text:
Mary Ann Reilly
In the current issue of Somerset Digital Art, an article I authored, Bricolage, is the first feature (pp. 6-9). It includes five works of mine.
Find me at: http://maryannreilly.blogspot.com
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Enter "February Favorite"!
Q: So how many issues of JPG magazine were produced?
A: Do you know?


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How Parents of ADD/ADHD Children Can Build Good Relationships With TeachersTeachers are an important factor in determining your ADD/ADHD child's academic success. So what can parents do to help teachers help their children?
A couple of weeks back, I was in Texas, enjoying some outstanding BBQ prepared by the football coach of a school I was visiting, when a few teachers and I had an illuminating chat. It was clear to me from the conversation that the teachers sitting at my table licking Sweet Baby Ray's from their fingers were looking forward to another opportunity...
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Oscar Romano is known to be associated with the Geno "John" Amato crime syndicate. Oscar Romano also is a member of the Vincent Delveccio crime family and working in "Bruno" Crew. Family Boss - Vincent Delveccio Underboss - Giuseppe "Gus" Esposito Consigliere - Stephano "Mouthpiece" Pazzi Capo - Carmello "C-Mellow" Gallo Enforcer - Vitale "Vino" Columbo Soldier - Pauli "Punch" Bertasselo Soldier - Cesare "Double Tap" Ropolo Soldier - Giorgio "Uncle Moon" Cancellieri Soldier - Luca "The Man" Mancini Soldier - Claudio "Jaws" Toscanni Soldier - Diego "DT" Taborelli Soldier - Brando "Juice" Alprandi Soldier - Davide "Crunch" Ottoboni
Cheese Romano is a man with a talented nose. He has the ability to sniff out different aromas almost as well as a bloodhound. Cheese can "smell fear" on a "client." He has a love for food and for the art of "discipline." It would be unfortunate to "talk" with Cheese.
If you have any information concerning this person, please contact your local "G" MAN
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Current Time: 2/28/2015 4:42:34 PM (UTC-08:00) Pacific Time (US & Canada) (12:42 AM GMT)Last Updated: 2015-01-12T06:21:51Z on 1/11/2015 10:21:51 PM (UTC-08:00) Pacific Time (US & Canada) (6:21 AM GMT) Rendered From:UnknownCoordinates are in the WGS84 datum


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Gene Cone's one-out sacrifice fly in the eighth inning broke a 3-3 tie and junior right-hander Joel Seddon pitched 2.1 scoreless innings of relief to earn his second win of the season as sixth ranked South Carolina defeated Auburn 4-3 to win the rubber game of a three-game SEC series at Plainsman Park. The Gamecocks are 30-10 and 10-8 in the SEC with Auburn falling to 22-19 and 7-11 in league play. South Carolina is in second place in the SEC Eastern Division and tied for fourth overall
Click here for the original story.
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CE activity: Barriers to Practice and Impact on Care: An Analysis of the Psychiatric Mental Health Nurse Practitioner Role.
Thank you for your participation in Barriers to Practice and Impact on Care: An Analysis of the Psychiatric Mental Health Nurse Practitioner Role, a new 0.7-hour CE activity offered by NYSNA. NYSNA members and non-members are invited to take part in this activity, and you do not need to be a resident of New York State.GOAL:
To inform the reader of the latest developments in barriers to practice for nurse practitioners in New York State.
By completion of the article, the reader should be able to:
1. Identify specific barriers to practice for nurse practitioners.
2. Discuss the opposition that exists around changes of statutory collaboration.
3. Report and discuss the implications for practice once the Nurse Practitioner Modernization Bill passes.
Please answer the questions below. Remember to complete the answer sheet on page 27 by putting the letter of your corresponding answer next to the question number. Each question has only one correct answer. A score of 80% is needed to successfully pass this posttest.
The 0.7 contact hours for this program will be offered until October 16, 2014.
1. Give three examples of barriers to practice for the nurse practitioner:
(a) Staffing ratios, complicated diagnostic tasks, lack of physician availability.
(b) State's scope of practice issues, restrictions on reimbursement, physician dominance.
(c) Physician's recommendations of practice, prescribing practices, availability of NP partners.
(d) Nurse Practitioner Modernization Bill, changing education law, the Nurse Practitioner Professional Association.
2. The name of the current New York State Nurse Practitioner Association Bill that would allow for removal of collaboration agreements:
(a) Removal of Statutory Collaboration Bill
(b) Global Signature Bill
(c) Mental Health Bill
(d) Nurse Practitioner Modernization Bill
3. A nurse practitioner (NP) can become involved in healthcare policy change by:
(a) Writing letters to legislators and asking patients to write letters in support of NP practice.
(b) Make visits to local and state legislator's offices to explain NP practice.
(c) Join a professional organization that offers political lobbying for the profession.
(d) All of the above.
4. Nurse practitioners are allowed to set up independent practices in New York State. True or False?
(a) False--A nurse practitioner cannot set up an independent practice.
(b) True--Nurse practitioners can set up an independent practice, with a collaborating physician practice agreement, meeting with the physician once a quarter for chart reviews.
(c) True--Nurse practitioners can set up an independent practice, with a collaborating physician that is available to the NP for quarterly record reviews, and for consultation at the request of the NP throughout practice.
(d) True - Nurse practitioners can set up an independent practice in New York State with a supervising physician.
5. Enrollment in psychiatric residency and nurse practitioners specializing in psychiatric mental health nursing have been on a steady increase in the past 5 years.
(a) True
(b) False
The New York State Nurses Association is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
NYSNA has nothing to declare related to this educational activity. NYSNA wishes to disclose that no commercial support was received for this educational activity.
Reader Opinion
Printer friendly Cite/link Email Feedback | |
Publication: | Journal of the New York State Nurses Association |
Date: | Mar 22, 2011 |
Words: | 521 |
Previous Article: | CE activity: increased autonomy for nurse practitioners as a solution to the physician shortage. |
Next Article: | CE activity: obesity risk in urban adolescent girls: nutritional intentions and health behavior correlates. |


