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The implementation of single-use systems—which can deliver significant value through added flexibility, improved production yields, and cost savings—is gaining momentum in the biopharmaceutical manufacturing industry. The initial single-use systems that gained market acceptance consisted of tubing, bags, filters, and connectors. Today, additional types of disposable technologies are being used throughout the production cycle. This article discusses how single-use transfer lines can be incorporated into seed train and final fill applications as well as suite-to-suite transfer operations.
To meet these intense market demands, manufacturers are being forced to continuously boost manufacturing speed and efficiency by relying on innovative technology that can be easily integrated into their existing production processes. One solution that continues to gain momentum is single-use systems, which can deliver significant value through added flexibility, improved production yields, and significant cost savings.
The initial single-use systems that gained market acceptance consisted of tubing, bags, filters, and connectors. These systems were used in bioprocessing facilities for process storage applications and sterile cell culture media. Single-use bioreactors then entered the market in research and development laboratories and rapidly moved into pilot plants and larger-scale production facilities as integral systems for seed train scale-up and production.
Now, single-use transfer lines are emerging as yet another option for manufacturers to save time and cost. Unlike hard piping, the flexible tubing incorporated into single-use transfer lines allows manufacturers to quickly change process steps or convert to a new product without costly and time-consuming cleaning and validation. This is a key advantage for multiple-product facilities in which process requirements change depending on the drug being produced. Innovative manufacturers now incorporate single-use transfer lines in seed train and final fill applications as well as suite-to-suite transfer operations.
The Benefits
The key benefit of single-use transfer lines is the ability to boost productivity and accelerate the time to market by reducing the downtime associated with equipment cleaning and validation. Between each production batch, fixed tubing and re-usable valves must be cleaned to maintain desired sterility. Single-use systems are presterilized and eliminate the need for traditional cleaning and sterilization. This reduced downtime translates into greater productivity and throughput. Instead of the entire process being placed on hold for validation, a single-use system can allow the process to be up and running sooner, thereby increasing output and accelerating the time to market.
Additional cost savings result from reduced labor, chemical, water, and energy demands associated with cleaning and validation. Not only do single-use systems reduce costs, they also improve the safety of drug development and delivery. Presterilized, single-use assemblies reduce the risk of cross contamination that may lead to product loss or reduced yields. This benefit is further magnified for companies that produce multiple products within single facilities.
Seed Trains
Changes in the country's political landscape may affect the pharmaceutical industry market in the future.
The author discusses the various ways in which a quality-by-design program can enhance the extractable and leachable assessment of a drug product.
The use of commercially available media to achieve high titer in early process development is discussed.
The fast growth of the global biopharmaceutical market has prompted global pharmaceutical and biotechnology companies to increase their R&D investment in biologics.
The draft guidance contains policies for drugs that are processed with additional manufacturing steps such as remixing, dilution, and repackaging.
The agency releases five draft guidance documents related to drug compounding and repackaging.
Market forces may limit the success of CMOs.
FDA announced that it would postpone a meeting that would be critical for the advancement of Celltrion's Remicade biosimilar in the US.
Drug shortages are declining, but they're still a serious concern for regulatory authorities, policy makers, and bio/pharmaceutical manufacturers.
The company voluntarily recalls product due to FDA observations of potential sterility problems.
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Medical devices seem to get smaller every year. Think of something as simple as a pacemaker or hearing aid. Like their bretheren PCs, these gadgets that help enhance and extend our lives continue to shrink.
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Latest News
Million Dollar Smiles: Stars With Fake Teeth!
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Agassi, Roddick should reach quarters
After turning pro in 2002, 17-year-old Rafael Nadal of Spain broke onto the tennis scene last year and had some of the best players in the world, including his countryman Carlos Moya, saying at some point in Nadal's career he would be No. 1 in the world. It's pretty amazing that a former No. 1 would make such a bold statement about such a young prospect.
But Nadal, for the last year, has done nothing but improve and gain more confidence with each win. How a teen is able to beat a dominant No. 1 player in the world in straight sets as Nadal did with Roger Federer is a bit surprising. I would not have predicted that. That just goes to show how good Nadal is.
Rafael Nadal (32), Spain, vs. Fernando Gonzalez (21), Chile
Nadal now plays Gonzalez, who has the ability at any time to hit with anyone on the court. He's one of the most powerful players from the ground. Certainly better than he used to be, but one of Gonzalez' greatest vulnerabilities is that he can be inconsistent and sometimes appears not to think about his shot selection. Keeps his opponents really off- balance because they can't get into a rhythm.
However, after Nadal defeated Federer, it's difficult to go against him regardless of who he is playing. But I know, from personal experience, that sometimes after you have a big win over a top player there is a tendency to have a bit of a let down in the following round. If Nadal does not have a letdown, he would be my pick. I might not have said that six months ago.
Pick: Nadal
Andrei Pavel, Romania, vs. Todd Martin, United States
At age 33, Martin only seems to show up at the biggest events. You look back on his record the past two years, and he has a knack for being able to elevate the level of his game when he needs it most. That only comes with experience. Physcially, Martin isn't able to play 25 events per year. But he manages his schedule in an effort to peak at the majors and Tennis Masters Series events.
He's going up against Pavel, who just had somewhat of a surprise victory against Lleyton Hewitt. But you can never underestimate how good Pavel is.
This match is really a toss up. If Martin is able to serve pretty well and control at least 50 percent of the baseline rallies and return of serve, he'll win this match. He cannot afford to let Pavel dictate from the baseline especially with his backhand, which is one of the prettiest and best in tennis.
Looking at Pavel's year, who knows what his results could have been had he not lost to Roger Federer four times. Now that he knows Federer is out of the tournament, maybe he'll play some inspired tennis and look at this as a great opportunity to reach the quarters. But when forced to pick, expect Martin to win while going the distance, as he has often this year. Pick: Martin
Guillermo Coria (3), Argentina, vs. Julien Benneteau, France
As predicted, Coria has been a player to reckon with here on a surface other than red clay. Depending on how this draw sets up for him, don't be surprised if he reaches the final with an opportunity to win his first Tennis Masters Series event on hard court; his only Tennis Masters Series title came on clay at Hamburg.
Certainly, experience will play a factor in this match with qualifier Benneteau lacking in that category. Experience is something you can never put a price on; you only gain it by succeeding during hundreds and hundreds of matches under pressure. Pick: Coria
Sebstien Grosjean (12), France, vs. Nicolas Kiefer, Germany
Confidence is a wonderful thing, and that's exactly what Kiefer has right now. He's a former top 10 player, who has been forgotten until very recently. Kiefer fought through various injuries to start making a name for himself again in 2004. Only three months into the season, and he's been in the finals of Memphis and Scottsdale. He matches up very well with Grosjean.
Players who have strong groundstrokes typically give Grosjean problems. Kiefer, though consistent from the backcourt, is not an overpowering player. That will allow Grosjean to play his consistent, backcourt tennis, until he takes the opportunity to unload off the forehand side.
My gut tells me that, although I ought to go with Grosjean in this match, there's something about Kiefer and his confidence that might pull him through. Pick: Kiefer
Vincent Spadea, United States, vs. Paradorn Srichaphan (9), Thailand
Again, what can you say about confidence? That's all Spadea has right now. It's hard to figure out why a player gains confidence, and what causes them to lose it. But Spadea, recently off of his first career title, has a ton of confidence.
He matches up very well with Srichaphan. At times, Srichaphan has one of the best serves in the game, but Spadea's return of serve, at times, is also the best in the game. So those two strengths cancel each other out in this match. Spadea is going to have to control this match like he does most of his matches by controlling the point from the baseline. He can't allow Srichiphan to dictate, come into the net and make Spadea counter-punch. Spadea must control the match with penetrating groundstrokes. If he can do that, Spadea should win in three sets.
Pick: Spadea
Augstin Calleri (20), vs. Andre Agassi (4), United States
It's very tough to put any money against Agassi at an event he's won so many times on a court he probably loves. Plus, against a player who is arguably better on clay courts than hard? That would be foolish. The way Agassi destroyed Max Mirnyi shows he's feeling very good about his game. He's a player who thrives on his ability to dominate his opponent. When he can do that, he's very dangerous because that alone is what builds his confidence. Calleri has got to hope that Agassi is off of his game and take advantage. But we'll see Agassi in the quarters.
Pick: Agassi
Carlos Moya (5), Spain, vs. Tommy Robredo (19), Spain
It's hard to call Moya an underachiever because he has won a major and been No. 1 in the world. But based on his game, he should have at least three or four majors to his name and spent more time as No. 1 other than a brief period back in 1999. He's obviously feeling pretty good about his game, having beaten Dominik Hrbaty, who has already won three titles this year. But Moya's got to be able to back it up with another victory against a confident Robredo.
Moya will probably have too much game for Robredo because he has more weapons, particularly off his serve and his ability to come in and attack. However, these two know each other's games so well that there's going to be no intimidation on Robredo's part.
Pick: Moya
Guillermo Canas, Argentina, vs. Andy Roddick (2), United States
Roddick is one of those players who doesn't get afraid, nervous or intimidated by big match situations. He's one of the few who relishes playing in front of a big crowd where all the expectations are on his shoulders.
He's from South Florida, an hour up the road from Key Biscayne, and a lot of people will be supporting him. There's also the pressure to beat Andre Agassi in the semifinal. So, it's easy to look forward a couple of rounds to potential matchups, but that could be one of the worst things he could do against Canas.
Canas is one of the best fighters in the game of tennis -- proving that in Australia by beating Tim Henman in five sets. There's not an ounce of Canas that feels he cannot win this match. So Roddick is going to have to take it from him. This very well could be the best match of the round of 16. From Canas' standpoint, he'd prefer to play in the day and the hotter it is, the better it is. It gets him in that grinding frame of mind. Regardless of who wins, this will be a great match.
Pick: Roddick
MaliVai Washington, a tennis analyst for ESPN, reached the 1996 Wimbledon final.
- Looking Beyond Serena
- Looking beyond Serena Williams at Indian Wells.
Wilansky »
- Azarenka Gaining Confidence
- Victoria Azarenka is slowly starting to show old form.
Garber »
- Don't Forget About Ferrer
- Don't forget about little David Ferrer.
Racket Response »


