text:
Find out how to access preview-only content
Evaluation of Molecular Similarity and Molecular Diversity Methods Using Biological Activity Data
- Peter Willett
- … show all 1 hide
This chapter reviews the techniques available for quantifying the effectiveness of methods for molecular similarity and molecular diversity, focusing in particular on similarity searching and on compound selection procedures. The evaluation criteria considered are based on biological activity data, both qualitative and quantitative, with rather different criteria needing to be used depending on the type of data available.
- Johnson, M. A. and Maggiora, G. M. (eds.) (1990) Concepts and applications of molecular similarity. Wiley, New York.
- Dean, P. M. (ed.) (1994) Molecular similarity in drug design. Chapman and Hall, Glasgow.
- Willett, P., Barnard, J. M., and Downs, G. M. (1998) Chemical similarity searching. J. Chem. Inf. Comput. Sci. 38, 983–996.
- Dean, P. M. and Lewis, R. A. (eds.) (1999) Molecular diversity in drug design. Kluwer, Amsterdam.
- Ghose, A. K. and Viswanadhan, V. N. (eds.) (2001) Combinatorial library design and evaluation: principles, software tools and applications in drug discovery. Marcel Dekker, New York.
- Kubinyi, H. (1998) Similarity and dissimilarity—a medicinal chemist's view. Perspect. Drug. Discov. Design 11, 225–252. CrossRef
- Martin, Y. C., Kofron, J. L., and Traphagen, L. M. (2002) Do structurally similar molecules have similar biological activities? J. Med. Chem. 45, 4350–4358. CrossRef
- Salton, G. and McGill, M. J. (1983) Introduction to modern information retrieval. McGraw-Hill, New York.
- Frakes, W. B. and Baeza-Yates, R. (eds.) (1992) Information retrieval: data structures and algorithms. Prentice Hall, Englewood Cliffs, NJ.
- Sparck Jones, K. and Willett, P. (eds.) (1997) Readings in information retrieval. Morgan Kaufmann, San Francisco, CA.
- Edgar, S. J., Holliday, J. D., and Willett, P. (2000) Effectiveness of retrieval in similarity searches of chemical databases: a review of performance measures. J. Mol. Graph. Model. 18, 343–357. CrossRef
- Kearsley, S. K., Sallamack, S., Fluder, E. M., Andose, J. D., Mosley, R. T. and Sheridan, R. P. (1996) Chemical similarity using physiochemical property descriptors. J. Chem. Inf. Comput. Sci. 36, 118–127.
- Gillet, V. J., Willett, P., and Bradshaw, J. (1998) Identification of biological activity profiles using substructural analysis and genetic algorithms. J. Chem. Inf. Comput. Sci. 38, 165–179.
- Güner, O. F. and Henry, D. R. Formula for determining the "goodness of hit lists" in 3D database searches. At URL http://www.netsci.org/Science/Cheminform/feature09.html.
- Güner, O. F. and Henry, D. R. (2000) Metric for analyzing hit lists and pharmacophores. In Pharmacophore perception, development and use in drug design, Güner, O. (ed.), International University Line, La Jolla, CA, pp. 193–212
- Raymond, J. W. and Willett, P. (2002) Effectiveness of graph-based and fingerprint-based similarity measures for virtual screening of 2D chemical structure databases. J. Comput.-Aid. Mol. Design 16, 59–71. CrossRef
- Pepperrell, C. A. and Willett, P. (1991) Techniques for the calculation of three-dimensional structural similarity using inter-atomic distances. J. Comput.-Aided Mol. Design 5, 455–474. CrossRef
- Briem, H. and Lessel, U. F. (2000) In vitro and in silico affinity fingerprints: finding similarities beyond structural classes. Perspect. Drug Discov. Design 20, 231–244. CrossRef
- Cohen, J. A. (1960) A coefficient of agreement for nominal scales. Educ. Psychol. Measure. 20, 37–46. CrossRef
- Cohen, J. A. (1968) Weighted kappa: nominal scale agreement with provision for scale disagreement or partial credit. Psychol. Bull. 70, 213–220. CrossRef
- Rand, W. M. (1971) Objective criteria for the evaluation of clustering methods. J. Amer. Stat. Assoc. 66, 846–850. CrossRef
- Wilton, D., Willett, P., Mullier, G., and Lawson, K. (2003) Comparison of ranking methods for virtual screening in lead-discovery programmes. J. Chem. Inf. Comput. Sci. 43, 469–474.
- Egan, J. P. (1975) Signal detection theory and ROC analysis, Academic Press, New York.
- Cuissart, B., Touffet, F., Crémilleux, B., Bureau, R., and Rault, S. (2002) The maximum common substructure as a molecular depiction in a supervised classification context: experiments in quantitative structure/biodegradability relationships. J. Chem. Inf. Comput. Sci. 42, 1043–1052.
- Adamson, G. W. and Bush, J. A. (1973) A method for the automatic classification of chemical structures. Inf. Stor. Retriev. 9, 561–568. CrossRef
- Adamson, G. W. and Bush, J. A. (1975) A comparison of the performance of some similarity and dissimilarity measures in the automatic classification of chemical structures. J. Chem. Inf. Comput. Sci. 15, 55–58.
- Willett, P. and Winterman, V. (1986) A comparison of some measures for the determination of inter-molecular structural similarity. Quant. Struct.-Activ. Relat. 5, 18–25. CrossRef
- Brown, R. D. and Martin, Y. C. (1996) Use of structure-activity data to compare structure-based clustering methods and descriptors for use in compound selection. J. Chem. Inf. Comput. Sci. 36, 572–584.
- Brown, R. D. (1997) Descriptors for diversity analysis. Perspect. Drug Disc. Design 7/8, 31–49.
- Bayada, D. M., Hamersma, H., and van Geerestein, V. J. (1999) Molecular diversity and representativity in chemical databases. J. Chem. Inf. Comput. Sci. 39, 1–10.
- Snarey, M., Terret, N. K., Willett, P., and Wilton, D. J. (1997) Comparison of algorithms for dissimilarity-based compound selection. J. Mol. Graph. Model. 15, 372–385. CrossRef
- Matter, H. and Potter, T. (1999) Comparing 3D pharmacophore triplets and 2D fingerprints for selecting diverse compound subsets. J. Chem. Inf. Comput. Sci. 39, 1211–1225.
- Patterson, D. E., Cramer, R. D., Ferguson, A. M., Clark, R. D., and Weinberger, L. E. (1996) Neighbourhood behaviour: a useful concept for validation of "molecular diversity" descriptors. J. Med. Chem. 39, 3049–3059. CrossRef
- Waldman, M., Li, H., and Hassan, M. (2000) Novel algorithms for the optimisation of molecular diversity of combinatorial libraries. J. Mol. Graph. Model. 18, 412–426. CrossRef
- Ferguson, A. M., Patterson, D. E., Garr, C. D., and Underiner, T. L. (1996) Designing chemical libraries for lead discovery. J. Biomol. Screen. 1, 65–73. CrossRef
- Bayley, M. J. and Willett, P. (1999) Binning schemes for partition-based compound selection. J. Mol. Graph. Model. 17, 10–18. CrossRef
- Golbraikh, A. and Tropsha, A. (2002) Predictive QSAR modeling based on diversity sampling of experimental datasets for the training and test set selection. J. Comput.-Aid. Mol. Design 16, 357–369. CrossRef
- Dixon, S. L. and Merz, K. M. (2001) One-dimensional molecular representations and similarity calculations: methodology and validation. J. Med. Chem. 44, 3795–3809. CrossRef
- Coats, E. A. (1998) The CoMFA steroids as a benchmark dataset for development of 3D QSAR methods. Perspect. Drug Discov. Design 12/14, 199–213. CrossRef
- Cramer, R. D., Patterson, D. E., and Bunce, J. D. (1988) Comparative molecular field analysis (CoMFA). Effect of shape on binding of steroids to carrier proteins. J. Am. Chem. Soc. 110, 5959–5967. CrossRef
- Title
- Evaluation of Molecular Similarity and Molecular Diversity Methods Using Biological Activity Data
- Book Title
- Chemoinformatics
- Book Subtitle
- Concepts, Methods, and Tools for Drug Discovery
- Pages
- pp 51-63
- Copyright
- 2004
- 10.1385/1-59259-802-1:051
- Print ISBN
- 978-1-58829-261-2
- Online ISBN
- 978-1-59259-802-1
- Series Title
- Methods in Molecular Biology™
- Series Volume
- 275
- Series ISSN
- 1064-3745
- Publisher
- Humana Press
- Copyright Holder
- Humana Press
- Additional Links
- Topics
- Keywords
- Chemical database
- compound selection
- library design
- molecular diversity
- molecular similarity
- neighborhood behavior
- similar property principle
- similarity searching
- Industry Sectors
- Editors
- Jürgen Bajorath (1) (2)
- Editor Affiliations
- 1. Albany Molecular Research Inc., Bothell Research Center
- 2. University of Washington
- Authors
- Peter Willett (3)
- Author Affiliations
- 3. Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, Sheffield, UK
Continue reading...
To view the rest of this content please follow the download PDF link above.

