text:
Publications (16)15.83 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: The present study aimed to investigate the anti-depressive effect of the traditional Chinese medicine Allium macrostemon in a rat model of depression induced by exposure to chronic immobilization stress. Lipid and acylcarnitine metabolism were set into the focus of this study due to their key role in the pathogenesis of depression. Plasma lipid profiling was performed by ultra fast liquid chromatography/ion trap-time of flight mass spectrometry. Ultra-high performance liquid chromatography/triple quadrupole mass spectrometry was used to characterize the plasma acylcarnitine profile. Principal component analysis (PCA) revealed distinct differences in plasma lipid and acylcarnitine profiles of depressed rats from those in the control rats, which were also validated by univariate analysis. Several lysophosphatidylcholines (LPC (18:1→:2), LPC (20:1), LPC (O-16:2), and LPC (O-18:3)) as well as most medium- and long-chain acylcarnitines were elevated, while some phosphatidylcholines (PC (32:1), PC (36:4→:5), PC (37:4), PC (38:4→:6), PC (40:6), PC (O-36:4), and PC (O-38:5)) and triglycerides (TG (58:12), TG (60:12), and TG (62:13→:14)) were decreased in the plasma of depressed rats. These changes indicate that depressed rats were associated with inflammatory conditions and an incomplete β-oxidation of fatty acids. Most of these dysregulated metabolites were returned to their normal levels after treatment with A. macrostemon according to PCA and univariate analysis, highlighting the anti-depressive effect of this traditional Chinese medicine. These results show that liquid chromatography/mass spectrometry-based quantitative metabolic profiling method is a useful tool to investigate the metabolic changes in depression and the anti-depressive effect of traditional Chinese medicine.Journal of pharmaceutical and biomedical analysis 11/2013; 89C:122-129. · 2.45 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Qiliqiangxin capsule (QL) was developed under the guidance of TCM theory of collateral disease and had been shown to be effective and safe for the treatment of heart failure. The present study explored the role of and mechanism by which the herbal compounds QL act on energy metabolism, in vivo, in pressure overload heart failure. SD rats received ascending aorta constriction (TAC) to establish a model of myocardial hypertrophy. The animals were treated orally for a period of six weeks. QL significantly inhibited cardiac hypertrophy due to ascending aortic constriction and improved hemodynamics. This effect was linked to the expression levels of the signaling factors in connection with upregulated energy and the regulation of glucose and lipid substrate metabolism and with a decrease in metabolic intermediate products and the protection of mitochondrial function. It is concluded that QL may regulate the glycolipid substrate metabolism by activating AMPK/PGC-1 α axis and reduce the accumulation of free fatty acids and lactic acid, to protect cardiac myocytes and mitochondrial function.Evidence-based Complementary and Alternative Medicine 01/2013; 2013:378298. · 2.18 Impact Factor -
Article: [Effects of tongxinluo on angiogenesis and the volume of blood perfusion in ischemic stroke rats].
[Show abstract] [Hide abstract]
ABSTRACT: To observe the effects of Tongxinluo (TXL) on angiogenesis and the volume of blood perfusion in ischemic stroke rats. The model of middle cerebral artery occlusion (MCAO) was established using craniotomy ligation of the middle cerebral artery on one side. After screening, the male SD rats were randomly divided into the sham-operation group, the model group, the large dose TXL group, the middle dose TXL group, the low dose TXL group, and the Nimodipine group. The expression of microvascular density (MVD, CD31) of the MCAO rats was detected using immunohistochemical assay after 14 days of medication. The microvascular morphology and the volume of blood perfusion in the brain tissue were observed under laser scanning confocal microscope (LSCM). The positive CD31 expression was intense with significant coloring in the large dose TXL group, the middle dose TXL group, and the Nimodipine group, better than that of the model group. The blood perfusion volume in the ischemic brain cortex could be promoted in the large dose TXL group, the middle dose TXL group, and the Nimodipine group (P<0.01, P<0.05). The optimal effects were shown in the large dose TXL group (P<0.01). TXL significantly increased the MVD of the ischemic brain tissue, promoted the post-ischemic angiogenesis, and increased the volume of blood perfusion of ischemic brain tissue, playing certain blood flow compensatory roles.Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 12/2012; 32(12):1667-70. - [Show abstract] [Hide abstract]
ABSTRACT: To investigate the effects of exhaustive swimming exercise on P2X1 receptor- and α1-adrenoceptor-mediated vasoconstriction of different types of arteries in rats. Male Wistar rats were divided into 2 groups: the sedentary control group (SCG) and the exhaustive swimming exercise group (ESEG). The rats in the ESEG were subjected to a swim to exhaustion once a day for 2 weeks. Internal carotid, caudal, pulmonary, mesenteric arteries and aorta were dissected out. Isometric vasoconstrictive responses of the arteries to α,β-methylene ATP (α,β-MeATP) or noradrenaline (NA) were recorded using a polygraph. The exhaustive swimming exercise did not produce significant change in the EC(50) values of α,β-MeATP or NA in vasoconstrictive response of most of the arteries studied. The exhaustive swimming exercise inhibited the vasoconstrictive responses to P2X1 receptor activation in the internal carotid artery, whereas it reduced the maximal vasoconstrictive responses to α1-adrenoceptor stimulation in the caudal, pulmonary, mesenteric arteries and aorta. The rank order of the reduction of the maximal vasoconstriction was as follows: mesenteric, pulmonary, caudal, aorta. Exhaustive swimming exercise differentially affects the P2X1 receptor- and α1-adrenoceptor-regulated vasoconstriction in internal carotid artery and peripheral arteries. The ability to preserve purinergic vasoconstriction in the peripheral arteries would be useful to help in maintenance of the basal vascular tone during exhaustive swimming exercise.Acta Pharmacologica Sinica 02/2012; 33(2):221-9. · 2.35 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: Hyperlipidemia (HL) and unstable angina (UA) are two sequential diseases that cause more and more morbidity and mortality world-wide. Biomarkers selection in the level of physical and chemical specifications (PCS) plays a key role in understanding the pathology of both diseases. Neuro-Endocrine-Immune (NEI) system is a preferable pathway to investigate the interaction network of related PCS in the context of HL and UA. Data mining approaches are a kind of advanced statistical methods to unravel the "secret" of interaction network of PCS in both diseases. Feature selection methods are a branch of data mining approaches to select informative subset of PCS as biomarkers to distinguish a disease from healthy control cohort with high classification accuracy. In this paper, we firstly use three feature selection methods combined with decision tree classification algorithm to select several biomarkers from NEI network. The results show that SVM based decision tree is best fit to select biomarkers for both diseases. Furthermore, we use the theory from Traditional Chinese Medicine (TCM) to divide HL and UA patients into two subgroups. Based on this, we propose a novel feature selection method to distinguish the two subgroups. We combine variance analysis with classification method to select three to four biomarkers for two subgroups in the context of HL and UA respectively, which means that NEI specifications behave differently between two subgroups. According to basic theory of TCM, variant subgroups defined by TCM need to be treated differently. It means that patients with the same disease may be treated in a personalized way. The research efforts in the paper not only to provide a better avenue to understand the nature of diseases, but also to pave a basis to treat two diseases in a personalized way.Journal of Biological Systems 11/2011; 18(03). · 0.96 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To observe the ultrastructure changes of cerebral cortex neuron and endothelial cell in hypoxia preconditioning mice and the effects of Tongxinluo (TXL, Chinese traditional medilihe) on them. Mice were randomly divided into 4 groups: control group, hypoxia group, hypoxia preconditioning (HP) group and Tongxinluo (TXL) group. The hypoxia preconditioning mice were exposed by repetitive hypoxia for 5 runs. The animal's tolerance time of each hypoxia run was recorded. The ultrastructure change of cerebral neuron and endothelial cell were studied by electron microscope. The hypoxic tolerance time in HP and TXL groups were significantly increased run by run. Compared with HP group, the tolerance time of TXL group were increased in every run. The ultrastructure of cerebral neuron and endothelial cell in hypoxia group changed obviously, mitochondrion and endoplasmic reticulum destroyed. However they were slighter in HP group than those in hypoxia group. The change in TXL group had no obvious differentce with control group and were slighter than those in HP group. Hypoxia preconditioning shows that organism has a strong self-repairing ability. Tongxinluo self-repairing; could increase self-repairing ability and adaptive ability of mice to hypoxia obviously.Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 11/2011; 27(4):396-9. - [Show abstract] [Hide abstract]
ABSTRACT: Excess fatigue is a pathological state of continuing accumulation of fatigue, which may cause the deterioration of body health, occurrence of diseases, and even lead to death. A metabonomics study was performed on the excess fatigue rats treated with traditional Chinese medicine Tongxinluo or ginseng based on ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC-IT-TOF-MS). The plasma metabolic profiling data of the control rats, excess fatigue rats, and excess fatigue rats treated with Tongxinluo or ginseng were acquired. The orthogonal partial least squares analysis (OPLS) was applied for the multivariate statistics and the discovery of important differential metabolites distinguishing the excess fatigue rats treated with Tongxinluo or ginseng from the control rats and excess fatigue rats. The results showed tryptophan, bile acid, lysophosphatidylcholine metabolism were disturbed in the excess fatigue rats. The metabolic pattern including the related metabolic pathways of the rats, being treated with Tongxinluo or ginseng, was adjusted towards the normal state.Se pu = Chinese journal of chromatography / Zhongguo hua xue hui 11/2011; 29(11):1049-54. - [Show abstract] [Hide abstract]
ABSTRACT: A urinary metabonomic method based on ultra-fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was employed to study the preventive efficacy and the metabolic changes caused by simavastatin and the traditional Chinese medicine tongxinluo in endothelial dysfunction rats. Principal component analysis (PCA) was applied to study metabolic patterns of endothelial dysfunction rats and healthy control rats. 1-Methyladenosine, indoxyl sulfate, hippuric acid, riboflavin, coproporphyrin, and p-cresol glucuronide were identified as potential biomarkers, indicating that pathways of adenine, tryptophan, phenylalanine, riboflavin and porphyrin metabolism were disturbed in endothelial dysfunction rats. Applications of simvastatin and tongxinluo to endothelial dysfunction rats improved endothelial function according to the results of histopathology and measurements of endothelin-1 and nitric oxide. Metabonomic studies suggested that tongxinluo prevents endothelial dysfunction by regulating multiple metabolic pathways to their normal state, whereas simvastatin only altered selected metabolic pathways. This research demonstrated that metabonomics is a powerful and promising tool for disease investigation and the efficacy evaluation of complex traditional Chinese medicines.Journal of pharmaceutical and biomedical analysis 08/2011; 56(1):86-92. · 2.45 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: P2X(1) receptors, the major subtype of P2X receptors in the vascular smooth muscle, are essential for α,β-methylene adenosine 5'-triphosphate (α,β-MeATP)-induced vasoconstriction. However, relative physiological significance of P2X(1) receptor-regulated vasoconstriction in the different types of arteries in the rat is not clear as compared with α(1)-adrenoceptor-regulated vasoconstriction. In the present study, we found that vasoconstrictive responses to noncumulative administration of α,β-MeATP in the rat isolated mesenteric arteries were significantly smaller than those to single concentration administration of α,β-MeATP. Therefore, we firstly reported the characteristic of α,β-MeATP-regulated vasoconstrictions in rat tail, internal carotid, pulmonary, mesenteric arteries, and aorta using single concentration administration of α,β-MeATP. The rank order of maximal vasoconstrictions for α,β-MeATP (E (max·α,β-MeATP)) was the same