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During the holiday week, Scott Coker, President of Bellator MMA, told MMAFighting.com that they have reached out to Brock Lesnar to show interest in his services. Now, just before the new year, Coker speaks of another great heavyweight the company is interested in bringing in. His hame is Fedor Emelianenko. According to a report from Tristen Critchfield of Sherdog, Coker will be in attendance at the Inoki Bom-Ba-Ye 2014 in Tokyo on New Year's Eve, and he expects to have discussions with the form read news >>
Fight Fans we hope you had a wonderful holiday with friends and family now it's time to LOCK IT INTO The SnP Show on Yahoo Sports Radio Colorado Springs Rival Radio 809. We went back in time talking about UFC Fight Night 58, discussing our favorite fights and interviews of 2014 and debating the latest MMA news to hit the headlines during this holiday week. We also were joined by a WMMA fighter Jessica Pryor who is set to make her pro MMA debut January 9th at BAMMA USA. Pryor is highly decorated read news >>
After the Christmas holiday break, the UFC returns to pay-per-view on Saturday with "UFC 182: Jones vs. Cormier" in Las Vegas – its first offering of 2015.Filed under: News, UFC, Videos read news >>
World Series of Fighting is getting some holiday love from NBC this weekend. The network will air "WSOF Unstoppable: Road to the Championship," a look back at the MMA promotion's 2014, on Saturday at 2:30 p.m. ET, MMA Fighting has learned. The show will focus on the paths that seven World Series of Fighting champions took to earn titles. "WSOF Unstoppable" will be hosted by promotion play-by-play announcer Todd Harris along with a pair of MMA legends: Bas Rutten and Renzo Gracie. It will feature read news >>
Holiday gift guide 2014 from MMAmania.com with best-of-breed brands such as Roots of Fight, Under Armour, HeadBlade, GLORY, LEONE, Anti3 Protect Series, Diamond MMA and much more. Shop 'till you drop ... read news >>
Although we're hurtling toward holiday madness and New Year's Eve, it feels like it's been forever since two title fights have graced a UFC fight card as with Saturday's UFC 181. It's one of 10 reasons to tune into the pay-per-view (...) read news >>
Looks like someone got a little overly festive this holiday season. Joe Vedepo is a longtime vet of the MMA fight scene. He made his pro debut back in 2005, and by 2008 he was fighting for the UFC. An 0-2 stint saw him get bounced to the regionals, where he made his way to Bellator, where he's competed almost exclusively since 2012. Most recently, he lost to King Mo Lawal on the main card of Bellator 131. Now, even his spot on the Bellator roster may be in jeopardy, as local Iowa City ABC affili read news >>
Hoodies are now available at the BloodyElbow.com online store. Looking for holiday gift ideas, why not pick up one (or ten) of these newly minted Bloody Elbow hoodies from our online store? The design pictured above are a minimalist version of the BE logo, along with the Heimlich-suplex banner from one of our popular features in Matwork. These two designs are also available as Men's T-Shirts and Women's V-neck shirts. You can purchase these on our online store, along with several other MMA desig read news >>
It's that time of year again: gift giving time! As the yearly calendar is set to expire in just over a month... read news >>
The upcoming Thanksgiving holiday has not slowed down UFC matchmakers Joe Silva and Sean Shelby, as four bouts have been added to the upcoming schedule. read news >>
It's going to be a busy holiday season for the Nevada State Athletic Commission, which today approved requests from UFC parent Zuffa to hold a trio of events in December and January.Filed under: News read news >>
TUF Finales and summer holiday weekend events in Las Vegas have been UFC staples for years. But both a TUF Finale and a major pay-per-view event, in the same city, and the same venue, on the same weekend? That's a new one. MMAFighting.com's Ariel Helwani reported on Wednesday's edition of UFC Tonight on FOX Sports 1 that the TUF 19 Finale will be held on Sunday, July 6, at the Mandalay Bay Events Center in Vegas. That's one day after the same building hosts UFC 175, which does not have have a si read news >>
Most fighters competing over the holiday season complain about missing Thanksgiving, Christmas or New Year's. UFC lightweight Quinn Mulhern is quite the opposite.Filed under: News, Only on Junkie, UFC Tagged: Quinn Mulhern, UFC Fight Night 34 read news >>
Even though MMA fighters batter each other inside a cage for the entertainment of millions around the globe, they are still, after all, people.Filed under: Bellator, News, Only on Junkie, UFC, World Series of Fighting read news >>


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US reports major marijuana bust at Arizona entry
NOGALES, Ariz. -- Federal authorities say agents recently made a huge marijuana seizure at a commercial truck crossing point on the U.S.-Mexico border in Nogales, Ariz.
The U.S. Customs and Border Patrol is withholding details of the seizure before a news conference scheduled Tuesday.
However, the agency says the seizure was made Jan. 15 and involved more than seven tons of marijuana with an estimated value of $7 million.
Customs and Border Patrol says it will hold the news conference will be held at the Mariposa Port and that media will be able to view the marijuana and where it was seized.
The port is a major crossing point for commercial truck traffic, particularly for produce being imported into the United States from Mexico.
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"The harder you work, the luckier you get." by Gary Player
Below is the poem entitled Death to Smoochy which was written by poet Rob Carson. Please feel free to comment on this poem. However, please remember, PoetrySoup is a place of encouragement and growth.
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This is not how I thought it would end The air is leaving me so fast I am alone, without a friend The world before me is vast My lungs are starting to burn This breath I am about to take, will be my last Forgive us our sins, just as we have forgiven those who have sinned against us. Do not let me go without correcting my wrong When they find out, my family will make such a fuss My list of sins is far too long Darkness is very near I can no longer feel There is nothing more for me to fear None of this seems real


