text:
"What are beta blockers and how do they work?
Beta blockers, also known as beta-adrenergic blocking agents, are a class of drugs that works by blocking the neurotransmitters norepinephrine and epinephrine from binding to receptors. "...
Coreg Side Effects Center
Medical Editor: Charles Patrick Davis, MD, PhD
Coreg (carvedilol) is a beta-adrenergic blocking agent used to treat heart failure, hypertension, and left ventricular dysfunction after a heart attack. Generic Coreg is available and is named carvedilol. Common side effects of Coreg may include diarrhea, nausea, vomiting, weakness, headache, cough, vision changes and paresthesias.
Coreg is available in strengths of 3.125, 6.25, 12.5, or 25 mg tablets. Coreg is usually taken with food; the recommended starting dose of Coreg (carvedilol) is 3.125 mg twice daily for 2 weeks for heart failure while for other problems, the starting dose is 6.25 mg twice a day. Coreg may have serious side effects that include hypotension, chest pain, irregular heartbeat, difficult breathing and swallowing, hives or rash, swelling, and fainting. Patients with hepatic impairment should not take Coreg. Care should be taken if the patient is taking other drugs, especially those that affect blood pressure and glucose levels as these may interact with Coreg and produce hypotension or low glucose blood levels. Severe exacerbation of angina, heart attack and ventricular arrhythmias has been reported in angina patients following the abrupt discontinuation of therapy with beta-blockers like Coreg. Effectiveness of COREG (carvedilol) in patients younger than 18 years of age has not been established. There are no adequate and well-controlled studies in pregnant or breastfeeding women; Coreg may be used during pregnancy or breastfeeding only if the potential benefit justifies the potential risk to the fetus or infant.
Our Coreg Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Coreg in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- feeling like you might pass out;
- slow or uneven heartbeats;
- chest pain, dry cough, wheezing, chest tightness, trouble breathing;
- feeling short of breath, even with mild exertion;
- swelling, rapid weight gain;
- numbness or cold feeling in your hands and feet;
- loss of bladder control;
- pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
- high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss); or
- severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious side effects may include:
- dizziness, drowsiness;
- nausea, vomiting, diarrhea;
- dry eyes;
- feeling weak or tired;
- joint pain;
- cough; or
- decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Coreg (Carvedilol) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Coreg Overview - Patient Information: Side Effects
Dizziness, lightheadedness, drowsiness, diarrhea, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. The risk of dizziness is highest within 1 hour after you take your dose. Taking this medication with food and starting treatment with a low dose and slowly increasing your dose as directed by your doctor help to reduce the risk of dizziness.
This drug may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: very slow heartbeat, severe dizziness, fainting, unusual weakness, change in the amount of urine, numbness/tingling of the hands/feet, blue fingers/toes, easy bruising/bleeding, mental/mood changes (such as confusion, depression), seizures.
Although this medication may be used to treat heart failure, some people may rarely develop new or worsening symptoms of heart failure, especially at the start of carvedilol treatment. Tell your doctor right away if you develop any of these serious side effects: swelling of the hands/ankles/feet, severe tiredness, shortness of breath, unexplained/sudden weight gain.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Coreg (Carvedilol)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Coreg FDA Prescribing Information: Side Effects
(Adverse Reactions)
Clinical Studies Experience
COREG (carvedilol) has been evaluated for safety in patients with heart failure (mild, moderate, and severe), in patients with left ventricular dysfunction following myocardial infarction and in hypertensive patients. The observed adverse event profile was consistent with the pharmacology of the drug and the health status of the patients in the clinical trials. Adverse events reported for each of these patient populations are provided below. Excluded are adverse events considered too general to be informative, and those not reasonably associated with the use of the drug because they were associated with the condition being treated or are very common in the treated population. Rates of adverse events were generally similar across demographic subsets (men and women, elderly and non-elderly, blacks and non-blacks).
Heart Failure
COREG (carvedilol) has been evaluated for safety in heart failure in more than 4,500 patients worldwide of whom more than 2,100 participated in placebo-controlled clinical
trials. Approximately 60% of the total treated population in placebo-controlled clinical trials received COREG (carvedilol) for at least 6 months and 30% received COREG (carvedilol) for at least 12 months. In the COMET trial, 1,511 patients with mild-to-moderate heart failure were treated with COREG (carvedilol) for up to 5.9 years (mean 4.8 years). Both in US clinical trials in mild-to-moderate heart failure that compared COREG (carvedilol) in daily doses up to 100 mg (n = 765) to placebo (n = 437), and in a multinational clinical trial in severe heart failure (COPERNICUS) that compared COREG (carvedilol) in daily doses up to 50 mg (n = 1,156) with placebo (n = 1,133), discontinuation rates for adverse experiences were similar in carvedilol and placebo patients. In placebo-controlled clinical trials, the only cause of discontinuation > 1%, and occurring more often on carvedilol was dizziness (1.3% on carvedilol, 0.6% on placebo in the COPERNICUS trial).
Table 1 shows adverse events reported in patients with mild-to-moderate heart failure enrolled in US placebo-controlled clinical trials, and with severe heart failure enrolled in the COPERNICUS trial. Shown are adverse events that occurred more frequently in drug-treated patients than placebo-treated patients with an incidence of > 3% in patients treated with carvedilol regardless of causality. Median study medication exposure was 6.3 months for both carvedilol and placebo patients in the trials of mild-to-moderate heart failure, and 10.4 months in the trial of severe heart failure patients. The adverse event profile of COREG (carvedilol) observed in the long-term COMET study was generally similar to that observed in the US Heart Failure Trials.
Table 1: Adverse Events (%) Occurring More Frequently With
COREG (carvedilol) Than With Placebo in Patients With Mild-to-Moderate Heart Failure (HF)
Enrolled in US Heart Failure Trials or in Patients With Severe Heart Failure
in the COPERNICUS Trial (Incidence > 3% in Patients Treated With Carvedilol,
Regardless of Causality)
Mild-to-Moderate HF | Severe HF | |||
COREG (n = 765) |
Placebo (n = 437) |
COREG (n = 1,156) |
Placebo (n = 1,133) |
Body as a Whole | ||||
Asthenia | 7 | 7 | 11 | 9 |
Fatigue | 24 | 22 | - | - |
Digoxin level increased | 5 | 4 | 2 | 1 |
Edema generalized | 5 | 3 | 6 | 5 |
Edema dependent | 4 | 2 | - | - |
Cardiovascular | ||||
Bradycardia | 9 | 1 | 10 | 3 |
Hypotension | 9 | 3 | 14 | 8 |
Syncope | 3 | 3 | 8 | 5 |
Angina pectoris | 2 | 3 | 6 | 4 |
Central Nervous System | ||||
Dizziness | 32 | 19 | 24 | 17 |
Headache | 8 | 7 | 5 | 3 |
Gastrointestinal | ||||
Diarrhea | 12 | 6 | 5 | 3 |
Nausea | 9 | 5 | 4 | 3 |
Vomiting | 6 | 4 | 1 | 2 |
Metabolic | ||||
Hyperglycemia | 12 | 8 | 5 | 3 |
Weight increase | 10 | 7 | 12 | 11 |
BUN increased | 6 | 5 | - | - |
NPN increased | 6 | 5 | - | - |
Hypercholesterolemia | 4 | 3 | 1 | 1 |
Edema peripheral | 2 | 1 | 7 | 6 |
Musculoskeletal | ||||
Arthralgia | 6 | 5 | 1 | 1 |
Respiratory | ||||
Cough increased | 8 | 9 | 5 | 4 |
Rales | 4 | 4 | 4 | 2 |
Vision | ||||
Vision abnormal | 5 | 2 | - | - |
Cardiac failure and dyspnea were also reported in these studies, but the rates were equal or greater in patients who received placebo.
The following adverse events were reported with a frequency of > 1% but ≤ 3% and more frequently with COREG (carvedilol) in either the US placebo-controlled trials in patients with mild-to-moderate heart failure, or in patients with severe heart failure in the COPERNICUS trial.
Incidence > 1% to ≤ 3%
Body as a Whole: Allergy, malaise, hypovolemia, fever, leg edema.
Cardiovascular: Fluid overload, postural hypotension, aggravated angina pectoris, AV block, palpitation, hypertension.
Central and Peripheral Nervous System: Hypesthesia, vertigo, paresthesia.
Gastrointestinal: Melena, periodontitis.
Liver and Biliary System: SGPT increased, SGOT increased.
Metabolic and Nutritional: Hyperuricemia, hypoglycemia, hyponatremia, increased alkaline phosphatase, glycosuria, hypervolemia, diabetes mellitus, GGT increased, weight loss, hyperkalemia, creatinine increased.
Musculoskeletal: Muscle cramps.
Platelet, Bleeding and Clotting: Prothrombin decreased, purpura, thrombocytopenia.
Psychiatric: Somnolence.
Reproductive, male: Impotence.
Special Senses: Blurred vision.
Urinary System: Renal insufficiency, albuminuria, hematuria.
Left Ventricular Dysfunction Following Myocardial Infarction
COREG (carvedilol) has been evaluated for safety in survivors of an acute myocardial infarction with left ventricular dysfunction in the CAPRICORN trial which involved 969 patients who received COREG (carvedilol) and 980 who received placebo. Approximately 75% of the patients received COREG (carvedilol) for at least 6 months and 53% received COREG (carvedilol) for at least 12 months. Patients were treated for an average of 12.9 months and 12.8 months with COREG (carvedilol) and placebo, respectively.
The most common adverse events reported with COREG (carvedilol) in the CAPRICORN trial were consistent with the profile of the drug in the US heart failure trials and the COPERNICUS trial. The only additional adverse events reported in CAPRICORN in > 3% of the patients and more commonly on carvedilol were dyspnea, anemia, and lung edema. The following adverse events were reported with a frequency of > 1% but ≤ 3% and more frequently with COREG (carvedilol) : Flu syndrome, cerebrovascular accident, peripheral vascular disorder, hypotonia, depression, gastrointestinal pain, arthritis, and gout. The overall rates of discontinuations due to adverse events were similar in both groups of patients. In this database, the only cause of discontinuation > 1%, and occurring more often on carvedilol was hypotension (1.5% on carvedilol, 0.2% on placebo).
COREG (carvedilol) has been evaluated for safety in hypertension in more than 2,193 patients in US clinical trials and in 2,976 patients in international clinical trials.
Approximately 36% of the total treated population received COREG (carvedilol) for at least 6 months. Most adverse events reported during therapy with COREG (carvedilol) were of mild to moderate severity. In US controlled clinical trials directly comparing COREG (carvedilol) in doses up to 50 mg (n = 1,142) to placebo (n = 462), 4.9% of patients receiving COREG (carvedilol) discontinued for adverse events versus 5.2% of placebo patients. Although there was no overall difference in discontinuation rates, discontinuations were more common in the carvedilol group for postural hypotension (1% versus 0). The overall incidence of adverse events in US placebo-controlled trials increased with increasing dose of COREG (carvedilol) . For individual adverse events this could only be distinguished for dizziness, which increased in frequency from 2% to 5% as total daily dose increased from 6.25 mg to 50 mg.
Table 2 shows adverse events in US placebo-controlled clinical trials for hypertension that occurred with an incidence of ≥ 1% regardless of causality, and that were more frequent in drug-treated patients than placebo-treated patients.
Table 2: Adverse Events (%) Occurring in US Placebo-Controlled
Hypertension Trials (Incidence ≥ 1%, Regardless of Causality)*
COREG (n = 1,142) |
Placebo (n = 462) |
Cardiovascular | ||
Bradycardia | 2 | - |
Postural hypotension | 2 | - |
Peripheral edema | 1 | - |
Central Nervous System | ||
Dizziness | 6 | 5 |
Insomnia | 2 | 1 |
Gastrointestinal | ||
Diarrhea | 2 | 1 |
Hematologic | ||
Thrombocytopenia | 1 | - |
Metabolic | ||
Hypertriglyceridemia | 1 | - |
* Shown are events with rate > 1% rounded to nearest integer. |
Dyspnea and fatigue were also reported in these studies, but the rates were equal or greater in patients who received placebo.
The following adverse events not described above were reported as possibly or probably related to COREG (carvedilol) in worldwide open or controlled trials with COREG (carvedilol) in patients with hypertension or heart failure.
Incidence > 0.1% to ≤ 1%
Cardiovascular: Peripheral ischemia, tachycardia.
Central and Peripheral Nervous System: Hypokinesia.
Gastrointestinal: Bilirubinemia, increased hepatic enzymes (0.2% of hypertension patients and 0.4% of heart failure patients were discontinued from therapy because of increases in hepatic enzymes).
Psychiatric: Nervousness, sleep disorder, aggravated depression, impaired concentration, abnormal thinking, paroniria, emotional lability.
Respiratory System: Asthma [see CONTRAINDICATIONS].
Reproductive, male: Decreased libido.
Skin and Appendages: Pruritus, rash erythematous, rash maculopapular, rash psoriaform, photosensitivity reaction.
Special Senses: Tinnitus.
Urinary System: Micturition frequency increased.
Autonomic Nervous System: Dry mouth, sweating increased.
Metabolic and Nutritional: Hypokalemia, hypertriglyceridemia.
Hematologic: Anemia, leukopenia.
The following events were reported in ≤ 0.1% of patients and are potentially important: Complete AV block, bundle branch block, myocardial ischemia, cerebrovascular disorder, convulsions, migraine, neuralgia, paresis, anaphylactoid reaction, alopecia, exfoliative dermatitis, amnesia, GI hemorrhage, bronchospasm, pulmonary edema, decreased hearing, respiratory alkalosis, increased BUN, decreased HDL, pancytopenia, and atypical lymphocytes.
Laboratory Abnormalities
Reversible elevations in serum transaminases (ALT or AST) have been observed during treatment with COREG (carvedilol) . Rates of transaminase elevations (2- to 3-times the upper limit of normal) observed during controlled clinical trials have generally been similar between patients treated with COREG (carvedilol) and those treated with placebo. However, transaminase elevations, confirmed by rechallenge, have been observed with COREG (carvedilol) . In a long-term, placebo-controlled trial in severe heart failure, patients treated with COREG (carvedilol) had lower values for hepatic transaminases than patients treated with placebo, possibly because improvements in cardiac function induced by COREG (carvedilol) led to less hepatic congestion and/or improved hepatic blood flow.
COREG (carvedilol) has not been associated with clinically significant changes in serum potassium, total triglycerides, total cholesterol, HDL cholesterol, uric acid, blood urea nitrogen, or creatinine. No clinically relevant changes were noted in fasting serum glucose in hypertensive patients; fasting serum glucose was not evaluated in the heart failure clinical trials.
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of COREG (carvedilol) . Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Reports of aplastic anemia and severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme) have been rare and received only when carvedilol was administered concomitantly with other medications associated with such reactions. Rare reports of hypersensitivity reactions (e.g., anaphylactic reaction, angioedema, and urticaria) have been received for COREG (carvedilol) and COREG (carvedilol) CR®, including cases occurring after the initiation of COREG (carvedilol) CR in patients previously treated with COREG (carvedilol) . Urinary incontinence in women (which resolved upon discontinuation of the medication) and interstitial pneumonitis have been reported rarely.
Read the entire FDA prescribing information for Coreg (Carvedilol) »
Coreg FDA Prescribing Information
Additional Coreg Information
Coreg - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.


