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Publications (15)22.57 Total impact
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ABSTRACT: In this paper, for the first time, an on-chip optofluidic imaging system is innovated to measure the biophysical signature of single waterborne bacterium, including both the refractive index and morphology (size and shape), based on immersion refractometry. The key features of the proposed optofluidic imaging platform include (1) multiple sites for single bacterium trapping, which enable parallel measurements to achieve higher throughput, and (2) chaotic micromixer, which enable efficient refractive index variation of the surrounding medium. In the experiments, the distinctive refractive index of Echerichia coli, Shigella flexneri and Vibrio cholera are measured with a high precision of 5×10-3 RIU. The developed optofluidic imaging system has high potential not only for building up a database of waterborne bacterium biophysical signature, but also developing single bacterium detection in treated water that is real-time, label-free and low cost.Lab on a Chip 08/2014; · 5.70 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Bacteriophages are considered as attractive indicators for determining drinking water quality since its concentration is strongly correlated with virus concentrations in water samples. Previously, bacteriophage detection was based on a plague assay that required a complicated labelling technique and a time-consuming culture assay. Here, for the first time, a label-free bacteriophage detection is reported by using droplet optofluidic imaging, which uses host-cell-containing microdroplets as reaction carriers for bacteriophage infection due to a higher contact ratio. The optofluidic imaging is based on the effective refractive index changes in the microdroplet correlated with the growth rate of the infected host cells, which is highly sensitive, i.e. can detect one E. coli cell. The droplet optofluidic system is not only used in drinking water quality monitoring, but also has high potential applications for pathogenic bacteria detection in clinical diagnosis and food industry.Lab on a Chip 07/2014; · 5.70 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: This paper presents a biophysical method to characterize single bacterium in water by using an on-chip optofluidic immersion refractometer. Water safety is a major factor in the well-being of people, but the presence of bacteria such as Escherichia coli (E. coli), bacillus subtilis, Shigella flexneri and vibrio cholera in drinking water can lead to infectious diseases such as typhoid fever. Hence, it is crucial to detect and identify bacteria to prevent bacterial outbreaks. In this paper, an optofluidic immersion refractometer is developed to measure three biophysical parameters, i.e. size, shape and refractive index. The refractive index of a single bacterium is measured in high sensitivity of 0.005 RIU. This system is an innovative method to allow on-site real-time detection of single bacterium in water. It significantly reduces the amount of detection time and do not require trained personnel or additional chemical and biological reagents.Procedia Engineering 01/2014; 87:356-359. -
Conference Paper: Protozoon classifications based on size, shape and refractive index using on-chip immersion refractometer
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ABSTRACT: This paper presents an on-chip immersion refractometer for the measurement of size, shape and refractive index of protozoa in treated water. The key features of the on-chip immersion refractometer include (1) multiple single cyst trapping sites, which enable the measurement of multiple sample per test; and (2) zig-zag micromixer, which enables the refractive index variation of external medium as the key component of immersion refractometry. The results show that C. parvum oocysts have size of 3 to 7 μm, spherical with ovality lower than 0.3, and refractive index of 1.418. G. lamblia cysts have size of 8 to 12 μm, oval with ovality higher than 0.3, and refractive index of 1.433. The refractive indices of the samples are measured with high precision of <;10<sup>-3</sup>.Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International; 07/2011 -
Article: An optofluidic volume refractometer using Fabry-Pérot resonator with tunable liquid microlenses.
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ABSTRACT: This letter reports the development of an optofluidic Fabry-Pérot (FP) resonator, which consists of a microcavity and a pair of liquid microlenses. The microcavity forms part of the microchannel to facilitate sample injection. The liquid microlenses are used for efficient light coupling from the optical fiber to the microcavity. The liquid microlens collimates the diverging light from the optical fiber into the FP cavity, which provides real-time tuning to obtain the highest possible finesse up to 18.79. In volume refractive index measurement, a sensitivity of 960 nm per refractive index unit (RIU) and a detection range of 0.043 RIU are achieved.Biomicrofluidics 01/2010; 4(2). · 3.77 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We report a novel method for measuring the effective refractive index (RI) of single living cell using a small integrated chip, which might be an efficient approach for diseases diagnosis. This microchip is able to determine the refractive index of single living cell in real time without any extra cell treatments such as fluorescence labelling, chemical modification and so forth, meanwhile, providing low cost, small size, easy operation and high accuracy. The measurement system integrates an external cavity laser, a microlens, and some microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RI are utilized to calibrate the measurement system and five different types of cancerous cells are subsequently measured in the chip. The experimental results show that the refractive indices of the cancerous cells tested ranges from 1.392 to 1.401, which is larger than typical value of normal cell of 1.35–1.37. This integrated chip potentially has a serial of applications on biodefense, disease diagnosis, biomedical and biochemical analysis.Sensors and Actuators A Physical 02/2007; · 1.94 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A microfluidic cell sorting chip has been developed using micromachining technology, where electroosmotic flow (EOF) is exploited to drive and switch cells. For this electroosmotically driven system, it is found that the effect of induced hydrostatic pressure caused by unequal levels in solution reservoirs is not negligible. In this work, the numerical simulation of EOF and opposing pressure induced flow in microchannels is presented and the velocity profiles in the microchannels are measured experimentally using microparticle imaging velocimetry (PIV) system. The result shows that the final resulting velocity is the superposition of the two flows. A total volume of 0.305 μl is transported in the 50 μm microchannel and the back flow occurs after 240 s transportation. The task of sorting cells is realized at the switching structure by adjusting the electric fields in the microchannels. The performance of the cell sorting chip is optimized by investigating the effect of different switching structures. A Y-junction switching structure with 90° switching angle is highly recommended with simulated leakage distance of 53 μm and switching time of 8 ms.Sensors and Actuators A Physical 02/2007; · 1.94 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: This paper presents an interferometric method for measuring the dry/wet mass of a single living cell using an optofluidic chip. It consists of the fiber Mach-Zehnder interferometer and the fiber-optical trap, both of which are integrated onto a single chip. In experiment, a single living cell is captured by the fiber-optical trap, and then the cell's refractive index and diameter are simultaneously determined by the spectral shift in response to the buffer modulation. Hence, both cell dry and water masses can be calculated with a precision higher than 5%.Applied Physics Letters 01/2007; 91. · 3.52 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: This paper reports a novel method for measuring the effective refractive index (RI) of single living cell with a small integrated chip. This microchip is able to determine the RI of living cell in real time without extra requirements of fluorescence labeling and chemical treatments, offering low cost and high accuracy meanwhile. It might provide an efficient approach for diseases or cancer diagnosis. The measurement system integrates laser diode, microlenses, and microfluidic channels onto a monolithic chip. In the experiments, two standard polystyrene beads with nominal RIs are, employed to calibrate the system and five types of cancerous cells are subsequently measured. The results indicate that the RI of the tested cells ranges from 1.392 to 1.401, which is larger than typical value 1.35-1.37 for normal cells.Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. The 13th International Conference on; 07/2005 -
Conference Paper: A self-contained microfluidic cell sorting system for HIV diagnosis
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ABSTRACT: This paper described a self-contained microfluidic system that is capable of monitoring the progression of the HIV infection by counting and sorting CD4 cells. The system can handle raw blood sample without off-chip sample preparation step and by using laser diode as the light source, the need for big and expensive laser is eliminated. Blood analysis is currently being performed in central labs on expensive, high-maintenance equipment and can be time consuming, whereas our system is portable, low-cost and could be used in each doctor's office, as a point-of-care instrument at home or in places with high risk of exposure to biowarfare agents.Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. The 13th International Conference on; 07/2005 -
Article: MICROFLUIDIC DROPLET-BASED LIQUID-LIQUID EXTRACTION FOR FLUORESCENCE-INDICATED MASS TRANSFER
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ABSTRACT: Figure 1: (a) Schematic of molecule mass transfer across the two immiscible phase boundary. (b) Schematic of the solute extracting (concentration varying) process indicated by droplets at different reaction times. ABSTRACT This paper demonstrated a fluorescence-indicated mass transfer liquid-liquid extraction process based on a droplet microfluidic system. Analysis of the droplet-based liquid-liquid extraction process based on the description of mass transfer into or out of droplets is conducted. The relationship between the extraction efficiency and the droplet size is measured and the mass transfer coefficient for fluorescein from octanol to PBS buffer is determined as 3.07 × 10 -5 m/s. This work has wide potential applications in extraction system design and other chemical-biological areas. - [Show abstract] [Hide abstract]
