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Cornell and Diehl
The Latest
About Us
About Our Tobaccos
Cornell & Diehl Past & Future
So long, 2014. It's been an incredible year. Although we've seen remarkable changes over the past twelve months, from improved production methods to upgraded technology, the truly exciting part came as a result: fantastic new blends and ...
Introducing Sixpence
From Chelsea Morning to Gaslight, the tobaccos of G.L. Pease's Old London series have been instant favorites, created the "old" way using traditional methods and techniques. Well, you might want to leave a little extra room in your ...
Introducing the Cellar Series
"Hmmmmm..." is always a major player in our vocabulary. It can range from a thoughtful intonation announcing the arrival of a "light bulb" idea for a new mix, to the harbinger of a groundbreaking compilation, one whose specific focus is to ...
Our Tobaccos
Smoking Basics
© Laudisi Enterprises, Inc. All rights reserved.
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know about special offers, sales,
the latest arrivals and much more!
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Say "farewell" to the frost and "hello" to sunnier days in the light and lovely layers of the Chills and Frills Peach Lace Dress! Frame your favorite necklaces with a lacy scoop-neck tank bodice that dips extra low at back. Flared skirt has Dotted Swiss godets for extra fullness. Elastic waistband. Fully lined and sheer. Model is wearing a size small. 50% Cotton, 45% Polyester, 5% Spandex. Hand Wash Cold. Imported.
NEED HELP CHOOSING A SIZE? See measurements & fit info for this garment in the Size & Fit dropdown!
PRODUCT MEASUREMENTS: Compare these measurements to your own body measurements. We measure each item "relaxed" on a flat surface, not stretched on a person's body. It is helpful to consider the material of the item, as some stretchy materials may give an inch or two.
Size | Bust | Waist | Hip | Length |
Small: | 26" | 20" | 28" | 31" |
Medium: | 28" | 22" | 30" | 31.5" |
Large: | 30" | 24" | 32" | 32" |
Because sizing and cut will vary between brands, please use this information as a general guide. Use our Size Chart to help determine your size. If you are between sizes or need help finding the proper size, please Chat with a Stylist.
Write a review and tell others what you think! As a part of the LuLu*s community, you can help others make great fashion choices!

subset: commoncrawl


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Milking My Big Clitty
Close & Play
Showing 1 to 1 of 1 comments.
- 1
Teddybellows - 1 year ago
I see a wedding ring. Why don't you put your cum in wife's pussy, rather than on nighty, and eating it? Does she approve of your crossdressing?
- 1


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Traffic Stop Nets Huge Shipment of Synthetic Marijuana
North Texas traffic stop results in major K2 bust
North Texas traffic stop results in major K2 bust
Police arrested and charged a woman for felony driving under the influence in upstate New York near Rochester last week.
No big deal, right? Well, this wasn't your typical DUI.
Here's a good reason to finally save the rainforest. If we destroy it, jaguars won't be able to get their fix anymore, and that could mean problems for everyone.
Remember kids, not everything in plastic bags is candy.
Do you think you're the biggest stoner around? We'll just have to see about that, won't we?
So, pack up your bowls, roll your joints, toke down and see how much of a stoner you truly are!
Walter White making meth in a camper is cool, being able to also serve some delicious Mexican food with your drugs is a whole new level.
If you're this guy, this has to be your eye-opener that you've finally hit rock bottom.
A North Carolina man was arrested over the summer after selling an undercover cop cocaine. But after the illegal substance was taken to the lab and inspected, they discovered it was not cocaine at all. The guy had sold the undercover cop a piece of a Pop Tart, WITN-TV reported.
Seems like his ass had it out for him.
I guess someone was watching 'Breaking Bad' and thought it looked simple enough to try out.
Strippers just want me for my money? No, don't you lie to me like that.
Kids are always coming up with new ways to get high and other than sniffing your own poo, this may be the dumbest way to get high ever.


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Latest Cetuximab Stories
BELLEVUE, Wash., Feb. 25 /PRNewswire/ -- Light Sciences Oncology, Inc. (LSO) today announced the achievement of a major milestone in its late-stage clinical development of Aptocine(TM) (talaporfin sodium) for treatment of solid tumors.
VENLO, The Netherlands, February 8 /PRNewswire-FirstCall/ -- QIAGEN (NASDAQ: QGEN; Frankfurt Prime Standard: QIA) today announced that its wholly owned subsidiary DxS has acquired the global and exclusive licence for biomarker PI3K from Johns Hopkins University to develop real-time-PCR and endpoint PCR assays.
Phase 3 X-PECT Trial (Xeloda(R) + Perifosine Evaluation in Colorectal cancer Treatment) to be led by Dr. Johanna Bendell, Director, GI Oncology Research, Sarah Cannon Research Institute QUEBEC CITY, Feb. 3 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.
NEW YORK, Feb. 3 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) announced today that it has reached agreement with the U.S.
Data Reported at the 2010 ASCO GI Cancers Symposium Demonstrate a Statistically Significant Improvement in Both Time to Tumor Progression and Overall Survival in the Perifosine + Capecitabine Arm Versus Placebo + Capecitabine Arm QUEBEC CITY, Jan. 25 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.
SAN ANTONIO, Jan. 21 /PRNewswire/ -- BioNumerik Pharmaceuticals, Inc. ("BioNumerik") today announced the treatment of the first patients in a global multi-center Phase III clinical trial of Tavocept (BNP7787) in patients with primary adenocarcinoma of the lung, the most common type of lung cancer.
Professor Dr. Sanford Markowitz details promising findings leading to reducing the burden of the disease.
- In medieval musical notation, a sign or neume denoting a shake or trill.


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Pooler The Coast
Pooler is a beautiful community just west of Savannah. Famous for the Mighty 8th Air Force Museum, it also offers outdoor activities at Tom Triplett Community Park. It is the site of Lock #3 of the Savannah/Ogeechee Canal System that dates to pre-Civil War times. Still visible today, are remains of the gatekeeper's house and 142 Civil War tent Mounds from Sherman's Army.The park is the perfect place to enjoy the great outdoors. Enjoy a stroll, jog or bike ride around the massive lake on a paved and lighted path. Test your skills one of the region's largest disc torment courts or take a peaceful kayak ride down the park's clean, long, deep & winding lake. Regular festivals and community activities keep this park a Pooler favorite throughout the year. The Mighty Eighth Air Force Museum preserves for all Americans the stories of courage, character and patriotism displayed by the men and women of the Eighth Air Force from World War II to the present.
Visitor Information Center
Pooler City Hall 100 SW Highway 80
Pooler, GA 31322
Phone: 912-748-7261
Official Visitor Information
Free Georgia Travel Guide
The state's official Travel Guide is your complete resource to planning a vacation in Georgia. Find trip ideas, attractions, events, activities, accommodations, maps, travel resources and much more.
Website: http://www.exploregeorgia.org
Phone: 1-800-VISIT GA (847-4842)
Oglethorpe Speedway Park
200 Jesup RoadView on Map
912-964-8200Oglethorpe Speedway Park (OSP) entertains thousands of auto racing fans every weekend March through October. OSP has been providing exciting racing action since 1951... Find Out More -
Ogeechee River Canoe & Kayak Rentals
318 Dublin RoadView on Map
912-964-0202Please call for reservations: Open March to October daily and November to February by reservation. Amenities/services: canoe rental, raft rental, kayak rental, tube... Find Out More -
National Museum of the Mighty Eighth Air Force
175 Bourne AveView on Map
912-748-8888Visit one of the world's most powerful museum experiences, the National Museum of the Mighty Eighth Air Force. Located only minutes from historic downtown Savannah... Find Out More -
Royal Cinemas & IMAX
5 Towne Center CtView on Map
912-988-0911Royal Cinemas is proud to present a contemporary, modern theatre on the Georgia Coast. We are the only locally owned and operated theatre in the area. We have extensive... Find Out More
Quality Inn - Pooler
125 Bourne Ave.View on Map
912-748-0017Just 15 miles west of Savannah on I-95, the Quality Inn® in Pooler offers easy access to several large companies, including Gulf Stream, Flight Safety, Mitsubishi Power... Find Out More -
Holiday Inn & Suites - Savannah Airport - Pooler
103 San DrView on Map
912-330-5100The Holiday Inn & Suites Savannah Airport – Pooler, is an award winning property that is conveniently located two miles from the Savannah – Hilton Head International... Find Out More -
Travelodge Suites - Pooler
130 Continental Blvd.View on Map
912-748-6363Suites with Jacuzzis. Two-room suites available. Heated indoor pool. Phone with data ports, Free continental breakfast. Cable with HBO. Group rates. Find Out More -
Red Roof Inn & Suites - Pooler
20 Mill Creek CircleView on Map
912-748-4050Outdoor heated poo, hadicap accessible, meeting facilities for up to 40 people, continental breakfast, airport shuttle. AARP/AAA Discounts Find Out More
The dining information on this page is supplied by the Georgia Restaurant Association.


