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Publications (25)203.48 Total impact
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ABSTRACT: Abstract Anopheles gambiae has a well-adapted system for host localization, feeding, and mating behavior, which are all governed by neuronal processes in the brain. However, there are no published reports characterizing the brain proteome to elucidate neuronal signaling mechanisms in the vector. To this end, a large-scale mapping of the brain proteome of An. gambiae was carried out using high resolution tandem mass spectrometry, revealing a repertoire of >1800 proteins, of which 15% could not be assigned any function. A large proportion of the identified proteins were predicted to be involved in diverse biological processes including metabolism, transport, protein synthesis, and olfaction. This study also led to the identification of 10 GPCR classes of proteins, which could govern sensory pathways in mosquitoes. Proteins involved in metabolic and neural processes, chromatin modeling, and synaptic vesicle transport associated with neuronal transmission were predominantly expressed in the brain. Proteogenomic analysis expanded our findings with the identification of 15 novel genes and 71 cases of gene refinements, a subset of which were validated by RT-PCR and sequencing. Overall, our study offers valuable insights into the brain physiology of the vector that could possibly open avenues for intervention strategies for malaria in the future.Omics A Journal of Integrative Biology 06/2014; · 2.73 Impact Factor -
Article: A draft map of the human proteome
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ABSTRACT: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.Nature 01/2014; 509:575-81. · 42.35 Impact Factor -
Article: Annotation of the zebrafish genome through an integrated transcriptomic and proteomic analysis
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ABSTRACT: Accurate annotation of protein-coding genes is one of the primary tasks upon completion of whole genome sequencing of any organism. In this study, we used an integrated transcriptomic and proteomic strategy to validate and improve the existing zebrafish genome annotation. We undertook high resolution mass spectrometry-based proteomic profiling of ten adult organs, whole adult fish body and two developmental stages of zebrafish (SAT line) in addition to transcriptomic profiling of six organs. More than 7,000 proteins were identified from proteomic analyses and ~69,000 high confidence transcripts were assembled from the RNA-Seq data. Approximately 15% of the transcripts mapped to intergenic regions, the majority of which are likely long non-coding RNAs. These high quality transcriptomic and proteomic data were used to manually re-annotate the zebrafish genome. We report identification of 157 novel protein-coding genes. In addition, our data led to modification of existing gene structures which include novel exons, change in exon coordinates, change in frame of translation, translation in annotated UTRs and joining of genes. Finally, we discovered four instances of genome assembly errors that were supported by both proteomic and transcriptomic data. Our study shows how an integrative analysis of the transcriptome and the proteome can extend our understanding of even well-annotated genomes.Molecular & Cellular Proteomics 01/2014; · 7.25 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To optimize the combination of ionizing radiation and cellular immunotherapy using a preclinical autochthonous model of prostate cancer. Transgenic mice expressing a model antigen under a prostate-specific promoter were treated using a platform that integrates cone-beam CT imaging with 3-dimensional conformal therapy. Using this technology we investigated the immunologic and therapeutic effects of combining ionizing radiation with granulocyte/macrophage colony-stimulating factor-secreting cellular immunotherapy for prostate cancer in mice bearing autochthonous prostate tumors. The combination of ionizing radiation and immunotherapy resulted in a significant decrease in pathologic tumor grade and gross tumor bulk that was not evident with either single-modality therapy. Furthermore, combinatorial therapy resulted in improved overall survival in a preventive metastasis model and in the setting of established micrometastases. Mechanistically, combined therapy resulted in an increase of the ratio of effector-to-regulatory T cells for both CD4 and CD8 tumor-infiltrating lymphocytes. Our preclinical model establishes a potential role for the use of combined radiation-immunotherapy in locally advanced prostate cancer, which warrants further exploration in a clinical setting.International journal of radiation oncology, biology, physics 09/2013; · 4.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the treatment of metastatic melanoma. This decision was based on Phase III results, which demonstrate that blocking this immune checkpoint provides a survival advantage in patients with advanced disease. As a single agent, ipilimumab is also being clinically evaluated in advanced (metastatic, castrate-resistant) prostate cancer and two randomized, placebo-controlled Phase III studies have recently completed accrual. METHODS: We used a well-described genetically engineered mouse (GEM), autochronous prostate cancer model (Pro-TRAMP) to explore the relative sequencing and dosing of anti-CTLA-4 antibody when combined with a cell-based, GM-CSF-secreting vaccine (GVAX). RESULTS: Our results show that combined treatment results in a dramatic increase in effector CD8 T cells in the prostate gland, and enhanced tumor-antigen directed lytic function. These effects are maximized when CTLA-4 blockade is applied after, but not before, vaccination. Additional experiments, using models of metastatic disease, show that incorporation of low-dose cyclophosphamide into this combined treatment regimen results in an additional pre-clinical benefit. CONCLUSIONS: Together these studies define a combination regimen using anti-CTLA-4 / GVAX immunotherapy and low-dose chemotherapy for potential translation to a clinical trial setting.Journal of Translational Medicine 04/2013; 11(1):89. · 3.99 Impact FactorThis article is viewable in ResearchGate's enriched format -
Article: Rapid Characterization of Candidate Biomarkers for Pancreatic Cancer Using Cell Microarrays (CMAs).
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ABSTRACT: Tissue microarrays have become a valuable tool for high-throughput analysis using immunohistochemical labeling. However, the large majority of biochemical studies are carried out in cell lines to further characterize candidate biomarkers or therapeutic targets with subsequent studies in animals or using primary tissues. Thus, cell line-based microarrays could be a useful screening tool in some situations. Here, we constructed a cell microarray (CMA) containing a panel of 40 pancreatic cancer cell lines available from American Type Culture Collection in addition to those locally available at Johns Hopkins. As proof of principle, we performed immunocytochemical labeling of an epithelial cell adhesion molecule (Ep-CAM), a molecule generally expressed in the epithelium, on this pancreatic cancer CMA. In addition, selected molecules that have been previously shown to be differentially expressed in pancreatic cancer in the literature were validated. For example, we observed strong labeling of CA19-9 antigen, a prognostic and predictive marker for pancreatic cancer. We also carried out a bioinformatics analysis of a literature curated catalog of pancreatic cancer biomarkers developed previously by our group and identified two candidate biomarkers, HLA class I and transmembrane protease, serine 4 (TMPRSS4), and examined their expression in the cell lines represented on the pancreatic cancer CMAs. Our results demonstrate the utility of CMAs as a useful resource for rapid screening of molecules of interest and suggest that CMAs can become a universal standard platform in cancer research.Journal of Proteome Research 09/2012; · 5.06 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Helios, an Ikaros family transcription factor, is preferentially expressed at the mRNA and protein level in regulatory T cells. Helios expression previously appeared to be restricted to thymic-derived Treg. Consistent with recent data, we show here that Helios expression is inducible in vitro under certain conditions. To understand phenotypic and functional differences between Helios(+) and Helios(-) Treg, we profiled cell-surface markers of FoxP3(+) Treg using unmanipulated splenocytes. We found that CD103 and GITR are expressed at high levels on a subset of Helios(+) Treg and that a Helios(+) Treg population could be significantly enriched by FACS sorting using these two markers. Quantitative real-time PCR (qPCR) analysis revealed increased TGF-β message in Helios(+) Treg, consistent with the possibility that this population possesses enhanced regulatory potential. In tumor-bearing mice, we found that Helios(+) Treg were relatively over-represented in the tumor-mass, and BrdU studies showed that, in vivo, Helios(+) Treg proliferated more than Helios(-) Treg. We hypothesized that Helios-enriched Treg might exert increased suppressive effects. Using in vitro suppression assays, we show that Treg function correlates with the absolute number of Helios(+) cells in culture. Taken together, these data show that Helios(+) Treg represent a functional subset with associated CD103 and GITR expression.PLoS ONE 03/2012; 7(3):e34547. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Dicer is a ribonuclease whose major role is to generate mature microRNAs, although additional functions have been proposed. Deletion of Dicer leads to embryonic lethality in mice. To study the role of Dicer in adults, we generated mice in which administration of tamoxifen induces deletion of Dicer. Surprisingly, disruption of Dicer in adult mice induced lipid accumulation in the small intestine. To dissect the underlying mechanisms, we carried out miRNA, mRNA, and proteomic profiling of the small intestine. The proteomic analysis was done using mice metabolically labeled with heavy lysine (SILAC mice) for an in vivo readout. We identified 646 proteins, of which 80 were up-regulated >2-fold and 75 were down-regulated. Consistent with the accumulation of lipids, Dicer disruption caused a marked decrease of microsomal triglyceride transfer protein, long-chain fatty acyl-CoA ligase 5, fatty acid binding protein, and very-long-chain fatty acyl-CoA dehydrogenase, among others. We validated these results using multiple reaction monitoring (MRM) experiments by targeting proteotypic peptides. Our data reveal a previously unappreciated role of Dicer in lipid metabolism. These studies demonstrate that a systems biology approach by integrating mouse models, metabolic labeling, gene expression profiling, and quantitative proteomics can be a powerful tool for understanding complex biological systems.Journal of Proteome Research 02/2012; 11(4):2193-205. · 5.06 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Thymic stromal lymphopoietin (TSLP) is a cytokine that plays diverse roles in the regulation of immune responses. TSLP requires a heterodimeric receptor complex consisting of IL-7 receptor α subunit and its unique TSLP receptor (gene symbol CRLF2) to transmit signals in cells. Abnormal TSLP signaling (e.g. overexpression of TSLP or its unique receptor TSLPR) contributes to the development of a number of diseases including asthma and leukemia. However, a detailed understanding of the signaling pathways activated by TSLP remains elusive. In this study, we performed a global quantitative phosphoproteomic analysis of the TSLP signaling network using stable isotope labeling by amino acids in cell culture. By employing titanium dioxide in addition to antiphosphotyrosine antibodies as enrichment methods, we identified 4164 phosphopeptides on 1670 phosphoproteins. Using stable isotope labeling by amino acids in cell culture-based quantitation, we determined that the phosphorylation status of 226 proteins was modulated by TSLP stimulation. Our analysis identified activation of several members of the Src and Tec families of kinases including Btk, Lyn, and Tec by TSLP for the first time. In addition, we report TSLP-induced phosphorylation of protein phosphatases such as Ptpn6 (SHP-1) and Ptpn11 (Shp2), which has also not been reported previously. Co-immunoprecipitation assays showed that Shp2 binds to the adapter protein Gab2 in a TSLP-dependent manner. This is the first demonstration of an inducible protein complex in TSLP signaling. A kinase inhibitor screen revealed that pharmacological inhibition of PI-3 kinase, Jak family kinases, Src family kinases or Btk suppressed TSLP-dependent cellular proliferation making them candidate therapeutic targets in diseases resulting from aberrant TSLP signaling. Our study is the first phosphoproteomic analysis of the TSLP signaling pathway that greatly expands our understanding of TSLP signaling and provides novel therapeutic targets for TSLP/TSLPR-associated diseases in humans.Molecular & Cellular Proteomics 02/2012; 11(6):M112.017764. · 7.25 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Anopheles gambiae is a major mosquito vector responsible for malaria transmission, whose genome sequence was reported in 2002. Genome annotation is a continuing effort, and many of the approximately 13,000 genes listed in VectorBase for Anopheles gambiae are predictions that have still not been validated by any other method. To identify protein-coding genes of An. gambiae based on its genomic sequence, we carried out a deep proteomic analysis using high-resolution Fourier transform mass spectrometry for both precursor and fragment ions. Based on peptide evidence, we were able to support or correct more than 6000 gene annotations including 80 novel gene structures and about 500 translational start sites. An additional validation by RT-PCR and cDNA sequencing was successfully performed for 105 selected genes. Our proteogenomic analysis led to the identification of 2682 genome search-specific peptides. Numerous cases of encoded proteins were documented in regions annotated as intergenic, introns, or untranslated regions. Using a database created to contain potential splice sites, we also identified 35 novel splice junctions. This is a first report to annotate the An. gambiae genome using high-accuracy mass spectrometry data as a complementary technology for genome annotation.Genome Research 07/2011; 21(11):1872-81. · 13.85 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Multinucleated cells are relatively resistant to classic apoptosis, and the factors initiating cell death and damage in myositis are not well defined. We hypothesized that nonimmune autophagic cell death may play a role in muscle fiber damage. Recent reports indicate that TRAIL may induce both NF-κB activation and autophagic cell death in other systems. We undertook this study to investigate the role of TRAIL in cell death and pathogenesis in vitro and in vivo, using myositis muscle tissues from humans and mice. Gene expression profiling was performed in myositis patient and control muscle specimens. Immunohistochemistry analysis was performed to confirm the gene array findings. We also analyzed TRAIL-induced cell death (apoptosis and autophagy) and NF-κB activation in vitro in cultured cells. TRAIL was expressed predominantly in myositis muscle fibers, but not in biopsy specimens from normal or other dystrophic-diseased muscle. Autophagy markers were up-regulated in humans with myositis and in mouse models of myositis. TRAIL expression was restricted to regenerating/atrophic areas of muscle fascicles, blood vessels, and infiltrating lymphocytes. TRAIL induced NF-κB activation and IκB degradation in cultured cells that are resistant to TRAIL-induced apoptosis but that undergo autophagic cell death. Our data demonstrate that TRAIL is expressed in myositis muscle and may mediate both activation of NF-κB and autophagic cell death in myositis. Thus, this nonimmune pathway may be an attractive target for therapeutic intervention in myositis.Arthritis & Rheumatology 07/2011; 63(11):3448-57. · 7.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The CD8 T-cell response to prostate and other cancers is often functionally diminished or absent. This may occur via deletion of tumor-specific T cells, through acquisition of an anergic phenotype, or via active suppression mediated by another population of cells. We used a double transgenic model in which mice express CD8 T cells specific for a prostate/prostate cancer antigen to study the response of CD8 T cells to evolving autochronous prostate tumors in TRAMP mice. CD8 T cells were analyzed for functionality by measuring IFN-γ production via flow cytometry and via an in vivo CTL killing assay. In addition, pathological scoring of the prostates of the double transgenic mice was compared to scoring of tumor burden prostates of ProTRAMP mice. Tumor-specific CD8 T cells were not grossly deleted in these animals, but evidenced a clearly non-functional phenotype. Interestingly, full lytic function was rapidly recovered upon removal from tumor-bearing mice. These data indicate a role for continuous antigen exposure in the maintenance of tumor-specific CD8 T-cell tolerance to prostate cancer.The Prostate 07/2011; 72(5):514-22. · 3.57 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of tumor necrosis factor (TNF) superfamily that plays a key role in the regulation of differentiation, activation and survival of osteoclasts and also in tumor cell migration and bone metastasis. Osteoclast activation induced by RANKL regulates hematopoietic stem cell mobilization as part of homeostasis and host defense mechanisms thereby linking regulation of hematopoiesis with bone remodeling. Binding of RANKL to its receptor, Receptor activator of nuclear factor-kappa B (RANK) activates molecules such as NF-kappa B, mitogen activated protein kinase (MAPK), nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K). Although the molecular and cellular roles of these molecules have been reported previously, a systematic cataloging of the molecular events induced by RANKL/RANK interaction has not been attempted. Here, we present a comprehensive reaction map of the RANKL/RANK-signaling pathway based on an extensive manual curation of the published literature. We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions.Database The Journal of Biological Databases and Curation 01/2011; 2011:bar021. · 4.46 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: Relative upregulation of the Ikaros family transcription factor Helios in natural regulatory T cells (Tregs) has been reported by several groups. However, a role for Helios in regulatory T cells has not yet been described. Here, we show that Helios is upregulated in CD4(+)CD25(+) regulatory T cells. Chromatin-immunoprecipitation (ChIP) experiments indicated that Helios binds to the FoxP3 promoter. These data were further corroborated by experiments showing that knocking-down Helios with siRNA oligonucleotides results in down-regulation of FoxP3. Functionally, we found that suppression of Helios message in CD4(+)CD25(+) T cells significantly attenuates their suppressive function. Taken together, these data suggest that Helios may play an important role in regulatory T cell function and support the concept that Helios may be a novel target to manipulate Treg activity in a clinical setting.Molecular Immunology 03/2010; 47(7-8):1595-600. · 3.00 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little is known regarding their functional characteristics. While Tc1 cells produced IFN-gamma and efficiently killed targets, Tc17 cells lacked lytic function in vitro. Interestingly, the small numbers of IFN-gamma-positive or IL-17/IFN-gamma-double-positive cells generated under Tc17 conditions also lacked lytic activity and expressed a similar pattern of cell surface proteins to IL-17-producing cells. As is the case for Th17 (CD4) cells, STAT3 is important for Tc17 polarization, both in vitro and in vivo. Adoptive transfer of highly purified, Ag-specific IL-17-secreting Tc17 cells into Ag-bearing hosts resulted in near complete conversion to an IFN-gamma-secreting phenotype and substantial pulmonary pathology, demonstrating functional plasticity. Tc17 also accumulated to a greater extent than did Tc1 cells, suggesting that adoptive transfer of CD8 T cells cultured in Tc17 conditions may have therapeutic potential for diseases in which IFN-gamma-producing cells are desired.The Journal of Immunology 11/2009; 183(11):7161-8. · 5.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: CD4+ regulatory T cells (Tregs) maintain immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses. The core genetic program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-dependent gene repression remains largely unknown. We identified Eos, a zinc-finger transcription factor of the Ikaros family, as a critical mediator of Foxp3-dependent gene silencing in Tregs. Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs. Silencing of Eos in Tregs abrogates their ability to suppress immune responses and endows them with partial effector function, thus demonstrating the critical role that Eos plays in Treg programming.Science 09/2009; 325(5944):1142-6. · 31.48 Impact Factor -
Article: Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells.
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ABSTRACT: Lymphocyte Activation Gene-3 (LAG-3) is a transmembrane protein that binds MHC class II, enhances regulatory T cell activity, and negatively regulates cellular proliferation, activation, and homeostasis of T cells. Programmed Death 1 (PD-1) also negatively regulates T cell function. LAG-3 and PD-1 are both transiently expressed on CD8 T cells that have been stimulated during acute activation. However, both LAG-3 and PD-1 remain on CD8 T cells at high levels after stimulation within tolerizing environments. Our previous data demonstrated that blockade of either LAG-3 or PD-1 using mAb therapy in combination with vaccination restores the function of tolerized Ag-specific CD8 T cells in models of self and tumor tolerance. It is unclear whether tolerized CD8 T cells coexpress PD-1 and LAG-3 or whether PD-1 and LAG-3 mark functionally distinct populations of CD8 T cells. In this study, we describe three populations of CD8 T cells activated under tolerizing conditions based on LAG-3 and PD-1 staining, each with distinct phenotypic and functional characteristics. From a mechanistic perspective, both Ag concentration and proinflammatory signals control the expression of LAG-3 and PD-1 phenotypes on CD8 T cells under activating and tolerizing conditions. These results imply that signaling through the PD-1 and LAG-3 pathways have distinct functional consequences to CD8 T cells under tolerizing conditions and manipulation of both Ag and cytokine signaling can influence CD8 tolerance through LAG-3 and PD-1.The Journal of Immunology 07/2009; 182(11):6659-69. · 5.36 Impact Factor -
Article: Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model.
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ABSTRACT: To study the immune response to prostate cancer, we developed an autochthonous animal model based on the transgenic adenocarcinoma of the mouse prostate (TRAMP) mouse in which spontaneously developing tumors express influenza hemagglutinin as a unique, tumor-associated antigen. Our prior studies in these animals showed immunologic tolerance to hemagglutinin, mirroring the clinical situation in patients with cancer who are generally nonresponsive to their disease. We used this physiologically relevant animal model to assess the immunomodulatory effects of cyclophosphamide when administered in combination with an allogeneic, cell-based granulocyte-macrophage colony-stimulating factor-secreting cancer immunotherapy. Through adoptive transfer of prostate/prostate cancer-specific CD8 T cells as well as through studies of the endogenous T-cell repertoire, we found that cyclophosphamide induced a marked augmentation of the antitumor immune response. This effect was strongly dependent on both the dose and the timing of cyclophosphamide administration. Mechanistic studies showed that immune augmentation by cyclophosphamide was associated with a transient depletion of regulatory T cells in the tumor draining lymph nodes but not in the peripheral circulation. Interestingly, we also noted effects on dendritic cell phenotype; low-dose cyclophosphamide was associated with increased expression of dendritic cell maturation markers. Taken together, these data clarify the dose, timing, and mechanism of action by which immunomodulatory cyclophosphamide can be translated to a clinical setting in a combinatorial cancer treatment strategy.Cancer Research 06/2009; 69(10):4309-18. · 9.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Tumors express a wide variety of both mutated and nonmutated Ags. Whether these tumor Ags are broadly recognized as self or foreign by the immune system is currently unclear. Using an autochthonous prostate cancer model in which hemagglutinin (HA) is specifically expressed in the tumor (ProHA x TRAMP mice), as well as an analogous model wherein HA is expressed in normal tissues as a model self-Ag (C3HA(high)), we examined the transcriptional profile of CD4 T cells undergoing Ag-specific division. Consistent with our previous data, transfer of Ag-specific CD4 T cells into C3HA(high) resulted in a functionally inactivated CD4 T cell profile. Conversely, adoptive transfer of an identical CD4 T cell population into ProHA x TRAMP mice resulted in the induction of a regulatory phenotype of the T cell (Treg) both at the transcriptional and functional level. Interestingly, this Treg skewing was a property of even early-stage tumors, suggesting Treg induction as an important tolerance mechanism during tumor development.The Journal of Immunology 05/2009; 182(8):4675-85. · 5.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Cancer immunotherapy refers to an array of strategies intended to treat progressive tumors by augmenting a patient's anti-tumor immune response. As immunotherapy is eventually incorporated into oncology treatment paradigms, it is important to understand how these therapies interact with established cancer treatments such as chemotherapy or Radiotherapy (RT). To address this, we utilized a well-established, autochthonous murine model of prostate cancer to test whether RT could augment (or diminish) the CD4 T cell response to a tumor vaccine. Transgenic mice that develop spontaneous prostate cancer (TRAMP) which also express a unique tumor associated antigen (Influenza hemagglutinin) under the control of a prostate-specific promoter were given local RT in combination with immunotherapy. The immunological outcome of this combinatorial strategy was assayed by monitoring the effector response of adoptively transferred, prostate-specific CD4 T cells. Neither RT nor immunotherapy alone was capable of priming an anti-tumor immune response in animals with evolving tumors. The combination of immunotherapy with RT resulted in anti-tumor T cell activation--this effect was profoundly dependent on the relative timing of RT and immunotherapy. Anti-tumor immune responses occurred when immunotherapy was administered 3-5 weeks post-RT, but such responses were undetectable when immunotherapy was administered either earlier (peri-radiotherapy) or later. The therapeutic temporal window of immunotherapy post-RT suggests that highly aggressive, immuno-suppressive tumors might be most sensitive to immunotherapy in a fairly narrow time window; these results should help to guide future development of clinical combinatorial strategies.The Prostate 10/2008; 68(12):1319-29. · 3.57 Impact Factor
Publication Stats
769 | Citations | |
203.48 | Total Impact Points | |
Top Journals
Johns Hopkins University
- • Department of Medicine
- • McKusick-Nathans Institute of Genetic Medicine
- • Department of Pathology
Baltimore, Maryland, United States
Bioinformatics Institute of India
Noida, Uttar Pradesh, India
St. Jude Children's Research Hospital
- Department of Immunology
Memphis, Tennessee, United States


