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- 146Promote
Tote Bag
Our quality crafted Tote Bags are hand sewn in America using durable, yet lightweight, poly poplin fabric. All seams and stress points are double stitched for durability. Available in 13" x 13", 16" x 16" and 18" x 18" variations, the tote bags are washable, feature original artwork on both sides and a sturdy 1" wide cotton webbing strap for comfortably carrying over your shoulder.
Thank you Andre. Because of the S6 problems, I promoted one pink flower 6 times, lol. But yes, there are many, and I love them all Wendy! Thank you Angela and Deepti! I knew you would like the phone!
Thank you Greta, Shutterbug, Anna, TaLins, Viggart, Beverly and Patty! So happy =))) that you all like it
! Viggart, love the new profile pic!
! Viggart, love the new profile pic!
Hey! How'd I miss this? It's beautiful Catherine. And so cheerful. Just what I needed on a cold, dreary, winter day. =)
Aleksandra, you make me laugh! Robin, I am sorry your weather is not so great. We have had unusually warm weather! Crazy, but good! Glad you like him
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Event | Date & Location | |
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Southern Troubadours In The Round: Joe Ely, Ruthie Foster & Paul Thorn | Saturday, April 11, 2015 at 8:00 PM Paramount Theatre - Austin, TX | View Tickets |
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Baby Love eBook from Red Heart Yarns
Bonus: Get our newsletter & special offers for free. We will not share or sell your email address. View our Privacy Policy
Pastel Candy Dream Topiary Trees
By: Kathleen George for STYROFOAM Brand Foam
This candy-covered, colorful topiary is fun and easy to make for both adults and children. Use pastel Jordan almonds to decorate this as a handmade centerpiece for a baby shower or handmade bridal shower favors.
See this project and more in 27 Topiary Craft Projects.
- STYROFOAM Brand Products:
- Cone, 6"
- Balls, two 3"
- Terra cotta pots, two 4"
- Pastel Jordan almonds
- Powdered sugar, 1 lb.
- Wooden dowel, 1/4" x 6"
- Acrylic craft paint: aquamarine blue, light green, pink
- Table knife
- Ribbon, 1/2" x 1 yd., pastel
- Painting sponge
- Low temperature glue gun and glue sticks
- Insert and glue dowel in foam ball. Insert and glue remaining ball in one of the pots, trimming as needed to fit; top of ball should be slightly lower than rim of pot.
- Mix water, 1 teaspoon at a time, with 1 -1/2 cups powdered sugar; stir until smooth. Spread a thin layer of icing over cone and ball; let dry.
- Glue Jordan almonds on foam shapes, placing almonds as close together as possible. Let dry.
- Sponge paint pots; let dry.
- Insert and glue wooden dowel into pot with foam ball; glue almonds to top of pot, covering foam ball. Glue cone to top of remaining pot. To finish, tie bow around dowel on ball-shaped topiary and around rim of pot for cone-shaped topiary.
®™ Trademark of The Dow Chemical Company ("Dow") or an affiliated company of Dow.
For more project ideas, please see styrofoamstyle.com.
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The Indiana Pacers are one of the NBA's premier defensive squads.
BLOOMINGTON, Ind. (AP) Indiana beat the nation's No. 1 team Saturday night and is now in position to reclaim the top spot.
INDIANAPOLIS (AP) Rotnei Clarke scored 23 points, Roosevelt Jones added 18 and No. 9 Butler beat Rhode Island 75-68 on Saturday.
INDIANAPOLIS (AP) Ceola Clark III scored 17 points and Western Illinois beat IUPUI 68-59 on Saturday.
MINNEAPOLIS (AP) Pau Gasol had 22 points and 12 rebounds in his return to the starting lineup and Kobe Bryant nearly had a triple-double in leading the Los Angeles Lakers to a 111-100 victory ove


text: #2994: Mono = Nono ---------------------+------------------------------------------------------ Reporter: willimm | Owner: blfs-book@… Type: task | Status: closed Priority: high | Milestone: 6.5 Component: BOOK | Version: SVN Severity: blocker | Resolution: wontfix Keywords: | ---------------------+------------------------------------------------------ Changes (by randy@…): * status: new => closed * resolution: => wontfix Comment: We will let the readers decide for themselves what to install and what to avoid. We are not in the business of politics, which this issue essentially boils down to. If a reader wants to just blindly install Mono without even knowing what it does, who are we to say "don't do that"? -- Ticket URL: <http://wiki.linuxfromscratch.org/blfs/ticket/2994#comment:1> BLFS Trac <http://wiki.linuxfromscratch.org/blfs> Beyond Linux From Scratch


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My first post on Open Salon was a declaration of indignation, in August of last year I explained my disgust related to emerging rampant Gocomics.com editorial Censorship.
As described at that time, those policies remain intact. Site management essentially removes anything they're in disagreement with based on arbitrary political criteria, as stated in that comment:
Several of we Liberal content "Contributors" are directly effected and resulting complaints are widespread, we're essentially being "Targeted" by those policy changes.
But policies at that site are worsening.
I've lately posted links to editorial cartoons on Gocomics only to find that site management has removed my content "commentary" several months later, they're apparently tracking my Current Postings and editing past site content Because I've referenced it.
So let's think about the "Memory Hole" mindset at work here.
Let's say I currently comment and reference an editorial cartoon done in July of last year as I've recently done on THIS site (http://home.assets.gocomics.com/jeffdanziger/2011/07/26).
Referenced a few days ago on Open Salon while commenting on this post:
Contained in that recent comment on OpenSalon I mention that "searching my user ID [M Kitt] will display my comments" related to that editorial content.
But recent review of that July 2011 Gocomics page shows that my comments of that date have been Selectively Deleted several months after posting them.
This means, of course, that I've been the subject of much Greater editorial ire at that site than I had previously been aware of, that I'm now the object of Such Intense political attention that even comments written several months previously are being essentially UNWRITTEN at the behest of Gocomics site management.
Setting aside the fact that Freedom of Speech is the foremost issue here, I STILL can't believe the concentrated, intensely destructive intent that drives those actions. I find it difficult to grasp the extent of intended willful (Personal!) animosity that would motivate such actions on behalf of Gocomics Management.
As stated in my first posting on this subject:
*What's actually occurred to effect policy at that site appears to be Entirely Politically Based and won't likely be subject to review by "We the Public". Based on the number of other Gocomics.com paid members who're complaining about those new "Policies", I don't expect any "Official", publicly available explanation as to why these new Censorship tactics are being enforced.*
But my simply calling attention to rampant Censorship at that site isn't nearly enough of a response, doesn't address the SCOPE of the problem involved. Malicious "Memory Hole" tactics at that site require further action on my part.
For starters, I'm going to post my comments from that Goccomics page (http://home.assets.gocomics.com/jeffdanziger/2011/07/26) here for review, so that readers make their own judgment, will be enlightened regarding Gocomics' politically motivated censorship.
This way they'll observe for themselves what constitutes "objectionable content" under Gocomics Management policies.
Thanks in advance for your valued attention, we contributors should all be concerned about the results of Anti-Liberal Bias at Gocomics. Or anywhere else, for that matter.
Anyone browsing that site finding missing "M Kitt" references can post me a request here, I'll be happy to supply the "Memory Hole" deletions so reviled by Gocomics.
For Fundamentalist Bigots who support the "Norway" philosophy:
Do you think the "Twin Tower" site is a Christian Holy relic of some sort?
The NeoCons apparently do. That's the PRETENSE, anyway.
I understand the POLITICAL importance of that location to the GOP, they CAN'T admit that the entire religion if Islam ISN'T responsible for 9-11, otherwise the rationale for military intervention following that event (IE IRAQ) falls apart at the seams.
So why's it so important to you, Righties? What makes the concepts of A) Terrorists and B) Religion so difficult to differentiate in your' mind?
Let's try another comparison, no terrorism involved this time, just WAR promoted by POLITICAL GOALS.
Do you think, for instance, that all Christians are responsible for support of Hitler's rise to power in Nazi Germany?
If not, why would you support blaming all of Islam for 9-11?