subset: commoncrawl


text:
{{ title }}
{{ link.name }}EXPLORE THE NEW ISTOCK EXPERIENCE
Members of the Household cavalry in the grounds of Windsor Castle in... News PhotoArts Culture and Entertainment,Berkshire,Cavalry,Domestic Life,Grounds,Horizontal,International Landmark,London - England,People,Royalty,UK,Windsor - England,Windsor CastlePhotographer AFPCollection: AFP 2014 AFPMembers of the Household cavalry in the grounds of Windsor Castle, in Windsor, west of London on April 8, 2014. Ireland's Michael D. Higgins is making the first state visit by a president of the republic since it gained independence from neighbouring Britain. The visit comes three years after Queen Elizabeth II made a groundbreaking trip to the republic, which helped to heal deep-rooted unease and put British-Irish relations on a new footing. Higgins' return visit will be seen as an official sign of further progress following the hard-won peace in Northern Ireland, which remains part of the United Kingdom. AFP PHOTO / POOL / STEVE PARSONS (Photo credit should read Steve Parsons/AFP/Getty Images)


text: Presidential Image Gallery President Clinton with Arafat, Netanyahu, and King Hussein October 02, 1996 Source: William J. Clinton Presidential Library President Bill Clinton made several attempts to bring peace and stability to the Middle East. Clinton, standing far right, held negotiations with, from left to right, PLO leader Yasser Arafat, Israeli Prime Minister Benjamin Netanyahu, and King Hussein of Jordan in October 1996. The negotiations were largely unsuccessful. ← Return to Bill Clinton Gallery Presidents George Washington John Adams Thomas Jefferson James Madison James Monroe John Quincy Adams Andrew Jackson Martin Van Buren William Harrison John Tyler James K. Polk Zachary Taylor Millard Fillmore Franklin Pierce James Buchanan Abraham Lincoln Andrew Johnson Ulysses S. Grant Rutherford B. Hayes James A. Garfield Chester A. Arthur Grover Cleveland Benjamin Harrison William McKinley Theodore Roosevelt William Taft Woodrow Wilson Warren G. Harding Calvin Coolidge Herbert Hoover Franklin D. Roosevelt Harry S. Truman Dwight D. Eisenhower John F. Kennedy Lyndon B. Johnson Richard Nixon Gerald Ford Jimmy Carter Ronald Reagan George H. W. Bush Bill Clinton George W. Bush Barack Obama


text: ENTERTAINMENT Entertainment Galleries Rear Of The Year © Getty Images Bond Girls Gallery Bond Girls Gallery Leonardo DiCaprio's Girlfriends Leonardo DiCaprio's Girlfriends The Best (Worst) Of Rep.Weiner's Erotic Texts The Best (Worst) Of Rep.Weiner's Erotic Texts The Best Of Weiner's Erotic Texts The Best Of Weiner's Erotic Texts Coming Next OR 0 5 Back to Top ▲ Rear Of The Year Rear Of The Year Kim Kardashian AskMen Staff Share on Facebook Share on Twitter 0 Shares We can't even begin to imagine how much wax they required at Madame Tussauds when making a life-size replica of reality star Kim Kardashian. Her behind gets more limelight than her heels get shade, and bikini pictures of Kim's bottom are the stuff of Twitter legend.[polldaddy poll="5125283"] Next Page Comments Show Comments More Like This Promoted Around the Web Special Features


text:
The stealth black iGlaze Ultra Slim Case for MacBook Pro 15" with Retina Display from Moshi is a two-piece customized polycarbonate housing that protects the top and bottom of your laptop from scratches. The specialized coating is designed to both enhance its appearance and safeguard your Mac from incidental contact.
The casing is lightweight and, when installed, maintains the overall thin profile of your laptop. It rapidly installs with seven micro-clips on the top cover and two on the bottom half. The cover does not interfere with access to all ports as well as the laptop's MagSafe connector. The bottom contains raised rubber feet to free up the vents and expedite heat dissipation. The iGlaze Ultra Slim Case for MacBook Pro 15" with Retina Display is backed by a limited lifetime warranty from Moshi.
- Durable polycarbonate covering that protects top and bottom of your MacBook Pro 15" with Retina Display
- Special coating on cover guards against scratches
- Easy installation using Moshi's micro-clips on top/bottom
- Keeps the thin profile of your laptop intact


text:
Home / Media / Article
January 30 2008
Allison Kasic
IWF's Allison Kasic and Halima Karzai discuss the challenges of curbing poppy cultivation in Afghanistan.
CAROLINE KITCHENS "[I]t's a shame that feminists who claim to be all about empowering women are teaching young girls that they will always be victims and that the cards are stacked against them. I just don't think that's true in our society anymore, and we're sending a horrible message to girls by teaching them to embrace victim status."READ MORE >>>


text:
My thoughts on Etta James...
Her raw tone and the passion she put forth on a record spoke to me at a very young age and has continued to influence and inspire me throughout my career. She will NEVER be forgotten, her voice will forever live on and she will inspire talent for generations to come.
Add a comment
Today's perfomance at the funeral... I have no words.
Christina Aguilera's vocal skills are waaayyy tooo epic for words.
Christina Aguilera's voice is too outstanding and incredible. I've been following Christina's career + music + performances very closely since 1999 and still... today... I remain extremely impressed and baffled by all the majestic, epic talent...
ONLY Christina Aguilera can make me get teary-eyed from a simple vocal performance!!!! Towards the end, a couple of tears even ran down my cheeks... LOL.
Etta James would have liked that performance!!!!!!!!!!!!! So genuine and powerful...
Incredible. Amazing. Christina Aguilera will always be my favorite singer worldwide.


text:
Atlantis Day 2: Coldplay song evokes bittersweet moment for space shuttle
To NASA workers and shuttle fans, Coldplay's "Viva La Vida" as Atlantis's Saturday wakeup call was a wistful tribute to a vehicle that has been the leading symbol of America's space program.
When astronauts aboard the space shuttle Atlantis got their musical "wakeup call" from earth on Saturday, the audio blended haunting instrumentals with a not-so-subtle message: An era of American space travel is ending.
The song was Coldplay's "Viva La Vida," which leads off with the line "I used to rule the world."
To NASA workers and to shuttle fans alike, the song served as a wistful tribute to a vehicle that for three decades has been the leading symbol of America's space program. The current mission, by the Atlantis orbiter, is the final one.
RECOMMENDED: After the space shuttle, astronaut corps awaits a new mission
Since the first launch in 1981, the orbiters may not have literally ruled the world, but they did soar above it. They helped to maintain US leadership in space exploration, even as they also built bridges beyond US borders by serving the International Space Station.
As the song faded out, Atlantis pilot Doug Hurley responded, "Thanks for that great message and awesome ride to orbit, and the 134 before that with this tremendous space shuttle program."


