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Publications (42)172.78 Total impact
Article: Longitudinal study of cognitive and psychiatric functions in spinocerebellar ataxia types 1 and 2.
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ABSTRACT: The role of the cerebellum in cognition, both in healthy subjects and in patients with cerebellar diseases, is debated. Neuropsychological studies in spinocerebellar ataxia type 1 (SCA1) and type 2 (SCA2) demonstrated impairments in executive functions, verbal memory, and visuospatial performances, but prospective evaluations are not available. Our aims were to assess progression of cognitive and psychiatric functions in patients with SCA1 and SCA2 in a longitudinal study. We evaluated at baseline 20 patients with SCA1, 22 patients with SCA2 and 17 matched controls. Two subgroups of patients (9 SCA1, 11 SCA2) were re-evaluated after 2 years. We tested cognitive functions (Mini Mental State Examination, digit span, Corsi span, verbal memory, attentional matrices, modified Wisconsin Card Sorting Test, Raven Progressive Matrices, Benton test, phonemic and semantic fluency), psychiatric status (Scales for Assessment of Negative and Positive Symptoms, Hamilton Depression and Anxiety Scales), neurological conditions (Scale for Assessment and Rating of Ataxia), and functional abilities (Unified Huntington Disease Rating Scale-part IV). At baseline, SCA1 and SCA2 patients had significant deficits compared to controls, mainly in executive functions (phonemic and semantic fluencies, attentional matrices); SCA2 showed further impairment in visuospatial and visuoperceptive tests (Raven matrices, Benton test, Corsi span). Both SCA groups had higher depression and negative symptoms, particularly apathy, compared to controls. After 2 years, motor and functional disability worsened, while only attentive performances deteriorated in SCA2. This longitudinal study showed dissociation in progression of motor disability and cognitive impairment, suggesting that in SCA1 and SCA2 motor and cognitive functions might be involved with different progression rates.Journal of Neurology 10/2013; · 3.84 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Although ataxia is by definition the prominent symptom of ataxia disorders, there are various neurological signs that may accompany ataxia in affected patients. Reliable and quantitative assessment of these signs is important because they contribute to disability, but may also interfere with ataxia. Therefore we devised the Inventory of Non-Ataxia Signs (INAS), a list of neurological signs that allows determining the presence and severity of non-ataxia signs in a standardized way. INAS underwent a rigorous validation procedure that involved a trial of 140 patients with spinocerebellar ataxia (SCA) for testing of inter-rater reliability and another trial of 28 SCA patients to assess short-term intra-rater reliability. In addition, data of the ongoing EUROSCA natural history study were used to determine the reproducibility, responsiveness and validity of INAS. Inter-rater reliability and short-term test-retest reliability was high, both for the total count and for most of the items. However, measures of responsiveness, such as the smallest detectable change and the clinically important change were not satisfactory. In addition, INAS did not differentiate between subjects that were subjectively stable and those that worsened in the 2-year observation period. In summary, INAS and INAS count showed good reproducibility, but unsatisfactory responsiveness. The present analysis and published data from the EUROSCA natural history study suggest that INAS is a valid measure of extracerebellar involvement in progressive ataxia disorders. As such, it is useful as a supplement to the measures of ataxia, but not as a primary outcome measure in future interventional trials.The Cerebellum 10/2012; · 2.60 Impact Factor -
Article: Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial.
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ABSTRACT: Friedreich ataxia is a rare disease caused by GAA-trinucleotide-repeat expansions in the frataxin gene, leading to marked reduction of qualitatively normal frataxin protein. Recently, human recombinant erythropoietin was reported to increase frataxin levels in patients with Friedreich ataxia. We performed a 6-month, randomized placebo-controlled, double-blind, dose-response pilot trial to assess the safety and efficacy of erythropoietin in increasing frataxin levels. Sixteen adult patient with Friedreich ataxia were randomly assigned to erythropoietin (n = 11) or matching placebo (n = 5). All patients continued Idebenone treatment (5 mg/kg/day). Treatment consisted of a 6-month scaling-up phase, in which erythropoietin was administered intravenously at the following doses: 20,000 IU every 3 weeks, 40,000 IU every 3 weeks, and 40,000 IU every 2 weeks. Erythropoietin treatment was safe and well tolerated, but did not result in any significant hematological, clinical, or biochemical effects in Friedreich ataxia patients.Movement Disorders 03/2012; 27(3):446-9. · 5.63 Impact Factor -
Article: The natural history of spinocerebellar ataxia type 1, 2, 3, and 6: a 2-year follow-up study.