ABSTRACT: This UROP project aims to do a feasibility study on electronic properties of DNA especially on Metallic DNA (M-DNA). We are trying to prove the conductivity of M-DNA. This document begins with a general introduction of electronic properties of DNA and M-DNA. The experiment set up and results will also be covered in later part. Finally, a short discussion based on the experiment results with respect to the results. - [Show abstract] [Hide abstract]
ABSTRACT: This paper presents an integrated and self-contained microfluidic system for monitoring the progression of the HIV infection by counting and sorting CD4 cells. The system can handle raw blood samples without the need of off-chip sample preparation. In addition, the system has integrated a laser diode onto the microchip as the light source, making it more compact and portable. Compared with the current blood analysis method performed in central laboratories, our system is low cost, portable and low requirement for maintenance, and thus could be used for point-of-care diagnosis. 1. INTRODUCTION Progression from clinical latency to AIDS in persons with HIV infection is suggested by CD4 lymphocyte counts of less than 500 cells per ml. Blood analysis is currently being performed in central labs on expensive, high-maintenance equipment and can be time consuming. Therefore there is a need for portable, fast and easy-to-operate cytometer system for small clinics or ever household use. Kruger et al. demonstrated a miniaturized flow cytometer which can perform the key functions of detection, enumeration and sorting of fluorescent species [1]. Dittrich et al. reported a microfluidic device for reaction, high-sensitivity detection and sorting of fluorescent cells and particles [2]. But for all these miniaturized flow cytometers, blood samples need to be pre-processed before they can be put into the chip. And another problem is that external laser has to be used as the light source for optical detection, which results in the difficulty of integration. We proposed a self-contained microfluidic system fabricated in poly (dimethyl siloxane) (PDMS) to monitor the progression of the HIV infection. Reagents will be preloaded in the respective reservoirs such that the system can handle the raw blood sample without any off-chip sample preparation step. Laser diode will be integrated in the chip as the light source, which eliminates the need for bulky and expensive laser system and makes the optical system more compact. - [Show abstract] [Hide abstract]
ABSTRACT: This paper proposes a novel, non-invasive and reliable method for cell identification based on MEMS laser spectroscopy and microfluidic chip. This system integrates micro flow and micro-optics into one chip to realize cell identification and manipulation. An argon laser at 488 nm passing through a microlens array was used to excite a fluorescence-labeled cells suspended in solution. The microlens array serves the function to focus the laser to the desired spot size and also to reduce the scattering in the channel sidewall. A spectrometer is used for detecting the fluorescence spectrum and identifying the cells. The device was calibrated by use of polystyrene micro beads and tested on HeLa cells. As expected, different cells are identified according to their specific fluorescence spectra. This identification system might provide a valuable tool for cell studying and cancer diagnosis such as leukemia, AIDS and so on. - [Show abstract] [Hide abstract]
ABSTRACT: Isolation and purification of cell subpopulations are of great importance to cell biology and molecular genetics. This paper presents an integrated microfluidic device for fluorescence activated cell sorting based on the indirect manipulation of cells by precisely steering the liquid flow. Unlike conventional pressure-driven system, this microfluidic device exploits electroosmotic flow for sample transportation, focusing and switching. Electroosmotic manipulation on-chip eliminates the need for external syringe pump and provides faster and accurate switching and consequently, higher throughput.
Publication Stats
93 | Citations | |
22.57 | Total Impact Points | |
Top Journals
Nanyang Technological University
- School of Electrical and Electronic Engineering
Singapore, Singapore


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Nike LeBron 10 "Kay Yow" PE on eBay by Patrick Johnson 0 Comments
October 9, 2012 BY Brendan Dunne / 21
There are a couple of Christmas-time traditions that have become pretty reliable in the sneaker world, your yearly Air Jordan XI drop, the blogs running down the top releases from the year, and Nike Basketball cranking out a couple of special colorways to celebrate the holidays. Looks like all three of those will be on tap again for this year, the last of which arriving on the Nike LeBron X on this red and green pair. The release looks to be one of the non-Nike+ enabled pairs, making it that much easier on the pocketbook of whoever you'll be begging for them come December. Click through to check out the Nike LeBron X 'Christmas' and stick with Sneaker News for release info.
Photos: Marquee Sole
Filed under: Basketball LeBron Upcoming Sneakers
Nike LeBron 10 "Kay Yow" PE on eBay by Patrick Johnson 0 Comments
NBA Feet: Around The League – 11/05 – 11/06 by Patrick Johnson 3 Comments
Nike LeBron X "Shattered Prism" Customs by ROM by Brendan Dunne 3 Comments

subset: commoncrawl


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You're Not You TrailerYear 2014 | Genre Dramas Synopsis - When Kate (Hillary Swank), a concert pianist, is diagnosed with ALS (also known as Motor Neurone Disease or Lou Gehrig's Disease), she realsised that not only does she have to... Directed by George C. Wolfe Starring Hilary Swank, Josh Duhamel, Emmy Rossum, Ali Larter, Marcia Gay Harden, Julian McMahon, Jason Ritter, Stephanie Beatriz, Frances Fisher, Ernie Hudson, Loretta Devine, Mike Doyle, Andrea Savage, Beau Knapp, Gareth Williams, Gerald Downey, Rebecca Rowley, Sahra Mellesse, David Grant Wright, Erin Chenoweth, Katharine Lee McEwan |
Scenic Route - TrailerYear 2014 | Genre Dramas Synopsis - Mitchell seemed to have the perfect life with a beautiful wife, a family, nice house and a successful career. However, he finds himself missing old times from his youth and... Directed by Michael Goetz, Kevin Goetz Starring Josh Duhamel, Dan Fogler, Peter Michael Goetz, Miracle Laurie, Christie Burson, Jamie Donovan, Ethan Maher |
Fire With Fire TrailerYear 2013 | Genres Action, Adventure Synopsis - Jeremy Coleman is a firefighter who is looking forward to a night of celebrations with his workmates after a particularly taxing day on the job. However, as he stops by... Directed by David Barrett Starring Josh Duhamel, Bruce Willis, Rosario Dawson, Vincent D'Onofrio, 50 Cent, Julian McMahon, Vinnie Jones, Arie Verveen, Eric Winter, Bonnie Somerville, Richard Schiff, Yohance Myles, James Lesure, Quinton 'Rampage' Jackson, Kevin Dunn |
Safe Haven TrailerYear 2013 | Genre Alternative Synopsis - When Katie Feldman flees from her city and winds up in the picturesque town of Southport in North Carolina, she is initially welcomed by the close-knit community. As much as... Directed by Lasse Hallstrom Starring Josh Duhamel, Julianne Hough, Cobie Smulders, David Lyons, Noah Lomax, Mimi Kirkland, Mike Pniewski, Lauren York, Cullen Moss, Ric Reitz, Jasper Grey, Laura Avnaim, Robin Mullins |
New Year's Eve, Teaser TrailerYear 2011 | Genre Romance Synopsis - On New Year's Eve, there is no better place to be than New York. All over the city, thousands are preparing for the most magical night of the year. One... Starring Robert De Niro, Ashton Kutcher, Katherine Heigl, Sara Paxton, Carla Gugino, Sarah Jessica Parker, Abigail Breslin, Jessica Biel, Sofia Vergara, Josh Duhamel, Zac Efron, Michelle Pfeiffer, Alyssa Milano, Lea Michele, Hilary Swank, Halle Berry, Sienna Miller, John Lithgow, Julie Andrews, Jon Bon Jovi, Ryan Seacrest |
Transformers 3: Dark Of The Moon, Teaser TrailerYear 2011 | Genres Action, Adventure Synopsis - When man first landed on the moon over 40 years ago, their journey was well documented and broadcast on the TV around the world, what we weren't to know was... Directed by Michael Bay Starring Shia LaBeouf, Rosie Huntington-Whiteley, Josh Duhamel, Tyrese Gibson, Ramon Rodriguez, Hugo Weaving, Peter Cullen, Patrick Dempsey, John Turturro, Frances McDormand, John Malkovich, Lester Speight, James Avery, Mark Ryan, Ken Jeong, Alan Tudyk, Frank Welker, Kevin Dunn, Glenn Morshower, Kym Whitley, Karyn Parsons, Julie White, Corey Burton, Jess Harnell |
Ramona And Beezus, TrailerYear 2010 | Genres Kids, Family Synopsis - The day to day adventures of Ramona and her big sister Beezus are well known. The hugely popular childrens books written by Beverly Cleary have been turned into a film... Directed by Elizabeth Allen Starring Selena Gomez, Joey King, John Corbett, Bridget Moynahan, Ginnifer Goodwin, Josh Duhamel, Sandra Oh, Jason Spevack |
Life As We Know It, TrailerYear 2010 | Genre Comedies Synopsis - Being named a godparent is truly a remarkable thing, when Holly and Eric are named the godparents of their best friends daughter, they are more than happy to accept, though... Directed by Greg Berlanti Starring Katherine Heigl, Josh Duhamel, Josh Lucas, Christina Hendricks, Jean Smart |
The Romantics, TrailerYear 2010 | Genre Romance Synopsis - Lila and Laura were best friends through college, they were always close and their extended set of friends were almost as close as they were. Named 'The Romantics' by other... Directed by Galt Niederhoffer Starring Katie Holmes, Josh Duhamel, Anna Paquin, Elijah Wood, Malin Akerman, Adam Brody, Jeremy Strong, Rebecca Lawrence, Dianna Agron, Candice Bergen |
When In Rome, TrailerYear 2010 | Genre Comedies Synopsis - When Beth attends her sisters sporadic wedding in Rome, she expects to fulfil her duties as maid of honour and return to her job focused life in New York. Sick... Directed by Mark Steven Johnson Starring Kristen Bell, Josh Duhamel, Will Arnett, Jon Heder, Dax Shepard, Danny Devito, Anjelica Huston, Alexis Dziena, Don Johnson, Bobby Moynihan, Lee Pace |
Transformers: Revenge Of The Fallen, TrailerSynopsis - Watch the trailer for Transformers: Revenge of the Fallen.Revenge of the Fallen is the title of the second Transformers movie! Once again we join Sam Witwicky and his fight with... Starring Megan Fox, Shia LaBeouf, Rainn Wilson, John Turturro, Isabel Lucas, Josh Duhamel, Tyrese Gibson, Matthew Marsden, Samantha Smith, Kevin Dunn, Peter Cullen |


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Giant Interactive Group Management Discusses Q3 2011 Results - Earnings Call Transcript
Before we continue, I would like to remind you that statements on this call that are not strictly historically in nature constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 as amended and Section 21E of the Securities Exchange Act of 1934 as amended and as defined in the Private Securities Litigation Reform Act of 1995.
