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CFDA 2012 Award Nominees and Honorees Complete List
The 2012 CFDA Award Nominees & Honorees
>> With a list of nominees that includes The Row's Ashley and Mary-Kate Olsen and Proenza Schouler's Jack McCollough and Lazaro Hernandez — not to mention a list of honorees that includes Rei Kawakubo and Johnny Depp — this year's CFDA Awards promise to be extra-exciting. At the announcement event in March — held at Diane von Furstenberg's studio and attended by Phillip Lim, Joe Zee, and Rachel Roy — the anticipation was nearly palpable.
"Winning a CFDA Fashion Award is the highest and one of the most coveted honors one can receive in our industry," CEO Steven Kolb said as he announced the nominees and honorees. For a complete list of those who just may receive that great honor on June 4 — as well as a list of those who definitely will, via the Council's prestigious achievement awards — see below. Then, get excited for next week's big show — which will be br>broadcast online for the first time ever this year — with an inside peek at the announcement event.
Womenswear Designer of the Year Nominees
Marc Jacobs
Ashley & Mary-Kate Olsen for The Row
Jack McCollough & Lazaro Hernandez for Proenza Schouler
Menswear Designer of the Year Nominees
Patrik Ervell
Billy Reid
Simon Spurr
Accessory Designer of the Year Nominees
Alexander Wang
Reed Krakoff
Jack McCollough & Lazaro Hernandez for Proenza Schouler
Swarovski Award For Emerging Talent in Womenswear Nominees
Joseph Altuzarra
Chris Peters & Shane Gabier for Creatures of the Wind
Max Osterweis & Erin Beatty for Suno
Swarovski Award For Emerging Talent in Menswear Nominees
Antonio Azzuolo
Todd Snyder
Phillip Lim
Swarovski Award For Emerging Talent in Accessory Design
Tabitha Simmons
Pamela Love
Irene Neuwirth
Geoffrey Beene Lifetime Achievement Award Winner
Tommy Hilfiger
International Award Winner
Rei Kawakubo
Eleanor Lambert Founders Award Winner
Andrew Rosen
Eugenia Sheppard Media Award Winners
Scott Schuman & Garance Doré
Fashion Icon Award Winner
Johnny Depp
- You're going to love these brand-new Kanye outfits — HuffPost Style
- Lupita Nyong'o's 15 greatest style moments will blow you away — Lucky
- Emily Current and Meritt Elliott created a denim destination — Who What Wear
- Wait — SkyMall may not be gone forever — The Cut
- The surprising new alternative to leather — InStyle
- Is Björk going to top our list of style icons this year? — Racked
- You need this Louis Vuitton look in your closet stat — SheFinds
- Will people still choose Gucci with Alessandro Michele's takeover? — Style.com
- How to pack light for the chicest city in the world — Man Repeller


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Costly crossover to national green schemes
PUBLISHED: 29 Jun 2012 00:03:37 | UPDATED: 29 Jun 2012 02:46:15PUBLISHED: 29 Jun 2012 PRINT EDITION: 29 Jun 2012The systematic winding up of various state-based green schemes on Sunday, in order to clear the way for a price on carbon, is costing businesses time and money as they transition across to the national counterpart programs.
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dogs - Page 5
Riverdale Apt Complex Requires Pet DNA Test – Is it Fair? [POLL]
Working for the Weekend — 15 Animals in Ties for Labor Day
Did Your Dog Make The Most Talkative List?
Dog Just Wants Someone to Play Fetch with Him [VIDEO]
Worst Friend Ever Gets Rid of Soldier's Dog Oakley While He Was Deployed
Lt. Brandon Harker returned from Afghanistan to find out that a "good friend" gave away his purebred yellow Labrador retriever named Oakley. He confronted the man who claimed not to know who he gave the dog to
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Dog Quiz
According to Amy Wright's article, which cable provider will be carrying Dogs TV? Check the article and answer the quiz!


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The amenities and view are there but one would expect more for one's money in a "5 star" accommodation than was offered. There was a pool, yes, but it was not clean---full of leaves and slimy at the bottom. There was a hot tub, but the water looked suspect. The room was not serviced on a daily basis---we stayed in... More
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Salix Pharmaceuticals Outlines Data Presentations At PAINWeek
RELISTOR Subcutaneous Injection was approved in the United States in 2008 for the treatment of opioid-induced constipation in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient. The use of RELISTOR beyond four months has not been studied. The drug is also approved for use in 58 countries worldwide, including the European Union, Canada and Australia. In the 27 member states of the E.U., as well as Iceland, Norway and Liechtenstein, RELISTOR is approved for the treatment of opioid–induced constipation in advanced illness patients who are receiving palliative care when response to usual laxative therapy has not been sufficient. In Canada, the drug is approved for the treatment of opioid–induced constipation in patients with advanced illness, receiving palliative care. When response to laxatives has been insufficient, RELISTOR should be used as an adjunct therapy to induce a prompt bowel movement. Applications in additional countries are pending. RELISTOR is under exclusive license to Salix Pharmaceuticals worldwide except Japan, and to Ono Pharmaceutical in Japan only, from Progenics Pharmaceuticals. Salix is developing both subcutaneous injection and oral formulations of methylnaltrexone bromide for the potential treatment of opioid-induced constipation in adult patients with chronic, non-cancer pain.
For more information about RELISTOR, please visit www.RELISTOR.com.
Important Safety Information for RELISTOR
RELISTOR is indicated for the treatment of opioid–induced constipation in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient. Use of RELISTOR beyond four months has not been studied.
RELISTOR is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. If severe or persistent diarrhea occurs during treatment, advise patients to discontinue therapy with RELISTOR and consult their physician. Use of RELISTOR has not been studied in patients with peritoneal catheters. Safety and efficacy of RELISTOR have not been established in pediatric patients.Check Out Our Best Services for Investors
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Hey, as the title says, can anyone tell me how to factory reset a completely dead nexus 4 (red light when charging)? I'm about to sell it and would prefer it to be wiped in case it get fixed by a new user. Any help would be appreciated.
