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D.H.G. Events and Meeting.
Help? Can you help to identified old photos?
Hello my name is Tom Cooper and I am creating this website to show my collection of old postcards of Dawley, and also with the help of friends hope to put on some information about local traders of yesteryear, and some stories of local characters.
I would like to say a big thank you to Malcolm Peel for his contribution to this website.
For more Dawley history go to Dawley Heritage website
This is a new site and if you have an old photo or recollection of old Dawley that you want to share and put on this website you can contact me at: firstname.lastname@example.com


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Special Event: MIP-TV
Headline News 9 Story Entertainment Announces Sales to Luk International
9 Story Entertainment announces sales of their animated children's series to Luk International for Spain and Portugal.
Headline News A New Season of 'Dennis and Gnasher' Moves into Production
Sticky Pictures and content producer Red Kite Animations announced today that the new series of Dennis and Gnasher has kicked off production.
Headline News DHX Media Adds New Broadcasters to 'Monster Math Squad'
DHX Media has made international sales of CGI animated preschool show Monster Math Squad as it prepares to showcase the series at MIPTV.
Headline News Coolabi's 'Poppy Cat' Finds Home on NBC KIDS
Poppy Cat has secured a further U.S. broadcast home within the brand new Sprout-programmed NBC KIDS.
Headline News m4e Picks up 2 New Films from March Entertainment
m4e AG has secured worldwide TV and home entertainment distribution rights (excl. North America and Australia) to March Entertainment's, new animation feature films.
Headline News m4e/Telescreen Announce New Partnership with Kidobi
m4e/Telescreen and Kidobi today announced a new digital distribution partnership that will bring several animated series from the extensive m4e/Telescreen catalogue to Kidobi's rapidly expanding online library. T
Headline News Henson to Develop 'Imaginocean' Animated Series
The Jim Henson Company is in development on a new animated children's series, IMAGINOCEAN, based on the critically acclaimed Off-Broadway musical, "John Tartaglia'sImaginOcean."
Headline News CAKE Takes on Chapman Entertainment Titles
Leading kids' entertainment specialist, CAKE has agreed a deal with Chapman Entertainment to distribute the company's entire catalogue of shows for the World excluding North America and the UK.
Headline News Nelvana Presents New Series, Fan Favorites at MIPTV
At MIPTV next week, Nelvana Enterprises will present a new preschool series in development, along with fresh episodes of many of its popular series.
Headline News Imira Signs New Broadcasters for 'Lucky Fred'
Imira Entertainment has signed up further broadcasters for its new series "Lucky Fred" as the show begins its global rollout.
Headline News Henson Signs Trio of Int'l License Deals
The Jim Henson Company heads to MIP-TV this year with multiple broadcast and home entertainment licensing agreements finalized for its trio of popular pre-school series.
Headline News CN Asia Pacific, Xilam to Co-Produce 'Oggy and the Cockroaches'
Cartoon Network Asia Pacific has entered into an exclusive co-production agreement with leading French animation studio, Xilam, to create season four of the hit animated comedy series: Oggy and the Cockroaches.
Headline News Jim Henson Company to Make 3D 'Sid The Science Kid ' Feature
Henson's first CGI animated movie in 3D marks new collaboration with co-production partners in China and will be available to international buyers at MIPTV 2012.
Headline News Millimages' 'Mouk' Goes Down Under
Leading European production and distribution company Millimages has secured a major broadcast deal for its new children's property "Mouk" with Australia's national broadcast, ABC TV.
Headline News CAKE Acquires 'Fleabag Monkeyface'
Leading kids' entertainment specialist CAKE has been appointed as the worldwide distributor for hit animation "Fleabag Monkeyface."
Headline News CAKE Appoints Helen Blayney VP International Sales
Leading kids' and family entertainment specialist CAKE has today announced the appointment of Helen Blayney as VP of International Sales, alongside two internal promotions within the sales team.
Headline News 9 Story Entertainment Announces Animation Slate
9 Story Entertainment announces its new and returning animation slate for MIPTV, featuring "Fugget About It," the company's first foray in producing primetime animation.
Headline News Henson Signs Int'l Broadcast Licensing Deals
The Jim Henson Company has announced a slate of international broadcast license agreements for the company's masterful, live-action fantasy feature films LABYRINTH and THE DARK CRYSTAL, and its ingenious science-fiction series, FARSCAPE. All three titles will be offered to international buyers at this year's MIP-TV.
Headline News The Osbournes Get Animated
Heavy metal legend Ozzy Osbourne and his family are returning to TV screens, voicing stop-motion animated versions of themselves in a new comedy sitcom, produced by Cuppa Coffee Studios.
Headline News Toon Goggles to Showcase Growing Library at MIPTV
Online kids channel Toon Goggles is coming to MIPTV 2012 to showcase the free COPPA-compliant online kids' channel and build on its growing library of kid friendly content.
Headline News Imira Entertainment Launches 'Lucky Fred' at MIPTV 2012
Imira Entertainment, Spain's leading production and distribution company specializing in youth programming, is set to launch the innovative interactive component of "Lucky Fred" alongside the new series at MIPTV 2012.
Headline News Nelvana Brings Comedy, Boys Action And More To MIPTV
Headline News Bolts And Blip Launches This Spring With New Broadcast Partners
Ahead of the upcoming MIPTV market, CJ Entertainment Inc. & ToonBox Entertainment have secured deals with international broadcasters to air RedRover Co. & ToonBox's animated comedy series BOLTS AND BLIP.
Headline News Skywriter Media Acquires Two New Kids Properties Heading Into MIPTV 2010
Independent producer/distributor, Skywriter Media & Entertainment Group has acquired two new children's properties, The Wumblers and Planet Echo, which will be introduced to international buyers at MIPTV 2010.

subset: commoncrawl


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Matthew Williamson Has the Hottest Fashionista Friends!
Sunday 8:37 PM, 20/02/2011
It's not Fashion Week if Olivia Palermo isn't there which is why we weren't surprised when she showed up Front Row at Matthew Williamson yesterday! Olivia looked great in a floor-length skirt,belt and felt hat and was greeted by the designer himself when she arrived! We also spotted supermodel Twiggy, Alexa Chung and Yasmin Le Bon on the red carpet!