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Favorite Anime
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25 of 25 episodes seen
"The world won't change with pretty words alone!" Zero
- Note that this review is on both R1 & R2. Preferably watch them both before reading this one. Code Geass starts with a story of a highly intelligent boy named Lelouch who later on become known as a British prince who can see the corruption of the current system and planning to CHANGE it. Characters: Lelouch Vi Britannia : "One must destroy before creating." The idea is reminding us the famous mythical creature, Phoenix, the beautiful bird that when gets old builds itself a nest of twigs that then ignites; both nest and bird burn fiercely and are read more
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(1936 quotes found)
"Be yourself; everyone else is already taken."
Oscar Wilde
"I don't at all like knowing what people say of me behind my back. It makes me far too conceited."
"Those with the greatest awareness have the greatest nightmares."
Mahatma Gandhi
"When we become aware that we do not have to escape our pains, but that we can mobilize them into a common search for life, those very pains are transformed from expressions of despair into signs of hope"
Henri Nouwen
"When one is in love, one always begins by deceiving one's self, and one always ends by deceiving others. That is what world calls a romance."
"He who knows others is wise. He who knows himself is enlightened."
Lao Tzu
"Knowing others is wisdom; Knowing the self is enlightenment; Mastering others requires force; Mastering the self needs strength"
"Let us not look back in anger, nor forward in fear, but around in awareness."
James Thurber
"To be aware of a single shortcoming within oneself is more useful than to be aware of a thousand in somebody else. Rather than speaking badly about people and in ways that will produce friction and unrest in their lives, we should practice a purer perception of them, and when we speak of others, speak of their good qualities."
Dalai Lama
"I have been a selfish being all my life, in practice, though not in principle."
Jane Austen


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Nuveen Investments Inc.
Watch breaking news videos and read news updates about Nuveen Investments Inc. on Crain's Chicago Business
Madison Dearborn seeking $4 billion for next buyout fund
about $4 billion for it next buyout fund after salvaging some of its boom-era investments, including a bet on Nuveen Investments Inc. that threatened to sink a prior vehicle. The Chicago-based firm plans to start gathering capital in the second
Madison Dearborn gets Nuveen millstone off its neck
most difficult investments without much to show for it. The firm is selling Chicago-based mutual fund manager Nuveen Investments Inc. for $6.25 billion to New York asset manager TIAA-CREF, which is taking on $4.5 billion of Nuveen debt
TIAA-CREF to buy Nuveen in $6.25 billion deal
(AP) — Financial services provider TIAA-CREF said it's buying Chicago-based investment manager Nuveen Investments in a deal valued at $6.25 billion including debt.
Fourth quarter pushes Nuveen into the black
Mutual fund company Nuveen Investments Inc. reported positive net income and investor inflows in the fourth quarter last year, reversing course from negative numbers on
Why Nuveen still isn't profitable
For Nuveen Investments Inc., nabbing a top stock-picker like Bob Doll (pictured at left) in late 2012, just ahead of the biggest bull market in 16
At long last, Madison Dearborn says bye-bye Boise
computer reseller it acquired in 2007 and took public again earlier this year. Still waiting for its exit cue is Nuveen Investments Inc., the Chicago-based money manager Madison Dearborn took private in another 2007 deal. As the firm begins
Nuveen funds sue insurance giant AIG
The Chicago-based funds allege that a swaps fraud related to the subprime mortgage market cost them billions of dollars in losses.
One down, one to go for Madison Dearborn
Dearborn Partners LLC, with one major piece of unfinished business. Madison Dearborn still needs an exit plan for Nuveen Investments Inc., its other megadeal from the rollicking months before financial markets went over the falls in 2007. In debt
A funk for fund managers as investors sit on the sidelines
within that asset category." Calamos is adding value and other types of investment styles to its arsenal. Nuveen Investments Inc. also reported a hiccup last summer. Although the Chicago firm's assets under management as of the end of
TransUnion sale lifts lethargic Madison Dearborn fund. Firm more than doubles its money on the deal
declines to comment. Fund V has been weighted down by two multibillion-dollar, pre-recession purchases: Nuveen Investments Inc. and computer wholesaler CDW Corp. Since 2006, its peers have averaged a 6.7 percent annualized return
TransUnion sale lifts returns — finally — for Madison Dearborn investors
for this story. Fund V has been weighted down by the two multibillion-dollar, pre-recession purchases — Nuveen Investments Inc. and computer wholesaler CDW Corp. Since 2006, its peers have averaged a 6.7 percent return. Madison Dearborn
Boss's pals get ISAC funds. Prepaid tuition plan skips usual investment scrutiny
were vetted internally by ISAC staff. Mr. Fitzgerald, a former chief investment officer at Chicago-based Nuveen Investments Inc., confirms he served as chairman of the investments committee of the Beloit College Board of Trustees in the 2000s
Hinsdale deal | Former Nuveen exec | Solar power
PwC, bought the home from Donald E. Sveen, a former senior executive with Chicago investment management firm Nuveen Investments Inc. Mr. Sveen, who retired in 1996 after 27 years with the company, was named chief operating officer in 1974
Locavore's dilemma for Madison Dearborn. Private-equity firm needs big payoff on CDW, Nuveen deals
(Crain's) — Madison Dearborn Partners LLC is testing investors' patience with negative returns on its biggest buyout fund, which includes bubble-era deals for CDW Corp. and Nuveen Investments LLC. Chicago's largest private- equity firm paid a combined $13 billion for the two Chicago-area companies
Downtown office vacancy rate drops, suggests tide is turning
(Crain's) — The beleaguered downtown office market took a turn for the better in the third quarter, as the vacancy rate dropped after rising for seven straight quarters. The overall vacancy rate fell to 17.0% from 17.3% in the second quarter, which was the highest in more than four years, according


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China May Limit Iron Ore Traders Through New Rules
Aug. 3 (Bloomberg) -- China, the world's largest buyer of iron ore, may reduce the number of qualified importers of the commodity with new rules for the steel industry soon, paving the way for mills to improve their price bargaining power.
The new rules will include standards on capital requirements, energy consumption and the environment, Luo Bingsheng, vice chairman of the China Iron & Steel Association, told reporters in Beijing today, without giving details. Iron ore is a steelmaking ingredient.
The steel association, representing China's largest mills, wants to reduce the number of licensed iron ore importers, as it blames smaller buyers for inflating prices. Restrictions, if imposed, may extend a decline in Chinese iron ore imports, which fell for three consecutive months to June.
"Traders should meet the industry's environmental and energy consumption standards and have sufficient capital," Luo said. "The rules will include detailed standards on these aspects. The number of qualified traders will probably decline, in line with those rules."
In February, the Ministry of Industry and Information Technology said it will limit iron ore traders in a new steel industry policy to be released soon. The government announced environmental and power standards for steelmakers last month, capping discharge of waste water and air emissions.
Imports Decline
Iron ore imports by China may continue to decline this quarter, Luo said. Purchases had dropped 9 percent to 47.2 million metric tons in June from May, as government measures to curb the property market damped steel demand. Imports rose 42 percent to a record 628 million tons last year.
Slowing steel demand forced 40 percent of mills to cut output or put plants on maintenance this year, Luo said, without naming companies. Costs of production have risen while steel prices have dropped since April, he said.
"Facing higher costs and lower prices, steelmakers' margins will be further reduced, so the situation this quarter is very tough," Luo said.
Domestic prices of hot-rolled coil fell for seven straight weeks to July 16. The average import costs of iron ore jumped 46.4 percent in the first half from a year ago, the steel association said.
China should reduce supplies by foreign companies to just one-third of its requirements by 2015 by boosting domestic output and investing overseas, the steel association said July 30. The nation wants to cut purchases from Vale SA, BHP Billiton Ltd. and Rio Tinto Group, which account for three-quarters of global trade, after they dropped a four-decade system of setting annual prices and raised rates twice this year.
To contact the Bloomberg News Staff of this story: Xiao Yu in Beijing at firstname.lastname@example.com;
To contact the editor responsible for this story: Andrew Hobbs at firstname.lastname@example.com


