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Although 10 approvals does not appear an unduly low number, only four of those products contained genuinely new active ingredients (Arcalyst, Cimzia, Nplate, and Recothrom; Table 1). Arcalyst and Nplate are fusion proteins, Cimzia is an antibody Fab', and Recothrom is a recombinant thrombin (blood coagulation factor IIa).
In terms of expression systems used, the 2008 approvals also appeared to buck the general trend toward mammalian-based systems. Six of the 10 approved products are expressed in E. coli, one in S. cerevisiae, and three in Chinese hamster ovary (CHO) cell lines. However, the E. coli bias is less obvious in the context of genuinely novel active pharmaceutical ingredients approved, of which two are expressed in E. coli and two in CHO cells.
In most previous years too, some overlap in EU and US approvals was evident.1–4 Not so in 2008. Although approval numbers in the US were modest, they were even more disappointing in EU, with only two products coming on the market. Moreover, neither of the EU approvals (Extivia and Filgrastim Ratiopharm) were genuinely novel (see sidebar).
The only product with a likely potential of reaching blockbuster status is that of Cimzia.5 Although initially approved only for the treatment of Chron's disease, it was subsequently approved (May 2009) for the treatment of rheumatoid arthritis, greatly increasing its revenue scope.
Overall, therefore, 2008 was a modest year in terms of biopharmaceutical approvals. Analysts, however, are hopeful that this will represent a low point, with approvals likely to steadily increase once again in the coming years.5
Individual monographs for products are presented below. Monograph for Extavia, Novologmix 50:50, and PEGintron ribetol are not provided, given their particularly close similarity to well-established, previously approved products.
Changes in the country's political landscape may affect the pharmaceutical industry market in the future.
The author discusses the various ways in which a quality-by-design program can enhance the extractable and leachable assessment of a drug product.
The use of commercially available media to achieve high titer in early process development is discussed.
The fast growth of the global biopharmaceutical market has prompted global pharmaceutical and biotechnology companies to increase their R&D investment in biologics.
The draft guidance contains policies for drugs that are processed with additional manufacturing steps such as remixing, dilution, and repackaging.
The agency releases five draft guidance documents related to drug compounding and repackaging.
Market forces may limit the success of CMOs.
FDA announced that it would postpone a meeting that would be critical for the advancement of Celltrion's Remicade biosimilar in the US.
Drug shortages are declining, but they're still a serious concern for regulatory authorities, policy makers, and bio/pharmaceutical manufacturers.
The company voluntarily recalls product due to FDA observations of potential sterility problems.
More Webcasts


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Christian world
The first children Orthodox camp to open in Portugal
15. July 2013 - 13:08The Divine Liturgy was served on July 4 in the inter-parish camp organized by the Sunday school of the All Saints parish in Lisbon, reports the website of the parish.
Under the leadership of the camp director Inna Siryk and tutors Edward Kupinsky and Antonina Pishunova, the children of parishioners from Lisbon, Cascais and Porto are having their holidays at the present time in the country, in a remote plains district of the Alentejo province in the south Portugal.
The largest monastic library now opened for visiting at night
15. July 2013 - 13:01The largest Monastery library in the world which is situated in the Austrian Admont Abbey is inviting people to attend a series of events named "A night in the library". The organizers are offering eight meetings in July and August and the participants of the meetings will be able to familiarize themselves with the library's history and its richest collection.
Catholic priest killed in Syria
26. June 2013 - 13:20In Syrian region of Idlib, southeast of Aleppo, on Sunday armed rebels killed Catholic monk. This was confirmed by sources among Jerusalemite Franciscans. During an attack of the rebels on one Christian village a 59-old Syrian hermit was killed. The monastery itself was robbed. One other priest and a nun from the same place left the village unharmed. All other Christian also left this place.
Ankara upset at Vatican for Pope's remarks on mass killings of Armenians
12. June 2013 - 7:40Turkey has reacted angrily to the Vatican following a statement from Pope Francis describing the mass killings of Armenians during World War I as "the first genocide of the twentieth century" during a meeting with a delegation led by Nerses Bedros XIX, Patriarch of Cilicia of Armenian Catholics on June 3.
Return of church property confiscated by communists to begin in the Czech Republic
7. June 2013 - 7:20Return of property confiscated in the past by the communist authorities to churches will begin in the Czech Republic, reports Sedmitza.ru. The law on this issue was passed by the Czech Parliament, but left-wing parties have appealed to the Constitutional Court asking to cancel it, because in their opinion, it was not fair.
Orthodox Missionaries in Guatemala
28. May 2013 - 13:03Father David and Matushka Rozanne Rucker have been mission specialists for many years with the Orthodox Christian Mission Center (OCMC), which has missionaries around the world under the umbrella of the Assembly of Bishops. Guatemala has seen an explosive growth of Orthodox Christianity among thousands of indigenous Mayans, so now the Ruckers will be going there to live, to train catechists and clergy and to help establish the first Orthodox seminary.

subset: commoncrawl


text: 1Molina Center for Energy and the Environment, La Jolla, California, USA 2Massachusetts Institute of Technology, Cambridge, Massachusetts, USA *now at: Department of Chemistry and Biochemistry, University of California, San Diego, California, USA Abstract. The emission characteristics of mobile sources in the Mexico City Metropolitan Area (MCMA) have changed significantly over the past few decades in response to emission control policies, advancements in vehicle technologies and improvements in fuel quality, among others. Along with these changes, concurrent non-linear changes in photochemical levels and criteria pollutants have been observed, providing a unique opportunity to understand the effects of perturbations of mobile emission levels on the photochemistry in the region using observational and modeling approaches. The observed historical trends of ozone (O3), carbon monoxide (CO) and nitrogen oxides (NOx) suggest that ozone production in the MCMA has changed from a low to a high VOC-sensitive regime over a period of 20 years. Comparison of the historical emission trends of CO, NOx and hydrocarbons derived from mobile-source emission studies in the MCMA from 1991 to 2006 with the trends of the concentrations of CO, NOx, and the CO/NOx ratio during peak traffic hours also indicates that fuel-based fleet average emission factors have significantly decreased for CO and VOCs during this period whereas NOx emission factors do not show any strong trend, effectively reducing the ambient VOC/NOx ratio. This study presents the results of model analyses on the sensitivity of the observed ozone levels to the estimated historical changes in its precursors. The model sensitivity analyses used a well-validated base case simulation of a high pollution episode in the MCMA with the mathematical Decoupled Direct Method (DDM) and the standard Brute Force Method (BFM) in the 3-D CAMx chemical transport model. The model reproduces adequately the observed historical trends and current photochemical levels. Comparison of the BFM and the DDM sensitivity techniques indicates that the model yields ozone values that increase linearly with NOx emission reductions and decrease linearly with VOC emission reductions only up to 30% from the base case. We further performed emissions perturbations from the gasoline fleet, diesel fleet, all mobile (gasoline plus diesel) and all emission sources (anthropogenic plus biogenic). The results suggest that although large ozone reductions obtained in the past were from changes in emissions from gasoline vehicles, currently significant benefits could be achieved with additional emission control policies directed to regulation of VOC emissions from diesel and area sources that are high emitters of alkenes, aromatics and aldehydes. Citation: Zavala, M., Lei, W., Molina, M. J., and Molina, L. T.: Modeled and observed ozone sensitivity to mobile-source emissions in Mexico City, Atmos. Chem. Phys., 9, 39-55, doi:10.5194/acp-9-39-2009, 2009. |


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Course: Front Desk and Housekeeping Operations
The front desk is the nerve centre of the hotel where guest satisfaction issues are handled. It is the first impression that most guests have of the property, as well as the last impression as they check out. Students will explore the operating issues of this important area and become familiar with the terminology and day-to-day activities of the front-desk personnel. Students will also examine the housekeeping function in a hotel as it relates to the various other operating departments and impacts on overall guest satisfaction.
NOTE: Check with your institution as the start/end dates, prices/delivery method vary depending on what program/section/semester you are taking it in.
- Institution
- Humber College
- Language
- English
- Course Code
- Credits
- 3.00
- Delivery
- Online Anytime
- Semester
- Spring 2014, Fall 2014
- Level
- College