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Jan 01, 2011, 01:44 AM | |
Joiner Boxes
The center panel to fuse alignment was done exactly like the previous planes and came out fine.
The prep for the next step involved waxing the joiners in case the resin migrated through the boxes. (it did) Taped off the joiner area to keep the overflow off the actual parts. Glued the joiner boxes in the wings. Started by mixing laminating resin, a batch of 20 and 12 grams per pair. I packed in as much chopped carbon fiber as it would take, then added some microballoon/cabosil mix to minimize the flow, then mixed it in a pot of hot water to help kick it in my cold apartment and lower the viscosity for a short time while stuffing it in the pocket. The box was inserted slowly to work out any air pockets and pack the volume completely. The excess was removed and the two parts were aligned on the table. It took a whole day to cure to satisfaction. After it cured the excess mix was cut out from between the wings. It took a bit of persuading but the two halves ultimately came apart. Next the holes were drilled for the alignment pins and the pins were glued in. Next step is to wet sand the wing LE. After that, cut the surfaces out and flex the hinge. The rudder and elevator are hooked op and working. An antenna tube was installed in case I want to use 72 mHz. If the plane was poly I could take it out and fly it right now. ImagesView all Images in thread
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What does JAB mean in Famous?
This page is about the meanings of the acronym/abbreviation/shorthand JAB in the Community field in general and in the Famous terminology in particular.
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- jab, jabbing, poke, poking, thrust, thrusting(noun)
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"JAB." Abbreviations.com. STANDS4 LLC, 2015. Web. 28 Feb. 2015. <http://www.abbreviations.com/term/542202>.
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Their stadium is seriously called "High Point Solutions Stadium."
To me, Rutgers joining the Big Ten is neither a high point or a solution.
Their stadium is seriously called "High Point Solutions Stadium."
To me, Rutgers joining the Big Ten is neither a high point or a solution.
High Point Solutions.
So...what are their problems?
(best researched using your 11W signature sarcastic eyewear)
Off-seasoning in moderation
We should have put a doomsday countdown clock on the front page, ticking down the minutes until the conference implodes with the addition of the one FBS program worse than Purdue...
If the pen is truly mightier than the sword, I may be the most dangerous man I know...
My curiosity was aroused so I went & looked up the records for all teams during the BCS era (1998-2013):
60 Purdue 0.508 101-98
61 Virginia 0.503 99-98
65 California 0.487 95-100
66 Northwestern 0.485 95-101
67 Arizona 0.485 94-100
69 Minnesota 0.482 95-102
74 Rutgers 0.474 92-102
76 Washington 0.469 92-104
77 Mississippi State 0.467 91-104
78 Wake Forest 0.461 89-104
79 Syracuse 0.459 89-105
83 Colorado 0.434 86-112
84 North Carolina 0.430 77-102
86 Iowa State 0.421 82-113
89 Washington State 0.406 78-114
90 Kentucky 0.404 78-115
92 Illinois 0.398 76-115
94 Kansas 0.393 75-116
97 Baylor 0.384 73-117
108 Vanderbilt 0.353 67-123
110 Indiana 0.332 62-125
117 Duke 0.254 48-141
Wake Forest is actually much higher than I expected.
Wow, I'm not sure I realized how much worse than Purdue Illinois and Indiana really are... Perhaps the Boilers should have held on to that mustache magic they had going in the Tiller/Hope era.
If the pen is truly mightier than the sword, I may be the most dangerous man I know...
Wow, I;'m actually shocked by some of these.
Always be yourself, express yourself, have faith in yourself, do not go out and look for a successful personality and duplicate it.
Bruce Lee
these win pct get even worse when you eliminate games against FCS schools
Purdue - take away 8 wins so against FBS they are 93-98, or .487
NW 7 wins 1 loss for 88-100, or .468
Minny - 9-3 for 84-99 or .459
Rutgers - 12-2 so adjusted 80-100 or .444
Illinois - 10-0 adjusted 66-115 or .365
Indiana - 10-1 adjusted 52-124 or .295
note that each of them has played at least 8 such games in the last 18 years and they all still suck
now note the upper half of the conference
OSU - 3 games 3-0
UM - 3 games 2-1 (haha) with another this year
Neb - 7 games 7-0
MSU - 4 games 4-0
PSU - 5 games 5-0 (ignoring vacated games)
Wisky - 9 games 9-0
Iowa - 8 games 8-0
now MD - 12 games 12-0
so I think it is safe to say that the eastern teams have played much tougher OOC schedules than everyone else (minus Rutgers and MD) OSU, PSU, UM and MSU have played only 15 such games going into the year or 3.5 per team
the rest have played 99 such games or nearly 1o each
night and day if you ask me
This is the team that Urbz will get that third digit on the scoreboard. Welcome to the B1G Rutgers. You suck.
-The Aristocrats!
Part of me has always wanted to see OSU play a high school team, just to see how much of a difference there is... Florida A&M seemed close last year, but I think OSU should try to best that 76-0 "contest" with Rutgers.
Now this article makes more sense ... use students for this game and save the wear and tear on the players!
"No matter where you go, there you are." B. Banzai
I know the idea was TV markets, so why not NY and Boston? Get Syracuse and BC, I think both would have been better options imo.
Dustin Fox was our leading tackler as a corner.... because his guy always caught the ball.
Rutgers has delivered the NY market. Deals have already been signed with the major providers to get the BTN on basic cable in the city. Having Ohio State, TSUN & PSU regularly playing 30 miles from Manhattan is going to be a much bigger draw in NY than games at Syracuse.
Leaving the AAU has also effectively killed any chance Syracuse has of joining the B1G.
From everything that I've seen nobody in Boston cares about BC.
I'm no more thrilled about Rutgers than anyone else, but from a business standpoint it really was a good long term addition. I just wish it didn't come attached with people from New Jersey.
On a positive note, now the B1G can claim to be where football originated (Rutgers & Princeton in 1869 is generally considered to be the 'first' college football game).
What would it take to schedule them the one of the first three games of the season for the warm up?
Nothing like dancing on the field in 02...


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Congressional politics: Brinkmanship
Democracy in America
The Liberal Democrat surge: Getting a Clegg up
Britain's third party may soon be much more than that32
The British election: What's the difference?
Thoughts from America on the British election20
The daily take: The view from Rome
With foreign policy the subject of the next debate, one of our Democracy in America writers assesses the election from across the pond14
A surge in support for the Liberal Democrats leaves the other parties searching for an effective counter-attack17
The coming days: The week ahead
Britain's party leaders discuss foreign policy in a televised debate10
The daily take: The oxygen of publicity
The Liberal Democrats did best out of Britain's first election debate21
Beneath the common obfuscation, the argument of the election takes shape8
This week's campaign quirks and unintended revelations2
the manifestos: The debate begins
The nasty mood of Labour's manifesto launch3
Election in the UK: Britain's choice
Voters deserve a more radical vision than the timid and uninspiring policies all parties have put forward so far50
This general election marks the end of an era. What comes next is rather less clear27
The first crop of memorable moments3
The election race: They're off!
Why the campaign will count in a contest that matters2
The grey vote: Meet the grandparents
Old people go to the polls in droves, but often need government help the least0
MPs haven't been re-elected yet, but they are already inviting you to sack them9
A briefing on the British election: The feel-bad recovery
The question is whether, in difficult times, a dubious record is better than no record at all3
A briefing on the British election: Firefighting
Tame the City, yes, but don't extinguish it2
A briefing on the British election: Back to the barricades
With money scarce, helping the poorest will be harder1
The beginning of the end5
The British election: The road to Downing Street
A closely-fought election campaign will be short on big ideas but long on excitement and ferocity36
Interview with David Cameron: Does he have what it takes?
The Conservative leader is still the favourite to be Britain's next prime minister3
Gordon Brown faces disaster and David Cameron triumph—or is it the other way around?3
David Cameron: Does he have what it takes?
The Conservative leader, David Cameron, is still the favourite to be Britain's next prime minister25
strange days: Strange days indeed
The indestructible prime minister18
Class and politics: The misinterpreted middle
Britain's teeming but invisible average earners will decide the coming election. Neither David Cameron nor Gordon Brown seems to understand them12
Congressional politics: Brinkmanship
Democracy in America
Goya's drawings: Album of the year
The American economy: Steady on
Free exchange
Investing and markets: Get your income here
Buttonwood's notebook
Daily chart: Korea opportunities
Graphic detail
Adultery in South Korea: Dead scarlet letter
Exceptionalism: The divine purposes of America and Russia
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We asked you how you would be celebrating the year of the sheep. Here is a selection of your 2015 Chinese New Year pictures from across the world.
Before they became friends, Simon Hirst was Tony Blackburn's biggest fan. And when Simon chose to have a sex change, Tony lived up to his nickname as her 'radio dad'
When Gavan Naden's son was born the day Labour swept to power in 1997 after 18 years of Conservative rule, he seemed to embody a bright future ahead, but does Oscar feel the same way about politics as his dad?
Je Suis Charlie
In solidarity with the victims of the Paris attacks, the Guardian has designed two commemorative badges. All proceeds go to those directly affected
General knowledgeGeneral knowledgeThe daily quiz: Shakespeare and The Simpsons
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Pierce Thiot and his wife Stacy Thiot have a strange hobby: they take a silly object, see if it can be lodged in his beard, then photograph the results