text:
Homes Photos
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- 1 Bruce Jenner buys $3.5 million Malibu mansion
- 2 Ponzi schemer Peter Madoff's Long Island home sells for $3.5
- 3 Karlie Kloss could make bank on sale of her building
- 4 Sale of Upper Manhattan site could pave way for two towers
- 5 Trophy Financial District office tower could fetch $250M
- 6 Brett Icahn wants $20K a month for his Midtown penthouse
- 7 Affordable New Jersey: Six towns near New York City that have fair home prices
- 8 Now you can live like Simon Cowell for just $11M
- 9 You can have an office at One World Trade Center for $750
- 10 Greek mogul tries to set Queens record with $5.4M apartment


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victoria west
Victoria West Soccer Camp
Generals Win Home Opener
Jordan Pacheco pitched 7 innings in a successful homecoming during the Generals' 7-2 Texas Collegiate League win over the Acadiana Cane Cutters in their home opener on Sunday night at Riverside Stadium.
Pacheco was pitching at Riverside Stadium for the first time since the 2011 season during his senior year at V
2012 Girls Basketball All DistrictTeam
Here is a list of the girls who were honored by the coaches from our area.
All-District 30-4A The MVP: Adelaide Wenzel from Victoria East
Defensive MVP: Danielle Franklin from Victoria East
Newcomer of the Year: McKenna Villegas from Calhoun
Coach of the Year: Yulonda Wimbish-North from Victoria East
The first team girls are Kenya Griffin from Victoria East and Sonya Acuna from Victoria East
Victoria West, East, and GP Golf Team District Results
On Monday and Tuesday Victoria West, East, and Gregory Portland golf teams played in the District 30-4A tournament in Gregory - Portland North Shore Country Club. They showed great sportsmanship as any golfer should and here are the results
Victoria West Golf Team
Here is a list of the Victoria West boys and girls golf team members who will be competing at districts. A big congratulations goes out to these young golfers!
Victoria West Boy's Golf
1. Trevor Vega 2
High School Golfers Ready For Regionals And State!
The other day when I was playing Riverside Golf Course, I ran into the golf coach Troy McIntosh of Victoria East. They were there practicing for the upcoming Regionals. We have some pretty good young golfers in the area and 3 schools in Victoria have kids in both the regionals and state tournaments


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Grammy Performance Pictures 2013
Vote on All of the Performances From the Grammy Awards
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Don't forget to share this with your friends!
Vote on All of the Performances From the Grammy Awards
The Grammy Awards have wrapped up at the Staples Center in Los Angeles, and we want to know your take on all the performances. Taylor Swift, Elton John, and Fun. all made appearances. What did you think of each rendition — did you love them or not? Let us know and stay tuned as we update as the show goes on!
Link Love
- This is how much Will Smith's movie earned in its first weekend — Hitfix
- Where you've seen House of Cards guest stars before — HuffPost Entertainment
- Watch Bethenny's big comeback on the Real Housewives of NYC — Vulture
- Here's what happened on the latest episode of The Walking Dead — Moviefone
- 29 character changes that would drive fans wild — Cracked
- Why your next binge-watch show should be The Following — BuddyTV
- 17 problems only Emison shippers understand — Pretty Little Liars
- This is the SNL skit that upset people — POPSUGAR Celebrity & News
Latest Entertainment


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Where to find 'brains' on menu in Toronto
- 11
- Follow
A European living in northern Ontario will be visiting Toronto this weekend. any ideas where he can find brains on a menu in Toronto. Even better if tripe, cheek, tongue, pigs head, etc ... was offered as well.
I see Tripe and brains and various organs for sale at my local Fortino's in Brampton on a regular basis.
0 -
re: sasgirl
We tried Takht e Tavoos for brunch this morning. Very busy. We had to wait for a table. Thank you for the recommendation as my guest enjoyed the kalleh pacheh. Sadly they do not serve Turkish coffee on weekends as they get too busy. What a disappointment for my out of town guest.


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to All That Jazz Salon & Day Spa,
where we are committed to pampering our guests with lots of T.L.C. We offer high quality hair, nail, & skin care services...406.542.2000
Lanza, Pureology, Kenra,(C.N.D.)Shellac gel "power polish" & Vinylux
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QUEEN for a DAY (DELUXE GIFT package...only $185
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Try our EXTREME Shine & Conditioning treatment..
Yes, we accept GRIZ U MONEY!!!
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only $29. add dip...$7= $36
bring a friend for side by side pedicures!
Deep Conditioning Treatment start at $25 help for dry, parched hair
Beach Wave permanent...starting at $95...add more for longer hair....just put professional Lanza products in and go!
Deluxe Almond Spa Pedicure includes soothing masque & more massage $55. great gift idea! GIFT CERTIFICATES can purchase securely online with pay pal
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Monday thru Friday | 9:00am-7:00pm |
Saturday | 9:00am-5:00pm |
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2100 Stephens Avenue, Suite 102
(in the Stephens Center) next to Walgreen's South
Missoula, MT. 59801
Take the Orange Street Exit, go south on Orange street turns into Stephens Avenue. We are in the Stephen's Center, at the corner of Stephens Avenue and Brooks Street Suite 102 (between Vietnam Noodle & EZ Money)
or traveling


