance. Poor Zack, Cloud fans probably hate his guts. --- "Now go ahead and leap ignorantly to the defense of wealthy game companies who don't know or care about you." | |
Valcrist_Mk2 posted... TehAssasin posted...Anyway, I don't see why people need to care about these polls. I think Link is so popular because he's a successful self-insert character... Players want to play as heroes they can identify with, right? I mean, games are not only about seeing the story of the hero unfold; since games are interactive experiences we typically want to be able to see things from the hero's perspective of view (ergo, it's not enjoyable playing as a protagonist working towards goals you couldn't see yourself work towards in real life)... So, while games like Final Fatasy (and many, many other games) let you partake in the story of a fleshed out character, The Legend of Zelda games encourage you to cast yourself as Link's character. Sure, you don't have complete freedom in the games, but still; they let YOU be the hero who conquers evil and saves the princess. That's also why I imagine it's so important that Link is not voiced (save for generic battle cries, grunts of strain and cries of pain). Super Mario 64 could've been the same as a Legend of Zelda title if they hadn't given Mario exclamations like "HOH! HOHOO! YAAHOOO!" when he jumped because Nintendo actually put enough characterization into those shouts to make you feel Mario's jolly adventurous personality through them... Not so with Link: Even with the voiced sounds he makes he's still enough of a blank character for you to be able to insert your own personality into the games... This is, of course, just my guess as to why Link is so popular, but I don't think I am entirely wrong. --- Nurture your minds with great thoughts, to believe in the heroic makes heroes. - Benjamin Disraeli | |
I get the point, Chap. But I still vastly disagree Link has any place in a contest with characters like Snake or Big Boss. --- http://www.youtube.com/watch?feature=player_embedded&v=2CmNMx52Z_k And then he kicked the bucket by overdosing. | |
Bellum_Sacrum posted... Cinerary posted...Sucks that Ryu came in third. I thought a character who's been around since the 80s and is the MC of arguably two of the best action games in the past decade (both of which were million+ sellers) would have done better. Oh well, people simply tend to gravitate toward RPG characters on this site. You think that no one cares about it on any site because of a few people you know? Obviously you weren't around any of the NG boards here on GFAQs. The "real" fans started disappearing when NG3 came out last year - many before that when Tomonobu Itagki left Team Ninja. Most certainly not during the PS1/2 era. --- PSN: SouthPhillySanta http://i.imgur.com/X6ju8.png http://i.imgur.com/CKORN0d.jpg Yo homie...is that my briefcase? | |
TG_Wolf posted... kratoscar2008 posted...zack is a Cloud wannabe. Zack isn't the reason why Cloud exists. Zack is only one part of the reason why Cloud acts they way he does for a majority of the game. --- New Modest Mouse album - 2014! Do you see what happens when you find a stranger in the ass?! | |
I like Kefka more than Zack plain and simple. He's cool and all but I didn't like Crisis Core... or any of the VII compilations. How do you f*** up a back story with all the info that VII already gave us? I mean seriously??? But anyway my opinion but I liked VI>VII>Crisis Core (same thing goes for their protagonists) --- FF: IX=T>VI>V>XII>IV>T-0>VII>TA>III>XI>IVTAY>TA2>VIII>I>X=II>XIII>XIII-2>XIV>X-2 Lost Odyssey>FFXIII |
- Back To:
- Board List
- Topic List
- Topic Archived


text: Trevor's team View full-size image < previous next > Is this photo a winner? "My Brother Trevor is with one of his buddy's . checking up on Trevor and getting his shirt .Trevor needs a kidney which he is on the the list we r just waiting for a call .i have had a great experience with custom ink we love the shirts." - Trevor's team (Oct 15, 2013) Share this photo on: Twitter Facebook Pinterest Similar Photos: showing support to Trevor | charity | participant teams | brother | small group Feeling inspired? Visit the CustomInk Design Lab to start your own group order. Design Your Own comment by Guest - Oct 15, 2013 - back to the top Go Trevor comment by Guest - Oct 15, 2013 - back to the top Trevor is my grandson, very pound of him he has been through so much just waiting on the call for the transplant comment by Guest - Oct 17, 2013 - back to the top Praying for you Trevor good luck


text:
Highly annoying
screen Bezel cracking?
Posted 22 October 2012 - 12:36 PM
Highly annoying
Posted 22 October 2012 - 12:55 PM
Edited by jikobutsu, 22 October 2012 - 12:55 PM.
Posted 22 October 2012 - 04:21 PM
Posted 22 October 2012 - 06:02 PM
Posted 22 October 2012 - 07:06 PM
Posted 22 October 2012 - 07:25 PM
Posted 22 October 2012 - 08:06 PM
Orange San Diego
Posted 22 October 2012 - 09:29 PM
Posted 23 October 2012 - 09:03 PM
Posted 23 October 2012 - 09:35 PM
In regards to spare parts, didn't a couple of people on this forum brick there phones? Wonder if they are for sale?
Posted 23 October 2012 - 10:56 PM
Nothing wrong here, excellent build quality really. Maybe a batch or two suffered poorer build than most?.
Agreed, the build qaulity is excellent, very solid build, no complaints at all apart from power and camera button being hard to press. Also, off topic, the proccessor is excellent to, fast and reliable as you would expect from Intel.
Posted 25 October 2012 - 05:04 PM
I'm not very happy about this, especially as spare parts are unavailable.
I have considered approaching xolo regarding spares, do you think it's worth a shot?
Posted 25 October 2012 - 05:17 PM
Are you in the UK? If so, Xolo, an Indian company, will just laugh at you. Even if you are in India the chances of them giving or selling parts are extremely doubtful. The best you'll get is an offer to repair it.I now have another crack on the other side near the hdmi out despite not dropping my phone.
I'm not very happy about this, especially as spare parts are unavailable.
I have considered approaching xolo regarding spares, do you think it's worth a shot?
Matthew 23:12
Posted 05 January 2013 - 10:43 PM
Posted 06 January 2013 - 10:36 AM
Build quality seems hit and miss on this phone...
In regards to spare parts, didn't a couple of people on this forum brick there phones? Wonder if they are for sale?
Most of us got our phones repaired. Have a look on ebay though as I've seen several broken San Diego phones on there. Before Christmas there was a chap selling 7 broken phones together.
Posted 10 February 2013 - 09:08 AM
Posted 14 February 2013 - 11:42 AM
The phone is less than 2 months old, and has hardly been used as I'm waiting for the opportunity to unlock it to use with a Talkmobile SIM. I'm disappointed - it's a powerful phone, wrapped up in an iffy body.
At least my over 2 year old Orange San Francisco is still going strong .. !
My feeling is that when/if it is repaired, I will sell it on. Shame, as it is in many respects an exceptional phone for the price.
Edited by alexquant, 14 February 2013 - 11:45 AM.
Posted 22 February 2013 - 01:23 PM
Posted 20 March 2013 - 11:55 PM
I just went around my OSD and here is what I found, under very close inspection:
4 cracks in the black bezel, these go all the way from the top of the device to the silver band, one of this cracks has part of the bezel jutting out.
5 cracks in the silver band.
I have babied this device ever since I bought it and it was only out of a case for a week (while I was waiting for the case to arrive).
Posted 23 March 2013 - 08:37 PM
I think it is certainly down to one's attitude, and not "luck", when you approach this situation. If you storm into it with an attitude of entitlement and expectancy, people very quickly pick up on that, and if you are cold or abrasive in any way, surely they're going to be *less* inclined to want to side with you and help you? Makes perfect sense that I'd help someone who was charismatic, friendly and light hearted, over someone who was defensive and rude. I'm not saying any of you have been like this, I am stating that, in the past, I have, and since I have changed my general attitude to life massively in the last year, I can see how I used to be, as opposed to how I am now with people, and I get far more happy responses and genuine human laughter and banter than when I was cold, abrupt and terse.
Think about this: the call centre representative is employed in a rather dull and demanding job, possibly in a country where their are extreme social hardships and a low quality of life. *ANYTHING* you can do to lighten their mood and lift their spirits, is a good thing primarily for them, foremost, as they have to listen to rude, aggressive Brits, day in, day out - can you imagine how that feels? I **always** start a phone call with: "Hello, how are you doing today - are you having a good day?"- I am not obliged to - it's not about that, I genuinely enjoy making other people happy, and even if I didn't get my fault resolved, the very minimum I have done is to be Christian towards them and make them feel valued, and I enjoy talking to people for its' own sake, so I ask them questions about their life, about their day and what they will be doing this evening, etc etc
Just remember - they work in a boring job, and if you are rude or expectant, they will be pretty certain that, whatever they do for you, you'll possibly still be rude afterwards, so there's no emotional reward for them (don't we all want to be made to feel special? We deserve it!)
Just my input, a little honey goes a long way, and catches way more flies than vinegar (not that they are "flies" )
Edited by glossywhite, 23 March 2013 - 08:40 PM.
0 user(s) are reading this topic
0 members, 0 guests, 0 anonymous users


