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Asustek Computer's Eee PC 1004DN is the first in the Eee PC range to feature a super-multi optical disc drive (ODD), enabling users to read and write optical discs for data back-ups.
The netbook also features a power-efficient Express Card slot to provide expansion capabilities, along with plug-and-play compatibility and auto-configuration access. Asustek's Super Hybrid Engine (SHE) technology provides extended battery life.
The netbook is equipped with a 10-inch LCD display that supports 720p high definition playback and an Intel Atom N280 processor paired with GN40 chipsets.
- Wireless broadband developments in Southeast Asia markets
As of 2013, the 10 ASEAN nations had a total of over 700 million mobile subscriptions, with the CAGR from 2003-2013 reaching 24%. This Digitimes Research Special Report analyzes the various mobile broadband markets in ASEAN and looks at the respective trends in 4G LTE development for those markets.
- Greater China touch panel shipment forecast through 2015
This Special Report provides forecasts through 2015 for Greater China touch panel shipments with breakdowns based on technology (glass, film, resistive), application (smartphone, NB and tablet) and by firm.
- 2014 global tablet demand forecast
This report analyzes the main players, their strategies and shipments forecasts for 2014, as well as other factors contributing to either growth or decline in various segments within the tablet market, with a particular focus on Apple, Google, Samsung, and Microsoft, along with whitebox vendors.


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Neymar will not be taking part in this season's first match against Elche. Even though the player has recovered quite well from the grade I sprain to his left ankle, he won't be making his 2014-15 season debut today.
The Brazilian ace will be forced to see the match from the sidelines, along with Ter Stegen, Vermaelen and Adriano – all injured, and Pique and Luis Suarez - both suspended.
The manager has also decided not to play Song, while Pedro has been given the green light to play by the club's medical team and is on Luis Enrique's list of 18, as are Sandro and Munir from Barcelona B. The men chosen to kick of Barca's season are Bravo, Masip, Montoya, Bartra, Alves, Mathieu, Mascherano, Alba, Sergio, Xavi, Iniesta, Rakitic, Sergi Roberto, Rafinha, Pedro, Munir, Messi and Sandro.

subset: commoncrawl


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Sponsored by: Brakes Plus
Sep 30, 2013 3:34 PM by Alyse Rzemek
DENVER (AP) - Authorities say a black bear was killed when it was hit by a car on Interstate 25 near the Colorado-Wyoming border.
Colorado State Patrol says the small bear was hit just south of Wellington at about 5:30 a.m. Monday.
The car sustained minor damage, and the driver was not injured.
2 months ago


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Introducing leggings. You'll never run out of inspiration.
Pocket-sized art with more uses than you can wave a Bic at. Birthdays, thanks yous, Valentines or even Wednesdays, there's always an occasion for a stunning card. From promotional weapon to distant friend-contactor, our cards are more versatile than Optimus Prime.
Cards are designed to suit the most common image ratio of 3:2, but any image size can be printed—we just leave a white border.
enough said…(uploaded an art version for greeting card purchases)
happy, funny, christmas, birthday, weird, strange, valentine, easter, holidays, anti, everything, sarcasm, sarcastic
cool idea for the ones who couldn't care less…
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Lyrics Depot | |
Lyrics » Clannad Lyrics » Jug of Brown Ale, The Lyrics |
Lyrics Depot is your source of lyrics to Jug of Brown Ale, The by Clannad. Please check back for more Clannad lyrics. |
Jug of Brown Ale, The LyricsArtist: ClannadAlbum: Dulaman
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Product #: EMC5605015_TQA Blizzard (Web Organizers) (Resource Book Only) eBookGrade 2|Grade 3|Grade 4Ships Free!
Please Note: This ebook is a digital download, NOT a physical product. After purchase, you will be provided a one time link to download ebooks to your computer. Orders paid by PayPal require up to 8 business hours to verify payment and release electronic media. For immediate downloads, payment with credit card is required.
This writing unit provides four activity pages in which students use web organizers to write paragraphs with topic sentences and supporting details about dangerous weather events (blizzard, tornado, hurricane, tsunami). Students also use appropriate writing conventions. (Find other units by searching 'Organize/Write 2.')
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Yossi Benayoun named in Israel squad as Chelsea midfielder makes comeback from achilles injury
Yossi Benayoun has been named in Israel's squad for their European Championship qualifiers against Latvia and Georgia at the end of the month. Chelsea midfielder Benayoun, who captains Israel, has been out since September with an achilles problem but is due to resume full training on Friday. Back in training: Benayoun Swansea want Chelsea striker Fabio Borini on loan to power promotion pushAll the latest Chelsea news, features and opinion Explore more:Places: Israel, Latvia
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For moms who love to write!
Members: 452
Latest Activity: on Friday
Started by Cynthia Tolbert-Wilson Mar 30, 2013. 0 Replies 0 Likes
Started by The Sexy Single Mommy Dec 18, 2012. 0 Replies 1 Like
* Books for Kids - Manuscript Critiques
* HOOK Kids on Reading
Half way through this month's site exchange, hop on over! http://callemami.com/2011/11/november-blog-hop/ Drop by and add your site for your chance to be featured in an article. I'll link back!
Two decades of journalling:
To celebrate soon-to-be-released, The Lion, the Lamb, the Hunted, author Andrew E. Kaufman's #1 bestseller, While the Savage Sleeps, is being offered for just .99 on Amazon Kindle. Limited time only! I highly recommend this book. It shot to #1 on 4 bestseller lists when it came out.
http://www.amazon.com/While-th e-Savage-Sleeps-ebook/dp/B003RCJUCM/ref=sr_1_1?ie=UTF8&m=AG56TW...
HOOK KIDS on READING
is celebrating Picture Book Month by offering
a list of wonderful new picture books titles.
LINKS to authors and how to BUY are included.
Give BOOKS to the children in YOUR life this Holiday Season.
Books for Kids - Manuscript Critiques
Congratulations to T.E. MacArthur on the release of her Historical Steampunk "The Volcano Lady: A Fearful Storm Brewing". Through Novel Launch (interactive book launch service) I'm helping give away some copies. One of the easiest ways to be entered for the winner's choice of ebook or paperback can be found by checking out the book's page over on the Novel Launch website. Make sure to scroll down to the bottom and leave a comment telling us one thing about the author and one thing about the book: http://novellaunch.weebly.com/the-volcano-lady-by-t-e-macarthur.html
Hi~ I love to write.....and be inspired by others writing. I always comment and/or follow, so come on over and check out my latest modeling memoir.
Hi writing moms, please come read this important post!
My blogger spotlight this week is Mothering Many Feet. Come read her story about homebirth loss.
NaNoWriMo writing love. Leave a comment so I can follow you and see what your writing these days! Would specially love more NaNo friends!
Welcome welilwimsy, this is a great place to meet other writers. Networking, and picking the brains of established writers is a great way to learn the writing ropes.
Books for Kids - Manuscript Critiques
Virtual School Visits
A new study says using Facebook too much causes envy and depression. Do you agree?
Join the conversation to win our daily prize. And, see Friday's winner!
Mom Bloggers for Social Good is a global coalition of 2000+ mom bloggers who currently span over twenty countries and who care about spreading the good news about the amazing work non-profit organizations and NGOs are doing around the world. Want to make a difference? Please join us!
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The following links will download a PDF from the University Policy Register.
You will require Adobe Acrobat Reader to view these documents.
Academic dress (108KB PDF)
Appointment and roles of Pro-Deans, Deputy Deans, Associate Deans and Sub-Deans (31KB PDF)
Appointment of a Deputy Vice-Chancellor or Pro-Vice-Chancellor: selection committee (33KB PDF)
Appointment of Vice-Chancellor (29KB PDF)
Charter of academic freedom (29KB PDF)
- Buildings and estates
- Chair appointments
- Finance and audit
- Human resources
- Investment and commercialisation
- Nomination and appointments
- Safety and risk management
Election of Principal Officers of the Senate, and of committees of the Senate and of the Fellow referred to in Section 9(1) (c) of the Act (37KB PDF)
Delegations of authority: academic functions (83KB PDF)
Governance of Faculties, Colleges, College Boards, Boards of Studies, Departments, Schools and Committees (110KB PDF)
Guidelines concerning commercial activities Section 26B of The University Of Sydney Act 1989 (58KB PDF)
Postgraduate: degree of Doctor of Philosophy (90KB PDF)
Resolutions of Senate: restrictions upon re-enrolment (33KB PDF)
Selection of candidates for Honorary awards policy (41KB PDF)
Sports Unions, SRC and Faculty Societies, SUPRA, Union, Cumberland Student Guild and SASCA (33KB PDF)
University Governance (as amended) (49KB PDF)


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Union Plus Scholarship Deadline Is Jan. 31
Time is running out to apply for the 2015 Union Plus college scholarship program for union members and their children. Applications must be submitted by noon Eastern time on Jan. 31. Since 1992, the program has awarded more than $3.6 million to students of more than 2,400 working families. The awards will range from $500 to $4,000 and are for study beginning in the fall each year. Students may re-apply each year.


