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Lancaster Airport, Inc.
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"I think we'll be able to sort it out, ... Don't forget, we have an opportunity to play on Monday Night football, and that's a great opportunity for us, as well as for the Saints. We'll put ourselves in the right frame of mind for Monday night."
Tom Coughlin
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Posts tagged blazej-krakowiak
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Apple to sell Leather Cases and Silicone Cases for iPhone 6 and iPhone 6 Plus
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bKey is an ultra-portable battery charger for iPhone that fits on your keychain
If you are anything like me, there are probably three things that you are guaranteed to leave the house with: your wallet, your keys and your smartphone. But when your iPhone dies while you are at school, work or elsewhere, without a charger to be found, it can be a frustrating situation. Fortunately, a new Kickstarter project for a product called the bKey aims to solve that dilemma.
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At the end of 2013, a keyboard case called the Typo was unveiled as the "perfect" accessory for your iPhone 5/5s. Immediately after the unveiling, Typo came under fire from its obvious design inspiration, BlackBerry, and so some changes needed to be made for the inexorable sequel. And here we are.
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iStick will let you transfer files between Mac and iOS devices, set to arrive as early as August
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Live Music by Hannah Zacharer
Thu, May 1, 2014
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Deep-set deep blue
sees the past-life detritus
of this wordyahtzee
kamakaze neo-artsy
taketwo tumbleweed.
Deep-set deep blue
sees he'll make good
for a brood of his blood,
upturning callous rocks
Breath will come easier,
death will seem further,
wan feet will root to earth;
the dearth of joie de vivre
put in
Deep-set deep blue
sees a man emancipated
from the slew of self.
Atelophobia n. (from the Greek: ατελής, atelès, "imperfect, incomplete" and φόβος, phóbos, "fear") is the fear of not being good enough, or imperfection.


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The effects of diazepam on human self-aggressive behavior
- Mitchell E. Berman,
- Gabriele D. Jones,
- Michael S. McCloskey
- … show all 3 hide
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Get AccessAbstract
Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not support a cause-and-effect relationship between benzodiazepine consumption and self-aggressive behavior.
To experimentally examine the effect of diazepam on human self-aggressive behavior under controlled laboratory conditions.
Forty-six healthy men and women were randomly assigned to receive placebo, or 5 mg or 10 mg diazepam in a double-blind, between-groups design. Participants were then provided the opportunity to self-administer electric shocks during a competitive reaction-time task (the self-aggression paradigm, SAP). Self-aggression was defined by the intensity of shock chosen.
Diazepam (10 mg) was associated with higher average shock self-administered than placebo. Subjects receiving 10 mg diazepam were also more likely to attempt to self-administer a shock that they were led to believe was "severe" and painful. Sedation effects were found, but diazepam consumption did not impair memory, attention, concentration, pain threshold, or reaction-time performance.
Clinically relevant diazepam doses may be associated with self-aggressive behaviors at levels that do not significantly impair basic cognitive processes or psychomotor performance.
- Alsén M, Ekedahl A, Löwenhielm P, Niméus A, Regnéll G, Träskman-Bendz L (1994) Medicine self-poisoning and the sources of the drugs in Lund, Sweden. Acta Psychiatr Scand 89:255–261
- American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington
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- Dietch JT, Jennings RK (1988) Aggressive dyscontrol in patients treated with benzodiazepines. J Clin Psychiatry 49:184–188
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- First MB, Gibbon M, Spitzer RL, Williams JBW (1998) Computer-assisted SCID—Clinician Version (CAS—CV) [Computer software]. Multi-Health Systems, North Towanda
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- Friedman H, Greenblatt DJ, Peters GR, Metzler CM, Charlton MD, Harmatz JS, Antal EJ, Sanborn EC, Francom SF (1992) Pharmacokinetics and pharmacodynamics of oral diazepam: effect of dose, plasma concentration, and time. Clin Pharmacol Ther 52:139–150
- Fuller GN, Rea AJ, Payne JF, Lant AF (1989) Parasuicide in central London 1984–1988. J R Soc Med 82:653–656
- Gantner AB, Taylor SP (1988) Human physical aggression as a function of diazepam. Pers Soc Psychol Bull 14:479–484
- Gardner DL, Cowdry RW (1985) Alprazolam-induced dyscontrol in borderline personality disorder. Am J Psychiatry 142:98–100
- Gardos G, DiMascio A, Salzman C, Shader RI (1968) Differential actions of chlordiazepoxide and oxazepam on hostility. Arch Gen Psychiatry 18:757–760
- Ghoneim MM, Mewaldt SP (1990) Benzodiazepines and human memory: a review. Anesthesiology 72:926–938
- Giancola PR (2000) Executive functioning: a conceptual framework for alcohol-related aggression. Exp Clin Psychopharmacol 8:576–597 CrossRef
- Gray JA (1988) Behavioural and neural-system analyses of the actions of anxiolytic drugs. Pharmacol Biochem Behav 29:767–769 CrossRef
- Hall RCW, Zisook S (1981) Paradoxical reactions to benzodiazepines. Br J Clin Pharmacol [Suppl 11]:45–49
- Hoddes E, Zarcone V, Smythe H, Phillips R, Dement WC (1973) Quantification of sleepiness: a new approach. Psychophysiology 10:431–436
- Krsiak M, Sulcova A (1990) Differential effects of six structurally related benzodiazepines on some ethological measures of timidity, aggression and locomotion in mice. Psychopharmacology 101:396–402
- Lester D (1995) Case consultation: diffusion of responsibility in the care of a difficult patient. Suicide Life Threat Behav 25:415–421
- Licata A, Taylor S, Berman M, Cranston J (1993) Effects of cocaine on human aggression. Pharmacol Biochem Behav 45:549–552 CrossRef
- McCloskey MS, Berman ME (2003) Alcohol intoxication and self-aggressive behavior. J Abnorm Psychol 112:306–311 CrossRef
- Neutel CI, Patten SB (1997) Risk of suicide attempts after benzodiazepine and/or antidepressant use. Ann Epidemiol 7:568–574 CrossRef
- Patton JH, Stanford MS, Barratt ES (1995) Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51:768–774
- Rappaport M, Braff DL (1985) Alprazolam and hostility. Am J Psychiatry 142:146
- Rosenkrans FM (1967) Choosing to suffer as a consequence of expecting to suffer: a replication. J Pers Soc Psychol 7:419–423
- Rothschild AJ, Shindul-Rothschild JA, Viguera A, Murray M, Brewster S (2000) Comparison of the frequency of behavioral disinhibition on alprazolam, clonazepam, or no benzodiazepine in hospitalized psychiatric patients. J Clin Psychopharmacol 20:7–11 CrossRef
- Spielberger CD, Gorsuch RL, Vagg PR, Jacobs GA (1983) State-trait anxiety inventory for adults. Consulting Psychologists, Palo Alto
- Steele CM, Josephs RA (1990) Alcohol myopia: its prized and dangerous effects. Am Psychol 45:921–933 CrossRef
- Taiminen TJ (1993) Effect of psychopharmacotherapy on suicide risk in psychiatric inpatients. Acta Psychiatr Scand 87:45–47
- Walster E, Aronson E, Brown Z (1966) Choosing to suffer as a consequence of expecting to suffer: an unexpected finding. J Exp Soc Psychol 2:400–406
- Weisman AM, Berman ME, Taylor SP (1998) Effects of chlorazepate, diazepam, and oxazepam on a laboratory measure of aggression in men. Int Clin Psychopharmacol 13:183–188
- Wilkinson C (1985) Effects of diazepam and trait anxiety on human physical aggression and emotional state. J Behav Med 8:101–104
- Title
- The effects of diazepam on human self-aggressive behavior
- Journal
Volume 178, Issue 1 , pp 100-106
- Cover Date
- 2005-02-01
- 10.1007/s00213-004-1966-8
- Print ISSN
- 0033-3158
- Online ISSN
- 1432-2072
- Publisher
- Springer-Verlag
- Additional Links
- Keywords
- Diazepam
- Self-aggressive behavior
- Laboratory measures
- Industry Sectors
- Authors
- Mitchell E. Berman (1)
- Gabriele D. Jones (1)
- Michael S. McCloskey (2)
- Author Affiliations
- 1. Department of Psychology, The University of Southern Mississippi, Hattiesburg, MS, 39406-5025, USA
- 2. The University of Chicago, Chicago, IL, USA