text: hello everyone,,been reading this forum for a bit, just decided i never introduce myself. i'm 63, live in the woods, and love to smell powder burn!!i've had a CCW permit for a number of years, shot ipsc since 1995, shot .45's for 40 years. my carry weapon of choice now is a s&w9c that i picked up,, and could'nt put down.. look forward to being a positive and helpful member of this fine forum.


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Epson has rolled out a new projector that can turn walls, tabletops, and other flat surfaces into interactive learning environments.
The new BrightLink 455Wi is an ultra-short-throw LCD model capable of projecting an 80-inch (diagonal) image from a distance of 10 inches. It can operate as close as 2.8 inches from the projection surface and can be coupled with an optional table mount to turn horizontal surfaces into interactive tables.
The projector itself offers a native WXGA resolution (1,280 x 800 pixels) and a brightness of 2,500 lumens. It includes two digital IR pens (and pen tray) for interacting with projected images.
Other features include:
The BrightLink 455Wi is available now with standard wall mount hardware for $1,699 through Epson's Brighter Futures program or $2,199 street. An adjustable wall mount will be available in May for $519, and an adjustable mobile cart will also be available in May for $1,499. Further information can be found here.
About the Author
Executive Producer David Nagel heads up the editorial department for 1105 Media's education publications — which include two daily sites, a variety of newsletters and two monthly digital magazines covering technology in both K-12 and higher education.
A 21-year publishing veteran, Nagel has led or contributed to dozens of technology, art and business publications.
He can be reached at firstname.lastname@example.com. You can also connect with him on LinkedIn at linkedin.com/profile/view?id=10390192 or follow him on Twitter at @THEJournalDave (K-12) or @CampusTechDave (higher education). A selection of David Nagel's articles can be found on this site.
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Success in a 1-to-1 environment depends on strong leaders who build a culture of innovation and collaboration. Learn the key things that you need to know for a successful 1-to-1 rollout at your school. Read more...
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Welcome to Fashiolista! Discover, save & share the greatest fashion findsfrom anywhere on the web! Sign in with Facebook
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In this throwback episode of The Break, KC and the family discuss celibacy and the power of sex during dating.
In this episode of The Brown Girl Hour T & KC are all laughs responding to listener feedback!
Listen in as KC and the family chat about whether or not chivalry is dead in Los Angeles.
Check out this week's THROWBACK episode! Sit back and listen as KC and the fam discuss having platonic relationships wit ...
Check out our first (of many to come) listener feedback podcast!
Is an educated Black women short on options when it comes to dating Black men?
Is it possible to have a healthy "friends with benefits" relationship?
Is interracial dating the ONLY option for Black girls in college?
Check out a special podcast episode, featuring Rod and Karen from The Black Guy Who Tips podcast!
Do these rules apply to new millennium dating?