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Chris Staples Tickets
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date city state venue 12/11/2014 Charleston SC Memminger Auditorium 12/08/2014 Somerville MA Arts at the Armory 11/07/2014 Los Angeles CA Hollywood Forever Cemetery 08/19/2014 Seattle WA Tractor Tavern Chris Staples Tour Dates 2013
date city state venue 05/12/2013 Seattle WA Columbia City Theatre 04/16/2013 Salt Lake City UT Urban Lounge 04/08/2013 Tulsa OK Sound Pony 04/05/2013 Dallas TX The Prophet Bar 04/04/2013 Austin TX Holy Mountain 02/21/2013 Orlando FL Will's Pub Chris Staples Tour Dates 2012
date city state venue 10/18/2012 Charlotte NC The Milestone Club 10/17/2012 Lynchburg VA Speakertree Records 10/16/2012 Arlington VA IOTA Club & Cafe 10/15/2012 Falls Church VA Private House Show 10/14/2012 Brooklyn NY Pete's Candy Store 10/13/2012 New York NY Rockwood Music Hall Stage 1 10/11/2012 Akron OH Musica


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Can everyone post Can everyone please post 2 or 3 pictures on here with the horses names(shownames) up to you im making a horseforum video.. thank you anneka xx i pefer action pictures but i don't mind:D |
I don't get it.........do you want two pictures of our horses, so that you can make a horse forum video?? |
yes please |
... |
thanks annika (my names anneka lol aswell) anyways whats your horses name? |
... |
.....We now have three: Annaka Annika Anneka Let me see if I can find some Action shots :wink: |
lol thanks for his name and he really is a complete stunner! lol wow i didnt no there were 3 anneka's (however you spell them lol) :d popular name:D |
please post your pictures with the horses name :D |
Rio's Kabam (aka Bam-Bam) http://i61.photobucket.com/albums/h5...taycam5022.jpg http://i61.photobucket.com/albums/h5...taycam6014.jpg |
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Club Store
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Natasha Kai- US Women's National Team (Posted: 3/7/2006)
Will March 9th be the day that Natasha Kai makes history for Hawaii?
As the US Women's National Team prepares for the opening match of the Algarve Cup against China, Natasha reflects on her road to the US National Team. In the article attached Natasha ("Tash") credits her 1st HYSA team, Kailua AA and mentions guest playing with LEAHI SOCCER CLUB. Kai actually guest played with Leahi one summer, then played the following summer as a full member of Leahi Soccer Club. She now competes with our Leahi Open Women's team when she is not competing with the US National Team. Good Luck Tash!
News Wire
Play Positive Poll: What is the most important lesson in Respecting Opponents?
U.S. Women's National Team Algarve Cup roster features 25 US Youth Soccer alums
My tips on finding the right club – Jimmy Obleda of Fullerton Rangers (CA-S)
US Youth Soccer section added to popular TopDrawerSoccer.com
What could you buy for your team with $2,500?
2015 US Youth Soccer ODP Girls Regional Teams Compete in Costa Rica


text:
Kyle Busch
Johnson shows he's still the man to beat with Atlanta win
racetracks ahead.'' While Johnson shined, NASCAR faced more questions about its safety procedures. A week ago, Kyle Busch sustained serious injuries when his car crashed head-on into an exposed concrete wall during an Xfinity Series race
Must-see TV: Why you need to tune into today's Sprint Cup race
In the last six races at Atlanta Motor Speedway, there have been six different winners: Kasey Kahne (2014), Kyle Busch (2013), Denny Hamlin (2012), Jeff Gordon (2011), Tony Stewart (2010) and Kurt Busch (2010). There's a
Kyle Busch released from hospital following foot surgery
CHARLOTTE, N.C. (AP) Kyle Busch has been released from the hospital following surgery on his left foot after breaking it during a crash at Daytona International
David Ragan, Erik Jones to replace Kyle Busch at Atlanta
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DAYTONA BEACH, Fla. (AP) Kyle Busch was injured in a scary crash late in the Xfinity Series race at Daytona International Speedway. Busch's car shot straight through
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has had run-ins with Carl Edwards, Denny Hamlin, Kyle Busch , Kevin Harvick, and most recently, Matt Kenseth and ..... fellow competitors -- as was made evident by one of Kyle Busch 's answers during Thursday's NASCAR Media Day at Daytona


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Zombie Revenge (Dreamcast)
Published by Developed by Released Also For |
100 point score based on reviews from various critics. ...
5 point score based on user ratings. |
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Court orders water projects hearings
- Published: 27 Jun 2013 at 15.31 | Viewed: 2,712 | Comments: 2
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- Writer: Online Reporters
The Central Administrative Court on Thursday ordered the government to hold public hearings before it starts on the main parts of the 350-billion-baht water management and flood infrastructure plan.
The court, however, did not order the cancellation of the whole plan as requested in a petition filed by Srisuwan Janya, chairman of the Stop Global Warming Association, and 45 residents of Bangkok, Pathum Thani and Ayutthaya provinces.
Mr Srisuwan's suit asked the court to order the Water and Flood Management Committee (WFMC) to cancel all projects until a public hearing is held.
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The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro
- H. Scholz,
- T. Lund,
- M. K. Dahle,
- J. L. Collins,
- O. Korsgren,
- J. E. Wang,
- A. Foss
- … show all 7 hide
Optimising islet culture conditions may be one strategy for reducing islet loss prior to, and immediately after, islet transplantation. Liver X receptor (LXR) agonism has previously been shown to increase insulin release from pancreatic islets and reduce inflammation in leucocytes. Our aim was to investigate whether the synthetic LXR agonist GW3965 could modulate the inflammatory status of human pancreatic islets.
Levels of pro-inflammatory cytokines and tissue factor in isolated human islets were determined by TaqMan low density array and/or real-time quantitative RT-PCR (mRNA levels) and enzyme immunoassay (EIA) (protein levels). Islet viability was measured using intracellular ATP content, ADP/ATP ratio, mitochondrial dehydrogenase activity (XTT assay) and insulin secretion in a dynamic glucose-challenge model. Apoptosis was determined by EIA measurement of histone–DNA complexes present in cytoplasm and by assaying caspase-3/-7 activity.
Treatment of LPS-stimulated human islets with the synthetic LXR agonist GW3965 (1 µmol/l) for 24 h reduced mRNA and protein levels of selected pro-inflammatory cytokines (IL-8, monocyte chemotactic protein-1 and tissue factor). Moreover, GW3965 had no adverse effect on insulin secretion, islet viability or apoptosis. No excess of lipid accumulation could be detected with the dosage and exposure time used.
LXR activation suppresses inflammation in human islets in vitro without adverse effects on islet viability. Short-term moderate activation of LXR prior to islet transplantation may represent a possible strategy for improving post-transplant islet survival.
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- Ko SH, Ryu GR, Kim S et al (2008) Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells. Transplantation 85:323–330 CrossRef
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- Bensinger SJ, Tontonoz P (2008) Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454:470–477 CrossRef
- Bradley MN, Hong C, Chen M et al (2007) Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest 117:2337–2346 CrossRef
- Riddell DR, Zhou H, Comery TA et al (2007) The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol Cell Neurosci 34:621–628 CrossRef
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- Title
- The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro
- Journal
Volume 52, Issue 7 , pp 1352-1362
- Cover Date
- 2009-07-01
- 10.1007/s00125-009-1366-z
- Print ISSN
- Online ISSN
- 1432-0428
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
- Chemokines
- Cytokines
- Human islets
- Inflammatory mediators
- Liver X receptor
- Tissue factor
- Industry Sectors
- Authors
- H. Scholz (1) (2)
- T. Lund (1) (2)
- M. K. Dahle (1)
- J. L. Collins (3)
- O. Korsgren (4)
- J. E. Wang (1)
- A. Foss (1) (2)
- Author Affiliations
- 1. Institute for Surgical Research, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway
- 2. Division of Surgery, Section of Transplantation, Oslo University Hospital, Oslo, Norway
- 3. GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA
- 4. Department of Clinical Immunology, Rudbeck Laboratory, Uppsala University Hospital, Uppsala, Sweden