Waiting for the End Times, much?
If I were you, I'd consider that the right wing agenda is based on POLITICAL, not RELIGIOUS goals.
You're being USED.
The right wing thinks that the rest of us should all bow down to their sacrosanct version of 9-11, that it's "Holy Ground" to the religious right Fringe.
This plays to the perverse NeoCon version of that event that "All Muslims are responsible" for 9-11.
Hence their Faux News Disinformation "Echo Chamber" has been cycling complete nonsense, pablum for the WingNuts about "Terrorist Mosques" ever since.
Al Qaida conducted the 9-11 operation, Islam is NOT Al Qaida any more than the White Supremecist Christian movement represents followers of Jesus.
Got a clue yet, Militant Evangelical Fundies? Al Qaida and White Supremecists are both Hate Groups and potential terrorists, NOT RELIGIONS.
Let me know if I need to simplify it further for you
Hey Sven
Prescott Bush associated with Nazis, historically FACTUAL. http://tinyurl.com/37ds8w
Using the broad brush you WingNuts seem to prefer I COULD say that's YOUR preference.
Again, let's consider where we've seen these tactics used, historically.
(IE Guilt by Association, McCarthyism in action).
Would that be insulting to you, Sven?
But I don't support using those tactics, what about you?
"Bullying Tactics" aren't about presentation of information, they're based on Smearing and Disinformation, like calling people you disagree with Nazis, Socialists, ETC.
Speaking of "Smearing", Joe McCarthy knew those tactics VERY well. The GOP "Fear Agenda" after 9-11 was a fine example of that behavior, blending Politics and Religous Bigotry to suit their needs, to cover for policies that the public would never have otherwise allowed. For instance, show me a Liberal who's in favor of RENDITION or PREEMPTIVE WAR.
So those same "Bullying Tactics" you mentioned were PERVASIVE during the George W. "Shrub" administration, to cover for their complete lack of coherent Government Policy. Not to mention what many of us recognize as Criminal Behavior, AKA WarCrimes.
Suppose if President Obama were to start a few pre-emptive wars and subsequent occupations, approve rendition of prisoners and related disregard of the Geneva Conventions, contract with his former Corporate buddies in KBR for no-bid War Enterprise profiteering, then he'd be right up there in the approval ratings with George W. and Cheney, right?
And what you're trying to call "Bullying" on my part amounts to me recounting Historically Factual Information, best I can tell ;-)
You're a fine representative member of the GOP ;-)
@Sven let's stick to comments about "Behavior" rather than to engage in debate about your preferred combined Religious/Political Doctrine.
So tell me, based on Behavior which "Lefty Socialists" are persuing invasion and occupation of Muslim Countries, Sven? And when "Lefties" oppose these ruinous policies
we're labeled "Saul Alinski" followers by "DittoHeads" like you, bet you and Limbaugh are in complete sync, huh?
And by opposing those ruinous GOP policies you've stated that "Liberals are engaging in Religious Bigotry", right? By speaking out about the pointless loss of Iraqi and U.S.
Citizens (Troops), according to Right Wing Doctrine we're being "Anti-Christian Bigots", right?
Right Wing Fundamentalists who've insisted on blaming "All of Islam" for an attack on 9-11 ARE engaging in Bigotry, for the OBVIOUS reasons I've given above.
"Al Qaida conducted the 9-11 operation, Islam is NOT Al Qaida any more than the White Supremecist Christian movement represents followers of Jesus."
Not really that difficult to understand, right? Yet NeoCons and their Fundamentalist supporters STILL promote that Bigotry, for their own Selfish, Opportunistic Reasons.
In persuit of the combined NeoCon, Fundamentalist Agenda. Let's call that agenda Middle East Conquest, and concurrent Political Control of the U.S. Government, thru the Smearing and Intimidation tactics we've all become familiar with.
But since you're inclined to label me a "Socialist Lefty", I'll ask you to clarify the status of the Religous Beliefs YOU Support, Sven.
Do you think Iraq/Afghanistan is an End-Time Holy War, Sven?
Perhaps that's why the death of so many innocent Muslims is just fine with you, unnecessarily inflicted on them by your POTUS of choice, George W.
But the entire planet (excluding the USA) is well aware that 3 or 4k dead on 9-11 can't justify AT LEAST hundreds of thousands of innocent Iraqi casualties or LIMITLESS
invasion and occupation, there's obviously No Parity, no moral equivalence.
Unless we listen to the NeoCons and their Fundamentalist Supporters who lust after "Final Days", "Rapture", "End Times", and associated endless Middle East War Rhetoric.
All to be gained thru shedding of Islamic Blood.
Thanks, Sven. The legacy of destructive Right Wing Doctrine continues, you've shown that the "True Believers" among you STILL persue the NeoCon Agenda ;-)
Further research confirms that Gocomics.com has removed ALL of my content from that site, so my above statement that they've "Selectively" deleted my earlier posts has been proven incorrect.
Instead, I've essentially been PURGED from that site.
Since I'm still a paid member of that site with "Membership" standing I'll look into the legality of this. By those actions that site apparently asserts that ALL content I've provided past and future tense is "Unacceptable".
Further evidence of Anti-Liberal bias arbitrarily based on MY POLITICAL VIEW.
Partisanship taken to the extreme, worse than I would have suspected. Complete site EXCLUSION of myself, a paying member, while allowing full access to unpaid "Visitors" supportive of the Reicht Wing
Thanks Gocomics. You've once again impressed me with further extremist CENSORING behavior, lowering the bar for editorial conduct, displaying complete intolerance of Liberal values.
Indicative of Reicht Wing "supporters" of INTOLERANCE operating true to form.


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Send Jocelyn a message explaining your needs and you will receive a response by email. Have you already emailed Jocelyn or another tutor? If so, you have an account! Sign in now
If you select this option, WyzAnt will ask interested tutors to contact you by email if they are able to help. A maximum of five different tutors will email you and none of your personal information, including your email address, will be released.
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Gillingham 1-1 Morecambe: Match Report
Last-gasp McDonald rescues GillsCody McDonald snatched a last-minute equaliser against Morecambe to extend promotion-chasing Gillingham's unbeaten run to 16 games with a 1-1 draw.Morecambe took a shock lead through Phil Jevons' controversial first-half penalty but despite piling on the pressure Gillingham had to wait until the dying stages for McDonald to pounce with his 24th goal of the season.Despite their early dominance, Gillingham fell behind on 20 minutes when Matt Lawrence was adjudged to have handled in the area when jostling for possession with Jevons.Lawrence was booked for his protests to referee Danny McDermid and Jevons kept his nerve to send Alan Julian the wrong way from the spot.The Gills responded by turning up the heat but found goalkeeper Barry Roche in inspired form as he kept out efforts from Barry Fuller, Kevin Maher and Adebayo Akinfenwa.After the break it was more of the same as McDonald went desperately close with an overhead kick before Danny Spiller wasted a glorious chance from ten yards out.Just when it seemed as if Gillingham's play-off hopes would take a major dent, Nutter's cross found McDonald at the back post and he headed home.
Gillingham 1-1 Morecambe: Match Report - view commentary, squad, and statictics of the game as it happened.
Sponsored links
Related Gillingham News


text: On 12/7/10 6:36 PM, Randy McMurchy wrote: > And the more I think about it, because they are SWIG bindings, what you > are building is worthless without a SWIG installation. I'll bet you've > never tried to actually use the bindings, or for that matter even run > the test suites for the bindings. Again, not trying to be a smart-a$$, > just trying to get to the bottom of this. Yeah, no worries. I have actually used them. Trac makes use of the python bindings, and the perl bindings are used for git-svn. Again, from the RPM spec file I use, here's the list of files installed for the perl bindings: %files perl %defattr(-,root,root) /usr/lib/perl5/site_perl/5.12.1/%{_arch}-linux/SVN /usr/lib/perl5/site_perl/5.12.1/%{_arch}-linux/auto/SVN /usr/%{_lib}/libsvn_swig_perl-1.so.0 /usr/%{_lib}/libsvn_swig_perl-1.so.0.0.0 So it actually builds and installs a full dynamic C library. It must be building what it needs from swig as shipped with the package. I can't recall what made me 'just try' as you say. It's been a long time. And I've not tried the ruby bindings (although I should). I assume they'd work the same way. JH


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From Wikipedia, the free encyclopedia - View original article
Daniel J. Harrington, S.J. (July 19, 1940 – February 7, 2014), was Professor of New Testament[1] and Chair of the Biblical Studies Department at Boston College School of Theology and Ministry (formerly Weston Jesuit School of Theology).