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ABSTRACT: To obtain quantitative data on the progression of the most common spinocerebellar ataxias (SCAs) and identify factors that influence their progression, we initiated the EUROSCA natural history study, a multicentric longitudinal cohort study of 526 patients with SCA1, SCA2, SCA3, or SCA6. We report the results of the 1- and 2-year follow-up visits. As the primary outcome measure we used the Scale for the Assessment and Rating of Ataxia (SARA, 0-40), and as a secondary measure the Inventory of Non-Ataxia Symptoms (INAS, 0-16) count. The annual increase of the SARA score was greatest in SCA1 (2.18 ± 0.17, mean ± SE) followed by SCA3 (1.61 ± 0.12) and SCA2 (1.40 ± 0.11). SARA progression in SCA6 was slowest and nonlinear (first year: 0.35 ± 0.34, second year: 1.44 ± 0.34). Analysis of the INAS count yielded similar results. Larger expanded repeats and earlier age at onset were associated with faster SARA progression in SCA1 and SCA2. In SCA1, repeat length of the expanded allele had a similar effect on INAS progression. In SCA3, SARA progression was influenced by the disease duration at inclusion, and INAS progression was faster in females. Our study gives a comprehensive quantitative account of disease progression in SCA1, SCA2, SCA3, and SCA6 and identifies factors that specifically affect disease progression.Neurology 08/2011; 77(11):1035-41. · 8.30 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To assess the clinical spectrum of ataxia and cerebellar oculomotor deficits in the most common spinocerebellar ataxias (SCAs), we analysed the baseline data of the EUROSCA natural history study, a multicentric cohort study of 526 patients with either spinocerebellar ataxia type 1, 2, 3 or 6. To quantify ataxia symptoms, we used the Scale for the Assessment and Rating of Ataxia (SARA). The presence of cerebellar oculomotor signs was assessed using the Inventory of Non-Ataxia Symptoms (INAS). In a subgroup of patients, in which magnetic resonance images (MRIs) were available, we correlated MRI morphometric measures with clinical signs on an exploratory basis. The SARA subscores posture and gait (items 1-3), speech (item 4) and the limb kinetic subscore (items 5-8) did not differ between the genotypes. The scores of SARA item 3 (sitting), 5 (finger chase) and 6 (nose-finger test) differed between the subtypes whereas the scores of the remaining items were not different. In SCA1, ataxia symptoms were correlated with brainstem atrophy and in SCA3 with both brainstem and cerebellar atrophy. Cerebellar oculomotor deficits were most frequent in SCA6 followed by SCA3, whereas these abnormalities were less frequent in SCA1 and SCA2. Our data suggest that vestibulocerebellar, spinocerebellar and pontocerebellar circuits in SCA1, SCA2, SCA3 and SCA6 are functionally impaired to almost the same degree, but at different anatomical levels. The seemingly low prevalence of cerebellar oculomotor deficits in SCA1 and SCA2 is most probably related to the defective saccadic system in these disorders.The Cerebellum 06/2011; 11(1):155-66. · 2.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Ataxia with oculomotor apraxia type1 (AOA1, MIM 208920) is a rare autosomal recessive disease caused by mutations in the APTX gene. We screened a cohort of 204 patients with cerebellar ataxia and 52 patients with early-onset isolated chorea. APTX gene mutations were found in 13 ataxic patients (6%). Eleven patients were homozygous for the known p.W279X, p.W279R, and p.P206L mutations. Three novel APTX mutations were identified: c.477delC (p.I159fsX171), c.C541T (p.Q181X), and c.C916T (p.R306X). Expression of mutated proteins in lymphocytes from these patients was greatly decreased. No mutations were identified in subjects with isolated chorea. Two heterozygous APTX sequence variants (p.L248M and p.D185E) were found in six families with ataxic phenotype. Analyses of coenzyme Q10 in muscle, fibroblasts, and plasma demonstrated normal levels of coenzyme in five of six mutated subjects. The clinical phenotype was homogeneous, irrespectively of the type and location of the APTX mutation, and it was mainly characterized by early-onset cerebellar signs, sensory neuropathy, cognitive decline, and oculomotor deficits. Three cases had slightly raised alpha-fetoprotein. Our survey describes one of the largest series of AOA1 patients and contributes in defining clinical, molecular, and biochemical characteristics of this rare hereditary neurological condition.Neurogenetics 04/2011; 12(3):193-201. · 2.66 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Gerstmann-Sträussler-Scheinker disease Pro102Leu (GSS102) is a rare autosomal dominant inherited prion disease due to a substitution of proline for leucine at codon 102 in the Prion Protein gene, and characterized by early walking difficulties and much later occurring dementia. We report clinical, electrophysiological and neuroradiological features of seven novel Italian cases of GSS102. The findings in our series support the thesis that early signs of GSS102 (including areflexia, ataxia, lower limb weakness, and painful dysesthesias) are likely due to a caudal myelopathic process, and suggest that GSS102 should be included among the causes of ataxia with areflexia. Moreover, our observations show that in patients with GSS102, as opposed to Friedreich's ataxia and other forms of ataxia with areflexia, nerve conduction studies and somato-sensory evoked potentials are normal, despite the presence of lower limb areflexia. Hence, in subjects with walking difficulties, the presence of lower limb areflexia without central and peripheral conduction abnormalities is highly suggestive or possibly pathognomonic of GSS102, and can easily guide the clinicians to make the diagnosis of this rare neurodegenerative disease.Journal of the neurological sciences 03/2011; 302(1-2):85-8. · 2.32 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self-assessment was compared with an interview-based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement-related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown.Movement Disorders 03/2011; 26(5):870-6. · 5.63 Impact Factor -
Article: Self-rated health status in spinocerebellar ataxia--results from a European multicenter study.
