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1963 Messerschmitt KR200 Cabriolet This car is going to auction June 6, 2015 in Spring Grove, IL. See vanderbrinkauctions.com for details This very late F.M.R.... More
1955 Messerschmitt KR200. This car is going to auction June 6, 2015 in Spring Grove, IL. See vanderbrinkauctions.com for details This early production model is a... More
1969 Sabel Mark III Sports Racer basket case-- rare, though. Probably qualifies for vintage racing. Junk tube chassis, 140HP Corvair core, KEP adapter with... More
1929 Model 135 Franklin Victoria This is a perfect example of a 1929 Model 135 Franklin Victoria. At this time, the Franklin company had hired... More
1941 Hollywood Graham This 1941 Hollywood Graham has had a concourse restoration and has just won first place at the Graham Nationals, Best of Show,... More
Carlifornia Inc. is specialized in Europeal Classic Cars. On-site Pre-Purchase-Inspection and Classic Car Scout. We help you to find your dream car! http://carlifornia.net... More
1925 "Fedsel"-start with a '25 Ford roadster pickup body,build a frame,add some 350/350 power,cut down and modify a '58 Edsel hood and grill,add some... More
The Silver Bomb A combination of American Hot Rod attributes (muscle!) and European sports car flair distinguishes the legendary "American Special" sports racing cars of... More
1899 HEARSE THIS IS A 1800'S HORSE DRAWN FUNERAL HEARSE, WE DO NOT KNOW THE EXACT YEAR OF PRODUCTION, IT IS NOT A REPLICA IT... More
NOS 50s-80s, Moog, brakes, oil & gas filters, shocks, belts, hoses, tune-up parts, distributors, carbs, fuel & water pumps, radiator & gas caps, coil... More
BEAM: 1946 Hiawatha Doodlebug, mint correct restoration. 623-584-9144, AZ; [email]... More
SUPER modified, 1972 Malloy-built vintage race car, possibly street legal; very unique with history, 350/350, $15,000. 419-625-7749, OH.... More
LEFFLER: 1970s sprint car, complete roller, no engine or hood, torsion, quick change, much chrome, $3,500. 419-625-7749, OH.... More
TIRES, NOS, discontinued steel-belted radials, 14, 15, no longer available, Firestone, Firehawk, 205x60HR14, over 100 others, NOS, reasonable. 941-698-4215, FL.... More
LIGHTING & lamps: 7 round LED headlights, 100% brighter and 60% less current draw than halogen, $200/pair. 617-605-4165, MA; [email]; rodtiques.com... More
PICKUP bed: not fully assembled, without tailgate, never used, fits 34-38 Chevy; Dodge 4x5-1/2, $495; rear window 36-38, Mopar, $95; will send pattern seat... More
THREE 1955 Buick; four 1955 Pontiac hubs, great gift, $100 firm picked up. 718-234-5784, NY.... More
McCLUSKY/ROBINSON: 1960 vintage Sprint car, Halibrand rear end and wheels, Schroeder steering, Lehman front drive, 365 Chevy, Hilborn fuel injection & magneto, full set... More
1954 FORD F-500 complete rolling chassis, $450; 1955 Chevrolet/GMC one ton pickup Model 3800 parts truck, nearly complete, $900. Tom, 540-687-5517, VA.... More
CLASSIC car restoration shop owner retired, liquidating 25-year inventory of hardware, trim, wheels, transmissions, mechanical, electrical, rubber and weatherstripping, glass, etc; books, manuals, parts... More
WANTED: rare window shade roller and mounting escutcheons, escutcheons only will do, if roller available, at least 32 in length would be good but... More
A VARIETY of Ford, Mercury, Dodge Brothers parts, radios, engines, horns, hubcaps, heater motors, carburetors. For more information on each specific part, visit our... More
WINDSHIELDS: two touring car windshields, circa 1920, with frames, one Ford T, one double hung with mounting brakes, GM. 989-693-6843, MI.... More
SHOCKS: hydraulic, gas, air, coilover, HD, XHD, springs, coil, leaf, shackles, U-bolts, bushings, established 1936. 800-344-1966, CO; [email] **30-YR**... More
SHOCKS: hydraulic, gas, air, coilover, HD, XHD, Houdaille, springs, coil, leaf, shackles, U-bolts, bushings, established 1936. 800-344-1966, CO; [email] **30-YR**... More
SHOCKS: hydraulic, gas, air, coilover, lever action, springs, coil, leaf, shackles, U-bolts, bushings, established 1936. 800-344-1966, CO; [email] **30-YR**... More
RADIO under-the-runningboard antenna, Philco reproduction was used on many cars. 216-524-2018, OH; www.yesterdaysradio.com... More
2008 CUSTOM ex-NASCAR race car, black & yellow, used in 2012 Pit Crew Challenge, bill of sale only, $13,900. 804-732-8001, Petersburg, VA; kimmotor.com**37-YR**... More
VACUUM to electric 12-volt wiper motor conversions, available for many makes and models 1935 to late 50s, call for more information or price sheet.... More
SEAT belts: American made 50s style, chrome flip-up buckle, 22 colors, $26.95 ea. Dan's Classic, 503-234-6674, OR; www.dansclassic.com... More
SEAT belts: American made 50s style, chrome flip-up buckle, 22 colors, $26.95 ea. Dan's Classic, 503-234-6674, OR; www.dansclassic.com... More
WINDOW regulators, lower glass channels, NOS, car, truck, 1930s-50s; worlds largest dealer. Regulator Roy, 609-828-8537, NJ.**29-YR**... More
WINDOW regulators, lower glass channels, NOS, Ford, Mopar, GMC, Chevy, International; worlds largest dealer. Regulator Roy, 609-828-8537, NJ.**29-YR**... More
AUTOMATIC transmission rebuilding kits, 1946-up (except Ultramatic, Flight-pitch), includes gaskets, O-rings, lip seals, clutches (frictions, steels), sealing rings, front seal, rear seal, $145-$390; postpaid... More
FACTORY drag cars: authentic, documented Mopars, GMs and Fords, these 60s era vehicles are rare and extremely high quality. Email: [email]; www.factorylightweights.com... More
Tour shows with ease. Silent electric 3-wheeler carries 2 riders up to 550 lbs total. Travels up to 50 miles on a charge with... More


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Top 20 most wired cities for transportation New report gauges which cities make the most use of technology to support alternative transportation options. Read more>
Pay-as-you-drive insurance plans Nearly every major insurance company now offers some kind of monitoring device that rewards low-risk drivers with big car insurance discounts, especially for low mileage. Read more>
Save money on car insurance with 5 simple steps There are many ways to save on car insurance, from shopping for the best deal to looking for discounts to hiking your deductible. Here's a primer on how to cut costs. Read more>
7 fine-print secrets of cheap car insurance Are you a risky driver? Beware of hidden exclusions and limits in cheap car insurance policies. Read more>
5 pay-as-you-drive car insurance myths Misconceptions are keeping drivers from trying out new discount programs. Are you one of them? Read more>
Maximize discounts to get the cheapest car insurance Knowing the details of how car insurance discounts work will save you money on your rates. Read more>
Affordable car insurance in 5 steps Comparing car insurance quotes and knowing which car insurance discounts are available can save you money on your premiums. Read more>
A primer on student car insurance discounts A good student discount can help lower your insurance premium and give college kids and teens an incentive to hit the books. Read more>
Reduce car insurance premiums by switching insurance companies Changing to another auto insurer can help lower your rates, but be sure to cancel your current policy properly. Read more>
Keeping car insurance rates low, skills sharp for seniors A new report says that many motorists 75 or older are willing to take precautions when they realize their driving isn't what it used to be. Read more>

subset: commoncrawl


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Weekend Promo: 60% off Pirates, Colonization and other oldies but goodies at GOG!
Loading screen
Title screen
Starting out
In the wilderness
The natives are not friendly
My mushroom garden
An even less friendly native
Dang it! They broke the fence.
I entered the fencing store to buy wooden fencing.
In this store I can buy barbed wire.
The general supplies store.
Ah! Getting a recharge.
The Control Centre
Title screen and main menu
Starting location
In the Control Centre
Ordering supplies
The mushrooms aren't very big yet
Buying supplies
Oh no! An ant has struck thy fence!
Better repair the fence
Shooting at an ant that has broken through the fence
Inside another building
Title and loading screen
Key select screen
You begin here
Main Menu
Starting position
Heading for a room
One of the sub-menus
All the things you can buy
Don't be such a paranoid android
Nice cactus
The mushrooms, after that ant's been at them
Better plant some more
The fence is your defence
Watch the bug


