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| TNF-alphaSummaryGene Symbol: TNF-alpha Description: tumor necrosis factor Alias: DIF, TNF-alpha, TNFA, TNFSF2, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha Species: human Top Publications
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- TNF-alpha induces two distinct caspase-8 activation pathwaysLai Wang
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Cell 133:693-703. 2008..These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP... - The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activationH Hsu
Tularik, Incorporated, South San Francisco, California 94080, USA
Cell 81:495-504. 1995..However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct... - Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alphaM L Moss
Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
Nature 385:733-6. 1997..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production... - Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexesOlivier Micheau
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Cell 114:181-90. 2003..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated... - The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cellsAya Shiraki
Saga University Faculty of Medicine Department of Cardiovascular and Renal Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
Atherosclerosis 221:375-82. 2012..However, the effects upon endothelial cells and the mechanisms involved are not fully understood. We assessed the hypothesis that GLP-1 has protective effects against inflammation and oxidative stress on human endothelial cells... - TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosisAdam P Gregory
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
Nature 488:508-11. 2012..Hence, our study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation... - Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon populationHivana Patricia Melo Barbosa
Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
World J Gastroenterol 15:1465-71. 2009..To study the association between Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha polymorphisms, infection by Helicobacter pylori (H pylori) and the development of gastrointestinal diseases... - HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cellsElena Martinelli
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:3396-401. 2007.... - Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese populationWanli Lu
Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
Carcinogenesis 26:631-6. 2005..to assess the association between genetic polymorphisms in interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha (TNFalpha), which are involved in H.pylori infection, and risk of gastric cancer... - Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's diseaseMateusz Dezor
Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland
Folia Neuropathol 49:123-31. 2011..It is possible that OGG1 and p53 and TNF-α proteins together or separately may be involved in pathogenesis of AD by repair of oxidative DNA damage and/or apoptosis... - Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transitionGali Soria
Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
BMC Cancer 11:130. 2011..In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course... - Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alphaSinead M Flannery
School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
J Biol Chem 286:23688-97. 2011..Collectively, these data demonstrate for the first time an essential role for IRAK-2 in primary human cells for both transcriptional and post-transcriptional TLR responses... - Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populationsTaane G Clark
Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
J Infect Dis 199:569-75. 2009..Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms... - Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptorsS Muller
German Diabetes Clinic, German Diabetes Research Institute at the University of Düsseldorf, Dusseldorf, Germany
Diabetologia 45:805-12. 2002..A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance... - IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) familyH Wesche
Tularik Inc, South San Francisco, California 94080, USA
J Biol Chem 274:19403-10. 1999..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family... - c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expressionWei Chien Huang
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
J Biol Chem 278:9944-52. 2003..These two pathways converge at IKKbeta and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate ICAM-1 expression... - Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in KoreaJa Young Lee
Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University Medical Center, 445, Kildong, Kangdong gu, Seoul 134 701, South Korea
Cancer Lett 225:207-14. 2005..pylori infection status, location of GC, and histologic type of GC. In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea... - Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signallingJason S Rockel
Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A5C1, Canada
Arthritis Res Ther 11:R8. 2009..TNFalpha activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFalpha-regulated gene expression in chondrocytes is unknown... - Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activationYihui Fan
Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
J Biol Chem 285:5347-60. 2010Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) and c-Jun N-.. - Systemic cytokine response in patients with community-acquired pneumoniaH Endeman
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
Eur Respir J 37:1431-8. 2011..IL-1RA, IL-6, IL-8 and IL-10 are acute phase proteins, independent of genotype. Their levels are influenced by the nature of the causative microorganism and the start of corticosteroids therapy... - Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1Maria J Smolinska
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Oxford University, London W6 8LH, United Kingdom
J Immunol 187:6043-51. 2011..These data highlight the importance of Hck as an active component in LPS-induced TLR signaling and suggest the possibility of targeting this kinase for the alleviation of excessive inflammation... - Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cellsMostafa A Gabr
Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA
J Orthop Res 29:1-7. 2011..IL-17 may be an important regulator of inflammation in the IVD pathologies... - The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndromeSilvia Sookoian
Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
Am J Hypertens 18:1271-5. 2005..We investigated the possible contribution of the G-308A TNF-alpha mutant to explain variables of the metabolic syndrome... - Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriersK Tsukasaki
Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
Cancer Res 61:3770-4. 2001..and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor necrosis factor alpha (TNF-alpha) using PCR-based genotyping assays... - IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytesArnaud Hot
Department of Clinical Immunology and Rheumatology and Immunogenomics and Inflammation Research Unit, Hopital Edouard Herriot, University of Lyon 1, Lyon, France
Ann Rheum Dis 71:1393-401. 2012..To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness... - Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-αRebecca K Studer
VA Pittsburgh, Pittsburgh, PA, USA
Spine (Phila Pa 1976) 36:593-9. 2011..CONCLUSION.: The results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-α, thus, helping preserve disc composition, structure, and function... - Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cellsTyler C Thacker
Department of Chemistry and Biochemistry, Room C 211A BNSN, Brigham Young University, Provo, UT 84602, USA
J Virol 83:150-8. 2009..FDCs produced soluble tumor necrosis factor alpha (TNF-alpha) ex vivo, and the addition of a blocking soluble TNF receptor ablated FDC-mediated HIV .. - The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10Ana Carolina F Motta
Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
Braz Dent J 21:158-64. 2010..05). These results suggest that oral infection could be involved as a maintenance factor in the pathogenesis of leprosy reactional episodes... - Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)Sophie Limou
Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
J Infect Dis 199:419-26. 2009..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection... - PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cellsKonstantin Tsoyi
Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
Atherosclerosis 213:115-21. 2010..It is concluded that PTEN selectively inhibits expression of VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3β/GATA-6 signaling cascade in TNF-α-treated ECs... - Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticlesDanielle B Peterson
Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
Proteomics 8:2430-46. 2008..These observations provide fundamental insight into the mechanisms regulating the production of these particles and their physiological role in numerous diseases... - Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activationMohamed Hassan
Department of Dermatology, Faculty of Medicine, University of Duesseldorf, Mooren Strasse 5, 40225 Duesseldorf, Germany
Cell Signal 19:301-11. 2007..patients is associated with the production of serum and interhepatic inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha)... - Cytokine gene polymorphism in sympathetic ophthalmiaDenize Atan
Academic Unit of Ophthalmology, Clinical Sciences South Bristol, Bristol Eye Hospital, UK
Invest Ophthalmol Vis Sci 46:4245-50. 2005..The purpose of this study was to determine whether polymorphisms in the cytokine genes are important markers for disease severity and outcome in patients with SO... - TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosisYoude Jiang
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Cell Signal 24:1086-92. 2012..Resolution of the hyperglycemia-induced TNFα levels in retinal endothelial cells may prevent apoptosis through disinhibition of insulin receptor signaling... - TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosisIoanna Tsagaraki
Institute of Biology, National Center for Scientific Research Demokritos, 15310 Agia Paraskevi, Athens, Greece
Cell Tissue Res 342:87-96. 2010..The biological role of this interaction was revealed by the use of echistatin, an antagonist of αvβ3 integrin. In the presence of echistatin, decreased protection against apoptosis by recombinant TIMP-1 was observed... - Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancerChuen Ming Shih
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
Lung Cancer 52:15-20. 2006.... - Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteasesThorsten Hagemann
Department of Haematology Oncology, Georg August University, Gottingen, Germany
Carcinogenesis 25:1543-9. 2004..In summary, we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to TNF-alpha dependent MMP induction in the macrophages... - Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathwaysFabrizio Montecucco