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Ohio Official's Advisory Group Studies Police Training
The quality of police training academies in Ohio and the need for stronger statewide training standards are among the issues an attorney general's committee is considering as it explores possible changes to the way Ohio trains police officers.
Justices Will Hear Ohio's Gay Marriage Cases April 28
The Supreme Court will hear arguments over same-sex marriage on April 28.
Cleveland To Host 1st GOP Presidential Primary Debate
The head of the Republican National Committee says its first primary debate for the next presidential election will be in Cleveland.
Late Winter Storms Clips Columbus, Slams Southwest Ohio
Columbus saw very little snow Wednesday night and Thursday morning, but it was a much different scene in Chillicothe and areas further south.
OSU To Require Nearly All Freshmen To Be Fully Vaccinated
OSU says beginning in the fall, all first-year students who attend at least half-time with one on-campus course will have to be fully vaccinated.
Teacher Jailed For Showing High School Class Violent Movie
A former substitute teacher convicted of showing a movie including graphic sex and violence to a Columbus high school class has been sentenced to 90 days in jail.
DeWine's Advisory Group Studies Police Training
A group formed by state Attorney General Mike DeWine is continuing its study of possible changes to the way Ohio trains police officers.
Ohio Won't Withhold School Funding For Those Skipping Tests
Ohio's superintendent says the state won't withhold funding to penalize schools for students opting out of standardized tests this year.
Ohio Secretary Of State, Auditor To Testify At Statehouse
Two of Ohio's statewide officeholders are making appearances at the Statehouse on the same day to support separate business and charter school proposals.
Central Ohio To Get New 380 Area Code In Existing 614 Region
Central Ohioans will see a new 380 area code introduced because the available phone numbers for the existing 614 code are expected to run out next year.