text:
Hotel address
Leicester North ServicesA6 A46 Junction
How to reach the hotel
GPS :N 52° 41' 29.63'' W 1° 7' 35.40'' Contact the hotel
- Tel. (+44)1162674904
- Fax. (+44)01162677908
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ibis budget Leicester - hotel reviews in Leicester
Hotel code: 6595
Accorhotels.com customer reviews in partnership with TripAdvisor
"great value for money"
4th September 2013, jenny_webb, Uxbridge, United Kingdom
Stayed for 1 night with husband and kids, 2 rooms, great value and nice breakfast! Would definitely use the hotel again if we needed to stay in the area. More power points in the room would be handy as we could only find 1 per room for phone charging etc, would have been good to have one near the mirror for my hairdryer!Thanks
"Great Place To Stay"
2nd September 2013, Chesterfield
Cant fault this hotel for the money, it is clean, in a great location - next to two major roads one leading to the M1, and the Staff are as professional as any hotel I've stayed in for considerably more money. The Buffet Breakfast is good value at £4.50 pp - eat and drink as much as you like. There are also eating places 50 yards away.One particularly good point is the cost of a pet at £5 per night. Got a great nights sleep with no road noise despite the location and would recommend a stay to friends and family without hesitation
These prices may be based on different room types. Depending on the country, these prices may not include taxes, may include VAT only or may include all taxes (VAT and city tax). When prices do not include all taxes, the relevant taxes (VAT and/or city tax) will be stated in the following stages of the reservation process. The price is only guaranteed at the time of reservation.
Hotel classifications (1 to 5 stars for France) correspond to criteria laid down by local regulations.


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Hand Wrought Sterling Necklace Bracelet Albino Manca browse these categories for related items... Directory: Estate Jewelry: Silver: Arts and Crafts: Pre 1960: item # 1224928 Please refer to our stock # J1118 when inquiring.
Silverman's Selected Antiques San Antonio Texas Guest Book $565.00 |
$565. A wonderfully made sterling silver necklace and matching bracelet by noted sculptor and silversmith, Albino Manca. Born in Italy, Manca moved to NYC where he did sculpture and also worked in silver. He died in 1976. This necklace measures about 16 1/4" long and the bracelet is almost 8" long so it would accommodate a larger wrist. Necklace is marked A. Manca on the hook closure. Bracelet is marked A. Manca, Sterling and Hand Wrought near the hook closure. Very detailed, warm patina. Great to have both pieces. |
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FCPA Compliance and Ethics Report-Episode 135, Kevin Brady on the process of sales for the compliance practitioner
FCPA Compliance and Ethics Report-Episode 134, Judge Rakoff, Judge Leon and their comments on DPAs, with the FCPA Professor
MacEwen on BigLaw's 'Hollow Middle', Shaky Vereins & Dentons in China
FCPA Compliance and Ethics Report-Episode 133, The Oscars and Compliance, Part V with Jay Rosen
FCPA Compliance and Ethics Report-Episode 132-Adam Turteltaub and SCCE Europen Compliance and Ethics Institute
FCPA Compliance and Ethics Report-Episode 131, The FCPA Professor Takes a Look Back at 2014
FCPA Compliance and Ethics Report-Episode 130, The Oscars and Compliance, Part IV with Jay Rosen
Why Every Day Is Proxy Season for Public Companies
A CFIUS Roundup: Polaris Financial
Dentons Dacheng Deal Done: Will BigLaw Follow Suit?
FCPA Compliance and Ethics Report-Episode 125, The Oscars and Compliance, Part II with Jay Rosen
FCPA Compliance and Ethics Report-Episode 124, The Oscars and Compliance, Part I with Jay Rosen
FCPA Compliance and Ethics Report-Episode 123-Jim Moore on Translations as Preventative Tool in FCPA Compliance
FCPA Compliance and Ethics Report-Episode 122-with Matt Kelly on Alstom, Avon and Petrobras
FCPA Compliance and Ethics Report-Episode 121-FCPA Year in Review, Part II
MacEwen: Law Firm M&A Demands 'Cultural Due Diligence'
FCPA Compliance and Ethics Report-Episode 120-Prof. Andy Spalding on the problem of hiring family members under the FCPA
FCPA Compliance and Ethics Report-Episode 119-FCPA Year in Review, Part I
FCPA Compliance and Ethics Report-Episode 118-the Alstom FCPA Enforcement Action
Ethics and compliance training programs are typically designed for employees, and often do not address the issues and the specific responsibilities that high-level executives face daily. These leaders can pose the highest...more
Attorney David Lagasse, Member of Mintz Levin's Employment, Labor & Benefits Practice, discusses the elements that both employers and senior executives should consider when negotiating a compensation package. ...more
Although human resources professionals are not always recognized for their efforts during a corporate acquisition, the work which they do behind the scenes can often make the difference between an acquisition succeeding or...more
Many due diligence reviews in mergers, acquisitions and investments have ignored the issue of independent contractor (IC) misclassification liability. This is a difficult exposure to identify unless the legal team digs below...more
In This Issue: - Noncompete Not Aimed At Protection Of Goodwill Does Not Qualify For Sale Of Business Exception - Federal Agencies Issue Cautionary Guidance Regarding Confidentiality Of Employment...more
Exotic dancer slips and falls, negligent handling of human remains and the usual neat contracts cases -- all this and more in the BLG Monthly Update for August!...more
Two years ago Ontario pension legislation was changed to provide for new rules that will make asset transfers and the merger of two or more pension plans much simpler. These are welcome changes since it has been expensive,...more
In Shaver v. Siemens Corporation, 2012 U.S. App. LEXIS 4081 (3d Cir. Feb. 29, 2012), the U.S. Court of Appeals for the Third Circuit issued a precedent-setting opinion addressing the complex relationship between ERISA's...more
TRIP TO INDIA, VISA BULLETIN MARCH 2012, H-1B SEASON. http://www.youtube.com/watch?v=QVejVuCq-bw 1. TRIP TO INDIA 2. QUESTION ABOUT CONSULAR PROCESSING IN INDIA 3. PREFERENCE CATEGORY VISA NUMBERS 4. H-1B...more
The McCaskill-Bond Amendment to the Federal Aviation Act provides that a merger of air carriers requires the new entity to merge the seniority lists of the two carriers' employees. Republic Airways acquired Midwest Airlines,...more
In this issue: Trial Court Must Modify Injunction to Condition Relief on Union's Request to NMB for Determination of Representative of Frontier Mechanics; Second Circuit Rejects Former Flight Attendant's RLA Discharge Claim;...more
It is that time of year again! We always hear the accountants moan and groan about the approaching April 15th deadline each year but, you have to listen a bit more closely and you will hear (and see) the U.S. business...more
H-1B: The Visa of Choice for Highly Skilled Foreign Nationals in the Scientific Community. We are rapidly approaching the April 1st deadline for the filing for new H-1B visas for the 2010-2011 Fiscal Year (FY 2010-2011)....more
Recently, another aspect of the H-1B visa process has become the "site visit". H-1B employers should be familiar with the site visit process and procedure and be sure to prepare public access files for review by potential...more
Americans across the country are familiar with Wal-Mart for their "roll-back" prices and friendly service. What most people don't know is that, after their immigration scandals in 2001 and 2003, Wal-Mart has lead the...more
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It's fast, fun, free...and zero pressure. Get started.
Exclusive finds with a new theme each month.
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Stay updated with a steady stream of new info.
Vintage-print voile fashions a floaty and free-spirited top with exotically embroidered appliqué around the neckline and down the dolman sleeves.