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ABSTRACT: Patient-based measures of subjective health status are increasingly used as outcome measures in interventional trials. We aimed to determine the variability and predictors of subjective health ratings in a possible target group for future interventions: the spinocerebellar ataxias (SCAs). A consecutive sample of 526 patients with otherwise unexplained progressive ataxia and genetic diagnoses of SCA1 (117), SCA2 (163), SCA3 (139), and SCA6 (107) were enrolled at 18 European referral centers. Subjective health status was assessed with a generic measure of health related quality of life, the EQ-5D (Euroqol) questionnaire. In addition, we performed a neurological examination and a screening questionnaire for affective disorders (patient health questionnaire). Patient-reported health status was compromised in patients of all genotypes (EQ-5D visual analogue scale (EQ-VAS) mean 61.45 +/- 20.8). Specifically, problems were reported in the dimensions of mobility (86.9% of patients), usual activities (68%), pain/discomfort (49.4%), depression/anxiety (46.4%), and self care (38.2%). Multivariate analysis revealed three independent predictors of subjective health status: ataxia severity, extent of noncerebellar involvement, and the presence of depressive syndrome. This model explained 30.5% of EQ-VAS variance in the whole sample and might be extrapolated to other SCA genotypes.Movement Disorders 02/2010; 25(5):587-95. · 5.63 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To determine the longitudinal metric properties of recently developed clinical assessment tools in spinocerebellar ataxia (SCA). A subset of 171 patients from the EUROSCA natural history study cohort (43 SCA1, 61 SCA2, 37 SCA3, and 30 SCA6) were examined after 1 year of follow-up. Score changes and effect size indices were calculated for clinical scales (Scale for the Assessment and Rating of Ataxia [SARA], Inventory of Non-Ataxia Symptoms [INAS]), functional tests (SCA Functional Index [SCAFI] and components), and a patient-based scale for subjective health status (EQ-5D visual analogue scale [EQVAS]). Responsiveness was determined in relation to the patient's global impression (PGI) of change and reproducibility described as retest reliability for the stable groups and smallest detectable change. Within the 1-year follow-up period, SARA, INAS, and SCAFI but not EQVAS indicated worsening in the whole group and in the groups with subjective (PGI) worsening. SCAFI and its 9-hole pegboard (9HPT) component also deteriorated in the stable groups. Standardized response means were highest for 9HPT (-0.67), SARA (0.50), and SCAFI (-0.48) with accordingly lower sample size estimates of 143, 250, or 275 per group for a 2-arm interventional trial that aims to reduce disease progression by 50%. SARA and EQVAS performed best to distinguish groups classified as worse by PGI. All scales except EQVAS reached the criterion for retest reliability. While both the Scale for the Assessment and Rating of Ataxia and the SCA Functional Index (SCAFI) (and its 9-hole pegboard component) had favorable measurement precision, the clinical relevance of SCAFI and 9-hole pegboard score changes warrants further exploration. The EQ-5D visual analogue scale proved insufficient for longitudinal assessment, but validly reflected patients' impression of change.Neurology 02/2010; 74(8):678-84. · 8.30 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The identification of the molecular basis of numerous hereditary neurological disorders allowed the feasibility of predictive genetic tests for at-risk family members. In agreement with international guidelines, we tested a protocol for a predictive test to optimize cooperation among specialists, well-being of participants, and organization of clinical activities. The psychiatrist/psychologist did not meet the at-risk subjects, but cooperated with the team, integrating psychological support for participants and clinicians. We enrolled 60 subjects at risk for Huntington disease, and 32 at risk for spinocerebellar ataxias. Seventy-two subjects (78%) continued the visit program; 55 (60%) received the genetic result, and 38 subjects (41%) completed the program. Participation and outcome were similar in both groups. Mean psychological scores were all below significant levels; however, the need for psychological support was recognized for 5 mutation carriers and a non-carrier. Our data provide a methodological example of a simple and safe procedure for a predictive test, and indicate that the clinical conference represents a good setting to handle psychosocial impact associated with disclosure of genetic results in hereditary late-onset disorders.European Neurology 01/2010; 64(1):33-41. · 1.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women had anti-Yo antibodies; two patients had anti-gliadin antibodies in the presence of celiac disease; one patient had a complex autoimmune disorder associated with anti-Ro-52/SS-A and anti-muscle-specific kinase antibodies, and a patient developed subacute cerebellar syndrome associated with the presence of a prostatic adenocarcinoma and atypical antibodies reacting both with cerebellar tissue and with the prostatic tumor. Our study confirms previous findings in paraneoplastic syndromes, and indicates that at least 10% of sporadic cerebellar ataxia may be related to immune-mediated mechanisms.European Neurology 09/2009; 62(6):356-61. · 1.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We report a rare association of spinocerebellar ataxia and motor neuron disease (MND) in a woman with genetically confirmed SCA2 who subsequently developed a rapidly progressive and fatal form of MND. Considering the rarity of these two neurological conditions, it is interesting to note that the concomitant occurrence of SCA mutations and MND have been previously observed in three cases: in one patient affected by SCA6 and two other cases with SCA2.Journal of Neurology 08/2009; 256(11):1926-8. · 3.84 Impact Factor -
Article: Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature.