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Members of the Dover Fire Department are working to repair a number of reindeer statutes that were damaged by vandals recently. Now that the holiday parade is just around the corner, the pressure is on to get them back in shape so they can pull Santa's sleigh down Central Avenue the Sunday after Thanksgiving. (Courtesy photo)
DOVER — Vandals may have seriously damaged Santa's reindeer, but they can't take away the Fire Department's holiday spirit.Capt. Paul Haas said four of the reindeer used for Santa's sleigh during the annual holiday parade were damaged after an individual or individuals broke into the parks and recreation building a few months ago. "I got an email from the head of Parks and Recreation, Gary Bannon. He is responsible for that building. He reported it to the Police Department. They investigated it, took prints and wrote up a whole report but they haven't been able to stumble upon something yet," Haas said.Lt. Marc Plante said the reindeer, which are from as far back as the 1960s, were in a number of pieces when they were first brought to Central Station. The reindeer with the most damage looked like it was hit multiple times with a two by four, Plante said, pointing to one of the deer being held together with tape and spray foam.Fire Department Engineer Eric Anderson has been working hard to get the reindeer back in tiptop shape before the parade
Capt. Paul Haas and Lt. Marc Plante of the Dover Fire Department stand with two of the reindeer being fixed before the holiday parade. Vandals destroyed a number of Santa's reindeer a few months ago. (Haas/Democrat photo)