text:
Town Square
Wente family estates achieves 'Sustainable Winegrowing' status
Original post made on Oct 27, 2010
Read the full story here Web Link posted Tuesday, October 26, 2010, 6:42 AM
Comments (2)
a resident of Kottinger Ranch
on Oct 27, 2010 at 7:55 pm
Great! They should also check out an up and coming way to distribute their product to restaurants...WINE ON TAP is the latest movement within the industry.
Check it out:
Web Link
Web Link
a resident of San Ramon
on Oct 27, 2010 at 9:30 pm
Great wine, super people and now 'Sustainable Winegrowing' status. You can't beat Wente and they are local.
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Steve Glazer for State Senate
By Roz Rogoff | 3 comments | 1,774 views
Pleasanton resident will have his hands full trying to keep the Oakland teams
By Tim Hunt | 1 comment | 973 views
The House of Representatives performs historys first repeat hara-kiri
By Tom Cushing | 2 comments | 477 views

subset: commoncrawl


text:
Rear Window
New beginning for Renaissance men
PUBLISHED: 16 Dec 2010 00:03:14 | UPDATED: 16 Dec 2010 00:03:14PUBLISHED: 16 Dec 2010 PRINT EDITION: 16 Dec 2010A couple of interesting names turned up among the top 20 shareholders of tiddler Renaissance Uranium yesterday, when the company listed on the Australian Securities Exchange.
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Companies | Renaissance Uranium, Dart Energy Ltd, Apollo Gas Ltd, Empire Beer Group |
Topics | Energy & Utilities, Metals & Mining, Company News |