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Featured Authors: Miller Caldwell, iSage Sweetwater, iElizabeth Parker, iRobin Leigh Miller, iScott Boyd, idawn kunda, iTina Tessina, i |
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This year's City of Hope Spirit of Life Award honoree was OPI's George Schaeffer. At a party in his honor this past Saturday night, more than 1,700 guests were treated to the soulful stylings of Reverend Al Green and Aretha Franklin. And true to Schaeffer's gift for surprise, we all also got to see him marry his long-time girlfriend Irina Afzal.
The annual beauty industry Spirit of Life Award is a tradition at the summer Cosmoprof North America Show, and as its honoree this year, Schaeffer committed to breaking all industry records with the amount of money raised. Schaeffer vowed to match dollar for dollar everything raised up to $2.5 million, and, sure enough, through efforts that included a special City of Hope limited lacquer collection, a raffle for an Audi A7, a hard-cover tribute book with hand-drawn illustrations by City of Hope patients, and countless other fund-raising efforts undertaken in Schaeffer's name, more than $2.7 million was raised.
The evening's entertainment were two separate concerts, one by Al Green and one by Aretha Franklin. It was a rocking fun evening. Everyone danced and sang along. We had the entire NAILS crew there (including Ed Bobit, our founder, and Ty Bobit, our president) to enjoy and celebrate Schaeffer's great accomplishment.
But, as many of you who've followed Schaeffer's illustrious career over the years know, he's always got a little something extra up his sleeve. So after a meal conceived and prepared by Hubert Keller (you might recognize that name from the "Top Chef" series on Bravo), the presentation of the award, a live in-person vocal accompaniment to a tribute video by Five for Fighting's John Ondrasik, and a $5.2 million donation to the City of Hope for diabetes research, George married his long-time girlfriend Irina Afzal. (Turns out, George actually got married officially last year, on 11/11/11 at 11:11 but this was the public celebration that he wanted to share with industry friends.)
Since most of our readers were not there to enjoy the evening with us, we hope you'll enjoy the photos of some of the evening's highlights.
You can also click here to watch the tribute video of George we got to see at the party.
Keywords: charity George Schaeffer OPI products Star Nail Products Tony Cuccio
Hidden Gems: Underside Nail Art 11 Photos
Nail Looks From NYFW F/W2015 188 Photos
Fanicure: Super Bowl-Inspired Nails 51 Photos
NAILS Next Top Nail Artist: Season 2 Finale Party 60 Photos
Hidden Gems: Underside Nail Art11 photos
Nail Looks From NYFW F/W2015188 photos
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text:
Dead Rising 2
Question from uncensord
Cold case and sidemissions?
If i dont complete the case files can i still save most all the surivors?
4 years ago
xanrus answered:
4 years ago
POWNAGELINK57 answered:
Yes, you just get the worst ending possible.
4 years ago
mrstilwater answered:
You cant get Hidden Combo cards or get Queens, even through Nectar... its worth playing the story if you haven't unlocked all the Hidden cards and such...
4 years ago
This question is open with pending answers, but none have been accepted yet
Answer this Question
You must be logged in to answer questions. Please use the login form at the top of this page.
More Questions from This Game
Question | Status | From |
Case 4-1 help? | Open | lishowron |
Case 6-4 Help? | Answered | ja1234ke |
Why do I keep getting so little time on Case 6-4? | Answered | Pokejedservo |
Why does jared die in case 5-1 for no reason? | Answered | jimmybono |
Does your money carry over from Case Zero? | Answered | bastrdblade77 |


text:
Cuthbert Larking
18 of 31 portraits on display in the Billiard Room at Bodelwyddan Castle
Cuthbert Larking
by Carlo Pellegrini
watercolour, published in Vanity Fair 11 August 1888
12 1/4 in. x 7 1/8 in. (311 mm x 181 mm)
Purchased, 1970
Primary Collection
Click on the links below to find out more:
Artistback to top
- Carlo Pellegrini (1839-1889), 'Ape'; caricaturist. Artist associated with 478 portraits, Sitter in 5 portraits.
Linked publicationsback to top
- Saywell, David; Simon, Jacob, Complete Illustrated Catalogue, 2004, p. 365
Exhibitions and displays
- Thomas Carlyle: Historian of Heroes
Until 30 March
Related pages
See this portrait
On display in the Billiard Room at Bodelwyddan Castle


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Welcome to UKLet.co – Your Local Letting Agent!
To let London
We are the only agency in Central London who is able to help clients looking for studios, bedsits, flat-shares or luxury houses / apartments for short or long term in all Central London areas.
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Bed and Breakfastfrom £25 per night |
Also if you looking for that little extra comfort in life why not go to our Luxury Lets.


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Mustache Goatee Devil Set Blac A simple mustache can change your looks and personality. Morris has the widest selection of mustaches and goatees available. Each facial hair item or set includes self adhesive tape strip or can be applied with spirit gum or latex (not included). Each is contained in a blister pack with color back card.
our price: $ 12.95 OUT OF STOCK
Shield Roman,Gold
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Spirit Gum 1/8Oz & Remover 1Oz
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Warriors Arm Bands Pair
Beard Full Grey
Deluxe Predator Hands
Wig Gothic Vamp
Wizard Good 2 Mask


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I'm writing a .bat script where I need to copy a file to System32. I change to the folder then attempt to copy the file from a storage folder to the System32 folder.
cd C:\Windows\System32
copy %~dp0file.txt file.txt
I get an error Access Denied, 0 files copied
I see why this is a problem, because if I try to copy a file to System32 using the non-programmatic GUI interface, I get a prompt asking me to confirm. So with the script, how do I bypass this Windows permissions or set it correctly, or some other solution.
Edit: The hint I got from the answer below is that it's possible to trigger Windows to show its GUI prompt for the user to give permissions. This idea will do. Hopefully someone knows exactly how to do this.


text:
Hotel Czardasz is placed on suburb of Plock city. Hotel Czardasz is located on the outskirts of the city of... More Info »
Starzynski Spa and Wellness Hotel is located in the heart of the Plock Old Town. It features spacious rooms with free... More Info »
Video guides, travel podcasts, city maps & free city guides. What to eat, where to stay and things to do and see - our travel guides have it all.
Find a guide »We offer the most comprehensive selection of hostels on the internet with over 35,000 great places to stay in 180 countries. The ultimate online resource for hostels everywhere.
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(also botanical garden)
Definition of botanic garden in English:
An establishment where plants are grown for scientific study and display to the public.
Example sentences
- However, in a few cases, seeds of plants cultivated in botanical gardens were also used.
- Visit native plant nurseries and local botanical gardens and arboreta to learn which ones best fit your site.
- There's a botanical garden with carnivorous plants on display.
Definition of botanic garden in:
- US English dictionary
What do you find interesting about this word or phrase?
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Dickinson High, NDSU grad interns for Sen. Heidi Heitkamp in Dickinson
When Dickinson High School graduate Michael Steve isn't coaching a Babe Ruth baseball team this summer, he is interning in Sen. Heidi Heitkamp's Dickinson office.
"Being able to understand how all these laws work and are made and how the cities and states cooperate with each other is kind of interesting," said Steve, a 2013 North Dakota State University graduate.
Get the full story
Subscribe or Log In
Are you a newspaper subscriber but you don't have a Digital Access account yet? Activate your account.
You will need your subscription account number and phone number. Not sure if you have an account? Call (701) 225-8111 and we can help you.


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Sweater: similar
Top: similar
Jeans: Macy's
Bag: similar
Necklace: similar
Heels: similar
Love your outfit. Gorgeous and I don't think you look like a first grader, maybe a second grader :) I love polka dots. You can't have too many in your closet.
Haha! Those polka dot pants are so cute and I love the pop of mint!
The Tiny Heart
JCrew Giveaway!
You are so funny, Kacie! That would definitely make one very stylish first grader ;)
xo, alison*elle
lovely outfit! polka dot pants are the best!
You're so pretty! Love the overall outfit, and the clutch and purple sweater are my favorites :)
Haha, this was a funny morning read! I love the colors and the polka dots in this outfit!
The Weekend Diary
Lol I love everything about this post. You'd make one very stylish first grader. I love the mint and purple combo. It's a more stylish take on Barney, haha. And your polka dot pants are so adorable, and so wearable. Love it all!
Absolutely Love this look! The colors, dots, bag... All great! :)
XO Nat
Nat in Love
OMGosh can this look just appear in our closets! love everything.
you look awesome!
xo. c & v
cake & valley
heheh this is so cute :) definitely going to dress like a 1st grader one day soon!
Mili from call me, Maeby
You forgot to braid your hair for the full effect! BTW, share some of your long legs with everyone else, okay?
ReplyDeleteThe color of this sweater is gorgeous, and I love it combo'd with the polka dot pants. So pretty!
The Glossy Life
If I only I had actually dressed like this as a 1st grader, looking at old photos wouldn't be so embarrassing :) I love the polka dots and the color combo!
Sarah's Real Life (Bead for Life giveaway in progress…)
ummm you are tooo cute!!!
Sandy a la Mode
Polka never fail. Love 'em with the cable knit sweater.
Flounces and Hubbub
I LOVE this! You're making me want to dress like a first grader...so cute Kacie :)
The Other Side of Gray
I love this outfit! Maybe that means that I like dressing like a first grader (it probably does). I actually just posted an outfit a lot like this on my blog. By the way, I am your newest follower on GFC! :)
-Mary @ Style That Moves
This probably sounds really weird, but I just made a SIMs character with this exact same outfit! Love it!
Kate @ A Journey in Style
Just discovered your blog from The Other Side of Gray and I love it! Really like your style!
A Song to Pass the Time


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Straits of Mackinac near Mackinac Island, MI
The following tours drive by Straits of Mackinac:
4/21/2015 - 11/2/2015
Whether you use your round trip on the Star Line Hydro-Jet Ferry to cross from St Ignace to Mackinac Island and back again, or simply take a ride to enjoy the sights of Lake Michigan, the Hydro-Jet Ferry is both functional and entertaining!
We also offer a detail of most tour stops, drive bys and visits with our Tour Connections page.
The Straits of Mackinac a major shipping lane providing passage for raw materials and finished goods. Before the railroads reached Chicago from the east, most immigrants arrived in the Midwest and Great Plains by ships on the Great Lakes.
The straits is five miles wide at its narrowest point, where it is spanned by the Mackinac Bridge. Before the bridge was built, car ferries transported vehicles across the straits. Today passenger-only ferries carry people to Mackinac Island, which does not permit cars. Visitors can take their vehicles on a car ferry to Bois Blanc Island.
Islands in the Straits of Mackinac include the two populated islands, Bois Blanc and Mackinac, and two that are uninhabited: Round and St. Helena islands. At 11 miles in length, Bois Blanc is the largest island in the Straits.
The straits are shallow and narrow enough to freeze over in the winter. Navigation is ensured for year-round shipping to the Lower Great Lakes by the use of icebreakers.


