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Burglar steals World War II medals from Workington house
Last updated at 12:34, Wednesday, 28 November 2012
A burglar has stolen three World War II medals from a house in Workington while the elderly occupant was out.
Police say the medals are of high sentimental value to the victim.
They are appealing for any information which would help return the medals to their owner.
The burglary happened late on Sunday evening in Robinson Street.
Two of the items were silver circular medals and the third was in the shape of a star.
Anyone with information should call DC Tim Carr or anyone at Workington CID on 101 or Crimestoppers on 0800 555111.
First published at 11:26, Wednesday, 28 November 2012
Published by http://www.timesandstar.co.uk
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subset: commoncrawl


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Battlefield 4 (Pre-Order Edition - Day 1) PlayStation3 15 New from £16.21 Free delivery Available used from £9.81
1 FOUL!Posted: 03/11/2013This game is shocking on all levels nothing has changed since bad company! levels are still shocking,shocking graphics,terrible weapons, rubbish gameplay,shocking spawning and takes forever to rank up. Single player lasts about 5 mins. Beware of sniping which is the same point blank range still takes 2 to 3 shots to kill if you miss the head and by this time someone has blown your head off by then. This game is a pile of rubbish and im shocked these people even get funding to make such a pile of stink. RUBBISH DON'T BUY!!!
1 Worst call of duty ever!!!Posted: 11/11/2011Single player is easy and boring! The first thing i noticed about this game was the terrible sound effects, battlefield 3 has the best by the way. Multiplayer is horrendous, graphics are poor, levels are so basic and tiny i feel sorry for people wishing to snipe on this game. Seriously who ever made this terrible game should really sit down and play a few matches then they would realise what a massive pile of manure it actually is. Im so angry and let down having waited forever for this hyped up game to come out and its the worst cod ever made! Honestly what were you thinking, thank you call of duty for making this pile of turd.
Metal Gear Solid 4: Guns Of The Patriots (PS3) PlayStation3 3 New from £16.38 Free delivery Available used from £5.17
5 One of the best...Posted: 27/04/2011After playing mgs 1, 2, 3 this is a incredible end to the solid snake saga. One of the best storylines ever created and some of the best characters aswell. The graphics are unreal and the gameplay is the classic mgs stealth based combat which runs smooth and the different ways to eliminate people proves extremely satisfying. Overall its worth buying a ps3 simply for this game because its the best for this console.
The Elder Scrolls IV: Oblivion (Classic) Xbox 360 1 New from £18.95 Free delivery Available used from £1.37
5 The best game ever madePosted: 11/04/2011Nothing that has been released in my opinion compares to oblivion. For its time its simply unbeleivable the graphics are superb considering the sheer size of cyrodiil and the amount of detail within it. Also the story line is incredible and the ability to completely create your character and become more powerful as the story progresses. Overall if you enjoy RPG's or sword/magic style game this is a must buy as you will be hooked for days on end due to oblivions endless possibilities!
5 SuperbPosted: 11/04/2011For its time this game is very good the story line alone for me gives it a 10/10. The graphics are crisp and clear and the gameplay is very satisfying inlcluding leveling up, capturing new golems and visiting new towns/cities. Also for a change the main characters are actually interesting and each bring different skills to the turn base combat style of fighting. Clearly this style of game wont apeal to everyone but for people who enjoy RPG's or final fantasy style games this is a must have.
Killzone 3 (PlayStation Move Compatible) PlayStation3 8 New from £7.95 Free delivery Available used from £3.72
3 Nothing special!!!Posted: 26/02/2011Just got the game, very decent campaign i must say. I was really looking forward to the mutliplayer which is a bit average i dont know why everyone is raving about this game! the servers are slow and crash all the time. The weapons are ok i guess but nothing really gets you that excited, although i have to admit the knifing is very satisfying!! The levels are a bit annoying and very simple, i have to say i bought this game because it looked great and was so damn bored of playing call of duty games, but in reality its no where near as good as black ops mutliplayer and u all know this really. For me its just another hyped up let down yet again, please somone make a brilliant multiplayer game so i dont have to play black ops because killzone 3 online is just very average!!
Medal Of Honor: Limited Edition (with Battlefield 3 Multiplayer BETA Access) Xbox 360 3 New from £37.36 Free delivery Available used from £3.16
1 SO BAD!Posted: 16/10/2010Shocking graphics, terrible campaign,multiplayer is dreadful, Hardly any weapons, levels are so bad and killstreaks are very poor. Do not buy this game save for black ops this game is just awful!!!
1 shift is a dissapointment.Posted: 20/09/2009i already want to sell this game because it is a total letdown.if you enjoyed undercover which i did,dont buy this game as there is no comparison.the driving is really stiff,unreactive and unrealistic.the game automaticaly brakes for you and every time i turn the feature off it still does it in the race,the graphics have not improved,there is no storyline,not many cars in the game,1 little scrape on the side pebbles spins you out of control and the drifting is awfull.All nfs fans do not buy!its crap.


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Weekend Promo: Deponia 95% off, up to 75% off Tropico, Port Royale, Settlers and more at GOG.
Connecting the GBA at the title screen.
Select how many points you want to aim for.
Good old classic map
Perhaps you're in the mood for something a little more dangerous?
Shadow, Inky, Pinky... and Green(‽) where's Clyde?
Pass the GBA.
Inky as Pac-Man leaves a blue trail.
The hunters become the hunted.
Fruit works wonders for ghost vision, green just ate some cherries.
Pink closes in while green losses the trail.
Shadow makes the catch.
Red won that round. Points are added and subtracted.
Pinky hides in from the insatiable pac-jaws in the only safe refuge.
Pac-Man has cleared the field, the game will continue until someone get the target score.
Red gets the target.
Manic Manor


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Red warning triangle with a broken down car
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text: FIFTH SUNDAY IN ORDINARY TIME FEBRUARY 6, 2011 Worship & Spirituality Fred F. Allen, Chris Ames, Joe Ames, Miranda Bachelder, Richard Bergevin, Nick Caivano, Roland Clukey, Anita WEEKEND SCHEDULE FEBRUARY 5 & 6 Colomy, Jack Costello, Leona Crawford, Jeanie Cyr, Martha Danforth, Patrick DeCesare, Vernette Dechaine, Saturday Eugene DeLorenzo, Brenda Edgerly, Bill Goodman, James 4:00 PM @ St Agnes Mass † Deceased Family & Friends of Gordon, Gail Goulette, Michael Grossi, Eva Hejducek, Richard Savage Marguerite Laflamme, Ed Jacobson, Dave Jennings, 4:00 PM @ St Thomas Mass † John Tucci, Jr. by Miriam Jeanne Jennings, William Jennings, Tracy Kasprzak, McArthur Lynne Kelly, Nancy Kerwin, Gayle Kiernan, Michelle Sunday Fifth Sunday in Ordinary Time LaBree, Barbara Laferriere, Hilda Lankist, Reuben Lumbra, 8:30 AM @ St Agnes Mass † Deceased Family & Friends of Donald Martin Jr, Jim Matthews, Miriam McArthur, James Mr David Welch Morrison, Josephine Morrison, Barbara Munsell, Rose 9:00 AM @ St Thomas Mass For the Intentions of Kaye Libby Nelson, Teresa Page, Ray Paine, Rae-ann Paradis, & Family Catherine Quirion, Honorene Richardson, Angelo Rizzo, 10:30 AM @ St Anne Mass † Marge Handville by Elizabeth Ronco, Vince & Jo Ronco, Timmy Ryan, Timothy Dexter/Dover Ultreya Ryan, Dorothy Sirois, Dwight Sprague, Todd Supka, Dick 11:00 AM @ St Francis/ Mass For the Intentions of Tom & Sylvia, Matthew Troy, Tom Welsh St Paul Terrie Allen by John & Sue Allen & Family 4:00 PM @ St Anne Mass For the People of Our Lady of the Snows Parish Irene Dube, Andre Cadieux WEEKDAY MASSES FEBRUARY 7-11 Weekday Masses Monday 8:30 AM @ St Thomas Mass †Irene Dube by Our Lady of the Snows Parish Tuesday Readings for the week of: February 7th 8:30 AM @ St Anne Mass † Gary Carvalho by the Monday: Gn1:1-19; Mk 6:53-56 Desmarais Family Tuesday: Gn 1:20-2:4a; Mk 7:1-13 Thursday Wednesday: Gn 2:4b-9, 15-17; Mk 7:14-23 5:00 PM @ St Agnes Mass † Deceased Family members Thursday: Gn 2:18-25; Mk 7:24-30 of Mr & MRs John Deetjen, Jr. Friday: Gn 3:1-8; Mk 7:31-37 Friday Saturday: Gn 3:9-24; Mk 8:1-10 8:30 AM @ St Francis/ Mass † Andre Paul Cadieux by Our St Paul Lady of the Snows Parish Sunday: Sir 15:15-20; Mt 5:17-37 WEEKEND SCHEDULE FEBRUARY 12 & 13 In preparation for Mass, open your Bible or logon to United States Saturday Conference of Catholic Bishops 4:00 PM @ St Agnes Mass † Isabelle Sandello by George website www.nccbuscc.org and click & Phyllis Dami on Daily Readings. 