A member of the Society of Jesus, Fr. Harrington served as editor of New Testament Abstracts from 1972 until his death. He also edited the eighteen-volume Sacra Pagina series of New Testament commentaries for Liturgical Press and wrote "The Word" column for America magazine for three years.[2] He was a pastoral associate at St. Agnes in Arlington, Massachusetts, and at St. Peter's in Cambridge, Massachusetts. America magazine called him "one of the world's leading New Testament scholars".[1]
Harrington died of cancer in the New England Jesuit Infirmary in Weston, Massachusetts.[1]
Harrington wrote more than 40 books, including:
This Catholicism-related biographical article is a stub. You can help Wikipedia by expanding it. |


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Red kettles. The sound of bells ringing. Piles of warm sweaters to donate.
For many people, these items represent their knowledge of The Salvation Army. Here's a little more about us:
Interested in where you fit? Call 704.716.2769 or email us at firstname.lastname@example.com.
Mission Statement of The Salvation Army
The Salvation Army, an international movement, is an evangelical part of the universal ChristianChurch. Its message is based on the Bible. Its ministry is motivated by the love of God.
Its mission is to preach the gospel of Jesus Christ and to meet human needs in His name without discrimination.
Every day in Mecklenburg and Union counties, The Salvation Army provides hope, care, comfort, guidance, and encouragement to people in need. Whether it…


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And Restaurants |
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Hermiston Man Narrowly Escapes Death in Motor Home Fire on I-84 [PHOTOS]
They don't often catch fire, but when they do, they go up very quickly.
They don't often catch fire, but when they do, they go up very quickly.
The Devil's Punch Bowl State Natural Area on the Oregon coast was one of my favorite stops during my week-long summer vacation.
A competitor headed to a NASCAR regional touring series race in Monroe, WA saw their equipment damaged in a large truck fire.
I just got back from one of the most scenic areas in the world, The Metolius River near Camp Sherman Oregon. One of the Pacific NW hidden gems. This river is unique because it's head waters come from an underground reservoir and it one of the coldest rivers year round. Check out my photo's which were taken with my cell phone and are unedited.The color of the water is amazing!
There's a lot of work being done all over Oregon this summer on highways and side roads, including Eastern Oregon. We've got the details so you can plan ahead.
The Oregon State Patrol and Oregon Department of Justice are warning citizens about a new ticket scam involving traffic citations!
As definitive proof that no good deed goes unpunished, an unidentified Oregon man in his 50s has contracted the plague after rescuing a mouse from the jaws of a cat. Gah! Next time, just let nature take its course, pal.


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Imaging SoftwareOCR Software ABBYY IRIS Nuance Simple Software
editable and searchable files with ABBYY FineReader Pro for Mac. No more manual retyping or reformatting. Instead you can edit, search, share, archive, and copy information from documents for reuse and quotation — saving your time, effort and hassles.
FineReader Pro combines unmatched OCR quality, accurate document formatting reconstruction and unsurpassed language support with an intuitive interface.
The Most Accurate Text Recognition and Layout Retention Available for Mac OS X
Precise text recognition and layout retention are critical for maximum productivity. And FineReader Pro's accuracy is currently the highest in the industry: up to 99.8%, according to ABBYY's internal testings. Thismore...
- ABBYY Web Page - More Info/Brochure - Login for Demos - OCR Software - ABBYY
ABBYY FineReader® 12 Professional OCR accurately converts paper and image documents into editable formats including Microsoft Office and searchable PDF – enabling you to reuse their content, archive them more efficiently and retrieve more quickly. FineReader eliminates the need to retype documents and ensures that important information is readily available. It instantly provides access to the entire document of any size and supports 190 languages in any combinations.
convenient when you are sending documents to Cloud applications.
Recognize more than 130 languages (Improved)
ReadIRIS™ 14 is simply the best multi-lingual OCR software on the market. It recognizes more than 130 languages including Asian languages and Arabic (PC version only)!
New user-friendly interface (New)
The new tab-based user interface lets you access all the options in a single click. Processing your files has never been so intuitive and easy! (25 available interface languages).
- IRIS Web Page - More Info/Brochure - Login for Demos - OCR Software - IRIS
Readiris™ 14 is simply the best multi-lingual OCR software on the market. It recognizes more than 130 languages including Asian languages!
Powerful picturemore...
ABBYY FineReader 12 Corporate is the intelligent OCR solution for streamlining document conversion among workgroups in business, government and academic environments. Combining unmatched accuracy with ease of use and ability to automate document conversion, FineReader Corporate speeds up document processing. Comprehensive network capabilities and cost-effective licensing options are developed to meet the needs of your business.
Make every document searchable
Gather digital documents and convert scans and PDFs to searchable and usable text.
Pull Quotes and Extract Data
Extract and re-use relevant portions of text from virtually any document.
Readiris™ 14 is simply the best multi-lingual OCR software on the market. It recognizes more than 130 languages including Asian languages and Arabic (PC version only)!
Professional 14.
OmniPage Version Comparison Chart
Key Benefits
- Nuance Web Page - Login for Demos - OCR Software - Nuance
is a completely free application for basic OCR (Optical Character Recognition).
To download the full and unlimited version of the freeware at absolutely no cost, you must create a ScanStore User Account (if you have not done so already) and log-in to the site, then click on the Demos & Downloads link above to access the download link.
If you like the software, feel free to make a completely optional donation by adding the software to your cart.
If you want to use the Freeware without donating, DO NOT click "Add to Cart"! Instead follow the instructionsmore...
- Simple Software Web Page - More Info/Brochure - Login for Demos - OCR Software - Simple Software
This page was designed to help you find OCR Software quickly and easily. Click Here to find OCR Software.
We will perform on-site installation and training services at any location within a 3 hour drive of one of our offices without charging extra for airfare. However, our extensive online support options make on-site visits unnecessary for many applications.
From our headquarters in Knoxville, TN we are able to provide on-site service and support for East Tennessee (Knoxville, Oak Ridge, Maryville, Alcoa, Chattanooga, Nashville, Tri-Cities, Kingsport, TN), Western North Carolina (Asheville, Charlotte, Winston-Salem, Raleigh, Durham, NC), North Georgia (Atlanta, Athens, Augusta, GA), Western South Carolina (Greenville, Spartanburg, Columbia), North Alabama (Birmingham, Huntsville, AL), Eastern Kentucky (Louisville, Lexington, Georgetown, KY) Southern Ohio (Cincinnati, OH), and Southern Virginia (Bristol, Roanoke, Richmond, VA).
From our branch office in Boston we are able to provide on-site service and support for Massachusetts (Boston, Worcester, Springfield, MA), Rhode Island (Providence, Newport, RI), Connecticut (Hartford, New Haven, Bridgeport, Danbury, CT), Southern New Hampshire (Nashua, Manchester, NH), Eastern New York (New York City (NYC), Yonkers, Long Island, Albany, NY), New Jersey (Newark, Trenton, NJ) and Eastern Pennsylvania (Philadelphia, Allentown, Scranton, Wilkes-Barre, PA).
Current Category: Scanning, Document Imaging, Software, OCR Software
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TLDH has the end in sight, but no revenue
Top Level Domain Holdings made less than $12,000 in the first half of the year, but says its new gTLD business may start generating revenue in the fourth quarter.
In its interim financial results, published this morning, the company also revealed that it plans to launch its own domain name registrar and, via a partnership, web site building tools.
Revenue for the six months to June 30, which was almost all due to monetization of its second-level domains portfolio, was £7,000 ($11,295), compared to £346,000 ($558,000) a year earlier.