These forward-looking statements can be identified by terminologies such as will, expects, anticipates, future, intend, plans, beliefs, estimates and other statements, and include among others, statements regarding our 's expectation of sequential top line growth in the fourth quarter of 2011 future prospects of the company and the Chinese online game industry, future financial position of the company, the ability for the company's new web game projects to diversify its user base. The investment strategy of the company and the timetable of – for engineering testing, close beta testing, open beta testing, introduction and commercial launch of the various (inaudible) game pipeline.
Such forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results of Giant to be materially different from historical results or from any results expressed or implied by such forward-looking statements.
These factors include, but are not limited to, the deterioration in the performance of the ZT Online 1 Series, failure of ZT Online 2 to grow as expected, unexpected delays in developing expansion packs or in the timetable for testing, introduction and launching of games, the company's dependence on the ZT Online 1 Series games, which currently account for the majority of the company's historical net revenues.
The company's limited operating history and unproven long-term potential of its online game business model. The uncertainties with respect to the PRC legal and regulatory environments and the volatility of the markets in which the company operates. Competition from other online game companies, and the additional risks discussed in filings with the Securities and Exchange Commission, including our annual report on Form 20-F filed on June 17, 2011.Check Out Our Best Services for Investors
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May I ask you a personal question? Do your breasts hurt?
If you answered "yes," you are not alone. According to research, many women feel discomfort in their breasts at some point or another. For many of us, this pain will come around menstruation, when breasts tend to be bigger and more sensitive anyway. But for other women, these uncomfortable feelings just don't want to go away.
Since I asked the personal question it's only fair that I answer it too so here goes—yes, they sure can and do! And I have a young son who loves to crawl up on my lap and too often I have to sort of move to one side to make sure he's not bumping up too hard against "the girls".
Not too long ago, I got to thinking about the situation and why breasts can so often get sore and painful for so many women, myself included. It struck me how when I was pregnant, rather than have the increased sensitivity and pain that so many women report during this time, mine actually felt better. Then I got to thinking—what, besides the pregnancy itself, was different during those two times I was expecting? And before long it hit me—in both pregnancies I almost completely eliminated caffeine.
This epiphany got me to thinking even more, and then it got me doing research. What I realized is that now that I'm a busy mom of two boys who works from home and tries to keep an average of about 25 plates in the air at all times, I have upped my caffeine intake more than ever. Just ask the friendly baristas at my neighborhood Starbucks—they'll tell you. I love my caffeine and I have two big doses of it a day—at home in the morning, and at Starbucks literally every afternoon.
So could this increase in my beloved coffee be the reason for my sensitive girls? I got on the computer and did some research, and lo and behold, there is a direct connection between caffeine and breast tenderness.
For example, in a study conducted by researchers at Duke University Medical Center in Durham, North Carolina, 61 percent of women with breast pain had a reduction in breast tenderness when they cut out caffeine.
It's not the caffeine. It must be something else in the coffee. I switched to decaf more than a year ago and have been drinking "instant" for the convenience. And I've been fine. Then on a whim, two weeks ago, I started drinking ground decaf French roast. OMG, the pain! Either the stuff was mislabeled as decaf or it's something else in the coffee that does it.
February 26, 2015 - 8:43amSince my forties, I have been experiencing lumpy painful breasts 2 weeks before my period that lasts until after my period is over. I have been a coffee drinker for 25 years so when my doctor suggested quitting, I ignored her advice. Recently, I had to quit drinking coffee due to stomach pain. I cannot believe the difference it has made with my breast pain and lumpiness. It has vanished! I am 1 week away from my period and I have absolutely no pain or lumpiness. It was really hard to give up coffee. I swore I never would but now, I am so glad I did. The stomach pain has subsided, too!
January 25, 2015 - 6:51amI am experiencing breast pain - pretty chronic - both breasts and when I went to the doctor she said I have a lot of new cysts - clusters even. She mentioned that I should cut out barista coffee - she said that I could still have caffeine from instant coffee and that I could drink tea. It's only been three days and I am in more pain than when I went to see her. I have had a green tea or two and still eating chocolate so perhaps it's time to say goodbye to those too from the comments I've read here.
January 5, 2015 - 6:02pmI only have pain on my left breast, but when I don't have caffeine, I am pain free. So I now drink decaf, and have finally found a good full bodied brand, that is also organic.... I get the K-Cups and use the second to largest cup size, so its stronger... if anyone is looking, its called Gorilla organic .... LOVE IT! I get it at Acme and Shop rite....
December 13, 2014 - 7:21pmI was wondering if decaf would work, because it still has a little caffeine?
February 24, 2015 - 9:38amCoffee gave me breast lumps. I tried many doctors and no one could find anything. They told me the burning should go away but the lump was growing and the pain was getting worst. I had a good diet. So one day I cut my coffee from the root. My friend told me, it's the coffee. 2 weeks later the pain was almost gone, 2 months later the 'lime size' lumps dissolved. Today. After a year without caffeine, I craved coffee, I had it, an u feel a bad burn again on my breast. I must be too sensitive but I must say goodbye to coffee once and for all :((
November 19, 2014 - 3:12pmHi Alison,
I'm so glad you wrote this article because I have been experiencing similar pain and had no idea why. At a young age of 22 (and never pregnant) my mind went immediately to breast cancer (it doesn't help that October is breast cancer awareness month so it's already on my mind). I went to the doctor yesterday and he said that it could be due to the caffeine and chocolate that I consume on a daily basis. The only thing I found to be weird is that it's only one breast, instead of both. It has also noticeably increased in size recently in addition to the pain that I've had for a while, which made me wonder a bit. Have you noticed that too at all? I'm getting an ultrasound in a week so at least I'll get confirmation then but I'm still worried because it just seems so weird. Who would've thought that caffeine would have such a strange side effect?!
October 24, 2014 - 7:45amI'm menopausal and on HRT. I used to get breast tenderness all the time. I cut down my coffee because I have an anxiety disorder and I finally decided to stop pretending coffee wasn't making it worse. I gave up filter coffee altogether, and now have one cup of instant cappucino a day (withdrawal was pretty bad for a a few weeks - headache, sleeplessness, irritability). But I feel better for cutting down. And the breast tenderness has absolutely vanished. I didn't cut down caffeine for that reason, but it was a very welcome side-effect.
April 2, 2013 - 3:19pmThis is interesting...I've seen a lot of discussion of different risks and drawbacks associated with heavy caffeine use. I am male (and thus obviously not pregnant), so I can't comment about breast pain, but I have noticed that in general, on days in which I drink large amounts of caffeine, I notice aches and pains all throughout my body a lot more than I normally would. It is well-known that high doses of caffeine can greatly increase stress, and stress is not only universally hard on the body, but it also can make us feel pain and other uncomfortable sensations more intensely.
Do you have a link to the original study that this article was written about? I looked in google scholar and found a number of different articles relating to this topic, but most of them were substantially older than this article. At RateTea.net, we have been working on an article on tea and pregnancy, and this might be a relevant issue to add there if there are any solid studies on it. Women interested in reducing their caffeine intake during pregnancy might also want to read that article.