Matthew Williamson
Fashion show
1 Comments


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Publications (20)52.4 Total impact
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ABSTRACT: SERBP1 (SERPINE1 mRNA binding protein 1) is an arginine methylated RNA binding protein and the modification affects protein interaction and intracellular localization. In the present study, we show that under normal growth condition without stress, SERBP1 interacts with some arginine methylated and stress granule-associated proteins such as hnRNPA1, FMRP, FXR1 in an RNA-dependent manner. We also show that after arsenite treatment, a fraction of full-length SERBP1 protein co-localizes with the typical stress granule marker TIA-1in the cytoplasmic SGs. Truncated SERBP1 with the N-terminal, middle RG or C-terminal deletions, or else any single domain segment containing the N-terminal, middle or C-terminal region, was recruited to SGs upon arsenite treatment but with reduced efficiency. Besides, upon arsenite treatment, diffuse cytoplasmic localization of SERBP1 was shifted to nuclear-dominant and concentrated nucleolar distribution. Similar distribution was observed when cells were treated with a methylation inhibitor adenosine periodate (AdOx) and was also detected in the N- or C-terminal domain deletions and all three single domain fragments even without stress induction. We further demonstrate that AdOx treatment delays the association/dissociation of SERBP1 with SGs. Hypomethylation retains SERBP1 in the nucleus/nucleolus regardless of arsenite treatment. Our study indicates that arginine methylation is correlated with the recruitment of SERBP to as well as its retention in stress granules and nucleoli. Our study is the first report of an RNA binding protein that can be shifted simultaneously to cytoplasmic SGs and nucleoli, two RNP-concentrated subcellular compartments, upon stress. This article is protected by copyright. All rights reserved.FEBS Journal 11/2013; · 3.99 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Increased expression of cellular membrane bound glucose-regulated protein 78 (GRP78) is considered to be one of the biomarkers for gastric cancers. Therefore, peptides or molecules with specific recognition to GRP78 can act as a guiding probe to direct conjugated imaging agents to localized cancers. Based on this rationale, GRP78-guided polymeric micelles were designed and manufactured for nuclear imaging detection of tumors. Thiolated GRP78 binding peptide (GRP78BP) was first labeled with maleimide-terminated poly(ethylene glycol)- poly(ɛ-caprolactone) and then mixed with diethylenetriaminepentaacetic acid (DTPA)-linked poly(ethylene glycol)-poly(ɛ-caprolactone) to form DTPA/GRP78BP-conjugated micelles. The coupling efficiency of micelles with radioisotope indium-111 ((111)In) was measured and analyzed by instant thin layer chromatography. The coupling efficiency of DTPA-conjugated micelles and DTPA/GRP78BP-conjugated micelles with (111)In was 85% and 93%, respectively. For characterization and trace imaging, the radioisotope (111)In-targeting tumors were detected and imaged in a xenograft murine model using nano single photon emission computed tomography/computed tomography. The results revealed that the radioactive intensity measured in the animals administered with GRP78BP-guided (111)In-labeled micelles was statistically higher than that in animals administered with (111)In-labeled micelles, demonstrating that GRP78BP more than doubled the accumulation of micelles to the tumor tissue (P < 0.05). The results indicate that the gastric cancer biomarker GRP78 is a probing target in the application of nuclear imaging for tumor diagnosis. This novel GRP78BP-guided micelle agent may be applied in clinical practice to complement the histological diagnosis.International Journal of Nanomedicine 04/2013; 8:1385-91. · 4.20 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: The survivals of gastric cancer (GC) patients are associated with early diagnosis and effective treatments. Therefore, it is urgent for the discovery of early GC biomarkers and tumor-targeting therapeutics. The aim of this study was to uncover putative tissue biomarkers of GC using 2D DIGE and then apply one of these specific markers in GC treatment. We found three putative biomarkers of GC with significant differences in expression level compared to adjacent normal tissue, including glucose-regulated protein 78 (GRP78) and glutathione s-transferase pi (GSTpi) with increased expression level, and alpha-1 antitrypsin (A1AT) with reduced expression level. The overexpressed GRP78 was used as a targeted protein for guiding the drugs to tumor cells, leading to more effective treatment for GC xenografts. Our results demonstrated that the designated GRP78-binding peptide based on the sequence, WIFPWIQL, was selectively prone to recognize and bind to GC MKN45 cells in vitro, and also improve the delivery efficiency of polymeric micelles-encapsulated drugs into tumor cells and displayed better therapeutic outcome in experimental animals. This strategy of GRP78-mediated drug targeting system may bring chemotherapeutic drugs with more precise targeting to tumor cells, leading to minimize side effects on patients after chemotherapy.Proteomics 07/2012; 12(15-16):2584-97. · 3.97 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Protein arginine methylation regulates a broad array of cellular processes. SERBP1 implicated in tumor progression through its putative involvement in the plaminogen activator protease cascade, is an RNA-binding protein containing an RG-rich domain and an RGG box domain that might be methylated by protein arginine N-methyltransferases (PRMTs). Asymmetric dimethylarginine (aDMA) was detected in SERBP1 and an indirect methyltransferase inhibitor adenosine dialdehyde (AdOx) significantly reduced the methylation signals. Arginines in the middle RG and C-terminal RGG region of SERBP1 are methylated based on the analyses of different deletion constructs. The predominant type I protein arginine methyltransferase PRMT1 co-immunoprecipitated with SERBP1 and the level of bound PRMT1 decreased upon the addition of AdOx. Recombinant PRMT1 methylated SERBP1 and knockdown of PRMT1 significantly reduced the aDMA level of SERBP1, indicating that SERBP1 is specifically methylated by PRMT1. Immunofluorescent analyses of endogenous SERBP1 showed predominant cytoplasmic localization of SERBP1. Treatment of AdOx or PRMT1 siRNA increased the nuclear localization of SERBP1. Analyses of different deletions indicated that the middle RG region is important for the nuclear localization while both N- and C- terminus are required for nuclear export. Low methylation of the C-terminal RGG region also favors nuclear localization. In conclusion, the RG-rich and RGG box of SERBP1 is asymmetrically dimethylated by PRMT1 and the modification affects protein interaction and intracellular localization of the protein. These findings provide the basis for dissecting the roles of SERBP1.Journal of Cellular Biochemistry 03/2012; 113(8):2721-8. · 3.37 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Human neutrophil peptides (HNPs) -1, -2 and -3 are significantly upregulated and were reported as biomarkers in gastric cancer (GC). However, the tissue location and function of HNPs 1-3 are still unclear in GC, and the spatial distribution of the triad needs to be disclosed. The aims of this study were to investigate the distribution and relationships among HNPs-1, -2 and -3, and assess whether infiltrated neutrophils accumulate in gastric tumor. In this study, paired samples (n=33) of the GC tissues and adjacent normal tissues from the same patients were obtained from surgery. Expression of HNPs 1-3 were detected by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The distributions of the HNPs 1-3 in GC tissues were investigated. After verification of HNPs-1 by immunohistochemistry, infiltrated neutrophils were also detected. Then, an in vitro assay was used to observe the binding capacity and measure the cytotoxic effect of HNPs-1 against AGS cells. Comparing to neighboring normal tissue, expressional level of HNPs 1-3 were significantly higher and their distributions overlapped in cancerous tissues of GC patients with high abundance in the lamina propria, whereas HNPs-1 was identified as the highest major peak. Moreover, HNPs-1, -2 and -3 correlated with each other. Besides, we also observed that increased infiltrated neutrophils accumulating in GC tissues, indicating that a strong positive correlation between HNPs 1-3 and infiltrated neutrophils. In addition, the further investigated demonstrated that the major peptide, HNPs-1, was statistically increased with the advance of tumor development from the early to advanced stage of GC (p< 0.05). Moreover, we also noticed that HNPs-1 with a great binding capacity to GC AGS cells in vitro can inhibit tumor cell growth. Our results suggest that neutrophil secreted peptides, HNPs 1-3, increased in the GC tissues and could be used as potential biomarkers detected using MALDI-TOF MS, implying that elevated neutrophils may be used as a tumor target for tumor treatment. The binding capacity of HNPs-1 with GC cells implies that tracking molecules conjugated with HNPs-1 could be applied as a specific probe for GC diagnoses.Disease markers 01/2012; 32(1):21-31. · 2.17 Impact Factor -
Article: Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein.