subset: commoncrawl


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CAMRA Forth Valley is a regional branch belonging to the Campaign for Real Ale (CAMRA). CAMRA is an independant, voluntary, consumer organisation which campaigns for real ale, real pubs and consumer rights. CAMRA has over 164,000 members nationwide and 200 branches in the UK.
CAMRA is there to promote your love of real ale and new members are always welcome. In the Forth Valley Branch we manage to have a full social calendar and organise two successful real ale festivals a year. If you love beer and pubs and enjoy a full pint, CAMRA is the place for you!
Read what the papers have to say about CAMRA and CAMRA Members by clicking HERE.
There are several posts still vacant within the branch, although these are not necessarily Committee posts. Public Affairs Officer, Firkin Forth Valley Editor and Publicity Officer.
Any members who would be prepared to assist with any of these should contact the Chairman Bill Purnell or the Secretary Gordon Morrison
The The Woodside Hotel Stirling Road, Doune and Ballencreiff 31-45 Hopetoun Street, Bathgate are now selling Real Ale.
Latest pages updated - Home, Branch Diary, Events Close By, Festivals, Pubs
Webmaster - Ron Mennie
First award 2000
2014 little boy now grown up? |
We are always looking for like-minded people who are willing to give some of their time to help organise things like beer festivals or social nights. Why not come along to one of our monthly meetings and get involved?
And if you're a CAMRA member visiting from another area, please feel free to join our monthly meetings and enjoy a chat and beer.
Take a look at our branch diary to see when and where we meet...
The views expressed on this site are not necessarily those of the Campaign for Real Ale Ltd or Camra Forth Valley. Whilst every effort is made to ensure that the information on this site is accurate and up to date, no responsibility for errors and omissions can be accepted.


text:
Welcome, Sign In
Organization Gives 600 Backpacks Of School Supplies To Students
Description:Heading back to school means that students will need a lot of school supplies, but some families cannot afford to get their children what they need so the burden often times falls on the teachers. One organization aims to give students and teachers supplies. (2:34)
Source: Q13FOX
Tags: back to school , charity , school supplies , seattle schools