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A picture taken on February 10, 2015 in Paris shows a bowl of popcorn. To most people, it may be just a fun food to munch while watching a movie. But to a couple of French investigators, popcorn is a biomechanical enigma waiting to be explained. In an unusual study published on February 11, engineers Emmanuel Virot and Alexandre Ponomarenko carried out experiments into what makes popcorn, well, pop. Cameras recording at 2,900 frames per second helped show what happened when a kernel of corn strutted its stuff. AFP PHOTO / LOIC VENANCELOIC VENANCE/AFP/Getty Images
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Celebrity Buzz
Your daily dose of hot news & gossip.
Posts filtered on Tag
Cowell planning several weddings
AP Simon Cowell is planning to marry fiancee Mezhgan Hussainy four times – he will have several wedding ceremonies across the globe, according to the music mogul's brother. The American Idol judge confirmed last month he will exchange vows with make-up artist Hussainy after their whirlwind romance.
[Read More]
Slain boy's stepdad must pay Dixie Chick's legal costs
Natalie Maines LITTLE ROCK, Ark. — A federal judge says the stepfather of one of three Arkansas boys slain in 1993 must pay Dixie Chicks singer Natalie Maines' legal costs stemming from a defamation lawsuit he filed against the band.
[Read More]
Conrad Murray rules out plea bargain in Jackson case
Associated Press Murray By LINDA DEUTSCH Associated Press LOS ANGELES — The lawyer for Michael Jackson's Houston doctor says there will be no plea bargain in the involuntary manslaughter case, though he worries whether an impartial jury can be seated for a trial in the death of one of the world's most famous and idolized […]
[Read More]
Swayze's widow considers adoption
Patrick Swayze's widow is considering adoption in a bid to start the family she and her late husband always wanted. Dancer/actress Lisa Niemi admits her biggest regret in life is not investigating fertility treatment while the Dirty Dancing star was alive. She's still devastated by the miscarriage she suffered during her time with Swayze, and […]
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Ringo Starr blames eBay dealers for autograph ban
CREDIT Ringo Starr Beatles legend Ringo Starr has opened up about his controversial decision to stop signing autographs for fans – insisting he only imposed the ban because he was sick of seeing his dedications up for sale on the internet. The drummer announced plans to deny requests for his signature in a 2008 video […]
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TV-Broadway star Dixie Carter dies at 70
Carter Associated Press LOS ANGELES — Designing Women actress Dixie Carter, who used her charm and stately beauty in a host of roles on Broadway and television, died Saturday. She was 70.
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Anna Nicole estate appeals denial of husband's fortune
Associated Press SAN FRANCISCO — Lawyers for the estate of Anna Nicole Smith have appealed a ruling that gave her none of her late billionaire husband's fortune.
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Federline apologizes to ex for dumping her for Spears
AP Shar Jackson was engaged to Kevin Federline when he began a romance with Britney Spears. Britney Spears' former husband Kevin Federline has apologized to his ex-fiancee for dumping her to pursue his romance with the pop superstar. Federline met Spears while he was working as one of her backing dancers and he was engaged […]
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Attorney: Erin Andrews getting death threats
Associated Press LOS ANGELES — ESPN reporter and Dancing with the Stars contestant Erin Andrews has been getting death threats in a stream of e-mails to a media outlet, an attorney for Andrews said on Friday.
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Jennifer Hudson becomes Weight Watchers rep
Associated Press Oscar winner Jennifer Hudson is the latest celebrity to become a weight-loss spokeswoman.
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Key Info |
This is the ultimate get away from it all villa and is especially suited to romantic and relaxing breaks and groups of friends wanting to chill out. You have magnificent beaches 5 minutes away known as the Hawaii of Europe. Golf, town, water sports also nearby if you fancy something more energetic. We have every extra imaginable in this villa, you may well find cheaper on site but beware we have heated pool,hot tub,side gates,child friendly,english channels, games etc.
This luxury development has already been visited by Vogue magazine (photo shoot) and Real Madrid Football Team (R&R).
Facilities include heated roof top jacuzzi, private lagoon shaped pool, hammock, all rooms en suite. Electric grill replaced BBQ as BBQ was damaging our lovely astro turf on roof.
Size | Sleeps up to 6, 3 bedrooms |
Nearest beach | Corralejo 2 km |
Will consider | Corporate bookings, House swap, Long term lets (over 1 month), Short breaks (1-4 days) |
Access | Car advised, Wheelchair users |
Nearest travel links | Nearest airport: Fuerteventura 30 km, Nearest railway: N/a |
Family friendly | Great for children of all ages, Suitable for people with restricted mobility |
Notes | Some pets are welcome - please contact the owner, Yes, smoking allowed |
Luxuries | Private outdoor pool (heated), Jacuzzi or hot tub, DVD player |
Pool | Private outdoor pool (heated) |
General | Air conditioning, TV, CD player, Safe, Satellite TV, Wi-Fi available |
Standard | Kettle, Toaster, Iron, Hair dryer |
Utilities | Clothes dryer, Dishwasher, Cooker, Microwave, Fridge, Freezer, Washing machine |
Rooms | 3 bedrooms, 3 bathrooms of which 3 En suites, Solarium or roof terrace |
Furniture | Single beds (2), Double beds (2), Cots (1), Dining seats for 6, Lounge seats for 6 |
Other | Towels provided, High chair |
Outdoors | Private outdoor pool (heated), Balcony or terrace, Private garden, BBQ |
Access | Wheelchair users, Secure parking |
Further details indoors | My personal style of décor reflects the fact that the sun shines circa 360 days a year in Fuerteventura and is focussed in whites and creams to bring the light in. One king, one double and one twin room all en suite with calm restful shades. A fully equipped kitchen opens into a restful dining/living room where you can relax after a day in the sun. Privacy is the name of the game here with high walls which shut the world out and allow you to enjoy your own piece of heaven. Especially for children we have connected the twin room to the master as none of the villas have bedrooms which connect by hallway, this makes us the only child friendly villas on site. We also have ninetendo wii, ipod speaker, dominios, lilo's, colouring , satelitte tv for your convenience. |
Further details outdoors | Outside you also have private parking and lots and lots of room to relax both by the pool and on the terraces. The complex has a lovely bar and restaurant and gym and sauna (small local charge). This complex has no apartments where noise gathers at communal pools, it comprises solely of 3 bed, 3 bath villas so the tranquillity is second to none. |
Further details | Welcome pack provided on arrival. Smokers, please smoke outside. We have two identical villas so availability is good |
Fuerteventura is one of the Canary islands blessed with what is arguably the perfect climate. Warm days and a lovely light breeze to keep you cool.
I would recommend you hire a car and get out into the other villages and see the historical sites and get a feel for local life there.
Beaches are truly amazing, anyone on their first trip to Fuerteventura could be mistaken they are in the Caribbean with miles upon miles of vast uncrowded white sand beaches.
Golf, water sports and dune buggies are all available near the villa.
Corralejo and indeed Fuerteventura has many festivals including windsurfing and swimming races and times to celebrate. If you are unsure when to travel visit Fuerteventura.com to find yourself a special date.
Personally I love the vast beaches and it is easy to find a place where you can bring a picnic and be the only person for a mile.
Having visited the set of the English patient in Africa it is like a cross between that dessert feeling and the beaches of the Caribbean only much less crowded.