text:
SAML 2.0 leaves the deployer a lot of options, like how to pass attributes, what binding to use, how to use PKI, what should be signed and what should be encrypted.
An unwanted effect of all these choices is that two deployments of software supporting SAML 2.0 may not work as smooth together as expected.
This profiles defines a minimum set of bindings and rules that needs to be followed, for those entities that are requested to follow this profile.
The Interoperable SAML 2.0 Profile is a SAML 2.0 WebSSO Deployment Profile.
July 6th 2009
Site went live.


text:
Here's one of our local scumbags that is endangering a 16 month old baby. He's got a record and is definitely a bad guy. I think the apartment is his cousins and the child is his nephew. Sacto 9-1-1: Deputies see, hear boy held hostage in Arden Way standoff
Join FirearmsTalk.com Today - It's Free!
Are you a firearms enthusiast? Then we hope you will join the community. You will gain access to post, create threads, private message, upload images, join groups and more. Firearms Talk is owned and operated by fellow firearms enthusiasts. We strive to offer a non-commercial community to learn and share information.
Join FirearmsTalk.com Today! - Click Here
Man,,,what a head case...A child??!!?!!??
The tree of liberty must be refreshed from time to time with the blood of patriots and tyrants. Thomas Jefferson
It's shame you can't be put on death row for holding a child hostage.
Not Registered? Register now! - It's free and helps the community grow.
The standoff continues, here's an update:Sheriff Says 'Time Is Not Our Enemy' In Standoff - cbs13.com
Burn him at the stake and then shoot him.
"This is my rifle, this is my gun." "This is for fighting, this is for fun." -Full Metal Jacket "I joined the Navy to drink in foreign countries and fornicate." -unknown
CA, isn't that just off Arden Way? Holding an infant hostage makes you an effing douche!! Bows to Tango!
People get the government they deserve.
Yes it is Dune. It just ended, they got a shot in and wounded the azzhole. The child is unharmed.
Dam only wounded him, the cost is now more than he's worth. Too bad he wasn't put down for good before he is painted as confuses/distressed or what ever other label they will give him to help rehab this azzhat. Simply not good money management by the local goverment. Already paid for the sniper training for the PD and ammo is reasonably priced. A head shot would have save thousands of dollars.
Those who hammer their guns into plows will plow for those who do not." ~ Thomas Jefferson


text:
- Shopping Bag ( 0 items )
From the Publisher
"In her harrowing memoir, Kilgore recounts the story of abuse at her older sister's hands. Tortured physically and mentally for years, Kilgore was forced to verbally degrade herself before entering her own bedroom and threatened with death if she told. This book deals with the mostly unknown phenomenon of sibling abuse. Kilgore not only shares her own tale, she also tells the stories of others like herself who have lived in fear and shame for years."—Rosemary Smith, NetGalley
"This book breaks new ground in exposing the author's terrible experiences, how her home was turned into a prison, and the lasting effects of bullying and sibling abuse. The result is a powerful testimonial highly recommended for any health collection strong in family interactions."
—California Book Watch


text:
First off, I finally finished editing one of the livestream videos! You can watch Winter Wrap Up Twilight being made(in fast motion) here: www.youtube.com/watch?v=wYWHxu…
Now, a giant Pinkie update!
Some people had suggested that I use foam in Pinkie for various reason, and I decided it would be worth a try. Here are my thoughts and results!
I used upholstery foam(or foam cushioning as some might know it) because it's thick, regains its shape even if it's crushed, and it's available at Wal Mart in large quantities ahah.
First off it was more expensive than I expected, but still not horrendously expensive. I bought a 48"x72" piece for $65. This is enough for one and a half ponie. Second, I really underestimated its weight. This stuff is HEAVY. I was hoping to reduce Pinkie's weight by using this foam, but that didn't happen.
Fitting it in the plush:
I measured and cut large strips of the foam and rolled them up so they would fit through the body. I didn't roll them super tight, but still tight enough that they weren't easily crushed and I tied them with ribbon (that was coincidentally pink lol). Then I unstuffed Pinkie, leaving a layer of stuffing at the bottom of each hooves so the foam wasn't sitting directly on the fabric.
Was already a nightmare at this large scale, and adding the foam cores made it even harder. I usually let the stuffing pack itself down, but that was impossible with the foam in the way, so a lot of time and extra stuffing was spent smoothing her out. In the end, the foam didn't help her weight. I actually think she's a little heavier than before. I also didn't save on stuffing as much as I expected. I ended up saving about 2-3lbs but that's it. I was hoping on cutting out at least 5. However, the foam makes her a pretty freakin solid plush. She now stands like a rock and may have a chance at being able to stand once the head goes on now. Although she's solid, the foam is still flexible enough so she's still a very cuddly plush. I also think I can just use a roll of foam instead of a pvc pipe in her neck like I was thinking about yesterday. Or if I do end up going with a pipe, it's going to rest on the foam roll inside her body so it won't cause damage to her over time.
So overall, I think the foam is going to be a default part of any large plushies I make in the future. It's a little more costly and heavier than I wish, but the stability and durability it adds to the plush is definitely worth it.
edit: SHE STANDS!! YESSSSSS! I just test-pinned her head in place with the rolled up foam in her neck and she stands! Like a boss xDD


text:
Sometimes Love
Marion Brechin - 04/05/2014
Easy dance to pick up and it Flows well....Love the Music by Helene Fischer. Will be giving this to my Beginner's and Intermediate Classes.
JEAN Fallows - 15/10/2012
Easy teach and flows lovely with the music. easier alternative to Is tomorrow mine.
Karen Kennedy - 05/08/2012
Really pleased with the response to my dance Sometimes Love. There are now two video of the dance been done and thank you to all who have said they are going to teach it. You have the option to keep the turn simple or make it one and half turns but it is up to each dancer to do what they are comfortable with, Nice music which allows you to open up the dance and just enjoy it.


