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(231 quotes found)
"An entrepreneur assumes the risk and is dedicated and committed to the success of whatever he or she undertakes."
Victor Kiam
"You may be a redneck if . . . you think you are an entrepreneur because of the "Dirt for Sale" sign in the front yard."
Jeff Foxworthy
"I wanted to be an editor or a journalist, I wasn't really interested in being an entrepreneur, but I soon found I had to become an entrepreneur in order to keep my magazine going."
Richard Branson
"I often find that entrepreneurs think my theory is great. My interpretation is that they are people who weren't considered that smart in school because they didn't have good notation skills-you know, moving little symbols around."
Howard Gardner
"Business has been so drab, all grey suits and cufflinks. But there's a whole new generation of entrepreneurs starting to make it fun."
Simon Woodroffe
"He's a serial entrepreneur. Somebody stop him before he makes a killing again."
Carl Zetie
"Anybody that believes they can get any product from an entrepreneur or the creator of artistic products for free is either stoned, drunk or brain-dead or just stupid,"
Ted Nugent
"Most entrepreneurs are merely technicians with an entrepreneurial seizure. Most entrepreneurs fail because you are working IN your business rather than ON your business."
Michael Gerber
"are entrepreneurs born or made?"
Brigham Young
"A lot of entrepreneurs are leading with the names of where they were, establishing some initial credibility."
Brian Vincent


text:
Steelers Hosting Baylor RB Lache Seastrunk, Mississippi WR Donte Moncrief For Pre Draft Visits
By Dave Bryan on April 1, 2014 at 11:42 am@SteelersDepotThe Pittsburgh Steelers have already scheduled several players for pre draft visits and now we are starting to hear about some of those visits actually taking place.
On Tuesday, Bob Labriola of Steelers Digest reports that Baylor running back Lache Seastrunk and Mississippi wide receiver Donte Moncrief are both in Pittsburgh visiting with the Steelers.
Seastrunk rushed for 1177 yards and 11 touchdowns on 158 attempts last season and many view him as a third or fourth round selection.
Moncrief, who many believe will be drafted in the second or third round, caught 59 passes for 938 yards and six touchdowns last season.
The Steelers are allowed 30 out-of-area pre draft visitors prior to draft day.
You may also like...
- shawn
If we draft a RB in the 3rd or 4th round this year … heads should roll !!
- srdan
unless he is an exceptional KR, better than LB
- taztroy43
We should draft dri archer in the 5th! We already have blunt…so a high pick on a rb is out of the question imo….
- Tanner Blackman
We only have running backs with initials LB
- shawn
i like archer … 5th comp pick it is !
- blackandgoldBullion
Hey, Dave. If the "Steelers are allowed 30 out of area pre draft visits", could you please let us know what technically is considered inside their area. And I am assuming that there is no limit to visits of athletes in their area. so what am I getting at? Which universities would be within the area?
- Blue
Mike Evans will fall into our lap
- Ernest
I was wondering the same thing? Is it based by radial distance or state?
- SumnerYoung
The Belldozer and the Blountdozer. We need to add some lightning to that two-headed thunder monster!!
- SteelersDepot
This should help, a little http://profootballtalk.nbcsports.com/2011/04/05/breaking-down-the-rules-regarding-pre-draft-rookie-visits/
- steeltown
I really like this Seastrunk kid, but he doesn't have any added versatility, not much receiving or kick return experience
- blackandgoldBullion
Interesting, thanks. The bigger the Metro area, the better. The bigger the population the better.
Anyway, what I find interesting is the fact that the Steelers since last year have been drafting an inordinate amount of captains, or students that have done very well in their studies. Add to that they seem to be shying away from any player who has a checkered past. I noticed that last year. That's something that we should consider in how they make their selections in the draft this year.
- Ernest
Just got this done on a mock simulator:
1.20 – CB,Kyle Fuller (trade back)
1.29 – WR,Kelvin Benjamin (trade up)
3rdC – DT,Daquan Jones
4th – ILB,Yawin Smallwood
5th – DE,Brent Urban
5thC – CB,Aaron Colvin
6th – TE,Xavier Grimble
6thC – WR,Jalen Saunders
7th – OLB Aaron Lynch.Evans, Gilbert, and Dennard were gone at 15. I used the extra 3rd round pick from the trade back plus our 2.46 to move back into first round. Not exactly sure about the prospect rankings, I think they used cbssports but it would be nice if it turned out like that.
- CuldesacBill
If these draft picks would turn out, I'd be a happy man. I'm not a big fan of Jones in the 3rd round, but everything else there would help them considerably in 2014.
- blackandgoldBullion
Ernest , you're thinking along the same lines as me. Trading down with the 49ers might be the best option as they have no use for all the 12 picks they currently have. I would come up with several different players, but the 1st 2 would be great, and I also would like Colvin, as he could be a 2015 starter. By then the Steelers would probably be much closer to at least a playoff caliber team.
- email@example.com
Ernest, interesting…….. Was Ebron available at 15?
- email@example.com
Hey, Bill we need to draft a TRUE NT this year and Jones fits the bill with his size/strength even though he was more of a 4-3 DT in college. Shift McClendon to DE and our DL problems (at least for starting DL) are fixed.
- Guest
I dont remember but I was going based on the draft needs poll. I tried to play a delicate balance in what everyone feels as needs with BPA. CB was top priority followed by WR so I went with those positions first.
- Ernest
I dont remember. I was basing this off the draft needs poll. I tried to play a delicate balance in what everyone feels as needs with BPA. CB was top priority followed by WR so I went with those positions first.
- StrengthOfVictory
I know the Steelers need to be ready for multiple scenarios, but Moncrief (to me) is one of those "best of the rest" type of guys, and (personally), I hope this team gets someone ranked at Jordan Matthews' level or higher.
I'm beginning to think this is wishful thinking, but I hope he falls in our lap.
- Biophys
I almost love your mock. The biggest changes that i would make would be to keep the 3rd rd pick that you acquired by trade. Then I would also try to trade back in the 2nd rd as well and take Moncrief. IMHO, ( Moncrief + a 3rd rd pick + a 4th rd pick ) > Benjamin. We might land C.J. Fiedorowicz or Dri Archer or Shayne Shov with one of those extra picks.
Although, the thought of having Benjamin in the Red Zone does make me salivate a little.
- Biophys
I've watched both Matthews and Moncrief play for the past several years. Matthews, IMHO, is one of the safest options at WR in this draft. He join almost any NFL team and start as the #2 WR from day one. And he would probably still be your #2 WR in 8 years. He would be a perfect compliment to AB.
Moncrief, on the other hand, if more likely to start out as the #3 WR on any team. But after 2 seasons, I see him vying for the #1 spot. He has a bit more upside than Matthews because of his ability to make people miss in open field, but he will require a bit more coaching than Matthews.
They both have good hands, good speed, and good length. I'd love for either one of them to suit up in black and gold.