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Balenciaga brings a modern twist to the classic square-shaped sunglasses. The Balenciaga BAL143S 807 Black Oversized Sunglasses are fashioned with a solid and durable acetate frame with a super high-gloss finish. The lenses are a Grey Gradient that provides 100% protection from the sun's harmful UVA rays. Oh, you can only wear prescription lenses? No worries, because these square shaped sunglasses are available for those who require prescriptions. Each arm is gold metal-embossed with the ...
Ryders Cadence R383 005 Gold sunglasses are versatile and comfortable. This squared aviator style comes with anti-slip temple tips and adjustable nose pads. The gold metal frame is complemented by classic solid green lenses.
For high-end contemporary brand eyewear, try Alexander McQueen Aviator Sunglasses AMQ4195S BG4 N3. Alexander McQueen sunglasses are renowned for their impeccable craftsmanship and design integrity. Constantly inspired by nature, Alexander McQueen sunglasses often create juxtapositions of fragility and strength and tradition and modernity. With a variety of unique and cutting edge designs that establish beauty and style in the most innovative of ways, the Alexander McQueen brand is always on ...
Marc Jacobs MJ409S XH4 JD Honey Havana 57 sunglasses are indulgently glamorous. The oversized square shaped frame has a semi-transparent havana upper and crystal honey bottom rim with large rounded lenses. The tortoise temples are enhanced by the subtle touch of light gold from the hinges and Marc Jacobs branding.
Yves Saint Laurent YSL6347S E4S PT Black Grey Striped 58 sunglasses are a squared off cateye style. The oversized lenses are contrasted by the thin feminine temples, soft grey gradient lens and a black to grey ombre frame front. In true Saint Laurent style the temples are minimally accented with gold hinges engraved with the YSL logo.
Yves Saint Laurent YSL6347S 807 70 Black 58 sunglasses are a squared off cateye style. This oversized frame features thin feminine temples, solid grey lenses and a shiny black finish. In true Saint Laurent style the temples are minimally accented with gold hinges engraved with the YSL logo.
Yves Saint Laurent YSL2331S YXH HD Black 57 sunglasses are a modern square wayfarer style. This oversized frame is dramatic and refined. The shiny black frame features gold hinges that have been engraved with the Yves Saint Laurent logo. This detail is followed by a matte rubberized temple segment that is classy, sophisticated and right on trend.


text:
Monies Gardai receive for policing One Direction concerts and others shoots up in 2014
- Music
- December 22, 2014, 01:00
New figures show that in spite of missing out on a bonanza from policing the cancelled Garth Brooks concerts, the monies the Garda Síochána has recei(...)
Munich debate over plaques for Holocaust victims continues
- Europe
- December 5, 2014, 01:00
When 91-year-old Peter Jordan returned this week to Munich it was in spite of, and because of, his past.He was just 15 when, in the summer of 1939, he(...)
Germany's foreign-nationals give more than they take, says report
- Europe
- November 29, 2014, 01:00
Foreign-nationals living in Germany are a boost, not a burden, to the country's welfare system, according to a new survey.The 6.6 million people livi(...)
Samir Nasri: We need to win or be sold
- Soccer
- November 25, 2014, 12:14
Samir Nasri accepts he and his Manchester City team-mates must deliver in the Champions League — or face the axe. City have again failed to imp(...)
Martin Demichelis believes Bayern Munich won't hold back
- English Soccer
- November 24, 2014, 11:10
As a former Bayern Munich player, Martin Demichelis knows the challenge Manchester City face when Pep Guardiola's team take to the Etihad Stadium pit(...)
Nazi past lingers ambiguously in culture of Bavarian capital
- Europe
- November 24, 2014, 01:00
In Bavaria, the Nazi past is seeping up again through the cracks in its historical floorboards.At a Monday press conference, the world will learn the (...)
Get yourself to a Christmas market
- Travel
- November 22, 2014, 14:15
What: Continental Christmas Market Where: Galway When: November 21st – December 22nd It's only been going five years and yet it is Irel(...)
Bayern Munich fightback denies Dortmund
- Champions League
- November 1, 2014, 21:17
A late Arjen Robben penalty gave Bayern Munich a dramatic 2-1 comeback win on Saturday that sent Borussia Dortmund sliding into the drop zone after(...)
Inside German football: True love drives Dortmund devotees
- International
- October 11, 2014, 06:00
Once you've been to a certain number of football stadiums they begin to blur into each other, but something about the Westfalenstadion in Dortmund bre(...)
Maybe the best Manchester City can hope for is to avoid defeat
- Champions League
- September 16, 2014, 23:15
The mission for Manchester City in Bavaria this evening is to prove their Champions League lesson has been learned. With Manuel Pellegrini hoping for(...)


text:
Hepatitis C And Treatment
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
TRANSMISSION OF HEPATITIS C AFTER TREATMENTI HAVE A FRIEND WHO WAS TREATED FOR HEPATIS C 4 YEARS AGO AND ALL RECENT BLOODWORK SHOW NO SIGNS OF THE DISEASE.IS HE STILL A CARRIER AND CAN HE STILL TRANSMITT THE DIESEAS SEXUALLY?Response from Barbara McGovern, M.D.
Tufts University School of Medicine
...Treatment can cure hepatitis C. It is great news that he has such a wonderful result from treatment.I would still have safe sex if this friend is your sexual
Read more »
Mental Side effects of Hepatitis C treatmentPlease could you give me information relating to the mental deterioration I have been warned to... Read more »Hepatitis C Treatment Side Effects Heat EarsCurrently on Ribiviran and Interferon for HepC. Have hot spot on my leg. Is this a side effect,... Read more »
Hepatitis C Treatment and Management... Hepatitis C treatment: how, why, when Who needs treatment? How is hepatitis C treated? What is pegylated interferon? How long Read more »Clinical Manual: Hepatitis C Treatment... Therapy After Therapy References This document was designed to give providers practical information about anti-hepatitis C treatment. It includes links to other related electronic documents on this site, as well as the Patient... Read more »FDA Approves Hepatitis C Treatment Ribasphere... The Food and Drug Administration has approved the hepatitis C treatment Ribasphere, co-manufactured by Par Pharmaceutical Cos. and Three Rivers Pharmaceuticals LLC, the companies said Monday. Read more »Hepatitis C Treatment May Halve Injections...Early research indicates that Human Genome Sciences' experimental hepatitis C treatment, Albuferon-alpha, may require fewer doses and stay in the bloodstream longer than the treatments of its major competitors, Read more »
Connect With Others
Hepatitis C
Posted by saylomoon, 1 Reply
...Hola amigos, como sabran tuve una posible exposicion con agujas mi pregunta, si alguien sabe, el periodo ventana para hepatitis C, hasta cuantos anos o meses se amplia, ya que en unas paginas lei que eran 6 meses y en otras son 3 anos. tengo...
Read more »
Hepatitis C
Posted by hopefulindy, 1 Reply
I tested HIV- at 3.5 months post possible exposure. I have on going health issues and no answers. I am waiting on blood work to see if I have been exposed to Hep C. If someone is infected with Hep c and HIV at the same time would that slow the...
Read more »
Hepatitis C
Posted by capeac, 1 Reply
...no tengo de nuevo hora para la consulta y me gustara saber que sabeis sobre la fiabilidad de los resultados en el test de la Hepatitis C. ?Es cierto que cabe la posibilidad de un falso negativo -ojo estoy hablando de la Hepatitis C no del VIH-...
Read more »
Periodo en caso de coinfeccion con la hepatitis c?
Posted by Anonymous, 1 Reply
Alguien me podria decir si con 6 meses seria suficiente?
Read more »
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PlantFiles: Variegated Beach Spider Lily
Hymenocallis littoralis 'Variegata'
Family: Amaryllidaceae (am-uh-ril-id-AY-see-ee) (Info) Genus: Hymenocallis (hy-men-oh-KAL-is) (Info) Species: littoralis (lit-tor-AY-liss) (Info) Cultivar: Variegata One vendor has this plant for sale. 4 members have or want this plant for trade. Category: Height: Spacing: Hardiness: Sun Exposure: Danger: Bloom Color: Bloom Time: Foliage: Other details: Soil pH requirements: Patent Information: Propagation Methods: Seed Collecting: | Click thumbnail to view: By nifty413 By turektaylor By vossner By eliasastro |
3 positives
No neutrals
No negatives
Gardeners' Notes:
This plant has been said to grow in the following regions:
Calistoga, California
Cape Coral, Florida
Pompano Beach, Florida
Louisville, Kentucky
Abbeville, Louisiana
Elizabeth City, North Carolina
Massillon, Ohio
Corpus Christi, Texas
Garland, Texas
Richmond, Texas