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League unveils Team of the Century
RUGBY League's Team of the Century was named last night at the Centenary Ball.
Qld Cup Preview and Burleigh's Pink Day Out
PREVIEW notes for the sixth round of the Queensland Cup.
Previews - Rhinos v Celtic Crusaders and Crusaders Colts v Gateshead
CELTIC Crusaders are preparing for their toughest game yet as they travel to Super League and World Champions Leeds Rhinos in the Carnegie Challenge Cup on Friday
Skilled Park honoured as part of Centenary celebrations
SKILLED Park, the new home of the Jetstar Gold Coast Titans, has been honoured as a site of historical significance to rugby league.
Broncos out to storm Titans' Temple
BRISBANE will use the buzz of playing at the Gold Coast's new Skilled Park fortress, christened the "Temple of Doom", to topple the Titans on Friday night.
Emotion to lift Eels for grudge match
PARRAMATTA will look to channel the emotion of a drama-charged week into their football when they host an equally desperate Manly side on Friday night.
Goodwin re-signs with Raiders until 2011
CANBERRA have put their faith in Bronx Goodwin to become the club's long-term solution in the No.1 jumper, re-signing him until the end of the 2011 NRL season.
Sammut starts to take control at Penrith
YOUNG Penrith NRL halfback Jarrod Sammut says he is only just getting comfortable after initially being overawed by many of his premiership-winning teammates.
Top of the table clash in NSW Cup this weekend
THE Bears extend a general invitation to all Newtown players, staff, officials and supporters to come back to the North Sydney Bowling Club after the game...
Deacon extends contract with Bulls
BRADFORD Bulls have today announced that Paul Deacon has agreed a new two year contract...
Crusaders on hand to promote Millennium Magic
FRESH from their Carnegie Challenge Cup match at Leeds Rhinos, the Celtic Crusaders squad will make an appearance at the Bridgend Designer Outlet...
AT 100 years, 2 months and 12 days old the North Sydney Club finds itself on top of the table and undefeated and about to face currently it
Lawrence to stay with NRL Tigers
BOOM West Tigers centre Chris Lawrence will remain at the NRL club until the end of the 2011 season after agreeing to a two-year contract extension.
Robinson tipped to play despite illness
PARRAMATTA officials are confident Chad Robinson will play against Manly despite the workaholic lock missing training on Thursday due to a stomach virus.