Laboratory of Phagocyte Physiopathology, First Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa Medical School, Genoa, Italy
Cell Signal 20:557-68. 2008..Although highly speculative, ERK 1/2 p44 may represent a selective target for the pharmacologic manipulation of neutrophil-mediated adverse activities in TNF-alpha-mediated inflammatory states... - Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cellsPaul D Upton
Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge CB2 2QQ, UK
J Biol Chem 284:15794-804. 2009..This differential signaling may contribute to the contrasting pathologies of hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension... - S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2Jin Zhang
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
J Biol Chem 283:35375-82. 2008..We present a new mechanism for TNF-alpha to induce insulin resistance that involves activation of S6K by an IKK2-dependent pathway. S6K directly phosphorylates IRS-1 on multiple serine residues to inhibit insulin signaling... - TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patientsSandra A Drigo
Heart Institute InCor, School of Medicine, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar 44, Bloco 2, 9 andar, CEP 05403 001 São Paulo, Brazil
Microbes Infect 8:598-603. 2006..We typed the TNFa microsatellite and the -308 TNF promoter polymorphism and then analyzed the survival curves of 42 patients with .. - Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicityLara Buscemi
Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
Neurobiol Dis 26:661-70. 2007.... - The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa BS Bour
Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 276:15920-8. 2001..However, in the presence of Vpu, this HIV-mediated NF-kappaB activation was markedly reduced. These results suggest that Vpu modulates both virus- and cytokine-induced activation of NF-kappaB in HIV-1-infected cells... - Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric populationSilvia Jiménez-Morales
Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, SS, Mexico City, Mexico
Hum Immunol 70:251-6. 2009..89, p = 0.004). These results support the concept that the TNF-alpha gene is a genetic risk factor for asthma, SLE, and JRA in the pediatric Mexican population... - Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birthMargaret F Annells
Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
Am J Obstet Gynecol 191:2056-67. 2004..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense... - Association of tumor necrosis factor alpha gene polymorphism G-308A with pseudoexfoliative glaucoma in the Pakistani populationMuhammad Imran Khan
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
Mol Vis 15:2861-7. 2009The purpose of the present study was to determine the role of the tumor necrosis factor alpha (TNF-alpha) gene polymorphism G-308A and total serum immunoglobulin E (TsIgE) levels in the onset of pseudoexfoliation glaucoma (PEXG) in .. - TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophySwarnali Acharyya
Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 5:e12479. 2010..This regulation coincides with elevated levels of muscle derived TNFalpha that is also under IKKbeta and NF-kappaB control... - Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sitesStephen J Wort
Department of Critical Care, National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
J Biol Chem 284:24297-305. 2009..synergistic induction of preproET-1 message RNA and release of mature peptide by a combination of tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) in primary human pulmonary artery smooth muscle cells... - Autoimmunity and tuberculosis. Opposite association with TNF polymorphismPaula A Correa
Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia
J Rheumatol 32:219-24. 2005.... - Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naïve monocytes to produce TNF-alpha through cellular cross-talkHang Xie
Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
Cell Microbiol 10:1453-67. 2008..These results suggest that M. catarrhalis LOS could induce excessive middle ear inflammation through a cellular cross-talk mechanism during OME... - IL1RN polymorphic gene and cagA-positive status independently increase the risk of noncardia gastric carcinomaGifone Aguiar Rocha
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Int J Cancer 115:678-83. 2005..Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-alpha (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in a non-Caucasian .. - Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai populationP Kummee
Inter Department of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand
J Viral Hepat 14:841-8. 2007..Additional study is needed to validate these finding and to further explore the genetic pathogenesis of HBV infection... - Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucomaMohammad Reza Razeghinejad
Department of Ophthalmology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
Ophthalmic Res 42:118-24. 2009..Therefore, the association of single nucleotide polymorphisms in the TNFRI gene and the promoter region of the TNFA gene with glaucoma susceptibility was investigated in the present study. - Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscleMiranda D Grounds
School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia
Clin Exp Pharmacol Physiol 35:846-51. 2008.... - Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and diseaseMaqsood M Elahi
Department of Human Sciences, Human Genetics Laboratory, Loughborough University, Leicestershire, UK
Biochim Biophys Acta 1792:163-72. 2009..This review discusses the genetics of the TNF-alpha -308 polymorphism in selected major diseases and evaluates its common role in health and disease... - Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathwaysXianghuai Lu
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Decatur, Georgia 30033, USA
J Biol Chem 281:6297-306. 2006..The inhibitory effect of TNF on Osx expression may decrease OB differentiation in arthritis and osteoporosis... - Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytesSeong Su Nah
Division of Allergy and Rheumatology, Department of Internal Medicine, College of Medicine, University of Ulsan, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
FEBS Lett 581:1928-32. 2007..In conclusion, accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha... - The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanerceptLindsey A Criswell
Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
Arthritis Rheum 50:2750-6. 2004..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)... - Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuliChristos Tsatsanis
Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
Biochem Biophys Res Commun 335:1254-63. 2005..Our data suggest that adiponectin constant presence in the circulation in high levels (in lean subjects) renders macrophages resistant to pro-inflammatory stimuli, including its own... - A meta-analysis on the association between three promoter variants of TNF-α and Crohn's diseaseCui Xie
Laboratory of Disorder Genes and Department of Pharmacology, College of Pharmacy, Chongqing Medical University, 1 Yi Xue Yuan Road, P O Box 380, Chongqing 400016, People s Republic of China
Mol Biol Rep 39:1575-83. 2012..76) and GG (OR 0.92, 95% CI 0.70-1.21, P = 0.55) genotypes were associated with CD susceptibility, respectively. Our meta-analysis demonstrates that three promoter polymorphisms of TNF-α above may not confer susceptibility to CD... - Association of TNF-alpha promoter polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han populationT Du
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
J Viral Hepat 13:618-24. 2006..0001, P = 0.0004). In conclusion, TNF-alpha promoter polymorphisms are independently associated with different outcomes of HBV infection... - HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2Giorgio Mangino
Department of Biology, University Roma Tre, Rome, Italy
PLoS ONE 6:e22982. 2011.... - Cytokine polymorphism in noninfectious uveitisDenize Atan
Clinical Sciences at South Bristol, Bristol Eye Hospital, Bristol, UK
Invest Ophthalmol Vis Sci 51:4133-42. 2010..b>TNFA and IL10 are strong candidate genes, given the influence of these cytokines on inflammation, immune tolerance, and .. - c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activationEugene Varfolomeev
Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 283:24295-9. 2008..Therefore, c-IAP1 and c-IAP2 are required for TNFalpha-stimulated RIP1 ubiquitination and NF-kappaB activation... - Essential role of NF-κB and AP-1 transcription factors in TNF-α-induced TSLP expression in human airway smooth muscle cellsNaresh Singh Redhu
Dept of Immunology, Faculty of Medicine, Univ of Manitoba, Winnipeg, Canada
Am J Physiol Lung Cell Mol Physiol 300:L479-85. 2011..05; n = 3) in HASM. Collectively, our data suggest a novel important biological role for NF-κB pathway in TNF-α-induced TSLP expression in HASM and recommend this as a prime target for anti-inflammatory drugs... - Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysisOliver Teuffel
the Division of Haematology Oncology, Hospital for Sick Children, Toronto, Canada
Crit Care Med 38:276-82. 2010..We conducted a systematic review and meta-analysis to determine whether the TNF-alpha -308 A/G polymorphism TNF2 (G/A or A/A) confers susceptibility to sepsis or is associated with increased risk of death from sepsis... - Tumor necrosis factor alpha gene polymorphism is associated with the outcome of trauma patients in Chinese Han populationZhao Xia Duan
Department 6 of Research Institute of Surgery, Daping Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China
J Trauma 70:954-8. 2011..The purpose of this article was to research the clinical relevance of the TNF gene polymorphism in patients with major trauma... - Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytesYumie Takeshita
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
Eur J Pharmacol 579:426-32. 2008..Selective angiotensin AT(1) receptor antagonists inhibit both TNF-alpha- and angiotensin II-induced PAI-1 production in hepatocytes, suggesting a cross talk between both systems... - Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genesMaja Mustapic
Rudjer Boskovic Institute, Zagreb, Croatia
Metab Brain Dis 27:507-12. 2012..Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D... - Association of-238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infectionHong quan Li
Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, China
Biomed Environ Sci 19:133-6. 2006..To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-alpha) gene promoter were associated with outcomes of hepatitis B virus infection... - Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorderN Konuk
Department of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
Mediators Inflamm 2007:65704. 2007..The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in OCD patients... - Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms?Tariq Ahmad
Gastroenterology Unit, Gibson Laboratories, University of Oxford, Radcliffe Infirmary, Oxford, UK