Why don't you just fix the nexus 4, it's not too hard to fix red light of death and you could sell it for more. Sent from my Nexus 7 using XDA Free mobile app


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Floor Plan Download
Download Floor Plan to pin point the location of your prefered employer
7 - 9 March 2014 | 10am - 7pm | Mid Valley Exhibition Centre, Kuala Lumpur
The MCTF'14 (Malaysia Career & Training Fair 2014) is back in March featuring over 150 companies from various industries – companies looking for talented, enthusiastic, and bright people like you. Meet them face-to-face at the fair, speak to them, and impress them. Don't miss this chance to showcase your resume and attract both local and international top companies from this career fair.
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FNC AppyB
Senior Member
Ah yes I remember this case very well that I clicked punish on and rightly so, never have I seen a case more deserving
got my second now
Mourn the loss of the player for he hath not learned what he hath done. Yea, though I walk thru the valley in the shadow of troll I shall fear no tribunal judgement. For summoners code is with me. As well as Wheaton's law.
Ada Wong
HAHA i remember playing with this TROLL good ridance :O


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EVANSTON, Ill. — Drew McDonough walks quickly past the 50-pound bags of brown sugar and the huge tubs of chocolate frosting. He takes a second to clock in at a computer, dresses in his bakery clothes (hairnet, work shirt, apron), and then speed-walks toward the stainless steel table where, five days a week, he packages cups of sticky toffee pudding.
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There's nothing like a classic favorite—but if you're in the mood for a change, check out our weekly specials! With over 130 flavor variations, our collection of distinctive and seasonal drinks is sure to liven up your day.
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Glad to be 1/4000
This is a discussion on CC has over 4,000 members!! within the Old Forum News, Feedback, Problems & Comments forums, part of the DefensiveCarry.com Forum Office category; Glad to be 1/4000...
Glad to be 1/4000
"Better to have it and not need it, than to need it and not have it."
To all the people that are dedicated to making this forum work. To all of us here with the tons and tons of knowledge that we all share. I say thanks.
Pretty soon we will have a lobby in D.C.(?). ................Well,maybe not.---------
Last edited by RSSZ; June 18th, 2006 at 09:58 PM.
Strength in numbers!
The Dragon has time and experience. Maturity has given him knowledge, strength, skill, wisdom and inner peace.
Glock 26 Certified Glock Armorer
Mossberg 590 12 ga.
I too say thanks to the creators, mods, and fine members who make this place what it is!


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Lift-off achieved
Jeff Smith 6 p.m., Feb. 27
Birder Jeanne Raimond leads an avian adventure. Observe nesting migratories and local birds with new offspring. Hear their songs. Binoculars and bird book recommended. Meet at Campground Day Use Entry Station.
Two Father Junípero Serra Trail, San Diego, 92119
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This is a bueatiful home with a open floor plan. 2 full bathroom , three bedrooms with ample living space in the basement. This ......
Subdivision: Spring Crk Estates Sec 06
Greece, NY 14612
Foreclosure Real Estate
3 Bedroom, 1 Bath1,092 SqFt 0.28 SqFt Lot0.2800 Acres
Single Family Home
3 bedroom ranch with attached 2 car garage, and private fenced backyard. Newer windows, tankless water heater, newer boiler (200......
Subdivision: Berkshire Mdws Add
Greece, NY 14626
3 Bedroom, 2.5 Bath1,490 SqFt 0.43 SqFt Lot0.4300 Acres
Short sale. Subject to bank approval must purchase in "as is condition" call for easy showing......
3 Bedroom, 1.5 Bath1,767 SqFt 0.30 SqFt Lot0.3000 Acres
The possibilities are many and the price is crazy for this 3405 sq ft of living space with an additional huge finished lower lev......
Neighborhood: Maplewood
Subdivision: Defendorf Estate
Greece, NY 14616
7 Bedroom, 2.5 Bath3,405 SqFt 0.21 SqFt Lot0.2100 Acres
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Reduced by $10,000 (11.12%) on 11/11/14
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Subdivision: Stonecroft
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3 Bedroom, 2.5 Bath1,512 SqFt 0.17 SqFt Lot0.1700 Acres
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and Boise lost to 4-9 Washington in 07. Not to mention we got bitchslapped at home by that same midmajor. But, Bama followed up with 1 loss to the national champs in 08 and didn't give 2 rips about the Sugar Bowl, much like we didn't give 2 rips about the Rose Bowl in 06. You really think a team can get up for a game when they were 1 game away from the National Title game??
It simply doesn't happen, hell Auburn who didn't get a shot at it on 04 looked like crap against Va Tech in the Sugar Bowl but found a way to win it.


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Industrial relations
TWU sticks to pay claims at Qantas
PUBLISHED: 27 Mar 2012 00:02:20 | UPDATED: 27 Mar 2012 02:55:17PUBLISHED: 27 Mar 2012 PRINT EDITION: 27 Mar 2012Qantas Airways faces a push for pay rises of 5 per cent a year and strengthened job protection in the airline's first forced arbitration of a new workplace agreement for almost 30 years.