4:00 PM @ St Thomas Sunday Celebration Sunday Sixth Sunday in Ordinary Time 8:30 AM @ St Agnes Mass For the People of St Agnes Parish 9:00 AM @ St Thomas Sunday Celebration 10:30 AM @ St Anne Mass † Phillip Jacobson by the Class Next weekend, February 12th of '53 & 13th, Sunday Celebration in 11:00 AM @ St Francis/ Sunday Celebration the Absence of a Priest will be St Paul held at St Thomas and at Sts 4:00 PM @ St Anne Mass † Herman Belanger by Elsie Francis & Paul. Masses will Belanger be held at St Anne and St Agnes. FIFTH SUNDAY IN ORDINARY TIME FEBRUARY 6, 2011 Since the beginning of the year I have made comments about the length of daylight and how we should be optimistic because of its increase. For some people the shortness in daylight has very serious and sometimes almost debilitating effects. As daylight length increases during this time of year there is relief for those so affected. When applied to living our faith this phenomenon can help us understand the positive effect we can have on others all the time. Jesus says to his disciples: "You are the light of the world." The danger we have concerning faith is that when we do not practice it well, when we do not let our "light" shine, the effect can be similar on people as is the lack of daylight. The Beatitudes we heard about last week can be of help as a starting point. Those who let the "light" shine by living the Beatitudes "in spirit" can have a big impact. The daylight length only needs to increase in small increments at first to give benefits. Our faith can have the same impact of encouragement if we live it with the right attitude, even if we practice it in small ways. With my prayers, Father Ouellette Vocations: Activities for this Week Fifth Sunday in Ordinary Time -- February 6, 2011 - Sunday 2/06 SA Religious Ed K-5 9 AM @ PC World Day of Prayer for Consecrated Life STA Religious Ed K-5 10 AM @ CLC STA Jr Youth 10 AM @ STA "Let your light shine before others" perhaps as a priest, Our Lady's Kitchen 12-1 PM @ SA deacon, sister or brother the consecrated life or Monday RCIA 6:30 PM @ STA priesthood. RCIA 7 PM @ SA Fr. Bob Vaillancourt @ 207-773-6471 Tuesday Praying of the Rosary 8:05 AM @ SA firstname.lastname@example.com Building & Grounds Comm. Mtg 5:30 PM or Sr. Rita Mae Bissonnette @ 207-773-6471 @ SA firstname.lastname@example.com Finance Council meeting 6:30 PM @ SA SA Choir 6:30 PM @ SA Social Justice & Peace Mtg 6:30 PM @ STA Wednesday Communion Svc 8:30 AM @ SA Matthew 25 3 PM @ MVYDC FOOD COLLECTION Thursday Praying of the Rosary 8:05 AM @ SA The item for next week is: Communion Service 8:30 AM @ SA Canned beans or vegetables Alzheimer's Support 1:30 PM @ SA STA K of C 7 PM @ STA Saturday Valentine Social 6:30 PM at Mansion Event Food Collection at all sites is taken to Center, Dexter local food cupboards Sunday 2/13 SA Religious Ed K-5 9 AM @ PC Thank you for your donations. STA Religious Ed K-5 10 AM @ CLC STA Jr Youth 10 AM @ STA Our Lady's Kitchen 12-1 PM @ SA God Squad 5:30 PM @ STA Blessed are those who mourn; for they shall be comforted. Our Cluster is implementing a new ministry. Quite often we receive notice Due to the winter weather, the offertory of a funeral after the bulletin has been will be posted next week. published. Our bereavement team members are wonderful however there are others within our cluster who may want to offer comfort as well. If you would like to receive notification of funerals within our cluster, please send your email address to the office, firstname.lastname@example.com Meeting Moved due to weather The Finance Council/Building & Maintenance meeting will now take place on February 8th FIFTH SUNDAY IN ORDINARY TIME FEBRUARY 6, 2011 Faith Formation Reflection of the Week Winter brings us a time Last chance for the February Family Fun Basket! of shorter, darker, colder days. However This is a family fun basket designed to take it also brings us fresh advantage of some outdoor activities but fallen snow that also the warm cozy ones that this sparkles and plenty of season provides for us. It includes: outdoor activities. 2 flying saucer sleds, handmade While we are enjoying mittens, socks and scarves. A the beauty that God shares with us during winter please take a knitted afghan, cocoa mixes, mini moment to reflect on His word. It just might make the days a marshmallows, mugs for warm little brighter and warmer. drinks, a bundle of kindling for keeping warm and other fun activities for your family pleasure. As always the raffle is to benefit our youth going to Spain. The tickets are $1.00 each or 6 for $5.00, and Fifth Sunday in Ordinary Time, Year A must be received in the office no later than (You are Salt of the Earth) February 9th February 6, 2011 First Reading: Isaiah 58:7-10 (Shine in Darkness) Second Reading: 1 Corinthians 2:1-5 (Proclaim the Do you use Scentsy? If so, please consider Good News) placing your next order with Kim Wick. 100% Gospel: Matthew 5:13-16 (Light of the World) of the proceeds will go to the Youth travelling to Spain. Haven't heard of Scentsy? It is a safe wickless alternative to scented candles. Adult: For more information visit https://kimberlywick.scentsy.us When Jesus tells me that I am salt and light in this world, what new thing do I Everyone is welcome to the Life Teen Mass understand about myself and on the 4th Sunday of each month at 4 PM at my fellow believers? St Anne in Dexter. Children: How can I bring the light of Jesus to my family and my friends? Pizza with our Priest All Junior & Senior Youth are invited to have pizza with Fr Ouellette on the 4th Sunday of each month following the 4 PM Youth Mass Scout Sunday February 6th at St Anne in Dexter. Please join us at the 4 PM Mass at St Anne on February 6th to celebrate Scout Sunday, followed by a dessert reception. All are welcome to attend There is no God Squad meeting this week. We will meet next Sunday at the CLC in Dover at 5:30 PM. All High School Teens are encouraged to come. BOTTLE & CAN DRIVE The Youth of Our Lady of the Snows & St Agnes Parishes will be at each worship site next weekend to collect your bottles & cans. All proceeds from the collection will help defer the cost of the trip to Spain for World Youth Day 2011. FIFTH SUNDAY IN ORDINARY TIME FEBRUARY 6, 2011 Social Justice & Peace Confessions will be heard ½ hour before any Mass at which the pastor will be present There will be a Lenten, Holy Week, and Easter planning meeting held at St. Anne's Parish …for I was hungry and you gave me food, I was thirsty and Hall on Thursday, February 10th at you gave me something to drink, I was a stranger and you 6:30 PM. Scheduling of services, welcomed me... (Matt 25:35) special events, music and environment will be discussed. A hot meal will be offered between 12 and 1 PM at Anyone involved or who would like St. Anne's Parish Hall to be involved in any of those 60 Free Street in Dexter every Sunday. A great way to get out of the house and share a areas is encouraged to attend. meal with others. All are welcome. Thank you Team 5 for your donation of time, energy, and talents. You are instrumental in keeping our ministry March Bingo is coming! strong as we take seriously our Lord's challenge to feed We need help with prizes, food, setting up, the hungry, comfort the lonely and welcome them with serving and cleaning up. If you can help us in open arms to God's table. You are a wonderful group of anyway please sign up at the back of the people and we appreciate all you do! church or call Lynn Lubas at 564-3981, Rheba Have a great week and join Our Lady's Kitchen again next Michaud at 564-7494 or Rachel Hersey at 924- Sunday - same time, same place! 7936. This year's Bingo will benefit our youth heading to Spain for World Youth Day. Please watch the bulletin for more information. Prayer to the Blessed Mother Mary We humbly pray to you to ask for your intercession, for the hungry that they be fed, for the lonely that they be comforted, for the depressed that they be enlightened, for Knights of Columbus the stressed that they be relieved, for the turned away that they be returned, for the faithful that they be aware, for Our Cardinal Mercier Assembly #365, 4th Lady's Kitchen to supply the bread of life to all Degree Knights of Columbus, will hold a Amen business meeting on Thursday, February 17th, at 7 P.M., at the K of C Home in Dexter. All members are urged to attend. Let us all pray for peace. Divorce is painful and shattering! Please keep our service Don't go through it alone. women and You can find hope and healing in a "Divorce & men in your prayers. Beyond" group. Our 8 week, facilitated groups are a caring and compassionate place where you can share thoughts and feelings with others who are also experiencing the loss of a marriage. A new group starts Tuesday night, March 1st, from 6:30 to 8:30 p.m. in Bangor. For location information & to register, 1-800-781- 8550, ext. 2672. E-mail: email@example.com. Pre-registration is required. Fee is $25.00.


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What does GLWO mean in Internet?
This page is about the meanings of the acronym/abbreviation/shorthand GLWO in the field in general and in the Internet terminology in particular.
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Heisman Watch: Why Michigan State Should Fear Ameer Abdullah Of Nebraska
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CFB Spotlight: October Will Get Started With A Bang
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What You Need To Know About The College Football Playoff
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Heisman Watch: Jameis Winston's Repeat Bid Against History
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College Football Spotlight: Conference Perception Key As Big 12 Makes Statement
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Huskies Rout Illini, 44-19
Linebacker Shaq Thompson returned an interception 36 yards for a touchdown, picked up a fumble and rumbled 52 yards for another score, and Washington routed Illinois 44-19 on Saturday, improving to 3-0 under Chris Petersen.
College Football Spotlight: Battered Big Ten Is Beleaguered, But Not Beaten Just Yet
Unfortunately for the Big Ten, the chance to prove itself on the national stage in 2014 has officially been missed.
NCAA Lifts Penn State's Postseason Ban
The Nittany Lions were halfway through a four-year postseason ban stemming from the Jerry Sandusky scandal.
Notre Dame Says Goodbye To Michigan With Shutout
Everett Golson threw three touchdown passes and No. 16 Notre Dame said so long to Michigan on Saturday night with a 31-0 victory, the Fighting Irish's most dominant performance in the historic rivalry that's now about to take a hiatus.
Baffoe: End Of Notre Dame-Michigan Rivalry A Perfect NCAA Metaphor
Saturday's game is the last on the docket between the Wolverines and Irish.
Heisman Watch: Kenny Hill Thrilled But It Is A Long Season
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Lanterns for Life to light up Lake Okabena
WORTHINGTON — Established in 2012 by an Adrian couple, Cancer Doesn't Discriminate will host its second annual Lanterns for Life fundraiser Saturday evening at Centennial Park in Worthington.
Lanterns for Life is one of two fundraisers the organization hosts each year. The other is a motorcycle run in early June, marking Regan Roloff's June 2011 diagnosis of stomach cancer.