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Flame of Faith to host turkey dinner
Flame of Faith United Methodist Church, 1222 6th St E, West Fargo, will be the site for its 15th annual Turkey Dinner served Saturday, Oct. 22, from 4 to 7 p.m. The menu will feature turkey and dressing, mashed potatoes and gravy, corn, cranberries and dessert.
Cost is $9 for adults, $4 for children 12 years old and under, and children under 5 eat free.
Bazaar items, crafts and baked goods will also be on sale.
Are you a newspaper subscriber but you don't have a Digital Access account yet? https://secure.forumcomm.com/?publisher_ID=40&event=subscriber/lookup.
You will need your subscription account number and phone number. Not sure if you have an account? Email us at firstname.lastname@example.com and we can help you.


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The Friends of the Archives of the City of Kingsport will host their Annual Meeting and Betty Gibson Memorial Lecture on Tuesday, October 29, 2013. The meeting is held in conjunction with American Archives Month and welcomes guest speaker Pete Lodal, whose topic will be "The Eastman Explosion." The event is free and open to … Continue reading
Tagged with Tennessee Eastman Explosion 1960 …
Tennessee Eastman Explosion,1960
Tomorrow marks the 51st anniversary of the Eastman Explosion. The explosion occurred on October 4, 1960. For more information and photos please revisit the posts on the blog from last year. https://kingsportarchives.wordpress.com/2010/10/02/tennessee-eastman-explosion-october-4-1960/ https://kingsportarchives.wordpress.com/2010/10/04/the-day-kingsport-wept-eastman-explosion-october-4-1960/ https://kingsportarchives.wordpress.com/2010/10/04/eastman-explosion-1960-list-of-deceased/
Eastman Explosion 1960-list of deceased
Below is a listing of men who died as a result of the Eastman Explosion compiled by Pete Dykes in his booklet, "The Day the Plant Exploded," date unknown. *Bernard C. Arnold- Employed at Eastman for 17 years. Worked in the Acid Division. *J.D. Byington, 50-With Eastman for 23 years in the S & M … Continue reading
The Day Kingsport Wept-Eastman Explosion October 4, 1960
"Earth shattering events have a way of burning themselves into the consciousness. Most people, if they're old enough can recall exactly what they were doing when they learned that the Japanese bombed Pearl Harbor, and that President Kennedy had been shot. For Kingsport, it's that way with the Eastman Explosion." Mary Kiss-Kingsport Times- News Staff … Continue reading
Tennessee Eastman Explosion, October 4, 1960
Where were you on October 4, 1960-the day of the Eastman Explosion??? ***Please remember the photographic images on this site are the property of the Archives of the City of Kingsport and are governed by U.S. and International copyright laws. Please contact the archives for permission to use images or request reproductions*** Fifty years ago … Continue reading


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A friend in preparation for Mardi Gras Parade Sydney March 2007
I love the tones here Robert, really brings out, with all due respect, the 'artificialness' . Love the perspective and I love the pout. Work it baby!
Love this high key look, Robert. What gorgeous eyes he has!!!
that's it- I'm going out righ tnow to buy some fake eyelashes. I love the slight pout.
great composition and tones.
Thanks everyone. False eyelashes bring out extraordinary things in eys. Jo, falsies and pouting – all a good drag queen needs really..oh and a bit of attitude helps too :)) Work it indeed!
Great image – just such wonderful tones!
All parts in his face are so sharp and beautiful and this light blue tone makes his face so mysterious but soft too. Nice image Robert.
Very cool indeed Robert! love it!
Love it Robert
Glad you like this image RB's. Thanks Penny – nice to meet you. Mayuphoto, I liked the blue tones too – tried it in pink and B&W (both good) but this seemed to be the right choice .)