Arthritis Rheum 48:807-13. 2003Experimental evidence suggests that inappropriate regulation of tumor necrosis factor alpha (TNF alpha) may play a role in the pathogenesis of Behçet's disease (BD)... - Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian IndiansReeshu Gupta
Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
Oral Oncol 44:455-63. 2008..These SNPs may be useful as a marker for high-risk groups among Asian Indians... - Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian populationRym Bouhaha
Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, 2092 Tunis, Tunisia
Clin Biochem 43:549-52. 2010..We investigated two genetic markers in pro inflammatory molecules : TNFalpha -308G/A and IL6 -174G/C in order to assess their effect on type 2 diabetes (T2D) and obesity in the Tunisian population... - Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusionMarina G Smirnova
Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Eur Cytokine Netw 13:161-72. 2002..In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion... - Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese menT Ishii
Department of Internal Medicine and Health Center, Keio University School of Medicine, Tokyo, Japan
Metabolism 49:1616-8. 2000In obese subjects, the levels of tumor necrosis factor alpha (TNF-alpha) expression and protein synthesis in adipocytes are increased... - Association between LTA, TNF and AGER polymorphisms and late diabetic complicationsEero Lindholm
Department of Clinical Sciences, University Hospital MAS, Lund University, Lund, Sweden
PLoS ONE 3:e2546. 2008..The aim of our study was therefore to explore whether polymorphisms (TNF -308 G-->A, LTA T60N C-->A and AGER -374 T-->A) in these genes alone or together (as haplotypes) increased the risk for diabetic complications... - Proinflammatory cytokines Il-6 and TNF-α and the development of inflammation in obese subjectsKatarzyna Popko
Department of Laboratory Diagnostics, Warsaw Medical University, Warsaw, Poland
Eur J Med Res 15:120-2. 2010..Both cytokines are the main factors responsible for the induction of acute phase proteins production (e.g., CRP) and to inflammatory state... - [The -308 and -238 Polymorphisms of the TNF-alpha Promoter Gene in Type 2 Diabetes Mellitus.]Hye Ryoun Kim
Department of Laboratory Medicine, Chung Ang University College of Medicine, Seoul, Korea
Korean J Lab Med 26:58-63. 2006.... - Tumor necrosis factor-alpha-308A allele may have a protective effect for chronic hepatitis B virus infection in Mongoloid populationsMing Hua Zheng
Department of Infection and Liver Diseases, Liver Research Center, First Affiliated Hospital of Wenzhou Medical College, No 2 Fuxue Lane, Wenzhou, Zhejiang, China
Int J Infect Dis 14:e580-5. 2010..Previous studies on the tumor necrosis factor-alpha (TNF-alpha)-308 gene promoter polymorphism in chronic hepatitis B virus (HBV) infection have reported conflicting results... - Haplotypes in the tumour necrosis factor region and myelomaGareth J Morgan
Section of Haemato oncology, Institute for Cancer Research, Royal Marsden Hospital, London, UK
Br J Haematol 129:358-65. 2005..308 and -238 of the 5' promoter region of TNF-alpha gene, and 252 in the LT-alpha gene; and five microsatellites, TNFa, b, c, d and e. Haplotypes were inferred statistically using the phase algorithm... - Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMOChee Kwee Ea
Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell 22:245-57. 2006..protein kinase 1 (RIP1) is essential for the activation of nuclear factor kappaB (NF-kappaB) by tumor necrosis factor alpha (TNFalpha)... - NRAMP1 and TNF-alpha polymorphisms and susceptibility to tuberculosis in ThaisSasijit Vejbaesya
Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Respirology 12:202-6. 2007..However, the results are inconsistent. This study aimed to determine whether NRAMP1 and TNF-alpha variants are associated with tuberculosis in Thais... - Lack of association between TNF 238 G/A polymorphism and type 2 diabetes: a meta-analysisRennan Feng
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Harbin, People s Republic of China
Acta Diabetol 46:339-43. 2009..18 (0.92-1.51) and 1.13 (0.62-2.04), respectively. This first meta-analysis of data from the current and published studies did not detect any association between the polymorphism of TNF 238 G/A and risk for T2D... - Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic feverOnder Ergonul
Infectious Diseases and Clinical Microbiology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
J Infect Dis 193:941-4. 2006..In conclusion, these findings demonstrate that proinflammatory cytokines play a major role in the mortality of patients with CCHF... - Allele 2 of the interleukin-1 receptor antagonist gene is associated with early gastric cancerJurgen Glas
Medizinische Poliklinik, Chirurgische Klinik und Poliklinik, Klinikum der Universitat Munchen, Standort Innenstadt, Germany
J Clin Oncol 22:4746-52. 2004..In early-stage gastric cancer, which we defined as adenocarcinoma confined to the mucosa or submucosa (stage T1), the role of host genetic susceptibility remains to be determined... - TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophagesFederica Alciato
Clinical Immunology, Department of Clinical and Experimental Medicine, Universita del Piemonte Orientale A Avogadro, Novara, Italy
J Leukoc Biol 87:869-75. 2010..Therefore, GAS6 modulates macrophage cytokine secretion, triggering an "anti-inflammatory pathway" involving PI3K/Akt/GSK3 beta and NF-kappaB... - Paget's disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genesLuis Corral-Gudino
Servicio de Medicina Interna, RETICEF, Hospital Universitario de Salamanca, Los Montalvos s n, Salamanca, Spain
Cytokine 52:146-50. 2010..Cytokines, specially interleukin (IL)-6, play an important role in the differentiation and activation of osteoclasts and might be involved in osteoblast stimulation in Paget's disease of bone (PDB)... - Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its componentsCatherine M Phillips
Nutrigenomics Research Group, University College Dublin School of Public Health and Population Science, University College Dublin Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
J Clin Endocrinol Metab 95:1386-94. 2010..Cytokine polymorphisms and dietary fat composition may influence the risk of the metabolic syndrome (MetS)... - TNF-alpha promoter single nucleotide polymorphisms in gastroenteropancreatic neuroendocrine tumorsMaja Berković
Department of Endocrinology, Diabetes and Metabolism, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Neuroendocrinology 84:346-52. 2006..The results suggest the putative role of TNF-alpha -1031 polymorphism in the development of GEP-NET... - Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetesVesna Boraska
Department of Medical Biology, University of Split School of Medicine, Split, Croatia
BMC Med Genet 11:69. 2010..The purpose of this study is to examine T2D association of tag SNPs in the TNF/LTA region capturing the majority of common variation in a large-scale sample set of UK/Irish origin... - Lack of association of tumor necrosis factor-alpha polymorphisms with Chagas disease in Brazilian patientsSandra A Drigo
Heart Institute InCor, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Immunol Lett 108:109-11. 2007..We analyzed the TNFa microsatellite and the -308 TNF promoter polymorphisms, in 166 CCC compared to 80 ASY geographically and age-.. - Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibilityYan Feng Zou
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, People s Republic of China
Autoimmunity 43:264-74. 2010..48 (95% CI = 0.30-0.75, P = 0.001) in Caucasian population. In conclusion, this meta-analysis demonstrates the association between TNF-alpha promoter - 238A/G polymorphism and SLE, especially in Caucasian population... - TNF and TNF receptor polymorphisms in Korean Behcet's disease patientsEun Bong Lee
Department of Internal Medicine, Clinical Research Institute, Human Genome Research Institute, Medical Research Center, Seoul, South Korea
Hum Immunol 64:614-20. 2003..In this study, we investigated genetic polymorphisms of TNF alpha -308 G/A, TNF beta +252 G/A, and TNFR2 196 R/M in 94 Korean BD patients and age- and sex-matched healthy .. - No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer diseaseM A Garcia-Gonzalez
Unidad Mixta de Investigación and Department of Gastroenterology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
Int J Immunogenet 32:299-306. 2005..to investigate possible allelic variant associations of several functional polymorphisms in the IL-1B, IL-1RN, TNFA, and LTA genes in the susceptibility to duodenal ulcer... - Profound bias in interferon-gamma and interleukin-6 allele frequencies in western Kenya, where severe malarial anemia is common in childrenIan S Gourley
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Infect Dis 186:1007-12. 2002..IFN-gamma and IL-6 genotypes may play roles in the development of severe malaria and could contribute to the relative frequency of severe malarial anemia or cerebral malaria in exposed populations... - TNFalpha-308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian populationIndu Kohaar
Division of Molecular Genetics and Biochemistry, Institute of Cytology and Preventive Oncology ICMR, I 7, Sector 39, Noida, India
Cell Oncol 29:249-56. 2007Investigation of the potential association of single nucleotide polymorphisms (SNPs) at -308 G/A and -238 G/A of Tumor necrosis factor alpha (TNFalpha) with susceptibility to HPV-16 associated cervical cancer in Indian women. - Polymorphisms of interleukin-6 and tumor necrosis factor gene promoters and cardiorespiratory function following liver transplantation: a preliminary studyJ Arranz Duran
Liver Transplant Unit, Hospital Universitario NS de Candelaria, Tenerife, Spain
Transplant Proc 41:1062-4. 2009..The interindividual variability in cardiorespiratory function during liver transplantation (OLT) has been attributed to various factors, including polymorphisms in immunity genes known to affect the circulation levels of cytokines... - TNF 308 G/A polymorphism and type 1 diabetes: a meta-analysisRen Nan Feng
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin 150086, China
Diabetes Res Clin Pract 85:e4-7. 2009..Eleven reports were identified. Our study confirmed that a higher frequency of TNF 308 A allele conferred a significant risk for T1DM. Potential explanations were discussed... - Comparison of serum concentrations of C-reactive protein, TNF-alpha, and interleukin 6 between elderly Korean women with normal and impaired glucose toleranceK M Choi
Department of Internal Medicine, Korea University Guro Hospital, 80 Guro dong, Guro Gu, Seoul 152 050, South Korea
Diabetes Res Clin Pract 64:99-106. 2004..was performed to compare concentrations of pro-inflammatory cytokines, such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) as well as acute-phase protein, such as C-reactive protein (CRP) between subjects with .. - The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control studyJae Jeong Yang
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
BMC Cancer 9:238. 2009..The aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population...