TLDH's loss for the period grew to £1.8 million ($2.9 million) from £1.5 million ($2.4 million).
But in a lengthy statement chairman Fred Krueger assured investors that he is "confident" that the long process of getting TLDH's applied-for gTLDs to market is drawing to a close.
Looking forward, I am confident that ICANN will broadly continue to sign contracts in line with the timelines we announced in July 2013, allowing .LONDON potentially to begin its launch and initial marketing as early as the first half of 2014. Given the recent signing of contract between .KIWI and ICANN, we may see our first revenues as a back-end registry operator as early as Q4 2013, and revenue from the sale of domain names from our first wholly-owned new gTLD by Q1 2014.
The company currently has interests in 25 uncontested gTLDs and has applied for 48 more, according to Krueger.
With more private and ICANN new gTLD auctions coming soon, TLDH has cash on hand of £7.4 million ($12 million).
Given the average selling price of a new gTLD is currently $1.3 million, there's seems to be little chance of TLDH securing its entire portfolio of applied-for strings without additional funding.
Losing private auctions could be a way to generate cash to win more than the nine auctions that its $12 million implies, however.
Krueger also revealed TLDH's revenue plans beyond its Minds + Machines registry services business.
As we enter into this final phase, we are pursuing other potential revenue-producing ventures by developing our own registrar, and, in cooperation with the website-building company Needly, providing a clean path for users to get a complete online solution – a web presence and email, as well as a domain name.
Krueger is also CEO of Needly, which makes a web content management platform.
Tucows and TLDH buddy up on three gTLD auctions
Top Level Domain Holdings and Tucows have made a complex deal on new gTLD applications for .store, .tech and .group.
The partnership will see TLDH take a majority stake in .group, which it hasn't also applied for, while Tucows will take minority interests in .tech and .store, which it in turn has not also applied for.
All three strings are heading to auction, with four applicants for .group, five for .tech, and six for .store.
How much each company owns of each registry will depend on how much they contribute to a winning auction bid.
TLDH CEO Antony Van Couvering said in a press release:
By combining our financial resources on these three domains not only are our chances of success improved in the auction round, but TLDH has the opportunity to acquire an interest in an additional top-level domain, .GROUP.
Tucows already plans to use TLDH subsidiary Minds + Machines as the registry back-end for the five new gTLDs it has applied for.
TLDH bags $10m in share sale
Top Level Domain Holdings has raised roughly $10 million by selling shares to institutional investors and directors.
The company, listed on the Alternative Investment Market in London, said today it has placed 110,375,276 new ordinary shares at £0.06 apiece.
The money will be used to help the company win some new gTLD contention set auctions and to promote the uncontested geo .london, which TLDH has been hired to manage.
The company is involved in 88 new gTLDs, some as applicant and some as back-end registry provider via its Minds + Machines subsidiary.
TLDH said it expects to start launching TLDs in the fourth quarter.
New hires at Donuts, DomainDiction and 101domain
It's been a busy week in the industry for executive switcheroos, with Donuts, DomainDiction and 101domain all announcing senior-level hires.
Today it emerged that Elaine Pruis, a long-time key member of the Minds + Machines team, has jumped to rival new gTLD applicant Donuts, where she's now director of operations.
That's quite a surprising move, coming so soon before gTLDs start getting delegated and — perhaps more importantly — contention set resolution deadlines start closing in.
DomainDiction, the gTLD-focused PR agency, has meanwhile lost one top expert and gained two others.
Pinky Brand, an alum of .mobi, Verisign and Iron Mountain, has gone solo, launching his own consulting business under the name [ PINKY ] • BRAND.
Former NetNames strategy director Stephane Van Gelder, an occasional DI guest poster, has been brought on as lobbyist and copywriter, while IP lawyer Bart Lieben has been hired for his considerable expertise in sunrise periods.
Neither man is on DomainDiction's exclusive payroll, and continue to have other projects.
Finally, 101domain yesterday announced that it's hired Joe Alagna as head of channel development. Alagna until recently worked in the registry world, as CentralNic's general manager for North America.
Fight over new sports gTLDs gets real ugly
The battle for contested new gTLDs .rugby and .basketball is turning nasty.
Roar Domains, a New Zealand marketing firm whose gTLD applications are backed by the official international bodies for both sports, is promising to pull out all the stops to kill off its competition.
The company, which is partnered with Minds + Machines on both bids, has told rival portfolio applicant Donuts that it will attack its applications for the two TLDs on at least three fronts.
Notably, Roar wants Donuts disqualified from the entire new gTLD program, and plans to lobby to have Donuts fail its background check.
The company told Donuts last month:
while we have no desire to join the chorus of voices speaking out against Donuts, it is incumbent on us to pursue the automatic disqualification of Applicant Guidebook Section 1.2.1, and every opposition and objection process available to us.
Applicant Guidebook section 1.2.1 deals with background checks.
Donuts came under more scrutiny than most on these grounds during the new gTLDs public comment period last year due to its co-founders being involved at the sharp end of domain investment over the last decade.
Demand Media and eNom, where founder Paul Stahura was a senior executive, have lost many UDRP cases over the years.
A mystery lawyer who refuses to disclose his clients started pursuing Donuts last August, saying the company is "unsuited and ineligible to participate in the new gTLD program."
Separate (pseudonymous?) public comments fingered a former Donuts director for allegedly cybersquatting the Olympics and Disney.
While Roar has not claimed responsibility for these specific previous attacks, it certainly seems to be planning something similar in future.
In addition, Roar and International Rugby Board, which supports Roar's application for .rugby, say they plan to official objections with ICANN about rival .rugby bids.
The IRB told Donuts, in a letter shortly before Christmas:
As the global representative of the sport and the only applicant vested with the trust and representation of the rugby community, we are unquestionably the rightful steward of .RUGBY.
Without the support of the global rugby community your commercialization efforts for .RUGBY will be thwarted. We are also preparing an objection to file against your application in accordance with ICANN rules to which you will be required to dedicate resources to formulate a response.
Roar and the IRB are also both lobbying members of ICANN's Governmental Advisory Committee, which has the power to file potentially decisive GAC Advice against any application.
Roar told Donuts recently:
Roar serves as the voice and arm for FIBA [the International Basketball Federation] and IRB in the New gTLD area. We are pleased to have obtained four Early Warnings on behalf of our applications, and fully expect the GAC process to be completed to GAC Advice.
The Early Warnings against the two other .rugby applicants were filed by the UK government — the only warnings it filed — while Greece warned the two non-Roar .basketball applicants.
Roar is also involved with the International Basketball Federation (FIBA) on its .basketball bid.
While commercial interests obviously play a huge role, there's a philosophical disagreement at the heart of these fights that could be encapsulated in the following question:
Should new gTLDs only be delegated to companies and organizations most closely affiliated with those strings?
In response to the UK's Early Warning, Donut has written to UK GAC representative Mark Carvell asking for face-to-face talks and making the case for a "neutral" registry provider for .rugby.
Donuts told Carvell:
We believe gTLDs should be run safely and securely, and in a manner that is fair to all law-abiding registrants, not only those predetermined as eligible. A neutral third party, such as Donuts, can be best capable of achieving this outcome.
Donuts believes a neutral operator is better able to ensure that the gTLD reflects the full diversity of opinion and content of all Internet users who are interested in the term "rugby."
As the IRB is a powerful voice in rugby, an IRB‐managed registry might not be neutral in its operations, raising questions about its ability to impartially oversee the gTLD. For example, will IRB/Roar chill free speech by censoring content adversarial to their interests? How would they treat third parties who are interested in rugby but aren't part of the IRB? What about IRB critics or potential rival leagues?
Despite these questions, no .rugby applicant has said it plans to operate a restricted registry. There are no applications for .basketball or .rugby designated as "Community" bids.
The IRB/Roar application specifically states "anyone can register a .rugby domain name."
Both .basketball and .rugby are contested by Roar (FIBA/IRB/M+M), Donuts (via subsidiaries) and portfolio applicant Domain Venture Partners (aka Famous Four Media, also via subsidiaries).