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Winter Store Hours
10:00 - 4:00
Monday, Tuesday, Friday, Saturday....closed Wednesday and Thursday beginning 1/28.
If school is closed, so are we!
January Sales & Clearance...
Over 300 bolts of fabric at just $6.95/yard...big selection of Christmas and children's fabrics...reduced panels and many kits reduced up to 50% off...new fabrics arriving and need to make room!
We have fabrics for Moda's "Piece and Comfort" Challenge...entry forms and information available. Quilt must be made from the collections "Red, White & Free" or "Because of the Brave." Cash prizes and proceeds from the challenge benefit USACares.org.
"Crazy for Red" from Moda is here...if you loved "Midwinter Red", you'll want this one too! Come see our sample using a jelly roll with a modern twist.
"Frozen"panel/book along with selected bolts are now available.
(Images of Cruise Quilts)
Quilters Quarters is excited to announce that we are sponsors of a quilting cruise February 22nd-March 1st, 2015. You will board Royal Caribbean's "Freedom of the Seas" leaving from Port Canaveral, FL. Get together with new and old quilting friends as you cruise through the stunning Eastern Caribbean. Non-quilters receive $200 off price. Quilting classes and workshops will be during the days at sea. Marilyn Foreman of "Quilt Moments" will be our featured teacher. Sewing machines are provided on board by Janome.
For further information go to:
Or to make reservations,call
Cruise Holidays at (888) 744-7397 or email at firstname.lastname@example.com.
"Pixie" from Arrow Cabinets
Open size- 59" x 36"...closed size-13" wide
Comes with cutting mat! Call for details or come in & see it!
We also have 3 other floor models on display for you to see....see "Dingo" model below....
The Notions Wall
"Dingo" Model K7905/7911
Pictures shown are of the largest Kangaroo Kabinet on display in the shop.
www.kangarookabinets.com or


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Town Square
Menlo-Atherton presents the hit musical GREASE!
Original post made by Drama Booster, Menlo-Atherton High School, on Mar 21, 2007
The show will premiere on Thursday, March 29 at 7 p.m., with repeat performances on Friday, March 30 at 7 p.m., Saturday, March 31 at 7 p.m., and Thursday, April 5 at 4:30 p.m. There will also be a special understudy matinee on Saturday, March 31 at 2 p.m.
Don't miss it! Get your tickets ($8 regular; $5 understudy matinee) by contacting April Paye at firstname.lastname@example.com or purchase tickets at the door. There will be a special treat for anyone who comes in a 50s costume! Come and see why we're the ones that you want!
Menlo-Atherton High School, 555 Middlefield Road, Atherton, J-Building.
Comments (1)
a resident of another community
on Apr 2, 2007 at 3:29 pm
We are not biased, of course, but thought that Amanda Tachis in the role of Sandy was even more compelling and artistic than Olivia Newton-John's performance in the film. Truthfully, we were enthralled by the whole performance of the cast, and extremely proud of Amanda. Tom and Rita, proud Grandparents.
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An Open Letter To A Southwest Flight Attendant
By Erin Glanville | 19 comments | 9,848 views
Cho's Los Altos finally opens
By Elena Kadvany | 21 comments | 4,405 views
College Touring Tips
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ZIZ article.
LEEWARD ISLANDS- Former West Indies all rounder Keith Lloyd Thomas Arthurton has been included in the Nevis Masters' Cricket squad for the upcoming annual Leeward Islands Masters' tournament which is set to bowl off on Thursday 16th May in St. Kitts.
WICB Media Release.
ST. JOHN'S, Antigua – Windward Islands duo Devon Smith and Shane Shillingford again featured prominently on the list of award winners for the Regional 4-Day Tournament, which ended last Saturday in Barbados.
By CMC.
LONDON, England - West Indies opening batsman, Kieran Powell, has sealed a deal with the exclusive Pinneys Plantation Resort in Nevis.
CAVE HILL, Barbados – The West Indies Cricket Board advised on Tuesday that 14 players have been chosen for the Sagicor West Indies High Performance Centre for the 2013-2014 programme.
This Is Derbyshire article.
DERBYSHIRE, ENGLAND - Granted a favour by the weather for once, Sandiacre Town showed all the ruthlessness that made them Beechwood MG Derbyshire Premier League Champions last season as they crushed Matlock at Causeway Lane.


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The Briars can make your wedding dreams come true. Our heritage resort on the shores of Lake Simcoe - about 5 hours from Detroit - has hosted memorable wedding weekends for decades.
We are a full service travel agency with over 100 years of collective experience. We are happy to assist you with all your vacations planning for family getaways, honeymoons and anniversaries and weddings. Our agents have multi-specializations to cater to all your dreams


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Via Padova 6, 47841 Cattolica, Italy – Show map
Staff cordiale e professionale. La stanza è spaziosa pulita con una vista mozzafiato. Bella la piscina esterna. The Staff was friendly and professional. The room spacious and clean with a breathtaking view. The outdoor swiming pool was truly nice.
We were staying 5 nights with our 3 year old son. Everything was perfect! Great hotel, service and food! Will be back for sure.
Расположен на первой линии,большой балкон с видом на море,хорошие завтраки,всегда были фрукты.наличие подземного паркинга.Ежедневная уборка,часто меняли полотенца.Наличие в отеле пляжных полотенец бесплатно!
Posizione vista mare e personale gentile.
la colazione e la vicinanza al mare
posizione, pulizia, cordialità, piscina, colazione
Ottimo cibo e camere ampie e con vista mare splendida
Posizione comoda alla spiaggia, grandezza delle camere e la pulizia .Ottima colazione
la camera discreta, la cucina del ristorante, l'accoglienza.
Proximité de la mer et des boutiques
Right on Cattolica's beachfront, Hotel Caravelle has underwent complete renovation in 2008. Enjoy great facilities including a spa center and outdoor pool in a quiet but central part of town.
Just a 5 minute walk from shops, restaurants, bars and clubs and 550 yards from the very center of Cattolica you will also find entertainment on site. Relax in Hotel Caravelle's newly-refurbished pool with its solarium or enjoy Jacuzzis, massages or beauty treatments. The kids will enjoy the beach mini-club and their own play area and evening entertainment is also organized by the seaside.
Dine at the Caravelle's seafront restaurant with its lovely views, enjoying an excellent choice of menu, including vegetarian options and dessert buffets.
Bus and train connections are just a few steps from your hotel and the Caravelle can also organize tours to San Marino, Urbino and Venice for you.
Hotel Rooms: 51 This property has been on Booking.com since Mar 18, 2010.
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41 verified reviews
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They speak your language!
Hotel Caravelle's staff speaks: Italian
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Outdoor Pool (seasonal)
Ping-Pong, Beachfront, Bikes Available (free), Kids' Club
Food & Drink
Bar, Breakfast in the Room, Restaurant with Dining Menu
WiFi is available in public areas and is free of charge.
Private parking is available on site (reservation is not needed) and costs EUR 8 per day.
Room Service, Packed Lunches, 24-Hour Front Desk, Shared Lounge/TV Area, Laundry
Newspapers, Safe, Non-smoking Rooms, Family Rooms, Elevator, Air Conditioning
Until 10:00 AM
Cancellation and prepayment policies vary according to room type. Please enter the dates of your stay and check what conditions apply to your preferred room.
Children and Extra Beds
All children are welcome.
All children under 3 years stay free of charge when using existing beds.
All children under 2 years are charged EUR 15 per person per night in a crib.
All older children or adults are charged EUR 40 per person per night for extra beds.
The maximum number of extra beds/cribs in a room is 3.
Any type of extra bed or crib is upon request and needs to be confirmed by management.
Additional fees are not calculated automatically in the total cost and will have to be paid for separately during your stay.
Pets are allowed on request. No extra charges.
Cards accepted at this property
Hover over the cards for more info.
Other Places you Might Like
Based on 41 reviews
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Hotel San Marco is in the heart of Cattolica, 65 ft from the sandy beach and Piazza 1 Maggio square. Its rooftop terrace with swimming pool and hot tub offers views of the Adriatic Sea.
Score from 59 reviews
Featuring a seafront location and a rooftop pool with panoramic views, the Golden Tulip Hotel Waldorf is in the Marina Centro area of Rimini. It features a traditional restaurant and free parking.
Score from 423 reviews
Very good
Just 250 metres from the beach, Erbavoglio Hotel is a 15-minute walk from the centre of Rimini. This property offers a free outdoor hot tub and wellness centre, plus rooms with a balcony.
Score from 964 reviews
Relais La Loggia is set within the ancient walls of the Gradara Castle and offers beautiful views from its panoramic terrace. The same family has managed the hotel for the past 50 years.
Score from 35 reviews
Pool was nice but the added activity areas such as the table tennis table and mini bouncy castle were broken and not functioning well if at all. Ashtrays not cleaned for days; Waiting staff in dining room very nice and attentive. Night staff very helpful and well-mannered. Breakfast not bad but certainly not 4 star. Cooked eggs on request only and I challenge anyone to find a difference between the scrambled eggs and the omlette!!!???
Room: very average comfort; cheap twin bed only which kept separating when a double "letto matrimonial" was specifically requested; not enough and no extra pillows available; minibar advertised was non existent, water only which was charged (normally initial set is at least a gratis welcome for a so-called 4 star hotel); cleaning average and outdoor terrace not done at all during our entire 5 day stay; bathroom products dreadfully cheap and insufficient, standard lucky to be 2 star standard; bathroom furnishings impossibly small to store anything like personal toiletries other than on the floor, no cupboard or drawer spaces; no glasses only extremely cheep plastic cups that were mostly broken; bedroom furniture outdated and insufficient for a family; tips for waiting staff not distributed; Pool area: added activity areas such as the table tennis table and mini bouncy castle were broken and not functioning well if at all. Ashtrays not cleaned for days; be careful to check all extra daily costs including parking and beach! Parking available but don't take a big car - very cramped spaces! Front desk receptionist abrupt and officious. I am not a fussy traveller and have stayed in many different locations throughout the world however I would like to know the criteria for this hotel to be registered as a 4-star as it would be lucky to make a 2 star rating. First real european beach holiday away together, very disappointing.
Staff cordiale e professionale. La stanza è spaziosa pulita con una vista mozzafiato. Bella la piscina esterna. The Staff was friendly and professional. The room spacious and clean with a breathtaking view. The outdoor swiming pool was truly nice.
L'esterno dell'edificio è fatiscente. Mancano i dettagli che normalmente ti aspetti da un 4 stelle. The exterior of the building is a bit crumbling. Details that you normally expect from a 4 stars hotel are missing.
We were staying 5 nights with our 3 year old son. Everything was perfect! Great hotel, service and food! Will be back for sure.
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text: http://askubuntu.com – I am using Ubuntu 12.10 on my HP G7 laptop with a dual monitor setup. I have the laptop monitor & the other display is a 36" Sanyo HDTV. I cannot change the resolution on the 36" using the compizconfig tool OR the display tool under settings. If I set the resolution to anything except 1280x720 on this monitor, it goes dead and I get "no signal". I have looked & looked but cant find an answer to this! (HowTos)


