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DeviceWatcherStatus enumeration
Describes the state of a DeviceWatcher object.
var value = Windows.Devices.Enumeration.DeviceWatcherStatus.created;
- [Version(0x06020000)]
The DeviceWatcherStatus enumeration has these members.
Member | Value | Description |
Created | created | 0 |
This is the initial state of a Watcher object. During this state clients can register event handlers. |
Started | started | 1 |
The watcher transitions to the Started state once Start is called. The watcher is enumerating the initial collection. Note that during this enumeration phase it is possible to receive Updated and Removed notifications but only to items that have already been Added. |
EnumerationCompleted | enumerationCompleted | 2 |
The watcher has completed enumerating the initial collection. Items can still be added, updated or removed from the collection. |
Stopping | stopping | 3 |
The client has called Stop and the watcher is still in the process of stopping. Events may still be raised. |
Stopped | stopped | 4 |
The client has called Stop and the watcher has completed all outstanding events. No further events will be raised. |
Aborted | aborted | 5 |
The watcher has aborted operation. No subsequent events will be raised. |
The following state diagram shows how the DeviceWatcher transitions between the states represented by DeviceWatcherStatus enumeration.
Minimum supported client | Windows 8 |
Minimum supported server | Windows Server 2012 |
Minimum supported phone | Windows Phone 8.1 [Windows Phone Silverlight 8.1 and Windows Runtime apps] |
Namespace |
Metadata |


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Oral Ulcers After Vaginal Sex With Condom What Are The Chances Of HIV
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
mouth ulcer while licking breast & vaginal fluids during masturbation?Dr. Bob your awesome and I thank you for such a help to people....can u answer my query please?1. While getting a handjob a girl was nude and what if she has some vaginal fluids on her hands and her hands touched head of my penis? But yes some body...Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS Foundation
...Hello,1. HIV risk essentially nonexistent2. HIV risk nonexistentThe only reason to even consider HIV testing would be for psychological peace
Read more »
Truth about oral sex and hiv - mixed messages received from a test counselor (TRANSMISSION VIA ORAL SEX, 2010)I have been tested at 3 months, 6 months and a year all negative. I was told that I should test up... Read more »oral sex and mouth ulcersHi dr BobI read your column all the time as I am constantly anxious about hiv and find great... Read more »
How Risky Is It?...the flu. When either person has open sores that get exposed to infected fluids. These could be cold sores, genital herpes, mouth ulcers, syphilis sores, or other cuts or breaks in the skin. When there is exposure to infected blood . When... Read more »Oral Sex: What's the Real Risk for HIV?... Table of Contents Studies on the Risks of Oral Sex Tips for Safer Oral Sex Taking Care of Yourself The chances of HIV being transmitted from an HIV+ person to an HIV-negativeperson Read more »What You Should Know about Oral Sex...risky sexual activities. Finally, several co-factors may increase the risk of HIV transmission through oral sex, including: oral ulcers, bleeding gums, genital sores, and the presence of other STDs. What is known is that HIV has been transmitted... Read more »HIV and Safer Sex... Table of Contents Sexual Harm Reduction Practicing Safer Sex Thinking it Through Sexual Harm Reduction Most people know that serious, even Read more »
Connect With Others
Oral sex and mouth ulcers
Posted by Anonymous, 1 Reply
...However, over the past week weeks I have been experiencing discomfort under my tongue and have discovered that I have a small mouth ulcer on the underside of my tongue and I am now freaking out. Can HIV be passed from oral sex (didn't...
Read more »
Oral Sex causing HIV?
Posted by jinLA, 4 Replies
...really ashamed to say that I am a medical professional when I look back on my recent behavior. I was in China and received oral sex from a massage girl who had what appeared to be a cold with sore throat (also vaginal sex with a condom). This...
Read more »
HIV Thro' Mouth Ulcer ?!?
Posted by Anonymous, 1 Reply
...opened easily. Hence, after having applied some of it on my hands, washed it then I rinsed my mouth and in that process, the HIV virus may have gotten in my blood stream via my mouth. 2. Some tap water splashed against the blood &...
Read more »
Posted by Anonymous, 1 Reply
...of my foot got all red and started to burn. both were burning and burned for like 6 hours. Second symptom, I had was mouth ulcer. two weeks after my last exposure, I had 3 mouth ulcer in 4 days and they all dissapeared within couple of...
Read more »
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Resource Centers
Guides for People With HIV

subset: commoncrawl


text:
Find Rooms
From USD
per nightGold and Platinum iPrefer members receive two welcome drinks in hotel's lounge when booking here or through iPrefer.com.
This hotel is tagged in:
Family, Retreat, Retreat Collection, Spa
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Aspen, Colorado, United StatesAccommodations
The Limelight Hotel offers luxury Aspen accommodations. Each guestroom features flat-screen satellite televisions, kitchenettes, high-speed wireless Internet access, iPod® docking stations, laptop-sized safes, and more.


text:
Goodlettsville Jobs
Looking for jobs in Goodlettsville? Snagajob has great opportunities with the area's leading companies.
And applying for Goodlettsville jobs has never been easier.
Look at the job listings below, click on a job title that interests you and hit the "apply now" button.
Part-time jobs, teen jobs, student jobs and summer jobs are now just a click away. Start your job search now.
Goodlettsville, TN Job Openings
Cities within 20 miles of Goodlettsville, TN
- Nashville, TN (924 jobs)
- Madison, TN (138 jobs)
- Mount Juliet, TN (105 jobs)
- Hendersonville, TN (94 jobs)
- Gallatin, TN (91 jobs)
- Hermitage, TN (71 jobs)
- Springfield, TN (57 jobs)
- White House, TN (29 jobs)
- Ashland City, TN (23 jobs)
- Antioch, TN (15 jobs)


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Albany Museum of Art
With a history spanning over 30 years, the museum presents various exhibitions each year in seven different gallery spaces. Our exhibition program is designed to reflect diverse cultures, periods, aesthetic styles, and movements. Our AMAzing Space Gallery provides interactive learning through hands-on experiences for children of all ages. The Albany Museum of Art houses an impressive permanent collection which includes one of the largest collections of sub-Saharan African art in the Southeast.
Info & Amenities
Hours of Operation
Tuesday: 10:00AM - 5:00PM
Wednesday: 10:00AM - 5:00PM
Thursday: 10:00AM - 5:00PM
Friday: 10:00AM - 5:00PM
Saturday: 10:00AM - 5:00PM
Admission & Fees
Admission 0.00
Facility Amenities
Free Parking, Parking on Site, Public Restrooms, Self-guided Tours
General Information
Group Amenities
Suitable for Ages
All Ages
Overlapping Sensibilities
01/16/2015 - 04/18/2015
Join us for a solo exhibition of paintings by Surface Design Association member Ray Pierotti.
"My technique is mixed medium based. I use natural untreated fabrics such as cotton, linen or papers. On these surfaces I apply, by brush and hand, multiple applications of colorfast solarized dyes, soft pastels, acrylic paints and color pencils. There are often as many as 80 individual applications of these mediums to the untreated natural surface of one work. Over 800 of my unique painti...
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Family Day
03/14/2015 - 03/14/2015
The Albany Museum of Art and Albany Recreation & Parks Department present Family Day on Saturday, March 14 from 10 a.m. - 2 p.m. at the AMA. There will be plenty of spring-themed art activities, along with outdoor games (weather permitting), and Kiwanis Student Art Show on display in the Willson Auditorium. Admission is free! Please note that all children must be accompanied by an adult.
read more -
Symphony @ the Museum
03/21/2015 - 03/21/2015
The Albany Symphony collaborates regularly with many diverse organizations and agencies in the region. Chamber ensembles perform in three concerts at the Albany Museum of Art. This year, encore performances by guzheng artist Su Chang and the Italian Opera will be held, respectively, at the ABAC Presents! Series in Tifton and the Rylander Theater in Americus. The orchestra has participated with the Albany Area Chamber of Commerce in its hosting of the Red Carpet of Georgia tour. The orchestr...
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text:
To try the thousands of add-ons available here, download Mozilla Firefox, a fast, free way to surf the Web!
CloseChoose from thousands of extra features and styles to make Firefox your own.
CloseName | Maik Lindner |
User since | May 8, 2008 |
Number of add-ons developed | 2 themes |
Average rating of developer's add-ons | Not yet rated |
Sorry for "review spamming". I messed it up (but Mozilla doesn't let me "edit").
So what I want to say is: It really seems buggy and ugly at first sight BUT after having a very closer look and changing some initial values this addon is becoming beauty- and useful.
And please ignore feature request I just found the option.
Ok, I go and have some fresh air now ;)
Thank you.
Imho it's buggy and ugly.
Edit: After changing a few initial values this addon is becoming useful...
Feature request: own background color or image
Nice one. It's almost as good as Multiswitch for Google Chrome: http://bit.ly/bYxiZX - more than 2 servers would be great ;)
Thank you.
Unfortunately it kills functionality of "Gmail Favicon Alerts 3" http://userscripts.org/scripts/show/24430
Umm... sorry! Got it: https://addons.mozilla.org/en-US/firefox/addons/versions/14284#version-0.6.2
kick or change:
#sidebar {
border-bottom: 2px solid !important;
-moz-border-start: 2px solid !important;
-moz-border-left-colors: rgba(80,80,80,0.99) rgba(240,240,240,0.99) !important;
-moz-border-right-colors: rgba(80,80,80,0.99) rgba(240,240,240,0.99) !important;
-moz-border-bottom-colors: rgba(0,0,0,0.99) white !important;
divs with id "sidebar" on website get some thin black ugly borders
Tolles Add-On. Vielen Dank!
This review is for a previous version of the add-on (1.0).Nice idea but doesn't work for me.
This review is for a previous version of the add-on (1.5).Thank you, good ext.
+ combine countdown/notify (ratio option in dialogue)
+ allow minutes > 60s and and calculate eg 81s to 1h21s
+ allow days
+ hide context options pause/resume and stop/reset if no clock is running
+ repeating restarts sound and shows the popup every second? That's annoying...
+ offer the option to set own icons
Looks nice but doesn't work for me, i always get the default theme :( even on a clean new FF 3.6
This review is for a previous version of the add-on (0.7.1).This theme is stunning beautiful! I'm loving it! Excellent work! And as daisylinbluez mentioned hiding the titlebar would be a nice extra :) Keep up the good work!
This review is for a previous version of the add-on (0.5.6).Simply the best one! Danke Pardal!
This review is for a previous version of the add-on (1.1.0_b2).Unfortunately it hides the regular "loading icon" on tabs now.
This review is for a previous version of the add-on (0.4.0.5).To create your own collections, you must have a Mozilla Add-ons account.