Roar is a sports marketing agency that is also involved in bids for .baseball, .soccer, .football and .futbol. The New Zealand national team football captain, Ryan Nelsen, is on its board.
Here are the letters (pdf).


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125...all day?? That would drive me batty. And 220..geez. Sorry that you are experiencing this problem Terry, especially with your last marathon coming up.
If it was me, I'd prefer to go with the top surgeon. Experience just makes one feel more confident and normally gives the better results (although some less experienced surgeons have also given some good results). But as you mentioned, she isn't a Cardiologist.
What about being put on the cancellation list? As you know, surgeries are cancelled sometimes, for many reasons. So it could get you in earlier.
Wishing you the Best results as always. Keeping you in my thoughts and prayers. Let us know how things are going for you. :)
Wow. I got a-fibrillation (I don't know if that's the same as flutter)after my big cancer surgery and respiratory failure. My biggest problem was that I had to take coumadin, a blood thinner and got bruises all over my body. I had to have a blood draw every week so the dose could be adjusted. I was also offered the ablation procedure but felt I'd been through enough medically and refused it. My cardiologist was a very seasoned doc and kept pushing it, but, of course, it was my choice. Then at one appointment, it was gone. I wore a monitor for 30 days to be sure, and they decided I could go off the coumadin and take a baby aspirin instead. It did come back for a few days last summer when I got hit by a car and was in the hosp for a ruptured spleen, but they attributed it to stress - LOL.
I wish you the best.
Terry , friend , thinking of you for the next step you have to take ; it's complex !...don't really know what else to say but HUGS !
That is a Good choice that you have made. We're all behind you Terry and rooting for you. God Bless! :)
good luck to you! I am scheduled for ablation on 10 August this year, and I hope my heart rate will be slower, now it is 120 or more.
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text:
US 6850786 B2 Abstract An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, inidicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
Claims(22) 1. An ophthalmic sensor for detecting an analyte in an cular fluid, comprising:
an ophthalmic lens; and
one or more detection reagents for said analyte in and/or on said ophthalmic lens, wherein the detection reagents comprise a receptor moiety and a fluorescent moiety wherein the receptor moiety comprises an analyte/competitor moiety binding site at which the analyte can reversibly bind, and wherein the fluorescent moiety in cooperation with the receptor moiety provides a detection of the analyte.
2. The ophthalmic sensor of
3. The ophthalmic sensor of clalm 2, wherein the analyte is selected from the group consisting of an electrolyte, a metallic element, a polypeptide hormone, a chronically administered medication, an acutely administered medication, small molecule hormone, a marker of inflammation, a marker of allergy, a lipid, a protein, marker of infection, and a metabolite.
4. The ophthalmic sensor of
5. The ophthalmic sensor of
6. The ophthalmic sensor of
7. The ophthalmic sensor of
8. The ophthalmic sensor of
9. The ophthalmic sensor of
10. An analyte sensor system, comprising
(a) an ophthalmic lens for detecting an analyte in an ocular fluid, having detection reagent for said analyte, wherein the detection reagent comprises a receptor moiety and a fluorescent moiety, wherein the receptor moiety comprises an analyte/competitor moiety binding site at which the analyte can reversibly bind, and wherein the fluorescent moiety in cooperation with the receptor moiety provides a detectable signal indicative of the analyte;
(b) a detector configured to detect the detectable signal.
11. The analyte sensor system of
12. The analyte sensor system of
13. The analyte sensor system of
14. The analyte sensor system of
15. The analyte sensor system of
16. The analyte sensor system of
17. The ophthalmic sensor of
18. The ophthalmic sensor of
19. The ophthalmic sensor of
20. A kit for detecting glucose in an ocular fluid, comprising:
a contact lens comprising a boronic acid derivative which can bind reversibly to glucose to provide a fluorescent signal; and
instructions for using the contact lens to detect glucose in the ocular fluid.
21. The kit of
22. The kit of
Description This application is a continuation of U.S. patent application Ser. No. 09/784, 471, filed Feb. 15, 2001 now U.S. Pat. No. 6,681,127 which is a continuation in part of PCT application PCT/EP 00/08285 filed Aug. 24, 2000, which claims the benefits of U.S. provisional application Ser. No. 60/150,792 filed Aug. 26, 1999 and U.S. provisional application Ser. No. 60/185,980 filed Mar. 1, 2000. An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid which is accessible to light. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body that is not as accessible, such as blood or intracellular fluid. Various noninvasive or minimally invasive methods to measure analytes, particularly glucose, have been described. For example, March, U.S. Pat. Nos. 3,958,560 and 4,014,321, discloses a glucose sensor wherein a patient's eye is automatically scanned using a source of light at one side of the cornea. A sensor located at the other side of the cornea detects the light that passes through the cornea. The level of glucose which rotates the plan of polarized light in the aqueous humor of the patient is a function of the amount of radiation detected. However, this sensor system is not necessarily specific or widely applicable to detection of analytes other than glucose, because it does not exploit the use of biological molecules which can detect glucose or other analytes in a body tissue or fluid sample. Biological molecules, as is well known, can provide very specific and sensitive detection reagents for particular analytes. Schultz, U.S. Pat. No. 4,344,438, discloses a system for monitoring low molecular weight compounds in blood plasma by optical means, which involves a chamber which contains specific receptor sites for the plasma constituent to be analyzed. This system is very invasive, however, because it must be implanted within the blood stream using a hypodermic needle. The system also inherently contains the risks of clotting around the device, obstruction, and other adverse reactions, including immune reactions, general irritation, and foreign body reactions. Embodiments of the present invention overcome these disadvantages in the prior art by employing an ophthalmic lens comprising a receptor moiety which comprises an analyte/competitor moiety binding site to detect an analyte in an ocular fluid. Concentration of a wide variety of analytes can be measured using an ophthalmic lens according to embodiments of the invention. Such analytes include, but are not limited to, electrolytes and small molecules (e.g., sodium, potassium, chloride, phenylalanine, uric acid, galactose, glucose, cysteine, homocysteine, calcium, ethanol, acetylcholine and acetylcholine analogs, ornithine, blood urea nitrogen, creatinine), metallic elements (e.g., iron, copper, magnesium), polypeptide hormones (e.g., thyroid stimulating hormone, growth hormone, insulin, luteinizing hormones, chorionogonadotrophic hormone), chronically administered medications (e.g., dilantin, phenobarbital, propranolol), acutely administered medications (e.g., cocaine, heroin, ketamine), small molecule hormones (e.g., thyroid hormones, ACTH, estrogen, cortisol, estrogen, and other metabolic steroids), markers of inflammation and/or allergy (e.g., histamine, IgE, cytokines), lipids (e.g., cholesterol), plasma proteins and enzymes (e.g., complement, coagulation factors, liver function enzymes, heart damage enzymes, ferritin), markers of infection (e.g., virus components, immunoglobulins such as IgM, IgG, etc., proteases, protease inhibitors), and/or metabolites (e.g., lactate, ketone bodies). Ophthalmic lenses according to embodiments of the invention can be used to monitor the course of therapy or the level of disease in mammals, including primates and, preferably, humans. In addition, because ophthalmic lenses according to embodiments of the invention provide a way to detect analytes noninvasively, they provide distinct advantages over more traditional forms of monitoring such levels. Ophthalmic lenses according to embodiments of the invention also are useful for diagnostic purposes, for example to test for pregnancy (to detect β-HCG), to assess blood chemistry (electrolytes, Ca2PO4, magnesium, bilirubin, alkaline phosphatase, lactate dehydrogenase, alanine aminotransferase, etc.), and to detect infection (e.g., by detecting components of viruses such as CMV, EBV, hepatitis, and HIV, or bacteria, such as Staphlococcus, Streptococcus, etc.). They also are useful for monitoring blood levels of test compounds during the course of assessing the compounds for use as potential therapeutics. Ophthalmic lenses according to embodiments of the invention can be worn chronically to provide repeated analyte measurements or can be worn for a single analyte measurement. Both qualitative and quantitative measurements can be performed. Ophthalmic Lens An ophthalmic lens according to embodiments of the invention can be a removable lens, such as a contact lens, or a permanently implanted lens, such as an intraocular lens, a subconjunctival lens, or an intracorneal lens. See U.S. Ser. Nos. 60/150,792 and 60/185,980, the patent applications the priority of which is claimed for this invention. Permanently implanted lenses are particularly well-suited for use in individuals who have compromised ocular function (e.g., cataracts) and also have chronic conditions which require analyte measurement, such as diabetics. Ophthalmic lenses can be corrective lenses or can be constructed so that they do not affect visual acuity. Contact lenses optionally can comprise a tint and are preferably disposable, which reduces the risk of infection for the user. As used herein, the term �ophthalmic lens� may also refer to a shunt or implant that may rest in the cul de sac of the eye. Receptor Moiety The ophthalmic lens comprises a receptor moiety. The receptor moiety comprises a binding site for the analyte to be detected. The binding site also binds a moiety which competes with the analyte for binding and is therefore referred to herein as an �analyte/competitor moiety binding site.