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How the Rise in Undercover Investigations is Changing the Law
A Moment of Simple Justice - A Prosecutor's Duty
Class Actions News - Deborah Renner on Dart Cherokee Basin v. Owens
SullCrom Sees Litigation Boom Despite Waning Credit Crisis
Your Deposition: What to Expect
Proposed FRCP Changes: Effect on eDiscovery, RIM & IG (CLE)
A Moment of Simple Justice - Stop Talking
The Burden of Proof -- What must plaintiffs prove to win their case?
How This Investment Firm Hopes to Revolutionize Litigation in America
Karl Rove's Efforts to "Buy" Courts Harmed America, Says Legendary Attorney
Winston & Strawn's Kessler Sees Change and Opportunity in College Athletics
Decision Time: Patton Boggs Partners Mull Merger With Squire Sanders
Polsinelli Podcasts - Jury or Bench Trial? A Business Litigation Survival Guide
Polsinelli Podcast - Business Litigation Survival Guide
A More Perfect Union: Why Punish Russia for Crimea?
FCPA Compliance and Ethics Report-Episode 45, Interview with Justice Ken Wise
End Game in the Fight Over Same Sex Marriage?
Bill on Bankruptcy: Delaware Garners Almost All Big Chapter 11s
Bill on Bankruptcy: Listening in the Dark at the NCBJ
International Patent Laws – Interview with Julian Crump, Managing Member, Mintz Levin's London, UK Office
Case Updates - California Supreme Court Accepts Review of Documentary Transfer Tax Case In our last quarterly update, we reported on a controversial opinion recently published by a California Court of Appeal. In 926...more
The California Court of Appeal recently held, in 926 North Ardmore Avenue v. County of Los Angeles, that a documentary transfer tax is triggered when a transfer of an interest in a business entity that owns real property...more
Case Updates - Court finds ownership of LLC membership interest does not constitute doing business in California On November 14, the Fresno County Superior Court determined that Swart, an Iowa-based corporation with a...more
Over a year ago, I wrote about an Iowa corporation, Swart Enterprises, Inc., which operates a 60 acre farm in Kansas. Swart has no physical presence in California. It owns no real or personal property in California. However,...more
In This Issue: - Sales Factor Sourcing of Services & Intangibles - Nonresident Limited Partners Liable for Personal Income Tax - PA Appeal Systems Changes Update - Personal Responsibility for...more
In Wirth v. Commonwealth, the Supreme Court of Pennsylvania held that Pennsylvania personal income tax applied to non-resident limited partners whose only connection with the state was the ownership of a small interest in a...more
On June 3, 2014, in a published decision, the California Court of Appeal for the Second Appellate District affirmed the Superior Court ruling in Ocean Avenue LLC v. County of Los Angeles, holding that even though 100 percent...more
In Bakorp Management Ltd. v. The Queen (2014 FCA 104), the Federal Court of Appeal upheld a decision of the Tax Court dismissing the taxpayer's appeal for failure to comply with the rules relating to objections and appeals...more
A foreigner starting business in the U.S. usually hires attorneys for visas, leases and licenses. The tax advisor comes later, when returns loom. This tendency is unfortunate because entering the U.S. starts the clock for...more
Today, the Maryland Court of Appeals issued its highly anticipated decision in Gore Enterprise Holdings, Inc. v. Comptroller of the Treasury; Future Value, Inc. v. Comptroller of the Treasury. The court held that under the...more
The IRS recently filed a motion to dismiss class action claims brought by Tea Party groups. In NorCal Tea Party Patriots, et. al. v. IRS, et. al., S.D. Ohio, Case No. 1:13-cv-00341, Tea Party groups asserted that the IRS...more
Happy 2014! The start of the New Year invites a look back on highlights from the past year. In case you missed it, here's a recap of what happened in the great Golden State during the last quarter of 2013....more
In United States v. Woods,1 the U.S. Supreme Court ruled unanimously for the government on two long-brewing disagreements over penalty jurisdiction in the partnership context and over the breadth of valuation misstatement...more
On December 3, 2013, the Supreme Court of the United States dismissed the applicability of the Blue Book, a commentary of recently passed tax laws prepared by the Joint Committee on Taxation, as little more than a law review...more
In This Issue: Taxpayer Wins and Loses in Statutory Residency Case; Guidance Issued on Reciprocal Credit for Sales or Use Tax; State Tax Department Issues Guidance on START-UP NY Program; and Insights in...more
The U.S. Court of Federal Claims recently held that third-party fraud committed on a partnership's tax return did not extend the three-year statute of limitations period for assessment of income taxes, a decision that...more
In Wendy's International, Inc. v. Brian Hamer, decided earlier this week, the Illinois Appellate Court found that Taxpayer had met its burden and proved that its subsidiary insurance company was a bona fide insurance company...more
3M Company's challenge to the validity of Treas. Reg. § 1.482-1(h)(2), if successful, could result in refunds for taxpayers that previously followed the Internal Revenue Service's regulatory guidance purporting to overrule...more
In Sentinel Hill Productions IV Corporation v. The Queen (2013 TCC 267), Justice Judith Woods of the Tax Court of Canada said no. In so doing, she shed light on the requirements for making an application for a determination...more
In This Issue: Gain on Sale of Non-New York Leaseholds Held Properly Sourced to New York Based on Business Allocation Percentage; Tribunal Reverses Dismissal and Allows Case to Proceed Before ALJ; Federal Court...more
In what is becoming a trend, the Massachusetts Appellate Tax Board (the "ATB") has issued yet another decision denying true debt treatment for an intercompany obligation. In National Grid Holdings, the ATB upheld assessments...more
Consistent with prior judicial precedent, the U.S. Court of Appeals for the Fifth Circuit recently applied a literal interpretation of the Subpart F inclusion rules based on the plain meaning of Sections 951 and 956....more
Congress enacted Section 409A of the Internal Revenue Code in 2004. Given the statute's complexity, the expense associated with compliance and its iron-fisted results, I've been amazed that there hasn't been a greater clamor...more
Nexus — whether a corporation has a sufficient connection such that it may be taxed by a state — is one of the most important issues in state tax. Various legal theories have been asserted (and are being asserted) to justify...more
Effective April 1, 2014, Pennsylvania's Board of Finance and Revenue will be reconstituted with independent voting members and other improved procedures. (HB 465) This is a change we and many other practitioners, as well as...more
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The American Presidency: Origins and Development, 1776-1998Now in a new edition, The American Presidency -- winner of the Benjamin Franklin Award for History, Politics and Philosophy -- examines both the constitutional precepts that underlie the presidency and the social, economic, political, and international conditions that continue to shape it. Authors Milkis and Nelson analyze the origins of the presidency and discuss the patterns of presidential conduct that developed during the nineteenth century. They argue that the modern presidency had its origins not just in Franklin D. Roosevelt, as is commonly believed, but also in the earlier administrations of Theodore Roosevelt and Woodrow Wilson. This new edition provides updated coverage of the Clinton presidency through the first half of his second term. The authors take account of new research on the presidency to make this outstanding history of the presidency as up to date as possible. |
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text:
The House That Never Sleeps
A house with windows broken out
Doesnt know when it became so
When people took out the furniture
And moved up and on
Maybe theyll come back, it thinks
But eventually,
It mourns its desertion
With flakes of falling plaster
When did I change?
How did I stumble into this alteration?
The lost woods
Echo with the resounding notes of a piano
Love is not love that alters
when it alteration finds.
Is this the way that Ive been duped
Did you make me blind?
Im so scared its real
And scared that its just passing through
The lies and imputations that cause
Me to love you
or you?
Why am I so happy that I think I wont get hurt
When it hurts so much to admit
I changed my mind
Or to wonder if Ill change it back
And hate myself for sticking to my original
Answer and turning back to what
Was not so sweet
Id ask you to wake me up when this all is over
But I cant get past you
And I cant sleep


text: i use a 4th gen ipad and have purchased the 2-5 episodes and the episode screen says 'get' at each episode, after purchasing them I immediately started downloading episode 2 and noticed it going very slow (not what you would expect from something you've just paid over £10 or $15 for) and so I left it to download for over an hour and came back to find it stuck at 97% for episode 1. I've tried restarting my iPad and downloading again. Nothing. And the money has been deducted from my account already. Anyone have any tips on how to sort this? Dying to play it as episode one was fantastic.