text:
Clinton and Chavez weigh in on Zelaya's stealth return to Honduras
(Read article summary)Correspondent
The United States and Venezuela weighed on the escalating political drama in Honduras Monday. US Secretary of State Hillary Clinton called for dialogue between ousted President Manuel Zelaya and the de facto government, while Venezuelan President Hugo Chavez urged it to hand power back to Mr. Zelaya.
In a surprise turn of events Monday, Zelaya snuck across the border and took refuge in the Brazilian embassy, where, under international law, Honduran officials cannot arrest him. His return comes three months after he was forced out of the country at gunpoint by his political opponents.
Some observers fear violence between Zelaya's supporters and those loyal to the interim government, headed by Roberto Micheletti. Mr. Micheletti imposed an emergency curfew Monday and insisted all was calm.


text:
Well, I have been in Walldorf only twice. And last time I was really lucky to choose the L'Auberge hotel. The hotel in general - is just a building. But it always depends, where the building is built and who is the heart'n'soul of the building. So, for the first - L'Auberge is on the edge of Walldorf. This means... More
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Priceline and Odigeo so you can book your Hotel L'Auberge reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


text:
PHOENIX (AP) -- A March 2016 trial date has been set for a Phoenix man charged with fatally stabbing his 12-year-old half-brother.
Authorities say 27-year-old Andrew Ward killed Austin Tapia on March 12 and explained his motive by saying, "Honestly, I just felt like killing."
Prosecutors are seeking the death penalty.
Ward pleaded not guilty to a murder charge in Tapia's death.
While in a Maricopa County jail, Ward was charged with first-degree murder in the April 2 death of his cellmate.
Investigators say Ward used a golf pencil to stab 33-year-old Douglas Walker in the eyes, beat him and forced a plastic bag and peanut butter sandwich down Walker's throat.
Ward has pleaded not guilty in Walker's death.
No trial date has been set in that case.
Related stories:
Death penalty sought against man in boy's death
MCSO: Man accused of stabbing half-brother kills cellmate
Phoenix man pleads not guilty in fatal stabbing of half-brother
Man accused of stabbing 12-year-old brother to death said he 'just felt like killing'


text:
Audit shows Nevis School District is financially stable
Auditors presented the Nevis School Board with good news this week.
The school's unreserved, undesignated general fund balance has reached $956,017, up significantly from the $528,162 amount in 2006.
The amount has returned to totals seen in 2003, when the fund balance totaled $974,067.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at email@example.com and we can help you.


text:
Product Details
The Husky 23 in. 3-Drawer Plastic Tool Box is constructed with high-impact polypropylene resins and features full-extension steel slides for convenient use. Its sturdy surface resists dents, rust and marring.
Product Title: Husky 23 In. 3-Drawer Plastic Tool Box--Discontinued Hp2331thdo Hp2331thdo
Manufacturer: Husky
Power Score: 4.9 | 35 Reviews


text:
The '90s Alternative Rock Vocal Hook Supercut Is Here
Nirvana, No Doubt, Weezer, Garbage, Blur, Beck, Alanis, Pavement, Third Eye Blind, and more
The '90s was famously a time for angsty, throaty vocals often laconically growled out ironically candied to sound something like pop. It was also a period with a whole lot of "doot-doot-doos, whoa-ohs, na-na-nas, and ooh-oohs" as CBC Music words it in the description for the clip above. The Canadian broadcaster's "'90s Alt-Rock Vocal Hook Supercut" compiles the repetitive, often wordless choral yelpings of nearly 40 of the biggest acts of the era (along with snippets of their respective music videos), and it's amazing. You'll find our 10 personal favorites below. After you're done, check out our list, "Blame Nirvana: The 40 Weirdest Post-Nevermind Major Label Albums." Via Rolling Stone.
- Beck, "The New Pollution"
- Garbage, "Queer"
- Third Eye Blind, "Semi-Charmed Life"
- Pavement, "Cut Your Hair"
- Weezer, "Undone — The Sweater Song"
- Alanis Morissette, "You Oughta Know"
- Nirvana, "Lithium"
- Blur, "Girls & Boys"
- Counting Crows, "A Long December"
- No Doubt, "Don't Speak"


text:
What does WCBA mean in Canadian?
This page is about the meanings of the acronym/abbreviation/shorthand WCBA in the Regional field in general and in the Canadian terminology in particular.
Find a translation for WCBA in other languages:
Select another language:
Discuss this WCBA abbreviation with the community:
Use the citation below to add this abbreviation to your bibliography:
"WCBA." Abbreviations.com. STANDS4 LLC, 2015. Web. 1 Mar. 2015. <http://www.abbreviations.com/term/228191>.
WCBA also stands for:
- Wake County Bar Association
- Wake County Basketball Association
- Warrington College of Business Administration
- Washington County Bar Association
- Washington County Builders Association
... and 20 more »
Nearby & related abbreviations:
Alternative search:
- Search Workers Compensation Board of Alberta on Amazon
- Search Workers Compensation Board of Alberta on Google


text:
Casket Flowers
- The passing of a loved one is a difficult time. Ordering flowers for the service is a very personal time. Our designers at Buckets Fresh Flowers and Florist are compassionate to the wants of the family. We can arrange either a private consultation at the store or your home. We will discuss all aspects of choosing the perfect flowers to remember your loved one.
- Choosing your florist directly is a very personal matter, we understand that you need to be comfortable with the flowers you choose and that we will be able to provide the service you deserve.
- Flowers are our business and we strive to have the freshness and most beautiful flowers for the memorial.
- Choosing a casket spray is a very personnal discision. Please look at our selection of casket sprays and call or visit the store to have a personnal consultation time to discuss what you need for the service. Buckets Fresh Flower Market and Florist is fully qualified to design a beautiful memorial to your loved one. We pride ourselves in outstanding service and quality flowers.


text:
Updated: 03/08/2014 11:16 PM
Created: 03/08/2014 9:18 PM WHEC.com
Celebrating a decade of disco, afros and lava lamps all while raising money for a good cause.
The 11th annual Ugly Disco took place Saturday at the Rochester Riverside Convention Center. The disco features live music and pictures with football players from the Buffalo Bills. All proceeds from Saturday's event will go to Golisano Children's Hospital.
News10NBC/WHEC-TV welcomes your opinion and interaction on our website, but please remember to keep it clean. If you're advertising for another business, being profane, vulgar or slanderous your post will be deleted. By commenting on this website, you agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Use. Comments are not pre-screened before they posted.