It is worth mentioning, for people who do feel a need for some sort of caffeine throughout the day, that tea offers a good low-caffeine alternative to coffee. The current scientific consensus, as we discuss in our article, and as is mentioned here in this article here on empowher, is that moderate (<200mg / day) caffeine intake during pregnancy is completely safe. Two cups of strong coffee can place you over this limit, but three or more cups of tea is safe, unless the tea is brewed exceptionally strongly. Also important, tea has also been shown to boost alertness equally well will coffee, even though it contains caffeine, because it also contains other alertness-boosting substances. See this study for more info about that.
I think the important thing here though is to practice moderation. An excess of anything is going to be unhealthy, whether you are pregnant or not. If you live a balanced lifestyle, without excess of caffeine or anything else, you have nothing to worry about!
August 3, 2010 - 11:38amHi! Thank you for your comment! I did see a decrease in pain from cutting back on caffeine. I confess that I'm drinking more caffeine again but my experiment did work. It's definitely worth a try I think--if it works for you too will you please let me know? thanks for reading the article!
July 14, 2010 - 10:20pm


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Little Fighter Alpha
Created with Little Fighter game sprites, this series is like a hardcore in-game cinema.
"Theres Something About Halo 2"
TSAH2 is finally here! (we're sorry about all the delays)
5 talented artists join forces to bring you this action packed Halo cartoon.
Lots of info inside the movie. Have a good look around the menus when its loaded.
Special Thanks to Tom Fulp for the support.
Visit www.SuperFlashBros.net for some extras!
Special Thanks to Melina for helping Headshot sketch Cortana!
Special Thanks to Dustin for helping Joey!
This is great! my favorite part is where Neo is still falling through space, GENIUS! I wasn't going to write a review till I saw that part. it was just too good not to write a review. lol, I LOVE IT! All your stuff is genius, great job LF!
If only I could review one scene of this flash.
I only liked "Return to sender" out of them all, it was disapointing really as it was not nearly as funny as TSAH, meh, this review only counts for Return To Sender.
Teh Awesomeness!
Once again you made an incredible spoof for Halo! =D Well done!!


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37 results total, viewing 21 - 30
Parents, grandparents or guardians can be helpful in assisting with a child's education. They can attend parent-teacher conferences and open houses to ask questions about coursework or projects and volunteer in the classroom during different activities.
| 8/21/14 | 2179 views |
From the grandiose, dramatic title, I'm sure you correctly assumed this column would be about fantasy football.
Posted by Tim Barnum | email@example.com |
Oh, the terrible twos. Everyone talks about them. You hear all kinds of horror stories about them. And right now, my wife, Kay, and I are living through them with our twin boys, Ethan and Ryan.
And to be honest, they're not all that terrible.
Posted by Eric Young | email@example.com |
Many people often view primary elections as a waste of time, due to the fact that they do not feel they should be limited to voting for just one political party. Their complaints are not baseless, but that is not a reason to skip the primary election Aug. 5.
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By the end of this calendar year, there should be a new Deep River Township Hall, and we believe it will be a facility the township can be proud of.
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What anniversaries are considered "noteworthy" — one year? Five years? 12 years? 30 years?
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As summer finally has made its way into the area, orange cones are popping up along local roads and highways, signaling the start of road construction in Michigan.
During this hectic season, for …
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America is no longer the top dog in many areas it was once dominant in due to a long, lingering recession, the emergence of other countries around the globe and other factors, but there is one list the U.S. continues to top easily.
| 6/4/14 | 1231 views |
This Saturday is the Drug Enforcement Agency's National Drug Take-Back Day, and it's the perfect opportunity for people to get rid of old prescription pills, which, according to Det. Lt. Jeff Keister, with STING, have become the new gateway drugs.
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Connect with vegetarian and vegan friends from all over the world.
Being a vegetarian is great, but GMO's are on the rise! Stop GMO's. Stop Monsanto! Label our foods!
Members: 24
Latest Activity: Jul 16, 2014
Started by Amanda Kimbell. Last reply by Amanda Kimbell Sep 21, 2013. 4 Replies 0 Likes
Top 10 gmo foods!1. Soy 90 %2. Corn3. Canola oil4. Cotton5. Milk6. Sugar7. Aspartame8. zucchini9. Yellow squash10. PapayaContinue
Started by Amanda Kimbell Aug 23, 2013. 0 Replies 1 Like
Genetically modified foods are the combination of two different kindoms! The DNA of bacteria and for instance the corn crop. This enables the crop to grow with pesticides internally! These cancer…Continue
Watch this video for more information of how GMO foods alter organ function! http://youtu.be/T-IJikX1144
That's great! I only just started researching gmo's about a month ago because i was wondering what all the hype was about, and i didn't understand why they were dangerous. I learned that pesticides grow within the crop itself due to the bacteria DNA being genetically combined with the crop! Scary stuff. I have many great videos to share
What about anti-monsanto campaign all around the world to be organized next week, lets unite together to close down Monsanto other gmo factories.
We organized a march against monsato in 12th October in Chitwan, Nepal.
That's beautiful! congrats!
I wish products were labeled where i live, the best thing i can do is research the brand if i end up buying in a grocery store, but most of all i grow my own garden and it certainly looks and tastes better. GMO's are truly frightening for health, the environment, society, basically just life itself.
Hey everyone GMO's cause many health problems including infertility, allergies and cancer! Spread the word!
March 25, 2015 from 7pm to 9:15pm – Millman Street Community Rooms, Millman Street, WC1 (access is via doored passageway which is between 34 and 38a Millman Street. Press button marked "Community Centre" on panel next to passageway door entrance ).
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darius is op.
Junior Member
Absolutely not, Darius is under powered, Evelynn and even Shaco beat him 1v1. I wish Riot would buff him. /sarcasm
cho'gath counters him pretty well with his aoe knockup and the silence screws darius up because its range is bigger than the apprehend (going off wikia values) and without apprehend darius has no ridiculous instakill combo, another counter for him is blitzcrank with the bigger apprehend, knock up and the silence
Zephyr Arcturus
1. Face Darius as Ahri or an AP assasin 2. Keep a safe distance away 3. Use foxfire and orb of deception and maybe even ignite. 4. ???? 5. PROFIT! Since most Darius' don't really like to build magic resistance (from what I've seen anyway), if you have some AP champions that love to do burst magic damage, killing Darius won't be hard, especially if you have good CC abilities :3
How is a true damage ult that does 1.2k not OP?
II Cloud 9 II
Darius is not OP, period. Learn to play scrubs, he is easy to counter and any ranged champs can poke him into oblivion. /thread
Fidlesticks can destroy a Darius ever since lv 2 , using fear and the life drain skill. A good ap Master yi would never get touched by darius Tristana's E skill even if AD tristana at first levels can destroy him. Nidalee , needless to explain and there's a lot more champions who can kill a darius until he Alt+F4 not op i say.
Carpe Vinum
Senior Member
an N M E
A true damage execute that resets is a little ridiculous, but if you know how to play against his weaknesses, he isn't too difficult to shut down.


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38 year old man | San Francisco, CA, USA | Seeking women 25-35 within 50 miles
Active within 24 hours
I mix it up pretty well between friends,...
I mix it up pretty well between friends, family, career and enjoying life. I grew up on the North Shore, youngest of seven and a former athlete at Arizona State. I live a fun life leading adventure tours around the world and working in sports production for the San Francisco Giants and 49'ers. When I'm not working, you can usually find me kitesurfing, doing remodeling projects or enjoying good times with friends and family. I look forward to hearing from you…Aloha!
Dining out , Playing sports , Travel/Sightseeing
Other types of exercise, Yoga
I exercise 3-4 times per week.
Middle of the Road
The Southern Islands in Thailand, Wilbur Hot Springs, San Felipe Mexico, Kaaawa Valley, La Jolla, Sedona, Costa Rica, Yosemite, Mo'orea Tahitii, Napa and more to come!