text:
Arthur Kirkland sat on the couch, his legs crossed, reading the newspaper. He was enjoying the somewhat peace and quiet that was going on in the house. Alfred was sleeping in the arm chair, quietly snoring and probably dreaming about hamburgers. This gave Arthur some time to himself. However, he felt something was missing.
As much as Arthur loved keeping to himself once in awhile, he always knew that he couldn't be happy without his one love; [First Name] [Last Name]. He loved everything about her. The wonderful smile she greeted him with every morning, the beautiful look in her [e/c] eyes, the way her [h/c] locks glimmered in the sun, and who could forget the adorable giggle she had? She was Arthur's everything, and he enjoyed every moment of his day when it was spent with her.
That particular day, Arthur hadn't been up early enough to wish [Name] good luck on her way to work. He was afraid that it would upset her as much as it upset himself. He felt as if not seeing his girlfriend off in the morning was a horrible crime. Arthur was always the one to be a kind gentleman.
He checked his watch. [Name] should be home by now... Arthur thought to himself.
He glanced over his newspaper to see out the window. It was pouring outside. His calm and peaceful mood turned into complete worry and despair. What if [Name] wasn't okay? What if she was hurt or something even more horrible?
Suddenly, Arthur heard the unlocking sound of the front door. He put down his newspaper to see [Name] standing in the doorway. She stripped herself of her raincoat and boots. Her face didn't show any spark of happiness whatsoever.
"Good afternoon, love." Arthur greeted her with a smile. "How was your day at work?"
She didn't say anything. She slammed the front door and headed up the stairway.
The slammed door made Alfred awake with quite a fright. "What the hell was that?!"
"It was the door slamming, you frog. And [Name] doesn't seem too happy…"
"Well, she interrupted my amazing dream about marrying a hamburger!" Alfred complained as he curled up into his previous position in the armchair. Arthur glared at the country and arose off the couch to find out exactly what was wrong with [Name].
Arthur headed towards [Name]'s bedroom. Before knocking, however, he put his ear up against the door. He could hear terrible sounding sniffles and sobs. He hesitantly
knocked on the door.
"[Name], can I come in, love?"
She answered with a very choked up, "Yes."
Arthur opened the door to see [Name] curled up at the foot of her bed, bawling hysterically. She was definitely upset. Her face was red as she was attempting to wipe most of the tears away. There were so many coming that it didn't do much good.
As soon as she saw Arthur, she sat upright. She attempted to stifle her whimpering sounds, hoping that he wouldn't notice.
It was obviously that he did notice.
"What's wrong, love?" He asked in his usual, caring tone. He sat next to [Name] on her bed, wrapping an arm around her shoulder. "Did someone give you trouble at work."
[Name] was a fashion designer. Arthur remembered back to the countless times when she would come home in a depressed mood because of coworkers sabotaging her designs or bullying her. She was such a sweet person that she couldn't help but take things to heart.
Arthur handed [Name] a tissue so that she could gain some composure before explaining.
She wiped most of the tears off her face and blew her nose. "I presented my new design today, and my boss… she yelled at me about how completely awful it was… and in front of everyone, too! Now everyone hates me and all of my designs!"
"It's okay, love. It doesn't matter what other people thinks, it just matters about what you think of yourself." Arthur gently kissed her nose, which brought out her trademark smile. "You should be proud of the work that you do, because you worked so hard on your designs."
"B-But…" [Name] hopelessly stammered, "How will I ever become a famous fashion designer if no one else likes my work?"
Arthur picked her up, sitting her carefully on his lap. He then hugged her tightly. "It doesn't matter about those few people at work. Everyone else, including me, loves your designs. Besides, even if you don't become a famous fashion designer… you still have me, love."
[Name] sniffled as tears began to pour down her face. This time, however, they were happy tears. She hugged him tightly around the waist.
"I love you, Arthur."
"I love you too, [Name]."


text:
Yes. The decision to flip the coin and the decision to abide by the coin toss are both yours. Even if the result is heads, you are still free to ignore the result and do B. Both decisions are the product of your will, and in this case your will is not impeded by anything save for your own nature.
I say 'save for your own nature' because it relates to the topic at hand, but really, it's a superfluous statement.
No. A very, very complicated set of physical states produced in you the "decision" to flip the coin. Laws of physics controlled in a nearly-impossible-to-predict but still totally deterministic way whether the coin turned heads or tails. This condition set off a number of other conditions in your brain, with neurons firing in precise patterns that result in your decision. This is, essentially, in no way different from simply thinking about the problem and coming to a decision on your own. All the step of flipping a coin does is use a different set of deterministic, physical principles to end up at your decision. Now, maybe the types of conclusions reached when you use your set of conditions called the brain produces results that make more sense to others than when you use the set of conditions called the coin flip, but in the end it's simply atoms and molecules interacting with other atoms and molecules in exact, deterministic, and insanely complicated way.
In the end, though, I feel this is moot. The human brain is not in any way set up to interpret or handle this kind of worldview. It's fascinating to ponder but useless in any actual implication. The core concepts of things like "society," "morality," and "justice" are technically incorrect but completely vital for people to be happy and fulfilled, because happiness and fulfillment are simply brain states.
Decision should not be in quotation marks. Even under causality, a process occurs that we label as 'choice'. Is it deterministic? Yes, but that doesn't diminish or otherwise alter what it means to make a choice.
Essentially, certain entities can evaluate conditions and effect a course of action on the basis of that evaluation. Humans happen to be capable of doing this. Many people get hung up on the fact that, for whichever choice a person makes, they could have only made that choice and no other (due to causality). When you stop and think about it, that's rather a silly observation. It really only states that a thing can choose what it will choose and cannot choose what it will not choose. What's the point of such tautology?
In both scenarios, causality is at play. Both end results are entirely predictable with sufficient data and understanding of the mechanisms at work. That doesn't mean that the same mechanisms are at work in both scenarios. A unique mechanism at play in the first scenario was choice. It's an important distinction. Understanding that choice actually exists and understanding how it works brings you closer to understanding causality, not further from it.
I don't know, and I don't think it matters really. If I have freewill, I should act based on that fact. If I do not have freewill, my actions are determined by forces beyond my control, so it doesn't matter what I try to do.
Basically, by assuming I have freewill, I can't go wrong, because if I am wrong, there isn't a damn thing I could do about it anyway.
That is very funny, made me laugh out loud.
But if there is no free will it would mean we need to look at criminal behavior differently among of myriad of things. And living life understanding you have no freewill is as freeing as atheism was to me. Both are quite beautiful.
If he has no free will, he is not committing anything. He is being forced by the nature of the universe to do it.
I don't see how punishing people for actions beyond their control makes any sense.
Doctor Reality said, "But if there is no free will it would mean we need to look at criminal behavior differently"
Doug Reardon said, "Does it matter whether a criminal chooses to commit crime, or is impelled to commit crime? It is the crime that society cannot accept, in either case, the source must be removed from society."
Nathan Palo said, "I don't see how punishing people for actions beyond their control makes any sense."
Started by Unseen in Physics, Astronomy, Cosmology. Last reply by Unseen 56 seconds ago. 50 Replies 2 Likes
Started by Unseen in Philosophy. Last reply by Unseen 7 minutes ago. 34 Replies 1 Like
Started by Peter in Religion and the Religious, Atheism and Atheists. Last reply by Erock68la 1 hour ago. 2 Replies 0 Likes
Started by Gallup's Mirror in Showbiz & Celebrity. Last reply by Davis Goodman 1 hour ago. 4 Replies 1 Like
Started by Melvinotis in Art. Last reply by Unseen 12 hours ago. 48 Replies 1 Like
Posted by Nerdy Keith on February 25, 2015 at 8:00pm 2 Comments 1 Like
Posted by Mai on February 25, 2015 at 2:30pm 5 Comments 4 Likes
Advertise with ThinkAtheist.com
© 2015 Created by umar.