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ABSTRACT: Excessive consumption of alcohol contributes to alcoholic liver disease. Fatty liver is the early stage of alcohol-related liver disease. The aim of this study was to search for specific serological biomarkers of alcoholic fatty liver (AFL) compared to healthy controls, non-alcoholic fatty liver (NAFL) and liver fibrosis in a rodent model. Serum samples derived from animals with AFL, NAFL, or liver fibrosis were characterized and compared using two-dimensional differential gel electrophoresis. A matrix-assisted laser desorption ionization-time of flight tandem mass spectrometer in conjunction with mascot software was used for protein identification. Subsequently, Western blotting and flexible multi-analyte profiling were used to measure the expressions of the putative biomarkers present in the serum of animals and clinical patients. Eight differential putative biomarkers were identified, and the two most differentiated proteins, including upregulated C-reactive protein (CRP) and downregulated haptoglobin (Hp), were further investigated. Western blotting validated that CRP was dramatically higher in the serum of AFL compared to healthy controls and other animals with liver disease of NAFL or liver fibrosis (p < 0.05). Moreover, we found that CRP and Hp were both lower in liver fibrosis of TAA-induced rats and clinical hepatitis C virus-infected patients. The results suggest that increased levels of CRP are an early sign of AFL in rats. The abnormally elevated CRP induced by ethanol can be used as a biomarker to distinguish AFL from normal or otherwise diseased livers.Journal of Biomedical Science 08/2011; 18(1):52. · 2.74 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: The aim of this study is to compare efficacy and complications between fundus-down and conventional laparoscopic cholecystectomy (LC) in treating contracted gallbladders with gallstones. Between January 1999 and May 2008, 64 patients with contracted gallbladders and gallstones were included in the study. Main outcome measures included conversion rate, complication rate, bile duct injury rate, operation time, and postoperative stay. The average postoperative hospital stay for fundus-down technique was 5 ± 3 days, and 7 ± 3 days for conventional technique (P = 0.003). The conversion rate and complication rate were 0% (0/33) and 3.00% (1/33) for fundus-down technique, and 32.3% (10/31) and 22.6% (7/31) for conventional technique (P = 0.0009 and 0.02, respectively). In subgroup analysis, fundus-down LC seemed to lower the bile duct injury rate from 2/31 (6.5%) to 0/33 (0%) compared with 6/1,468 (0.4%) (P = 0.01 between 6.5% and 0.4% vs. P = 1.00 between 0% and 0.4%). It appears that fundus-down laparoscopic cholecystectomy is associated with lower conversion and complication rates and shorter postoperative hospital stay as compared with conventional laparoscopic cholecystectomy when used to treat patients with contracted gallbladders and gallstones.Surgical Endoscopy 01/2011; 25(1):284-91. · 3.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to compare the efficacy and safety of laparoscopic primary closure of the common bile duct (CBD) combined with percutaneous transhepatic cholangiographic drainage (PTCD) and laparoscopic choledocholithotomy with T-tube placement for the treatment of CBD stones. Between January 1991 and July 2002, 50 patients with choledocholithiasis and a CBD diameter larger than or equal to 1 cm underwent laparoscopic CBD explorations. The study group consisted of 10 patients undergoing laparoscopic primary closure of the CBD combined with PTCD. The control group consisted of 40 patients undergoing laparoscopic choledocholithotomy with T-tube placement. Parameters were compared statistically. The study group showed higher female/male ratio (6/4 vs. 8/32, P = 0.02), less stone numbers (1.90 +/- 0.88 vs. 3.40 +/- 1.65, P = 0.0078), shorter operation time (138 +/- 37 minutes vs. 191 +/- 75 minutes, P = 0.014), and shorter postoperative stays (7 +/- 3 days vs. 10 +/- 3 days, P = 0.0013). It seems that laparoscopic primary closure of the CBD combined with PTCD can shorten the operation time and postoperative stays as compared with laparoscopic choledocholithotomy with T-tube placement for the treatment of CBD stones.The American surgeon 05/2010; 76(5):517-21. · 0.92 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The goal of our study was to evaluate the influence of genetic polymorphisms of matrix metalloproteinases (MMP)-2, MMP-3 and MMP-7 on susceptibility to endometrial cancer. In the present study, we enrolled a total of 118 patients with endometrial cancer confirmed by histopathology, and 229 unrelated healthy individuals. Polymorphism for the MMP-2 (rs2285053), MMP-3 (rs3025058) and MMP-7 (rs11568818) genes was genotyped by polymerase chain reaction-restriction enzyme length polymorphism. The frequencies of MMP-7 -181 G/G and A/G genotypes were found to be significantly higher in cancer patients compared with healthy controls (p = 0.017). Stratification showed that individuals with MMP-7 -181 G allele were at increased risk for endometrial cancer when >50 years of age [odds ratios (OR) = 2.03; 95% confidence interval (CI) 1.21-3.39], endometrioid (OR = 1.80; 95% CI 1.11-2.92), low (stage I-II) (OR = 1.73; 95% CI 1.05-2.83) or high stage (stage III-IV) (OR = 2.69; 95% CI 1.16-6.24). Compared with the A/A genotype, the A/G + G/G genotype modified the risk of developing endometrial carcinoma and significance was detected in patients over 50 years old, and those with endometrioid type and high stage endometrial cancer. However, no significant difference in MMP-2 (-735 C/T) and MMP-3 (6A/5A) genotypes was observed between endometrial carcinoma cases and controls. This is the first report on the association of MMP-2, MMP-3 and MMP-7 gene polymorphisms in endometrial cancer. Our results suggest that individuals with the MMP-7 -181 G/G and A/G genotype may have an increased risk of developing endometrial cancer.Clinical Chemistry and Laboratory Medicine 03/2010; 48(3):337-44. · 2.96 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We analyzed autoantibodies against tumor-associated antigens (TAAs) in the serum of patients with endometrioma and healthy controls to determine whether autoantibodies can be accurate biomarkers for the diagnosis of ovarian endometrioma. Serum samples were obtained from 56 patients with endometriosis and 66 healthy women who served as normal controls. The titers of antibodies against a panel of eight TAAs were analyzed using enzyme-linked immunosorbent assay. We found that the serum IGFII mRNA-binding protein 1 (IMP1) autoantibody and cyclin B1 autoantibody could discriminate between healthy controls and endometriosis patients (AUC-ROC 0.777; 95% confidence interval [CI] 0.694-0.860, P<0.0005, and AUC-ROC 0.614; 95%confidence interval [CI] 0.513-0.714, P=0.031, respectively). Using 0.073 and 0.007 as the cutoff values for IMP1 and Cyclin B1 autoantibody, respectively, the sensitivity and specificity of IMP1 were 85.7 and 63.6%, respectively. When cylcin B1 was combined with IMP1, the specificity increased to 72.7% and the sensitivity slightly decreased to 83.9%. Our data suggest that IMP1 alone or combined with cyclin B1 seems to fulfill the requirements of sensitivity and specificity to become a useful clinical biomarker of endometrioma. However, further studies will be required to establish the predictive value and to support the clinical use of IMP1/cyclin B1 in the diagnosis and/or screening of endometriosis.Journal of Clinical Laboratory Analysis 01/2010; 24(5):357-62. · 1.14 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins known to possess a broad range of biological activities involved in tumorgenesis and mRNA expression of TIMP family members has been shown to be upregulated in numerous cancers and correlates with clinical outcomes. We investigated the association of TIMP-1 and TIMP-2 gene polymorphism with risk of endometrial cancer. In the present case-control study, we enrolled a total of 118 endometrial cancer patients confirmed by histopathology and 229 unrelated healthy individuals. Polymorphism for TIMP-1 (_372C>T) and TIMP-2 (_418G>C and _303C>T) genes was genotyped by PCR-RFLP. Frequency