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ABSTRACT: Alexander disease (AD) in its typical form is an infantile lethal leucodystrophy, characterized pathologically by Rosenthal fibre accumulation. Following the identification of glial fibrillary acidic protein (GFAP) gene as the causative gene, cases of adult-onset AD (AOAD) are being described with increasing frequency. AOAD has a different clinical and neuroradiological presentation with respect to early-onset AD, as abnormalities are mainly concentrated in the brainstem-spinal cord junction. We report detailed clinical and genetic data of 11 cases of AOAD, observed over a 4-year period, and a review of the previously reported 25 cases of genetically confirmed AOAD. In our series, onset occurred as late as age 62, and up to 71 in an affected deceased relative. Most cases appeared sporadic, but family history may be misleading. The most frequent symptoms were related to bulbar dysfunction-with dysarthria, dysphagia, dysphonia (seven patients)-, pyramidal involvement (seven patients) and cerebellar ataxia (seven patients). Four patients had palatal myoclonus. Sleep disorders were also observed (four cases). Bulbar symptoms, however, were infrequent at onset and two symptomatic patients had an almost pure pyramidal involvement. Two subjects were asymptomatic. Misdiagnosis at presentation was frequent and MRI was instrumental in suggesting the correct diagnosis by showing, in all cases, mild to severe atrophy of the medulla oblongata extending caudally to the cervical spinal cord. In ten patients, molecular studies revealed six novel missense mutations and three previously reported changes in GFAP. The last typical patient carried no definitely pathogenic mutation, but a missense variant (p.D157N), supposedly a rare polymorphism. Revision of the literature and the present series indicate that the clinical picture is not specific, but AOAD must be considered in patients of any age with lower brainstem signs. When present, palatal myoclonus is strongly suggestive. Pyramidal involvement, cerebellar ataxia and urinary disturbances are common. Less frequent findings include sleep disorders and dysautonomia. Fluctuations may occur. The course is variable, usually slowly progressive and less severe than the AD forms with earlier onset. AOAD is more common than previously thought and might even be the most common form of AD. The diagnosis is strongly suggested by MRI and confirmed by GFAP gene analysis.Brain 10/2008; 131(Pt 9):2321-31. · 10.23 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To evaluate the usefulness of functional measures in patients with spinocerebellar ataxia (SCA). We assessed three functional measures-8 m walking time (8MW), 9-hole peg test (9HPT), and PATA repetition rate-in 412 patients with autosomal dominant SCA (genotypes 1, 2, 3, and 6) in a multicenter trial. While PATA rate was normally distributed (mean/median 21.7/20.5 per 10 s), the performance times for 8MW (mean/median 10.8/7.5 s) or 9HPT (mean/median 47.2/35.0 s in dominant, 52.2/37.9 s in nondominant hand) were markedly skewed. Possible learning effects were small and likely clinically irrelevant. A composite functional index (SCAFI) was formed after appropriate transformation of subtest results. The Z-scores of each subtest correlated well with the Scale for the Assessment and Rating of Ataxia (SARA), the Unified Huntington's disease Rating Scale functional assessment, and disease duration. Correlations for SCAFI with each of these parameters were stronger (Pearson r = -0.441 to -0.869) than for each subtest alone. Furthermore, SCAFI showed a linear decline over the whole range of disease severity, while 9HPT and 8MW had floor effects with respect to SARA. Analysis of possible confounders showed no effect of genotype or study site and only minor effects of age for 8MW. The proposed functional measures and their composite SCAFI have favorable properties to assess patients with spinocerebellar ataxia.Neurology 09/2008; 71(7):486-92. · 8.30 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To identify factors that determine disease severity and clinical phenotype of the most common spinocerebellar ataxias (SCAs), we studied 526 patients with SCA1, SCA2, SCA3. or SCA6. To measure the severity of ataxia we used the Scale for the Assessment and Rating of Ataxia (SARA). In addition, nonataxia symptoms were assessed with the Inventory of Non-Ataxia Symptoms (INAS). The INAS count denotes the number of nonataxia symptoms in each patient. An analysis of covariance with SARA score as dependent variable and repeat lengths of the expanded and normal allele, age at onset, and disease duration as independent variables led to multivariate models that explained 60.4% of the SARA score variance in SCA1, 45.4% in SCA2, 46.8% in SCA3, and 33.7% in SCA6. In SCA1, SCA2, and SCA3, SARA was mainly determined by repeat length of the expanded allele, age at onset, and disease duration. The only factors