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Call for Sculpture
Tue Feb 01, 2005 23:34
HOTCAKES GALLERY CALL FOR ARTISTS: Outdoor Sculpture Hotcakes Gallery is seeking submissions for its outdoor sculpture garden. The area provides sculptors an opportunity to exhibit medium-scale works in the landscaped garden adjacent to the gallery. This opportunity is open to all professional artists as well as students pursuing undergraduate and advanced degrees. Artists should be familiar with the design, construction, and installation of outdoor sculpture. Works are exhibited on an annual basis from April through ...
Call for Entries: international shorts
Call for Artworks
Tue Feb 01, 2005 19:54
Call for Entries International Shorts is an evening of short works in video and animation screened each May at the California State University Chico, University Film Series Produced by the Department of Art's Electronic Arts Program Festival date: May 10, 2005 Parameters: Short works in video and animation, up to 9 minutes in length. Genre: open Accepted Formats: DVD, CD, mini DV, Digital 8 Please include the following with your submission: Name, Address, Telephone, Email ...
FWD: Two Tenure-Track Faculty Positions in Digital Media (CUNY)
Tue Feb 01, 2005 13:44
-----Original Message----- From: Dutton, Sonia Sent: Tuesday, February 01, 2005 12:58 PM To: Garnett, Joy Subject: didya see this? =) THE GRADUATE CENTER THE CITY UNIVERSITY OF NEW YORK. Digital Media Two Tenure-Track Faculty Positions City University of New York Graduate Center The City University of New York, the nation's largest public urban university, is pleased to announce two tenure-track faculty positions in digital media that will be filled as soon as September 2005. CUNY ...
Exhibition: Ghosts is digital sculpture
Wed Feb 23, 2005 00:00
- Tue Feb 01, 2005
Ghosts 26 February - 23 March 2005 Gallery One, The Herbert, Jordan Well, Coventry, West Midlands CV1 5QP Digital Sculpture at The Herbert Ghosts is a digital sculpture that plays with the notion of 'instant' communication, such as email, web chat and text messages. The projected sculpture is created from the messages visitors contribute through text on a keyboard or mobile phone messages. These words, ideas and fragments of thought are preserved and given a ...
Exhibition: Ghosts is digital sculpture
Wed Feb 23, 2005 00:00
- Tue Feb 01, 2005
Ghosts 26 February - 23 March 2005 Gallery One, The Herbert, Jordan Well, Coventry, West Midlands CV1 5QP Digital Sculpture at The Herbert Ghosts is a digital sculpture that plays with the notion of 'instant' communication, such as email, web chat and text messages. The projected sculpture is created from the messages visitors contribute through text on a keyboard or mobile phone messages. These words, ideas and fragments of thought are preserved and given a ...
Call for videos /// VideoMagazine
Call for Artworks
Tue Feb 01, 2005 00:00
Colegiala en Cinta Vol.2///El Vicio Producciones Bogota, Colombia We invite to submit videos for the second issue of our video magazine. EL VICIO PRODUCCIONES welcomes any type of videoart, experimental video, or home video to participate in this call. The deadline is April 1st, 2005. Please send a DVD with your video to the following address. EL VICIO PRODUCCIONES Cra. 9 No. 58-47 Of. 203 Attn. Simon Hernandez Please contact us with any question or ...
END/BEGIN: Toward New Models of Activism. 2/4/05.
Fri Feb 04, 2005 00:00
- Mon Jan 31, 2005
Announcing: END/BEGIN: Toward New Models of Activism Panel Discussion. 6:30 PM. Friday, February 4th, 2005. Interactive Telecommunications Program, NYU. 721 Broadway, 4th Floor. New York City. With an eye to the recent past, how might activists revise current models of organization and practice? Which successes and failures in this arena have proven most instructive? What 'real-world' realities prove most problematic to activists and how can these be constructively approached? Speakers: 1. Clay Shirky (Interactive Telecommunications ...
Chris Anthony At L.A. Center For Digital Art
Thu Feb 10, 2005 00:00
- Sun Jan 30, 2005
Chris Anthony "RED WHITE BLACK AND BLUE" February 10-March 4 Reception Thursday February 10 7-9pm Los Angeles Center For Digital Art 107 West Fifth Street Los Angeles, CA 90013 http://www.lacda.com Chris Anthony's series of incisive and witty photographs, titled RED WHITE BLACK AND BLUE, is hard hitting art born out of disgust towards the Bush Administration's policy of spin, dodge, and divert. The digitally manipulated images blast the straight jacketing of civil rights by an ...
Synchronicity Space, T-MINUS 2005
Tue Feb 01, 2005 00:00
- Sun Jan 30, 2005
Here it is there everyone, hope you can make it: http://www.t-minus.org/ *** T-MINUS 2005 *** Presenting the work of emerging artists in the medium of time. 13 digitally altered site-specific timelapse video artworks, by 15 artists from around the world. Opening Reception: THIS TUESDAY, FEB 1 5:30-7:30 Synchronicity Space 106 W. 13th Street (at 6th avenue) New York, NY 10011 Gallery hours: Tuesday-Saturday 12-6 Most changes in the world around us go unnoticed. As computers ...
Queerthology, an LGBTQ youth anthology
Tue Feb 15, 2005 00:00
Queerthology is a project to compile a document of diverse "personal nonfiction" from young writers and artists across the country (aged 13 to 23). We are not only looking for essays and poetry, but graphic essays, photo-essays, comic panels, and other visual mediums. I'd also like to note that the contest isn't a "writing contest" or "art contest." While we wish to compile a quality anthology, diversity and truth of experience are important factors we ...
Linux Virgin 1.1 on view now
Mon Feb 14, 2005 00:00
- Sun Jan 30, 2005
On February 14th 2005 http://www.linuxvirgin.info will begin hosting weekly installments of the linux virgin 1.1-1.5 series, an erotic and informative video series about learning to build a computer to run linux. This amusing series chronicles Karla Grundick, an eager linux groupie schoolgirl, as she is taught how to build a computer by Mistress Koyo, the cyber punk linux expert. Also starring Roy, the voyeur, and Dog Big, the masturbating Rottweiller. series in 5 parts, each ...
Flat is Beautiful at Ocularis
Sun Feb 27, 2005 00:00
- Sun Jan 30, 2005
Flat is Beautiful Sadie Benning, 1998, 56min. Sunday, February 27 at 7 pm Ticket Price $6 Ocularis presents a screening of Sadie Benning's Flat is Beautiful, an experimental live-action cartoon using masks, animation, subtitles, drawings, and dramatic scenes to investigate the psychic life of an androgynous eleven-year-old girl. Growing up in a working class neighborhood with her single mother and gay roommate, Taylor confronts the loneliness of living between masculine and feminine in a culture ...
LEA Special cfp: Locative Media - Deadline 7 March 2005
Sun Jan 30, 2005 08:30
LEA Special Issue: Locative Media * Worldwide Call for Submissions * Guest Editor: Drew Hemment firstname.lastname@example.com http://mitpress2.mit.edu/e-journals/LEA/LEA2004/authors.htm#lmedia The Leonardo Electronic Almanac (ISSN No: 1071-4391) is inviting papers that deal with the emerging data-based spatial practice of Locative Media. Across a broad range of contexts the interface between data environments and location has emerged as a central concern, reversing the trend towards digital content being viewed as placeless, or only encountered in the amorphous space of ...
Call for Participation
Call for Participation
Sun Jan 30, 2005 05:51
FLAG METAMORPHOSES Call for Participation A collaborative / participatory art project for the internet - a continuously growing animation with many authors: The flags of every nation in the world will transform into each another in a flash animation. http://www.thyes.com/flag-metamorphoses Basis for the visual realisation of the flag transformations: 1. The symbols displayed on the flags and their meanings; 2. The relationships between countries - historical, cultural, political, religious, economic. Whereas most flags have predominantly ...