Research Grants
- Gene Polymorphism, Infection/Inflammation, Preterm BirthXiaobin Wang; Fiscal Year: 2010..VI. Maternal Questionnaire VII. Medical Record Abstraction Sheet PHS 398 (Rev. 4/98) (Form Page 3} Page 4 Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
- Interactions among Depressive Symptoms and Genetic Influences on Cardiac OutcomesLorraine Q Frazier; Fiscal Year: 2010..Inflammatory proteins and genes measured include: Interleukin (IL) 6, C-reactive Protein (CRP), Tumor Necrosis Factor Alpha (TNF?), E-Selectin (SELE), and Monocyte Chemoattractant Protein-1 (MCP-1)...
- Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in DepressionJill M Goldstein; Fiscal Year: 2011..An understanding of the fetal mechanisms associated with sex differences in MOD will have etiologic imolications and imoortance for the development of sex-specific treatments and prevention of MOD. ..
- DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASEFrank B Hu; Fiscal Year: 2013....
- PARP-1 in Juvenile Idiopathic Arthritis-associated IL-10 Promoter PolymorphismsJianguo Liu; Fiscal Year: 2010....
- Phenotyping Major Depression with Increased InflammationAndrew H Miller; Fiscal Year: 2013..abstract_text> ..
- Phenotyping Major Depression with Increased InflammationAndrew H Miller; Fiscal Year: 2010....
- Pathogenesis of Postoperative Cognitive DysfunctionZhongcong Xie; Fiscal Year: 2013..This proposal aims to investigate an understudied topic in an innovative system by testing novel hypotheses. Our efforts would ultimately lead to safer surgical care and better post-operative outcomes for senior patients. ..
- Regulation of IL-6 mediated inflammation and tissue destruction by EGCGSalah Uddin Ahmed; Fiscal Year: 2013..Successful completion of this study will lay the foundation for testing EGCG as a treatment option for RA and other inflammatory diseases. ..
- TNF Alpha in PKC Epsilon Signaling to CarcinogenesisAjit K Verma; Fiscal Year: 2013..development of squamous cell carcinoma (SCC) via increased expression of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF1) and granulocyte colony-stimulating factor (G-CSF) which may directly promote the proliferation ..
- Can Lifestyle Modify Fatigue in Breast Cancer Survivors?Wendy Y Chen; Fiscal Year: 2010....
- The Role of Mast Cells in the Pathophysiology of Intracranial AneurysmTomoki Hashimoto; Fiscal Year: 2013..This study will be a basis for future studies to test pharmacological therapies that target mast cells or mast cells-derived cytokines for the prevention of aneurysmal subarachnoid hemorrhage. ..
- Persistent COMT-dependent Pain: Role of beta-adrenergic ReceptorsANDREA G NACKLEY NEELY; Fiscal Year: 2012..g., beta2- and beta3ARs) for development of effective therapies for patients with persistent pain conditions.]] ..
- Persistent COMT-dependent Pain: Role of beta-adrenergic ReceptorsANDREA G NACKLEY NEELY; Fiscal Year: 2013..g., beta2- and beta3ARs) for development of effective therapies for patients with persistent pain conditions.]] ..
- Mutagenetic analysis of LPS responsesBruce Beutler; Fiscal Year: 2009..This work will enrich our understanding of how and why infections are sometimes lethal. ..
- Mutagenetic analysis of LPS responsesBRUCE A BEUTLER; Fiscal Year: 2010..This work will enrich our understanding of how and why infections are sometimes lethal. ..
- ADAM17 in pancreatic cancer and pancreatitisHoward C Crawford; Fiscal Year: 2013..In Aim 3, we will use pharmacological inhibition of ADAM17 released cytokines tumor necrosis factor alpha (TNFa) and interleukin 6 receptor (IL6R) to test for their influence on the etiology of pancreatic ..
- Genetic Regulation of Indoleamine-2,3-dioxygenase and Psychiatric Complications oGregory F Oxenkrug; Fiscal Year: 2010..HEALTH RELEVANCE: The proposed study aims to investigate whether analysis of cytokine gene polymorphisms might help to identify hepatitis C patients with high risk of developing psychiatric complications in response to IFN-alpha therapy ..
- Optoid Analgesics: Modulation of Trigeminal & Spinal Glial ActivationLinda Watkins; Fiscal Year: 2010..If successful, these studies will lead to development of novel adjunct therapies for improving clinical pain control by controlling the negative consequences of opioid-induced glial activation. ..
- Optoid Analgesics: Modulation of Trigeminal & Spinal Glial ActivationLinda Watkins; Fiscal Year: 2009..If successful, these studies will lead to development of novel adjunct therapies for improving clinical pain control by controlling the negative consequences of opioid-induced glial activation. ..
- The role of the inflammatory response in bone and cartilage changes following nonBLAINE ANDREW CHRISTIANSEN; Fiscal Year: 2013..During the mentored period I will successfully transition from the mentored stage of my career to an independent investigator. ..
- Pathogenesis and Therapy of HIV-Related Neuropathic PainShuanglin Hao; Fiscal Year: 2010..through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (TNF1) from dorsal root ganglion (DRG) neuron;and 2) activate glia to release TNF1...
- 3D Culture of Adipose Tissue for Screening Obesity-related DrugsKacey G Marra; Fiscal Year: 2010....
- Pathogenesis and Therapy of HIV-Related Neuropathic PainShuanglin Hao; Fiscal Year: 2010..through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (TNF1) from dorsal root ganglion (DRG) neuron;and 2) activate glia to release TNF1...
- Impact of Ambient Ultrafine Particle Exposures on Alzheimer's Disease ProgressionMICHAEL KERRY O'BANION; Fiscal Year: 2013..The findings will have profound implications for public health policy and will enable the development of therapeutic interventions for this debilitating and costly disease. ..
- Interactions among Depressive Symptoms and Genetic Influences on Cardiac OutcomesLorraine Q Frazier; Fiscal Year: 2010..Inflammatory proteins and genes include: Interleukin (IL) 6, C-reactive protein (CRP), Tumor Necrosis Factor Alpha (TNFa), E-Selectin (SELE) and Monocyte Chemoattractant Protein-1 (MCP-1)...
- Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical SiteStephen P Peters; Fiscal Year: 2013..Companion protocols will examine corticosteroid resistance (RASS) and a possible genetic mechanism for resistance (IMMOST) in adults, and the efficacy of inhaled S-nitrosoglutathione (N30-201) (SNORT) in children. ..
- Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical SiteWILLIAM GERALD TEAGUE; Fiscal Year: 2010..Companion protocols will examine corticosteroid resistance (RASS) and a possible genetic mechanism for resistance (IMMOST) in adults, and the efficacy of inhaled S-nitrosoglutathione (N30-201) (SNORT) in children. ..
- Mechanisms of hepcidin effects in the anemia of chronic diseaseRobert T Means; Fiscal Year: 2013..The proposed studies can potentially lead to an enhanced understanding of the mechanisms of ACD, and therefore to more effective therapy. ..
- Mechanisms of hepcidin effects in the anemia of chronic diseaseRobert T Means; Fiscal Year: 2011..The proposed studies can potentially lead to an enhanced understanding of the mechanisms of ACD, and therefore to more effective therapy. ..
- The Role of Decidual Innate Immunity in the Pathogenesis of PreeclampsiaSe Te Joseph Huang; Fiscal Year: 2010..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
- The Role of Decidual Innate Immunity in the Pathogenesis of PreeclampsiaSE TE HUANG; Fiscal Year: 2009..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
- The Role of Decidual Innate Immunity in the Pathogenesis of PreeclampsiaSe Te Joseph Huang; Fiscal Year: 2010..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
- Inhibition of bone formation by Prx1Mark S Nanes; Fiscal Year: 2013..Understanding this mechanism will allow us to find new medications that stimulate new bone formation and regeneration of tissue in veterans who suffer from arthritis, aging, and menopause associated fractures. ..
- Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and PreventionTed A Bateman; Fiscal Year: 2013..early inflammatory response to radiation damage) of osteoclasts via the cytokines tumor necrosis factor-alpha (TNFa) and interleukin-1 (IL-1)...
- Abnormal Bone Marrow Cells and Diabetic NeuropathyLawrence Chan; Fiscal Year: 2010..We will study the molecular and cellular mechanisms involved in these processes and events. ..