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Tesco Lotus Superstore: Fresh fish
Advertising Agency: BBDO, Bangkok, Thailand
Executive Creative Director: Suthisak Sucharittanonta
Creative Director: Subun Khow
Copywriters: Subun Khow, Chanatthapol Tiensri
Art Directors: Suthisak Sucharittanonta, Ariyawat Juntaratip
Photographer/Illustrator: Anuchai Sricharunputong
Account Supervisors: Methawin Udomwatchararatsamee, Nattaya Patthananont
7 comments
There are so many books out there called things like "Don't make me think" and "Press Me" etc etc explaining that people like to be curious but not think too much. This ad is actually good but skates that line very finely.
David Byrne
the chopping board looks like it will fall very easily. and to add more dangerous scenes, the knife is so gonna fall with it...
anyway, nice ad.
* it's not how good you are. it's how good you want it to be *
This is better executed. Althought the idea is quite literal, the well elaborated production makes it a great ad. Well done!


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Monthly Archives: November 2010
New arrival baby Grace
Congratulations to Steve Trish and family on the birth of their baby daughter Grace this afternoon best wishes from all South East Road club
Tony Breen off to Cork
Tony Breen is off to Cork at the end of the month for the weekend to part take in the first of the junior training sessions been organised by Dan Curtin and others incharge of the national developement squads. This is a stepping stone to hopefully make one the regional if not the Irish team.
The club would like to wish Tony well for the weekend and also he is one of the first riders in the club to avail of one to one coaching programme for our juniors. We hope he can build on last years performance and really show his true potential….
best of luck Tony…
I have been onto the Springhill hotel in Kilkenny, part of the Brennan Hotel group,and I have a date for a proposed trip away next Feb.
On Feb 12th (saturday)… I am planning a cycle from Arklow down to Gorey and over too Kilkenny through Ferns etc.. approx 110-120Km. I have a car sorted to carry luggage there and back. When we arrive we get soup/sambos and tea/coffee…. one evening meal, bed and full irish breakfast.. all for €77 each. This includes full use of the gym/pool and sauna…
Anybody interested please contact me on 087 0617615, e mail firstname.lastname@example.com.. I wanna get this closed off by Dec 19th.. so please pay up in full by then to secure a space…
Many thanks
Club AGM 2010
The SERC had its AGM on Friday night last and over 40 club members turned up. The meeting went off well and reviewed what was a great year for the club. There was some minor adjustments made to the committee, Derek Webb stood down as President but remained on as secretary. Popular club member Willy Murphy is the new club President, so all bow in his presence. Mick Considine left the PRO job for his new title as Youth Development officer. John Maguire is the new Max Clifford in the PRO job… James Forde and Ciaran Furlong stepped down as treasurer and assist treasurer. We thank them both for their excellent work for the past 2 years. Jaqi Gannon his the new person with the purse strings. After that there was not much change on the committee… however we are delighted to announce Derrick Evans as Club Captain.
The club has a busy calendar for 2011. It plans to run its normal Hamper race, the Conor Mc Cabe Memorial. Club Calendars will be on sale in the coming days… We have a bag packing day planned in a few weeks in Dunnes, The 3 Peak Challenge is been planned for April, a Youth 2 day in July, The Falling Leaves Classic in August.
The club are also looking at a fundraising ride from Malin head to Mizen head, the date has to be confirmed in the coming weeks.
The club is also in Feb 2011 rolling out Sprocket Rocket in schools across the South East. We are in talks with schools to put this in place for 2011 and signing up more schools on a weekly basis. More information on this in the coming weeks also.
The club is also launching 'Operation 3 Peak Challenge' this month and have already signed up 12 new club members in the past month who are part taking in this great challenge. Its not too late for anybody ready this to contact the club and get more info, as training doesn't start until Jan '11…
Apart from the regular club spins from Arklow at 9.40 from opposite Fern Hill saturdays and sundays. The Club also has a group leaving every sat and sun at 10am from the new bike shop Revolve… new riders are always welcome to come along….


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Prism for iOS is a new unique filter based editor for your photos
Prism (U.S. $2.99) takes a unique spin on applying photo filters. You load an image, and the app checks to see what colors make up your photo. It then displays a filter wheel, and as you move around the outer edge and explore the central parts of the wheel you will see a variety of effects. Some are subtle, others are pretty wacky. Of course, the ultimate filter selection is up to you. Prism also lets you engage the iPhone camera and snap away with filters applied.
There isn't a help menu, but you can view how it all works in an online video. I would put the app in the "you figure it out by exploring" category. There's nothing wrong with that, but some people might be frustrated. Even selecting photos isn't exactly standard. When you start, the latest item in your camera roll appears. You can swipe to the next one, or use the wheel to rapidly move in your library.
The app really is a clever way of applying filters, and you'll get a lot of ideas exploring the many permutations offered. Prism provides 14 color-based filter groups and 128 filters. Your images are saved at full resolution.
Prism is a great way to explore the possibilities in each photo you take. You'll have to invest some time learning how the app works, but with that investment comes the power to create some really expressive images.
Prism is not a universal app, so it's best for the iPhone or iPod touch. It requires iOS 7.0 or greater, and it's optimized for the iPhone 5.
Software Updates
more updates- Apple Remote Desktop updated with Yosemite support
- OS X Yosemite 10.10.2, iOS 8.1.3 updates now available
- Sports Illustrated 120 SPORTS channel comes to Apple TV
- Logic Pro X update brings AirDrop support, new effects, tools, and more
- Parallels Access 2.5 released, adds file manager, computer-to-computer remote access
- The Google Translate iOS app is about to get a lot smarter


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In the London Review of Books, Edward Luttwak starts his review of Britain against Napoleon: The Organisation of Victory, 1793-1815 by Roger Knight by contrasting British and European views of Napoleon's legacy:
I can recall few heated arguments with my father, but I remember very well our Napoleon quarrel. After two years at a British boarding school, I had learned a fair amount of English and just about enough history to mention Wellington and Waterloo as we were approaching Brussels on a drive from Milan. To my great surprise, my father burst out with a vehement attack on 'the English' for having selfishly destroyed Napoleon's empire. Wherever it had advanced in Europe, modernity had advanced with it, sweeping away myriad expressions of obscurantism and hereditary privilege, emancipating the Jews and all manner of serfs, allowing freedom of, and from, religion, and offering opportunities for advancement for the talented regardless of their origins. I do not recall his actual words, and he would hardly have put it as I have here, but that was certainly his meaning, and I remember his equal-opportunity quotation: 'Every French soldier carries a field-marshal's baton in his knapsack.' I also remember his explanation of the reason he accused the English of being 'selfish': Great Britain was already on its way to liberty and did not need Napoleon, but Europe did, and Britain took him away.
In other words, for Jozef Luttwak of Milano, formerly of Arad, Transylvania, as for many others on the Continent (and not only the French), all the wars of Napoleon, all his victories, counted for little in evaluating the man and his deeds. What counted was the progressive moderniser, the law-giver of the Code Napoléon of 1804, actually the Code civil des Français, which was really a civil code for Europeans, since Napoleon's empire français extended across the Low Countries to Jutland and into northwest Italy, and took in the ex-Papal States and Dalmatia (as Illyria), adding up to a good part of Western Europe. Nor was Napoleon's Code as ephemeral as his victories. It endures as the core of civil law not only in France but in its former European possessions, and their former possessions too, encompassing ex-French Africa, all of Latin America and the Philippines by way of Spain, and Indonesia by way of the Netherlands, as well as Quebec and Louisiana.
Even that list understates the influence of the code, and therefore of Napoleon the moderniser. Its text conveyed three powerfully innovative principles whose influence transcended by far its actual legal application, and which no restoration could undo: clarity, so that all could know their rights if they could read, without the recondite expertise of jurists steeped in customary law, with its hundreds of exemptions, privileges and eccentricities; secularism, which inter alia replaced parishes with municipalities, thereby introducing civil marriage, part of an entirely new form of individual and civic existence; and the right to individual ownership of property – which untied the immobilised holders of communal property – and employment free from servile obligations.
It mattered greatly that these revolutionary principles were proclaimed by Napoleon, already a conservative and commanding figure – unlike the revolutionaries of 1789, who could not give an aura of authority to their Declaration of the Rights of Man and of the Citizen, which was itself soon challenged by the more egalitarian 1793 version, with both anyhow rejected by the upholders of privilege. In Napoleon's vassal states (the Confederation of the Rhine, the Kingdoms of Spain, Italy and Naples, and the Grand Duchy of Warsaw), even where the code was not promulgated it was imitated, as was its drastically new style. Just as the florid convolutions and encrustations of rococo had been replaced by the linear elegance of the empire style, the thickets of customary law that Montesquieu had praised as barriers to despotism – as indeed they were, but only for privileged jurists – were replaced by the utterly systematic code, whose descending hierarchy of books, titles, chapters and sections that devolved into 2281 numbered paragraphs was itself infused with the new spirit of modernity. For Europeans of a liberal disposition, the code was a call to modernise not merely the law but society in its entirety – an impulse that would persist for decades.