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KRISTEN DOUTE, Vanderpump Rules Aquarius Girl, Arsonist of Love!
What drives Kristen Doute, Vanderpump Rules, resident crazy pants and sexy Aquarius girl? Will she sign up for another season of the popular Bravo reality show? What does her Astrology birthday profile reveal?
Kristen Doute was born on February 19, 1983. Her Sun glimmers in the zodiac sign Aquarius, squared by Taurus Moon. She has a split personality, fueled by her obsession for Tom. Hell has no fury like a Kristen scorned. Lets face it, she's 'Cuckoo for Cocoa Puffs' and fans love it. Kristen knows how hot she is, who's most likely spent her life and relationships controlling men with her sexuality. She is pure ratings gold.
Her Venus and Mars conjunct in Pisces, make Kirsten Doute absolutely irresistible to the boys on Vanderpump Rules. She's manipulative, vulnerable, romantic and charismatic. No wonder, Jax, couldn't keep his slimy hands off of her and she drives poor Tom & James nuts.
According to Ask Men, the reason why guys are attracted to difficult women is because they express the anger they can't. What makes Kristen naughty catnip for the boys of Vanderpump Rules? She's an arsonist of love, who has the balls to say what they won't; and is an emotional terrorist who exposes their darkest secrets.
What does the astrological future hold for our Aquarius Princess? Personally, Astrochicks loves Kristen Doute; she's pure genius and our favorite reality show villain. Girl, don't ever change.
Astrochicks predicts she will appear on another season of Vanderpump Rules, but her relationship with boyfriend James is headed for troubled waters. (Sorry James – we still love you too.) Yes, jealousy will rear its ugly head and their rocky romance will play out, once again, across our television screens. The girl we love to hate will dial up the drama for another fun season of Vanderpump Rules. We can't wait!
MILEY CYRUS Dating Patrick Schwarzenegger, Heartbreak over Ex Boyfriend Liam!
Has Miley Cyrus a sexy Sagittarius girl finally moved on from ex boyfriend, Liam Hemsworth? Who is Miley dating now and what does she look for in a man? We took a peek at her Astrology chart and were surprised at what it revealed.
Miley Cyrus a former Disney star, celebrates her birthday on November 23, 1992. Her sun shines in Sagittarius, lit by Moon in Scorpio, with Venus in lusty Capricorn. She's a fun loving, free spirited chick, who can be moody and jealous, but desires security in a relationship. Translation, she's a wild stallion, who can be a handful and is attracted to men who can tame her.
In a recent Elle interview, Miley Cyrus revealed her previous struggle with depression and anxiety. Heartbroken over her intense break-up with Liam Hemsworth, she felt lost without him after ending their engagement in 2014.
What was the attraction between Miley and Liam? Her Venus in Capricorn conjuncts his Sun in Capricorn, made Liam her knight in shining armor. He grounded her and she felt safe with him.
Fortunately, Miley Cyrus has bounced back and is embracing her Sagittarius energy. Currently dating Patrick Schwarzenegger a Virgo, she would love his intelligence and good looks. His Moon in Libra compliments it, he definitely knows how to pour on the charm and makes her feel loved.
What does the future hold for Miley Cyrus and Patrick Schwarzenegger? No doubt, they make a passionate couple. She likes to speak her mind and he loves a little drama in his life, together they make wicked cocktail of love and sex. Our astrology prediction for Miley and Patrick is a serious relationship, without the wedding ring but taking their love for a test drive by living together. We predict a fun ride.
VALENTINES DAY, Fifty Shades Jamie Dornan Ruled by Love or Sex?
Fifty Shades of Grey the hottest ticket his Valentine's Day stars Jamie Dornan the panty dropper thespian will make fans swoon with his portrayal as Christian Grey. What does his Astrology profile reveal?
Ruled by Venus, Jamie Dornan celebrates his birthday on May 1, 1982. Born under the zodiac sign of Taurus, he's a true alpha male, who's a sexy combination of masculine charm and down to earth good looks.
When it comes to love, Taurus men are absolutely irresistible. He will sweep you off your feet, place you on a pedestal and worship the ground you walk on. Beware, Taurus men have exceptionally high standards when it comes to love, but once you capture his heart, he can be incredibly loyal.
What zodiac sign is Christian Grey? The Fifty Shades bad boy celebrates his birthday on June 18th. This makes him a Gemini who leans toward sexual experimentation and loves to get his freak on.
How do you seduce a Gemini man? With your MIND, BODY and SOUL! He's going to be excited not only by what you wear but what you say. He's definitely likes to talk dirty and enjoys acting out his sexual fantasies.
For Jamie Dornan his portrayal of Christian Grey is the right amount of naughty and nice. He shares a natural chemistry with co-star, Dakota Johnson a Libra. Both ruled by Venus they will bring a touch of romance to the Fifty Shades of Grey characters.
What does the future hold for Christian Grey and Jamie Dornan? Fifty Shades fans can expect the next two films to be more dark and twisted. We will get front row seats to the kinky mind of Christian Grey making fans wish they could spend one night in his playroom. Astrochicks predicts Fifty Shades of Grey movie to be a blockbuster hit and destined to be a cult classic.
DAKOTA JOHNSON, Fifty Shades of Grey, Sexy Libra Girl!
Dakota Johnson a sexy Libra girl is about to have her life turned upside down. This weekend, Fifty Shades of Grey will grace movie screens on Valentine's Day. Will she become a superstar in her portrayal as Anastasia Steele? What does her Astrology profile reveal?
Dakota Johnson celebrates her birthday on October 4, 1989. Born under the zodiac sign of Libra, she is the daughter of actors Don Johnson and Melanie Griffith. A third-generation Hollywood actress, Johnson attended Aspen Community School in Colorado.
A charming Libra girl, Dakota Johnson has Moon in mysterious Scorpio. She has intense emotional needs, the waters run deep for this actress and she's not afraid to channel her dark side. When you add the sultry water of Venus in Scorpio and Mars in Libra, she is one sexy sweetie pie, who likes to possess her man and can be quite the flirt.
When Dakota Johnson accepted the role in Fifty Shades of Grey, obsessive fans were not convinced that she could handle the role of Anastasia Steele. Since the sneak preview, Fifty Shades movie reviews have been mixed but Astrochicks believes fans will be pleasantly surprised. After all, she has Moon and Venus in Scorpio and definitely knows how to get her freak on behind closed doors.
What does the cosmic future hold for Dakota Johnson? Our Astrology prediction is our pretty little Libra girl can expect uber stardom, Fifty Shades of Grey will deliver the steamy sex scenes fans desire and will leave them panting for more.
SIA Swings from the Chandelier of Life, Sagittarius Astrology Profile!
Sia Australian's Empress of pop was born on December 18, 1975. A Sagittarius girl, the Singer/Songwriter has sold 25 million songs and penned musical hits for Flo Rida, Rihanna, David Guetta, Britney Spears, Celine Dion, Katy Perry, and for the new film Fifty Shades of Grey.
A fun and fearless Sagittarius songstress on stage, Sia has captivated the music world with her heart-rending lyrics and haunting songs like "Breathe Me" and "Chandelier". Off stage, Sia is incredibly private girl, who rarely gives interview. What mysteries does her Astrology chart reveal?
Her Moon and Mars in Gemini opposes her Sun in Sagittarius, crossed by Venus in Scorpio. Sia's Astrology chart reveals a charming and witty girl, who will hypnotize you with her sexual magnetism and surprise you with her brutal honesty.
Her Venus in Scorpio reveals a love life that may be laced with pain and sorrow. In a previous interview, Sia described her former boyfriend, Dan, as her "first true love". In 1997, the young couple had planned to travel the world together. Before taking off, Sia stopped off in Thailand while Dan continued to London. Sadly tragedy struck, Dan was killed in a traffic accident, only a week before Sia was due to arrive.
Today, Sia has transcended that tragic moment in life and recently married her Leo sweetheart, documentary filmmaker Erik Anders Lang, in August 2014.
Earlier this month, I had the opportunity to meet Sia and her husband at a Golden Globes event. I found her to be not only beautiful but also incredibly gracious. She had a very sweet spirit and was kind to everyone who spoke with her. Together, they made an adorable couple.
No doubt in 2015, our Sagittarius girl will continue to shake her moneymaker and will continue to climb the Billboard charts. Recently nominated for "International Female Solo Artist" at the Brit Awards, I predict our Sagittarius girl will continue to be a burning force in music for years to come.
BLAKE SHELTON and MIRANDA LAMBERT, Crazy in Love, Battle Divorce Rumors!
Blake Shelton and Miranda Lambert, country music's hottest couple rocked the Grammy's tonight. What's the driving force behind their love and what does their Astrology charts reveal?
Together Blake and Miranda make a fun and passionate couple. Miranda Lambert a Scorpio with her fiery temper, super sultry ways, keeps Blake Shelton a Gemini mentally and physically challenged. She keeps him grounded and loved up, he keeps her laughing and brings excitement to the relationship.
Astrologically speaking, for years Blake and Miranda have weathered the nastiest of breakup rumors. Shelton deals with gossip head on he regularly takes to Twitter to voice his opinion; "May be because the divorce rate is so high the tabloids have just decided to play the odds with me and Miranda. Morons!" At least he has a sense of humor.
What's the astrological glue that keeps Blake and Miranda together? Miranda Lambert's Moon in Capricorn keeps her emotionally grounded. Her Venus in Libra shows a girl who believes in love and her practical Mars in Virgo keeps her sane. Her husband Blake Shelton's Moon in Pisces makes him sweet and sensitive. The waters run deep for this country cutie, he's passionate a guy who's crazy in love. His Venus in Gemini shows a kinky side; no doubt, Blake and Miranda probably have lots of hot, dirty sex. Definitely, they are one sexy couple.
Saturn in Sagittarius will pose an emotional challenge for Blake Shelton in 2015. Perhaps he will be burnt out on work and miss not being by his lady love all the time. Miranda will ride the storm with her man; she's a tough cookie and will help him make the right choices. Forget about those divorce rumors, together, Blake and Miranda's love will continue to burn bright for years to come.