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Fulham Football Club
- Nickname:Cottagers
- Founded:1879
- Manager:Felix Magath
- Ground:Craven Cottage
- Capacity:26,600
- Last Game: 24-Feb-2015 19:45
- Wolverhampton Wanderers3
Fulham0 - Full match report
Coleman left shell-shocked
21 Aug 2006 - 08:09:49
Fulham boss Chris Coleman admitted that his side had been swept aside by Manchester United in their 5-1 defeat at Old Trafford.
The Cottagers were 4-0 down within 19 minutes and had to endure a torrid 90 minutes against the Red Devils.
Coleman said afterwards: "They steamrollered us.
"We hardly got hold of the ball in midfield and when we did, we gave it away far too easily.
"In those circumstances, against quality like that, you are going to get punished.
"We conceded in the first ten minutes, then the wheels came off completely.
"I would like to think we will improve on that performance. I am sure we will, because the good thing is we don't play Manchester United every week."
Related Fulham News
Related Fulham News


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In all seriousness, not noticing a huge difference in pleasure or anything like that. To be blunt, the end result is the same whatever... lots of apologies and some weeping. |
#8796318, By Demikaze Norway seeking to ban circumcision
Demikaze 6,703 posts
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Registered 6 years ago


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Unfortunately it's not possible to make reservations for this hotel at this time. Click here to see nearby hotels
Saanapu, 96799 Saanapu, Samoa – Show map
Set on Virgin Cove Beach, this resort offers bungalows and villas surrounded by the tropical gardens of Saanapu Village.
Virgin Cove Lodge Saanapu is 45 minutes' drive from Faleolo international Airport and a 1 hour drive from Apia.
All accommodation features a safety deposit box and mosquito netting. Some accommodation offers a private en suite bathroom.
An array of activities can be enjoyed on site or in the surroundings, including swimming and kayaking. The property also offers free onsite parking.
We speak your language! Hotel Rooms: 15 This property has been on Booking.com since Oct 22, 2012.
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Virgin Cove Lodge's staff speaks: English
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Canoeing, Private Beach Area
Safe, Non-smoking Rooms, Designated Smoking Area
From 3:00 PM
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The Samoan Outrigger Hotel offers a pool, Wi-Fi access and accommodation with air conditioning or mosquito netting just 15 minutes' walk from downtown Apia.
Score from 53 reviews
The fale was excellent, but many were falling down, the whole area is under pressure from erosion after the Tsunami.You see the real situation, but I noted that the site now says no food or bedding available after Oct 1...so I'd say give a miss!
The feeling of the place...run-down, few other people...all a bit sad, though the natural beauty is incredible.
The area was a swamp full of mosquitoes. The expensive cottage had many louvre windows not closing. Walking anywhere was dangerous owing to neighbours 27 dogs. Only thought there was to leave but as CID conference in Apia no accom elsewhere. 2 other families there in exactly same situation. Terrible
Staff friendly
Everything, there is absolutely nothing to recommend this resort, fales in a shocking state of disrepair. Facilities badly in need of maintenance, food and drink option pretty much non existent. Mosquitoes, cockroaches and dogs have a free run of the place. The price charged is an absolute rip off, we should have been paid to stay there.
We had a fabulous time at the Resort. The staff were always pleasant and helpful and passionate about the Resort. It was exclusive and the Fale on the beach was a delight. The interaction with staff added to the experience, recommend this
Friendly staff Isolation Beautiful bungalow in front of the sea
Mosquitoes Food Neglected place
Food Beach
Resort was empty Water was dirty Rough road to get there
excellent location romantic setup good restaurant absolute commitment to please flora and fauna
very basic toilets and showers, compared to the price level
It is a beautiful location. Truly stunning. The staff were the nicest anywhere on the island. The fales were great. Its a pretty unique and special place, if you are happy with isolation or have the money to spend on a cab or hire a car to go in and out of the resort I would highly recommend a visit. Would be perfect for a group of people or a people that want peace and quiet.
It was really isolated and we had no idea that was going to be the case. We felt a little unsafe because we were the only guests there and as two females it was quite isolating. Dinner was expensive, delicious but expensive and as you have to catch a shuttle and bus or expensive cab to get anywhere else we were a captive audience and felt like we were being forced to by expensive food (there were not cheap options). They also ran out of beer after 2 and it was 7pm so we got a bit bored. There were heaps of mozzies too, my friend has an allergy so we had to leave early.