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PAR Springer-Miller Awarded Two Bronze Stevie AwardsThursday September 26th, 2013 - 3:03PM M
| | | | | | | | | | | These are shortcuts to your favorite social networking and bookmark sites. Add this story to your Facebook page, del.icio.us, DiggIt, and many others!
NEW HARTFORD, NY—PAR Springer-Miller, a subsidiary of PAR Technology Corporation, has received two Bronze Stevie Awards for their ATRIO Guest Experience Management Software. The company was awarded in two separate categories: the Most Innovative Tech Company of the Year (Up to 2,500 Employees) and Tech Innovation of the Year (At Organizations With Up to 1,000 Employees) at The 11th Annual American Business Awards held on September 16 in San Francisco. The American Business Awards represent the nation's premier business awards program. All organizations operating in the U.S. may submit nominations—public and private, for-profit and non-profit, large and small. Nicknamed the Stevies for the Greek word for "crowned," winners received the trophies during a gala banquet on Monday, Sept. 16 at the Julia Morgan Ballroom in San Francisco. More than 250 nominees and their guests attended the event. More than 3,200 nominations from organizations of all sizes and from virtually every industry submitted nominations this year for consideration in a wide range of categories, including Most Innovative Company of the Year, Management Team of the Year, Best New Product or Service of the Year, Corporate Social Responsibility Program of the Year and Executive of the Year. PAR Springer-Miller and ATRIO received nominations for Moving Hospitality to the Cloud in both the Most Innovative Tech Company of the Year (up to 2,500 Employees category) and Tech Innovation of the Year (at Organizations With Up to 1,000 Employees) category. Tags: PAR Springer-Miller • Hospitality • Operational • |
The theme of this year's ALIS conference was "Don't Worry, Be Happy." But, lets face it, there are always going to be some people who aren't happy unless they are worried about something—whether it's the Fed potentially raising interest rates or that the price of oil is now too low, threatening to cripple the economies of some foreign nations.
Trump Toronto, Tesla Get Electric »
Marriott Reveals European Expansion Plans for Moxy
William Blackham Named CEO of Supertel Hospitality
Punderson Manor Lodge to Reopen After Major Renovation
New Ownership for The Setai Miami Beach
Centara Hotels & Resorts Acquires Third Vietnam Property