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Confine the mouse cursor into a screen or window to fix certain games.Windows Version 2.6 ... Added: 07/15/13Total Downloads21,736Last Week45
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An interactive energy oversight application for your utiliVisor buildings.iOS Version 1.2.33 ... Added: 02/09/13Total Downloads3Last Week3
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From Wikipedia, the free encyclopedia - View original article
Monoclonal antibody | |
Type | Whole antibody |
Source | Humanized (from mouse) |
Target | Complement protein C5 |
Clinical data | |
Trade names | Soliris |
AHFS/Drugs.com | monograph |
Licence data | EMA:Link, US FDA:link |
Pregnancy cat. |
Legal status | |
Routes | Intravenous infusion |
Pharmacokinetic data | |
Half-life | 8 to 15 days (mean 11 days) |
Identifiers | |
CAS number | 219685-50-4 |
ATC code | L04AA25 |
DrugBank | DB01257 |
ChEMBL | CHEMBL1201828 |
Chemical data | |
Formula | ? |
Mol. mass | 148 kDa |
(what is this?) (verify) |
This article needs additional citations for verification. (April 2013) |
Monoclonal antibody | |
Type | Whole antibody |
Source | Humanized (from mouse) |
Target | Complement protein C5 |
Clinical data | |
Trade names | Soliris |
AHFS/Drugs.com | monograph |
Licence data | EMA:Link, US FDA:link |
Pregnancy cat. |
Legal status | |
Routes | Intravenous infusion |
Pharmacokinetic data | |
Half-life | 8 to 15 days (mean 11 days) |
Identifiers | |
CAS number | 219685-50-4 |
ATC code | L04AA25 |
DrugBank | DB01257 |
ChEMBL | CHEMBL1201828 |
Chemical data | |
Formula | ? |
Mol. mass | 148 kDa |
(what is this?) (verify) |
Eculizumab (INN and USAN; trade name Soliris) is a humanized monoclonal antibody that is a first-in-class terminal complement inhibitor and the first therapy approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare, progressive, and sometimes life-threatening disease characterized by excessive destruction of red blood cells (hemolysis) and excessive blood clotting.[1] Eculizumab also is the first agent approved for the treatment of atypical hemolytic uremic syndrome (aHUS), an ultra-rare genetic disease that causes abnormal blood clots to form in small blood vessels throughout the body, leading to kidney failure, damage to other vital organs and premature death.[2][3] It costs approximately £245,700 for ongoing treatment.[4] The extraordinarily high cost of the drug is a source of controversy.[5]
In clinical trials in patients with PNH, eculizumab was associated with reductions in chronic hemolysis, thromboembolic events, and transfusion requirements, as well as improvements in PNH symptoms, quality of life, and survival.[1][6][7][8] Clinical trials in patients with aHUS demonstrated inhibition of thrombotic microangiopathy (TMA),[9] the formation of blood clots in small blood vessels throughout the body,[1][3][6] including normalization of platelets and lactate dehydrogenase (LDH), as well as maintenance or improvement in renal function.[9]
Eculizumab was developed by Alexion Pharmaceuticals and is manufactured by Alexion. It was approved by the United States Food and Drug Administration (FDA) on March 16, 2007 for the treatment of PNH, and on September 23, 2011 for the treatment of aHUS. It was approved by the European Medicines Agency for the treatment of PNH on June 20, 2007, and on November 24, 2011 for the treatment of aHUS. Eculizumab is currently being investigated as a potential treatment for other severe, ultra-rare disorders.
Historically, 35% of people with paroxysmal nocturnal hemoglobinuria treated with the best available care (e.g., anticoagulation therapy, transfusions), died within 5 years of diagnosis.[10] Thromboembolism (TE) is the leading cause of death in PNH patients, accounting for 40% to 67% of PNH-related mortality.[11][12] Patients with PNH are 62 times more likely to have a venous thromboembolism than the general population, which is higher than any other hyper-coaguable disease.[13][14] Both venous and arterial thromboembolism can occur in patients with PNH.[15] Although deep vein thrombosis and pulmonary embolism are the most common clinical presentations,[11] thrombosis in atypical sites (including Budd-Chiari, renal, and dermal thrombosis) is more common among PNH patients than in the general population. In a national registry, 39% of TEs in patients with PNH occurred in arterial sites.[16] For patients who experience TE and survive, the risk of subsequent TEs is increased,[11] and the risk of death increases 5- to 15-fold for PNH patients with no previous TE.[16] Sixty percent of patients with PNH have evidence of undiagnosed thrombosis.[13]
Data from three independent clinical studies—a Phase II pilot study,[6] the Phase III TRIUMPH study,[1] and the Phase III SHEPHERD study[7]—demonstrated a greater than 90% reduction in thromboembolic events, the most serious complication of PNH and a major cause of death in this disease. Many PNH patients in clinical trials derived a benefit from eculizumab therapy; many benefits occurred rapidly, while others showed improvement over time.[9]
Eculizumab protects blood cells against immune destruction by inhibiting the complement system. In the TRIUMPH study, a double-blind, randomized, placebo-controlled, Phase III trial involving 87 patients, eculizumab was associated with an 86% reduction in intravascular hemolysis, as measured by LDH reduction, as well as a 73% reduction in transfusions across all subgroups. There was a rapid and meaningful improvement in fatigue and quality of life for the treated patients.[1]
Historically, 33-40% of patients with aHUS died or progressed to ESRD with the first clinical manifestation of the disease.[2][3] Moreover, 65% of all patients with aHUS will die, require kidney dialysis, or have permanent renal damage within one year of diagnosis despite administration of plasma exchange or plasma infusion (PE/PI).[3] Prior to the availability of eculizumab, management of aHUS did not specifically target chronic uncontrolled complement activation, the underlying cause of systemic TMA in aHUS. Not only is PE/PI ineffective in arresting platelet activation and systemic TMA, but it also causes poor outcomes and carries the risk of serious – and sometimes fatal – complications.[17][18] Even those patients who survive the first clinical manifestations of aHUS continue to experience TMA and remain at risk of progressive failure of vital organs or sudden death.[3]
Eculizumab has been shown to inhibit terminal complement activity in children and adults with aHUS, and to eliminate the need for PE/PI and new dialysis.[9] The efficacy and safety of eculizumab in aHUS have been studied in two prospective studies, one involving 17 patients with progressing TMA (median age 28 years, range 17-68) who were resistant to or intolerant of PE/PI (Study 1)[21], and the other involving 20 patients with long duration of aHUS (median age 28 years, range 13–63; median duration from diagnosis of aHUS to screening 48 months) who were receiving chronic PE/PI (Study 2).[19] TMA-related endpoints in these trials included the following:[9][19][20]
In Study 1, eculizumab inhibited complement-mediated TMA activity in all 17 patients through 26 weeks. Efficacy findings included a significant and sustained increase in platelet count through Week 26. Thirteen patients (76%) achieved hematologic normalization, and 15 patients (88%) achieved TMA event-free status. Renal function, as measured by eGFR, improved in nine patients (53%); the median duration of eGFR improvement was 251 days. Additionally, four of the five patients requiring dialysis at study entry were able to discontinue dialysis for the duration of eculizumab treatment. Quality of life (QoL) was significantly improved, with 80% of patients achieving a clinically meaningful change through Week 26; this increased to 87% through 1 year.[9][20]
Similar results were reported in Study 2, in which 16 patients (80%) achieved TMA event-free status and 18 (90%) achieved hematologic normalization. All patients discontinued PE/PI and no new dialysis was required. Eculizumab was associated with mean increases in platelet count and eGFR from baseline to 26 weeks. QoL was also improved, with 8 of 11 (73%) evaluable patients exceeding the clinically meaningful threshold through a median duration of 62 weeks.[9][19]
After completing the initial 26-week treatment period, most patients in each of the prospective studies continued to receive eculizumab by enrolling in an extension study. Two-year follow-up data from the extension studies suggest that eculizumab provides sustained inhibition of complement-mediated TMA and significant, continuous, time-dependent improvement in renal function. In the extension to Study 1, in which 13 patients were treated for a median duration of 100 weeks, chronic eculizumab treatment resulted in a continued increase in platelet counts and greater percentages of patients achieving key renal endpoints compared to those completing 26 weeks of therapy. Additionally, at a median duration of almost 2 years, all patients receiving chronic eculizumab therapy remain alive.[21] In the extension to Study 2, in which 20 patients were treated for a median duration of 114 weeks, 19 (95%) achieved TMA event-free status, and the percentages of patients reaching the key renal endpoints were also higher than at Week 26. No patient on chronic eculizumab therapy in the extension to Study 2 required PE/PI or progressed to ESRD or dialysis.[22]
Efficacy results from a single-arm retrospective study, in which 30 patients (including 19 pediatric patients aged 2 months to 17 years) were treated for a median of 16 weeks, were generally consistent with those from the two prospective studies. Among the pediatric patients, eculizumab reduced signs of TMA activity, as shown by an increase in mean platelet counts from baseline. Seventeen (89%) pediatric patients achieved platelet count normalization, 8 (42%) attained hematologic normalization, 8 (42%) had a complete TMA response, and 9 (47%) experienced improvement in eGFR from baseline. Four of 8 pediatric patients (50%) discontinued dialysis during the study period, and none required new dialysis while on eculizumab therapy.[9]
In addition to the above single-arm studies, there are dozens of published case reports of the use of eculizumab in patients with aHUS, including several reporting complete or partial recovery of renal function with no need for subsequent kidney replacement therapy.[23] One pediatric patient, who was initially diagnosed shortly after birth and experienced four episodes of clinical TMA complications within 18 months following discontinuation of PE/PI, has been treated with eculizumab for 36 months as of December 2011, with no evidence of aHUS clinical manifestation, adverse events, or serious infections; this is the longest reported event-free period in the clinical literature.[24]