of TIMP-1_372C/C genotype and 372-C allele differed significantly between patients with endometrial cancer (38.1% and 56.4% respectively) and healthy individuals (22.7% and 44.1% respectively). Individuals with TIMP-1_372 C/C genotype were at higher risk of endometrial cancer (OR=2.37; 95%CI: 1.33-4.22). Stratification analysis showed that individuals with TIMP-1_372 C/C genotype were at increased risk for endometrioid (OR=2.46; 95% CI 1.34-4.53) and low stage (stages I-II) endometrial cancer (OR=3.24; 95% CI 1.22-4.13). However, no significant differences in TIMP-2_418G>C and TIMP-2_303C>T genotypes were observed between endometrial carcinoma cases and controls. Individuals with TIMP-1_372C/C genotype were at significantly higher risk of endometrial cancer.Clinica chimica acta; international journal of clinical chemistry 09/2009; 409(1-2):127-31. · 2.54 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to determine whether cytokine expression (interleukin [IL]-1beta, IL-6, IL-8, IL-10, and tumor necrosis factor [TNF]-alpha), C-reactive protein, and endotoxins on the first day of intensive care unit (ICU) admission are associated with hospital mortality in severe community-acquired pneumonia (CAP). This was a prospective study with bronchoalveolar lavage (BAL) and blood sampling. This study was carried out in a 44-bed medical ICU of a 1700-bed university hospital. Participants included 112 mechanically ventilated patients with severe CAP. Serum and BAL fluid IL-1beta, IL-6, IL-8, IL-10, TNF-alpha, C-reactive protein, and endotoxins on the first day of ICU admission were obtained. The concentrations of TNF-alpha in BALF and IL-6, IL-8, IL-10, and TNF-alpha in serum were higher in nonsurvivors than in survivor patients with CAP. Of these 112 patients with severe CAP (39%), 44 developed acute respiratory distress syndrome (ARDS); these patients seemed to have higher serum IL-6, IL-8, and IL-10 levels than did the non-ARDS group. Furthermore, in the ARDS population, we found that the endotoxin levels in the BAL fluid were higher in the survival than in the nonsurvival group and BAL fluid concentrations of IL-6, IL-8, and IL-1beta and sera levels of IL-6 and IL-10 were lower in the survival than in the nonsurvival group, and they were associated with a high negative predictive value. Serum and BAL fluid levels of the studied cytokines on admission may provide valuable prognostic information for patients with severe CAP.Journal of critical care 08/2009; 25(1):176.e7-13. · 2.13 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The human endometrium manifests different and distinct morphologies and physiologies during the different phases of the menstrual cycle. We aimed to determine which candidate genes demonstrate differential expression patterns in the endometrium during different phases of the menstrual cycle. Using differential display reverse transcription polymerase chain reaction to compare day 5 and day 18 human glandular endometrium obtained by laser capture microdissection, we identified a specific gene, NUDT9 (nucleoside diphosphate-linked moiety X motif 9). NUDT9 is known to function as a highly specific adenosine diphosphate ribose pyrophosphatase and has been mapped to chromosome 4q22.1. It gives rise to two alternatively spliced messenger RNAs, NUDT9alpha and NUDT9beta, encoding a member of the Nudix hydrolase family. In this study, we purified NUDT9 protein and produced an antibody, which we then used for immunohistochemical studies. Using this anti-NUDT9 antibody, we successfully demonstrated that NUDT9 protein was differentially expressed in endometrial glandular cells at different phases of the menstrual cycle. NUDT9 was also found to be expressed more prominently in the epithelial glandular component than in the stromal component of human endometrial carcinomas. We suggest that NUDT9 may be involved in the regulation of the menstrual cycle and may be related to the proliferation of glandular cells in the human endometrium.Taiwanese journal of obstetrics & gynecology 07/2009; 48(2):96-107. - [Show abstract] [Hide abstract]
ABSTRACT: Our previous studies found that insulin-like growth factor-I receptor (IGF1R) signaling blockade caused cardiac hypertrophy, and that apoptosis is required for upregulating the IGF-II and the IGF-II/ mannose 6-phosphate receptor (IGF2R) gene. However, the role of IGF-II in the regulation of cell apoptosis through IGF2R is little known. In this study, we hypothesized that IGF-II may induce cell apoptosis through IGF2R but is dependent on IGF1R activity. Western blots and TUNEL assay revealed that in the presence of IGF1R, exogenous IGF-II acts, like IGF-I, would increase phospho-Akt through IGF1R, but does not affect the caspase 3 activation and apoptotic induction in H9c2 cardiomyoblast cells. Conversely, AG1024, an inhibitor of IGF1R activity, causes cell apoptosis, and the treatment with IGF-II further enhances this process, implying that it occurs through IGF2R. Moreover, immunoprecipitation assay revealed that treatment with IGF-II could enhance the interaction of IGF2R with Galphai and Galphaq but reduce its binding with Galphas, resulting in the reduction of phospho-PKA and the activation of PLC-beta. Taken together, these data provide new insight into the dual role of IGF-II in the control of IGF1R dependent cell apoptosis and involved activation of IGF2R signaling. Improving IGF1R activity and suppressing IGF2R may be a good strategy to prevent the progression of heart disease with cardiomyocyte apoptosis.The Chinese journal of physiology 02/2009; 52(1):31-7. · 1.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The role played by IGF-II in signal transduction through the IGF-II/mannose-6-phosphate receptor (IGF2R) in heart tissue has been poorly understood. In our previous studies, we detected an increased expression of IGF-II and IGF2R in cardiomyocytes that had undergone pathological hypertrophy. We hypothesized that after binding with IGF-II, IGF2R may trigger intracellular signaling cascades involved in the progression of pathologically cardiac hypertrophy. In this study, we used immunohistochemical analysis of the human cardiovascular tissue array to detect expression of IGF2R. In our study of H9c2 cardiomyoblast cell cultures, we used the rhodamine phalloidin staining to measure the cell hypertrophy and western blot to measure the expression of cardiac hypertrophy markers atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in cells treated with IGF-II. We found that a significant association between IGF2R overexpression and myocardial infarction. The treatment of H9c2 cardiomyoblast cells with IGF-II not only induced cell hypertrophy but also increased the protein level of ANP and BNP. Using Leu27IGF-II, an analog of IGF-II which interacts selectively with the IGF2R, to specifically activate IGF2R signaling cascades, we found that binding of Leu27IGF-II to IGF2R led to an increase in the phosphorylation of protein Kinase C (PKC)-alpha and calcium/calmodulin-dependent protein kinase II (CaMKII) in a Galphaq-dependent manner. By the inhibition of PKC-alpha/CaMKII activity, we found that IGF-II and Leu27IGF-II-induced cell hypertrophy and upregulation of ANP and BNP were significantly suppressed. Taken together, this study provides a new insight into the effects of the IGF2R and its downstream signaling in cardiac hypertrophy. The suppression of IGF2R signaling pathways may be a good strategy to prevent the progression of pathological hypertrophy.Journal of Endocrinology 06/2008; 197(2):381-90. · 3.