text:
Kochi's expectations suffered a jolt when Finance Minister T.M. Thomas Isaac presented the State budget in the Assembly last week. The Minister spoke about the Information Technology (IT) development project in Thiruvananthapuram and the IT Corridor from the capital to Kollam. But those who expected something on Smart City were disappointed. In fact, the Kochi project (Smart City) had faced severe criticism from the Left Democratic Front in the run-up to the Assembly elections.
Anyhow, it did turn out to be bad news for property dealers who had been making hay while the sun was shining.
Whether this phase will continue is a question worrying them.
Several among them are said to be preparing to migrate to the emerging IT fields elsewhere.


text:
10.3 miles
Feather Down Farm Days (Malting Farm)
Colchester, Essex, England Show on map
Try increasing your search radius to within 34, 44, 54, 64 miles of St Osyth.
Try widening your geographic area to: Essex, or South East England, or England.
Remove all or some of the search filters: Remove Lake and/or mountain
Click once to select your first day, and again for your departure day.


text:
Unmanned Aerial Vehicles
Embedded Control
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This book presents the basic tools required to obtain the dynamical models for aerial vehicles (in the Newtonian or Lagrangian approach). Several control laws are presented for mini-helicopters, quadrotors, mini-blimps, flapping-wing aerial vehicles, planes, etc. Finally, this book has two chapters devoted to embedded control systems and Kalman filters applied for aerial vehicles control and navigation. This book presents the state of the art in the area of UAVs. The aerodynamical models of different configurations are presented in detail as well as the control strategies which are validated in experimental platforms.
Wiley; February 2013
Read online, or download in secure EPUB or secure PDF format
Title: Unmanned Aerial Vehicles
Author: Rogelio Lozano
Read online, or download in secure EPUB or secure PDF format
Title: Unmanned Aerial Vehicles
Author: Rogelio Lozano
Buy, download and read Unmanned Aerial Vehicles (eBook) by Rogelio Lozano today!