In PNH clinical trials, the most frequently reported adverse events (AEs) were headache (44%), nasopharyngitis (23%), back pain (19%), nausea (16%), fatigue (12%), and cough (12%).[9] In two prospective clinical trials in aHUS, the most commonly reported AEs were hypertension (35%), upper respiratory infection (35%), diarrhea (32%), headache (30%), anemia (24%), vomiting (22%), and nausea (19%). Twenty of 37 patients (54%) in the aHUS trials experienced a serious adverse event (SAE); the most commonly reported SAEs were hypertension (16%) and infections (14%).[9]
Eculizumab inhibits terminal complement activation and therefore makes patients vulnerable to infection with encapsulated organisms. Life-threatening and fatal meningococcal infections have occurred in patients who received eculizumab.[9] Due to the increased risk of meningococcal infections, meningococcal vaccination is recommended at least 2 weeks prior to receiving eculizumab, unless the risks of delaying eculizumab therapy outweigh the risk of developing a meningococcal infection, in which case the meningococcal vaccine should be administered as soon as possible.[9] However, current meningococcal vaccines do not protect against strains of meningococcus with a serogroup B antigen,[25] and thus may not be sufficient to protect patients.
Eculizumab treatment is recommended to continue for the patient's lifetime, unless discontinuation of therapy is clinically indicated.[26] In aHUS clinical studies, 18 patients (five in the prospective studies) discontinued eculizumab treatment; TMA complications occurred following a missed dose in five patients, and eculizumab was reinstated in four of these five patients.
Eculizumab is a recombinant humanized monoclonal IgG2/4 antibody[27] that selectively targets and inhibits the terminal portion of the complement cascade. The complement system is a branch of the body's immune system that destroys and removes foreign particles. When complement proteins are activated and bind to the surfaces of foreign particles, it triggers a cascade by which one complement protein induces the activation of the next protein in the sequence. The complement proteins then create holes or pores in the invading organisms, leading to their destruction. While complement plays an important role in protecting the body from foreign organisms, it can also destroy healthy cells and tissue.
Eculizumab specifically binds to the terminal Complement component 5, or C5, which acts at a late stage in the complement cascade. When activated, C5 is involved in activating host cells, thereby attracting pro-inflammatory immune cells, while also destroying cells by triggering pore formation. By inhibiting the complement cascade at this point, the normal, disease-preventing functions of proximal complement system are largely preserved, while the properties of C5 that promote inflammation and cell destruction are impeded.[28]
Eculizumab inhibits the cleavage of C5 to C5a (a potent anaphylatoxin with prothrombotic and proinflammatory properties) and C5b by the C5 convertase, which prevents the generation of the terminal complement complex C5b-9 (which also has prothrombotic and proinflammatory effects). Both C5a and C5b-9 cause the terminal complement-mediated events that are characteristic of PNH and aHUS.[28]
An acquired genetic mutation in patients with PNH leads to the generation from bone marrow of abnormal cell lines (known as PNH cells) that are deficient in protective complement inhibitors on the cell surface. PNH red blood cells undergo lysis due to constant attack by the body's complement (immune) system. Eculizumab inhibits terminal complement-mediated chronic hemolysis in people with (PNH).[28]
Eculizumab inhibits complement-mediated thrombotic microangiopathy (TMA) in patients with aHUS, a disease in which a deficiency of natural complement regulatory factors leads to chronic uncontrolled complement activation. This results in platelet activation, endothelial cell damage, and systemic, persistent TMA.[9]
Eculizumab is a humanized monoclonal antibody against the complement protein C5. It is an immunoglobulin G-kappa (IgGκ) consisting of human constant regions and murine complementarity-determining regions grafted onto human framework light and heavy chain variable regions. The compound contains two 448-amino acid heavy chains and two 214-amino acid light chains, and has a molecular weight of approximately 148 kilodaltons (kDa).[29]
The metabolism of eculizumab is thought to occur via lysosomal enzymes that cleave the antibody to generate small peptides and amino acids. The volume of distribution of eculizumab in humans approximates that of plasma.[29]
There are case reports of eculizumab being used to treat Shiga-toxin-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS),[30] such as occurred during the May 2011 outbreak of enteroaggretative E. coli infections in Germany (the STEC-HUS commonly seen in North America is of the enterohemorrhagic type). Eculizumab was given to block complement activation, which plays a role in the pathogenesis of both STEC-HUS and aHUS. Specifically, Shiga-toxin has been shown to trigger uncontrolled complement activity through direct activation of the alternative complement pathway[31][32] as well as by binding to and inactivating the regulatory protein complement factor H.[33]
Preliminary results from a Mayo Clinic research study show that eculizumab prevents acute humoral rejection (AHR, also known as antibody-mediated rejection (AMR)) of kidney allografts by inhibiting activation of the complement system by antigen-antibody complexes.[34] Specifically, eculizumab treatment led to a significant decrease in the incidence of early AHR, compared to a historical control group that received no eculizumab. Eculizumab also reportedly maintained stable allograft function and simplified the management of kidney transplant patients by decreasing the need for post-transplant plasma exchange and splenectomy.[35] Researchers at Johns Hopkins University have also reported a case in which eculizumab was combined with plasmapheresis and intravenous immunoglobulin to salvage a kidney undergoing severe AMR. In this case, eculizumab, by inhibiting the cleavage of complement protein C5 to the C5a and C5b receptors, was associated with a marked decrease in membrane attack complex (C5b-9) deposition in the kidney.[36]
Eculizumab has been shown to produce a clinically meaningful benefit in patients with severe and refractory generalized myasthenia gravis, a rare neurological disorder caused by uncontrolled complement activation resulting from auto-antibodies that recognize a specific target in the nerve-muscle junction.[37] In a Phase II study involving 14 patients, eculizumab was superior to placebo in improving disease severity scores, and the improvement was achieved more rapidly with eculizumab than with placebo.[38]
An open-label study is investigating the effects of eculizumab in patients with neuromyelitis optica, a complement-mediated inflammatory disease of the brain tissues that can potentiate immune attack on the optic nerves (leading to optic neuritis), spinal cord (causing transverse myelitis), and brain.[39]
Membranoproliferative glomerulonephritis (MPGN, previously known as mesangiocapillary glomerulonephritis) is an uncommon cause of chronic nephritis that primarily affects children but can occur at any age. Its clinical presentation and course can range from benign and slowly progressive to rapidly progressive. Patients may thus present with hematuria (blood in the urine), proteinuria (excess protein in the urine), renal impairment, and hypertension. MPGN frequently progresses to end-stage renal disease (ESRD) and disease recurrence following kidney transplantation.[40] Some cases of the disease are thought to result from complement dysregulation.[40][41][42][43] Canadian researchers have reported a case in which eculizumab produced "a dramatic response" in a 16-year-old girl with MPGN, as evidenced by amelioration of neurologic complications, normalization of kidney function, and improvements in thrombocytopenia, anemia, proteinuria, and hypoalbuminemia.[42][43]
Dense-deposit disease (DDD), previously considered a subtype of MPGN (sometimes known as MPGN II), is characterized by dense deposits of immunoglobulins, complement factors, or both in the basement membrane of the glomerulus.[40] DDD frequently progresses to ESRD and disease recurrence after kidney transplantation.[44] In a March 22, 2012 letter to the New England Journal of Medicine, a group of Italian researchers reported a case involving an 11-year-old girl with DDD who was treated with eculizumab, which led to normalization of serum total protein and albumin, decreased creatinine, and decline of proteinuria to below the nephrotic range.[45] The same issue of the New England Journal of Medicine also featured a letter from another group of Italian researchers, who reported a case in which a 17-year-old patient with DDD experienced improvements in proteinuria, plasma protein levels, and renal function, along with reductions in the size of dense deposits, after treatment with eculizumab. After treatment was interrupted after 18 months, proteinuria rapidly increased; eculizumab therapy was resumed 6 months later, and was associated with a reduction in proteinuria.[44] In a Phase I trial involving three patients with DDD and three with C3 glomerulonephritis who were treated with eculizumab every other week for 1 year, two patients showed significantly reduced serum creatinine, one achieved a marked reduction in proteinuria, and one had stable laboratory parameters but histopathologic improvements. The investigators surmised that pre-treatment elevation of serum membrane attack complex may predict response to eculizumab in DDD and C3 glomerulonephritis, both of which comprise C3 glomerulopathy.[46]
There are also reports of eculizumab being used to treat cold agglutinin disease. In one patient case report, eculizumab led to a sustained reduction of hemolysis, disappearance of further exacerbations, complete elimination of transfusion requirements, and improvement of symptoms and quality of life.[47]
Catastrophic antiphospholipid syndrome (CAPS) is a rare condition in which blood clots form in multiple organs simultaneously, possibly leading to multi-organ system failure and death. The kidneys are the most frequently affected organ system in CAPS, and patients who survive a CAPS episode commonly experience permanent kidney failure.[48] There are reports in the literature suggesting that eculizumab therapy may be useful in CAPS by virtue of its blockade of complement activity, prevention of acute progressive thrombotic events, reversal of thrombocytopenia, and control of serum antiphospholipid antibody levels.[49][50]