as that of maximal vasoconstrictions for noradrenaline (E (max·NA)) in the internal carotid, pulmonary, mesenteric arteries, and aorta. Moreover, the value of (E (max·α,β-MeATP)/E (max·KCl))/(E (max·NA)/E (max·KCl)) was 0.4 in each of the four arteries, but it was 0.8 in the tail artery. In conclusion, P2X(1) receptor-mediated vasoconstrictions are equally important in rat internal carotid, pulmonary, mesenteric arteries, and aorta, but much greater in the tail artery, suggesting its special role in physiological function.Purinergic Signalling 05/2011; 7(2):221-9. · 2.64 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To investigate the effect of fatigue and restraint stress on the expressions of CPT (carnitine palmitoyltransferase)-I, PPAR (peroxisome proliferator-activated receptor) δ, 5-HT (hydroxytryptamine) 1D and 5-HT2A receptors in aorta of rats. A total of 45 healthy male Wistar rats were randomly divided into control group, excessive fatigue group and restraint stress group (n = 15 each). The general condition, morphological changes of aortic endothelium cell and the blood levels of ET-1 (endothelin) and NO (nitric oxide) were observed. The real-time reverse transcription PCR (polymerase chain reaction) and Western blot were used to detect the gene and protein expressions of CPT-I, PPAR δ, 5-HT1D and 5-HT2A receptors in aorta. Compared with control group, the structural damages of endothelial cell were induced by excessive fatigue and restraint stress. The plasma levels of ET-1 increased [(124 ± 18) ng/L vs (161 ± 18) ng/L, (154 ± 17) ng/L] (P < 0.01, P < 0.05) while the serum levels of NO decreased [(63 ± 16) µmol/L vs (39 ± 8) µmol/L, (41 ± 7) µmol/L] (P < 0.05); the mRNA expressions of CPT-Iand PPARδ decreased in excessive fatigue rats, [(1.23 ± 0.21) vs (0.42 ± 0.05)], [(1.09 ± 0.10) vs (0.25 ± 0.07)] (P < 0.01); the protein expressions of CPT-Iand PPARδ decreased in excessive fatigue rats, [(1.32 ± 0.07) vs (0.83 ± 0.04)], [(1.41 ± 0.05) vs. (0.75 ± 0.06)]; the mRNA and protein expressions of 5-HT1D receptor decreased in excessive fatigue rats and restraint stress rats, [(1.10 ± 0.15) vs (0.46 ± 0.13), (0.45 ± 0.02)], [(1.19 ± 0.05) vs (0.71 ± 0.06), (0.70 ± 0.05)] (P < 0.01); the mRNA and protein expressions of 5-HT2A receptor increased in excessive fatigue rats and restraint stress rats, [(0.99 ± 0.08) vs (6.73 ± 0.46), (7.01 ± 1.56)], [(0.64 ± 0.03) vs (0.79 ± 0.05), (0.82 ± 0.03)] (P < 0.01). Excessive fatigue and restraint stress can injure the structure and function of endothelial cell. The changes in energy of abnormal carnitine metabolism and 5-HT receptors may play important roles.Zhonghua yi xue za zhi 04/2011; 91(13):915-9. - [Show abstract] [Hide abstract]
ABSTRACT: To observe the changes of vascular endothelial functions and general neuro-endocrine-immunity (NEI) network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness. A total of 100 male Wistar rats were randomly divided into the control group and the qi-deficiency syndrome model group, 50 rats in each group. The qi-deficiency syndrome model was established by feeding the animals with hyper-alimentation diet in combination with restricting movement for 10 weeks. Changes of common chemical signal molecules related to NEI and vascular endothelial functions were measured by the end of the experiment. Furthermore, their internal relevance was analyzed by the method of canonical correlation analysis. The vascular endothelial structure and function were obviously injured in the model group. Compared with the control group, the chemical signal molecules, such as 5-hydroxytryptamine (5-HT), corticosterone (CORT), triiodothyronine (T3), tetraiodothyronine (T4), angiotensin II (Ang II), interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-alpha) in peripheral blood of the model group (n=43) were changed significantly (P<0.05 or P<0.01). Canonical correlation analysis showed that vascular endothelial dysfunction was correlated to the changes of these signal molecules in the NEI network. Comfort-based lifestyle induced not only vascular endothelial dysfunction but also an imbalance of the NEI network. Vascular endothelial dysfunction and the imbalanced NEI network interacted with each other, and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction, even diseases of the blood vessel.Chinese Journal of Integrative Medicine 02/2010; 16(1):54-60. · 1.40 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To cultivate human umbilical vein endothelial cells (HUVECs) in the serum of overfatigue rats with the intervention of Tongxinluo superfine powder (TXLSP). By examining the variation of the activity of JNK/c-Jun/HO-1 pathway, the possible mechanisms of vascular endothelial dysfunction under overfatigue conditions and the intervening effect of TXLSP were explored. The HUVECs were randomly divided into the normal control group, the model group, the SP600125 (a specific antagonist of JNK) group, the TXLSP group and the TXLSP + SP600125 group. The content of carboyhemoglobin (COHb) and the leak rate of lactic dehydrogenase (LDH) in different groups were measured. The mRNA and protein expression of JNK, c-Jun, HO-1 and the phosphorylation level of c-Jun (P-c-Jun) were detected using Western blot and PCR methods. Compared with the normal control group, the COHb level in supernatant was increased significantly in the model group, and the expression of HO-1, JNK, c-Jun mRNA and corresponding proteins and P-c-Jun were also increased remarkably. The increases in these parameters were significantly decreased by SP600125. TXLSP showed remarkable up-regulation on the expression of JNK, c-Jun, P-c-Jun and HO-1 mRNA and their protein expression. Compared with the SP600125 group, the expressions of JNK, c-Jun, P-c-Jun and HO-1 mRNA and its protein in the TXLSP+SP600125 group were significantly increased at different time points (P<0.05, P<0.01). The vascular endothelial dysfunction under overfatigue conditions is related to the activity of the JNK/c-Jun/HO-1 pathway. One of the mechanisms of TXLSP in improving the vascular endothelial function is to adjust the activity of the JNK/c-Jun/HO-1 pathway at gene and protein levels.Chinese Journal of Integrative Medicine 04/2009; 15(2):121-7. · 1.40 Impact Factor -
Article: [The endothelium injuries caused by homocysteine and treatmental effects of Tongxinluo powder].
[Show abstract] [Hide abstract]
ABSTRACT: To observe the effect of homocysteine (HCY) on the function of endothelium cell, and to discuss the possible mechanisms that Tongxinluo super powder affected. Healthy male Wistar rats were divided into randomly the control group, the model group, the Tongxinluo group. The effect of Ach on isolated rat thoracic aorta in vitro was examined, the microcirculation was observed by microcirculation meter, the activity of SOD and GSH-PX and content of NO, MDA, ET, Ang II, TXA2, PGI2 was detected. Compared with control group, the effect of Ach on isolated rat thoracic aorta in vitro weakened markablely (P < 0.01), the format and percentage that capillary dilated declined significantly (P < 0.05), after treatment with Tongxinluo powder, the effect of Ach on isolated rat thoracic aorta in vitro was improved obviously (p < 0.01), and the format and percentage that capillary dilated were increased compared with model group; comparing with the control group, the level of Ang II and ET, TXA2 in plasm increased obviously (P < 0.05, P < 0.01), while the content of PGI2 depressed manifestly (P < 0.05), at the same time, both content of NO and activity of SOD, (GSH-PX declined obviously (P < 0.001, P < 0.05). After treatment with Tongxinluo powder, the level of ET, AngII and TXA2 reduced significantly in different degree (P < 0.01), while the content of PGI2 appeared stepping up notably (P < 0.01), and both activity of SOD and NO level increased obviously (P < 0.01, P < 0.05). (1) The high homocystein might cause the contracted and dilated function decreased, it might get involved in endothelium disfunction as a result of the massive free radicals production and diastolic-contract factors balance disorder induced by high homocystein. (2) Tongxinluo powder could improve the function of endothelium-dependment dilation induced by high homocystein, that associated with inhibitting the excessive production of free radicals, and improved function of endothelium.Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 02/2008; 24(1):66-70. - [Show abstract] [Hide abstract]
ABSTRACT: To explore the pathogenesis characteristics of variant angina pectoris (VAP) by extracting its syndrome elements and analyzing the combination and distribution regularity of the syndrome elements. One hundred and seventy-five case files of VAP patients were collected. The extraction of syndrome elements and symptom contribution to syndrome was completed by the partition method of complex system based on entropy theory. Diagnostic threshold was established by receiver operator characteristic curve. According to the results diagnosed by diagnostic criteria for syndrome element with quantitation, the combination and distribution regularity of the syndrome elements in patients with VAP was analyzed. The basic syndrome elements in the patients with VAP were qi deficiency, qi stagnation, blood stasis, phlegm turbidity, phlegm-heat, stagnation-heat, yin deficiency and yang deficiency syndromes. It showed that the combination types of syndrome elements could be made up of one syndrome, two, three, four or more than four syndromes. Qi deficiency, yin deficiency, qi stagnation, blood stasis and phlegm turbidity syndromes had the higher frequency than other syndrome elements in the patients with VAP. The partition method of complex system based on entropy theory can be used in extracting the syndrome elements of the patients with VAP. It is found that VAP has complicated pathogenesis according to the combination and distribution regularity of syndrome elements. Qi deficiency, qi stagnation, blood stasis, phlegm turbidity and yin deficiency syndromes are the main syndrome elements.Journal of Chinese Integrative Medicine 12/2007; 5(6):616-20. - [Show abstract] [Hide abstract]
ABSTRACT: To investigate the effect of Tongshenluo Capsule (TSL) on the components of extracellular matrix (ECM) and their metabolism in kidney of rats with diabetic nephropathy (DN), and to explore its mechanism of kidney protecting. The DN model rats established by one side nephrectomy and intraperitoneal injection of streptozotocin were randomly divided into 5 groups, the sham-operation group, the model group, the Valsartan group, the Gliquidon group, and the TSL group, 10 in each group. Levels of fasting blood glucose (FBG) and 24-h urinary micro-content of albumin (24 h mAlb) were determined dynamically; the serum glycosyl hemoglobin (HbA1c)was determined after the last medication; the ultrastructural changes of kidney were observed by transmission electron microscope; the expressions of collagen IV (IV-C), fibronctin (FN), laminin(LN), and the ECM metabolism influencing factors, including MMP-2, tissue inhibitor of metalloproteinase (TIMP-2), transfer growth factor-beta1 (TGF-beta1) in renal tissue were detected by immunohistological chemistry and image collecting analytical system. Results TSL could decrease the levels of FBG, HbA1c, 24 h mAlb (P < 0.05 or P < 0.01), ameliorate the thickness of glomerular basement membrane (GBM), decrease the components of ECM, down-regulate TGF-beta1 and TIMP-2 expression, and up-regulate MMP-2 expression (P < 0.05 or P < 0.01). TSL plays a role of kidney protection by decreasing the ECM components expression and regulate ECM metabolism.Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 05/2007; 27(4):326-30. - [Show abstract] [Hide abstract]
ABSTRACT: To observe the effects of Tongxinluo Supermicro Powder on the nuclear factor-kappaB (NF-kappaB), inter-cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) expression in aorta of rabbits fed with high-lipid diet. Healthy male New Zealand rabbits were randomly divided into 4 groups (n = 8 each): control group, model group, atorvastatin group (3 mg x kg(-1) x d(-1) per gavage), and Tongxinluo group (0.31 g x kg(-1) x d(-1) per gavage). At the end of 6 weeks, the expression of NF-kappaB, ICAM-1 and VCAM-1 were observed by immunochemistry methods, Western blotting and reverse transcription polymerase chain reaction (RT-PCR). The nuclear translocation of NF-kappaB in aortic endothelial cells and the gene expressions of NF-kappaB, ICAM-1 and VCAM-1 at protein and mRNA levels of the model group was significantly increased compared that in the control group (all P < 0.05), these effects could be significantly attenuated by atorvastatin and Tongxinluo Supermicro Powder (P < 0.01 vs. model group). Similar as atorvastatin, Tongxinluo Supermicro Powder could relieve the process of atherosclerosis by decreasing the nuclear translocation of NF-kappaB and reducing the expression of ICAM-1, VCAM-1 in this model.Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] 04/2007; 35(3):271-4.
Publication Stats
34 | Citations | |
15.83 | Total Impact Points | |
Top Journals
China Academy of Traditional Chinese Medicine
Peping, Beijing, China
Hebei Medical University
Chentow, Hebei, China -
Dalian Institute of Chemical Physics
Lü-ta-shih, Liaoning, China