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Fireye InSight II Integrated Scanner: First Primary Safety Control To Receive UL SIL3 Functional Safety Certification
DERRY, N.H., Jan. 24, 2013 /PRNewswire/ -- The Fireye InSight II is the first Primary Safety Control to be certified by Underwriters Laboratories (UL), a leading global independent safety science company, to Safety Integrity Level 3 (SIL3), providing customers with assurance that its products meet a high level of safety. Fireye is a part of UTC Climate, Controls & Security, a unit of United Technologies Corp. (NYSE: UTX).
The InSight II scanners, currently installed in power plants and refineries around the world, offer a host of technical features applicable to industrial and utility fuel burners. The InSight II flame scanner determines a target flame from other flames or hot background that may be present in the combustion chamber. If the target flame goes out, the InSight II sends a signal to the burner management system to close that fuel valve to prevent unburned fuel from entering the boiler, eliminating the potential for an explosion.
UL SIL certification uses extensive safety research, scientific expertise and uncompromising focus on quality to evaluate a sample of the product and determine if it complies with the safety requirements of a published functional safety standard. The certification provides end users with a clear and trusted understanding of the safety around using the product in their overall systems.
For more information, please visit the Fireye website www.fireye.com.
About FireyeFireye is a leading manufacturer of flame safeguard controls and burner management systems for commercial and industrial applications throughout the world. Our products can be found in a variety of public buildings, commercial properties, power plants, pulp and paper mills, petrochemical facilities and food processing plants. Fireye is a part of UTC Climate, Controls & Security, a unit of United Technologies Corp. For information about Fireye, visit www.fireye.com. SOURCE FireyeCheck Out Our Best Services for Investors
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In Praise of Failure
At a time of new beginnings, novelist Adam Ross contemplates his past
by Adam Ross
January 3, 2012 "I write these words as a man with a Ph.D. in failure, and I commenced my subject's study on the day I decided to become a writer, a life-changing choice I made in 1986, after taking a creative-writing class my sophomore year at Vassar College. How many times did I fail? Let me count the ways." As the rest of the country makes resolutions for self-improvement, celebrated Nashville novelist Adam Ross considers the value of failure.
Published Monday, 5 January 2015
Oysters and Pop Tarts
A Chapter 16 writer tells a tale of two Christmases
by Maria Browning
December 19, 2014 When I was a child, Christmas at Granny Browning's house was about tradition, not pleasure. Christmas at home was an orgy of expensive presents and junk food. Both of them were wonderful and awful—and both were gifts to last a lifetime.
Published Friday, 19 December 2014
In launching a nonprofit literary center, a writer nurtures her own creative life in surprising ways
by Susannah Felts
December 18, 2014 Six women gathered around and bravely shared their writing, some for the first time. Their enthusiasm and laughter were contagious, their easy camaraderie a stroke of luck. Workshops don't always give rise to a circle of friends, but this one did. I could see that much. What I couldn't see yet was how it was also working as the start of something else.
Published Thursday, 18 December 2014
The Kite
A boy in a coal town finds his way out of the dust
by Pete Kopcsak
December 17, 2014 Mothers stopped peeling potatoes and scrubbing clothes to stand on bare porches and watch. We fell on the weeds in front of us and cupped our hands into imaginary telescopes and pressed them to our eyes to watch the kite as long as we could.
Published Wednesday, 17 December 2014
A Journey for Justice—and Understanding
A poet joins the NAACP march in Ferguson, Missouri, and learns he was wrong about the role of race in this country
by Andrew McFadyen-Ketchum
December 16, 2014 I've been asked more times than I can count why I marched with the NAACP. Friends wondered if I believe Michael Brown was really innocent. Marchers wondered why a white poet from Denver would make such a journey. There's no simple answer to either question.
Published Tuesday, 16 December 2014
Victoria's (Best-Kept) Secret
A well-endowed woman goes in search of a new sports bra
by Faye Jones
December 15, 2014 It is a truth universally acknowledged that a woman of a certain chest size will always be in a want of a well-fitting bra. This axiom is never truer than when said woman is a runner in need of a new sports bra.
Published Monday, 15 December 2014
Hey, Baby Doll
A son serves as witness to his parents' enduring love
by Hadley Hury
December 12, 2014 My mother understood that my father's death was at hand. For my part, I understood that their love for one another and their straightforward, practical faith would see them through this profoundest of transitions.
Published Friday, 12 December 2014
My (Fictional) Home
I learned to be a serious novelist when I moved to Tennessee
by Tasha Alexander
October 20, 2014 After college, I moved a dozen times—from Indiana to New Jersey, Wyoming, Vermont, Connecticut, and Tennessee—before settling in Chicago. Each of these places etched themselves on my psyche, but Nashville, with its fruit tea, tangy barbeque, and hot chicken, was the place where I learned to be a writer.
Published Sunday, 19 October 2014
All Together Now
A Chapter 16 writer considers the collective spirit of the Southern Festival of Books
by Maria Browning
October 10, 2014 The Southern Festival of Books is big, varied, and one of the most inclusive cultural events around. Chapter 16's Maria Browning considers the special pleasure of the festival's collective spirit. The twenty-sixth annual Southern Festival of Books will take place in Nashville October 10-12, 2014, at Legislative Plaza and the Nashville Public Library. All festival events are free and open to the public.
Published Thursday, 9 October 2014
The Cost of a Thing
Decades after first reading Walden, Michael Sims still finds Henry David Thoreau exciting and challenging, maddening and inspiring
by Michael Sims
August 18, 2014 When I first read Thoreau as a teenager, I quickly realized that I had found a magic carpet to my own rural Tennessee world. Henry helped me see and hear and smell my own woodland paths, and my own pond, with fresh senses. He brought a deeply poetic sensibility and a fine education to bear on observing the passenger pigeon and red squirrel, and I tried to apply his way of looking to my own rose-breasted grosbeaks and box turtles.
Published Sunday, 17 August 2014
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Publications (41)124.66 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: Emerging lines of evidence have shown that extracellular vesicles (EVs) mediate cell-to-cell communication by exporting encapsulated materials, such as microRNAs (miRNAs), to target cells. Endothelial cell-derived EVs (E-EVs) are upregulated in circulating blood in different pathological conditions; however, the characteristics and the role of these E-EVs are not yet well understood. In vitro studies were conducted to determine the role of inflammation-induced E-EVs in the cell-to-cell communication between vascular endothelial cells and pericytes/vSMCs. Stimulation with inflammatory cytokines and endotoxin immediately induced release of shedding type E-EVs from the vascular endothelial cells, and flow cytometry showed that the induction was dose dependent. MiRNA array analyses revealed that group of miRNAs were specifically increased in the inflammation-induced E-EVs. E-EVs added to the culture media of cerebrovascular pericytes were incorporated into the cells. The E-EV-supplemented cells showed highly induced mRNA and protein expression of VEGF-B, which was assumed to be a downstream target of the miRNA that was increased within the E-EVs after inflammatory stimulation. The results suggest that E-EVs mediate inflammation-induced endothelial cell-pericyte/vSMC communication, and the miRNAs encapsulated within the E-EVs may play a role in regulating target cell function. E-EVs may be new therapeutic targets for the treatment of inflammatory diseases.Scientific reports. 01/2015; 5:8505. -
Article: Nicotine Suppresses Acute Colitis and Colonic Tumorigenesis Associated with Chronic Colitis in Mice.
[Show abstract] [Hide abstract]
ABSTRACT: Ulcerative colitis is a chronic inflammatory disease that frequently progresses to colon cancer. The tumor-promoting effect of inflammation is now widely recognized and understood. Recent studies have revealed that treatment with nicotine ameliorates colitis in humans and experimental murine models, whereas the effect of nicotine on colitis-associated colonic tumorigenesis remains unclear. In the present study, we examined the effect of nicotine on the development of acute colitis and colitis-associated cancer (CAC). The acute colitis model was induced by treatment with 3% dextran sulfate sodium (DSS) for 7 days, whereas the CAC model was induced by a combination of azoxymethane and repeated DSS treatment. Nicotine and a selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) reduced the severity of DSS-induced acute colonic inflammation. In addition, the suppressive effect of nicotine on acute colitis was attenuated by an antagonist of α7nAChR. Furthermore, nicotine inhibited the IL-6 production of CD4 T cells in the DSS-induced inflamed colonic mucosa. We found that nicotine significantly reduced the number and size of colonic tumors in mice with CAC. Nicotine markedly inhibited the elevation of TNF-α and IL-6 mRNA as well as phosphorylated Stat3 expression in the colons of the tumor model mice. These results demonstrate that nicotine suppresses acute colitis and colitis-associated tumorigenesis, and this effect may be associated with the activation of α7nAChR. Furthermore, it is presumed that nicotine downregulates the expression of inflammatory mediators such as IL-6/Stat3 and TNF-α, thereby reducing the colonic tumorigenesis associated with chronic colitis.The American journal of physiology 09/2014; · 3.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Diabetes mellitus is the leading cause of blindness and end-stage renal disease. To understand the pathogenesis of diabetic complications, suitable animal models for this disease have been needed. The activation of Ca2+/ calmodulin-dependent protein kinase II (CaMKII) in pancreatic β-cells has been thought to play a central role in Ca2+-mediated insulin secretion. We generated transgenic mice over expressing the constitutively active-type CaMKIIα (Thr286Asp) in β-cells, which showed very high plasma glucose levels and exhibited the features of diabetic nephropathy and retinopathy. In cDNA microarray analysis osteopontin mRNA increased in CaMKIIα transgenic mice. In quantitative real-time RT-PCR analyses, not only M1 macrophage marker genes but also M2 macrophage marker genes were over expressed in renal cortex of CaMKIIα transgenic mice. The mice were crossed with conditional knockout mice in which platelet-derived growth factor receptor-β gene (Pdgfr-β) was deleted postnatal. The increased oxidative stress in the kidneys of the CaMKII α transgenic mice, which was shown by the increased urinary 8-hydroxydeoxyguanosine excretion and the increased expression of NAD (P) H oxidase 4, was decreased by Pdgfr-β deletion. The CaMKIIα (Thr286Asp) transgenic mice will be valuable as a novel model of severe insulin-dependent diabetes accompanied by an early progression of diabetic micro vascular complications.Austin Journal of Endocrinology and Diabetes. 01/2014; 1(1):9. - [Show abstract] [Hide abstract]