Arizona State University, Tempe, AZ
A good margarita, Mexican food and being on a plane ready for take off
Kitesurfing, riding motorcycles, remodeling projects and adventure travel
3 Cups of Tea, Shadow Divers, American Sniper, Unbreakable
Him | What he is looking for | |
Appearance | ||
Height: | 5'10" (177cms) | 5'4" (162cms) to 5'11" (180cms) |
Body type: | Athletic and toned | Slender, Athletic and toned |
Eyes: | Brown | No preference |
Hair: | Dark brown | No preference |
Lifestyle | ||
Smoke: | No Way | No Way |
Drink: | Social Drinker | Social Drinker |
Occupation: | Sales / Marketing | No preference |
Income: | $100,001 to $150,000 | $50,001 to $75,000, $75,001 to $100,000, $100,001 to $150,000, $150,001+ |
Relationship: | Never Married | No preference |
Have kids: | No | No preference |
Wants kids: | Someday | Definitely, Someday |
Background | ||
Ethnicity: | Asian, Pacific Islander, White / Caucasian | No preference |
Faith: | Spiritual but not religious | No preference |
Languages: | English | English |
Education: | Bachelors degree | Some college, Bachelors degree, Graduate degree, PhD / Post Doctoral |


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In ConocoPhillips Canada Resources Corp. v. The Queen (2014 FCA 297), the Federal Court of Appeal overturned a Federal Court decision (2013 FC 1192) and dismissed an application for judicial review by the taxpayer finding...more
1/15/2015 - Canada ConocoPhillips Corporate Taxes Financial Conduct Authority Jurisdiction
In Brent Kern Family Trust v. The Queen (2014 FCA 230), the Federal Court of Appeal dismissed the taxpayer's appeal with reasons delivered from the bench. The taxpayer had argued that the decision of Canada v. Sommerer (2012...more
11/18/2014 - Canada Tax Court Trusts
In Bolton Steel Tube Co. Ltd. v. The Queen (2014 TCC 94), the Tax Court of Canada allowed the taxpayer's motion requesting an Order that would require the CRA to reassess the taxpayer in accordance with the terms of a...more
6/27/2014 - Canada Corporate Taxes CRA Settlement Tax Court
When are the parties to a civil tax dispute bound by agreed facts from a criminal proceeding? This was the question considered by the Tax Court of Canada on a Rule 58 motion made by the taxpayers in McIntrye et al v....more
4/18/2014 - Canada Collateral Estoppel Income Taxes Res Judicata Tax Liability
The Supreme Court of Canada has granted leave to appeal in Guindon v. The Queen (Docket # 35519). In this case, the Supreme Court of Canada will consider whether penalties imposed under section 163.2 of the Income Tax Act...more
3/24/2014 - Appeals Canada Income Tax Act Income Taxes SCC
In Morton v. The Queen (2014 TCC 72), the Tax Court of Canada upheld penalties imposed by the Minister of National Revenue (the "Minister") under subsection 163(2) of the Income Tax Act (Canada) (the "Act"") despite novel...more
3/20/2014 - Canada False Statements Income Taxes Penalties
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text:
Blue Martini Leaps on Product Deployment
The companies named private department store chain Belk, Canadian Tire, The Limited, Gymboree, Mountain Equipment Co-op and Saks Fifth Avenue as customers.
The Java-based technology allows integration of information from marketing, commerce, channel management and service, the companies said.
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text:
Leaving The Law: A Risky Career Change Toward Passion
I didn't have the skills to do anything but litigate, and certainly not the résumé. As much as I didn't want to be a lawyer again, I had focused on it for so long that I just couldn't see myself any other way. The first day after leaving I sat down to make a list of other possible career fields. I came up with business, banking and insurance. Journalist and travel writer certainly never made the list.
According to Lansky people decide to leave careers at different times and for different reasons, but one thing that should never hold you back is the idea that you've already got too much invested in to turn around.
"There's an expression in finance, throwing good money after bad," she said. "You don't want to tie yourself to a career that makes you unhappy just because you spent money on it at one point... Sooner or later it's going to hit you right between the eyes."
For me that was absolutely true. Although I had sunk nearly a third of my life into getting there, leaving the law was absolutely the right decision. As career moves go, leaving a good job in a prestigious field was probably a lousy one, but my motives weren't based around a five year plan. They were much more simple than that. I had been unhappy for a long time and that needed to change.
So I left. My fiancée and I bought a pair one way tickets to Cambodia and decided it was time to see the world for a while. I started my website along the way and fell into being a writer. On a good day, I make a quarter of what I used to and have absolutely none of the perks that came with a top floor view. I can't use the old instruction manual anymore, the one I followed from high school to college to law school to the firm. Life has gotten more complicated than that, but I wouldn't have it any other way. Besides, I'm already down ten pounds.Check Out Our Best Services for Investors
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text:
I have some problem with my singleton and UIViewController there;
@property (nonatomic, retain) UIViewController *viewController;
@synthesize viewController = _viewController;
- (void)load {
self.viewController = [[[UIViewController alloc] initWithNibName:@"NibName" bundle: nil] autorelease];
- (void)unload {
[_viewController release];
This viewController
using by different part of the application via pushViewController:animated:
. But sometimes I need to release viewController
by calling method - (void)unload
of Singleton class! If pushViewController:animated:
never call for viewController
everything is well and dealloc is calling, but if pushViewController(and viewController perform viewDidLoad), dealloc isn't work. If I do something like self.viewController = nil;
dealloc calling twice... What I'm doing wrong???


text:
Man arrested for allegedly attacking and molesting at least one woman
Published on Mar 21, 2014 1:52 PM
The police arrested a 22-year-old man on Thursday afternoon in a case of aggravated outrage of modesty along West Coast Road.
The victim, a 25-year-old woman, was attacked on Monday, along the Ayer Rajah Expressway near to West Coast Way, while she was walking back to her home, a condominium apartment.
The suspect, who is unemployed, was cycling on a stolen bicycle along the same path when he attacked her.
He reportedly got off the bicycle and punched her. When she fell, he pinned her to the ground and started to grope her. He ran off as two passers-by approached, leaving behind the bicycle.
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Pronunciation: /ˈherəˌwizəm/
Definition of heroism in English:
Great bravery.
Example sentences
- The heroism of the police is recognized by the coalition in medal ceremonies like this.
- The story contrasts Asian and western concepts relating suicide and heroism.
- There were periods of real heroism as Scotland tried to speed the game up, Gordon Simpson deciding to run a quick one at the outset.
bravery, courage, valor, intrepidity, boldness, daring, audacity, fearlessness, dauntlessness, pluck, stout-heartedness, lionheartedness;
Definition of heroism in:
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text:
Not many artists can say they've decorated a 10-foot fiberglass guitar.
With the GuitarTown project returning to Waukesha in 2013, artists have the opportunity to take on the challenge of painting a 10-foot Gibson Les Paul guitar or a regular-sized.
In order to be considered for this project artists must submit all materials by 5 p.m. Thursday.
All applicants must be at least 18 years old and a Wisconsin resident.
Applications will be processed by a selection committee and artists will be reviewed and selected based on their proposal, work examples and résumé.
Any artist selected toprovide artwork will be required to execute a contract for services approved by the selection committee, the Waukesha GuitarTown website notes.
Artists are asked to submit contact information, four photos (4-inch by 6-inch) of current artwork clearly labeled, a detailed concept proposal with both visual (minimum front and back) and a written description of the concept (only original materials will be accepted), a self-addressed, postage paid mailer if you want application materials returned (all application materials from selected artists will be retained by the selection committee until the project is completed).
The Waukesha GuitarTown website instructs individuals to send or deliver all materials to the AlmontGallery with the label, Waukesha West End Artists, 342 W. Main St.,Waukesha, WI 53186.
The GuitarTown project is a way to celebrate the contributions of Les Paul, a music icon who was born and is buried in Waukesha.
The project's goal, through its sponsorships, also raises money for the community. Last year $105,000 was raised: $45,000 to the Waukesha Public School District for new musical instruments and art supplies; $45,000 to the Les Paul exhibit at the Waukesha County Museum; $15,000 to the Waukesha Memorial Hospital to help fund the new Community Health Clinic.
For questions on GuitarTown artists, contact Waukesha GuitarTown Steering Committee member Lynn Gaffey at (262) 542-1522 or firstname.lastname@example.com. For more details, visit waukeshaguitartown.com.
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- Publisher: Larian Studios
- Release Date: Aug 6, 2013
- Critic Score
- Most active
- Publication
- Most clicked
Sep 9, 2013Complicated, difficult, different. A true strategy game for the gamers with classical tastes, who have time and will. It's also a pleasant blast from the past, when a genre template was not an option. [Issue#233]
Aug 28, 2013A surprise of the year? Definitely! Dragon Commander is a big entertaining game, proving above all that more the genres you mix it does not necessarily mean more the risk and pain. The dragon soup is a gastronomic hit of the summer.
Aug 6, 2013Divinity: Dragon Commander is an excellently written and polished blend of action, RPG, and strategy that delivers on each front without feeling disjointed or glaringly weak in any one area. It's a game in which each component meshes together well as a whole package, and the end result is a fantastic genre mixing title that is both entertaining and thoughtfully constructed.