text:
We wish we could have seen her professor's face when she turned in this assignment.
A+ for effort, though.
A private Lutheran school in Texas is facing a media firestorm over forcing 17-year-old Austin Wallis to leave.
Meet your new dad, Detective Worm. He's something of a cad. But still pretty rad.
The literary grande dame thinks To Kill a Mockingbird is just overrated YA. She's half-right.

subset: commoncrawl


text:
I'm an outgoing female who loves to have a good time and just be
around good friends. I value honesty probably above everything
else, if your not keeping it real then keep it movin because I
don't have time for BS. I'm looking for someone who can be straight
forward, but also has a great sense of humor because I love to
laugh. Don't be hitting me up for no bootycalls.. etc. I'm not
interested in anything like that. In general I just like to go out,
shoot pool, go to the beach, and just hang out. I love trying new
restaurants and foods and would love to have someone try it with me
I am silly, exuberant, and sympathetic
I am silly, exuberant, and sympathetic


text:
Launcher Update
Get the Desktop App for Battle.net Now
- All your games in 1 place
- Log in once
- Automatic game updates
hi my names infamousevil a friend of mine braught a clan from another server we are currently lvl 9 and looking for friendly members of all types. we just like too chill and have fun. all will be getting MOP. if ur looking for a friendly chill guild PST InfamousEvil or reply here. can also add my battletag, InfamousEvil
oh can add me on skype too InfamousEvil1
lvl 10 now! pst me if u wanna join
Threats of violence. We take these seriously and will alert the proper authorities.
Posts containing personal information about other players. This includes physical addresses, e-mail addresses, phone numbers, and inappropriate photos and/or videos.
Harassing or discriminatory language. This will not be tolerated.


text:
Good Morning Challengers!
As some of you may notice, I'm the new Administrator. Its been an interesting past month, so take a moment to thank KaLin and all the Mods for all their hard work during the interim. But it's May 1st, which means it's time for our fourth monthly check-in thread (though technically this is my first).
You've paid your taxes at this point, and some have already received a refund. How has the tax season affected your finances? Did April impact your goals, or are you happy for the new month and the new opportunities? Achieve any financial landmarks, or hit any dips along the way?
As always, let us know how you're doing! What have been your biggest accomplishments and obstacles so far in the myFICO Fitness Challenge for 2013? We're almost halfway done, so keep at it, and let's all cross together.
As a reminder, participation in these monthly check-ins is optional, but encouraged. The goal is to help keep you on track, so feel free to post your progress updates here.
I'm broke but all the bills are paid! Have a kid graduating high school this month and getting ready to start college. Oh what hectic times.
I'm doing quite well! Trying to wrap up my old job before I take six months off to study for the CPA exam and re-start some of my own businesses.
One odd thing that happened: An old BofA Platinum Plus card that went into a Payment Plan suddenly resurfaced as an active credit card after I paid it in full! This is really great, since it's an old account...don't have to worry as much about AAoA dropping in the future.
I'm just waiting for one last TL to report PIF as well as some paperwork to delete a TL with a baddie before going to app for an AMEX card I'm lusting after.
I'm tracking my score changes in a thread over here....no news lately!
I just got approved for a mortgage!!! YES! I didn't think that was possible when I started this journey in January, yes you read that right! I don't even know what my scores were in January for sure but i know they were all below the 580 mark. My credit report work is almost done. I have obtained several new credit cards (I haven't had a credit card in 10 years!) and I have been approved for a total of $12000 in installment loans. I'm very thankful for this board and all the advice I've found on here from people who have done this before me. I'm even more grateful when I know I could have spent $$$ on having someone else do my 'credit repair' for me. I wish everyone a wonderful May!!!!
Woo hoo! Congrats LdyNRed!
Just received my 2008 refund, waiting for the rest of my 2010 refund, and have to file my 2012 taxes (getting a refund). But since I need to change of address, the IRS said to wait, because at filing time, they still owed me money from 2008 & 2010 & 2011. So got two out of the three. Thinking of biting the bullet and filing 2012 with a change of address despite that they still owe me some money.
Just learned that I may take on four more dependents while my youngest is trying so hard to be financially independent in first year of college.
But no complaints - we work hard to be here.
lol - I did almost tell off a high pressured sales man and his assistant that it's hard to be cash only! They both said, take out a loan, do the bill me later, take out a mortgage, write a check that would bounce, do a cash advance off of a cc, do a balance transfer from a cc, call someone for the money...and I said no. I have no method to pay for the purchase, therefore I would not be purchasing.
Ya know, it takes some effort to be cash only! They have no idea...
I'm up to 655 (from 618 in February) on my Equifax. Hoping it goes up a little more mid-month when my credit card statement posts at $0.00 balance instead of the $20.00 balance (300 limit) it showed last month.
Its May 3rd and here's my May check-in. My Credit score is 640 . My cc both have zero balances. I was able to put away $500 this month in a savings account. My goal is to save until I get $3000 and then borrow against it as a Personal Loan. I open my savings account with my Credit Union. I also was able to payoff and have a collection account deleted. I haven't applied for any credit since January. My May goal is to have my last Collection account paid and work on having it deleted. I think I'm on my way.
Thanks for the endless advise and support. Back to the garden
Copyright ©2001-2015 Fair Isaac Corporation. All rights reserved. | Terms of Use | Privacy Policy | Sitemap
IMPORTANT INFORMATION: All FICO® Score products made available on myFICO.com include a FICO® Score 8, along with additional FICO® Score versions based on Experian or Equifax data (additional FICO® Score versions based on TransUnion data are not currently available on myFICO.com). Your lender or insurer may use a different FICO® Score than the versions you receive from myFICO, or another type of credit score altogether. Learn more
FICO, myFICO, Score Watch, The score lenders use, and The Score That Matters are trademarks or registered trademarks of Fair Isaac Corporation. Equifax Credit Report is a trademark of Equifax, Inc. and its affiliated companies. Many factors affect your FICO Score and the interest rates you may receive. Fair Isaac is not a credit repair organization as defined under federal or state law, including the Credit Repair Organizations Act. Fair Isaac does not provide "credit repair" services or advice or assistance regarding "rebuilding" or "improving" your credit record, credit history or credit rating. FTC's website on credit.


text:
Changes related to "Wiktionary:Word of the day"
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category). Pages on your watchlist are bold.
28 February 2015
- (diff | hist) . . Wiktionary:Word of the day/Nominations; 18:26 . . (+175) . . I'm so meta even this acronym (Talk | contribs) (→Latest nominations)


text:
The voice of the BlackBerry community.
[ad#Google Adsense]
Post Comment
Awww this is on the money in so many ways.
lmfaoooo. so true! Team Blackberry here!
Bullseye! heheheh
FREE OMG 1031$ FREE I just won Just just by having this in my computer http://bit.ly/winzhz its really a surprise gift in tough times
I thought they will not but when i saw the 1031 in account i am really surprised its working
You to try it and have assured gift .i just recieved


text:
Home |
Pair Of Early 19th C. Chinese Soapstone Seal stamp browse these categories for related items... All Items: Antiques: Regional Art: Asian: Chinese: Scholar Art: Pre 1837 VR: item # 1186465 Please refer to our stock # G0627 when inquiring.
Asian Art Online 5942 Edinger Avenue, Suite 113 , PMB 109 Huntington Beach, CA 92649, USA 714-846-8913 Guest Book |
$850 (Holding) A set of beautiful very old 19th C. Chinese scholar soapstone seal in excellent patina and condition. H:6cm $850 |


text:
The company expects its mobile site to launch by the end of this year and is investing 'seven figures' into additional digital initiatives.
If mobile websites included a click-to-order button that routed customers to a geolocation API, the brands' mobile experiences would be better suited to handle each query.
The company spent three years testing ingredients, operations and ovens, and has experienced a sizable comp lift since adding pizza to its brand positioning.
Wheat prices closed below the $6 mark twice last week, plunging to $5.68 on Friday.
The word 'fresh' is the most powerful driver of menus because it has a connotation that it is real food being served.
Gas prices have stayed steady for the past two weeks, despite a busy holiday weekend.
The brand is aiming for 25 locations in the next year, including a debut in the Midwest and New York.
Gas prices continued to fall through the busy Labor Day holiday weekend.
A selfie that includes your restaurant, food or drink is a perfect form of implied testimonial.
The company is in the midst of a new POS rollout that is expected to drive labor efficiencies, speed of service and order accuracy.
An abundance in refinery production is keeping gas prices in check.
The National Restaurant Association claims the decision will impede job creation and create 'big business.'
Wheat is down more than 40 cents in two weeks.
Offer customers something, like a discount or a recipe, in return for their like.
With the concept, the company has increased two stores' business by about 15 percent without adding much labor.
Yum! execs called the U.S. performance 'disappointing' and said the brand is in turnaround mode.
Mobile is now the dominant channel of Pizza Hut's digital business, growing more than 4,000 percent in the last three years.