determining the SARA score in SCA6 were age at onset and disease duration. The INAS count was 5.0 +/- 2.3 in SCA1, 4.6 +/- 2.2 in SCA2, 5.2 +/- 2.5 in SCA3, and 2.0 +/- 1.7 in SCA6. In SCA1, SCA2, and SCA3, SARA score and disease duration were the strongest predictors of the INAS count. In SCA6, only age at onset and disease duration had an effect on the INAS count. Our study suggests that spinocerebellar ataxia (SCA) 1, SCA2, and SCA3 share a number of common biologic properties, whereas SCA6 is distinct in that its phenotype is more determined by age than by disease-related factors.Neurology 09/2008; 71(13):982-9. · 8.30 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: In recent years, the discovery that mutations in the glial fibrillary acidic protein gene (GFAP) were responsible for Alexander disease (AD) brought recognition of adult cases. The purpose of this study was to demonstrate that MR imaging allows identification of cases of AD with adult onset (AOAD), which are remarkably different from infantile cases. In this retrospective study, brain and spinal cord MR imaging studies of 11 patients with AOAD (7 men, 4 women; age range, 26-64 years; mean age, 43.6 years), all but 1 genetically confirmed, were reviewed. Diffusion and spectroscopic investigations were available in 6 patients each. Atrophy and changes in signal intensity in the medulla oblongata and upper cervical spinal cord were present in 11 of 11 cases and were the diagnostic features of AOAD. Minimal to moderate supratentorial periventricular abnormalities were seen in 8 patients but were absent in the 3 oldest patients. In these patients, postcontrast enhancement was also absent. Mean diffusivity was not altered except in abnormal white matter (WM). Increase in myo-inositol (mIns) was also restricted to abnormal periventricular WM. Awareness of the MR pattern described allows an effective selection of the patients who need genetic investigations for the GFAP gene. This MR pattern even led to identification of asymptomatic cases and should be regarded as highly characteristic of AOAD.American Journal of Neuroradiology 07/2008; 29(6):1190-6. · 3.17 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: In Parkinson's disease (PD), the motor dysfunction caused by degeneration of the nigrostriatal pathway is often associated with alterations of pain perception. This is likely related to the role that the nigrostriatal system may play in the processing of noxious, somatosensory stimuli. To further address this issue, we used a rodent model of PD, based on the unilateral, intrastriatal injection of neurotoxin 6-hydroxydopamine (6-OHDA). We investigated the effects of the nigrostriatal lesion on behavioral responses to pain tests designed to explore different aspects of nociception, such as the formalin test and the tail flick test; we also explored modifications in the expression of Fos protein, a marker of neuronal activation, in supraspinal nuclei involved in the integration of pain perception and stress-related behavior. Rats bearing the nigrostriatal lesion showed complex alterations in pain perception, including hyperalgesic responses to the tonic, inflammatory pain elicited by formalin injection, but only when the stimulus was delivered ipsilaterally to the lesion. This phenomenon was associated with delayed responses to the phasic, thermal stimulus induced by the tail flick test. The hyperalgesic response to the formalin test was accompanied by reduced Fos expression in the paraventricular nucleus of the hypothalamus, which is part of a network (the medial pain system) that mediates motivational-affective aspects of pain. Our results confirm that a unilateral alteration of central dopaminergic transmission disrupts the neural mechanisms underlying proper integration of painful stimuli, particularly in the hemibody ipsilateral to the dopaminergic denervation.Brain research 11/2007; 1176:53-61. · 2.83 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Structural MR imaging does not enable reliable differentiation of spinocerebellar ataxia (SCA) types 1 and 2 (SCA1 and SCA2), and imaging may be normal during the first years after the onset of symptoms. We aimed at determining whether measurements of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) may enable their differentiation. We enrolled 14 patients with SCA1, 11 with SCA2, and 9 age-matched controls. Diffusion tensor imaging (DTI) was performed on a 1.5T scanner, with b = 1000s/mm2 and 12 directions. ADC and FA were measured by means of regions of interest, positioned in the corticospinal tract at the level of the cerebral peduncle and at the level of the pons, in the transverse pontine fibers, in the superior and middle cerebellar peduncle, and in the hemispheric cerebellar white matter. With respect to controls, the ADC was significantly elevated in the middle cerebellar peduncle and in hemispheric white matter in SCA1, and in all regions under consideration in SCA2. It was