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Well what else are a father and his son meant to do on a day off?
Oh I do like to be…By Peter Ould, on July 22nd, 2010 |
LoginWisdom...They gave our Master a crown of thorns. Why do we hope for a crown of roses? Martin Luther Peter on Twitter
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From my point of view there's little more distressing in the world of animal welfare than the thought of a full-grown chimpanzee living behind bars. Even a dog's confinement galls me. But how anyone can justify such an outrage against a being so incredibly human in its psyche almost completely eludes me.
Almost, I say … because if someone could convince me that the chimps in question were undeniably vital to the limitation of a huge clot of human suffering … well, then, I could live with myself even if I had to be the one to inflict any pain or discomfort said chimps would have to endure.
In admitting to such an outrage, am I copping to my speciesist tendencies? Am I, in fact, confessing to holding the belief that animals of some stripes are more valuable than those of another?
Well, yes … I am.
Just as I'll deign to kill fleas and ticks in the service of my patients' health, submitting rodents and rabbits to scientific study is something I consider necessary to the advancement of humanity. And since I happen to be human, I have this thing about ensuring that those humans who are among my loved ones survive. Which, by extension, means that I will side with humanity over non-humanity whenever push comes to shove. And also, not-so-surprisingly, happens to mean that I value chimpanzees more than I do fleas.
Yes, chimps and other apes get bonus points in the world of scientific research. You've got to prove that the research will do lots and lots for humanity before these creatures can be used for scientific research. In fact, our collective discomfort over using chimpanzees has led to a moratorium on their use in recent years.
This can only be a good thing. We needed time to stop and think about all we'd done to these animals. We needed to look back at all the feckless research that had been committed against them in humanity's name before deciding whether we were justified in using animals who could look at us with soulful eyes for experiments that might or might not pass the ethical smell test.
But now that, as McClatchy News Service has recently reported, we're thinking of bringing the retired chimps back into service, the game is, again, altogether changed. Are we willing to accept that there are some investigative uses for these chimps that merit their ultimate sacrifice?
Chimpanzees are the lab animal veterinarian's Holy Grail and ultimate quandary. Grail because they represent the ultimate challenge when it comes to compelling the most human-like medical experience we can provide. Quandary, because, in so doing, we submit our souls to that ultimate ethical smell test.
It's not easy to be a laboratory animal veterinarian these days. Less so now that all those chimpanzees living their lives in "chimp rescue" obscurity might well be making their way to a facility near them.
What can I say but that I sure am gratified to know I won't find myself in a position to have to make an up-close and personal decision on the subject anytime soon. God willing, those ultimately charged with it will make better choices than I could.
Dr. Patty Khuly
Pic of the day: Chimpanzee by bragithor
Comments 31
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I am so completely torn regarding lab animals. What are the alternatives? Are there alternatives?
We see the videos of communities in the wild and they truly seem almost human. So much so, that putting them in cages or leg irons seems akin to slavery.
I don't know the answer, but will be interested to see comments on this subject. -
There are some alternatives, but most of them are cell cultures or computer programs, which can't mimic the thousands of chemical reactions that happen in a body every day.
Laboratory animal facilities are subject to literally, hundreds of pages of federal legislation that they must comply with. Facilities that use 'covered species' i.e., anything higher on they phylogenetic chain than rodents, get a surprise inspection from the USDA at least once a year, and the USDA can levy fines for many of the infractions.
Most laboratory animal facilites are voluntarily accredited by AAALAC.org, which holds research facilities to a higher standard than the government mandates. This is a point of pride for the institutions.
Also, when animals are mis-treated, the research results are not as reliable, so it behooves researchers to treat their animals well.
Every animal experiment is evaluated by a committee before it is performed, and a member of that committee *must* be a veterinarian, many of whom specialize in laboratory animal medicine and must sit for a rigorous exam. The protocols are reviewed to ensure they are not duplicating research that has already been done, that any surgeries use appropriate analgesia and anesthesia, etc.
Animals that are sick are treated by a veterinarian immediately. Many of the animals get better care than pets because cost isn't an issue. If an animal needs x-rays, it gets them.
For more information, look at AALAS.org, and ACLAM.org.
Thank you for letting me give you a glimpse of 'the other side' :-)
If man was the most inteligent animal on this rock I could understand the need for using the chimps for research.
Until the day we actually become that species I'll just have to give a thumbs down. -
I am opposed to all animal testing!
It is mostly used for non-health related issues. -
Do you decline to use all products and medications that were designed through animal testing?
Leave the Monkeys alone, Play with the Rat if you have too. Let me see Apes 1st Man 2nd............Oh yes thats has already been done.( Remember ) Just when I think there is a little hope, for man-kind here we go agan, showing our true colors. Shame on us all for allowing this evil to continue....This is a very touchy subject with me and all who remember our past.
I am pro animal testing, as long as the animals are treated as humanely as possible. I realize not everything done to them is good or pleasant but for me the benefits outweigh the drawbacks. I wish there was a way to avoid it completely.
Most people believe that experiments on animals are necessary for medicine and science to progress. However, this is not the case. The belief that we must experiment on animals is being challenged by a growing number of physicians and scientists who are utilizing many research methods that do not harm or kill animals.
Adult stem cell research is more effective than animal testing. You may be interested in the information provided at this link
I have what's probably an unusual stand with regards to animal testing. I hate it myself but understand that sometimes it's necessary. However, if I were Queen of the World, I would restrict it so animals are used mostly when the testing would benefit their OWN species. When I get medicines for my felines I often read the inserts that come with these and they regularly talk about the testing that was done on 20-100 cats. I can't help but think what the lives of those 20-100 cats was like (often they're euthanized during the testing) just so MY felines and those other cats lucky enough to be pets could have better lives themselves. Still - at least the cats being used in this way were used to help other members of their species. I think this is in keeping with the idea that the needs of the many, sometimes outweighs the needs of the few since the sacrifice of those 20-100 cats may help millions of pet animals. With regards to testing things for humans (who are also animals after all) I would keep with the same philosophy. Rather than use animals, I would use humans. I would have no problem using individuals given life sentences for murder or who have abused children, for lab testing. To ME it is more ethical for us to use members of our own species to benefit our species and to potentially sacrifice those individuals who have violated the moral/ethical laws we consider most sacred rather than use helpless, innocent animals. For some non-lethal research, I think human volunteers might also be fine. Today there often are people with terminal medical conditions who are desperate to get experimental drugs since they will likely die anyway. Admitting them into research studies gives them one final hope. One definite thing I would do is completely outlaw any animal testing for cosmetics or things that are not of a vital nature. To me it is beyond disgusting that we would kill or torture thousands of rabbits or some other animals just to make sure that our eye makeup or deodorants are safe.
There are more than six billion of us and I think that's plenty. In developed countries, we live on average into our late 70s, early 80s. Most of the disease we're seeing is due to lifestyle choices and butting up against the finite age of our species.
Should a lab animal have to suffer with induced type II diabetes? We already know the cause and the cure--eat less, move more. But "science" is looking for a pill to make a bazillion dollars on. What if all that money went back into physical education and high quality food in schools instead? Oh right, no profit to be made there!
If your argument is that medical research using animals must happen because it benefits humans--does it really? Or does it just benefit the wealthy people who have access to it?
Right now there are countries with an average life expectancy in the 30s. If you support testing on animals for the "benefit of our species," how about focusing on the basics like clean water and education for those truly least fortunate among us? You could really make a difference for humanity and not one ape would be harmed in the process.
Who cares if the pharmaceutical industry makes money? If they didn't, what possible reason would they have to develop new medications?
As for only the wealthy having access to medication, I work in the medical field and deal with severely disadvantaged (finally) people every day. They are not restricted from getting their meds. Pharmaceutical companies donate millions of dollars in medication to people in the US and people in other countries.
And I am confused- first you say there are more than enough humans, but then you go on to wonder why we don't do more to save more lives via clean water and other work in 3rd world countries? Shouldn't all those people just die out so they don't live too long? -
I deal with FINANCIALLY disadvantaged people not FINALLY disadvantaged people.....
Heh. They donate millions because they make billions. For every "severely disadvantaged" person you work with, there are thousands who have no access to the same drugs. The drug companies are often browbeat into making those donations. Care to remember them charging full, western pricing in Africa for AIDS drugs till famous people got involved and shamed them into dropping their prices?
I never said anything about promoting early death of anyone. My point was pretty clear, if you support medical testing on animals because it "benefits humanity" shouldn't you be just as or even more concerned about say, Haiti or a large portion of Africa, where people live in squalor and die very young for lack of access to clean water? Or are they not "humanity" too?
Drug companies should be allowed to make money. But let's be clear about what they are focused on... retarding aging for the wealthier among us, treating preventable lifestyle diseases and creating medical devices to allow the privileged among us to live longer more comfortably. There's very little "saving humanity" going on.
I really could not care less why they donate money or drugs. The people I come into contact with are in the United States and it is them I was referring to. In addition to Medicaid and Medicare, there are many many assistance plans for people to get help with their medications.
What you are asking is irrelevant. My statement was just that I support animal testing because it benefits humanity. I don't care, and didn't specify, which humans because it has no bearing on the question.
I am not naive enough to believe drug companies exist for humanitarian reasons but then again, I don't care. The world is not a fair place, there is nothing I can do to change that, and eradicating diseases and preventing palliative care and yes, enabling decadent rich Westerners to live longer is OK with me, even if not everyone gets those benefits.
Case in point, thanks.
Folks such as yourself saying you support medical testing on animals for the sake of humanity, as in all humans in total, don't really mean "humanity." You mean some subset of humans who are most important to you.
And that's totally fine.
p.s. Off topic and 100% rhetorical, but do you really believe that your medicaid patients are getting the same access and level of care as people with private insurance and money? -
Nowhere did I say that I didn't care about benefits to "all" humanity. I said exactly the opposite but acknowledged that not all humans will receive the same level of care which is inevitable.
Yes, I do believe that. Wholeheartedly and from first hand access. The people that don't get care from the facility are people with insurance but who still can't afford it due to the soaring copays and deductibles their insuranace companies specify.
People with Medicaid pay .50-$3.30 per prescription, even for the most expensive transplant or cancer meds. And even then, if they don't pay, we legally cannot prevent them from obtaining further medical services. If today I got cancer, I would almost rather prefer to be on medicaid as opposed to my private insurance. -
Most people believe that experiments on animals are necessary for medicine and science to progress. However, this is not the case. The belief that we must experiment on animals is being challenged by a growing number of physicians and scientists who are utilizing many research methods that do not harm or kill animals.
Adult stem cell research is more effective than animal testing. You may be interested in the information provided at this link
http://www.vivisectioninfo.org/humane_research.html -
did you ever watch the f/x network show 30 Days? There was Season 3, Episode 3 about Animal Rights where an avid hunter from North Carolina attempts to spend 30 days living with a vegan family in Los Angeles, while learning about animal rights causes and programs.
During this episode the vegan family takes the hunter to speak to a scientist about animal testing. I can't seem to find the episode online but if anyone has a chance check it out. The scientist had much to say on why animal testing is unnecessary -
There is no reason good enough to subject these animals to torture. None.
Want to do tests? Prisoners...plenty of em. Let people sign up for it. Also, poor people.
Why is it OK to torture animals and not people?
If torturing a bunny, chimp or dog would keep me and any of my loved ones alive, I would certainly decline. I am under no illusion that any of us are that important in the long run.
What is important is humanity's evolution beyond cruelty and seeing animals as equally deserving of life as we are. -
Just out of curiosity, what do you do when you have any medical need at all? Just treat it caveman style, i.e. not at all?
Americans for Medical Progress has a great card you can print out in order to live a cruel free life:
I hereby identify myself as a supporter of animal rights and agree to live my life in accordance with all animal rights principles. So as not to violate my animal rights principles, I hereby request that in teh event of an accident or illness, all medical treatments developed or tested in animals be withheld, including, but not limited to: blood transfusions, anesthesia, pain killers, antibiotics, insulin, vaccines, chemotherapy, coronary bypass surgery, reconstructive surgery, and or orthopedic surgery. -
One other thing- it is too bad you can't hop in a time machine and go back to Nazi Germany, a place that was much more in step with your way of thinking, just subsitute Jew/Gypsy/homosexual for poor/prisoner. The Nazis were some of the first to pass anti-vivisection and laws against animal testing. You would be in heaven!
Wow! Really!! whewwwwwww
If that is directed at me, I hardly think my comment is more inflammatory than the desire to force prisoners and the poor to have medical experiments forced on them to avoid tests on animals.
Really donna? Because you make obscenely bitchy comments on this forum, this isn't the first time. I would like to know how people voluntarily signing up for experiments is worse than forcing animals into slavery and torture. Please tell me how that makes me a Nazi? Great argument by the way, you're obviously very bright.
If you don't see how pressuring disadvantaged people to volunteer to be experimented on is wrong, I don't know what to say to you.
Also, I did not call YOU a Nazi. I said you would fit IN with the Nazis since your societal ideals dovetail so neatly.
Nazis: We think to avoid experimenting on animals, we should experiment on people we deem worthless (Jews/Poles/Gypsies).
Esmee: I think to avoid experimenting on animals, we should experiment on people I deem worthless (the poor, people in prison).
Is that clear enough for you? -
I'm unclear why being similar to humans is the criteria for special treatment. You'll stick up for another being who happens to be similar to you but not another one? That doesn't make any sense.
Your species (and race and gender) come from the happenstance of birth. To discriminate against another for not having a similar happenstance of birth is arbitrary. Much better to use an objective criteria such as the ability to suffer and feel joy and have preferences. Anyone or thing that has no preferences clearly doesn't care one way or the other if it is exploited. A rock comes to mind. Anyone who does have preferences doesn't deserve to be exploited. Chimps have preferences and therefore deserve to have their lives respected. Same with dogs. And pigs. And cows and chickens and turkeys and goats and cats. -
Dr. Khuly, many of the topics on your blog are very provocative and mind challenging, which in turn generate a lot of responses from your readers. Whether their posts are of significance or not, emotional or unattached, specific or fabrication, educational or folklore, or whatever, a thorough discussion of a "hot" topic is always welcomed by me.
I'm the first to admit my own opinion may end up being swayed, or reconfirmed, after a lengthy discussion on any number of topics. I think that's the point of a blog that allows comments from its readers though, no? This topic is a good reference to what I'm trying to relay here.
What I find to be of particular disadvantage to your readers is the lack of "recent comments" for those that want to actively engage in the discussion of a certain topic, for whatever personal benefit they derive from it.
I don't really have the time to re-read 20, or 30, or 40+ comments to find the "new ones". I'm visiting your blog less and participating less as a result, and I think that may hold true for others.
Was there a particular reason(s) the "recent comments" were discontinued in the new format? Perhaps I would have a better understanding of the vision of the blog if you could answer this for me.
Sorry for the inconvenience. We know it can be cumbersome to keep up with a discussion after it reaches a certain point. We are working on the sidebar module for "recent comments" to make it easier for our readers to follow the stream of the discussions; it should be up within the next couple of weeks. Thanks so much for being patient with our changes!
Thank you, Editorial! I did find your post quick enough. I'm glad to hear you're restoring the recent comments. On kinda the same note, the pages load very slowly for because you're pulling so many ads from other servers. Are you doing anything to optimize the page load time?
There are always a few quirks to work out after a site-wide redesign, and one of the things we are working toward is optimizing page loads so that they will get faster and faster. The page loads should have no effect on the content appearance, however, so you can start reading even as the ads are loading.