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The IGF-II/mannose 6-phosphate receptor (IGF2R) function in extracellular matrix (ECM) remodeling is known to occur as a result of transforming growth factor-beta (TGF-beta) activation and plasmin in the proteolytic cleavage level caused by the interaction between latent TGF-beta and urokinase plasminogen activator receptor (uPAR) respectively. In one of our previous studies, we found IGF-II and IGF2R dose-dependently correlated with the progression of pathological hypertrophy remodeling following complete abdominal aorta ligation. However, how this IGF2R signaling pathway responds specifically to IGF-II and regulates the myocardial ECM remodeling process is unclear. We found that IGF2R was aberrantly expressed in myocardial infarction scars. The matrix metalloproteinase-9 (MMP-9) zymographic activity was elevated in H9c2 cardiomyoblast cells treated with IGF-II, but not IGF-I. Treatment with Leu27IGF-II, an IGF2R specifically binding IGF-II analog, resulted in significant time-dependent increases in the MMP-9, tissue-type plasminogen activator (tPA), and urokinase plasminogen activator (uPA); and a reduction in the tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) protein expression. Furthermore, IGF2R expression inhibition by siRNA blocked the IGF-II-induced MMP-9 activity. We hypothesize that after IGF-II is bound with IGF2R, the resulting signal disrupts the balance in the MMP-9/TIMP-2 expression level and increases plasminogen activator (PAs) expression involved in the development of myocardial remodeling. If so, IGF2R signaling inhibition may have potential use in the development of therapies preventing heart fibrosis progression.Journal of Molecular Endocrinology 06/2008; 41(2):65-74. · 3.62 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Human dihydrolipoamide dehydrogenase (hE3) is a common component of alpha-ketoacid dehydrogenase complexes. Mutations of this homodimeric protein cause E3 deficiency and are always fatal. To investigate its reaction mechanism, we first performed multiple sequence alignment with other 17 eukaryotic E3s. According to hE3 structure and the result of multiple sequence alignment, two amino acids, T148 and R281, were subjected to mutagenesis and four hE3 mutants, T148G, T148S, R281N, and R281K, were expressed and assayed. The specific activities of T148G, T148S, R281N, and R281K are 76.34%, 88.62%, 12.50%, and 11.93% to that of wild-type E3, respectively. The FAD content analysis indicated that the FAD content of these mutant E3s were about 71.0%, 92%, 96%, and 93% that of wild-type E3, respectively. The molecular weight analysis showed that these three mutant proteins form the dimer. Kinetic data demonstrated that the K(cat) of forward reaction of all mutants, except T148 mutants, were decreased dramatically. The results of kinetic study suggest that T148 is not important to E3 catalytic function and R281 play a role in the catalytic function of the E3.Journal of Biomedical Science 02/2008; 15(1):37-46. · 2.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: According to the multiple alignment of various dihydrolipoamide dehydrogenases (E3s) sequences, three human mutant E3s of the conserved residues in the center domain, N286D, N286Q, and D320N were created, over-expressed and purified. We characterized these mutants to investigate the reaction mechanism of human dihydrolipoamide dehydrogenases. The specific activities of N286D, N286Q, and D320N are 30.84%, 24.57% and 48.60% to that of the wild-type E3 respectively. The FAD content analysis indicated that these mutant E3s about 96.0%, 99.4% and 82.7% of FAD content compared to that of wild-type E3 respectively. The molecular weight analysis showed that these three mutant proteins form the dimer. Kinetic's data demonstrated that the K(cat) of both forward and reverse reactions of these mutant proteins were decreased. These results suggest that N286 and D320 play a role in the catalytic function of the E3.Journal of Biomedical Science 04/2007; 14(2):203-10. · 2.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Due to their similarity to type IV pilus (Tfp) subunits, the pseudopilins, XpsG, -H, -I, -J and -K, have been predicted to form a pilus-like structure in the type II secretion (T2S) pathway. While overexpression of GspG can result in the formation of bundle structures, the functions of other pseudopilin are not known yet. In this study, we investigate the mutual interaction among the pseudopilins and characterize the specialized minor pseudopilin, XpsJ. By using gel filtration and Ni-NTA affinity chromatography, a linearly ordered interactive relationship is revealed among the four pseudopilins, XpsG-XpsI-XpsH-XpsJ. Notably, unlike the mutant XpsJ194 staying in the inner membrane, wild type XpsJ stayed in the outer membrane and blocked the extension of overexpressed XpsG to outside of the cell. By analogy with the Type I pilus structures, we hypothesize that the XpsH and XpsI might act as an adaptor to connect XpsJ with the major pseudopilin XpsG, and XpsJ might act as a tip to restrict the out-growth of XpsG in the pilus-like structure of the T2S pathway.Journal of Biomedical Science 02/2005; 12(4):587-99. · 2.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: p73 is one of the p53 family members which are transcription factors involved in the regulation of cell proliferation, apoptosis, and differentiation. In this study, we cloned the p73 cDNA from zebrafish ovary RNA. The consensus open reading frame (1923bp) encodes a polypeptide of 640 amino acids which shares 70-95% identity to the p73 of other vertebrates. Expression of zebrafish p73 mRNA is restricted to tissues such as skin, fin, brain, ovary, and testis, in contrast to the ubiquitous expression of zebrafish p53 and p63. During embryonic development, p73 transcripts are detected from the zygote period to the early larva stage. Whole-mount in situ hybridization reveals that p73 expression is in the brain, including olfactory bulbs, telencephalon, and hypothalamus, as well as in the pharyngeal arches and the nose. Moreover, p73 protein is found in the ovary and testis sections by immunohistochemical staining.Biochemical and Biophysical Research Communications 08/2003; 307(2):395-400. · 2.28 Impact Factor
Publication Stats
125 | Citations | |
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Chung Shan Medical University
- Institute of Medicine
臺中市, Taiwan, Taiwan
Taipei Medical University
- School of Medicine
Taipei, Taipei, Taiwan


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THAT'S RIGHT TRUE BELIEVERS!!! Parts Unknown, the Comic Book Store, is now open SEVEN DAYS A WEEK!!! Our Sunday hours are from 2PM to 6PM, so after you save your soul wherever you choose to worship, come by the comic shop and save some hard-earned cash on the best selection if current titles, back issues, trades and comic supplies around!
Click here to read the APA "Talking Comics" article, "The Jones God" written by John Hitchcock, a funny book fan and friend. (CLICK ON THE THUMBNAIL TO THE LEFT TO READ THE ENTIRE FULL-SIZED ARTICLE)
Russ. Really I do not know what to say. But, I will try. Rusty "Rus" Neese passed last Friday night/ Saturday morning from a heart attack. Rus was 51 years old. Rusty worked here at Parts Unknown about five to six hours a week for 23 years. He loved the Tarheels, Vikings and the Celtics. And he loved Professional Wrestling. When I became his roommate back in the eighties he sat me down and was very serious and asked me these questions. What is your favorite NBA team? My answer, the Lakers. Rus shook his head and said, " No." "Now the deal breaker, who is your favorite ACC team? And I said, "That is an easy one, there is only one team in the ACC worth cheering for, The North Carolina Tarheels!" Russ smiled and said, "OK, we can get a long then." I am sure he would have thrown me out of his apartment at Stones Throw if I had said State of Duke. Any one who knew him loved him. And that is the best thing I can say about any one. When I will think about Rus I will smile but it will take a while. Thank you Rus for all your support and effort here at Parts Unknown. You will be terribly missed.
On June 12, 2010 the world lost another legendary hero from the comic art world when Al Williamson passed away.
An icon and an inspiration, click here to read the APA "Talking Comics" articlewritten by John Hitchcock, one of Williamson's biggest fans and good friends.
And guess who did the illustrations? Our very own John Hitchcock! That's right, John contributed almost twenty drawings for inclusion in the book, pen-and-ink line drawings that reflect the stories contained inside.
Feel free to stop by the store and pick up a book for your loved ones!


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An amendment in the current Farm Bill would keep government protection for popcorn crops. Popcorn is a tiny kernel in U.S. agriculture, but without the subsidy prices of your favorite movie snack could rise.