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Used Cars: 2011 Affordable Midsize Cars
View the best 2011 Affordable Midsize Cars based on our rankings. Then read our used car reviews, compare specs and features, and find 2011 Affordable Midsize Cars for sale in your area. Learn more about our rankings»
Related Lists:
2011 Chevrolet Malibu
The 2011 Chevrolet Malibu's good fuel economy, spacious interior and high safety scores make it a solid ... Read full review »
2011 Toyota Prius
The 2011 Toyota Prius' superior fuel economy ratings, high safety scores, exceptional reliability and spacious interior helped ... Read full review »
2011 Honda Accord
The 2011 Honda Accord is a very good choice among 2011 midsize cars, thanks to its high safety and reliability ratings. Although the Accord's trunk is smaller ... Read full review »
2011 Toyota Camry
The 2011 Toyota Camry's strengths include a good reliability rating, and when it was new, auto critics said that the 2011 Camry is a sensible, roomy and ... Read full review »
2011 Toyota Camry Hybrid
Though it doesn't have the highest fuel economy ratings among its hybrid rivals, the 2011 Toyota Camry Hybrid delivers good reliability, a spacious cabin and an enjoyable ... Read full review »
2011 Ford Fusion
Sensible, yet fun to drive, the highly-ranked 2011 Ford Fusion is a great choice for used car ... Read full review »
2011 Ford Fusion Hybrid
The 2011 Ford Fusion Hybrid delivers excellent fuel economy and a spacious interior to used car shoppers who prioritize family-sedan practicality and saving gas. Its high reliability ... Read full review »
2011 Nissan Altima
Reviewers agreed that the 2011 Nissan Altima is one of the most fun midsize family cars to drive. However, rivals outshine the Altima with better interiors and ... Read full review »
2011 Hyundai Sonata
After a full redesign, the automotive press agreed that the 2011 Hyundai Sonata was a top contender in its class. The Sonata's bold styling, spacious, well-equipped interior ... Read full review »
2011 Mazda Mazda6
The 2011 Mazda6's sleek exterior lines and sporty handling help it stand out from the pack of 2011 midsize cars. In addition to the Mazda6's fun factor, ... Read full review »
2011 Nissan Altima Hybrid
Test drivers said the thing they liked most about the 2011 Nissan Altima Hybrid is that it drives like a regular gas-only Altima, which is a big ... Read full review »
2011 Suzuki Kizashi
The 2011 Suzuki Kizashi is often overlooked in its class, but reviewers agreed that it has a lot to offer, including an upscale interior, available all-wheel drive, ... Read full review »
2011 Hyundai Sonata Hybrid
Strong performance, good fuel economy, attractive styling and a roomy, well-equipped interior not only make the 2011 Hyundai Sonata Hybrid a good used hybrid car, but a ... Read full review »
2011 Kia Optima
The Kia Optima received a full redesign for 2011 and reviewers were impressed with the changes Kia made. High on their list of pros were its sleek, ... Read full review »
2011 Subaru Legacy
Standard all-wheel drive, high safety scores and a roomy cabin make the 2011 Subaru Legacy a solid 2011 midsize car, especially if you take the occasional trip ... Read full review »
2011 Mitsubishi Galant
The 2011 Mitsubishi Galant is a satisfactory commuter car with a roomy cabin and good reliability ratings. The Galant's subpar powertrain, cheap interior materials and low safety ... Read full review »
2011 Chrysler 200
The 2011 Chrysler 200 sedan is an acceptable used midsize car, but the automotive press agreed that besides it high safety scores, most competitors outshine the 200 ... Read full review »
2011 Kia Optima Hybrid
As Kia's first hybrid car, reviewers said the 2011 Optima Hybrid adds great fuel economy to all of the gas-only Optima's favorable traits. On the other hand, ... Read full review »
2011 Dodge Avenger
Despite numerous updates and high safety scores, the 2011 Dodge Avenger's low reliability rating, second-rate performance and cheap cabin materials keep it from becoming a competitive entry ... Read full review »
Safety scores should only be compared between vehicles of similar size and weight. Larger, heavier vehicles generally provide more protection than smaller, lighter ones.


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Everything Las Vegas
When temperatures hit triple digits in July and August, there's no way you can visit a Las Vegas pool without taking a dip. But if a leisurely, quiet float on a raft isn't quite what you had in mind, a fist-pumping adult day club pool and endless frozen libations might be more your speed during….
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Nigeria's Goodluck Jonathan faces first significant political crisis
(Read article summary)A spirit of cooperation among Nigeria's elites seems scuttled as blistering critique of Mr. Jonathan is leaked by former president.
Richard Drew/AP/File
A version of this post originally appeared on the Africa In Transition blog. The views expressed are the author's own.
On Dec. 2, former Nigerian President Obasanjo sent a letter to current President Goodluck Jonathan cataloging the shortcomings of the latter's administration.
Eighteen pages in length, it is a thoroughgoing indictment of the Jonathan administration, cataloging shortcomings ranging from security to corruption to the president's leadership of the ruling Peoples Democratic Party.
Altogether, Mr. Obasanjo's letter is a familiar critique of Nigerian governance under Jonathan, if perhaps more bluntly stated than is usual in public among Nigeria's establishment.
Though ostensibly private, the letter soon appeared in the media, and it looks as though it was Obasanjo's intention that it should eventually become public.
In a letter dated Dec. 20 that appeared in the media on Dec. 22, Mr. Jonathan replied. While Jonathan said he would not provide a point-by-point response, his reply is lengthy and detailed. His bottom line: "…you have done me grave injustice with your public letter in which you wrongfully accused me of deceit, deception, dishonesty, incompetence, clannishness, divisiveness, and insincerity, amongst other ills."
The two letters, read together, constitute a debate on the state of Nigeria.
There are very few points of agreement between the two men. Jonathan flatly denies some of Obasanjo's most pointed accusations, e.g., that the sitting president has developed a "security watch list" with a thousand names on it.
Jonathan notes that Obasanjo's claim that almost $50 billion in oil revenue is unaccounted for is "spurious," and based on a letter from the governor of the Central Bank of Nigeria, Lamido Sanusi, that (per Jonathan) its author now says is "misconstrued."


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Wayside's 'Wait Until Dark' perfect for the season
Middletown — Wayside Theatre's "Wait Until Dark" is the perfect production for this time of year with a mix of suspense and mayhem and frightening characters.
The action builds until the final scene when the audience isn't sure if the main character survives the terrifying ordeal.
Thomasin Savaiano plays that character, Susy Hendrix, a young blind woman who has to out maneuver three criminals to survive.
She does a superb job in the part, including walking around the apartment by touch with her eyes wide open. It was an amazing performance for someone who has the gift of sight to portray someone who does not.
She is very convincing and takes the audience on a trip of falls and blunders when she is trying to maintain her thoughts and composure among a group of shady characters who want to find something they think she has.
The plot twists and turns add to the mystery and suspense as her husband, Sam Hendrix (Darrell Johnston) leaves her alone for the day with no knowledge of what lurks around the corner.
Set in the 1960s, the story revolves around a doll Sam has been asked to bring home by a stranger. What the doll contains attracts the criminal element to the apartment.
The three bad guys — Mike Talman (Eddie Staver III), Sgt. Carlino (Jody Lee) and Harry Roat Jr. (Benjamin Reed) — come and go so often to try and trick her that the audience is left reeling from the constant door closing and multiple entrances and exits.
All three give admirable performances of shifty characters who are not above tricking the handicapped. And Roat is even capable of far-reaching deeds that go beyond the small crook category.
Natalie Youngblood as the young Gloria, a neighbor child who helps Suzy with trips to the grocery store and other tasks.
Youngblood is very effective and convincing as a rather precocious 9-year-old youngster, who is fearless and whose actions affect the outcome of the story.
But one of her deeds actually caused most of the action and events of the plot.
Youngblood shares the role with Vivian Sansoni but played Gloria Sunday for the opening of the fourth production of the 51st season.
The stage was functional with the New York City Greenwich Village apartment set up for someone who can't see. It used the entire space with living room and kitchen visible.
Sets by Zach Fullenkamp were authentic with period appliances and furniture and a functioning window blind that sends signals.
Music by sound designer Steve Przybylski adds an element of suspense and intrigue especially as the movement is impeded by the lack of sight.
Lighting by Wes Calkin is crucial to the plot as the action in the final scene is in total darkness and no one knows for sure the outcome — who survives and who doesn't until the light is restored.
Costumes by Caleb Blackwell are effective and functional as thieves portray upstanding citizens.
The production, directed by Rebecca Calkin, is slow the first half but quickly moves along in the second. It is definitely a must-see for those who want a fright for Halloween and to find out who survives.
"Wait Until Dark" continues through Nov. 3. For tickets, contact 540-869-1776 or visit waysidetheatre.org.