text:
The rapid accumulation of genomic information in databases necessitates rapid and specific algorithms for extracting biologically meaningful information. More or less complete retroviral sequences, also called proviral or endogenous retroviral sequences; ERVs, constitutes at least 5% of vertebrate genomes. After infecting the host, these retroviruses have integrated in germ line cells, and have then been carried in genomes for at least several 100 million years. A better understanding of structure and function of these sequences can have profound biological and medical consequences.
RetroTector© (ReTe) is a platform-independent Java program for identification and characterization of proviral sequences in vertebrate genomes. The full ReTe requires a local installation with a MySQL database. Although not overly complicated, the installation may take some time. A "light" version of ReTe, (RetroTector online; ROL) which does not require specific installation procedures is provided, via the World Wide Web.
ROL http://www.fysiologi.neuro.uu.se/jbgs/ webcite was implemented under the Batchelor web interface (A Lövgren et al). It allows both GenBank accession number, file and FASTA cut-and-paste admission of sequences (5 to 10 000 kilobases). Up to ten submissions can be done simultaneously, allowing batch analysis of <= 100 Megabases. Jobs are shown in an IP-number specific list. Results are text files, and can be viewed with the program, RetroTectorViewer.jar (at the same site), which has the full graphical capabilities of the basic ReTe program. A detailed analysis of any retroviral sequences found in the submitted sequence is graphically presented, exportable in standard formats. With the current server, a complete analysis of a 1 Megabase sequence is complete in 10 minutes. It is possible to mask nonretroviral repetitive sequences in the submitted sequence, using host genome specific "brooms", which increase specificity.
Proviral sequences can be hard to recognize, especially if the integration occurred many million years ago. Precise delineation of LTR, gag, pro, pol and env can be difficult, requiring manual work. ROL is a way of simplifying these tasks.
ROL provides 1. annotation and presentation of known retroviral sequences, 2. detection of proviral chains in unknown genomic sequences, with up to 100 Mbase per submission.
Genomic databases are growing dramatically. Not only are reference genomes from many organisms sequenced, the probable coming era of "personal genomics" will lead to further substantial increases. The demand for rapid and easily accessible pattern recognition tools increases concomitantly. More or less complete retroviral sequences make up a substantial part of vertebrate genomes. After infecting the host, these retroviruses have integrated in germ line cells, and have then been carried in progeny genomes for long times. Recently integrated retroviruses may still produce viral particles and could be associated with diseases. However, most ERVs are mutated to viral inactivity. Some are beneficial for the host where for example they can provide promoter elements or proteins (for a review, see [1]) Because of mutations retroviral sequences can be difficult to detect, especially the older elements which can lack recognisable retroviral protein. A better understanding of the structure and function of these sequences can have profound biological and medical consequences.
The full version [2] of ReTe requires a local installation with a MySQL database. The basic principle of ReTe is "fragment threading". A collection of conserved motifs (mostly from proteins) are tested against the sequence to be evaluated. A chaining algorithm stitches together motif hits, which conform to limits specified in an intermotif distance table, to a "retroviral chain" which best fits the retroviral genus, distances and degree of motif similarity. Each chain is given a "retroviral score" which in essence describes the degree of conformity to a retroviral structure model. Protein translations ("puteins") are interpreted with the help of several algorithms, one being the degree of fit to an alignment of reference retroviral proteins, others focused on finding the starts and ends of the protein. In problematic cases, alternative chains and alternative putein interpretations are given. Unlike most other retrovirus-finding algorithms, ReTe is not dependent on repetition, neither of LTRs nor of proviruses. It is therefore especially important for finding low copy number proviruses, like ERVFc1 [3].
The ReTe installation may take some time for unexperienced users. With the latter in mind, we have now created a "light" version of ReTe, ROL. ROL uses the same collection of conserved motifs and the same intermotif distance table as ReTe. The results of ROL should be the same as with ReTe. However, ReTe contains several additional features, like LTR divergence, nucleotide frequency and most similar reference sequences, which are not present in ROL.
ROL does not require specific installation procedures. It can be accessed via the World Wide Web. ROL was implemented under the Batchelor web interface (A. Lövgren et al, unpublished). Batchelor is written in PHP and designed to act as a wrapper around an existing standalone application and to integrate it with the web. As a batch queue manager, Batchelor allows jobs with long run times to be submitted to the web server and scheduled for later execution by its batch queue. Users (submitters) can monitor the state of their submitted jobs (pending, running or finished) and later download the result from the queue view. The user interface is customizable through templates and extendable through user defined callback functions. Among its features are job control, statistics and (in latest releases) web service interfaces. ROL and Batchelor run on a Dell PowerEdge 2950 server with 2 × Quad Core Xeon 2.50 GHz processors, 8 GB RAM with a 64-bit Gentoo Linux operative system.
The RetroTector online implementation
The ROL implementation http://www.neuro.uu.se/fysiologi/jbgs webcite, under the Batchelor web interface, allows both GenBank accession number, file and FASTA cut-and-paste admission of sequences (5 to 1000 000 kilobases) (Figure 1). Up to ten submissions can be done simultaneously. Thus, a batch analysis of <= 100 Megabases can be specified in one instance. Jobs are shown in an IP-number specific list. Results are downloadable as text files. The text files derive from 100 000 base chunks. Names of chunks which contain one or several retroviral chains detected by ReTe are shown in bold face. Each retrovirus-positive chunk can be inspected by means of the stand-alone program, RetroTectorViewer.jar, which has the full graphical capabilities of the basic ReTe program. It can export in EPS, PDF and JPG formats. Thus, a detailed analysis of any retroviral sequences found in the submitted sequence is graphically presented. With the current server, a complete analysis of a 1 Megabase sequence is complete in under 10 minutes. It is possible to mask nonretroviral repetitive sequences in the submitted sequence before analysis, using host genome specific "brooms". This increases the specificity of the analysis.
Figure 1. User interface of RetroTector online. FASTA formatted sequences, each up to 10 Mbases long, can be entered as file, by cut-and-paste, and by GenBank accession number. Up to ten sequences can be entered at the same time.
An example (Figure 2) is the analysis of ERVFc1, a gammaretroviruslike sequence which has several ORFs and near-ORFs [1,3]. This low copy number sequence was present in previous assemblies of the human genome, but has been edited out of the hg18 assembly. The provirus shown is from the panTro2 chimpanzee genome assembly. This illustrates the importance of independent retrovirus sequence detection systems, like ReTe and ROL.
Figure 2. Result from a run of the chimpanzee genome (panTro2). The chimpanzee version of the human HERVFc1 retroviral sequence [3] is shown. The components LTR (5 LT & 3 LT), primer binding site (PBS), gag (internal structural proteins; motifs named CA and NC), pro (protease, motifs named PR), pol (pol gene, motifs named RT, RH and IN), env (envelope gene, motifs named SU and TM), and polypurine tract (PPT) are shown. Figures above each motif denote its score (0–100). The following features are also predicted: Red bars denote stop codons, blue bars start codons. Triple lines denote putative protein encoding sequences. Green bars denote putative asparagine glycosylation sites, "/" splice donor, "\ " splice acceptor, "S" "Slippery" sequence (possible frameshift sites), and "8" pseudoknot sequences (which are also possible frameshift sites).
Several pattern recognition algorithms for recognition of retroviral sequences exist ([4-9]; for a review, see [1]). The algorithms generally have a specific purpose. Either they emphasize LTRs, repetitiveness, conserved motifs, or open reading frames. A combined search therefore may be called for. ReTe is unique in its detailed analysis of the internal proviral sequences and classification of the provirus. It is modular, which allows users to add their own program modules. Despite the existence of several programs for detection of retroviral sequences, a number of problems remain. Several portions, especially the long terminal repeats (LTRs), of retroviral genomes do not encode proteins. The detection of noncoding nucleic acid sequences is a specific instance of the more general problem of pattern recognition. The methods used in ReTe for LTR detection are mainly artificial neural networks and heuristic motif combinations [10]. These are combined with detection of conserved protein coding motifs and reading frames using pairwise and multiple amino-acid alignments. ReTe is mainly targeted to higher vertebrate genomes. For analysis of other genomes, a further optimization for detection of Meta- and Pseudoviridae sequences (also known as gypsy and copia-like sequences, respectively) is necessary. These retrovirus-related sequences are abundant in lower vertebrates, insects and plants, among others. ROL is intended for analysis of 5–10 000 Kbases of genomic sequence. For example, a batch job of 10 different cosmid sequences of 1–2 Mbases can be specified via a list of their GenBank accession numbers. Sequences of entire small chromosomes, like human chromosomes 20, 21 and 22 can be entered via cut-and-paste, accession number or as a downloaded file.
The sensitivity and specificity of ROL is the same as that of ReTe. However, a judgement regarding the choice of "brooms" must be made. Brooms are a set of preselected nonretroviral repetitive sequences prevalent in the host genome under study. Currently, brooms for higher primate, artiodactyl, rodent, bird and marsupial genomes are available at the ROL site. The brooms remove many of the weak false signals from LTR-like sequences. LTRs are difficult to detect because they usually do not code for proteins and therefore contain very few conserved motifs detectable by the unaided eye. In addition some parts of the LTRs consist of repetitive elements like C-rich or GT-rich regions that can easily be matched by other repetitive elements like ALUs. This can spur incorrect chain formation by ReTe and can result in poor detection specificities. The user may experiment with different brooms to obtain an optimal result.
ROL offers a convenient way to quickly search for, annotate and present retroviral sequences in genomic sequences.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
GS wrote the ReTe and RetroTectorviewer Java code, and oversaw the implementation of ROL. AL wrote the Batchelor web presentation and batch processor, and adapted it to create ROL. NEE participated in the design and conception of ROL. FB participated in the writing of the manuscript. JB is the retrovirologist behind ReTe, tested the user interface, provided ideas on useful features and participated in the writing of the manuscript.
We thank the head of the Uppsala BioMedical Centre, ass. prof. Catharina Svensson, for providing a suitable server as a host for ROL.
This article has been published as part of BMC Bioinformatics Volume 10 Supplement 6, 2009: European Molecular Biology Network (EMBnet) Conference 2008: 20th Anniversary Celebration. Leading applications and technologies in bioinformatics. The full contents of the supplement are available online at http://www.biomedcentral.com/1471-2105/10?issue=S6.
Blikstad V, Benachenhou F, Sperber GO, Blomberg J: Evolution of human endogenous retroviral sequences: a conceptual account.
Cell Mol Life Sci 2008. PubMed Abstract | Publisher Full Text
Sperber GO, Airola T, Jern P, Blomberg J: Automated recognition of retroviral sequences in genomic data – RetroTector.
Nucleic acids research 2007, 35(15):4964-4976. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Benit L, Calteau A, Heidmann T: Characterization of the low-copy HERV-Fc family: evidence for recent integrations in primates of elements with coding envelope genes.
Virology 2003, 312(1):159-168. PubMed Abstract | Publisher Full Text
McCarthy EM, McDonald JF: LTR_STRUC: a novel search and identification program for LTR retrotransposons.
Bioinformatics 2003, 19(3):362-367. PubMed Abstract | Publisher Full Text
Villesen P, Aagaard L, Wiuf C, Pedersen FS: Identification of endogenous retroviral reading frames in the human genome.
Retrovirology 2004, 1(1):32. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Jurka J, Klonowski P, Dagman V, Pelton P: CENSOR – a program for identification and elimination of repetitive elements from DNA sequences.
Comput Chem 1996, 20(1):119-121. PubMed Abstract | Publisher Full Text
Jurka J, Kapitonov VV, Pavlicek A, Klonowski P, Kohany O, Walichiewicz J: Repbase Update, a database of eukaryotic repetitive elements.
Cytogenet Genome Res 2005, 110(1–4):462-467. PubMed Abstract | Publisher Full Text
de Parseval N, Lazar V, Casella JF, Benit L, Heidmann T: Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.
Journal of virology 2003, 77(19):10414-10422. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Smit AF: Interspersed repeats and other mementos of transposable elements in mammalian genomes.
Curr Opin Genet Dev 1999, 9(6):657-663. PubMed Abstract | Publisher Full Text
Durbin R, Eddy S, Krogh A, Mitchison G: Biological Sequence analysis. Cambridge: Cambridge University press; 2005.