National Conference of Mayors discuss jobs, infrastructure
Jun 15, 2012
City leaders have gathered in Orlando to discuss the state of the economy from the ground level.
PODCAST: Heat vs. Thunder and the limits of duct tape
Jun 15, 2012
This weekend Greece will hold crucial elections that may determine its future in the eurozone, we lay out the possible Monday morning scenarios. A barbershop quartet and the countries of the eurozone have much more in common than you think. Nokia puts giveaways to the test with free smartphones for first-year students at Seton Hall University. With few regulatory teeth, the new Consumer Financial Protection Bureau continues to carve out a role as the place people go to air financial grievances.
Fed survey: Median net worth fell 40% during recession
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A scary new survey from the Federal Reserve shows the average U.S. family's wealth plunged during the recession.
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The World Bank's outgoing president, Robert Zoellick, says that four years after eurozone debt became a problem, the world is entering a new and more precarious phase of the crisis. Starboard Venture has a 5 percent stake in AOL and now it wants three seats on the board of directors. Ahead of what's billed as a major speech by Barack Obama in Cleveland, Democratic strategists want the president to change his message to acknowledge slow growth.
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The Supreme Court is about to hand down its decision on the health care reform bill. Gallup's Frank Newport reveals what Americans think.
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The chairman and CEO of JPMorgan, Jamie Dimon, will be grilled on a huge trading loss by the bank's unit in London. Americans spend an average of $1,100 a year on clothes, and a lot of that is spent on cheap and trendy "fast fashion." Elizabeth Cline joins us to talk about the high cost of discount clothing detailed in her new book, "Overdressed." Verizon Wireless announced it's scrapping unlimited data plans which could force a change in our web surfing. And the popular '80s primetime soap, "Dallas," is getting remade with the all-important ad demographic of 18 to 35-year-olds in mind.


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J.R. Watkins Natural Home Care Aloe & Green Tea All Purpose Cleaner
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Hi I thought of a nice position for the computer workout and perhaps we could all help with ideas for new positions.
This position is clearly a draw if you know how to hold it. And that is a nice thing to know when you are playing against a opponet.
This is also a nice endgame position to know, withe to move and he wins.
These are indeed vital positions to know and understand. Maybe they're already in there though.
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Request booking
-Our flat is located in Giza city, just 2 minutes walking to the 3 Great Pyramids and the Sphinx.
-From the flat windows you have a very clear and close panoramic view to the pyramids especially at night ….. Very romantic.
-The flat is about 200 meters square, with a very nice view to the 3 pyramids.
-It is located at the second floor.
-Consists of 2 bedrooms, living room, full furnished kitchen and bathroom.
-The flat is characterized by its modern paints,furniture and porcelain floors.
Main bedroom:
-Full furnished room with king-sized bed.
You have a nice view of the Pyramids from the room window.
-The room has 2 speakers in the ceiling as a part of the sound system. (You have a control to switch the sound off from the room).
Sub-main bedroom:
-Full furnished room with 2 beds.
-From the windows of this room you have a panoramic view to the 3 pyramids.
Living room:
-Has a corner couch L – shaped.
-It contains all means of entertainment: T.V, Satellite receiver, DVD player, Internet and Cassette with radio.
-The cassette is connected to the sound system so you can enjoy music and movies on the sound system in the entire flat.
-Full furnished kitchen with modern style and light spots
-All machines are available:
- Gas cooker with 5 burners and oven.
- Hot oven.
- Large refrigerator.
- Automatic washing machine.
- Kettle
- Microwave
- Toaster.
-Very high tech water filter (there will be no need to buy mineral water in our flat. very economic..:)
-Has a speaker as a part of the sound system so you can cook while hearing music.
-Has a built-in dinner table so you can also have your meal in the kitchen while hearing soft music.
- Super finished complete bathroom with a bath shower.
Only few minutes walking you will be standing in front of the 3 Pyramids of Giza and the Sphinx.
Moreover, In the area you can either hire a hourse or beach-puggy to discover the desert all around you through the available Safari programs the shops all around as offers.
Around the apartment you will find all amenities, including supermarket, pharmacy, bakery, butchers and fresh fruit and vegetable shops.
Many restaurants for eating international(KFC and Pizza Hut very nearby) and local food
All types of transport available at any time of the day to get you any where around Cairo.
All you need for charming vacation is available and we will work hard to help you to enjoy your staying in our flat.
All my family members are tourist guides and they ready to help you to visit all the important historical places in Egypt.
-Our flat is located in Giza city, just 2 minutes walking to the 3 Great Pyramids and the Sphinx.
-From the flat windows you have a very nice panoramic view to the pyramids.
Room details
2 bedrooms, sleeps 5
Bedroom 1: 1 Double bed
Bedroom 2: 1 Single bed
Room for 4 in the living area
Indoor facilities
DVD/Blu-ray player
TV Languages in Local
Iron / board
Pots / pans
Towels / linen
Washing machine
Outdoor facilities
Sports and activities
Sights and attractions
Prices and availability
Last updated 13.10.2012
- From £254.27 per week
- From £254.27 per week
- From £254.27 per week
Arrival date range | Arrival and departure days | Whole weeks only | Minimum stay (nights) |
1st February 2015 to 31st May 2015 | None set | No | 3 |
Discounts and extras
This property does not have any discounts or extras set
This is exact location
- Nearest bar: 8km
- KFC and Pizza Hut: 1km
- Pharmacy: 2km
- Supermarket: 2km
Sonja from Marine
Owner reply:
Thanks Mrs. Sonja for your kind words and It was the greatest pleasure to have such a nice people like you as our generous guests.And it is an honour if you visit us many other times... Our apartment and all my family will be always ready for you.At the end, me and my family are sending great greetings to you,your wonderful husband and your cute children.... wishing for you all the best.Thanks for staying in the Pyramid Flat.
I am a dentist live and work in Saudia Arabia. I am renting my apartment under the management of my brother in Egypt. My father and all my brothers are tourist guides and they are welcoming all our guests and arrange their vacation plans.
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During this season of Advent, I've applied to six Doctor of Philosophy (Ph.D.) programs in theology. I have three more applications to submit by the end of the middle of the first full week of the New Year. I'm filled with both excitement and dread. Of course, any person applying to doctoral programs may simultaneously experience these emotions. Questions concerning acceptance, funding, and selecting which offer constantly fill my mind. However, my dread does not come from fear of rejection, lack of funding, or attending the "wrong" program. My dread comes from the prospect of engaging extensive study of some of the most complex theological issues our time. Specifically, I'm talking about theological inquiry into the meaning of human sexualities, race, and, gender. And to refract these issues through the lens of Christology and soteriology seems quite foreboding despite the necessity of such theological engagement.
Certainly, I am not the first person (or the last one for that matter) to engage these subjects. Liberationist theologians, namely feminist, womanist, black (male), Latino/a-American, Native, Asian-American, and LGBTIQ theologians, among others have challenged traditional Christian theologies and practices concerning the status of people who are not white, Western, middle-class, cisgender, heterosexual men in the life of the Church and the world. Currently, liberationist theologians have moved beyond defending the legitimacy of their theological agendas in the theological academy and Church. Instead, they now protest the legitimacy of the authority of the predominantly male-shaped traditions of Scripture and Christian traditions (i.e., Roman Catholicism, Protestantism, and Eastern Orthodoxy). I guess my dread lies in the fact that I very much see myself as a traditionalist. I'm an evangelical Protestant, raised and shaped in the Afro-Baptist tradition. Yet I am a black gay man. How can I defend the faith or tradition which condemns my blackness and sexuality as sinful and evil? How can I accept the authority of the Scriptures as the Word of God given the abuses and misuses of the Holy Writ to defame, dehumanize, and spiritually harm many marginalized people? How can I defend any semblance of the substitutionary atonement of Jesus Christ when said theory is used to legitimate Western retributive justice principles which disproportionately affect African-American and Latino/a people living in the United States when enacted? And what of my eschatology and its relation to social justice? How can I balance my heavenly-mindedness with my concern of being of earthly-good?