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Publications (108)467.26 Total impact
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ABSTRACT: Background:Eribulin mesylate is a synthetic macrocyclic ketone analogue of Halichondrin B that has demonstrated high antitumor activity in preclinical and clinical settings. This phase I study aimed to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetics in combination with cisplatin (CP) in patients with advanced solid tumours.Methods:Thirty-six patients with advanced solid tumours received eribulin mesylate 0.7-1.4 mg m(-2) and CP 60-75 mg m(-2). Eribulin mesylate was administered on days 1, 8, and 15 in combination with CP day 1 every 28-day cycle. The protocol was amended after dose level 4 (eribulin mesylate 1.4 mg m(-2), CP 60 mg m(-2)) when it was not feasible to administer eribulin mesylate on day 15 because of neutropenia; the treatment schedule was changed to eribulin mesylate on days 1 and 8 and CP on day 1 every 21 days.Results:On the 28-day schedule, three patients had DLT during the first cycle: grade (G) 4 febrile neutropenia (1.0 mg m(-2), 60 mg m(-2)); G 3 anorexia/fatigue/hypokalemia (1.2 mg m(-2), 60 mg m(-2)); and G 3 stomatitis/nausea/vomiting/fatigue (1.4 mg m(-2), 60 mg m(-2)). On the 21-day schedule, three patients had DLT during the first cycle: G 3 hypokalemia/hyponatremia (1.4 mg m(-2), 60 mg m(-2)); G 4 mucositis (1.4 mg m(-2), 60 mg m(-2)); and G 3 hypokalemia (1.2 mg m(-2), 75 mg m(-2)). The MTD and recommended phase II dose was determined as eribulin mesylate 1.2 mg m(-2) (days 1, 8) and CP 75 mg m(-2) (day 1), on a 21-day cycle. Two patients had unconfirmed partial responses (PR) (pancreatic and breast cancers) and two had PR (oesophageal and bladder cancers).Conclusions:On the 21-day cycle, eribulin mesylate 1.2 mg m(-2), administered on days 1 and 8, in combination with CP 75 mg m(-2), administered on day 1 is well tolerated and showed preliminary anticancer activity.British Journal of Cancer advance online publication, 28 October 2014; doi:10.1038/bjc.2014.554 www.bjcancer.com.British Journal of Cancer 10/2014; · 4.82 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: IMPORTANCE Radiation therapy to the head and neck has traditionally been associated with adverse effects that can affect oral health and physical functioning. Although intensity-modulated radiotherapy (IMRT) has been widely adopted as a means of decreasing toxic effects, limited clinical data exist on its potential effect on long-term quality of life. OBJECTIVE To analyze quality of life among long-term survivors of head and neck cancer treated with IMRT. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional analysis studied 50 consecutive long-term survivors of head and neck cancer from a comprehensive cancer center who had previously undergone IMRT that required bilateral neck irradiation for locally advanced disease. All patients were clinically without evidence of recurrent disease and had at least 5 years of follow-up. MAIN OUTCOMES AND MEASURES The University of Washington Quality of Life (UW-QOL) scores were reviewed for all study participants. The UW-QOL questionnaire consists of 12 domains that pertain to the degree of quality of life in the categories of pain, appearance, activity, recreation, swallowing, chewing, speech, shoulder function, taste, saliva, mood, and anxiety. RESULTS Five years after completion of IMRT, 42 patients (84%) reported that their health-related quality of life was "much better" or "somewhat better" than at the time of cancer diagnosis. With respect to recent health-related quality of life during the preceding 7 days at the time of completing the UW-QOL questionnaire, 40 patients (80%) treated with IMRT reported "outstanding" or "very good" levels of functioning. Five years after completion of treatment, 41 (82%) rated their overall quality of life as "outstanding" or "very good." The lowest domain score on the UW-QOL questionnaire at 5 years pertained to salivary dysfunction. However, 42 patients (84%) reported saliva "of normal consistency" or "less saliva than normal but enough" compared with 8 (16%) reporting "too little saliva." No patient reported having "no saliva." CONCLUSIONS AND RELEVANCE Our findings add to the body of literature that supports the acceptance of IMRT as standard treatment for head and neck cancer. The fact that most 5-year survivors were satisfied with their quality of lives points to the ability of IMRT to preserve long-term functioning.JAMA otolaryngology-- head & neck surgery. 12/2013; - [Show abstract] [Hide abstract]
ABSTRACT: Background Despite advances in targeted therapies, there is an ongoing need to develop new and effective cytotoxic drug combinations in non-small cell lung cancer (NSCLC). Based on preclinical demonstration of additive cytotoxicity, we evaluated the safety and efficacy of combining pemetrexed and nanoparticle albumin bound (nab) paclitaxel with a focus on NSCLC for phase II expansion. Methods A 3 + 3 dose-escalation design was used to determine the maximum tolerated dose (MTD) and the recommended phase II dose (RP2D). Three dose levels were tested: pemetrexed 500 mg/m(2) day 1 and nab-paclitaxel day 1 at 180, 220, & 260 mg/m(2) every 21 days. Phase II eligibility included advanced NSCLC, ≤2 line prior therapy, PS 0-1, adequate organ function. Primary endpoint for further study was response rate (RR) ≥ 25 %. Results Planned dose escalation was completed without reaching the MTD. The RP2D was pemetrexed 500 mg/m(2) and nab-paclitaxel 260 mg/m(2). The phase II portion accrued 37 pts before early closure due to increasing first-line pemetrexed/platinum doublet use in non-squamous NSCLC. In 31 assessable phase II patients there were 5 partial responses, 12 stable disease, 14 progressive disease. The median overall survival was 8.8 months; progressive disease 4.4 months and disease control 15.6 months. Conclusions Pemetrexed 500 mg/m(2) day 1 with nab-paclitaxel 260 mg/m(2) was feasible and well tolerated. The phase II component demonstrated activity in second/third-line therapy of advanced NSCLC; response rate 14 % and disease control rate 46 %. Treatment practice patterns of advanced NSCLC have evolved; further trials of this regimen are not planned.Investigational New Drugs 09/2013; 31(6). · 3.50 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Although concurrrent chemoradiation is increasingly used for patients with locally advanced head and neck cancer, many elderly patients receive radiation alone due to toxicity concerns. We evaluate acute and late toxicity among patients age ≥65 who received concurrent chemoradiation for head and neck cancer. Retrospective review. Tertiary care center. Between 6/2003 and 8/2011, 40 consecutive patients age ≥65 underwent combined chemoradiation for head and neck cancer. Ten patients were treated in the postoperative setting and 30 underwent definitive chemoradiation. Twenty-eight patients received concurrent platinum-based chemotherapy and 12 received concurrent weekly paclitaxel. Treatment plans were designed to provide a dose of 66-72Gy at 2-2.12Gy/fraction to >95% of the gross tumor volume in the definitive setting or for positive margins and 60-66Gy at 2Gy/fraction post-operatively. Median follow-up was 23.2months (range: 0-94.4months). Acute skin and mucosal toxicity, unplanned treatment interruptions, and chronic treatment related toxicity including gastrostomy tube dependence as graded by the CTCAE v3.0. Eight patients (20%) required a radiation treatment break of ≥3days. Thirteen (33%) required unplanned hospitalization during or immediately following treatment. No grade 4+ skin or mucosal toxicity was noted. Five patients remained PEG tube dependent at >1year. One patient developed non-healing mandibular osteoradionecrosis >3years following chemoradiation. The 2-year Kaplan-Meier estimate of overall survival was 55%. Higher-than-expected rates of in-patient hospitalization with significant acute toxicity were noted in this cohort with a correspondingly high rate of radiation treatment breaks. Late toxicity rates were similar to those observed in historical controls with younger patients. Careful patient selection criteria should be employed for elderly patients considering concurrent chemoradiation for head and neck cancer.American journal of otolaryngology 08/2013; · 1.08 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Pemetrexed, a multitargeted antifolate drug, is an active agent in non-small-cell lung cancer (NSCLC), especially adenocarcinomas. Based on preclinical data supporting the relevance of alpha-folate receptors in adenocarcinoma of the bronchioloalveolar carcinoma (BAC) subtype, this trial was designed to assess pemetrexed in patients with this pathologic subtype of lung adenocarcinoma. PATIENTS AND METHODS: Patients with histologically confirmed stage IIIB (with malignant pleural effusion) or stage IV adenocarcinoma with BAC features or pure BAC were eligible. Treatment consisted of pemetrexed, 500 mg/m(2), administered intravenously every 21 days. RESULTS: Of 27 patients enrolled, 24 were eligible and assessable for adverse events: Toxicity was primarily hematologic, consisting of leukopenia/neutropenia, thrombocytopenia, and anemia. The median follow-up among patients still alive (n = 8) was 35 months (range, 26-47 months). Among 17 patients with measurable disease, the response rate was 23% (all partial responses; 95% confidence interval [CI], 10%-56%). The median progression-free survival (PFS) and overall survival (OS) were 6 and 25 months, respectively. CONCLUSION: Pemetrexed is active and well tolerated and, in patients with adenocarcinoma BAC subtypes, likely related to its underlying mechanism of action as a multitargeted antifolate drug.Clinical Lung Cancer 02/2013; · 2.04 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Purpose: Stage III non-small cell lung cancer (NSCLC) patients with poor performance status (PS) or co-morbidities are often not candidates for standard chemoradiotherapy (chemoRT) due to poor tolerance to treatments. A pilot study for poor-risk stage III NSCLC patients was conducted combining cetuximab, a chimeric monoclonal antibody targeting epidermal growth factor receptor (EGFR), with chest radiation (RT). Methods: Stage III NSCLC patients with Zubrod PS 2, or Zubrod PS 0-1 with poor pulmonary function and co-morbidities prohibiting chemoRT were eligible. A loading dose of cetuximab (400 mg/m(2)) was delivered week 1, followed by weekly cetuximab (250 mg/m(2))/RT to 64.8 Gy in 1.8 Gy daily fractions, and maintenance weekly cetuximab (250 mg/m(2)) for 2 years or until disease progression. H-score for EGFR protein expression was conducted in available tumors. Results: Twenty-four patients were enrolled. Twenty-two were assessed for outcome and toxicity. Median survival was 14 months and median progression-free survival was 8 months. The response rate was 47% and disease control rate was 74%. Toxicity assessment revealed 22.7% overall ≥Grade 3 non-hematologic toxicities. Grade 3 esophagitis was observed in one patient (5%). The skin reactions were mostly Grade 1 or 2 except two of 22 (9%) had Grade 3 acne and one of 22 (5%) had Grade 3 radiation skin burn. Grade 3-4 hypomagnesemia was seen in four (18%) patients. One patient (5%) had elevated cardiac troponin and pulmonary emboli. H-score did not reveal prognostic significance. An initially planned second cohort of the study did not commence due to slow accrual, which would have added weekly docetaxel to cetuximab/RT after completion of the first cohort of patients. Conclusion: Concurrent weekly cetuximab/chest RT followed by maintenance cetuximab for poor-risk stage III NSCLC was well tolerated. Further studies with larger sample sizes will be useful to establish the optimal therapeutic ratio of this regimen.Frontiers in Oncology 01/2013; 3:219. - [Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVES/HYPOTHESIS: To evaluate the responsiveness of human papillomavirus (HPV) -positive and HPV-negative oropharyngeal cancer to intensity-modulated radiotherapy (IMRT), using axial imaging obtained daily during the course of image-guided radiotherapy (IGRT). STUDY DESIGN: Observational cohort study with matched-pair analysis of patients irradiated for HPV-positive and HPV-negative oropharygeal cancer. METHODS AND MATERIALS: Ten patients treated by IMRT to 70 Gy for locally advanced, HPV-positive squamous cell carcinoma of the oropharynx were matched to one HPV-negative control subject by age, gender, performance status, T-category, tumor location, and the use of concurrent chemotherapy. The gross tumor volume (GTV) was delineated on daily IGRT scans obtained via kilovoltage cone-beam computed tomography (CBCT). Mathematical modeling using fitted mixed-effects repeated measure analysis was performed to quantitatively and descriptively assess the trajectory of tumor regression. RESULTS: Patients with HPV-positive tumors experienced a more rapid rate of tumor regression between day 1 of IMRT and the beginning of week 2 (-33% Δ GTV) compared to their counterparts with HPV-negative tumors (-10% Δ GTV), which was statistically significant (p<0.001). During this initial period, the average absolute change in GTV was -22.9 cc/week for HPV-positive tumors and -5.9 cc/week for HPV-negative tumors (p<0.001). After week 2 of IMRT, the rates of GTV regression were comparable between the two groups. CONCLUSIONS: HPV-positive oropharyngeal cancers exhibited an enhanced response to radiation, characterized by a dramatically more rapid initial regression than those with HPV-negative tumors. Implications for treatment de-intensification in the context of future clinical trials and the possible mechanisms underlying this increased radiosensitivity will be discussed.The Laryngoscope 09/2012; · 2.03 Impact Factor -
Article: Brachial plexus-associated neuropathy after high-dose radiation therapy for head-and-neck cancer.
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ABSTRACT: To identify clinical and treatment-related predictors of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer. Three hundred thirty patients who had previously completed radiation therapy for head-and-neck cancer were prospectively screened using a standardized instrument for symptoms of neuropathy thought to be related to brachial plexus injury. All patients were disease-free at the time of screening. The median time from completion of radiation therapy was 56 months (range, 6-135 months). One-hundred fifty-five patients (47%) were treated by definitive radiation therapy, and 175 (53%) were treated postoperatively. Radiation doses ranged from 50 to 74 Gy (median, 66 Gy). Intensity-modulated radiation therapy was used in 62% of cases, and 133 patients (40%) received concurrent chemotherapy. Forty patients (12%) reported neuropathic symptoms, with the most common being ipsilateral pain (50%), numbness/tingling (40%), motor weakness, and/or muscle atrophy (25%). When patients with <5 years of follow-up were excluded, the rate of positive symptoms increased to 22%. On univariate analysis, the following factors were significantly associated with brachial plexus symptoms: prior neck dissection (p = 0.01), concurrent chemotherapy (p = 0.01), and radiation maximum dose (p < 0.001). Cox regression analysis confirmed that both neck dissection (p < 0.001) and radiation maximum dose (p < 0.001) were independently predictive of symptoms. The incidence of brachial plexus-associated neuropathies after radiation therapy for head-and-neck cancer may be underreported. In view of the dose-response relationship identified, limiting radiation dose to the brachial plexus should be considered when possible.International journal of radiation oncology, biology, physics 03/2012; 84(1):165-9. · 4.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To compare the long-term quality of life among patients treated with and without intensity-modulated radiotherapy (IMRT) for head-and-neck cancer. The University of Washington Quality of Life instrument scores were reviewed for 155 patients previously treated with radiation therapy for locally advanced head-and-neck cancer. All patients were disease free and had at least 2 years of follow-up. Eighty-four patients (54%) were treated with IMRT. The remaining 71 patients (46%) were treated with three-dimensional conformal radiotherapy (3D CRT) by use of initial opposed lateral fields matched to a low anterior neck field. The mean global quality of life scores were 67.5 and 80.1 for the IMRT patients at 1 and 2 years, respectively, compared with 55.4 and 57.0 for the 3D CRT patients, respectively (p < 0.001). At 1 year after the completion of radiation therapy, the proportion of patients who rated their global quality of life as "very good" or "outstanding" was 51% and 41% among patients treated by IMRT and 3DCRT, respectively (p = 0.11). At 2 years, the corresponding percentages increased to 73% and 49%, respectively (p < 0.001). On multivariate analysis accounting for sex, age, radiation intent (definitive vs. postoperative), radiation dose, T stage, primary site, use of concurrent chemotherapy, and neck dissection, the use of IMRT was the only variable independently associated with improved quality of life (p = 0.01). The early quality of life improvements associated with IMRT not only are maintained but apparently become more magnified over time. These data provide powerful evidence attesting to the long-term benefits of IMRT for head-and-neck cancer.International journal of radiation oncology, biology, physics 01/2012; 84(1):170-5. · 4.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a novel small-molecule ribonucleotide reductase inhibitor. This study was designed to estimate the maximum tolerated dose (MTD) and oral bioavailability of 3-AP in patients with advanced-stage solid tumors. Twenty patients received one dose of intravenous and subsequent cycles of oral 3-AP following a 3 + 3 patient dose escalation. Intravenous 3-AP was administered to every patient at a fixed dose of 100 mg over a 2-h infusion 1 week prior to the first oral cycle. Oral 3-AP was administered every 12 h for 5 consecutive doses on days 1-3, days 8-10, and days 15-17 of every 28-day cycle. 3-AP was started at 50 mg with a planned dose escalation to 100, 150, and 200 mg. Dose-limiting toxicities (DLT) and bioavailability were evaluated. Twenty patients were enrolled. For dose level 1 (50 mg), the second of three treated patients had a DLT of grade 3 hypertension. In the dose level 1 expansion cohort, three patients had no DLTs. No further DLTs were encountered during escalation until the 200-mg dose was reached. At the 200 mg 3-AP dose level, two treated patients had DLTs of grade 3 hypoxia. One additional DLT of grade 4 febrile neutropenia was subsequently observed at the de-escalated 150 mg dose. One DLT in 6 evaluable patients established the MTD as 150 mg per dose on this dosing schedule. Responses in the form of stable disease occurred in 5 (25%) of 20 patients. The oral bioavailability of 3-AP was 67 ± 29% and was consistent with the finding that the MTD by the oral route was 33% higher than by the intravenous route. Oral 3-AP is well tolerated and has an MTD similar to its intravenous form after accounting for the oral bioavailability. Oral 3-AP is associated with a modest clinical benefit rate of 25% in our treated patient population with advanced solid tumors.Cancer Chemotherapy and Pharmacology 11/2011; 69(3):835-43. · 2.80 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To determine if intra-patient dose escalation of the multi-targeted kinase inhibitor sorafenib is feasible in patients with advanced pretreated solid malignancies. An intra-patient dose escalation scheme starting at 400 mg BID was employed in this prospective trial. Doses were escalated to 600 mg BID for the second cycle and to 800 mg BID for the third cycle in the absence of grade 3+ adverse events. In the event of grade 3+ adverse events during cycle 1, doses were reduced to 400 mg daily through cycle 2. Dose re-escalation for cycle 3 was allowed in the absence of grade 3+ adverse events during cycle 2. Further dose escalation was prohibited. The primary endpoint was the overall percentage of patients tolerating dose escalation to 600 mg BID through cycle 2 or tolerating re-escalation to 400 mg BID through cycle 3. Fifty eligible patients with various solid tumors and a median of 3 prior therapies were enrolled. Eleven patients (22%) tolerated primary dose escalation or re-escalation. Only 14 patients (28%) completed cycle 1 without dose modification or discontinuing treatment. Seven of 13 patients tolerated primary dose escalation through cycle 2. Four of 5 patients tolerated dose re-escalation through cycle 3. Reasons for escalation failure included tumor progression (42%) and adverse events (26%). Common grade 3+ adverse events included hand-foot skin reaction, hypertension, and hypophosphatemia. Intra-patient dose escalation and/or re-escalation of sorafenib were not feasible in pretreated solid tumor patients. Sorafenib dose escalation remains an investigational approach.Investigational New Drugs 10/2011; 30(5):2001-7. · 3.50 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Epidermal growth factor receptor tyrosine kinase inhibitors given concurrently with chemotherapy do not improve patient outcomes compared with chemotherapy alone in advanced non-small cell lung cancer (NSCLC). On the basis of preclinical models, we hypothesized pharmacodynamic separation, achieved by intermittent delivery of epidermal growth factor receptor tyrosine kinase inhibitors intercalated with chemotherapy, as a reasonable strategy to deliver combination therapy. A phase I dose-escalating trial using two scheduling strategies (arms A and B) was conducted in patients with advanced solid tumors to determine the feasibility of intermittent erlotinib and docetaxel. Phase II efficacy evaluation was conducted in an expanded cohort of patients with previously treated advanced NSCLC using arm B scheduling. Docetaxel was given every 21 days (70-75 mg/m intravenously) in both arms. In arm A, erlotinib was administered on days 2, 9, and 16 (600-1000 mg); in arm B, erlotinib was delivered on days 2 through 16 (150-300 mg). Patients without progression or unacceptable toxicity after six cycles continued erlotinib alone. Eighty-one patients were enrolled in this study (17 arm A; 25 arm B; and 39 at phase II dose). Phase I patients had advanced solid tumors and 22 with NSCLC (10 and 12 patients for arms A and B, respectively). Treatment was well tolerated for both arms, with dose-limiting toxicities including grade 3 infection and febrile neutropenia in arm A (maximum tolerated dose [MTD] of erlotinib 600 mg/docetaxel 70 mg/m) and grade 4 rash, febrile neutropenia, grade 3 mucositis, and grade 3 diarrhea in arm B (MTD of erlotinib 200 mg/docetaxel 70 mg/m). The MTD for arm B was chosen for phase II evaluation given the feasibility of administration, number of responses (one complete response and three partial responses), and achievement of pharmacodynamic separation. The response rate for patients treated at the phase II dose was 28.2%, and the disease control rate was 64.1%. Median progression-free and overall survival were 4.1 and 18.2 months, respectively. Common grade ≥3 toxicities were neutropenia (36%) and diarrhea (18%). Pharmacodynamic separation using intercalated schedules of erlotinib delivered on an intermittent basis together with docetaxel chemotherapy is feasible and tolerable. Further studies using this approach together with interrogation of relevant molecular pathways are ongoing.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 09/2011; 6(12):2112-9. · 4.55 Impact Factor -
Article: Voice quality after organ-preservation therapy with definitive radiotherapy for laryngeal cancer.