Call for Submissions
Fri Jan 28, 2005 13:51
CALL FOR APPLICATIONS Deadline April 1, 2005 Artists Alliance, Inc./Alianza de Artistas (AAI) is pleased to announce the following opportunity open to visual artists of all disciplines: AAI Lower East Side Rotating Studio Program Two residency sessions: June 5, 2005- Nov. 27, 2005 Dec.4, 2005- May 28, 2006 Deadline for application materials: Postmarked by April 1, 2005 Applications are available at: http://www.artistsai.org/Rotating_Studios/index.html ********** Artists Alliance, Inc./Alianza de Artistas (AAI), a community based nonprofit organization, composed ...

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Texas See And Do
3501 Camp Bowie Boulevard
Fort Worth , Texas
Tel: 817 738 1933
This museum by one of America's greatest architects, Philip Johnson, has long been overshadowed by Kahn's Kimbell, its Cultural District neighbor. But Johnson's hilltop loggia for the Carter Museum is one of his earliest musings in the postmodern vein; Johnson also oversaw a major expansion, which was completed in 2001. The Carter has acquired one of the finest collections of American art anywhere, ranging from 19th-century landscape painters like Thomas Cole and Albert Bierstadt to 20th-century masters such as Georgia O'Keeffe and Stuart Davisas well as Western favorites Frederic Remington and Charles M. Russell. The museum also houses one of the largest and best collections of American photography extant.
Open Sundays noon to 5 pm, Tuesdays, Wednesdays, Fridays, and Saturdays 10 am to 5 pm, Thursdays 10 am to 8 pm.
Zilker Park
Austin , Texas
Tel: 888 512 7469
For more than 30 years, the weekly PBS show Austin City Limits has been a window into the city's incomparable music scene, featuring artists from Willie Nelson to Spoon. Tickets to tapings are free, but they're pretty darn hard to come by. The local radio affiliate, KLRU, announces the location of a giveaway one to two days before the concert: Whoever shows up first at that location gets 'em (limit of two). So you have to be in Austin (and be speedy) to score.
Of course, ACL also puts on the Austin City Limits Festival in September, which leans toward more established acts, from Coldplay to Lucinda Williams. Its party atmosphere is comparable to the annual South by Southwest festival, but it's much easier to navigate. All shows are held in Zilker Park (rather than SXSW's zillion tiny nightclubs around town). Sign up on the ACL site to be alerted to ticket on-sale dates; tickets get more expensive as the event approaches.
Also good to know: Because of the convincing backdrop of the city skyline and other local landmarks, it's a common misconception that the show is filmed outdoors; it's actually shot in a studio on the University of Texas campus.
2101 Barton Springs Road
Zilker Park
Austin , Texas
Tel: 512 476 9044
This spring-fed public pool, framed by sunbather-friendly green spaces and the canopies of ancient pecan trees, is idyllic on a sunny summer day. The water is chlorine-free, and at 68 degrees, it's a bracing eye-opener if you're recovering from a long night on the town. On weekends in fine weather the place is jammed with families, hippies, and young people out to get a nice tan. Tops are optional for women, though you won't see too many women taking advantage of that. There's not much else on-site to speak of, but if you walk up Barton Springs Road a bit you'll find quite a few restaurants and food carts. Don't pass up the snow cones; they really hit the spot in the Texas heat.
Open Fridays through Wednesdays 5 am to 10 pm, Thursdays 5 to 9 am and 7 to 10 pm.
300 through 500 block of North Bishop Avenue, between Davis Street and Jefferson Boulevard
Dallas , Texas
Oak Cliff, or more specifically the affluent Kessler Park neighborhood, across the Trinity River from downtown, proudly considers itself the anti-Dallas, replete with rolling hills, picturesque older homes, and a more contemplative lifestyle. Oak Cliff's Bishop Arts District, a few blocks of recently spiffed-up 1920s storefronts, isn't trying to compete with the architectural firepower of the Dallas Arts District, but its collection of small and independent eateries, shops, and galleries offers pedestrian-friendly charm and funky originality. Shopping venues include Zola's Everyday Vintage with '60s through '80s haute couture; and Ifs Ands & Butts, a tobacco shop that also carries 300 varieties of bottled sodas. Hang out with your pooch at the hip but unpretentious Nodding Dogs Coffee Co. for upscale dining. Hattie's American Bistro serves sophisticated Southern cuisine in a graceful, romantic setting.
8525 Garland Road
Dallas , Texas
Tel: 214 515 6500
Fax: 214 515 6522
One of the nation's biggest and best floral displays is set on the thickly wooded slopes above White Rock Lake, a popular recreation spot close to downtown. Paths shaded by magnolias and crape myrtles wind among immense beds of tulips and azaleas in the spring and chrysanthemums in the fall. A vast variety of vistas makes this a popular place for commercial and amateur photographers: water walls, gazebos, arbors, broad lawns, and myriad fountains and pools, some whimsical (four spouting toads), some ethereally minimalist. A new education center designed by the noted Texas firm Lake/Flato is a series of small classrooms and large pavilions in glass, steel, stone, and wood, a sophisticated modernist interpretation of traditional Texas barns and farmhouses. Picnicking is encouraged.
Open daily 9 am to 5 pm.
1717 North Harwood Street
Dallas , Texas
Tel: 214 922 1200
Though it is the least distinguished architecturally of the area's major museums, Edward Larrabee Barnes' sleek, modern building is dramatically ambitious if somewhat overbearing. The collections broadly survey European, American, Asian, and African art while also showcasing cutting-edge contemporary work, often from some of Europe's biggest stars. Decorative arts are another strength, with a definitive collection of American silver. But the premier collection is ancient art from South and Central America, and it's one of the world's finest, featuring stunning displays of Incan gold and Mayan ceramics. The museum also functions as a site for frequent concerts, readings, and lectures.
Open Tuesdays and Wednesdays 11 am to 5 pm, Thursdays 11 am to 9 pm, Fridays, Saturdays, and Sundays 11 am to 5 pm.
1801 N. Griffin Street
Dallas , Texas
Tel: 214 720 2224
The aquarium isn't the half of this ambitious, privately operated zoological garden in Dallas's West End Historic District. An enormous glassed-in habitat reproduces Venezuela's Orinoco rain forest, monkeys and toucans gambol in the treetops, and crocodiles and manatees swim down below. In the new junglelike eight-story Mundo Maya habitat, hummingbirds and butterflies flit, panthers prowl, and bull sharks lurk over visitors' heads in a glassed-in tunnel. The aquarium has gorgeous saltwater environments ranging from British Columbia (giant octopus) to the reefs of Palau. Have a drink and a bite in the Eighteen-O-One restaurant while the kids go wild.
Open daily 10 am to 5 pm.
1300 Robert B. Cullum Boulevard
Dallas , Texas
Tel: 214 421 9600
Built for the 1936 Texas Centennial, this 300-acre complex of pavilions, pools, and esplanades is the world's largest collection of Art Deco architecture, culminating in the soaring, seven-story blue-tile portico of the Hall of State. Fair Park's nine museums include the African American Museum, the Women's Museum, and the Museum of Nature & Science (with planetarium and IMAX theater). But the real show, from late September to late October, is the annual State Fair of Texas. The Fair is timeless Texana with livestock competitions; a vast, diet-busting food court (where anything that can conceivably be fried is); a sprawling midway; acres of exhibits ranging from prize-winning preserves to imported autos; and official greetings from Big Tex, a 52-foot-tall talking cowboy mannequin.