As I write out these questions, I see that theodicy seeps through them. The problem of evil rightly challenges any triumphalist theologies, whether conservative or liberal. Classically understood, theodicy is the defense or justification of the all-beneficent God in the face of enduring evil. The systemic evils which pervades this world, specifically global poverty, militarism, colonialism, racism, sexism, homophobia, transphobia, ableism, and other ills haven't been adequately reckoned with in Christian theology. Personally, I cannot do what I intend to do in my doctoral studies without addressing systems of oppression which affect women, non-whites, and queer folk. My evangelical commitments do not blind me to the fact that evangelical Christianity, whether manifested in the Black Church or white Protestant churches, painfully contributes to the spiritual, social, and political marginalization of many people. Indeed, theodicy plays a role in my dread.
I remember having a conversation with my pastor and former professor regarding his read of philosopher William R. Jones' book, Is God a White Racist?. Pastor Turner said in response to Jones' scathing critique of the early black theologians' handling of theodicy in their theology, he replied, "Black Christians' response to theodicy is [the] black preaching [tradition]. But we must always live with the question of theodicy before us." Considering the times we live in, especially when African-American women and men are unjustly killed, when black trans women are murdered without justice, when LGBTIQ youth commit suicide because of perceived and actual rejection from their families and communities, I certainly do not want to contribute to the oppression of anyone as I embark on seeking my own theological account of race, gender, and human sexuality in all of their manifestations. My evangelical beliefs and my commitment to full human flourishing (still on the fence to what this really means!) seem to be at war with each other. Dread sucks.
Interestingly, it might be beneficial for me to actually meditate on these things in light of the season. Advent is a season of joy, judgment, and hope. The coming of the Son of God into the world is certainly a time of great joy for many, but it is nonetheless a time of reflection upon the judgment which will come to a world filled with sin and evil done to the "least of these." There is much in this world that needs change–revolutionary change! Truly, we who are able must seek the good of others and protest the injustices that plague this world–even those done in the name of the Lord! Nevertheless, Advent is a season of hope. Hope doesn't come in ostentatious, gaudy, consumerist displays of pomp and circumstance. Hope comes in humble form–in the form of a child born to a young girl and her betrothed husband, both members of an oppressed minority group living under Empire. Years later, hope will be tried, condemned, and executed under the authority of this same Empire. It's a strange way for God to come into the world in order to overcome it's sinful ways, yet through the eyes of faith, I believe God in Jesus Christ does just that! I may be dreadful of the task that I'm embarking on, but I am hopeful that the Lord Christ will lead me to do theological work that participates in God's work to bring God's kingdom into the world.
Come to think of it, dread might just be a reminder of my own contingency and my need for salvation. I am contingent. I am human. I have partial knowledge. I am also a sinner. Dread might be humility that needs to remember the saving grace of God. Dread just might be what I need around for the length of my prospective academic career to keep my feet to the ground and my knees bended. But I cannot let dread consume my life. If I do so, I take my sight off of the coming of God into the world and I abdicate my vocation to teach, preach, and practice the faith. The good news is that when I do find myself on the "wrong" side, God is just, forgiving, and merciful. Therein lies my hope. Thanks be to God!


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12 Morceaux, Op.48 (Glière, Reinhold)
Free public domain sheet music from IMSLP / Petrucci Music Library
It is unlikely that this work is public domain in the EU, or in any country where the copyright term is life-plus-70 years. However, it is in the public domain in Canada (where IMSLP is hosted) and other countries where the term is life-plus-50 years (like China, Japan, Korea and many others worldwide). As this work was first published before 1923 or failed to meet notice or renewal requirements to secure statutory copyright, it is very likely to be public domain in the USA as well. |
Sheet Music
Piano Duet Scores
Complete score
*#13981 - 2.90MB, 55 pp. - (2) - V/V/27 - 2827x⇩
Publisher Info.:
Moscow: P. Jurgenson, n.d.[1910]. Plates 33743-33754.
Public Domain - Non-PD EU [tag/del]
Misc. Notes:
This file is part of the Sibley Mirroring Project.
General Information
Work Title | 12 Morceaux pour piano à 4 mains |
Alternative Title |
Composer | Glière, Reinhold |
Opus/Catalogue Number | Op.48 |
Movements/Sections | 12
Year/Date of Composition | 1909 |
First Publication | 1910 |
Piece Style | Romantic |
Instrumentation | piano 4 hands |


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mono/poly ... just beginning...
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Senior Member
Join Date: Apr 2014
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Posts: 586
Ah... I was under the impression that both men had said they weren't willing to talk with you about the situation. I'm glad to hear I misinterpreted what you were saying.
I'll agree to disagree with you about happiness being a compromise. I don't believe anyone's happiness should ever be something they have to give up or put aside as long as they aren't hurting others to gain it, but I realize not everyone feels that way.
People don't *have to* do anything in a poly situation, but sorting out *your* rules, comfort zone, etc. goes a whole lot easier if you're able to talk about it with the other people involved. Communication isn't a rule so much as a component of making a relationship work, and that applies whether it's a mono or poly relationship, in my opinion.
Short answer: You aren't crazy. Poly is more common than some people realize. But whether your *particular* situation can work is something only you and the other people involved can determine.
Me: 44, cis-het female, poly
Hubby: my husband, 42, monogamous
S2: my "attachment", male, 44, undetermined
Best Friend: male, 38, platonic; the one who keeps me sane through all this!
My daughters: Alt (age 19) and Country (age 16)
S2's sons: Spikes (age 9) and Beads (age 6)
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Hayden Library's new mobile device charging station
Posted February 24th, 2014 by Grace MladyForgot your phone charging cable? Hayden Library now hosts a KwikBoost mobile device charging station which charges both cell phones and iPads. The device offers two Apple device cables and six phone charging cables.
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Winnipeg Free Press - PRINT EDITION
Give stepmothers chance to adapt to blended family
DEAR MISS LONELYHEARTS: Recently, you've published "cold stepmother" situations. Although I completely agree with you about the detrimental effects of extreme cases, I feel like you're missing an important element. Women in these situations have unresolved abandonment issues. Unless these women are suffering from mental illness, they find these situations very challenging and are upset with themselves for having the feelings they do. It's easy to say, "Don't get involved with a man that has kids, if it bothers you so much" but the men love these women, and the women love their men. In an unhealthy way they view the kids as competition, which mature people wouldn't do. I know because I am one of those challenged women, working hard to overcome this issue. My partner and I love each other immensely. I love his kids, too. It's just something is hurting inside me. I'm not extreme, but I'm not as warm as I am to my own kids, and that's wrong. I try to really control it, but it hurts sometimes. These men should encourage their partners to get help. For your consideration -- Struggling But Improving, Winnipeg
Dear Struggling: Sometimes stepmothers feel their husband loves his bio children more than he loves them. When they see those children together, especially if they no longer live under the same roof, the dads focus love and attention on those kids. Some stepmoms feel pushed to the side. They need to realize it's a different kind of love and love for them, which is not in competition. They also need to understand the man will love them more if they are kind and warm to his children. Conversely, he will love them less if they are cold to the kids. Another factor? Sometimes the stepchildren are chilly to the stepmother from Day 1 and some are coached by their bio-moms to be that way. Everybody needs to be in counselling in a blended family at least for a time, in my not-so-humble opinion after reading about so many hurtful non-blends.