text: Image text transcribed for accessibility: A jot fighter pilot knows he is able to withstand an acceleration of 9g. The pilot points his plane vertically down while traveling at March 3 speed and intends to pull up in a circular maneuver before crashing into the ground, Where does the maxi mu m acceleration occur in the maneuver? What is the mini mu m radius the pilot can take? (circle smaller than this will result m pilot blackout.)


text:
Human Fertility Treatments Help Give Rhinos a Leg Up
Byline: LYNNE KELLEHER
THEIR horns are supposed to have amazing aphrodisiac effects, but Dublin Zoo is having to use human fertility treatments to help their rhinos conceive.
Artificial insemination and hormone treatment are two of the 21st Century fertility practices being used to help the female rhinos become pregnant.
In 2008, rhino Ashanti gave birth to a female calf called Zuki but the other two females in the herd, Zanta and Leni, have yet to become mothers.
White rhinos are prone to fertility problems so now vets are turning to human medical methods like hormone treatment and IVF.
One of the world leading experts on rhino fertility, Robert Hermes, has travelled to Dublin Zoo to carry out ultrasounds and electro-ejaculation on the herd of southern white rhinos.
African Plains headkeeper Helen Clarke-Bennett said: "We have a young female who has never shown any signs of coming in oestrus, meaning that she is ready to mate.
"We have an old female who regularly comes in oestrus, but neither male has been able to get her pregnant.
"As female rhinos get older they run into terrible problems within their reproductive tract. Therefore at this moment time is of an essence. " German zoologist Robert Hermes said: "The first thing we look at is the male. …
The rest of this article is only available to active members of Questia
Sign up now for a free, 1-day trial and receive full access to:
- Questia's entire collection
- Automatic bibliography creation
- More helpful research tools like notes, citations, and highlights
- A full archive of books and articles related to this one
- Ad-free environment
Already a member? Log in now.


text:
Welcome to Fashiolista! Discover, save & share the greatest fashion findsfrom anywhere on the web! Sign in with Facebook
Find it here 9 First found by Stephanievos at lystit.com 2 years, 11 months ago @Tag a friend Add to list comments Please sign in to start gossiping Sign in with Facebook or sign up manually There's no gossip yet... Are you sure you want to delete this comment? Cancel Are you sure this is spam? Cancel we love it! (9) tags for this item beige high heel leather lizzard nude plateau platform sandals shoe smakeskin strappy sandals suede YSL Yves Saint Laurent login to add tags


text:
Dictionary » I » Indurative IndurativeIndurative Pertaining to, causing, or characterised by induration. Please contribute to this project, if you have more information about this term feel free to edit this page
This page was last modified 21:16, 3 October 2005. This page has been accessed 650 times. |
© Biology-Online.org. All Rights Reserved.
Register | Login
| About Us | Contact Us | Link to Us | Disclaimer & Privacy | Powered by CASPION


text:
229 Rio Del Mar Blvd, Rio Del Mar / Seascape, CA
3 bedrooms2 baths
This two-story beach home takes full advantage of the spectacular stretch of coastline that unfolds outside its many windows. Stretching across th...
Read More
338 Treasure Island Dr, Rio Del Mar / Seascape, CA
3 bedrooms2 baths
Expansive ocean views from this charming Mediterranean home. 4 blocks to the beach, this is the perfect vacation or beach getaway. Built in the 193...
Read More
Office Properties
781 Via Gaviota, Rio Del Mar / Seascape, CA
4 bedrooms5 baths
Expansive Ocean and Bay Views of miles of endless Sandy Beaches. Custom built with 4 Bedrooms and 5 full baths. Spacious dining areas, kitchen wit...
Read More


text:
- 18/02/2015 - FAO will provide food crop seeds, animal feed and drip irrigation equipment to help thousands of people in Cabo Verde whose food security and livelihoods are at risk following a ...read more
Latest Stories
- 25/08/2014 - Ban Ki-moon's newly appointed-Senior UN Systems Coordinator for Ebola, Dr. David Nabarro, on a two-day visit in Monrovia, last week, said there is a need for urgent measures to be ...read more
- 19/08/2014 - 19 August marks the anniversary of the bombing of the United Nations headquarters in Baghdad, in which 22 people lost their lives. In 2008, the UN General Assembly designated this ...read more
- 14/08/2014 - The fighting in Gaza has forced farmers and herders to abandon their lands and has paralysed fishing activities, bringing local food production to a halt and severely affecting livelihoods, FAO warned today. ...read more
- 31/07/2014 - Continued efforts to provide farmers, fishers and pastoralists in South Sudan with life-saving emergency livelihood kits are at risk due to a funding shortfall, aggravating the risk of famine in some areas of ...read more
- 25/07/2014 - The European Union (EU) will partner with FAO to help small-scale farmers in Serbia recover from the devastating floods of the past spring. An EU grant of EUR 8 million, ...read more
- 25/07/2014 - The United Nations today called on the international donor community to renew a commitment to fight hunger and food insecurity in the Sahel by protecting and strengthening the resilience of ...read more
- 21/07/2014 - Increased efforts are needed to improve awareness among rural communities in West Africa about the risks of contracting the Ebola virus from eating certain wildlife species including fruit bats, FAO ...read more
- 26/06/2014 - Iraq is facing serious food security concerns following the recent escalation of conflict in a large swath of the country, FAO warned today. Over 1 million people so far have ...read more
- 05/06/2014 - FAO is scaling up its emergency response operations in South Sudan despite problems of access and insecurity in parts of the country. The Organization has extended its emergency response for an additional three ...read more
- 02/06/2014 - Late rains and erratic weather patterns in Somalia have raised concerns over a worsening of the food security situation, as food stocks from the last, poor harvest become depleted and prices continue ...read more


text:
steam train posters, steampunk posters, photorealism posters, railway posters, train posters, locomotive posters, steam posters, gwr posters, 1950 posters, station posters
All prints ship in durable cardboard tubes.
Fine Art America is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality posters and prints. All of our posters are produced on state-of-the-art, professional-grade Epson printers.
We use acid-free paper with archival inks to guarantee that your posters last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Posters ship within 3 - 4 business days in durable cardboard tubes.
THIS PAINTING IS SOLD BUT YOU TOO CAN COMMISSION MIKE TO PAINT YOUR VERY OWN ORIGINAL OF YOUR FAVOURITE STEAM LOCOMOTIVE EITHER BRITISH OR AMERICAN, A SOUND INVESTMENT FROM WHOM MANY REGARD AS BRITAIN'S LEADING TRANSPORT ARTIST. JUST E-MAIL email@example.com her cylinder cocks open ex-GWR Castle Class 5058 �Earl of Clancarty� has the �Right away� with a Down express sometime in the 1950s. The beautiful condition of the locomotive is typical of the Western region of British Railways at the time when little had seemed to change after Nationalisation of the railway since the days of the Great Western Railway and men still carried the pride they felt in that company. A painting like this of your...
COMMISSION A PAINTING FROM MIKE. Virtually nobody considered the humble lorry worthy of the subject of a painting until Mike made it so. Years of being at the sharp end of long distance HGV driving has given him an insight and knowledge into the industry that enables Mike to depict lorries as they really were in the past and not the idealized view of the less knowledgeable making him the man to paint an original of your favourite commercial vehicle. He is without a doubt THE lorry artist. Mike�s first-hand knowledge of buses as a PSV driver for over forty years gives this area of his work a stamp of authenticity and knowledge of the industry so consequently his depictions of buses and coaches have set a standard that others follow....
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
If you've hesitated to purchase artwork online in the past, why not give us a try? You have nothing to lose!
We take great pride in the fact that 297,017 artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
Customer Service: 877-807-5901
(Call Any Time - 24 Hours Per Day)
All posters ship from our production facility within 24 hours of your order.
Please Wait...


text:
Obama To Nominate Yellen As Bernanke Successor
By MARTIN CRUTSINGER and JIM KUHNHENN
WASHINGTON (AP) â¿¿ President Barack Obama will nominate Federal Reserve vice chair Janet Yellen to succeed Ben Bernanke as chairman of the nation's central bank, the White House said Tuesday. Yellen would be the first woman to head the powerful Fed, taking over at a pivotal time for the economy and the banking industry.
Both Yellen and Bernanke are scheduled to appear with Obama at the White House on Wednesday for a formal announcement.
Bernanke will serve until his term ends Jan. 31, completing a remarkable eight-year tenure in which he helped pull the U.S. economy out of the worst financial crisis and recession since the 1930's.
Under Bernanke's leadership, the Fed created extraordinary programs after the financial crisis erupted in 2008 that are credited with helping save the U.S. banking system. The Fed lent money to banks after credit markets froze, cut its key short-term interest rate to near zero and bought trillions in bonds to lower long-term borrowing rates. Yellen, 67, emerged as the leading candidate after Lawrence Summers, a former Treasury secretary whom Obama was thought to favor, withdrew from consideration last month in the face of rising opposition. A close ally of the chairman, she has been a key architect of the Fed's efforts under Bernanke to keep interest rates near record lows to support the economy, and she would likely continue steering Fed policy in the same direction as Bernanke. The White House announcement comes in the midst of a confrontation between Obama and congressional Republicans, particularly those in the House, over the partial government shutdown and the looming breach of the nation's $16.7 trillion borrowing limit. Obama has been harshly critical of Republicans for demanding either changes in health care or spending policies in exchange for paying for government operations and raising the debt ceiling.Check Out Our Best Services for Investors
Action Alerts PLUS
Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.
Product Features:
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
Quant Ratings
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
Product Features:
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
Stocks Under $10
David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.
Product Features:
- Model portfolio
- Stocks trading below $10
- Intraday trade alerts
Check Out Our Best Services for Investors
Dividend Stock Advisor
David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
Product Features:
- Diversified model portfolio of dividend stocks
- Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks
Every recommendation goes through 3 layers of intense scrutinyquantitative, fundamental and technical analysisto maximize profit potential and minimize risk.
Product Features:
- Model Portfolio
- Intra Day Trade alerts
- Access to Quant Ratings
Options Profits
Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
Product Features:
- Actionable options commentary and news
- Real-time trading community