User score distribution:
Positive: 27 out of 53
Mixed: 9 out of 53
Negative: 17 out of 53
Aug 6, 2013
Aug 6, 2013
Aug 8, 2013


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text:
The Government is celebrating after the High Court threw out a challenge to its cigarette plain packaging laws, but legal experts are warning there may still be international challenges....Wednesday 15 August 2012
The Rural Doctors Association is urging the Federal Opposition to support the legislation for plain cigarette packaging....Friday 27 May 2011
The ACT Greens have been accused of gross hypocrisy over a proposal to ban Government investment in a range of industries including liquor, tobacco and coal mining. ...Tuesday 21 September 2010
Explore by Topic
Latest Tobacco stories on ABC Canberra
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The West Australian Opera says it's decided not to mount a production of 'Carmen' while it's being sponsored by a health promotion agency. The beloved opera is set around a cigar factory. Opera WA says it wasn't pressured into making the decision, and that the sponsorship deal was just one factor in ...Wednesday 8 October 2014
E-cigarettes are a medicine designed to reduce the harm of smoking according to documents 7.30 has obtained from a British American Tobacco company's submission to the Therapeutic Goods Association, but health experts dispute that claim....Thursday 2 October 2014
The Chinese capital of Beijing is considering strengthening a ban on indoor smoking next year. The city will serve as a model for the rest of the country if successful. However, the efforts of anti-tobacco advocates are being undermined by a conflict of interest in the tobacco industry. ...Monday 15 September 2014
The World Health Organisation has called for e-cigarettes to be regulated like tobacco...Wednesday 27 August 2014
- E-cigarettes deliver a nicotine hit via an inhaler, minus the tobacco, which has prompted some to claim they're better for your health. However, a World Health Organisation report released this week has called for global restrictions on their sale and marketing. In some respects, this is a mute ...Wednesday 27 August 2014


text:
Relationship between age, renal function and bone mineral density in the US population
- Sidney Klawansky,
- Eugene Komaroff,
- Paul F. Cavanaugh Jr,
- David Y. Mitchell,
- Matthew J. Gordon,
- Janet E. Connelly,
- Susan D. Ross
- … show all 7 hide
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Bisphosphonate drugs for treating osteoporosis are excreted by the kidney. However, many of the major trials on efficacy and safety of the bisphophonates for treating osteoporosis excluded patients with significant renal compromise. Since both osteoporosis and renal insufficiency become more prevalent with age, it seems prudent for physicians to be aware of the prevalence of renal dysfunction in patients with osteoporosis who are candidates for treatment with bisphosphonates. Data on 13,831 men and women aged 20+ from the Third National Health and Nutrition Examination Survey, 1988–1994 (NHANES III) were used to study the occurrence of compromise in renal clearance function in men and women with osteopenia and osteoporosis. To estimate creatinine clearance (CCr), a measure of renal function, serum creatinine (sCr), weight and age were inserted into the Cockcoft-Gault (C-G) formula. The World Health Organization gender specific bone mineral density (BMD) cut-offs were used to define the populations with osteopenia and osteoporosis. For women ages 20–80+ with osteoporosis, the percent prevalence (95% CI) for mild to moderate compromise of CCr ≤60 ml/min is estimated to be 85% (79%, 91%) and for severe renal compromise of CCr <35 ml/min to be 24% (19%, 29%). In women with osteoporosis and severe compromise, the age specific prevalence is negligible through ages 50–59 and then rises steeply to 54% (46%, 62%) for ages 80+. Similarly, in women with osteopenia and severe renal compromise, the age specific prevalence is also negligible through ages 50–59 and then rises to 37% (28%, 45%) for ages 80+. Lower prevalence estimates hold for men with about 11% of men with osteoporosis having severe renal compromise as compared to 24% for women. These data suggest that there is a substantial prevalence of candidates for treatment of osteoporosis and osteopenia who have significant renal compromise but for whom there is a dearth of clinical trial data on the impact of treatment.
- Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K et al. (1993) Bone density at various sites for prediction of hip fractures. Lancet 341:72–75
- Melton LJ III, Kan SH, Wahner HW, Riggs BL (1988) Lifetime fracture risk: an approach to hip fracture risk assessment based on bone mineral density and age. J Clin Epidemiol 41:985–994
- Melton LJ III, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL (1993) Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8:1227–1233
- Ross PD, Wasnich RD, Davis JW (1990) Fracture prediction models for osteoporosis prevention. Bone 11:327–331
- Looker AN, Johnston CC Jr, Wahner HW, Dunn WL, Calvo MS, Harris TB et al. (1995) Prevalence of low femoral bone density in older US women from NHANES III. J Bone Miner Res 10:796–802
- Looker AN, Orwoll ES, Johnston CC Jr, Lindsay RL, Wahner HW, Dunn WL et al. (1997) Prevalence of low femoral bone density in older US adults from NHANES III. J Bone Miner Res 12:1761–1768
- Jones CA, McQuillan GM, Kusek JW, Eberhardt MS, Herman WH, Coresh J et al. (1998) Serum creatinine levels in the US population: Third National Health and Nutrition Examination Survey. Am J Kid Dis 32:992–999
- National Center for Health Statistics (1994) Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988–1994, Vital Health Stat 1(32). DHHS Publication No. (PHS) 94-1308. NCHS, Hyattsville, Md.
- Mohadjer, L. Montaquila J. Waksberg J, Bell B. James P, Flores-Cervantes I, Montes M (1996) National Health and Nutrition Examination Survey III. Weighting and estimation methodology. Westat Inc., Rockville, Md.
- Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31–41
- Siris E (2000) Alendronate in the treatment of osteoporosis: a review of the clinical trials. J Women's Health Gend Based Med 9:599–606
- Watts NB (1998) Treatment of osteoporosis with bisphosphonates. Endocrinol Metab Clin N Am 27:419–439
- Black DM, Cummings SR, Karpf DB Cauley JA, Thompson DE, Nevitt MC et al. (1996) Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 348:1535–1541
- Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Porras, AG (1993) Clinical pharmacology of alendronate sodium. Osteoporos Int Suppl. 2:S13–16
- Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH et al. (1995) Effects of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:1437–1443
- Schnitzer T, Bone HG, Crepaldi G, Adami S, McClung M, Kiel D et al. (2000) Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Aging Clin Exp Res 12:1–12
- Pols HA, Flesenberg D, Hanley DA, Stepan J, Munoz-Torres M, Wilkin TJ et al. (1999) Multinational, placebo-controlled trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT Study. Fosamax International Trial Study Group. Osteoporos Int 9:461–468 CrossRef
- McClung MR, Geusens P, Miller PD, Zippel H, Bensen WG, Roux C et al. (2001) Effect of risedronate on the risk of hip fracture in elderly women. N Engl J Med 344:333–340 CrossRef
- Mitchell DY, St Peter JV, Pallone KA, Kelly SC, Russell DA, Nesbitt JD, Thompson GA, Powell JH (2000) Effects of renal function on risedronate pharmacokinetics after a single oral dose. Br J Clin Pharmacol 49:215–222 CrossRef
- Yendt ER, Cohanim M, Jarzylo S, Jones G, Rosenberg G (1991) Bone mass is related to creatinine clearance in normal elderly women. J Bone Miner Res 6:1043–1050
- Yendt ER, Cohanim M, Jarzylo S, Jones G, Rosenberg G (1993) Reduced creatinine clearance in primary osteoporosis in women. J Bone Miner Res 8:1045–1052
- Title
- Relationship between age, renal function and bone mineral density in the US population
- Journal
Osteoporosis International
Volume 14, Issue 7 , pp 570-576
- Cover Date
- 2003-07-01
- 10.1007/s00198-003-1435-y
- Print ISSN
- Online ISSN
- 1433-2965
- Publisher
- Springer-Verlag
- Additional Links
- Keywords
- Age
- Bone density
- Creatinine
- Osteopenia
- Osteoporosis
- Renal function
- Industry Sectors
- Authors
- Sidney Klawansky (1) (4)
- Eugene Komaroff (1)
- Paul F. Cavanaugh Jr (2)
- David Y. Mitchell (3) (5)
- Matthew J. Gordon (1)
- Janet E. Connelly (1)
- Susan D. Ross (1)
- Author Affiliations
- 1. MetaWorks Inc., Medford, MA, 02155, USA
- 4. Department of Health Policy and Management, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA
- 2. Procter and Gamble Pharmaceuticals Inc., Mason, OH, 45040, USA
- 3. Procter and Gamble Pharmaceuticals Inc., Mason, OH, 45040, USA
- 5. Pfizer Global Research and Development, Ann Arbor, MI, 48105, USA


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We arrived into the office to a bit of good Friday news this morning…
Axon has been ranked as one of the Northern Tech Awards Top 50 Fastest Growing Companies for 2015.
We knew it was coming, and it's not far off now. Microsoft is ending support for Windows Server 2003 on 14th July this year. This includes all versions and subeditions. Service packs actually stopped in 2010, but in five months time support goes too.
What will this mean? Well if you're still running Server 2003 after 14th July you'll be vulnerable to security flaws. Future attacks won't be patched by Microsoft which will leave holes in your system that could lead to breaches, hacks and cyber attacks.