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Scientists Identify Antibodies That Block Human and Animal SARS Viruses
...eriments on a mouse model to test the neutralizing activity of the antibodies. The researchers say that the new findings are important because animal strains of the virus may be capable of triggering a future human outbreak. "This study is important because the viral strain that caused the outbreak in peo...Rosehips may Be an Effective Alternative for Rheumatoid Arthritis
...ening doors, and cutting meat. After six months, activity levels improved by 20 to 25 percent for those taking LitoZin. The number of joints causing them pain and discomfort fell by 40 percent, but did not change for patients treated conventionally without the rose-hip supplement. Generally, the overall t...Lost Sleep can Never Be Compensated for
... researchers monitored their brain wave and muscle activity patterns in order to precisely quantify sleep-wake patterns. The animals compensated for the sleep loss by increasing the depth of sleep after the first day, which is indicative of a homeostatic response. But on the subsequent days of sleep loss, t...Translating Structure into Function
...e that fits the enzymes active site will block its activity just what many promising drugs do. The strategy works well for one kind of drug discovery -- finding molecules to fit in the active site and physically block enzyme action. But the research team sought to divine from an enzymes structure just what...Embryo Protection Law in Germany
...he new reimbursement rules were implemented, total activity dropped by nearly 50 per cent to 60,425. Significantly, this was a persistent effect because the number of cycles remained at this lower level in 2005. Prof Nyboe Andersen, of Rigshospitalet, Copenhagen, Denmark, was presenting data on behalf of th...Humans are Gobbling Up a Quarter of Nature's Resources, Reveals Study
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... of laboratory experiments designed to enhance the activity of our experimental immune stimulating approaches," said Bramson, an associate professor in the Department of Pathology and Molecular Medicine and principal investigator on the project. "Harnessing the power of the immune system to fight cancer he...Smashing Times for Stressed Spaniards
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... public hearing on the project. He said volcanic activity has increased in recent weeks with the frequency of volcanic quakes rising and with the crater island showing signs of bulging. The environment and natural resources department said, amid protests from Talisay residents, that the building of viewin...Insight Into Neural Stem Cells Has Implications For Designing Therapies
...e raises the possibility, he says, that the cells' activity is regionally modulated in order to regulate the production of different types of neurons. "This may provide a mechanism for the brain to dynamically fine tune the olfactory bulb circuitry, raising a fascinating basic question about neuronal replacem...EpiCept Accelerates Development of Phase I Clinical Study for Cancer
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... root of depression. They studied the electrical activity of still-active slices of the hippocampus section ...using high-speed high-resolution cameras to record activity in brain neurons in real time. According to Deisseroth, rat brains show similar depression symptom...Autophagy may Lead to Heart Disease
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...these rats, they found an alteration in electrical activity flow through the brain that could be corrected by human antidepressants. The extent that the signal spread through the brain sample was diminished in the "depressed" rats, a crucial finding that would not be apparent with other experimental methods, ...Parkinsons Disease Mechanism Identified
...earchers discovered evidence that the loss of Prx2 activity also plays a role in human PD. They found reduced Prx2 activity in brain tissue from PD patients. These findings provide a mechanistic link of how a mitochondrial...Higher Rates of Trampoline Injuries
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Some companies outsource the production of their active pharmaceutical ingredient (API) and keep later stages of the supply chain, such as packaging and distribution, in house. Others retain API or drug substance manufacturing, but partner for subsequent activities. Still others partner for multiple steps in the supply chain, or the entire supply chain. While the outsourcing configuration is specific to the characteristics and business objectives of each company, its operating model and technology, several common themes tend to underlie the "business case" for outsourcing.
Many smaller development-stage companies, which lack expertise in manufacturing and supply, prefer to focus their capital and resources on areas they view as true differentiators, such as discovery or marketing. By maintaining a strategic focus on these core activities, they can narrow their capital requirements.
Deciding whether to outsource requires consideration of many variables and should follow a structured approach that evaluates a company's: existing skills and capabilities strategic objectives maturity of the technology or capability in question competitive environment
The second step is to analyze the near-term operational, financial, and competitive realities to justify the preferred direction or select another. Outcomes of the overall assessment include both near and long-term strategies that establish principles and priorities of that particular operational capability.
A company may decide to outsource an existing capability because it will no longer be strategic in the future, or to temporarily outsource to reduce internal risk during launch, but bringing those capabilities in-house later.
Changes in the country's political landscape may affect the pharmaceutical industry market in the future.
The author discusses the various ways in which a quality-by-design program can enhance the extractable and leachable assessment of a drug product.
The use of commercially available media to achieve high titer in early process development is discussed.
The fast growth of the global biopharmaceutical market has prompted global pharmaceutical and biotechnology companies to increase their R&D investment in biologics.
The draft guidance contains policies for drugs that are processed with additional manufacturing steps such as remixing, dilution, and repackaging.
The agency releases five draft guidance documents related to drug compounding and repackaging.
Market forces may limit the success of CMOs.
FDA announced that it would postpone a meeting that would be critical for the advancement of Celltrion's Remicade biosimilar in the US.
Drug shortages are declining, but they're still a serious concern for regulatory authorities, policy makers, and bio/pharmaceutical manufacturers.
The company voluntarily recalls product due to FDA observations of potential sterility problems.
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TNT's Sager Receives Warm Welcome Back NFL Panthers Add Private Stadium Club Cowboys' Jones Asks To Stay Off Witness Stand Eight Challengers Vying For NFLPA Exec Dir Job ESPN's "Mike & Mike" Celebrates 15 Years NASCAR Atlanta Race Sees Strong Audience ESPN Paying $7-9M For Hockey World Cup NFL Draft Will Utilize Chicago's Grant Park Carson NFL Backers File For Ballot At Least Seven To Run For NFLPA Exec Dir
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SBD/November 5, 2013/Media
ESPN Sees 9% Overnight Rating Uptick For Week 9 "Monday Night Football"
Published November 5, 2013
BEING FLEXIBLE: ADWEEK's Anthony Crupi wrote under the header, "NFL Flex Schedule A Godsend For NBC." Next week's Cowboys-Saints matchup "features two first-place teams." Meanwhile, the league has "optimized the first week of the flex schedule to NBC's advantage, shifting the Nov. 17 Chiefs-Broncos game from CBS' late national broadcast to Sunday prime." The 7-1 Broncos and QB Peyton Manning "are huge draws, and the league has ensured that the team gets as much national exposure as is humanly possible." Fans also should "look for the NFL to invoke its flex powers in subsequent weeks, as it will want to showcase games" like Seahawks-49ers and Packers-Cowboys in "favor of the previously-scheduled" Falcons-Packers and Bengals-Steelers games on Dec. 8 and Dec. 15. The 2-6 Falcons are "all but out of contention." Meanwhile, the "once powerful Steelers franchise is mired in last place" in the AFC North. CBS and Fox have the "right to protect five games each, but league politics often plays a part in getting the networks to relax their grip on their national matchups in favor of giving the week's best pairing a prime time showcase." CBS originally had protected Chiefs-Broncos, but it "agreed to make a one-time accommodation at the NFL's request" (ADWEEK.com, 11/4). In N.Y., Andrea Morabito noted AMC's "The Walking Dead" outdrew NBC's Colts-Texans "SNF" matchup among adults 18-49, "the demographic preferred by advertisers." "The Walking Dead" averaged 8.7 million viewers among adults 18-49 in the 9:00pm ET hour-long window, topping the 8.1 million viewers who watched Colts-Texans (N.Y. POST, 11/5).
PATRIOT GAMES: CBS' telecast of Steelers-Patriots in the national window on Sunday averaged a 40.3 rating in the Boston market, the highest rating of the '13 NFL season to date. The only sporting event to receive a higher local rating was Red Sox-Cardinals World Series Game 6. Sunday's rating marks a 15% increase from the season's previous high, a 35.1 rating for Saints-Patriots in Week 6. It also marks the first time this season that a Patriots game has drawn a rating higher than 40 in the Boston market (Patriots).
ON THE MIKE: ESPN "MNF" play-by-play announcer Mike Tirico said of color analyst Jon Gruden, "I thought I knew something about football before I met Jon. Now I realize I had no clue. The five-year masters program that he's put me through is a degree that I'm second-proudest to have earned. ... I don't see what Jon sees, but he has taught me what's important -- line play, safeties -- to look for patterns in games as you watch them." Meanwhile, Tirico said of former "MNF" analyst Ron Jaworski being reassigned, "Still a bummer. No one has ever been in a room with Jaws and not had a good time" (JSONLINE.com, 11/2).
BLACK HOLE SUN: In L.A., Joe Flint wrote there is "a lot of confusion out there about what exactly the blackout rule is, how it works and what its removal would mean for both fans and the media." What the FCC's rule "does is prohibit a cable or satellite operator from circumventing those agreements between sports leagues and TV stations by importing a distant signal of a game that should be blacked out." This means that "getting rid of the blackout rule wouldn't mean the local station could suddenly show a game that wasn't sold out." It means a pay-TV distributor "could show it no matter how mad the league or local rights holder gets" (LATIMES.com, 11/4).


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- Say, T. 1835. Descriptions of new North American Hymenoptera, and observations on some already described. Boston Journal of Natural History. 1(3):210-305.