text:
Great food, very new, modern and clean rooms, convenient box for bicycles. What a pity for a very cold welcoming and not helpful owners. As said everything was OK with the room, yet the price is not extremely convenient.
Germany >
Bavaria >
Franconia >
Middle Franconia >
Free High Speed Internet ( WiFi )
Free Parking
Children Activities ( Kid / Family Friendly )
Pets Allowed ( Dog / Pet Friendly )
Room Service
Wheelchair access
Ranked #1 of 1 B&Bs / Inns in Treuchtlingen
Price Range (Based on Average Rates):
Number of rooms: 11
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Priceline and Odigeo so you can book your Gasthof Zum Goldenen Lamm reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


text:
A 100-Gb/s noncoherent silicon receiver for PDM-DBPSK/DQPSK signals |
Optics Express, Vol. 22, Issue 2, pp. 2150-2158 (2014)
Enhanced HTML Acrobat PDF (1331 KB)
An integrated noncoherent silicon receiver for demodulation of 100-Gb/s polarization-division multiplexed differential quadrature phase-shift keying and polarization-division multiplexed differential binary phase-shift keying signals is demonstrated. The receiver consists of a 2D surface grating coupler, four Mach-Zehnder delay interferometers and four germanium balanced photodetectors.
© 2014 Optical Society of America
OCIS Codes
(060.2330) Fiber optics and optical communications : Fiber optics communications
(060.5060) Fiber optics and optical communications : Phase modulation
(130.0130) Integrated optics : Integrated optics
(130.3120) Integrated optics : Integrated optics devices
ToC Category:
Optical Communications
Original Manuscript: November 28, 2013
Revised Manuscript: January 12, 2014
Manuscript Accepted: January 13, 2014
Published: January 24, 2014
Jonathan Klamkin, Fabrizio Gambini, Stefano Faralli, Antonio Malacarne, Gianluca Meloni, Gianluca Berrettini, Giampiero Contestabile, and Luca Potì, "A 100-Gb/s noncoherent silicon receiver for PDM-DBPSK/DQPSK signals," Opt. Express 22, 2150-2158 (2014)
Sort: Year | Journal | Reset
- M. A. Taubenblatt, "Optical interconnects for high-performance computing," J. Lightwave Technol. 30(4), 448–457 (2012). [CrossRef]
- C. Gunn, "CMOS photonics for high-speed interconnects," IEEE Micro 26(2), 58–66 (2006). [CrossRef]
- C. R. Doerr, N. K. Fontaine, L. L. Buhl, "PDM-DQPSK silicon receiver with integrated monitor and minimum number of controls," IEEE Photon. Technol. Lett. 24(8), 697–699 (2012). [CrossRef]
- P. Dong, L. Chen, C. Xie, L. L. Buhl, Y.-K. Chen, "50-Gb/s silicon quadrature phase-shift keying modulator," Opt. Express 20(19), 21181–21186 (2012). [CrossRef] [PubMed]
- P. Dumon, W. Boegarts, V. Wiaux, J. Wouters, S. Beckx, J. Van Campenhout, D. Taillaert, B. Luyassert, P. Bientsman, D. Van Thourhourt, R. Baets, "Low-loss SOI photonic wires and ring resonators fabricated with deep UV lithography," IEEE Photon. Technol. Lett. 16(5), 1328–1330 (2004). [CrossRef]
- A. Novack, Y. Liu, R. Ding, M. Gould, T. Baehr-Jones, Q. Li, Y. Yang, Y. Ma, Y. Zhang, K. Padmaraju, K. Bergman, A. E.-J. Lim, G.-Q. Lo, M. Hochberg, "A 30 GHz silicon photonics platform," Proc. SPIE 8781, 878107 (2013). [CrossRef]
- P. J. Winzer, R.-J. Essiambre, "Advanced modulation formats for high-capacity optical transport networks," J. Lightwave Technol. 24(12), 4711–4728 (2006). [CrossRef]
- C. R. Doerr, P. J. Winzer, Y.-K. Chen, S. Chandrasekhar, M. S. Rasras, L. Chen, T.-Y. Liow, K.-W. Ang, G.-Q. Lo, "Monolithic polarization and phase diversity coherent receiver in silicon," J. Lightwave Technol. 28(4), 520–525 (2010). [CrossRef]
- Y. Painchaud, M. Pelletier, M. Poulin, F. Pelletier, C. Latrasse, G. Robidoux, S. Savard, J.-F. Gagné, V. Trudel, M.-J. Picard, P. Poulin, P. Sirois, F. D'Amours, D. Asselin, S. Paquet, C. Paquet, M. Cur, M. Guy, M. Morsy-Osman, Q. Zhuge, X. Xu, M. Chagnon, and D. V. Plant, "Ultra-compact coherent receiver based on hybrid integration on silicon," in Proc. OFC, paper OM2J.2, Anaheim, CA (2013). [CrossRef]
- B. Mikkelsen, "Challenges and key technologies for coherent metro 100G transceivers," Lightwave Magazine, 14–18 (NOV/DEC 2012).
- A. H. Gnauck, P. J. Winzer, "Optical phase-shift-keyed transmission," J. Lightwave Technol. 23(1), 115–130 (2005). [CrossRef]
- R. A. Griffin and A. C. Carter, "Optical differential quadrature phase-shift key (oDQPSK) for high capacity optical transmission," in Proc. OFC, paper WX6, Anaheim, CA (2002). [CrossRef]
- C. R. Doerr, L. Zhang, L. L. Buhl, J. H. Sinsky, A. H. Gnauck, P. J. Winzer, A. L. Adamiecki, and N. J. Sauer, "High-speed InP DQPSK receiver," in Proc. OFC, paper PDP23, San Diego, CA (2008).
- L. Zimmermann, K. Voigt, G. Winzer, and K. Petermann, "Towards silicon on insulator dqpsk demodulators," in Proc. OFC, paper OThB3, San Diego, CA (2010). [CrossRef]
- S. Faralli, K. N. Nguyen, J. D. Peters, D. T. Spencer, D. J. Blumenthal, J. E. Bowers, "Integrated hybrid Si/InGaAs 50 Gb/s DQPSK receiver," Opt. Express 20(18), 19726–19734 (2012). [CrossRef] [PubMed]
- K. Xu, Z. Cheng, C. Y. Wong, H. K. Tsang, "Tunable integrated variable bit-rate DPSK silicon receiver," Opt. Lett. 37(22), 4738–4740 (2012). [CrossRef] [PubMed]
- F. Gambini, S. Faralli, A. Malacarne, G. Meloni, G. Berrettini, G. Contestabile, L. Potì, and J. Klamkin, "A Silicon receiver for 100 Gb/s PDM-DQPSK signals," in Proc. Photonics in Switching Conference, paper PD2–1, Kyoto, Japan (2013).
- D. Taillaert, H. Chong, P. I. Borel, L. H. Frandsen, R. M. De La Rue, R. Baets, "A compact two-dimensional grating coupler used as a polarization splitter," IEEE Photon. Technol. Lett. 15(9), 1249–1251 (2003). [CrossRef]
- S. Spector, M. W. Geis, D. Lennon, R. C. Williamson, and T. M. Lyszczarz, "Hybrid multi-mode/single-mode waveguides for low loss," in Proc. Integrated Photonics Research Conference, paper IThE5, San Francisco, CA (2004).
- H. Kim, P. J. Winzer, "Robustness to laser frequency offset in direct-detection DPSK and DQPSK systems," J. Lightwave Technol. 21(9), 1887–1891 (2003). [CrossRef]
Cited By |
Alert me when this paper is cited |
OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


text:
Schack — Malkuch
Alex Schack and Jim Malkuch, both of Minneapolis, are engaged to be married Aug. 31 at Carlos Creek Winery in Alexandria.
Alex is the daughter of Jim and Michelle Schack of Champlin and Julie and Mike Vinar of Circle Pine.
She is a 2006 graduate of Champlin Park High School and a 2010 graduate of Bethel University with a bachelor's degree in nursing.
Get the full story
Subscribe or Log In
Are you a newspaper subscriber but you don't have a Digital Access account yet? Activate your account.
You will need your subscription account number and phone number. Not sure if you have an account? Email us or call 320-214-4364 and we can help you.


text:
Photo Gallery |
New To Cycling? |
2007 Archive (and earlier) |
Previous | Back to the story | Next |
Univega Pro Team - Nicole Cooke, Priska Doppmann, Sarah Duester, Joe Kiensonowski, Christiane Soeder, Emma Rickards
Photos taken by WomensCycling.net photographers can be purchased as prints. Its easy - just click below for an order form >> Order Forms click here to open order form (to print from the web) click here to download PDF click here to download Word.doc Check out other race photos on our other site >> www.VeloPhoto.net To Editors and Webmasters All
images remain the property of the photographer, by whom all rights are
retained, 2004, 2005© . High-resolution images are available upon request for print purposes |


text:
Econo International Travel Inc
0  Reviews
Minneapolis, MN 55405
- Book Travel Faster: KAYAK
- We Search 100s of Sites at Once. Compare Flights and Hotels to Save!
- Serving your area
Hotels in Las Vegas | Hotels in New York |
Hotels in Orlando | Hotels in Los Angeles |
Phone Numbers
- main:
(612) 374-3789
- Featured Businesses
Ultimate All Inclusive Resort Travel Agency
Your All Inclusive Resort and Upscale Luxury Resort Experts
(888) 431-1631
1.3 Miles
720 W Lake St, Minneapolis, MN 55408
"Easy to work with - looking out for the model's best interests. Great to work with!">
2.8 Miles
4517 W Lake St, Minneapolis, MN 55416
"Welcome To The #1 Minneapolis Strippers Hottest Adult Entertainment In The 5 State Area With...">
1.3 Miles
950 Hawthorne Ave, Minneapolis, MN 55403
"Rude bus drivers! They must have been drill sargents! My husband and I booked through Greyho...">