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The Arizona Attorney General's Office asked a federal judge to stay a recent bombshell ruling that threatens the state's ability to enforce all of its campaign disclosure laws.
Read More »Tag Archives: election laws
Feed SubscriptionGovernor signs bill to repeal 2013 election reform law, kills referendum
It's official: Arizonans won't get the last word on a series of controversial changes in state election law. Without comment, Gov. Jan Brewer signed legislation Thursday to repeal the 2013 law. More to the point, by repealing the law the governor killed the referendum drive that had held up enactment until the voters made the final decision.
Read More »Federal, state laws at odds on lobbyist political contributions
To curtail the inappropriate influence of money in politics, Arizona law prohibits lobbyists from contributing to lawmakers' campaign committees while the Legislature is in session.
Read More »Judge's ruling could create PAC 'free-for-all'
Every law regulating ballot measure campaigns, political action committees and possibly even candidates' campaign committees in Arizona may soon be wiped from the books, at least until the Legislature can write new ones.
Read More »Election law referendum organizers say they're 'on track,' opponents skeptical
The deadline is approaching fast but organizers of a citizen referendum drive against a wide-ranging elections bill say they're on track to get enough signatures to put HB2305 on the 2014 ballot.
Read More »Elections law supporters start second committee to defend it
The referendum effort against the state's controversial new election law is now facing a two-pronged opposition, as a second political action committee filed paperwork this week to fight the referendum.
Read More »Reagan eyes election omnibus bill
After a handful of strange snags and unprecedented situations, Sen. Michele Reagan is eying a raft of changes to Arizona's election laws.
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Hi my names cody I live in everett but work and hang in Seattle!
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Publications (17)44.25 Total impact
Article: Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.
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ABSTRACT: Pancreatic cancer (PC) is one of the most common cancers worldwide and a leading cause of cancer-related death. Discovering novel targets is a key for its therapy. Carboxypeptidase E (CPE), a subtype of the pro-protein convertases, has been shown to be upregulated in many types of cancer, yet its function in PC remains elusive. The expressions of CPE in PC cell lines and cancer patients were investigated by Western blot and qRT-PCR. In PC cell line BX-pc-3, CPE was downregulated and its effect on cancer cell proliferation, migration, cisplatin chemosensitivity, and in vivo tumor growth was analyzed by Western blot, proliferation assay, invasion assay, and in vivo transplantation, respectively. The expression of nuclear factor-kappaB (NF-κB), a possible downstream target of CPE was examined by Western blot upon CPE regulation in PC cells, and the effects of inhibiting NF-κB on PC cell invasion and proliferation were examined. CPE was significantly upregulated in PC cell lines and tumor tissues. Proliferation and invasion assays indicated that downregulation of CPE inhibited cancer cell growth and migration and increased chemosensitivity to cisplatin. Inoculation of small interfering RNA (siRNA) transfected BX-pc-3 cells into null mice demonstrated that downregulation of CPE prevented tumor growth in vivo. NF-κB was directly regulated by CPE in pancreatic cancer, and siRNA-mediated inhibition of NF-κB exerted similar anti-tumor effect as downregulating CPE. Taken together, our results demonstrate that CPE plays an important role in pancreatic cancer. Inhibition of CPE may serve as a potential target for PC therapeutics.Tumor Biology 11/2014; · 2.84 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer-related causes of death. Deregulation or dysfunction of miRNAs contribute to cancer development. In this study, we found that low miR-545 level and high RIG-I protein in PDAC tissues were both correlated with low survival rate. MiR-545 up-regulation inhibited PDAC cell lines growth and vice versa. 3'UTR of RIG-I was targeted by miR-545. Thus we concluded that low miR-545 levels in PDAC promote tumor cells growth, and this is associated with reduced survival in PDAC patients. MiR-545 exerts its effects by directly targeting RIG-1..FEBS Letters 10/2014; · 3.34 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To raise the awareness of adenosquamous carcinoma of pancreas and discuss the treatment of it. Clinical data of 80 cases of pancreas adenosquamous carcinoma patients in the Department of Pancreas Surgery of Changhai Hospital of Second Military Medical University from December 2003 to October 2011 were analyzed. The diagnose and treatment methods were discussed. There were 61 male cases and 19 female cases who aged from 28 to 81 years, with an average age of 60 years. The primary symptoms included 46 cases (57.5%) of abdominal malaise, 6 cases (7.5%) of low back pain, 4 cases (5.0%) of abdominal swelling pain with low back pain, 15 cases (18.8%) of abdominal swelling pain with jaundice, 5 cases (6.3%) of painless jaundice, 3 cases (3.8%) of significantly decreased body-weight and 1 case (1.3%) of no symptom. All the patients had been identified as pancreas tumor suffers by ultrasound, enhanced CT scan or MRI. Totally there were 43 cases of head/unciform process tumors, 15 cases of pancreas body tumors and 22 pancreas tail cases.Health situation of all cases were follow-up observed in the outpatient department or telephoned every 3 months till 24 months after the surgery. Among the 80 patients, 19 patients underwent pancreaticoduodenectomy (PD) , 19 patients received pylorus-preserving PD, with 4 cases of palliative resection and 1 case of total pancreatectomy. The volume of bleeding during the surgery varied from 50 to 3 500 ml with a blood transfusion volume varied from 0 to 4 000 ml. Consumed time for PD procedures was 90 to 260 min with 60 to 150 min for body and (or) tail resection with or without lienectomy. The mean diameter of tumor was (4.9 ± 2.2) cm. Pathological tests showed 35 cases of positive lymph nodes, adjacent organ invasion happened in 35 patients, however, nerve invasion were found in 68 cases.Eighteen cases occurred postoperative complications, including bleeding, pancreatic fistula, gastric emptying, incision fat liquefaction and infection, pleural effusion, ascites and nervous diarrhea. There were only 48 effective follow-up patients, with a loss ratio of follow-up by 40.0%, reasons for the loss includes change of contact information, refuse or unable to provide useful information by the relatives of the patients.Sixteen patients received chemotherapy, and 8 patients received radiotherapy after operation. All patients were dead in the effective follow-ups. The postoperative median survival time was 6 months (0.1 to 23.0 months). Adenosquamous carcinoma of pancreas is a rare kind of malignant tumor, nerve invasion can be found in almost all the cases. Patients with adenosquamous carcinoma of pancreas have an unfavorable prognosis. The principle treatments are surgery, radiotherapy and chemotherapy.Zhonghua wai ke za zhi [Chinese journal of surgery]. 09/2014; 52(9):658-61. - [Show abstract] [Hide abstract]
ABSTRACT: Mesenchymal stem cells (MSCs) represent a new tool for delivery of therapeutic agents to cancer sites due to their strong tropism toward tumors. Interleukin-15 (IL-15) has demonstrated a potent anti-tumor activity in various animal models as well as clinical trials. However, because of its short half-life, effective therapeutic effects usually require a high dose which often results in undesired side effects, thus new strategies for overcoming this disadvantage are needed. In this study, human MSCs were isolated from umbilical cord blood as delivery vehicles, and transduced with lentivirus vector expressing murine IL-15 (MSC-IL-15). In vitro assays of lymphocyte activation and proliferation demonstrated that IL-15 produced by MSCs was biofunctional. In syngeneic mice bearing Pan02 pancreatic tumors, systemic administration of MSC-IL-15 significantly inhibited tumor growth and prolonged the survival of tumor-bearing mice, which were associated with tumor cell apoptosis, and NK and T cell accumulation. Furthermore, we confirmed that MSC- IL-15 could migrate toward tumor and secreted IL-15 in tumor specific sites. Depletion of NK and CD8+ T cells abolished the anti-tumor activity of MSC-IL-15, suggesting that NK and CD8+ T cells play a key role for MSC-IL-15 -mediated effect. Interestingly, cured mice after MSC-IL-15 treatment were resistant to Pan02 pancreatic tumor rechallenge, and adoptive transfer of lymphocytes from cured mice also could reject Pan02 tumor inoculation in naïve mice, indicating that MSC-IL-15 induced tumor-specific T-cell immune memory response. Overall, these data supported that MSCs producing IL-15 might represent an innovative strategy for therapy of pancreatic tumor.Molecular Cancer Therapeutics 06/2014; · 5.60 Impact Factor -
Article: Growth inhibition and apoptosis induced by 6-fluoro-3-formylchromone in hepatocellular carcinoma.
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ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in human population. The 6-fluoro-3-formylchromone (FCC) has been shown to have anti-tumor activity against various tumor cells. However, the effects of FCC on HCC cell lines have not yet been reported. This study aims to research the effects of FCC on HCC and advance the understanding of the molecular mechanism. HCC cell line SMMC-7721 was treated with FCC at various concentrations (0, 2, 5, 10, and 20 mug/ml) for 24, 48 and 72 h, respectively. The proliferations of SMMC-7721 cells were measured by MTT assays. After cultured 24 hours, cell cycle distribution and apoptosis were determined by flow cytometry. However, the expression levels of PCNA, Bax and Bcl-2 were measured by western blotting after 48 hours. FCC displayed a dose- and time-dependent inhibition of the SMMC-7721 cell proliferations in vitro. It also induced apoptosis with 45.4% and caused cell accumulation in G0/G1 phase with 21.5%. PCNA and Bcl-2 expression was significantly suppressed by FCC in a dose-dependent manner (P < 0.05), while Bax expression was increased. FCC could significantly inhibit HCC cell growth in vitro through cell cycle arrest and inducing apoptosis by suppressing PCNA expression and modulating the Bax/Bcl-2 ratio.BMC Gastroenterology 04/2014; 14(1):62. · 2.11 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to investigate the role of miR-208 in the invasion and metastasis of pancreatic cancer cells and the underlying molecular mechanism. miR-208 mimic, miR-208 inhibitor and NC were transfected into pancreatic cancer cell line Bxpc3 using liposome. Transwell invasion and scratch assays were used to test cell migratory and invasive abilities. Western blotting and quantitative PCR methods were used to detect E-cadherin, fibronectin and vimentin protein and mRNA expression in pancreatic cancer cell line BxPC3 after transfection by miR-208 mimic, miR-208 inhibitor and NC. Transwell invasion and scratch assays showed that after overexpressing miR-208, pancreatic cancer cell line BxPC3 exhibited enhanced in vitro migratory and invasive abilities, while after downregulating miR-208 expression, cell migratory and invasive abilities were decreased. Western blotting and quantitative PCR showed that after overexpressing miR-208, expression of E-cadherin, an epithelial cell marker, was decreased and expression of fibronectin and vimentin, interstitial cell markers, was increased in pancreatic cancer cell line BxPC3; however, after inhibiting miR-208, increased E-cadherin expression and decreased fibronectin and vimentin expression were observed in pancreatic cancer cell line BxPC3. After overexpressing miR-208, p-AKT and p-GSK-3β expression was altered by activating AKT/GSK-3β/snail signaling pathway. miR-208 induces epithelial to mesenchymal transition of pancreatic cancer cell line BxPC3 by activating AKT/GSK-3β/snail signaling pathway and thereby promotes cell metastasis and invasion.Cell biochemistry and biophysics 03/2014; 69(2). · 3.34 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background/Aims: En bloc resection of a tumor located in the uncinate process of the pancreas is a challenging problem. The aim of this study was to analyze outcomes of modified Miwa's augmented regional pancreatoduodenectomy for patients with pancreatic cancer in the uncinate process involving the root of the mesentery. Methodology: We analyzed by summarizing the 48 cases of ductal adenocarcinoma in the uncinate process of the pancreas during January 2004 to December 2010 with Miwa's augmented regional pancreatoduodenectomy in our hospital and examined the clinical effect and safety of this procedure. Results: We performed extended pancreaticoduodenectomy combined with isolation of full-length superior mesentery artery (SMA) for 48 patients. Sixteen of the forty-eight patients were combined with PV/SMV resection and reconstruction. There was no operative death and 20 cases developed complications, including mild to severe diarrhea in 17 cases. During follow-up survey among all patients of 6 to 45 months (median 20 months), 9 died of liver metastasis, 10 died of local recurrence, and 5 died of non-tumor causes. The 1-, 2- and 3-year accumulated survival rates were 69.1%, 35.1% and 20.2%, respectively. Conclusions: Full-length SMA isolation and involved mesentery resection with extended pancreaticoduodenectomy is safe and effective.Hepato-gastroenterology 12/2012; 60(122). · 0.91 Impact Factor - The American surgeon 11/2012; 78(11):459-62. · 0.92 Impact Factor