- Yu D.S.K. (2013). Taxapad Ichneumonoidea (version May 2009). In: Species 2000 & ITIS Catalogue of Life, 11th March 2013 (Roskov Y., Kunze T., Paglinawan L., Orrell T., Nicolson D., Culham A., Bailly N., Kirk P., Bourgoin T., Baillargeon G., Hernandez F., De Wever A., eds). Digital resource at www.catalogueoflife.org/col/. Species 2000: Reading, UK.
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Item: 134409 Model: 3117-01
Adesso® 62 1/2" Stewart Shelf floor lamp with black finish features on/off pull chain switch and 11 1/2" dia base. Lamp uses 150 W incandescent or equivalent CFL bulbs.
Bring a modern touch to your indoor space with the Adesso Stewart floor lamp. More than just an attractive lighting option, the lamp also features two shelves and a base for displaying collectibles or other small objects. At 62.5 inches high, it will be an impressive presence in your office, reception area, or living room. The pull-chain switch lets you easily turn the light on and off.
Lamp Light Source | Incandescent/CFL |
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Need more help? Get advice from your Network REVIEW SNAPSHOT® by PowerReviewsAdesso® 3117-01 Stewart Shelf Floor Lamp, 1 x 150 W, Black Reviewed by 2 customers Sort by Displaying reviews 1-2 11/13/2014 (1 of 1 customers found this review helpful) Flimsy construction Comments about Adesso® 3117-01 Stewart Shelf Floor Lamp, 1 x 150 W, Black: This lamp looks good online, but the reality is that it's a flimsy piece of junk. The pictures-only assembly instructions are next to useless. I pretty much had to figure out how to assemble it myself. The lamp is unstable, wobbly, because of the poorly conceived construction. The materials are cheap. There is a serious risk of overtightening the components and losing what little stability it has. This lamp looks good in a corner where it won't be bothered. Storing things on it is risky, bedcause the lamp falls over easily. Even if you put weight the the bottom shelf to keep it from falling over, you could still easily break it at any of the weak points (where the rods connect to the shelves). Would you recommend this product? No, I would not recommend this to a friend (1 of 1 customers found this review helpful) Was this review helpful? Yes / No - You may also flag this review 2/20/2013 (1 of 1 customers found this review helpful) Perfect Lighting By JenniMiki from Asheville, NC About Me Midrange Shopper Pros
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Comments about Adesso® 3117-01 Stewart Shelf Floor Lamp, 1 x 150 W, Black: I love this lamp. It has a great design and fits into the small space I needed to light perfectly. I'm able to add some plants to the shelves, which makes it look more homey here at the office. I would like to get another for my reception area. The only issue I had was that the instructions were all pictures, sometimes unclear, so I had to re-do the top part a couple of times. The pull chain goes through a small hole, and I couldn't see that from the instructions, but I figured it out. I will have to remove everything from the shelves to change the bulb, so that will be a pain, but worth it. Finally, the instuctions state that you may use a 150 watt bulb, but NOT a 3-way bulb. I can't find a 150 watt bulb that ISN'T a 3-way, but the 100 watt bulb is plenty. HIGHLY recommend. Would you recommend this product? Yes, I would recommend this to a friend (1 of 1 customers found this review helpful) Was this review helpful? Yes / No - You may also flag this review Displaying reviews 1-2 |
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Publishers Weekly
This nonfiction graphic novel gives the history of three early 20th-century magicians and the invention of the standard levitation trick. It's claimed that "Entranced Fakir," or "The Levitation of the Princess of Karnak" came from India, but in reality it was stolen from European magician John Neville Maskelyne by American Harry Kellar, who took it back to the States. Years later, it was passed on to Howard Thurston, who had "the voice and bearing of a preacher with the manner of a carnival barker." (Kellar notes that the two professions are "not so different.") The art is lively with nice Georgian and Jazz Age touches, especially in face shots that resemble old, hypnotic-eyed daguerreotypes of mesmerists in frock coats. It's all good fun, but the story never finds its heart, only touching on the obsessive control the great traveling magicians must have had, and their life on the road. The hard economics they faced comes through splendidly, however. To perform, they had to look like gentlemen. To survive, they had to act like cutthroat rogues. The story contains two revelations: one is the diagram explaining the trick. The other is the revelation that even when audience members are quietly shown how it works, they don't tell.(July)
Copyright 2007 Reed Business Information


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5 of 6 people found the following review helpful
This review is from: My Last Empress: A Novel (Hardcover)
Vine Customer Review of Free Product (What's this?)
I guess I expected some poetry, but poetry with such a dislikeable narrator is, to say the least, on the eccentric side. Nevertheless, I found myself engrossed. This is a novel of obsession with a ghost and a bit Lolita-like. If the eroticesm doesn't bother you, you will probably enjoy this, disgusting as the narrator is.
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A warm red, slightly raised, rash appeared on my shin three days ago.Posted by Windy The first one has faded, but a couple more appeared below it. Now there are two on the underside of my upper arm as well. There are no open wounds near or on any of them. They are warm to the touch and hurt like a bruise when touched. What could it be? |
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#206355 - 07/05/12 11:54 AM Re: grandma's lodgings [Re: Jackie]
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Loc: R'lyeh at first I was quite confused because it seemed like zmjezhd was saying that because some sentence can't be verified as true, it therefore isn't grammatical.
That is the opposite of what I was trying to say. Most linguists separate semantics and logic from grammar. For this group of people there can be perfectly grammatical sentences, e.g., the example sin the OP. Though they be meaningless for semantic or logical reasons. Again, I apologize for the confusion._________________________
Ceci n'est pas un seing.
#206376 - 07/07/12 10:14 PM Re: grandma's lodgings [Re: zmjezhd]
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Reif Larsen waits 200 pages before betraying his literary lineage by using the phrase "gravity's rainbow." For in his sprawling, pyrotechnic second novel, I Am Radar, one is never far from Pynchon's masterpiece, that once-groundbreaking combination of adolescent hilarity and theoretical physics. The authors share a soaring erudition and ambition—evidenced by the length and ostentation of their books. But where Pynchon's main theme might be a paranoiac fear of annihilation and conspiracy, Larsen's seems to be an affirmation of the pathetic randomness of life. It's telling that his previous book, The Selected Works of T.S. Spivet, was made into a film by the director of Amélie, and his new release resembles the joyful, madcap creations of Wes Anderson.
In St. Augustine's Confessions (one of the first spiritual memoirs), he famously prayed "Lord, make me good, but not yet." In his powerful, visceral new memoir, celebrity journalist Kevin Sessums, like a modern St. Augustine, testifies to the life-threatening pull between carnality and spirituality in his own life.
Families come in all forms. Ame Dyckman's new picture book, illustrated by Zachariah OHora, is all about the most unlikely new family member for a bunny family of three. They arrive home one day, surprised to find a bundle on their front stoop—and it's none other than a baby wolf.
Crime fiction groupies can usually form a pretty quick mental picture of the cop, PI or little old lady detective in any new mystery novel, and that take remains, embedded in the reader's imagination, for the duration of the story.
When Mimi Baird was 6 years old, her father, prominent Boston dermatologist Perry Baird, didn't come home. In that moment, Baird effectively disappeared forever from his daughter's life, for her mother told her only that he was "away." Baird saw her father once in the 15 years between his disappearance and his death in 1959.
There it is, right at the beginning of the rules pamphlet included with our family's well-worn Monopoly game. "In 1934, Charles B. Darrow of Germantown, Pennsylvania, presented a game called Monopoly to the executives of Parker Brothers." Sounds simple enough. But as Mary Pilon shows in The Monopolists: Obsession, Fury, and the Scandal Behind the World's Favorite Board Game, the road to fame for Monopoly was circuitous.
It's a glad thing when a reader encounters a character so compelling that you want to punch him in the nose. Such abhorrence—it's not really hatred—can be as pleasurable in its own way as love. Such is the aggravation caused by Jonas Karlsson's weird, insufferably arrogant, not quite neuro-normal protagonist in the crisp, novella-length book The Room.
When 22-year-old Alice becomes pregnant out of wedlock in the early 1930s, both she and her family fear disgrace. Her mother sends her from London to the Gloucestershire countryside to await the baby's birth at a place called Fiercombe Manor, after which she will give the baby to an orphanage. Her mother's old friend, Mrs. Jelphs, is the housekeeper at the empty manor, and she promises to keep watch over Alice, who has concocted a cover story of a recently deceased husband.