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Publications (155)641.31 Total impact
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ABSTRACT: Store-operated Ca2+ entry, essential for the adaptive immunity, is initiated by the endoplasmic reticulum (ER) Ca2+ sensor STIM1. Ca2+ entry occurs through the plasma membrane resident Ca2+ channel Orai1 that directly interacts with the C-terminal STIM1 domain, named SOAR/CAD. Depletion of the ER Ca2+ store controls this STIM1/Orai1 interaction via transition to an extended STIM1 C-terminal conformation, exposure of the SOAR/CAD domain and STIM1/Orai1 co-clustering. Here we developed a novel approach termed FRET-derived Interaction in a Restricted Environment (FIRE) in an attempt to dissect the interplay of coiled-coil (CC) interactions in controlling STIM1 quiescent as well as active conformation and cluster formation. We present evidence of a sequential activation mechanism in the STIM1 cytosolic domains where the interaction between CC1 and CC3 segment regulates both SOAR/CAD exposure and CC3-mediated higher-order oligomerization as well as cluster formation. These dual levels of STIM1 auto-inhibition provide efficient control over the coupling to and activation of Orai1 channels.Journal of Biological Chemistry 10/2014; · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective calcium channel that has been considered as a part of store-operated calcium entry (SOCE). Despite its first discovery in the early 2000s, the role of this channel in prostate cancer (PCa) remained, until now, obscure. Here we show that TRPV6 mediates calcium entry, which is highly increased in PCa due to the remodeling mechanism involving the translocation of the TRPV6 channel to the plasma membrane via the Orai1/TRPC1-mediated Ca(2+)/Annexin I/S100A11 pathway, partially contributing to SOCE. The TRPV6 calcium channel is expressed de novo by the PCa cell to increase its survival by enhancing proliferation and conferring apoptosis resistance. Xenografts in nude mice and bone metastasis models confirmed the remarkable aggressiveness of TRPV6-overexpressing tumors. Immunohistochemical analysis of these demonstrated the increased expression of clinical markers such as Ki-67, prostate specific antigen, synaptophysin, CD31, and CD56, which are strongly associated with a poor prognosis. Thus, the TRPV6 channel acquires its oncogenic potential in PCa due to the remodeling mechanism via the Orai1-mediated Ca(2+)/Annexin I/S100A11 pathway.Proceedings of the National Academy of Sciences 08/2014; · 9.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Orai proteins contribute to Ca(2+) entry into cells through both store-dependent, Ca(2+) release-activated Ca(2+) (CRAC) channels (Orai1) and store-independent, arachidonic acid (AA)-regulated Ca(2+) (ARC) and leukotriene C4 (LTC4)-regulated Ca(2+) (LRC) channels (Orai1/3 heteromultimers). Although activated by fundamentally different mechanisms, CRAC channels, like ARC and LRC channels, require stromal interacting molecule 1 (STIM1). The role of endoplasmic reticulum-resident STIM1 (ER-STIM1) in CRAC channel activation is widely accepted. Although ER-STIM1 is necessary and sufficient for LRC channel activation in vascular smooth muscle cells (VSMCs), the minor pool of STIM1 located at the plasma membrane (PM-STIM1) is necessary for ARC channel activation in HEK293 cells. To determine whether ARC and LRC conductances are mediated by the same or different populations of STIM1, Orai1, and Orai3 proteins, we used whole-cell and perforated patch-clamp recording to compare AA- and LTC4-activated currents in VSMCs and HEK293 cells. We found that both cell types show indistinguishable nonadditive LTC4- and AA-activated currents that require both Orai1 and Orai3, suggesting that both conductances are mediated by the same channel. Experiments using a nonmetabolizable form of AA or an inhibitor of 5-lipooxygenase suggested that ARC and LRC currents in both cell types could be activated by either LTC4 or AA, with LTC4 being more potent. Although PM-STIM1 was required for current activation by LTC4 and AA under whole-cell patch-clamp recordings in both cell types, ER-STIM1 was sufficient with perforated patch recordings. These results demonstrate that ARC and LRC currents are mediated by the same cellular populations of STIM1, Orai1, and Orai3, and suggest a complex role for both ER-STIM1 and PM-STIM1 in regulating these store-independent Orai1/3 channels.The Journal of General Physiology 03/2014; 143(3):345-59. · 4.57 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). The cytosolic region of STIM1 contains a long putative coiled-coil (CC)1 segment and shorter CC2 and CC3 domains. Here we present solution nuclear magnetic resonance structures of a trypsin-resistant CC1-CC2 fragment in the apo and Orai1-bound states. Each CC1-CC2 subunit forms a U-shaped structure that homodimerizes through antiparallel interactions between equivalent α-helices. The CC2:CC2' helix pair clamps two identical acidic Orai1 C-terminal helices at opposite ends of a hydrophobic/basic STIM-Orai association pocket. STIM1 mutants disrupting CC1:CC1' interactions attenuate, while variants promoting CC1 stability spontaneously activate Orai1 currents. CC2 mutations cause remarkable variability in Orai1 activation because of a dual function in binding Orai1 and autoinhibiting STIM1 oligomerization via interactions with CC3. We conclude that SOCE is activated through dynamic interplay between STIM1 and Orai1 helices.Nature Communications 12/2013; 4:2963. · 10.74 Impact Factor - Channels (Austin, Tex.) 11/2013; 7(5). · 2.32 Impact Factor
Article: The STIM1/Orai signaling machinery.
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ABSTRACT: Ca (2+) influx via store-operated Ca (2+) release activated Ca (2+) (CRAC) channels represents a main signaling pathway for T-cell activation as well as mast-cell degranulation. The ER-located Ca (2+)-sensor, STIM1 and the Ca (2+)-selective ion pore, Orai1 in the membrane are sufficient to fully reconstitute CRAC currents. Their identification, but even more the recent structural resolution of both proteins by X-ray crystallography has substantially advanced the understanding of the activation mechanism of CRAC channels. In this review, we provide a detailed description of the STIM1/Orai1 signaling pathway thereby focusing on the critical domains mediating both, intra- as well as intermolecular interactions and on the ion permeation pathway. Based on the results of functional studies as well as the recently published crystal structures, we portray a mechanistic view of the steps in the CRAC channel signaling cascade ranging from STIM1 oligomerization over STIM1-Orai1 coupling to the ultimate Orai1 channel activation and permeation.Channels (Austin, Tex.) 10/2013; 7(5). · 2.32 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Sirolimus (rapamycin) is used in drug-eluting stent strategies and proved clearly superior in this application as compared to other immunomodulators such as pimecrolimus. The molecular basis of this action of sirolimus in the vascular system is still incompletely understood. Measurements of cell proliferation in human coronary smooth muscle cells (hCASM) demonstrated a higher antiproliferative activity of sirolimus as compared to pimecrolimus. Although sirolimus lacks inhibitory effects on calcineurin, NFAT activation in hCASM was suppressed to a similar extent by both drugs at 10 µM. Sirolimus, but not pimecrolimus, inhibited agonist-induced and store-operated Ca(2+) entry as well as CREB phosphorylation in human arterial smooth muscle suggesting the existence of an as yet unrecognized inhibitory effect of sirolimus on Ca(2+) signaling and Ca(2+)-dependent gene transcription. Electrophysiological experiments revealed that only sirolimus but not pimecrolimus significantly blocked the classical STIM/Orai-mediated, store-operated Ca(2+) current reconstituted in HEK293 cells. A link between Orai function and proliferation was confirmed by dominant negative knockout of Orai in hCASM. Analysis of the effects of sirolimus on cell proliferation and CREB activation in an in vitro model of arterial intervention using human aorta corroborated the ability of sirolimus to suppress stent implantation-induced CREB activation in human arteries. We suggest inhibition of store-operated Ca(2+) entry based on Orai channels and the resulting suppression of Ca(2+) transcription coupling as a key mechanism underlying the antiproliferative activity of sirolimus in human arteries. This mechanism of action is specific for sirolimus and not a general feature of drugs interacting with FKBPs.AJP Heart and Circulatory Physiology 09/2013; · 4.01 Impact Factor -
Article: Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.