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With TATIANA M. PROWELL, MD, Breast Cancer Scientific Lead of the FDA's Division of Oncology Products 1, and LAURA J. VAN 'T VEER, PHD, Director of Applied Genomics at UCSF Helen Diller Family Comprehensive Cancer Center
SAN ANTONIO—There are certainly opportunities—some already underway—for successful registration of novel-novel biomarker-specific drug combinations and novel companion diagnostics for specific subsets of patients with breast cancer, Laura J. van't Veer, PhD, of UCSF's Helen Diller Family Comprehensive Cancer Center, said in an interview after moderating a session on the topic here at the 2014 San Antonio Breast Cancer Symposium. But, a key point [Ed: and challenge!], she said: "To make it all really work, we need more collaboration across countries—and across continents—to actually provide the regulatory path for drug approvals."
Van't Veer serves as Professor of Laboratory Medicine, Angela and Shu Kai Chan Endowed Chair in Cancer Research, Director of Applied Genomics, and Program Leader of Breast Oncology all at UCSF HDFCCC. And the panel she led also included Tatiana Prowell, MD, Breast Cancer Scientific Lead in the U.S. Food and Drug Administration's Division of Oncology Products 1 and Assistant Professor of Oncology in the Breast Cancer Program at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, as well as Jan H.M. Schellens, MD, PhD, of The Netherlands Cancer Institute, providing an international perspective on the topic, and Eric H. Rubin, MD, of Merck & Co., providing the pharmaceutical perspective.
In an interview after the session, Prowell and van't Veer summarized the key messages discussed and why collaborations—both domestic and internationally—are so important. They also commented on whether (and how) such cooperation is possible.
1. First, why are biomarker-specific drugs relevant in breast cancer—and important?
Prowell: "Despite success in certain disease subsets—for example HER2 positive breast cancer—we should not assume 'problem solved.' Clearly there are subsets of patients for whom current treatments don't work, or they don't work very long. It's very important for us not to get complacent.
"As we gain a better understanding of biomarkers and more widespread use of platforms that can test for multiple biomarkers efficiently, we're likely to see more progress for those very small subsets of patients who may constitute only one or two percent of the overall drug population. Those populations have the opportunity to benefit greatly if an appropriately targeted treatment is found.
"For example in lung cancer look at crizotinib, which for the four percent (or so) of patients who have an ALK-positive lung cancer—and likewise for the only one or two percent of lung cancer who have ROS1-rearranged lung cancer—that drug has quite a high response rate. So I think it's important for us not to get complacent in breast cancer subtypes where it seems like we've made a great deal of progress."
2. The session was about international collaborations. Why is that cooperation such a big part of getting these drugs developed?
van't Veer: "I have spent most of my career in the Netherlands, but have now moved the U.S. to San Francisco—so I sort of understand both worlds. What I've been observing over the last year and a half is that the global collaboration is taking off immensely because everybody understands that if you screen 10,000 breast cancer patients, you'll find 400 with a particular characteristic to be able to put in a trial. No one institution will be able to do that. So collaboration is the only way to move this forward, particularly in breast cancer where biomarker subtypes become very small groups—ER-positive, HER2-positive, HER2-negative, and all the subgroups under those."
P: "We really need to do this globally. Even if you had unlimited resources, it's just impractical for multiple different groups to be screening 10,000 patients simultaneously over and over. For example, you may have five clinical trials using anti-PD1 or anti-PDL1 agents at a given institution and patients are being individually screened for each trial. Reducing redundancy—the need to do so—is a key message that should come away from this session, not only from country to country, but also company to company."
3. Is that type of global cooperation feasible? Who is responsible? What are some of the next steps?
P: "What everyone would like to see accomplished, whether they are patients, clinicians, or a pharmaceutical company—we all want better drugs for patients. People may come at it from a different angle—the patient wants access to more treatment options or more effective or less toxic therapy. Clinicians want a longer menu of options they can offer to patients. Pharma is looking to capitalize on the R&D dollars that they put in and make a profit. The bottom line is that in order for any of those things to happen, you need the drug to get approved. So I think regulators are in a unique position to bring everyone to the table. And increasingly I think our FDA Office of Oncology and Hematology Products is taking a very much more proactive role than was the case certainly even five or ten years ago.
"One critical step: patients and clinicians should be aware that it is possible for patients to access investigational agents outside of a trial—both in the U.S. and abroad. There is a relatively straightforward process to do this and the FDA is looking to streamline that process even more so that we increase patient access to compassionate use programs and ensure greater levels of equity in terms of patients who are able to access those drugs in that setting.
"Another opportunity [in addition to streamlining that process of accessing compassionate use programs] would be requiring clinicians to report how those patients [in those programs] did in a public fashion. We have so much data that gets collected that never gets reported or never gets shared or doesn't get shared broadly enough—and that's just a lost opportunity. We need to make full use of the data that we have."
With NANDITA KHERA, MD, MPH, Assistant Professor of Medicine in Hematology/Oncology at Mayo Clinic
"I suspect I ought to ask all patients about financial vulnerabilities. After all, shouldn't it be part of my full review of symptoms? Maybe it is not quite in the same league as shortness of breath, fevers, new neurologic symptoms, or fatigue. Or is it?"
Nandita Khera, MD, MPH—Assistant Professor of Medicine in Hematology/Oncology at Mayo Clinic—poses the question in a recent Journal of Clinical Oncology Art of Oncology article (JCO 2014;32:3337-3338). And in the article's 11 succinct paragraphs, Khera makes the argument, it might just be.
Khera defines "financial toxicity" as "adverse economic consequences resulting from medical treatment." She says that financial toxicity—similar to medical toxicity—can lead to treatment nonadherence and lifestyle changes for patients that impact quality of life and increase morbidity and mortality.
Others have suggested solutions could involve government playing a bigger role to rein in costs (OT 11/10/14 issue). But, Khera's proposes that physicians themselves also need to play a bigger role in being aware of patients' financial vulnerabilities in order to be aware of how much "financial toxicity" is being caused by those patients' treatments.
In a phone interview, Khera elaborated on one solution—a standardized financial toxicity scoring system—and why it could be beneficial for patients and physicians.
1. Why do oncologists—and all physicians—need to be aware of the financial toxicities of treatments and how those toxicities affect the patients they treat?
"As physicians, we have to remember, especially as we continue from first-line treatment to second-line treatment to third-line treatment, there are economic consequences. Especially if patients are underinsured or their coverage is not great, they may accumulate a lot of debt and financial burden that can impact their lifestyle—or even their ability to continue their treatment. Both the patient and the physician have to remember that even in the face of a life-threatening illness, you still have to think about those things.
"We're finding otherwise, that as treatment moves forward, patients will ultimately come and say, 'I will not take this treatment because I will have to sell my house or do something very catastrophic to be able to do that.'
"In order to not get to that point, I think it is important that we start talking about it. It's the elephant in the room, but somebody needs to talk about it."
2. You suggest a "Grading Criteria" or standardized scoring system could help—how does it work?
"It's a tool that makes it easier for the oncologist to think about financial toxicity and creates a language so we feel comfortable communicating with each other. It's a system to screen patients and identify who may be at risk for catastrophic financial outcomes as a result of their cancer diagnosis.
"Grade one is lifestyle changes—such as not being able to afford routine expenses. And if patients are struggling with grade one financial toxicities, unless something is done they will likely progress to grade three or grade four where we are going to be dealing with much more severe outcomes—and potentially progression of the patients' tumors if they cannot continue treatment.
"Once you identify that the patient is having financial difficulties due to the cost of their treatments, at that point the physician can refer them to social services or other resources, such as drug assistance programs.
"The grading system helps address potential financial toxicities as early as possible."
3. What are the barriers to implementing a system like this one?
"One barrier is attitudes. As physicians we need to see the broad perspective that we do have some responsibility toward patients' financial well-beings.
"Second is the knowledge barrier. When we order treatments and tests, a lot of physicians don't know or are not sure what it would cost or what the cost would be for the patient. That can be hard because there is a lot of variability, but even if physicians were more aware of some of the top costs that burden their patients—that would be important in helping overcome that barrier."
With LLS's New President and CEO LOUIS J. DEGENNARO, PHD
Louis J. DeGennaro, PhD, earlier this week became President and Chief Executive Officer of The Leukemia and Lymphoma Society after serving in roles that spanned from academic centers to the private sector to the federal government. But he said new advances in blood cancer research make now an exciting time to be a part of advocacy on behalf of the cause: "The opportunity to defeat blood cancer has never been greater," he noted.
DeGennaro has served as interim President and CEO of LLS since February, having served on the Society's leadership team since 2005. He was named LLS Chief Mission Officer in 2009, in which role he played a key role in setting the society's cures and access agenda, as well as developing the Therapy Acceleration Program, a venture philanthropy endeavor that defined the role of non-profit organizations in supporting drug discovery and development with the biotechnology industry.
Prior to joining LLS, DeGennaro's experience included: being group leader of the Max Planck Institute in Munich, Germany; serving as Associate Professor of Neurology and Cell Biology at the University of Massachusetts Medical School; serving as Senior Director of Molecular Genetics at Wyeth Pharmaceuticals; serving as Executive Vice President for Research and Development at SynX Pharma, Inc.; serving as Research Manager at Streck, Inc.; and serving as a member of the National Center for Advancing Translational Sciences Advisory Council and the Cures Acceleration Network Review Board at the National Institutes of Health.
After his myriad experiences in health care, we asked DeGennaro what's exciting about this new role ahead.
1. After experience in the private sector, academia, and government, what makes you excited about this new role—and how do those experiences give you a unique perspective?
"My time in academia taught me what excellent science looks like; my time in big pharma and biotech taught me the challenges of product development; and my time here at LLS has taught me the value of the patient perspective. Together, these lessons will help me guide LLS to achieve its mission of finding cures and making certain that patients have access to life-saving treatments.
"Nearly 40 percent of cancer drugs newly approved by the FDA since the year 2000 were approved first for a blood cancer. With its research funding, LLS is paving the super highway to cancer cures. The application of genomic technology is leading to a growing fundamental understanding of the driver mutations in the hematological malignancies—and that, coupled with robust drug discovery efforts underway by the pharmaceutical industry, paints a hopeful future for new blood cancer treatments."
2. Which advances in the field would you say you are most excited about?
"In research, I'm most excited about recent advances in immunotherapy, especially: CAR T therapy which was pioneered for the treatment of leukemia at the University of Pennsylvania with $20 million in funding from LLS over more than 15 years: and new targeted therapies like the recent approval of kinase inhibitors for the treatment of chronic lymphocytic leukemia and other B-cell malignancies.
"From an advocacy perspective, we now have an opportunity to develop a nationwide network of patient and volunteer advocates who can bring greater visibility to access issues, including network adequacy and patient cost sharing."
3. So, what would you say are your goals being President and CEO of an advocacy agency that raises upwards of $300 million to support this cause?
"Our immediate goals are to continue to provide support for patients and identify and fund leading-edge blood cancer research in academia and in the private sector while providing our patients and volunteers with a powerful voice to advocate for better access to quality care. Our long-term goal: cure the blood cancers and put ourselves out of business!"
With RICHARD L. SCHILSKY, MD, FACP, FASCO, Chief Medical Officer of the American Society of Clinical Oncology
One of the biggest challenges to making personalized cancer care a reality is understanding the potential of targeted drugs outside of their approved indications, Richard L. Schilsky, MD, FASCO, Chief Medical Officer of the American Society of Clinical Oncology, said in a phone interview. He explained the key components of a new ASCO initiative to do just that.
"It's becoming more and more common to recommend molecular profiling — particularly for patients who have advanced cancer or patients who've exhausted all standard treatment options — to determine whether or not those results might suggest a course of therapy for the patient to try," he said. "But many of those drugs would have to be used off-label, or would only be available in a clinical trial. The problem becomes — how does the patient get access to the drug? And, even if the doctor can get access to the drug and treat the patient, the rest of the medical community has no way of understanding whether that particular approach actually worked in that patient with those characteristics or not."
The program proposed by ASCO — and now currently being developed by a steering committee — would capture data from real world clinical use of those drugs, and at the same time create incentives that would facilitate easier patient and physician access to those drugs.
"The point is to try to solve how to simplify access to the drug, and also how to learn from the experience of using the drug off-label so that ultimately we can gain more information about whether those approaches are worthwhile to pursue or not," Schilsky said.
He presented the idea at an American Cancer Society Cancer Action Network forum in April (OT 6/25/14 issue), and he said ASCO plans to launch the program early next year. (The program has not been formally named but is being referred to as the national access program.) Schilsky also outlined the program in a recent Nature Reviews Clinical Oncology Perspectives article (2014;11:432-438).
He spoke to OT about how and why this initiative would lead to better cancer care.
1. How would the program work?
"The program would make drugs available to patients who are willing to enroll in a prospective observational registry study. The patients would need to be enrolled in a protocol that would be similar to a clinical trial — having both eligibility and exclusion criteria, though fairly liberal — and would need to consent to have their outcomes collected so that data could be incorporated into a registry. And, we hope to enlist the interest and support of a number of pharmaceutical companies who would be willing to make some of their marketed, targeted anticancer drugs available at little or no cost to patients through this program — similar to the way they might make drugs available for an expanded access program
"The doctor treating the patient — if they believe that a molecular profiling test is medically appropriate — would have such a test performed (by whatever mechanism they would order such a test). And after reviewing results would determine whether or not one of the drugs that's available through this program is a good match for the molecular profile of the patient's tumor and might be a good treatment option. And we intend to include in the protocol some of the criteria that might be used to select a drug to use against a particular mutation site.
"The doctor would then submit the proposed treatment plan to an honest broker — an independent expert group who would review the clinical circumstances of the patient — review the molecular profiling test results, and review the proposed treatment plan offered by the physician to validate that it's a reasonable approach for this particular patient.
"Once validated, the drug would then be made available to the patient (at no cost to the patient), and the doctor would be obligated to capture the key patient outcomes, both toxicity and efficacy, in the registry."
2. And the benefits are…
"The basic premise is there are incentives for all the players to participate in a program like this one, which fundamentally provides a vehicle for capturing of good quality, real-world observational data that we can all learn a lot from — that we are not currently able to learn from the off-label prescribing of these drugs.
"Over time we could imagine accumulating lots of data — from hundreds or thousands of patients — on the off-label use of targeted drugs under well-defined circumstances, where we know the characteristics of the patient, the results of the molecular profiling test, the specific treatment that's been given, and the outcomes for the patient. And then we would share that information broadly with all the participants in the program, and then over time broadly with all of the medical community.
"The patients benefit by having easier access to drugs that they are predicted to benefit from based on molecular profiling test results. The doctors benefit by getting easier access to these treatments. And ultimately the drug companies and the insurance companies benefit by learning a lot about the way in which these drugs are performing in these off-label indications — that information might influence their decision to develop a formal clinical trial, test a promising new lead, or potentially change direction — stop planning for a clinical trial that they were contemplating if it turns out that the real world data does not support it."
3. What are the next steps to implement a system like this — and potential barriers?
"ASCO will organize the operational aspects of this, which we're writing a protocol for — and ASCO will ultimately keep the database for the registry. ASCO will also develop all the mechanisms for sharing the data. We're on a timeline to launch this program early next year.
"I've talked to representatives from all the stakeholder groups — doctors, insurance companies, patients, regulatory agencies — and everybody is intrigued by the concept here. Everybody sees its potential value; and essentially all the stakeholders have indicated a willingness to try to work toward making this a reality.
"I would say that the single biggest issue that's been raised is whether or not the data that would be collected in a project like this is actually of sufficient quality to be useful by all the stakeholders — that this real world observational data can actually enable a regulatory agency or a payer or even a clinical group to make decisions that they have to make — but we won't know until the data comes in."
With ELIZABETH SMITH, PHD, Professor in Social & Behavioral Sciences in the School of Nursing, University of California, San Francisco
Tobacco use by military personnel is harmful to individuals, it's harmful to the institution, and there's no reason to continue supporting or even allowing it — was the argument Elizabeth Smith, PhD, and six co-authors made in a recent Perspective article in the New England Journal of Medicine (DOI: 10.1056/NEJMp1405976).
"People in the military are trying to implement these policies. And it's really important that they get support from people involved in public health — doctors, nurses, and advocates, including people concerned about cancer," Smith explained in an interview with OT. Here's more on why she's focusing her attention on this issue now…
1. The health risks associated with tobacco are well-known — why is NOW the right time to restrict tobacco use in the military?
"It's been a good time for a long time. And the military has tried to do a lot of things over the past 20 years, but often Congress has prevented them from implementing strong tobacco control. For example, the Secretary of the Navy Ray Mabus wants to end tobacco sales on navy installations, but the House Armed Services Committee has put an amendment into the defense authorization bill that would prevent him from doing that.
"And that's where the problem has been for a long time — in Congress, where the tobacco industry has a lot of influence. So public health advocates really need to step up and support the military's effort to improve the health of the personnel.
"Right now is a good time [to enact this policy] partly because the support from the higher leadership does seem to be there — not only from the Secretary of the Navy, but also from the Secretary of Defense — and also because we're having a drawdown of our military as forces pull out of combat. Personnel are going to be reduced, so now is a good time to tighten rules and restrict membership."
2. Is there a precedent to restrict tobacco use in the military? What are the arguments AGAINST restricting its use by the military?
"Yes. Most fire departments do not allow their personnel to smoke because of the health consequences, which is a precedent for restricting tobacco use. It's never been declared a right.
"It's never been determined to be a right by any court and smokers are not a protected class. And, many of the rights of military personnel are curtailed in the name of good discipline or good health. Using tobacco is certainly not a benefit — we're talking about selling members of the military an addictive and deadly product. It's hard to see how that's really a benefit, but that argument does get made."
3. The NEJM Perspective article emphasizes that public health advocates need to support this initiative… Why? What are the implications for larger tobacco-cessation and cancer prevention efforts?
"Having a tobacco-free military sets a great example. It means that for young people who want to join the military, they're much less likely to start smoking if they know they won't be able to continue once they join. And once personnel leave the military, we won't have that pool of people at a higher risk of smoking rejoining civilian life and increasing smoking rates in general. It would be a significant victory."
Sarah DiGiulio
SARAH DIGIULIO, Associate Editor of Oncology Times, asks oncology's thought leaders for their perspectives and takes on the field's current news and controversies.
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Arizona League
Braves acquire Sanchez from Angels for 2 prospects
as the Angels' No. 2 prospect entering the 2015 season. Sanchez compiled a 2-2 record and 3.49 ERA for the Arizona League Angels in his first professional season. The 24-year-old Kubitza hit .295 with eight homers and 21 stolen bases
Braves acquire heralded teen pitcher Sanchez from Angels
he has a fastball that can reach 91 with a plus curveball in the low 70s. He made 12 appearances in 2014 in the Arizona League , going 2-2 with a 3.49 ERA in 38 2/3 innings pitched with 43 strikeouts. He was originally signed by current
Diamondbacks' Tomas has 'real power'
begins his U.S. career in the minor leagues. Puig started his climb to the Los Angeles Dodgers in the rookie Arizona League in 2012 before playing the first 40 games of the 2103 season at Double-A Chattanooga. In an earlier time, Alfonso
Hudson, D-backs still eyeing Sept. return
throwing one inning for the D-backs' affiliate in the Arizona League . It was a long time coming, 426 days since this ..... Hudson is scheduled to spend several weeks in the Arizona League , pitching once every four or five days, before a
There's no place like home for replay review
recovering from his second Tommy John surgery, gave up one run over four innings in four appearances in the rookie Arizona League before moving up. He is expected to make another appearance for Reno on Friday and is to join the D-backs soon
Collmenter dominates Padres
with a fractured fourth right metacarpal suffered May 31, and he was struck by a pitch in a rehab game in the rookie Arizona League at the onset of his first rehab stint, causing more swelling. "Balls inside, he couldn't really get to them
For Trumbo, long-awaited homer is all in a day's work
Daniel Hudson gave up a single and got three groundball outs while pitching an inning in his second rehab start in the Arizona League on Saturday. *Cliff Pennington had three hits and scored four times -- twice in a nine-run eighth inning
D-backs hold breath after Goldschmidt hit by pitch
disabled list the weekend before the All-Star break. *A.J. Pollock was hit by a pitch in the right hand in an Arizona League game Thursday, but X-rays were negative and he is expected to return to the lineup Saturday. The ball did not
Pirates erupt in final 2 innings, beat Arizona 9-4
played center field in his first rehab game in the Arizona League . Infielder Cliff Pennington, out since June 2 with ..... 421) in five rehab games with the Diamondbacks' Arizona League squad. ON DECK The Pirates can gain at least a split
Pirates storm back to defeat D-backs
played center field in his first rehab game in the Arizona League . Infielder Cliff Pennington, out since June 2 with ..... 421) in five rehab games with the Diamondbacks' Arizona League squad. ON DECK Vance Worley (4-1, 2.54 ERA