text: Neoadjuvant treatment with docetaxel plus lapatinib, trastuzumab, or both followed by an anthracycline based chemotherapy in HER2-positive breast cancer: results of the randomised phase II EORTC 10054 study. ; ; et al in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO (2014) BACKGROUND: Neoadjuvant trials conducted using a double HER2-blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high pathological ... [more ▼] BACKGROUND: Neoadjuvant trials conducted using a double HER2-blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high pathological complete response (pCR) rates, but at the cost of important toxicity. We hypothesised that this toxicity might be due to a specific interaction between paclitaxel and lapatinib. This trial assesses the toxicity and activity of the combination of docetaxel with lapatinib and trastuzumab. PATIENTS AND METHODS: Patients with stage IIA to IIIC HER2-positive breast cancer received six cycles of chemotherapy (three cycles of docetaxel followed by three cycles of fluorouracil, epirubicin, cyclophosphamide). They were randomised 1:1:1 to receive during the first three cycles either lapatinib (1000 mg orally daily), trastuzumab (4 mg/kg loading dose followed by 2 mg/kg weekly), or trastuzumab+lapatinib at the same dose. The primary endpoint was pCR rate defined as ypT0/is. Secondary endpoints included safety and toxicity. pCR rate defined as ypT0/is ypN0 was assessed as an exploratory analysis. In June 2012, arm A was closed for futility based on the results from other studies. RESULTS: From October 2010 to January 2013, 128 patients were included in 14 centres. The percentage of the 122 evaluable patients with pCR in the breast, and pCR in the breast and nodes, was numerically highest in the lapatinib+trastuzumab group (60% and 56%, respectively), intermediate in the trastuzumab group (52% and 52%), and lowest in the lapatinib group (46% and 36%). Frequency (%) of the most common grade 3-4 toxicities in the lapatinib /trastuzumab/lapatinib+trastuzumab arms were: febrile neutropenia 23/15/10, diarrhea 9/2/18, infection (other) 9/4/8, and hepatic toxicity 0/2/8. CONCLUSIONS: This study demonstrates a numerically modest pCR rate increase with double anti-HER2 blockade plus chemotherapy, but suggests that the use of docetaxel rather than paclitaxel may not reduce toxicity. This study is registered with ClinicalTrials.gov, number NCT00450892. [less ▲] Detailed reference viewed: 10 (0 ULg)A new era of improving progression-free survival with dual blockade in postmenopausal HR, HER2 advanced breast cancer. Jerusalem, Guy ; ; et al in Cancer treatment reviews (2014) Disease progression despite existing endocrine therapies remains a major challenge to the effective management of hormone-receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2 ... [more ▼] Disease progression despite existing endocrine therapies remains a major challenge to the effective management of hormone-receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2-), advanced breast cancer. Recent advances in elucidating the molecular mechanisms of disease progression have identified the existence of adaptive "cross-talk" between the estrogen receptor (ER) and various growth factor receptor and intracellular signaling pathways, allowing breast cancer cells to escape the inhibitory effects of endocrine therapy. These findings provide the clinical rationale for enhancing or extending endocrine sensitivity by combining endocrine therapy with a targeted agent against a compensatory pathway. In BOLERO-2, adding the mTOR inhibitor everolimus to endocrine therapy significantly improved progression-free survival (PFS) in patients with HR+ advanced breast cancer previously treated with nonsteroidal aromatase inhibitor therapy. Notably, PFS benefits were comparable in subgroup analyses of first- and later-line settings. These results contrast with those of the large first-line HORIZON study, wherein adding the mTOR inhibitor temsirolimus to endocrine therapy did not improve PFS. Therefore, it is unclear whether a targeted agent should only be combined with endocrine therapy to restore endocrine sensitivity or whether it may also prevent or delay resistance in hormone-sensitive advanced breast cancer. Numerous additional targeted agents are currently being evaluated in combination with endocrine therapies, including PI3K, cyclin-dependent kinase 4/6, SRC, and histone deacetylase inhibitors. Appropriate patient selection based on prior treatment history will become increasingly important in maximizing the incremental benefit derived from these new agents combined with existing endocrine therapies in HR+ advanced breast cancer. [less ▲] Detailed reference viewed: 16 (1 ULg)Self-hypnosis, yoga or CBT group to face breast cancer: feasibility study and first results in Belgium Bragard, Isabelle ; Etienne, Anne-Marie ; Faymonville, Marie-Elisabeth et al in Psycho-oncology (2014), 23 (suppl 3) Detailed reference viewed: 48 (11 ULg)Use of mTOR inhibitors in the treatment of breast cancer: an evaluation of factors that influence patient outcomes. Jerusalem, Guy ; RORIVE, Andrée ; COLLIGNON, Joëlle in Breast Cancer (2014), 6 Many systemic treatment options are available for advanced breast cancer, including endocrine therapy, chemotherapy, anti-human epidermal growth factor receptor 2 (HER2) therapy, and other targeted agents ... [more ▼] Many systemic treatment options are available for advanced breast cancer, including endocrine therapy, chemotherapy, anti-human epidermal growth factor receptor 2 (HER2) therapy, and other targeted agents. Recently, everolimus, a mammalian target of rapamycin (mTOR) inhibitor, combined with exemestane, an aromatase inhibitor, has been approved in Europe and the USA for patients suffering from estrogen receptor-positive, HER2-negative advanced breast cancer previously treated by a nonsteroidal aromatase inhibitor, based on the results of BOLERO-2 (Breast cancer trials of OraL EveROlimus). This study showed a statistically significant and clinically meaningful improvement in median progression-free survival. Results concerning the impact on overall survival are expected in the near future. This clinically oriented review focuses on the use of mTOR inhibitors in breast cancer. Results reported with first-generation mTOR inhibitors (ridaforolimus, temsirolimus, everolimus) are discussed. The current and potential role of mTOR inhibitors is reported according to breast cancer subtype (estrogen receptor-positive HER2-negative, triple-negative, and HER2-positive ER-positive/negative disease). Everolimus is currently being evaluated in the adjuvant setting in high-risk estrogen receptor-positive, HER2-negative early breast cancer. Continuing mTOR inhibition or alternatively administering other drugs targeting the phosphatidylinositol-3-kinase/protein kinase B-mTOR pathway after progression on treatments including an mTOR inhibitor is under evaluation. Potential biomarkers to select patients showing a more pronounced benefit are reviewed, but we are not currently using these biomarkers in routine practice. Subgroup analysis of BOLERO 2 has shown that the benefit is consistent in all subgroups and that it is impossible to select patients not benefiting from addition of everolimus to exemestane. Side effects and impact on quality of life are other important issues discussed in this review. Second-generation mTOR inhibitors and dual mTOR-phosphatidylinositol-3-kinase inhibitors are currently being evaluated in clinical trials. [less ▲] Detailed reference viewed: 26 (4 ULg)European inter-institutional impact study of MammaPrint. ; ; et al in Breast (Edinburgh, Scotland) (2014), 23(4), 423-8 AIM: To measure the impact of MammaPrint on adjuvant treatment decisions and to analyze the agreement in treatment decisions between hospitals from 4 European countries for the same patient cohort ... [more ▼] AIM: To measure the impact of MammaPrint on adjuvant treatment decisions and to analyze the agreement in treatment decisions between hospitals from 4 European countries for the same patient cohort. METHODS: Breast cancer patients were prospectively enrolled and MammaPrint was assessed. Patients' clinical data without and then with MammaPrint results were sent to the different multidisciplinary teams and treatment advice was provided for each patient. RESULTS: Using MammaPrint, chemotherapy treatment advice for ER+/HER2- breast cancer patients was changed in 37% of patients by the Dutch, 24% by the Belgian, 28% by the Italian and 35% by the Spanish teams. MammaPrint increased the inter-institutional agreement in treatment advice (chemotherapy or no chemotherapy) from 51% to 75%. CONCLUSION: The results of this study indicate that MammaPrint impacts adjuvant chemotherapy recommendation. MammaPrint can decrease inter-institutional and inter-country variability in adjuvant treatment advice for breast cancer patients. [less ▲] Detailed reference viewed: 18 (1 ULg)Le médicament du mois : Everolimus (Afinitor) dans le traitement du cancer du sein métastatique JERUSALEM, Guy ; RORIVE, Andrée ; COLLIGNON, Joëlle in Revue Médicale de Liège (2014), 69(9), 510-517 Detailed reference viewed: 5 (1 ULg)Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. ; ; et al in European heart journal cardiovascular Imaging (2014), 15(10), 1063-93 Detailed reference viewed: 8 (2 ULg)L'âgisme et ses conséquences cliniques en oncogériatrie: état des lieux et pistes d'interventions Schroyen, Sarah ; Adam, Stéphane ; Jerusalem, Guy et al in Revue Médicale de Liège (2014), 69(5-6), 395-401 Detailed reference viewed: 47 (10 ULg)Final Overall Survival: Fulvestrant 500 mg vs 250 mg in the Randomized CONFIRM Trial. ; Jerusalem, Guy ; et al in Journal of the National Cancer Institute (2014), 106(1), 337 BACKGROUND: At the time of the initial analysis of overall survival (OS) for the Comparison of Faslodex in Recurrent or Metastatic Breast Cancer (CONFIRM) randomized, double-blind, phase III trial ... [more ▼] BACKGROUND: At the time of the initial analysis of overall survival (OS) for the Comparison of Faslodex in Recurrent or Metastatic Breast Cancer (CONFIRM) randomized, double-blind, phase III trial, approximately 50% of patients had died. A final analysis of OS was subsequently planned for when 75% of patients had died. METHODS: Patients were randomly assigned 1:1 to fulvestrant 500 mg administered as two 5-mL intramuscular injections on days 0, 14, and 28 and every 28 (+/-3) days thereafter or fulvestrant 250 mg administered as two 5-mL intramuscular injections (one fulvestrant and one placebo [identical in appearance to study drug]) on days 0, 14 (two placebo injections only), and 28 and every 28 (+/-3) days thereafter. OS was analyzed using an unadjusted log-rank test. No adjustments were made for multiplicity. Serious adverse events (SAEs) and best response to subsequent therapy were also reported. All statistical tests were two-sided. RESULTS: In total, 736 women (median age = 61.0 years) were randomly assigned to fulvestrant 500mg (n = 362) or 250mg (n = 374). At the final survival analysis, 554 of 736 (75.3%) patients had died. Median OS was 26.4 months for fulvestrant 500mg and 22.3 months for 250mg (hazard ratio = 0.81; 95% confidence interval = 0.69-0.96; nominal P = .02). There were no clinically important differences in SAE profiles between the treatment groups; no clustering of SAEs could be detected in either treatment group. Type of first subsequent therapy and objective responses to first subsequent therapy were well balanced between the two treatment groups. CONCLUSIONS: In patients with locally advanced or metastatic estrogen receptor-positive breast cancer, fulvestrant 500mg is associated with a 19% reduction in risk of death and a 4.1-month difference in median OS compared with fulvestrant 250mg. Fulvestrant 500mg was well tolerated, and no new safety concerns were identified. [less ▲] Detailed reference viewed: 37 (4 ULg)Phase Ib study of Buparlisib plus Trastuzumab in patients with HER2-positive advanced or metastatic breast cancer that has progressed on Trastuzumab-based therapy. ; ; Jerusalem, Guy et al in Clinical cancer research : an official journal of the American Association for Cancer Research (2014), 20(7), 1935-45 PURPOSE: Phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway activation in patients with HER2-positive (HER2(+)) breast cancer has been implicated in de novo and acquired trastuzumab resistance. The purpose ... [more ▼] PURPOSE: Phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway activation in patients with HER2-positive (HER2(+)) breast cancer has been implicated in de novo and acquired trastuzumab resistance. The purpose of this study was to determine the clinical activity of the PI3K inhibitor buparlisib (BKM120) in patients with HER2(+) advanced/metastatic breast cancer resistant to trastuzumab-based therapy. EXPERIMENTAL DESIGN: In the dose-escalation portion of this phase I/II study, patients with trastuzumab-resistant locally advanced or metastatic HER2(+) breast cancer were treated with daily oral doses of buparlisib and weekly intravenous trastuzumab (2 mg/kg). Dose escalation was guided by a Bayesian logistic regression model with overdose control. RESULTS: Of 18 enrolled patients, 17 received buparlisib. One dose-limiting toxicity of grade 3 general weakness was reported at the 100-mg/day dose level (the single-agent maximum tolerated dose) and this dose level was declared the recommended phase II dose (RP2D) of buparlisib in combination with trastuzumab. Common (>25%) adverse events included rash (39%), hyperglycemia (33%), and diarrhea (28%). The pharmacokinetic profile of buparlisib was not affected by its combination with trastuzumab. At the RP2D, there were two (17%) partial responses, 7 (58%) patients had stable disease (>/=6 weeks), and the disease control rate was 75%. Pharmacodynamic studies showed inhibition of the PI3K/AKT/mTOR and RAS/MEK/ERK pathways. CONCLUSIONS: In this patient population, the combination of buparlisib and trastuzumab was well tolerated, and preliminary signs of clinical activity were observed. The phase II portion of this study will further explore the safety and efficacy of this combination at the RP2D. Clin Cancer Res; 20(7); 1935-45. (c)2014 AACR. [less ▲] Detailed reference viewed: 30 (2 ULg)LE DÉFI DU CONTRÔLE LOCAL DANS LE CANCER PULMONAIRE NON A PETITES CELLULES, LOCALEMENT AVANCE, NON OPERABLE BARTHELEMY, Nicole ; LENNERTS, Evelyne ; MEYNS, Mia et al in Revue Médicale de Liège (2014), 69(Supp 1), 75-80 Le cancer broncho-pulmonaire non à petites cellules (CBNPC) est fréquent. Pour près d'un patient sur cinq, au moment du diagnostic, la maladie est déjà localement avancée et inopérable. A ce stade, le ... [more ▼] Le cancer broncho-pulmonaire non à petites cellules (CBNPC) est fréquent. Pour près d'un patient sur cinq, au moment du diagnostic, la maladie est déjà localement avancée et inopérable. A ce stade, le pronostic de cette affection est mauvais, caractérisé, entre autres, par un taux élevé de réci - dive locale, malgré la chimiothérapie et la radiothérapie. Le but de cette revue est de décrire l'hétérogénéité de ce groupe de patients, de clarifier les modalités de traitement combinant la chimiothérapie et la radiothérapie et de préciser l'intérêt des techniques modernes de radiothérapie pour améliorer le contrôle local [less ▲] Detailed reference viewed: 64 (10 ULg)Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. ; ; et al in The lancet oncology (2014) BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to ... [more ▼] BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited women with HER2-positive, trastuzumab-resistant, advanced breast carcinoma who had previously received taxane therapy. Eligible patients were randomly assigned (1:1) using a central patient screening and randomisation system to daily everolimus (5 mg/day) plus weekly trastuzumab (2 mg/kg) and vinorelbine (25 mg/m2) or to placebo plus trastuzumab plus vinorelbine, in 3-week cycles, stratified by previous lapatinib use. The primary endpoint was progression-free survival (PFS) by local assessment in the intention-to-treat population. We report the final analysis for PFS; overall survival follow-up is still in progress. This trial is registered with ClinicalTrials.gov, number NCT01007942. FINDINGS: Between Oct 26, 2009, and May 23, 2012, 569 patients were randomly assigned to everolimus (n=284) or placebo (n=285). Median follow-up at the time of analysis was 20.2 months (IQR 15.0-27.1). Median PFS was 7.00 months (95% CI 6.74-8.18) with everolimus and 5.78 months (5.49-6.90) with placebo (hazard ratio 0.78 [95% CI 0.65-0.95]; p=0.0067). The most common grade 3-4 adverse events were neutropenia (204 [73%] of 280 patients in the everolimus group vs 175 [62%] of 282 patients in the placebo group), leucopenia (106 [38%] vs 82 [29%]), anaemia (53 [19%] vs 17 [6%]), febrile neutropenia (44 [16%] vs ten [4%]), stomatitis (37 [13%] vs four [1%]), and fatigue (34 [12%] vs 11 [4%]). Serious adverse events were reported in 117 (42%) patients in the everolimus group and 55 (20%) in the placebo group; two on-treatment deaths due to adverse events occurred in each group. INTERPRETATION: The addition of everolimus to trastuzumab plus vinorelbine significantly prolongs PFS in patients with trastuzumab-resistant and taxane-pretreated, HER2-positive, advanced breast cancer. The clinical benefit should be considered in the context of the adverse event profile in this population. FUNDING: Novartis Pharmaceuticals Corporation. [less ▲] Detailed reference viewed: 33 (4 ULg)A phase IIa, nonrandomized study of radium-223 dichloride in advanced breast cancer patients with bone-dominant disease. ; ; et al in Breast cancer research and treatment (2014) Radium-223 dichloride (radium-223) mimics calcium and emits high-energy, short-range alpha-particles resulting in an antitumor effect on bone metastases. This open-label, phase IIa nonrandomized study ... [more ▼] Radium-223 dichloride (radium-223) mimics calcium and emits high-energy, short-range alpha-particles resulting in an antitumor effect on bone metastases. This open-label, phase IIa nonrandomized study investigated safety and short-term efficacy of radium-223 in breast cancer patients with bone-dominant disease. Twenty-three advanced breast cancer patients with progressive bone-dominant disease, and no longer candidates for further endocrine therapy, were to receive radium-223 (50 kBq/kg IV) every 4 weeks for 4 cycles. The coprimary end points were change in urinary N-telopeptide of type 1 (uNTX-1) and serum bone alkaline phosphatase (bALP) after 16 weeks of treatment. Exploratory end points included sequential 18F-fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) to assess metabolic changes in osteoblastic bone metastases. Safety data were collected for all patients. Radium-223 significantly reduced uNTX-1 and bALP from baseline to end of treatment. Median uNTX-1 change was -10.1 nmol bone collagen equivalents/mmol creatinine (-32.8 %; P = 0.0124); median bALP change was -16.7 ng/mL (-42.0 %; P = 0.0045). Twenty of twenty-three patients had FDG PET/CT identifying 155 hypermetabolic osteoblastic bone lesions at baseline: 50 lesions showed metabolic decrease (>/=25 % reduction of maximum standardized uptake value from baseline) after 2 radium-223 injections [32.3 % metabolic response rate (mRR) at week 9], persisting after the treatment period (41.5 % mRR at week 17). Radium-223 was safe and well tolerated. Radium-223 targets areas of increased bone metabolism and shows biological activity in advanced breast cancer patients with bone-dominant disease. [less ▲] Detailed reference viewed: 36 (3 ULg)Le traitement multidisciplinaire du glioblastome BARTHELEMY, Nicole ; GENNIGENS, Christine ; Scholtes, Félix et al in Revue Médicale de Liège (2014), 69 Detailed reference viewed: 98 (46 ULg)Disease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer. ; ; et al in Current medical research and opinion (2014) Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of ... [more ▼] Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of hormonal therapy (HT), and only recommend chemotherapy for patients with extensive visceral involvement or rapidly progressive disease. This study evaluated actual physician-reported treatments for advanced BC in Europe. Methods: We conducted a retrospective chart review of 355 postmenopausal women with HR+, HER2- advanced BC who progressed on >/=1 line of HT (adjuvant or advanced) and completed >/=1 line of chemotherapy (advanced). Treatment choice was evaluated for each line of therapy. Results: Of 355 patients, 111 (31%) received first-line chemotherapy, whereas 218 (61%) and 26 (7%) switched from HT to chemotherapy in second and third line, respectively. More patients receiving first-line HT had bone metastases (73% vs 27% chemotherapy). Patients treated with first-line chemotherapy had more brain (12% vs 3% HT) or extensive liver (13% vs 6% HT) metastases. Subgroup analysis of 188 patients who received first-line HT and had de novo advanced BC or relapsed/recurrent disease more than 1 year after adjuvant therapy found that the majority (89%; n = 167) of these patients switched to chemotherapy in second line. However, among these 167 patients, 27% had no significant changes in metastases between first and second line. Among the 73% of patients who had significant changes in metastases, 20% had no brain metastases or extensive visceral disease. Conclusions: Our study suggests that the guideline-recommended use of multiple HT lines is open to interpretation and that optimal treatment for European postmenopausal women with HR+, HER2- advanced BC who responded to HT may not be achieved. [less ▲] Detailed reference viewed: 33 (6 ULg)Safety analysis of BOLERO-3 : a phase III trial of daily Everolimus vs placebo, both with weekly Trastuzumab and Vinorelbine in Trastuzumab-resistant, advanced breast cancer JERUSALEM, Guy ; ; et al Poster (2013, December 12) Detailed reference viewed: 16 (3 ULg)A miRNA expression based diagnostic tool for breast cancer using random forests Wenric, Stéphane ; Freres, Pierre ; Josse, Claire et al Poster (2013, December 09) We developed a novel diagnostic tool for breast cancer using circulating miRNA expression levels as features of a supervised machine learning problem. We showed very good results on an independent ... [more ▼] We developed a novel diagnostic tool for breast cancer using circulating miRNA expression levels as features of a supervised machine learning problem. We showed very good results on an independent validation cohort. [less ▲] Detailed reference viewed: 17 (5 ULg)The SNAP trial : schedules of nab-Paclitaxel in metastatic breast cancer. International breast cancer study group (ICGSG 42-12) and breast international group (BIG 2-12) ; JERUSALEM, Guy ; Poster (2013, December) Detailed reference viewed: 33 (1 ULg)BOLERO-3 : Everolimus plus Trastuzumab and Vinorelbine in asian patients with HER2-positive metastatic breast cancer ; ; et al Poster (2013, December) Detailed reference viewed: 18 (5 ULg)BOLERO-3 : Quality-of-life maintained in patients with HER-2 positive metastatic breast cancer treated with Everolimus plus Trastuzumab plus Vinorelbine ; ; JERUSALEM, Guy et al Poster (2013, December) Detailed reference viewed: 21 (2 ULg) |