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Sign The Petition!
Every year, millions of Americans dial 9-1-1 from their cellphones. The largest category of calls come from women in domestic violence situations who think help is on the way. Some of these women will die unnecessarily while operators struggle to find out where the callers are located.
Newly proposed FCC regulations could end this crisis by requiring wireless providers to implement new technologies that provide location information.
But wireless companies are fighting to delay the regulations from taking effect, arguing that the FCC's timeline is unreasonable and the costs of implementation are too high. In fact, independent assessments have shown that the existing technologies could be implemented in accordance with the FCC regulations and would allow 911 operators to more rapidly locate those in distress.
Urge wireless providers to stop dragging their feet and implement location services.


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By: Lee Passmore on June 12, 2013 - 4:13pm - Add new comment
We could argue all day about the greatest single-day accomplishment in sports history, and names like Don Larsen, Bob Beamon and Wilt Chamberlin, among others, will be mentioned. As timeless as those feats were, the most unique one-day accomplishment on an athletic field took place 43 years ago, and for obvious reasons, it gets swept under the rug.
By: Lee Passmore on June 6, 2013 - 6:37pm - Add new comment
For the next few days, it's highly possible that Ryan Sluder and Jake Rogers will have some decisions to make about their baseball futures, but they're the types of decisions which are enviable.
By: Lee Passmore on June 4, 2013 - 2:24pm - Add new comment
Bureaucracy has run rampant in every sector of life, and not just in Washington. It seems there's little reason to trust any organization known by initials, be it the IRS, CIA, FBI or NCAA.
But where the first three organizations can be seen as evil at worst and venal at best, the NCAA is downright silly. The list of rules and regulations for the governing body of college athletics may be well-meaning, but it's extremely intrusive.
By: Lee Passmore on May 30, 2013 - 7:32pm - Add new comment
Not to beat a dead horse here, but as we are recognizing the best high school baseball players in the Panhandle for 2013, we could use some help from coaches.
In putting together the Super Team encompassing all classifications, we could use information regarding several deserving players. If there is a player you feel deserves recognition, please send in corresponding stats so we can take him under consideration.
By: Lee Passmore on May 28, 2013 - 3:00pm - Add new comment
With Canyon and Childress both losing on Saturday, that officially ends the 2013 high school baseball season (and for that matter, high school athletic season) for the Panhandle. But that doesn't mean the work is over at this end.
In order to honor the best on the high school diamonds in 2013 in all classifications, we're looking for all-district high school baseball teams for Panhandle area schools. This will help us tremendously over the next two weeks in selecting our Super Team as well as providing a record for fans on how their favorite local athletes fared.
By: Lee Passmore on May 14, 2013 - 12:43pm - Add new comment
I'm hardly an expert on it and I haven't even bothered to look it up, but just a glance at this year's Region I high school baseball brackets reveals what a good year it's been for the Amarillo metro baseball teams, and maybe as good a year as any.
By: Lee Passmore on April 8, 2013 - 4:12pm - Add new comment
It couldn't have been one of the better moments in the history of Follett baseball or coach Shane Woods' career.
Last Friday afternoon, Follett hosted Claude in a District 6-1A baseball game. But it wasn't a good day for Follett, as not only did the Panthers lose to Claude, but in the most humiliating of fashions.
The Mustangs routed Follett, 30-1, in five innings, scoring 14 runs in the first inning while hitting seven home runs. Three of those came from Logan Johnson, two of which were grand slams.
By: Lee Passmore on April 4, 2013 - 3:47pm - Add new comment
Now that all the high school baseball teams in the Panhandle are playing district games, it's time to recognize the team and individual accomplishments in all classifications.
By: Lee Passmore on March 29, 2013 - 9:34pm - Add new comment
This has not been a good week for the guy you're looking at in this blog post. That's mainly because I am no longer that guy you are looking at, having lost an ill-advised bet along with my boss, AGN Media Sports Editor Lance Lahnert, which involved dying my hair black.
But enough of that self-indulgent nonsense. When I thought this week couldn't get any weirder (while being thankful I didn't submit an NCAA Tournament bracket again this year), I ended up trapped in Dick Bivins Stadium on Thursday night, which should come as news to some of you.
By: Lee Passmore on March 25, 2013 - 9:15pm - Add new comment
The way most basketball fans are spending their time these days is following the winning streak of the Miami Heat (now at 27 games, or as a wag suggested on Facebook, three wins short of the Houston Astros projected total for 2013) or lamenting how their NCAA Tournament bracket has collapsed (read fellow Globe-News sports writer Terrence Hunley's blog, which also explains why I haven't filled out a bracket in nearly a decade).
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Dr. Kurt Barnhart
Associate Dean of Research and Engagement
Executive Director of the Applied Aviation Research Center
Dr. Kurt Barnhart has been a member of the Kansas State University Salina faculty since 2007. He is currently the associate dean of research and engagement as well as the executive director of the Applied Aviation Research Center, which oversees the unmanned aircraft systems program office. Previously, Dr. Barnhart was an associate professor and acting department chair of aerospace technology at Indiana State University. He was also a research and development inspector with Rolls Royce and an aircraft systems instructor with American Trans Air Airlines.
Dr. Barnhart holds an Associate of Science in aviation maintenance technology from Vincennes University, a Bachelor of Science in aeronautics from Purdue University, a Master of Business Administration in aviation from Embry-Riddle Aeronautical University and a Ph.D. in educational leadership from Indiana State University.
In addition, Dr. Barnhart has been flying for 30 years and has a commercial pilot certificate with instrument, multi-engine, seaplane and glider ratings. He is a certified flight instructor with instrument and multi-engine ratings and also holds an airframe and powerplant certificate with inspection authorization.
Dr. Barnhart's connection with aviation first began when he was born on a U.S. military installation in Wiesbaden, Germany. He took his first flight with his parents at two weeks old and began traveling through airports by himself around the third grade. Dr. Barnhart started taking flying lessons at age 16 and has even taught his mother to fly.
Mark Blanks
UAS Program Manager, AARC
Mark Blanks was born and raised in middle Tennessee and has been involved in the aviation industry for most of his life. He began flying at the age of 16, earned his private pilot's license the following year and his instrument rating at 19 years old.
Blanks graduated from Middle Tennessee State University (MTSU) with a Bachelor of Science in aerospace maintenance management followed by a Master of Science in aviation systems from the University of Tennessee Space Institute. Blanks has worked in a variety of areas in the aviation industry including aircraft maintenance, flight test and aircraft certification. He joined the MTSU faculty in 2009 as an aviation maintenance instructor and was instrumental in forming the university's unmanned aircraft systems program. In 2011, Blanks was promoted into a fulltime UAS position and the next year became the interim director of Middle Tennessee State University's UAS program.
In January 2013, Blanks accepted the position of UAS program manager at K-State Salina where he oversees the growth and development of the program through joint cultivation of academics and research. He also supervises a staff of highly skilled UAS professionals that perform hundreds of flight missions per year in civil and restricted airspace.
Throughout his career, Blanks has successfully coordinated and completed numerous research projects for federal agencies, private sponsors and internal university groups. Blanks is a federally licensed airframe and powerplant technician and also serves as the chairman for the ASTM F38-02 subcommittee on UAS flight operations and is actively involved in research to support the integration of unmanned aircraft into the National Airspace System.
Michael Most
Assoc. Professor, Aviation
Dr. Michael Most is the academic lead for the unmanned aircraft systems program at K-State Salina. Dr. Most holds a Bachelor of Business Administration in aviation management from Boise State University and a master's degree in photography from Central Washington University. Dr. Most earned his Ph.D. in geographic information systems and remote sensing at Southern Illinois University and later became an associate professor and chair of the department of aviation technologies at SIU. He also holds an airframe and powerplant mechanic certification as well as a private pilot's license.
Dr. Most has authored numerous articles for technical and refereed journals on aviation, aircraft design and the use of geographic information systems to investigate aviation related environmental externalities. He has also delivered several peer-reviewed papers on these same topics. Dr. Most is currently working as a contributing author and co-editor on the second edition of "Introduction to Unmanned Aircraft Systems" that will be published by Taylor and Francis.
Richard Brown
UAS Chief Mechanic
Nathan Maresch
Research Lab Technologist
Nathan Maresch is a K-State Salina alumnus, graduating summa cum laude with a Bachelor of Science in electronic and computer engineering technology. Maresch served as an instructor for various engineering technology labs at K-State Salina before joining the UAS initiative to research the miniaturization of electronic circuits. He has designed a two-dimensional obstacle avoidance system utilizing Fuzzy Logic and is currently participating in a project involving wireless power charging. Maresch holds a private pilot's license and has industry experience in industrial controls and automation. He is a member of the Institute of Electrical and Electronics Engineers and belongs to the Phi Kappa Phi honor society.


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A member of the Gamespot forums was unfortunately scammed by PSP Blender, a suspicious looking website I've stumbled upon more than once. The site offers a very ambitious promise: "With your PSP Blender Membership you receive instant access to millions of files ready to be transferred to your PSP. This includes but is not limited to movies, television shows, video games, music, and PSP software." All of this, for only $37. Sounds too good to be true, right? Of course.
As the Gamespot member learned the hard way, this service simply offers you access to BitTorrent sites, where you download illegal content that's freely available on the shadier parts of the web. However, PSP Blender uses really shady tactics to get a sense of legitimacy. Look at this website, which can be seen frequently on Google AdSense (which PSP Fanboy uses). There are tons of review sites that have PSP Blender as their "top choice." Strange? Well, not when the sites are owned by the same people. A WHOIS record for both sites display the same registrar in nearly the same time. Every "review" on the site promotes PSP Blender. Sounds credible, right?
McAfee's SiteAdvisor shows that PSP Blender received numerous complaints, and the site is now listed as a "Phishing or other scams" website. It appears there are tons of similar sites out there, and all of them seem to be as shady as this one. Next time you're surfing the web, be mindful of scam sites.
Featured Stories
Off the Grid: The Witcher Adventure Game and Star Wars Imperial Assault
Posted on Feb 3rd 2015 2:15PM


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How does David Reeves propose to bring more original content to the PSP? In an interview with GI.biz, the SCEE chief admitted that the PSP had too many uninspired ports of PS2 games, something they're willing to address. The source of their future inspiration will come online: from the PlayStation Network. "Honestly, probably we should have had more original PSP games, and there were some PS2 ports of course, but what you're going to see now is - on PSN there are a lot of good, original games, so the situation you might be seeing in the future is some of those games coming onto PSP. They might be shorter, but they would be far more original."
Games like Calling All Cars, which was recently revealed to be coming to PSP, make a perfect match for handheld gamers, and Reeves understands that. By looking at the response titles receive on the PSN, he's able to see what will work, and what won't work, on PSP. "On PSN you get an instant reaction - 'Calling All Cars, great game, okay, can I have it on PSP?' Okay, why not?"
Could that mean we'll see fan-favorite Super Rub-a-Dub on PSP in the future? One can ... only hope.
Featured Stories
Off the Grid: The Witcher Adventure Game and Star Wars Imperial Assault
Posted on Feb 3rd 2015 2:15PM