text: NYPD officers say they had stop-and-frisk quotasBy Marina Carver, CNNUpdated 12:15 PM ET, Tue March 26, 2013Story highlightsPolice testify they were ordered to intercept 5 people a monthSupervisors can be heard giving orders during recorded roll callsPlaintiffs in lawsuit say blacks, Hispanics unconstitutionally singled outCity maintains method is being used to deter crimeThe first week of a lawsuit seeking to reform New York's stop-and-frisk policy featured emotional accounts from men who say police stopped them for no reason and NYPD officers who say mandated quotas forced them to make unnecessary stops. The federal class-action lawsuit, Floyd v. City of New York, claims police routinely stop minority men without a legal reason. It was filed in 2008. Officer Adhyl Polanco, an eight-year veteran of the NYPD who works in the Bronx, testified Tuesday that he was told at a daily roll call that he had to log at least five stop-and-frisks, make one arrest and write 20 tickets each month, according to CNN affiliate NY1."They said, 'You do it or you are going to become a Pizza Hut deliveryman,'" Polanco said. "I started recording it because I could not believe what I was hearing."NYPD report: Most of those 'stopped and frisked' are minoritiesThe practice in which police stop, question and frisk people they consider suspicious has been widely criticized, but the police department says it is used to deter crime. According to the New York Civil Liberties Union, the NYPD logged its 5 millionth stop-and-frisk under Mayor Michael Bloomberg last week. Bronx Police Officer Pedro Serrano also taped discussions with supervisors during the daily roll call starting in 2010. Both officers said it was during these roll calls that their supervisors would urge them and their fellow officers to write more summonses, make stop-and-frisk stops and make arrests.In the recordings, which were played in court by the plaintiffs' lawyers, supervising officers can be heard saying they want "more 250s," referring to the form that officers fill out when they conduct a stop, question and frisk."If you don't want to be on a foot post, get a collar (an arrest)," supervisors also said in a recording played on Thursday.Lawyers for the city dismissed the talk of quotas. During cross-examination they pointed to the fact that police supervisors suggested Polanco and other officers might be slacking off on the job.In a recording Serrano made in February 2013, an inspector can be heard talking about stop-and-frisks, saying that officers need to stop "the right people at the right time in the right location."Later in the recording, Serrano and his superior have a conversation about Mott Haven, a notoriously high-crime area in the south Bronx that the inspector says has had many problems with robberies and grand larcenies. He continues to say, "The problem was what? Male blacks. And I told you that at roll call, and I have no problem telling you this: male blacks 14 to 20."City attorneys say that officers operate within the law, going where the crime is, and that crime happens to be higher in minority neighborhoods.Department Deputy Chief Michael Marino testified Friday that when he was overseeing the 75th precinct in Brooklyn, he had to set a goal of 10 summonses and one arrest per month because the officers were performing poorly. "Department managers can and must set performance goals," Marino said.While performance goals are legal, under a state law that was revised in 2010, quotas are not.Serrano, a nine-year police veteran, got choked up when asked why he came forward with the allegations of stop-and-frisk quotas in the NYPD."As a Hispanic walking in the Bronx, I've been stopped many times, and it's not a good feeling," he said. "As an officer, I said I would respect everyone to the best of my abilities. I just want to do the right thing."Serrano said he faced retaliation from his superiors for refusing to meet the quotas."I would have a day off and they'd give me forced (overtime)," he said to the court. "I would get yelled at, get low evaluations, they would deny days off."And after he complained about this alleged treatment to internal affairs, he said fellow officers plastered his locker with stickers of rats.Earlier in the week, teen witness Devin Almonor testified that when he was 13 he was illegally stopped, questioned and frisked, according to NY1."I want to be a voice to fight against the injustices of some of the NYPD," Almonor said. Nicholas Peart, 24, testified that he has been stopped multiple times, once in 2011 while walking to the store to get some milk. He said he feared for the safety of his siblings after the officers took his keys and went into his apartment building.According to plaintiffs' attorneys, the lawsuit is not about putting an end to stop-and-frisk, but examines how the police department conducts those stops and whether it stops blacks and Hispanics in violation of the Constitution.The Center for Constitutional Rights, a nonprofit civil rights law practice, is arguing on behalf of the plaintiffs. The lawsuit seeks to reform stop-and-frisk under the supervision of a court-appointed monitor. The lead plaintiff in the case is David Floyd, a medical student who was stopped twice, once in the middle of the afternoon when he was in front of his home in the Bronx, according to the suit. "We need somebody to look over the shoulder of the police department, not in an overly aggressive way, but in a limited way to make sure that this practice is being done in a constitutional fashion," said plaintiff attorney Jonathan Moore.City Council Speaker Christine Quinn said this week that council members have reached a "broad agreement" on a bill to have an office within the city's Department of Investigation that would be allowed to subpoena police officials and documents.The trial is expected to last four to six weeks and is scheduled to reconvene on Wednesday. The outcome will be decided by U.S. District Judge Shira A. Scheindlin.More from justiceWhy mass knife attacks are more common in AsiaSen. Menendez responds to looming criminal chargesFamily seeks answers after officer shoots immigrantPowered by Livefyre