The great Richard Price (Clockers, Lush Life) dons a new literary persona as Harry Brandt for this crackling thriller. Haunted NYPD Detective Billy Graves' very name suggests not only his bleak working hours but also a death that landed him on the, well, graveyard shift.
There's something irresistible about a boarding school novel: the picturesque grounds; the tight-knit community of teachers and students and staff; the routine of seminars, lacrosse games and chapel; the inevitable romances that bud in such an insular world. In The Half Brother, her second novel after 2010's sensual The Swimming Pool, Holly LeCraw has created an appealing setting in the Abbott School, a campus at the top of a ridge in north Massachusetts where azaleas and cherry blossoms surround the stone and clapboard buildings, and the grass almost shimmers with mist.


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SPTLC1On this page:
Reviewed December 2009
What is the official name of the SPTLC1 gene?The official name of this gene is "serine palmitoyltransferase, long chain base subunit 1." SPTLC1 is the gene's official symbol. The SPTLC1 gene is also known by other names, listed below. Read more about gene names and symbols on the About page. What is the normal function of the SPTLC1 gene?The SPTLC1 gene provides instructions for making one part (subunit) of an enzyme called serine palmitoyltransferase (SPT). The SPT enzyme is involved in making certain fats called sphingolipids. Sphingolipids are important components of cell membranes and play a role in many cell functions. The SPT enzyme, which is made up of three subunits, initiates the first step of sphingolipid production. Specifically, the enzyme combines the molecules serine and palmitoyl CoA to form a molecule called ketodihydrosphingosine. A series of additional chemical reactions produce sphingolipids. Within the cell, the SPT enzyme is mainly found on the endoplasmic reticulum, which is a structure involved in protein processing and transport. How are changes in the SPTLC1 gene related to health conditions?
Where is the SPTLC1 gene located?Cytogenetic Location: 9q22.2 Molecular Location on chromosome 9: base pairs 92,031,133 to 92,115,473 The SPTLC1 gene is located on the long (q) arm of chromosome 9 at position 22.2. More precisely, the SPTLC1 gene is located from base pair 92,031,133 to base pair 92,115,473 on chromosome 9. See How do geneticists indicate the location of a gene? in the Handbook. Where can I find additional information about SPTLC1?You and your healthcare professional may find the following resources about SPTLC1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the SPTLC1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook. Where can I find general information about genes?The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful. What glossary definitions help with understanding SPTLC1?acids ; amino acid ; cell ; CoA ; cysteine ; endoplasmic reticulum ; enzyme ; gene ; hereditary ; molecule ; mutation ; nerve cell ; neuropathy ; protein ; sensory neuropathy ; serine ; subunit ; toxic ; transferase ; tryptophan You may find definitions for these and many other terms in the Genetics Home Reference Glossary. See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook. |


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Results 1 to 13 of 13
Thread: Workshops as Promotional Vehicle
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December 21st, 2009, 03:37 PM #1
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Workshops as Promotional Vehicle
Fung Koo, in a private message, asked me to expand on the perceived value of workshops online and off as a vehicle for self-promotion.
Here's what I've seen, in both my own experience and in that of other writers I know. In general, teaching writing is not a good tool for promoting one's own fiction writing (obviously, if you're using a textbook you wrote on writing, that nonfiction book will pick up sales.) That's because people who take workshops are there to learn to write their own publishable books, not to find a new writer to read.
This is really clear in workshops that aren't part of conventions, like Odyssey, Clarion, Sycamore Hill, Viable Paradise, etc. Someone who comes to those has one overriding goal--learning to write well enough to get published. They may come to a particular workshop because they already admire one of the instructor-writers (and hope the success will rub off or that writer will have some tips or some connections) or because of the workshop's reputation for having its students get published. I know people who have taught at some of these, and I taught at Viable Paradise its first year--and if their students care about the instructor's work, they've already read it. If they don't, they're so focused on their own desire to get published that unless the instructor pushes his/her own work as part of the instruction, there's no discerniable interest in sales.
At SF conventions, the results and the analysis are more mixed. Those who teach at convention workshops--or go on panels aimed at unpublished writers--are also available in other venues--usually they're also on non-writing-track panels, and they're interacting with fans (some of whom may have attended the workshop or writing panel.) If a good number of that writer's work sells in the dealer's room during the convention, it's possible (but not certain) that the workshop and writing panels brought in a few sales. However, what I've seen of that venue suggests that the bulk of the writing sales (when not mostly people who came to that convention to buy signed copies of that writer's work) come from being interesting/witty on non-writing panels and from interacting directly with people elsewhere in the convention. Those who come to the convention for the writing workshop and the writing panels are, once again, focused on finding a way to get their work published. They are as apt to be annoyed to angry with one of the instructors for telling them what they don't want to know ("That story is not ready for submission--fix this, this, and that") as eager to read the instructor's fiction.
Sadly, many people who go to workshops and attend writing-track panels are not willing to hear what they don't want to hear. They have very fixed ideas about what it takes to get published, what the "hidden truth" is, etc. I sat beside Anne McCaffrey at a long panel on getting started in writing one time, and she gave a ton of valuable advice. At the end, one of the attendees buttonholed her on her way out and said "I know you have to say all that to everyone else, your publisher probably makes you, but what's the real secret to getting published??? I won't tell anyone else..." This sort of attitude--that there are all sorts of conspiracies and secret handshakes and so on--means that a lot of people come away disappointed and upset--and not in the mood to buy the instructors' books, if they weren't already doing so.
Where workshops do have a promotional effect is in getting gigs for more workshops. That's especially true for those with advanced college degrees, especially doctorates in Fine Arts or English, but also for those with an MFA. If someone has taught at a prestigious workshop, both more workshop gigs and even academic appointments may follow. As a sideline or even main source of income, teaching workshops (for pay, of course) and teaching creative writing at colleges can supplement income from fiction. However, odd as it seems, this doesn't necessarily lead to more fiction sales. I know people whose fiction-writing career has slid downward (rather than climbing) although their workshop-teaching and academic-appearances have increased. One reason (other than student annoyance with instructors) might be that being the instructor for a residential workshop, as the prestigious ones are, is a heckuva lot of work. You have to read all the manuscripts; you have to prepare detailed critiques; you engage with the students every day, hours a day. You have to bend your mind to someone else's vision (every other student's vision) so that your comments make sense to that person in light of what they were trying to do. For some of us, it takes time afterward to wash your brain clean of those other influences, and get back to your own work with your own focus. Do that too often, or too long, and it's a real impediment to your own work.
Online workshops and posts on writing, as I said before, have a completely untested effect on book sales. I suspect (but can't prove) that they're no more effective than non-internet workshops in producing sales of the instructors' work. After all, that's not their purpose--their purpose is to help the students get published. That's how their success is measured.
There's a further complication: some really good writers are lousy teachers (and if they attempt it, they alienate more than the usual percentage of their students) and some really good writing teachers are not that good at writing fiction (so any student who is tempted to buy the instructor's novel reads a few pages and wonders if the instructor ever followed his/her own advice...) But I think the big gap that results in few sales comingfrom teaching writing is that the students aren't there to buy the instructor's books--they want his/her expertise. (Or they don't, and complain about it after they get it.)
An exception that isn't really is the writer's appearance at a university when the university has chosen a book as the "community reading"--and has thus forced faculty and students to read it. But those sales were made before the writer appears...they are not contingent on people deciding, after a writing workshop, to buy the writer's fiction. And the appearance isn't usually a writing course of any kind, but specific to a given book. Some books are included in the syllabus for genre fiction courses (lucky the writer to whom this happens!!!)--but again, that's not self-promotion by the writer.
So: To promote your fiction, you do personal appearances, you go to bookstores and sign shelf stock, you build a website and have a blog. If you can do it without getting in flamewars, you go to other sites and hang out and try to sound interesting enough that someone might--possibly--check out one of your books, without talking so much about your books that it annoys everyone. Some people have e-newsletters; some people carry around freebies (other than business cards) such as pens or bookmarks. When people ask what you do, you say you're a writer (and then endure all the humiliating questions they ask...sigh. "Could I read everything you've written in five minutes?")