significantly higher in SCA2 than in SCA1 in all regions under consideration. With respect to controls, the FA was significantly reduced in all regions under consideration in SCA1 and in SCA2. It was significantly lower in SCA2 than in SCA1 in the transverse pontine fibers and in the corticospinal tract at the level of the cerebral peduncle. Correlations with clinical scores were found. DTI did not enable differentiation between SCA1 and SCA2. However, strongly significant differences between the 2 subtypes and with respect to controls and correlations with clinical scores were found.American Journal of Neuroradiology 11/2007; 28(10):1996-2000. · 3.68 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: SCA17 is a rare type of autosomal dominant spinocerebellar ataxia caused by a CAG/CAA expansion in the gene encoding the TATA-binding protein (TBP). We screened for triplet expansion in the TBP gene 110 subjects with progressive cerebellar ataxia and 94 subjects with Huntington-like phenotype negative at specific molecular tests. SCA17 mutation-positive subjects were found in both groups of patients. Expanded alleles with > or = 44 CAG/CAA repeats were identified in 11 individuals and in 4 non-symptomatic relatives. Eleven de novo diagnosed patients and four patients previously reported underwent extensive clinical, neuroradiological and oculographic examination. Cerebellar signs and symptoms were present in all cases; 80% of the patients had mild to severe cognitive deficits; 66% of patients showed choreic movements; pyramidal signs, bradykinesia and dystonia were observed in approx 50% of the cases. MRI demonstrated cortical and cerebellar atrophy in all patients, whereas neurophysiological examination excluded signs of peripheral nervous system involvement. Oculographic examinations were performed in 9 out of 15 patients and showed a distinct pattern of oculomotor abnormalities, characterized by impairment of smooth pursuit, defects in the saccade accuracy, normal saccade velocity, hyperreflexia of vestibuloocular reflexes, and absence of nystagmus. In summary, this study presents one of the largest series of SCA17 patients in Europe. In our group of patients, SCA17 represents the third most frequent SCA genotype. Our clinical data confirm the large variability in SCA17 phenotypic presentation, and indicate that a peculiar combination of neuroradiological, electrophysiological and oculomotor findings is recognizable in SCA17.Journal of Neurology 11/2007; 254(11):1538-46. · 3.84 Impact Factor
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Top Journals
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- Division of Genetics of Neurodegenerative and Metabolic Illnesses
Milano, Lombardy, Italy
University of Bonn
- Department of Neurobiology
Bonn, North Rhine-Westphalia, Germany
IRCCS Fondazione Istituto Neurologico Nazionale C. Mondino
Ticinum, Lombardy, Italy
University of Insubria
Varese, Lombardy, Italy
Università degli Studi dell'Insubria
- Department of Clinical and Experimental Medicine
Varese, Lombardy, Italy


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In her own words: living with premenstrual syndrome (PMS)
Regina is a 33-year-old stay-at home mom. She home-schools her three children, takes care of animals (2 dogs, 4 guinea pigs, 5 chickens), and has been married for 13 years.
What was your first sign that something was wrong? What symptoms did you experience?
I first knew that I wasn't feeling myself about four years ago, after the birth of our third child. I had a hard time making decisions and always felt a little disoriented and confused. I would also occasionally wake up with anxiety attacks, and felt emotional and bloated most of the month.
While we were trying to get pregnant with the kids, I always kept a daily chart of my cycles and moods. I continued this chart, and began to notice a discernible monthly pattern to my moods. Two or three days after the ending of my cycle, I would feel progressively worse until the onset of my next cycle. It seemed I only had a few good days a month when I would feel in control and normal. Over the past four years, the symptoms grew worse, and so did my fears.
Since I didn't understand what was happening, I was afraid to tell my friends and family, which only worsened my anxiety. I was also afraid to discuss these symptoms with my OB/GYN, because I was afraid he would prescribe an anti-depressant, and I didn't want to go on medication.
What was the diagnosis experience like?
I saw my OB/GYN doctor first—I brought it up during my yearly routine exam. I was pleased that he was very sympathetic and a good listener, and quick to check my thyroid first for imbalances. But after the tests came back normal, my fears were realized when his next course of action was to prescribe Sarafem (another form of Prozac) for my symptoms. I took it for two weeks, but wasn't happy taking it. I felt there had to be other options I could try before resorting to medication.