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Blackburn 0 Manchester City 2: match report
This was a fitting venue for Mark Hughes and his expensively assembled team to begin their assault on the Champions League coterie. Ewood Park is the birthplace of sugar daddy football, where a rich man's millions brought glory to an unlikely club. The scale has changed Uncle Jack Walker had a fraction of the vast wealth assembled by Sheikh Mansour but the mission is the same: fast-track success. Kenny Dalglish spent Uncle Jack's millions on Alan Shearer and Chris Sutton to deliver Blackburn the 1995 title, giving this club a fleeting spell amongst the elite. City seek more sustained success and building remorselessly towards it. With ambition comes expectation, and with every million spent, the limits of what City are expected to achieve have been pushed further and further back. Against his former club, which he taught to box above its weight again, his new team faced their first public examination of substance. They passed. Just. All the pre-match pressure seemed to evaporate with less than three minutes on the clock. Blackburn had piled forward and Shaun Wright-Phillips found space on the right wing. Emmanuel Adebayor picked up the ball in the centre circle and sent him scampering off with a superb ball into the space. Wright-Phillips cut back inside, leaving the retreating Stephen Warnock on his backside, and pulled the ball back to Adebayor who was sprinting forward in support. The £25million signing from Arsenal met it with a crisp, first-time shot that whistled past Paul Robinson at the near post. Piece of cake, this, surely? The euphoria did not last long. Blackburn began a sustained and intense aerial assault on the City defence, hitting direct balls at Benni McCarthy and Jason Roberts. In trying and succeeding to avoid relegation last season, Sam Allardyce had made a Faustian pact to play some of the most miserable and negative football of recent seasons, fielding his giant defender Chris Samba as a lone striker. Ok, while this was hardly the prettiest stuff you will have seen it was direct football played positively, with two strikers and two wingers, Morten Gamst Pedersen and El Hadj Diouf, providing a remorseless barrage of deliveries. With the cheapest season tickets in the league and a near full house, it was the kind of aggressive football to get the supporters behind the team. It was a rough introduction to his new existence for Kolo Toure, as Roberts repeatedly battered him in aerial challenges. The impressive Rovers debutant Steven Nzoni went close to equalising, as did Roberts when, seizing on to Samba's knockdown, he could not keep his side-footer down. With half an hour gone Shay Given was forced to pull of the first of several astute saves. Diouf's corner unerringly picked out the 6ft 4in Samba and Given had to dive low to his left to keep out the Congelese defender's thumped header. Richard Dunne had made several important blocks, typical of his fire-fighting style, but when Roberts breezed past him in the City box, you could see why Hughes feels he needs a centre half with more mobility, like Joleon Lescott say. Fortunately for Dunne, McCarthy's shot from Roberts' drag back was too close to Given. City continued to struggle to impose themselves on the game Given had to make another good save to deny Roberts in the second half and their forays into the Rovers half were only really effective when they counter-attacked at pace. Ireland wasted a great chance on one such break, curling his left-footed effort high and wide. This approach is clearly not sustainable. City could not retain possession, the team is not designed for it. The central midfielders, Ireland and Barry, are box to box players the more reflective Nigel de Jong was left on the bench and they need a player of his composure to anchor the more freewheeling elements, Robinho foremost. The Brazilian, with his pathological irresponsibility to all things defensive, destroys the balance of the side if they plays as a left winger 4-4-2. Not only is Wayne Bridge left isolated but with Robinho's penchant for improvisation over structure means the whole team looks lop-sided. Hughes will have to find a system to accommodate his maverick. He'll also have to find a way of fitting Carlos Tevez in. There is palabale schadenfreude among the City support in their crowing over having poached one of United's favourites and his arrival as a second-half substitute he's recovering from a heel injury was greeted rapturously. He nearly scored, too, playing an excellent extended one-two with Wright-Phillips only to see his shot blocked by Robinson. The risk with all these new men with big salaries coming in is that Hughes overlooks the talents he already has. It is essential he does not do that with Ireland, the most improved player in the Premier League last season. His development must continue and it was no surprise that, with Blackburn over-extended in quest of an equaliser, it was his goal which gave the result a light blue gloss. Ireland got in behind Givet, who had slipped on the slick top, and made to go round Robinson. The Blackburn goalkeeper committed himself but Ireland did not shoot checking back inside, looking for an option. Robinson got up but back away from the City midfielder who impishly passed the ball into the net. Along with Wright-Phillips and Richards, Ireland threw his shirt into the away end after the final whistle. Excessive to say the least. Clearly, managing expectation is going to be tough.
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The 2014 ITEN Wired Summit was an enormous success, with over 300 attendees from across the Gulf Coast and enthusiastic responses to this year's programming and speakers. If you missed it, or want to review, many of the speaker's presentations are now available for download.
Thank you to all of our sponsors, speakers, volunteers, and venues for helping to create this successful event and for supporting iTen Wired and making it possible for all our attendees.
We hope that everyone made connections, learned something new, and got a renewed sense of ambition and positivity for the potential of the Gulf Coast tech community. We've only just begun to scratch the surface of success.
If you haven't already, please sign up for our newsletter and join us on Facebook and Twitter for local and regional tech news and information throughout the year.
Please take our post-event survey and let us know what you liked about this year's summit and what can be added or improved for the 2015. Thank you for your insights.
Signup for email updates and be the first to know about the 2015 Summit.
Whether you are an executive, entrepreneur, IT professional, student, or just looking for insights into the current issues that concern information technology, the ITEN Wired Summit is a valuable resource. There will be many networking opportunities with peers and area leaders. No matter your industry or location, you'll be sure to find interesting and engaging people and topics at this year's summit! Last year's Summit sold out, so register early.
ITEN Wired is a conference hosted by IT Gulf Coast with support from the Greater Pensacola Chamber of Commerce. The annual summit provides networking and learning opportunities for executives, entrepreneurs, technology professionals and academia to foster local economic development efforts surrounding innovation, technology and entrepreneurship.


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How to Check the Freshness of Baking Powder
One Methods:Hot water method
If you haven't used your baking powder in a while and you're unsure about its freshness, try this method to check it. If the baking powder isn't fresh, it won't do its work in helping your baked goods to rise properly.
Hot water method
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- Baking powder should be stored in a dry, cool place. Moisture will cause it to clump and heat will reduce its effectiveness.
Things You'll Need
- Baking powder
- Teaspoon
- Jug
- 1/4 litre (8.4 fl oz) of water
Sources and Citations
- Cook's Illustrated Magazine, 365 Quick Tips, p. 26, (2000), ISBN 0-936184-50-7 – research source
Article Info
Categories: Baking
In other languages:
Español: Cómo comprobar si el polvo de hornear sigue fresco, Italiano: Come Controllare la Freschezza del Lievito in Polvere, Русский: проверить свежесть разрыхрытеля, Português: Como Verificar se o Fermento Está Fresco
Thanks to all authors for creating a page that has been read 7,675 times.


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Fostoria Art Glass Shade browse these categories for related items... Directory: Antiques: Decorative Art: Glass: American: Glass Shades: Pre 1920: item # 920313 Please refer to our stock # 2009715-2 when inquiring. Great Lamps and Shades Leesburg Virginia 20175 301-370-3597 Guest Book 450.00 |
This Fostoria Green and Gold Zipper Shade on Light Green base glass with Gold Interior was made in Fostoria Ohio between 1910 and 1920.This shade is 4.5 tall, 5 wide at the bottom opening and has a standard 2.25 fitter. This shade is not signed. The shade is in perfect condition with no chips, cracks or repairs. |
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I AM SPEECHLESS IN REGARDS TO CUSTOMER SERVICE. ITS THE BEST IN THE WORLD! I HAVE ORDERED MORE THAN 4 TIMES AND IT KEEPS GETTING BETTER AND BETTER....Read More ->
I've ordered many things with MJM! Amazing quality shipping, for the lowest price. Can't even think of a better company, thanks so much!Read More ->