text:
This page contains Sim Ant Hints for Super Nintendo called "Start digging after getting approximately fifty ants" and has been posted or updated on Sep 7, 2006 by Kayrii. Let us know what you think of this Hint by thumbs voting.
- Developer: Tomcat System
- Publisher: Maxis
- Genre: Strategy Breeding/Constructing
- Release Date: Not Set
- ESRB: Not Set
Start digging after getting approximately fifty ants
Once everything is dug out at the bottom of the screen, a hole will appear. The red ant nest is through the hole. This route is useful when stealing food and larva. Red ant larva will turn into black larva after brought back to your nest. Note: Other ants cannot be brought through the hole to take larger amounts of food.
The hole may also be used when a level is started to quickly kill the red queen. This is particularly effective when there are over 200 red ants, but less than 10 black ants present.
Back to all Cheats
Stuck on this game? Set a specific, clearly defined question and let others answer your question or view answers to previously asked questions. If you think you are an Sim Ant expert then please try to help others with their questions.
Chibi Maruko-Chan: Mezase! Minami No Island!! - Gameplay Video
- Nov 13, 2014, Views: 44
Logos Panic: Goaisatu - (OPENING - GAMEPLAY)
- Aug 3, 2014, Views: 118
The Hunt For Red October - Gameplay Video 1
- Aug 3, 2014, Views: 89
Donald Duck No Mahou No Boushi - Gameplay video 2
- Aug 3, 2014, Views: 102
- Chibi Maruko-Chan: Mezase! Minami No Island!!, (SNES)
- Might And Magic 3: Isles Of Terra, (SNES)
- Logos Panic: Goaisatu, (SNES)
- Hana No Keiji, (SNES)
- Battle Cross, (SNES)
- Demolition Man, (SNES)
- Harley's Humongous Adventure, (SNES)
- Archer McLean's Super Dropzone, (SNES)
- RoboCop Versus The Terminator, (SNES)
- Dream Basketball: Dunk And Hoop, (SNES)
- Gradius 3 - Level 1 Gameplay, Normal Difficulty, (SNES)
- Super Mario World - Gameplay, (SNES)
- 7th Saga - The TAS Speed-Run, (SNES)
- Donkey Kong Country - Gameplay, (SNES)
- Super James Pond - Gameplay Video 1, (SNES)
- Street Fighter 2: The World Warrior - Review Trailer, (SNES)
- The Lawnmower Man - Gameplay Video 1, (SNES)
- Mighty Morphin Power Rangers: The Fighting Edition - Gameplay Video 1, (SNES)
- Tuff E Nuff - Dead Dance (INTRO - GAMEPLAY - SUPER FAMICOM - 1993), (SNES)
- Total Carnage - Gameplay Video 1, (SNES)
- Tom And Jerry - Gameplay Video 3, (SNES)
- TMNT 4 - Gameplay Video 18, (SNES)
- Tiny Toon Wacky Sports Challenge - Gameplay Video 1, (SNES)
- Tinstar - Gameplay Video 1, (SNES)
- Thunder Spirits - Gameplay Video 1, (SNES)
- Tetris 2 - Gameplay Video 1, (SNES)


text:
International Lingerie Model Of The Year
The search is on for our next Miranda Kerr!
Australia's leading venue entertainment promoters; Pacific Enterprises have created the most sizzling model search this country has ever seen! Australian supermodel Miranda Kerr has built a high profile world-wide in her role as an extremely popular Victoria's Secret runway and catalogue model. Miranda has capitalized on her success with Victoria's Secret as she has now launched her organic skincare range "KORA by Miranda Kerr". Now, we're searching for another talented and attractive lingerie model to follow in her footsteps. Check out Miranda's super hot TV ad here>>>
We are definitely "bringing sexy back" as we look for the nation's hottest undercover models and the prizes are amazing! Our International Lingerie Model Of The Year wins a trip to the LAS VEGAS INTERNATIONAL LINGERIE SHOW where she will be featured in the Official Runway Presentation and will have the opportunity to meet and impress industry heavy weights! The preliminary competition is being held in premier entertainment venues all over the country between January and the end of August.
Lingerie Model Finalists to stay in luxury at the Moroccan Resort in Surfers Paradise!Some of the world's hottest up-and-coming lingerie models will be staying in style and luxury when the spend their fun filled week on the Gold Coast for the International Lingerie Model Search Finals! Following their successful hosting of our stunning 2014 Australian Swimsuit Calendar Models earlier in the year, the generous folks at The Moroccan Resort in Surfers Paradise have again invited us to bring a bevy of beauties to spend some time at their spectacular resort! The Swimsuit Calendar gals had an amazing stay at the resort and we could not be any happier! They say location is everything and it doesn't really come much better than this! The Moroccan is situated smack bang in the centre of Surfers Paradise and is located directly opposite the beach! It's an easy walk to famous Cavill Avenue for great shopping, cafes, restaurants, bars and nightclubs. And Pacific Fair shopping centre is only a tram ride away uising the Giold Coast's brand new light rail system! The International Lingerie Finalists can put the finishing touches to their already impressive physiques and work up a sweat in the fully equipped gym followed by some laps in the heated lap pool. After a massive cardio workout, the finalists can also take advantage of the resort's sauna and spa and just spend some time relaxing! The Moroccan resort offers a choice of accommodation including well appointed one and two bedroom holiday apartments, many boasting ocean, hinterland or canal views. which include full kitchen and laundry facilities and balconies with Gold Coast skyline, hinterland or ocean views. Or drop in at the Breakfree Moroccan Resort Facebook page here>>> Exclusive Underwear comes onboard!We are absolutely delighted to announce the birth of a brand new partnership! The International Lingerie Model Search have teamed up with Exclusive Underwear and this means that our winners are going to receive some amazing and sexy lingerie as part of their prize packs!
Visit and LIKE their Facebook page here>>> 2013 ILMS Winner Casey on the runway in Las Vegas!Here is our 2013 International Lingerie Model Search winner Casey Parsons in one of her outings on the runway at the International Lingerie Show in Las Vegas! Casey Parsons crowned International Lingerie Model Of The Year!It was almost a case of history repeating itself when yet another Casey won the International Lingerie Model Final as our first ever winner was in fact named Casey as well - Casey Newport actually. But this time it was Brisbane model Casey Parsons who dazzled the judges at the 2013 International Lingerie Model Search Final and beat a bevy of beauties for the coveted title of International Lingerie Model Of The Year! A relative newcomer to the competition scene, it was actually one of Casey's first ever comps and definitely her first International Final! Following her win, a stunned Casey commented "I never in a million years would have imagined that I'd be in the top three - let alone win!! The 2013 ILMS Final made hstory as for the first time, we had the pleasure of hosting a finalist all the way from Hungary! The judging panel including Kristy O'Sullivan from Fashion TV Australia, Duncan Bruce from Harlem Productions, Mark Seeman from RedhotPie and Rob Tamburro from Bodyograophy had a very hard time separating the amazing ladies on stage but after appearing first in their singlet and jeans, next in club wear and finally in the all important lingerie section complete with confetti bombs, the top three emerged on the score sheets. Second runner-up was Avril Mathie while the young lady who had travelled the farthest - Maria Simon from Hungary was announced 1st runner-up! The sensational ILMS final hosted by LOVE Nightlife was the culmination of a fun filled and action packed week for the head turning finalists which included media functions, photo shoots, a ride on Gold Coast JetX Jet Boat, a mind bending visit to Infinity, fun times at TimeZone Surfers Paradise, ride in a Fire Truck courtesy of Fire4Hire and a visit to Currumbin Wildlife Sanctuary where our overseas finalists joined our Aussie girls getting up close and personal with the native wild life! |