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Prior to playing the Anaheim Ducks Tuesday night, Toronto Maple Leafs Coach Randy Carlyle asked, "Who are we playing?"
Randy Carlyle: Full-time head coach, part-time comedian. Who knew?
Yes this is a different Randy Carlyle than the — at times — crusty and surly one who coached the Ducks from 2006 to 2012, winning the Stanley Cup in 2007.
"He's changed quite a bit," said Leafs forward Joffrey Lupul, who had a tumultuous relationship Carlyle when the two were together in southern California. "The way he deals with guys on a day-to-day basis is a bit different. The game evolves and people evolve. But he certainly has changed in that he's coming in, chatting with guys, trying to have a bit more of a relationship with players."
Even the coach agrees that he has mellowed since his time with the Ducks.
"I think so," he said. "There are things that you learn and that you take from your history or experience. There are things that you might do differently now than you would have back then. With a new group of assistants they have different ideas and we have been able to exchange ideas, which has changed my views on a bunch of different things."
"I think there are certain things that you do and I don't think the reactions that took place in my history should have taken place in that arena or for that many people to see," Carlyle added.
Here's an example of the kinder, gentler Carlyle: After his team lost a couple of games and failed to generate much offence the Leafs players were expecting a demanding practice on Monday.
Instead, he started it off by having the players enjoy a game of ball hockey.
"They're expecting to come here and a bag-skate," said Carlyle. "At times we think that's counterproductive. We have to change the mood of our group to a positive one. Usually ball hockey, wrong-handed scrimmages, those kinds of things make it fun for the first ten minutes than you get more of an enthusiastic workout from them, a more committed workout. It's not all doom and gloom."
Randy Carlyle not only coached a number of current Ducks – like Ryan Getzlaf and Corey Perry – but he also played with Teemu Selanne.
"I played with him! Imagine that," Carlyle said. "He's an old bugger that guy."
"Obviously we had a great experience with Randy," smiled Selanne, who has said this is his last season in the NHL. "I'm personally happy to see him do well [in Toronto]. He expects the best out of his players every day and he makes the average player way better.
"I'm so happy to see him doing well. He really deserves that. But it's not a surprise for me."
The 43-year-old Selanne is a 21-year NHL veteran who played with Carlyle. This is Selanne's last season in the NHL and as such, some are dubbing this the Selanne farewell tour.
Carlyle's last season as a player in 1992-93 was Selanne's first in the NHL. That prompted this response from the Leafs head coach: "I was on my farewell tour. And I was the only one who knew about it." Another example of Carlyle showing a sense of humour with the Toronto media, something he rarely did when he was in Anaheim.
Randy Carlyle: Teacher, detail oriented and a much calmer, more relaxed coach than his first go in the NHL.
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The Courtyard Market
Featuring gourmet hot dogs and sausages, fresh salads, snacks, draft beer, wine, and other cold beverages. Located in the Stable area next to Biltmore House.
Meals Offered
- Snacks
- Lunch
Special Considerations
- Children's Menu
- Vegetarian
- Outdoor Seating
- Patio Seating
- Beer&Wine
- Location: Biltmore House and Gardens
- Price Range: $
- Hours of Operation:
- CLOSED for winter


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recipe reviews for:
"A glossy chocolate glaze to drizzle over a Bundt cake. It's also great on cookies and doughnuts."
My Profile | Cooks I Like Reviews | Photos | Recipes | Menus | Blog
Cooking Level: Intermediate
The most-tender new vegetables are here just in time for early spring salads!
Creamy, comforting potato soups will warm you up.
Delicious recipes, party ideas, and cooking tips! Get a year of Allrecipes magazine for $7.99!
See how to make a delicious glossy glaze for cakes, cookies, and donuts.
A simple but decadent chocolate glaze that spreads on easy.
This quick-and-easy chocolate cake is so moist and rich.


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Hello! My name is Emilia.
Alright, I'm a bit old to be just joining up and I am so sad to say I just recently learned about nerdfighters because this kind of website and all of the vlogbrothers' videos would have been a perfect addition to my teenage years. I'm 21 and a future English teacher in New England. I read Looking For Alaska earlier this year because one of the students I am tutoring wanted to read it. In being a good teacher, I started looking for good external (technology) sources of instruction. I subsequently found the vlogbrothers channel and this website. I joined a while ago so I could start playing around with it and show it off to my student.
But, honestly... everything I've seen looks like too much fun and my interests are matched everywhere. As for my interests I've been a Ravenclaw since I was 9, Doctor Who makes my hearts beat, Sherlock is brilliant (even though DAMN YOU, MOFFAT!), and I'm a tribute! (hell, I even wrote my undergraduate thesis--a really REALLY long research project--on dystopian literature and used THG in it). I also read/watch a lot of other things but those seem most relevant here.
Well that's enough about me.. I'm mostly just here to say hello and to have more of the nerdy conversations I used to have on LJ communities back in the day. :)
hello Emilia (i really love that name btw)
welcome to the ning!
21 is hardly old... well, one hopes you wouldn't still be attending Hogwarts...but seriously, you're a baby by Time Lord standards.
i do enjoy a good dystopia and eutopias too, because we should always be hopeful... i know he touched on it again on their main channel, but did you happen to catch Hank's first Hunger Games video on his personal chan from the other day?
thanks! it's lovely to be here.
I'm no longer attending hogwarts but perhaps they'll hire me to teach there soon. Is that what the Doctor is always on about? So much life to live, etc, etc. He's giving me ear-ache.
I didn't catch that video, actually. I'll have to check it out. Thanks for the rec!
well yeah 90 decades to your two... and one is glad to be of service.
speaking of, are you finding your way around this website?
Helllooooo, so glad I found this AMAZING place. I draw, I write...and I read a lot of books. Chameleon Circtuit and AVPM are what I live by...musicmusicmusic is everything. Part of the Nermie Army, I'm Sherlocked (AAGHHH MOFFAT), a Tribute, part of Hogwarts and I will one day be The Doctor's companion. I think that's all you need to know...
so, i take it you found out about Nerdfighteria through nerimon?
Ello there! I'm Joe, I just joint today and already i've spoken to some really fun and interesting people! Just making my introduction official here! :D
welcome Joe! sure you'll continue to meet awesome people.
so...how did you find out about Nerdfighteria?
Well I stumbled on the vlogbrother videos randomly one day and they kept talking about this nerdfighter thing. At first I ignored it but i LOVE their videos and they kept mentioning it. So I looked up what it actually was and found this site. I've been dying to find a fun and friendly community like this and now I have!
Hello fellow nerd fighters, people call me Squ33k.
I'm 18 years old.
I love watch old movies, drawing, and getting lost on the internet.
I enjoy reading comics, manga, Shakespeare and anything horror or SF.
Also studying to be an archeologist :)
Here are some links to help spread the awesome:
Here are some YT links to channels related to Nerdfighteria and educational content!
*Can you think of any more? Pass along any suggestions to an Admin who will then add it to this list should it fit!
© 2015 Created by Hank Green. Powered by