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Study: 1 in 5 Mortgages Won't Qualify for Safe Harbor Under Dodd-Frank
An analysis of home loans showed that 1 in 5 current mortgages wouldn't meet the qualified mortgage safe harbor standard that goes into effect in January.
An analysis of home loans showed that 1 in 5 current mortgages wouldn't meet the qualified mortgage safe harbor standard that goes into effect in January.
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We've done a bunch of stories about the Consumer Financial Protection Bureau, which officially opened its doors to the public last Thursday. But there are many more aspects of the Dodd-Frank Wall Street reform act that also took effect last week, just one year after President Obama signed the bill into law. For a good,… Read More
Federal regulators have missed 80% of their deadlines for implementing the sweeping Dodd-Frank Wall Street Reform and Consumer Protection Act, according to a recent report by the law firm Davis Polk. Of the 163 rules that the government was required to write by July 21, 130 remain unfinished. The law has come under fire in… Read More
When a cashier says, "debit or credit?" the question may not mean exactly what you think it does.
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Are private education lenders being unfairly singled out by the CFPB … or is the truth somewhere in the middle?
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Adelman, JeremyOverview
Publication Timeline
Most widely held works by
Jeremy Adelman
Worldly philosopher : the odyssey of Albert O. Hirschman
by Jeremy Adelman
14 editions published between 2013 and 2014 in English and held by 619 WorldCat member libraries worldwide "Worldly Philosopher chronicles the times and writings of Albert O. Hirschman, one of the twentieth century's most original and provocative thinkers. In this gripping biography, Jeremy Adelman tells the story of a man shaped by modern horrors and hopes, a worldly intellectual who fought for and wrote in defense of the values of tolerance and change. Born in Berlin in 1915, Hirschman grew up amid the promise and turmoil of the Weimar era, but fled Germany when the Nazis seized power in 1933. Amid hardship and personal tragedy, he volunteered to fight against the fascists in Spain and helped many of Europe's leading artists and intellectuals escape to America after France fell to Hitler. His intellectual career led him to Paris, London, and Trieste, and to academic appointments at Columbia, Harvard, and the Institute for Advanced Study in Princeton. He was an influential adviser to governments in the United States, Latin America, and Europe, as well as major foundations and the World Bank. Along the way, he wrote some of the most innovative and important books in economics, the social sciences, and the history of ideas. Throughout, he remained committed to his belief that reform is possible, even in the darkest of times. This is the first major account of Hirschman's remarkable life, and a tale of the twentieth century as seen through the story of an astute and passionate observer. Adelman's riveting narrative traces how Hirschman's personal experiences shaped his unique intellectual perspective, and how his enduring legacy is one of hope, open-mindedness, and practical idealism"--
Republic of capital : Buenos Aires and the legal transformation of the Atlantic world
by Jeremy Adelman
18 editions published between 1999 and 2002 in English and held by 584 WorldCat member libraries worldwide "This Book is a Political History of economic life. Through a description of the convulsions of long term change from colony to republic in Buenos Aires, Republic of Capital explores Atlantic world transformations in the eighteenth and nineteenth centuries." "In studying the legal and political foundations of Argentine capitalism, the author shows how merchants and capitalists coped with massive political upheaval and how political writers and intellectuals sought to forge a model of liberal republicanism. Among the topics examined are the transformation of commercial law, the evolution of liberal political credos, and the saga of political and constitutional turmoil after the collapse of Spanish authority."--Jacket
Sovereignty and revolution in the Iberian Atlantic
by Jeremy Adelman
8 editions published between 2006 and 2009 in English and held by 580 WorldCat member libraries worldwide This book takes a bold new look at both Spain's and Portugal's New World empires in a trans-Atlantic context. It argues that modern notions of sovereignty in the Atlantic world have been unstable, contested, and equivocal from the start. It shows how much contemporary notions of sovereignty emerged in the Americas as a response to European imperial crises in the age of revolutions. Jeremy Adelman reveals how many modern day uncertainties about property, citizenship, and human rights were forged in an epic contest over the very nature of state power in the eighteenth and early nineteenth centuries. Sovereignty and Revolution in the Iberian Atlantic offers a new understanding of Latin American and Atlantic history, one the blurs traditional distinctions between the "imperial" and the "colonial." It shows how the Spanish and Portuguese empires responded to the pressures of rival states and merchant capitalism in the eighteenth century. As empires adapted, the ties between colonies and mother countries transformed, recreating trans-Atlantic bonds of loyalty and interests. In the end, colonies repudiated their Iberian loyalties not so much because they sought independent nationhood. Rather, as European conflicts and revolutions swept across the Atlantic, empires were no longer viable models of sovereignty-and there was less to be loyal to. The Old Regimes collapsed before subjects began to imagine new ones in their place. The emergence of Latin American nations - indeed many of our contemporary notions of sovereignty - was the effect, and not the cause, of th breakdown of European empires
Colonial legacies : the problem of persistence in Latin American history
by Jeremy Adelman
8 editions published between 1999 and 2012 in English and held by 457 WorldCat member libraries worldwide More than other Atlantic societies, Latin America is shackled to its past. This collection is an exploration of the binding historical legacies--the making of slavery, patrimonial absolutist states, backward agriculture and the imprint of the Enlightenment--with which Latin America continues to grapple. Leading writers and scholars reflect on how this heritage emerged from colonial institutions and how historians have tackled these legacies over the years, suggesting that these deep encumbrances are why the region has failed to live up to liberal-capitalist expectations. They also invit
Frontier development : land, labour, and capital on the wheatlands of Argentina and Canada, 1890-1914
by Jeremy Adelman
15 editions published between 1989 and 1994 in English and Undetermined and held by 326 WorldCat member libraries worldwide This is a scholarly and stimulating study of settlement and expansion on the frontier lands in Canada and Argentina during their golden years of the late nineteenth and early twentieth centuries. Jeremy Adelman challenges many of the assumptions made about the economic 'success' of North America and the 'failure' of Latin America. Based on extensive primary research in Argentina, Canada, and Britain, Dr Adelman's book points to the central importance of property relations in economic history. The distribution, control, and use of land, labour, and capital shaped these emerging economies. At the centre of the analysis is the development of family farming in Canada, and large estates in Argentina. Each system presented opportunities and posed costs - Argentine estates proving more efficient than hitherto argued, while Canadian farms involved high social and economic costs. The approach taken here suggests directions for future research for comparative historians
The essential Hirschman
by Albert O Hirschman
5 editions published in 2013 in English and held by 98 WorldCat member libraries worldwide The Essential Hirschman brings together some of the finest essays in the social sciences, written by one of the twentieth century's most influential and provocative thinkers. Albert O. Hirschman was a master essayist, one who possessed the rare ability to blend the precision of economics with the elegance of literary imagination. In an age in which our academic disciplines require ever-greater specialization and narrowness, it is rare to encounter an intellectual who can transform how we think about inequality by writing about traffic, or who can slip in a quote from Flaubert to reveal something surprising about taxes. The essays gathered here span an astonishing range of topics and perspectives, including industrialization in Latin America, imagining reform as more than repair, the relationship between imagination and leadership, routine thinking and the marketplace, and the ways our arguments affect democratic life. Throughout, we find humor, unforgettable metaphors, brilliant analysis, and elegance of style that give Hirschman such a singular voice. Featuring an introduction by Jeremy Adelman that places each of these essays in context as well as an insightful afterword by Emma Rothschild and Amartya Sen, The Essential Hirschman is the ideal introduction to Hirschman for a new generation of readers and a must-have collection for anyone seeking his most important writings in one book"
Trading cultures : the worlds of Western merchants : essays on authority, objectivity, and evidence
10 editions published between 2000 and 2001 in English and held by 96 WorldCat member libraries worldwide
Essays in Argentine labour history 1870-1930
by Jeremy Adelman
10 editions published in 1992 in English and held by 88 WorldCat member libraries worldwide
Los años del daguerrotipo : primeras fotografías argentinas, 1843-1870
by Jeremy Adelman
5 editions published in 1995 in Spanish and English and held by 72 WorldCat member libraries worldwide
Worlds together, worlds apart : [a history of the world]
by Robert L Tignor
2 editions published in 2014 in English and held by 21 WorldCat member libraries worldwide
Worlds Together, Worlds Apart . a history of the world from the beginnings of humankind to the present
by Robert L Tignor
1 edition published in 2008 in English and held by 20 WorldCat member libraries worldwide
Worlds together, worlds apart . from 1000 CE to the present
by Robert Tignor
1 edition published in 2011 in English and held by 17 WorldCat member libraries worldwide
Worlds together, worlds apart
by Robert L Tignor
1 edition published in 2014 in English and held by 5 WorldCat member libraries worldwide
Las pasiones y los intereses : argumentos politicos en favor del capitalismo antes de su triunfo
by Albert O Hirschman
2 editions published in 2014 in Spanish and held by 4 WorldCat member libraries worldwide
Los años del daguerrotipo : primeras fotografías argentinas, 1843-1870
2 editions published in 2009 in Spanish and held by 4 WorldCat member libraries worldwide
The measure of empire: Crisis and responsibility in postemancipation Jamaica
by Christienna D Fryar
1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide This dissertation examines a range of local and imperial administrative responses to a series of crises in Jamaica after emancipation, from roughly 1840 to 1910. It demonstrates how British authorities adopted an initial default posture of nonintervention at the outset of local crises, viewing these events as colonial problems that should largely be resolved by Jamaican authorities and charities. Any deviations from this policy were strategic calculations designed either to minimize potential embarrassment to Britain or alleviate heightened political tensions between London and Kingston. On one level, the project illuminates a range of administrative practices and moral postures that those involved in running Jamaica employed during moments of crisis and catastrophe. But on another level, the insights gleaned from these case studies explain why the post-emancipation Caribbean remains a crucial site of historical inquiry for scholars of the British Empire
Worlds Together, Worlds Apart: a history of the world, volume 2 From 1000 CE to the Present
by Robert Tignor
1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide
The politics of money in mid-nineteenth-century Argentina
by Jeremy Adelman
2 editions published between 1995 and 1998 in English and held by 2 WorldCat member libraries worldwide
Republic of capital : Buenos Aires and the legal transformation of the Atlantic world Jeremy Adelman
by Jeremy Adelman
in English and held by 1 WorldCat member library worldwide http://hdl.handle.net/2027/heb.00053
Looks like you've already won
by Ashby
2 editions published in 2005 in English and held by 1 WorldCat member library worldwide more
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Associated Subjects
Ambrotype Argentina Argentina--Buenos Aires Argentina--Pampas Autonomy and independence movements Canada Capital Capitalism Civilization Civilization, Medieval Colonial companies Colonies--Administration Colonies--Economic conditions Commerce Commerce--Social aspects Constitutional history Culture diffusion Daguerreotype Economic development Economic history Economics Economists Geography History, Modern Industrialization Intellectual life International trade Labor Land use, Rural Latin America Law Merchants Photograph collections Photography Political science Property Sovereignty Spain Tintype United States Wheat trade Working class World history