To promote yourself as a writing teacher, you teach workshops--at first unpaid, later paid if you're successful--and appear on conventions panels in the writing track. You answer endless questions, and offer your experience, both for pay and gratis. If you want to move into more of a teaching role, if your fiction isn't that successful or you just love teaching, you do more of this, and you also get the necessary advanced degrees to apply to teach creative writing in a college or university. (Universities simply will not accept publishing credits as sufficient qualification for being on the faculty. If they have a cheapie night-school component, you might get to teach there, but it won't pay nearly as well. A friend of mine teaches creative writing in the evenings at a major university, but she's never been asked to even speak to the "real" English department creative writing classes.) I don't have an MFA or a PhD, and I wasn't even an English major, which totally freaks out English professors. (I had one ask me, at a university gig, "What made you think you could write, if you weren't an English major?" It is to scream silently.)
[aside: there's a squirrel on my windowsill, flirting her tail....so cute. Bushy-tailed rat, but still...so cute. I moved the curtain to see better and now she's on a sapling...nope, just jumped to the ground and bounded off somewhere.]
December 21st, 2009, 04:45 PM #2what the "hidden truth" is
I know you have to say all that to everyone else, your publisher probably makes you,
We had a squirrel once that perched on a window sill, right up against the glass, eating a nut, while our dog was lying nearby and then our cat spotted it and got right up next to it. But it kept eating the nut because it knew that glass was a barrier. Everybody was highly entertained and then when it finished, it flounced off.
December 21st, 2009, 06:48 PM #3
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I was very green at that particular convention, and was simply flabbergasted. How could anyone think that after all that (90 minutes as I recall), there really was a sekrit handshake and even if there was, that such an approach would get it??
As for making up secret keys and magic buttons...no, I'm not tempted. Too lazy, I guess, to do the kind of job it would have to be to fool anyone.
December 23rd, 2009, 03:51 PM #4
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Thanks, Ms. Moon.
Not to ask you to put words in other people's mouths, but given that not every author does try to teach (and that some are simply lousy teachers), do you think that those who do teach (and teach at least reasonably well) enjoy more sales than those who do not?
As you said elsewhere, at the very least you gain some name recognition from teaching. Popular media would have us believe that popularity itself begets popularity, and that exposure and name recognition are hugely important for sales. Whether that flows from word of mouth or the media, it seems to me that increasing your name recognition must have at least some effect on sales (after all, name recognition is really the goal of the entire election process, award process, the basis of celebrity, etc). Hence the question -- do you find that those who teach enjoy greater sales of their own work than those who do not?
It seems to me that being an involved, active voice in the literary community must increase the sense of one's credibility and skill as an author. I certainly don't imagine that respectability is altogether essential to be a successful author, but credibility strikes me as incredibly important -- especially in light of the notion of "literary" works of fiction.
So as a secondary follow-on question -- in your experience, does being an involved, active voice in the literary community seem to have any effect on one's status as a "literary" author? And, have you noticed if there's any appreciable difference in this regard between "mainstream" and genre authors?
December 23rd, 2009, 04:10 PM #5
I'll let Ms. Moon answer for herself, but I will add my two cents if no one minds.
Short answer to Fung's first question: no.
It's a matter of scope. Appearing on a panel, teaching a class, doing a public appearance -- these types of events have a small effect on a modern writer's sales figures. That's why publishers, even the big ones, have shied away from the fabled book tours of the old days; they just didn't make much of a difference on the whole.
I mentioned on another post that I have been considering a second career as a teacher. This isn't to increase my sales (especially because I'm not enough of a jerk to require the students to buy my novel), but because I feel I have things of value to share with developing writers. IMO, this is the only reason to consider an instructional position.
December 23rd, 2009, 04:35 PM #6
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You do keep trying to get me to say what you want to hear, Fung Koo. But sorry, it's the same answer I gave you before.
No, writers who teach do not get more sales *unless* they are selling their books on writing.
Name recognition does not equal sales. Do you buy the books of every name you recognize? I sure don't. Some names I recognize and think "Eeeuw! Not buying that person's book!" I know what popular media says...but popular media is selling itself. Popular media wants everyone to think that a) what is in it is Important and b) what is in it is True, so that people will buy it--buy the magazines, the newspapers, watch the TV shows, etc. What works is writing books people want to read...and then getting enough people to read that first book so they tell their friends about this new writer they found...and those people tell others, etc. Word of mouth.
People who come to workshops are far more interested in themselves than in their instructors (there are always exceptions...but not many), and are there to learn how to get published, the name recognition you get from teaching a class or speaking on a writing panel at a convention is minimal. You get far more from being a bestselling writer in whatever you write....but your numbers have to be really high, or you have to have a lot of books out that are slightly less bestselling than that.
Consider. Everybody knows who J.K. Rowling is. Not because she taught workshops (which as far as I know she didn't) or went to a lot of conventions (which as far as I know she didn't) but because her books took off and sold bazillions of copies. And as is usually the case, many more people recognize "Harry Potter" than "J.K. Rowling" (though if you tell them "She wrote Harry Potter" they will then start bouncing.) If you write a book that takes off like Harry Potter, then you've done all the self-promotion you need to do for the rest of your life. Incidentally, Harry Potter fans are unlikely to buy another book by J.K. Rowling unless it says "By the bestselling author of Harry Potter" on it, because an astonishing number of people don't pay any attention to the writer's name.
Literary fiction is a whole other ballgame from genre fiction, especially this genre (and romance and westerns are in the same boat with us.) The "gatekeepers" for both name recognition and respect are completely different. You can get clout by writing reviews for the right publications, by teaching at the right schools, etc. If you're recognized as an Important Person in the literary world (you have the degrees, you taught at the right place, you wrote suitable essays in the write magazines, and now you have written a novel that touches all the points by which literary novels are judged) you will be respected as a novelist. That gets you nowhere in commercial fiction. Trying to straddle the line can get you kicked hard from both sides: the proponents of literary fiction are often scornful of good sales numbers (if it's popular, it must be bad) and the proponents of commercial fiction are scornful of literary pretensions.
December 23rd, 2009, 05:03 PM #7
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Don't mind at all! Glad for multiple perspectives.
That's why publishers, even the big ones, have shied away from the fabled book tours of the old days; they just didn't make much of a difference on the whole.
Why do you think this is? Any pet theories?
I mentioned on another post that I have been considering a second career as a teacher. This isn't to increase my sales (especially because I'm not enough of a jerk to require the students to buy my novel), but because I feel I have things of value to share with developing writers. IMO, this is the only reason to consider an instructional position.
If your primary goal in teaching isn't to teach, students pick up on it very, very quickly. Correspondingly, they lose respect for you. As it's said, to be truly cool is not to care if you're cool.
But, if writing is your primary profession and teaching secondary, some (like me, for example, who's asking these questions) wonder if that doesn't play into the drive to teach, how one teaches, how one is received by their students, etc.
Apparently, it's not nearly as significant as I had thought.


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This paper proposes an approach for strategic revenue management under uncertainty for real estate projects. It integrates three modelling techniques: first, artificial neural network integrated support vector machines for forecasting the profit and loss-making real estate residential projects; second, analytical network process approach using decision making trials and evaluation laboratory methodology for establishing interrelationships among factors; and third, multiobjective genetic algorithm approach for obtaining optimal numbers and types of apartments in a real estate project. We compare the respective revenues generated with the new number of apartments and price from the suggested revenue maximization model and that of the old practiced one through a case study of India. Copyright © 2015 John Wiley & Sons, Ltd.