- Cancer Science 10/2012; 103(10):Octobercover. · 3.53 Impact Factor
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ABSTRACT: Background/Aims: Pancreatic body and tail carcinoma (PBTC) is an aggressive disease with a low resectability rate. Celiac axis infiltration usually contraindicates resection. Extended distal pancreatectomy with combined en bloc celiac axis resection (DP-CAR, also named Appleby operation) was described as a new concept for the curative treatment of these tumors. The aim of this study was to analyze the results of DP-CAR in PBTC. Methodology: Analyze by summarizing the 24 cases of PBTC during October 2005 to August 2010 in the pancreatic surgery of our hospital and analyzing the clinical manifestations, surgical processing, pathological effects and survival rate of the patients. Results: The postoperative mortality rate was 0%, despite a high morbidity rate (54%). Preoperative intractable abdominal and/or back pain in all the patients was completely alleviated immediately after surgery. During the follow-up survey among all the patients of 2 to 37 months (with an average follow-up survey of 12.67 months), no patient was still alive, with the median survival of 9.25 months. Estimated overall 1- and 3-year survival rates were 46% and 4%, respectively. Conclusions: DP-CAR offers a high resectability rate without increasing the mortality rate given skilled surgical technique.Hepato-gastroenterology 07/2012; 60(121). · 0.91 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Cancer cells can metastasize throughout the body by various mechanisms, including the lymphatic system, resulting in tumor-induced lymphangiogenesis that can profoundly affect patient survival. The aim of the present study was to examine the role of lymphangiogenesis in the metastasis of pancreatic cancer to the peripheral nerve plexus. Immunohistochemistry was performed to analyze specimens obtained from 70 ductal adenocarcinoma patients. The markers used included lymphangiogenic factor vascular endothelial growth factor (VEGF)-C, the lymphatic-specific marker D2-40, and cytokeratin 19, an independent prognostic factor for pancreatic tumors. The relationship between survival rate and invasion of both the lymphatic vessels and peripancreatic nerve plexus (PNP) was evaluated, with clearly elevated lymphatic vessel density (LVD) in tissues adjacent to the cancer tissues. In fact, LVD levels were higher in adjacent tissues than in localized cancer tissues, and lymphatic vessel invasion into tissues adjacent to the tumor was significantly correlated with both PNP invasion (P = 0.005) and lymph node metastasis (P = 0.010). Correspondingly, LVD in tissues adjacent to the tumor was correlated with both invasion of lymphatic vessels surrounding the tumor (P = 0.024) and VEGF-C expression (P = 0.031); in addition, VEGF-C expression was correlated with invasion of lymphatic vessels around the tumor (P = 0.004). Survival rates were significantly lower in patients in whom there was peritumor lymphatic vessel invasion (P < 0.001), extrapancreatic nerve plexus invasion (P = 0.001), and/or lymph node metastasis (P < 0.001). Based on these results, lymphatic invasion associated with adjacent tumor growth likely contributes to the development of metastatic tumors that invade the PNP.Cancer Science 06/2012; 103(10):1756-63. · 3.53 Impact Factor - The American surgeon 03/2012; 78(3):E178-80. · 0.92 Impact Factor
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ABSTRACT: Diabetes mellitus (DM) has been reported to be associated with an increased risk of several types of cancers. However, its relationship with cholangiocarcinoma (CC), which includes intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC), remains unclear. We conducted a meta-analysis to assess the association between diabetes and the risk of CC (including ICC and ECC). We identified studies by a literature search of Medline (from 1 January 1966) and Embase (from 1 January 1974), through 30 November 2010, and by searching the reference lists of pertinent articles. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated with a random-effects model. A total of 15 articles (10 case-control and five cohort studies) were included in this study. The number of reports on DM and risk of specific cancer were as follows: CC (n=5), ECC (n=9), and ICC (n=9). Compared with those without diabetes, individuals with diabetes had an increased risk of CC (summary RRs, 1.60; 95% CI, 1.38-1.87; P=0.992 for heterogeneity), ECC (summary RRs, 1.63; 95% CIs, 1.29-2.05; P=0.005 for heterogeneity), and ICC (summary RRs, 1.97; 95% CIs, 1.57-2.46; P=0.025 for heterogeneity). The funnel plot revealed no evidence for publication bias concerning diabetes and the risk of CC (including ICC and ECC). These findings strongly support the positive link between DM and the increased risk of CC (including ICC and ECC).European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP) 08/2011; 21(1):24-31. · 2.21 Impact Factor -
Article: Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.
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ABSTRACT: MicroRNAs (miRNAs), which regulate gene expression by partial complementarity to the 3' untranslated region of their target genes, have been implicated in cancer initiation and progression. However, the molecular mechanism underlying the regulation of miRNA expression during pancreatic tumorigenesis has not been extensively reported. In this study, we first compared the miRNA expression in human pancreatic cancers and adjacent normal tissues by miRNA array and identified 12 differentially expressed miRNAs. miR-132, which is downregulated in tumors, was further studied in greater detail. Decreased expression of miR-132 was confirmed in 16 of 20 pancreatic carcinomas (P < 0.0001), compared with their respective benign tissues by TaqMan miRNA assays. miR-132 expression was remarkably influenced by promoter methylation in PANC1 and SW1990 cells. Promoter hypermethylation was observed in tumor samples but not in the normal counterparts, and the expression of miR-132 negatively correlated with its methylation status (P = 0.013). miR-132 was transcribed by RNA polymerase II, and Sp1 played a major role in miR-132 transcription. The expression of Sp1 correlated with that of miR-132 in tissues. Moreover, cancerous tissues showed significantly lower Sp1-binding affinity to the miR-132 promoter, relative to non-tumor samples. Proliferation and colony formation of pancreatic cancer cells were suppressed in cells transfected with miR-132 mimics and enhanced in cells transfected with miR-132 inhibitor by negatively regulating the Akt-signaling pathway. Our present findings illustrate the mechanism driving miR-132 downregulation and the important role of miR-132 in pancreatic cancer development.Carcinogenesis 06/2011; 32(8):1183-9. · 5.27 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: MicroRNAs (miRNAs) have emerged as important regulators in the development of pancreatic cancer and may be a valuable therapeutic application. DPC4/Smad4 is a critical tumor suppressor involved in the progression of pancreatic cancer, but few studies have been conducted to determine its relationship with miRNAs. In this study, we identify miR-421 as a potential regulator of DPC4/Smad4. We find that in human clinical specimens of pancreatic cancer miR-421 is aberrantly upregulated while DPC4/Smad4 is strongly repressed, and their levels of expression are inversely correlated. Moreover, ectopic expression of miR-421 significantly decreases DPC4/Smad4 protein level in pancreatic cancer cell lines and simultaneously promotes cell proliferation and colony formation in vitro. Our findings identify miR-421 as a potent regulator of DPC4/Smad4, which may provide a novel therapeutic strategy for treatment of DPC4/Smad4-driven pancreatic cancer.Biochemical and Biophysical Research Communications 02/2011; 406(4):552-7. · 2.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Both deregulation of tumor-suppressor genes and misexpression of microRNAs (miRNAs) have been implicated in the development of pancreatic cancer, but their relationship during this process remains less clear. Here, we report that the expression of miR-483-3p is strongly enhanced in pancreatic cancer tissues compared to side normal tissues using a miRNA-array differential analysis. Furthermore, DPC4/Smad4 is identified as a target of miR-483-3p and their expression levels are inversely correlated in human clinical specimens. Ectopic expression of miR-483-3p significantly represses DPC4/Smad4 protein levels in pancreatic cancer cell lines, and simultaneously promotes cell proliferation and colony formation in vitro. Our findings identify miR-483-3p as a potent regulator of DPC4/Smad4, which may provide a novel therapeutic strategy for the treatment of DPC4/Smad4-driven pancreatic cancer.FEBS letters 01/2011; 585(1):207-13. · 3.54 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Develop a swine model of secondary infection in severe acute pancreatitis (SAP). Twenty-seven female swine were divided into 3 groups (1-3). In the first experiment, a SAP model was developed by retrograde injection of sodium taurocholate and trypsin into the pancreatic duct. In the second experiment, the SAP model was used to develop a secondary infection model. In groups 1 to 3, 10⁸/mL or 10⁴/mL Escherichia coli or saline were respectively used to inoculate necrotic areas of the pancreas using computed tomographic guidance. Biochemical, histopathological, and imaging analyses were used to characterize disease presentation. The survival rate was 85.2% (23/27) during the course of the 9-day experiment. The secondary infection rates in groups 1 to 3 were 100% (8/8), 37.5% (3/8), and 14.3% (1/7), respectively. In group 1, the infection rate was significantly higher in comparison to the other 2 groups (χ²=4.66 and 8.14, respectively, and both P<0.05). The biochemical and histopathological parameters and computed tomographic images indicated successful development of the SAP secondary infection model. The swine model of SAP secondary infection was successfully developed using a 2-step method, which could serve as a platform for SAP studies that need complex experimental manipulations for longer time spans, especially for imaging research.Pancreas 10/2010; 40(1):114-9. · 3.01 Impact Factor
Publication Stats
127 | Citations | |
44.25 | Total Impact Points | |
Top Journals
- Hepato-gastroenterology (2)
- Cancer Science (2)
- The American surgeon (2)
- FEBS Letters (1)
- Tumor Biology (1)
Changhai Hospital, Shanghai
Shanghai, Shanghai Shi, China
Second Military Medical University, Shanghai
Shanghai, Shanghai Shi, China