ABSTRACT: Because the renin-angiotensin-aldosterone system has been implicated in the development of insulin resistance and promotion of fibrosis in some tissues, such as the vasculature, we examined the effect of eplerenone, a selective mineralocorticoid receptor (MR) antagonist, on non-alcoholic steatohepatitis (NASH) and metabolic phenotypes in a mouse model reflecting metabolic syndrome in humans. We adopted liver-specific transgenic mice overexpressing the active form of sterol response element binding protein 1c (SREBP1c) fed a high-fat and fructose diet (HFFD) as the animal model in the present study. When wild-type (WT) C57BL/6 and liver-specific SREBP1c transgenic (Tg) mice grew while being fed HFFD for 12 weeks, body weight and epididymal fat weight increased in both groups with an elevation in blood pressure and dyslipidemia. Glucose intolerance and insulin resistance were also observed. Adipose tissue hypertrophy and macrophage infiltration with crown-like structure formation were also noted in mice fed HFFD. Interestingly, the changes noted in both genotypes fed HFFD were significantly ameliorated with eplerenone. HFFD-fed Tg mice exhibited the histological features of NASH in the liver, including macrovesicular steatosis and fibrosis, whereas HFFD-fed WT mice had hepatic steatosis without apparent fibrotic changes. Eplerenone effectively ameliorated these histological abnormalities. Moreover, the direct suppressive effects of eplerenone on lipopolysaccharide-induced TNFalpha production in the presence and absence of aldosterone were observed in primary-cultured Kupffer cells and bone marrow-derived macrophages. These results indicated that eplerenone prevented the development of NASH and metabolic abnormalities in mice by inhibiting inflammatory responses in both Kupffer cells and macrophages.AJP Endocrinology and Metabolism 10/2013; · 4.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Cilostazol, an inhibitor of phosphodiesterase 3B, is widely used as an anti-platelet drug in diabetic patients. Recently, cilostazol has been shown to promote preadipocyte differentiation to mature adipocyte and affect glucose homeostasis; therefore, we examined the impact of cilostazol on impaired glucose metabolism in adipose tissues of diabetic db/db mice. Administration of cilostazol at 100-300mg/kg/day significantly improved glucose tolerance and insulin sensitivity in a dose-dependent manner in db/db mice, whereas these effects were not observed in non-diabetic control mice. Cilostazol reduced the adipocyte size and suppressed mRNA expressions of monocyte chemoattractant protein 1, CD11c, and tumor necrosis factor α (TNFα) in the epididymal fat tissue of db/db mice. As for the cellular mechanism, cilostazol attenuated lipopolysaccharide (LPS)-induced TNFα expression by decreasing the mRNA and protein levels of Toll-like receptor 4 in Raw264.3 macrophages. Cilostazol also effectively ameliorated the TNFα-induced decrease of insulin-stimulated Akt phosphorylation and [(3)H]2-deoxyglucose uptake by suppressing c-Jun N terminal kinase-mediated serine phosphorylation of insulin receptor substrate 1 in 3T3-L1 adipocytes. Importantly, the improvement of impaired insulin signaling was blunted by pretreatment with KT5720, a protein kinase A inhibitor, but not with GW9662, a peroxisome proliferator-activated receptor γ. These results indicate that cilostazol suppressed TNFα production from macrophages and attenuated TNFα-induced chronic inflammation in adipose tissue, leading to the improvement of glucose intolerance and insulin resistance in obese diabetic mice. Thus, the present study reveals an additional benefit in the use of cilostazol in the treatment of patients with type 2 diabetes.European journal of pharmacology 03/2013; · 2.59 Impact Factor -
Article: Functional Analysis of Platelet-Derived Growth Factor Receptor-β in Neural Stem/Progenitor Cells.
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ABSTRACT: Activation of neural stem/progenitor cells (NSPCs) is a potential therapeutic strategy of neurological disorders. In this study, NSPCs of subventricular zone were isolated and cultured from platelet-derived growth factor-β-receptor-knockout (PDGFR-β-/-) mice of postnatal day 1 (P1) and P28, and the roles of PDGFR-β were examined in these cells. In PDGFR-β-preserving control NSPCs, stem cell activities, such as numbers and diameters of secondary neurospheres, cell proliferation and survival rates, were significantly higher in P1 NSPCs than those in P28 NSPCs. In PDGFR-β-/- NSPCs, most of these parameters were decreased as compared with age-matched controls. Among them, the decrease of secondary neurosphere formation was most striking in P1 and P28 PDGFR-β-/- NSPCs and in P28 control NSPCs as compared with P1 control NSPCs. PCR-array and following qRT-PCR analyses demonstrated that expressions of fibroblast growth factor-2 (FGF2) and exons IV-IX of brain-derived neurotrophic factor (BDNF) were decreased, and noggin was increased in P1 PDGFR-β-/- as compared with P1 controls. Addition of BDNF rescued the number and diameter of secondary neurospheres in P1 PDGFR-β-/- NSPCs to similar levels as controls. The expressions of PDGFs and PDGFRs in control NSPCs were increased along with the differentiation-induction, where phosphorylated PDGFR-β was co-localized with neuronal and astrocyte differentiation markers. In controls, the neuronal differentiation was decreased, and the glial differentiation was increased from P1 to P28 NSPCs. Compared with P1 controls, neuronal differentiation was reduced in P1 PDGFR-β-/- NSPCs, whereas glial differentiation was comparable between the two genotypes. These results suggest that PDGFR-β signaling is important for the self-renewal and multipotency of NSPCs, particularly in neonatal NSPCs. BDNF, FGF2, and noggin may be involved in the effects of PDGFR-β signaling in these cells. Accordingly, the activation of PDGFR-β in NSPCs may be a novel therapeutic strategy of neurological diseases.Neuroscience 02/2013; · 3.33 Impact Factor -
Article: PDGF Suppresses Oxidative Stress Induced Ca(2+) Overload and Calpain Activation in Neurons.
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ABSTRACT: Oxidative stress is crucially involved in the pathogenesis of neurological diseases such as stroke and degenerative diseases. We previously demonstrated that platelet-derived growth factors (PDGFs) protected neurons from H2O2-induced oxidative stress and indicated the involvement of PI3K-Akt and MAP kinases as an underlying mechanism. Ca(2+) overload has been shown to mediate the neurotoxic effects of oxidative stress and excitotoxicity. We examined the effects of PDGFs on H2O2-induced Ca(2+) overload in primary cultured neurons to further clarify their neuroprotective mechanism. H2O2-induced Ca(2+) overload in neurons in a dose-dependent manner, while pretreating neurons with PDGF-BB for 24 hours largely suppressed it. In a comparative study, the suppressive effects of PDGF-BB were more potent than those of PDGF-AA. We then evaluated calpain activation, which was induced by Ca(2+) overload and mediated both apoptotic and nonapoptotic cell death. H2O2-induced calpain activation in neurons in a dose-dependent manner. Pretreatment of PDGF-BB completely blocked H2O2-induced calpain activation. To the best of our knowledge, the present study is the first to demonstrate the mechanism underlying the neuroprotective effects of PDGF against oxidative stress via the suppression of Ca(2+) overload and inactivation of calpain and suggests that PDGF-BB may be a potential therapeutic target of neurological diseases.Oxidative Medicine and Cellular Longevity 01/2013; 2013:367206. - [Show abstract] [Hide abstract]
ABSTRACT: The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and β subunit of receptors of platelet-derived growth factor (PDGFR- β ) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR- β -knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR- β KO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR- β KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR- β KO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR- β KO mice. These findings suggest that PDGFR- β plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.BioMed research international. 01/2013; 2013:848265. - [Show abstract] [Hide abstract]
ABSTRACT: Age-related loss of ovarian function promotes adiposity and insulin resistance in women. Estrogen (E(2)) directly enhances insulin sensitivity and suppresses lipogenesis in peripheral tissues. Recently, the central actions of E(2) in the regulation of energy homeostasis are becoming clearer; however, the functional relevance and degree of contribution of the central vs. peripheral actions of E(2) are currently unknown. Therefore, we prepared and analyzed four groups of mice. 1) Control: sham-operated mice fed a regular diet, 2) OVX-HF: ovariectomized (OVX) mice fed a 60% high-fat diet (HF), 3) E2-SC: OVX-HF mice subcutaneously treated with E(2), and 4) E2-ICV: OVX-HF mice treated with E(2) intracerebroventricularly. OVX-HF mice showed increased body weight with both visceral and subcutaneous fat volume enlargement, glucose intolerance, and insulin resistance. Both E2-SC and E2-ICV equally ameliorated these abnormalities. Although the size of adipocytes and number of CD11c-positive macrophages in perigonadal fat in OVX-HF were reduced by both E(2) treatments, peripherally administered E(2) decreased the expression of TNFα, lipoprotein lipase, and fatty acid synthase in the white adipose tissue (WAT) of OVX-HF. In contrast, centrally administered E(2) increased hormone-sensitive lipase in WAT, decreased the hepatic expression of gluconeogenic enzymes, and elevated core body temperature and energy expenditure with marked upregulation of uncoupling proteins in the brown adipose tissue. These results suggest that central and peripheral actions of E(2) regulate insulin sensitivity and glucose metabolism via different mechanisms, and their coordinated effects may be important to prevent the development of obesity and insulin resistance in postmenopausal women.AJP Endocrinology and Metabolism 05/2012; 303(4):E445-56. · 4.51 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The physiological role of platelet-derived growth factor (PDGF) in the central nervous system (CNS) synaptic function remains uncharacterized. Here we identify physiological roles of PDGF receptor-β (PDGFR-β) in the CNS by conditional knockout of the gene encoding it. In the hippocampus, PDGFR-β colocalized immunohistochemically with both presynaptic synaptophysin and postsynaptic density-95 (PSD-95). In the hippocampal CA1 region, expression levels of postsynaptic proteins, including spinophilin, drebrin, and PSD-95, were significantly decreased in PDGFR-β knockout mice, although presynaptic synaptophysin levels remained comparable to controls. Interestingly, in hippocampal CA1 pyramidal neurons, dendritic spine density in PDGFR-β knockout mice was significantly decreased compared with that seen in wild-type mice, although spine length and number of dendritic branches remained unchanged. Consistent with these findings, impairment in hippocampal long-term potentiation (LTP) and in hippocampus-dependent memory formation were seen in PDGFR-β knockout mice. These results suggest PDGFR-β plays critical roles in spine morphology and memory formation in mouse brain.Hippocampus 10/2011; 22(6):1371-8. · 4.30 Impact Factor -
Article: PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia.
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ABSTRACT: Although platelet-derived growth factors (PDGFs) and receptors (PDGFRs) are abundantly expressed in the central nervous system, their functions largely remain elusive. We investigated the role of PDGFR-β in tissue responses and functional recovery after photothrombolic middle cerebral artery occlusion (MCAO). In the normal adult mouse brain, PDGFR-β was mainly localized in neurons and in pericyte/vascular smooth muscle cells (PC/vSMCs). From 3 to 28 days after MCAO, postnatally induced systemic PDGFR-β knockout mice (Esr-KO) exhibited the delayed recovery of body weight and behavior, and larger infarction volume than controls. In Esr-KO, PC/vSMC coverage was decreased and vascular leakage of infused fluorescent-labeled albumin was extensive within the ischemic lesion, but not in the uninjured cerebral cortex. Angiogenesis levels were comparable between Esr-KO and controls. In another PDGFR-β conditional KO mouse (Nestin-KO), PDGFR-β was deleted in neurons and astrocytes from embryonic day 10.5, but was preserved in PC/vSMCs. After MCAO, vascular leakage and infarction volume in Nestin-KO were worse than controls, but partly improved compared with Esr-KO. Astroglial scar formation in both Esr-KO and Nestin-KO was similarly reduced compared with controls after MCAO. These data suggested that PDGFR-β signaling is crucial for neuroprotection, endogenous tissue repair, and functional recovery after stroke by targeting neurons, PC/vSMCs, and astrocytes.Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 09/2011; 32(2):353-67. · 5.46 Impact Factor -
Article: PDGFR-β is essential for recruitment, but not for survival of pericyte in adult mouse brain
Neuroscience Research 09/2011; 71. · 2.15 Impact Factor - Neuroscience Research 09/2011; 71. · 2.15 Impact Factor