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"I wanted to get a gold charm that represented the dedication and love my son had for being a member of his college's marching band. This was for his 18th birthday. Since his college is a very well known school I thought it would be easy to find that charm. It wasn't I looked all over the internet and called my local jeweler. Couldn't find what I wanted anywhere. I luckily found your website. I called and spoke to Danny. This was to be a "custom" charm. We spoke and he gave me ideas that I never even thought of I was thrilled that finally I was able to get my son the charm I wanted too. I received the charm and it was beautiful, everything I expected and more. We gave my son the charm this weekend when we visited his school for Parent Weekend. He now owns something that no one else does and his fellow band mates/friends have given him numerous compliments. Thank you Danny and the others who helped make my idea a reality It was a pleasure and I would not hesitate to order from your company again."
-- Diane
"Love the lip prints and photo of my mother and daughter. This will mean the world to her as they were very close. Thanks so much for your time and understanding you gave me in this process. Your work is amazing. Telling all my friends about you"
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"The customer service from this company is exceptional. I ordered on a Thursday and had the product the next day. The product is beautiful!! I ordered this as a Christmas gift and couldn't be more pleased at the fast service and shipping. I will be ordering again from this company. Even my 11 year old son said, "Wow, grandma is going to LOVE this gift" Thank you!!"
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I just received the pocket watch I ordered for my husband for our first Christmas together. It looks amazing, you did such a lovely job! :)
Thanks so much..."
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"I am especially pleased with my "Picture on Gold." The artists filled in a part that had been cut off in the original picture... amazing. This is my fourth gift order, & I'll be back for more."
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"I come from australia and had had picture pendants done before but they did not last so I thought I would try Pictures on Gold. What a beautiful work of are I love it
Thank you Daniel for the wonderful workmanship"
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"I have never written a testimonial before, but I was so impressed with the quality of workmanship and speed of service from PicturesOnGold.com that I felt compelled to write. Last year I had been looking for a very special Christmas gift for my sister-in-law in memory of her son who passed away just four months earlier. I saw your website for photo pendants advertising "Guaranteed for Christmas", but to be honest was skeptical ordering it so late. I placed my order online Tuesday 12/7 and was amazed to receive my delivery by Thursday – just two days later. The pendant really is exquisite; it captured the photo of my nephew beautifully and the special message was engraved on the back. My sister-in-law has never taken it off and said she is going to cherish it forever. I have shared your website with many friends and family.
Wishing you All a Joyous Christmas,
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"I have never been so happy with a purchase. From beging to end. It was so easy to order, it arrived so quickly. And most of all, it is absolutly beautiful. I got this for a gift, but now I am going to buy myself one. I am telling everyone I know about picturesongold.com. I will be back again and again. I'm already thinking about christmas gifts."
-- Donna A.
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Toronto Police are trying to track down a boy missing from the Junction.15-year-old Shawn Walters was last seen in the west-end neighbourhood Wednesday afternoon, near Evelyn Ave and Evelyn Cr.He's described as black with a light complexion, 5'7 with a thin build and short, curly black hair. He was last seen wearing a grey T-shirt, black pants and black running shoes.Anyone with information on Shawn Walters' whereabouts is asked to call police at 416-808-1100 or to contact Crime Stoppers.
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Eintracht Frankfurt have confirmed that they have pulled away from a deal for Nicklas Bendtner.
The Bundesiga outfit have been interested in Bendtner since last season, and they have been in talks with him since he left Arsenal at the end of the 2013/14 campaign.
But Frankfurt have now admitted defeat in their bid to lure the 26-year-old Denmark international striker to the Commerzbank-Arena.
Frankfurt manager Thomas Schaaf told kicker-Sportmagazin: "It's true, we have made no progress (in those talks with Nicklas Bendtner), that's why we need to focus on different agendas."
Bendtner is believed to be hoping to stay in the Premier League and has been linked with Aston Villa in recent weeks.


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Feeding The Homeless In Fredericksburg
Similar Photos: government other | non profit non event | non profit | feeding the homeless | fredericksburg | va | feedfred | breakfast
Design Your OwnOur t-shirt experts are ready to help until midnight, Monday - Friday.
Mon.-Fri. 8am-12am | Sat. 10am-6pm | Sun. 10am-9pm


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Just Extend
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Youth Calender of Events
Senior High Mission Trip 2010
Our Youth Ministry encourages Middle School Students (Grades 6-8) and High School Students (Grades 9-12) in our church and community to develop a personal relationship with Jesus Christ. We study God's word, worship together, fellowship with one another, and serve in Spartanburg and around the world. These experiences equip us to glorify God wherever we are! Join us and bring a friend!
Navigating the Choppy Waters of Church Controversy It's no secret that our church (and denomination) are going through rough waters. ... more
Soup or Salad Imagine your favorite summer salad. You can include anything you like, with one exception—no dressing. ... more
Sleeping In And if you're anything like my parents, you don't wake up on Monday morning and ask them if they want to go to school today. You simply expect that they will go. ... more
About Plain Talk... One of the great things about my work here in the church is that it allows me the opportunity to meet with students and parents in all kinds of settings. Whether it is working out together in our Family Life Center or grabbing a biscuit at Bojangles, I'm constantly amazed by what I learn (and what you share) in these very ordinary places. In a way, it's like sitting halfway up the stands on the fifty-yard line: I'm close enough to hear the struggle, but far enough removed to notice the formations and watch the plays develop. In short, I have a perspective that those in the trenches do not. This perspective allows me to discern patterns and trends that are not always immediately apparent. Yet the purpose of this blog is more than "trend analysis." First of all, I'm not a disinterested observer. I'm fully invested. I want what's best for you and your families, and I will be completely candid in my assessments. More importantly, however, I want to exhort and encourage you. Often we are afraid to acknowledge our struggles out of fear, guilt, and shame, and as a result, we end up feeling isolated. Let me assure you, however, you are not alone! As I survey the field, I see variations of the same themes over and over. I can almost guarantee you that whatever you're going through, another family right down the street is experiencing as well. My hope is that these weekly blogs will strengthen and encourage you for the challenges you face, and help you live out God's calling in your lives. I want to come along beside you by offering food for thought, resources I've discovered, reflections on what we're teaching your students, and a few practical suggestions. Finally, please know that I treasure the trust you've demonstrated by sharing your stories with me. While the content of this blog may hit close to home, it will in no way compromise anything you've told me in confidence.
I hope you find this helpful, and as always, please let me know how I can best minister to you and your family.
In Christ, Jason
Real Life - Select Sundays in Family Life Center (5-7:00pm) Middle School and High School Sunday School (9:45-10:45am) WAF Bible Study - Wednesdays in High School Classroom (6:30pm-7:15pm)
2015 CALENDAR January 25 - Real Life February 1 - Super Bowl Sunday (Flag football and cookout at Spartan High from 12:30-3:30pm) February 6-8 - Confirmation Retreat at Bonclarken February 8 - Real Life February 22 - Real Life March 1 - Real Life March 7 - Confirmation Retreat at FPC March 8 - Youth Sunday March 15 - Real Life March 20-21 - Palmetto Relay March 22 - Fun Activity: Bowling March 29 - Real Life April 12 - Real Life April 17-19 - Confirmation Retreat at Montreat April 26 - Confirmation Sunday, Fun Activity: Gravitopia May 3 - Real Life (Service Project) May 17 - Baccalaureate Sunday, Real Life May 31 - End of School cookout June 20-27 - Salkehatchie Summer Service July 6-9 - Shine-on Spartanburg Mission Crawl July 18-25 - Montreat Sr. High Youth Conference
For more information on our youth programs contact
Jason Moore, Director of Youth Ministry Email:email@example.com Shannon Stewart, Administrative Assistant Email: firstname.lastname@example.com Phone: 208-2133
Jason Moore, Director of Youth Ministry Email:firstname.lastname@example.com
Shannon Stewart, Administrative Assistant Email: email@example.com Phone: 208-2133


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Weekend Box Office: 'Focus' Opened Worse Than 'After Earth,' WB Blames The Weather
'Focus' is on track to be Will Smith's lowest-grossing film since 'Bagger Vance.'
'Focus' is on track to be Will Smith's lowest-grossing film since 'Bagger Vance.'
It's a teddy bear with a blindfold and handcuffs.
Eddie Redmayne is the immortal space-king of Oscar bait.
If you see one movie this winter don't see 'Focus'!
These young ladies get their first taste of Channing Tatum in 'Magic Mike' and they will never be the same.
Aaron Seltzer and Jason Friedberg are back with 'Superfast!,' another collection of recycled jokes mocking the 'Fast and Furious' films.
A majority of Oscar watchers polled want Neil Patrick Harris to return as host.
Neil Blomkamp says 'the story wasn't fully there' in Elysium.
'Fifty Shades of Grey' is so sexy, some people just lose all control.
The Oscars, 'Fifty Shades of Grey,' and it's time to think... piece, with Bret.
"So, it's Alien, Aliens, this movie," he said, referring to his ideal canonic timeline.
Wouldn't it be nice to watch this trailer, in the kind of world where it belongs.
Katness Bellaswan got a haircut in the new trailer for Tween Dystopia XJ-1000.
"The United States Air Force established Lookout Mountain in 1947 in order to produce movies and photographs of nuclear tests."
The brand new poster for Marvel's 'Avengers: Age of Ultron' is jam-packed with characters and a few extra names to confirm some rumors.
101 gay couples bought their lifetime ticket to Flavortown this weekend.
Kat Dennings and Chad Michael Murray made a chad michael movie about how hard high school is.
"I believe you are confused, sir, I am a priest."