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ABSTRACT: The purpose of this study was to analyze voice quality among patients treated by definitive radiotherapy for laryngeal cancer. Ten patients with laryngeal cancer who had completed radiotherapy were involved in this pilot study. A standardized protocol was administered assessing: (1) sustained vowel production following maximal inspiration, (2) sustained vowel production for a 7-second duration repeated 5 times, and (3) spontaneous speech for 10 seconds. The acoustic parameters among patients with early-stage cancer were not statistically different from healthy age-corresponding controls, except for shimmer (0.20 vs 0.16 dB, ρ = 0.01) and maximum phonation duration (24.37 vs 30.10 seconds, ρ = 0.04). For patients with locally advanced cancer, differences with controls were observed with shimmer (2.29 vs 0.16 dB, ρ = 0.01), jitter (7.49% vs 1.04%, ρ = 0.01), harmonics-to-noise ratio (2.67 vs 9.22, ρ = 0.01), and maximum phonation duration (14.12 vs 30.10 seconds, ρ = 0.01). Despite the subtle differences in voice quality that existed, radiotherapy as a curative treatment for laryngeal cancer allows maintenance of a functional voice.Head & Neck 08/2011; 34(7):943-8. · 2.83 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To evaluate the effect of continued cigarette smoking among patients undergoing radiation therapy for head-and-neck cancer by comparing the clinical outcomes among active smokers and quitters. A review of medical records identified 101 patients with newly diagnosed squamous cell carcinoma of the head and neck who continued to smoke during radiation therapy. Each active smoker was matched to a control patient who had quit smoking before initiation of radiation therapy. Matching was based on tobacco history (pack-years), primary site, age, sex, Karnofsky Performance Status, disease stage, radiation dose, chemotherapy use, year of treatment, and whether surgical resection was performed. Outcomes were compared by use of Kaplan-Meier analysis. Normal tissue effects were graded according to the Radiation Therapy Oncology Group/European Organization for the Treatment of Cancer toxicity criteria. With a median follow-up of 49 months, active smokers had significantly inferior 5-year overall survival (23% vs. 55%), locoregional control (58% vs. 69%), and disease-free survival (42% vs. 65%) compared with the former smokers who had quit before radiation therapy (p < 0.05 for all). These differences remained statistically significant when patients treated by postoperative or definitive radiation therapy were analyzed separately. The incidence of Grade 3 or greater late complications was also significantly increased among active smokers compared with former smokers (49% vs. 31%, p = 0.01). Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcomes. Further studies analyzing the biologic and molecular reasons underlying these differences are planned.International journal of radiation oncology, biology, physics 02/2011; 79(2):414-9. · 4.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The proteasome inhibitor bortezomib sensitizes tumor cells to chemotherapy-induced apoptosis. In preclinical non-small-cell lung cancer (NSCLC) models, p53-dependent growth arrest after bortezomib treatment resulted in reduced cytotoxicity if bortezomib preceded docetaxel. The reverse sequence of docetaxel before bortezomib was associated with increased apoptosis, cleavage of caspase-3 and PARP (poly [ADP-ribose] polymerase), and reduction in Bcl-2. A prospective randomized phase II trial of concurrent versus sequential docetaxel and bortezomib was conducted to assess whether administration sequence resulted in measurable clinical differences. Previously treated patients with advanced NSCLC were randomized to concurrent (CON) or sequential (SEQ) docetaxel (75 mg/m² intravenous [I.V.]) followed by bortezomib, every 3 weeks. In the CON arm, bortezomib (1.6 mg/m² I.V.) was given on days 1 and 8, and in the SEQ arm, it was given on days 2 and 8. Previous erlotinib as well as treated or controlled brain metastases were allowed. The primary endpoint was objective response rate (RR); progression-free (PFS) and overall survival (OS) were secondary endpoints. Eighty-one patients were randomized (40 CON and 41 SEQ). Grade 3+ toxicities were mostly due to myelosuppression. One patient each had grade 4 hyponatremia and syncope. Toxicities were similar between the arms. There was 1 treatment-related death in the SEQ arm. There were 8 partial responders, 4 in each arm, for an overall RR of 10%. Disease control rate was similar in both arms (50% vs. 49%). Median PFS was 12 weeks in the CON arm and 11 weeks in the SEQ arm. Median OS times in the CON and SEQ arms were 13.3 and 10.5 months, respectively. Docetaxel plus bortezomib given sequentially or concurrently has similar RR and PFS. Median survival in the SEQ arm exceeds published survival estimates for either agent alone or in combination. Any further studies in this population would require molecular characterization of a phenotype most likely to benefit from proteasome inhibitor therapy.Clinical Lung Cancer 01/2011; 12(1):33-7. · 2.04 Impact Factor - Fuel and Energy Abstracts 11/2010; 78(3).
- Fuel and Energy Abstracts 11/2010; 78(3).
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ABSTRACT: To determine how the addition of cisplatin-based concurrent chemotherapy to radiation therapy influences outcomes among a cohort of patients treated for head-and-neck cancer of unknown primary origin. The medical records of 60 consecutive patients treated by radiation therapy for squamous cell carcinoma of the head and neck presenting as cervical lymph node metastasis of occult primary origin were reviewed. Thirty-two patients (53%) were treated by concurrent chemoradiation, and 28 patients (47%) were treated by radiation therapy alone. Forty-five patients (75%) received radiation therapy after surgical resection, and 15 patients (25%) received primary radiation therapy. Thirty-five patients (58%) were treated by intensity-modulated radiotherapy. The 2-year estimates of overall survival, local-regional control, and progression-free survival were 89%, 89%, and 79%, respectively, among patients treated by chemoradiation, compared to 90%, 92%, and 83%, respectively, among patients treated by radiation therapy alone (p > 0.05, for all). Exploratory analysis failed to identify any subset of patients who benefited from the addition of concurrent chemotherapy to radiation therapy. The use of concurrent chemotherapy was associated with a significantly increased incidence of Grade 3+ acute and late toxicity (p < 0.001, for both). Concurrent chemoradiation is associated with significant toxicity without a clear advantage to overall survival, local-regional control, and progression-free survival in the treatment of head-and-neck cancer of unknown primary origin. Although selection bias cannot be ignored, prospective data are needed to further address this question.International journal of radiation oncology, biology, physics 10/2010; 81(2):346-52. · 4.59 Impact Factor -
Article: Primary radiation therapy for head-and-neck cancer in the setting of human immunodeficiency virus.