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Six Flags Discovery Kingdom Discount Tickets for 2015. Six Flags Discovery Kingdom discount passes have just been updated, so the current deal gets you tickets for only $39, a savings of $25 on single day "any day" … [Read more...]
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Bay Area Discovery Museum
The Bay Area Discovery Museum deal has just been updated. The museum runs these occasional daily deals like the one below, with prices starting at $15 for two admission tickets. So if you know you're looking for a fun … [Read more...]
Napa/Sonoma Wine Tasting Daily Deals
Some of the best prices for wine tasting in the Napa and Sonoma Valleys can be found on the daily deals sites like Groupon. Before you head out, check the offers for those areas because they may not show up in your local … [Read more...]
Petaluma Butter & Egg Days Parade
Not every town can boast a Butter & Egg Day Parade, and folks in Petaluma have good reason to love theirs. The annual Petaluma Butter & Egg Days Parade and Celebration is getting ready to roll (April 25, … [Read more...]
Napa Valley Bike Tour
Of all the beautiful cycling tours in the Bay Area, these Wine Country tours are among the most popular. The emphasis here is on wine country and beauty rather than hardcore cycling, so don't worry if you're not fit for … [Read more...]
Bay Area Paintball Deal
Ready, aim, fire! The paintball deals are back in the Bay area, at unbeatable prices. Take your pick of six SF Bay Area locations. This deal is yours to use any day up to the expiration date listed by the deal sources. … [Read more...]
Sonoma Lavender Festival
Find out everything you ever wanted to know about lavender ... and then some. The Sonoma Lavender Festival (June 27 - 28, 2015) isn't a free festival, but the event offers plenty of free fun once you're in, like … [Read more...]
Wine Country Hot Air Balloon
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The Marine Mammal Center in Sausalito is not only a great side-trip for San Francisco visitors, it's a popular layover for sick and injured sea lions, along with those who just need a little R&R. Animal lovers of all … [Read more...]
Somona Valley's Russian River by Canoe
Here's a great way to tour Sonoma Valley for the day -- paddle down the Russian River in an inflatable canoe. Take the family, take the dog, or just take it easy and roll down the river with your feet up over the tubes … [Read more...]
Charles Schulz Museum
The Charles M. Schulz Museum in Santa Rosa, features exhibits and programs that highlight the life and art of the beloved cartoonist and international icon Charles M. Schulz (1922-2000), creator of the Peanuts … [Read more...]
Side Trip: Point Reyes CA
Point Reyes National Seashore, in West Marin, provides SF Bay area hikers, bicyclers, and horseback riders with some of the best views around: waves crashing against rocky headlands, fern-laden canyons, open grasslands, … [Read more...]
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A great way to keep a few more pennies in your pocket is to pack a picnic lunch and head out to wine country. You don't need to spend lots of money in fancy restaurants to enjoy great food in a romantic Napa Valley … [Read more...]