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March 21, 2008
A Skeptic Near Pinewoods CemeteryRate this encounter: Kyle S., Troy, New York, March 13, 2008I will be the first to declare myself a skeptic, as a matter of fact, I am a professional magician, specifically mentalism. I am not swayed by what I see, in fact, I make money off of fooling people. I am not a scam artist in any way, and I do not (outside of the stage) claim any paranormal abilities. That said, I do live within five miles of Pinewoods, or Forest Park Cemetery. I have lived in this house close to fourteen years, and I have never seen a thing, felt a thing, or have had any unnatural goings on happen in the time I have lived here. This is a new house (recently built), and we are the first occupants. Me and my friend were at my house studying in the basement. It was about ten at night or so, give or take, and he says, "Dude, there is a black orb floating down the stairs." I look up from my laptop and say, "Stop pounding monsters, man." About three or four minutes later, I stretch out my muscles, and I see something moving in the shadows in my Dad's woodshop. There are two ways in there, and one is blocked off by a stack of wood for the woodstove, which we use to heat our house. The other I was looking through, there are no windows in that room nor access that I could not see. At that instant me and my friend both feel chills, the temperature dropped 10 degrees, give or take, but the woodstove was still going strong. But it gets better... at the very instant the temperature drops, we feel pain, in the exact same place -- right at the kidneys. And our eyes started watering inexplicably. It was like a switch -- it would start and stop. So we were a little freaked out, but I being the braver (and arguably dumber of the two of us) decided to talk to it. I asked a series of questions, like, Who are you? Why are you here? But I asked where is your body, and pointed, and I made a 360-degree turn and stopped when we started feeling pain again. I pointed in the direction Pinewoods is from my house. I have no reason to lie. That is what happened, and I would welcome anything anyone has to say.
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Our latest posts 'Ghost Hunters' Star Launches Ghostly Workshop SeriesNEW BEDFORD, MA – Strange Escapes, a boutique paranormal event company founded by Amy Bruni of the SyFy network show, Ghost Hunters, has announced a...The Demon in My HouseWitness: Wendi Brown Location: Portland, Oregon Date of Encounter: January 1, 1983 My ex, my two-year-old son, and myself moved into a house in southeast...The Demonic AttachmentWitness: Location: Elkville, Illinois Date of Encounter: January 17, 2015 I've had many paranormal encounters throughout my life but recently it's taken...Ouija® to Celebrate its 125th Anniversary at OUIJACON in Baltimore April 23-25Talking board collectors, historians, paranormal experts, and fans to gather to discuss the world's most enigmatic "game" in the city where it...Making Contact in Stirling CemeteryWitness: Location: Aldgate, South Australia, Australia Date of Encounter: December 4, 2014 Wow, this happened to me just last night. I had been...A Visit from BillWitness: Laurie Maley Location: Yardley, Pennsylvania Date of Encounter: December 7, 2014 This just happened during the night. My daughter Courtney was... |


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find part for chandelier
I have my grandmother's chandelier, probably made in the 1960s.
It has 3 lights. One of the light conduits burned to a crisp. Any ideas about where I can find parts to replace this? (circular, cardboard type material to seperate the positive from the negative). BTW: I am a New Yorker, don't have any DYI skills, but a friend of a friend asked an electrician who told me the above. Hope it makes sense! |
might check Home Depot over on 23rd and 5th or up on Lexington at E60th they have a big lighting and chandelier sections with ons of lighting parts...is it just the socket that cooked where the bulb screws into like these.... http://www.grandbrass.com/sockets.cfm
You migth want to google Angelo lighting to see if they have the part.
All times are GMT -5. The time now is 07:05 AM. |