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POSTED: Saturday, May 14, 2011 - 5:40pm
UPDATED: Monday, May 16, 2011 - 12:16pm
MORGANZA, La (NBC33) - — After weeks of waiting, the Army Corps of Engineers has opened the Morganza Spillway. The move keeps big cities like Baton Rouge and New Orleans above water, but inundates thousands of acres of farmland, and forces thousands who call the Atchafalaya Basin home, out.
"None of these decisions are easy." , says Colonel Ed Fleming, Commander of the Missisippi River Commission.
Saturday, the Corps only opened 1 of the 125 bays. They're expecting to open more as the crest gets closer. As more bays open, more fish camps and farmland will flood. Inundation maps show some places in South Central Louisiana could see over 20 feet of water.
The Corps says the spillway could stay open for up to 3 weeks.


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Funding a nest egg
James Jaillet
April 02, 2011
There's still time to lower your 2010 tax bill. Pick the right retirement account to get the biggest bang for your bucks.
Dollars and Sense
Kevin Rutherford
January 01, 2010
Over 90 percent of the U.S. population is not financially independent at retirement. Follow theses steps to put your self in the other 10 percent.
Hard Financial Choices
Todd Dills
September 01, 2009
Following are analyses of common financial tough decisions that owner-operators face, with enough information to guide you toward a wise decision.


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PHPUK 2011 Talk: Beyond Frameworks
Posted by Stuart Herbert on February 25th, 2011 in Conferences.
I've just finished giving my talk at this year's excellent PHP UK 2011 conference, on how to use code frameworks like Zend Framework and Symfony without them holding your code hostage. Here are my slides from the talk:
This talk is a follow up to my successful PHPUK 2009 about what it can be like to live with frameworks when you do product development. Looking back on that talk now, it's interesting to see how some of the themes from two years ago have changed as the business enjoyed two straight years of record growth.
If you were at the conference, and attended the talk, I'd love to read comments about how I did on joind.in.
4 Comments
Tweets that mention Stuart Herbert On PHP - » PHPUK 2011 Talk: Beyond Frameworks -- Topsy.com says:
February 25th, 2011 at 4:54 pm[...] This post was mentioned on Twitter by Planet PHP, Raden Andi Ramdani, Planet PHP, geekbay rss, Raden Andi Ramdani and others. Raden Andi Ramdani said: PHPUK 2011 Talk: Beyond Frameworks – Stuart Herbert: I've just finished giving my talk at this year's excellent … http://bit.ly/eRbUEw [...]
Henrik says:
February 28th, 2011 at 5:25 pmI must say that i enjoyed you talk even though there are some minor things that annoyed me :).
You said in the talk that Doctrine does not follow the PSR-0 Standard which i think/know is wrong but that you are right saying Symfony1 and eZ Component does not. Also that the PSR-0 group actually lists a autoloader on their site that can be used.
I agree with you perspective with the framework should be a thing layer for common components that can be integrated. But most of the code that becomes components always starts out as some simple Framework test or class and then gets converted, the trick is to know when to move the code out of the Frameworks "fists".
But all in all a good talk +1 !
Stuart Herbert says:
March 20th, 2011 at 5:04 pm@henrik: if you look inside Doctrine2, you'll see that it bundles a copy of Symfony's tools for console apps inside. Because the Symfony tools aren't at the top-level, but are inside Doctrine's own folder, it can't find the code just by using a normal PSR-0 autoloader (well, not withing telling the autoloader to look in two places, which then would cause clashes with any upstream Symfony code also installed).
gggeek says:
March 21st, 2011 at 5:51 pmAside PSR0, it looks really like an ad for the Zeta Components library (ex eZ Components). Nice to see more people agreeing on the same good principles!
BTW, it also looks a bit like an ad for SOA architectures, which are now terribly out of fashion (not a big problem), but which also generated in the past the horrible SOAP monster (that should burn in hell forever) ;-)