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Synonyms of drum in English:
Back to topPhrases
- 1
drum someone out
- he was drummed out of officedrive out of, get rid of, thrust out of, push out of;Military cashierinformal give someone the boot, boot out, kick out, give someone their marching orders, give someone the bullet, give someone the push, show someone the door, send packing
Word links
, , player of drums
Definition of drum in:
- British & World English dictionary
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- US English synonyms
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Working At Your Desk Just Got Easier.
Have you ever looked at your desk and took a long, deep sigh because all you can see is mounds and mounds of stuff?
You didn't mean to have your desk end up looking this way…it just kind of…happened.
You could ignore the problem, but then you'd still be sorting your way through papers, files and supplies…
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Breeze through tasks on your to-do list.
Find your favorite red stapler when you need it.
Focus on your financial spreadsheets and have a professional-looking workspace that is the envy of your coworkers.
In 8 Essential Tips to Organizing the Top of Your Desk, I'll show you how to give your desk the hearty detox it deserves.
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Enter your name and email address below for instant access to the FREE eBook.
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Summer Fest: 6 Ways to Cook With Plums
by Allison Milam in In Season, July 18, 2012There are more uses for the juicy plum than eating around the pit and nose-crinkling when a prune comes into view. People love plums, of course, but they haven't reached the status of the heavy hitters: the oranges, apples and bananas. Even when it comes to antioxidants, that pesky pomegranate gets all of the attention. However, like many of our favorites, this stone fruit has some serious culinary chops, especially when they're in season and literally overflowing with ambrosial juices. Not to mention, this purplish-red beauty is brimming with nourishment and health benefits. It's about time we rethink the perks of the plum, people.
If there's anything we value in the kitchen, it is versatility. Try one of these spins on the fresh, in-season plum:
Grill It
There's something about cutting a ripe plum in half, clawing out the core and then getting it on the grill. It needs nothing more than some heat and maybe a brush of olive oil for the flesh to soften and caramelize and for a nice char to build up. It's as simple as that. After grilling, drizzle plums with a balsamic and black pepper syrup, bring in some brown sugar or stick them on a skewer. And the plum doesn't need to go it alone; combine it with other stone fruits for a grilled treat.
Puree It
Blend plums with a few apples, cinnamon sticks, apple juice, sugar and for a killer (not to mention beautifully-colored) plum applesauce (pictured above).
Drink It
Orange juice. Apple juice. Lemonade. But what about plum drinks? No, we're not talking prune juice. Slurp down Bobby's Plum Prosecco Cocktail, which is laced with honey, bubbles and, of course, plum.
Sweeten It
Plums are as sweet as sugar. But when dessert rolls around, sometimes you need a bit more than a slice of fruit. Alton Brown's Honey Plums add sweet to sweet by cooking under-ripe plums in honey until soft but not cloyingly sweet.
Cook It
Believe it or not, plums — both dried and fresh — work well with their fair share of proteins. For a meal with sweet-and-sour flavors, go for Apricot Glazed Chicken With Dried Plums and Sage; it has a shot of vinegar offsetting the sweetness of the dried plums. More of a pork person? Rachael Ray's pork tenderloin shines with her plum barbecue sauce. Instead of getting her plum sauce from the jar, she uses fresh plums and the essences of ginger, five-spice powder and hoisin sauce.
Bake It
As a fruit, the plum does wonders when it meets a little butter, sugar, flour and egg. Take it from Ellie Krieger; her Plum Tart With Almond Pastry Crust centers around the purple fruit, which she poaches, skins and then bakes into an almond crust. Into crisp? Try Food Network Magazine's Plum Apricot Crisp, and go heavy on those plums.
Tell us: Do you cook with plums?
Ingredients, Inc.: Pork, Plums and Rosemary Kabobs
Virtually Homemade: Grilled Plum Pizza With Goat Cheese
Cooking Channel: Best Plum Dessert Recipes
BGSK: Grandma Esther's Plum and Walnut Cake
Delicious Lean: Plum Delicious Pork Chops
Daily*Dishin: Roasted Chicken With Plum Chili Salsa
Napa Farmhouse 1885: Time for Plum Cobbler?
Thursday Night Dinner: Plum BBQ Chicken
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And Love It Too: Plum Pickin' Pineapple Jam
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A man is at his lawyer's funeral and and is surprised by the turnout for this one man. He turns to the people around him. "Why are you all at this man's funeral?" A man turns towards him and says, "We're all clients." "And you ALL came to pay your respects? How touching." "No, we came to make sure he was dead."
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Jun 27, 2011 GMT
Pastebin services like Ubuntu Pastebin are handy for sharing text and code snippets with a minimum of fuss. And if you happen to use Tomboy as your tool of choice for storing and organizing scribbles and code snippets, you'll appreciate the PasteBinIt addin which lets you publish any Tomboy note on Ubuntu Pastebin. To install the addin, grab its latest version from the project's website, and move the downloaded PasteBinIt.dll file to the ~/.config/tomboy/addins/ directory. In the Tomboy, choose Edit | Preferences | Add-ins and enable the PasteBinIt addin under the Tools section. To publish the currently opened note, press the Tools button and choose the Paste Bin it! command.Via OMG!Ubuntu!Productivity Sauce
Jun 22, 2011 GMT
The Google Web Fonts repository is a real treasure trove for anyone looking for high-quality open source fonts, but finding the font you like among dozens of available typefaces can be a time-consuming task. Fortunately, there is a nifty tool that can help you to quickly preview the fonts available in the repository -- provided you use Google Chrome or Chromium as your browser of choice. Using he Google Font Previewer extension, you can access all Google web fonts with a single mouse click. What's more, when you select a font, it's automatically applied to the currently viewed web page, so you immediately see what the font looks like in a real-world situation. ...Jun 21, 2011 GMT
If you follow Linux-related news, you've probably heard about SparkleShare, a promising open source alternative to the popular Dropbox service. SparkleShare has been under active development for some time, but the latest 0.2.2 release is actually the first version suitable for practical use. Mind you, it's far from ready for production use, so install it only if you want to satisfy your curiosity, or if you enjoy using bleeding edge releases.While you can find .deb SparkShare packages in the wild, your best bet is to compile the software from source. This is a rather straightforward thing to do. First off, you need to install the required dependencies. On Ubuntu, this can be done by...Jun 16, 2011 GMT
Since Autokey supports Python, you can automate virtually any task using simple (or complex) scripts. A recent addition to my ever-growing collection of handy Autokey scripts is a relatively simple solution for saving text selections as Tomboy notes: import sys, dbus, gobject, dbus.glib snippet = clipboard.get_selection() retCode, title = dialog.input_dialog("Note Title", "Enter note title:") bus = dbus.SessionBus() obj = bus.get_object("org.gnome.Tomboy", "/org/gnome/Tomboy/RemoteControl") tomboy = dbus.Interface(obj, "org.gnome.Tomboy.RemoteControl") newnote=tomboy.CreateNamedNote(title) tomboy.SetNoteContents(newnote, ...Jun 09, 2011 GMT
There are plenty of powerful open source web-based applications for sharing photos out there. But if you need to publish a bunch of photos on the web as a simple static HTML gallery without all the bells and whistles, a command-line tool like llgal can come in rather handy. This little tool is available in the software repositories of many popular Linux distributions, so you can install it in a pinch. Using llgal to generate an HTML gallery couldn't be easier: in the terminal, switch to a folder containing photos, and run the llgal command. This creates a gallery using default settings. However, llgal supports a handful of options you can use to tweak its behavior and the resulting...Jun 06, 2011 GMT
It's not immediately apparent how exactly the drag2up extension works and what it actually does: once installed, it doesn't add any new buttons or menu entires. But the extension doesn't need to expose itself, because it does its job in the background. And its job is a pretty simple one: when you drag a document, a file, or an image from your desktop onto a form field on a web page, the extension automatically uploads the item to one of the supported services. Not sure how this can be useful? Say you want to share a photo using the Identi.ca microblogging service. Simply drag the photo you want onto the status update field on Identi'ca's...May 31, 2011 GMT
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Buy this issue as a PDF
Old Vulnerabilities Are Kept Alive Through Bad Configuration
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Crash victim's family: We want our day in court
UPDATED 7:43 AM EST Dec 04, 2013A Baltimore family told the city's top prosecutor they just want their day in court after learning a plea deal is in the works for a man accused of speeding through downtown and killing their loved one in front of City Hall earlier this year. George Lettis has more from Matt Hersl's family.
Video TranscriptARE CONSIDERED NON-LIFE- THREATENING. THERE'S NO WORD YET ON WHETHER THE DRIVER REMAINED AT THE SCENE. WE JUST WANT OUR DAY AT COURT. THAT IS THE MESSAGE FROM A FAMILY FOR THE TOP PROSECUTOR TONIGHT. THEY LEARNED THAT A PLEA DEAL IS IN THE WORKS FOR A MAN ACCUSED OF SPEEDING DOWNTOWN AND KILLING THEIR LOVED ONE IN FRONT OF CITY HALL. AND HAPPENED EARLIER THIS YEAR. THE FAMILY OF MATT HERSL THANKS -- THANKS -- THINKS THE EVIDENCE AGAINST THE DRIVER IS OVERWHELMING. AND YESTERDAY, THEY GOT A SURPRISE CALL. WE JUST WANT TO HEAR THE TRUTH. WHAT HAPPENED THAT DAY. IN THE SAME SPOT WHERE MATT HERSL WAS KILLED BY A SPEEDING CAR ON APRIL 9, HIS FAMILY AND FRIENDS ON TUESDAY ONE OF THE PUBLIC TO KNOW WHAT THEY THINK IS GOING ON BEHIND THE EASE WITH THE CASE. BUT THINGS ARE BEING SWEPT UNDER THE RUG. MATT HERSL' FAMILY GOT A CALL YESTERDAY THAT WITHOUT EXPLANATION AND AGAINST THEIR PRIOR WISHES, THE PROSECUTION WILL PURSUE A PLEA BARGAIN AGAINST JOHNNY JOHNSON, THE MAN WHO WAS CHARGED WITH THE HIT -- VEHICULAR MANSLAUGHTER HE HAD A LENGTHY CRIMINAL RECORD, INCLUDING ARRESTS FOR ARMED ROBBERY, AND DRUG POSSESSION. HE HAD DRUGS IN HIS SYSTEM ALLEGEDLY. A STATE TROOPER FOLLOWED JOHNSON AS HE EXITED INTO DOWNTOWN BALTIMORE, RAN A RED LIGHT, AND CRASHED INTO A LIGHT POST AND MATT HERSL. THESE CRIMINAL OFFENDERS KEEP GETTING OUT ON PLEA BARGAINS. IT DOES NOT ACCOMPLISH ANYTHING. INVESTIGATORS HAVE TALKED TO AT LEAST A DOZEN WITNESSES. SOME OF THEM HELD JOHNSON ON THE GROUND WHEN HE TRIED TO RUN AWAY. WE WOULD LIKE OUR DAY IN COURT WE FEEL THAT THE CASE IS . CUT AND DRY. FROM THE PROSECUTION'S PLEA DEAL TO ITS CONDUCT, THE FAMILY IS UPSET WITH THESE XEROX PHOTOS THAT THE PROSECUTION GAVE THEM. THEY HAVE ASKED FOR CLEAR PHOTOS, BUT THEY HAVE BEEN IGNORED. OUR FAMILY BELIEVES THAT A LOT OF THINGS HAVE BEEN HELD BACK. THEY HAVE NOT BEEN BROUGHT FORTH. WE ARE VERY UPSET. THIS AFTERNOON, THE CITY'S ATTORNEY GAVE A STATEMENT THAT SAID IN PART, OUR DUTY IS TO PURSUE JUSTICE BY MOUNTING A THOROUGH INVESTIGATION AND THE -- AGGRESSIVE PROSECUTION. JUSTICE REQUIRES ME TO REFRAIN FROM COMMENTING ON PENDING CASES. MY THOUGHTS ARE WITH HIS FAMILY. A HEARING ON THIS CASE IS SETTLED FOR DECEMBER 12.
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Summerlicious is a collaboration project of 4 designers from different stores and comes in beautiful fresh, fruity and vibrant colors. It's perfect for all your general summer layouts that are not beach or vacation related. AADesigns, ManuScraps, NBK Design and Studio Romy bring you 4 coordinating kits for a wonderful low price in this bundle!
This is the elements pack by Manu Scraps Contains 45 elements like peonies, rose, orange, peach, lemons, berries, water melon, ice cream, ribbons, frames, foliage, grass hopper, butterfly, ladybug, cocktail, bird, paper umbrellas und more!
Created and saved at 300 dpi Full size License Includes: Personal Use, Scrap for Hire, Scrap for Others friendly. PU S4H S4O
Product 362/432


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From side-splitting laughs and humorous vignettes to poignant moments of emotional authenticity, reality show collides with standup comedy in "Standup Guys." Comedic veterans Kenn Kington, Daren Streblow and Robert G. Lee take the stage as they reveal a behind-the-scenes look at standup comedy. Ticket prices and ordering information can be found below the following video: For info contact: 262-544-6000 |
PRICE DEADLINE : (EST Applies) | DAY OF | |||||||||||
Artist Circle ticket holders will have early access to the show along with a Q&A and M&G starting at 6 pm. | ||||||||||||
Artist Circle | $17.00 | |||||||||||
General Admission | $11.00 |


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Reviews for Love's Honor |
ultimatebishoujo21 chapter 1 . 10/6/2008 cool story |
moviefan-92 chapter 17 . 6/12/2008 B-e-a-utiful. I always was a Utena X Touga shipper. It was indeed an excellent story. In fact, if you change the names of the characters and tweek the plot, I could see this becoming an original story that could get published. |
momoiiey chapter 4 . 12/26/2007 GREAT SO FAR. ITS REALLY LONG AND VERY INTERESTING. YOU COMBINED ALL THREE AND ITS GOING PERFECTLY. EVERYONE ELSE HAD TROUBLE DOING JUST TWO BUT THIS ONE IS REALLY GOOD. THANKS |
momoiiey chapter 1 . 12/25/2007 GREAT CHAPTER. THANKS |
hitherehowareyou chapter 1 . 12/20/2005 This is so gud! I'm only the first chapter, but its REALLY god! Akkirako Chikuro |
Kay D. Chan chapter 1 . 9/3/2005 Just coming back to an old favorite. It'll be a different experience being able to read the whole story through if I wanted rather than waiting for an update, but so far, it's still just as good as I remember. |
Saionji's Rose Bride chapter 17 . 6/19/2005 Congratulations! Your fanfic has been selected to be in the Utena Best of Fanfiction C2 Community. It has been chosen because of its quality and or originality in the section of its type. Please feel free to visit the C2 Community in this section. Thanks! Saionji's Rose Bride C2 Staff |
kara chapter 17 . 5/3/2004 OMG! This is one of the best fic's I have ever read! I was hooked from the start. Your descriptions are wonderful and I love the plot! I hope that you do write a sequel!_ |
Strawberry Demons chapter 1 . 4/30/2004 Only on the prelude but I love it. |
animelover17 chapter 1 . 2/16/2004 I love your fic! I've read it about 2 times now and it is really really good. You should write more like it! I cant wait! |
J. Merritt chapter 17 . 12/16/2003 I LOVED IT! This is by far one of the best fanfics I've read in a long time and THE best Utena fanfic I've EVER read! You did a great job of keeping the Utena cast in character and yet changing them enough to fit into your wonderful story. The plot was exciting and paced well. And I'm SO glad you let Utena and Touga end up together in the end! Excellent story and I can't wait for your next one. |
Ann A.K.A. Hitomi chapter 17 . 8/28/2003 Amazing! This is absolutely the best Utena/Touga fic I've ever read! I hope that you keep on writing fanfics in this awsome world you've created! |
DarkElf chapter 1 . 6/29/2003 I LOVED IT! :) Please write many many many more Utena?Touga fics! there are so few well written ones out there. |
Pseudonym Sylphmuse chapter 17 . 4/5/2003 I read this story a year ago and now that I have an account here at .net I'd like to say that is one of most well written Utena stories I've ever read. The characters' personalities are flawless and believable. And it is a good medieval fic as well. I'm adding this story to my favorite stories list. |
Amethyst edges chapter 17 . 11/9/2002 A friend of mine asked me to read your fic because she kept on describing it amazing. When I did read your work, I said to myself, wow...I love your deep words... |