text:
News archive page
2 women are behind the viral dress that has everyone confused — Here's what they told us
Two women are behind the viral dress that has...
Business Insider- AdChoicesJDMellbergSponsored
Retirees Could Get Up to a 33% Raise!.
Increase your income in retirement.
No Bra, No Problem: Beyonce Wears a Completely Unbuttoned Shirt to Lunch
Is this a wardrobe malfunction waiting to happen? Beyonce stepped out for lunch with Jay Z at Gracias Madre -- a vegan Mexican restaurant in West Hollywood, Calif. -- on Tuesday, where her denim-on-denim outfit definitely turned plenty of heads. The 33-year-old "Single Ladies" singer knotted her…
ETonlineKanye West Tweets Apology to Beck Following Breakdown During Radio Interview
Kanye West swung by BBC Radio 1's studio Thursday for a candid chat with radio host Zane Lowe. The chat was so candid in fact that West burst into tears halfway through.
Yahoo CelebrityWill Smith Reveals Cause of Struggle in His High-Profile Marriage to Jada Pinkett Smith
Will Smith told Us Weekly and reporters at the Focus premiere that his marriage to Jada Pinkett Smith has experienced its fair share of bumps -- find out their struggle here
Us WeeklyKylie Jenner Just Got a Lot of Decorating Money Thanks to $100 Million Deal
Already have a lot of feelings about 17-year-old Kylie Jenner throwing down $2.7 million for her first house? Just wait until you hear the kind of money she is going to have to decorate it with.
Yahoo Celebrity- AdChoicesSuggest.comSponsored
12 Celeb Couples Who Are All About the PDA
These celebrity couples are experts in PDA. Just try to keep your jealously under control.
Kim Kardashian And Kanye West Mark Their Trip To London With New Tattoo
Kim Kardashian and Kanye West have clearly enjoyed their most recent trip to London. So much so Kanye decided to mark the stay with a very special souvenir….A new tattoo. The superstar couple, who have been in London for Fashion Week, the Brits and Madonna's glitzy secret gig at Annabels, left…
Splash News6 Horrible Things That Happened to 'Top Model' Contestants After the Show Ended
Let's be honest, if Tyra Banks tells you, "Congratulations. You are still in the running to be America's Next Top Model," you're already out of the running to be a real top model. While some contestants have found success -- Analeigh Tipton and Yaya DaCosta, arguably two of the most successful…
ETonlineParents Get Tattoos to Match Daughter's Unique Birthmark
Tanya and Adam Phillips's baby girl Honey-Rae was born with an unusual bright red birth mark on her right foot that travels her leg all the way up to her back.
Yahoo ParentingPregnant Haylie Duff Tried "Fighting the Good Fight" Against Maternity Clothes Despite Her Self-Described "Massive Belly"
Pregnant Haylie Duff revealed to Racked Miami that she tried to avoid maternity clothes but had to succumb because of her self-described "massive belly" -- read her quotes here
Us Weekly- AdChoicesAnswers ScreenSponsored
6 Hollywood Good Girls Who Aren't Actually Sweet
Everyone always assumed that these starlets were the good girls in Hollywood, but it turns out they have some skeletons in their closets, too!
Taylor Swift posted her first bikini pic to Instagram to prevent paparazzi from selling it, after rumors about her belly button
For years, Taylor Swift has been plagued by the...
Business InsiderMatt Hasselbeck re-signs with Colts, ex-Bears RB enjoying acting career and other NFL news
Veteran quarterback Matt Hasselbeck will return to the Indianapolis Colts as Andrew Luck's primary backup, the team announced on Thursday. The 39-year-old signal caller has yet to start a game for the Colts. As a three-time Pro Bowler and Super Bowl starter, he has plenty of experience and…
SB NationZoë Kravitz On Her Weird Teenage Years in Miami
As an actress, performer, and all around "it" girl, the fact that Zoë Kravitz calls Lenny Kravitz her dad is just a bonus that adds to her fame, not the essential factor. Did you know she actually spent her teen years here in Miami? As Ocean Drive's latest cover star, Zoë delves into all things…
Racked MiamiLisa Rinna: My Husband Harry Hamlin Said He'd Divorce Me If I Joined Real Housewives of Beverly Hills
Lisa Rinna admitted during Live! with Kelly and Michael on Wednesday, Feb. 25, that her husband Harry Hamlin threatened to divorce her if she joined The Real Housewives of Beverly Hills
Us Weekly- AdChoicesFreeRateReport.comSponsored
Bad News for Agents, Great for Virginia Drivers
If you are currently insured, have no DUIs, and drive less than 50 miles per day, you may be paying too much for auto insurance. Find out now.
Biebs and Miley move over Kim Kardashian just hit 27M
Kim Kardashian got 27 million followers on Thursday, pushing away Justin Bieber, who in the end of last year still was on the second place.
Zoomin TVKim Kardashian and Kanye West's Epic Backyard, from a Playground for North to a Pair of Pools
Watching Kim and Kanye dote on North is one of life's simplest pleasures.
Yahoo CelebrityBobbi Kristina Brown Placed Back in Coma After Suffering Seizures
Doctors attempted Wednesday to bring Bobbi Kristina Brown out of the medically induced coma she's been in for nearly a month, but were forced to stop their efforts after the 21-year-old began having "violent seizures," Peoplereports. Her father, Bobby Brown, and other family members consider the…
TV GuidePrince William strikes a friendly contrast to Japan's prince
TOKYO (AP) — Britain's Prince William, on his second day of his four-day trip to Japan, is having tea Friday with Crown Prince Naruhito. Both princes may be equally charming, but it is no contest which one is seen as more approachable.
Associated Press- AdChoicesVypedSponsored
9 out of 10 Americans Fail This 8th Grade Quiz
92.4% of Americans Fail This 8th Grade History Quiz. Can YOU Pass It?
Zedd Reveals How He First Met Selena Gomez: "I Had to Pee"
Zedd revealed the awkward moment when he first met rumored girlfriend Selena Gomez — find out!
Us WeeklyIvanka Trump Opens Up About Converting to Judaism
Back in 2009, Ivanka Trump converted to Judaism for her fiance, businessman and New York Observer owner Jared Kushner. They tied the knot in 2010 (mazel tov!), but up until recently, she hadn't divulged too much about her choice to convert or about her life as a Jewish woman.
Yahoo CelebrityJohansson: Nothing 'creepy or inappropriate' about Travolta
Scarlett Johansson defended John Travolta on Thursday, calling the actor "a class act" and denouncing the image of the two on the Academy Awards red carpet as "an unfortunate still-frame" that doesn't reflect a "totally sweet and totally welcome" encounter.
Associated Press


text:
My dog, Fergus, barking.
Levels were a bit high so the sound has clipped. But thanks for making it available.
who let the dog out
Yo dawg awesonme swagy masters bro
Thank you so much.
Used this lovely sound for a kids' iPad app, Draw Your Stories that we did. The app can be downloaded from: https://itunes.apple.com/us/app/draw-your-stories/id646277953?mt=8
I have attributed you in the app's settings page. To know more about the app, you can see: http://www.panipurisoft.com
Thanks so much! Using this for a production of IPHIGENIA AT AULIS by Euripedes, in Sydney Australia.
 |  7 comments
Please log in to comment