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Kona and Hilo (Big Island of Hawaii) hotels
Kona and Hilo (Big Island of Hawaii) is a popular getaway vacation in United States for local and foreign tourists. HotelClub has 47 cheap accommodation options available for booking in Kona and Hilo (Big Island of Hawaii). Recommended hotels in Kona and Hilo (Big Island of Hawaii) are highly rated by reviewers for their Amenities and Room cleanliness.
47 hotels in Kona and Hilo (Big Island of Hawaii), Hawaii
Travellers looking for a posh Hawaiian vacation in the Big Island book a stay at Sheraton Kona Resort & Spa at Keauhou Bay. This luxurious leisure complex at Keauhou Bay provides guests an ideal... More
Offering a myriad of activities and tranquil environment, the Kona Coast Resort Hawaii makes your stay pleasurable and a moment to be cherished. GeneralHead out to sea for some of the best water... More
Hilton Waikoloa Village offers luxurious accommodation and unmatched facilities for a relaxing stay. Surrounded by amazing gardens, rich wildlife, and tranquil waterways, this property is an... More
Paniolo Greens Resort offers luxurious accommodation and services for travellers in Waikoloa. Being on the beachfront, this resort has a number of activities to offer to visitors. Guests can enjoy... More
Nestled in mountains near the coastline of Pacific Ocean, The Mauna Lani Bay Hotel & Bungalows Kohala Coast makes for suitable base for romantic getaways and family vacations in Hawaii. Aside from... More
Travel away from the bustle of city living and enjoy a fun-filled tropical escape by booking a stay in the comfortable and well-located accommodations of Castle Hilo Hawaiian Hotel. Aside from... More
The Royal Kona Resort is an architectural marvel set on twelve oceanfront acres, offering an impressive range of amenities for a fabulous stay. GeneralFor the comfort of business guests, the... More
Offering spectacular resort scenery, including gorgeous waterfalls and sweeping oceanfront views, this resort provides an unforgettable backdrop to any special event or celebration. GeneralThe... More
Perfectly nestled into the bluffs above Hapuna Beach, the hotel presents a flowing, contemporary Hawaiian style where guests experience the true essence of rejuvenation. General You'll find over... More
Being an oasis of peace and calm, this property offers a pleasant ambience, high standards of comfort and island style hospitality for a wonderful vacation. GeneralAt leisure, you can have a... More
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In Pictures: 2014's biggest Cloud deals (so far)
The most important cloud acquisitions this year have one thing in common: OpenStack.
Security researchers are urging users to install new Samba security updates in order to address a critical vulnerability that allows attackers to execute arbitrary code with root privileges.
Remote code execution vulnerabilities in the standard implementation of the network time protocol (NTP) can be exploited by attackers to compromise servers, embedded devices and even critical infrastructure systems that run UNIX-like operating system...
The "grinch" Linux vulnerability that Alert Logic raised alarms about Tuesday is not a vulnerability at all, according to Red Hat.
The most important cloud acquisitions this year have one thing in common: OpenStack.
System administrators who spent last week making sure their computers are patched against Shellshock, a critical vulnerability in the Bash Unix command-line interpreter, will have to install a new patch that addresses additional attack vectors.
Contributing to open-source projects can give software developers an edge over other applicants in the competitive IT job market, say hiring professionals.
Coming up with a great technology product or service is only half the battle these days. Creating a name for said product that is at once cool but not too cool or exclusionary, marketable to both early adopters and a broader audience, and, of course,...
The latest business news, reviews, features and whitepapers
Visit our shop for the best deals on hot products
Watch our video news and reviews from around the world
Comprehensive buying guides, features, and step-by-step articles
First impression on unpacking the Q702 test unit was the solid feel and clean, minimalist styling.
For work use, Microsoft Word and Excel programs pre-installed on the device are adequate for preparing short documents.
The Fujitsu LifeBook UH574 allowed for great mobility without being obnoxiously heavy or clunky. Its twelve hours of battery life did not disappoint.
The screen was particularly good. It is bright and visible from most angles, however heat is an issue, particularly around the Windows button on the front, and on the back where the battery housing is located.
My first impression after unboxing the Q702 is that it is a nice looking unit. Styling is somewhat minimalist but very effective. The tablet part, once detached, has a nice weight, and no buttons or switches are located in awkward or intrusive positions.


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Party Themes
Looking for the perfect party theme for your event? Finding the right one can be a challenge, especially if you have small children. At Designed 2B Sweet, are delighted to offer a variety of different party designs, ideas, and themes to make life easier for parents. We offer some of the hottest decorations out there to make planning your party simpler and easier, from pirates and superheroes, to animal and even princess themes. Best of all, we offer a variety of different designs ,allowing you and your child to pick the right party theme for your child's personality and specific wants.
Best of all, you can find just about any type of tableware, decorations, and even toys to fit your theme, making sure that your child has the birthday party of their dreams. As well, you can mix and match different items with various party themes, depending on color and design, allowing you to create something unique for your own party. With our large selection of party decorations, costume accessories, tableware, and party favors, we think you will find exactly what you need to create the party theme of your child's dreams, allowing you to create picture perfect memories with our unique and fun collections.
Princess Wand & Tiara Set
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Party Bling Necklaces (12 pc)
Regular Price: $25.26
Now only: $16.59
Silver Chinese Takeout Boxes - Favor Containers (5 pc)
$8.99 -
Princess Wand Pens (1 dz)
$8.99 -
Monster Trucks Beverage Napkins (16 pc)
$5.60 -
Monster Trucks Dinner Plates (8 pc)
$7.85 -
Monster Trucks Luncheon Napkins (16 pc)
$5.85 -
Viking Rubber Duckies (1 dz)
$8.99 -
Mini Star Fairy Princess Wands (1 dz)
$5.20 -
Silver Rose Petals (approx 200)
$5.70 -
Silver Sequin Fedora (1 pc)
$8.65 -
Silver Gangster Hat (1 dz)
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Two Hearts Wedding Centerpiece
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Bride Iron On Rhinestone Decal with Hearts
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Two Hearts Cocktail Napkins (50 pc)
$9.49 -
Silver Heart Thank You Stickers (1 roll)
$6.25 -
Two Hearts Wedding Inflatable Buffet
$19.98 -
Two Heart Wedding Favor Boxes (1 dz)
$12.99 -
Sequin Newsboy Hat Diva Hat
$5.75 -
Sequin Baseball Cap
$5.75 -
Pewtertone Metal Nail Cross Necklace Craft Kits (1 dz)
$11.11 -
Silver Star Decorations (1 dz)
$5.39 -
Dangling Silver Star Swirls (1 dz)
$7.50 -
Foil Silver Stars (1 dz)
$9.35 -
Silver Star Shaped Confetti
$6.89 -
Police Costume Handcuffs (1 dz)
$15.82 -
Metal Double Lock Handcuffs w/Keys (1 pc)
Regular Price: $8.36
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Guitar Bling Necklaces (1 dz)
Regular Price: $25.26
Now only: $16.59
Rhinestone Queen Tiara (1 pc)


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Peggy Post's Golden Rules of E-Mail Etiquette
By Peggy Post
Special Offers
E-Mailing a Friend
To: sarah email@example.com, email@example.com, email@example.com, firstname.lastname@example.com, BCThayert@orjo/usa.com, firstname.lastname@example.com, firstname.lastname@example.com (Jane Berry), firstname.lastname@example.com 1 cc: Subject: LOL what's up ladies?! I haven't talked to some of you in ages, 2but someone just sent me this joke and I knew it was too good not to share. 3Pass it on to 10 of your closest friends, esp. those who need (::[]::), or you will be cursed for life! This y/x:-)4 walks into a bar and sees this really pretty woman. His wife told him he can't kiss anyone on the lips, so he asks if he can KOTC. She says sure ;). So he grabs her hips. She says what are u doing? And he says, well, u said I could kiss your cheek, but you didn't say which one! LOL! Best joke in a while. Miss u lots. Let's get together this summer! -JJ |
1. Don't show addresses. Privacy is important. When you send group mailings, it's likely that you are exposing everyone's e-mail address. No big deal? Think again. Some people equate this with giving their home phone number to a telemarketer, so before you include someone in your group list, ask permission. Better yet, some e-mail programs allow you to set up group mailings that do not display individual e-mail addresses to others.
2. Jokes aren't for everyone. What's funny to you might offend someone else even a friend or family member so carefully consider to whom you are sending anything off-color. If you haven't shared a laugh over this kind of material before, think twice before firing off the e-mail.
3. Chain e-mails are annoying. People who are inundated with electronic messages often feel bothered, not flattered, when they receive pass-along jokes and chain letters. Check with the recipient before sending messages of this nature.
4. What the heck are you saying? Keep emoticons and acronyms to a minimum. Many people are unfamiliar with e-mail slang and find it annoying. Save these gimmicks for the true techies in your life.
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The Robotic Vacuums Worth Your Money
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Press Contacts
- Leticia Linn, Tel. 202 974 3440
- Sebastiãn Oliel, Tel. 202 974 3459
- Sonia Mey Schmidt, Tel 202 974 3036
Drains & You: A Manual for Drainage Maintenance Workers
This manual is useful not only for drainage workers engaged in cleaning and repairing secondary drains, working for ministries and local governments, but also for the general public in making them aware of the role drains play in public health and safety. In the latter sense, it serves as a social-communication tool to raise community awareness of the general public of domestic-sanitation issues and their effect on public health. This page offers the entire manual for field use, with chapters downloadable in PDF. (30/Mar/2000)
In English (4.17k)


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Wallenius Wilhelmsen Logistics welcomes into operation the M/V Thermopylae, the first of its new generation of Post Panamax HERO (High Efficiency RoRo) PCTC vessels.
The Munkebo Maersk became the largest ship to ever sail up the River Thames as it called at DP World London Gateway, the U.K.'s newest deep-sea port hub. The 399-meter-long,
Rolls-Royce has been selected to supply waterjets and high speed MTU diesel engines to power two new aluminium catamaran fast ferries for Chinese ferry operator
Port of Los Angeles container volumes decreased by 22.7 percent in January compared to January 2014 volumes, the port announced today. The port's January 2015 cargo volumes totaled 529,