130 E. Exchange Avenue
Fort Worth , Texas
Tel: 817 624 4741
It began as a stop on the Chisholm Trail and boomed as a raucous meatpacking district at the turn of the 19th century. Now filled with Western-wear shops, Western-style saloons, and barbecue joints and steak houses, it's the reason they still call Fort Worth "Cowtown." Visit the Cowtown Coliseum, where they've been holding rodeos since 1918, and the legendary White Elephant Saloon, with its cowboy-hat-festooned ceiling and Gunsmoke-style stand-up bar. Family-friendly attractions include a twice-daily mini-trail drive, complete with authentically cantankerous longhorns, and the Tarantula Train, an 1896 steam engine that takes visitors on sightseeing junkets along the route of the old Chisholm Trail.
1989 Colonial Parkway
Fort Worth , Texas
Tel: 817 759 7555
One of the nation's top zoos draws raves for its acres of realistic habitats where animals roam free in natural environments. The safarilike African Savanna exhibit offers unique overhead, boardwalk views of white rhinos, ostriches, and giraffes; in the Raptor Canyon aviary, Andean condors and crowned eagles fly overhead. The spectacular hillside Asian Falls habitat includes a colony of elephants and two white tigers, while other evocative environments focus on Komodo dragons, meerkats, or gorillas and orangutans (in a re-created rain forest). Texas Wild features eight acres of the state's flora and fauna set around kid-pleasing regional tableaux, from a tornado-demolished house on the High Plains to a West Texas mineshaft.
Open daily. Late October through mid-February: 10 am to 4 pm. Mid-February through late October: Mondays through Fridays 10 am to 5 pm, Saturdays and Sundays 10 am to 6 pm.
The Hill Country may not be as dramatic as Big Bend or the Piney Woods, but many Texans say it's the most beautiful region in the state. In the spring, when bluebonnets and other wildflowers add a splash of color to the limestone cliffs and live oakcovered hills, it can be downright spectacular. You'll see hordes of families pulling over on the highways to take photos in the flowers. You can see why Lance Armstrong trains here. In fact, cyclists of all types come for the challenging terrain and stunning beauty. Hill Country Bicycle Works in Fredericksburg rents high-quality mountain and road bikes and recommends the best trails (830-990-2609; www.hillcountrybicycle.com). For hiking and camping within an hour of town, drive west on Highway 71 to Llano, then head south on Highway 16 until you reach Enchanted Rock State Natural Area (830-685-3636; www.tpwd.state.tx.us/park/enchantd). Get there early, though, as the park fills up fast. For a more sedentary afternoon, take Farm-to-Market Road 1431 to Marble Falls and savor the chicken-fried steak at the Blue Bonnet Café; (830-693-2344; www.bluebonnetcafe.net). The journey home at sunset is even more enjoyable on a full stomach. Better still is Café 909 (830-693-2126; www.cafe909.com), where the menu goes beyond mere comfort food to haute Texas cuisine with dishes like grilled peaches wrapped in Speck and sprinkled with shaved Parmesan and balsamic syrup.
3333 Camp Bowie Boulevard
Fort Worth , Texas
Tel: 817 332 8451
The anchor of Fort Worth's celebrated Cultural District, Louis Kahn's exquisitely proportioned 1972 building is on most short lists of the 20th century's greatest architectural achievements. A series of travertine-clad barrel vaults bathed in natural light, this sublime modern classic would be worth a visit empty. But the Kimbell's concise collection is uniformly of the highest quality, offering an art-history highlight reel of dozens of masterpieces, from Duccio's The Raising of Lazarus to Poussin's Venus and Adonis to Picasso's Woman Combing Her Hair. Classical, Asian, and pre-Columbian collections are comparably rich. In an art world coup, the museum recently acquired what is believed to be the earliest known painting by Michelangelo, The Torment of Saint Anthony, which dates from 1487-88, when the artist was only 12 or 13.
Open Tuesdays through Thursdays 10 am to 5 pm, Fridays noon to 8 pm, Saturdays 10 am to 5 pm, Sundays noon to 5 pm.
Austin , Texas
It's hard to get more landlocked than the interior of Texas, but Austin has three lakes nearbytwo essentially within townthat on weekends explode into social scenes.
Lady Bird Lake (renamed from "Town Lake" for Lady Bird Johnson, who recently passed away) isn't actually a lake, but rather the Colorado River. The wide part of the river that runs through downtown is ringed by hiking and biking trails; sculling is also popular, though motorboats are prohibited.
Lake Austin sits between two dams on the western edge of town and is rimmed by million-dollar homes; its usually calm surface is perfect for waterskiing. The Hula Hut has a deck on Lake Austin and is massively popular after work (3825 Lake Austin Blvd.; 512-476-4852; www.hulahut.com)probably because the cocktails are better than the food. Next door is Mozart's, whose magical lakefront location makes it one of the most romantic coffee shops in Texasperhaps America (3826 Lake Austin Blvd.; 512-477-2900; www.mozartscoffee.com).
Located 20 minutes outside of town, Lake Travis has more than 270 miles of shoreline. Though there might be fewer cigarette boats spraying rooster tails than in the go-go days of the dot-com boom, the waters are still full of ski boats, and there's as much boat-to-boat socializing as actual waterskiing. A handful of marinas offer day rentals for powerboats, party barges, and wave runners; try Just for Fun (Emerald Point Marina; 5973 Hiline Rd.; 512-266-9710; www.jff.net). Johnny Fins (16405 Clara Van Trail; 512-266-2811; www.johnnyfins.com) and the Lakehouse Café; (512-264-7040; www.lakehousecafe.com; weekends only) are the main options for float-up dining and drinkingbut take heed of strict local policies on drinking and boating. There are several beaches, but the curious steer toward Hippie Hollow, the only public clothing-optional park in the state.
1818 Rodeo Drive
Mesquite , Texas
Tel: 972 285 8777
This big-time professional rodeo is just 15 minutes east of downtown Dallas. The season runs from April through September, but don't worry about the sweltering heat: The 5,500-seat Resistol Arena is fully air-conditioned. If you require further pampering while watching the calf roping, steer wrastlin', and barrel racing, decorated luxury suites offer wet bars and waiters. This very family-friendly environment includes pony rides, a petting zoo, and finger-lickin' BBQ from local legend Sonny Bryan; kids under 55 pounds can even suit up in a helmet and vest just like the pros and ride a sheep (called mutton bustin'). But the marquee bull-riding event, where the one-ton animals usually win, is a dangerous sport for the real pros only.
Open early April through late September; most rodeo events Fridays and Saturdays 8 to 10 pm.
3200 Darnell Street
Fort Worth , Texas
Tel: 817 738 9215
If Louis Kahn's Kimbell Museum is regarded as one of the best buildings of the last century, Tadao Ando's new Fort Worth Modern, just across the street, may well stand up as one of this century's finest. Dramatic, 40-foot-tall Y-shaped concrete columns support the flat, cantilevered roofs of the glassed-in, satiny-gray concrete galleriesthe entire structure seems to float in the immense reflecting pool. The collection stresses Abstract Expressionism, Pop Art, and Minimalism. Touring exhibitions focus on major retrospectives of modern masters. The Café Modern has become a hot luncheon pick.
Open Tuesdays through Saturdays 10 am to 5 pm, Sundays 11 am to 5 pm.
Williams Square Plaza
O'Conner Road, north of Highway 114
Irving , Texas
Tel: 972 869 9047
A depiction of wild horses running through a stream, The Mustangs of Las Colinas is the world's largest equestrian sculpture. Also of interest is an on-site museum that illustrates the process artist Robert Glen had to go through to create this gigantic piece of public art. Commissioned in 1976, the work was intended to catapult the then-tiny development of Las Colinas to larger fame, thus attracting more residents.