text:
D.R. Horton, Inc., America's Builder, Reports Fiscal 2013 First Quarter Earnings
D.R. Horton, Inc. (NYSE:DHI), America's Builder, today reported that net income for its first fiscal quarter ended December 31, 2012 increased 139% to $66.3 million, or $0.20 per diluted share. Net income for the same quarter of fiscal 2012 was $27.7 million, or $0.09 per diluted share. Homebuilding revenue for the first quarter of fiscal 2013 increased 39% to $1.2 billion from $0.9 billion in the same quarter of 2012. Homes closed in the quarter increased 26% to 5,182, compared to 4,118 homes in the year-ago quarter.
Net sales orders for the first quarter ended December 31, 2012 increased 39% to 5,259 homes from 3,794 homes in the year-ago quarter and the value of net sales orders increased 60% to $1.3 billion from $0.8 billion. The Company's cancellation rate (cancelled sales orders divided by gross sales orders) for the first quarter of fiscal 2013 was 22%. The Company's sales order backlog of homes under contract at December 31, 2012 increased 62% to 7,317 homes from 4,530 homes at December 31, 2011. The value of the backlog increased 80% to $1.8 billion at December 31, 2012 from $1.0 billion a year ago.
The Company ended the quarter with $643.1 million of homebuilding unrestricted cash and marketable securities and net homebuilding debt to total capital of 33.0%. Net homebuilding debt to total capital consists of homebuilding notes payable net of cash and marketable securities divided by total equity plus homebuilding notes payable net of cash and marketable securities.
Donald R. Horton, Chairman of the Board, said, "This quarter was our most profitable first quarter since 2007, with $107.9 million of pre-tax income, a 270% increase from the year-ago quarter. We experienced substantial increases in the number of homes sold, closed and in backlog compared to the year-ago quarter. At the same time, our average sales price has increased due to pricing power, geographic mix and larger average home size. As a result, we achieved dollar value increases in homes sold of 60%, homes closed of 38% and backlog of 80%.
Check Out Our Best Services for Investors
Action Alerts PLUS
Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.
Product Features:
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
Quant Ratings
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
Product Features:
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
Stocks Under $10
David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.
Product Features:
- Model portfolio
- Stocks trading below $10
- Intraday trade alerts
Check Out Our Best Services for Investors
Dividend Stock Advisor
David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
Product Features:
- Diversified model portfolio of dividend stocks
- Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks
Every recommendation goes through 3 layers of intense scrutinyquantitative, fundamental and technical analysisto maximize profit potential and minimize risk.
Product Features:
- Model Portfolio
- Intra Day Trade alerts
- Access to Quant Ratings
Options Profits
Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
Product Features:
- Actionable options commentary and news
- Real-time trading community


text:
Born in Zagreb capital city of Croatia. Love playing games and mods. Hope one day I'll learn to mod them myself. ^_^
No addons were found matching the criteria specified. We suggest you try the addon list with no filter applied, to browse all available addons. Join now to share addons with the community.


text:
Kris Gross, a student enrolled in the College's Psy.D. (Doctor of Psychology) program was featured as "Volunteer of the Week" in the Main Line Times.
For the full story, click here.
You are cordially invited to the School of Graduate Studies' Spring Information Session on Saturday, March 14 at 11:00. Faculty from each department will give program presentations, and admissions staff will explain the admissions process. Come find out about CHC's graduate degrees, enjoy refreshments and receive an application fee waiver (master's level) or a discount coupon (Psy.D.). Register today or contact Andrew at firstname.lastname@example.com for more information.


text:
Horror Short Stories
Random Horror Short Stories
Most Favorited Horror Short Stories
Top Horror Short Stories
Most Viewed Horror Short Stories
Latest Horror Short Stories
Where Is She? Whats Going On?
A young girls mum dies and her dad looks after her until he hangs him self and then the dad takes over the girls body.
zoec (14) 3 months ago
young american high school kids in school by woods and decide to climb over fence but never came back out and weren't seen again
drizzydarcyxxx (18) 4 months ago
Marrow (Chapter Three)
The girl asks a favor of him and against his better judgment Mark decides to go along with her.
killik15 (26) 5 months ago
Nightmare Eater Ch3
What are you willing to do to make your own dreams come true? Well, two security guards working at a government building is about to find out through a nightmare of hell.
resie (24) 6 months ago
Nightmare Eater Ch2
What are you willing to do to make your own dreams come true? Well, two security guards working at a government building is about to find out through a nightmare of hell.
resie (24) 6 months ago
Nightmare Eater Ch1
What are you willing to do to make your own dreams come true? Well, two security guards working at a government building is about to find out through a nightmare of hell.
resie (24) 6 months ago
The Devil May Cry: The Lost Sun
A fanfiction based on the devil may cry world as a character is taken down a path unknown and discovers something he wished he had not. A world broken and used like a soul scared and abused leaves him chasing his past, looking for his siblings whom ever t
Tauragon (20) 7 months ago
I am a Living Hell
Self-harm, suicide, depression, Hell. Emo story. Don't read if you hate depressing/violent/creepily satisfying things.
JustNicoleValiukas (17) 8 months ago
JUST HEARD A TAP AT MY WINDOW. Almost 2 am in Australia. Aaand its my cousin. Hmm (*whips out rifle*) somebody's gonna DIEEEE! (May contain FOUL language)
JustNicoleValiukas (17) 8 months ago
Black Souls
On a downward spiral again, have to get this shit out before I go crazy
JustNicoleValiukas (17) 8 months ago
The Stranger
Thought of this when I saw a crazy junkie guy on the street who started chasing me and my friends the other night.
JustNicoleValiukas (17) 9 months ago
The Field
This creepy ass shiz actually happened. It doesn't sound that scary, but if you were there you would have freaked.
JustNicoleValiukas (17) 10 months ago
Creepy, sort of post apocalyptic, somebody trying to find another living person.
JustNicoleValiukas (17) 10 months ago
The Facility Part Two
Zombie Apocalypse, virus style, continued. Noticed other guy calling sick people "the infected" (DANG) Sorry dude. I'll change it to "the diseased" or something.
JustNicoleValiukas (17) 10 months ago
Helios: Episode 1#
The War was hard. The Infected have come. Can Harrison save his son Ash before all hell breaks loose?
Gage6g (32) 10 months ago
The Zombie Apocolypse
21connollyap (39) 10 months ago
The prisoner
A man gets caught for robbery and is sentenced to 5 life sentences and by death life eternity until his debt is paid.
Jtodx90 (24) 10 months ago
Zombie Bedlam
Sergeant Blake's squad has been wiped out in a zombie ambush. Alone and outnumber, he must make his way back to the safety of his bunker.
robertmoons (58) 11 months ago
The Wolf Face
A woman encounters what she thinks might be a werewolf.
SharonKrager (66) 11 months ago
Quivering Candles
kind of another odd one by yours truly. please also rate and comment-thanks :)
MegPeg (15) 1 year ago
When Lambs Became Lions
not so scary and is really a poem about revenge/surviving (I left it for you to guess the reason for his actions)
MegPeg (15) 1 year ago
Cloud Ten Part Two (Scene For Contest)
What will Carter and the group do now that the camp is being raided by bandits?! Find out here.
Daytoneboy327 (12) 1 year ago
Marrow(chapter two)
After Noticing his observer, The strange girl haunts his dreams, After a week of sleepless nights Mark gets the chance to meet The mystery woman.
killik15 (26) 1 year ago
Marrow (Chapter one)
Mark is just a normal teenage guy, Normal life, Normal girlfriend normal school, Normal problems. At-least up to this point, He has and unusual issue, He's being stalked by a girl brandishing a set of fangs, an unstable mind and infatuation in her heart.
killik15 (26) 1 year ago
When My Guitar Gently Screams
A young, mediocre guitar player comes across an unusual, antique guitar that turns him into a world famous rock idol.
robertmoons (58) 1 year ago
The Mummy Curse - 1
Gabe is a american and he has come with his parents to the land of pyramids,Egypt . As he tours with his parents, he comes over strange things that give you all a goosebumps......................
khursheedabdallah6 (17) 1 year ago
my last days
a man is taken to "room 101" -it was my English course work- I have had numerous people tell me I should turn this into a story so, a story I shall turn it into. my first one xxx
becky15 (16) 1 year ago
The Hunger and the Cold
Something hungry this way comes. Three friends spending a weekend at an isolated log cabin, soon find themselves in a desperate battle for their very lives.
robertmoons (58) 1 year ago
Lester's Shift
There is a time before the sunrises that the moon clings to both the light and darkness for as long as possible. For an old gravedigger named Lester Paddock, it is within that time that he has come to know best for his work. Meanwhile, Jim Hutchings ends
treytac7 (23) 1 year ago
The Hidden Walls pg 4
alexander (19) 1 year ago
ruby slits
Multitmoney15 (18) 1 year ago
the wickens pride
Multitmoney15 (18) 1 year ago
The Hidden Walls pg 3
alexander (19) 1 year ago
The Hidden Walls pg 2
alexander (19) 1 year ago


text:
Author has written 2 stories for Percy Jackson and the Olympians. So My Name Is Dingy108,It once was my sister got mad at me for using it!!!!!!!!!!! really hate it when profiles are really long and you have to scroll down forever to see the stories so this will be short and to the point: :) Just so you know I love getting reveiws and PMs if you ever want to talk to someone about good stories or well anything I'm here.But im really sry if im making it long. EMAIL- email@example.com INSTAGRAM- Aishani108 TUMBLR- Aishani108 TWITTER- Aishani108 WATTPAD- Aishani108 PHONE #-LOL not gonna give you that!!!!! My Favroite Books Series -PJO-Percy Jackson and The Olympian -HOO-Heros Of Olympus -Krane Chronicals My Favroite Couples Percy/Annabeth=Percabeth Jason/Piper=Jasper Leo/Reyna=Leyna Rachel/Octavian Travis/Katie=Tratie Nico/Thalia=Thalico Carter/Zia=Zarter Anubis/Sadie=Sanubis Nico/Sadie=Sadico Thalia/Luke= Thaluke
A guy and girl are speeding down the road at 100 miles an hour-- Girl: Slow down, I'm scared! Guy: No, this is fun. Girl: No it's not. Please, just slow down.Guy: Then tell me that you love me. Girl: I love you, just slow down! Guy: Now give me a big hug. She gives him a hug. Guy: Can you take off my helmet and put it on yourself; it's bothering me. In the newspaper the next day, a motorcycle had crashed into the wall of a building because of brake failure. Two people were on it, and only one survived. The truth was that halfway down the road, the guy realized that his brakes weren't working, and didn't want the girl to know. Instead he had her hug him and tell him that she loved him one last time. Then he had her put on his helmet so that she would live even if he died. Copy this onto your profile if you would do the same thing for someone you loved. |