So what's your plan? It's been predicted that Windows Server 2003 end of life will prove to be a huge cloud catalyst. And we won't argue that cloud is certainly a good way to go for many businesses. Migrating to Microsoft Azure or Office 365 will bring concrete benefits including better performance, business mobility, enterprise class security, increased productivity and agility. If that's the path for your business, you'll need to act now to plan your migration strategy and protect your IT infrastructure.
Have a look here for more information on Microsoft Office 365, and speak to us for help migrating your business to the cloud.
We've put our years of experience and heads full of geeky knowledge to good use, and have put together a comprehensive guide to choosing a server.
The 3 part eGuide on choosing a server looks at
• Processors and ram
• Hard drive size
• How to future proof your server
Our free downloadable eGuide covers everything you need to know about choosing the server that is right for you. No signups necessary, no hoops to jump through, just a practical free guide in handy .pdf format which you can download by clicking on the link below.
Over the past few months we've seen a number of instances of customer DNS records being changed. This is usually as a result of the customer having a new website done. The DNS records are changed in order to move website hosts and often the servers hosting the DNS records are changed at the same time. Unfortunately, we often see changes made to DNS records that affect the ability of domains to receive emails.
To change a website host, the only records that need to be changed are the A records. Making any changes to MS, TXT, SRV or SPF records, especially if Office 365 is the mail server, will result in extensive problems when people try to send emails to your domain.
If you need to make changes to your DNS please talk to us, or your own IT support provider, prior to taking any action. We deal with these records on a regular basis and we can advise which changes need to be made and, more importantly, what records NOT to change.
Don't be the victim of your own DNS disruption.
If you need assistance, then please give us a call on 01625 837800 or contact us here.
The pennies have been counted, and the grand total of our fundraising for 2014 was £875.07.
All the money raised has gone directly to our charity of the year for 2014 – Macclesfield Neonatal Unit and the money will be used towards a high flow oxygen unit.
Lynn McGill, Chairman of East Cheshire NHS Trust said, "We have been honoured to have the incredible support of Axon, who named us their charity of the year 2014. The team's enthusiasm for ECHO has seen them raise an incredible total which will go towards a high flow oxygen unit on the neonatal ward at Macclesfield District General Hospital. This equipment will provide more effective and comfortable breathing support for babies who need it. Thank you Axon – it has been a pleasure to work with you. We wish you great success with your future fundraising."
Huge thanks to everyone that supported and sponsored us.
A good few inches of snow in Macclesfield today. Schools are closing, roads are covered, and several of our team are having to stay at home today. Of course, that doesn't matter to us. Thanks to cloud computing, our staff can be productive from anywhere. But without cloud computing, we'd be losing some serious man hours right now.
Loss of productivity as a result of snow days costs businesses in the UK millions every year. How does it affect your business? If you lose 50% of your staff to snow for the day, how much money do you lose?
Of course it depends on your line of business. If you've got factory or shop floor staff, then of course they can't really be utilised at home. But your office-based staff can continue to work as normal. And with VoIP telephony, your business comms can continue to work effectively as well.
If you're not too sure exactly what cloud is, you can find out more info on our cloud services page. But in a nutshell, you move all of your business data away from your on-site servers and into "the cloud" – so onto your cloud provider's servers – and you access it via an internet connection. It gives flexibility, it saves money, and it helps form part of your business continuity and disaster recovery plan – meaning that if your offices become rendered out of action, for whatever reason, fire, flood, theft, or you can't physically get to your office, then your business continues to run as normal.
Working from home on a bad snow day, is a great way of maintaining productivity when the weather turns bad and stops staff being able to get into the office.
Staff can boot up their devices at home – home PC, laptop, iPad etc, and access their files, emails and calendars in exactly the same was as they would in the office. And Microsoft Office 365 helps to make your tech even slicker. It brings you all the benefits of your usual Office software, together with data storage and internal intranet sites through OneDrive for Business and SharePoint Online, access anywhere emails and calendars through Exchange Online and intuitive communication capabilities through Lync Online. Lync takes your comms that step further with online meetings, live video conferencing and instant messaging helping teams to collaborate efficiently no matter where in the world they're based.
Which brings us nicely onto business comms. If staff are snowed in, cloud computing makes sure you're all in contact, working effectively, keeping the business running…but what happens to your phone lines? What happens to your customers ringing into the business while your staff are all at home? Well this is where VoIP can save the day.
VoIP stands for Voice Over Internet Protocol, and it's the technology of placing telephone calls over an internet line. And the key benefit in this type of scenario, is the flexibility. Mirroring the way that cloud works, when your telephone system uses broadband instead of traditional analogue lines, it will work from anywhere with an internet connection.
You use either an IP enabled telephone handset, or a headset combined with a piece of software known as a softphone installed onto your computer and that's it. Well, and the internet. So if you've had to stay at home, you just boot up your laptop, connect to the internet, plug in your headset or IP phone and you're away. All calls made to your regular business telephone number will arrive on your laptop, and you can transfer calls or call internally using your usual individual extension numbers.
Of course, there may be flaws to my plan. I'm assuming your staff all have the internet at home. And a company laptop or home computer. But let's face it, most of us do these days. If your teams can remain productive when they're unable to battle through the elements you will reap the benefits on your bottom line. It can also help keep morale high, letting your team stay in touch, keep on top of their workloads and even the peace of mind that they're not having to make dangerous journeys into the office when it's not necessary.
You can find loads of information about cloud computing services and VoIP solutions on our website here, and if you'd like a chat about how cloud could work for your business, pop in and see us – unless it's snowing. In which case, you might want to catch us on VoIP 01625 837800.
We've discovered that there may be an update to F-Secure that is causing machines to lose the TC/IP stack. To re-bind this to the machine you will need to get the user to run the following…
netsh int ip reset /c:resetlog.txt
At this point it will ask you to reboot. DO NOT REBOOT! Run the following, in this order…
int ip
Then reboot.
Much excitement at Axon Towers today, with the launch of Microsoft's HoloLens. What is it? It's the future, that's what. (Well, we're hoping so). A holographic headset, it creates hologram illusions in your field of vision, but unlike previous virtual reality devices, you can interact with objects. To give it its technical term – immersive augmented reality.
Sounds intriguing? It is.
It could transform the world as we know it. But will it? Will holographic virtual reality ever become our reality?
Take a quick look at this video and let us know what you think. Mindblowing stuff…
It has come to our attention that emails from the address firstname.lastname@example.com may present a security threat.
These emails purport to come from a company called FMG (http://www.fmg.co.uk/) but we have been in contact with this business and it has been confirmed that these are spam emails and nothing to do with FMG.
The email contains a link which will re-direct the user to various phishing websites. It also contains an attachment which SHOULD NOT be opened.
The attachment looks like this :-
The email is likely to take on a structure as per the below;
If you receive this email, delete it immediately and if you have any concerns then contact your IT support provider.
We're now at the end of our first full working week of the new year, so we thought now would be a good time to take a look backwards, and to delve in the archives.
We've pored over an entire years' worth of data and have identified our most popular blog articles from the last 12 months, which we've put together in this article for easy reference. You're welcome!
1. Unable to remove contacts from Lync Client (Office 365)
Are you having trouble removing contact or groups from your Lync contact list? Then this is the blog article for you – a full step by step guide to resolving the issue.
2. Input language won't change to English UK from English US in Windows 8.1
When we installed the Windows 8.1 update on a laptop we found that the machine automatically adopted the US English input language. Here's how to fix the issue.
3. Microsoft Office files slow to open from network share on SBS 2008 from Windows 7 Clients
We experienced the slow opening of Office 2007 files from network shares on SBS 2008 servers when accessed from Windows 7 clients. This article shows you how to resolve the issue.
4. Office 365 Subscription: How to reactivate office – Unlicensed Product
Need to reactivate an Office 365 subscription? Then try the following steps.
5. How to Stop the Local Downlevel Document from Appearing in the Print Queue
The solution is to disable Asynchronous RPC in the registry of the Windows Vista/7 client. This blog articles talks you through the process.
6. 'shared with me' not showing shared files in Microsoft OneDrive
If you find that 'shared with me' is not showing shared files in OneDrive, try the following fix to show files again.
7. Recovering a deleted mailbox in Microsoft Office 365
We had an issue where a mailbox had been deleted and the mail items hadn't been backed up. This article looks at how you can go about recovering a deleted mailbox in Office 365.
8. Installing Business Contact Manager (BCM) 2010 on Small Business Server (SBS) 2011
Business Contact Manager (BCM) 2010 can be installed locally on a PC or installed on a remote server where BCM database can be shared out between users of Business Contact Manager for Outlook 2010. Learn more here.