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Desert Essence Jojoba Oil - 100% pure
1259 reviews
85% would repurchase
Package Quality: 2.9
Price: $$
Package Quality: 2.9
Price: $$
Not tested on animals
Organic Simmondsia Chinensis (Jojoba) Seed Oil.Age: 30-35
Skin: Dry, Medium Brown, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
I saw many good reviews about this and decided to give it a try but Im not sure if this product actually works.
Im using it as a moisturizer for face and for my back and i have to say it is OILY. As it is so oily, i do not know whether it has good absorbance or not. I see many reviews here it is not oily and absorb fasts but it is really oily to me!
Age: 18 & Under
Skin: Acne-prone, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
Jojoba oil is the only product I use to keep my skin clear and it works very well. I will occasionally get a few pimples if my skin is irritated, but since I started using the oil about a year ago, my skin is drastically better. I put it on every night and it leaves my skin moisturized, although pretty greasy during the night but I've learned to live with it. It leaves my skin glowing with smaller pores and an even complexion, and most importantly almost no acne.
Age: 19-24
Skin: Sensitive, Tan, Cool
Hair: Black, Wavy, Medium
Eyes: Brown
bought it based on the awesome reviews but definitely didn't work for my sensitive skin. Worked well at first but overtime it made me break out in cystic acne and made my skin become more sensitive.
Age: 30-35
Skin: Combination, Fair-Medium, Warm
Hair: Black, Straight, Medium
Eyes: Brown
I really had high hopes for jojoba oil but YMMV with any carrier oil... I used it for a week and by the end of the week my pores were clogged (even pores near my eyes where the skin should be pore-less!) Now I'm very wary of jojoba oil listed in the ingredients of any product. It can also be listed as Simmondsia chinensis. Buyer beware...
Age: 19-24
Skin: Combination, Medium Brown, Warm
Hair: Brunette, Curly, Coarse
Eyes: Brown
I really wanted this to work for me because it works really great in my hair. However, to much of my dismay, it worsened my skin. I used this for about three weeks and I found that it make my face breakout into small bumps all over my face. Initially, I thought this was the "purging period". Alas, it was not. I guess I'll just stick to it for my hair.
Age: 44-55
Skin: Very Dry, Fair-Medium, Not Sure
Hair: Blond, Other, Other
Eyes: Blue
I will always have some of this on hand to remove eye makeup because every other makeup remover I have ever tried either doesn't get it all off, strips my skin dry, or is irritating and burns. I also use it on my face as an extra moisture boost, a few drops in my hair when it is feeling dry, and I also mix it with other oils (almond, apricot, coconut) for the body. my only complaint is the packaging, as it sometimes leaks or dribbles out more than I need (I find it hard to get just a few drops out). Otherwise it is a great lightweight oil that is great for a bunch of different uses.
Age: 30-35
Skin: Sensitive, Tan, Not Sure
Hair: Red, Other, Other
Eyes: Grey
One of the questions was: "If you ran out or lost this product would you buy it again?"
I think I'll NEVER run out, I just use 2 drups a day and its GREAT value for money!
Love this. Very soothing to my confused skin, plus it helped clear up zits, my oily t-zone and my dry spots on my cheeks. Doesn't smell pretty, but doesn't smell bad either. Just kind of faintly herbal rooty.
Age: 25-29
Skin: Combination, Medium, Warm
Hair: Brunette, Wavy, Fine
Eyes: Brown
I am new to the oil for beauty world and I must see I am noting it. My main uses for the jojoba oil is to remove the remainder of my eye makeup after I have used some of my makeup remover. The jojoba oil gently removes the stubborn mascara, strengthens and conditions my lashes and moisturizes my undereye area. All perks!! Oh and I use two drops on my dry hair when it looks a bit frizzy only at the ends. Love this product.
Age: 25-29
Skin: Normal, Fair-Medium, Cool
Hair: Other, Other, Other
Eyes: Green
Use a drop or two to revive any Mac paint pots that are going dry. Overnight, it sinks in and the Paint pot is as good as new.
Age: 36-43
Skin: Sensitive, Medium, Warm
Hair: Black, Wavy, Medium
Eyes: Brown
I was disappointed with the DE Jojoba oil. Either the oil is of the refined type or has some additives or jojoba oil in general is probably not suitable for my skin :( It caused the 3 Bs - breakouts, blackheads and also some small boils on the face! Aura Cacia Jojoba oil also caused same skin problems for me.
I googled and found this link. Apparently all jojoba oils are not equal calibre and it makes sense to test which oil works best depending on your skin type (oily, sensitive, etc). Jojoba oil also has a loooong shelf life. That should be the clue...
For my skin type (sensitive), I swear by sesame and almond oils. They are sooo nourishing and moisturizing! Ghee and coconut also work well.
Refer to Pratima Raichur's book. It has great information on skincare and using natural oils to moisturize, nourish and cleanse. Jojoba oil is not even listed there...probably Jojoba is a relatively new oil at least for use in skincare.
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Jesper Office Professional 100 Series Managers Desk Shell
Versatile pieces are the building blocks of the favorite Jesper Office 2000 Office, Entertainment and Library Collection. Cleverly designed to help you customize or integrate rooms in your home or office, this remarkably flexible system includes both pre-configured and modular pieces to make customizing a spacious, organized workspace easy.
Jesper Office Professional 100 Series Managers Desk Shell
Weights & Dimensions
Desk Type: Desk shell | Top Finish: 1: Brown |
Top Finish: 2: Espresso | Top Material: Manufactured Wood |
Base Material: Manufactured Wood | Non-Toxic: Yes |
Style: Industrial | Design: Standard desk |
Cable Management: Yes | Keyboard Tray: No |
Drawers Included: No | Drawer Pedestal Included: No |
Exterior Shelving: No | Cabinets Included: No |
Handedness: Both left and right | Scratch Resistant: Yes |
Legs Included: No | Casters Included: No |
Hutch Included: No | Treadmill Included: No |
Cork Back Panel: No | Modesty Panel: Yes
CPU Storage: No | Built In Outlet: No |
Built In Surge Protector: No | Light Included: No |
Finished Back: Yes | Modular: No |
Lifestage: Teen; Adult | Application: Professional office |
Commercial Use: Yes | Country of Manufacture: China |
Solid Wood Construction: No |
Assembly Required: Yes | Additional Parts Required: No |
Product Warranty: 5 Year Warranty |
About the Manufacturer
Jesper Office specializes in making modular office furniture for the home and small business, along with a complementary line of modular library and home entertainment furniture. The company, originally based in Denmark, has been designing and manufacturing high quality furniture since 1935. Today, Jesper Office is based in Bridgewater, New Jersey where it maintains a U.S warehouse and sales office along with several manufacturing facilities overseas.STYLE
Jesper Office Professional 100 Series Managers Desk Shell
Still have questions about this product? We're here to help
Customer Reviews
5 star | 6 | |
4 star | 1 | |
3 star | 0 | |
2 star | 0 | |
1 star | 1 |
grest versatile desk Karen from Denver, CO– Verified Buyer It is nice to have a desk with long modesty panel. This has a really clean design. The grommet is a bonus. |
NO QUALITY CONTROL Ernest from Carmel, CA– Verified Buyer this arrived with the desktop piece cracked on one side, as if they supported it by its ends on sawhorses and then some huge fat guy (or girl) weighing at least 1,000 pounds plopped down on it. It didn't break entirely in half, so it passed quality inspection and they shipped it (carefully protecting the broken part with 2 sheets of 1/8 inch thick styrofoam, both of which arrived undamaged indicating that the part was not damaged during shipping. The crack was on the bottom side, so the desk still functioned. Two other items I ordered came incorrectly assembled. My impression of this company is they ship everything with no inspection at all, and you wait a long time to get it. |
Managers desk Catherine from Massapequa, NY– Verified Buyer– Top 500 Reviewer This desk was a great but for the price. Needs two people to put together but worth the extra time spent. |
Solid Desk TATEone from North Carolina I bought this desk because I had just moved into my first house and it was time to have something that wasn't from my college days. I wanted something nice and simple but also solid and modern looking. This desk is both of those things. I managed to put it together myself and move it into place, and I can attest that this thing is well made. Being 63" this desk gives plenty of room for a wide screen monitor, cable modem, eternal hard drive, etc. without looking at all cluttered. I don't know what else I can say except that this desk was exactly what I was looking for. |
Good Product Robert from Novelty, OH– Verified Buyer Pros: Sturdy and well priced. Easy to assemble. |
Valued Customer from Texas– Verified Buyer |
Valued Customer from Michigan |
Valued Customer from Alabama– Verified Buyer |
Professional 100 Series Managers Desk Shell is also sometimes listed under the following manufacturer numbers: 16332-CH, 16332-ESP, 16332-WAL


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March 11, 2014
Infinity Show Band members Dawn Michelle, left, and Natalie Rojas perform at Arts Clayton's annual Arte Gras fundraiser Saturday. (Staff Photo: Curt Yeomans)
Stories this photo appears in:
For the kids
Arts Clayton's Arte Gras raises money for children's education programs
Hundreds of big "kids" partied together Saturday to raise money for little children.
Use the comment form below to begin a discussion about this content.