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When it is dry, I go to Karura almost every week. When it rains, the trails are muddy and not as pleasant for hikes or bikes.
It is a great place to bike with the kids.
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welcome to *nishnish.
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Posted by Amitabh Shukla on October 11, 2009 in Personality Development
Politeness helps us to communicate better. In today's modern world, much interaction take place at both personal and professional level. One has to deal with all kinds of people of different temperaments. A person who can get along well with others is successful in life. For this one has to be polite.
What is Politeness?
Maintaining proper etiquette and speaking properly to a person without offending him or her is politeness. One must not be rude or offensive. One must use proper words to convey something. Foul language can put off a person. Also one has to be choosy about words while conveying something. Whatever has to be conveyed has to be conveyed in a subtle manner.
Why be Polite?
Dealing with people is not easy. Business deals, personal interactions, workplace intermingling all require certain conversational skills. One has to get along with the other person. Team work maybe required at times. A manager has to deal with his or her staff. All these communication forms require a person to be polite. Rudeness can make business deals difficult to settle, or even at personal level one may face rough weather if one offends the other person.
World over much business, trade transactions and diplomatic ties are carried out. Such dealings require a person to be polite and courteous to get the work done. If one is polite one can build up friendly ties.
Consequences of Politeness
Politeness indeed pays off in many ways. Others are impressed by the manner you conduct yourself. They reach out to you. You can communicate better. Differences can be settled easily. There are several institutes which train a person in how to be polite.
Posted by Amitabh Shukla on October 8, 2009 in World Economy
The global economy is just recovering from recession. It was a tough year indeed. Many lost their jobs and were virtually thrown on the streets. Those who had mortgaged their houses had lost their homes. They had no money to pay up the loans. Several people had to survive on unemployment benefits in the US which is very meager. World over the scenario was the same.
What has recession meant to all of us?
Recession has, no doubt, taught us all to understand and appreciate hardships that many millions all over the world face otherwise. It was easy for most people prior to the recession. They had the money to buy luxury goods and lead comfortable life. Perhaps they never visualized that they would have to count their pennies.
For many people in the underdeveloped and developing world recession perhaps did not mean a thing as they always lived in abject poverty. It is mostly the developed countries like the US were hit very hard. Of course what happens in the US economy does have its impact on the world economy. Even in India, times were tough. Many were thrown out of their jobs. There was slump in the market as the purchasing power of the people came down.
Victims of recession suffered from depression and some even committed suicide as they were unable to face the financial crisis in their lives.
What has recession taught us?
It is quite obvious that people need now need to be careful with their spending habits. They should not take things for granted. Simplicity should be given preference. Consumerism is definitely unpredictable in case the economy goes awry.
Consumers yet will continue to behave as they are. Once the economy improves and their purchasing power also improves they will start spending again. People tend to forget past experiences and feel that it was only a bad phase.
Can recession occur again?
Undoubtedly this is a phenomenon that world at times experiences. When it strikes we do not know but it does strike. The lucky ones survive it and those who are unlucky bear the brunt.
By beginning of next year it is hoped that the world economy scenario will change. Slowly, recession will be forgotten and those looking out for employment will be able to fetch a good and decent job for themselves. Memories will remain.
Posted by Amitabh Shukla on October 4, 2009 in Free Wordpress Themes
After a long long time I am launching a new theme. This theme is inline with my last theme Minimalist Love but with more advanced looks and features.
The primary features of this theme are:
The theme has Comment Navigation (if your blog has large number of comments) and supports Threaded Comments.
This theme is widget ready and support tags.
Minimum use of images. You could call it a minimalist design.
Very neat and clean readable part.
Page Navigation Support: You have to download and install the latest WP Page Numbers plugin. This is not necessary and the theme would work without the plugin too but I would recommend the use of plugin.
Author Box:
Feel free to get back to me if you have any problem in using this theme.
Posted by Amitabh Shukla on October 3, 2009 in Entrepreneurship
Investment plays an important role in business. The entrepreneur has to invest money in order to generate products and thus gain profits. Investments play a vital role in business. Without investments, there is no business.
A businessman or woman usually borrows money from the bank and invests in order to produce products. There is a gestation period when the investment is made and when profits actually pour in. The businessman is taking heavy risk as a lot of money is at stake. He or she is taking a calculated risk and hopes for the best. Merely hoping for the best does not suffice. The entrepreneur has to have a acumen to do the business and take on risks. He or she should be sure of the investments they make. They must not face losses and end up with a business venture that is a total failure.
What is business acumen?
A businessman or woman should be sharp enough to know what to invest and what not to invest. He or she must also know where to invest and how to invest. The money invested should fetch returns in terms of profits, otherwise the whole effort will go waste. After all a lot of money is being invested. Mostly, they have been borrowed and the businessman or woman has to pay it back with interest. Naturally, unless and until he or she makes profit he or she will find it difficult to pay it back.
Why business acumen is essential?
Any individual cannot think of doing business. Only a person who is able to understand the nuances of the market and is able to take risks can undertake business. One must have knack for business. He or she should be able to understand what business is all about, how to face competitors and also how to get maximum returns from the investments made.
The world of business is full of sharks. Everybody is out to get the other person. There is no place for emotions or taking it easy. A person should be full of confidence to find his or her way in this cut-throat competitive world of business.
Business is well paying if it is a successful venture, unlike job which is provides you with limited income. Risks are greater in business. In case of financial loss, one can get completed wiped out. Yet, many like to take on such risks and carry out business as they enjoy it.
Posted by Amitabh Shukla on October 2, 2009 in Technology
I am sure Alexa is not the most appropriate tool to do this type of analysis. However, their results are fairly accurate when you consider ratings of top 100 websites and that too if they are in the similar domain.
I tried to compare orkut, facebook, twitter and aging myspace.com ratings for last 2 years. Here are the findings:
2008 was turning point for social networking websites. The process for fall of 2 giants (myspace and orkut) and the rise of two (facebook & twitter) started somewhere in the mid of 2008 which is very evident on the Alexa graph above.
Why Myspace.com is dying?
Myspace is only for Teens:
Myspace is not only restricted for teens but they are primarily geared towards teenage audience. The personal pages at myspace are way too loud, colors very bright, background images used are too big, audio and video too heavy and everything which same people (who created them) would not like once they grow. The users of myspace primarily consist of MTV lovers, teens, school kids etc.
Myspace was sleeping while Facebook was gaining ground:
In the web2.0 era, the company which innovates regularly and is most responsive to change wins. In terms of change and innovation myspace was sleeping throughout 2008. Facebook on the other hand was constantly innovating, changing its interface, introducing applications and other innovative features to appeal and reach larger audience. After they (myspace) realized, it was too late and they started replicating the popular facebook features which was again not taken nicely by its teen audience.
Criminal activity at Myspace further tarnished its image:
There was lot of news about myspace for lots of child predator cases. Myspace tried to remove registered sex offenders and took lot of further cleanup actions but its image among parents took a nosedive by then and a big dent was made.
Spam Filters:
Myspace spam filters were very weak and nothing was done to strengthen it up. The way spam messages had free way annoyed lot of its users.
Tastes of people for social media is changing:
I signed up for twitter in 2007 but never used it as I could not find how it could help me in anything. I thought myspace blogs were cool but things have changed in last 2-3 years. Now I like fast messages more, then long-style communication of myspace blogs.
Posted by Amitabh Shukla on October 2, 2009 in Jobs and Career
Parents in the present times have a major role to play in helping their child decide his or her future career. No doubt, the child has to make his or her own decisions, but timely guidance and mature advice helps them to take on a course of action that would brighten up their future prospects.
Why parent's advice is required?
Children are often confused as to what they should do. Of course, peer pressure often makes them decide upon a particular career. Yet they need some mature advice as to what is the right course of action. Most young people these days do not like their parents to interfere in their decision-making, yet they do not mind what they have to say about a given situation.
Parental opinion helps them to sort out their confusion. Of course, they are unable to decide which career to choose. Here parents are able to sort out the confusion in their minds by informing them about the positive and negative aspects of a particular career.
Children are always apprehensive about the future- what their life will be if they choose a particular career goal path. Will they enjoy prosperity? Will they face failure? Parents have to show much concern to their worries and try to explain to them that whatever they choose would be for their own good as the decision is their own.
Do children dislike parental interference in career matters?
Despite children wanting their parents to guide them, yet they would like to take their own decisions. They generally do not like to be told what to do. They do seek advice, but the final decision is theirs. They like to be independent of their parents.
In some countries, particularly in the East, parents do a play role in the decision-making process of their children. But in the West, children despise too much parental interference. Nowadays, even in the East, modern cultural trends are curtailing parental involvement in the affairs of their children.
Children do need the support and mature advice of their parents, but yet they hesitate to allow them decide what career they should pursue. They like to undertake something they feel that suits them best. Parental help maybe required to clear up confusion, but only to that extent. Final decision the child makes.
Posted by Amitabh Shukla on October 1, 2009 in Website Reviews
Orggit provides instant access to your life's most important information.
Orggit is a comprehensive personal document management solution. Divided into four distinct sections (Wallet, Medical, Accounts and Codes, Filing Cabinet), Orggit allows users to have a place to securely store all of their life's most important information, with access to it anytime they have internet connection. Orggit also have an iPhone application that makes accessing this information even easier when the user is not near a computer.
Why this startup is unique?: Orggit is unique because of their comprehensive solution. Many document management products out there right now only allow you to store one aspect (i.e. only medical, passwords, wallet information). Orggit, however, allows you to store ALL your information in one secure place.
Founder: Thania Panopoulos (CEO) is a marketing and sales executive with experience in the financial services, technology and retail industries, holds a BA from Boston College and an MBA from the J.L. Kellogg Graduate School of Management at Northwestern University.
URL: www.orggit.com
Posted by Amitabh Shukla on September 29, 2009 in Getting into Roots
We all want to win. Whether it be a game or at work place we work hard in order to defeat others and thus be winner. The urge to win makes us strive harder than usual. Not all win, but some do, perhaps the will and determination to win makes it easier to reach the set targets and goals.
Reaching the finish line is tough. It requires much effort. The desire and will to attain heights needs to be there. One must feel a winner.
But the question that arises is why win?
The motive behind winning
Being a winner makes one feel good. He or she is on the top of the world. Whatever one undertakes, one would like to excel in it. No one wants to lag behind. To win over others makes one feel triumphant and victorious.
If one loses out then demoralization sets in. In case, one wins then one's confidence levels go up. One feels more energetic to do things. In fact, one feels like taking on more challenges in life as one feels that one can be a winner.
Benefits of being a winner
A competitor would like to win. Whatever challenges he or she takes on one must be complete it successfully.
Posted by Amitabh Shukla on September 29, 2009 in World Economy
The world is not all that perfect. Economic disparities exist among nations. Many countries are poor. People are living in abject poverty. Countries like India and Pakistan are unable to feed their population. Many suffer from malnutrition and disease. Why is this so?
Why does poverty exist?
Poverty is indeed a curse. People suffering from it are unable to meet their basic needs of food, clothing and shelter as well as medical help. They experience hunger and are unable to change their circumstances as they remain in a vicious cycle which is difficult to be undone.
Lopsided economic development within a country and neglect of dealing with economic backwardness has led to poverty. Over population is another cause. Several developing and under developed countries do not pursue economic policies rigorously to eradicate poverty.
How can poverty be tackled?
Why is poverty a curse?
Poverty is a curse as many people are poor and are unable to meet both their ends. They are unable to survive even on bare minimum. Many people remain hungry as they are food needs are not met. Their purchasing power is nil and they cannot purchase food, shelter and clothing.
Malnutrition is very common among the masses and disease spreads quickly. Medical facilities are almost nil or not up to the standard. Most children are deprived of education and are forced to work in appalling conditions. Unemployment results in poverty. Work opportunities are minimal. Daily wager earners do not find work.
Poverty restricts the growth of the individual. He or she who is living in abject poverty cannot contribute to the society in any way. He or she is a burden on society. It is not his fault though. The respective Government has failed to provide adequate facilities for his mental and physical growth.
Much needs to be done by the respective Governments to eradicate poverty. The progress of a country depends upon what comforts are provided by the respective Governments to their people. Poverty can be completely eradicated in case the right economic measures are adopted.
Posted by Amitabh Shukla on September 25, 2009 in Jobs and Career
Some people know what they want to be from as young as 5 years of age. However, most people still do not know what they want to do in life even after a few years of working. Therefore, learning how to choose a career is not only for high school students or those in college. Some professionals decide to change careers simply because they do not like the job they currently have. This mostly happens because you took on a job not because you like it or enjoy it but because you need the money. After about five or ten years, you realize that you hate your job and it is not what you want to do until you retire. In this case, getting career guidance is very important.
First step in choosing a career is by understanding yourself. This will help you realize what you enjoy doing and if you can make money doing it. The best way to do this is taking a personality test. These tests are available on almost all career-oriented websites on the internet for free. It is also important to understand your values and know what you are willing to do and what you consider morally or professionally wrong. If there are certain aspects of your job that you do not like, you are more likely than not in the wrong career. Another way to do this is establishing your hobbies and what you do during your free time. Hobbies such as painting, throwing parties, writing or singing can easily be incorporated into a career by taking design lessons, becoming an event planner, an author or an entertainer respectively.
If you have sources such as a career guidance counselor or a career center, it would be the best place to start. If not, visiting career websites can also make the process easier. If possible, apply for internships or volunteer in a profession that appeals you. You can shadow a professional in that industry and decide if that is the career path for you. This should last about a month or two and you will understand what a day-to-day life would be in that industry.
Another tip in choosing your career is learning universal skills such as writing, typing and computer skills among others. When you study something that leads to just one career, then you have closed all other opportunities for changing your career in the future. Therefore, before embarking on a specific college degree (like medicine or law), ensure that that is what you want to do for the rest of your professional life. Choosing a career is important because most of our lives are spent at work. Therefore, incorporating our interests and hobbies into our careers can result in the best jobs we can hold.