9. How to Enable Microsoft Threat Management Gateway (TMG 2010) to Accept Non-standard SSL Ports
As standard, Microsoft TMG (or ISA) will not allow access to sites that use non-standard SSL ports. Here are details on how to get around this issue.
10. Staged Exchange Migration to Office 365
Step by step instructions as well as useful links for configuring Outlook Anywhere and managing your migration to Office 365.
11. Cannot Access a CNAME network share from a Windows XP PC
We recently faced a problem whereby a customer's database server stopped working due to a hardware failure. The server was running on a physical box, This is the solution that we found.
When a user tries to connect to an FTP site from a PC where Internet Explorer is set to use a proxy server, they may receive an error message from the proxy server. Find out how to successfully connect via FTP in this article.
So there we have it, our 12 most popular blog posts from 2014 in order of popularity.
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Don't know mincing from chopping? Expand your humble culinary skills and turn into a cutting master, almost instantly, thanks to the illustration on this cutting board which explains it all. Topped with tempered glass, this board can handle a lot of abuse until you master your new skill.
Kitchen Stuff
Knife Skills Cutting Board
Kokeshi Bento Boxes
Take your lunch and keep it as appetizing as when you made it. The Kokeshi Bento Boxes feature three stackable compartments, with an airtight lid in the middle. It keeps your lunch neatly organized and separated so you don't end up eating mush. Apart from how useful they are, let's take a moment to recognize how adorable they look. That alone makes them worth having!
Uuni Stack
Uuni Stack makes dough proving organised and easy. The multi-use product is also great for cooking prep, chopping and stylish storage. Great dough is the bedrock of a great pizza and proving (or proofing, if you prefer) plays an important part in getting it right. We used to cover plates with cling film or find random containers to fill with dough balls but always found this to be… not such a great process. And so, Uuni Stack was born.
Street Map Pint Glasses
If you are already residing in New York, Boston or Pittsburgh or simply adore these cities, here's your chance to get them etched as the Street Map Pint Glasses. They are a 16 oz glass which looks extremely adorable because of the etching of the streets on the glass walls. Once filled with beer, the glasses looking nothing less than a beauty you'd surely want to capture from various angles behind your lens.
10 Cool Food Gadgets and Accessories For Your Next Holiday Party
Customizable Cookie Stamp:
This stamp comes with set of letters and a few symbols that you can use to stamp your own custom messages on your delicious cookies. Excellent for making cookies with holiday greetings on them!
Selby Beverage Dispenser:
The Selby beverage dispenser is made from glass, which makes it look beautiful on any table setting. The two compartment dispenser can hold more than 2 gallons, enough to quench everyone's thirst.
Ironwood Gourmet Acacia Wood Cocktail Plates:
Your guests will certainly appreciate these cocktail plates that hold appetizers and a glass of wine together with the use of one hand. Made of Acacia Wood, sold in a set of 4.
Corkcicle One Wine Chiller and Aerator:
The stainless steel Corkcicle features a special freezing gel that maintains chilled whites and cools down room temp reds. It also features a built-in aerator that enhances the aromatic profile of any wine. Simply chill the Corkcicle One in the freezer before use, when ready insert it into the bottle and pour right through it. A flip cap on the top will ensure that the bottle is sealed and the cool temp is always maintained.
Iced Fruit Infusion Pitcher:
Create and serve delicious fruit-infused drink with this pitcher. Cut your favorite fruit, insert it into the rod, add your drink of choice to the pitcher and top it of with the lid, which has a detachable frozen tube to keep the drink chilled. Result is a nicely chilled, infused drink without any pulp, seeds or diluted ice.
Picnic at Ascot Malvern Cheese Board Set:
Beautiful Bamboo wood cheese board with crackers rim and a hidden drawer that includes stainless steel cheese knives.
Cheesy Board by Mustard:
If you appreciate a bit of humor at the table, you'll love this tempered-glass Cheesy Board with the quote "To Brie or Not To Brie" on it.
Stem Metal & CitriTwist:
Allow your guests to add an extra kick of citrus to their food without the mess. This set includes a polished aluminum citrus spritzer and CitriTwist, a reamer that extracts every last drop of juice without making a mess.
Cake Slice Marker Set:
This marker set takes all the guess-work out of cutting equal pieces of cake or pies. The set includes 5, 6, 7, 9, and 11-piece makers that you simply place on top of your cake and it will mark the lines where you should cut for equal size of the exact number of pieces you want.
Marble Slab Ice Cream Mixing Set:
Serving Ice Cream for dessert? Might as well make it part of the evening's entertainment with this Marble Slab ice cream mixing set. It includes: a marble slab, which you need to freeze before use, 3 ceramic dishes for mix-ins, 2 stainless steel mixing spades and a bamboo base that holds all those components together.
11 Things You Need In Your Man Cave
Whether you already have a glorious man cave or still working on marking your territory, you know the cave can't just have anything in it. Things in your not so humble abode need to reflect your alpha maleness in every single respect; so here are our top picks for 11 things that you need in your guy grotto:
Star Wars™ X-Wing™ Knife Block:
If any set of knives deserves to be in your man-cave, this is certainly the pick of the bunch. This officially licensed Star Wars knife block takes the shape of an X-Wing fighter, giving your kitchen countertop a great sense of rebellion. The set includes 5 high quality stainless steel knives:
- Cook's knife: 8″ (200mm)
- Bread knife: 8″ (198mm)
- Carving Knife: 8″ (225mm)
- Utility knife: 4.75″ (122mm)
- Paring knife: 3.5″ (85mm)
Star Wars Lightsaber™ BBQ Tongs:
Now you've got your Star Wars X-Wing knives, you really shouldn't stop there. It'll be BBQ season before you know it and you simply cannot be seen prodding and flipping meat with any old pair of pincers. Enter the Star Wars Lightsaber Tongs, complete with authentic sound effects (because we know you're going to try to make the noise anyway).
Sugar Skull Spoon:
You already know too much sugar is bad for you, yet you can't resist the saccharin assassin. We appreciate we can't stop you, but this skull shaped sugar spoon is here to help. Thanks to its gothic design, no matter how much you scoop, it's never a proper spoonful, which reminds you in a way to take less. Plus, it simply looks awesome.
Caveman Mug:
You wake up hungover with a mouth like the bottom of a pterodactyl's nest. Stringing a coherent sentence together is out of the question (you're a Neanderthal remember) but you can just about manage enough of a grunt to communicate that you need coffee and you need it NOW! So it only makes sense that you have your morning cup of joe in a Caveman Mug – which also incidentally, is perfectly in-keeping with your choice of interior decoration.
Blade Runner Whiskey Glass:
Fans of the sci-fi Blade Runner should recognize this glass in a second. And if you're not quite sure… it's Deckard's favorite glass. This isn't a replica of it, it is actually handmade by the same designer who made the original glass. So when you sip your favorite drink out of it, you'll know what you have in hand is something special. It's a must-have for every sci-fi fan.
Beer Freeze Pint Glass:
Is there anything worse than warm beer? A lot of things probably, but what we're trying to say is, warm beer really sucks. But you don't have to put up with it anymore. Beer Freeze is a brilliant BPA-free plastic pint, with built-in cooling gel that chills any beverage instantly, and most importantly, it keeps it that way. Wrapped with a rubber grip so your hand doesn't freeze along with your drink.
Firefly Portable Laser Light:
The Firefly isn't just a portable light, it's a palm-sized portable light with laser beams! Creating an impressive party atmosphere is easy with the Firefly light; it uses low powered laser and glass optics to scatter laser light and illuminate the area without using much power (less than 1 watt!). It's also suitable for outdoor use, with an impressive ability to project light up to 100ft.
Hunting Trophy Door Light:
Hunter or not, you'll love having this Hunting Trophy Door Light in your Man Cave. Mount it on your wall and watch it automatically light up for 20 seconds as soon as you walk in; giving you enough time to reach the light switch or hang/grab your keys. Unlike real animal heads, this one is actually useful.
Glow-in-the-Dark Nuclear Soap:
Got a little bit of geek in you? Then this fresh Rainwater scented soap set is definitely a must-have. Although they look kind of dangerous to touch, these glow in the dark Nuclear soaps are perfectly safe and lot of fun.
Bruce Lee Playing Cards:
A deck of cards that provides a lot of entertainment and inspires you along the way. This Bruce Lee tribute is officially licensed by the Bruce Lee Enterprises, each card features a different philosophical quote from the legend's teachings. The Joker cards feature Bruce Lee in action, while the Ace cards have been left blank to symbolize a free mind
Subbuteo™ Bottle Opener:
Anyone who's enjoyed a game of Subbuteo, the iconic 80s tabletop game, will definitely want to have this bottle opener. It's more of a figurine, standing at 9cm high and made of solid die-cast metal. At the bottom of it is a handy cap remover, that opens your bottle with a quick flick of the wrist.
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