text:
Users Online Now:
Who's On?
Visitors Today:
Pageviews Today:
Threads Today:
Posts Today:
Join Our:
GLP Poker Rooms
Check Out:
GiveMeGossip.com - Gossip Forum
Donate To GLP
Adv. Search
Back to Forum
Back to Thread
Message Subject
I am the AC who wrote that vision I had when I was 15. I tuned 44 today. So it begins. Does anyone have any questions or need any encouragement?
Poster Handle
Anonymous Coward
Post Content
Heaven shall not heed your prayers because you have offended God directly and in years to come ye shall have witness in what befalls ye. There is great accountability to hearing directly words from the Spirit of Truth and choosing to act as ravenous wolfs and vipers. It is ye all whom must repent for Heaven abides not with ye and ye shall know soon I spoke the truth. Let the woes to come upon ye humble ye unto repentance to avoid being forsaken.
Spiritoftruth111 33441012
I think praying for one of God's children is not an offense. I heard your words spirit, there something substantial behind them, substance without form holds no jurisdiction. Let God's will control you, He is the master potter after all.
Let Him form you, and soon your substance shall take up a beautiful shape.
It is a offense when you are judging the Almighty God directly ye speak condescending, and think yourself wise and saved and in good favor, but you tread pearls underfoot. You insult me greatly and the warnings given shall be fulfilled for pride offends the Holy-spirit the most and ye though believe in me offend me because of your pride, I have given you more than one chance to repent to avoid consequences but ye shall not listen know that the suffering which comes next in the near future which befalls ye and yours is for your own good for it will help humble ye unto repentance so ye are not forsaken at final judgement. It would have been less if people had to listened but because they are in darkness they could not comprehend the light.
This goes for all of ye whom has judged, spoken against and thought incorrect thoughts against me, Isaiah warned that people would act just as ye all have in this time and he told people what would happen because of it. May all of ye repent and realize your errors.
AlmightyGod 33441012
(The first paragraph is mostly addressed to that CREATURE)
YE this..YE that..YE listen to ME thy GOD or be covered in BOILS..and I will proclaim and decreest DOOMS all over YE that I read somewhere elese and claim its MINE and that I am GOD ALMIGHTY and YE are just doomed sinners who are going to BURN because thou didst nottest HEEDETH unto my Impossible to understand BABBLINGS writtenest in 16th century eglisheth...
Typical religious demons speak.
I tell ya sot..everything that slimy demon is telling you to tell others is EXACTLY what YOU are doing yourself.
But I know its hard for you to see it because it has you BLINDED.
But there was one ting thet Yeshua seemed to specialise in when He was here..OPENING BLIND EYES.
When you meet him...YOU will see..and all this rubbish this creature is getting you to spout like some puppet...will be seen for what it is.
I for one cant WAIT to see the sort of warrior he is going to make of you. And also..because you HAVE been so battered by this thing..you will probably specialise in reaching others JUST as battered as you were.
Please verify you're human:
Reason for copyright violation:
Found: Early Black Hole 12 Billion Times More Massive Than Our Sun
Chemicals From Beauty Products Have Migrated To Antarctica
New Mysterious Craters Found In Siberia
Human Head Transplants Will Not Be Possible By 2017
How Many Constitutional Rights Have We Lost?
North Carolina Legalizes Prostitutes For Politicians
KFC to Serve Edible Coffee Cups
Google wants to rank websites based on facts not links
Eleventh Hour Drama For Net Neutrality
Cyber Bullying Legislation Passes PA House. House Bill 229 would make cyber harassment of a child a punishable offense
DNA Activation for the Golden Age
Are We Living In A Holographic Universe?
Scientists Fear CIA Funding Geoengineering to Control 'Weaponized Weather'
IBM Watson Dehumanizing Veterans Care
Max Keiser: Welcome to the New World Order
Forced Adult Vaccinations at Federal Levels
The Media Is "Run By A Tiny Group Of Politically Motivated Moguls", And "Controlled By The CIA"
Inside The Food Industry: The Surprising Truth About What You Eat
Monday Feb 23 Will Be GLPVCs TheRawFeedLive's Last Show
Hollywood Studio Caught Producing ISIS Videos
A meteor going 45,000 MPH lit up the sky in western PA. You could see it from Ohio and New York!
America : Freedom to Fascism
Rapper Afroman Caught On Video Punching Woman At Nightclub
USDA Approves First GMO Apple For Planting
US Senator used old photos of Russian troops to push Ukraine war propaganda


text:
This is the book lover's community that has been waiting for you. Join us for fun and meet people who share the same love of books that you do. Java Junction is filled with publisher and author groups. Special Interests is filled with hobbies, fun things, cooking tips, recipes, and great things to do. Author's Coffee Corner - Stop by our Author group area and find hundreds of authors who have their Author area with us.
Stop by and say howdy to our newest author, Justus Roux
This month, we have two free seminars..
- March 5-24 - Outline Mistress - Olivia Waite
Coffee Time Romance Event Calendar | Author & Publisher Events Calendar
Yes, I just had a brainwave to go on CTR as FFD. Thanks for your friendship here on CTR.
Hey Lady! Glad you accepted my friendship here. I didn't know we could do this!
Thanks for the friendship, Judith.
Send an Instant Message to Judith Leger Using...
Decaf Coffee Member
Hot Chocolate Member
Forum Mistress
Cappuccino Member


text:
Feb 7, 2011 8:04 AM
8U Girls team looking for practice games (Houston area)
Like (0)
The 8U Katy Extreme girls fastpitch softball team is looking for other 8U teams to play practice games. We are looking for 3-4 teams to setup games on weekends we don't have tournaments. This will keep our costs down and allow our teams to gain more experience. If your team is interested please email me at firstname.lastname@example.com
8U, 8U tournament, 8U scrimmage, 8U games, 8U practice, 8U girls, 8U softball,
Online Golf Tee Times with Last Minute Tee Time Deals & Discounts
Cool Running is the complete online resource for runners.
Find your favorite campground from the best campgrounds listing!


text: The Heinz Kruger wiki last edited by Comicbookman26 on 02/27/15 10:46AM View full history Brief HistoryKruger was a secret agent for the Nazi's whom had infiltrated into the highest ranks of the U.S. Army. He was also one of the Reich's top assassins. One day, his sources told him he was to kill Professor Erskine if the rumors where true that the scientist had created the Super-Soldier Serum. He was told that this would blow his cover and almost certainly mean he would not escape alive. The days before the assasination, Kruger was in a conflict with himself. He wanted to serve his country and make his wife and children proud of him, but he did not know if he could do it. Living in America for so long, he found out that Americans where not that different from his people. They all wanted to be loved and live a good and honrable life. Eventually, Kruger refused to follow his newfound feelings and accepted the assignement. It was then that Kruger, as his American alter ego Fredrick Clemson, joined a few high-ranking American army officers to the Super-Soldier Project. There he was one of the few witnesses to see the birth of Captain America. As Kruger found out the Serum worked, he shot at Captain America and professor Erskine with a gun he had concealed, killing the professor. In his attempted escape, Kruger fell on one of Professor Erskine`s machines where he was electrocuted and died. His actions had made it so that the Super-Soldier Serum died with it's creator, Professor Erskine.Other MediaCaptain America: The first AvengerIn the movie, " Captain America: The First Avenger" (2011), Kruger is one of Red Skull's top assasins and is played by Richard Armitage.


text:
Activity Feed
g Register or sign in to start receiving activity updates from around Kongregate!
Explore Kongregate & earn 10 kreds Here are your 10 free kreds Explore Kongregate & earn a trophy Here's a shiny trophy for you 15%
Keep exploring Kongregate with more badges and games!
Hide the progress bar forever? Yes No
4 posts
Sign in to reply
My Profile Is bladehacks My Other User Hunt Me Please Report Him! :C
U Who Pwned Me!!!
!: what the heck are you saying 2: uh….. i get back to you when i can understand it
Killing users in your team is a ban. KILLING other users in your team. Dont ban them dude.


text:
Hands on: HTC Vive review
Not yet ratedUpdatedWe finally had a proper play and good news - the Vive headset is simply amazing.
UpdatedWe finally had a proper play and good news - the Vive headset is simply amazing.
Combined with Nvidia's Grid gaming service, the Shield is a set-top box that's also a damn powerful gaming machine.
MWC 2015Honor's back again with yet another enticing smartphone offering, this time in the shape of the oddly named 4X.
MWC 2015Another mid-range offering in Archos' growing range of affordable smartphones.
MWC 2015It's not exactly a breath of fresh air, and the design of this mid-range mobile looks suspiciously familiar.
MWC 2015Impressive battery life and a smart design make this BlackBerry handset very attractive.
GDC 2015Does Sony's answer to Oculus Rift, Project Morpheus, have what it takes to compete?
UPDATEDOne of the best smartwatch gets a sequel this May and we've already tried it on at MWC 2015.