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Whether kicking game winning goals for the Portland Thorns of the National Women's Soccer League, strutting down a fashion runway or penning inspirational children's books, Alex Morgan does it all with a smile on her face. There is never a dull moment for the Olympic gold medalist, and that is the way she likes it.
From a young age, Morgan has always shown the ability to excel. A multi-sport athlete who never let education fall by the wayside, she graduated early from the University of California Berkeley while competing on the U.S. National Soccer Team.
"I thought that I could graduate early and if I could make the World Cup team it would work out perfectly. But it ended up working out better than I imagined," Morgan said.
Her performance in the World Cup won her the 2011 FIFA World Player of the Year and a place in the record books as the first player ever to have both a goal and an assist in a World Cup Final.
Despite her many talents, Morgan always knew that she wanted pursue soccer and set herself a lofty goal.
"When I was 8 years old I knew that I wanted to be an Olympian, and then the '99 World Cup rolls around and we had Kristine Lilly and Mia Hamm and all of the girls winning. At that point I wanted to be them, I wanted to be in their shoes," she said.
Now 23, Morgan is giving back to other young girls who dream of becoming professional athletes with her book "The Kicks: Saving the Team." It is the first in a projected series of three she hopes will inspire young girls to follow their dreams.
"It doesn't matter what your dream is," Morgan said. "They should just feel like they can do anything because the sky is the limit."
Check out more from In the Game at ESPN.
As a shining example for young girls everywhere, Morgan embodies this message of hope.
"They can achieve whatever dreams they have if they set their minds to it and believe in themselves and have the confidence in themselves," she said.
And what is her secret to feeling confident and empowered before a game? Music.
"Fun, pop music. Katy Perry, just upbeat music that you can dance to. Old school rap, whatever it is, anything that gets us on our feet, gets the nerves out and helps us just have fun," she said. "Because at the end of the day that's what it's about for me I think my teammates as well, enjoying the game, having fun and just loving the moment we are in."