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Kristen may think that things are 'going to be fine' with Rob, but a Summit Entertainment source tells HollywoodLife.com exclusively that her recent words at the Toronto Film Festival couldn't be farther from the truth. Read on for all the details.
Kristen Stewart was busy promoting her now movie On The Road at the Toronto Film Festival late last week. During one of the many press interviews that took place, Kristen mentioned that her and Robert Pattinson were "going to be fine. We're totally fine." Is Kristen delusional?
"Kristen may be delusional if she thinks that things are OK." The source tells HollywoodLife.com that Rob is "still very emotional about the situation and isn't ready to forgive her." The time that has passed has helped, but things are still not OK between them both, if it will be at all. Rob is still "embarrassed" by the whole situation.
Obviously, upcoming press obligations for Breaking Dawn — Part 2 are bound to get stick — and totally awkward! It was when Kristen was asked about those impending run-ins with Rob that she mentioned they're "totally fine."
What do YOU think, HollywoodLifers? Are Kristen and Rob going to be "fine" or is the actress delusional?
More Kristen Stewart News:
- MTV VMA Host Kevin Hart Might Make Fun Of Kristen Stewart
- Kristen Stewart Is 'Ashamed' Of Herself, Says Body Language Expert
- Carolina Herrera: Kristen Stewart Wore Wedding Gown 'To Perfection'
View Comment
Posted at 10:17 PM on September 10, 2012
Posted at 9:06 PM on September 10, 2012
I really don't think she met "her and Rob" were fine, as in together fine. I believe she meant they were fine apart, as far as she knows. I mean, maybe she meant, her and summit. "We" could have meant her and her mom, both dealing with break ups. I haven't seen the interview where she said it, but I am sure she didn't say "Me and Rob are fine". So as far as I know, all those people saying "We" meant Rob and her, are definitly the ones that are delusional.
Posted at 9:00 PM on September 10, 2012
lulu collazo
Posted at 5:55 PM on September 10, 2012
"When you love someone, you love all of them… you gotta love everything about them, not just the good things but the bad things too. The things you find loveable and the things you don't." Kristen should learn that he is not this kind of person. He is toooo proud and it comes with his upbringing and culture, his sisters "would kill him" if he takes her back, he might appear to be a gentleman, but he has behave cruely in spite of what happened. Sure she made a huge mistake, but if he doesn't want to take her back at least he should have a closure and remember this is not about the cheating, this is about a woman he "loved" for over three years. What is his heart made of? Art imitating life, as Edward he doesn't seem to have soul, he is just playing the victim very well… after all he is an actor?
Posted at 5:12 AM on September 12, 2012
@lulu collazo
I strongly suggest you visit your psychiatrist
just becoz Rob does not want kristen back in his life becoz she cheated on him ..does not make him soulless ,and cruel …….he does not want her back in his life becoz he can never trust her now
moreover Kristen does not love him otherwise she would never have done what she did
stop blaming Rob for the mess she created for herself !
Posted at 5:47 PM on September 10, 2012
Robert and Kristen, I love you both and hope you will be together again, but I understend, Robert, that Kristen needs time to realy understend what you, Robert, mean to her and what she lost. Robert, I think she loves you, but she realy did not realised it until now, this awfull situation should have opened her eyes on her feelings to you. With you, Robert, all was always clear to me – I think, Kristen is love of your life and you will always love only her, you was always clear in your feelings and actions towards Kristen. I wish you both strength to live through this hard time and save your love.
Posted at 4:27 PM on September 10, 2012
you are so right!!!! i think she is so into herself that she doesnt realize she blew it big time with rob—-still wearing his HATS, which i am sick of seeing——looking at her pics going to the airport in toronto she looked like the same old kristen—sloppy, messy hair, etc.–i knew it wouldnt take long to see the REAL kristen emerge—she was trying to get sympathy on her way to toronto so her fans would feel her "PAIN"!!!!! it will only be a matter of days before she is flipping off the press and swearing——its going to take her a long time to find someone who loved her as much as rob—-AND by chance if they are back together-i have no sympathy for him because she will treat him like crap just like before –i am hoping he is too smart to take her back—
Posted at 6:27 AM on September 11, 2012
Posted at 6:29 AM on September 11, 2012
Posted at 5:14 AM on September 12, 2012
Posted at 4:04 PM on September 10, 2012
shiiba nana
Posted at 2:42 PM on September 10, 2012
I partially agree with you… You can see how Kristen is delusional when she does not stop wearing Robs clothes like a message "I AM NOT OVER YOU, I STILL WANT YOU TO COME BACK TO ME", I seriously thought at first she was a stalker, but I think she is just desperate that she doesnt even realize wearing his clothes like she wore while cheating on him, could make he remember the whole thing again. This girl is stupid and still REALLY immature. If people think she matured, they couldnt be more wrong. If they get back together she will make Rob suffer again, just wait.
Jackie G
Posted at 7:01 PM on September 10, 2012
No one said she matured, that doesn't happen over night but she is miserable and handling it the best she can for a22 year old with little life experiences . People are just saying this will mature her in the end after all the hell she is going through and will still have to endure during BS2 promo.
Posted at 1:49 PM on September 10, 2012
I will take your words, when you says you are a good journalist, and everythng you write on thie column are base on truth, with substance and coming from a reliable source. Yes reliable source, means Summit.or you have to make up a story through your imagination to get a day pay.
So, your readers will no doubt of Kristen say "we are just ine" – we take her words in face value, she is the source who exactly knows what's going on.
Unless Rob come out and disclaim that statement or at least he is still not fine. No mattter what Kristen say, you guys needed to twist it.
I wish to hear from Kristen saying the same thing as Rob "I am not selling my personal life". go guess it and have fun writing.
Posted at 1:37 PM on September 10, 2012
words matter. I was very proud of the way Kristen handled herself at TIFF. In fact she has handled this entire situation better than most women her age ever could. The girl has heart. HL and the other tabloids have invested so much in trying to take her down, both in terms of her career and her relationship, they are terrified that she and Rob may in fact be " doing fine" and her career is not destroyed as they had hoped. The tabloids have carried out the worse case of cyber-bullying in history. What they have not done, they have inspried other to do. Kristen is a great example of someone who owns up to their mis-steps and leans forward. We could all take a lession from her.
Posted at 5:44 PM on September 10, 2012
KStew Krew
Posted at 12:25 AM on September 18, 2012
Posted at 1:18 PM on September 10, 2012
Just a guy...
Posted at 4:54 PM on September 10, 2012
Posted at 1:14 PM on September 10, 2012
Posted at 12:48 PM on September 10, 2012
Jackie G
Posted at 7:05 PM on September 10, 2012
Posted at 12:47 PM on September 10, 2012
Posted at 5:46 PM on September 10, 2012
Posted at 12:09 PM on September 10, 2012
So she is delusional beacuse YOU took something completely out of context and used it against her. I wanna see what the interviewer actually said because I heard they asked about promo in november with rob, then I heard they jsut said how are you and rob going to get through this november, and then i heard they asked will it be akward this november. I honestly dont think shes delusioal but the media DEFINATELY is!!!!!
Kristen is not delusional. She told friends she wanted ten-thousand different cocks inside her before she got married, and I reckon she's hot enough that she'll easily hit that total by Christmas. (She's already half-way there, despite Nate the Night Janitor, who is the same age as Rupert and cleans urinals at the Poughkeepsie bus station, refusing her offer and telling her, "No thanks honey, you're a sweet-lookin' girl, but I have standards and I don't sleep with sluts.")
Jackie G
Posted at 7:10 PM on September 10, 2012
Posted at 11:33 AM on September 10, 2012
Posted at 10:46 AM on September 10, 2012
Cibelle Cabrall
Posted at 10:46 AM on September 10, 2012
Rob Fan...
Posted at 10:33 AM on September 10, 2012
Posted at 10:12 AM on September 10, 2012
Posted at 10:09 AM on September 10, 2012
Posted at 10:07 AM on September 10, 2012
Posted at 9:53 AM on September 10, 2012
Never seen anyone as mental and cruel as the socalled HL reporters. Stop telling lies and cyber bullying this young girl. Since its so obvious that you don't know anything about what's going on, why don't you just leave her alone and stop making up stories and telling bs abt her days in days out? Enough already. Be ethical and show some professionism and humanity please.
Posted at 10:02 AM on September 10, 2012


text:
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Self-Care Skills
Another area of occupational therapy intervention is self-care skills, such as eating, getting dressed, using the toilet, and bathing. Occupational therapy deals with self-feeding, the hand-to-mouth action of eating. It also deals with eating, including chewing and swallowing, which involves functions and dysfunctions of the oral musculature (muscles). OTRs also focus on the relationship of the swallowing mechanisms to the various textures of food (Hotte, 1979).
Although OTRs often provide treatment in the areas of feeding, in many educational programs or clinics oral motor functioning is an area of specialization for speech and language pathologists. In this case, the OTR and speech and language pathologist address feeding dysfunctions as a team because self-feeding is an area of adaptation rather than remediation. The OTR often plays an active role in obtaining any adaptive equipment that is needed. For example, assistive equipment may include "built-up" utensils (thicker than normal) and spill-proof cups. The OTR focuses on proper positions that help children to function well while sitting. Appropriate positioning is crucial for promoting eating skills and helping to prevent choking. The OTR also provides recommendations about the types of foods that are safe for children to eat without choking.
If a child is experiencing feeding difficulties, the OTR working with the child offers suggestions regarding the mealtime experience based on the individual needs of the child. These recommendations are based on tests that have been completed, as well as clinical observations (Trombly, 1983). The child's OTR often provides a program of therapeutic techniques for the parents or caregivers to use at home. Table 10.4 provides a list of some eating difficulties children with motor impairment may exhibit and for which therapy may be effective (Stern & Gorga, 1990).
An OTR works with parents and staff to help a child develop other self-care skills. Children with disabilities frequently take longer to dress and undress. A therapist may suggest routines and help to establish a time to work on developing self-care skills. Dressing requires a great deal of muscle coordination. It also requires balance and control of muscle tension (Eastman & Safron, 1986). The OTR frequently provides guidance on how to help a child relax and best position a child before dressing the child or helping the child get dressed. The OTR might also provide suggestions about the type of clothing best suited for self-care (Pratt & Allen, 1989).
Eating Difficulties that May Be Helped by Therapy
- Diminished head and trunk control;
- Oral hyper- or hypo-sensitivity to stimulation'
- Jaw thrust—a strong protrusion of the lower jaw;
- Tongue thrust—forceful protrusion of the tongue when sucking, spoon- feeding, chewing, or drinking from a cup;
- Tonic bite reflex—a forceful closing of the jaw on stimulation to the teeth and gums (hypersensitivity);
- Lip retraction (called purse string)—extension of the lips into a tight horizontal line;
- Tongue retraction—a strong pulling back of the tongue into the throat (the pharynx), where it is held against the palate;
- Jaw retraction—the jaw is pulled back, preventing the alignment of the upper and lower teeth during feeding;
- Weak or inefficient sucking patterns.
- Poor lip closure—needed to remove food from a spoon;
- Poor tongue lateralization—the inability to move food adequately inside the mouth from side to side;
- Poor chewing technique;
- Excessive mucus or saliva secretions.
- 1
© ______ 1997, Merrill, an imprint of Pearson Education Inc. Used by permission. All rights reserved. The reproduction, duplication, or distribution of this material by any means including but not limited to email and blogs is strictly prohibited without the explicit permission of the publisher.