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Scotland call in five players to bolster squad ahead of Italy clash
- International
- February 23, 2015, 09:48
Vern Cotter has reinforced his Scotland RBS Six Nations squad by calling up five further players ahead of Saturday's match against Italy, Scottish Rug(...)
Scotland's injured duo David Denton and Sean Maitland to miss start of Six Nations
- International
- January 27, 2015, 10:41
Scotland have confirmed David Denton and Sean Maitland will miss the start of the RBS Six Nations through injury.Glasgow wing Maitland sustained a sho(...)
Late penalty helps France break Scottish hearts at Murrayfield
- International
- March 8, 2014, 19:04
Scotland 17 France 19: Scotland suffered last-gasp heartache as France snatched a(...)
Saint-André criticised some France players for acting like crybabies
- Rugby
- March 8, 2014, 01:00
Scotland v FrancePhilippe Saint-André criticised some of his players for acting like crybabies in Cardiff, moanin(...)
Scotland bring back Kelly Brown to face France
- International
- March 4, 2014, 11:44
Scotland skipper Kelly Brown has been recalled to the side that will take on France in Saturday's final home match of this year's Six Nations. (...)
Indifference would be the most mortal poison against not great Scots
- Rugby
- January 31, 2014, 09:00
"There is no more mortal poison than indifference". Irish Times columnist Lara Marlowe, reflecting on French President François Hollande in her piece (...)


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Out & About with the Cape Cod Times
At our September meeting the Cape Cod Times visited our monthly meeting and spent some time taking pictures of our member meeting.
At our September meeting the Cape Cod Times visited our monthly meeting and spent some time taking pictures of our member meeting.
ABWA Mission The Mission of the American Business Women's Association is to bring together businesswomen of diverse occupations and to provide opportunities for them to help themselves and others grow personally and professionally through leadership, education, networking support, and national recognition. Click on the links below for copies of our: Cape Cod Chapter Goals Cape Cod Chapter […]
In November 2014, ABWA became one of the many organizations that help keep Cape Cod Healthcare's blood bank at optimal levels.
I was going through files of our events this year-to-date, thus the multiple posts today. In December, 2014 ABWA had the absolute pleasure of hearing Donna Morris, RPM Carpets, tell her story. In the Member Spotlight was a relatively new member, Peggy Jabolonski, who shared her journey of this last year and ABWA participation in […]
ABWA February Meeting: Canceled
After careful consideration of the variable forecast, potentially freezing temperatures, road conditions, and low member/guest registration, we have decided to cancel our Tuesday, February 10th Dinner Meeting. All registrants will receive a full refund, which should post within the next 5 – 10 business days. Please let us know if you do not receive your […]
ABWA Cape Cod February 2015 Dinner Meeting
• Featuring Marjorie Sparrow and Andi Genser • Our February 10th Dinner Meeting will feature Marjorie Sparrow, founder of The Hot Chocolate Sparrow in Orleans. She will speak about the challenges of growing a business with a small team and developing and implementing a succession plan. Utilizing her nursing, public health and nutrition degrees, Marjorie […]
ABWA Cape Cod January 2015 Dinner Meeting
* Featuring Sara Cushing and Amanda Converse* Our January 13th, 2015 Dinner Meeting will feature Sara Cushing, Barnstable Town Councilor, who will speak about the importance of having women volunteers in town governments. Sara is also the Marketing Program Manager at Cape Cod Healthcare (CCHC), where she oversees the marketing communications department's production team whose clients include […]
ABWA Cape Cod December 2014 Meeting
The Cape Cod Chapter of the American BusinessWomen's Association (ABWA) will hold its monthly meeting on Tuesday, December 9th at the DoubleTree by Hilton Cape Cod, 287 Iyannough Road, Hyannis. Networking will begin at 5:30 pm with a buffet dinner at 6:00 pm in the Ivy Room. Women who are not members of ABWA are welcome to […]
Tuesday November 11th, 2014, 5:30 to 8 p.m. Featuring guest speaker Lisa Guyon, President of CCYP, who will speak about volunteerism and civic engagement. Our member spotlight will be Dina Lyons, graphic design consultant and current President of ABWA. Register for dinner The November scholarship raffle theme is "Giving Thanks." Dinner attendees, sign up here to donate raffle items […]
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Dina Lyons
Vice President
Maggie French
Heidi Grinell
Laura Lincoln
Fundraising Raffles:
Cheryl Sedaker & Kathy Paige-Smith
Fundraising Sponsorships:
Maggie French, VP
Betsy LaMond
Joan McDonald
Member Education:
Ginny Scharfenberg
Open House:
Midge Rose and Kathleen Raspallo
Andi Genser & Cindy Johnson
Pam Kukla
JoAnna Watson
Paula Hersey and Joan McDonald


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4 results for "a s trade"
NBA Short-Attention-Span Power Rankings: Oh Brother!
Chris RyanA survey of the players and teams making moves in last night's NBA action. 1. Reggie Rose In the land of the boring trade deadline day, the brother of an injured superstar making loud noises in the shadows may not be king, but he's at least going...
Blog | February 22, 2013 -
JaVale! We Take It All Back!
Chris RyanJust the other day, Denver coach George Karl compared new Nugget JaVale McGee (acquired in a trade with Washington for Nene) to Kareem Abdul-Jabbar, saying "I think he plays a little bit like Kareem, but he's a defensive Kareem more than an offensive...
Blog | March 22, 2012 -
Rankonia: The Triangle Power Rankings
Chris Ryan1. Brandon Marshall, Will Now Winter in Chicago Bill Simmons chimes on in on the Bears' big trade acquisition: "When you're an All-Pro WR on a team that's trying to do everything it can to sign Peyton Manning, only you get dumped for two third-round...
Blog | March 14, 2012 -
NBA Trade Deadline Countdown: How Crazy Can Danny Ainge Get in 52...
Chris RyanCoffee, cigarettes, automobile manufacturing, and NBA trade rumors are what made this nation great. I already had coffee today, I quit smoking a few weeks ago, and I take the subway. So let's just get into the slanderous, scandalous mongering, shall ...
Blog | January 23, 2012


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2 Replies
Latest reply:
Mar 8, 2010 6:42 PM by
Stephen Kwan
1. Re: JBoss AS crashing
Adrian Brock Mar 5, 2010 12:56 PM (in response to Stephen Kwan)http://community.jboss.org/wiki/HelpItCrashed
Its unlikely to be your WS code, more likely is some incompatibilty between your OS and the JDK
but that's only a guess. The dump will tell you more.
2. Re: JBoss AS crashing
Stephen Kwan Mar 8, 2010 6:42 PM (in response to Stephen Kwan)Thanks Adrian for pointing me in the right direction. I reinstalled the jdk but it's still crashing so we'll try and debug it in the JVM.