- Abnormal Bone Marrow Cells and Diabetic NeuropathyLawrence Chan; Fiscal Year: 2010..We will study the molecular and cellular mechanisms involved in these processes and events. ..
- Abnormal Bone Marrow Cells and Diabetic NeuropathyLawrence Chan; Fiscal Year: 2010..We will study the molecular and cellular mechanisms involved in these processes and events. ..
- Mindfulness Based Stress Reduction as an Adjunctive Treatment for PsoriasisJan A Moynihan; Fiscal Year: 2010....
- Mindfulness Based Stress Reduction as an Adjunctive Treatment for PsoriasisJan A Moynihan; Fiscal Year: 2013....
- Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and PreventionTed A Bateman; Fiscal Year: 2011..early inflammatory response to radiation damage) of osteoclasts via the cytokines tumor necrosis factor-alpha (TNFa) and interleukin-1 (IL-1)...
- Control of Drug Delivery to the CNS: Modulating P-glycoprotein ActivityWilliam A Banks; Fiscal Year: 2013..P-gp at the brain endothelial cell is inhibited by lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF)...
- Nebraska/Kansas Blood and Marrow Transplant Research NetworkJULIE MARIE VOSE; Fiscal Year: 2013..endothelial growth factor (VEGF), soluble Interleukin-2 receptor (slL2r), lnterleukein-12 (ILI 2), and tumor necrosis factor alpha (TNFa) in the post transplant period and correlate the results with the event-free survival (EFS) and ..
- The biology of blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2013..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
- The biology of blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2010..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
- Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseCraig J McClain; Fiscal Year: 2010..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
- Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseCraig J McClain; Fiscal Year: 2012..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
- Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseCraig McClain; Fiscal Year: 2009..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
- Cyclic AMP, Cytokine Modulation and Alcoholic Liver DiseaseCraig J McClain; Fiscal Year: 2013..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
- MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETESDAVID ANTONETTI; Fiscal Year: 2010..Further, the proposal will explore the link between vascular permeability and angiogenesis and the role of the tight junction protein occludin in endothelial cell growth control. ..
- MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETESDAVID ANTONETTI; Fiscal Year: 2012..Further, the proposal will explore the link between vascular permeability and angiogenesis and the role of the tight junction protein occludin in endothelial cell growth control. ..
- MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETESDAVID ANTONETTI; Fiscal Year: 2013..Further, the proposal will explore the link between vascular permeability and angiogenesis and the role of the tight junction protein occludin in endothelial cell growth control. ..
- Dichotomous Roles of Thrombin in Acetaminophen HepatotoxicityROBERT ANDREW ROTH; Fiscal Year: 2010..The proposed studies are designed to understand the mechanisms behind these dichotomous roles, and the results could lead to improved therapy and survival for patients with acetaminophen overdose. ..
- Role of FA protein complexes in hematopoiesisQishen Pang; Fiscal Year: 2009..to protect cells from cytotoxicity induced by combinations of either interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) or double-stranded RNA (dsRNA) and IFN-gamma...
- Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain BarrierMark R Opp; Fiscal Year: 2012..These sleep problems before the onset of sepsis are compounded by the severe sleep disruption that occurs while patients are in the ICU. ..
- Opioidergic System: Its Role(s) in GlaucomaShahid Husain; Fiscal Year: 2010..Hence there is a need to develop neuroprotective strategies to prevent vision loss in the glaucomatous individual. ..
- Negative regulation of NF-kB and inflammation by TAX1BP1Edward W Harhaj; Fiscal Year: 2010..This proposal will provide mechanistic insight into how TAX1BP1, Itch and A20 function together to inactivate key signaling molecules and restrict inflammatory signaling pathways. ..
- Dichotomous Roles of Thrombin in Acetaminophen HepatotoxicityROBERT ANDREW ROTH; Fiscal Year: 2013..Elucidating mechanisms by which APAP-induced liver injury progresses is essential for defining novel strategies to prevent liver failure in patients and for the general understanding of the pathogenesis of drug-induced liver injury. ..
- Pathogenic Mechanisms of Shiga ToxinsVernon L Tesh; Fiscal Year: 2010..An improved understanding of how these toxins cause disease is necessary to formulate effective therapeutic agents to block disease progression. ..
- Adipokines in Hemodialysis PatientsSrinivasan Beddhu; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: If fat cells produce harmful proteins, therapy targeted towards decreasing the production of these proteins will ultimately decrease the morbidity and mortality in obese dialysis patients. ..
- Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver RegenerationKRISTEN ANDREA MITCHELL; Fiscal Year: 2010..Finally, this project provides an opportunity for undergraduates at Boise State University to participate in biomedical research and gain an appreciation of the complex regulatory mechanisms that govern regeneration. ..
- Opioidergic System: Its Role(s) in GlaucomaShahid Husain; Fiscal Year: 2013..Outcomes of this project will provide valuable leads in the discovery of more effective therapies that can delay or prevent vision loss associated with neurodegenerative diseases such as glaucoma. 5 ..
- Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain BarrierMark R Opp; Fiscal Year: 2013....
- Preeclampsia, IUGR and Hypertension: Targets for TreatmentJoey P Granger; Fiscal Year: 2013....
- Novel therapies in alcoholic hepatitis University of LouisvilleCraig J McClain; Fiscal Year: 2013....
- An androgen-regulated cytokine network controls prostate apoptosisJohn J Krolewski; Fiscal Year: 2013..Finally, Aim 3 tests the functional role of FLIP, determining if FLIP down-regulation can cooperate with pro- apoptotic cytokines to induce apoptosis and regression of normal prostate and PrCa in a murine model. ..
- Progranulin Intervention in Inflammatory Bowel DiseasesChuanju Liu; Fiscal Year: 2013....
- Epidemiology of Bone Loss in African MenJoseph M Zmuda; Fiscal Year: 2013..bone loss with age;4) determine if higher concentrations of pro-inflammatory biomarkers, interleukin-6, tumor necrosis factor alpha and c-reactive protein, are each associated with accelerated loss of trabecular and cortical bone;and 5)..
- The involvement of IL-12 and IL-27 in immunity to Mycobacterium tuberculosisCORY MICHAEL ROBINSON; Fiscal Year: 2013..We have proposed basic research into host immune responses during infection that could have implications in design of therapeutic strategies and vaccines. ..
- MicroRNAs in Endothelial Cell Activation.Yajaira Suarez; Fiscal Year: 2013..better understanding of the cellular and molecular mechanisms that control EC activation and may identify potential therapeutic strategies for the regulation of endothelial activation through modulation of miRNA activity! ..
- Analysis of Coding Variants Associated with Age-Related PhenotypesLAURA MARIE TONKS RAFFIELD; Fiscal Year: 2013..The proposed research will further my development as an independent investigator and give me valuable experience in the meaningful application of human genetics tools to aging research. ..
- Effect of Antiviral CNS Penetration on CSF/Blood Cytokines and Depression in HIVGlenn J Treisman; Fiscal Year: 2013..An insight into changes in CSF/blood pro-inflammatory cytokines associated with the CPE of ART may be helpful in developing HIV treatments that have an additional effect of improving mood. ..
- Role of Spiral Ligament Fibrocytes in Immune-Mediated Inner Ear DamageDavid J Lim; Fiscal Year: 2013....
- Loss of fat tissue and functional responses to exercise in older, obese adultsBarbara J Nicklas; Fiscal Year: 2012..force and power, intramyocellular lipid, and muscle gene and protein expression of interleukin-6 and tumor necrosis factor alpha);and 3) inflammatory activity of abdominal adipose tissue and circulating adipokines...
- Dietary Inflammatory Index and Risk of Cancer in WomenFRED KINYUY TABUNG; Fiscal Year: 2013..of systemic inflammation: high-sensitivity C- reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha receptor 2 (TNF[unreadable]- 2) at baseline...
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Checkpoints of TNF Gene RegulationAnne Goldfeld; Fiscal Year: 2012....


text:
Human remains found on vacant land in South Kohala | News
Title (Max 100 Characters)
Human remains found on vacant land in South Kohala
SOUTH KOHALA, HAWAII (HawaiiNewsNow)- Hawaii Island police
have initiated a coroner's inquest case in connection with human remains found
in South Kohala.
At approximately 5:30 p.m. Monday (March 10) detectives from the Area II
Criminal Investigations Section located human remains on vacant land between
Queen Kaʻahumanu Highway and Puako Beach Drive.
An autopsy has been ordered to determine the cause of death and the identity of
the deceased.
Copyright 2014 Hawaii News Now. All rights reserved.