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Dr. Sheila C. Harmeling, MD
- 59 Cavalier Blvd Ste 330
Florence, KY 41042 - 1 Location
- (859) 371-3232
Dr. Sheila C. Harmeling graduated from the University of Kentucky College of Medicine in 1992. She works in Florence, KY and specializes in Pediatrics and Adolescent Medicine. Dr. Harmeling is affiliated with Saint Elizabeth Healthcare.
Gender: Female
Languages Spoken: English
Pediatrics, Adolescent Medicine
Medical School: University of Kentucky College of Medicine; Graduated 1992


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Find Rooms
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per nightGold and Platinum iPrefer members receive a bottle of champagne when booking here or through iPrefer.com.
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Lienz in Osttirol, AustriaAccommodations
Grandhotel Lienz offers luxury accommodations in Lienz. These welcoming guestrooms all come standard with great views, intriguing design, generously-sized baths, and snack plates.


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Case Study: DownUnder GeoSolutions speeds up oil and gas exploration with an Intel® Xeon® processor E5-2600 v2 product family-based HPC platform.
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HSA lowers fees for medical devices brought in under Sar scheme
Published on Aug 2, 2012 12:41 PM
Doctors and medical device importers will pay lower fees for medical devices brought in under the Special Authorisation Routes (Sar) from this month.
The Health Sciences Authority (HSA) announced today that the cost of bringing in medical device for a patient under Sar will be lowered from the existing $500 to between $150 and $350.
Sar allows licensed importers and health-care professionals to import unregistered medical devices where there is a lack of registered alternatives. Under this scheme, importers can also import such devices for re-export, or to import them for research and training.
The revised fees are part of the enhancements to the medical device regulatory framework announced earlier this year, said HSA in a press release.
To continue reading, log in if you are a subscriber
If you are not a subscriber, you can get instant, unlimited access here


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New to Typophile? Accounts are free, and easy to set up.
I'll start with two apologies:
1. I'm certain this topic has been discussed frequently, but I had no luck searching within the forum.
2. My lack of knowledge about this subject makes it virtually impossible for me to be very specific, so I would just like some general estimates/guesses in response to my inadequate question.
I am setting a book using InDesign. My client is undecided about self-publishing or using a publishing company. (My client has several agents who are interested in handling the book.) I need to get a rough estimate of how much it would cost to print a professional quality paperback book in standard format, (about 5"x8"), approximately 300 pages in length, with back and front cover in color. My question involves only printing production costs for 1000 copies. Artwork and typesetting will be provided by yours truly.
I fully realize that my lack of details will result in less-than-happy responses, but all I need is a very rough approximation!
Thanks Much!
A couple of thou', either euros or dollars. Rough enough?
The design itself should come to, well, no more than a few hundred dollars -- an hourly rate is fair if you know your way around InDesign.
Biggest part of the printing costs is setting up and get started; only with more than 300 or 400 copies, time and paper are going to kick in. Binding sheets into real books is mostly a flat fee, though.
Why not ask a quotation from one or more printers in your neighbourhood? They are a friendly lot, and when given the opportunity, they will tell you what to ask next time.
Thanks Theunis de Jong-
Unfortunately, there's not a single printer in my neighborhood that I trust. (Nor are they friendly!)
Any other figures to throw at me, folks?
A couple places come to mind you may want to check out:
Lightning Source
Only 1000 copies is a pretty short run. Your best bet will probably be digital print-on-demand, as Chris links above.
Another to consider would be BookMobile.
Actually, book printers do a lot of runs of 1000 and less. Very few books sell in the multi thousands. I find Theunis' price estimate may be a bit low.
A Canadian company that specializes in books (yearbooks, history texts, etc.) is http://www.friesens.com/. They would be willing to provide a more complete quote.
I find Theunis' price estimate may be a bit low.
Ah, right. That would come out to a production cost of about $2.00 per 300 page book -- a bit on the low side. I'd change that to an estimate of $5 to $8 per book, retailing for something inbetween $50 and $80.
I don't think a 1,000 copy run can be done with Printing-on-Demand for that price.
chris said:
> A couple places come to mind you may want to check out:
> Lulu
> Lightning Source
um, lightning source, yes. lulu, no. i love lulu, but
you use lulu for one-offs, not a run of 1000 copies.
you should also consider _distribution_. unless you
actually _want_ to handle the distribution, or unless
all the books are going to just a handful of locations,
it might be good to go with a printer (like lightning,
or createspace) which is willing to handle fulfillment.
Thanks One and All-
Good information, as usual!
Sorry about being slow to respond... I was off doing something nefarious for a couple of weeks!


text:
Industry representatives demonstrated smoking equipment and marijuana plant growing systems. Some even gave business advice about what supporters hope will be a successful industry. But the drug itself was not on display at the show. It is still a violation of federal law to possess marijuana.
A closely watched case before the Supreme Court could have major results for religious rights in the workplace. It involves the clothing stores Abercrombie & Fitch and a young Muslim woman. She wore a Muslim headcovering, called a hijab, when seeking employment with the company.
See how well you understand the Health and Lifestyles story by taking a short quiz.
A former Muslim created a support group for others in the US and Canada who have left the faith. He wants former Muslims to meet, talk about their experiences and know that nothing is wrong with the decision to leave their religion -- some say it is a crime that can be punished by death.
American philanthropists gave more money to charitable causes in 2014 than the year before. The journal Chronicle of Philanthropy says that the top 50 donors from the U.S. gave a total of $9.8 billion. Many donations came from entrepreneurs who made their money in technology.
On Monday, a U.S. federal judge in Texas temporarily blocked President Obama's executive order on immigration. The order would protect up to 5 million undocumented immigrants from being sent back to their home country. Twenty-six states argued Mr. Obama overstepped his powers as president.
See how well you understand the story on charitable giving by taking a short quiz.
The three young people were all born in the 1990s. A woman who taught all three says they gave more in their short lives than many give in a full lifetime. She says the young people did whatever they could to help others. The suspected gunman is in jail. Police continue to investigate the shooting.
Americans honor the first president, George Washington, in February. The U.S. government calls George Washington's Birthday is not really his birthday. Some states consider the holiday a time to remember other presidents, too. How much do you know about American leaders?
Prisoners in California are learning how to write programs for computers -- an activity known as computer coding. It is a skill that many employers are seeking in new workers. Computer coding is now being taught at San Quentin State Prison, just north of San Francisco. The class began last year.
There is a growing trend in America towards more healthy food. People are visiting more "fast casual" restaurants and less fast food ones. Meanwhile, McDonalds earnings continue to decline. Observers say Americans want more choices and fresh food when choosing where and what to eat.
On Tuesday evening, a man shot and killed three Muslim students in North Carolina. Many American Muslims said the students' deaths did not get widespread news coverage because of their Islamic religious beliefs. Police officials continued to investigate the possibility of a hate crime .
Frank Lloyd Wright is called the father of American modern architecture. He created most of his works from 1900 to the 1950s, but his open-living spaces and imaginative designs still appear very modern. Last week, the United States nominated 10 of his buildings for the UNESCO World Heritage List.
Thomas Jefferson sold thousands of his books to the Library of Congress to replace books destroyed during the War of 1812; his collection includes the Koran in English and books on philosophy, mathematics, physics and agriculture. The collection is the centerpiece of the Library of Congress
Measles has become a public health issue in the United States. Measles cases were first reported last month at Disneyland in California. Since then, the disease has spread to more than 100 people across the country. And everyone has an opinion including parents and politicians.
Republicans now control a large majority of America's state and national offices -- including most of the governor's offices, state legislatures and the US Congress. The reasons: white voters leaving the Democrats and Republicans focus on winning at state and local level.
See how well you understand the news story by taking a short quiz.
Of the four trillion dollars requested in his budget, President Obama proposes to spend more than $50 billion on diplomatic and aid efforts around the world. That amount represents about 10 percent of what has been suggested for the U.S. Department of Defense.
Tsunamis are unexpected huge ocean waves. Earthquakes are often the cause of tsunamis. And that can interfere with escape. One coastal town in Washington State is copying a method used in Japan to survive tsunamis. Westport, Washington, is building the first U.S. vertical tsunami shelter.
Ambassador Mark Lippert is said to be in stable condition after a man in Seoul stabbed him. Ambassador Lippert was left with 80 stitches in his face. In other news, Liberia has released its last confirmed Ebola patient. The World Health Organization said Liberia reported no new cases last week. More
This weekend, President Barack Obama will visit Selma, Alabama, to mark the 50th anniversary of a day known as "Bloody Sunday." On March 7, 1965, police officers brutally attacked peaceful demonstrators in Selma. The protesters were part of a campaign to get voting rights for African-Americans. More
Few people believe the person who ordered Mr. Nemtsov's killing will be revealed. He joins a growing list of critics of Russia under President Vladimir Putin's leadership who many say have been killed for their work. Mr. Nemtsov was buried Tuesday after being shot and killed in Moscow days earlier. More
A coal mine exploded early Wednesday in the rebel-held city of Donetsk. Also in the news, the US Justice Department released its Ferguson police department report; China has announced it will increase its military spending by 10 percent; and Mexico captured a Zetas drug leader. More
Most people in developed countries do not have a problem getting prescription eyeglasses. They go to an ophthalmologist -- a trained specialist who treats problems and diseases of the eye. But in poor countries like Rwanda, it may take a lot more time, effort and money. More
Industry representatives demonstrated smoking equipment and marijuana plant growing systems. Some even gave business advice about what supporters hope will be a successful industry. But the drug itself was not on display at the show. It is still a violation of federal law to possess marijuana. More
Mitochondrial Replacement Therapy uses the genetic material from three people to create babies. The stated purpose of the therapy is to help mothers avoid passing genetic mutations to their babies. Some say MRT will lead to 'designer babies.' Others say it is dangerous, immoral or just wrong. More
Most scientists agree that increasing amounts of carbon-dioxide gas in the atmosphere is partly to blame for climate change. Climate change can have a big effect on weather conditions around the world. Scientists are looking for the best and least costly methods for capturing the gas. More
U.S. officials say birth rates for unmarried women over age 40 have been rising in recent years. In fact, the rate in 2012 was almost 30 percent higher than just five years earlier. There are single mothers by choice. They are generally older, successful, well-educated, and financially secure. More
Branden Jacobs-Jenkins' latest play 'An Octoroon,' is showing at a theater in New York City. It is based on a 19th Century work by Dion Boucicault. It tells about a white man who falls in love with a woman who is part black. At the time, mixed race marriage was banned in southern US states. More