Museum open Wednesdays through Saturdays 11 am to 5 pm. Sculpture is accessible 24/7.
2001 Flora Street
Dallas , Texas
Tel: 214 242 5100
The world's hottest museum designer, Renzo Piano, outdid himself with this exceptionally transparent glass, travertine, and aluminum construction in the heart of the Dallas Arts District, across the street from the Dallas Museum of Art. Local collector Raymond Nasher's internationally coveted collection of modern sculpture is revealed in Piano's beautifully bared galleries, which open onto a refined, oasislike sculpture garden. A light supper at Café Nasher on a Thursday evening, when the museum is open late and the lit-up office buildings tower overhead, is a sublimely romantic urban experience.
Open Tuesdays, Wednesdays, Fridays, Saturdays, and Sundays 11 am to 5 pm, Thursdays 11 am to 9 pm.
2201 Road to Six Flags
Arlington , Texas
Tel: 817 530 6000
The flagship Six Flags, midway between Dallas and Fort Worth, features Disneyland-like theme areas dedicated to each of Texas's historic suzerains: Spain, France, Mexico, Republic of Texas, Confederacy, and the United States. The park is a thrill-seeker's paradise, with no less then eight roller coasters, led by the Titan, with its 255-foot, 80-plus-mph first drop. You can also make six upside-down loops on the Flashback or ride beneath the track with your feet dangling on Batman: The Ride. Purists will enjoy the 14-story Texas Giant, the world's best wooden roller coaster. Wind down by going to the top of the Superman Tower of Power for a 30-story free fall.
Open March through December. In-season days and hours of operation vary; for details, call ahead or check online calendar.
411 Elm Street
Dallas , Texas
Tel: 214 747 6660
History doesn't get much more vivid than this high-quality, nonexploitative museum exploring the assassination of President John F. Kennedy in 1963. Located on the sixth floor of the infamous Texas Schoolbook Depository building, the museum features the actual corner window from which Lee Harvey Oswald fired the fatal shots, with a glassed-in re-creation of the barricade of boxes found on November 22. From the next window you can see an Oswald's-eye view of the route the president's motorcade took through Dealey Plaza. Exhibits feature radio and television broadcasts from the fateful day and artifacts such as the camera that recorded the Zapruder film and the forensic model of the assassination site used in the FBI investigation.
Open Tuesdays through Sundays 10 am to 6 pm, Mondays noon to 6 pm.
Tel: 512 467 7979
Every March the big daddy of music events sweeps into town, bringing groups from as far away as Iran and Sierra Leone playing everything from jazz to metal. The emphasis, though, is on indie rockit's sort of like Sundance for the drum-banging set. Shows can be all but impossible to get into without the all-in-one badge (costing in the $600 range), which provides access to all concerts, industry conferences, and the trade show. The badge also grants you access to many of the buzzy, too-cool-for-school private parties hosted by record labels and music mags. Getting around is nearly impossible without a badgesome bars won't even let you in, concert or no concert. However, if you can't drop the cash on a pass, you can see acts at the free outdoor stage at Lady Bird Lake or check out the tamer film fest, where tickets can be obtained much more easily. Still, the frenzy of activity can be thrilling for music buffs, who get to see all of the hottest bands playing tiny venues throughout the city.
3700 Hogge Road
Parker , Texas
Tel: 972 442 7800
Everyone's going to ask if you saw it, so you might as well join the several hundred thousand who traipse through every year. Now operated as a popular site for proms, weddings, and special events, this former horse farm and Dallas television series exterior setit actually looks more like Kentucky than Texasfills in the series backstory with a lavish imagining of how J.R., Sue Ellen, et. al. might have lived at the "Ewing Mansion" (the "real" interiors for the series were shot in Hollywood). At the visitor center, you can also see the gun that shot J.R., and Lucy's wedding dress. Dallas was never like this, and neither was Dallas, but this is a fun, friendly slice of pop cultural history.
Open daily 9 am to 5 pm; last tour begins at 4:30 pm.
Forty minutes south of downtown Dallas, this small town is a museum of picturesque late-19th- and early-20th-century architecture. The centerpiece is the massive nine-story Romanesque Revival Ellis County Courthouse, built in 1897 of pink granite with marvelously carved details in red sandstone (including the emotive faces on column capitals). But the town is full of remarkable Revival concoctions, from the Renaissance Revival library to Victorian Gingerbreadstyle houses; 300 local buildings are on the National Register of Historic Places. The courthouse is surrounded by antiques shops and restaurants. Webb Gallery is one of the nation's top folk art galleries, with art from Texas originals as well as quirky artifacts of small-town culture.


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Current conditions prompt a clear course of action: Water, water everywhere --and maybe a bit of mulch.
Morning is the best time to run a lawn sprinkler.
Our hydrangeas are drooping and our lawns are browning, and, in a perverse way, that makes perfect sense. After all, March was more like May this year, and the calendar has been out of synch ever since.
"In my mind this is more like August, when things might fade but people say 'The heck with it, it's been nice all summer' and just let things go,'" said horticulturist Deb Brown.
Except that we can't do that, at least if we want our plants to be around next spring. Whenever the heck that might come.
The Twin Cities area is not in a severe drought -- yet -- thanks largely to the second-wettest June on record. But after a couple of seriously hot weeks, and with no rain in the 10-day forecast, all but the most venerable plants need some attention.
"We have seen some lawns turn brown, but I'm not overly concerned right now," said Brian Horgan, a turfgrass specialist with the University of Minnesota. "You call me back at the end of July, and it might be a different story."
Lawns that were seeded or sodded this year are most vulnerable, Horgan said, and should be watered thoroughly once a week if there's no rain. The same goes for young trees, large-leafed shrubs and anything in containers.
"You have to meet the demands of the plants," said Brown, former extension horticulturist with the University of Minnesota. "We've had a fair amount of wind and a lot of heat, and the heat has been relentless. Truthfully, there's nothing we can do but water."
Container plants are especially problematic, Brown said, because extra watering can leech away nutrients, so fertilizer should be applied once a week.
Trees and shrubs should not be fertilized during these periods when they are stressed, said Gary Johnson, associate professor of forestry at the University of Minnesota.
He has been watering his own boulevard trees the past two weeks. Heavily. "The old adage of one inch a week, that's for growing corn and bluegrass," he said.
In an era of volatile weather, none of the experts cared to make long-range predictions.
"But if I had to guess," Brown said with a chuckle that sounded more like a sigh, "I'd say it's gonna' stay hot."
Bill Ward • 612-673-7643


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Thailand floods: Water seeps into heart of Bangkok, barriers may not hold
Thailand Prime Minister Yingluck Shinawatra broke from earlier assurances that Bangkok would be safe from Thailand's flooding and announced that flood barriers might not hold.
Damir Sagolj/Reuters
As the most severe flooding to hit Thailand in decades began to enter the heart of Bangkok's temple-dotted, tourist-magnet riverside districts today, Thailand's authorities conceded that there is a high possibility that most of the city's sprawling population of some 12 million could be inundated.
On Tuesday night, Thailand Prime Minister Yingluck Shinawatra broke from earlier assurances that Bangkok could be safe from flooding and announced that "The power of the water is more than the flood barriers and water gates can withstand." She added that "There is a high possibility that water will break into inner and central Bangkok as well as outlying areas."
While most of the city – which satellite images show to be surrounded by a mass of water – remains dry, the rush of water over river barriers today was a reminder of the precarious situation now facing Bangkok, where drinking water, nonperishable foods, and water purification tablets are running low, and threaten to disrupt Thailand's economic zone and tourism industry.
"Now, everything depends on the river, and how high it might get," says Anurak Praeroj, standing knee deep in fast running water and watching his staff line sandbags in front of his boarded up art gallery and cafe in an attempt to stem the flow coming from the river 30 yards behind.