subset: commoncrawl


text: A COLD COMING ON? GRAB A CAN OF RED GOLD FRESH SQUEEZED TOMATO JUICE. Red Gold Tomato Juice is Fresh Squeezed and not from concentrate. It provides 120% of the daily required Vitamin C and is a good source of vitamin A. So next time you feel a bit of a cold coming on, grab a can of Red Gold Tomato juice instead of the regular Orange Juice.


text:
Applewood Farm Winery 12416 McCowan Rd. Stouffville, ON (905) 642 - 4720
Applewood Farm offers a chance to get out and experience a real country farm, not far from home.
Fine Wine - Apples - Strawberries - Pumpkins - Gift Baskets - Petting Zoo
We are pleased to offer group tours and wine tasting upon request.
Stop by and check out our new "Apple Jack". Perfect for chilly nights around the fire. OUR WINERY REMAINS OPEN UNTIL CHRISTMAS. Stop by for a sample!!!
Our farm is now closed for the season. Thank you so much for a great 2014!!
It was so nice to see all of our regular customers with their families this season. It was also nice to meet new customers. Hoping to see your children grow too. We wish you all the best for a safe and happy year!
Looking forward to seeing you all again in the spring for strawberries.
Don't forget... OUR WINERY REMAINS OPEN UNTIL CHRISTMAS!!! Stop by our tasting bar and try something new. Our hours are:
Wednesday thru Friday 12-5 Saturday & Sunday 11-5
Watch for our Hopped Amber Cider.....that one caught us off guard. Apparently it's good stuff! It will return in the spring.
The Winery retail hours: - Closed Mondays and Tuesdays. - Open Wednesday, Thursday and Friday from 12pm -5pm. - Open Saturdays and Sundays 11-5 pm.
Check us out on Facebook for updates and info.
Virtual Tour of Winery Fruit Picking Hotline (905) 640-5357
Click here for contact information


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Atlantic Tele-Network, Inc. Amends Credit Facility
Atlantic Tele-Network, Inc. (NASDAQ: ATNI), announced today that it has amended and restated its existing $375 million senior secured credit facility, which consists of a $125 million and a $150 million term loan and a $100 million revolving credit facility. The amendments to the credit facility extended the final maturities of the $125 million term loan and the revolving credit facility to June 30, 2017 and the $150 million term loan to June 30, 2019. The amendments also reduced the applicable interest rate margins on borrowings under the Company's $125 million term loan and revolver loan by 75 basis points and by 25 basis points on borrowings under its $150 term loan. CoBank, ACB acted as Administrative Agent and Lead Arranger, along with Fifth Third Bank, as Joint Lead Arranger in the transaction.
Justin D. Benincasa, Chief Financial Officer of the Company, said, "This amended credit facility reflects the Company's strong operating performance and further adds to the strength of our balance sheet by extending our debt maturities, improving pricing and enhancing our financial flexibility."
The Company expects to use the proceeds from the credit facility for working capital expenses, capital expenditures, and other corporate purposes. The Company currently has approximately $10.6 million in borrowings under its revolving credit facility.
About Atlantic Tele-Network
Atlantic Tele-Network, Inc. (NASDAQ:ATNI), headquartered in Beverly, Massachusetts, provides telecommunications services to rural, niche and other under-served markets and geographies in the United States, Bermuda and the Caribbean. Through our operating subsidiaries, we provide both wireless and wireline connectivity to residential and business customers, including a range of mobile wireless solutions, local exchange services and broadband internet services and we also own and operate terrestrial and submarine fiber optic transport systems. For more information, please visit www.atni.com. Cautionary Language Concerning Forward Looking Statements This press release contains forward-looking statements relating to, among other matters, our future financial performance and results of operations; the competitive environment in our key markets, demand for our services and industry trends; the outcome of regulatory matters; our continued access to the credit and capital markets; the pace of our network expansion and improvement, including our level of estimated future capital expenditures and our realization of the benefits of these investments; and management's plans and strategy for the future. These forward-looking statements are based on estimates, projections, beliefs, and assumptions and are not guarantees of future events or results. Actual future events and results could differ materially from the events and results indicated in these statements as a result of many factors, including, among others, (1) the general performance of our operations, including operating margins, wholesale revenues, and the future retention and turnover of our subscriber base; (2) our ability to maintain favorable roaming arrangements; (3) increased competition; (4) economic, political and other risks facing our foreign operations; (5) the loss of certain FCC and other licenses, USF funds or other regulatory changes affecting our businesses; (6) rapid and significant technological changes in the telecommunications industry; (7) any loss of any key members of management; (8) our reliance on a limited number of key suppliers and vendors for timely supply of equipment and services relating to our network infrastructure and retail wireless business; (9) the adequacy and expansion capabilities of our network capacity and customer service system to support our customer growth; (10) the occurrence of severe weather and natural catastrophes; (11) our continued access to capital and credit markets; and (12) our ability to realize the value that we believe exists in our businesses. These and other additional factors that may cause actual future events and results to differ materially from the events and results indicated in the forward-looking statements above are set forth more fully under Item 1A "Risk Factors" of the Company's Annual Report on Form 10-K for the year ended December 31, 2011, filed with the SEC on March 15, 2012 and the Company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2012, filed with the SEC on May 10, 2012. The Company undertakes no obligation to update these forward-looking statements to reflect actual results, changes in assumptions or changes in other factors that may affect such forward-looking statements.Check Out Our Best Services for Investors
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Pride in Cape Town: All the pictures
Fuad Peters
The Cape Town Pride festival exploded in a rainbow of colours in the Mother City on the weekend as locals and visitors came together from a wide variety of backgrounds to celebrate and support the same cause. -
Photo essay: Cape Town from all angles
This past weekend we hosted our first Instawalk of 2015. We decided to make it a bit different and sent a few Igers to different parts of the city. We love the photos that they posted! -
A hidden gem in plain sight in Cape Town
Jenny Morris
I am not one to head out for breakfast, but after finding myself at the Lifestyle Centre in Kloof Street recently, I stumbled upon a hidden gem for the first meal of the day. Popular with locals and tourists, the Wellness Warehouse serves breakfast for all types, whether they are vegans, banting followers or simply up for anything. -
Ultra in Cape Town sets the tempo
Kristan Wood
Ultra South Africa was held in Cape Town last weekend and with some of the best local talent in the electronic dance music scene playing the event, it has set the bar high for 2015.
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Instameet Bakoven: Join in, capture and share your #lovecapetown photos with us
Calling all passionate Instagramers! We're getting together this weekend for another epic instameet to show the world how much we #lovecapetown.
Who's up for a Table Mountain Photo Challenge?
Watch two social influencers', Craig Howes and Guy McDonald, battle for who can capture the best photo of Table Mountain.
Meet Cape Town's Top Instagramers
Meet Cape Town's top Instagramers, with our #lovecapetown Instagram takeover.


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CM Punk
Phillip Jack Brooks- Birthdate: 10/26/1978 (age 36)
- Height: 6'2"
- Weight: 218 Ib
He was titled in the WWE as "the longest-reigni...
We are shown a video that recapped the final segment of last Monday's Raw, with it ending with Randy Orton knocking down Stephanie McMahon.
Once again, the ring is surrounded by tables, ladders and chairs.
Eric Rowan vs. Daniel Bryan
Rowan and Bryan start things off, a clubbing blow from Rowan. Eric shoots him into the ropes but Bryan comes back with a forearm shot. Bryan comes off the ropes but eats a shoulder block from Rowan. He locks in a bear hug but Bryan fights out with right hands. Bryan shoots off the ropes but is caught and a big throw away suplex. Rowan with a splash in the corner and follows it with a near fall. Rowan puts him in the corner and chops his chest. He misses a splash in the corner then Bryan hits a drop kick off the top. Bryan is hulking up and starts with several kicks and lands the head kick. Bryan drop kicks Harper off the apron. He hits a dive to the outside on Harper then sends Rowan out of the ring. He goes for a suicide dive to the outside but Bray trips him causing the DQ.
Winner Via DQ: Bryan in 4:00.
After the match Bryan hits a flying knee to Bray and flees to the back.
-Commercial Break-
Before the match, Zeb Colter does a promo. He says that a Santa clause asking for money and he was a Mexican descent. We the People!
Jack Swagger and Antonio Cesaro vs. Cody Rhodes and Goldust
Cesaro and Goldust start things off, Goldust with an arm drag and tags in Cody. A elbow off the top to the arm. Cesaro with a major kick to the shoulder and then tags in Swagger. They keep the pace going with quick tags in and out. Swagger goes for Swagger bomb but Cody moves and tags in Goldust, who clears the ring. Goldust with an uppercut followed by a powerbomb but a blind tag to Cesaro. Antonio comes in and throws him out of the ring.