text:
Windstream Announces Workforce Reduction
LITTLE ROCK, Ark., Feb. 21, 2014 (GLOBE NEWSWIRE) -- Windstream (Nasdaq:WIN) is reducing its workforce to increase operational efficiency as it continues to focus on becoming the premier enterprise communications and services provider.
The company plans to eliminate approximately 400 positions by March 3. About 175 of those positions are being eliminated through a voluntary separation initiative. Windstream currently has approximately 13,500 employees.
"Changes that affect people are never easy, but they are necessary for Windstream to succeed in a highly competitive marketplace," said Jeff Gardner, president and chief executive officer of Windstream. "We continue to invest in our growth areas, primarily business services and consumer broadband, and at the same time we must maintain a disciplined approach to expense management."
The changes are expected to result in annualized savings of approximately $20 million. The company expects to incur a charge of $9 million to $10 million in the first quarter to pay severance benefits to affected employees. In addition to severance payments, the affected employees will receive outplacement counseling. About Windstream Windstream (Nasdaq:WIN), a FORTUNE 500 and S&P 500 company, is a leading provider of advanced network communications, including cloud computing and managed services, to businesses nationwide. The company also offers broadband, phone and digital TV services to consumers primarily in rural areas. For more information, visit www.windstream.com.CONTACT: Media Contact: David Avery, 501-748-5876 firstname.lastname@example.com Investor Contact: Mary Michaels, 501-748-7578 firstname.lastname@example.com
Check Out Our Best Services for Investors
Action Alerts PLUS
Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.
Product Features:
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
Quant Ratings
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
Product Features:
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
Stocks Under $10
David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.
Product Features:
- Model portfolio
- Stocks trading below $10
- Intraday trade alerts
Check Out Our Best Services for Investors
Dividend Stock Advisor
David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
Product Features:
- Diversified model portfolio of dividend stocks
- Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks
Every recommendation goes through 3 layers of intense scrutinyquantitative, fundamental and technical analysisto maximize profit potential and minimize risk.
Product Features:
- Model Portfolio
- Intra Day Trade alerts
- Access to Quant Ratings
Options Profits
Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
Product Features:
- Actionable options commentary and news
- Real-time trading community


text:
Congressional District #1
This district is comprised of 12 counties. Iowa's 1st congressional district, while similar to others in the state, has its own unique attributes. Demographically its population holds firm to blue collar roots, even as white collar employment rises. The district is often called the John Deere district and Deere and Company has operations in the biggest cities of the district, Davenport, Dubuque and Waterloo.
District #1 Video profile
District #1 Discussion
Congressional District #2
The second congressional district stretches from Linn County in the north to the Iowa/Missouri border in the South. The Mississippi River borders the east and Wayne County is the western-most reach of the district. As with many Iowa congressional districts, the 2nd is as diverse as its geographic spread --from 21st century agriculture to the older traditional farming of the Amish -- from urban culture to rural Mainstreet.
District #2 Video profile
District #2 Discussion
Congressional District #3
Iowa's 3rd Congressional District covers 12 counties located in the central part of the state. The district is mostly rural and agricultural, but contains the state's largest city as well. The terrain of the third varies from flat and open land in the north to hills and timber in the south to urban cityscape. The district is home to approximately 622,000 Iowans. 65 percent reside in Polk County. The county with the fewest residents is Monroe with some 7,725 residents.
District #3 Video profile
District #3 Discussion
Congressional District #4
This district is comprised of 28 counties. Geographically, it looks like a sideways stocking, with the toe encompassing Indianola and Winterset, the heel in north-central Iowa including Mason City and Estherville, and the ankle about two counties wide on the north eastern Iowa tier reaching to the Mississippi River.
District #4 Video profile
District #4 Discussion
Congressional District #5
As required by law Iowa's 5 congressional districts are close to equal in population. But after that, the similarities end.
The fifth stands out on a map by dint of its shear size. Stretching North to South from Minnesota to Missouri and extending eastward from the Missouri river across nearly a third of the state, the 5th is the Iowa's largest congressional district and may well be its most complex.
It holds two cities, Council Bluffs and Sioux City of more than 50-thousand people. But apart from those urban centers, the population is in mostly rural communities like Orange City and Leon. The district covers 32 counties in all.
District #5 Video profile
District #5 Discussion
District #5 Web Exclusive
blog comments powered by DisqusComment Policy
Iowa Public Television encourages conversation and debate around issues, events and ideas related to program topics.
- The editorial staff of Iowa Public Television reserves the right to take down comments it deems inappropriate.
- Profanity, personal attacks, off-topic posts, advertisements and spam will not be tolerated.
Find out more about IPTV.org's privacy policy and terms of use.