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Osteoporosis has been an understandable concern for children and adult patients with congenital adrenal hyperplasia (CAH) who may receive or have received supraphysiological doses of glucocorticoids. Some previous reports on bone mineral density (BMD) in adult CAH patients showed no significant differences in BMD between patients with CAH and controls, but others have found lower BMD in CAH patients. In reports documenting the BMD reduction, this outcome has been attributed to an accumulated effect of prolonged exposure to excess glucocorticoids during infancy and childhood. We recently conducted a trial to establish the role of the total cumulative glucocorticoid dose on BMD. We established for the first time that there was a negative relationship between total cumulative glucocorticoid dose and lumbar and femoral BMD. Women might benefit from the preserving effect of estrogens compared to men. BMI (Body Mass Index) also appeared to protect patients from bone loss. In light of this, physicians should bear in mind the potential consequences of glucocorticoids on bone and therefore adjust the treatment and improve clinical and biological surveillance from infancy. Furthermore, preventive measures against corticosteroid-induced osteoporosis should be discussed right from the beginning of glucocorticoid therapy.
1. Introduction
Congenital adrenal hyperplasia (CAH, MIM 201910) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Many different mutations of the CYP21 gene have been identified causing varying degrees of impairment of 21-hydroxylase activity that result in a spectrum of disease expression [1]. Most patients are compound heterozygotes, and the clinical phenotype is generally related to the less severely mutated allele and, consequently, to the residual 21 hydroxylase activity.
Indeed, CAH is classified according to symptoms and signs and to age of presentation. The clinical phenotype is typically classified as classic for the severe form, or non-classic (NCF) for the mild or late-onset form. Classic CAH is subclassified as salt-wasting (SW) or simple-virilizing (SV) forms, reflecting the degree of aldosterone deficiency. Current treatment is intended to reduce excessive ACTH and consequent increase in androgen production by substituting for deficient cortisol synthesis and, when necessary, mineralocorticoid substitution. During childhood, the main aims of the medical treatment of CAH secondary to 21-hydroxylase are to prevent salt loss and virilization, to achieve normal stature, and to undergo normal puberty [2]. Undertreatment exposes the patient to the risk of adrenal crisis and allows increased adrenal androgen production, with consequent advancement of bone age and loss of growth potential. Overtreatment, however, results in growth retardation, truncal obesity, and osteopaenia, through the effects of steroids on growth hormone secretion and bone metabolism. In adulthood, the aims of the medical treatment are to substitute cortisol and, when necessary, aldosterone deficiency, to ensure normal fertility, and to avoid the long-term consequences of glucocorticoid use. In such an intervention, there is a narrow therapeutic window through which the intended results can be achieved. Indeed, other states, as Cushing's syndrome and pharmacological glucocorticoid therapy, can affect peak bone mass in growing individuals and generate osteoporosis via multiple mechanisms, resulting in increased bone resorption and suppression of bone formation. Chronic glucocorticoid therapy is known to generate bone loss in many ways: a direct suppression of osteoblastic activity [3] and an inhibition of digestive calcium absorption with secondary hyperparathyroidism and increased bone resorption by osteoclasts [4]. Glucocorticoids also lead to an inhibition of intestinal calcium absorption and an increase of renal calcium excretion leading to secondary hyperparathyroidism [5].
2. Bone Mineral Density Studies in Children and Adults with 21 Hydroxylase Deficiency: Results and Limitations
Based on these findings, many studies have attempted to analyse bone mineralization status in patients with 21-hydroxylase deficiency, with the precise goal of identifying bone demineralization (Table 1). Some studies reported no significant differences in bone mineral density (BMD) between patients and controls as measured by DXA [6–11] whereas others found lower BMD or bone mineral content in all or some subpopulations of CAH patients [12–21]. These contradictory results may be explained by heterogeneous populations and methods, as the reports differ with respect to age selections and glucocorticoid regimens. Indeed, a couple of studies included pre- and postpubertal patients who had not yet reached their final height, while others sought to compare BMD with average glucocorticoid dose, at the time of the study.
Table 1. Summary of literature involving adult bone mineral density studies in CAH patients.
The age of the patients is an important confounding factor in the study of BMD in CAH patients. Only four studies have evaluated BMD in prepubertal and in adolescent patients with the salt-wasting form of CAH [7, 14, 15, 21]. Gussinyé et al. studied 16 children, 1.5 to 8.3 years old, 17 young adults, 17 to 28 years old, and a control group [7]. The average doses of hydrocortisone (mg/m2 body surface/day) received from diagnosis in the neonatal period to BMD evaluation were 21.2 ± 2.2 and 22.3 ± 2.6, respectively. Mean BMD Z score values did not show statistically significant differences with age- and sex-matched controls. Nevertheless, 4 of these children have BMD less than −1 SD. Cameron et al. concluded also that replacement therapy with glucocorticoid and mineralocorticoid hormones were not deleterious in terms of general bone mineralization in 21 CAH patients (aged 8–32 yr) [14]. Paganini et al. showed on 50 CAH patients (23 males, 27 females), aged 1–28 years, that an impairment in bone growth and mineralization may be found in young adults but not in children affected by the classical form [15]. Nevertheless, Zimmermann et al. [21] found reduced Z-score (≤−1 SD) in 60.8% of the patients, with a percentage of 61.5% in the SW form (8/13 patients, age 5 to 17 years), and 60% in the SV form (9/15 patients, age 5.1 to 39 years). Conversely, only four studies included patients older than 50 years [6, 12, 17, 20], among which two found BMD alteration in CAH patients, that tends to be correlated with hydrocortisone dose.
DXA measurements of BMD depict areal bone density, and bone thickness is not considered. This can lead to an underestimate of BMD in small and an overestimate in large bones. A recent study has calculated BMAD (g/cm3) with formulas reported to reduce the confounding effect of bone size [20]. Even with this approach, bone density was significantly reduced in their patients at all measured sites, indicating that the differences found were real and not only due to measurement bias. This is also supported by the finding in this study that the patients and controls with normal height (160–169 cm) had the same differences in BMD, as was found in the entire study population [20]. Still, in very short individuals, an overestimation of osteopenia/osteoporosis may occur with conventional DXA measurements. However, DXA remains a useful tool for followup in the management of individual patients. Of interest, short stature by itself observed in some CAH patients might also be a risk factor for fractures, as small bones may be less resistant to mechanic restraints. Conversely, overweightness, obesity, and hyperandrogenism seem to be protective on BMD [19].
In studies showing alteration of BMD, Z-score, or T-score, it has been showed to be less than −2,5 SD in 0% to 18% of the CAH patients and between −2,5 and −1,0 SD in 13% to 52% of the patients [12, 16, 17, 19]. This low BMD might be explained by glucocorticoid overtreatment itself or by suppression of androgen levels due to glucocorticoid overtreatment, and/or by premature puberty and hypogonadism induced by undertreatment or some antiandrogen treatment. However, few studies have extensively studied the link between BMD alteration and glucocorticoid dose [12–14, 17, 19, 21], as it is possible that androgen deficiency per se may be of importance for the development of low BMD, in addition to the direct catabolic effects of glucocorticoids on bone. This may be especially important in postmenopausal women.
In reports documenting the BMD reduction, this outcome has been attributed to an accumulated effect of prolonged exposure to excess glucocorticoids during infancy and childhood. The role of each of these factors has been evaluated in a number of studies published over the last decade, often with conflicting results. Most studies are retrospective, include mixed populations (children and young adults), have a small sample size, and are unable to precisely assess the effect of cumulative glucocorticoids doses. For example, Jaaskelainen and Voutilainen [12] chose a current and mean long-term glucocorticoid dose, Hagenfeldt et al. [13], an index of accumulated postmenarchal glucocorticoid medication, Sciannamblo et al. [18], the median of the last seven years of treatment, and Stikkelbroeck et al. [9], a cumulative dose which was calculated exactly over 0.5, 2, and 5 yr preceding the investigation. Thus, some authors do not find a correlation of BMD with the present glucocorticoid dose [18], with the cumulative dose calculated for the last 2 years [6], or for the last 7 years [18], with the duration of treatment [6], or with the age of treatment start [6].
3. Bone Mineral Density in Young Adults with 21 Hydroxylase Deficiency, in Relation to Cumulative Dose of Glucocorticoid from the Start of the Treatment
To resolve this issue, we hypothesized that there could be a negative role of the total cumulative glucocorticoid (TCG) dose on BMD. We therefore collected the data of the daily dose of glucocorticoid received from the time of diagnosis in early infancy up to the time of inclusion in our study [22]. We considered adult patients >16 years old with classical CAH and nonclassical CAH that had been revealed by precocious puberty, and who had been continuously monitored and treated since childhood. Thirty eight adult patients suffering from CAH due to 21-hydroxylase deficiency and treated since early infancy in pediatric centers were included in our study. Twenty-four of them (63.2%) have the salt-wasting form (SW) (14 women, 10 men), 5 the simple virilizing form (SV) (13.1%, women only in this group), and 9 the nonclassical form revealed by precocious puberty (23.7%, women only in this group). They had all been on glucocorticoid treatment since diagnosis in infancy and 23 of them (60.5%) were also receiving mineralocorticoid (9-fludrocortisone) during the study. The mean current dose in growth retarding hydrocortisone equivalents (1 mg of dexamethasone = 16 mg of prednisone = 80 mg of hydrocortisone) was 16.9 ± 5.5 mg/m²/d. Mean daily dose over a year could be distinguished in three periods: salt-wasters were treated with 23.8 ± 8.8 mg/m²/d the first two years of life, patients with classical (SW and SV) and nonclassical forms had, respectively, 18.2 ± 4.8 and 12.7 ± 4.1 mg/m²/d during childhood (), and 20.4 ± 6.4 and 13.8 ± 3.0 mg/m²/d during puberty (). We found a negative effect of TCG on lumbar and femoral T-scores (Figure 1). Moreover, we demonstrated the same negative effect with TAG, which represented the average daily dose of glucocorticoids that patients received over their entire therapy life-period. In fact, 44.7% of the participants had bone demineralization according to WHO criteria, which is superior to a Gaussian repartition, in which 16% of the general population is under −1 SD. These results are reinforced by the fact that patients do not always take their therapy as prescribed, notably during childhood and adolescence; in other words real glucocorticoid intakes may be sometimes lower than those written in files. Our results are reinforced by Van Staa's et al. meta-analysis which underlined a strong correlation between cumulative dose and loss of BMD, mean daily dose, and risk of fracture independently of underlying disease requiring corticotherapy, age, and gender [23]. A recent study [21] confirmed our results, showing a negative correlation between mean and cumulative glucocorticoid dose and treatment duration with BMD.