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Dear DIA-
It's too difficult to understand so you're saying we should just trust these guys? They're smarter than us? They have our best interests at heart? Ridiculous.
Perhaps you'd like to bring back tithing?
My best wishes,
WHOOMP, and there it is. All of a sudden, financial reform passed the Senate. Perhaps my expectations were unduly distorted by the health-care-reform struggle, but I must confess that the pace of debate over financial reform has seemed almost brisk by comparison. The key struggles over amendments scarcely had time to identify themselves before they were over. I spent the morning racing through coverage of the bill's passage trying to figure out what had made it into the final version, and what hadn't; and judging by the content of the stories most of the major outlets were running, the reporters on the beat were finding themselves stretched trying to figure it out, too.
I think one thing did become clear over the past week or so: there are limits to how much mass political pressure can be applied during these kinds of extremely wonky and detailed legislative processes. Take, for example, the Merkley-Levin amendment. It wasn't until Wednesday that the public debate around the amendment began to clearly crystallise. (In my mind, at least. Admittedly I'm hardly a financial-reform expert, but neither are most Americans, or even most American-politics junkies; that's sort of my point.) Mike Konczal had an excellent post laying out his view of the amendment's necessity. Essentially, it's a way to ensure enforcement of the Volcker Rule, which separates banks' proprietary trading operations from their commercial banking arms so that the taxpayer's support of commmercial banks (through the Federal Reserve's discount window and the FDIC) isn't indirectly subsidising and insuring banks' risky bets on consolidated securities and so forth. Now, Section 619 of the bill proposed by Christopher Dodd already contained such language. So why was Merkley-Levin necessary? Here's Mr Konczal:
Section 619 right involves the Council of regulators, which includes (and will likely be overly influenced by) the Federal Reserve, Treasury and the OCC, would come together and do a study, and then decide what if any restrictions they want to impose. The bank regulators would then go about implementing them.
The problem is that the Council, the way the Dodd Bill is written, has very broad authority to determine what type of regulations they want to impose and what kinds of exemptions they want to give. It allows the Council can rewrite the rules as they see fit. The Section 619 language also doesn't have conflict-of-interest language at all.
Okay. We're already way down in the weeds here. But Mr Konczal also needs to take on a post at Economics of Contempt arguing that Merkley-Levin over-defines what constitutes proprietary trading, which will enable banks to figure out nit-picky ways to circumvent the ban. Mr Konczal responds that the amendment contains language allowing regulators to ratchet up enforcement by going after any behaviours that are clearly "intended to evade the requirements of this section (including through an abuse of any permitted activity)." He points to a response from Senator Merkley's office to this critique, passed on by Matthew Yglesias. This all seems very convincing.
But Merkley-Levin didn't get a vote. Why not? Presumably because the financial industry didn't like it. And who was there to push back against the financial industry on this amendment? Nobody, really. There was simply no way to get any significant amount of public pressure involved in this sort of extremely technical, fast-moving debate. In chronicling a series of battles over amendments Tuesday, Firedoglake's Daniel Dayen, who's been covering the process in extraordinary detail, tried to make the case that this sort of inside-the-Beltway manoeuvring is what led voters to reject incumbents in recent primary elections. I think that's an unconvincing argument. First, the anti-incumbent mood appears to be over-hyped. But second, it's unrealistic to expect that negotiations over a comprehensive financial-reform bill would be simple or transparent. If hostility to the process of complex legislation is what's driving anti-incumbent sentiment, then it's really being driven by hostility to the reality of representative democracy.
Reader comments are listed below. Comments are currently closed and new comments are no longer being accepted.
Dear DIA-
It's too difficult to understand so you're saying we should just trust these guys? They're smarter than us? They have our best interests at heart? Ridiculous.
Perhaps you'd like to bring back tithing?
My best wishes,
"Why not? Presumably because the financial industry didn't like it."
Yeah, sure. Presumably for that reason. QED.
"Okay. We're already way down in the weeds here."
I think that's the key point of the blog. Just finished "The Big Short" by Lewis, and as readable as it is one can get lost in the syntax of CDOs, CDS's, synthetic CDOs, mezzanine tranches, etc.
What's amazing is even when reading about the Mississippi and South Sea bubbles of 1720, a basic understanding of the issues is probably well beyond the constituency of a modern democracy.
I mean, a primary question then was how would one value a stock (and regulate the underlying business) of a company selling at 10 times par whose primary business is purchasing government bonds, and short and long term redeemable and unreedemable government annuities?
I'll buy that the country is in an anti-incumbent mood when the incumbent re-election rate drops below 95%....
An overly defined law has the problem that it can be out of date the minute it becomes law -- the banks with their lawyers have already figured out ways to run around it.
We get public public outrage/support over issues that really are wonky but get oversimplified by the time it reaches the people. Capital gains tax, dividend tax, VAT, basically anything that will affect most people yet involves math.
More reasons why we need some unelected policy-experts for legislators.
Democracy's limits in almost everything ? What is more disturbing is the ignorance of our representatives. But I guess all they have to do is vote as they've been paid to, except when the sovereign People get all worked up about something-or-other.
Firedoglakes coverage is quite good. They are very partisan, but they are always on top of things.
FinReg has been disappointing. Yup. Maybe when the banks crash again we'll decide to do something about it.
"intended to evade the requirements of this section (including through an abuse of any permitted activity)."
Ugh. I wonder if laws on commerce can be more strictly codified instead of using such warmed-over rambling-on like that. Won't that make things bit less obscure for us plebs?
Wait, I thought federal uniform commerce code (sum like that) is written that way?
Or would it all melt down like all others as superficial semantic muddle in our common law court system?
Maybe it's a lost cause given the context of craft sausage that is our legal system.
This bill is a step in the right direction.
Too tiny a step, in my opinion, but that was the price of getting a handful of Republicans (such as Scott Brown) on board.
And the lawyers can argue that regulation was so explicit to begin with that if the regulators had meant X but not Y, then they would have written "but not Y"
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Matt Fiordirosa firstname.lastname@example.com Head, Boys Varsity Wrestling Coach Fiordirosa has been Varsity Head coach at LFHS since 2011. Prior to this, he was the Assistant Varsity coach at LFHS for 2 years and before that, he was an assistant coach at Grant High School for 2 years. Matt teaches in the Wellness Department at LFHS.
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App Description
Soar through the skies in DragonVale Wings!DragonVale Wings is the endlessly fun follow up to the mega-hit dragon collecting game, DragonVale™. In DragonVale Wings, the lovable Fire Dragon takes to the skies in a casual, yet challenging flying game. The flight controls are simple. Just touch and hold anywhere on the screen to soar upwards. Release your finger from the screen and your dragon dives downward. Where it gets tricky is when you need to maneuver between tight passageways and avoid treacherous obstacles. The goal is to fly as far as you can. Score points by collecting coins and gems along the way. How far can you get?
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Life's MissionI will be extraordinary. Nothing less.
Self PortraitThese hands destroy what they create.
PhantomBeauty doesn't always choose the beast.
Happy BirthdayGot a Xbox. Wanted a hug.
To: AllDo not disturb: busy making reality.
Portrait de MoiShe dreamed; she tried; she failed.
OrphanLittle boy sings himself to sleep.
MurderCommit perfect murder. Forget hiding corpses.
vs.They see her.They overlook me.
End of the LineI have achieved everything.... ... ... ... ...What now?
Six Words on LoveLove conquers all...except our distance.
Strange is my 'Normal'"You are strange."Your point is...?
Self-PortraitStraight-A student:Nobody looks any closer
Thank you.Your Heartbeat was the best surprise.
Last chanceReach for the skies; die trying.
LostWent to buy map. Got lost.
All that's Left in Me.I wish to be your smile.
My Portrait, I suppose.I've learned: Realizing your uselessness hurts.