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"Advertising is the genie which is transforming America into a place of comfort, luxury and ease for millions."
William Allen White
"Genie in a Bottle"
Christina Aguilera
"The genie is out of the bottle, ... Once you start the trial process, you don't know where it ends. It's hard to see how it wouldn't go on forever."
Charles Schumer
"There isn't any way of putting the genie back in the bottle."
Edward MacMahon
"There is no such thing as magic. You have to be genie of your lamp."
Lily Chatterjee
"Laws fashioned after Maine may now proliferate. With the legislative genie out of the bottle and opponents in possession of model legislation that has withstood judicial scrutiny, we believe that the march of regulation over time is now inevitable."
David Veal
"The nuclear genie has escaped from the bottle again. Imposing sanctions cannot put it back in again."
Klaus Kinkel


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Antibodies blocking adhesion and matrix binding domains of laminin-332 inhibit tumor growth and metastasis in vivo.
Department of Biochemistry, University of Oulu, Oulu, Finland.
International Journal of Cancer (Impact Factor: 6.2). 05/2009; 125(8):1814-25. DOI: 10.1002/ijc.24532 Source: PubMed
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ABSTRACT: To investigate the potential role of laminin γ2 and its correlation with prognosis in patients with extrahepatic cholangiocarcinoma (CCA). Laminin γ2 expression was evaluated by immunohistochemistry in 72 extrahepatic CCA patients after surgical resection. Knockdown of laminin γ2 was achieved via small interfering RNA transfection in the extrahepatic CCA cell line QBC939. Thirty-six of 72 extrahepatic CCAs (50%) stained positive for laminin γ2 in two types of patterns: stromal staining (28/72, 39%) and cytoplasmic staining (24/72, 33%). All 16 paracancerous tissue samples showed negative staining. Both stromal and cytoplasmic laminin γ2 expressions correlated with lymph node metastasis. Kaplan-Meier analysis showed that aberrant expression of laminin γ2 correlated with poor overall survival and early recurrence. Cox regression analysis further demonstrated that laminin γ2 expression was a significant independent predictor of poor overall survival and early recurrence. Immunofluorescence staining revealed cytoplasmic expression of laminin γ2 in QBC939 cells. Knockdown of laminin γ2 significantly reduced QBC939 cell invasion and migration. Aberrant expression of laminin γ2 correlates with poor prognosis and promotes invasion in extrahepatic CCA.Journal of Surgical Research 10/2013; · 2.12 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Laminins, a large family of αβγ heterotrimeric proteins mainly found in basement membranes, are strong promoters of adhesion and migration of multiple cell types, such as tumor and immune cells, via several integrin receptors. Among laminin α (LMα) chains, α5 displays the widest tissue distribution in adult life and is synthesized by most cell types. Here, we have generated and characterized five novel monoclonal antibodies (mAbs) to the human LMα5 chain to further study the biological relevance of α5 laminins, such as laminins 511 (α5β1γ1) and 521 (α5β2γ1). As detected by ELISA, immunohistochemistry, immunoprecipitation and Western blotting, each antibody displayed unique properties when compared to mAb 4C7, the prototype LMα5 antibody. Of greatest interest, mAb 8G9, but not any other antibody, strongly inhibited α3β1/α6β1 integrin-mediated adhesion and migration of glioma, melanoma, and carcinoma cells on laminin-511 and, together with mAb 4C7, on laminin-521. Accordingly, mAb 8G9 abolished the interaction of soluble α3β1 integrin with immobilized laminins 511 and 521. Binding of mAb 8G9 to laminin-511 was unaffected by the other mAbs to the LMα5 chain but largely hindered by mAb 4E10 to a LMβ1 chain epitope near the globular domain of laminin-511. Thus, mAb 8G9 defines a novel epitope localized at or near the integrin-binding globular domain of the LMα5 chain, which is essential for cell adhesion and migration, and identifies a potential therapeutic target in malignant and inflammatory diseases.PLoS ONE 01/2013; 8(1):e53648. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Laminin γ2 (Lmγ2) chain, a subunit of laminin-332, is a typical molecular marker of invading cancer cells, and its expression correlates with poor prognosis of cancer patients. It was previously found that forced expression of Lmγ2 in cancer cells promotes their invasive growth in nude mice. However, the mechanism of the tumor-promoting activity of Lmγ2 remains unknown. Here we investigated the interaction of Lmγ2 with vascular endothelial cells. When treated with an N-terminal proteolytic fragment of γ2 (γ2pf), human umbilical vein endothelial cells (HUVECs) became markedly retracted or shrunken. The overexpression of Lmγ2 or treatment with γ2pf stimulated T-24 bladder carcinoma cells to invade into the HUVEC monolayer and enhanced their transendothelial migration in vitro. Moreover, γ2pf increased endothelial permeability in vitro and in vivo. As the possible mechanisms, γ2pf activated ERK and p38 MAPK but inactivated Akt in HUVECs. Such effects of γ2pf led to prominent actin stress fiber formation in HUVECs, which was blocked by a ROCK inhibitor. γ2pf also induced delocalization of VE-cadherin and β-catenin from the intercellular junction. As possible receptors, γ2pf interacted with heparan sulfate proteoglycans (HSPGs) on the surface of HUVECs. Moreover, we localized the active site of γ2pf to the N-terminal EGF-like repeat. These data suggest that the interaction of γ2pf with HSPGs induces cytoskeletal changes of endothelial cells, leading to the loss of endothelial barrier function and the enhanced transendothelial migration of cancer cells. These activities of Lmγ2 seem to support the aberrant growth of cancer cells. This article is protected by copyright. All rights reserved.Cancer Science 11/2013; · 3.53 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.