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ABSTRACT: To analyze outcomes after radiation therapy for head-and-neck cancer among a cohort of patients with human immunodeficiency virus (HIV). The medical records of 12 patients with serologic evidence of HIV who subsequently underwent radiation therapy to a median dose of 68 Gy (range, 64-72 Gy) for newly diagnosed squamous cell carcinoma of the head and neck were reviewed. Six patients (50%) received concurrent chemotherapy. Intensity-modulated radiotherapy was used in 6 cases (50%). All patients had a Karnofsky performance status of 80 or 90. Nine patients (75%) were receiving antiretroviral therapies at the time of treatment, and the median CD4 count was 460 (range, 266-800). Toxicity was graded according to the Radiation Therapy Oncology Group / European Organization for the Treatment of Cancer toxicity criteria. The 3-year estimates of overall survival and local-regional control were 78% and 92%, respectively. Acute Grade 3+ toxicity occurred in 7 patients (58%), the most common being confluent mucositis (5 patients) and moist skin desquamation (4 patients). Two patients experienced greater than 10% weight loss, and none experienced more than 15% weight loss from baseline. Five patients (42%) experienced treatment breaks in excess of 10 cumulative days, although none required hospitalization. There were no treatment-related fatalities. Radiation therapy for head-and-neck cancer seems to be relatively well tolerated among appropriately selected patients with HIV. The observed rates of toxicity were comparable to historical controls without HIV.International journal of radiation oncology, biology, physics 04/2010; 79(1):60-4. · 4.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To determine the effect of prophylactic gastrostomy tube (GT) placement on acute and long-term outcome for patients treated with definitive chemoradiotherapy for locally advanced head and neck cancer. One hundred twenty consecutive patients were treated with chemoradiotherapy for Stage III/IV head and neck cancer to a median dose of 70 Gy (range, 64-74 Gy). The most common primary site was the oropharynx (66 patients). Sixty-seven patients (56%) were treated using intensity-modulated radiotherapy (IMRT). Seventy patients (58%) received prophylactic GT placement at the discretion of the physician before initiation of chemoradiotherapy. Prophylactic GT placement significantly reduced weight loss during radiation therapy from 43 pounds (range, 0 to 76 pounds) to 19 pounds (range, 0 to 51 pounds), which corresponded to a net change of -14% (range, 0% to -30%) and -8% (range, +1% to -22%) from baseline, respectively (p < 0.001). However, the proportion of patients who were GT-dependent at 6- and 12-months after treatment was 41% and 21%, respectively, compared with 8% and 0%, respectively, for those with and without prophylactic GT (p < 0.001). Additionally, prophylactic GT was associated with a significantly higher incidence of late esophageal stricture compared with those who did not have prophylactic GT (30% vs. 6%, p < 0.001). Although prophylactic GT placement was effective at preventing acute weight loss and the need for intravenous hydration, it was also associated with significantly higher rates of late esophageal toxicity. The benefits of this strategy must be balanced with the risks.International journal of radiation oncology, biology, physics 03/2010; 78(4):1026-32. · 4.59 Impact Factor
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Far be it from me to doubt Drake's knowledge of the female gender, but it doesn't take a Don Juan to determine that Girls Love Beyoncé. Obvious thesis aside, though, the latest effort from Aubrey Graham is well-deserving of fellas' rapt attention. (It's a foregone conclusion that the ladies will be listening.) Released earlier today via his OctobersVeryOwn blog, this album inclusion features the YMCMB megastar reflecting on his love life, and lamenting his perennial fear of commitment over low-key, R&B-informed boardwork by constant collaborator Noah "40" Shebib. On the back, he sums up his predicament: "I'm just trying to find a reason not to go out every evening / I need someone that'll help me think of someone besides myself." Cocaine 80s frontman James Fauntleroy guests, deftly recontextualizing Destiny's Child's Say My Name on the chorus. Drizzy is currently wrapping up his highly-anticipated junior set, Nothing Was the Same. The project as yet lacks a solid drop date, but we'll keep you supplied with release details and fresh tunes as they emerge.
Written by richard on 04/16/13
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YMCMB/Universal Motown
First DJ Booth Appearance:
"Brand New (Remix) ft. Lil' Wayne" (2008)
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DALLAS (AP) - Hall of Fame coach Larry Brown is headed back to Madison Square Garden, this time taking his SMU Mustangs to the NIT semifinals.
SAN ANTONIO (AP) - Phil Mickelson made his only other Texas Open appearance in 1992, so long ago that the event was only his 11th professional start on the PGA Tour.
KEY BISCAYNE, Fla. (AP) - Novak Djokovic benefited from an erroneous call and claimed he didn't realize he had broken the rules. When Andy Murray walked to the net and challenged him about it, Djokovic responded with a shrug and a sheepish smile.
EDMONTON, Alberta (AP) - Joe Pavelski scored three goals and set up another as the San Jose Sharks snapped a two-game losing streak with a 5-2 victory over the struggling Edmonton Oilers on Tuesday.
NEW YORK (AP) - Zack Greinke and the Los Angeles Dodgers have knocked Alex Rodriguez and the New York Yankees off baseball's payroll perch, part of an offseason spending spree that has the average salary approaching $4 million for the first time.
SAN FRANCISCO (AP) - Professional athletes frequently get traded to other teams, but San Francisco 49ers tight end Vernon Davis is about to be the first ever to be traded like a stock.
BUFFALO, N.Y. (AP) - Hall of Fame quarterback Jim Kelly is expected to have surgery again following the recurrence of cancer that his wife described as aggressive and "starting to spread."
ALAMEDA (AP) - Oakland Raiders fullback Jamize Olawale has signed his exclusive rights tender.
PHOENIX (AP) - Wily Peralta hit his second homer of spring training and allowed one run over 6 1/3 innings but the Milwaukee Brewers lost to the San Francisco Giants 5-4 Tuesday.
PHOENIX (AP) - Brandon Moss hit a three-run homer and Josh Reddick had a solo home run to help power the Oakland Athletics to an 8-4 victory over the Cincinnati Reds on Tuesday.
LOS ANGELES (AP) - Xavier Henry scored 22 points, Nick Young hit five 3-pointers while scoring 20 points, and the Los Angeles Lakers dropped a franchise-record 51 points in the third quarter of their 127-96 victory over the New York Knicks on Tuesday night.
KEY BISCAYNE, Fla. (AP) - Andy Murray heard a fan clamoring for a souvenir towel and tried to oblige by tossing one toward the courtside seats.
WACO, Texas (AP) - Cory Jefferson figures not too many people really know just how good Baylor has been in postseason play.
LOS ANGELES (AP) - "The Young and the Restless" took a break from love, deception and backstabbing to celebrate the soap's 41st anniversary on Tuesday.
SACRAMENTO, Calif. (AP) - Royce White leaned back in a chair in the Sacramento Kings locker room, looked at the veteran players around him and joked about why he'd be the one getting an interview request.
ARLINGTON, Texas (AP) - Face-down on the turf, Tony Romo pounded his hands into the ground like a petulant child.
BOSTON (AP) - As a Los Angeles Dodgers broadcaster, Nomar Garciaparra watched Clayton Kershaw become the dominant pitcher in the National League, winning three of the last four NL Cy Young Awards - the last one unanimously.
Ripon Christian put up 22 points in the first and third quarters on the way to a 78-58 non-league boys basketball win over visiting Big Valley Christian-Modesto on Saturday.
AUBURN HILLS, Mich. (AP) - Brandon Jennings scored 35 points as the Detroit Pistons beat the Sacramento Kings 114-95 Sunday for their fifth straight win.
INDIANAPOLIS (AP) - When Andrew Luck was under pressure Sunday, he stood tall and maintained his poise.
Eighty years ago, on January 1, 1935, Mr. and Mrs. J. L. Barber witnessed the annual East-West Shrine football game at San Francisco's Kezar Stadium. Their son, Jim, was a member of the West team and made the first touchdown of the game when he ran 19 yards after taking a blocked punt. Jim was captain of the University of San Francisco team during the past season and his brother, Ernest, was a member of the same team.
NEW YORK (AP) - Stuart Scott was in his element, working a "Monday Night Football" game, when he was forced to leave for an appendix operation.
ZAGREB, Croatia (AP) - American skier Mikaela Shiffrin continued her recent resurgence in slalom by convincingly winning her second straight World Cup race, leaving her rivals in awe four weeks before she defends her world title in Beaver Creek.
RALIEGH, N.C. (AP) - Joe Flacco continued his impressive postseason performances, throwing for two second-half touchdowns to beat the Ravens' bitter AFC North rival. The Ravens (11-6) won in Pittsburgh for the first time in the postseason; Pittsburgh had been 9-0 in third games of a season against the same opponent.


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Refurbished Exotic Sport Super Sports RTR Electric RC Car
regular price: $49.99
Out of Stock
Ships Tomorrow!
5 Rating (0 Customer Reviews)
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This is a refurbished RC vehicle. This unit comes with a 90 day warranty. We have our highly trained technical staff repair and test our refurbished products to make sure they are in perfect working order. This is the new Exotic Sport Super Sports RTR Electric RC Car. This RC car comes with a full function radio control that allows for forward, backward, left, right, and stop movement. The innovative hinged chassis allows for smoother movement and sharper turns. It comes with working headlights that allow you to drive in the light or in the dark. This car has a realistic interior cockpit and great attention to detail. This Ready-to-Run (RTR) RC car comes with a rechargeable battery and wall charger. All you need is to charge the battery and to insert 2 not included AA Alkaline batteries into the transmitter and you are ready to go!
- Full Function Radio Control
- Hinged Chassis Allows for Sharper Turns
- Flashing Head Lights
- Realistic Interior Cockpit
- Exotic Sport Super Sports RTR Electric RC Car
- 6V Rechargeable Battery Pack
- AC Wall Charger
- Length: 12 Inches
- Width: 5.5 Inches
- Height: 3 Inches
Battery Requirements:
- Vehicle: 6V Rechargeable Battery Pack (Included)
- Transmitter: 2 AA Alkaline Batteries (Not Included)
Safe & Secure online shopping guaranteed.
Call our Customer Service at 818-675-9000 if you find a lower price on any of our items we'll match it.*
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Get loads of free Christmas related wallpapers on your phone. You can choose from Christmas, Winter, Holidays, New year and Santa related wallpapers. Set your wallpaper right from the app. Enjoy the wallpapers and Merry Christmas!
You must install this app before submitting a review.
Google Play reviews now use Google+ so it's easier to see opinions from people you care about. New reviews will be publicly linked to your Google+ profile. Your name on previous reviews now appears as "A Google User".
Google Play reviews now use Google+ so it's easier to see opinions from people you care about. New reviews will be publicly linked to your Google+ profile. Your name on previous reviews now appears as "A Google User".
Write a review
My review
Review from
All Versions
All Versions
Latest Version
63 total
5 27
4 8
3 8
2 6
1 13
A Google User
If there was a no star id put it! Tons of amazing christmas pics but i was asking for wallpapers, not pics! No save or set option!
A Google User
All Things Christmas! Great wallpaper, and easy to use. Works great on my HTC hero s
A Google User
Only Christmas pictures. Looking for New Year (like description says). Uninstalled.