What was your initial and then longer-term reaction to the diagnosi
At first, I was not sure the diagnosis was correct, since we had not discussed other aspects of my medical history. However, after doing my own research, I eventually agreed that the diagnosis of PMS seemed accurate. I felt great relief in finding some kind of name for this emotional and physical roller coaster, and realizing I had choices.
How do you manage your condition?
At this time I take good care of myself and carefully monitor how I'm feeling and what affects me at different times. I read about PMS and some of the herbs that help. I educate myself about new treatments and foods that help diminish some of the symptoms. While not all of my symptoms are alleviated, I feel they are more managed and under control. Things that used to send me spinning, now cause me to just sit down and work them out. I feel happier, and my desire to enjoy past hobbies has returned. I don't feel I will ever necessarily be free from my PMS until after menopause, but I don't have to let it control me and take away who I really want to be.
Have you made any lifestyle or dietary changes in response to your condition?
I walk every morning for at least 30 minutes in the fresh air and bright sunshine. I have cut out almost all caffeine and many, but not all, sugars. I want to manage my eating habits but not be a slave to them. (Every gal has to have a piece of cheesecake once in a while.) I am good about grabbing a handful of crispy spinach instead of crunchy chips and try to munch on a carrot over a candy bar. I've learned to love my herbal teas, which I choose for their relaxing and soothing ingredients. I take a good multi-vitamin every day, and have incorporated some new foods and ingredients for overall health, such as milled flax seed.
I also try to find time to relax and do things that I enjoy doing. You'd be surprised how therapeutic a milk and herbal bath with a glowing candle can be. Perhaps someday I may need to look at the prospects of medication, but this would be a last resort.
Did you seek any type of emotional support?
I did seek emotional support cautiously and carefully. I didn't like to admit that I was struggling with PMS because it was such a common social joke, and I didn't want anyone to think I couldn't handle myself emotionally. I was afraid of rejection and misunderstanding. I would ask general questions about PMS in a group of women, but wouldn't say that I needed the information for myself.
I also didn't really bring it up with my husband, even though we have a great relationship. Somehow, I didn't feel he would understand or even be able to help, simply because he isn't a woman. He is such a logical person that I felt sure he would think there was some logical explanation and solution to my problem. PMS simply doesn't work that way and is much more tricky and a master of disguise. I felt he would worry about me and would feel so helpless because he wouldn't know how to relate.
Did/does your condition have any impact on your family?
It was always important to me that PMS didn't get in the way with my relationship with my kids and husband. Of course, I was naive to think that they didn't notice. But I have taken steps to be honest with them, and overall, I don't think it affects them a whole lot.
I chose to be open with them after the diagnosis because I wanted their support. I wanted the kids to understand why mommy wasn't going to throw every junk food they grabbed into the grocery cart anymore. I also wanted to let them know that I was going to demand some alone time once in a while. I let them all know that I loved them and we could have great times together, but that sometimes, I was going to treat myself to quiet time. They have been great.
I think PMS has brought us closer. I talk more freely about how I'm feeling at a particular time and ask them to be more understanding with me. They feel more open about letting me know when I'm being harsh or just not acting myself. But it has its down sides too. My husband has had to be very understanding many times when I simply cannot seem to get the desire to be intimate. PMS can make you feel very selfish and self-centered at times.
What advice would you give to anyone living with your condition?
PMS is an uncomfortable ride that you are on, but it does not define who you really are. Things to keep in mind are:
Take care of yourself through nutrition and exercise! Paying attention to food and exercising regularly may help lower your medication dosage, or eliminate the need for medication altogether.
Do your own research and homework. Don't just rely on your doctor to suggest a plan of treatment without educating yourself on the choices he/she is offering you. Be sure you feel that all options have been explored, and work to find a solution that is as comfortable or drug-free as possible.
Sometimes medications may be necessary, but you have some work to do on your end, too. You cannot rely on just popping a pill in your mouth every day.
It's OK to feel emotional, to be angry, to be anxious. But, you don't have to drown in those feelings. You can share, you can talk, you can seek help, and you can gather information.
Find others who are going through what you are. Sometimes, just knowing that PMS affects so many other women and that you aren't going crazy is a big relief. Just sharing your feelings with someone relieves a lot of pressure. When you discover that another woman with PMS is experiencing some of your same symptoms, it gives you a feeling of camaraderie—that you are both in this fight together. Get out there and help someone else that is just as scared and confused as you were (and sometimes still are), and see how good it makes you feel.
Interviews were conducted in the past and may not reflect current standards and practices in medicine. Talk to your doctor to learn more about how this condition is diagnosed and managed today and what treatment approaches are right for you.