text:
Photograph by Sascha Schuermann/AFP/Getty Images
Published August 27, 2013
Domesticated pigs were present in northern Germany around 4600 B.C., some 500 years earlier than previously thought, new fossil and DNA evidence reveals.
The finding, detailed in this week's issue of the journal Nature Communications, is significant because the people living in that part of Europe at the time were Mesolithic hunter-gatherers who primarily lived off of wild game.
These people, known as the Ertebølle culture, kept domesticated dogs as hunting companions, but it would be several hundreds of years before they began raising animals and crops for food.
One hypothesis for how the Ertebølle came to acquire the pigs is that they traded for them with their farmer neighbors to the south.
"It would have been hard [for the hunter-gatherers] not to be fascinated by the strange-looking spotted pigs owned by farmers living nearby," study co-author Greger Larson, an archeologist at Durham University in the UK, said in a statement.
"It should come as no surprise that the hunter-gatherers acquired some eventually, but this study shows that they did very soon after the domestic pigs arrived in northern Europe."
What's New?
Using DNA analysis and tooth morphology comparison techniques, the scientists analyzed the bones and teeth of 63 pigs found at Ertebølle settlements in northern Germany.
The results showed that some of the pigs were domesticated animals that had both Near Eastern and European ancestry and which were similar to pigs bred by Neolithic farmers living in central Europe.
"This is really the first evidence that we have for the Ertebølle culture having domesticated animals at this early date," said study co-leader Ben Krause-Kyora, a biochemist and archeologist at Germany's Christian-Albrechts University.
It is not yet known whether the hunter-gatherers received the pigs via trade or exchange, or by hunting and capturing escaped animals. However, given the close proximity of the two groups and their occasional trading contact, the first scenario is more likely than the latter, the scientists say.
Why Is It Important?
Analyses of the teeth of the domesticated pig bones suggest the animals were smaller than those of boars living in northern Germany at the time.
This size reduction is characteristic of the first phase of domestication for many species, explained study co-leader Almut Nebel, a molecular biologist at Christian-Albrechts-University.
The remains also showed variations in the MC1R gene, which suggests the early farm pigs also had another classic trait of domesticated animals: coats that varied in color and that were spotted.
Overall, though, the ancient European porkers would have been leaner and smaller than modern varieties.
"Modern-day pigs are bred for high amounts of fat and meat," Krause-Kyora said. "Today's pig breeds have an extra pair of ribs ... and they also have a different skull shape."
The snouts of the ancient domesticated pigs would also have been longer and more boarlike than those of modern breeds.
What Does This Mean?
However the Ertebølle people acquired the pigs, there's no evidence that having the animals inspired them to try their hand at pig breeding themselves—at least not at this early date.
"It would be a couple hundred years before they really got into domestication," Nebel said. "It could have started with the pigs, but we don't know for sure."
What's Next?
Krause-Kyora said the team plans to take advantage of next-generation DNA sequencing methods to create a complete genome of the ancient domesticated pigs for comparison with those of modern pig breeds.
Follow Ker Than on Twitter.
Popular Stories
Smoke Is Feeding Stronger Tornadoes
A computer simulation of America's worst day of tornadoes in decades finds a link to land-clearing fires in Central America.
Why 'Mountaineer's Guide to Death' Matters
"People find it instructive and helpful, but also kind of fun—in a macabre kind of way," says the American Alpine Club's executive editor.
Rare Photo of Enormous Deep-Sea Fish
A photographer caught the 130-pound monster on camera in November off the southern California coast.
The Future of Food
Why Food Matters
How do we feed nine billion people by 2050, and how do we do so sustainably?
Download: Free iPad App
We've made our magazine's best stories about the future of food available in a free iPad app.


text:
S&P 500 index data: S&P 500 Copyright ©
All data supplied by Morningstar Real-Time Data. U.S. intraday real-time exchange quotes are sourced from BATS when available. End-of-day quotes for Nasdaq, NYSE, and Amex securities will appear 15 minutes after close. Graph times are Eastern Standard. © Copyright Morningstar, Inc .
Click above to view more mutual fund data and stats for ecyap - Eczacibasi Yapi Gerecleri Sanayi Ve Ticaret AS.


text:
Did you ruin your diet bye weighing yourself every day ? I did and I have finally binned the scale's batteries.
(5 Posts)Registering is free, easy, and means you can join in the discussion, get discounts, win prizes and lots more.
Register nowAlready registered with Mumsnet? Log in to leave your comment or alternatively, sign in with Facebook or Google.
Talk: Customise | Unanswered messages | Getting started | Acronyms | FAQs
Threads: Active | I'm on | I'm watching | I started | Last 15 minutes | Last hour | Last Day


text:
Why You May Have Noticed Beefed Up Security at Your Federal Office
- By Eric Katz
- January 14, 2015
- Leave a comment
Noticed more security guards in your federal office lately?
You're not paranoid.
Homeland Security Department Secretary Jeh Johnson announced this week the agency would ramp up security at federal buildings in response to the terror attacks in Paris last week. Johnson emphasized that there is no "specific, credible intelligence" of any threat on U.S. soil, and his decision is purely precautionary.
Public threats by terrorist organizations, however, have focused on "aircraft, military personnel, and government installations and civilian personnel," he said.
Johnson has asked the Federal Protective Service to enhance its presence at government buildings in Washington, D.C., and other "major cities and locations around the country." The secretary declined to elaborate on the exact locations, calling them law enforcement sensitive. He added sites of focus will shift and be reevaluated regularly.
The enhanced security builds on a similar DHS initiative launched in October, Johnson said, when a gunman in Canada shot and killed government personnel at a war memorial and the Parliament building.
"We urge Americans to continue to travel, attend public events, and freely associate with others," Johnson said. "However, given world events, this is a time for heightened vigilance by federal, state and local ...
What if the Problem Isn't the Rules, but the People?
- By Tom Shoop
- January 13, 2015
- Leave a comment
One school of thought holds that the rules and regulations governing the federal acquisition process are so byzantine that the government simply can't get access to the latest technology in a timely fashion.
But what if the problem isn't the rules, but the people who must work within them?
At an event in Washington on Tuesday, the National Academy of Public Administration and ICF International unveiled the results of their Federal Leaders Digital Insight Study. Among the subjects covered in the survey of senior federal leaders was the technology acquisition system.
The study found that while there certainly are problems in buying and implementing the latest technology in government, "many federal leaders believe that these problems are the result of execution of the procurement process rather than regulatory requirements." While nearly 40 percent of the more than 500 survey respondents had some influence in the procurement process, only one of them cited problems with the Federal Acquisition Regulation in written comments.
"The FAR isn't always the main hurdle," said Beth Cobert, deputy director for management at the Office of Management and Budget, at the event. "The processes really need to be tackled."
"One hundred page [requests for ...
Clapper and L 'il Bub
- By Katherine McIntire Peters
- January 12, 2015
- Leave a comment
Who knew the director of national intelligence had a soft spot for The Most Amazing Cat on the Planet? When our friends at the D Brief wrote this morning that "Jim Clapper talked about his big trip to North Korea last week with some amazing details," they weren't kidding. We highly recommend that anyone interested in the hermit kingdom, U.S. intelligence or cybersecurity read the text of Clapper's fascinating remarks at Fordham University Jan. 7, where he addressed the International Conference on Cybersecurity.
Clapper spoke at length about his extraordinary mission to Pyongyang last November to win the release of two American prisoners. He also discussed steps companies should take to enhance their cybersecurity. Our favorite takeaway, though, was this gem:
Two years ago, I didn't know what a "Tumblr" was. Two weeks ago, Tumblr featured our site, the IC's site, as one of a select few "Big in 2014" sites for their end of year review. We were right up there with "L'il Bub."
I'm here to tell you, sharing the stage with a famous cat—on the Internet—that's how you know you've arrived.
The Civil Servant Who Didn't Show Up to Work for 24 Years
- By Tom Shoop
- January 9, 2015
- Leave a comment
One of the big criticisms of the U.S. civil service system is that it's simply too hard to fire poor-performing employees. But compared to India, it's apparently a breeze.
Reuters reported this week on the case of A.K. Verma, an employee of India's Central Public Works Department, who recently was fired for failing to show up for work.
"He went on seeking extension of leave, which was not sanctioned, and defied directions to report to work," the Indian government said in a statement.
That was in December 1990.
You read that right: Verma skipped out on his job for 24 years. In 1992, he was found guilty of "willful absence from duty," but it took another 22 years before he was finally dismissed. India's civil service protections are considered some of the most stringent in the world.
Indian Prime Minister Narendra Modi, Reuters reported, has sought to crack down on "rampant absenteeism" by making government employees check in for work each day using a fingerprint scanner.
In Search of Heroes of the Public Service
- By Tom Shoop
- January 6, 2015
- Leave a comment
Do you think it's about time that outstanding public servants get some recognition for the work they do? Well, here's your chance to do something about it.
Nominations for this year's Service to America Medals, sponsored by the Partnership for Public Service, are closing soon--Jan. 16, to be exact.
All career civilian federal employees are eligible for the honor. Medals are awarded in eight categories:
- Career Achievement
- Call to Service
- Citizen Services
- Homeland Security and Law Enforcement
- Management Excellence
- National Security and International Affairs
- Science and Environment
- Federal Employee of the Year
Honorees are selected, the Partnership for Public Service says, based on the "impact of their work on meeting the needs of the nation, on-the-job innovation, and commitment to public service."
Thirty finalists for the awards will be recognized at a Capitol Hill event this spring. Winners will be honored in the fall at a gala dinner in Washington.