Figure 1. T-score regression lines explained by total cumulative glucocorticoid dose.TCG and lumbar T-scoreTCG and femoral T-score
We found fairly normal pubertal development in boys (11.6 ± 1.6 years) and girls (10.3 ± 1.8 years) and a mean age of menarche around 13.6 ± 1.6 years, which had also been reported by Hughes and Read [24] and Bonfig et al. [25]. We noted low final height compared to target height, consistent with former publications [26–28], while onset-pubertal height was normal. Height gain was also reported as poor during pubertal years in studies conducted by Stikkelbroeck et al. [29] and Van der Kamp et al. [30].
4. Bone Mineral Density in Relation to Puberty, Hormonal Status, Glucocorticoid Treatment, and Height
This underlines the fact that the impact of glucocorticoid/androgen balance is more important than altered puberty development in this population. Firstly, hyperandrogenism during infancy due to undertreatment leads to growth velocity acceleration and a premature closure of epiphysial plates [14]. Conversely, overtreated children suffer from growth retardation [10, 31]. One may wonder whether peak bone mass acquired during puberty might be affected by this therapy as total pubertal growth diminishes. Indeed, we underlined that BMD was mostly affected by the glucocorticoid therapy during puberty. This corroborates Gussinye's work in which BMD values of adolescent and young adult CAH patients were significantly lower than those of the age- and sex-matched controls whereas it did not differ between prepubertal patients and controls [7]. Secondly, glucocorticoids may lead to osteoporosis [32], while androgens are known to increase bone formation markers [33, 34]. Many studies have pointed out that normal endogenous cortisol production is around 7 mg/m²/d in healthy people [35, 36] whereas clinicians advocate 10 to 15 mg/m²/d of exogenous therapy [37], which can bring on corticosteroid side effects in bones and result in subnormal androgen levels. In light of this, nonclassical CAH had better BMD than classical CAH groups, and their TAG were lower. Similarly with the literature, no correlation was found between BMD and hormonal parameters, probably because hormonal concentrations reflect a punctual measurement, while the BMD values are the integrated result of a long-term process.
5. Sexual Dimorphism for the Impact of Demineralization in Patients with 21 Hydroxylase Deficiency
We observed a large discrepancy between lumbar and femoral T-scores between women and men in this study. Authors of published papers explained that estrogens have a more protective action for bone mineralization than androgen [33, 38], which could contribute to this result, all the more since the majority of women took exogenous estrogens. In addition, it appears that adult males with CAH face a dual problem: (1) adrenal steroid overproduction, especially androgen and progesterone which are less protective on BMD than testosterone, might interfere with FSH and LH production, resulting in gonadotropin deficiency and consequent small testicular size and lower testosterone levels [39, 40], and (2) adrenal rests can interfere directly with the endocrine function of normal testicular tissue in a mechanical way or by local steroid production. Furthermore, supraphysiological doses of glucocorticoids can inhibit gonadotrophic axis and also deprive bone of the protective role of testosterone. We showed that BMD in women taking exogenous estrogens were similar compared with those who were not under estrogen therapy. Nevertheless, we did not distinguish between different hormonal treatments, their duration, or the periods over which they were administered. Finally, our population was fairly young at 24.6 ± 5.9 years, the oldest patient being 39. It is recognized that men and premenopausal women may suffer from glucocorticoid-induced osteoporosis [41, 42], and postmenopausal women also have a high risk of fracture during corticosteroid treatment [43].
6. Fractures in Patients with 21 Hydroxylase Deficiency
Osteoporosis is a strong risk factor for fractures, but only one study has evaluated fractures in CAH patients [20]. This study included 61 women, aged 18–63 yr, 27 with salt wasting, 28 with simple virilizing, and 6 with nonclassical 21-hydroxylase deficiency. A total of 61 age-matched women were controls. Results indicated a higher frequency of fractures in women with CAH. When only osteoporotic fractures (vertebrae, wrist, and hip) were considered, the difference almost reached significance (). This is of importance for CAH patients, even if this finding has to be confirmed in larger studies, which should evaluated differences in lifestyle between patients and controls, as the trauma leading to fractures was not ascertained. This is in accordance with a study showing increased risk of fractures in patients receiving glucocorticoid therapy, even with low dose [44]. We may then suppose that aging patients with CAH are at risk of fracture; therefore, preventive methods might be introduced, including physical activity and diet-recommendations and vitamin D supplementation if necessary [45].
7. Bone Turnover Markers in 21 Hydroxylase Deficiency
Biochemical markers of bone turnover have also been partially evaluated in patients with CAH [6, 10, 15, 18, 20], and literature data are inconclusive. Bone turnover was found to be lower in patients with CAH than in controls, and osteocalcin levels correlated positively with growth velocity and negatively with BMD [6, 10]. Another recent study showed higher bone-specific alkaline phosphatase (ALP) and serum -C-telopeptide of type I collagen (CTX) concentrations in CAH patients compared with control subjects, but this did not correlate with the actual glucocorticoid dose or the mean dose used during the previous 7 yrs [18]. The bone resorption marker CTX was recently reevaluated [20]. It was reduced in the older group of patients both compared with controls and younger patients. This was not in accordance with the findings of Sciannamblo et al. [18] and of Zimmermann et al. [21] that observed elevated CTX concentrations in young individuals, some still growing. The authors concluded that the CAH patients treated for many years had predominantly low bone formation but also unexplained low bone resorption [46]. Regarding the parameters of bone mineralization, a few patients of the study by Falhammar et al. exhibited PTH levels above the upper level of the reference range concomitant with low normal calcium concentrations, and they were all osteopenic [20]. This can be interpreted as secondary hyperparathyroidism, likely attributable for the authors to glucocorticoid therapy. However, the 25-hydroxyvitamin D levels were not assessed in this study.
Finally, possible role of GH has been assessed. Indeed, glucocorticoid administration may affect the growth axis in CAH in several ways. While CAH patients have normal responses to provocative GH stimulation testing, it has been suggested that the pattern of GH release changes with the administration of glucocorticoids [47]. However, normal IGF-I levels are reported in the majority of studies [30]. Noteworthy in Falhammar et al. study, CAH patients had higher IGF-I SDS compared with controls and the authors interpreted this phenomenon as a state of IGF-I resistance induced by glucocorticoids, and speculate that this could be a explanation for growth retardation in children on glucocorticoids.
8. Conclusions
Despite these conflicting results in the literature, and because some studies showed that young adult patients with the classical form of CAH have decreased bone density values compared with healthy controls and that this may put them at risk of developing osteoporosis early in life, CAH patients should be considered at risk for osteoporosis and fractures and physicians have to systematically check BMD in CAH adult patients. Furthermore, even if no interventional therapeutic study exist in CAH patients, preventive measures against corticosteroid-induced osteoporosis should be discussed right from the beginning of glucocorticoid therapy. Osteoporosis prophylaxis such as physical activities and calcium and vitamin D supplementation should be implemented. Therefore, Vitamin D status should systematically be determined in CAH patients and calcium and vitamin D supplementation recommended in patients with vitamin D deficiency and in those receiving high dose of steroids. The frequency of such measures during adulthood remains unresolved, and probably depends on the initial result of the BMD. The results obtained in adults are an incentive to follow bone mineral density in children, using the right normative data and expression of the results as Z score. Adequate calcium and vitamin D intake, in relation to the age of the child, should also be given. Finally, in accordance with the literature, optimizing the doses of glucocorticoids should always be the primary option in CAH patients.
Our studies were partially supported by a three-years grant from "Association Surrénales," France, http://asso.orpha.net/AGS/cgi-bin/lassociation.
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Linder BL, Esteban NV, Yergey AL, Winterer JC, Loriaux DL, Cassorla F: Cortisol production rate in childhood and adolescence.
Journal of Pediatrics 1990, 117(6):892-896. PubMed Abstract | Publisher Full Text
Clayton PE, Oberfield SE, Martin Ritzén E, Sippell WG, Speiser PW, Hintz RL, Savage MO: Consensus: consensus statement on 21-hydroxylase deficiency from The Lawson Wilkins Pediatric Endocrine Society and the European Society for Pediatric Endocrinology.
Journal of Clinical Endocrinology and Metabolism 2002, 87(9):4048-4053. PubMed Abstract | Publisher Full Text
Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K: Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.
Journal of Clinical Endocrinology and Metabolism 1995, 80(12):3689-3698. PubMed Abstract | Publisher Full Text
Cabrera MS, Vogiatzi MG, New MI: Long term outcome in adult males with classic congenital adrenal hyperplasia.
Journal of Clinical Endocrinology and Metabolism 2001, 86(7):3070-3078. PubMed Abstract | Publisher Full Text
Stikkelbroeck NMML, Otten BJ, Pasic A, Jager GJ, Sweep CGJ, Noordam K, Hermus ARMM: High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia.
Journal of Clinical Endocrinology and Metabolism 2001, 86(12):5721-5728. PubMed Abstract | Publisher Full Text
Adinoff AD, Hollister JR: Steroid-induced fractures and bone loss in patients with asthma.
The New England Journal of Medicine 1983, 309(5):265-268. PubMed Abstract | Publisher Full Text
Michel BA, Bloch DA, Wolfe F, Fries JF: Fractures in rheumatoid arthritis: an evaluation of associated risk factors.
Journal of Rheumatology 1993, 20(10):1666-1669. PubMed Abstract
Van Staa TP, Laan RF, Barton IP, Cohen S, Reid DM, Cooper C: Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy.
Arthritis and Rheumatism 2003, 48(11):3224-3229. PubMed Abstract | Publisher Full Text
Van Staa TP, Leufkens HGM, Abenhaim L, Zhang B, Cooper C: Use of oral corticosteroids and risk of fractures.
Journal of Bone and Mineral Research 2000, 15(6):993-1000. PubMed Abstract | Publisher Full Text
American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis : Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis.
Arthritis and Rheumatism 2001, 44(7):1496-1503. PubMed Abstract | Publisher Full Text
Canalis E, Bilezikian JP, Angeli A, Giustina A: Perspectives on glucocorticoid-induced osteoporosis.
Bone 2004, 34(4):593-598. PubMed Abstract | Publisher Full Text
Charmandari E, Pincus SM, Matthews DR, Johnston A, Brook CGD, Hindmarsh PC: Oral hydrocortisone administration in children with classic 21-hydroxylase deficiency leads to more synchronous joint GH and cortisol secretion.
Journal of Clinical Endocrinology and Metabolism 2002, 87(5):2238-2244. PubMed Abstract | Publisher Full Text