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ABSTRACT: We recently showed, in primary vascular smooth muscle cells (VSMCs), that the platelet-derived growth factor activates canonical store-operated Ca(2+) entry and Ca(2+) release-activated Ca(2+) currents encoded by Orai1 and STIM1 genes. However, thrombin activates store-independent Ca(2+) selective channels contributed by both Orai3 and Orai1. These store-independent Orai3/Orai1 channels are gated by cytosolic leukotriene C4 (LTC4) and require STIM1 downstream LTC4 action. However, the source of LTC4 and the signaling mechanisms of STIM1 in the activation of this LTC4-regulated Ca(2+) (LRC) channel are unknown. Here, we show that upon thrombin stimulation, LTC4 is produced through the sequential activities of phospholipase C, diacylglycerol lipase, 5-lipo-oxygenease, and leukotriene C4 synthase. We show that the endoplasmic reticulum-resident STIM1 is necessary and sufficient for LRC channel activation by thrombin. STIM1 does not form sustained puncta and does not colocalize with Orai1 either under basal conditions or in response to thrombin. However, STIM1 is precoupled to Orai3 and Orai3/Orai1 channels under basal conditions as shown using Forster resonance energy transfer (FRET) imaging. The second coiled-coil domain of STIM1 is required for coupling to either Orai3 or Orai3/Orai1 channels and for LRC channel activation. We conclude that STIM1 employs distinct mechanisms in the activation of store-dependent and store-independent Ca(2+) entry pathwaysMolecular and Cellular Biology 09/2013; 33(18):3715-3723. · 5.04 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: STIM1 and Orai1 represent the two molecular key components of the Ca2+ release-activated Ca2+-channels. Their activation involves STIM1 C-terminus coupling to both Orai-N- and -C-terminus. Here we focused on the extended transmembrane Orai1 N-terminal (ETON, aa73-90) region, conserved among the Orai family forming an elongated helix of TM1 as recently shown by X-ray crystallography. In order to identify hot spot-residues in the ETON binding interface for STIM1-interaction, numerous Orai1-constructs with N-terminal truncations or point mutations within the ETON region were generated. N-terminal truncations of the first four residues of the ETON region or beyond completely abolished STIM1-dependent Orai1-function. Loss of Orai1-function resulted from neither an impairment of plasma membrane targeting nor pore damage, but from a disruption of STIM1-interaction. Complementary we monitored STIM1-Orai-interaction via Orai1-V102A by determining restored Ca2+-selectivity as a consequence of STIM1-coupling. Orai1 N-terminal truncations that led to a loss of function consistently failed to restore Ca2+-selectivity of Orai1-V102A in the presence of STIM1 demonstrating impairment of STIM1-binding. Hence, the major portion of the ETON region (aa76-90) is essential for STIM1-binding and Orai1-activation. Mutagenesis within the ETON region revealed several hydrophobic and basic hot spot-residues that appear to control STIM1-coupling to Orai1 in a concerted manner. Moreover, we identified two basic residues, which protrude into the elongated pore to redound to Orai1-gating. In aggregate, we suggest that several hot spot-residues in the ETON region contribute to the binding of STIM1, which in turn is coupled to a conformational reorientation of the gate.Journal of Biological Chemistry 08/2013; · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We recently showed in primary vascular smooth muscle cells (VSMC), that the platelet-derived growth factor activates canonical store-operated Ca(2+) entry and Ca(2+) release-activated Ca(2+) currents encoded by Orai1 and STIM1. However, thrombin activates store-independent Ca(2+) selective channels contributed by both Orai3 and Orai1. These store-independent Orai3/Orai1 channels are gated by cytosolic leukotrieneC4 (LTC4) and require STIM1 downstream LTC4 action. However, the source of LTC4 and the signaling mechanisms of STIM1 in the activation of this LTC4-regulated Ca(2+) (LRC) channel are unknown. Here we show that upon thrombin stimulation, LTC4 is produced through the sequential activities of phospholipase C, diacylglycerol lipase, 5-lipo-oxygenease and leukotrieneC4 synthase. We show that the endoplasmic reticulum-resident STIM1 is necessary and sufficient for LRC channel activation by thrombin. STIM1 does not form sustained puncta and does not co-localize with Orai1 either under basal conditions or in response to thrombin. However, STIM1 is pre-coupled to Orai3 and Orai3/Orai1 channels under basal conditions as shown using FRET imaging. The second coiled-coil domain of STIM1 is required for coupling to either Orai3 or Orai3/Orai1 channels and for LRC channel activation. We conclude that STIM1 employs distinct mechanisms in the activation of store-dependent and store-independent Ca(2+) entry pathways.Molecular and Cellular Biology 07/2013; · 5.04 Impact Factor -
Article: A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.
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ABSTRACT: Utilizing a novel molecular model of TRPC3, based on the voltage-gated sodium channel from Arcobacter butzleri (NaVAB) as template, we performed structure-guided mutagenesis experiments to identify amino acid residues involved in divalent permeation and gating. Substituted cysteine accessibility screening within the predicted selectivity filter uncovered amino acids 629-631 as the narrowest part of the permeation pathway with an estimated pore diameter of <5.8Å. E630 was found to govern not only divalent permeability but also sensitivity of the channel to block by ruthenium red. Mutations in a hydrophobic cluster at the cytosolic termini of transmembrane segment 6, corresponding to the S6 bundle crossing structure in NaVAB, distorted channel gating. Removal of a large hydrophobic residue (I667A or I667E) generated channels with approximately 60% constitutive activity, suggesting I667 as part of the dynamic structure occluding the permeation path. Destabilization of the gate was associated with reduced Ca(2+) permeability, altered cysteine cross-linking in the selectivity filter and promoted channel block by ruthenium red. Collectively, we present a structural model of the TRPC3 permeation pathway and localize the channel's selectivity filter and the occluding gate. Moreover, we provide evidence for allosteric coupling between the gate and the selectivity filter in TRPC3.Cell calcium 06/2013; · 4.29 Impact Factor -
Article: Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.