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Welcome to the Parameira google satellite map! This place is situated in Arouca, Entre Douro e Vouga, Norte, Portugal, its geographical coordinates are 40° 58' 0" North, 8° 25' 0" West and its original name (with diacritics) is Parameira. See Parameira photos and images from satellite below, explore the aerial photographs of Parameira in Portugal. Parameira hotels map is available on the target page linked above.
This map is informational only. No representation is made or warranty given as to its content. User assumes all risk of use. Maplandia.com assumes no responsibility for any loss or delay resulting from such use.
Do you like this map? Link to it or recommend it!
Register at Parameira or add new placemark for Parameira.
Get your personal map homepage and much more for free.
Maplandia.com in partnership with Booking.com offers highly competitive rates for all types of hotels in Parameira, from affordable family hotels to the most luxurious ones. Booking.com, being established in 1996, is longtime Europe's leader in online hotel reservations.
At Maplandia.com you won't be charged any booking fees, cancellation fees, or administration fees – the reservation service is free of charge. The reservation system is secure and your personal information and credit card is encrypted.
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The location of each Parameira hotel listed is shown on the detailed zoomable map. Moreover, Parameira hotel map is available where all hotels in Parameira are marked. You can easily choose your hotel by location.
Many photos and unbiased Parameira hotel reviews written by real guests are provided to help you make your booking decision.
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We search over 500 approved car hire suppliers to find you the very best Parameira rental prices available. You can compare offers from leading car hire suppliers like Avis, Europcar, Sixt or Thrifty as well as budget rental deals from Holiday Autos, Budget, Economy, EasyCar, or 121 carhire. Choose Parameira car hire supplier according to your preferences. The booking process is secured and is made as simple as possible. You don't have to browse through several websites and compare prices to find cheap car rental in Parameira — we will do it for you!
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Radio Frequency Interference (RFI)
A Ham's Guide To RFI, Ferrites, Baluns, And Audio Interfacing by Jim Brown, ... E- book-"The RSGB Guide to EMC" (Electromagnetic Compatibility); NARTE ... Learn More
Results 49 - 56 of 826 ... Adding updates and new material for the 3rd Edition of the RFI Book. .... Mr. Gruber reports he was able to locate two noise sources during ... Learn More
Forum » General Technical Q & A » Noise reduction
Back when we were doing the first ARRL RFI Book, Bob Schetgen, KU7G (SK), the RFI Book ediror, poo-poo'd the warning I wanted to put in ... Learn More
Order by Mail
This book set includes popular ARRL publications, intended for clubs or individuals ... $29.95. #0823. Understanding Basic Electronics. $32.95. #0915. RFI Book. Learn More
Products And Other Resources
ARRL EMI/RFI Products And Other Resources. General Information on Radio Frequency ... EMC Books and Publications+. The ARRL RFI Book, American Radio ... Learn More
Jul 19, 2008 ... Write and publish the ARRL RFI Book. • Design and update ARRL's RFI web pages. • Maintain a database at ARRL to facilitate EMC case ... Learn More
Forum » User Profile » W1MG
RFI from HVAC Systems, Sep 1st 2011, 19:08, 2, 1,495, on 1/9/11 ... The RFI Book has a detailed explanation, but building one is a pretty simple matter. Learn More
May 16, 2006 ... Write and publish the ARRL RFI Book. • Design and update ARRL's RFI web pages. • Maintain a database at ARRL to facilitate EMC case ... Learn More
Forum » Antennas, feed lines, baluns and antenna tuners » tvi
Although this problem is covered in more depth on page 19.9 of the 3rd edition ARRL RFI Book, here are some things that you can try… Learn More
Interference Primer - Parts 1 and 2 Derived from QST Lab Notes ...
term for TVI, RFI, BCI and any other form of electromagnetically generated interference. Regardless of ..... The best one is the ARRL book, The ARRL RFI Book. Learn More


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Only a very small percentage of manuka honey is shown to contain the bioactive manuka factor responsible for this New Zealand honey�s antibacterial activity. Seasonal Immunity contains manuka honey that is tested and certified to naturally possess the same active antiseptic properties as a 15% phenol solution. Cryogenically processed for maximum bioactivity.
Only the super-potent mycelia of Turkey Tails Mushrooms are used to naturally maximize bioactive enzymes, polysaccharides and protein-bound polysaccharides, including beta-D-glucans, which help support immune-enhancing activities.
Natural organic Vitamin C from Brazilian acerola cherries grown on certified organic small-plot farms are hand-picked when color indicates peak potency. Each daily dose provides 107% of the recommended daily value for Vitamin C. Seasonal Immunity - pure, fresh and bioactive just like Nature intended. 100% Vegetarian.
Organic Rice Maltodextrin, Organic Gum Acacia, Organic Rice Flour, Organic Rice Concentrate, Organic Rice Extract.
As a dietary supplement for adults, take 3 tablets daily with a meal or as directed by a healthcare professional.
Do not use if you are pregnant or nursing. Keep out of reach of children.
I've tried several different Ginseng products and this is by far my favorite. It does have a positive therapeutic effect. I've had no negative side effects.
This Cider extract is very spicy, so it's easier to take if you mix it in some tomato or V8 Juice. Take at the first sign of a cold.
The company advertised an 8 oz. bottle of Wild Cherry Bark Syrup for $4.97. It also advertised an 8oz. bottle with several different herbs added for $9.45. The both bottles are identical if you read the labels. I ordered 4 of the $4.97 bottles and received 4oz. bottles. They did send me a return label but now claim they didn't receive the return pkg. And they don't have the items i ordered in stock contrary to their internet site which said both in stock. Needless to say i will never use this company again.
Cinnamon 1000 mg Natural Dietary Supplement Capsules By Mason - 100 Ea
Our Price:$5.02
North American herb and spice Oreganol P73 cream - 2 oz
Our Price:$20.32
Futurebiotics 30 day beauty secret advanced womans formula - 30 ea
Our Price:$10.14
Mason Natural menopause trio black cohosh, flaxseed and soy caplets - 30 ea
Our Price:$10.83


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Is Seafoam a good injector cleaner and if so, how should it be used?
Is Seafoam a good injector cleaner and if so, how should it be used?
Run it in the tank as a shock treatment..... Or mix 1 gal of gas to 1 can of seafoam in a gas can.... Take your fuel line off the tank on your boat. Then put it in the mixed gallon... Run it on the hose at 1500 rpms untill the mix is gone....
Lil' video; http://www.photodex.com/sharin...alb=0
It might be a TPS adjustment.. Not sure though... Do the 1 gal shock treat and see what happens first... It can't hurt. I wish I knew more, But I don't!
Lil' video; http://www.photodex.com/sharin...alb=0
I put a bottle of Seafoam in my gas tank from time to time....I use Ring Free always but around Quarterly I put in a bottle of Seafoam for kicks..Problem free


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Monday, March 2, 2015
Alternate Name: Chris Howes, Crissy Jo Howes, Crissy Howes
A daily updated summary of the week in TV.
Go to Complete Biography »
From All Movie Guide:
See Complete Filmography »
© 2010 Baseline, All rights reserved.
© 2010 All Media Guide, LLC Portions of content provided by All Movie Guide ®, a trademark of All Media Guide, LLC


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By Keith Laing - 03/19/14 09:41 AM EDT
The response of emergency personnel to the shooting at the Los Angeles International Airport was "simply unacceptable," Rep. Maxine Waters (D-Calif.) said Wednesday.
Waters' comments followed the release of a critical report by the Los Angeles World Airports (LAWA) reviewing the circumstances that surrounded the Nov. 1 LAX shooting, which resulted in the first death of an on-duty Transportation Security Administration (TSA) since the agency's inception in 2002.
Waters said the report "explains how problems in coordination between various police and fire departments resulted in multiple command posts at different locations that did not unify for 45 minutes.
Waters said it was incumbent on Los Angeles officials to make improvements to their emergency communications systems because LAX is the third-busiest airport in the U.S.
"The emergency response failures included in this report are simply unacceptable," Waters said. "I expect to hear more from LAWA on how the recommendations in this report will be implemented and what other measures will be taken to improve emergency response protocols and protect the millions of people who frequent this airport."
The LAX shooting occurred when a gunman opened fire in the airport's Terminal 3 on the morning of Nov. 1, resulting in the death of TSA Security Officer Gerardo Hernandez.
The shooting jolted the U.S. aviation industry, causing some TSA supporters to revive calls for the agency's workers to be armed at airport security checkpoints.
"Without a coordinated law enforcement response, functional equipment and police protection on the scene, TSOs in Terminal 3 that day were sitting ducks," American Federation of Government Employees David Cox said in a statement.
"With such a blatant lack of support for TSO safety, it is only by the grace of God that more damage was not done that day," Cox continued. "We are calling on TSA to create a new unit of armed TSA law enforcement officers to defend our nation's airport screening areas around the clock. This will ensure a consistent, professional, and coordinated response in the event an incident like this occurs again."
The full LAWA report on the Los Angeles airport shooting can be read here.