A Google User
Very cool. Lots of free pics to choose from. Great quality pictures. If the file was smaller, it would get 5 stars!
A Google User
The pics are ok but it doesn't adjust to the size of your screen so you get giant pictures.
A Google User
Love it! Great quality pics:u
User reviews
If there was a no star id put it! Tons of amazing christmas pics but i was asking for wallpapers, not pics! No save or set option!
All Things Christmas! Great wallpaper, and easy to use. Works great on my HTC hero s
Only Christmas pictures. Looking for New Year (like description says). Uninstalled.
Very cool. Lots of free pics to choose from. Great quality pictures. If the file was smaller, it would get 5 stars!
The pics are ok but it doesn't adjust to the size of your screen so you get giant pictures.
No save option. Some nice photos but slow. Photos & cartoon style graphics have good detail for wallpapers.
Additional information
December 7, 2010
10,000 - 50,000
Current Version
Requires Android
1.5 and up
Content Rating
Flag as inappropriate Offered By
Value Apps
The Nightmare Before Christmas
※Jellybean user if an error occurs during the installation of those
Please mail to firstname.lastname@example.com will guide you how to fix.
The Nightmare Before Christmas AC Introduction to the theme
Please mail to email@example.com will guide you how to fix.
The Nightmare Before Christmas AC Introduction to the theme
Annie Tim Burton,The Nightmare Before Christmas 3d
Interesting story and the characters' representation
Received a lot of love on the topic of animation
Nice background and icon (including character icons)
The Nightmare Before Christmas theme designed
It's The Nightmare Before Christmas Go launcher theme
- 100 icons
- 5 main wallpapers
- 5 app drawer wallpapers
- 4 dock bar wallpapers
- Tim Burton's The Nightmare Before Christmasy addition 8 character Icon
- clock widjet (is not include theme)
※ How to use DIGI Clock Skin ※
1.Google Store-Installation Free DIGI Clock
2.Touch and hold Desktop-Widget-DIGI Clock Widget 1×4(Wide)
3.Touch and Short DIGI Clock-DIGI Clock Settings
(Date position-Top , Bottom-settings)
4.Background settings-Choose background
5.http://blog.naver.com/seungjo69-multi go launcher-The theme Attachments down
6.the Save folder Clock Skin Application
How to use...
1. Search "Go launcher EX" and download and install
2. Install this theme
3. Run Go Laucher EX
4. Menu> preferences> theme preferences> choose
a this theme
More from developer
Android users rejoice. Your phone is now a fully functional analog/digital speedometer. At the same time the app is also a speed alarm to save you from speeding tickets.
Speedometer Features
This app is a GPS Speedometer for your smartphone. The features include:
* Analog and digital speedometer based on your mobile phone's built in GPS
* Supports different scales including Kilometers per hour (km/h), meters per second, miles per hour (mph) and knots speed scales.
* You can change this scale any time on the move.
* This mobile speedometer also features a speed alarm. Set a speed cap and your phone will warn you.
* You can enable or disable alarm
* Great design and easy to use application on all popular mobile platforms.
Features in detail
This mobile GPS speedometer features a fully functional speedometer with both analog as well as digital speed display. Analog meter shows speed just like your car's speedometer using a dial and a needle. Digital speedometer will show current speed in digits.
Speed Alarm
You can set an alarm for a specific speed. As soon as you go beyond that speed, the alarm will start buzzing. It will alert you if you go beyond your speed limit. You can have many possible ways you can use this alarm. See following section.
Where to use?
Either you are in a bus, train or any other public transport and wonder what is the current speed of this vehicle, Speedometer to your rescue. Just launch the app, wait for a couple of seconds for the GPS to lock and you are ready to go.
Please do not use the app while you are driving. If you want to change settings or modify the alarm, first park your car on the road side and then operate your mobile phone. Using mobile phone while driving is dangerous for you and other people on the road.
Container Run
Mr. Khan is ready to go to Islamabad. He has his goal set, tank filled, companions ready, vision clear and confidence high. Only thing standing between him and his goal is the evil powers from the transportation world, they call them "Containers".
M2 has almost no traffic due to the containers, but the obstacles are definitely a pain. Help Mr. Khan jump and wade his way through the huge containers.
* Realistic 3D Graphics
* Stylish Mr. Khan
* Containers of different shapes and sizes
* Jump over containers
* Run on containers
* Blow up containers with rockets
* Easy to play
How to Play
* Tilt your device to turn right and left.
* Touch anywhere on screen to jump
Thats it, go-ahead. Enjoy!
Santa Tracker - 2014
Watch Santa on the map, track him down using our satellite system. An amazing 3D space environment and we track down Santa's location on the map. Features include
* Find Santa on Map
* Countdown to Christmas
* A beautiful Christmas tree
* Stunning 3D graphics
* Beautiful background meausic
More features coming soon.
Get this amazing app today!
Doodle Parachute Attack
You are the last hope for the citizens of Calmsfield. A calm little town in the middle of no-where which is rich with natural resources but has a very poor military defense, Calmsfield relies on you to defend its population, lakes, sea shores, houses, boats and people. You have to use the minimum resources to defend the state.
As a defending army, you have to kill any possible para-dropped enemy forces using your cannons and machine guns. Any single enemy unit that lands on the ground will start destroying your buildings, houses, army barracks and boats. Make sure you don't let a single enemy unit land on ground.
Your defense isn't that strong but with regular intervals you will be receiving upgrades and perk ups to make a better defending side. You'll start off with a basic cannon firing small bombs at those invading parachutes and you'll progress your way through better cannons, more bombs, more powerful gun powder, greater capability of killing the paratroopers and dropping air-crafts and more.
If you are not a very one-shot-at-a-time kind'a person, you can upgrade your cannon to have more than one bombs very soon or you can eventually earn a machine-gun upgrade to kill those enemy units with a few bullet shots.
As the game progresses, the frequency of enemy drops and the speed of their descent will make you fire like a champ, or you'll start losing your important national assets to those infiltrators. But you are not alone with the ever growing enemy strength. You'll soon be able to fire multiple bombs to kill those in-coming planes and parachutes to score better points and earn those star bonuses. More stars you earn, better are your chances of repairing your assets in later stages.
If you become invincible and the attacking army fails to break your defense, they'll send even more waves of paratroopers to a limit when a deadly harrier boss will bring a combination of strong armor and a high frequency of parachute drop. Only way to survive is to kill that boss and break that armor.
What are you thinking commander? Pick up your kit and go stand-by that cannon. We're sending you reinforcements very soon.
Best of luck!
Game Features!
* Great game play with realistic game physics for higher level of engagement.
* Great doodle graphics
* Beautiful music and combat ambiance
* Fully stereo sound effects for an enjoyable game play with speakers or head-phones or even on the amazing PlayBook stereo speakers.
* Five different cannons for higher level of defense.
* Five different machine guns for an automatic firing at the parachutes.
* Easy switch between machine gun and cannon
* Possibility of firing multiple bombs for a quick firing at multiple invaders
* Killing air-planes to slow down enemy descent
* Realistic paratroopers jumping off the falling planes
* Bonus stars that let you re-build and repair your infrastructure
* A very fierce boss to keep you busy for a long battle
Please be warned that the invading army is composed of highly skilled commandos and you will not be able to kill them once they've landed. Kill them in the air or prepare to lose the war.
This is all out war and no mercy for the feeble.
You'll only win this war if you kill all the invading army units.
The moment you lose all your ground asset, you'll lose the game.
Best of luck again!
Al Fatiha
Surah-Al-Fatiha, the first Surah of Holy Quran, text in Arabic, Translation in English and Recitation from Imam-e-Kaaba, Masjid Al Haram, Makkah.
The simple app has the text and recitation of the first surah of Holy Quran
Update 1.2 ** Translation Added
Keywords: Islam, Quran, Koran, Fatiha, Surah, Muslim,
Aaj Kya Pakaen-آج کیا پکاءیں
What are you cooking today? Let this app decide for you. The app suggests a new food item to be cooked or eaten. Don't like the suggestion? Keep trying till you find what you were looking for.
Once you've decided what you're cooking, go through the recipes in Urdu or English and cook your delicious meal.
Dozens of delicious recipes from Pakistan and South Asia included.
Not happy with the dishes included? Add your own.
Download now!
Refuel Racing
Race through city traffic with an eye on your fuel and car health.
This urban racing game keeps you on your toes. Drive through the general traffic on the road and drive as far as you can to score the most points. The game puts you behind the steering wheel of this sizzling red sports car that races through the traffic to take you far away, but there's a twist.
Faster you drive, the more fuel it consumes. Don't worry, we have mobile re-fueling stations driving all across the road. Just drive into the fuel container of the truck and your car will refuel.
Make sure you don't hit the traffic or your car will break down. The key to success is to go as far as you can, though faster you go, more traffic you hit, more fuel you consume, so you have to keep a poise between the speed and reliability.
Best of luck, go smoke those tires and make a name for yourself on the race track.
How to Play:
* Touch the screen to accelerate
* Hit the fuel-truck (blue truck) to re-fuel while racing.
* Pick up the finger to slow down
* Tilt your phone side-ways to turn
* Tilt your phone up or down to move car forward or backward
* Avoid the school bus to avoid bigger damage
* There is not damage when you touch the fuel truck.
* Follow the sedans to go faster
* Slower you drive, lesser fuel you spend.
* Tractors, vans and Armor trucks are the slowest, avoid them.
Christmas Greetings 2013
Christmas is around the corner and this app brings you a number of greeting cards, designed and hand picked for your mood and to make sure you always have a few cards to send out to your family, friends, loved ones and special ones.
Send our greeting cards on this Christmas and spread smiles.
* More than 80 Christmas specific greeting cards.
* Share it on Gmail, Email, Facebook, Twitter and more...
* Edit and type your own message when sending the card.
* Works on all popular handsets
* Works in both landscape and portrait modes.