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5 Heavily Shorted REITs That Could Pop
Regency Centers
Regency Centers (REG - Get Report) is a trust that owns and manages 215 neighborhood shopping centers spread throughout 28 states and co-owns another 181 shopping centers with partners. In total, Regency lays claim to 45 million square feet of leasable space.
At present, Regency's short interest ratio weighs in at 10.3; that means that it would take short sellers more than two weeks to cover their positions at current volume levels.
Because Regency anchors 80% of its shopping centers with grocery stores, there's an organic draw for consumers to visit stores -- and the trust can market its properties better than management firms that don't draw the same crowds. Demographics are also important for Regency: because the firm locates its properties in relatively affluent middle class locations, the firm has been benefitting from positive spending trends now that much of consumers' anxiety about the economy has settled.
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A friend of mine recently made the comment that he was amazed that so many of his friends were 'ardent philosophers' given the amount of life affirming memes and quotations that they were posting these days. A little cynical perhaps, but there's no doubt that many of us have taken to using other people's words to try to find the appropriate ways to express our thoughts. Quotes Cover takes that concept one step further by providing the whole package of quotes, graphics and typography so you to create beautiful, wordy art to illustrate your social network page. It seems ... Read more
5 Surahs is an Islamic Learning Application with 5 most read Surahs of the Holy Quran i.e. Surah Yaseen, Surah Ar-Rahman, Surah Al-Mulk, Surah Al-Waqiyah and Surah Al-Kahf. This... Read more
Stop struggling with Word & Excel or complex desktop accounting software. FastBill provides a design-award winning interface that helps freelancers and small businesses get... Read more
Daily Quotes integrates the most beautiful and powerful quotes and sayings from different sites, and provides users with the inspiration needed to face life in a different and... Read more
Quotlr follow the philosophy that some words deserve to be saved in time. We have huge collection of picture quotes, sayings and proverbs from famous and not so famous people,... Read more
For tradespeople and service businesses, finishing a days work only to spend hours sorting paperwork and admin is hard work. We believe that's time that can be spent on better... Read more
"Excellence is to do a common thing in an uncommon way." >> This quote inspire us to design a common app for you in an uncommon way. The Quote provides motivational and... Read more
Try Quilder, the free estimate software designed for tradesmen. Whether you are a joiner, plumber, roofer, electrician or any other professional in the construction industry,... Read more
Motivational Quotes App is one of the largest quote app. This App educates and entertains mobile users of all ages with the best collection of quotes from early age prominent... Read more
Funny Quote of the day is a simple application that shows a new funny quote everyday. The quotes are selected from a rich database of high quality, funny quotes. You can also... Read more


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NsGene Inc.'s innovative brain-repair therapy couldn't have come at a better time, as one of the neurodegenerative diseases it would treat – Parkinson's disease – has gotten a lot of press lately.
By Michael J. DeCicco
Contributing Writer | 9/15/14 |
An investor in two large Bay State health care companies involved in separate mergers said he doesn't expect the U.S. Treasury's recently announced measures aimed at cracking down on corporate tax inversions to derail those plans, the Boston Business Journal reported.
By PBN Staff
Nearly halfway through fiscal year 2014, National Institutes of Health grants to Rhode Island institutions are well short of the pace set in the previous year, according to figures on the NIH's website.
By Barbara Lipsche |
Taking the next steps in centralizing and building on its research capabilities, Lifespan announced Monday the creation of the Clinical Research Center, to be based at the health care conglomerate's Coro Building in Providence's Knowledge District, as well as at The Miriam Hospital in the city's East Side.
By PBN Staff
A Cherrystone Angel Group portfolio company, Windgap Medical Inc., was awarded nearly $1 million through a Massachusetts Life Sciences Center accelerator loan program.
By Eli Sherman |
The recent change in leadership at IlluminOss Medical, a commercial stage medical device company focused on minimally invasive orthopedic fracture repair, reflects its changing direction, according to those familiar with the company.
By Lori Stabile |
IlluminOss Medical has received conditional approval from the federal Food and Drug Administration to conduct a clinical trial for treatments of impending and pathologic fractures in the humerus due to metastatic carcinoma.
By PBN Staff
MassChallenge, a startup accelerator program, awarded $1.75 million at its annual startup awards ceremony Wednesday, the Boston Business Journal reported.
By PBN Staff
Venture capital firm SV Life Sciences has acquired a majority interest in Ximedica from co-founders Stephen Lane and Aidan Petrie.
By PBN Staff
The Spectranetics Corp. will acquire Covidien PLC's Stellarex drug-coated angioplasty balloon platform for $30 million.
By PBN Staff


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Bohr model Reference Libraries
Page 1 of about 1 Articles
2013-03-16 00:00:00
Niels Henrik David Bohr (October 7, 1885 - November 18, 1962) was a Danish physicist. He made essential contributions to understanding atom structure and quantum mechanics. Born in Copenhagen, Denmark to Christian Bohr and Ellen Adler, Bohr got his doctorate at Copenhagen University in 1911. He then studied under Ernest Rutherford in Manchester, England. Based on Rutherford's theories,...
Word of the Day
- A pivoted catch designed to fall into a notch on a ratchet wheel so as to allow movement in only one direction (e.g. on a windlass or in a clock mechanism), or alternatively to move the wheel in one direction.
The word 'pawl' probably comes from a Latin word meaning 'stake'.


text:
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IBM Announces New SOA Services
IBM Announces New SOA Services
Darryl K. Taft
Posted 2005-04-05
Four new sets of services provide "soup-to-nuts" consulting offerings, including design and business management.
IBMs Global Services division Tuesday announced a set of new asset-based services aimed at helping customers move to service-oriented architectures. Michael Liebow, vice president of Web services and SOA at IGS (IBM Global Services), said the new asset-based services consist of IBM software and other intellectual property, as well as best practices, and they focus on the planning, design, implementation and management of SOAs. The four new sets of services include the IBM Business Enablement Services for Service-Oriented Architecture, which helps explain to customers how SOA can help them.
Click here
to read about SAPs SOA implementation program.
The second set of services is the IBM Design Services for Service-Oriented Architecture, which helps customers map out a design for their SOA. The third set of services is the IBM Implementation Services for Service-Oriented Architecture, which helps customers build out their SOA, and the last set is the IBM Management Services for Service-Oriented Architecture, which provides monitoring and management for the SOA.
IBM Global Services also announced its new AVO (Application Value Optimization) Services, which is designed to help integrate the other four services into a customer environment.
To read more about IBMs SOA services,
click here.
"The key part of this announcement is IBMs Application Value Optimization service," said Jason Bloomberg, an analyst with ZapThink LLC, in Waltham, Mass. "This service is a part of their overall SOA consulting offering, alongside business enablement, design and implementation services. The AVO offering is the most business-oriented of these offerings, focusing on business alignment, transformation and management. Basically, IBM is rounding out their SOA consulting offering by providing soup-to-nuts technology and business services," Bloomberg said.
Check out eWEEK.coms for the latest news, reviews and analysis in Web services.
Darryl K. Taft covers the development tools and developer-related issues beat from his office in Baltimore. He has more than 10 years of experience in the business and is always looking for the next scoop. Taft is a member of the Association for Computing Machinery (ACM) and was named 'one of the most active middleware reporters in the world' by The Middleware Co. He also has his own card in the 'Who's Who in Enterprise Java' deck.
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