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Virco Stacking Chair with Trapezoidal Back and French Seam
This Virco Stack Chair features a comfortable 2'' thick seat along with a steel frame and an H-brace for extra strength.
Virco Stacking Chair with Trapezoidal Back and French Seam
Additional Documents
Weights & Dimensions
Product Type: Office | Base Type: Four legs |
Frame Finish: 1: Black | Frame Finish: 2: Silver |
Seat/Back Color: Green | Frame Material: Steel |
Seat/Back Material: Fabric | Arms Included: No |
Padding Included: Yes | Country of Manufacture: United States |
About the Manufacturer
Producing high-quality furniture for Virco's diverse family of customers is a 53-year tradition at Virco Mfg. Corporation. They've become a leading supplier of tables, chairs, and storage equipment for offices, convention centers, auditoriums, places of worship, hotels, and related settings. They're also the largest manufacturer of educational furniture in the United States.Virco employs approximately 1,400 people nationwide. Virco's 560,000 square-foot Torrance, California, headquarters features a state-of-the-art manufacturing facility, as does the Conway, Arkansas, installation, which recently added a 460,000 square-foot plant to their extensive operations. Large distribution facilities in Torrance and Conway give Virco excellent shipping access to major coastal ports.
Virco Stacking Chair with Trapezoidal Back and French Seam
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American Experience | 1964 Chapter 1 | PBS
Duration: 07:05
1964: American Experience
Broadcast Date: Jan. 15, 2014
1964 was the year the Beatles came to America, Cassius Clay became Muhammad Ali, and 3 civil rights workers were murdered in Mississippi. It was the year when Berkeley students rose up in protest, African Americans fought back against injustice in Harlem, and Barry Goldwater's conservative revolution took over the Republican Party. In myriad ways, 1964 was the year when Americans faced choices.
American Experience | 1964 Preview | PBS
Premiering January 14, 2014. The year America came apart... and was reborn. 00:31
King: Deal for release of American POW a... (#4138)
Rep. Steve King says the U.S. does not negotiate with terrorists, and the release of American POW Sgt. Bowe Bergdahl... 02:42
T. Boone Pickens says he supports any American... (#4120)
T. Boone Pickens, the wealthy oil and gas magnate and creator of the Pickens Plan on energy, says he has no vested... 01:16
American Experience | Shunned Profile: Jan | PBS
A profile of Jan, from The Amish: Shunned, premiering on PBS February 4 at 9/8c. 02:48
American Experience | Tales From the Poisoner's...
History and forensic science come together in our interactive graphic novel. 02:35
Salinger | American Masters, Trailer | PBS
The exclusive director's cut of Shane Salerno's documentary 'Salinger' premieres Tuesday, Jan. 21 at 9 p.m. on PBS... 00:35
American Masters | Marvin Hamlisch: What He... (#2605)
Full Program: Composer Marvin Hamlisch gave the world "A Chorus Line," "The Way We Were," and much more. 01:23:11
Antiques Roadshow | Appraisal: 1910 Hough's...
Appraisal: 1910 Hough's "American Woods" Set, from ROADSHOW's Special: Finders Keepers. 02:47
American Experience | 1964 Preview | PBS
Premiering January 14, 2014. The year America came apart... and was reborn. 00:31
American Experience | Coming in January 2014 | PBS
Executive Producer Mark Samels discusses new films coming in January 2014. 02:59
American Experience | The Amish: Shunned,...
Premiering February 4, 2014 at 9/8c on PBS. Former Amish choose their freedom over family. 02:00
Marvin Hamlisch, a Mensch | American Masters | PBS
Marvin Hamlisch is a mensch. What is a mensch? The term comes from the Yiddish, for "human being," but is used to... 10:05
American Experience | The Poisoner's Handbook...
In 1918, on the brink of becoming the largest metropolis in the world, New York City hired Charles Norris as its first... 00:31
American Experience | The Poisoner's Handbook...
When forensic chemistry became a formidable science. Premiering January 7, 2014 at 8/7c. 00:30
American Experience | The Gettysburg Address...
The Gettysburg Address, 150 years later - of the people, by the people, for the people. 00:00
Antiques Roadshow | Appraisal: Rudolph & Santa...
Appraisal: Rudolph & Santa Characters, ca. 1964, from ROADSHOW's Special: Survivors. 01:54
American Experience: JFK - Part Three | PBS
From PBS - This episode follows Kennedy into the White House, offering fresh assessments of the successes and... 02:00
American Experience: JFK - Part Four | PBS
From PBS - The final installment follows Kennedy through his assassination and the unfulfilled promise of his... 02:00
American Experience | JFK, Part 2, chapter 1 | PBS
Chapter 1 of Part 2 of JFK - Ask not what your country can do for you... 07:28
- Watch more video from this program
Post Date: January 7, 2014


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WILMINGTON -- A Wilmington man came close to winning the top prize on Survivor, Fiji.
Twenty-five-year-old Dre "Dreamz" Herd competed on the latest season of the CBS show. He won $100,000 after coming in second during Sunday night's finale.
Dreamz grew up in Wilmington public housing and says his experiences roughing it as a child helped him succeed on survivor.
Dreamz now works as a cheerleading instructor for the Universal Cheerleading Association.


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Pardew Needs To Get A Grip On Set-Plays!
The score ticked on yesterday against Stoke ... and I don't mean goals scored. We reached a staggering QUARTER CENTURY of corner kicks without scoring.
The 250 soon became 260, as we wasted chance after chance after chance.
Can anyone believe how a Premiership club can take so many corner kicks and not score?
I'd put Fenham Under-10's on St James' Park pitch against a Premiership team, and the laws of averages would say they would score at least ONCE from 260 corners.
The last time we scored from a corner was Demba Ba's goal against Wolves in 2011.
So WHY do we watch Newcastle play the same ball in - to the same players - with NO strategy, no system ... no idea!
Alan Pardew: "The chances were almost zero (of United scoring from a set-play).
"I said before the game we should be doing things shorter and quicker.
I thought we were slow in doing that in the first-half.
"We took some quick free-kicks. That is really how you expect to score against Stoke.
"If you're the goalie, and you have 6ft plus players protecting you, you'd come out and collect them."
Source: Newcastle United Mad
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Mayhem # 373490
About MeCorpse On Pumpkin Photography
P.O. Box 18237 Portland, OR 97213 Facebook (photography) | Facebook (books) | Tumblr TRAVEL NOTICE - LOS ANGELES – JUNE 17-28, 2013. ---> TRAVEL NOTICE | Photographer For Hire ---> June 16 to 28. Los Angeles, CA. Dear you. Fine Art, mostly B/W, Figure Portraiture. Shooting in LA this month and could use some extra work if you're looking to solicit a photographer to drink/create with. For continually updated work visit my TUMBLR PUMPKIN If interested, please inquire within for rates and things. Yours, JARET. --> (Facebook | Tumblr | YouTube | Twitter | Instagram) DEC. 2012 TOUR. On tour this holiday season shooting photographs for BRONCHO (Tulsa), doing dates with JD McPherson and Social Distortion. On the road on all dates from Dec. 6-14, so hopefully I'll get to see some of you. Night-night... 12/6 Los Angeles, CA @ Troubadour w/ JD McPherson 12/7 Santa Ana, CA @ Constellation Room w/ JD McPherson 12/8 Santa Barbara, CA @ SoHo w/ JD McPherson 12/9 Felton, CA @ Don Quixote's w/ JD McPherson 12/10 Fresno, CA @ Fulton 55 12/11 Anaheim, CA @ House Of Blues w/ Social Distortion 12/13 Los Angeles, CA @ Origami Records 12/14 Los Angeles, CA @ House Of Blues w/ Social Distortion OCTOBER 2012: Two weeks in another town(s). On tour this September with Broncho (Tulsa). Both of my books will be available at the merchandise table at all shows. See you later, alligator. Sept. 14 - Portland, OR @ Bunk Bar Sept. 16 - Seattle, WA @ Sunset Tavern Sept. 18 - San Francisco, CA @ Bottom of the Hill Sept. 19 - Santa Cruz, CA @ Crepe Place Sept. 20 - Santa Ana, CA @ Constellation Room Sept. 21 - Los Angeles, CA @ The Satellite Sept. 22 - San Diego, CA @ Soda Bar Sept. 24 - Tempe, AZ @ Yucca Tap Room Sept. 25 - Albuquerque, NM @ Low Spirits Sept. 26 - Drinks and dinner in Tulsa, OK. MAY 2012: NOVEMBER 2011: OCTOBER 2011: Available Now - PLEASE DON'T LEAVE ME, by Jaret Ferratusco Order From: Patient, Folded Hands | Powell's City of Books | Amazon MAY 2011: PAST SHOWS: CORPSE ON PUMPKIN is photographs and words composed by Jaret Ferratusco. I shoot in 35mm film, mostly in b/w. I'm very much into beautiful things and dislike most activities that are separated from art. I drink a lot. My shoots are typically rather technically comfortable and low-key; I do not employ the use of studios, sets or make-up artists, and prefer to shoot people during the day, with sunlight. It's a nice thing. I drink while shooting photographs. Thank you. Cheers. Can be found elsewhere at: - MM Profile 2 - MM Profile Color - Corpse On Pumpkin Photography - Tumblr - Blogspot - Etsy - Patient, Folded Hands Publishing - Goodreads - Powell's City of Books - Amazon Corpse On Pumpkin Photography P.O. Box 18237 Portland, OR 97213 Credits2012 Gallery Exhibits:
- October 2012 Corpse On Pumpkin | YouTube Channel, launch party. The Steep And Thorny Way To Heaven - Portland, OR. - May 2012. Contemporary Ghosts, 20 Portraits. The Space - Portland, OR. 2011 Gallery Exhibits: - October 2011. Black Portraits, 36 Photographs. Sequential Art Gallery - Portland, OR. - May 2011. Our Breath In The Whale, 19 Portraits. East Bank Commerce Center - Portland, OR. 2010 Gallery Exhibits: - Sept. 2010. Dead Relatives, 14 Portraits. East Bank Commerce Center - Portland, OR. - March 2010 Only Dust And Rain, 28 portraits. Galerie Salome - Portland, OR. 2009 Gallery Exhibits: - Feb. 2009 Calling Our Skeletons Home, 14 b/w art nudes. Opposable Thumb Gallery + Cafe - Portland, OR. - June 2009 At A Time When We Were, 8 b/w body portraits. Bumblekiss Cafe - Portland, OR. - 3 June 2009 Portraits I, 3 b/w art nudes in group exhibit Art Restores - Chicago, IL. - Sept. 2009 In Our Sleep and In Our Absences, 22 ethereal nudes. Portland Coffee House - Portland, OR. Friends |