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endangered-species Subscribe to Feed
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This Friday is Endangered Species Day, do you have any on your campus?
On Friday, May 18, 2012 join National Wildlife Federation in recognizing Endangered Species Day, a day to learn about the imperiled birds, fish and plants in your area and also share the importance of wildlife conservation with friends and family. […] Read more >
Back from the Brink: A Photo Gallery of Birds Helped by the Endangered Species Act
This Friday, May 18, 2012, the nation celebrates Endangered Species Day. To mark the event, we're sharing photos of five North American bird species that represent endangered species success stories. To ensure that these birds continue to recover–and to provide […] Read more >
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Last week the 2012 Farm Bill began its long journey through Congress in the Senate Agriculture Committee, where it passed 16-5. While we think it is a good starting place, there are still critical protections for wildlife that are missing. […] Read more >
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On Saturday May 5, 350.org is holding a worldwide Climate Impacts Day to draw attention to how climate change is causing more extreme weather and climate events, often with devastating consequences. We all have experienced or read news accounts of […] Read more >
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Hi My name is Gharbi, from Germany! MJM has the best customer service in the world! Super fast, and good items price! I´m happy! ;)Read More ->
It's refreshing to find an Internet magic shop that almost feels like a "brick and mortar" shop. Brandi and Jeff are "flesh and blood" people...Read More ->


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29 Aug 2014
IN A GROUND-BREAKING DEAL, the franchisees of TaxAssist Accountants have worked alongside its executive management to buy out the business.
TaxAssist, 25th in the Accountancy Age Top 50 Survey of firms with £27m in revenues, is now co-owned by a tranche of its franchisees, senior management and long-standing business partners.
Further reading
The franchisees that have bought into the franchise now own 32% of the business, while chief executive Karl Sandall, business development director Sarah Robertson and operations and finance director Phil Sullivan own 53%.
They will form the board alongisde two non-executives: John Chambers of Ashton KCJ Solicitors and a representative of the franchisees.
"We believe this is a first in the UK and internationally," said Sandall.
"Franchise operations have been bought by their management teams, but as far as we are aware never in partnership with their franchisees. More than half of our network, including franchisees and their staff, have invested in the business and many more have expressed an interest in buying shares in the future as they are placed on our internal market. We're delighted at the response to this offer and the even closer working partnership it creates for our business."
John Westgarth, who founded the business in 1995, retires as chairman and director.
Stephen Reed, corporate finance director at Price Bailey, Martin Simons, Senior Commercial Manager at HSBC and Mark Whittaker, Corporate and Commercial Partner, Ashton KCJ Solicitors advised on the deal.
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If budgeting is to have any value at all, it needs a radical overhaul. In today's dynamic marketplace, budgeting can no longer serve as a company's only management system; it must integrate with and support dedicated strategy management systems, process improvement systems, and the like. In this paper, Professor Peter Horvath and Dr Ralf Sauter present what's wrong with the current approach to budgeting and how to fix it.
In this white paper CCH provide checklists to help accountants and finance professionals both in practice and in business examine these issues and make plans. Also includes a case study of a large commercial organisation working through the first year of mandatory iXBRL filing.


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In Phoenix Wright: Ace Attorney Trials and Tribulations players star as a defense attorney, who must prove a seemingly guilty clients innocence no matter how dire the circumstances may seem. Phoenix will face the toughest prosecutor yet as the mysterious hard-boiled Godot will try to take him down at any cost. The complete story of Phoenix Wright comes together as truths are revealed in twisting storylines and intriguing gameplay. Players must collect evidence, survey crime scenes, weed through inconsistent testimonies, and overcome corrupt agendas to ensure that justice prevails.
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Bemidji Pioneer
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James Laurinaitis Back-to-Back Butkus
He's just a monster. Last week against Illinois was a highlight reel. 8 tackles, 1.5 for loss, .5 sack, pass defensed, forced fumble and a QB hurry.
For the season the numbers are gaudy: 109 tackles, 4.5 for loss, 3 sacks, 2 picks, and 4 passes broken up. OSU played the 8th most difficult schedule this year, and obviously Laurinaitis is constantly being keyed on, and he still puts up monster stats week after week. (Edit) with two games left to play, he'll almost assuredly have a better season statistically in '08 |
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Hi All,
I hope this is in the right section. I spend a lot of time in the woods and usually have my .45 on my hip. While I know a good heavy caliber revolver with FMJ rounds would be best for bear or other wild animal the .45 is all I have.
Does anyone know where I can get GOOD reliable all steel or at least quality FMJ rounds that I can use instead of just the standard JHP rounds I carry for self-defense. I want something that is more reliable than the regular FMJ that we all buy for the range, and want something with the most penetration for larger animals.
If i'm wrong on all of this please let me know what would be best for larger animals.


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Q: Ms Virgo asks "Please let me know when I will move house. I have been living in the same house for 13 years & love it but want to move into my own home soon." (Birth Data supplied) A: Your 4th House of Home and Family is ruled by... read more »
Oscar night is coming and there may be many dark horses in the running. Although Daniel Day Lewis was the favorite early on, Bradley Cooper is now getting lots of attention for his performance in Silver Linings Playbook, and critics are also saying... read more »
We're coming up to another Mercury retrograde, but from all reports, it's been feeling like Mercury retrograde since the holidays! Is that your experience? Mercury goes retrograde from February 23 to March 17, 2013 in Pisces. ... read more »
Kate Middleton can't get a break. From suffering a rare condition that made her quite sick in the first trimester, to now paparazzi hunting her down on a holiday to shoot bikini pics of her. Sure, she is a public figure, but will she ever get a... read more »
Conflicting reports on Mila Kunis and Ashton Kutcher's relationship broke on Valentine's Day. One report said they were moving in together, while another said Ashton was cheating. With Mila supposedly moving in to Ashton's Hollywood... read more »
In our go-go-go culture, it's oftentimes challenging to stop, especially when we are faced with things from which we usually want to run away. And yet with Saturn stationing retrograde in Scorpio on Monday, February 18, over the next week stopping... read more »
Start the year off right by honoring your true colors and making this New Year's resolution the most powerful yet. Once you discover your true aura colors - what physicists call the electromagnetic field - and the personality, emotions and... read more »
Happy Valentine's Day! With Hollywood being the craziest place for make-ups and break-ups, here's a look at the best way to say "I love you" to the stars -- and celebs! Aries: They adore surprises of any sort -- presents,... read more »
Valentine's Day occurs with mental Mercury and intense Mars in the uber romantic and fantastical Pisces, and Venus in eclectic Aquarius -- so creativity and extreme shifts are destined to happen. As for which celebrities will experience the... read more »
Bruce Willis is back as John McLane, as A Good Day To Die opens nationwide on Valentine's Day -- the next in the Die Hard series that had its last installment in 2007. While the films have been a Willis-fan favorite, will this one be a hit or a... read more »
With the dual sign of Gemini Rising, Susan Kelly is quite comfortable wearing two chapeaus: stylish writer and astrologer! For close to two decades, she has commented on trends in fashion, beauty and home décor. Her past fashion and beauty... read more
Considering some of the tumultuous celestial configurations of the near future attempting to befuddle and ensnare... read more »
Socialize! Your life opens up in positive ways this week as Jupiter in Leo trines Uranus in Aries on March 3! Then, your... read more »