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From Wikipedia, the free encyclopedia - View original article
Tumor necrosis factor | |||||||||||||
PDB rendering based on 1TNF. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | TNF ; DIF; TNF-alpha; TNFA; TNFSF2 | ||||||||||||
External IDs | OMIM: 191160 MGI: 104798 HomoloGene: 496 ChEMBL: 1825 GeneCards: TNF Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 7124 | 21926 | |||||||||||
Ensembl | ENSG00000204490 | ENSMUSG00000024401 | |||||||||||
UniProt | P01375 | P06804 | |||||||||||
RefSeq (mRNA) | NM_000594 | NM_001278601 | |||||||||||
RefSeq (protein) | NP_000585 | NP_001265530 | |||||||||||
Location (UCSC) | Chr 6: 31.54 – 31.55 Mb | Chr 17: 35.2 – 35.2 Mb | |||||||||||
PubMed search | [1] | [2] | |||||||||||
Tumor necrosis factor (TNF, cachexin, or cachectin, and formerly known as tumor necrosis factor alpha or TNFα) is an adipokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons.[1]
The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease,[2] cancer,[3] major depression[4] and inflammatory bowel disease (IBD).[5] While still controversial, studies of depression and IBD are currently being linked to TNF levels.[6] Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
The theory of an anti-tumoral response of the immune system in vivo was recognized by the physician William B. Coley. In 1968, Dr. Gale A Granger from the University of California, Irvine, reported a cytotoxic factor produced by lymphocytes and named it lymphotoxin (LT).[7] Credit for this discovery is shared by Dr. Nancy H. Ruddle from Yale University, who reported the same activity in a series of back-to-back articles published in the same month.[8] Subsequently in 1975 Dr. Lloyd J. Old from Memorial Sloan-Kettering Cancer Center, New York, reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF).[9] Both factors were described based on their ability to kill mouse fibrosarcoma L-929 cells. These concepts were extended to systemic disease in 1981, when Ian A. Clark, from the Australian National University, in collaboration with Elizabeth Carswell in Dr Old's group, working with pre-sequencing era data, reasoned that excessive production of TNF causes malaria disease and endotoxin poisoning.[10][11]
The cDNAs encoding LT and TNF were cloned in 1984[12] and were revealed to be similar. The binding of TNF to its receptor and its displacement by LT confirmed the functional homology between the two factors. The sequential and functional homology of TNF and LT led to the renaming of TNF as TNFα (this article) and LT as TNFβ. In 1985, Bruce A. Beutler and Anthony Cerami discovered that cachectin (a hormone which induces cachexia) was actually TNF.[13] They then identified TNF as a mediator of lethal endotoxin poisoning.[14] Kevin J. Tracey and Cerami discovered the key mediator role of TNF in lethal septic shock, and identified the therapeutic effects of monoclonal anti-TNF antibodies.[15][16] More recently, research in the Laboratory of Mark Mattson has shown that TNF can prevent the death/apoptosis of neurons by a mechanism involving activation of the transcription factor NF-kappaB which induces the expression of Mn-SOD and Bcl-2.
The human TNF gene (TNFA) was cloned in 1985.[17] It maps to chromosome 6p21.3, spans about 3 kilobases and contains 4 exons. The last exon codes for more than 80% of the secreted protein.[18] The 3' UTR of TNFα contains an AU-rich element (ARE).
TNF is primarily produced as a 212-amino acid-long type II transmembrane protein arranged in stable homotrimers.[19][20] From this membrane-integrated form the soluble homotrimeric cytokine (sTNF) is released via proteolytic cleavage by the metalloprotease TNF alpha converting enzyme (TACE, also called ADAM17).[21] The soluble 51 kDa trimeric sTNF tends to dissociate at concentrations below the nanomolar range, thereby losing its bioactivity. The secreted form of human TNFα takes on a triangular pyramid shape, and weighs around 17-kD. Both the secreted and the membrane bound forms are biologically active, although the specific functions of each is controversial. But, both forms do have overlapping and distinct biology activities.[22]
The common house mouse TNFα and human TNF are structurally different.[23] The 17-kilodalton (kDa) TNF protomers (185-amino acid-long) are composed of two antiparallel β-pleated sheets with antiparallel β-strands, forming a 'jelly roll' β-structure, typical for the TNF family, but also found in viral capsid proteins.
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 is 55-kDa and TNFR2 is 75-kDa.[24] TNFR1 is expressed in most tissues, and can be fully activated by both the membrane-bound and soluble trimeric forms of TNF, whereas TNFR2 is found only in cells of the immune system, and respond to the membrane-bound form of the TNF homotrimer. As most information regarding TNF signaling is derived from TNFR1, the role of TNFR2 is likely underestimated.
Upon contact with their ligand, TNF receptors also form trimers, their tips fitting into the grooves formed between TNF monomers. This binding causes a conformational change to occur in the receptor, leading to the dissociation of the inhibitory protein SODD from the intracellular death domain. This dissociation enables the adaptor protein TRADD to bind to the death domain, serving as a platform for subsequent protein binding. Following TRADD binding, three pathways can be initiated.[25][26]
The myriad and often-conflicting effects mediated by the above pathways indicate the existence of extensive cross-talk. For instance, NF-κB enhances the transcription of C-FLIP, Bcl-2, and cIAP1 / cIAP2, inhibitory proteins that interfere with death signaling. On the other hand, activated caspases cleave several components of the NF-κB pathway, including RIP, IKK, and the subunits of NF-κB itself. Other factors, such as cell type, concurrent stimulation of other cytokines, or the amount of reactive oxygen species (ROS) can shift the balance in favor of one pathway or another. Such complicated signaling ensures that, whenever TNF is released, various cells with vastly diverse functions and conditions can all respond appropriately to inflammation.
This protein may use the morpheein model of allosteric regulation.[29]
TNF was thought to be produced primarily by macrophages,[30] but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[1] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). In the skin, mast cells appear to be the predominant source of pre-formed TNF, which can be released upon inflammatory stimulus (e.g., LPS).[31]
It has a number of actions on various organ systems, generally together with IL-1 and Interleukin-6 (IL-6):
A local increase in concentration of TNF will cause the cardinal signs of Inflammation to occur: heat, swelling, redness, pain and loss of function.
Whereas high concentrations of TNF induce shock-like symptoms, the prolonged exposure to low concentrations of TNF can result in cachexia, a wasting syndrome. This can be found, for example, in cancer patients.
Said et al. showed that TNFα causes an IL-10-dependent inhibition of CD4 T-cell expansion and function by up-regulating PD-1 levels on monocytes which leads to IL-10 production by monocytes after binding of PD-1 by PD-L.[32]
Recent research by Pedersen et al. indicates that TNFα increase in response to sepsis is inhibited by the exercise-induced production of myokines. To study whether acute exercise induces a true anti-inflammatory response, a model of 'low grade inflammation' was established in which a low dose of E. coli endotoxin was administered to healthy volunteers, who had been randomised to either rest or exercise prior to endotoxin administration. In resting subjects, endotoxin induced a 2- to 3-fold increase in circulating levels of TNFα. In contrast, when the subjects performed 3 hours of ergometer cycling and received the endotoxin bolus at 2.5 h, the TNFα response was totally blunted.[33] This study provides some evidence that acute exercise may inhibit TNF production.[34]
TNF promotes the inflammatory response, which, in turn, causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma. These disorders are sometimes treated by using a TNF inhibitor. This inhibition can be achieved with a monoclonal antibody such as infliximab (Remicade), adalimumab (Humira) or certolizumab pegol (Cimzia), or with a circulating receptor fusion protein such as etanercept (Enbrel).
TNFα has been shown to interact with TNFRSF1A.[35][36]
Some recent papers have argued that TNFα should simply be called TNF, as LTα is no longer referred to as TNFβ.[37]
In human cells, contrary to results previously obtained in a rodent model, TNF seems not to be glycosylated and, thus, trafficking is carbohydrate independent. In an effort to localize the amino acid motif responsible for granule targeting, we constructed additional fusion proteins and analyzed their trafficking, concluding that granule-targeting sequences are localized in the mature chain of TNF and that the cytoplasmic tail is expendable for endocytotic sorting of this cytokine, thus excluding direct interactions with intracellular adaptor proteins


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FIG. 1 is a front, top and left side perspective view of a control panel for endoscope showing our new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a top plan view thereof;
FIG. 5 is a bottom plan view thereof;
FIG. 6 is a right side elevational view thereof; and,
FIG. 7 is a left side elevational view thereof.
The elements within the broken line rectangles in FIG. 5 form no part of the claimed design.


text:
Reviewed By BOB B (STERLING, IL) Reviewed for a 2014 Dodge Ram —3/3/2015 1:07 PM
Covers for Ram 4500. Fit real nice. Look OEM. Not like some of the fit all type. Made just for this application. Would recommend.
Reviewed By Jim L (ROCKY MOUNT, NC) Reviewed for a 2014 Ford F-150 —3/3/2015 7:58 AM
Fit my 2014 F-150 seats like a glove and look great also. The color (gray & black) almost match my interior perfectly. Could not be more satisfied with my purchase. Will definitely recommend this product.
Lincoln Aviator Luxury Neoprene Seat Covers Lincoln Aviator Premium Neoprene Seat Covers Lincoln Aviator Ultimate Neoprene Seat Covers |


text:
Share your reviews,
photos and videos here!
Involvement:General (knows how to use it) - Ownership:1 week to 1 month
Pros:It is a good device, but I needed a device to share the same source of video in two Televisions, this device do the opposite receives two devices to connect in one tv. Its is good to TV that gets only one HDMI input.
Cons:NIHIL. I can't see nothing cons on this device.
OtherThoughts:Good materials used to assembly the gadget, but I needed other equipment to split the hdmi signal of the blue-ray equipment, to do this I will need an other type of equipment.
Bottomline:Good device with a nice materials. The price is very good in special when you search in the Brazilian market this kind of equipment is 4 times more.
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text:
In response to zbellino's comment:
7 out of 9 is amazing. There are probably only a small handful of performances by ANY offense this season that are in that league.
The offense was flawless today.
The offense as good as it was today could have done even better. The Ridley false start, a couple of key drops, no Hernandez.. They can play even better and IMO will . They may have a game where they score touchdowns on every single drive.