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ABSTRACT: RTN1A is a reticulon protein with predominant localization in the endoplasmic reticulum (ER). It was previously shown that RTN1A is expressed in neurons of the mammalian central nervous system but functional information remains sparse. To elucidate the neuronal function of RTN1A, we chose to focus our investigation on identifying possible novel binding partners specifically interacting with the unique N-terminus of RTN1A. Using a nonbiased approach involving GST pull-downs and MS analysis, we identified the intracellular calcium release channel ryanodine receptor 2 (RyR2) as a direct binding partner of RTN1A. The RyR2 binding site was localized to a highly conserved 150-amino acid residue region. RTN1A displays high preference for RyR2 binding in vitro and in vivo and both proteins colocalize in hippocampal neurons and Purkinje cells. Moreover, we demonstrate the precise subcellular localization of RTN1A in Purkinje cells and show that RTN1A inhibits RyR channels in [3H]ryanodine binding studies on brain synaptosomes. In a functional assay, RTN1A significantly reduced RyR2-mediated Ca2+ oscillations. Thus, RTN1A and RyR2 might act as functional partners in the regulation of cytosolic Ca2+ dynamics in neurons.Biochimica et Biophysica Acta 02/2013; · 4.66 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Rationale: Through largely unknown mechanisms, Ca(2+) signaling plays important roles in vascular smooth muscle cell (VSMC) remodeling. Orai1-encoded store-operated Ca(2+) entry (SOCE) has recently emerged as an important player in VSMC remodeling. However, the role of the exclusively mammalian Orai3 protein in native VSMC Ca(2+) entry pathways, its upregulation during VSMC remodeling and its contribution to neointima formation remain unknown. Objective: The goal of this study was to determine the agonist-evoked Ca(2+) entry pathway contributed by Orai3; Orai3 potential upregulation and role during neointima formation after balloon-injury of rat carotid arteries. Methods and Results: Ca(2+) imaging and patch clamp recordings showed that while the platelet-derived growth factor (PDGF) activates the canonical Ca(2+) release-activated Ca(2+) (CRAC) channels via store depletion in VSMC, the pathophysiological agonist thrombin activates a distinct Ca(2+)-selective channel contributed by Orai1, Orai3 and STIM1 in the same cells. Unexpectedly, Ca(2+) store depletion is not required for activation of Orai1/3 channel by thrombin. Rather, the signal for Orai1/3 channel activation is cytosolic leukotrieneC4 produced downstream thrombin receptor stimulation through the catalytic activity of leukotrieneC4 synthase. Importantly, Orai3 is upregulated in an animal model of VSMC neointimal remodeling and in vivo Orai3 knockdown inhibits neointima formation. Conclusions: These results demonstrate that distinct native Ca(2+)-selective Orai channels are activated by different agonists/pathways and uncover a mechanism whereby leukotrieneC4 acts through hitherto unknown intracrine mode to elicit store-independent Ca(2+) signaling that promotes vascular occlusive disease. Orai3 and Orai3-containing channels provide novel targets for control of VSMC remodeling during vascular injury or disease.Circulation Research 01/2013; · 11.09 Impact Factor - Biophysical Journal 01/2013; 104(2):455-. · 3.83 Impact Factor
- Biophysical Journal 01/2013; 104(2):615-. · 3.83 Impact Factor
- Biophysical Journal 01/2013; 104(2):457-. · 3.83 Impact Factor
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ABSTRACT: As the molecular composition of calcium-release activated calcium (CRAC) channels has been unknown for two decades, elucidation of selective inhibitors has been considerably hampered. By the identification of the two key components of CRAC channels, STIM1 and Orai1 have emerged as promising targets for CRAC blockers. The aim of this study was to thoroughly characterize the effects of two selective CRAC channel blockers on currents derived from STIM1/Orai heterologoulsy expressed in HEK293 cells. The novel compounds GSK-7975A and GSK-5503A were tested for effects on STIM1 mediated Orai1 or Orai3 currents by whole-cell patch-clamp recordings and for the effects on STIM1 oligomerisation or STIM1/Orai coupling by FRET microscopy. To investigate their site of action, inhibitory effects of these molecules were explored using Orai pore mutants. The GSK blockers inhibited Orai1 and Orai3 currents with an IC(50) of approximately 4μM and exhibited a substantially slower rate of onset than the typical pore blocker La(3+), together with almost no current recovery upon wash-out over 4min. For the less Ca(2+)-selective Orai1 E106D pore mutant, I(CRAC) inhibition was significantly reduced. FRET experiments indicated that neither STIM1-STIM1 oligomerization nor STIM1-Orai1 coupling was affected by these compounds. These CRAC channel blockers are acting downstream of STIM1 oligomerization and STIM1/Orai1 interaction, potentially via an allosteric effect on the selectivity filter of Orai. The elucidation of these CRAC current blockers represents a significant step toward the identification of CRAC channel-selective drug compounds.Cell calcium 12/2012; · 4.29 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: TRP proteins mostly assemble to homomeric channels but can also heteromerize, preferentially within their subfamilies. The TRPC1 protein is the most versatile member and forms various TRPC channel combinations but also unique channels with the distantly related TRPP2 and TRPV4. We show here a novel cross-family interaction between TRPC1 and TRPV6, a Ca(2+) selective member of the vanilloid TRP subfamily. TRPV6 exhibited substantial co-localization and in vivo interaction with TRPC1 in HEK293 cells, however, no interaction was observed with TRPC3, TRPC4, or TRPC5. Ca(2+) and Na(+) currents of TRPV6-overexpressing HEK293 cells are significantly reduced by co-expression of TRPC1, correlating with a dramatically suppressed plasma membrane targeting of TRPV6. In line with their intracellular retention, remaining currents of TRPC1 and TRPV6 co-expression resemble in current-voltage relationship that of TRPV6. Studying the N-terminal ankyrin like repeat domain, structurally similar in the two proteins, we have found that these cytosolic segments were sufficient to mediate a direct heteromeric interaction. Moreover, the inhibitory role of TRPC1 on TRPV6 influx was also maintained by expression of only its N-terminal ankyrin-like repeat domain. Our experiments provide evidence for a functional interaction of TRPC1 with TRPV6 that negatively regulates Ca(2+) influx in HEK293 cells.Journal of Biological Chemistry 08/2012; 287(42):35612-20. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background and purpose: Pyrazole derivatives have recently been suggested as selective blockers of TRPC channels but their ability to distinguish between TRPC and Orai pore complexes is ill-defined. This study was designed to characterize a series of pyrazole derivatives in terms of TRPC/Orai selectivity and to delineate consequences of selective suppression of these pathways for mast cell activation. Experimental approach: Pyrazoles were generated by microwave-assisted synthesis and tested for effects on Ca(2+) entry by Fura-2 imaging and membrane currents by patch-clamp recording. Experiments were performed in HEK293 cells overexpressing TRPC3 and in RBL-2H3 mast cells, which express classical store-operated Ca(2+) entry mediated by Orai channels. The consequences of inhibitory effects on Ca(2+) signalling in RBL-2H3 cells were investigated at the level of both degranulation and NFAT activation Key Results: Pyr3, a previously suggested selective inhibitor of TRPC3 channels, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency. By contrast, Pyr6 exhibited a 37-fold higher potency to inhibit Orai1-mediated Ca(2+) entry as compared to TRPC3-mediated Ca(2+) entry and potently suppressed mast cell activation. The novel pyrazole Pyr10 displayed substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation. Conclusions and Implications: The pyrazole derivatives Pyr6 and Pyr10 are able to distinguish between TRPC and Orai-mediated Ca(2+) entry and may serve as useful tools for the analysis of cellular functions of the underlying Ca(2+) channels. © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.British Journal of Pharmacology 08/2012; · 5.07 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Store-operated Ca(2+) entry describes the phenomenon that connects a depletion of internal Ca(2+) stores to an activation of plasma membrane-located Ca(2+) selective ion channels. Tremendous progress towards the underlying molecular mechanism came with the discovery of the two respective limiting components, STIM and Orai. STIM1 represents the ER-located Ca(2+) sensor and transmits the signal of store depletion to the plasma membrane. Here it couples to and activates Orai, the highly Ca(2+)-selective pore-forming subunit of Ca(2+) release-activated Ca(2+) channels. In this review, we focus on the molecular steps that these two proteins undergo from store-depletion to their coupling, the activation, and regulation of Ca(2+) currents.Cellular and Molecular Life Sciences CMLS 07/2012; 69(24). · 5.86 Impact FactorThis article is viewable in ResearchGate's enriched format
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Should we throw cold water on the 'Ice Bucket Challenge'? CTCA August 15, 2014 If you've been on Facebook or Twitter recently, you've probably seen the Ice Bucket Challenge. The campaign asks people to donate $100 to ALS research or pour a bucket of ice water over their head. Anyone who performs this feat on camera then nominates several friends to take the same challenge for ALS, an incurable, neurodegenerative disease also known as Lou Gherig's disease. Read full post
PALB2 gene mutations may increase breast cancer risk Melanie Corbman, MS, LCGC August 14, 2014 The PALB2 gene made news recently when researchers found that its mutated form is associated with a surprisingly high risk of breast cancer. Women with a PALB2 mutation have a 35 percent risk of developing breast cancer by age 70. The risk for women younger than 40 was eight to nine times that of the general population. Read full post
Avoid UV rays to reduce skin cancer risk Laurence Altshuler, MD August 13, 2014 The United States surgeon general recently issued the warning that skin cancer is a "major public health problem" and that too much exposure to indoor and outdoor ultraviolet (UV) light is a major cause. Having treated numerous patients with various skin cancers, I certainly agree with that warning. Read full post
HPV test or Pap test for cervical cancer screening? CTCA August 11, 2014 If you're between ages 30 and 65, you may have had the HPV test along with a Pap test as part of routine screening. For almost 60 years, the Pap test has been the preferred way to detect early pre-cancerous changes that can lead to cervical cancer, but can the newer HPV test do a better job? Researchers have been studying the question for more than 15 years and their results support the idea that the HPV test could be the primary cervical cancer screening tool. Read full post
Cancer Fighter® gives back to those battling cancer CTCA August 08, 2014 For pancreatic cancer survivor Cissy Hass, giving back to those currently battling cancer is about sharing her blessings. As a member of the Cancer Fighters® program at our hospital near Atlanta, Hass shares her cancer journey with potential patients to provide hope and camaraderie. Read full post
Study links breast cancer to high-dose estrogen birth control pills CTCA August 08, 2014 You may have heard that taking the birth control pill increases your risk of cancer, but does it matter which pill you take? A team of researchers analyzed different pill types and found a 50 percent increase in breast cancer risk among women taking high-dose estrogen pills. The good news is that low-dose pills did not seem to increase breast cancer risk, according to the recent study in Cancer Research. Today, most women on birth control pills use the low-dose kind. Read full post
Are chronic pain and emotion connected? Raed Rahman, DO August 06, 2014 Over the past decade, researchers have given more thought to the connection between your emotions and how you experience pain. They have begun to adopt a more evolved view, moving beyond the traditional notion that negative emotions are unhealthy and must be rationally controlled. Read full post
Managing side effects with acupuncture during breast cancer treatment Gurneet Singh, ND, LAc August 04, 2014 During treatment for breast cancer, some patients receive acupuncture to manage side effects and improve quality of life. Acupuncture is an ancient medical practice which involves the gentle insertion of small needles that stimulate specific therapeutic points on the body to restore harmony and balance. Read full post
Snack on this scrumptious protein booster CTCA July 31, 2014 Video: Nutrition Therapy at CTCA – Quick BitesLooking for a snack that's healthy and easy to make? Follow this recipe for baked chick pea bites. Looking for a healthy snack to fuel your hike or bike rides this summer? Samantha Quagliano, MS, RD, a dietitian at our suburban Phoenix hospital, has a recipe for Chickpea Bites, an easy-to-make-and-bake energy and protein booster. Read full post
Natural vs. refined sugars: What's the difference? CTCA July 30, 2014 Sugar, in all forms, is a simple carbohydrate that the body converts into glucose and uses for energy. But the effect on the body and your overall health depends on the type of sugar you're eating, either natural or refined. We wanted to explore the difference between these sugar types as a follow-up to our post about whether sugar drives the growth of cancer, which has received several comments. Read full post


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I am looking for any information on an Alfred and Anna McHone of Kansas. Alfred was born about 1839 and and was born abt 1835. Some of their chidren were Lida, John and Minerva Jane. Minerva Jane went on to marry an William Allen Fenwick.