-Commercial Break-
Were back with Swagger having him in a face lock but Goldust with a kick and he gets out of it. Swagger drags him into the corner where they keep control until Goldust hits a big elbow when he spring boards off the middle rope. Cody gets the hot tag and clears house. Couple of clotheslines then a quick roll up out of the corner for near fall. Cody his "Alabama Slamma" but Cesaro grabs the rope when he covers him. Cody misses the disaster kick and Cesaro goes for the giant swing but Goldust makes the save. Goldust is sent out to the floor and Cody hits the disaster kick. Swagger comes in but he and Cesaro are thrown to the floor. Cody hits a spring board cross body onto Cesaro. Back in the ring, Cody goes to the top rope and attempts the moonsult but Cesaro pulls him down and in mid –air hits an uppercut for the win, Wow!
Winners: Real Americans In 7:08 of ring time.
A video is shown hyping the unification match at TLC. It's the same one you saw on Raw.
-Commercial Break-
Wade Barrett does his bad news segment; he says that the fans are loser because their opinion doesn't mean anything.
Big E. Langston is on commentary.
Sandow with a kick but eats a shoulder block, Henry throws him into the corner but eats a boot. Sandow with clubbing blows but Henry with a big elbow. Sandow rolls to the floor and gets himself counted out. Langston throws him into the ring where Henry hits him with a suplex. Langston gets on the apron but Sandow knocks him down. Langston runs to the back after Sandow.
Winner Via count out: Henry in maybe 1:30?
-Commercial Break-
AJ Lee and Tamina are shown making their way out to the ring.
The Bella Twins vs. AJ Lee and Tamina Snuka
Natalya is on commentary, Nikki with a elbow then a head take over. Lee comes in and they scrap a bit until Snuka gets up and throws her across the ring. Snuka throws her into the ropes and follows it up with a Samoan drop. Lee is now in and locks in a headlock but Nikki gets out of it. Lee misses a splash in the corner and Brie comes in. She clears house and comes off the top with a drop kick for a near fall after Snuka broke it up. They throw her out of the ring but Lee...


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Intraoperative radiation therapy (IORT) is an intensive radiation treatment that's administered during surgery. IORT is used to treat cancers that are difficult to remove during surgery and there is a concern that microscopic amounts of cancer may remain. IORT allows direct radiation to the target area while sparing normal surrounding tissue.
The type of IORT most commonly used at Mayo Clinic is also called intraoperative electron radiation therapy. IORT is often combined with conventional radiation therapy, which is usually administered before surgery.
IORT allows higher effective doses of radiation to be used compared to conventional radiation therapy. It's not always possible to use very high doses during conventional radiation therapy, since sensitive organs could be nearby. IORT also allows doctors to temporarily move nearby organs or shield them from radiation exposure.
Mayo Clinic in Rochester, Minn., and Mayo Clinic in Scottsdale, Ariz., are ranked among the Best Hospitals for cancer by U.S. News & World Report. Mayo Clinic in Jacksonville, Fla., is ranked high performing for cancer by U.S. News & World Report.
At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.
Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.
Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.
Why Choose Mayo Clinic
What Sets Mayo Clinic Apart
Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.
Mayo Clinic in Arizona emphasizes a collaborative approach to care. IORT treatment involves doctors in medical oncology, radiation oncology and surgery.
For appointments or more information, call the Central Appointment Office at 800-446-2279 (toll-free) 8 a.m. to 5 p.m. Mountain Standard Time, Monday through Friday or complete an online appointment request form.
Mayo Clinic in Minnesota emphasizes a collaborative approach to care. IORT treatment involves doctors in medical oncology, radiation oncology and surgery.
For appointments or more information, call the Central Appointment Office at 507-538-3270 7 a.m. to 6 p.m. Central time, Monday through Friday or complete an online appointment request form.
See information on patient services at the three Mayo Clinic locations, including transportation options and lodging.
Mayo Clinic doctors are studying new ways of using IORT to help more patients. While IORT was initially studied in people with locally advanced disease, studies are now looking at using IORT in people with early-stage cancer. IORT research is done as part of the Mayo Clinic Cancer Center.
See a list of publications by Mayo Clinic authors on IORT on PubMed, a service of the National Library of Medicine.
Original article: http://www.mayoclinic.org/tests-procedures/intraoperative-radiation-therapy/care-at-mayo-clinic/research/prc-20013360


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"Who would have guessed? Neighborhood pet shops and superstores alike have been installing refrigerators to stock the latest pet pampering craze: Raw and frozen products that bring cat and dog food ever closer to what humans eat.According to GfK's panel representing 11,000-plus pet retail outlets, growth in refrigerated and frozen food has accelerated from 15 percent in Q2 of 2013 to 21 percent a year later, with dollar sales rising from $22.5 million to $27…"
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"In any new job, the first 30 days are crucial to learning new skills and setting goals to help determine the trajectory of your future success. During my first 30 days on the job as the Pet Industry Joint Advisory Council's (PIJAC) new president and CEO, I have traveled across…"
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A deaf family plowed into a crowd of parade attendees and knocked over a woman after claiming they feared for their safety. Police quickly became involved.
Jake T. Austin has been named in a hit and run. Read on for the 5 Fast Facts on the accident as well as all the info about the ex-Disney star.
Chris Brown is reportedly tired of being famous for his mistakes, a.k.a. his reputation for beating Rihanna. The artist says his next album will be his last.
Chris Brown allegedly curses out the woman who was involved in his 'hit and run'.
After being on probation from his Rihanna abuse charges, Chris Brown gets in two car accidents, commits a 'hit and run' and faces possible jail time as outcome.
Justin Bieber is being accused of allegedly fleeing the scene after running down a paparazzo with his Ferarri while being attacked by a group of photographers.
The fugitive crashed into Raizy and Nathan Glauber, killing them and their unborn child.
Check out this red band trailer for Hit and Run. Dax Shepard and smoking hot Kristen Bell co-star in this action-comedy written and directed by Dax himself. Take that for what you will…or don't take it at all.
Former getaway driver Charlie Bronson (Dax Shepard) jeopardizes his new life in order to help his girlfriend (Kristen Bell) get to Los Angeles. The trip isn't without a few bumps in the road as the Feds and Charlie's former gang tag along for the ride.


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St. Louis leads 3-2 (as of 10/11)
Game 1: Sunday, October 7 | ||
Washington | 3 | Final |
St. Louis | 2 | |
Recap »Boxscore » |
Game 2: Monday, October 8 | ||
Washington | 4 | Final |
St. Louis | 12 | |
Recap »Boxscore » |
Game 3: Wednesday, October 10 | ||
St. Louis | 8 | Final |
Washington | 0 | |
Recap »Boxscore » |
Game 4: Thursday, October 11 | ||
St. Louis | 1 | Final |
Washington | 2 | |
Recap »Boxscore » |
Game 5: Friday, October 12 | ||
St. Louis | 9 | Final |
Washington | 7 | |
Recap »Boxscore » |
4:07 PM ET, October 11, 2012
Nationals Park, Washington, D.C.
The St. Louis Cardinals eliminated the team with the best record in baseball in a division series en route to winning the 2011 World Series.