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From marketing and manufacturing to banking and nonprofits, UC Davis Graduate School of Management alumni pursue careers in a variety of industries.
My career path to date is…winding.
After earning my UC Davis MBA, I went to work in finance at Hewlett-Packard. I gained so much valuable experience working for a large company, but I realized after having my first child that I wanted more flexibility in my work schedule.
My career path has been a climb across a jungle gym rather than a tangent up a corporate ladder. As a child, I used to thumb through the three-inch JCPenney catalogue, picking out the professional women who I would grow to be. I wanted to rule the world from a corner office in a suit and heels. I wanted to shed my humble origins and become Corporate Barbie.
Sonny Aulakh MBA 08 grew up in Italy, married his college sweetheart more than 20 years ago, and has two daughters he would do anything for. His first job was as a gas station attendant, but his career began as a sales engineer in Silicon Valley after graduating from Cal State Sacramento. After working in Silicon Valley for eight years, he moved into management—and decided to earn an MBA.
Morgan Lee MBA 99 has worked for some of the best-known and respected brands in the global marketplace in a variety of financial and strategic positions. "Intel was an ideal place to work immediately following graduation; it allowed me to learn how a world-class high-tech manufacturing company operates," he says. "The finance rotation program gave me the opportunity to support various facets of the company, including IT, marketing and revenue."
A decade after receiving her undergraduate degree in electrical engineering at UC Davis, Donna Leever MBA 93 returned to campus to enroll in the Graduate School of Management. Two years later, she embarked on a career as a strategic planner and marketer at both startups and multinationals—including H-P, Agilent Technologies, Tektronix and TDK—with multiple successes in formulating and executing business strategies for sustainable growth.
Over the past two decades, Tracy Neal MBA 01 has "bounced back and forth between the beer industry and the tech industry. Some of my job changes have been impulsive, others reactive and some just out of my control," he admits. But there has been a clear and successful path to these job changes, which have resulted in a varied and rewarding career—one that has earned Neal the GSM Alumni Association's 2014 Distinguished Achievement Award.
The founder and CEO of Lamplighter Financial, Brian Woodall started his career as an entrepreneur, riding the dot-com roller coaster after earning a B.S. in commerce at the University of Virginia. "But then I had to get a real job," he says, "and went to work for two large consulting firms in internal corporate finance roles." He earned his CPA while with Grant Thornton's government consulting group, and then decided to go back to school for an MBA.
Mark Brooks grew up on dairy and fruit farms in California's Central Valley. One day he plans to return to his deep agricultural roots and operate a vineyard. But that's still a little down the line.
Julie Jensen grew up in Sacramento's Land Park neighborhood and studied economics as an undergraduate at UC Davis. After earning her master of administration at the Graduate School of Management in 1984, she was hired by HP in Roseville, Calif., as a financial analyst. "It was a great first job and taught me a lot about the importance of understanding changing business models and financials," she remembers. "I was fortunate to be in a growing division and moved into management very quickly, which expanded my skills—and created a lot of pressure on my family when my children were young.
The Sacramento Business Journal recently named Mac Clemmens MBA 07 one of "40 Under 40" superachievers in the Capital Region. Clemmens is founder and CEO of Digital Deployment, which he has grown into a multimillion-dollar company.
Todd Whitaker MBA 95 grew up in farm country near Lodi, in California's Central Valley. After high school he went west, attending UC Berkeley—where he studied economics and political science—and then spent five years selling computer and network equipment to government and corporate accounts. He wanted to stay in technology, but also wanted to "move upstream," so he applied to the Graduate School of Management with the goal of finding a career that would be more fulfilling. A summer internship at Intel led to a job offer and new insight.
Aimee Whaley MBA 01 began her career at Agilent Technologies 13 years ago, as a summer intern while an MBA student. Since then, she's had the opportunity to manage a number of different teams and programs, including Agilent's Corporate Social Responsibility Report and efforts to improve the global environmental-friendliness of the company's products. She's enjoyed growth as well as responsibility, rising from project associate positions to manager of worldwide teams, and today is Agilent's program manager for Restriction of Hazardous Substances.
Ken McGuire MBA 04 spent the first 15 years of his career in commercial lending, working up the ranks to national sales manager of small business lending for Wachovia Bank. Shortly after leaving Wachovia following the 2008 financial meltdown, he was named chief financial officer for Horizon West Healthcare—at the time, the largest privately held healthcare provider in the Sacramento region, with $250 million in revenue, 27 facilities and more than 3,000 employees.
Adam Lipman MBA 08 spent nearly 13 years at Genentech and then Roche with increasing levels of responsibility. During his time at Genentech, he completed the part-time MBA program in Sacramento. "It helped accelerate my journey into leadership and I fairly quickly transferred to corporate HQ," he says.
Anne Retterer's UC Davis MBA has proven a valuable passport to a rewarding global career. She embarked on her corporate journey with Osaka-based Takenaka—the world's largest construction R&D company—working as an accountant while continuing her education following a year in Japan.
UPDATE: Andrew Barkett is leaving his post as senior engineer at Facebook to bring his decade of experience in Silicon Valley to become the first-ever chief technology officer for the Republican National Committee.The June 4 announcement has stirred a whirlwind of media coverage, including the Huffington Post and Washington Post.Bark
Roger Halualani MBA 91 recently made a multi-year, $25,000 gift to support the Integrated Management Projects and Articulation and Critical Thinking (IMPACT) curriculum for MBA students.
A founding partner at the leading healthcare consulting firm, Epiphany Partners, Halualani assumes the GSM Alumni Association presidency on July 1. He shares what motivated his gift, reflections and highlights of his successful career—and his priorities for building the School's alumni community.
Gary Lew's career has enjoyed an interesting evolution. A political science major at UCLA, his first job after college was on the staff of U.S. Senator Pete Wilson. When Wilson was elected California's 36th governor in 1991, Lew followed him to the State Capitol in Sacramento. After four years in the governor's office, he decided to pursue a new path in business and joined Merrill Lynch's investment management group. He also determined to earn an MBA and enrolled in the Graduate School of Management in 1996.
With a degree in computer engineering from California State University, Sacramento, Tina Angell began her career at Hewlett-Packard, performing technical marketing in HP's Internet Printing & Imaging Division. Realizing the doors a UC Davis MBA would open, she enrolled in the Sacramento MBA program, and grew into progressively more responsible marketing positions at HP while she earned her degree in 1999.She continued with the company, spending six years in marketing communications as the worldwide sales tools manager in the ProCurve Networking Division, and then served as a produc
(Davis, Calif.) – With a joint goal of speeding the transfer of new technologies from the laboratory to the commercial marketplace, the UC Davis Graduate School of Management, Lawrence Livermore National Laboratory and Sandia National Laboratories have announced a new partnership for researchers to develop their entrepreneurial skills.
Agilent Technologies' Electronic Measurement Group is a $3.6 billion business that over the past decade has seen a dramatic shift in its customer base from U.S., and Western European customers to predominantly Asia-based customers. Today, the majority of the division's revenues are generated outside of the U.S., with an increasing concentration in China.
(Davis, CA) — The UC Davis Graduate School of Management's full-time MBA program has been ranked among the top six percent of AACSB International-accredited programs nationwide, according to U.S. News & World Report's latest graduate business school rankings released today.


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Since Demonoid got shut down I've been trying to find a decent private tracker to continue building my audio-book collection. If anyone could hit me up with an invite, that'd be super cool.
I think there were 4? Quick Looks in the entirety of last week. I'm really starting to think they must all have part-time jobs or something, it's getting ridiculous.
I was playing with a friend earlier and couldn't believe how much fun I was having with a fantasy mmo. At no point in the 3 hours we played did I find myself bored, or with a lack of interesting content to dive into.
Refusal to do more ER's at the same time as lame excuses about no games being released means I will not be resubbing.Live stuff is boring as hell, Quick Looks have become cynical and painful to watch.
This totally reminds me of Jeff's award winning Persona 4 : Arena review idea on the Bombcast."It was Monday, and my finger really hurt..."
http://www.youtube.com/watch?v=D4accneX_zg&feature=player_embeddedKorobeinki definately gives 1-1 a run for its money.


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Once upon a time, in a year far, far away (2013) there was a family of four who desperately wanted a kitten. ONE kitten. However, one day the weak, weak mother - who loves cute and fluffy things - melted at the animal shelter, and signed off on two darling 11-week old kittens: one was a grey/white tabby and the other a calico. How was she going to explain this one to her Hubby? Blaming it on poor math skills. That's the ticket. So unbeknownst to the weak mother, Calico cats are shy, ... [ Read More ]
WEIRD A*S MINDS: Greasy Criminals Flee
ST. PETERSBURG, Fla. (AP) - A truck containing 18 tons of Crisco sticks headed to a grocery store chain distribution center was stolen in a Florida city. St. Petersburg Police say that a tractor-trailer containing the 36,000 pounds of vegetable shortening was snatched Sunday morning. The truck was destined for a Publix distribution center in Lakeland. This is a clear case of a late-night, fried chicken run turned bad. Obviously, drug induced thieves were experiencing "the munchies," ... [ Read More ]
Bucket Lists, a Rodeo Clown and Baryshnikov
Typically, I write my Goofy Bucket List adventure every month - but not this time. Another bucket has consumed me. No, I'm not working as a rodeo clown and unable to escape. But that's not a bad idea for a future story. My oldest child often mentions her "bucket." As you can imagine, this is confusing. "Miss Susie filled my bucket today," she said beaming, as if she had swallowed a ray of sunshine. "You have buckets at school? I don't remember that being on your school supply list," I ... [ Read More ]
Effectively Teaching Children about STRANGER DANGER
The other day I heard a young grade schooler say to her mother, "I can't talk to them. They're a stranger." Initially, I thought what an excellent job that parent did educating her daughter; but then I quickly realized the mother had instructed her child to ask a store employee a question, who was only 3 feet away, yet the child was paralyzed. If all adults are the enemy, what are children to do when they need help in an emergency or are lost? WHO SHOULD KIDS TRUST? The ... [ Read More ]
A Child's Fear of Halloween is Debilitating for Parents Craving Chocolate
Once upon a time, there were children who hated Halloween. "Shut your mouth!" you exclaim? True story. "How can children not enjoy a holiday, where they are to dress up in costume and get free candy?!" you ask. Well, I'm not a professional holiday/candy researcher, despite my deep love of peanut brittle and candy cane fudge; but there actually are people who can help these kids overcome their fears. Several hundreds or tens of kids who are afraid of the dark and/or monsters can ... [ Read More ]
Old School Java Man is Daddy-O!
In middle school, the first "rock" concert I went to was The Manhattan Transfer. And…I went with my Dad. *insert laugh track* You might guess my father was the one convincing his tween-aged daughter into accompanying him to this Jazz concert, but you would be sorely mistaken. I begged him to go. No Aerosmith. Not Rick Springfield. Nary a Black Sabbath head banging experience. I wanted the best music I had ever heard…the fabulous four with impeccable harmonies. To ease your ... [ Read More ]
409 Foolproof Ways to Kill Household Wasps
Hum de dum de dum! What a beautiful day to read a book by the window in my favorite chair! BUZZZZZZZ. Buzz. Buzz-buzz-buzzzzzz. Please don't let that be a wasp! My husband isn't home and I'm gonna have to leave the house until it dies. Please, God, Puh-leeze!!! Make it disappear! FOR THE CHILDREN... Ever have an experience like this? All alone in your home with the dreaded, stinging bomber-of-doom? No knight in shining armor to save you by beheading the circling bastards? Makes me ... [ Read More ]
We Have a Winner of Jen Mann's Book, People I Want to Punch in the Throat…
Hey everyone who entered the contest, thanks so much for trying! Unfortunately, I only have one book to give out to one lucky person and that person is... Leah Craig I will get this to you in the mail shortly. I hope you enjoy it as much as I did. Stacey ... [ Read More ]
ASK Nurse Mommy Sharing How to Stop Kids From Peeing on the Rug
Nurse Mommy, I have a question and need some advice. My 3 year-old granddaughter enjoys peeing on her bedroom carpet. Sometimes it's more than once a day. And, one day last week, she drank all the milk in her cup, took her baby sister's bottle, poured it into her cup, and then peed in the bottle!!! Luckily, my daughter got in the room, just before she gave the bottle back to her sissy. She knows to go in the toilet. She's just being rotten!!! She's the middle child, with a brother two ... [ Read More ]
Anxiety Much? Spiders and Skeeters and Ticks, Oh, Crap!
Sometimes there are occasions that set an overly anxious parent into panic mode. Sound familiar? You can try to breathe through it or think logically; but somewhere down the road, the brain pathways have changed and different events can trigger the signs of panic. Some symptoms are a racing mind, increased heart rate, perspiration, diarrhea, nausea and/or the mothah of all evils…the PANIC ATTACK. If you haven't experienced one of these bastards, you are fortunate and might scoff at those ... [ Read More ]
There's No Whining in Grape Stomping
There it was. A full-bodied, agreeable red, with nice legs, a hint of unbalance and a spirituous finish. And that was just the grape stomping! The host for our autumn afternoon adventure was the BlueJacket Vineyard and Winery. It was their 5th annual "Sip, Stomp and Play." Included in our day pass was a grape stomp, wine tasting and other "farmish" festivities to raise money for their local Farmer's Market. We came there with open minds and empty glasses. The wine consumption was at ... [ Read More ]