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You must earn 10,000 points to post other members' whiteboard
The Chevron Houston Marathon is January 18. CSQUARED and his girlfriend are scheduled to run. We will be meeting them after the race for our annual Gasbuddy get-together. Hopefully, some of you can make plans to join us at 3:00. Saltgrass Steak House – Kemah Boardwalk 215 Kipp Avenue (281) 538-5441 We can ride down together if you want, just let me know.
Hope all is well, have not seen you around for a while, but I guess I have been hit and miss as well. Merry Christmas.
There's a decent chance that you can contact the site Moderators and ask to have your consecutive days reinstated because you were at the retreat.......Just an idea.
Hope you made it over to Great Wolf Lodge
Yeah I did the same thing, I was at 975 and lost all. You can contact the monitors and they will reinstate your points. They give you two do-overs for times like these.
I am with you buddy. the system is all messed up. Middle America ( that is paying for everything) is getting smaller and Smaller and they are paying more and more to prop up the system. I say Flat Tax (which will never happen) is the way to go. Make the Mega companies pay their share, take a way the free stuff from the freeloaders ( or at least get a handle on the out-of-control fraud). Any way I feel your frustration.
Thanks. You have nice toys
Thanks for the congrats on my new car.
I miss R-12! Bud's? ~drill'.
Welcome to the Elite club...ALL TIME POINTS LEADER BOARD... GREAT JOB!!!... CONGRATS, I am trying to get there... MY NEWEST GB...AL


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COLUMN - Supreme Court ruling on Kasab brings partial closure
The Mumbai attacks of Nov 26, 2008 (often referred to as India's 26/11) reached partial closure on Wednesday with the decision by the Supreme Court to uphold the conviction and death sentence awarded to the lone surviving gunman, Mohammad Ajmal Kasab, in May 2010 for his role in the carnage that took 166 lives. Apart from Indian citizens who bore the brunt of the attack, there were as many as 25 other nations whose citizens were either killed or injured. Jews were particularly targeted.
The enormity of 26/11 and the manner in which Kasab and his team killed scores of civilians was captured live on TV footage and the telephone communication with the 'handlers' in Pakistan gave the entire event a macabre quality where the real and reel telescoped into each other. At that time in late 2008, emotions ran high in India and angry, collective revenge had to be kept at bay so that justice could be rendered to the victims and their families who suffered grievous loss.
India sets considerable import to what is called the 'due process of the law' and despite the enormous trial court backlog, the Kasab case moved fairly swiftly by Indian standards and the case reached the Supreme Court. To that extent it may be inferred, that at a purely individual level, some degree of justice has been rendered with the decision of the Supreme Court, which has opined that the accused was accorded a fair trial and the gravity of the crime -- "participated in waging war against the country" -- warranted the death penalty.
However, Kasab is unlikely to go to the gallows in a hurry for in all likelihood, the August 29 decision will be sent for appeal and a review and if rejected, the case could finally be referred to the President of India for mercy. What is germane is that one of the surviving perpetrators of a major terror attack could be prosecuted through the law of the land and that 'due process' was respected. The degree of solace that this kind of justice will provide to the families of the victims is moot and some foreign nationals may still seek different forms of redress and compensation through their own legal provisions.
The larger and more complex issue of 26/11 is the linkage with the Pakistani security apex, for as an individual, Kasab was a mere foot soldier -- albeit lethal in killing unarmed innocents. The Supreme Court judgement noted inter alia: "The most clinching evidence regarding conspiracy comes from the recordings of intercepted telephone calls between the terrorists and their co-conspirators and collaborators sitting in a foreign land that, in light of the overall facts and circumstances of the case, can only be Pakistan". The linkage between the perpetrators of 26/11 with the Lashkar-e-Taiba and the support that this group has traditionally received from the Rawalpindi GHQ is part of a well-known narrative about the patterns of cross-border terror in the region. This has now been reiterated by the highest court in India.
It may be recalled that in the immediate aftermath of 26/11, the first reaction of the Pakistani security establishment was to deny Kasab's nationality as a Pakistani and it took an intrepid Pakistani journalist to expose the truth. In the intervening years, there has been more innovative opacity than sincere intent on the part of the Pakistani security establishment to prosecute the high-level handlers of the Kasab team -- and this is predictable.
The 26/11 carnage and the reluctance of the Pakistan government to enable speedy prosecution on their side will come up for discussion in the Tehran meeting between Indian PM Manmohan Singh and the Pakistani President Asif Ali Zardari, where they are expected to meet on the sidelines of the NAM Summit.
But the reality is that the Pakistani security establishment had deliberately invested in terror groups as part of the 'strategic depth' doctrine more than 20 years ago and this policy has neither been reviewed nor altered. Lest this assertion be seen as partisan, it may be recalled that soon after the terror attack (Aug 16) on the Kamra airbase near Islamabad, a noted Pakistani security analyst made an insightful and courageous observation.
Ayesha Siddiqa averred that despite General Kayani asserting that the war on terror is Pakistan's own war -- there was no policy shift towards groups espousing the ideology of terror. She added: "Groups such as the Lashkar-e-Taiba (LeT), Jaish-e-Mohammad, Sipah-e-Sahaba and Lashkar-e-Jhangvi, which have safe havens in the country (Pakistan), continue to thrive."
In a non-linear manner, the Kasab-Kayani eco-system continues to be nurtured in Pakistan even as it is denied to Islamabad's external interlocutors, which is why 26/11 will only have partial closure.