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Bedding & Bath
Resort Duvet Cover
Resort sheets
Linen Color is beautiful and true to catalog images. Sheets are nice quality and are 'thicker' than average sheets as advertised. Not necessarily as wrinkle-resistant as advertised.
February 18, 2014
Really Resort Like Sheets
Love these sheets! Even after washing they were smooth and luxurious to slip into. Just like at a resort. I have the king size but have large queen size pillows so the cases were a bit long but I altered them to be shorter and they look great.
February 12, 2014
Resort Duvet Cover
Beautiful embroidery detail and smooth luxurious fabric. I have several of these and always get complements on them.
February 3, 2014
extra pillowcases
These pillowcases are well made and the fabric is soft and of good quality. Wish they didn't come out of the dryer so wrinkled.
January 2, 2014
Resort Bed Sheets
These are PERFECT ! To prevent any wrinkling I on wash them in Dreft detergent, use 2 capfulls of
Downy in rinse and dry on low heat or air dry in dryer.Once on bed I use steam iron to press that
lovely topping and the pillow cases. Love'em--
just PERFECT .The best I have ever purchased!!!
October 4, 2013
Size a bit large
The fitted bottom sheet was 2 inches wider than our King-size mattress, which results in a looser fit than we like.
September 27, 2013
deeply disappointed
The duvet has ties on each corner and a sturdy button closure at one end. However, the fabric easily wrinkles and is very loud. I had it professionally pressed and after the first night it looks like it came out of the dryer. I am deeply disappointed I can't return it , and have wasted money on this product. When I put the cover on my comforter I saw huge strings of the embroidery coming apart from the stitching. The fabric isn't very soft and feels thick. I am going to be very annoyed for 5 years till my husband agrees to buy another set.
July 15, 2013
Fabulour Sheet Set!
I absolutely love the Resort Sheet Set I bought from you. They are so luxurious and really beautiful. They help to make my bedroom a tranquil retreat. Love 'em!
July 9, 2013
Resort Sheet Set
We LOVE these sheets! crisp and clean up great! Saving up for another set!
July 4, 2013
Not so soft
I have purchased sheets from Frontgate before and they were so soft and comfortable. I was disappointed that these resort sheets are not soft.
June 23, 2013
luxurious towels
These towels are the best I have ever owned and I enjoy luxurious towels! The are highly absorbent, drape beautifully and are soooo soft. I ordered the Honeywheat to go with the FG Egyptian cotton blanket in camomille. The colors complement one another very well and the look has spruced up my bedroom like a refreshing summer breeze.. Treat yourself to these towels!
June 18, 2013
Resort Sheets
I'm a long time customer with Frontgate and for the first time ever I had to return a product. I puchased the sheets after reading such "glowing" reviews. The sheets were so rough to the touch that at 2:00 in the morning I stripped the bed. Just the worst night's sleep.
June 10, 2013
Outstanding qulaity and service
The monogramed bed sheets purchased at Frontgate reaffirmed the comitment to deliver qulity products at fair prices. This is also backed up by no hassle service. When we reiced two standard pillow cases and two King pillow cases, the issue was addressed quickly with no extra cost to us, even though the items where mongramed.
May 21, 2013
As usual, excellent service and quality.
We are very picky when it comes to bed linens. These exceded our expectations!
May 2, 2013
Great sheets
I recently purchased a set of sheets. The color was perfect. They are extremely comfortable. They clean-up great and are a pleasure to work with. Compared to a past purchase elsewhere, they make sleeping a real pleasure.
April 28, 2013
Soft, but wrinkly
Overall love the duvet cover and matching sheets, but it is difficult to get wrinkles out, even fresh out of the dryer. Material is very soft and airy. Nice against the skin!!
April 25, 2013
Simply Gorgeous
This embroidered duvet is elegant, simple, and gorgeous. Classic simplicity at its finest!
April 25, 2013
I ordered the Duvet with expectation of it looking like the picture. This was the first duvet i have purchased and didn't realize that I was suppose to put "inserts" to give it that full look like the picture. When I received the duvet it looked like a sheet. Although the embroidery was beautiful, I don't think the cover was true to what you see in the picture. I also hated that it arrived wrinkle and you will need to iron it often to keep the crisp look. I decided to return it because it did not present itself well.
April 19, 2013
Great value
I bought the whole set for my new King Size bed! Looks great and quality is very high. Recommend to buy it.
April 18, 2013
I found the pillow cases to be short. They are just long enough to barely cover the pillows. There is no additional fabric to cover the pillow enough not to show. The cases ride up while in use and the pillow isn't completely covered.
April 16, 2013
Resort Sheet Set
I have purchased hotel quality sheets prior to these but my previous sets never felt like these
The quality of the cotton has a very strong feel to it
My previous sheets always shrank after several washings and pilled , and they were a high thread count
One suggestion , the free monograming is beautiful but they did not produce the script of the letters as they appeared in the catalog. They offered to return them but I felt badly asking them to do that
So my script was to be vCa but they came out VCA all the same size and font is large,,I would write out. Exactly how you want them to look . I checked the correct style just as the catalog showed but I would still write it out as to double check to the embroidery person how they should look
April 1, 2013
March 30, 2013
Resort Sheet Set
These sheets are really great. Best sleep I've had in a long time. They wash well (but wrinkle a bit). This is a luxury that is absolutely worth it.
March 29, 2013
Elegant better than resort sheets
Each year I buy at least 1 set of sheets for my wife because we both enjoy sleeping on comfortable and high quality sheets. Our guests rave about the comfort and quality of these sheets swearing they slept like "royalty". We tried to purchase sheets from other sources other than Frontgate but we always return for the quality of the merchandise and quality buy back guarantee. Stop buying imitations and pretending you're saving money and spend the money for these sheets. You won't regret it.
March 28, 2013
Great sheets!
I ordered two sets but one was subpar. Frontgate accepted the return at their expense and sent me a perfect exchange in record time!
March 23, 2013
Not crazy about these sheets.
I've ordered these sheets in the past, and they've been great. Soft, almost satin like feeling. We recently purchased a larger bed, so I ordered the same sheets in a larger size. I'm disappointed. The quality isn't nearly as good. The sheets are a bit scratchy. Wish they would make them like they used to. I will say my old sheet set was the embroidered pattern, and my new set is the straight hem. Maybe that makes a difference in the quality?
March 19, 2013
less satisfied
For the first time in the years that we have purchasing from you we were not totally satisfied with the sheets. First looks like you have change supplier since these sheets are not of the same quality that the ones we purcharsed a few years back, second the monograming is so tight that it puckers all around. Sorry that I have to give this review but you have always had the best and we have been always 100% satisfied qith our purchases. This is only given has a way for you to know if something is not right.
March 15, 2013
Not what I was expecting
Purchased the Resort sheets and washed before trying them. Felt like I was sleeping on fiberglass! Washed 5 more times before trying again and although they feel better, still not worth the price. Hopefully with a few more washings they soften up. The durability seems good, just not smooth.
February 24, 2013
Great purchase, great product.
This sheet set ("Resort Sheet Set") is everything that you promised it would be. Beautiful, perfect fit and a wonderful "feel". Thank you, Front Gate.
February 14, 2013
sheets not worth the price
I was looking for smooth, good feeling sheets. These are not as smooth as I would like and I'm very disappointed in how wrinkled they look. Definitely not worth the price.
February 12, 2013
(10 Questions : 18 Answers)
Product Q&A
Get help about this item from fellow customers. Ask your questions. Share your answers.
Resort Duvet Cover
1 answer
Box Spring Cover Thickness
Is the white box spring cover thick enough so that the box spring cannot be seen through the fabric?
9 months ago
The box spring will not be visible if you use the box spring cover.9 months ago
Has staff answer
Resort Duvet Cover
1 answer
Are these sheets 100% cotton? Are they Egyptian cotton?
Also Does the box spring cover fit a Tempur-Pedic ergo adjustable base?
1 year, 1 month ago
Thank you for your interest in Frontgate. The Resort Bedding color featured in the main image is the Surf color. The box spring cover is not recommended for use with a Tempur-Pedic Ergo Adjustable Base.Has staff answer
Resort Duvet Cover
1 answer
I'm interested in the resort box spring cover, and would like more product information: fabric content, dimensions, and a picture would be helpful.
1 year, 6 months ago
Thank you for your interest in Frontgate. The Resort Box Spring Cover has the following features. Regrettably, we do not have a photo of this item.• 600 thread count long-staple microcotton
• Brilliant sheen and excellent drape
• 100% cotton sateen
• Queen (60"W x 80"L x 16"D; 0.70 lb.)/King (78"W x 80"L x 16"D; 0.80 lb.)/California King (72"W x 84"L x 16"D; 0.80 lb.)
Resort Duvet Cover
1 answer
Can I order a mix of sheet sizes in this line?
I am ordering the Resort Duvet Cover and want sheets to match. I have a King Ergo Temperpedic bed with split matresses. I need 2 twin fitted sheets and a king or cal king flat in the same color. Can you help?
1 year, 11 months ago
Thank you for your interest in Frontgate. All of the sheets and colors we offer can be found on our website @ Frontgate.com. You can place an order on the website or by phone.1 year, 11 months ago
Product:45687-Resort Bedding Collection