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King committed to Coventry cause
Coventry City striker Marlon King says the loss of manager Aidy Boothroyd will not affect his commitment to the club.Having completed a four-match suspension, King's first game under caretaker boss Andy Thorn was the Sky Blues' 2-0 win against Watford. The former Watford striker told BBC Coventry & Warwickshire: "I'm contracted to Coventry City and I'll continue to give 110%. "All I can focus on is doing well when I pull on a Coventry shirt." King added: "He [Boothroyd] brought me here. I'.... read more
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148Apps Review Summary
Our Rating: :: NOT DEAD YET :: Read Our Full Review >>Dead Man's Draw is a fun deck-building card game that would be a lot more fun if it had multiplayer.
What's New
ŌŚÅ crash fix for "No Gold" pop-up in certain countriesApp Description
Stand on the knifeŌĆÖs edge between risk and reward. The turn of a single card can win bags of treasure or lose it all in this simple and strategic game of chance and skill.Every card you draw could be your last, but the right mix of wit and courage wins the booty.
ŌĆ£Creative card game that starts out simple and layers on the strategyŌĆØ
Gamezebo ŌĆō 9/10
ŌĆ£If you're after a polished and fun card game, this should be your first port of call.ŌĆØ
PocketGamer ŌĆō 8/10
ŌĆ£ŌĆśballer x-tremeŌĆÖ (that is a compliment)ŌĆØ
Tycho of Penny-Arcade
ŌĆ£YouŌĆÖre not just getting a nifty card game; youŌĆÖre getting a long steady feed of new ways to play.ŌĆØ
Quarter to Three ŌĆō 4/5 stars
ŌĆ£Best New GamesŌĆØ and ŌĆ£What WeŌĆÖre PlayingŌĆØ
Dead ManŌĆÖs Draw combines luck and strategy in a simple card-drawing format. Pulling the wrong card could bust your entire hand, but choosing the right target for a cannon blast or following a treasure map to the best destination can turn the tides in your favor more than any blind luck ever could.
Draw if you dare!
ŌŚÅ Easy to learn, challenging to master
ŌŚÅ Chain together card combos to rack up points
ŌŚÅ Win gold and unlock new treasures
ŌŚÅ Exploit unique powers granted by mystic jewels
ŌŚÅ Earn special rewards with high scores
ŌŚÅ Test your skills in 50+ distinct tournaments, with more to come
Follow us on Twitter: @DeadMansDraw
App Changes
January 29, 2014 New version 1.22
December 10, 2013 Price Decrease: $1.99 -> FREE!
December 10, 2013 New version 1.21
November 21, 2013 New version 1.20
November 01, 2013 Price Decrease: $1.99 -> FREE!
October 19, 2013 New version 1.19
October 02, 2013 Initial Release


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The Gilman International Scholarship Program, offers scholarships to U.S. citizen undergraduate students of limited financial means to pursue academic studies abroad. Programs must be a minimum of 4 weeks long to qualify. For more information contact your Study Abroad advisor, or you may contact Gilman directly at: 1.888.5939 ext. 25.
The application process is free. The program seeks to assist students from a diverse range and type of two-year and four-year public and private institutions from all 50 states. Any student who is currently receiving a Pell Grant is eligible for up to $5,000. Award amounts are based on the amount the student needs and where their application ranked among those selected. Panelists do not see the financial need information for an applicant. Need is considered once a student is selected for the scholarship, as all eligible applicants are receiving Pell Grants and considered to be in high financial need.
Once a student is selected for the Gilman Scholarship, the program determines the student's unmet need. This is determined by subtracting any financial aid (excluding loans) the student can apply towards the study abroad program from the program cost. The second factor in determining the amount of a student's award is where the student ranked in the list of selected applicants. An applicant's ranking, based on the application, is assigned by the selection panel.
Gilman International Scholarship Program
Institute of International Education
1800 West Loop South, Suite 250
Houston, TX 77027


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Film Review: The 25th Reich (2012)
SYNOPSIS: In 1943, five US soldiers are recruited by the OSS for a time travel mission to save the world from the tyranny of Hitler's 25th Reich. REV IEW: Director/Writer Stephen Amis is someone I just have to meet. After seeing "The 25th Reich" I just wanna be able to pick this man's brain and figure out what he was thinking while he was making this movie because it had the potential to be a … Continue reading


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User Rating:
I rarely/ never leave reviews but here I feel it's almost a duty to the local community. I went in for and eyebrow tidy and a back massage. Massage fine. Eyebrow tidy - disaster. The wax was too hot and my eyebrows blistered and scabbed so badly had to take time off work. I had complained at the time so got a refund for both treatments. When the scabs developed I went back to show them. The owners response was "I'm insured, so sue me". I walked out in disgust never to return. I don't recommend this place. |
User Rating:
I have used this salon frequently, they offer a wide range of treatments, always with a happy and positive demeanour. The staff and consultants could not be nicer and are very reassuring and professional. The prices are very competitive and the decor modern and inviting. |
User Rating:
Great place! I totally recommend everyone to go there! Friendly staff, good service, good prices. From my point of view is a total satisfaction. I was reading the bad reviews and i'm surprised. My appointment was respected, the girls were really, really friendly, my nails looks great every time.So feel free to go there! |
User Rating:
I cannot recommend this establishment highly enough! From the moment you walk through the door you are made to feel welcome, by the friendly receptionist(owner). The therapists are professional and very experienced.The atmosphere calm and relaxed during treatments, and the prices very reasonable. |
User Rating:
If I am having a treatment I don't want to hear the receptionist gassing away, I want to relax. Very unprofessional and avoidable, for the prices you would expect far more. Avoid avoid avoid!!! They need to think about their clients experience, clearly don't understand the word service. |
User Rating:
I've been a regualr client at 207 for years, love the staff, love the treatments and love the chatter and cups of tea! Looking forward to being pampered ahead of my big day! Name: Jennifer Location: Raynes Park |
User Rating:
I too have been going to this salon for along time and have always been happy and am surprised at the review. If you have had a bad treatment or some thing needs attention why dont you talk to the management I would. Name: Lauren Location: Wimbledon |
User Rating:
I wouldnt bother... This salon has gone down hill over the years.. It's over priced,we are in a recession So why keep putting prices up.. dirty floors and unprofessionally run.. U can't have a relaxing massage or facial without hearing the men in the gym or the receptionists/owners sitting at reception telling everyone whom walks in all about her love life are they on!! are they off.. Who cares I am a customer I don't need to hear it.. Rooms are shabby and not equipped...i felt for the therapists whom used to work here...but I can see why they leave... I booked my mum and I in for a facial and manicure a promotion they had on. it was a saturday afternoon 2010 a pre dinner treat for her birthday ( big mistake and waste of money) at the same time it was not relaxing only one steamer and one each of products the poor girls had no choice but to run from room to room disturbing each other swopping the products.. My girl couldn't find a head band or clean sponges with the cd constantly jumping. Nail files are old and been used on god knows how many other people before me. I had been going to this salon for years for waxing and the only one reason why I carried on going has now gone :-( if it was not for the therapist i wouldn't have gone back but now i find out even she has gone which is such a shame for me and a true loss to this salon... Would love to know where she has gone.. Give it a wide birth... Name: Kate Location: Raynes park |
User Rating:
I was shocked to read the review as I have just moved into the area and went into the salon to find out what they did. I found the staff very friendly and interested in helping me. Booked up my treatment for later that week. My next visit to the salon was just as welcoming as before fantastic facial & massage.Will definately becoming a regular. Name: Rachel Location: SW20 |
User Rating:
I went to 207 today to get a bikini wax done and was truly appalled with the quality of service, and technique. The lady who looked after me hardly even spoke to me when I arrived. Then handed me some broken paper knickers to put on. When I went over to tell her about this problem, she was babbling away with her colleague and didn't notice me (had to say excuse me 3 times). Once I got the adequate paper knickers on, the lady still spoken only a few words to me. I tried to engage in a conversation to no avail. The bikini line is truly wonky and she left some hairs which I then had to tweezer out at home. However, she also left me with quite a bit of wax around my bikini line, which I told her about and she just shrugged (not sure she said anything). And this lovely adventure cost me £13, that's £2 cheaper than Champneys! Overall, I would not recommend this place. |
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10/10 | Absolutely Superb | |
9/10 | Excellent / Highly Recommended | |
8/10 | Will go again | |
7/10 | Would go again | |
6/10 | Better than average | |
5/10 | Average | |
4/10 | Below average | |
3/10 | Poor | |
2/10 | Very poor | |
1/10 | Avoid | |


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1664 Views
2 Replies
Latest reply:
Feb 8, 2013 8:37 AM by
Austin Kinsella1 Aug 16, 2012 4:32 AM
Re: How can I put an appointment on multiple calendars at once in response to StadorEdit/Copy the event in one calendar, select the other calendar, Edit/Paste
jhbenoit Feb 8, 2013 8:37 AM
Re: How can I put an appointment on multiple calendars at once in response to StadorSo far the only way I have figured out to do this is add the appointment to home calendar and then "invite" myself by sending the invite to my work email. Not the ideal solution, as you still end up with 2 appointments. But at least when you update the home one, it will send an updated invitation to your work email to keep the two appointments in sync. This does not appear to work in reverse so if you update the appointment on your work calendar it does not go back and change the one on your home calendar.
I would be interested if anyone has a better solution, as I don't love this one.