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Intendant Alexander Pereira halts the merry-go-round briefly to discuss Salzburg and La Scala with Zachary Woolfe of the New York Times.
Javier Camerena, "as close to a rock star as the Met has produced from its male roster this season," has big plans with the company, with at least four roles planned for future seasons. [New York Times]
To celebrate the birthday of Renata Tebaldi, our friends at Opera Depot are offering a free download of live performances by this great diva. And speaking of divas, Our Own JJ returns to Operavore this afternoon for a talk about operatic miscasting. And don't miss Zachary Woolfe's fascinating look at the Met's new and different Prince Igor in the New York Times.
"But like any production left out in the sun a few decades, it gradually faded into mere decoration."
The much-anticipated Stefan Herheim production of Les Vêpres Siciliennes opened last night at the Royal Opera, and the New York Times' Zachary Woolfe was something less than completely bowled over.
Longtime Friend of the Box Zachary Woolfe (pictured) sits down with Marc Scorca of Opera America for a "Conversation about Opera in America," implausibly enough.


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Mom and Pop Move Their Comic Shop! – KICKSTARTER
Mom & Pop Move Their Comic Shop! All About Books & Comics has been in business in Central Phoenix for 33 years. Unfortunately, we recently lost our lease. Our family-owned comic shop is being forced to move locations. We've launched a Kickstarter Campaign to help crowd-fund this costly venture of moving a million comics and setting up a new store. Visit our Kickstarter Page Here ENDS WED. MARCH 11th at 5PM AZ time! We have tons of Great Rewards and Perks! Check them out on the Kickstarter Page! Comics, Limited Edition T-shirts, VIP events, and More! You can follow our … Continue reading
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Great things are happening in 2015! All About Books and Comics is Turning the Corner! Literally! This June we will be moving around the corner! Same Great Store, in a NEW GREAT location! Lots of convenient parking right out front. Walking distance from our current location. A newly expanded Discount Comics Hub and more! Join our mailing list or watch here on our website as well as on Facebook and Twitter for details in the coming months. Continue reading
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Subscribe for ONLY $1 an Issue
That's $10 for an entire year!
Hispanic Heritage Month begins September 15, and President Obama is kicking off the month-long celebration in a major way!
The White House will be hosting a concert event honoring Latin music on September 16. There will be performances by Ricky Martin, Gloria Estefan, Lila Downs, Romeo Santos, Alejandro Sanz, Prince Royce, Natalie Cole, Marco Antonio Solis, Arturo Sandoval and Raul Malo.