If you have questions, suggestions or issues with the app, please feel free to contact our support email addres: firstname.lastname@example.com
Ramadan Timing
This app is about timings in Ramadan (Ramzan, Ramzan) for starting and breaking the Fast (Saum, Roza) both during the month of Ramadan and throughout the year.
This app calculates timings for starting and breaking your fast. Ramadan, Islamic month of blessings and fasting, requires all Muslims to exercise fasting. This app will help you calculate your Ramadan timing based on your GPS location, your current time zone and astronomical calculation methods agreed upon by most authentic Islamic universities and scholarly institutions.
The app is very useful for those who travel, have no mosque nearby or have no Ramadan calendar, or just want to verify their current calendar. You can also use this app for calculating saum (roza, fasting) timings for any day throughout the year.
The features include
* Calculates the timing of starting and breaking your fast (roza, saum)
* Calculation is based on your GPS location - automatically detects your current location
* Correct timings based on your current time, time-zone, location and several astronomical factors.
* Customizable variables like calculation methods, location and time zone.
The calculation methods used to work out the Fajr and Maghrib timing supported by this app include:
* Muslim World League - MWL
* Islamic Society of North America - ISNA
* Egyptian General Authority of Survey
* Umm al-Qura University, Makkah
* University of Islamic Sciences, Karachi
* Institute of Geographics, University of Tehran
* Shia Ithna Ashari (Ja'fari)
Tips for correct Ramadan timing calculation.
* Please make sure your phone date and time is correctly set.
* Please make sure your phone's time zone is correctly set.
* Please detect your location to view your timing.
* If your app is not detecting your location indoors, please go outdoors to detect your location (needed once).
Shaukat Khanum Mobile App
Official app for Shaukat Khanum Memorial Cancer Hospital and Research Centre.
The app brings you the information, news and events related to Shaukat Khanum Memorial. You can access lab reports and the app also gives you several options on how to donate for the hospital.
Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC) is a state-of-the-art cancer centre located in Lahore, Pakistan. It is a project of the Shaukat Khanum Memorial Trust, which is a charitable organization established under the Societies Registration Act XXI of 1860 of Pakistan. The institution is the brainchild of Pakistani cricket superstar, Imran Khan. The inspiration came after the death of his mother, Mrs. Shaukat Khanum, from cancer.


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Idiot Wind | E4 5c | ||
15m. 14m. Bold and high in the grade. Climb the unprotected arete with trepidation to the break. Move left to jugs on the edge of the roof and pull onto the final wall strenuously. Finish more easily. © ROCKFAX
Photo: Idiot Wind E4 5c © S Lynch | |||


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Ladbrokes Fans Take On Digital Role FIVB Partners With Red Bull Joint Venture Innovate Aquires Wexford Park Rights Dunkin' Donuts Sorry For Mock LFC Crest Man City Signs Deal With Surf Soccer Man City Waits On Outcome Of FFP Case FEI Scraps Endurance Events In UAE Chelsea Signs $308M Deal With Yokohama Push For Vacation Days During Olympics Sky Sports Acquires MLS TV Rights
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Upcoming Conferences and Events
SBD Global/June 27, 2013/Events and Attractions
Maria Sharapova Leads Criticism Of Wimbledon Grass Courts, Calling Them 'Dangerous'
Published June 27, 2013
SLIP AND SLIDE: In London, Briggs & Rumsby reported Victoria Azarenka "attacked the All England Club for preparing slippery courts." Azarenka "fell painfully in her opening match on Monday against Maria Joao Koehler, letting out a blood-curdling shriek." Even though she managed to beat her opponent 6-1 6-2, her knee "has stiffened up over the last two nights, and she was forced to withdraw from the tournament on Wednesday morning." Asked on Monday if she felt there was anything different about the courts this year, Azarenka replied, "I'm wondering the same question because the court was not in a very good condition that day. My opponent fell twice; I fell badly; there were some other people who fell after. So I don't know if it's the court or the weather. I can't figure it out. It would be great if the club or somebody who takes care of the court just would examine or try to find an issue so that wouldn't happen" (TELEGRAPH, 6/26).
FIXING THE COURT: ESPN's Patrick McEnroe said while everybody "loves the way it looks" on the opening day of the tournament, Wimbledon officials moving forward are "going to have to seriously consider having a little bit more play in the week leading up" to the start of the event. ESPN's Mary Joe Fernandez said that "perhaps there is something that can be done" to fix the courts, including changing the fact that Centre Court and Court One get "no play on (them) until the Championships." Fernandez: "You have to start getting someone to practice on it." Meanwhile, ESPN's Pam Shriver said, "I want to know what the shoe manufacturers are doing to test the grass court shoes as grass courts are changing and maybe the surfaces under the grass are being rolled more." ESPN's Brad Gilbert read a tweet from former tennis player Kim Clijsters about the All-England Club and said, "A few years ago they made a new rule about the position and the length of the studs on the shoes to protect the pristine grass." ESPN's Mike Tirico, on shoe regulations at Wimbledon: "There are very specific rules. We could bore you with diameter and pimple density here for a minute but needless to say, they are very careful about what exactly you can wear. But whatever people are wearing, it's not working" ("Wimbledon," ESPN2, 6/26).


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2013 Subaru XV Crosstrek for Sale in Edmonton, Alberta
2013 Subaru XV Crosstrek
Sport Pkg CVT
- Stock #: P5801
- Trim: Sport Pkg CVT
- Exterior Colour: Grey
- Interior Colour: N/A
- Number of Doors: 4
- Engine: 2.0L H 4
- Transmission: CVT
- Drive Type: AWD
- Upholstery: None
- Odometer: 54,374 Kms
Finance options available on site here at Southgate Volkswagen and trade ins are welcome. Call one of our friendly professional certified sales staff today to enquire, test drive and own today. Buy with confidence at Southgate VW representing Edmonton and the area for over 40 years. Come shop in our exclusive heated indoor 150 unit showroom and see why you can buy here with confidence, we only keep the best and sell for less!
Southgate Volkswagen
5220 Gateway Blvd.
Edmonton, Alberta
Phone:(780) 438-8888


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Ski Rennen Metal Sign
Rebuilt after the fire of 1861, Glarus is a great place to take to the slopes for some winter fun in this vintage sign for skiing in Switzerland. More
Welcome to Personalized Sign Shop! Our gallery of signs is colossal and ever-expanding. We are all signs all the time.$24.99 | MORE DETAIL |
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May also be called: DKA
Diabetic ketoacidosis (DKA) (kee-toh-ah-sih-DOH-sis) is a life-threatening condition that happens when the body uses fat for energy instead of glucose.
Glucose (a type of sugar) is the body's main energy source. But when the body can't use glucose for fuel — for instance, in someone with uncontrolled diabetes — the body breaks down fat for energy instead.
When fat is broken down, the body produces chemicals called ketones, which appear in the blood and urine (pee). High levels of ketones cause blood to have a high acid level.
Diabetic ketoacidosis is life threatening and requires immediate medical evaluation and treatment.
All A to Z dictionary entries are regularly reviewed by KidsHealth medical experts.
Note: All information is for educational purposes only. For specific medical advice, diagnoses and treatment, consult your doctor.
© 1995–2014 The Nemours Foundation/KidsHealth. All rights reserved.
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Download Winter 2015 (PDF)
Vaccine is the best way to prevent seasonal flu. Everyone 6 months of age and older should get the flu vaccine each year, whether it's as a shot or as a nasal spray. Your healthcare provider can help you choose the right form. Get the vaccine for your family as soon as you are able, and be sure to ask anyone who takes care of your child to get the...
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La vacuna es lo mejor para prevenir la influenza o gripe de la temporada. Desde los 6 meses en adelante, todos debemos vacunarnos cada año. Algunas vacunas para la influenza se inyectan y otras se dan por la nariz, en aerosol. Su médico puede ayudarle a escoger la mejor para usted. Lleve a su familia a vacunarse en cuanto pueda y asegúrese de que...
Miracle Season, hosted by Dan Lewis and Molly Shen, aired Dec. 7, 2014 on KOMO 4 TV. The annual holiday special celebrates the remarkable lives of Seattle Children's patients. To donate now, visit https://giveto.seattlechildrens.org


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- 353Promote
Tote Bag
Our quality crafted Tote Bags are hand sewn in America using durable, yet lightweight, poly poplin fabric. All seams and stress points are double stitched for durability. Available in 13" x 13", 16" x 16" and 18" x 18" variations, the tote bags are washable, feature original artwork on both sides and a sturdy 1" wide cotton webbing strap for comfortably carrying over your shoulder.
With the desire to send more customers to your S6 store, I've posted this image at: http://pinterest.com/pixel404/s6-random-favorites/ Here's another link that might be of interest: http://blog.shareaholic.com/2012/01/p...l-traffic/ The data in the shareaholic article is from January... Pinterest has grown considerably since then! Cheers!
I adore this design, Carina! Promoted on my FB Page http://www.facebook.com/iPhoneAvenue. :)
:)))))) I'd love to know all your findings lol, houses are always something funny and interesting to look into :D - Thank you Bob!!!
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I know for a fact ahri would dominate amumu cause i have played a few thinking a tanky champ would counter me. Really i can't imagine amumu having what it takes to win a lane with any of the high ranged mages.
Hughes De Payens
Senior Member
I'm 99% sure I'd wipe the floor with amumu as Cassiopeia. It just doesn't seem like he has a chance.
I once randomed garen and won mid. Garen new meta mid laner
Dry Ace
100% sure your get rocked so hard by a competent brand you'll never do it again


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This product has either been sold or removed from the web site. If you are interested in the product, please email us to ask about the availability of this product and include the product style number in your e-mail. We will then contact you by e-mail to let you know the product availability.
Metal Type: | Sterling silver |
Main stone: | Two brilliant cut genuine diamonds, blue cubic zirconias |
Item Weight: | 8.10 g |
Item Length: | 2.00 cm |
Gift wrapping is available upon checkout.
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