text:
Le Chamois - Maison Argoat 3
from £76 /night help
Availability Your dates are available
Apartment | 4 bedrooms | sleeps 8
Key Info |
Le Chamois, Maison de L' Argoat 3 - (maximum 8 people)
Ideally located 300 metres from the Brevent cabine and a few minutes walk to the Aguille de Midi and the centre of Chamonix.
Le Chamois apartment is on the second floor of the chalet and provides a very spacious 80m2 of living accommodation, with absolutely stunning views from the lounge to Mont Blanc and the Aguille du Midi.
Decorated to a very high standard the apartment has four bedrooms: one double and one twin, and 2 single rooms, all are fitted with cupboards so there's plenty of space for clothing. Both the twin and single rooms have beds that transform into bunk beds if wanted. There is a shower room and second separate bathroom as well.
The living/dining/kitchen area is spacious, open planned and boasts high, wood clad ceilings. There is a fully fitted Italian kitchen that has all the modern appliances you would expect including washing machine, dishwasher and microwave, toaster, kettle and coffee machine.
The dining area is for eight people and the lounge area comprises two stylish comfortable sofas, a couple of armchairs as well as a coffee table and buffet.
Additional equipment has also been provided for your convenience, FREE WIFI, flat screen TV, DVD, CD.
Size | Sleeps up to 8, 4 bedrooms |
Will consider | Long term lets (over 1 month) |
Access | Car not necessary |
Nearest travel links | Nearest airport: Geneva 70 km, Nearest railway: Chamonix |
Family friendly | Great for children of all ages, Suitable for people with restricted mobility |
Notes | No pets allowed, No smoking at this property |
Features and Facilities
Luxuries | DVD player |
General | Central heating, TV, CD player, Wi-Fi available |
Standard | Kettle, Toaster, Iron, Hair dryer |
Utilities | Dishwasher, Cooker, Microwave, Fridge, Freezer, Washing machine |
Rooms | 4 bedrooms, 2 bathrooms of which 1 Family bathrooms and 1 Shower rooms |
Furniture | Single beds (7), Double beds (1), Cots (1), Dining seats for 8, Lounge seats for 8 |
Other | Linen provided, Towels provided, High chair |
Outdoors | Shared garden, BBQ |
Access | Secure parking |
About this location
The Rhône-Alpes region
Chamonix is in the Haute Savoie region of France facing the Mont Blanc chain and has some of the best off - piste skiing in Europe!
Only one hour from Geneva International airport, with shuttles from Geneva airport, a train station and an efficient bus system Chamonix is a holiday destination where you don't need a car, but the property does, however, have parking for 3 cars.
The Mont Blanc massif dominates the town and, winter or summer, you have the privilege of enjoying the most beautiful scenery in Europe. Many people think that Chamonix has the most spectacular scenery that skiers will see anywhere in the world.
Chamonix isn't just a ski resort or an outdoor activity centre; it is a thriving town in its own right; with 12,000 permanent residents which welcomes visitors all year round. Although Chamonix is famed as the extreme sports capital of the world but you don't have to be a world class skier or climber to enjoy it. The non-skier is well catered for also with golf, mountain-biking, husky drives, skating, para-gliding to name but a few. There are also wonderful walks with spectacular scenery. Italy is just 30 minutes away through the Mont Blanc Tunnel.
Chamonix is one of the liveliest après-ski resorts in the Alps. It is packed with bars and restaurants of every sort and even has its own micro-brewery. From a quick pizza to a gourmet meal at Michelin starred restaurants, there's something for every taste.
Live music starts around 4pm in several venues most days in the winter, and only a little less frequently in the summer. Even the most dedicated partier will struggle to get round the 14 bars, 80 restaurants, 100 shops and 7 discotheques in the average stay of a week.
There is a museum and art gallery, a cinema and a casino. In addition there is a large sports complex with a sports hall, indoor and outdoor ice rink, speed skating rink, 19 tennis courts (quick and clay) including 4 indoor courts, squash courts, swimming-pool complex with water-slide & fitness centre (saunas, Turkish baths, solarium). Chamonix is the only alpine town able to offer such a wide selection of entertainment.
Chamonix Town Centre
Chamonix is undoubtedly one of the World's top five ski resorts and includes four ski areas, Les Grands Montets, Le Brévent, La Flégère and La Domaine de Balme, there are 50 lifts serving 168km of piste. Chamonix also has the largest and most widely available amount of off piste skiing in Europe, including the most famous perhaps being the Vallée Blanche, one of the greatest experiences of a lifetime for an intermediate or above skier.
The Chamonix ski areas are easily accessible using the bus network and offer a vast range of beginner and intermediate skiing, as well as limitless off-piste skiing for the expert. If you don't want to take the bus, we will take you to the slopes in the morning and collect you in the afternoon.
In addition there are about a dozen resorts within an hour's drive, which means that you can always go where the snow and or weather is best. These resorts include St Gervais, les Contamines, les Houches, Mégève and Flaine in France; Courmayeur and La Thuile in Italy and Verbier in Switzerland.
There are more visitors to Chamonix in the summer than the winter; drawn by the beauty of the mountains and the wide range of activities available.
Of course, it's a mecca for climbers but there are also many marked paths for long or short walks along the high routes through the mountains.
Some of the other activities also include; Mountain biking along controlled trails Paragliding , Rafting, Canyoning , Swimming (lakes, indoor and outdoor pools) Windsurfing, Fishing, Horse Riding and Golf, Adventure Parks, Via Ferrata, Children's playground (with the Aquajet!) and s great Summer Luge
About the owner
Guest reviewsPowered by TripAdvisor
Guest reviews no reviews
Guest reviews Powered by TripAdvisor
Help other travellers decide where to stay
This holiday home hasn't got any reviews yet. The average rating on Holiday Lettings is four out of five. This place could be newly added or perhaps it's a well kept secret. Either way, it's time to reveal all.
This advert is created and maintained by the advertiser; we can only publish adverts in good faith as we don't own, manage or inspect any of the properties. We advise you to familiarise yourself with our terms of use.
You're booking with
Sophie M.
100% Response rate
Calendar last updated:02 Mar 2015
Based in Switzerland
- English
- French
- Spanish
- Italian


text:
DARKSIDE by DARKSIDE - over 1 year ago
"This is the Darkside Convoy Escort Team in Afghanistan. My team has one of the most dangerous missions here and have come together like a family. We finally had a day to rest so it was a good tim..." view full details
My cousin, the hero by Sam B. - almost 2 years ago
"About a week ago I received the tshirts that I had ordered for my cousins party before deployment. Everyone loved them and they were a hit!! Yesterday was the official deployment send off. I hug..." view full details
We Love Our Sergeant!!! by Sam B. - almost 2 years ago
"This is my 3rd time ordering from CustomInk. I have had a great experience every time I have ordered. Everyone is so helpful. This time the shirts I ordered were extra special. We designed a shirt ..." view full details
OEF XIII- 864th EN BN HHC Regulators by HHC Regulators - almost 2 years ago
"There are a lot of experiences when you're deployed, some good and some bad. One of our greatest experiences so far has been showing off our Company pride with our Regulator tee shirts ordered from..." view full details
432nd BSD by 432nd BSD - almost 2 years ago
"We are the 432nd BSD, Soldiers currently deployed in Afghanistan. The Hoodies your company designed and printed for us our the Detachement's first Organizational product. We were so excited when..." view full details
1st PLT D co. 1-501st IN BN (ABN) 4-25 by Joe - almost 2 years ago
"Soldiers returned from Afghanistan, OEF 2011-2012. " view full details
472d SIG CO in Afghanistan by DAWGS - almost 2 years ago
"We ordered our company t-shirts and hoodies through custom ink. Even from across the world we experienced excellent customer service. It was very easy to customize our design and create the produ..." view full details
Supporting Our Soldier by SSG MORLOCK, US ARMY - almost 2 years ago
"I created a Red Friday tshirt for my son & I to wear each Friday till my husband comes home from Afghanistan. The shirt turned out great so I asked some family members.... & the order grew. Then ..." view full details
My daddy's home back by My daddy's home - about 2 years ago
"This is the back of the picture of the kids as they wait for daddy to get off the plane from Afghanistan! " view full details
SFC David Reid Sr. Welcome home daddy by My daddy's home - about 2 years ago
"For my husbands homecoming from Afghanistan I had these shirts printed up for the kids, I had them design the front with my husbands name and on the back it said my daddy's home. Everyone loved the..." view full details