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ABSTRACT: Mutations of the ATRX gene, which encodes an ATP-dependent chromatin-remodeling factor, were identified in patients with α-thalassemia X-linked mental retardation (ATR-X) syndrome. There is a milder variant of ATR-X syndrome caused by mutations in the Exon 2 of the gene. To examine the impact of the Exon 2 mutation on neuronal development, we generated ATRX mutant (ATRX(ΔE2)) mice. Truncated ATRX protein was produced from the ATRX(ΔE2) mutant allele with reduced expression level. The ATRX(ΔE2) mice survived and reproduced normally. There was no significant difference in Morris water maze test between wild-type and ATRX(ΔE2) mice. In a contextual fear conditioning test, however, total freezing time was decreased in ATRX(ΔE2) mice compared to wild-type mice, suggesting that ATRX(ΔE2) mice have impaired contextual fear memory. ATRX(ΔE2) mice showed significantly reduced long-term potentiation in the hippocampal CA1 region evoked by high-frequency stimulation. Moreover, autophosphorylation of calcium-calmodulin-dependent kinase II (αCaMKII) and phosphorylation of glutamate receptor, ionotropic, AMPA 1 (GluR1) were decreased in the hippocampi of the ATRX(ΔE2) mice compared to wild-type mice. These findings suggest that ATRX(ΔE2) mice may have fear-associated learning impairment with the dysfunction of αCaMKII and GluR1. The ATRX(ΔE2) mice would be useful tools to investigate the role of the chromatin-remodeling factor in the pathogenesis of abnormal behaviors and learning impairment.Hippocampus 06/2011; 21(6):678-87. · 4.30 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Platelet-derived growth factor (PDGF) is a potent mitogen. Extensive in vivo studies of PDGF and its receptor (PDGFR) genes have reported that PDGF plays an important role in embryogenesis and development of the central nervous system (CNS). Furthermore, PDGF and the β subunit of the PDGF receptor (PDGFR-β) have been reported to be associated with schizophrenia and autism. However, no study has reported on the effects of PDGF deletion on mice behavior. Here we generated novel mutant mice (PDGFR-β KO) in which PDGFR-β was conditionally deleted in CNS neurons using the Cre/loxP system. Mice without the Cre transgene but with floxed PDGFR-β were used as controls. Both groups of mice reached adulthood without any apparent anatomical defects. These mice were further examined by conducting several behavioral tests for spatial memory, social interaction, conditioning, prepulse inhibition, and forced swimming. The test results indicated that the PDGFR-β KO mice show deficits in all of these areas. Furthermore, an immunohistochemical study of the PDGFR-β KO mice brain indicated that the number of parvalbumin (calcium-binding protein)-positive (i.e., putatively γ-aminobutyric acid-ergic) neurons was low in the amygdala, hippocampus, and medial prefrontal cortex. Neurophysiological studies indicated that sensory-evoked gamma oscillation was low in the PDGFR-β KO mice, consistent with the observed reduction in the number of parvalbumin-positive neurons. These results suggest that PDGFR-β plays an important role in cognitive and socioemotional functions, and that deficits in this receptor may partly underlie the cognitive and socioemotional deficits observed in schizophrenic and autistic patients.PLoS ONE 03/2011; 6(3):e18004. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Mesangial cell functions are critically regulated by platelet-derived growth factor receptor (PDGFR)-β signals. In contrast to the well-established role of PDGFR-β in the development of kidney glomerulus, its role in adult kidney glomerulus remains controversial. We deleted the PDGFR-β gene postnatally using the Cre-loxP system and analysed the long-term effects of PDGFR-β inhibition on glomerular changes associated with ageing and subtotal nephrectomy. Mice depleted of PDGFR-β (Deletant) survived without showing apparent abnormalities. In glomerulus of Deletant, mesangial PDGFR-β expression was decreased. The glomerular cell numbers were low, and the ageing-associated increment of mesangial matrix area was suppressed in Deletant as compared with control mice with conserved PDGFR-β expression (Floxed) at 48 weeks of age. At 2 weeks after subtotal nephrectomy, albuminuria and the elevation of blood urea nitrogen were aggravated in Deletant. At this time, Deletant showed specific glomerular changes that included many hypertrophic podocytes and collapsed capillaries. At 12 weeks after subtotal nephrectomy, the kidney function in Deletant restored to the level of Floxed; however, the Deletant glomeruli showed dilated capillaries, decreased cell number and reduced mesangial matrix area with less extended mesangial cell processes as compared with Floxed. The long-term inhibition of mesangial PDGFR-β prevented age-related mesangial expansion. On the other hand, the kidney glomeruli with decreased PDGFR-β showed increased vulnerability to the acute nephron loss, and showed mesangial insufficiency in the following adaptive process.Nephrology Dialysis Transplantation 02/2011; 26(2):458-68. · 3.37 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Since ovarian cancer during pregnancy is rare, the decisions regarding pregnancy discontinuation or fertility preservation are often difficult. We report three ovarian cancer cases detected at early, mid and late pregnancy periods in which both babies and mothers were saved. In particular, case 2 is the first reported instance of a sertoliform endometrioid carcinoma of the ovary during pregnancy. In addition, we review the clinical characteristics of previously reported patients with stage I ovarian cancer diagnosed during pregnancy. Even with stage Ia ovarian cancer, restaging laparotomy at cesarean section or post-delivery may be important to determine the treatment plan because staging during pregnancy is rarely complete.Journal of Obstetrics and Gynaecology Research 12/2010; 37(6):650-5. · 0.84 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Loss of the q22 band of chromosome 16 is a frequent genetic event in breast cancer, and the candidate tumor suppressor gene, ATBF1, has been implicated in breast cancer by genomic deletion, transcriptional down-regulation, and association with better prognostic parameters. In addition, estrogen receptor (ER)-positive breast cancer expresses a higher level of ATBF1, suggesting a role of ATBF1 in ER-positive breast cancer. In this study, we examined whether and how ATBF1 affects the ER function in breast cancer cells. We found that ATBF1 inhibited ER-mediated gene transcription, cell growth, and proliferation in ER-positive breast cancer cells. In vitro and in vivo immunoprecipitation experiments revealed that ATBF1 interacted physically with the ER and that multiple domains in both ATBF1 and ER proteins mediated the interaction. Furthermore, we demonstrated that ATBF1 inhibited ER function by selectively competing with the steroid receptor coactivator AIB1 but not GRIP1 or SRC1 for binding to the ER. These findings not only support the concept that ATBF1 plays a tumor-suppressive role in breast cancer, they also provide a mechanism for how ATBF1 functions as a tumor suppressor in breast cancer.Journal of Biological Chemistry 10/2010; 285(43):32801-9. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The role of platelet-derived growth factor (PDGF)-BB / PDGF receptor (PDGFR)-beta signal in inhibition of synaptic transmission by hypoxia is unclear. In the nucleus tractus solitarius neurons, hypoxia with N(2) or NaCN decreased the amplitude of excitatory postsynaptic currents (EPSCs) similarly in wild type (WT) and PDGFR-beta gene-knockout (KO) mice. Recovery of EP SCs after a high concentration of NaCN in KO mice was significantly faster than that in WT mice, while recovery after a low concentration of NaCN or N(2) was not different between both mice. These results suggest that the PDGF-BB / PDGFR-beta signal modulates the excitatory synaptic transmission during hypoxia.Journal of Pharmacological Sciences 03/2010; 112(4):477-81. · 2.11 Impact Factor - Neuroscience Research 01/2010; 68:e97. · 2.15 Impact Factor
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Dawson said that some people make the mistake that growing their own strength means pushing others down in the process. While some people may do that, Dawson said that it is not necessary to stomp on others to succeed.
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It doesn't necessarily mean cutting a check to charity or volunteering your time, though that can be part of it, Dawson said. It can be as simple as being nice to those around you, she said.
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Persuasion and Power
EXPLORE THIS TITLE DescriptionTable of Contents Reviews |
304 pp., 6 x 9 Paperback ISBN: 9781589019423 (1589019423) eBook ISBN: 9781589019430 November 2012 LC: 2012007819 Audio Excerpt:
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Persuasion and Power
The Art of Strategic Communication
James P. Farwell
Foreword by John J. Hamre Now more than ever, in the arenas of national security, diplomacy, and military operations, effective communication strategy is of paramount importance. A 24/7 television, radio, and Internet news cycle paired with an explosion in social media demands it. James P. Farwell is an expert in communication strategy and cyber war who advises the US Department of Defense and the US Special Operations Command on a range of global initiatives and actions, including strategic communication. He is also a senior research fellow in strategic studies at the Canada Centre for Global Security Studies in the Munk School of Global Affairs at the University of Toronto. He is the author of the highly acclaimed The Pakistan Cauldron: Conspiracy, Assassination, and Instability.
"The strength of Persuasion and Power is its exhaustive research, reflected in numerous vignettes and research that compellingly illustrate successful concepts, benefits, and failures of strategic communication. Scholars and strategic communicators alike will be impressed with Farewell's research and proposed solutions to enhance strategic communication. Persuasion and Power is a must-read for those with an interest in strategic communication."—Military Review "Farwell offers a sophisticated analysis, richly illustrated with examples and anecdotes."—Survival "If you're involved in politics, public affairs, business or marketing, I highly recommend you read this book and hope your competition doesn't."—Councilman Todd A. Kinsey "This book is thorough, scholarly, informative, and well written."—Choice "Persuasion and Power is an informed, informative, thoughtful, thought-provoking, and an absolutely recommended addition to professional, NGO, governmental, academic, and community library Political Science and Communication reference collections."—Midwest Book Review "A top expert on strategic communication, James Farwell combines superb scholarship with concise, vibrant writing in this riveting study of how leaders from antiquity to today have employed the principles of communication. It's a great read, sharply insightful, and immensely informative."—Ambassador Gilbert A. Robinson (ret.) "Again James Farwell connects today's dots with the perplexing challenges of strategic communications. Every kinetic strike must have a strategic message. So much so that the message is more powerful than the strike. That is the insight that Farwell provides along with so many others. A must read for public relations officers, military information officers, and all of today's and tomorrow's leaders."—Lt. Gen. Dell L. Dailey, USA (Ret.), former director, Center for Special Operations, US Special Operations command; former ambassador-at-large and coordinator for counterterrorism, State Department "A timely examination of contemporary American strategic communication, Persuasion and Power draws on case studies ripped from the headlines of the last decade. No other book on the strategic communication shelf so clearly lays out the approaches, jargon, tools, and techniques used by State Department diplomats, military officers, and aid workers one finds on the ground in almost every foreign country."—Amb. Brian E. Carlson, defense and diplomacy specialist, InterMedia Research Institute "There is an art to effective communication, to be sure, but art without a strategic objective is of dubious merit. In this intelligent and sweeping book, James P. Farwell provides profound insights into how different countries, cultures, and institutions use words and deeds to inform and shape the ideas, values, and actions of others."—William S. Cohen, former Secretary of Defense Table of Contents Foreword John J. Hamre Introduction PART I: THE FORMS OF STRATEGIC COMMUNICATION 1. Psychological Operations 2. Propaganda: The Resonance of Emotion 3. Public Affairs: Concept versus Reality 4. Public Diplomacy PART II: WORDS, IMAGES AND SYMBOLS, AND DEEDS 5. Words 6. Images and Symbols 7. Deeds PART III: CAMPAIGNS OF INFLUENCE 8. Do Authoritarians Care? 9. Is Success about Leadership or Communication? 10. The Marks of Leadership 11. Campaigns of Influence 12. Defining Winning or Losing 13. Strategy 14. Tactics PART IV: WEAPONS OF STRATEGIC COMMUNICATION 15.Television as a Weapon 16. Radio as a Weapon PART V: MORE EFFECTIVE STRATEGIC COMMUNICATION 17. Change that Would Matter 18. Conclusion Notes About the Author Index |


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Kate Middleton Nails Wedding-Guest Beauty Style
At 32 years old, Kate Middleton's hair is as flawless as ever. It seems every time she steps out, the Duchess of Cambridge inspires our hair envy. From her wedding day to the queen's Diamond Jubilee to her postmaternity appearances, get your fill of hair inspiration with a look back at Kate's best blowouts.
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