A land use many-objective optimization problem for a 1500-ha farm with 315 paddocks was formulated with 14 objectives (maximizing sawlog production, pulpwood production, milksolids, beef, sheep meat, wool, carbon sequestration, water production, income and Earnings Before Interest and Tax; and minimizing costs, nitrate leaching, phosphorus loss and sedimentation). This was solved using a modified Reference-point-based Non-dominated Sorting Genetic Algorithm II augmented by simulated epigenetic operations. The search space had complex variable interactions and was based on economic data and several interoperating simulation models. The solution was an approximation of a Hyperspace Pareto Frontier (HPF), where each non-dominated trade-off point represented a set of land-use management actions taken within a 10-year period and their related management options, spanning a planning period of 50 years. A trade-off analysis was achieved using Hyper-Radial Visualization (HRV) by collapsing the HPF into a 2-D visualization capability through an interactive virtual reality (VR)-based method, thereby facilitating intuitive selection of a sound compromise solution dictated by the decision makers' preferences under uncertainty conditions. Four scenarios of the HRV were considered emphasizing economic, sedimentation and nitrate leaching aspects—giving rise to a triple bottomline (i.e. the economic, environmental and social complex, where the social aspect is represented by the preferences of the various stakeholders). Highlights of the proposed approach are the development of an innovative epigenetics-based multi-objective optimizer, uncertainty incorporation in the search space data and decision making on a multi-dimensional space through a VR-simulation-based visual steering process controlled at its core by a multi-criterion decision making-based process. This approach has widespread applicability to many other 'wicked' societal problem-solving tasks. Copyright © 2014 John Wiley & Sons, Ltd.
During the past decade, Web services (WS) have gained attention, as they provided the means for interoperability between loosely coupled distributed systems over the Web. Regardless of the platforms and technologies deployed in their development, by using WS, the aforementioned systems can seamlessly exchange messages and, thus, engage into business transactions over the global network. Nevertheless, these opportunities resulted in a wide plethora of available WS, making it hard for end-users and composition engines to select the optimal service between two or more services with seemingly identical operational features. As a result, the WS composition engines often make decisions on the basis of the QoS criteria. In modern literature, many researchers have tried to confront the issue of QoS-based composition, by applying multi-criteria decision analysis (MCDA) methods often showing mixed results. This is due to the different characteristics of each MCDA method. In this work, we tried to identify the key criteria that should be taken into account when deciding the optimal MCDA method to use in a given scenario, on the basis of its unique business context, and in addition, we provide an empirical study in order to compare the advantages and disadvantages of the mostly used MCDA methods in the field of WS selection and composition. Copyright © 2014 John Wiley & Sons, Ltd.
There are several generating units available to meet the load demand on any given day. The mixed-integer programme case engages generating units that can be shut down or operated between minimum and maximum output levels within a specific time demand block. An examination of these conditions espouses the utilization of renewable energy technology as a reliable power generation source and its effectiveness and augmentation in a robust, heavily subjugated thermal generation system. The mixed-integer problem has the predisposition to generate many subproblems during the computation. However, with careful selection of the parameters in the model, the challenges are easily overcome. Hydroelectric energy is significant from an operational standpoint as it requires little or no ramp-up time, commonly found in many combustion technologies. The essential load-following capability, peaking capacity and voltage stability attributes render hydroelectric energy as a significant part in ensuring reliable electricity service and in meeting customer needs in a market-driven industry. When this renewable resource is combined with the thermal generation, an improved reliability function is apparent. Yet, in order to minimize the environmental effects inherent in this type of energy resource, the renewable power supply is expected to produce an effectual, consistent output. The integration of renewable generation within the electrical system entails intricate analysis of the transmission line upgrades throughout the system. These upgrades are designed to relieve congestion, improve reliability and provide voltage support by thoroughly evaluating the alternatives to accommodate the new expansion efforts. This paper examines the system integration of renewable generators, via simulated studies, in the context of electrical operations from the hydroelectric generation perspective. Copyright © 2014 John Wiley & Sons, Ltd.
The aim of this paper is to highlight the role of the Decision Support System within the field of multi-criteria decision aid (MCDA). The MCDA tools have been incorporated into systems to create Multi-Criteria Decision Support Systems (MCDSSs). In our literature review, we noticed that more than 100 papers have been written over a 20-year period in which MCDSS was used as a decision-making tool. The present paper describes some real applications of MCDSS in different fields, harmoniously combined with decision-making methods such as analytic hierarchy process, Utility Additive, and Goal Programming. The present study proposes an integrative MCDSS evaluation through guidance on the tools most useful for a specific user with a particular decision problem. Copyright © 2014 John Wiley & Sons, Ltd.
In this paper, we present a decision-aid method with interacting criteria. The fuzzy measures used to aggregate the criteria depend on the considered alternatives. Pairwise comparisons on the importance of criteria and some levels of veto (or favor) degrees, specified by the decision maker, are taken into consideration. For each alternative, we search for the fuzzy measure that makes it the best. The orness degrees of the resulting fuzzy measures are compared and the alternative associated with the minimum orness degree is selected. Copyright © 2014 John Wiley & Sons, Ltd.
The development of forest management plans is a multi-criteria problem that usually involves multiple stakeholders. In forested recreational areas or natural parks, stakeholders could include government officials, forest companies and visitors to the area. With the progress of mobile phone technology, preference information (including aesthetic values) can be conveniently obtained from stakeholders while they are in the forest. This paper develops a methodological approach that incorporates place-specific opinion preference into the development of alternative forest management plans. Through the use of a modified Compromise Programming approach, prospective alternatives are developed, which optimize the opinions of stakeholders and the quantity of timber over time depending on specified parameters. The analysis is based on a small simulated forest holding and place-specific simulated opinion data. To allow for a comparison between potential stakeholder groups, the opinion data was generated by a method that produced three separate groups. The results indicate the practical use of place-specific preferences and provide a means to incorporate the information to generate possible alternative plans. In addition, the analysis highlights that by segregating the preference information into groups, the planning of more specific courses of actions can be made. Copyright © 2014 John Wiley & Sons, Ltd.
Decision makers pursuing several distinct goals may differ in their behaviour. Some try to achieve all goals simultaneously, whereas others concentrate on only certain ones and are therefore specialized. We present a new method of measuring the specialization degree with respect to a given standard balanced relation of the goals. The measurement is integrated into data envelopment analysis (DEA) methodology, uses a non-compensative distance measure, permits optional convex polyhedral cones as predefined balance sets and guarantees feasible solutions. Geometrically, it is based on the angle between the balance cone and the ray through the point of investigation. The proposed models can be used to support and complement the usual effectiveness and efficiency analysis in multi-criteria decision analysis and DEA. They are motivated and illustrated by a simple numerical example, compared with an alternative method recently published and applied to real data from the literature. Copyright © 2014 John Wiley & Sons, Ltd.
In the research area of multiple criteria decision making, very few publications exist that explicitly design the simulation of a decision maker (DM) in an interactive approach. For this reason, we outline some methods widely used in the literature to identify common assumptions of simulating the DM's responses and the required input preference information. Our paper aims at covering the identified gap by introducing experimental concepts. Such concepts are used for theoretical analyses of a combined search-and-decision-making procedure. Simulating the DM is a fruitful idea because the algorithm can be tested without integrating a human decision maker. Finally, we conduct experiments based on the proposed settings for a multiobjective inventory routing problem, which is a relevant and challenging logistic problem. Copyright © 2014 John Wiley & Sons, Ltd.
Measuring computer network efficiency is of great importance for a network manager. When a detailed picture of the current state of the network is available, we can use analytical and simulated-based methods. Instead, it is more difficult to measure network efficiency, when the details of network topologies and internal characteristics are not available. In this paper, we present operations research techniques, which have been used in measuring the efficiency of economic systems, namely data envelopment analysis (DEA), stochastic frontier analysis (SFA) and preference ranking organization method for enrichment evaluations (PROMETHEE). We investigate whether these techniques can be used to assess network efficiency and provide the network manager with a complete set of quantitative suggestions towards relative efficiency improvement of the networks determined as inefficient. The average efficiencies extracted in our benchmark from DEA and SFA are almost equal. Furthermore, the decision maker can adjust the weights of the criteria in PROMETHEE in order to build different scenarios. Consequently, we claim that these methods can be used for measuring computer network efficiency, when networks' internal characteristics are not available. Copyright © 2014 John Wiley & Sons, Ltd.