text: Hello, this is a review of the Samurai Deeper Kyo TV series. I'll start with the graphics, and drawing style, the style of art was very good in my oppinion, it matched the manga well, and the glow graphics, and special effects and stuff liek that were very well done, for example the most used oen is when Kyo uses his Mumyo Jinpu Ryu. over all i give the graphics a perfect 5/5Now, I shall move onto the story, this is one of the two downfalls that this series has. The story, if you ahve never read the manga, is in fact an amazing story. BUT! if you ahve read the manga, and enjoyed it, prepare to eb somewhat disapointed. The anime strays very far from the manga's storyline, events similar to the manga occur but not in the same way that the manga's had happened. The storyline will keep you intrigued and fascinated, even if u have read the manga you'll be wondering whats gonna happen next. I was still disapointed in the fact that the anime strayed form the manga though so my final score for the story is a 3/5Now onto sound, the only thing keeping the sound category from a 1 is that all the backround soundeffects and music is awesome, (especially the acoustic guitar during flashbacks loved that). But why is it getting a two? the voice actors, admittedly the voice actors did very well, but i honestly don't think the casting director chose teh right voice actors for the show. (btw i'm talking american voice actors, i haven't watched it in japanese yet.) Honestly tho, some of them were just stupid, the guy who played tristan played Mika's father in like the 3rd episode that disapointed me, and the voice actor of Muramasa was dispointing too. All the other voice actors were all right, i'd say the only two that fit perfectly in my mind were Saizo and Sasuke, it was just a dispointing job. For kyo, they got the guy who does Yugi's voice on Yu-Gi-Oh, i was picturing more of a spike, for kyo, Yukimura's could have been better too, say maybe played by the guy who did Vashes voice in Trigun.The overall replay value of this series is good, but it really all depends on if you liek it or not, if u didn;'t dont watch it again, if u did watch it again lol so replay gets a 3/5 and overall i'd say teh series as a whole get's a 4 out of 5 for just being a good anime. thank you for your time n.n


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Yelawolf may not appear to be your stereotypical southern rapper, with his countless tattoos, long hair and skater steez, but the Alabama native is busy creating a buzz nonetheless. He released his first mixtape, Trunk Muzik, earlier this year, and signed to Interscope Records just last week. We decided to give him a break from… Read more »
Ah, the skinny jean. In the 20th century, it began with punk rockers. Then skaters, rocks bands like The Strokes, and women embraced this cut. Finally, the hipsters caught on, rocking their dirty skinnies with equally dirty white canvas kicks and vintage tees. The HipsterSoon after developed the "hopsters." Very similar to the hipster in… Read more »
Three months ago, Andre Berto had the biggest fight of his career in front of him. On January 30, Berto was set to face Shane Mosley in an opportunity to become one of the premier stars of the welterweight division. Then tragedy struck. A devastating 7.0 earthquake ravaged Bertos native Haiti, resulting in the death… Read more »
11:25PM EST: Roy Jones on the way to the ring, very stoic and serious to Snoop's "I Wanna Rock." Cracks a small smile as he hears it from his fans. 11:32PM: Hopkins comes to the ring in his trademark Executioner hood. Trainer Nazim Richardson is behind him looking unconcerned and relaxed popping gum. Bernard has… Read more »
DrJays.com has teamed up with LRG to present "We Are The Champions"a special set including two tees, a cinch backpack and mini basketball. We're representing the four teams with the most championships in the NBA: Boston Celtics, San Antonio Spurs, Los Angeles Lakers and Chicago Bulls. Chitown by LRG The Alamo by LRGWhen you purchase… Read more »
Singer, song writer and part-time blogger Esthero recently had this custom chain made by GoodWoodNYC. Talk about a statement maker! I know T-Pain laid his $400,000 "Big Ass Chain" to rest, but Esthero is taking it to new levels. The Brooklyn-based GoodWoodNYC brand is known for its innovative custom-made wooden jewelry and accessories. Juelz SantanaYou… Read more »
17 years is a long time to wait for anything, let alone revenge on a hated rival. Since 1993, Bernard Hopkins has brooded over his decision loss to Roy Jones, Jr. In 2002 talks of a rematch collapsed over what Hopkins viewed as financial disrespect, when Jones only offered him a 60-40 split. The ensuring… Read more »
If you could raid any hip hop artist's sneaker collection, whose would it be? Would it be Jay-Z, who mixes it up with new brands like Radii, and classic Nike? Perhaps it's Chris Brown, who favors a skater steez with Supra, Vans, and lots of vibrant Nike kicks. How about the colorful Lil Wayne, who… Read more »
Knockout Nation: Abraham vs. Dirrell Tonight! Erik Morales Returns, Green-Ward, Guzman Overweight Again! David Haye Next for the Klitschkos?
Can Dirrell Beat Abraham? Tonight American Andre Dirrell (18-1, 13 KOs) will attempt to get his first win in the Super Six over current tournament leader Arthur Abraham (31-0, 25 KOs). Abraham came out with guns blazing in his first bout by viciously knocking out Jermain Taylor in the 12th round. That crushing defeat made… Read more »
That's Lil Duval above, who clowned one of our "10 Worst Chains In Hip Hop" at last year's Hot107.9 Birthday Bash in Atlanta. While this particular piece has been laid to rest, other gaudy creations are still being flaunted by popular rappers. Check out the jewelry that gets a "hell no," and let's see if… Read more »
Curren$y, Mickey Factz, Wiz Khalifah and others were repping hard for Clipse's clothing line Play Cloths during South by Southwest 2010 in Austin, TX last week. Press play below to check out video of the rappers repping the brand. Oh, and you're not sick of SXSW coverage yet, right? We hope not! Click here to see… Read more »
After creating GoldSpun, the contemporary apparel brand based on raw materials, creative director Marck Marcellus moved his talents into footwear and developed GodSpeed. The GodSpeed philosophy is simple: "Change The World We Walk On," and the first collection is based on the mathematical concept of Phi. Phi, also known as the golden ratio, is a… Read more »
We saw "Harem" pants make their way into women's wardrobes last year, with their low, baggy crotches and tapered legs. Are you ready for your dude to cop this look, too? During the recent slew of fashion shows, runways from Yves St. Laurent to Dolce&Gabbana presented these pants in materials as varied as fleece, denim… Read more »
Knockout Nation: The Blood Testing for Mayweather-Mosley Detailed, Where Does This Leave Manny Pacquiao?
Roughly two months ago, the biggest fight in boxing history did not happen due to arguments regarding the testing for performance enhancing drugs. And now, the fallout from that decision continues to affect and possibly change the future of boxing as we know it. Over the past week, representatives for Floyd Mayweather, Shane Mosley, and Golden… Read more »
Yesterday, I got a chance to check out Kerin Rose's new A-Morir eyewear collection with DJPremium.com buyer, Jamila. The appointment took place in Kerin's eccentric Manhattan apartment, where she currently creates her edgy sunglasses by hand. As we featured in this previous post, Kerin Rose has quickly become a must-have for the hottest ladies in… Read more »