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Bethenny Frankel and her new hubby Jason Hoppy were spotted on their honeymoon. And the two weren't alone. Not only did they have a Bravo crew shooting their getaway, along with the paparazzi of course, but they had a bun in the oven along for the ride too.
The trio two were spotted in the tropics of St. Barts on their post wedding trip and it apparently went well since Bethenny tweeted that "honeymoon is magical!"


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A Sign I am Alive
By Aaron_G 1 Comments
I am alive and well. I am currently finishing up my second semester at Bowling Green State University in Ohio. Currently my gaming is limited to Minecraft and a little Civilization V here and there. At home I have Assassin's Creed Brotherhood to finish up. My early thoughts on that game: First off, I do like it. But I have trouble liking it more than the second one. The game definitely feels like it was a quick game to just put out for the holiday season, maybe this will change when I finish? However, it is fun and build off the success of the second one. I can't wait to go home and finish it.
And that's about it.


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/*************************************************************************** * CopyRight (C) 2009 by Cristinel Mazarine * * Author: Cristinel Mazarine * * Contact: firstname.lastname@example.com * * * * This program is free software; you can redistribute it and/or modify * * it under the terms of the Crom Free License as published by * * the SC Crom-Osec SRL; version 1 of the License * * * * This program is distributed in the hope that it will be useful, * * but WITHOUT ANY WARRANTY; without even the implied warranty of * * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the * * Crom Free License for more details. * * * * You should have received a copy of the Crom Free License along with * * this program; if not, write to the firstname.lastname@example.com * ***************************************************************************/ using System; using System.Windows.Forms; namespace Crom.Controls.Docking { internal class Globals { /// <summary> /// dock style not set /// </summary> public const DockStyle DockNotSet = (DockStyle)Int32.MinValue; /// <summary> /// Dock style auto-hide /// </summary> public const DockStyle DockAutoHide = (DockStyle)Int32.MaxValue; } }
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67" Freestanding Gas Grill with 900 sq. in. Cooking Surface, 78,500 BTUs, 2 Stainless Steel Burners, Rear Infrared Rotisserie and Infrared Side Burner
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94" Freestanding Gas Grill with 1,395 sq. in. Cooking Area, 123,000 Total BTU, 2 Infrared Main Burners, 4 Main Burners, Infrared Rotisserie and 2-Stage Side Burner
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All dressed up for Valentine's Day, these mini frosting-filled Red Velvet Cakes, covered with a coating of melted dark chocolate-flavored candies that hardens like the covering on an ice cream bar, will remind you of Ding Dongs — those little cream-filled cakes that are once again being marketed...
As the Seattle Seahawks and the Denver Broncos face off at the first cold weather Super Bowl in an open-air stadium at New Jersey's MetLife Stadium on Sunday, you could be well ahead of the 6:30 p.m.
As area chefs and restaurants firm up what they'll offer for the Jan. 25 to Feb. 1 Hilton Head Island-Bluffton Chamber Restaurant Week, I'm reminded of my own family's restaurant and my mother's legendary Biscuit Tortoni.
Volunteers in Medicine-Hilton Head Island held its 22nd annual Lowcountry Soup Challenge on Sunday at the Westin's Hilton Head Resort & Spa.
Almost 1,300 members of the American Culinary Federation have forecasted local foods, environment sustainability, kids' meals/nutrition and gluten-free choices among the "hot" menu items for 2014.
The first time I ever tasted Italian Wedding Soup was when I lived in Pittsburgh in the early 1980s. It was served to me at the former Tivoli's Restaurant on Rodi Road in Penn Hills.
The year is coming to an end, making this the time to reveal which recipes have received the most favorable reviews.
If you planned to make an authentic Christmas pudding weeks ago, one that needed aging before it could be eaten on Christmas, and just didn't get around to it, don't worry.
For some folks, holiday plans include a roast beef dinner, along with Yorkshire pudding, for Christmas.
This is not the first time you've seen recipes here from lawyer-turned-from-scratch-baker Warren Brown. From cakes and breakfast treats and now to pies, Brown's cookbooks have proven to be imaginative, informative and full of flavorful fun.