Overflow from the Chao Praya river, which snakes through the city, washed into neighborhoods on both Wednesday, threatening the hospital grounds on one side of the river where 84-year-old King Bhumibol Adulyadej is currently staying. Across the river, the famous Grand Palace and Emerald Buddha are both also threatened. Ankle-deep water lapped at the gates of the Grand Palace by dusk on Wednesday. Farther inside the the city, some government buildings in the Lak Si district were reportedly seeing about 4 inches of water sloshing around their parking lots. Experts say water levels in Bangkok could reach as high as 5 feet if dikes to the north of the capital break.


text: Discuss as: By Photos Sunday May 20, 2007 10:45 AM Email Tweet — You don't normally think of pro athletes as graceful, but this moment reminds me more of ballet than baseball. Each player has a great expression. I wonder why their team names on the uniforms are in English?


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Live: Kiwi bowlers blow away Australia
Boult leads assault as Clarke's men are skittled out for 151 in battle of World Cup co-hosts
Opening of new road sector to ease mainstream traffic flow to Discovery Gardens
Patil, Chandran in demand as they will play against the country of their birth
Living away from family can make people vulnerable to stress, anxiety and depression
One of the three killed was an Emirati police officer
Bomb blast kills Bahraini policeman
Trouble arises from technicality of British electronic visa for Gulf nationals
Obama insists that Al Assad must be 'transitioned out'
Fears growing in Cairo and Riyadh that Al Houthis will control strategic Red Sea shipping lanes
Watch: Video showing scramble for money blown through streets reportedly shot in UAE
'Millions' deposited in Kuwaiti MP bank accounts
Syrian Kurdish forces killed at least 175 members and commanders of the group
Gunman kills seven people, wounds eighth person in an overnight house-to-house rampage
Dubai carrier stopped operating third service after extension expired
Serb battles past Berdych after Swiss legend thrashes teenager Coric
Designer's work will be showcased at Lakmé Fashion Week
For some people, the ability to over indulge in the sweet stuff is no joke
Strike a balance between the luxury spas and beautiful beaches of Hua Hin on the Gulf of Thailand
An Arabian Ranches garden that hints at Arabesque opulence and Asian minimalism
The new restaurant in Dubai takes the joy of grilling to a whole new level
Despite tiny changes, the S6 remains an absolute tour de force
As it marks 100 years of service, the MV Liemba is now an essential lifeline for the people
Most were Rulers' residences, but now serve as museums
What is quickest way to vacate tenants who repeatedly break promises to pay rent?
Caught in the 'upgrade' culture, expats are trading their present for a bad future
Celebrated DJ and producer will perform at Pacha Ibiza Dubai on February 26
Quebec's Ministry of Justice did not immediately respond for comment
Living away from family can make people vulnerable to stress, anxiety and depression
Beijing's crackdown on Uighurs in Xinjiang has been counter-productive
Captain Steve Allright talks about emergency landings, extreme turbulence and MH370
Find out what the stars have in store for you this week
Service expert Ron Kaufman shares tips and tricks to ensure you always get the best attention
Our pick of travel-ready beauty essentials will have you looking first class from boarding to beach
Jet off in style with the ultimate capsule wardrobe
The year's 14 greatest cars go head-to-head for the coveted award
The hooligan of the hot hatch brigade is back, and badder than ever
Celebrating the greatest cock-ups in automotive history. This week we look at the Cadillac XLR
The update will see a new 21in wheel designs, and a power and torque increase for the 6.0-litre W12
It's a Vantage farewell with a special limited-edition track-inspired swansong
Enjoy the modern luxury in this gem of a hotel in the Dominican Republic
Traditional Indian street food is given a contemporary twist in this inspiring new restaurant
The site of a former sheepfold has been transformed into a breathtaking Mediterranean retreat
Funky looks and ideas for kids on the cusp of growing up...
Inspiring buys for the sweetest baby and toddler rooms...
Our pick of the best things to do with kids in Dubai and Abu Dhabi 27 - 28 February
The humble tomato is the star in these tangy and totally tempting dishes
Spend some quality family time by baking these delicious heart-shaped cookies with the kids
With February being the month of romance, we get real on the mistakes women make in love
Beauty writer Sonam Basantani is a bit of a nail addict. She gives us the lowdown on trends, top nail salons and DIY manicures
With roles in two critically acclaimed films, not to mention a Time magazine cover, Jessica Chastain is one of Hollywood's hottest properties in 2015
The true story of a taxi journey that's memorable for all the wrong reasons…
We spoke to John Larkins, President of UAE Touch, about touch rugby's increasing popularity
Seafire Steakhouse and Bar has put a little swing into Wednesdays with food, drink and ambience dedicated to the legendary Frank Sinatra
Mont Blanc's TimeWalker Urban Speed e-Strap combines Swiss watchmaking with wearable technology
Live: Kiwi bowlers blow away Australia2.
'Millions in cash' rain in Kuwait, not Dubai3.
Who gets Dh11,000 minimum wage?4.
Filipino loses Dh7,731 in less than 2 minutes5.
Free holiday for UAE hero Shaiman6.
Monica Bellucci on being oldest Bond girl so far7.
15-car pile-up on Shaikh Zayed Road8.
Dubai tower fire eyewitness accounts9.
Where rents have fallen in Dubai10.
Car catches fire near Garhoud Bridge1.
Filipino loses Dh7,731 in less than 2 minutes2.
Austria to Makkah: man on a mission3.
Lessons from the 'Earth does not rotate' debate4.
Lessons from the 'Earth does not rotate' debate5.
School Transport Services hikes bus fares6.
Free holiday for UAE hero Shaiman7.
'Millions in cash' rain in Kuwait, not Dubai8.
Daesh burns 43 Iraqis alive in Anbar9.
Dubai Zoo tales: what's the real issue here?10.
UK apologises for handcuffing Omani girls


text:
Apollo – in books and movies
The death of Apollo astronaut Neil Armstrong has caused many people to reflect
The death of Apollo astronaut Neil Armstrong has caused many people to reflect
Neil Armstrong, the first human to walk on the Moon, passed away today at the age of 82.
Happy Holidays from Clark Planetarium. The ATK IMAX Theatre will host an extended documentary schedule from December 2 – 15.
Media Contact Sarah Tompkins, Riester 801-532-0623 Darth Vader, Capt. Kirk, Spock, Luke Skywalker, Yoda… You could meet the strangest characters Sept. 22 when Clark Planetarium reaches out to galaxies far, far away and presents its annual fundraiser, entitled this year…
For the record, Clark Planetarium will honor existing printed CityDeals coupons.
Get ready to see some changes in the Hansen Dome Theatre. You won't see the improvements when you walk into the colorfully lit theater to sit down. It's when the lights go down that the magic will shine!
There are times when "Wow!" just isn't enough of a word. Astronomers just released movies made by stitching together 14 years of Hubble Space Telescope images to reveal the beautiful and fascinating movements of stellar gas clouds surrounding newborn stars.
Now that the school year is winding down, it's time to find activities for the kids to enjoy this summer. Summer camps are a great way to introduce children to engaging concepts and help them make new friends. Clark Planetarium…
A membership to Clark Planetarium gives you the best access to the planetarium experience and helps to fund our educational programs. We are excited to release a new benefit package that gives members two years to enjoy added program benefits.…


text:
iTunes commander 1.0
Developed by Luigi de Rosa, listed in Audio
iTunes commander can send AppleScript commands to an instance of iTunes program running on Mac OS X.
iTunes commander can perform operations such as retrieving the name of the song currently playing, moving to the previous or next song or adjusting the sound volume.