We investigate methods developed in multiple criteria decision-making that use ordinal information to estimate numerical values. Such methods can be used to estimate attribute weights, attribute values, or event probabilities given ranks or partial ranks. We first review related studies and then develop a generalized rank-sum (GRS) approach in which we provide a derivation of the rank-sum approach that had been previously proposed. The GRS approach allows for incorporating the concept of degree of importance (or, difference in likelihood with respect to probabilities and difference in value for attribute values), information that most other rank-based formulas do not utilize. We then present simulation results comparing the GRS method with other rank-based formulas such as the rank order centroid method and comparing the GRS methods using as many as three levels of importance (i.e., GRS-3) with Simos' procedure (which can also incorporate degree of importance). To our surprise, our results show that the incorporation of additional information (i.e., the degree of the importance), both GRS-3 and Simos' procedure, did not result in better performance than rank order centroid or GRS. Further research is needed to investigate the modelling of such extra information. We also explore the scenario when a decision-maker has indifference judgments and cannot provide a complete rank order. Copyright © 2014 John Wiley & Sons, Ltd.
Multicriteria decision-making (MCDM) methods are concerned with the ranking of alternatives based on expert judgements made using a number of criteria. In the MCDM field, the distance-based approach is one popular method for obtaining a final ranking. The technique for order preference by similarity to the ideal solution (TOPSIS) is a commonly used example of this kind of MCDM method. The TOPSIS ranks the alternatives with respect to their geometric distance from the positive and negative ideal solutions. Unfortunately, two reference points are often insufficient, especially for nonlinear problems. As a consequence of this situation, the final result ranking is prone to errors, including the rank reversals phenomenon.
This study proposes a new distance-based MCDM method: the characteristic objects method. In this approach, the preferences of each alternative are obtained on the basis of the distance from the nearest characteristic objects and their values. For this purpose, we have determined the domain and Fuzzy number set for all the considered criteria. The characteristic objects are obtained as the combination of the crisp values of all the Fuzzy numbers. The preference values of all the characteristic object are determined on the basis of the tournament method and the principle of indifference. Finally, the Fuzzy model is constructed and is used to calculate preference values of the alternatives, making it a multicriteria model that is free of rank reversal. The numerical example is used to illustrate the efficiency of the proposed method with respect to results from the TOPSIS method. The characteristic objects method results are more realistic than the TOPSIS results. Copyright © 2014 John Wiley & Sons, Ltd.
In analytic hierarchy process (AHP), a ratio scale (π1, π2, ⋯, πt) for the priorities of the alternatives {T1, T2, ⋯, Tt} is used for a decision problem in which πi/πj is used to quantify the ratio of the priority of Ti to that of Tj. In a group decision-making setup, the subjective estimates of πi/πj are obtained as entries of a pairwise comparison matrix for each member of the group. On the basis of these pairwise comparison matrices, one of the topics of interest in some situation is the total rank ordering of the priorities of the alternatives. In this article, a statistical method is proposed for testing a specific total rank ordering of the priorities of the alternatives. The method developed is then illustrated using numerical examples. Copyright © 2014 John Wiley & Sons, Ltd.
The governments are under tremendous pressure to sustain high manufacturing growth in emerging economies. Unfortunately, the manufacturing sector consumes much energy and other resources and emits a large amount of green house gases, which increases environmental problems such as climate change and global warming. One possible solution to this problem is green manufacturing (GM) implementation in industry. However, GM implementation faces many challenges. Various motivating factors named as 'drivers' should be facilitated by the government and industry to make this change possible. This paper investigates the drivers for GM implementation and their ranking based on fuzzy technique for order of preference by similarity to ideal solution method using government, industry and experts perspectives. The study concluded that competitiveness, incentives, organizational resources and technology are top ranked drivers and should be facilitated by the government and industry to help implement GM. The ranking of these drivers is expected to help the government and industry to focus on few important drivers to facilitate the GM implementation with limited resources. Copyright © 2014 John Wiley & Sons, Ltd.
This study proposes an integrated qualitative and quantitative assessment of expert opinions aiming at ranking a set of five shantytowns (favelas) located in the city of Rio de Janeiro. These communities are candidates for investments in an energy efficiency program implemented by the local electric utility company. The city, state, and federal governments want to eliminate domination of these areas by organized criminal gangs and present the city as a peaceful metropolis while hosting two big sports events: the soccer World Cup in 2014 and the Olympic Games in 2016. In recent years, some favelas were chosen to be prototypes for an ambitious project to reshape Rio de Janeiro. This involves first sending in special tactics police to drive drug gangs out, then installing the Pacifying Police Unit in the favela. Once security has been established, it is possible to improve general living conditions in these areas, including by providing public services such as health clinics, formal electricity connections and cable television. The core of the energy efficiency program was to convert informal customers to formal ones, because such communities were responsible for approximately 40% of the commercial losses (stolen energy) in the city. The model specification presented in this paper was set up with ten relevant criteria for decision making, identified through an in-depth interview with the decision maker. The relative importance of the criteria and the performance of each favela regarding each criterion were measured by the Simos method. The preferences resulting from this method were translated into a nine-point scale. The imprecision of subjective judgment was partially compensated by using a fuzzy analytical hierarchy process. Some criteria were ordinal, such as 'Fair Relationship with the Community' and 'Complexity to Rebuild the Distribution Lines', whereas other were cardinal, like 'Percentage of Clients in Default' and 'Commercial Loss Due to Energy Theft'. At the end, the model was efficient in ranking the five favelas, therefore contributing to a rational and transparent approach for capital investment in social projects. Copyright © 2014 John Wiley & Sons, Ltd.
With the growing popularity of self-service technologies (SST), businesses have to determine how to combine traditional human service with SST technologies. These mix problems have not received adequate attention in the research literature. This paper offers a decision model for solving mix problems between human service channels and SSTs. The decision problem cannot be determined as a traditional max or min problem and it is fuzzy. In fuzzy problems, the decision maker (DM) is considered as the focal point with the relevant knowledge and preferences and therefore, the objective is to maximize the DM's preferences. This paper develops a decision support system for eliciting a DM's value function when the service channels are considered to be substitutes, but when the rate of substitution may change and then uses a linear-fractional model to fit the DM's data and optimize the DM's preferences. A service mix problem for a grocery store with human service providers and SSTs is used to demonstrate how the decision model can be employed to analyze and solve service mix decision making problems. Copyright © 2014 John Wiley & Sons, Ltd.
Combining established modelling techniques from multiple-criteria decision aiding with recent algorithmic advances in the emerging field of preference learning, we propose a new method that can be seen as an adaptive version of TOPSIS, the technique for order preference by similarity to ideal solution decision model (or at least a simplified variant of this model). On the basis of exemplary preference information in the form of pairwise comparisons between alternatives, our method seeks to induce an 'ideal solution' that, in conjunction with a weight factor for each criterion, represents the preferences of the decision maker. To this end, we resort to probabilistic models of discrete choice and make use of maximum likelihood inference. First experimental results on suitable preference data suggest that our approach is not only intuitively appealing and interesting from an interpretation point of view but also competitive to state-of-the-art preference learning methods in terms of prediction accuracy. Copyright © 2014 John Wiley & Sons, Ltd.
Long-haul carriers are facing a shortage of drivers in North American countries. To reduce turnover rates and improve driver retention, trucking companies are making more efforts to improve their drivers' quality of life. The aim of this paper is to introduce and solve a multi-objective vehicle routing and truck driver scheduling problem under the legislative requirements on work and rest hours in the US (US MOVRTDSP). We present a tabu search algorithm that solves the US MOVRTDSP and provides a heuristic non-dominated solution set from which tradeoffs between operating costs and driver inconvenience are evaluated. The tradeoffs between the number of vehicles used and operating costs are also estimated. Overall, interpretations of the computational results on artificial and real-life instances provide meaningful information to long-haul carriers. Copyright © 2014 John Wiley & Sons, Ltd.
The goal of the crew pairing problem is to partition a flight schedule into sequences of flights called pairings that crew members can operate at minimum cost. It is solved for each crew rank, for example, captains and first officers. In optimised crew pairings, crew often split and join other crew to operate outgoing flights. Because minimum cost pairings contain little buffer time, crew splitting after a delayed flight contributes to the propagation of delay. This effect can be avoided by unit crewing, that is, by keeping crew of different ranks together for as long as possible during a pairing. However, increasing unit crewing increases cost.