Dear Miss Lonelyhearts: This is in response to the man who goes dog-walking past the house of the woman who's always walking around her living room naked at night with the curtains open. The only problem for the man is that he can be arrested as he is breaking the law, and the naked woman will be found innocent. Good luck until the cops arrive. -- MK, Winnipeg
Dear MK: If she is putting on a show for him to see, she's not going to call the police unless that's part of her modus operandi -- tease and then play shocked, and turn in the guy. Dangerous game for him! Although it's dumb to keep walking by that picture window, you can bet he probably will, but let's warn him not to wear this out. Once she gets annoyed with him and his dog, she might play the shocked role and dial 911 for added drama.
Dear Miss Lonelyhearts: How do I meet accomplished men five to 10 years older? I tried the whole online dating thing, but it's hard. I mean I had many people interested, but it becomes overwhelming. There comes a point when it's difficult to remember who knows what, going over and over again talking about myself. I had to stop after a couple of weeks. I met a few people though. My family had enough. It was like, "Oh, who is she dating now?" Frankly it bothered me too. I am not that kind of girl, juggling men. Isn't dating supposed to be fun? Why is it so complicated? Where do I start? -- Deep in Thought, Winnipeg
Dear Thought: I remember you. You're the young woman who wrote recently who likes men almost as old as her father. Frankly, it seems you're looking for ways to be negative about looking for someone appropriate. You actually admit you can find people like this online, but then complain it's too much work. Yes, it is work wading through hundreds of profiles. But so what, if you find a winner? The idea is not to do a juggling act but for you to do the looking -- reading tons of profiles and zeroing in on someone who is really interesting and attractive. If you meet quickly and start dating, you stop writing the rest.
Questions or comments? Write Miss Lonelyhearts c/o Winnipeg Free Press, 1355 Mountain Ave., Wpg, R2X 3B6 or email firstname.lastname@example.com
Republished from the Winnipeg Free Press print edition December 3, 2012 D3
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Throwing away the key just throws away justice
7:15 AM 0Prime Minister Stephen Harper is most definitely a man of his word. Even if keeping that word will have the ...
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(had-row-sore)Meaning of name: Bulky lizard
Hadrosaurs were the most advanced members of a group of dinosaurs called ornithopods. All ornithopods had a beak at the front of their jaws to strip plants with and teeth for chewing. Hadrosaurs took chewing to a new level, having evolved a 'battery' of teeth — as many as six rows, each containing 45 to 60 teeth that acted like huge files for grinding coarse plant material. These teeth were constantly replenished by new teeth growing from below. Ornithopods also had cheeks that enabled them to chew without losing much food.
Hadrosaur locomotion was unusual, in that they moved on all four legs when foraging and walking slowly, but ran on their long hind legs with their bodies held horizontally when speed was required.
More is known about hadrosaurs than just about any other prehistoric animal. As well as complete fossilised skeletons of recently hatched, juvenile and adult animals, scientists have found mummified bodies, skin impressions, stomach contents, coprolites, footprints, eggs and nesting sites and possibly some internal organs.
The fossil on display at Melbourne Museum is still embedded in the sandstone in which it was found. Palaeontologists use the skull to identify hadrosaur species. Unfortunately, we cannot be sure of the identity of the specimen, as it is missing its head. It is probably Edmontosaurus.
Hadrosaur fossil on display in the Dinosaur Walk exhibition. Photographer Rodney Start. Source: Museum Victoria
Hi, will this exhibition be coming to Sydney at any stage?
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2/18/2015 San Francisco, CA Save This JobPosition: Data Scientist Job Summary Our team is focused on building the next generation of prescriptive analytics for the PeopleMatter Platform. We need additional Data Scientists to assist in building a recommendation system that provides actionable insights to improve our
2/10/2015 Charleston, SC Save This JobJob Description The ideal candidate is an unabashed data geek. You enjoy searching the Internet for datasets that you can explore and mashup to tell interesting stories. You view the skills you have at sourcing, collecting, and cleaning data as a means to an end; you are
2/13/2015 Boston, MA Save This JobDo you love coming up with new ways to tell stories with huge amounts of data? At ShareThis we have billions of ever changing data points for you to play with daily. If you love to research and come up with new and useful ways that will invigorate an explosively fast growing
1/18/2015 Palo Alto, CA Save This JobJob Description The ideal candidate is an unabashed data geek. You enjoy searching the Internet for datasets that you can explore and mashup to tell interesting stories. You view the skills you have at sourcing, collecting, and cleaning data as a means to an end; you are equally
1/14/2015 Austin, TX Save This JobJob Description The ideal candidate is an unabashed data geek. You enjoy searching the Internet for datasets that you can explore and mashup to tell interesting stories. You view the skills you have at sourcing, collecting, and cleaning data as a means to an end; you are equally
1/14/2015 Morrisville, NC Save This JobDoes making a new discovery from analyzing large datasets sound like fun? Would you like to use your math and computing skills to help improve patient outcomes? Do you want to help create new ways to deliver actionable information for healthcare providers to use to improve the
1/19/2015 Cleveland, OH Save This JobData Science is about trying to answer a business question/problem by applying scientific and mathematical techniques to data that is acquired from multiple disparate sources and communicating the finding to the business. The big data scientist needs to be able to program,
1/12/2015 New York, NY Save This JobIntegral Ad Science is the industry's leading provider of detection, prevention, and prediction of fraudulent activity in online advertising. We are looking for a talented data scientist to dig into more than 10 billion log records every day and uncover the myriad ways in which
12/30/2014 Seattle, WA Save This JobJOB DESCRIPTION We're now looking for senior data scientists with skills in statistical techniques and machine learning. We are a funded tech startup that specializes in providing internet security for ad tech. Our application processes a large amount of data daily. Experience
3/2/2015 New York, NY Save This JobKnewton is an education startup funded by high-profile investors including Peter Thiel and Reid Hoffman. Located in the heart of Manhattan in the Union Square area, Knewton is building the world's most powerful adaptive learning engine, with the goal of making personalized and
1/3/2015 New York, NY Save This JobSome major projects the Exchange team is currently working on: continuing to scale our core exchange platform, honing the intelligence of our optimization, cutting feedback time for business intelligence, improving fraud protection, and aggressive automation. Currently, the
1/25/2015 New York, NY Save This JobViant is looking for a Consumer Data Analyst to join the Product and Data Science team. As a Consumer Data Analyst, you will work closely with a multi-talented team to support Vindico?s Data initiatives by helping to design, implement, and curate the next generation of our
2/12/2015 Irvine, CA Save This JobAbout Foursquare: Foursquare helps you and your friends make the most of where you are. We're a small but highly ambitious company with millions of users worldwide relying on Foursquare to keep up with friends, discover what's nearby, save money and unlock deals. We?re also
1/27/2015 New York, NY Save This JobSan Francisco, United States Note: Due to volume of applications we receive, we kindly ask that you only apply to a maximum of one Data Scientist role from among those posted. This does not preclude you from being considered for multiple roles. Thank you. Airbnb has become
2/26/2015 San Francisco, CA Save This Job