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I have finally decided to get one of these bikes. I am stuck between getting the 20 or 22. I ride a 21in Fisher Wahoo now. I am 6'4" with 34" inseam. I have a longer torso and arms. Can anyone give me a suggestion on the right one to pick?
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10 Quick and Easy Christmas Gifts to Make
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Handy Rice Bag Warmers
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Make sure all of your friends and family stay warm on Christmas by sewing them up some Handy Rice Bag Warmers. They're soft, inexpensive to make, and are a convenient way to shake off the winter blues. This would make a great homemade Christmas gift for someone you know who's always a bit chilly, and it could be a fun little Christmas activity that your kids can help you with.
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uhh were are you getting that from?? He (i thought it was a girl) is not known by the leaf ino's dad recognizes the guy only because he saw the corpse in that captured ninja's mind. Can you really comprehend what you read??
I not gonna fully believe kakashi's dead till its been confirmed. Theres a bunch of mini Katsuya's squirming all over Konoha that its not even funny. Like fukin 5 or 6 of em just showed up , in the NICK of time, to save ino and company. Theres still a posibilty that he's gonna get saved by one.
^ he's just in really bad shape but not dead.......YET! "I'll be there soon. Key word
So no frog naruto fusion? Fine by me. Now he's gonna have to step up an be a man and learn on his own. I guess the peeping tom, konohamaru, would be the one to tell naruto wats going on. I wonder if he made a contract with the toads as well since he wants to be like naruto an all. I could see him summoning Gamatatsu. There're both childish.


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Fishing from Kayaks and Canoes | New Topic | Printer Friendly Version |
Pro Angler 14
Posted by: RockyRaab on Jan-02-13 11:13 AM (EST)
I have a Hobie Pro Angler 14. I don't use it for anything but fishing, but there is no better boat for that use. The pedal drive is silent and efficient; the boat is extremely stable. Both hands are free to cast and retrieve, except for occasional steering inputs.
It's bigger and heavier than other boats (too big and heavy to still call it a kayak, in fact) in either the 14- or new 12-foot version, but still car-toppable if you ever need to do that. It's a fishing machine worth the rather exorbitant pricetag.
Love mine.
Deck Rigging Gear | Kayak Motor Kit | Sunglasses | Overstock Outlet Foods |
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It's the start of a new year and Becoming the Capitalist has been around for nearly a year now (11 months to be exact).
I haven't done a net worth update (this is terrible) since April where I have around 85k in net worth. The goal that I find most important is building my net worth and one of the best ways that I find that keeps me on track is recording it. So here goes!
A lot has changed. I'm back after a long hiatus. I graduated college and got a job.
Investments $78,468.73
- E*Trade Investment $52,728.65
- E*Trade IRA $17,740.07
- Prosper ~3k
- Lending Club ~2.5k
- Motif Investing ~2.5k
Property $12k
- 1 cars (Honda Fit 2012) ~ $12,000
- Wells Fargo 5,000
I also need to subtract my debts. I spent $3k on credit cards this month and I currently owe $25k in student loan debt.
Thus I actually have around $67k in net assets as of the start of 2015. That's down 18k from last April. A lot of that has been tuition, putting a deposit down for the apartment I'm moving into, and not working my last semester while I was looking for a job.


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SAPs Business Process Expert Community to Support SOA
SAPs Business Process Expert Community to Support SOA
Renee Boucher Ferguson
Posted 2006-09-11
The company will announce the new community at TechEd as part of its efforts to build an ecosystem around its NetWeaver platform.
At the launch of its annual TechEd conference in Las Vegas Sept. 12, SAP will announce a new community to support the IT industrys move toward service-oriented architectures. The community will stress process integration. SAPs Business Process Expert community is intended to be a collaborative environment where business process experts can share information, experiences and best practices to leverage SAPs ERP (enterprise resource planning) software and NetWeaver platform, the company said. The whole concept of business process modeling, management, integration and analysis has really taken off over the past couple of years, as companies become more familiar withand start to utilizethe methodology behind SOA that calls for the integration of services to build composite applications, which are compilations of service-enabled application components that are pulled together to enable a specific business process.
Click here
to read about SAPs compliance partnership with Cisco.
SAP, along with its rivals Oracle and Microsoft, is heavily invested in SOA. SAP announced its ESA (enterprise services architecture) strategy in 2003, which includes componentizing its older applications and building a new suite of applications on its NetWeaver platform (which is evolving into a business process platform)a plan that is expected to be completed in 2007. Oracle and Microsoft are also building out new application suites based on SOA that sit on their respective middleware platforms. Part of SAPs ESA undertaking has been to build out an ecosystem around its integration platformone it invites companies to standardize on for services integration. SAP recently transferred one of its executives, Zia Yusuf, over to the chief ecosystem builder position.
Yusuf brings a good deal of experience to ecosystem building. His most recent effort at SAP has been the development of a corporate strategyone that included SAPs ESA path and dovetails nicely with ecosystem development. "The way to explain corporate strategy is around three key points: platform strategy, midmarket and business users," Yusuf said in an Aug. 31 interview with eWEEK. "How do you create a vibrant, profitable ecosystem around a platform? Imagine a set of three arrows in a circular pattern: adoption, co-innovation, modernization. They all feed into each other through different parts of the ecosystem and link to those three pieces of the platform strategy."
Guru Jakob Nielsen offers advice on designing applications for usability.
Click here
to watch the video.
As part of his charter to build an ecosystem around SAPs offerings, Yusuf and his team are responsible for several communities, including the Powered by NetWeaver group, which has about 1,400 ISVs involved. "The basic model there is you find the right number of ISVs and the right type of ISVs," Yusuf said. "I dont believe its a game about the volume of partners; its more about the partners who have volume. The trick is to find the right sort that binds us by horizontal area that really have the ability to innovate." Secondly, Yusuf is responsible for SAPs software developer network, which has over 500,000 active members who add to discussions relating to SAPs NetWeaver platform. He is also behind the soft launch of the BPE community, which has been in preview for the past four months and has about 30,000 initial members. The initial uptick is good news for SAP, which is in a fierce battle with Oracle, particularly, to maintain its lead as a top software providera goal that can only be achieved if other software developers, resellers and customers build around SAPs ESA strategy. "A platform is only a platform if others use itif there are ISVs on it, customers adopt it and there is a thriving activity around it," Yusuf said.
Check out eWEEK.coms for the latest news, reviews and analysis in Web services.
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Apple has plans to launch a subscription television service by Christmas this year, according to a recent report from the New York Post. The paper states that Apple wants the service to treat channels like apps, allowing the user to purchase subscriptions for either individual channels or groups of channels a la carte. Apple has long been rumored to be pitching the service to top media executives, but according to the Post, the negotiations are not going well.
read more
Federal regulators are probing Apple's plan to take a 30% cut of revenue from content subscriptions sold through its App Store, according to reports. The 30% share is the same Apple takes for music and video sales through iTunes and... Read Post
Apple is pursuing a plan to introduce a streaming TV service by Christmas this year, in spite of the "tough time" it is having bringing media and content producers on... Read Post
In an expansion of its magazine and newspaper publishing subscription models, Apple has now begun allowing publishers to offer a subscription service to users, offering them access to a bunch of games for one price, reports Bloomber... Read Post


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