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Story Synopsis
Plot Revealed Below!
A serial killer, who targets courting couples, is on the loose in London just as a great smog descends on the capital, shutting the entire city down.
When the mutilated bodies of a young couple -- Marcus Hare (a photographer) and Diana Hunter (a cellist) -- are found in Battersea Park, the press believe it to be the return of the 'Butcher' who is believed to be responsible for a series of unsolved murders from the thirties.
Marcus took photos wherever he went; the couple's journey that evening is determined once they are processed. Also found is a cinema ticket stub and a card for the 'English Maiden' -- but what's the 'English Maiden?'
Jericho interviews the staff at the cinema, which is playing Bridge on the River Kwai, but no one recognizes Marcus and Diana. The theater has 3,000 people in for each show and they can't possibly remember everyone.
Diana's guardian, Philip Pickering, was also her cello teacher. He reveals that he did see her after she left her practice session -- he went round to Marcus's house to confront her. He had been worried that she was losing focus on her music and she had a big recital coming up that she wasn't prepared for. He didn't mention this before because he had slapped her and was too ashamed to admit it.
When a second couple is found Jericho makes the connection that both couples visited the cinema on the evening of their deaths. They also found an 'English Maiden' card in the husband's jacket. But the smog is at it's worst and until it begins to clear the investigators are stranded at the Yard.
It's the night of the 'Widows and Orphans' fundraiser at Scotland Yard and Jericho, now star of the new TV series Jericho of The Yard, is meant to be making a speech. But just before the event he reads an article in the paper about his father, labelling him corrupt. Jericho is furious but his mother confirms that it's all true -- after the war his father returned home a cruel man and turned to corruption. She had never told Jericho this because she had wanted him to think the best of his father.
An old man arrives at the Yard proclaiming himself to be 'The Butcher' -- he is soon revealed as a crank but provides a vital insight into the murders. The violence and style of the killings leads them to believe that the murderer could have been a POW in the Far East during World War II. But why now? What could be motivating the killer thirteen years after his return? What's bringing it all back? What's playing at the cinema? The Bridge on The River Kwai -- which is currently being touted round town as the greatest film ever made.
The owner of the cinema, Mills, spent eighteen months on the Burma railway and did three years in prison for attempted rape.
Jericho and his men raid the cinema and discover Mills with Karen and Bette (two usherettes) and Ben, the projectionist. They are making a pornographic film with Karen starring. Karen has always wanted to be a Hollywood star and Mills persuaded her that this film would be her first step. Ben has been having a tentative relationship with Karen and is furious that Mills persuaded her to do this. It is discovered that 'English Maiden' is a night that Mills runs, which shows pornographic films on a makeshift screen in his office.
Mills is arrested for the murders of the two couples. Although he pleads his innocence Mills seems to clearly understand the psychology of the crime. Is he protecting someone? Jericho allows Mills to hold his 'English Maiden' night so that they can see who turns up. Pickering arrives and tries to attack Mills with a knife. He believes Mills to be the killer and is seeking revenge for the deaths of Diana and Marcus.
It's the morning of Caldicott's wedding and he's still at the cinema taking statements from the men at the English Maiden night. Out of the corner of his eye he sees Mills behaving suspiciously and decides to follow him. He finds Mills having an argument with Ben and Karen. In the heat of the argument Ben reaches for a knife Karen had been using to make sandwiches and stabs Mills to death.
Back at the Yard Jericho discovers that Ben served with Mills in Singapore and was also a POW in Burma. Harvey and Jericho rush to the cinema to find Caldicott being held at knifepoint. Jericho manages to talk Ben down. After the war Ben just wanted to be normal, but he had a terrible problem with intimacy -- he couldn't bear to be touched. Mills gave him the job at the cinema, wanting to look after him. But it meant that Ben would watch all these young couples in the back seats of the cinema, kissing and cuddling, and it drove him insane with jealousy and anger.
They rush Caldicott to the church who arrives just on time for his wedding as the smog begins to lift over the city.
Jericho gets a call from Juliette -- she's in Paris -- and suggests that he should come over to France for a holiday... He's clearly tempted...