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Police step up holiday enforcement
Local law enforcement agencies will be beefing up patrols during the holidays to get drunk drivers off the roads and prevent burglaries. (December 21, 2012, Page 2A)
East is city's new top cop
The Board of Aldermen has hired Joey East as the new chief of police for Oxford Police Department. East has almost 23 years in law enforcement and currently serves as assistant chief at OPD. (December 17, 2012, Page 1A)
Three finalists for OPD chief announced
The three top contenders for the Chief of Police at Oxford Police Department were announced this morning and are, current OPD Assistant Chief Joey East, Lafayette County Sheriff's Department Investigator Scott Mills and Olive Branch Assistant Chief Mark Kimbell. The three will be interviewed on Friday by the Oxford Board of Aldermen. (December 13, 2012, Page 2)
Police step up enforcement over Thanksgiving holiday
Local law enforcement officers will have extra patrols on Oxford's roads and in neighborhoods to make sure everyone has a safe Thanksgiving holiday. (November 21, 2012, Page 2)
City looks for new top cop
Three Oxford Board of Aldermen will join five members of the community to form a citizens' committee to screen applications for the chief of police. Chief Mike Martin is retiring at the end of January. (October 17, 2012, Page 1)
OPD responds to bomb threat
Local law enforcement officers responded to Lexington Pointe apartments this morning after receiving a call through 911 dispatch from someone claiming to have put bombs under the cars of several football players living in the apartments. Nothing was found however one man was taken into custody after acting suspicious in the parking lot and having alleged stolen items from vehicles in his possession. (September 18, 2012, Page 2)
Big game keeps policy busy
Local police made 75 arrests this weekend after the population of Oxford doubled when the Rebels played the University of Texas. One of the arrests was that of a former Ole Miss student who was tackled by officers when he ran onto the field during halftime in his boxers, at one point mooning the crowd. (September 17, 2012, Page 1A)
Aldermen OK $23 million budget
The Oxford Board of Aldermen approved the $23 million 2012-13 Fiscal Budget Tuesday during a recessed meeting. (September 12, 2012, Page 1, 14)
Nearly 70 arrested during first home game, holiday weekend
Local law enforcement were kept busy this weekend during Ole Miss's first home game and the Labor Day holiday. While there were several arrests for DUI, officials say it's drunk walkers they are going to be keeping a closer eye on. (September 4, 2012, Page 1)
City cuts parking spaces in evening
In an attempt to make the Square safer for pedestrians and allow for more taxi parking, several parking spots will be blocked off during evening hours. (August 23, 2012, Page 1, 5)


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"Haven't you read," he replied, "that at the beginning the
Creator 'made them male and female,' and said, 'For this reason a man will
leave his father and mother and be united to his wife, and the two will become
one flesh'? So they are no longer two, but one flesh. Therefore what God has
joined together, let no one separate."
"Why then," they asked, "did Moses
command that a man give his wife a certificate of divorce and send her away?"
Jesus replied,
"Moses permitted you to divorce your wives because your hearts were hard. But
it was not this way from the beginning. I tell you that anyone who divorces his
wife, except for sexual immorality, and marries another woman commits
Matthew 19:4-9 (NIV)
The legal profession is not short on
traps for the unwary. It creates pitfalls and labyrinths within the day-to-day
struggle to not only zealously advocate for one's client, but to also remain
faithful to the moral underpinnings developed by our worldviews in the face of
cultural pressure to conform. As Christian lawyers, these commitments,
compelled by love, keep us restrained from the addiction of compromise, not
because of its inherent desirability, but because of its inherent ease. We tether ourselves to the cross in an effort
to become a living-breathing sacrifice, to illuminate the path for those
walking in darkness and to help the glory of God be magnified in our lives
through the legal profession. During this process, Christians face a host of
issues that create undeniable conflicts. One issue is in the arena of divorce
litigation. The question of whether a Christian can be a divorce lawyer is full
of theological and legal implications. A believer's purpose is to master the
nuances of these dilemmas and conduct himself in a worthy manner. See Ephesians
4:1; Colossians 1:10; Philippians 1:27.
Christian Legal Society is honored to host this Lunch Series on the topic of
the Bible and Divorce. Professor Anthony
S. Mulford was gracious enough to offer his time and advice on the means of reconciling
the biblical model of marriage/divorce and the legal responsibility we have to
our clients. The tension is real! It is important that students begin to
wrestle with these dilemmas early in order to better prepare themselves for the
eventual conflicts. By doing this, we allow the truth of scripture to shape our
lives instead of allowing our lives to shape the truth of scripture.
CLS is here as a resource for Christian student-lawyers
dealing with the struggle of the legal profession. For more information please
visit our website at http://www.christianlegalsociety.org/
or if you're a Regent student at http://www.regent.edu/acad/schlaw/student_life/studentorgs/cls/home.cfm.
If you have any other questions, please feel free
to email Anton Sorkin (email@example.com).


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Self standing, no spill, polyethylene squeeze bottle dispenses one drop of liquid flux, oil or solvent through stainless steel hypodermic needle Bottle holds 2 oz. of liquid Three needle sizes included: .010", .020" and .054"
All three bottles I ordered leaked flux.
Thank you for the review. The flexible material used for flux bottles unfortunately makes them easy to cross-thread when tightening the lid. Please check to make sure that this isn't the case--if not, please be sure to contact our customer support team so we can get you a working product!
The cap begins skipping threads when reasonably tightened, so need to find the exact when it's tight but won't skip yet. After two days the nozzle and the little plastic washer where the needle is inserted both cracked and started leaking, so it's now useless. The washer initially came with a bit of plastic left over from molding, which I had to cut off for it to work properly The whole process of changing needles is messy. There is no needle cap, so have to either remove it every time after use, or improvise a cap.
as described
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Posts filtered on Category
Krupsak column item invokes memory
Tomorrow morning, columnist Marv Cermak will report: A recent item here about Mary Anne Krupsak, a former assemblywoman, state senator and lieutenant governor, got a rise out of Susan Partington. She recalled meeting Krupsak in 1969 when she was a fifth grader at Jefferson School in Rotterdam. Her class was on a field trip to […]
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Niskayuna candidate gets Independence support
NISKAYUNA – Republican Scott Stevens has the support of New York State Independence Party Chairman Frank MacKay in his campaign for a Niskayuna Town Board seat. MacKay said he will attend a barbecue fundraiser for Stevens 6 to 8 p.m. Thursday, July 26, at 21 Imperial Drive, Niskayuna. "Scott truly believes in the mission of […]
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Dem Denny gets nod from the GOP
If at first you don't succeed, then try again. With politics in Rotterdam, you just never know. Democrat Jack Denny was endorsed Monday by the Rotterdam Republicans for a Town Board Seat, after earlier being spurned by his own party. The local Democrats, instead, opted for two other candidates. "It's not about what party you're […]
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Rotterdam GOP could endorse Dem for Town Board
A lifelong Democrat, John 'Jack' Denny III, could end up being endorsed by Rotterdam Republicans for a Town Board seat. The executive board of the local GOP announced today it will recommend Denny in place of Tamara Tedisco who withdrew, citing family obligations. She is an independent and the niece of Republican Assembly Minority Leader […]
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Schenectady schools super staying
City School Superintendent Eric Ely is staying put. A finalist to lead the Fairfield City Schools in his native Ohio, Ely sent out a brief missive to employees on May 4 saying he was no longer a candidate, according to district spokeswoman Karen Corona. He took over as school's chief in Schenectady in January 2006, […]
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School board candidates night
Residents in two Schenectady County communities can find out more about their school board candidates in Niskayuna and Rotterdam during two separate candidates forum next week. In Niskayuna, the meet and greet session will take place at 7 p.m. on Tuesday inside the auditorium at Van Antwerp Middle School, 2253 Story Avenue. The five way […]
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Niskayuna announces candidates
Former longtime Niskayuna Schools Superintendent J. Briggs Mc Andrews has been tapped by local Republicans to run for town supervisor in the fall. McAndrews, a registered independent, tops the local GOP slate that includes neophyte town candidate Scott Stevens and his running mate Mark Stuart. Louis Chicatelli Jr. will be running for the vacancy left […]
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