text:
In The Artist Studio: Books By Boon
UPDATED 3:01 PM CDT Aug 19, 2013Video TranscriptTHIS STORY. For more on Bill and Kelly Boon and their books, be sure to check out their website: www.books by boon.com
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


text:
Organizations face the serious challenge of outperforming recruitment requirements while managing process efficiency. CareerNet provides recruitment process outsourcing solutions, incorporating speed, accuracy, flexibility and accountability through a team with expertise and focus on each specific process.
CareerNet custom designs recruitment solutions that enable our clients to overcome the complex challenges of managing talent acquisition for their unique and specific requirements, in a marketplace characterized by massive demand and a dearth of appropriate talent.
Recruitment is integral to talent management and requires considerable executive management mindshare. CareerNet helps companies innovate, creating significant positive impact on operating margins. Our success is measured by our clients' ability to achieve business goals.
13.12.09Start-ups see big cos eating into talent pool - heading, LivemintIT professionals sought start-up firms during the downturn as Indian outsourcers and globa...
29.10.09At Microsoft, six Indians call all the shots, Economictimes.indiatimes.comAs the world turned its attention on Microsoft launch of Windows 7, one thing went quietly...
10.09.09 Mid-size cos back to lateral hiring , Thehindubusinessline.comAccording to key HR consultants, lateral hiring is back because the market has improved. M...
CareerNet TEG Analytics Services Study 2008 By CareerNet
Compensation Trends in the Semiconductor and Embedded Design Services Industry By CareerNet
digit Fast Track to TECH CAREERS. Industry pundits help you identify new and emerging career options that will generate your success! - Brought to you in association with CareerNet Consulting
Recruitment Process Outsourcing Manage efficiency and costs in every stage of your recruitment process through our customized outsourcing and management solution; created specifically for your business and recruitment needs. read more
They make the effort to understand the requirements and do not present candidates who are not good fits. As a result they take care of my time not just my needs. They are not afraid to come back and tell me that my requirements are not a good representation of the needs or the market and how i can change the role to better fit what is available. Effectively they help in organizational thinking not just recruiting.
Managing Director, Leading Technology VC Fund


text:
PowerArchiver 2006
A newer version of PowerArchiver 2006 is available.
This download is served from an external site
closeNOTICE: This link will open a connection to a third-party site. CNET cannot ensure the security of software that is hosted on external sites.
Sponsored Products
Full user review
"Great WinZip Alternative"
Some years ago I came to dislike the fact that WinZip didn't natively support many file formats. You had to had external command-line softwares to handle ARJ, LHA and others I don't remember. So I began searching the Internet for an alternative and ended up finding PowerArchiver, which at the time was a freeware. I've been a user since then. And since its interface mimics WinZip there's almost no learning curve. Highly recommended.
Translations have a tendency to lag behind the official English language release. This was worse in the past, but as of today it's still common for both a new version and its translations to not be released at the same time. That's why I usually have the English version installed, even though my license is the (slightly more expensive) international one.


text:
I'm sarcastic a lot. If I offended you I probably didn't mean to. Probably.
here welcome to: forums > entertainment > tv shows > watcha watching? (2013)
TV Shows
Maybe there are lots of other kids who like your favorites show. Talk to them here about you favorite TV shows.
She wrote:
"That's what" ^
This is me while watching a movie
No Spongebob, NOOOO!!
I know I'm every bit Deserving but the Beauty of Grace is that it Makes life not fair~
"Be my escape"
Take a risk. Take a chance. Make a change.♥
B r e a k a w a y ♥


text:
By Sport
- Selected:
- All Sports
- Selected:
By Columnist
By Insider
- Selected:
- All Insiders
- Selected:
By Player
- Selected:
Felix Jones - All Players
- Selected:
By Team
- Selected:
New York Giants - All Teams
- Selected:
49 results for "watkins calvin"
Garrett says Boys committed to run game
Calvin WatkinsOXNARD, Calif. -- To say the Cowboys had a bad rushing attack in 2012 is an understatement. The Cowboys finished 31st in the NFL with a 79.1 yards per game average. The 355 team carries also ranked 31st, marking the first time the Cowboys had fewe...
Blog | July 21, 2013 -
FA update: Chase Blackburn or Kevin Burnett?
Calvin WatkinsThe first day of free agency is over and things will probably slow down a little on Day 2. With that, we review what we heard, saw and talked about Tuesday night and preview what could happen down the line. The loss of John Phillips: The Cowboys l...
Blog | March 13, 2013 -
DeMarco Murray excited for shot at Redskins
Calvin WatkinsIRVING, Texas -- The last time the Cowboys were faced with a win-or-go home situation, running back DeMarco Murray was still recovering from a fractured ankle. The Cowboys lost the 2011 regular season finale at the New York Giants, 31-14. The...
Blog | December 29, 2012 -
Year In Review: Cowboys' top headlines from 2012
Calvin WatkinsThe year got off to an inauspicious start for the Dallas Cowboys, as 2012 began with a loss to the New York Giants on New Year's Day, costing them a playoff berth. Revenge is sweet as the Cowboys avenged the loss with a Week 1 victory over the Gia...
Blog | December 19, 2012 -
W2W4: Cowboys vs. Redskins
Calvin WatkinsARLINGTON -- The Cowboys enter their annual Thanksgiving Day game against their NFC East rivals, the Washington Redskins. Before you fill your belly check out our preview: The series: The Cowboys lead the all-time series, 62-40-2, have won the las...
Blog | November 22, 2012 -
Dez Bryant, Dallas Cowboys WR, active against Atlanta Falcons
Calvin WatkinsDallas Cowboys wide receiver Dez Bryant is a game-time decision for the Sunday night game against the Atlanta Falcons because of a sore hip, according to a source.
Story | Conversation | November 04, 2012 -
Random Thoughts: Bruce Carter has strong effort
Calvin WatkinsIRVING, Texas -- After a review of the Cowboys-Giants II, we offer our weekly Random Thoughts. Enjoy. 1. There were questions last week about whether Bruce Carter can call the defensive signals in place of Sean Lee. Lee is the brains of the Cow...
Blog | October 30, 2012 -
Jerry Jones said he's sick about the loss
Calvin WatkinsIRVING, Texas -- During his twice-weekly radio show, Cowboys owner/general manager Jerry Jones said he's still irked about the 29-24 loss to the New York Giants. "Well, I'm sick," he said Tuesday morning on KRLD-FM. "We had three or four chances t...
Blog | October 30, 2012 -
Cowboys committed to run game, Felix Jones
Calvin WatkinsIRVING, Texas -- The Cowboys rushed for 19 yards on 17 carries Sunday afternoon in the loss to the New York Giants. Felix Jones averaged just 1.5 yards per carry and Phillip Tanner didn't gain any yards on two carries. Coach Jason Garrett said he...
Blog | October 29, 2012 -
Should the Cowboys trade Felix Jones?
Calvin WatkinsARLINGTON, Texas -- The NFL trade deadline is Tuesday and it might be time for the Cowboys to take some calls regarding running back Felix Jones. If any calls are coming in. Jones participated on 62 offensive snaps on Sunday, and carried the ba...
Blog | October 29, 2012 -
Rapid Reaction: Giants 29, Cowboys 24
Calvin WatkinsARLINGTON, Texas -- These games between the Dallas Cowboys and New York Giants are always close. Nearly all of them, it seems. Sunday's was no different, and it came down to the final moments again. The Giants held on for a dramatic 29-24 victory ...
Blog | October 28, 2012 -
DeMarco Murray of Dallas Cowboys ruled out against New York Giant...
Calvin WatkinsAs expected, the Dallas Cowboys ruled out starting running back DeMarco Murray for Sunday's game against the New York Giants.
Story | Conversation | October 26, 2012 -
DeMarco Murray of Dallas Cowboys likely out vs. New York Giants, ...
Calvin WatkinsDallas Cowboys starting running back DeMarco Murray won't practice Wednesday because he's still recovering from a sprained foot, and a source said the team doesn't believe he'll play in Sunday's game against the New York Giants.
Story | Conversation | October 24, 2012 -
Cowboys say 10-day layoff didn't hurt them
Calvin WatkinsSEATTLE -- The Cowboys had 10 days off between the Week 1 victory over the New York Giants and the Week 2 loss to the Seattle Seahawks. Following the loss, several Cowboys players said the layoff didn't hurt the team. But it was clear there was a ...
Blog | September 17, 2012 -
Rapid Reaction: Seahawks 27, Cowboys 7
Calvin WatkinsSEATTLE -- The Dallas Cowboys want to be taken seriously in the NFL. They don't want to be known as a team with all the hype but no substance. The Cowboys didn't respond well Sunday against the Seattle Seahawks. After a 27-7 defeat at Century Link...
Blog | September 16, 2012 -
Is Felix Jones getting kicked off returns?
Calvin WatkinsIRVING, Texas -- With the expected return of cornerback Mike Jenkins to the game-day roster Sunday in Seattle, a trickle-down effect could take place as far as kick returns are concerned. Rookie cornerback Morris Claiborne has gotten work on kick ...
Blog | September 13, 2012