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The Zen Works of Stonehouse: Poems and Talks of a Fourteenth-century Chinese HermitOne of the classic texts of Zen, essential for anyone interested in Zen practice and tradition. Stonehouse has been called "the greatest of all Zen monks who made poetry their medium of instruction." Until now his works have rarely been available in English. Now all of the hermit monk's poetry, including the major poetic works, "Mountain Poems" and "Gathas," as well as his most illuminating instructional talks, can be read in Pine's superb translations. According to Nelson Foster and Jack Shoemaker in "The Roaring Stream: A New Zen Reader," "The ancient Taoist themes of simplicity, naturalness, and ease resound in Shih-wu's [Stonehouse's] writing, ringing out clearly within the Ch'an [Zen] setting. Everything in his mountain life that might seem a hardship to others-very plain food, crude and cramped quarters, dearth of human contact-Shih-wu celebrates as an outright virtue or at least preferable to what a city dweller can know.... Shih-wu packed his verses with practice pointers and encouragements, enticements and goads, allusions to sutras and Ch'an stories." With Red Pine's personal discovery in 1991 of the site of Stonehouse's former hut, this edition provides rare first-hand understanding of the spiritual and physical realm of Stonehouse's era. "Every Zen student will wish to own a copy."-Jim Harrison "An admirable achievement!"-Burton Watson Red Pine is the pen name of Bill Porter. Translator of numerous classical Chinese texts, he lives in Port Townsend, Washington. |
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The Zen Works of Stonehouse: Poems and Talks of a Fourteenth-Century Chinese Hermit
User Review - Not Available - Book VerdictHere Emshwiller ostensibly continues the story of the Ladd family, begun in Ledoyt. However, this sequel concentrates on the experiences of Mary Catherine, who has come to the Ledoyt ranch to tutor ... Read full review
Review: The Zen Works of Stonehouse: Poems and Talks of a 14th-Century Chinese Hermit
User Review - Carolyn - GoodreadsThe poems are beautiful - evocative of the satisfied hermit's life. The gathas are sometimes enigmatic, with obscure references, but all illuminated by Red Pine's generous footnotes. You feel the very ... Read full review
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- 7200 RPM 64MB Cache
- SATA 3.0Gb/s
- 5 years limited
Absolutely horrible 02/20/2012
This review is from: Western Digital Black WD2001FASS 2TB 7200 RPM 64MB Cache SATA 3.0Gb/s 3.5" Internal Hard Drive Bare Drive
None when 1/3 of them fail within the first year
Bought 6 of these on1/14/11 to use in a RAID 5 array. Paid extra for Caviar Black 5 year warranty expecting good drives. 1 failed after 11 months, and another failed after 12 months. Tons of data was lost.
Other Thoughts:
rated 1 star because it won't let me give it zero stars
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Navy wife and homeschooling Momma to three Secret Agents. Loves coffee, chocolate, and all things Disney.
Sunday, March 24, 2013
Posts That Never Get Written
8 comments :
Oh yes. Yes. Yes. Yes. Especially number one. I cannot tell you how often that happens to us!-The Dose Girls
ReplyDeleteOh the timely one, forget it. I am almost never timely. Mostly because, well, I just never have time! #3 I am much better at, because I have these little notebooks I carry around with me so if I think of something I can just write it down, otherwise I would never remember!!
ReplyDeleteDefinitely yes to ones in my head although mostly I won't let them stay there. I do have many unwritten blog post drafts, and many more notes scribbled on Post-it notes for posts I never wrote. Sometimes I eventually do them but they're totally changed by the time I write them out. And many more times, I abandon ship.
ReplyDeleteNumber three for me, all the time. Driving is when I get my best ideas. And if I'm not on my way home so I can start writing the moment I get there... GONE. Drives me nuts!


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BabyBjörn Safe Step, Grey
Product information
The Baby Bjorn Safe Step allows children to reach the toilet or sink on their own. Thanks to the wide rubber strips on the base, it's safe and secure to stand on as it will grip firmly to the floor. There's also a rubber mat on top to keep children from slipping. Easily rinsed under running water.- Brand
- Dimensions
- 35 x 24 x 15cm
- Eligible for International Delivery
Editors Notes
Founded in Sweden in 1961 with a motto of "Happy Baby, Happy Parents", Baby Björn specialise in developing safe and innovative products for babies and toddlers. They started with a single bouncer design and now their products are now sold in over 50 countries globally. To date, 30 million children have been carried in their baby carriers.
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Free from John Lewis or Waitrose shops for collection tomorrow from 2pm
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We want you to be happy with your purchase. If you're not, depending on the type of product, you can make free returns in the UK via John Lewis shops, Royal Mail, Collect+, or MyHermes. If you need to arrange collection of large or heavy items, call us on 03456 049 049. For international returns queries, call us on +44 1698 545 454. Find out more about returns.
You'll find returns information on your delivery note. Unless faulty, we'd like you to make your return within 90 days of purchase. Exceptions apply to certain products - find out more about our refund policy.
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First Official Look: Ben Stiller in 'The Secret Life of Walter Mitty'
Posted on Monday, April 15th, 2013 by Angie Han
It's been 66 years since the original The Secret Life of Walter Mitty came out, and a remake of it has been in development for about a quarter of that time. But after bouncing between various studios, directors, and leads, the project finally got a big push a couple of years back when Ben Stiller signed on to both star and direct for 20th Century Fox.
Stiller plays a Life Magazine photo editor who frequently slips into daydream, to the ridicule of his peers. The first set photos revealed last year showed Stiller aged into an old man via the magic of special effects, but in the first official still he's much closer to his own age — if not, perhaps, in his own world. Check it out after the jump.


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Many people view addiction as a weakness and that it can be overcome by willpower. However many people in the church struggle with addiction. They feel trapped – that there is no way to overcome the drug or alcohol cravings they struggle with. The truth is addiction is a disease. Individuals who struggle with addiction need to get help in order to recover. It is also important to find a treatment center that aligns with your faith. Members of the church who struggle with addiction can seek help through LDS faith-based addiction recovery centers.
LDS Faith-Based Addiction Recovery programs provide ways to work on your addiction and also strengthen your faith. They help their clients through counseling treatment and also teach gospel principles. They also help the individual to recommit to sobriety and find forgiveness through the atonement of Jesus Christ. Just like other faith-based rehab centers, LDS Faith-Based Addiction Recovery offers an individualized faith-based treatment that is designed for members of the church. This recovery program promotes gospel principles as a 12-step recovery regimen that relies heavily on the help of our Father in Heaven. We believe that a return to gospel principles as well as individualized counseling methods are the most effective way to achieve recovery.
LDS Faith-Based Addiction Recovery enables every individual to realize their potential as a son or daughter of God. The treatment procedures will enable them to find their new life and help them overcome their addiction. The following are some of the faith-based recovery treatments for you or your loved one:
We view addiction as a "Family Disease." Family members will learn how they can help their loved one through their recovery. Family members will also come to a better understanding of addiction and the role that they must play in their loved one's recovery. LDS Faith-Based Addiction Recovery Centers offers gospel centered support which is designed to strengthen faith and help with the recovery.
If you or your loved one is struggling with addiction, LDS Faith-Based Addiction Recovery centers are here to help. You will get the spiritual support and the gospel centered treatment you need.
© Talbot 2015


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WILSON, N.C. — Remember the overtime, buzzer-winning lay-ups by Barton point guard Anthony Atkinson, the "We Believe" chants by the fans that raised the rafters in the Dog House, and the emotional, triumphant "Welcome Home" for the Bulldogs following the 2007 national championship win as Wilsonians lined the streets from the city limits to Wilson […]
Learn More! →Former Barton College basketball All-American Anthony "Ant" Atkinson and his Harlem Globetrotter teammates are featured in a seven-page article in the March 30 issue of Sports Illustrated.
Atkinson, who led Barton College to the 2007 NCAA D-II National Championship exactly two years ago, has already had his status elevated to the "Magic Circle" […]
Learn More! →


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Information in other languages |
| Private screeningTaking up offers of private health screening, outside of the NHS, is becoming increasingly popular as people seek assurance that they are not suffering from a serious health problem and as more companies advertise the private screening services that they provide. The UK NSC's advice on this issue for GPs can be found below. A guide for the public in England is also available. Both these publications were updated in November 2014. You can also view information comparing NHS screening to what is commonly offered privately. |