text:
New Swipe Fee Battle: More Consumer Pain?
NEW YORK ( LowCards.com) -- Another major dispute on interchange fees could take place, and this one may have new, painful consequences for consumers. This time, the battle centers around the swipe fee that retailers pay on credit card transactions.
According to CNBC, there is an antitrust suit between 5 million retailers and Visa (V - Get Report), MasterCard (MA - Get Report) and 13 large banks, including Citi (C - Get Report), Bank of America (BAC - Get Report), Chase (JPM - Get Report), Capital One (COF - Get Report), U.S. Bancorp (USB - Get Report) and Wells Fargo (WFC - Get Report). Retailers claim that banks and the payment systems have unfairly worked together to increase the amount of the interchange fee retailers pay on any purchase made with a credit card.
Shoppers may see even lower swipe fees at the checkout, but banks will surely look elsewhere to make up for billions in lost revenue. |
The amount each retailer pays as a swipe fee varies widely, but the industry average is approximately 2%. This antitrust suit could cut that figure by three-quarters, down to 0.5%. That would be one more devastating revenue blow to the banks as well as Visa and MasterCard, leading to billions of dollars in lost income.
When the Durbin amendment went into effect Oct. 1 it cut the interchange fee on debit card transactions from an average of 44 cents to no more than 21 cents (plus 0.05% of the transaction, with the possibility of an additional cent if banks comply with fraud prevention procedures). Banks tried to make up for this lost revenue by implementing a monthly debit card fee, which led to consumer outrage. Banks eventually gave it up. If the retailers win this antitrust suit, it could have have a significant impact on consumers:- Banks will lose billions of dollars after already suffering significant cutbacks in revenue. Whenever banks lose revenue in one area, they try to make up for it in another, and that always comes at the expense of the consumer. An increase in existing fees, the introduction of others and an increase in the credit card interest rates are changes that could be pushed.
- A significant decrease in credit card reward programs. The lucrative cash back and airline mile rewards will likely decline. Most banks eliminated debit card rewards when the Durbin amendment passed. The same could happen with credit card programs if retailers win this suit.
- A likely decrease in attractive balance transfer offers. Currently, credit card issuers are offering 0% interest rates for extended periods to lure customers from their competitors. The Citi Platinum Select card offers 0% for 21 months; the Discover (DFS - Get Report) More card offers 0% for 18 months; and the Slate from Chase card offers 0% for 12 months with no balance transfer fee. If retailers win this antitrust suit, look for credit card issuers to scale back these balance transfer offers.
- On the positive side, there could be a decrease in prices at store level. Retailers claimed the passage of the Durbin amendment could lead to a decrease in prices, since they would no longer have to pay the high swipe fees on debit card transactions. It is difficult to see if this actually took place. Retailers may face more pressure from consumer groups to cut prices if the interchange fee is also slashed on credit card purchases, though.
Check Out Our Best Services for Investors
Action Alerts PLUS
Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.
Product Features:
- $2.5+ million portfolio
- Large-cap and dividend focus
- Intraday trade alerts from Cramer
Quant Ratings
Access the tool that DOMINATES the Russell 2000 and the S&P 500.
Product Features:
- Buy, hold, or sell recommendations for over 4,300 stocks
- Unlimited research reports on your favorite stocks
- A custom stock screener
Stocks Under $10
David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.
Product Features:
- Model portfolio
- Stocks trading below $10
- Intraday trade alerts
Check Out Our Best Services for Investors
Dividend Stock Advisor
David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.
Product Features:
- Diversified model portfolio of dividend stocks
- Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks
Every recommendation goes through 3 layers of intense scrutinyquantitative, fundamental and technical analysisto maximize profit potential and minimize risk.
Product Features:
- Model Portfolio
- Intra Day Trade alerts
- Access to Quant Ratings
Options Profits
Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.
Product Features:
- Actionable options commentary and news
- Real-time trading community


text:
A faculty member at the University of Texas at Austin who works to improve the security and reliability of computer software systems has been awarded a Sloan Research Fellowship for 2015.
A faculty member at the University of Texas at Austin who works to improve the security and reliability of computer software systems has been awarded a Sloan Research Fellowship for 2015.
Scientists at one of the world's top computer science programs at UT Austin say artificial intelligence is enabling breakthroughs that will improve everyday life. This week many are involved in the Association for the Advancement of Artificial Intelligence (AAAI) 2015 conference, taking place this week in Austin.
Students from The University of Texas at Austin won $100,000 in seed funding for developing an idea for a smart phone app that would use artificial intelligence to help Texas residents get information about health care, food assistance and other social services in partnership with the United Way for Greater Austin's 2-1-1 Navigation Center.
A new computational technique developed at The University of Texas at Austin has enabled an international consortium to produce an avian tree of life that points to the origins of various bird species. A graduate student at the university is a leading author on papers describing the new technique and sharing the consortium's findings about bird evolution in the journal Science.
The University of Texas of Austin's computer science program is the 6th best in the world, according to the 2014 Academic Ranking of World Universities (ARWU) compiled by the Center for World-Class Universities at Shanghai Jiao Tong University.
College of Natural Sciences alumna, Hideko Kunii (Ph.D. '83) is a trailblazer in a culture that has a history of discouraging women from advancing in the workforce, most notably in the technology industries.
The University of Texas at Austin's Department of Computer Science is partnering with IBM to launch a new cognitive computing course titled "Automated Question Answering" that gives students unprecedented access to one of IBM's most prized innovations: Watson. The University of Texas at Austin is one of seven universities offering the new course this fall.
Two computer science sophomores are using the skills they gained in the Freshman Research Initiative to program flying robots and show them off to other students on campus. Robert Lynch and Matt Broussard, who were both involved in the Autonomous Intelligent Robotics FRI stream run by Dr. Peter Stone, had different ways of arriving in computer science but say research has enriched their undergraduate experience more than anything else.
The race is on to develop tools to help sift through the vast quantities of video that are being produced by wearable camera technology like Google Glass and Looxcie.
Topological insulators, a state of matter that was only discovered in the past decade, may enable dramatic advances in quantum computing and spintronics.
Students won the seventh annual Student Cluster Competition (SCC) this year at the Supercomputing '12 (SC12) conference in Salt Lake City. SC12 is the seminal international conference for high-performance computing.
BotPrize winners were scored as more human-like than half their human competitors.


text:
Getting the Most Mileage out of SEPA
Now that companies have done the hard work of complying with SEPA, they're eager to realize the benefits of standardized payments.
By Ben Moshinsky, Bloomberg | October 13, 2014
Recognition from 2014 Nobel Prize may help Jean Tirole influence policy; he sees regulation as crucial in preventing banks from taking too much risk.
By Michael J. Moore, Bloomberg | January 29, 2014
Recruiter says gap in trader pay has never been wider; investment banks deny that means the best traders are jumping ship.
By Christine Harper, Bloomberg | November 8, 2012
Signing on Clinton's chief of staff would signal Obama is ready to strike a deal to cut deficit.
By Cordell Eddings, Bloomberg | June 18, 2012
"A lot of people are waiting on the sidelines" as the Fed opens a policy meeting.
By Christian Vits and Gabi Thesing | June 2, 2011
Central bank head outlines his vision of how to better manage the currrency.
Web Seminars
Alexander Hamilton Awards - Operational Risk Management & Overall Excellence
Sponsored by Deloitte
March 11, 2015 at 11:00 am ET
Comprehensive Approach to Liquidity Risk Management
Sponsored by Kyriba
March 24, 2015 at 2:00 pm ET
How to Successfully Manage Liquidity as the Role of Treasury Expands
Sponsored by Bottomline Technologies
March 31, 2015 at 2:00 pm ET
View more web seminars
Resource Center
The tactics needed to survive sales tax in 2015 require preparing for the worst while...
Download the 4-Point Plan to Unlock Lease Origination Savings and learn how Fortune 500 companies...
Test your readiness for the upcoming FASB Lease Accounting Standard and download the Fall 2014...
Reval's all-in-one Software-as-a-Service (SaaS) solution for Treasury and Risk Management (TRM) provides the comprehensive and...
In this webinar, Dennis Carey, Solutions Consultant at Reval and Stephanie Villatoro, Senior Consultant at...
Incomplete and out-of-date fixed assets information can have a major financial and compliance impact. Find...
This Fall 2014 update to our lease accounting whitepaper includes new analysis around the estimated...
This white paper discusses how moving to modern tax automation software should be a major...
This guide details some of the stickiest issues and pitfalls facing fixed assets managers today....
This guide explains the differences between SaaS and ASP and clarifies how the power of...
View All »
T&R Express
T&R Express delivers coverage of developing stories and the latest studies on trends in finance & treasury – FREE. Sign up now:
You are signed up!
See more Treasury & Risk eNewsletters.
Advertisement. Closing in 15 seconds.


text:
Studio Nazar
This employer has taken extra steps to respond to reviews and provide job seekers with accurate company information, photos, and reviews. Interested for your company?Learn More.
Profile Unclaimed
Studio Nazar Technical Writer Hourly Pay in New York City, NY
2 employee salaries Back to all Studio Nazar New York City, NY Area Salaries
Studio Nazar is Hiring! Check out the latest Studio Nazar Technical Writer jobs
This salary is 9% above the local average. See all Technical Writer Salaries.
Base Pay
Total Compensation
Be the first community member to contribute total compensation for this company
Cash Bonus, Stock Bonus, Profit Sharing, Commission Sharing, Tips have not been reported for this role.
Be the first to get salary and job alerts
Explore Technical Writer Salaries
Looking beyond Studio Nazar?
Check out the latest Technical Writer Jobs or see Technical Writer Salaries at other companies.
See if they're hiring! Check out the latest Studio Nazar Jobs


text:
Problems? Is your data what you think it is? | |
PerlMonks |
Comment on |
( #3333=superdoc: print w/ replies, xml ) | Need Help?? |
The comma (,) constructs a list which is not what you want (as long as $new_row is just a string scalar). Interpolate your variables inside your quoted string, as suggested above, or use the dot (.) to join strings:
push @query_output, "First:" . $row->{'NAME_ONE'} . " Last: " . $row->{'NAME_TWO'} . " CITY: " . $row->{'CITY'} . "ZIP:" . $row->{'ZIP'};
Sorry if my advice was wrong.
In reply to Re: Format values into a hash question
by aitap


text:
Pinecone Napkin Ring
For your little cabin by the lake, your lodge in the woods or just wishful thinking in the city, these woodsy table accents look like just like they came from the forest floor. More
Discover decorating with wrought iron flair!$4.50 | MORE DETAIL |
Featured Offers
1st Birthday Gifts!
Celebrate with a personalized gift. Quality Gifts & Low Prices!
Custom Birthday Presents
Personalized birthday gifts for all ages. Order today & save!
Personalized Cookie Jar
Beautiful yet functional gift for a housewarming, shower or wedding.


text:
The market for oil and gas drilling rigs continues to deteriorate as oil companies cut back on investments, Seadrill Chief Financial Officer Rune Magnus Lundetrae
Merger positions combined company to play a dominant role in recapitalization of North Pacific fishing fleet and emerging Arctic oil gas operations. Kvichak
The humanitarian crisis in the Mediterranean Sea is spiralling out of control. EU Member States must act urgently to prevent the loss of thousands more lives,
VT Halter Marine launched ATB tug Kim M. Bouchard for Bouchard Transportation at Moss Point Marine facility on February 26, 2015. The 10,000hp twin screw ATB
The European Community Shipowners' Associations has released the results of a recent update of an Oxford Economics study on the economic value of the EU shipping