Their 2012 postseason is starting to look similar.The defending champions can end the Washington Nationals' amazing season Thursday in Game 4 in the nation's capital.St. Louis, which qualified for the 2011 playoffs on the final day of the regular season, surprised NL East champion Philadelphia in five games last year en route to a championship in Tony La Russa's final season as manager. The Phillies led the majors with 102 wins.This year's Cardinals won the first-ever wild-card playoff game Friday in Atlanta. After dropping the opener of this series at home, they have won the last two and are again in position to advance."You just learn how to block out all that stuff and concentrate on the moment that you're in right now and we have done a good job of that," Game 4 starter Kyle Lohse said. "We look to continue doing that. (Manager) Mike Matheny has done a great job of continuing that thought process and keeping us focused on the here and now and not worry about future or what may happen."An offense that scored 765 runs in the regular season to lead all NL playoff teams has come up big for St. Louis against a Nationals pitching staff that led the league with a 3.33 ERA. The Cardinals have totaled 20 runs in their consecutive victories, winning 8-0 on Wednesday to spoil the first postseason game in Washington in 79 years."There's a buzz all over this city," Matheny said. "There's a buzz inside the stadium. We just go out and play our game and try not to let that get in the way, whether there's a lot of life or no life at all."Pete Kozma hit a three-run homer for a 4-0 lead in the second inning Wednesday and Matt Holliday finished with three hits and two RBIs. Carlos Beltran was the hitting star with two homers in Monday's 12-4 victory.The Nationals have seen Jordan Zimmermann and Edwin Jackson turn in subpar starts over the last two games and now will give St. Louis native Ross Detwiler his first career postseason start. Detwiler went 10-8 with a 3.40 ERA this year, although he dropped his final two outings by yielding 12 runs over 7 1/3 innings."Detwiler has certainly got the stuff to pitch a good game," manager Davey Johnson insisted. "He's pitched some quality games this year. So look forward to tomorrow."Detwiler's last outing Sept. 30 was his shortest start of the year as he gave up seven runs -- three earned -- with five walks over 2 1/3 innings in a 10-4 loss to the Cardinals, also allowing a homer to Beltran. It was his first career appearance against St. Louis."I try not to remember that one, but I'm just really going out there trying to throw strikes, trying to get ahead in the count," he said. "I think I had five or six walks and I think that's what really ended up hurting me."That outing was in St. Louis, and Detwiler figures to be more confident Thursday since he went 7-2 with a 2.72 ERA in 14 home starts this year.The left-hander will need some support from an offense that was blanked by Chris Carpenter and three relievers Wednesday. The only Nationals hitting consistently in this series are Ian Desmond (7 for 12) and Ryan Zimmerman (5 for 13).Emblematic of Washington's struggles at the plate is rookie center fielder Bryce Harper, who hopes to still be in the playoffs when he turns 20 next Tuesday. Harper is 1 for 15 with no walks and six strikeouts while Adam LaRoche is 1 for 11."It's going to be tough to score if you don't hit," right fielder Jayson Werth said. "But I believe in this team, I believe in these guys. We've been here all year. Over a 162-game season, we were the best team in baseball. I still feel that way."The Nationals will be up against a confident Lohse (1-0, 3.18 ERA), who exorcised some postseason demons from his past by yielding two runs over 5 2/3 innings to earn a 6-3 win over the Braves in the wild-card game Friday. Lohse had been 0-3 with a 7.13 ERA in his first four career playoff starts."You know, I came through the Atlanta game pretty successfully, and plan on being able to do the same thing from here on out," Lohse said.The veteran right-hander, though, posted a 6.94 ERA in two September starts against Washington. Harper and Zimmerman each went 3 for 6 against him in those games while LaRoche was 3 for 5 with a homer.Copyright by STATS LLC and The Associated Press
Gameday Matchup
St. Louis | Washington | |
Night | 54-50 | 68-41 |
Grass | 88-74 | 95-64 |
Current Streak | W1 | W2 |
Last 10 | 7-3 | 6-4 |
Pitching Matchup
St. Louis | Washington | ||
K. Lohse 0-0, 0.00 ERA Last Game: 10/22 at SF 2.0 IP, 5 ER Dec = Loss |
R. Detwiler 0-0, 0.00 ERA Last Game: 10/11 at WSH 6.0 IP, 0 ER Dec = ND |
Gameday Lineups
NO. | St. Louis | Washington |
1. | J. Jay, CF | J. Werth, RF |
2. | C. Beltran, RF | B. Harper, CF |
3. | M. Holliday, LF | R. Zimmerman, 3B |
4. | A. Craig, 1B | A. LaRoche, 1B |
5. | Y. Molina, C | M. Morse, LF |
6. | D. Freese, 3B | I. Desmond, SS |
7. | D. Descalso, 2B | D. Espinosa, 2B |
8. | P. Kozma, SS | K. Suzuki, C |
9. | K. Lohse, P | R. Detwiler, P |
Injury Report
St. Louis | ||
| ||
Washington | ||
| ||
View MLB injury report |


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Event Name
- OR - Select an option belowThe setting's lux, on the Four Seasons Hotel's seventh floor outdoor terrace (if a two-acre space, with a pool and waterfall, can be called a terrace). The menu's tapas, ranging from an appetizing assortment of imported olives to more filling small plates like creamy Croquetas de Marisco (featuring lobster), Endives with Cabrales blue cheese dip and fruit, fresh anchovy fillets marinated in vinaigrette, or new potatoes with wonderfully garlicky aioli. Drinks to go with the tapas include formidable cocktails and an extensive assortment of Latin American beers, as well as wine.


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Speaking In TonguesIt's true that the poet must ever strugglewith the dead weight of words, must shapethe beginnings of meaning from all the contingencies,the accidents that blur the smooth edges of spirit's form.It's true that every beginning will falterlong before the moment is discoveredclothed in simple perfection. Though I must fail,I still can glory in a wealth of harmonicsthat a greater soul might one day resolve.
ChantryListen, child, listento the love that the bird singsmellifluous, monotonous, it chantsthe changeless song of its beingthat love, that ancient syncopation,that emptiness of the overflowing heart.
UrbanThe broken paving stones provide a niche within an unforgiving world,Tenacious weeds have multiplied around these narrow opportunitiesthese stringy plants are fitted for survival against the odds, each onepitching its separate claim to life. Beneath the ruptured slabs, spindlefilaments of roots seek sustenance in gritty soil, dark and moist. in pocketsToo shallow for the ornate costumes of the pampered rose.No horticultural art is practiced here, in this harsh universeresources must be hoarded, so close to the void of the lifeless these survivorsgrow. For them the season of flowering is brief: a short lived flash of vermillion
On The PodiumThe art of conductivityas the maestro explained,is that the man with the batonserves as a lightning rod,earthing intuitions from god.
CadenzaSuppose each one of us older than the stars,suppose that we are other than the ragged beggars we seem,suppose that our engulfing slumber, our inner darkness,is constantly erupting with the vanity of dreams.Consider those uncounted aeons swallowed in the oceansof that virtuality, where we, the ever drowning mariners,must cling to the absurd shapes we call reality.Will we, unknowing captives, ever be free?Has liberty become our cage of captivity?Oh yes, we writhe, our nakedness become despair.as our frenzied touching reveals that nothing's there.
Finale 3The heavens ablaze,Massings of vapours kindledby reflected light.The distant cosmic furnacesinks from sight, consumed by night.
ArachnidDeath sunbathesin the afternoon,Its web of shinyfilaments spread wideto entrap the unwaryblunderer.Suspended in its tranceof desire, it's fixedin motionless anticipation.It awaits the momentwhen a careless hopewill enter into oblivion.
HypnopompicA key too rustedto turn, a door once solid,now rotting away.As sentience stirs again,the dream's images decay.
ColloquyWhere, I asked, does the sun set?Have never heard? It's swallowed by the Western Sea.But how then can the sun rise?Child, your dazzled eyes are too easily misled,How can a hero rise again after he's dead?Yet I see what I have seen. Are so many heroes then,that they're extinguished every day?You have seen what you have seen,we faithless creatures can only watch and pray.
Wasted YouthHe was a lost man, trapped in a webof expectation spun by family and priests.His youthful energy sapped, he marinated in his misery.His heavy shirt of denial clung to himWhat if others might see the ailing mantrapped within this garment of fear?He believed their eyes looked right through him,that they could see the shadow of his shameful secrecy.
Past1In youth alluring,they remember camerasand their flattery.2A shadow, a shadelingers, an after imageIn the inner eye.
RecitativeYou're right. I have chosen the uniform of mourning,At first it seemed that I had made my choice pragmatically.I thought the dark mode would enhance my performing,nothing in my appearance would distract from my words.Then I realised that I was mourning indeed. Each poemexperience once lived avidly, now but a wordy husk.
Stranded 2The end of the linehad ever seemed likelyto leave the travellerabandoned in empty space,no hope of resolution.
AloneLost for the momentin a reverie, maybepast, maybe futureforms before his inner eye.His person, the empty sky.
SpeechlessWhat happens when some one too close to you dies?When in the shaded room, the high tide of pain abates, when the room is filled with final silence, when organic motion at last has ceased. The familiar face becomes a mask, no longer illuminated from within. You hold a hand mirror before the transfigured face. The reflection remains clear, unfilmed. The breath of life is no more. Solitude blossoms around you (like those chaste lilies that will decorate the funereal church).Neither staying or going will alter the implacable truth.you can speak onlyin regret's sad dialect,sighing your losses.
Need To KnowAcross the landscape of my dreamsI see an empty sky remote and glowing.All that I might be is shrouded,swallowed in a cloud of unknowingToo often I have tried, only to failexhausted by a passionate need to knowAnguish is the only crop for me to reap,the only crop that I could ever sow.
Decadent, MetallicAbandoned metaldreams of disintegration,blacktop forgotten.Functional no more,decay imposes its ownbrilliant display.
FatalityDoes he deny hope,fearing lest the contagionbe greater than he?How will the plague doctorsurvive, surrounded by death?
Heavenly FireThe sky, consumed bya spectral conflagration;embers glow brieflybefore the night's rising tidecompletely quenches the fire.