� Binding of both the competitor moiety and the analyte to the analyte/competitor moiety, binding site is reversible. The nature of the molecule used as the receptor moiety depends on the particular analyte to be detected, but minimally includes that portion of the molecule which is sufficient to contain an analyte/competitor moiety binding site. For example, if glucose is the analyte to be detected, the receptor moiety preferably is concanavalin A (Mansouri & Schultz, Bio/Tech 2, 385, 1984), although other moieties, such as antibodies, boronic acid, a genetically engineered bacterial fluoriprotein, or glucose oxidase also can be used. Boronic acid derivatives may also be used as competitive moieties for glucose, as they form covalent complexes with glucose. For example, a combination of a fluorescence moiety, such as anthracene, boronic acid and tertiary amine gives a sensor for glucose. Illustrative, but none limiting boronic acid compounds are listed below:
Glucose binds with the acidic boronic moiety creating a fluorescent moiety. f phenylalanine is the analyte to be detected, the receptor moiety preferably comprises the active site of phenylalanine hydroxylase. It is well within the skill of those knowledgeable in the art to determine other analyte-receptor moiety binding pairs, such as uric acid-uricase, alcohol-alcohol dehydrogenase, copper-ceruloplasmin, galactose-galactokinase, cysteine- and/or homocysteine-cystathionine synthetase, acetylcholine-acetylcholinesterase, ornithine-diamine oxidase, and the like. Competitor Moiety For use in detecting an analyte, an ophthalmic lens according to embodiments of the invention preferably comprises a competitor moiety having a detectable label. The competitor moiety competes with the analyte for binding to the analyte/competitor moiety binding site. The detectable label can intrinsically be part of the competitor moiety. Alternatively, the detectable label can be a label which is not naturally associated with the competitor moiety but which is attached by means of a chemical linkage, such as a covalent bond. In preferred embodiments, the competitor moiety comprises a fluorescent label. Other detectable labels, such as luminescent or calorimetric labels, also can be used. Again, it is well within the skill of those in the art to select a competitor moiety which will compete with an analyte for binding to a particular analyte/competitor moiety binding site. For example, competitor moieties which can be used with the analyte-receptor moiety binding pairs disclosed above include fluorescein dextran (which competes with glucose for binding to concanavalin A), fluorescein polyglutamylurate (which competes with uric acid for binding to uricase), fluorescein nanolol (which competes with alcohol for binding to alcohol dehydrogenase), fluorescein-glutamine phenylacetate (which competes with phenylalnine for binding to phenylalanine hydroxylase), fluorescein-erythrocuprein (which competes with copper for binding to ceruloplasmin), fluorescein-2,3,6-tri-O-methyl galactose (which competes with galactose for binding to galactokinase), fluorescein-S-adenosyl polyhomocysteine (which competes with cysteine and homocysteine for binding to cystathionine synthetase), fluoropolyglutamyl prostigmine (which competes with acetylcholine for binding to acetylcholinesterase), and fluorospermine (which competes with ornithine for binding to diamine oxidase). Most preferably, the detectable label is more readily detectable when the competitor moiety is not bound to the analyte/competitor moiety binding site. Thus, fluorescent labels, such as fluorescein, indocyanine green, malachite green, and rhodamine, which are quenched when the competitor moiety is bound but are unquenched when the competitor moiety is not bound, are preferred for use in ophthalmic lenses according to embodiments of the invention. In addition, the sensitivity of the monitor can be controlled by altering the concentration of the detectable label. For example, the free resonance energy transfer function, an indicator of measurement sensitivity, can be increased by increasing the concentration of the detectable, label. Thus in the case of fluorescein dextran (which competes with glucose for binding to concanavalin A), increasing the concentration of fluorescein on the competitive moiety increases the range of fluorescence intensity. Increasing the range of fluorescence intensity increases the sensitivity of resulting measurements. The principle is illustrated in FIG. 14. Two different fluorescein dextran compounds, each with differing fluorescein concentrations, were tested in the same glucose environments and the fluorescence intensity measured. Sigma FITC-Dextran has a fluorescein concentration of 2% and M.P. Fluorescein-Dextran has a fluorescein concentration of 4%. Each solution was measured in a fluorophotometer with variable wavelength. The first peak is characteristic of fluorescein, the second of rhodamine. As can be seen from It is important to note the purity of the competitive moiety can influence the activity level of the detectable label. For example, in the case of fluorescein dextran, the relative level of monomers, dimers or tetramers can influence the sensitivity. Relatively pure levels of dimers seem to positively influence sensitivity. Providing Receptor and Competitor Moieties in an Ophthalmic Lens A variety of options are available for providing the receptor and competitor moieties in an ophthalmic lens. Construction of various types of ophthalmic lenses is well known in the art. Construction of contact lenses is taught, for example, in U.S. Pat. Nos. 5,965,631, 5,894,002, 5,849,811, 5,807,944, 5,776,381, 5,426,158, 4,099,859, 4,229,273, 4,168,112, 4,217,038, 4,409,258, 4,388,164, 4,332,922, 4,143,949, 4,311,573, 4,589,964, and 3,925,178. Construction of intraocular lens implants is taught, inter alia, in U.S. Pat. Nos. 6,051,025, 5,868,697, 5,762,836, 5,609,640, 5,071,432, 5,041,133, and 5,007,928. Subconjunctival lenses are taught, for example, in U.S. Pat. Nos. 5,476,511, 5,400,114, and 5,127,901. Intracorneal lenses are taught, inter alia, in U.S. Pat. Nos. 6,090,141, 5,984,961, 5,123,921, and 4,799,931. In one embodiment, the receptor moiety is covalently bound to the ophthalmic lens material. In another embodiment, the ophthalmic lens comprises a polymer meshwork containing pores. The pores are of a size which permit the competitor moiety to bind reversibly to the analyte/competitor moiety binding site, but which prevent the receptor moiety and the competitor moiety from diffusing out of the ophthalmic lens. Suitable polymers for this purpose are known in the art and include hydrogels, such as stable polymers of polyethylene glycol hydrogel (PEGH) (March et al., 2000), and modified polyvinylalcohol, such as nelfilcon A. In another embodiment, the ophthalmic lens comprises a receptor moiety layer, a polyelectrolyte layer, and a competitor moiety layer. The polyelectrolyte layer includes one or more polyelectrolytes, which are generally high molecular weight polymers with multiple ionic or ionizable functional groups. At least one polyelectrolyte in the polyelectrolyte layer has a charge opposite to the overall charge of the receptor moiety and competitor moiety layers. Suitable polyelectrolytes include positively charged PDDA (polydiallyldimethylammonium chloride) and negatively charged PAA (polyacrylic acid). Assembly of the layers is based upon sequential adsorption of oppositely charged polyions. The sensor and spacing polyelectrolytes are deposited as uniform thin films (1-10 nm) in 10-15 deposition cycles onto the porous polyvinyl alcohol or hydrogen matrix, resulting in only a 100-500 nm thick coating for the sensing film, which is highly biocompatible. A typical sequence for construction of an ophthalmic lens suitable for glucose detection involves a deposition cycle of ultrathin (1-10 nm) films of PDDA, PM, PDDA, concanavalin A, PDDA, PM, PDDA, fluorescein dextran, PDDA, PM, PDDA, PAA, concanavalin A, PM, fluorescein dextran, PM, etc. Technology for constructing ophthalmic lenses comprising such layers is taught, for