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LinkBack | Thread Tools | Display Modes |
11-11-2011, 01:45 PM | #1 (permalink) |
Join Date: Oct 2010
Location: NYC
Posts: 413
List of Bindings by Weight
I saw a couple of threads started about binding weight and since there really isn't sufficient information on the internet about binding weight, I thought it would be a good idea for people to post the weight of their bindings and I'll just update the first post so we can keep a running list of all the bindings.
If anyone has any recommendations just post them here but for now I think posting the year, model, size and weight should be sufficient. I'll try my best to update and list them by weight. I'll weigh my bindings when I get home so at least we can have a start. '12 Flux DMCC-Light: 3.5lb/pair '11 Flux SF45: 5.2lb/pair '10 K2 Auto Uprise (L): 4.15lb/pair Last edited by ecks; 11-11-2011 at 07:21 PM. |
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Courtyard Hotel Kingston Highway 401/Division Street(3 stars)
103 Dalton Ave. Kingston Ontario View on mapHotel review overview
Information about Courtyard Hotel Kingston Highway 401/Division Street
Hotel Information
hotel.de *
Located conveniently off of Highway 401 between Montreal and Toronto, the Courtyard Marriott Kingston's brand new facilities (Including our brand new Water Slide!) are ideal to unwind and re-energize! Business Centre, the Bistro Lounge and Restaurant serving breakfast, dinner, and refreshments, our fabulous indoor pool, slide, fitness facilities, and interactive lobby are unique in Kingston. Benefit from the fabulous Marriott Rewards program each and every stay, and make sure to visit our GoBoard with directions and information on all of Kingston's going-ons! When the day is over, enjoy the comfort of our beautifully designed guestrooms and attentive service. Welcome to the Courtyard Kingston - it's a New Stay!Guarantee required for late arrivalParking
* Neither HolidayCheck nor the provider assumes liability for the accuracy and completeness of the content displayed above. Please take note of the hotel description of the respective operator and bear in mind that the services included in an offer may differ from the catalog description presented here. We are obliged to offer solely those services available at the time of booking as shown on the booking form. © 2013 Giata
Hotel amenities
- Meeting/Banquet Facilities
- Hairdressers/Beauty salon
- Business centre
- Hotel safe
- Lift
- Air conditioning
- Free parking
- Car park
Room amenities
- Shower
- Writing bureau
- Additional childrens' bed
- Phone
- Cable TV
- Safe
- Coffee and tea
- Bathroom
- Wake up call/Alarm clock
- Restaurant
- Hotel bar
- Cafe
A choice of sports
- Fitness centre
- Tennis court
Spa offers
- Spa centre
- Whirlpool
Other hotel information
- 24 hour reception
- Babysitting/Child services
- Express check in and check out
- 24 hour security
- Car hire
- Currency exchange
- All public and private areas are no smoking zones
- Wifi
- Newspaper
- Laundry service


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Please note that as of 1st Aug 2013, Jaguar showroom in Wanchai will be temporarily moved to the following new address: G/F, Top Glory Tower, 262 Gloucester Road, Causeway Bay, Hong Kong (existing Land Rover showroom).
The most powerful production sports car Jaguar has ever built. The Jaguar XKR-SWATCH FILM >
The XKR-S in detail >
The XKR-S in photos and video >
Performance figures and technical details >


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From Wikipedia, the free encyclopedia - View original article
Mast cell | |
Mast cells | |
Details | |
Latin | mastocytus |
Identifiers | |
Code | TH H2.00.03.0.01010 |
Anatomical terminology |
Mast cell | |
Mast cells | |
Details | |
Latin | mastocytus |
Identifiers | |
Code | TH H2.00.03.0.01010 |
Anatomical terminology |
A mast cell (also known as a mastocyte or a labrocyte[1]) is derived from the myeloid stem cell and a part of the immune system that contains many granules rich in histamine and heparin. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing and defense against pathogens.[2]
The mast cell is very similar in both appearance and function to the basophil, another type of white blood cell. They differ in that mast cells are tissue resident (e.g. in mucosal tissues) while basophils are found in the blood.[3]
Mast cells were first described by Paul Ehrlich in his 1878 doctoral thesis on the basis of their unique staining characteristics and large granules. These granules also led him to the incorrect belief that they existed to nourish the surrounding tissue, so he named them Mastzellen (from German Mast, meaning "fattening", as of animals).[4][5] They are now considered to be part of the immune system.
Mast cells are very similar to basophil granulocytes (a class of white blood cells) in blood. Both are granulated cells that contain histamine and heparin, an anticoagulant. Both cells also release histamine upon binding to immunoglobulin E.[6] These similarities have led many to speculate that mast cells are basophils that have "homed in" on tissues. Furthermore they share a common precursor in bone marrow expressing the CD34 molecule. Basophils leave the bone marrow already mature, whereas the mast cell circulates in an immature form, only maturing once in a tissue site. The site an immature mast cell settles in probably determines its precise characteristics.[2] The first in vitro differentiation and growth of a pure population of mouse mast cells has been carried out using conditioned medium derived from concanavalin A-stimulated splenocytes.[7] Later, it was discovered that T cell-derived interleukin 3 was the component present in the conditioned media that was required for mast cell differentiation and growth.[8]
Mast cells in rodents are classically divided into two subtypes: connective tissue-type mast cells and mucosal mast cells. The activities of the latter are dependent on T-cells.[9]
Mast cells are present in most tissues characteristically surrounding blood vessels and nerves, and are especially prominent near the boundaries between the outside world and the internal milieu, such as the skin, mucosa of the lungs, and digestive tract, as well as the mouth, conjunctiva, and nose.[2]
Mast cells play a key role in the inflammatory process. When activated, a mast cell rapidly releases its characteristic granules and various hormonal mediators into the interstitium. Mast cells can be stimulated to degranulate by direct injury (e.g., physical or chemical [such as opioids, alcohols, and certain antibiotics such as polymyxins]), cross-linking of immunoglobulin E (IgE) receptors, or complement proteins.[2]
Mast cells express a high-affinity receptor (FcεRI) for the Fc region of IgE, the least-abundant member of the antibodies. This receptor is of such high affinity that binding of IgE molecules is in essence irreversible. As a result, mast cells are coated with IgE, which is produced by plasma cells (the antibody-producing cells of the immune system). IgE molecules, like all antibodies, are specific to one particular antigen.
In allergic reactions, mast cells remain inactive until an allergen binds to IgE already in association with the cell (see above). Other membrane activation events can either prime mast cells for subsequent degranulation or act in synergy with FcεRI signal transduction.[10] In general, allergens are proteins or polysaccharides. The allergen binds to the antigen-binding sites, which are situated on the variable regions of the IgE molecules bound to the mast cell surface. It appears that binding of two or more IgE molecules (cross-linking) is required to activate the mast cell. The clustering of the intracellular domains of the cell-bound Fc receptors, which are associated with the cross-linked IgE molecules, causes a complex sequence of reactions inside the mast cell that lead to its activation. Although this reaction is most well-understood in terms of allergy, it appears to have evolved as a defense system against intestinal worm infestations (tapeworms, etc.)[citation needed].