text:
Biologics such as Enbrel (by Immunex, bought by Amgen (NASDAQ:AMGN)), Humira (by Knoll Pharmaceuticals, bought by Abbott (NYSE:ABT)) and Orencia (by Bristol Myers, (NYSE:BMY)) have revolutionized the treatment of many auto-immune diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, and ulcerative colitis. They are huge a commercial success, with sales of biologics in excess of $10 billion a year. However, they are very expensive, costing $15,000 - $20,000 a year per patient, and have to be injected. Consequently, they are second line drugs, used only when the first line drugs such as methotrexate do not work. An oral drug would have the advantage of cost and ease of convenience. It could also challenge methotrexate as a first line agent. One such oral drug is Pfizer's (NYSE:PFE) tofacitinib, a JAK inhibitor. In its NDA filing, Pfizer demonstrated its efficacy and safety in phase III studies: ORAL Standard (A3921064) and ORAL Step (A3921032).
ORAL Standard was a twelve-month study in patients with moderate-to-severe active rheumatoid arthritis who had an inadequate response to methotrexate. Subjects were randomized into four cohorts: tofacitinib 5 or 10 mg BID, adalimumab 40 mg subcutaneously every other week or placebo, each of which was added to stable background methotrexate. At the 5 and 10 mg BID doses tofacitinib showed statistically significant improvement compared to placebo in reducing signs and symptoms of RA, as measured by 20% improvement in the American College of Rheumatology scale (ACR20) at six months; in improving physical function, as measured by mean change in Health Assessment Questionnaire-Disability Index (HAQ DI) at three months; and in inducing remission as measured by Disease Activity Score 28 ESR (DAS28-4(NYSEARCA:ESR) <2.6 at six months.
ORAL Step was a six-month study in patients with moderate-to-severe active rheumatoid arthritis who had an inadequate response to a TNF inhibitor and were randomized to receive tofacitinib 5 or 10 mg BID or placebo, which were added to stable background methotrexate. At the 5 and 10 mg BID doses, tofacitinib showed statistically significant improvement compared to placebo in reducing signs and symptoms of RA, as measured by ACR20 response rates; in improving physical function, as measured by mean change in HAQ DI; and in inducing remission as measured by DAS28-4.
Tofacitinib has been evaluated in about 4,800 patients from five pivotal Phase 3 trials and two ongoing long-term extension studies. In May 2012, the Arthritis Advisory Committee recommended approval of tofacitinib by a vote of 8-2 for adult patients with moderately to severely active rheumatoid arthritis. The FDA has provided an anticipated Prescription Drug User Fee Act (PDUFA) action date in August 2012.
In two successive issues of the New England Journal Of Medicine this and last week, three new studies have been outlined that make tofacitinib even more attractive.
In the first study, tofacitinib was compared to placebo as a first line agent in patients with RA on no background methotrexate.
In this phase III six-month study, 611 patients were randomized to tofacitinib 5 mg bid, 10 mg bid, placebo for 3 months followed by tofacitinib 5 mg bid, or placebo for 3 months followed by 10 mg of tofacitinib bid. The primary end points, assessed at month 3, were the percentage of patients with ACR 20 improvement, the change from baseline in HAQ-DI, and the percentage of patients with a DAS28.
Measure | 5 mg bid | 10 mg bid | Placebo | Power |
ACR20 | 59.8% | 65.7% | 26.7% | P<0.001 for both vs placebo |
DAS28 | 5.6% | 8.7% | 4.4% | P=0.62 and P=0.10 respectively |
There was a higher rate of adverse events and serious adverse events in the treated groups compared to placebo. Adverse events worth noting include infections, neutropenia, and elevation of elevation of lipids (LDL).
Pfizer has finally gone where no other company has gone by conducting a study without background methotrexate. However, Pfizer missed an opportunity - they should have directly gone against methotrexate by conducting a head to head study. They had little to lose - even methotrexate proved superior, tofacitinib would have become the next drug to try instead of a biologic. If tofacitinib proved superior, it could have supplanted methotrexate as the drug of first choice.
In the second study tofacitinib was compared head to head versus Adalimumab and Placebo in Rheumatoid Arthritis.
In this 12-month study, 717 patients who were receiving stable doses of methotrexate were randomly assigned to 5 mg of tofacitinib bid, 10 mg of tofacitinib twice daily, 40 mg of adalimumab SQ once every 2 weeks, or placebo. At the end of 3 months, patients in the placebo group who did not have a 20% reduction from baseline in the number of swollen and tender joints were switched in a blinded fashion to either 5 mg or 10 mg of tofacitinib bid for another three months. The three primary outcome measures were ACR 20, HAQ-D and DAS28.
Measure | 5 mg bid | 10 mg bid | Placebo | Humira | Power |
ACR20 | 51.5% | 52.6%, | 26.7% | 47.2% | P<0.001 for all vs placebo |
HAQ-DI | −0.55 | −0.61 | −0.24 | -0.49 | P<0.001 for all vs placebo |
DAS28 | 6.2% | 12.5% | 1.1% | 6.7% | P<0.05 for 5mg bid and Humira vs placebo, <0.001 for 10mg bid vs placebo |
On the safety side, rates of adverse events were higher in treated groups than placebo, but comparable between treated groups, infections being the most common. Rates of serious adverse events were higher in tofacitinib 5 mg bid, but comparable between Humira and 10 mg bid.
Pfizer was brave in going up against Humira, probably the market leader amongst the anti-TNFs. By showing similar efficacy (if not slightly better), it can change the paradigm of treating RA.
Finally, in the third study, Pfizer evaluated the efficacy of tofacitinib in patients with Ulcerative Colitis who had failed conventional treatment. In a phase II study, the efficacy of tofacitinib in 194 adults with moderately to severely active ulcerative colitis was compared to placebo. Patients were randomly assigned to receive tofacitinib at a dose of 0.5 mg, 3 mg, 10 mg, or 15 mg or placebo bid for 8 weeks. The primary outcome was a clinical response at 8 weeks, defined as an absolute decrease from baseline in the score on the Mayo scoring system of 3 or more, relative decrease from baseline of 30% or more with an accompanying decrease in the rectal bleeding subscore of 1 point or more, or an absolute rectal bleeding subscore of 0 or 1.
Measure | 0.5 mg bid | 3 mg bid | 10 mg bid | 15 mg bid | Placebo | P value |
Mayo score | 32% | 48% | 61% | 78% | 42% | Only significant for 15 mg bid versus placebo |
Clinical Remission | 13% | 33% | 48% | 41% | 10% | Only 0.5 mg bid not significant versus placebo |
Endoscopic Response at 8 weeks | 52% | 58% | 67% | 78% | 46% | Only significant for 15 mg bid versus placebo |
Patients in the 15 mg group also showed significant improvements over placebo-treated patients for endoscopic outcomes, C-reactive protein concentrations, fecal calprotectin concentrations, and Inflammatory Bowel Disease Questionnaire scores. Safety profile was similar to the RA studies, with higher rates of adverse events in treated groups compared to placebo.
While a relatively small study, the data is still encouraging for the use of tofacitinib in ulcerative colitis.
CONCLUSIONS: Tofacitinib is a contender for first line treatment in RA and even as a second line, is a serious challenger to anti-TNFs, based on efficacy, ease of administration, and likely cost. It could also be developed for diseases other than RA, including UC, Crohn's Disease, psoriasis and psoriatic arthritis, and Ankylosing spondyltis. This has the potential to be a great drug for patients and for Pfizer.
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.