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Powerade ION4 Cherry Flavour 4 x 500ml
Product Description
Powerade Ion4 is a sports drink that…
Registered Informed Sport Product
Contains sugars and sweeteners
Has no added preservatives
Powerade is a great-tasting sports drink helping you to refuel and rehydrate better than water *.
Serve cold for maximum refreshment.
Keep one cold in the fridge
Please recycle.
Powerade Ion4 is a product of The Coca-Cola Company.
*When you exercise long and hard, Powerade Ion4 has not only water but also minerals and taste for effective hydration plus carbohydrates for performance.
Coca-Cola and the Environment
Coca-Cola is committed to making a positive difference - to the health of the planet, consumers and the communities it serves. The company is working hard to reduce its impact on the environment in everything it does - growing more while using less in areas such as energy and water use, waste reduction and recycling - and by encouraging people to think more about the positive impact they can have on their local environment.
Product Information
- Brands: Powerade
Store in a cool dry place. Refrigerate after opening and consume within 3 days.
Preparation and Usage
Best served chilled
Country of Origin
Produce of the EU
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Package Type
Shrink Wrapped
Allergy Advice: For allergens see highlighted ingredients
Water, Glucose, Fructose, Citric Acid, Mineral Salts (Sodium Chloride, Magnesium Chloride, Calcium Chloride, Potassium Phosphate), Fruit and Vegetable Concentrates (Chokeberry, Elderberry, Sweet Purple Potato, Safflower, Radish), Acidity Regulator (Potassium Citrate), Flavourings, Stabilisers (Acacia Gum, Glycerol Esters of Wood Rosins), Sweeteners (Sucralose, Acesulfame K), Antifoaming Agent (Dimethyl Polysiloxane)
Nutritional Data
Typical Values | Per: 100ml | Per: 250ml (%*) |
Energy: | 71kJ/ | 178kJ/ |
17kcal | 43kcal (2%) | |
Fat: | 0g | 0g (0%) |
of which saturates: | 0g | 0g (0%) |
Carbohydrate: | 3.9g | 9.8g (4%) |
of which sugars: | 3.9g | 9.8g (11%) |
Protein: | 0g | 0g (0%) |
Salt: | 0.13g | 0.33g (5%) |
Other Added Nutrients | ||
Sodium: | 50g | |
Potassium: | 12.5mg | |
Calcium: | 1.3mg | |
Magnesium: | 0.6mg | |
*Reference intake of an average adult (8400kJ/2000kcal) |
Customer Reviews
02 November 2013
All taste very much the same.
Unless my taste beds have gone on holiday every time I drink this drink. all the different flavours taste very much the same or a very brief noticeable difference.
27 January 2013
I agree with another reviewer. This or the blue one, both flavours are nice. AND this is now a better recovery drink than the competition, because it doesn't have sucrose, which is not a 'good' sugar. The Glucose and Fructose are better.
21 February 2012
This or the blue one!!
I switch between all the different powerade colours- each tastes nice and does the job well!
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Carnelian (nat.) Stick Drops 4-8x12-18mm
16" strand | $5.70 | OUT OF STOCK |
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Google to take on Apple TV with $299 'Nexus Q'
Google on Wednesday unveiled a new $299 hardware device called the "Nexus Q" that allows users to stream music, movies and music from the Google Play storefront.Like the $99 Apple TV, Google's Nexus Q will allow users to connect their mobile devices to an HDTV or entertainment center. Content available on an Android phone or tablet, including YouTube, can be streamed to the Nexus Q.
The sphere-shaped Nexus Q can be connected to an HDTV, a sound system, or even just a set of speakers. Google has dubbed the device as the "first social streaming media player," as it allows users to create collaborative music queues with friends adding their own songs to a playlist.
The Nexus Q runs on Android 4.0 Ice Cream Sandwich and is powered by a dual-core OMAP 4460 processor. It features 16 gigabytes of built-in storage and will be available in mid-July for $299.
In addition to connecting to external devices, it also features a built-in 25-watt amp that allows the Nexus Q to power speakers without a separate A/V receiver. It also has an optical audio port and Ethernet jack; Wi-Fi, Bluetooth and NFC support; and HDMI output along with an included HDMI cable.
The Nexus Q will support content from Google-centric applications including Google Play Music, Google Play Movies, Google Play TV, and YouTube.
The media streaming device is different from the Android-based Google TV platform that the search giant launched as an Apple TV competitor in 2010. But Google TV, which has been found on hardware built by third-party developers, offers features like Web browsing and installable applications, while the Nexus Q is portrayed as a device that integrates tightly with Google Play content and nearby Android mobile devices.
On Topic: Apple TV
- Apple in talks to become launch partner for cable-free HBO Now service
- Nvidia to take on Apple TV with Shield set-top box featuring Android TV
- Apple partner Imagination unveils PowerVR 'super-GPU' with 512 ALU cores for game consoles
- Piper Jaffray sees a revamped Apple TV set-top box being core of Apple's fall 2015 products
- Apple restarts talks with content owners for over-the-top, web-based TV service


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- Your file is being downloaded. It will remain available for download from the "My Files" section of your member area for 72 hours.
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Portrait of a beautiful woman looking up
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Author | TijanaSee portfolio |
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Country | Serbia |
Descriptive Category | People In Studio Woman |
Conceptual | Welfare Beauty European Beauty |
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["adult","beautiful","beauty","blue","care","character","close up","complexion","cosmetics","cute","face","fairy tale","fashion","female","fun","girl","hair","head","isolated","isolated on white","isolated on white background","looking up","make up","modern","people","perfect","person","pin up","portrait","princess","red","romantic","sensual","sitting","skin","skin care","smile","style","sweet","teen","teenager","trendy","valentines day","white","woman","young"]
adult beautiful beauty blue care character close up complexion cosmetics cute face fairy tale fashion female fun girl hair head isolated isolated on white isolated on white background looking up make up modern people perfect person pin up portrait princess red romantic sensual sitting skin skin care smile style sweet teen teenager trendy valentines day white woman young
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Available in JPEG format, this photo may be downloaded for all kinds of professional uses and in different resolutions (up to 6,000 x 3,996 pixels in 300 DPI).
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Description: Designed by Violet Craft for Michael Miller, this cotton print is perfect for quilting, apparel and home décor accents. Colors include white and black.
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Description: Designed for Michael Miller Fabrics, this vintage inspired cotton print features an allover design of cheerful white and black cups and saucers on a red background.
Description: Designed by Sarah Jane for Michael Miller Fabrics, this cotton print features an allover design of white 3/8" polka dots on a red background. Use for quilting and craft projects.


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Philosophy of Life and Death (Google eBook)This fascinating book of M.V. Kamath helps to answer the most crucial question of existence "What is the meaning of death?" Drawing from the wisdom of major religions and cultures of the East and West, he presents a clear, highly, informative study on the experience of Life and Death. Included are the thoughts and reflections of 55 famous men and women during their experience of dying, who tells us what we ought to know or intuite, that those who are well integrated die bravely, calmly and at peace with themselves. To mention a few names like Socrates, Madame Curie, Queen Elizabeth, Swami Vivekananda – these are people whose deaths tell us how to die. |
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User Review - Flag as inappropriate
The point of author is not direct, just sluggish.
15 | |
Life Death and the Question of Rebirth | 32 |
The Way of the Buddha and the Order of the Universe | 45 |
Reincarnation and the Life Eternal | 60 |
Death and the Nature of the Soul | 74 |
Judaism and the Doctrine of Free Will | 87 |
Islamic Concepts of Heaven and Hell | 100 |
The Doctrine of Justification by Faith Alone | 114 |
Albert Einstein | 189 |
Leo Tolstoy | 202 |
Muhammad | 216 |
Oliver Wendell Holmes | 230 |
Pope John XXIII | 245 |
George Gordon Byron | 258 |
H G Wells | 272 |
George Washington | 287 |
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accept action Akbar answer asked attain Aurangzeb believe birth body born Brahman breath Buddha Byron called Christ Christian consciousness dead death desire devachan died divine doctors dying earth eternal evil existence eyes faith final friends Gita God's Gogol grace hand heard heaven Hitler human Ibid immortality Ishopanishad Islam Jacques Monod Jainism Jesus jiva karma Keats King knew knowledge Koran kosha Krishna later live Lord M.V. Kamath Maimonides man's manomaya kosha maya means mind moksha mortal Mozart Nachiketa Napoleon nature Ndola Nelson night nirvana once pain peace person philosophy prayer question rebirth reincarnation religion replied returned salvation Satprem Satyavan Savitri seemed sense Socrates soul spirit Sri Aurobindo Stalin suffering Swami Tanguts things Thoreau thou thought tion told took truth universe Upanishad Vivekananda wanted wife words wrote Yama York Yudhishtira Zoroastrianism