The molecules released into the extracellular environment include:[2]
Histamine dilates post-capillary venules, activates the endothelium, and increases blood vessel permeability. This leads to local edema (swelling), warmth, redness, and the attraction of other inflammatory cells to the site of release. It also depolarizes nerve endings (leading to itching or pain). Cutaneous signs of histamine release are the "flare and wheal"-reaction. The bump and redness immediately following a mosquito bite are a good example of this reaction, which occurs seconds after challenge of the mast cell by an allergen.[2]
The other physiologic activities of mast cells are much less-understood. Several lines of evidence suggest that mast cells may have a fairly fundamental role in innate immunity: They are capable of elaborating a vast array of important cytokines and other inflammatory mediators such as TNFa; they express multiple "pattern recognition receptors" thought to be involved in recognizing broad classes of pathogens; and mice without mast cells seem to be much more susceptible to a variety of infections.[citation needed]
Mast cell granules carry a variety of bioactive chemicals. These granules have been found to be transferred to adjacent cells of the immune system and neurons in a process of transgranulation via mast cell pseudopodia.[11]
FcεR1 is a high affinity IgE-receptor that is expressed on the surface of the mast cell. FcεR1 is a tetramer made of one alpha (α) chain, one beta (β) chain, and two identical, disulfide-linked gamma (γ) chains. The binding site for the IgE is formed by the extracellular portion of the α chain that contains two domains that are similar to Ig. One transmembrane domain contains an aspartic acid residue, and one contains a short cytoplasmic tail.[12] The β chain contains, a single immunoreceptor tyrosine-based activation motif ITAM, in the cytoplasmic region. Each γ chain has one ITAM on the cytoplasmic region. The signaling cascade from the receptor is initiated when the ITAMs of the β and γ chains are phosphorylated by tyrosine. This signal is required for the activation of mast cells.[13] Type 2 helper T cells,(Th2) and many other cell types lack the β chain, so signaling is mediated only by the γ chain. This is due to the α chain containing endoplasmic reticulum retention signals that causes the α-chains to remain degraded in the ER. The assembly of the α chain with the co-transfected β and γ chains mask the ER retention and allows the α β γ complex to be exported to the golgi apparatus to the plasma membrane in rats. In humans, only the γ complex is needed to counterbalance the α chain ER retention.[12]
Allergen-mediated FcεR1 cross-linking signals are very similar to the signaling event resulting in antigen binding to lymphocytes. The Lyn tyrosine kinase is associated with the cytoplasmic end of the FcεR1 β chain. The antigen cross-links the FcεR1 molecules, and Lyn tyrosine kinase phosphorylates the ITAMs in the FcεR1 β and γ chain in the cytoplasm. Upon phosphorylation, the Syk tyrosine kinase gets recruited to the ITAMs located on the γ chains. This causes activation of the Syk tyrosine kinase, causing it to phosphorylate.[13] Syk functions as a signal amplifying kinase activity due to the fact that it targets multiple proteins and causes their activation.[14] This antigen stimulated phosphorylation causes the activation of other proteins in the FcεR1-mediated signaling cascade.[15]
An important adaptor protein activated by the Syk phosphorylation step is the linker for activation of T cells (LAT). LAT is important because it can be modified by phosphorylation to create novel binding sites.[14] Phospholipase C (PLCγ), becomes phosphorylated once bound to LAT, and is then used to catalyze Phosphatidylinositol bisphosphate breakdown to yield inositol trisphosphate (IP3) and diacyglycerol (DAG). IP3 elevates calcium levels, and DAG activates protein kinase C (PKC). This is not the only way that PKC is made. The tyrosine kinase, Fyn, phosphorylates a Grb-2-associated binder-like protein 2 (Gab2) which binds to phosphoinositide 3-kinase which activates PKC.PKC leads to the activation of myosin light-chain phosphorylation granule movements which disassembles the actin-myosin complexes to allow granules to come into contact with the plasma membrane.[13] The mast cell granule can now fuse with the plasma membrane. Soluble N-ethylmaleimide sensitive fusion Attachment Protein Rceptor"SNARE complex mediates this process. Different SNARE proteins interact to form different complexes that catalyze fusion. Rab3 guanosine triphosphatases and Rab-associated kinases and phosphatases regulate the cell granule membrane fusion in resting mast cells.
Enzyme | Function |
Lyn tyrosine kinase | Phosphorylates the ITAMs in the FcεR1 β and γ chain in the cytoplasm. It causes Syk tyrosine kinase to get recruited to the ITAMS located on the γ chains. This causes activation of the Syk tyrosine kinase, causing it to phosphorylate |
Syk tyrosine kinase | Targets multiple proteins and causes their activation |
Phospholipase C | Catalyzes Phosphatidylinositol 4,5-bisphosphate |
Inositol trisphosphate | Elevates calcium levels |
Diacylglycerol | Activates protein kinase C |
Fyn | Phosphorylates Grb-2-associated-binder-like-protein |
Grb-2-associated-binder-like-protein | Binds to phosphoinositide 3-kinase |
Phosphoinositide 3-kinase | Activates protein kinase C |
Protein kinase C | Activates myosin light-chain phosphorylation granule movements that dissemble the actin-myosin complexes |
Rab-associated kinases and phosphatases | Regulate cell granule membrane fusion in resting mast cells |
Many forms of cutaneous and mucosal allergy are mediated in large part by mast cells; they play a central role in asthma, eczema, itch (from various causes), and allergic rhinitis and allergic conjunctivitis. Antihistamine drugs act by blocking histamine action on nerve endings. Cromoglicate-based drugs (sodium cromoglicate, nedocromil) block a calcium channel essential for mast cell degranulation, stabilizing the cell and preventing release of histamine and related mediators. Leukotriene antagonists (such as montelukast and zafirlukast) block the action of leukotriene mediators and are being used increasingly in allergic diseases.[2]
Calcium triggers the secretion of histamine from mast cells after previous exposure to sodium fluoride. The secretory process can be divided into a fluoride-activation step and a calcium-induced secretory step. It was observed that the fluoride-activation step is accompanied by an elevation of cAMP levels within the cells. The attained high levels of cAMP persist during histamine release. It was further found that catecholamines do not markedly alter the fluoride-induced histamine release. It was also confirmed that the second, but not the first, step in sodium fluoride-induced histamine secretion is inhibited by theophylline.[16] Vasodilation and increased permeability of capillaries are a result of both H1 and H2 receptor types.[17]
Stimulation of histamine activates a histamine (H2)-sensitive adenylate cyclase of oxyntic cells, and there is a rapid increase in cellular [cAMP] that is involved in activation of H+ transport and other associated changes of oxyntic cells.[18]
In anaphylaxis (a severe systemic reaction to allergens, such as nuts, bee stings, or drugs), body-wide degranulation of mast cells leads to vasodilation and, if severe, symptoms of life-threatening shock.[citation needed]
Histamine is a vasodilatory substance released during anaphylaxis.[17]
Mast cells may be implicated in the pathology associated with autoimmune, inflammatory disorders of the joints. They have been shown to be involved in the recruitment of inflammatory cells to the joints (e.g., rheumatoid arthritis) and skin (e.g., bullous pemphigoid), and this activity is dependent on antibodies and complement components.[19]
Mast cells are present within the endometrium, with increased activation and release of mediators in endometriosis.[20] In males, mast cells are present in the testes and are increased in oligo- and azoospermia, with mast cell mediators directly suppressing sperm motility in a potentially reversible manner.[20]
Mastocytosis is a rare condition featuring proliferation of mast cells. It exists in a cutaneous and systemic form, with the former being limited to the skin and the latter involving multiple organs.[2] Mast cell tumors are often seen in dogs and cats.[21]
Research into an immunological contribution to autism suggests that autism spectrum disorder (ASD) children may present with "allergic-like" problems in the absence of elevated serum IgE and chronic urticaria, suggesting non-allergic mast cell activation in response to environmental and stress triggers. This mast cell activation could contribute to brain inflammation and neurodevelopmental problems.[22]
Toluidine blue: one of the most common stains for acid mucopolysaccharides and glycoaminoglycans, components of mast cells granules.[23]
Surface markers: cell surface markers of mast cells were discussed in detail by Heneberg,[24] claiming that mast cells may be inadverently included in the stem or progenitor cell isolates, since part of them is positive for the CD34 antigen. The classical mast cell markers include the high-affinity IgE receptor, CD117 (c-Kit), and CD203c (for most of the mast cell populations). Expression of some molecules may change in course of the mast cell activation.[25]


text:
Guest House Brazil-Africa Reviews
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Reviews & Ratings Explained
The rating percentage is calculated from customers who booked within the last 12 months.