text:
Hotel La Tambra, The Dolimiti Hospitality is known to be excellent, and this is very much confirmed at La Tambra. Super friendly and professional staff in all areas of the hotel, especially in the restaurant. As our youngest child broke his leg on day 2 (bummer), they went the extra mile to make our stay comfortable. Room Service for breakfast,... More
Italy >
Trentino-Alto Adige >
South Tyrol Province >
Corvara in Badia
Price Range (Based on Average Rates):
Number of rooms: 28
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Priceline and Odigeo so you can book your Hotel La Tambra reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


text:
dispositions of engineering at the K–12 level. Some progress has been made in this regard, but more will be necessary to achieve a meaningful consensus.
AAAS (American Association for the Advancement of Science). 1989. Science for All Americans: A Project 2061 Report on Literacy Goals in Science, Mathematics, and Technology. Washington, DC: AAAS.
AAAS. 1993. Benchmarks for Science Literacy. Project 2061. Washington, DC: AAAS.
AAAS. 2001. Atlas of Science Literacy, Volume 1. Project 2061. Washington, DC: AAAS.
AAAS. 2007. Atlas of Science Literacy, Volume 2. Project 2061. Washington, DC: AAAS.
ASEE CMC (American Society for Engineering Education Corporate Member Council). 2008. K–12 STEM Guidelines for All Americans. Available online at http://www.asee.org/activities/organizations/councils/cmc/upload/2009/CMC_K–12_STEM_Guidelines_for_all_Americans.pdf. (January 27, 2010)
CCSSO (Council of Chief State School Officers) and NGA (National Governors Association). 2010. Common Core State Standards for Mathematics. Available online at http://www.corestandards.org/assets/CCSSI_Math%20Standards.pdf. (September 8, 2010)
Childress, V., and C. Rhodes. 2008 Engineering student outcomes for grades 9-12. The Technology Teacher 67(7): 5–12.
Childress, V., and M. Sanders. 2007. Core engineering concepts foundational for the study of technology in grades 6–12. Paper presented the National Symposium to Explore Effective Practices for the Professional Development of K–12 Engineering and Technology Education Teachers. Feb. 11–13, 2007. Dallas/Ft. Worth, Texas. Available online at http://www.conferences.ilstu.edu/NSA/papers/ChildressSanders.pdf. (January 27, 2010)
Custer, R.L., J.L. Daugherty, and J.P. Meyer. 2009. Formulating the conceptual base for secondary level engineering education—a review and synthesis. Paper presented at the NAE Workshop on Standards for K–12 Engineering, Washington, D.C., July 8–9, 2009. Available online at http://www.nae.edu/Programs/TechLit1/K12stds/WorkshoponStandardsforK–12EngineeringEducation/15095.aspx. (January 27, 2010)
Foster, J. 2009. The Development of Technology/Engineering Concepts in Massachusetts Academic Standards. Paper presented at the NAE Workshop on Standards for K–12 Engineering, July 8–9, 2009, Washington, D.C. Available online at http://www.nae.edu/Programs/TechLit1/K12stds/WorkshoponStandardsforK–12EngineeringEducation/15163.aspx. (February 4, 2010)
Hacker, M., M. DeVries, and A. Rossouw. 2009. CCETE Project: Concepts and Contexts in Engineering and Technology Education—Results of the International Research Study. Available online at http://www.hofstra.edu/pdf/Academics/Colleges/SOEAHS/ctl/CTL_Edu_Initiatives_CCETE_revised.pdf. (March 12, 2010)
ITEA (International Technology Education Association). 2000. Standards for Technological Literacy: Content for the Study of Technology. Reston, VA: ITEA.
ITEEA (International Technology and Engineering Educators Association). 2010. ITEA Officially Becomes ITEEA. News release, March 1, 2010. Available online at http://www.iteea.org/AboutITEEA/NameChange.pdf. (April 30, 2010)
Koehler, C., E. Faraclas, S. Sanchez, S.K. Latif, and K. Kazerounian. 2005. Engineering Frameworks for a High School Setting: Guidelines for Technical Literacy for High School


text:
Town Sports International Holdings, Inc. Announces Fourth Quarter And Full-Year 2012 Financial Results
Town Sports International Holdings, Inc. ("TSI" or the "Company") (NASDAQ: CLUB), a leading owner and operator of health clubs located primarily in major cities from Washington, DC north through New England, operating under the brand names "New York Sports Clubs," "Boston Sports Clubs," "Washington Sports Clubs" and "Philadelphia Sports Clubs," announced its results for the fourth quarter and full-year ended December 31, 2012.
Fourth Quarter Overview:
- The Company paid a special cash dividend of $3.00 per share on December 11, 2012. The aggregate amount of the dividends paid totaled $70.3 million with another $1.1 million payable as restricted shares vest.
- Total member count decreased 12,000 to 510,000 in Q4 2012 and decreased by 13,000 for the full-year 2012.
- Membership monthly attrition averaged 3.5% per month in Q4 2012 compared to 3.4% per month in Q4 2011.
- Revenue of $114.2 million in Q4 2012 decreased 1.4% compared to Q4 2011.
- Comparable club revenue decreased 1.1% in Q4 2012.
- Diluted loss per share was $0.02 in Q4 2012 compared to diluted earnings per share of $0.14 in Q4 2011.
- Q4 2012 results reflected the following items amounting to an aggregate net charge of approximately $7.8 million before taxes (approximately $4.3 million net of taxes) or approximately $0.18 per diluted share:
- $3.2 million ($1.9 million net of taxes) of fixed asset write-offs related to four clubs that sustained damage as a result of Hurricane Sandy.
- $1.6 million ($924,000 net of taxes) of incremental interest charges related to expenses incurred in connection with the Q4 2012 additional borrowing under the Company's credit facility.
- $2.5 million ($1.5 million net of taxes) of an equivalent cash bonus paid to certain option holders in connection with the Company's special dividend payment.
- $577,000 ($340,000 net of taxes) of consulting and administration expenses and incremental compensation expense incurred in connection with the Company's special dividend payment and related stock option modifications.
- $340,000 of discrete tax benefits.
- Adjusted EBITDA was $23.2 million in Q4 2012, an increase of $333,000, or 1.5%, when compared to Adjusted EBITDA of $22.9 million in Q4 2011 (Refer to the reconciliation below).
Robert Giardina, Chief Executive Officer of TSI, commented: "We are pleased to have delivered 2012 Adjusted EBITDA of $100 million, modestly exceeding the goal we set for ourselves at the beginning of the year despite the impact of Hurricane Sandy, which resulted in 131 temporary club closures and a decline in member traffic. We are firmly focused on driving personal training and other ancillary revenues and are very excited about the response to new programs like our signature classes, small group training classes and UXF. We also plan to expand our club base, and see opportunities for both acquisitions and new locations in 2013."
Check Out Our Best Services for Investors
Action Alerts PLUS
Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.
Product Features:
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
Quant Ratings
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
Product Features:
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
Stocks Under $10
David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.
Product Features:
- Model portfolio
- Stocks trading below $10
- Intraday trade alerts
Check Out Our Best Services for Investors
Dividend Stock Advisor
David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
Product Features:
- Diversified model portfolio of dividend stocks
- Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks
Every recommendation goes through 3 layers of intense scrutinyquantitative, fundamental and technical analysisto maximize profit potential and minimize risk.
Product Features:
- Model Portfolio
- Intra Day Trade alerts
- Access to Quant Ratings
Options Profits
Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
Product Features:
- Actionable options commentary and news
- Real-time trading community