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From: Chuck Esterbrook <echuck@mi...> - 2000-07-12 22:06:05
The problem was that upon successful log in to my web site, I was: 1. setting a cookie to identify the user 2. invoke sendRedirect() However, sendRedirect() was clearing cookies. I've changed it so that it doesn't and updated it's docs. I also added methods clearCookies() and clearHeaders() to HTTPResponse. -Chuck |


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Thursday, 6 August 2009
A tribute to Harry Patch
For a tribute to Harry Patch in the words of my grandfather, the 'lost' war poet of Somerset, please visit Westcountry Miscellany.
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Heidi Klum and Family in Aspen Pictures
Heidi Klum, Seal, and Family Hit the Slopes in Aspen
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Heidi Klum, Seal, and Family Hit the Slopes in Aspen
Heidi Klum pulled along her daughter Lou in a sled during an family outing in Aspen on Monday. Heidi and Seal brought the kids to Colorado for Christmas, and the whole crew was spotted enjoying the Winter wonderland. Heidi also tweeted a sweet photo of her slopeside PDA with Seal during a break from snowboarding. Leni tried out her hand at skiing as well. The Klum-Samuels are just some of the famous faces who picked Aspen this holiday season. Mariah Carey stepped out in a full spandex ski suit over the weekend and Goldie Hawn and Kurt Russell hosted their annual getaway with kids Kate, Oliver, and their families.
Read More Lou SamuelLeni SamuelCelebrity CouplesHenry SamuelJohan SamuelSealHeidi KlumCelebrity Babies
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- Sara Gilbert welcomes a baby boy with Linda Perry — Us Weekly
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- Kelly Clarkson: "I don't care if my children are gay" — ET
- James Franco explains his creative process — JustJared
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My daughter was a student in Granada and this hotel ended up being closest to where she lived so I decided to book here for convenience. Upon arrival I realized that this was much better than I had imagined it would be. It's a small, comfortable hotel. The rooms are very nicely furnished, clean and very spacious. I stayed a... More
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- TripAdvisor is proud to partner with Expedia, Booking.com, Orbitz, Hotels.com, Despegar.com, Travelocity, Agoda, HostelBookers, Priceline, TripOnline SA, Odigeo and Tingo so you can book your Reino de Granada Hotel reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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The Grand Parade (of the 20th Century)
Presented by ArtsEmerson at Paramount Center
April 30 - May 3, 2015
The Grand Parade (of the 20th Century) depicts major events of the 20th century in a theatrical style inspired by famed artist Marc Chagall's kaleidoscopic vision of humanity at play, at war and at rest. Trapeze, circus, dance, projections and popular culture fill the height and breadth of the stage in a spectacle of history populated by people and animals in acts of grace and destruction. History is recounted with a variety of iconic images from film, television and photography. It's a glorious work of memory, memorial and celebration that shows us to ourselves and makes us consider where we are now by examining where we have come from.
559 Washington Street
Boston, MA 02111
Admission Info:
Tickets start at $25
General Day and Time Info:
Runtime: 53 minutes with no intermission
Individual Dates & Times: *
Apr 30, 2015: 7:30 pm - 8:25 pm (Thu)
May 1, 2015: 8 pm - 8:55 pm (Fri)
May 2, 2015: 8 pm - 8:55 pm (Sat)
May 3, 2015: 2 pm - 2:55 pm (Sun)
* Event durations (if noted) are approximate. Please check with the presenting organization or venue to confirm start times and duration.
Phone: 617.824.8400
Accessibility Information:


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MLB Baseball - Preview
St. Louis Cardinals vs. Arizona Diamondbacks | |
The St. Louis Cardinals and the Arizona Diamondbacks will both be trying to pick up a win on Monday when they battle at Chase Field. Adam Wainwright will be the starting pitcher for the Cardinals on this day. Righthander Wainwright is 0-0 this season with a 0.00 ERA. Meanwhile, it'll be Ian Kennedy who starts for the Diamondbacks. Righthander Kennedy is 0-0 with a 0.00 ERA so far this season. In their last action, St. Louis was a 9-0 loser on the road against the Giants. Bettors on San Francisco at -131 on the moneyline collected their winnings from that game, while the total score (9) sent OVER bettors home happy as well. Last time out for Arizona, they were a 2-1 loser as they battled the Rockies at home. Moneyline bettors who got the Rockies at +190 were rewarded, while the 3 combined runs moved the game UNDER for totals bettors. Team records:St. Louis: 0-0 SU Arizona: 0-0 SU St. Louis most recently: When playing on Monday are 7-3 Before playing Arizona are 6-4 After playing San Francisco are 3-7 After a loss are 8-2 Arizona most recently: When playing on Monday are 4-6 Before playing St. Louis are 3-7 After playing Colorado are 6-4 After a loss are 7-3 A few trends to consider: Arizona home to St. Louis, Tuesday, April 2 |


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Farah and Fariq were like two roses standing tall together in a vase full of crystal-clear water," explains Julie New, author of Who Are The Flowers In Your Garden? "Then what happened? Their daughter came along. Farah set up her business and Fariq's career became important. They had challenges and bereavements and the focus went away from them as a couple. The water in their vase started to evaporate and the petals of the roses started to fall off.
"They have grown as people and hopefully gone from being cut roses in a vase to something much more sustainable. However, every plant needs nurturing. We all need the right nutrients so we can grow and flourish again."
Life & Style | Relationships
Spice up your marriage
Most marital relationships begin to fade over time. But there are ways to keep the sparkle alive, says Christine Fieldhouse
- Image Credit: Supplied picture
- Work out what you want from your partner. We get what we think about, so when we say we don't want a cruel man, we're likely to get one because that's what we're thinking about. When we think about a kind, considerate person, we're far more likely to attract one.
Julie, who is known as The Relationship Gardener, recommends couples start by taking the time to talk – just going out for a meal together or borrowing a dog and going for a walk can create some talking space.
"We have two ears and one mouth and we should use them in that proportion," says Julie. "Talk about your needs and what you like or want. Often, our spouses get it wrong. They may bring us flowers when all we want is a cuddle, or they may organise a big night out when all we really want is a quiet cosy evening at home together. We're not mind-readers – we all need some pointers, no matter how well we think we know someone."
Psychological therapist and clinical hypnotherapist Lesley Broadhead agrees. She says relationships go through different phases – the perfect phase when we've just met and we look at our partner through rose-tinted spectacles lasts about four months and turns into the imperfect phase when we start to see their flaws and decide whether to accept them. This stage is followed by a time when we state what we want from the relationship, then there's commitment and finally there's a long-term phase. Like most married couples, Fariq and Farah are now in the long-term phase of their relationship, but, according to Lesley, they don't have to rule out romance. She says that to re-ignite a long-standing marriage, we need to understand the difference between masculine and feminine energy – and use some time-old tactics.
Learn to leave space
"We're basically still animals and we're still running with cave man functions most of the time," explains Lesley. "Traditionally, masculine energy is about giving, hunting and preying. Men like to chase. Masculine energy is about thinking. In a work situation everyone has masculine energy – we wear suits and we're efficient and competitive. Feminine energy is the opposite – it's about feelings.
"Time and time again, we see women making the big mistake of being constantly available for him. Even within a marriage, men need to feel they're the hunters and they need to win their wives' attention.
"When he appears to back off, she goes forward in pursuit of him and does as much to please him as she can. My advice to any woman is, leave space for a man to step into. This applies to any relationship between a man and a woman, no matter how long they've known each other.
"If a woman is unhappy about something, she can simply state, 'I feel unhappy'. Then she remains quiet and either walks away or keeps a distance. This will often shock the man into listening or trying to problem solve. Even better, she could step out of the home for a short walk or do something nice for herself like go for a swim.
"But if she is in his face, shouting at him about what's wrong in her life, blaming him, accusing him, and lecturing him – using masculine energy – he will back off even more. If she embarks upon long explanations, he will zone out."
Both Julie and Lesley agree that to get romance back into your life, you need to work on yourself.
"All men love a woman who is confident and self-assured," says Lesley. "They lose interest when a woman becomes needy. Women can look at ways of increasing their confidence. I advise them to go to evening classes, get out more and not to be constantly available.
"Make yourself into a prize by taking care of yourself. Get out there with your head help high and make him come to you.
"Using positive reinforcement is the best way to get what we want and far more effective than plain old nagging. Instead of saying, 'You never bring me flowers', or 'You're not very attentive', try saying, 'I really like it when you bring me roses', or 'I love it when you really listen to me.'"
Dealing with distance
But what if there is no common ground and over the years, you really have put quite an emotional distance between you?
Julie recommends a shine and sparkle evening, where the man makes a shine board and his partner designs a sparkle board. These are vision boards where couples paste pictures and words that sum up their loves, hopes and desires. This is one of the fastest ways to connect and discover each other's passions.
"Look through magazines together," says Julie, "and cut out pictures of things you love or words that catch your attention, and then stick them onto a board. Look at the things your partner has chosen and talk about them.
"You may also discover things about yourself. You may find you really sparkle when you're running or that you're in your element walking your dog. Connecting with yourself is vital so go to workshops, read self-development books and focus on what you love – by doing that you will be making yourself much more attractive."
Add fun to your relationship
- Spend an evening looking at your sparkle and shine boards and talk through each of the pictures or words you put on there, says Julie. "It may be that your partner has always fancied taking up running and he may have cut out a photograph of a man competing in marathons. Encourage him to take up running."
- When you feel anxious about your relationship, take a step back and simply breathe. Getting some good oxygen into your body calms you and when you're less anxious, you'll see things differently. Solutions will pop into your mind when you're relaxed, says Julie.
- Play the 'favourites game', says coach Fiona Sutherland. Take turns naming a favourite movie, restaurant, party, book, adventure or musical instrument. It not only helps you feel good and recall happy memories, it helps you both connect to your values.
- Have a night somewhere different – camp in your garden and pretend you're in the mountains, or go to a hotel and pretend to be aristocrats.
- Change things in your environment. Move furniture around, add some fresh flowers, or burn some candles
Re-ignite romance with tips on positive thinking
1. Work out what you want from your partner. We get what we think about, so when we say we don't want a cruel man, we're likely to get one because that's what we're thinking about. When we think about a kind, considerate person, we're far more likely to attract one.
2. Change the way you speak to your partner. Men, especially, need the difference between a command and a statement to be spelt out. A wishy washy "Can you tidy the kitchen?" leaves a man thinking that he can, but he won't until he can be bothered. Ask him to do the washing up within a certain timescale – for example, before he settles down to watch TV – and he probably will.
3. Look in a mirror and imagine yourself in a room of strangers and give yourself a mark out of ten. Next, think of someone you find attractive and step into her body. Picture yourself in the room this person and give yourself a new mark – it will be higher now you have borrowed some confidence! Information courtesy of neurolinguistic programming expert Matt Hudson, author of The Saboteur Within.
Visit www.thesaboteurwithin.com
Inside Info
Who Are The Flowers In Your Garden? By Julie New is available from Amazon
For more information about Lesley Broadhead's work, visit
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Sky Sources understand West Brom have made a bid for Birmingham defender Liam Ridgewell.
The 27-year-old wanted to quit the Championship club during the summer window, but saw a transfer request rejected before the August deadline.
Last week, Birmingham City manager Chris Hughton insisted the club have yet to receive any enquiries for Ridgewell following reports he is set to leave St Andrew's.
But is now appears West Brom have launched a bid to take the defender to The Hawthorns.
The 27-year-old has previously been linked with the likes of Everton, Queens Park Rangers and Newcastle United following Blues' relegation to the Championship.