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The guest house was in a great location with 3 lovely ladies looking after you. It was really nice to have a shower and basin in the room to make you feel like it was more private. We arrived at 9:00 and checked in straight away which was so nice after we'd been travelling for 17hours straight. A great stay
- Novice Nomad
- Anonymous
- Australia
- Couple, 18-24
- (1 review)
strongly recommend, nice host, good location, clean room, yammy breakfast!!!!!!!! everything is excellent 强烈推荐这家,老板超级好,早上还有奶奶给做早饭,我们一开始不知道有早饭,正准备出门,奶奶把我们叫回来给我们泡牛奶,做布丁
- Novice Nomad
- Anonymous
- China
- Female, 25-30
- (2 reviews)
The ladies that run this hostel are really friendly and helpful. Has great location in centre of Lisbon. Atmosphere was a bit lacking when we were there although every where seemed quiet around town so may have been time of year. Not a party hostel but that's not what we wanted
- Avid Traveller
- Anonymous
- New Zealand
- Couple, 25-30
- (17 reviews)
A great place to stay. The staff was very nice and made a home-feeling and velcomming atmosphere. The breakfast was with toastet bread, chorizo, ham and fresh fruit. Just around the corner was cozy cafe's and good restaurants. Really a great stay. The only negative thing, was, that the room window was facing out to a noisy street. So we can recommend to get a room closest to the reception, where the windows are facing a quiet street.
- Novice Nomad
- bette_m73988
- Denmark
- Couple, 31-40
- (3 reviews)
A wonderful place to stay and enjoy Lisbon. Thanks to the very friendly and helpful staff.
- Novice Nomad
- Anonymous
- Poland
- Female, 31-40
- (1 review)
Charming BnB in the centre of Lisbon run by three exceptionally friendly and hospitable ladies who will do their best to make you feel at home.
- Novice Nomad
- judithcorcoran4916
- Ireland
- Female, 31-40
- (1 review)
My mother and I were very happy with the Guest House Brazil-Africa. Especially the ladies there were really nice and helpful. They speak English, one speaks Spanish and the brazilian lady German. Breakfast was really rich, it's on one big table and really familiar. Location is great, really close to the cathedral. We had a 3-bed room with own shower and washbasin but the toilets were on the corridor really near. The familiar atmosphere was the best!
- Novice Nomad
- Anonymous
- Germany
- Female, 18-24
- (4 reviews)


text:
Robert Fisk is nearly beaten to death, plus 5 more snippets from a busy week of political and military activity.
Fawning Over Barghouti
The violent Tanzim leader is portrayed by Associated Press as a jovial family man.
The Atlantic Monthly
Exposing the intentional crash of EgyptAir flight 990, and a view of modern Israel where ordinary life defeats terrorism.
Teen Settler
As Jews are gunned down in the streets of Jerusalem, Associated Press labels them
Assassination of a Patriot
Is the Palestinian assassination of a democratically-elected tourism minister, at all the same as Israel targeting a terrorist mastermind?
Focus On Terror
Palestinians exhibit a grisly re-enactment of the Sbarro suicide bombing, and the Sacramento Bee attacks Israel's anti-terror stance.
CNN Finally Gets the Message
A double-success for HonestReporting members: CNN stops referring to Gilo as a settlement, and a veteran Israel-basher gives credit to HonestReporting.com.
Stepping Out of the Ring
A Jewish reporter who lives in Ramallah states her case in The New York Times. As expected, the result is not pretty.
Award to Charles Krauthammer
Charles Krauthammer's journalism is consistently accurate, incisive and enlightening. Even more important is his courage to state the truth.
How I Spent My Summer Vacation
Teams of supposed American peacemakers spend the summer living amongst Palestinians, and then file op-ed reports on the oppressive Israelis.


text:
Tuesday, January 26
American Airlines Center
Attendance: 19,799
Dallas, TX (Sports Network) - Carlos Delfino's driving jump shot didn't fall in the final seconds, and Dallas used Dirk Nowitzki's 28-point, eight-rebound effort to escape with a 108-107 victory over Milwaukee.
"Well, we had a couple of options depending on whether they switched or not. Carlos came to the top [of the lane], was pretty much open, and (Erick) Dampier came out on him and I felt like he did the right thing, he tried to put it on the floor and go by him. He wasn't able to get all the way by him, but that's the right thought in that situation, to try and drive the ball against the big guy," Milwaukee head coach Scott Skiles explained.
Jason Terry added 21 points and Jason Kidd notched a double-double with 11 points and 12 assists for the Mavericks, who were coming off a 50-point rout of the New York Knicks on Sunday.
"It's exciting but it gets difficult. Milwaukee is a persistent team," Dallas head coach Rick Carlisle surmised.
Andrew Bogut nearly single-handedly kept the Bucks in the game with 32 points, on a remarkable 13-of-14 shooting, to go with nine rebounds. Delfino added 22 points, six rebounds and five assists, while Brandon Jennings chipped in with 12 points and seven assists. Milwaukee has split its last four contests.
Kidd's trey gave Dallas a 108-101 edge with just under two minutes left, but Milwaukee rallied behind a pair of Delfino threes, the latter coming with 27.8 seconds to play.
Nowitzki then turned the basketball over, giving Milwaukee one last chance, but Delfino missed in the closing seconds.
Dallas held a 28-27 lead after one stanza then tallied nine of the second period's first 12 points to take a 37-30 edge on Drew Gooden's slam. The edge grew to 44-36 on Gooden's reverse layup, and despite cutting the deficit to three on several occasions, the margin stood at six, 59-53 at the half.
The Bucks got within one at 73-72 on Jennings' three-point play with 3:17 to play in the third stanza, but Nowitzki poured in the next six points to seize a seven-point edge. Dallas led 83-77 at the end of the third quarter.
Milwaukee tied the game at 93-93 on a Luke Ridnour pull-up jumper with 6:43 to play. Ridnour scored 11 points on 4-of-11 shooting with six assists. Dallas managed eight of the next 10 points with Terry's jumper extending the lead to 101-95.
Bogut's layup brought the Bucks within 101-99 with 3:51 to play, but Dallas extended the margin back out to seven at 108-101 before Delfino almost pulled out the late heroics.
Monty McCutchen
Jason Phillips
Scott Wall


text: #1526: Heimdal installation -----------------------------------+---------------------------------------- Reporter: LFS-User at mcmurchy.com | Owner: randy at linuxfromscratch.org Type: defect | Status: closed Priority: low | Milestone: future Component: BOOK | Version: SVN Severity: major | Resolution: fixed Keywords: | -----------------------------------+---------------------------------------- Changes (by randy at linuxfromscratch.org): * status: assigned => closed * resolution: => fixed Comment: Testing has shown that indeed some packages need to access the E2fsprogs original ss.h header file. So, the Heimdal instructions have been changed to restore the E2fsprogs files after the installation. Testing also has shown that there is no problems with the Heimdal installation (linking to it or otherwise) using the E2fsprogs files. Closing the ticket for now as there is really nothing else that can be done. Perhaps in the Heimdal-0.8 release, things will be different. -- Ticket URL: <http://wiki.linuxfromscratch.org/blfs/ticket/1526#comment:9> BLFS Trac <http://wiki.linuxfromscratch.org/blfs> Beyond Linux From Scratch