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Wyoming Economic Development Directory
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Wyoming State Incentives
The BUSINESS READY COMMUNITY GRANT & LOAN PROGRAM can provide financing for publicly owned infrastructure that promotes economic development within Wyoming communities. Cities, towns, counties and joint powers boards are the primary applicants for the program. The typical maximum award is $1.5 million with a 10 percent match. Publicly owned infrastructure that facilitates a specific businesses needs.
INDUSTRIAL DEVELOPMENT REVENUE BONDS: Cities and counties may issue tax-exempt industrial development revenue bonds to provide financing for manufacturing and energy generation businesses. These bonds are issued within the State's IRS allocation of tax-exempt bond financing. The maximum project was increased to $600,000,000 in 2011 and the business must provide a bank "letter of credit" to guarantee payment of the bonds. Interested businesses must apply for an allocation within the State's volume cap. The Wyoming Business Council will coordinate this process.
WYOMING PARTNERSHIP CHALLENGE LOAN PROGRAM: The Wyoming Business Council can participate with a local lender on a loan to a business. The State's portion of the participation maybe up to 35 percent of the project (maximum $500,000) in a shared note and collateral position with the local lender. Participation can be increased to 50 percent of the loan or $1,000,000 is the lender has secured a federal guarantee (i.e. SBA, USDA) to guarantee repayment of a loan made to a business.
The MANAGED DATA CENTER COST REDUCTION GRANT PROGRAM (Passed 2009) is a $2.25 million maximum grant that can be used to reimburse accrued utility expenses for power or broadband over 3 years. In exchange for providing these reductions in costs, the applicant (a Wyoming city, county, joint powers board) shall contract with the business to receive direct benefits and indirect economic development benefits including a specific amount of capital investment from business, specific minimum payroll created by the business, the provision of discounted IT services.
DATA CENTER SALES TAX EXEMPTION (originally passed in 2010, amended 2011): Requires a $5 million investment in capital infrastructure (building, walls, engineering, dirt work, etc) in a Wyoming location in addition to a $2 Million or larger investment in data center equipment (servers, peripheral equipment and data center containers) and software purchases. If these thresholds are met the sales tax burden on the qualifying computer equipment is exempt. This exemption can be applied if the data center invests $2M in equipment a calendar year in the future. In 2011, the Wyoming State Legislature added another tier requiring a $50 million capital infrastructure level. This tier also requires the $2 Million in data center equipment purchases. At this tier the qualifying exempt equipment also includes uninterruptable power supplies (UPS), back-up power generation, specialized heating and air conditioning equipment and air quality control equipment.
DATA CENTER PERMIT EXEMPTION (passed 2011): A mega-data center project, which exceeds $178.3 Million in capital investment, would be exempt from the requirement of applying for an Industrial Siting Permit through the Wyoming Department of Environmental Quality. This presents a cost savings of approximately $500,000 associated with permit application preparation, wildlife studies, economic analyses, public meetings, permit hearings, attorney fees, etc.
DATA CENTER INFRASTRUCTURE GRANT FUNDS (passed 2011): A $15,000,000 appropriation to assist Wyoming cities, towns and counties to build necessary public infrastructure for the recruitment and operation of data centers.
FARMERS MARKET PROMOTIONAL GRANT: The Wyoming Business Council offers a $400 reimbursable grant for advertising and promotional materials to Wyoming farmers markets that can be used by a local Wyoming government agency, a Wyoming association, a Wyoming nonprofit organization (e.g. Chamber of Commerce) or a Wyoming Producer Association that conducts a farmers' market.
ORGANIC CERTIFICATION REIMBURSEMENT PROGRAM: Funded by the U.S. Department of Agriculture, in conjunction with the Wyoming Business Council, it is designed to help Wyoming processors with the costs associated in becoming organically certified. Two kinds of Organic Certification Reimbursement Grants are available. Wyoming businesses (organic processors) and Wyoming farms/ranches (organic producers) are eligible to apply.
WORKFORCE TRAINING GRANTS (WDTF): Created by the 1997 Wyoming Legislature and administered by the Wyoming Department of Workforce Services, it assists new and existing industries in the state with the training needs of newly hired or current employees. Grants are available for up to $4,000 per trainee.
COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM: Administered by the Wyoming Business Council, it provides grants to local governments for community and economic development projects and makes convertible loans based on job creation as well as other tools that may assist businesses.
MANUFACTURING SALES TAX EXEMPTION: The sales tax burden is exempt on the sale or lease of machinery to be used in the State of Wyoming directly and predominately in manufacturing tangible personal property.
SALES TAX EXEMPTION ON ELECTRICITY USED IN MANUFACTURING: The sales tax burden is exempt on sales of power or fuel to a person engaged in the business of manufacturing, processing or agriculture when the same is consumed directly in manufacturing process.
Sales are directly tied to marketing Wyoming companies' services and products. The Wyoming Business Council offers help through several programs.
- COOOPERATIVE ADVERTISING: The Business and Industry Division offers economic development groups and businesses the opportunity to join cooperative advertising in national publications.
- COOPERATIVE MARKETING PROGRAM: The Business Council secures booth space at trade and selling events to share, at minimum cost, with WY businesses and local economic development groups.
- MARKETING CONSULTING/MEDIA TRAINING: Consulting and training helps Wyoming businesses fine tune their marketing and public relations efforts to reach their target audience.
- TRADEMARK LICENSING PROGRAM: The Business Council has an agreement with the Secretary of State to use the Bucking Horse and Rider logo.
- TRADE SHOW INCENTIVE GRANT PROGRAM: Encourages state businesses to promote and sell their WY-made products to statewide, national and international audiences with grants to help offset the costs of the trade events. It is a reimbursable grant; and as such, the applicant must pay all expenditures before the grant award can be disbursed. The business shall function independently in performing this activity and shall assume sole responsibility of any debts or liabilities that may be incurred in regard to this trade event.
- WYOMING FIRST PROGRAM: Assists Wyoming companies with the identification and promotion of their Wyoming-made products and services. Participants can use "Bucking Horse and Rider" design stickers and hang tags and have their companies featured in a catalogue and a Web site.
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SMALL BUSINESS NON-PROFIT ENERGY AUDIT PROGRAM: A matching grant that provides 50 provides for a level 2 energy audit up to a maximum of $2,500. A Level 2 Energy Audit will include quantification of energy users and losses through a detailed review and analysis of equipment, systems and operational characteristics. After the energy audit is conducted, the remainder of the grant may be used to pursue energy retrofits identified in the audit. Retrofit and audit funds are up to a maximum total of $5,000 with a 50 percent reimbursement. Manufacturers may use the audit to qualify for a sales tax abatement on the energy used in the manufacturing process.