example, in WO 99/35520. An ophthalmic lens according to embodiments of the invention can be provided in a kit, together with instructions for measuring analyte concentration as described below. The invention provides kits which are intended for individual patient use, in which the ophthalmic lens typically is a contact lens, as well as kits for medical practitioners, which can comprise any of the ophthalmic lenses or their equivalents described herein. Analyte Sensor System An ophthalmic lens according to embodiments of the invention can be used in an analyte sensor system. The analyte sensor system comprises an ophthalmic lens and a detector configured to detect the detectable label. For example, if the label is a luminescent label, the detector may include a luminometer; if the label is a colorimetric label, the detector may include a colorimeter; if the label is a fluorescent label, the detector may include a fluorophotometer. Construction of such devices is well known in the art. Light with wavelengths which will excite the fluorescent label can be provided, for example, by a laser or a light source, such as a light-emitting diode. A fluorophotometer suitable for use with embodiments of the invention can be constructed using a light-emitting diode from Power Technology, Inc. (Little Rock, Ark.) (see March et al., Diabetes Technol. & Ther. 2, 27-30, 2000). The detector can be a free-standing device, a table-top device, or a hand-held device. For convenience, the detector can be a miniaturized device and may be worn or carried as a personal accessory, for example, mounted in the frame of a pair of eyeglasses, clipped to an article of clothing, such as a shirt or sweater, hung around the neck, worn around the wrist, or clipped to a belt or a key ring. Using an ophthalmic lens in an analyte sensor system, as described above, embodiments of the invention provides methods of measuring analyte concentration in an ocular fluid. This measurement can, in turn, be manipulated to provide a measurement of the analyte's concentration in a body tissue or a fluid, such as blood or intracellular fluid. The relationship between glucose concentration in the aqueous humor and the blood, for example, is well known. See S�llmann, in H If desired, the analyte sensor system also can comprise a transmitter configured to transmit a signal representing whether the detectable label is detected and/or an amount of the detectable label that is detected. A device configured to vary the concentration of the analyte in a body fluid or tissue, such as an infusion pump or other pump, may receive the signal and may vary the concentration response to the signal. The signal from the analyte sensor system may comprise a continuous or discontinuous telemetry signal generated by the detector. The pump may, in response to the signal, adjust the levels of the analyte in the body by providing the user with the appropriate amount of a regulator moiety, such as insulin. Infusion pumps are well known in the art for delivering a selected medication to a patient including humans and other animals in accordance with an administration schedule which can be preselected or, in some instances, preprogrammed. Pumps for use in this invention can be worn externally or can be directly implanted into the body of a mammal, including a human, to deliver a specific medication such as insulin to the mammal in controlled doses over an extended period of time. Such pumps are well known and are described, for example, in U.S. Pat. Nos. 5,957,890, 4,923,375, 4,573,994, and 3,731,681. Medications which should optimally be maintained at a constant level, such as phenobarbital, baclofen, theophylline, and cardiac and blood pressure medications, also can be provided by means of an infusion pump. Illustrative Embodiments Illustrative embodiments of the analyte sensor system according to embodiments of the invention are shown in Conveniently, a miniaturized version of the radiation source 2 and the radiation detector 5 can be configured to be built into a pair of eyeglasses. An exemplary embodiment of this is shown in The telemetry signal 10 may include qualitative information as to whether or not the analyte is detected by the radiation detector 5. For example, where the detected light 4 is at or exceeds a predetermined threshold, the telemetry signal 10 may represent a �detected� state (such as the existence of telemetry signal 10). Where the detected light 4 is below the threshold, the telemetry signal 10 may represent a �not detected� state (such as the absence of telemetry signal 10). Alternatively, the telemetry signal 10 may indicate a change in analyte concentration. Telemetry signal 10 also may provide a warning signal if the analyte concentration is above or below a preset range. Optionally, the telemetry signal 10 may include quantitative information as to how much light 4 is detected by the radiation detector 5. For instance, the telemetry signal 10 may be varied in amplitude and/or frequency responsive to the amount of light 4 detected, where the amplitude and/or frequency represents the amount of light 4. As another example, the telemetry signal 10 may include digital data representing the amount of detected light 4. If the telemetry signal 10 is analog, the telemetry signal 10 may be generated by the detector 5, which may include a modulator for generation of the telemetry signal 10. If the telemetry signal 10 is digital, the telemetry signal 10 may be generated by an analog-to-digital (�A/D�) converter 70. Also, the amount of the light 4 detected by the radiation detector 5 may be shown on a display 71 (which may include a display driver), such as a CRT screen or liquid crystal display (�LCD�). All patents and patent applications cited in this disclosure are expressly incorporated herein by reference. The above disclosure generally describes the present invention. A more complete understanding can be obtained by reference to the following specific examples which are provided for purposes of illustration only and are not intended to limit the scope of the invention. Construction of an Intraocular Glucose Sensor A structurally stable polymer of polyethylene glycol hydrogel (PEGH, Shearwater Polymers, Inc.) is used to construct an intraocular glucose sensor. PEGH is immobilized in an intraocular lens (Alcon Laboratories, 6 mm circumference, 1 mm thickness). Chemically immobilized pendant tetramethylrhodamine isothiocyanate concanavalin A (TRITC-ConA, Sigma) is incorporated into the PEGH as the receptor moiety and fluorescein isothiocyanate dextran (FITC-dextran, Sigma) is incorporated as the competitor moiety by polymerization under UV light, as described by Ballerstadt & Schultz, Anal. Chim. Acta 345, 203-12, 1997, and Russell & Pishko, Anal. Chem. 71, 3126-32, 1999. While the FITC-dextran is bound to the TRITC-ConA, the FITC fluorescence is quenched via a fluorescence resonance energy transfer. Increased glucose concentration frees the FITC-dextran and results in fluorescence which is proportional to glucose concentration. Implantation of an Intraocular Glucose Sensor In Vivo The intraocular lens glucose sensor described in Example 1 is implanted into the anterior chamber of the eye of a living New Zealand rabbit with a blood glucose concentration of 112 mg %. The implant is visible as a bright spot of green fluorescence (518 nm) within the eye. Careful examination with a biomicroscope slit lamp shows no sign of toxicity, rejection, or any reaction 6 months after implantation. Patent Citations
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sail-world.com -- Extreme Sailing Series - Of SpeedDreams and Tilt-ing things
Extreme Sailing Series - Of SpeedDreams and Tilt-ing things
Fri, 17 May 2013
The next two Acts of the Extreme Sailing Series are to be staged in Istanbul, Turkey (20-23 June) and Porto, Portugal (25-28 July) and now Team Tilt, the Swiss team selected for the Red Bull Youth America's Cup, has announced their participation in both events - as the global tour heads back to Europe for the summer months. Also new to the Series is SpeedDream, an ambitious project that aims to build the world's fastest monohull, and will join the NeilPryde Windsurf Racing Series as warm-up acts.
Since Team Tilt's qualification for the Youth America's Cup, the team of young sailors have embarked on a demanding training programme which includes racing on different high-performance multihull classes including the Decision 35, M2 and the Extreme 40. Just last weekend, the team competed in the first Vulcain Trophy event of the season where they came up against the Extreme 40 crews and their Swiss countrymen onboard Alinghi and Realteam for the first time.
Lucien Cujean, the teams skipper, who started sailing multihulls in 2007 alongside offshore legend Alain Gautier, himself a former Extreme 40 helm, commented:
'The forthcoming Extreme Sailing Series Acts in Istanbul and Porto are a great opportunity for us and perfect to prepare ourselves as best as possible for our ultimate objective, winning The Red Bull Youth America's Cup. The Extreme sailing Series has some of the best multihull sailors in the world and for us it will be a great opportunity to compete alongside these very talented sailors. It's also a new racing format that we will have to quickly adapt to. So, we have a huge learning curve ahead of us.'