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Diode-pumped laser properties of Nd3+-doped La2CaB10O19 crystal including two-frequency generation with 4.6 THz separation
Optics Express, Vol. 17, Issue 21, pp. 18730-18737 (2009)
Enhanced HTML Acrobat PDF (291 KB)
We have studied under laser diode pumping near 800 nm the continuous wave laser operation of the Nd3+ -doped La2CaB10O19 biaxial noncentrosymmetric crystal. From Z-oriented samples we have obtained lasing at 1051.4 nm of Nd3+ ions located in the regular La3+ sites. Self-frequency doubling was obtained with samples oriented at the phase matching direction of the type I ee-o nonlinear interaction. With X-oriented samples, thanks to the existence of two La3+ and Ca2+-sites for the Nd3+ location, we have obtained a two-frequency laser working in dual polarization with a frequency difference unusually large of 4.6 THz.
OCIS Codes
(140.0140) Lasers and laser optics : Lasers and laser optics
(140.3480) Lasers and laser optics : Lasers, diode-pumped
ToC Category:
Lasers and Laser Optics
Original Manuscript: July 22, 2009
Revised Manuscript: September 1, 2009
Manuscript Accepted: September 2, 2009
Published: October 2, 2009
A. Brenier, Yicheng Wu, Peizhen Fu, Jianxiu Zhang, and Yanlei Zu, "Diode-pumped laser properties of Nd3+-doped La2CaB10O19 crystal including two-frequency generation with 4.6 THz separation," Opt. Express 17, 18730-18737 (2009)
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- S. Zhang and T. Bosch, "Orthogonally polarized lasers and their applications," Opt. Photon. News 18. (5), 38 (2007). [CrossRef]
- M. Koch, "Terahertz technology: a land to be discovered," Opt. Photon. News 18 (3), 20 (2007). [CrossRef]
- I. Duling and D. Zimdars, "Compact TD-THz systems offer flexible, turnkey imaging solutions," Laser Focus World 43. (4), 63 (2007).
- M. Tani, P. Gu, M. Hyodo, K. Sakai, and T. Hidaka, "Generation of coherent terahertz radiation by photomixing of dual-mode lasers," Opt. Quantum Electron. 32(4/5), 503–520 (2000). [CrossRef]
- K. Sakai, Terahertz Optoelectronics, (Springer-Verlag Berlin Heidelberg, 2005).
- T. Tanabe, K. Suto, J.-I. Nishizawa, and T. Sasaki, "Characteristics of terahertz-waves from GaSe crystals," J. Phys. D Appl. Phys. 37(2), 155–158 (2004). [CrossRef]
- Y. J. Ding, "High-power tunable terahertz sources based on parametric processes and applications," IEEE J. Sel. Top. Quantum Electron. 13(3), 705–720 (2007). [CrossRef]
- R. Czarny, M. Alouini, C. Larat, M. Krakowski, and D. Dolfi, "THz-dual-frequency lasers for continuous wave THz generation through photomixing," Electron. Lett. 40. (15), 942–943 (2004). [CrossRef]
- A. Brenier, C. Tu, Z. Zhu, and J. Li, "Dual-polarization and dual-wavelength diode-pumped laser operation from the birefringent Yb3+ -doped GdAl3(BO3)4 nonlinear crystal," Appl. Phys. B 89(2-3), 323–328 (2007). [CrossRef]
- M. Brunel, F. Bretenaker, and A. Le Floch, "Tunable optical microwave source using spatially resolved laser eigenstates," Opt. Lett. 22. (6), 384–386 (1997). [CrossRef] [PubMed]
- M. Brunel, O. Emile, M. Vallet, F. Bretenaker, A. Le Floch, L. Fulbert, J. Marty, B. Ferrand, and E. Molva, "Experimental and theoretical study of monomode vectorial lasers passively Q-switch by a Cr4+: yttrium aluminium garnet absorber," Phys. Rev. A 60(5), 4052–4058 (1999). [CrossRef]
- J. Le Gouët, L. Morvan, M. Alouini, J. Bourderionnet, D. Dolfi, and J.-P. Huignard, "Dual-frequency single-axis laser using a lead lanthanum zirconate tantalate (PLZT) birefringent etalon for millimeter wave generation: beyond the standard limit of tenability," Opt. Lett. 32(9), 1090–1092 (2007). [CrossRef] [PubMed]
- A. Saha, A. Ray, S. Mukhopadhyay, N. Sinha, P. K. Dutta, and P. K. Dutta, "Simultaneous multi-wavelength oscillation of Nd laser around 1.3 mum: A potential source for coherent terahertz generation," Opt. Express 14(11), 4721–4726 (2006). [CrossRef] [PubMed]
- A. Brenier, Y. Wu, P. Fu, R. Guo, and F. Jing, "Evidence of self-frequency doubling from two inequivalent Nd3+ centers in the La2CaB10O19:Nd3+ bi-functional crystal," J. Appl. Phys. 98(12), 123528 (2005). [CrossRef]
- G. Wang, J. Lu, D. Cui, Z. Xu, Y. Wu, P. Fu, X. Guan, and C. Chen, "efficient second harmonic generation in a new nonlinear La2CaB10O19 crystal," Opt. Commun. 209(4-6), 481–484 (2002). [CrossRef]
- F. Jing, P. Fu, Y. Wu, Y. Zu, and X. Wang, "growth and assessment of physical properties of a new nonlinear optical crystal: lanthanum calcium borate," Opt. Mater. 30(12), 1867–1872 (2008). [CrossRef]
- A. Brenier, D. Jaque, and A. Majchrowski, "Bi-functional laser and nonlinear optical crystals," Opt. Mater. 28(4), 310–323 (2006). [CrossRef]
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The inclement weather that has covered almost the entire state of North Carolina has caused the North Carolina High School Athletic Association to make adjustments in both the schedule for the
The son of former Georgia Southern University and Chicago Bears running back Adrian Peterson, A.J
That's been the story all week concerning the Northwestern 3A-4A Conference Basketball Tournament. For the third consecutive day, inclement weather has put the tournament on hold. And
Ice and snow across the state Monday coupled with expected extreme temperatures and additional precipitation will prevent the North Carolina baseball team from hosting
Charles Scott of North Carolina, Kansas State's Rolando Blackman, Quinn Buckner of Indiana, Ohio State's John Havlicek and Long Beach State's Ed Ratleff headline the
Four North Carolina men's soccer players, including MAC Hermann Trophy finalist Andy Craven, were named to the 2014 All-ACC Academic Team on Tuesday, as
Ashe County High Athletic Director Marc Payne, based on the information that he received on Tuesday from Wilkes County, Yadkin County, and Elkin (those schools will
Lenoir-Rhyne Moves Up Times For Home Wednesday DH Against Catawba: Lenoir-Rhyne University has moved up the starting times for its home men's and
For the second straight day, the Avery High girls' basketball team had its game with Black Mountain-Owen postponed due to inclement weather. They will attempt to
For the second straight day inclement weather has forced the Northwestern 3A-4A Conference to put it boys' and girls' basketball tournaments on hold. And for the second straight day, the NW3A-4A has been forced to reschedule. For now, the tournament, weather-permitting, will be played on Wednesday. But there is an 80% chance of
The Club Synergy 12-and-Under Blue volleyball team competed in the Capitol Hill Classic this past weekend in Washington D.C. The team and their families joined over 35,000 others from around the country at this national qualifier event. Teams ranging in age from 12-and-under to the nation's elite 18 year olds, both boys and girls, competed on 119 courts. The event also provided recruiting opportunities by drawing coaches from 150 colleges and universities from across the nation.
The Lenoir-Rhyne women's basketball team will host its annual Play 4Kay event on Saturday, February 21. The event will be held in conjunction with the Bears' South
Fresh of its best start in 19 years, the Lenoir-Rhyne Baseball Team (10-0, 3-0) is ranked No. 16 in this week's Collegiate Baseball NCAA Division II National Poll. The
The University of North Carolina has announced several home game designations for the 2015 football season, including Homecoming on Nov. 7 vs. Duke. The other
Tuesday's baseball game between Appalachian State and Campbell, slated to be played in Asheboro, N.C., has been postponed due to the wintry weather that is expected
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Conveniently located near schools, parks, shopping, dining and medical facilities. Siena Village is near downtown Phoenix...the Black Canyon Freeway...Christown Mall...restaurants...and we're on the busline!
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Atmos Energy Controlled Natural Gas Flaring March 8
Atmos Energy crews and contractors will oversee a controlled natural gas flaring on March 8, 2015, beginning at approximately 8:00 AM at the northwest corner of the intersection of Sandy Lake Rd. and N. Coppell Rd. The company will be replacing a section of natural gas pipeline in the area as part of normal, routine maintenance operations."Flaring" is a standard industry practice to safely burn natural gas that must be removed from a specific section of pipeline so that employees can work on the pipe. People in the area will notice a large, controlled flame and moderate noise for approximately three to four hours.The Coppell fire department, sheriff department, police department, city officials and 911 operators have been advised of the flaring.About Atmos EnergyAtmos Energy Corporation, headquartered in Dallas, is one of the country's largest natural-gas-only distributors, serving more than 3 million natural-gas distribution customers in some 1,400 communities in eight states from the Blue Ridge Mountains in the East to the Rocky Mountains in the West. Atmos Energy manages company-owned natural gas pipeline and storage assets, including one of the largest intrastate natural gas pipeline systems in Texas and provides natural gas marketing and procurement services to industrial, commercial and municipal customers primarily in the Midwest and Southeast. For more information, visit www.atmosenergy.com. -
Coppell Farmers Market Next Winter Market Day - March 14
The Coppell Farmers Market winter market dates continue on Mar. 14. Don't miss the bounty available during the winter markets offering fresh kale, collards, and other seasonal produce.
Read more... -
Trail Stabilization and Pedestrian Bridge