text:
Thanks for all the responses, guess I posted right at the lunch-break!
It's a long time LEO friend who told me to be ready to be charged; I was called by the police dept. and told to report to the station later this week for "follow up," that's where he got the "watch your butt on this one" feeling. He gave me the name of a good attorney he's dealt with personally, and I've already consulted. I'll be retaining him if this goes badly.
He says he's seen a lot of stupid stuff, and more than once has seen the "victim" turned into the accused. His argument is a worst-case one (which I appreciate, because I'd rather be prepared than caught off guard). He thinks that if the guy gets a good attorney, he could spin me gripping my pistol as "threatening intent," and that I was "holding this person against their will with a deadly weapon."
I have some friends in the PD here, and they're a mixed bag of opinions. Some are sure that nothing will come back at me, but another is of the "be prepared for the worst, I've seen it happen" mentality.
I work in the defense community, so a lot of my co-workers are former military / LEO. Their opinions have been everything from "walk away and call the cops" to "I'da shot his butt on the spot."
The screwdriver being construed as a weapon is a good point, and you're right, I had no idea whether this guy was armed beyond that or not.
I didn't feel I could walk away and call the cops because as soon as he got her started, all bets were off and he'd have been gone.
I do feel like I was simply protecting my self / property, and I feel that I did so in a completely reasonable way.
Thanks again for everyone chipping in, I really do appreciate getting the input (even if it is an internet forum!).
EDIT - I never draw / aim unless I intend to kill; if I point my weapon at it, it's probably going to find a new home on a cold metal slab (it's a military hold-over I guess); like I said, all he had to do was walk and I probably would have let him go. I've never once drawn my weapon as a civilian.
My hand was on my hip for my own safety (I felt anyway). Like I said, I was pretty shaken, the guy was bigger than me, probably had me be 100lbs+ and 3".


text:
Giorgio Armani Takes Armani Prive Shockingly Futuristic for Spring 2011
Couture Isn't So Dead, After All, According to Givenchy, Dior, Armani, and Chanel Execs
Peep Megan Fox and Rafael Nadal's New Armani Ads
Even More Spring 2011 Ads Have Turned Up — A Look at Dior, Prada, Armani, Bottega Veneta, and More
Link Time!!!
Lane Crawford's Sarah Rutson Not Taking Barneys Fashion Director Gig; British Fashion Awards to Honor Alexander McQueen
Let the Pre-Fall 2011 Fashion Festivities Begin!
Link Time!!!
Go Behind the Scenes at Megan Fox's Armani Shoot
Vladimir Restoin Roitfeld's Latest Art Show Sells Out in One Night
From Runway to Real Way: Salma Hayek Tries the Turban Trend
Backstage Snaps from Milan Fashion Week Part Four: Daria Strokous's Birthday Surprise at Jil Sander, and More


text:
"Worth it, even if you're not a fan of "classics""
A well done reading of a story worth hearing.
I'm not a huge fan of classic literature, but this story is still relevant and powerful, particularly if you know any sullen young "intellectual" men with chips on their shoulders, or happen to be one.
"Snow Crash Redux"
If you like Neal Stephenson, you should love this. While Diamond Age is my favorite of his works, I think his skills improve with each book he writes.
The only book of his I've read and been underwhelmed by was Snow Crash, and I feel like Reamde was his return to, and successful re-imagining of, the cyber-punk, MMORPG-based novel.
Thanks Neal! Keep 'em coming!
AWESOME! This guy is among the best audio book performers I've ever heard! As much as I enjoyed the book, I actually think Hillgartner's reading made it even more enjoyable than it would have been in print. His accents were fun and well-differentiated! I always knew who was talking, and it spiced up some already atomically spicy characters.


text:
My Wayfair |
See All Trending Items » | |||
New! 12 Remodeling Projects That Add Value » |
New! Contemporary Living Room Photos » |
Samsung 26 Cu. Ft. French Door Refrigerator
Samsungs RF263BEAE Energy Star 26 Cu. Ft. French Door Refrigerator has a large storage capacity and an external water and ice dispenser. The IceMaster icemaker makes up to 10 lbs. of ice per day so you are sure to have plenty for family and friends. The Power Freeze and Power Cool feature drops the temperature in each compartment within minutes. The Twin Cooling Plus System and Cool Select Pantry with temperature control will keep your food fresher, longer. Plus, you will save money while conserving energy with this Energy Star-rated refrigerator, and a handy alarm alerts you when the door is left ajar or open for too long. This refrigerator has space for everything and the cooling technology to keep it all fresh.
Energy Guide Information:
Samsung 26 Cu. Ft. French Door Refrigerator
Weights & Dimensions
Product Type: French door refrigerator | Number of Items Included: 1 |
Display Screen: LED | Water Dispenser: Yes
Ice Maker: Yes
| Freezer Included: Yes
Interior Light: Yes
| Drawers Included: Yes
Shelving Included: Yes
| Number of Doors: 3 |
Door Storage: Yes
| Door Ajar Alarm: Yes |
Concealed Hinges: Yes | Defrost Type: Automatic |
Optimal Air Flow: Yes | Temperature Management: Yes |
Refrigerator Capacity: 26 Cubic Feet | Commercial Use: No |
Recycled Content: No | Country of Manufacture: Korea, Republic of |
Primary Material (Smooth Black, Smooth White Finish): Other
| Primary Material (Stainless Platinum, Stainless Steel Finish): Stainless steel |
Assembly Required: No | Installation Required: Yes |
Additional Parts Required: No |
Product Warranty: 1 year on parts and labor, 5 years on sealed system parts and labor |
Energy Star Compliant: Yes | CEE Rating: Tier III |
About the Manufacturer
For over 70 years, Samsung has been dedicated to making a better world through diverse businesses that today span advanced technology, semiconductors, skyscraper and plant construction, petrochemicals, fashion, medicine, finance, hotels, and more. Their flagship company Samsung Electronics, leads the global market in high-tech electronics manufacturing and digital media.Samsung 26 Cu. Ft. French Door Refrigerator
Still have questions about this product? We're here to help
Customer Reviews
5 star | 1 | |
4 star | 0 | |
3 star | 0 | |
2 star | 0 | |
1 star | 0 |
26 Cu. Ft. French Door Refrigerator is also sometimes listed under the following manufacturer numbers: RF263BEAEBC, RF263BEAESP, RF263BEAESR, RF263BEAEWW


text:
The information contained within this update is obtained from data provided by Ministries of Health of Member States and National Influenza Centers through reports sent to Pan American Health Organization (PAHO) or updates on their web pages.
To download the full report in PDF click here .
Weekly Update
- In North America, acute respiratory disease activity remained stable and is lower than expected in most areas.


text:
Featured Vehicles Woodbridge VA 22191
Chevrolet Corvette Z16 Grand Sport w/4LT
Chevrolet Aveo
Chevrolet Malibu 1LT
Chevrolet Impala LT
Chevrolet Camaro ZL1
We have a great selection on our lot right now. Like this 2010 Chevrolet Corvette. It comes equipped with all the standard amenities for your driving enjoyment. Familiarize yourself with the 2011 Chevrolet Aveo. This vehicle is a triumph, continuing to deliver top-notch execution in its segment…


text:
September 03, 2009 (The Editor's Desk is updated each business day.)
Second quarter 2009 productivity growth revised
Measure | Original | Revised |
Productivity (Output per hour) |
6.4 | 6.6 |
Output |
-1.7 | -1.5 |
Hours |
-7.6 | -7.6 |
These data featured in the TED article, Second quarter 2009 productivity growth revised.
Three recent editions of Spotlight on Statistics
Housing: before, during, and after the Great Recession
looks at consumer expenditures on household items, employment in residential construction, prices for household items, and injuries in occupations involved in building and maintaining our homes. -
Women veterans in the labor force examines the demographic, employment, and unemployment characteristics of women veterans.
BLS Statistics by Occupation provides an overview of occupational employment and wages with an emphasis on STEM jobs and occupational data by typical entry-level education required.