We investigate sequential and parallel methods for unit crewing, explicitly considering the two objectives of minimising cost and maximising unit crewing. We apply multi-objective techniques in the sequential approach, where the (minimum cost) pairing problem for one crew rank is solved first and both objectives feature when solving for the second crew rank. Because the quality of the pairings obtained by this method is limited by the solution for the first crew rank, we then propose to solve the two crew pairing problems simultaneously, again using multi-objective optimisation methods. We introduce a multi-objective optimisation model for this problem and propose a new heuristic branching technique that favours unit crewed pairings when applied to a scalarised model with an auxiliary objective function. We compare this with a direct approach with management of the number of unit crewing constraints and a Dantzig–Wolfe decomposition approach.
Numerical tests on domestic New Zealand data show that the multi-objective approaches considerably increase the level of unit crewing, without much increase in cost, even in the sequential approach. Moreover, we show that the parallel approach is superior in terms of quality of the pairing solution but computationally more expensive. The heuristic branching technique provides good quality solutions in reasonable time, as compared with the Dantzig–Wolfe method. Copyright © 2014 John Wiley & Sons, Ltd.
The Dial-a-Ride Problem is a complex combinatorial optimization problem with many real-world applications in transportation of persons. It consists in routing a fleet of vehicles based at a common depot in order to satisfy users' transportation requests. Each request may consist, in a number of persons, a specified pickup location, a destination location, desired departure and arrival time windows. In this paper, we investigate a new and general model for the transportation of persons. It involves three objective functions that have to be optimized in order to measure the potential efficiency of the Dial-a-Ride Problem solution on different aspects: the cost for the transportation operator, the quality of service for users and the impact on the environment. For an efficient search through the solution space, we use a multiobjective genetic algorithm, which allows us to identify a good approximation of the set of Pareto optimal solutions. Among this set of solutions, the decision-maker can select the solution with best compromise according to its preferences, without introducing a priori information about these ones. The proposed genetic algorithm is based on an optimal timing algorithm that computes pickup and delivery dates when the requests are sequenced on the vehicles. Copyright © 2014 John Wiley & Sons, Ltd.
The fast increase in waste materials disposed of by home-health and medical care services as well as by self-attending patients leads to a major concern over the safe disposal of health care waste. In this paper, we consider the design of a collection system for infectious medical waste. These waste materials are produced by patients in self-treatment, stored at pharmacies and picked up by local authorities for disposal.
The stochastic waste collection problem is formulated considering two conflicting objective functions. Social objectives, specifically the satisfaction of pharmacists and local authorities involved in the collection process, as well as the minimization of public health risks need to be traded off against distribution costs comprising routing costs and fixed costs incurred each time a tour is planned. We propose three heuristic solution approaches to solve the real-world motivated inventory routing problem. The suggested methods are tested on real-world data from the region of Provence-Alpes-Côte d'Azur, in France, and their performance is evaluated with several quality indicators. Copyright © 2014 John Wiley & Sons, Ltd.
The traffic police routine patrol vehicle mission is to provide service to the public, primarily through enforcement of traffic laws and assistance to road users after accidents or other calls for service. An efficient traffic police location and schedule assignment (TPLSAP) across a road network ensures that the traffic police undertake their mission effectively. In the search for effective road network cover solutions, a multiple-objective linear program is developed in the first stage with three distinct objectives. The objective functions maximize the following: (1) traffic police presence and conspicuousness; (2) police presence at blackspots where frequent traffic offences occur; and (3) the time available for proactive work. In the second stage of the TPLSAP formulation, distance and time halo effect integer linear programs produce a detailed, daily shift schedule across the planning horizon. Consequently, we formulate a routine traffic police schedule–location and activity problem, which incorporates road safety recommendations drawn from the literature, police policy and operational constraints. Finally, we apply the formulation to a case study of the interurban road network in Northern Israel, which highlights potential improvements over the current schedules. Copyright © 2014 John Wiley & Sons, Ltd.
In this paper, a methodology for the systematic parametric representation for approximating the Pareto set of multi-objective optimization problems has been proposed. It leads to a parametrization of the solutions of a multi-objective optimization problem in the design as well as in the objective space, which facilitates the task of a decision maker in a significant manner. This methodology exploits the properties of Fourier series basis functions to approximate the general form of (piecewise) continuous Pareto sets. The structure of the problem helps in attacking the problem in two parts, linear and nonlinear least square error minimization. The methodology is tested on the bi-objective and tri-objective problems, for which the Pareto set is a curve or surface, respectively. For assessing the quality of such continuous parametric approximations, a new measure has also been suggested in this work. The proposed measure is based on the residuals of Karush–Kuhn–Tucker conditions and quantifies the quality of the approximation as a whole, as it is defined as integrals over the domain of the parameter(s). Copyright © 2014 John Wiley & Sons, Ltd.


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BME103:W930 Group10 l2
From OpenWetWare
BME 103 Fall 2012 | Home People Lab Write-Up 1 Lab Write-Up 2 Lab Write-Up 3 Course Logistics For Instructors Photos Wiki Editing Help | |||||||||
OUR TEAMLAB 2 WRITE-UPThermal Cycler EngineeringOur re-design is based upon the Open PCR system originally designed by Josh Perfetto and Tito Jankowski.
Key Features Heat Sink/Fan: These pieces will be enlarged accordingly with the other parts of the device as necessary for the additional samples. The placement may also be shifted for this accommodation with smaller class sizes. Benefit and Function: Since this device is aimed at being educational, an important factor is price. It will be cheaper to use a larger device to accomodate more students.
PCR Protocol
Research and DevelopmentBackground on Disease Markers


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Vouchers must be purchased by 20 February but could sell out before. Vouchers can be redeemed for 3-night stays until 30 June, 2013. A $15 per night surcharge applies for stays from Thursday to Saturday night, payable direct to the property. A $60 surcharge applies to all school holiday bookings, payable direct. To ensure you get the dates that you want, please book as soon as possible. Quote your voucher number at time of booking. Bookings should be made by 30 May, 2013.
Blackout dates: 22-23 February; 27-31 March. Other blackout dates may apply and all vacancies are subject to availability. All taxes are included. Room upgrade and late checkout are subject to availability. Reservations hold a non-cancellation policy and no-shows will result in forfeiting the full value of the voucher. Vouchers must be presented on arrival and used in one visit. This offer is not refundable. No cash value or cash back. Cannot be combined with any other offer or promotion. A credit card number will need to be provided at the time of booking.
Enjoyed Most | Other Comments | ||||||||
The setting, lovely and peaceful. Very good service friendly. |
Just if they put smokers away from non smokers as their smoke and smelly ash tray smell was overpowering when sitting outside my unit. |
Feb 28, 2015 Venise Australia | |||||||
The room |
Very nice |
Feb 27, 2015 Robyn | |||||||
Peaceful. Very close to beach. Great breakfast. Roomy accommodation. Good parking. Tennis court. Large pool. |
Feb 26, 2015 Lu Australia | |||||||
The facilities, grounds, location, wi-fi and included breakfast were all better than expected. |
A microwave in the room would have been appreciated. |
Feb 24, 2015 Sue Australia | |||||||
Lovely accommodation and friendly staff |
Great facilities, lovely walking tracks near by |
Feb 20, 2015 ELVIE Australia |


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Delete NSFW Duchess BrushieBrush Dec 03, 2012 at 04:18PM EST I knew that even as a kid. I felt like my dreams had been crushed. Also, Tim Allen was in it, so I hated it to begin with. +11 Reply
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On the busSubmitted by Kimmie (not verified) on Wed, 04/18/2012 - 3:59pm.
Are you sure you want strangers on board with your child? Who takes the responsibility that one of these parents is not a sex predator? The group homes responsibility ended when the child was on the bus. »
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Black Crowes Star Steps In For Newsted In Supergroup
by WENN | 03 November 2006
LATEST: Former Black Crowes star JOHNNY COLT will stand in for injured bassist Jason Newsted when rock supergroup ROCK STAR SUPERNOVA tours next year (07) Former Metallica star Newsted was forced to step down from touring commitments after tearing his bicep and rotator cuff in a freak accident. Colt will make his public debut with the group, which also features Tommy Lee and GILBY CLARKE, when Rock Star Supernova performs on the JIMMY KIMMEL SHOW on 21 November (06). The group kicks off its US tour with a New Year's Eve (31DEC06) show in Las Vegas.