Cujean will be joined by Jocelyn Keller as tactician, Jeremy Bachelin mainsail trimmer, Thomas Mermod headsail trimmer, with the bowman's position still to be decided between Mikis Psarosfaghis and Jonas Schagen. As well as giving Team Tilt the chance for some valuable multihull training, joining the Extreme Sailing Series will also give them the chance to size up the competition from the Kiwi Youth America's Cup contingent onboard GAC Pindar, led by William Tiller.
As part of the Series' continually developing entertainment programme, SpeedDream will add an exciting new element for the VIP's and public in Istanbul. As part of the projects quest to build the world's fastest monohull, SpeedDream have integrated some of their innovative design ideas, such as a flying keel, wave piercing bow and stepped hull, into a 27-foot prototype and Cam Lewis, one of the world's most celebrated sailors as the first holder of the coveted Jules Verne Trophy and winner of the 1988 America's Cup, will be in the driving seat demo-sailing the boat and bringing high speeds and excitement to the event in Istanbul.
Recognizing that record setting is as much about finding the right people as it is about radical design ideas, the SpeedDream team feel that coming to the very heart of competitive inshore racing where the best sailors compete is a natural fit for them. 'We fully appreciate that if we are in pursuit of some global records that we will need to recruit some top sailors especially those who are used to high speeds,' said Project Leader Vlad Murnikov. 'Clearly those sailors who race the Extreme 40's in such close high speed competition are amongst the best in the world, and we want to introduce them to the SpeedDream concept and see how we can all work together to set some records and broaden the overall interest in sailing.'
For more information on SpeedDream
click here
Team Tilt Crew List
Skipper / Helmsan: Lucien Cujean (SUI)
Tactician: Jocelyn Keller (SUI)
Mainsail Trimmer: Jeremy Bachelin (SUI)
Headsail Trimmer: Thomas Mermod (SUI)
Bowman: Mikis Psaarosfaghis / Jonas Schagen (SUI)
Extreme Sailing Series website
by Extreme Sailing Series
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Access (age 25 and over) and Second-Degree Checklist
For August 2015
To make your transition to life at Lynchburg as an Access (age 25 and over) or second-degree student as smooth as possible, we offer programs and events specifically for you. We're also available to answer your questions any time.
Get ready for LC in five easy steps:
Step 1: Contact Your Academic Advisor
Within a week after you pay your reservation deposit, you will receive a letter with your advisor's name and contact information. You should contact your advisor to discuss your class schedule.
Make sure you have sent your final transcripts from all previous institutions and reviewed your transcript evaluation to make sure you do not enroll in courses you do not need to take.
Before you meet with your advisor:
- Review your transfer credit evaluation and have it with you. You should receive this from the Registrar's office.
- Become familiar with the academic catalog and the course requirements for the major(s) in which you are interested.
- Come prepared with any questions you may have regarding your major, career interests, internships, etc.
In addition to helping you plan your schedule, your advisor can:
- Help you create a long-term plan for graduation
- Tell you about major-specific clubs, organizations, and other opportunities
- Advise you about opportunities for internships, research, or study abroad programs
- Help you explore post-graduate education and career opportunities
Step 2: Register for Classes Online
After you talk with your academic advisor, you can register for classes online at myLC.
You will receive instructions for how to register online from the Registrar's office. If you have any questions about online registration, please call 434.544.8218.
Please note: If a class you want is closed, speak to your advisor. Your advisor may suggest alternatives that will still help you progress along in your program.
Step 3: Submit Health Form (optional)
All full-time undergraduate students need to complete the health form regardless of whether you live on or off campus. As an Access or Second Degree student, you are not required to submit a health form, but you cannot use the health services on campus without submitting this form.
To get more information about the health center and details about the form, go to our Health Center website for required information or contact them at 434.544.8357.
Step 4: Check In to the College
All new students must check in to the College before they can attend orientation or begin classes. This is where you will get your student ID, obtain your parking pass, get the keys to your room if you are living on campus, and take care of all other campus business. (If you need a parking pass, please bring your Driver's License, proof of insurance, and car registration with you when you come to check in!)
You may check into the College in Schewel Hall from 9 a.m. - 6 p.m. on Thursday, August 13. This process usually takes about 30 minutes to complete.
Step 5: Attend Access & Second Degree SOAR
Thursday, August 13, 2015 at 6 p.m.
East Room, Burton Dining Hall (located in the Drysdale Student Center)
We look forward to meeting you and all of the other students who will be joining us for the Fall semester at our Access & Second Degree Student Orientation and Registration (SOAR)! Please feel free to bring your parents and/or guests. Registration for orientation begins at 5 p.m. in the East Room, which is located in the Drysdale Student Center.
At orientation, you will receive your official class schedule, meet with campus offices and faculty and staff, and learn about LC's academic policies and procedures. You'll also meet and interact with other new students!
Questions? Please contact us at firstname.lastname@example.com or call Academic and Career Services at 434.544.8419.


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Watch the 2014 D.I.C.E. Summit talks liveThe 2014 D.I.C.E. Summit is this week in Las Vegas and it's being streamed live this year on Twitch. Today is full of talks from folks like CCP CEO Hilmar Veigar Petursson, Vlambeer's Rami Ismail, and Insomniac Games president Ted Price. The full schedule, viewable here, should give you an idea of the types of presentations that happen at D.I.C.E. If you're wondering about the awards ceremony, that's happening tomorrow night. Check back at 7:30pm Pacific! Comments not appearing? Anti-virus apps like Avast or some browser extensions can cause this. Easy fix: Add [*].disqus.com to your software's white list. Tada! Happy comments time again.
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Wednesday, June 22
Citi Field
Attendance: 38,813
Flushing, NY (Sports Network) - A game delayed by rain that never really came ended with a breaking ball that grazed Justin Turner's shirt.
After walking Jose Reyes intentionally to load the bases in the 13th inning, Brad Ziegler clipped Turner with a slider, forcing in the winning run, as the New York Mets slipped past Oakland, 3-2, at Citi Field.
"I don't mind taking one, not in that situation. I'll stay in there and stand my ground," Turner said. "Unless it's at my face or around my ankle, I'll stay in there and take a bruise."
The game was delayed one hour, three minutes as the tarp was on the field with expected heavy storms that never really materialized.
Then a pitcher's duel broke out between R.A. Dickey and Gio Gonzalez. Each pitched well enough to win, and Dickey would have if not for Conor Jackson, who singled home the tying run in the top of the ninth. Oakland saw its six- game winning streak come to an end.
Ziegler (2-1) was saddled with the loss, while Bobby Parnell (2-1) picked up the victory with a scoreless frame. The Mets have split their last four games.
"I know the pitch was inside, it got away from me," Ziegler said. "It's just not how you want to end the game. If I'm going to lose I'd rather be beaten with a base hit."
The Mets used three consecutive hits to take the lead in the second. Scott Hairston doubled in front of Ronny Paulino's single. Lucas Duda then drilled one of Gonzalez's few mistakes, driving a fastball that ran back over the plate into right for a run-scoring single.
The A's couldn't figure out Dickey's knuckleball until the fifth as Kurt Suzuki back-legged a high fly ball that just cleared the wall in left to tie the game.
New York went ahead once Gonzalez exited the game. After the A's southpaw struck out four of the last seven batters he faced, the Mets welcomed a new hurler, Joey Devine, on the mound in the eighth. Reyes drilled a fly ball to right-center field that was deflected by the right fielder Ryan Sweeney and caromed away from him and center fielder Coco Crisp, allowing Reyes to reach third with a triple. He scored on Turner's single to left.
Crisp drove a one-out double off Francisco Rodriguez into the right-field corner in the ninth then came around to score on Jackson's two-out grounder that found eyes just past the outstretched arms of Turner. Rodriguez blew his second consecutive save for just the second time as a Met with the last coming in August 2009.
The Mets threatened in the 12th frame as Reyes chopped a one-out single to center then two straight walks loaded the bases for Jason Pridie, who grounded out to end the threat.
Alan Porter
Fieldin Culbreth
Gary Cederstrom
Adrian Johnson