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10 Magazine Celebrates Tenth Anniversary with Ten Designer Covers
>> It's not often that a designer graces the cover of a magazine, but in celebration of a decade since its launch, 10 magazine wrangled ten "fashion gods" for ten separate covers — each photographed by the lensman of their choice. Helmut Lang sent in a passport photo, Domenico Dolce and Stefano Gabbana commissioned Terry Richardson, Vivienne Westwood had Juergen Teller capture her, Ralph Lauren was snapped by Bruce Weber, and Karl Lagerfeld submitted a self-portrait. Alber Elbaz, Azzedine Alaia, Donatella Versace, John Galliano, and Tom Ford round out the rest of the designers featured.
"These are some of the faces that have made our industry and it is an honour to be celebrating them. 10 magazine has a history of celebrating the best creative talent in the world and we are honoured that these icons of fashion agreed to be our cover stars," said Sophia Neophitou-Apostolou, the magazine's founder and editor-in-chief (who is also creative director and fashion director at Harper's Bazaar UK).
- This Vogue Japan shoot would make Barbie proud — Who What Wear
- Zac Posen has a new job to add to his résumé — The Cut
- These shots prove Anna Wintour's just like us — HuffPost Style
- The ladies of Downton Abbey have stylish offscreen moments too — InStyle
- A roundup of the best denim moments in history — Racked
- How old is too old for those trusty cutoffs? — SheFinds
- Why Carven might be debuting a brand-new look at PFW — Style.com
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sorry it took so long to get back to you guys. ive been trying to find where my heads came from (aside what the guy told me =/)
but here are the casting numbers. Center casting # 6H Rear port # M4 and theres another set of numbers by the valve cover B256 |
Also it has skrew in rocker studs.
The 6H head should have a 2.11" intake and a 1.66" exhaust valve, screw in studs w/guide plates. This is of small consolation, considering the 114cc-plus combustion chamber size. If you mill them, you will get about a 10cc reduction per ~0.045" removed, so you'd need to remove 0.090" to get to around 94cc- or the size that a 6X-4 head for a 400 is stock. Look over THIS page at Wallace Racing to see what the secondary ID is. They show you where to look, along w/the meaning. But I hold very little hope that the 6H will be anything but the 114cc-plus chamber 455 head. Sorry, I wish there was something better to report. |
yea the secondary code is 6 so yea there the 114cc heads. I had a machine shop do a valve job on it and they also milled the head a little, i dont know how much they took off though. Well me and my dad had been tossing around the idea of just getting some high compression pistons if the compression ratio came out to low. With some new pistons im hoping to get anywhere from 9:1 or 10:1, you think it could be done?
If the 455 heads hadn't been to the shop, it would be a much easier decision. |
Well I got these heads for free, and I know the family that owns the machine shop so i can get more taken off these heads, not to much though. And its just a project engine so i think ill just save some cash and get pistons.
Thanks for your help though! One more quick question, well guesstimation. How much will this up my HP? its just a 2bbl 350 pontiac, books say its 180-190hp going to a 4bbl quadrajet from a BBC 454 and a stock pontiac 4bbl manifold. the new heads 1.96 intakes to the 2.11 and 20cc less on the head. kinda vague but any guesses? im thinking around 240? |
I concur with cobalt. With the heads from a 455, you will still have a dog, And you won't have decent throttle responce from a 4bbl carbuator, because of the puny cam that they put in the 2bbl 350s.
Last edited by WDCreech; 07-28-2010 at 10:21 AM. |
Well...today i found some dissapointing news. there isnt really a mass produced high top piston for pontiac 350's, they would have to be custom and very expensive...
I can get a 455 for 200 bucks, all it is, is a short block though. Soposed to have new bearings and pistons etc. I would just transfer all the little things over from my 350 (oil pan, timing chain cover etc.) Good buy? |
I read over the links above and learned quite a lot. I do have few more questions. I haven't replaced the stock Pontiac rocker nuts and (bottle neck) rocker studs yet but I am looking at these after market poly locks and rocker studs from Summit and wanted to get your opinion on them. Is this what I should buy? http://www.summitracing.com/parts/MRG-920G/?rtype=10 http://www.summitracing.com/parts/ARP-134-7101/ Note the ARP rocker studs are for a Chevy and I have a POntiac 400; problem here? Can I get by with just using poly locks with stock Pontiac bottle neck rocker studs? Does the set screw on the poly locks bite into the rocker stud threads (either stock or ARP rocker studs) and effectively make the rocker stud a one adjustment item since the threads are damaged by the poly lock? By going to ARP rocker studs will this require the use of tall valve covers? Thanks, BT |
http://www.summitracing.com/parts/ARP-135-7101/ http://www.summitracing.com/parts/ARP-135-7102/ My horse power goal is 360hp. That's why I asked about using my stock bottle neck rocker studs and poly locks. At my horse power level is it necessary to use stronger rocker studs. BT |
I don't know for sure, but I would think that the shorter ones would work unless you were to run a very high lift cam. You might ask Summit Tech before you order.
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VIEWS: 3 PAGES: 1 CATEGORY: Guides POSTED ON: 5/8/2012
Range of Altecnic Series 533 Pressure Reducing Valves
Series 533 Pressure Reducing Valve - 22mm ØD Dimensions: A: 22mm B: 72.5 C: 22.5 D: 46 B E: 93 ØA ØA C E Application Pressure reducing valves are installed in residential water systems to reduce and stabilise inlet pressures from mains water supplies or boosted water systems, which generally are too high and variable for domestic appliances to function correctly. The 533 series is specially designed for hot and cold services in houses or apartments to equalise the hot or cold water supplies or both and prevent excessive pressure at outlets such as taps and showers. Design 533 pressure reducing valves have a specially shaped diaphragm to give accurate pressure regulation in response to changes in downstream pressure. The larger outlet chamber creates a low exit velocity which is effective in reducing water noise. The control stem housing of the cartridge is made from a plastic material with a low coefficient of adhesion, which reduces the probability of scale deposits forming, the main cause of pressure reducing valve malfunction. The cartridge and strainer screen are easily removed for periodic cleaning and maintenance. Valves for use with copper tube have compression ends complying with BS EN 1254-2* Construction Details Body Brass chrome plated BS EN 12165 CW617N Cover NylonPA 66GF30 Control stem DZR alloy BS EN 12165 CW602N Cartridge POM Internal components Brass BS EN 12165 CW617N Diaphragm Nitrile rubber Seals Nitrile rubber Strainer screen Stainless steel AISI 304 Technical Data Max inlet pressure: 16 bar Outlet pressure setting range: 1 to 6 bar Factory setting: 3 bar Max working temperature: 65°C Pressure gauge range: 0 to 10 bar Medium: Potable water Advanced Water Company, Unit D5 The Enterprise Centre, Off Enterprise Way, Vale Park, Evesham Worcestershire, WR11 1GS TEL: 0845 076 6144 FAX: 01386 760077 EMAIL: email@example.com


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