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VIA Rail Easter Results: Sweet
HIGHLIGHTS From Thursday, March 28 th to Tuesday, April 2 nd:
ROUTES BETWEEN QUEBEC, MONTRÉAL, OTTAWA AND TORONTO | Increase in ridership of 10.2% compared to 2012 Increase in revenues of 4.9% compared to 2012
COAST-TO-COAST VIA RAIL NETWORK | 71,000 passengers on-board Increase in ridership of 2.4% compared to 2012 Train Occupancy up 6.9 percentage points compared to 2012
MONTREAL, April 5, 2013 /CNW Telbec/ - VIA Rail Canada is reporting a busy Easter holiday weekend. Motivated by their desire to travel efficiently and seamlessly, more Canadians chose to travel aboard VIA Rail trains during the Easter weekend, compared to last year. Between this past March 28 th and April 2 nd, 71,000 passengers traveled on some 450 trains throughout the country, an increase of 2.4% compared to 2012.
These results show that, in Canada, train is a mode of transport that is growing in popularity. "VIA Rail is implementing several initiatives to improve passenger comfort and facilitate their intercity mobility", said Marc Laliberté, President and Chief Executive Officer of VIA Rail. "The results of last weekend demonstrate that we are moving in the right direction." Dynamism | Performance | Popularity On the coast-to-coast network, the busiest day was Thursday, March 28 th, when 15,000 passengers boarded trains. Several trains showed an occupancy rate of over 95%. VIA Rail customers made good use of trains in the Quebec City-Montréal- Ottawa- Toronto corridor, which proved the most popular over the long weekend, registering an increase of 10.2% in ridership and 4.9% in revenues compared to the same period in 2012. On longer-distance services, the most popular segments were Toronto- Vancouver, Edmonton- Vancouver and Jasper- Vancouver ( The Canadian), as well as Halifax-Montréal, Moncton-Montréal and Bathurst-Montréal ( The Ocean). Performance on these services improved significantly: revenue per passenger increased by 13.2%. On social media, faithful to their habit, VIA Rail customers sent many comments about the quality of customer service and the future On-Board Entertainment programming. A total of 1,630 messages were posted on VIA Rail's Twitter and Facebook pages during the Easter break. Moreover, a great number of customers on trains comfortably connected to VIA Rail's on-board Wi-Fi, and transferred some 1.53 gbytes of data, the equivalent of some 1.5 million emails. About VIA Rail Canada As Canada's national rail passenger service, VIA Rail Canada's mandate is to provide safe, efficient and economical passenger transportation service, in both official languages of our country. VIA operates intercity, regional and transcontinental trains linking 450 communities across its 12,500-kilometre route network. Recipient of the Railway Association of Canada's Safety Award in 2011 for the 11 th time in 12 years, and of the 2012 Agent's Choice Award voted by Canadian travel agents and presented by Baxter Travel Media, VIA safely transports nearly four million passengers annually. Since 2007, the Government of Canada has invested almost a billion dollars in VIA Rail. Follow the progress of our transformation at http://www.viarail.ca/en/about-via-rail/capital-investment. Follow us on our Evolution Blog at viaevolution.ca - on Twitter @VIA_rail - on Facebook. SOURCE VIA Rail Canada Inc.Check Out Our Best Services for Investors
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Cost of Diabetes: Reyes family portraits Previous Next Michael Zamora/Caller-Times Samantha Reyes, 14 (from left), sits with mother Danita Reyes and twins Simon and Sophie Reyes, 10, next to a vase of flowers meant for Mike Reyes' gravesite. After years of complications from diabetes, Mike Reyes, a father and husband, died after having a heart attack. Corpus Christi Caller-Times Michael Zamora/Caller-Times Sophie Reyes, 10 (from left), looks down at a memorial blanket with her father's image as sister Samantha Reyes, 14, and twin brother, Simon, talk with their mother Danita Reyes at their home in Corpus Christi. The Reyes family offers a stark but familiar portrait about the consequences of a disease too few take seriously. Corpus Christi Caller-Times Michael Zamora/Caller-Times Simon, 10, and Danita Reyes finish their neighborhood walk recently at their home in Corpus Christi. Danita Reyes says she is encouraging her son to be more active after his father, Mike Reyes, died in March following years of diabetes complications including kidney failure, blindness and a stroke. Corpus Christi Caller-Times Michael Zamora/Caller-Times Danita Reyes sits on the bed where she keeps her memorial blanket for her husband, Mike Reyes, who died after suffering cardiac arrest during dialysis. Mike, 38, was diagnosed with diabetes at 23. Corpus Christi Caller-Times Show Caption Hide Caption


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22-15920 - Pliers Storage Rack
Pliers storage rack makes a handy storage solution for any work bench or tool chest. Keeps up to 32 pairs of pliers organized but ready for work.
MCM Cat 57, Page 718
MCM Cat 56, Page 648


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Secret garden bridal hair pins (set of 7)
Available now!
Secret garden bridal hair pins by Emmy
This set of flower bridal hair pins by Emmy are simply lovely. Delicately detailed with dainty blush and ivory beads, these are perfect for complementing a subtle bohemian or vintage inspired bridal look.
Scatter through hair to build interest and detail, or share these wedding hair pins among your bridesmaids.
3 large and 4 small per set.
Please note: the first 3 model images show the model wearing two sets of hair pins (in model image 1) and with smaller crystal pins and veil (in model images 2 & 3). Model image 4 shows a single set of 7 pins worn in a cluster.
Diameter of detail: 4cm (on large), 3cm (on small).
Standard UK delivery | FREE on orders £100 & over or £3.95 on orders under £100 | 3-5 working days |
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Under our Returns Policy, we are happy to accept the return of unsuitable items providing they are returned in original condition and packaging within 14 days of receipt.
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Items where Author is Higgitt, D.L.
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ArticleYeloff, D.E. and Labadz, J.C. and Hunt, C.O. and Higgitt, D.L. and Foster, Ian D.L. (2005) Blanket peat erosion and sediment yield in an upland reservoir catchment in the southern Pennines, UK. Earth Surface Processes and Landforms, 30 (6). pp. 717-733. ISSN 0197-9337 |


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Hi guys I seen this kit just sell on ebay for 169.00 and could not believe it . I thought I could maybe get it for 60.00-70.00 ,but that wasn't going to happen
So I did some research and found out it is 1972 GTO with a hood scoop from the Grumpy's toy Camaro and a set of decals . So I decided I wanted to build it so I drew the decals and found a scoop in the junk box and went out and bought a new 1972 GTO kit ,here are the decals and a couple other old ones I want to build
enjoy the pics Chuck


text: We met Borja at the fountain at plaza nueva & took off for a great tour of the " old city" . Borja was enthusiastic & very knowledgeable about his adopted city. He was also very responsive to the questions being asked of him & showed us some areas I knew nothing about. The views were amazing! He has some... More


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Monday, March 29
Digital Domain Park - Port St. Lucie, FL
Attendance: 2,950
Port St. Lucie, FL (Sports Network) - Jeff Francoeur went 3-for-4 and scored three times as the New York Mets beat the Florida Marlins, 7-6, in Grapefruit League play.
Henry Blanco was 2-for-4 with two runs batted in, while Mets starter Jon Niese also drove in two. On the mound, Niese gave up four runs (three earned) on six hits and three walks in 4 2/3 innings, while striking out three.
Marlins starter Anibal Sanchez was pounded for seven runs on nine hits and three walks in 4 2/3 frames. He gave up five of those runs in the second inning. Jorge Cantu was 2-for-2 with two RBI to lead Florida's offense.
Tyler Funneman
Ed Hickox
Justin Vogel
James Hoye