(C. Uday Bhaskar is the former director of the New Delhi-based National Maritime Foundation. The views expressed in this column are the author's own and do not represent those of Reuters)
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18 Tie Dye Patterns for Shirts, Decor, & More
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Prayer Circles
Read Prayers. |
neverland 11/1/2007 18:09 |
Dear "Our Lady"--Our daughter went through similar acting out, which lasted on and off through her early 20s. I feel for you. My prayer: |
RandyK37922 11/8/2007 10:42 |
Our Lady, |
Has problems James J 02/12/2008
My Uncle Dennis Worthington 02/12/2008
My marriage Kat Mounce 02/12/2008
A good friends mother, who has cancer everyone who needs prayer universal 02/12/2008
Pray for Michelle and Carlos N. 07/08/2008
"This prayer is to help us sell our home."
Pray for Donald H. 07/07/2008
"The love of my life has cancer."
Pray for Amanda B. 07/06/2008
"Please pray for my daughter and her unborn child."
Pray for Janice A. 07/05/2008
"One of my most favorite people in the whole world needs your prayers today. Please spread this and include Janice in your daily prayer."
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The GNFCC's 42nd Annual Chairman's Gala, presented by Northside Hospital, will be held Sat., April 18 at The Grand Hyatt Atlanta. Sponsorship opportunities are now available.
A block of rooms has been reserved at the room rate of $159 single/double occupancy. Call 404-237-1234 today to reserve your room, and make plans to dance the night away at the GNFCC Chairman's Gala!
Thank you to all who joined us Fri., Feb. 27 at DeKalb Office for the first annual Partners in Education EXPO. North Fulton schools exhibited in an expo-styled, high-energy atmosphere and offered opportunities for partnerships to attending local businesses.
Special thanks to all our sponsors and to DeKalb Office for hosting the inaugural event!
The GNFCC welcomed John Brock, Chairman & CEO of Coca-Cola Enterprises, as our keynote speaker for the January 20 Eggs & Enterprise. Thank you to all who joined us for the special event. A special thank you to our sponsors:
The GNFCC welcomed Dr.Robert Avossa, Superintendent, Fulton County Schools, as our keynote speaker for the Feb. 24th Eggs & Enterprise.
Thank you to our sponsor:
The GNFCC will host a reception in recognition of North Fulton Day at the Capitol on March 10 at the Executive Offices of Atlanta Gas Light. Bus transportation from the GNFCC office will be provided by MARTA. This event is open to all Chamber members in good standing. RSVP required to attend.
Seating is limited on the bus, so respond today!
1.7 Million Atlanta metro adults read the AJC or visit ajc.com over 7 days
Source: Scarborough Research 2013 R1, Atlanta CBSA. Readership includes e-Edition replica.
Thank you to all who joined us on Thurs., Feb. 12 for Business After Hours hosted by Beaty Facial Plastic Surgery!
Special thanks to Dr. Mark Beaty and his team at Beaty Facial Plastic Surgery for hosting this month's event!
Save the date for North Fulton's premier business expo! The 7th ANNUAL NORTH FULTON BUSINESS EXPO is scheduled for Fri., March 27 at the Alpharetta Marriott. Booths and sponsorships are still available. Visit www.GNFCCEXPO.com for details and see who's exhibiting!
Register now to attend FREE!
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1953 Jaguar XK 120 OTS s/n 673929, Engine no. W 8316-8 Red with Tan Leather Told by the post-war government to "export or die" the British motor... More
This Jaguar has rare Borrani wire wheels. It has had the same owner past 17 years. The car was modified to run on events... More
This magnificently styled XK120 has lines and beauty way ahead of its time that begs to be driven and enjoyed. Several years ago this... More


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We are the Champions
May 22, 2012
From Left to right: Scott Garrett, Patrick Bean, John Jacobson, David Zink, and Steve Wagner.
After a long 28 week season, beginning in September, the Gibson Area Hospital (GAH) Men's Thursday Night Team claimed the championship trophy with 131 points, 16 more than their closest competitor.
GAH's team captain Patrick Bean said, "What makes this win even better, is that this is the first time in several years that GAH has had a full five man squad."
The GAH squad consisted of Patrick Bean, Steve Wagner, Scott Garrett, and first year team members David Zink and John Jacobson.
In addition to winning the championship, Steve also won Most Improved Bowler this season, increasing his average by more than 22 pins.
"As the season went along the whole team got better and that is something that really helps in a handicapped league like ours," said Bean. "I was a great season with lots of memory and we look forward to defending our trophy next season."
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Gibson Area Hospital Auxiliary Announces 2015 Scholarships
The Gibson Area Hospital Auxiliary has nine scholarships to award this year. There are two [...]
Deb Wehe Receives GAHHS Employee of the Month Award for January
Deb Wehe, of rural Foosland, was chosen as the Gibson Area Hospital & Health Services (GAHHS) [...]
The New Family Health Care of Hoopeston Opens on Dixie Highway
The Family Health Care of Hoopeston, an affiliate of Gibson Area Hospital, opened its new location [...]


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I am 26 weeks pregnant and I was in a pretty severe car crash on Friday. I was going too fast and hit some loose gravel and started fishtailing. I tried to steady the car, but in the process I ended up flipping my car and landing in a field. My car is completely totaled and it's a miracle that the baby and I seem to be ok.
I went to the ER immediately following and stayed overnight for monitoring. The baby's heartbeat and movements and everything seemed to be fine, and I was checked for placenta abruption (which I didn't have). I feel very blessed because I received a pretty hard blow to my belly which left a bruise.
My question is, being that the baby seems to be ok and the placenta is still intact, what are the chances of my baby suffering from brain damage from the accident? I am worried from the flipping, shaking, and slamming of the accident that his little brain was rattled (like shaking baby syndrome).
Does anybody know anything about this or has anybody been in an accident while pregnant and gave birth to a healthy baby?
Can a car accident while pregnant cause brain damage to the fetus?
Posted 11/06/2008


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Top 10 Baby Gifts
Now sure what to get? Use our handy guide to check out a mix of top-sellers and our most recommended products. Great for a newborn baby gift, pregnancy announcement or for a maternity leave present.
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