text:
Workers Know It: In Retirement Planning, They're On Their Own
NEW YORK ( TheStreet) -- When it comes to helping finance their retirement, today's career professionals increasingly believe they're on their own.
That's the conclusion drawn by a study from Financial Finesse, an El Segundo, Calif., personal finance services firm.
According to Financial Finesse's study, Trends in Employee Financial Issues, more and more "employees accept that they can cannot rely on employers to fund their retirement and health care, and instead are taking control of finances themselves."
Clearly, Americans are worried about their financial futures, especially at a time when, by some metrics, their personal financial situations are mediocre at best.
According to Financial Finesse, American workers' money "wellness" scores average 5.2 on a scale of 10 for the first quarter of 2013. The good news there is that metric, which measures eight key financial planning criteria, has risen from 4.9 a year earlier. Maybe it's that "middle of the pack" mentality that is driving U.S. workers to take retirement planning matters into their own hands. The financial wellness study points out that 75% of working Americans say they are working on building "a strong financial foundation" that includes fully leveraging employer financial wellness programs. More specifically, that means employees are plugging into financial advisory webcasts, taking online personal financial assessment tests and taking advantage of on-site visits to talk one-on-one with financial advisers. In addition, more workers told Financial Finesse they were using retirement calculators and taking investment "risk tolerance assessments" to improve their financial plans for retirement. In other words, the Great American Worker is slowly realizing it's up to them to plan a comfortable retirement. "There has been a major paradigm shift in how employees view their benefits and their employers' roles in helping them achieve their financial goals," says Liz Davidson, chief executive at Financial Finesse. "We're seeing that employees, on a mass scale, are proactively taking responsibility for their finances at levels not seen before." That's especially so in training themselves to be better custodians of their own financial resources, a chore that was left to stockbrokers, insurance agents and financial planners only 10 years ago. Sure, those financial professionals are still needed and used, but employees know a lot more about money management today than they did before the Great Recession. "A decade ago, only 5% to 10% of employees took advantage of financial education at their workplace," Davidson says. "Today we're seeing an increasing number of workforces where the majority of employees are participating in financial wellness programs and most employees who use these programs are using them on an ongoing basis." Yet even with all that increased financial knowledge, Americans are still coming up short on retirement plan contributions. Until that changes, Financial Finesse says Americans face a bleak financial future -- no matter how many investment tutorials they take or how many financial calculators they use.Check Out Our Best Services for Investors
Action Alerts PLUS
Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.
Product Features:
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
Quant Ratings
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
Product Features:
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
Stocks Under $10
David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.
Product Features:
- Model portfolio
- Stocks trading below $10
- Intraday trade alerts
Check Out Our Best Services for Investors
Dividend Stock Advisor
David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
Product Features:
- Diversified model portfolio of dividend stocks
- Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks
Every recommendation goes through 3 layers of intense scrutinyquantitative, fundamental and technical analysisto maximize profit potential and minimize risk.
Product Features:
- Model Portfolio
- Intra Day Trade alerts
- Access to Quant Ratings
Options Profits
Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
Product Features:
- Actionable options commentary and news
- Real-time trading community


text:
Adjust Text Size:
Give your favorite foods that great grilled flavor with this nonstick grill. The ribbed surface lifts meat away from grease and fat, while the domed, tempered glass lid allows you to keep an eye on your meal's progress. And, when it's done, the grill even doubles as a serving dish. From Cook's Essentials(R) Kitchenware.
K34672 — CooksEssentials Nonstick Grill w/ Tempered Glass Dome Lid
To choose your shipping method, add this item to your Shopping Cart, continue to Standard Checkout, and make your selection on the Shipping Method page.
Cook's Essentials
CooksEssentials 6 qt. Digital Stainless Steel Pressure Cooker
CooksEssentials 8 qt. Digital Stainless Steel Pressure Cooker
CooksEssentials 5-piece Multi-Tong Utensil Set
CooksEssentials 72"x24" Customizable Silicone Liner


text:
Professional Staff Association
GateWay's PSA needs you!
PSA offers many opportunities for you to get involved. Read on for opportunities to support fundraising efforts, events and elections!
Thank a Gecko ... all year long!
PSA is excited to say that our "Thank-You-Gram" fundraiser was a smashing success! PSA will continue to sell the grams by special order throughout the year. To order grams for your special Gecko(s), contact Janey Buri.
Check back often for the latest PSA Events.
PSA Summer Conference recap
Nearly 300 PSA employees from around the district participated in the PSA Summer Conference – Destination Maricopa on June 12. The event, held at the Arizona Grand Resort, included the induction ceremony for the district's incoming executive board. Guest speakers included Alberto Olivas, director of the Center for Civic Participation, Arizona historian Marshall Trimble, and LaCoya Shelton-Johnson, vice chancellor for human resources. Other highlights included an international panel, a contest for creating a new PSA chant led by Jacque Starks, a funky dancing competition, and many prize giveaways. Congrats to Jolene Mansur at MSC for her big win of a weekend trip to Vegas!
Check out this link for photos of all the fun: PSA Summer Conference 2014
Incoming Executive Board members: Leah Dustin-Hall, president; Yvette Strickling, president-elect; Lynn Mary, past-president; Carmen Gonzales, secretary; Dennis Ellsworth, treasurer; Shannon Ridgeway-Monaco, policy chair; and Ryan Martin, policy rep.
Special thanks to the 2014 conference committee, including Janey Buri and Barb Mazur.
Staff Updates
PSA is rolling out the Welcome Wagon! Be among the first to welcome new PSA members to campus by serving on this new committee. To volunteer for the committee, contact Jessica Brosilo. Learn more about the newest PSAs on campus, and those who have recently made career moves!
Ricky Silva started a new position as Outreach Coordinator in Institutional Advancement. Ricky has been at GateWay for five years and formerly worked as a Health Science Advisor. If Ricky's on vacation, you'll probably find him sipping a margarita on the beach in San Diego – his favorite spot to unwind. Congrats, Ricky!
Professional Growth Online Application
PSA employees can now use Professional Growth funds for textbook reimbursement! Click here for instructions.
In an effort to reduce paper waste and to automate the Professional Growth process, an online version of the Professional Growth system has been developed. In conjunction with the District Office and our sister colleges, the online Professional Growth application is a One Maricopa initiative. Previously, requesting Professional Growth meant filling out forms and mailing them in for approval. The new Professional Growth application has replaced the paper-based system and more!
New Features
- The enhanced forms equal less data entry.
- Online tracking allows a person to check the status of their application in the process.
- Real-time financial indicators show employees the remaining funds they have available.
- An automated approval process routes your request to your PG Reps; there is no more need to mail in paperwork.
- Automated reminders to employees requesting reimbursement to ensure requests are processed quickly if information is missing.
What can I use it for?
- Tuition Applications
- Textbook Reimbursement
- Activity Applications
How to Login
To use the new Professional Growth application, please visit: https://dst.sp.maricopa.edu/dwg/profgrowth. To log into the system, use the following format for your username and password:
- Username: MCCCD-ORG\MEID (Please note that you must use MCCCD-ORG\ before your MEID to be able to access the system.)
- Password: Please use the same password you use to log in to HRMS.
If you experience any problems using the site, please don't hesitate to contact your PG Rep.
Application Deadlines
ALL PSD applications for tuition and activity will be due by the last day of previous month to be considered for the next month's meeting. Applications submitted on the first of the month will not be considered until the following month. For any questions, contact Cindy Cooper at (602) 286-8226.
PSA Officers
Janey Buri | President | (602) 286-8546 | email@example.com |
Barbara Mazur | Treasurer | (602) 286-8477 | firstname.lastname@example.com |
Jessica Brosilo | Secretary | (602) 286-8152 | email@example.com |
Margit Tirpak | Representative - GW | (602) 286-8411 | email@example.com |
Mark Felder | Representative - GW | (602) 286-8644 | firstname.lastname@example.com |
Sarah Risi | Representative - GW | (602) 286-8472 | email@example.com |
David Huiett | Representative - MSC | (602) 238-4313 | firstname.lastname@example.com |
Lindsey Larson | Representative - MSC | (602) 238-0058 | firstname.lastname@example.com |
Debra Phillips | Representative - MSC | (602) 238-4367 | firstname.lastname@example.com |
Cindy Cooper | PSD Rep | (602) 286-8226 | firstname.lastname@example.com |
Cindy Cooper | PEL Rep | (602) 286-8226 | firstname.lastname@example.com |
Ricky Silva | PSI Rep | (602) 286-8230 | firstname.lastname@example.com |