Project to Begin in MarchIn February 2015, the Coppell City Council awarded a construction contract for Andy Brown East Erosion/Trail Stabilization and Levee Pedestrian Bridge project, to Core Construction. The project consists of the installation of sea walls and trail stabilization around the lake edge for the lake located on the East side of Moore Road Park.Read more... -
Jeans & Jewels Casino Night at the Coppell Senior and Community Center
Dust off your rhinestones and cowboy boots and try your hand at all your favorite games: Blackjack, Texas Hold 'em, Craps and more! Don't miss out on "Jeans and Jewels" Casino Night at the Coppell Senior Center!Read more...Plaza Music Series Returns this March!
Gather your family and friends, picnic baskets and chairs and join us for a concert in the Plaza! The City of Coppell is pleased to announce the lineup of Plaza music this Spring, featuring popular Beatles tribute band, Me & My Monkey, and 4ever Young and the Reflections, covering oldies rock 'n' roll favorites!Read more...Hazardous Weather Update - Posted 2:00 PM on 03 05 2015
Garbage Collection
Due to hazardous road conditions, Thursday Republic Services collection will shift to Friday. Please have your trash out by 7 AM at your regular collection point.Read more...Public Workshop on Bicycle and Pedestrian Master Plan
The City of Coppell is seeking input regarding the Bicycle and Pedestrian Master Plan. A public workshop was held Wed., Feb. 11 at Town Center where about 90 people showed and provided valuable input. For those who missed the meeting, another opportunity to provide input is available via an online survey.Read more...2nd Annual Coppell/Grapevine Police Motorcycle Competition
The Coppell Police Department is proud to announce the 2nd Annual Coppell/Grapevine Police Motorcycle Competition (a continuance of the Coppell Rodeo established in 2009) to be held March 12 – 14, 2015. This is a training and competition event for police motor officers from around the state and nation. A full schedule of events can be found on their website at www.cgpolicemotorrodeo.com.Read more...
Coppell Fire Department Reminds Citizens To Change Your Battery on March 8As most Americans set their clocks forward one hour, the Coppell Fire Department wants homeowners to "change your clocks and change your batteries" on Sunday, March 8. "Fresh batteries in smoke alarms and carbon monoxide detectors can help provide the extra seconds needed to save a life," Coppell Fire Chief Kevin Richardson states.Read more...City of Coppell Blood Drive - March 17
Did you know that every three seconds a patient in the United States is in need of a blood transfusion? A single donation to a blood drive can save up to 3 lives! You can help make a difference at the City of Coppell Blood Drive.
Read more...
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Join us for a Washington DC Area Alumni Reception. Connect with alumni and learn more about MSU College of Law.
Thursday, March 19, 2015
6:00 to 7:30 p.m.
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Carrie L. Ciliberto, '98
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Are there any really good frap recipes that taste good and work well I like Carmel so i don't if that even helps but would love to hear your ideas!!!
Just blend espresso, ice, caramel-flavored syrup, and whole milk or half'n'half, or light cream in a blender. Experiment with amounts to get the flavor that you like. Here's a recipe that you can use as a blueprint (I would use espresso, not just brewed coffee, since regular coffee would be too dilute when blended),
You can brew a really strong coffee, in place of espresso.
You can make a really strong black coffee by doing what my mother use to do decades before espresso makers were sold, and use the filter basket of any coffee machine. She rested the basket, lined with filter, on top of a coffee mug. Added coffee to basket and poured in the hot water. When the brew had mostly filtered into the mug, she then took that just brewed coffee and poured it back into the basket and let it drip through again. It makes for a rather strong coffee. The important thing is to use a lot of ground coffee, more than you would normally use for a regular American-style coffee. Typically, espresso is 1 Tablespoon ground (fine grind, or espresso grind) coffee per 1 oz water. For a 16oz frappucino, you'll probably need about 2-3 oz of strong black coffee.
Espresso, the real thing, was the product of an engineer in post WWII Italy. In essence it's a strong black coffee thats brewed under high pressure steam. You can come close enough using an inexpensive percolator e.g. the Bialetti. Just stick on top of your gas range. Use an "espresso" grind. Better, grind it yourself.
You can buy espresso powder too. I've never used it to make espresso, but I'm sure you can. You could always buy an espresso shot and then go home and make your latte but that may be counterproductive.
Depending on how particular you are about your coffee, you can go with any of the above suggestions. Either brew very strong coffee. I use 3 coffee scoops per 6 oz glass filled w/ice using a Melitta cone, directly over the ice-filled glass. I pour boiled water over slowly and stir the slurry, to extract the most flavor. If you are not particularly a coffee geek, then just go with Medaglia d'Oro instant espresso powder from the grocery store, make a cup according to package directions, blend in a blender with ice, half and half or milk, some Italian flavoring syrup and you're golden.
OK people. No percolating expresso coffee. This is sacrilege. DO what Pierino says, buy a Bialetti for $45 or so and a grinder for $20 and grind your own coffee beans. Having ground coffee around in an already opened bag for more than a day or two loses aroma and freshness. Buy the beans, keep them in the freezer and use as needed. You will find it to be a more enjoyable and flavorful experience.
@Giovanni50, in most case, I would totally agree with you. But she's make a frappacino. With the dairy, ice, and caramel syrup, I don't think it's really necessary to have the best tasting and freshest coffee. She might be alright with just Folgers ground coffee. Just make sure that it's brewed strong and I think the frappacino would taste just as good as Starbucks.
Giovanni, I agree with you. Coffee geeks don't flavor in their coffee; for them (myself included) it's all about the freshest, perfectly-roasted and best-quality beans from reliable purveyors. But as HalfPint says, if you are drinking a milkshake-like confection, there is little point in sourcing best quality beans only to mask the flavor. I don't think anyone recommended a percolator. Pierino refers to a stove-top moka maker. I was referring to a Hario or Melitta cone.
This discussion brings me back to my Berkeley days, before the invention of the Frappuccino....when I and my cohorts spent all of our spare time at the Caffe Med. So addicted was I to my cappuccino, that as a graduation present from Cal, my generally modest parents presented me a stovetop cappuccino maker, the stainless-steel kind with the gasket, screw on top and dedicated milk-frother. My then-boyfriend, scion of a very well-to-do family, received a Mercedes from his parents. Decades later, my machine is still fully functional; I don't know about his.
Okay...this is not high class. But pretty much good for what you'd get from Starbucks.
Get a french press and make coffee. Let that cool to room temp and put in the 'fridge.
Now, a trip to the store find a product called "Yahoo" chocolate drink and mix that with the coffee...it's not going to win awards but that's basically the bottled StarBucks 'grab and go' thing.
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PD Cars - Used cars in Bristol, Avon
Quality used cars by PD Cars in Bristol...
Piara Singh, the proprietor of P.D.Cars, is a trained motor engineer who has been in the trade for over 30 years. Since PD Cars was established in 1991, it has grown into one of Bristol's most successful specialist used car dealers and service/repair facilities.
"When you purchase a vehicle from our extensive stock at P.D.Cars, you can rest assured that it will be a genuine car that has been thoroughly inspected and put right in every detail. Our in-house staff of motor technicians are VW/Audi specialists and we only use genuine VW parts, as opposed to cheap imitations. If you should find anything not to your satisfaction after you have made a purchase, you can be sure that it will be put right with the requisite level of care and expertise. We sell genuine cars to genuine people - which is one of the reasons why over 65% of our sales are to customers who have purchased from us in the past. Our reputation is your guarantee."
"Not only do we sell top-quality used VWs and Audis at prices that represent excellent value, but we are also able to service and repair them at competitive prices. My experience of over 30 years as a motor engineer on Volvos and subsequently on VW/Audi, is at your service. This background is what enables me to guarantee that any car you buy from PD Cars is a first-class specimen, in excellent condition and a purchase that in the medium-to-long term will represent sound value for money. Also, you can be secure in the knowledge that your car will be serviced and repaired by our specialist technicians using VW diagnostic equipment, and at a fraction of the price at a main dealer. Call us for a quote."
Services We Offer Include:
Car sales, Service and Repairs | MOTs | Dedicated VAG diagnostic facilities | Valeting | Tyres and Wheel Alignment | Air Conditioning Repairs | Bodywork/ Cosmetic Repairs | Servicing done with genuine VAG parts | Expert VW specialist technicians | Large, well-equipped workshop | All work fully guaranteed | Friendly, personal service | Quality workmanship at competitive prices.
Contact Details
PD Cars
221-223 Gloucester Road, BishopstonBristol
Telephone: 0117 908 2225
Mobile: 07831 611887