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Heartland Institute
Maureen Martin
Maureen Martin
Maureen Martin passed away on February 5, 2013. The Heartland Institute's page in tribute to her...
(read full bio)
Animal Rights Wrongs
Maureen Martin
February 06, 2013
Ten years ago the American Society for the Prevention of Cruelty to Animals (ASPCA) sued Ringling Bros.–Barnum & Bailey circus for alleged mistreatment of its elephants.
Jail Money
Maureen Martin
February 04, 2013
Lawsuits filed by inmates in Rikers Island, New York City's main jail – most of them frivolous – have cost the city more than $111 million over the past five years.
Maureen Martin
February 01, 2013
If you go to a baseball game, you assume the risk of getting struck by a baseball – but you don't assume the risk of getting hit with a hot dog.
No Kidding Her
Maureen Martin
January 28, 2013
An Ohio teacher is suing her school district for discrimination after they reassigned her from a high school to a junior high school and pressed her to resign.
Gold Finger
Maureen Martin
January 25, 2013
An upstate New York man "gave the finger" to a cop using a radar gun and now may get paid for it.
Transparent Fraud
Maureen Martin
January 23, 2013
A jury award in West Virginia will require two lawyers and a doctor to pay CSX Rail $429,240 for racketeering and fraud in the reading of x-rays in asbestos cases.
Beer Blast
Maureen Martin
January 21, 2013
A group of prison inmates in Idaho is suing major beer companies, alleging the brewers are responsible for their lives of crime.
Child Exploitation
Maureen Martin
January 18, 2013
It didn't take long for trial lawyers to begin trying to profit from the Newtown massacre.
The Candy Man Can't
Maureen Martin
January 15, 2013
A soda fountain in St. Paul may be fined $500 by city inspectors for selling candy cigarettes.
A Christmas Greeting
Maureen Martin
January 13, 2013
A Louisiana woman has the constitutional right to hang Christmas lights on her house in a pattern giving her neighbors the middle finger.
Attractive Nuisance
Maureen Martin
January 11, 2013
It was legal for a Fort Dodge dentist to fire his long-time female dental assistant because of his "irresistible attraction" to her, the Iowa Supreme Court ruled recently.
'A Bird-Brained Idea'
Maureen Martin
January 09, 2013
As if Chicago police didn't have enough to do.
High-Heeled Sneaker
Maureen Martin
January 07, 2013
It's not unusual for persons claiming workers' compensation to be caught faking their injuries, but a recent California case has an unusual twist.
Personal Irresponsibility
Maureen Martin
January 04, 2013
A Wisconsin man who can't pay almost $100,000 in overdue child support and interest for the nine children he fathered has been sentenced to probation and ordered not to have any more kids unt
Property Casualty
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December 28, 2012
Two years ago, the town of Harvey Cedars in New Jersey had a two-story sand dune constructed in front of 190 ocean-front homes to protect them from storms. The U.S.
Beer Battle
Maureen Martin
December 26, 2012
It's the real-world equivalent of Jarndyce v. Jarndyce, the fictional lawsuit Charles Dickens wrote about in Bleak House.
Gaming the System
Maureen Martin
December 20, 2012
A Buffalo Bills fan is suing the football team, alleging it sent him too many text messages.
Skin Deep
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December 16, 2012
A Chinese man sued his wife for divorce, alleging she tricked him into marrying her by disguising her ugliness with plastic surgery.
Man's Inhumanity to Maniac
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December 14, 2012
A Norwegian man imprisoned for the massacre of 77 people last year has hired a lawyer to complain his prison conditions are "inhumane."
Men Not Working
Maureen Martin
December 13, 2012
An Ohio community college forced a construction crew to stop working until its "Men Working" signs were removed because they violated the college's diversity requirements.
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text:
! Oregon Republican Party Staffer Attacks Cameraman, State Chair Allen Alley Runs From Questions
Submitted by MichaelStrick9 on Sat, 07/14/2012 - 23:35http://www.youtube.com/watch?v=jbU-F510PhY (Sorry, I can't figure out how to embed video on here)
The Oregon Republican Party held it's organizational meeting for the RNC delegates on July 14th, 2012.
Before the meeting started, LAL finds Allen Alley and Greg Leo out back bringing things inside the building.
Mr. Greg Leo attempts to intercept me on my way to ask Mr. Allen Alley a couple of questions. Mr. Alley declines to comment or answer the tough questions regarding his handing Oregon to Obama (by ostracizing the Ron Paul supporters, ensuring that they will not be supporting Romney) and his past donations to Democrat campaigns (source: http://www.opensecrets.org/indivs/search.php?name=alley%2C+a... ).
Mr. Leo then punches me, and hits my camera in the process.
All this while security guards from Guardian Event Security, hired by Leo and Alley, stand by and do nothing. Instead of these security guards doing their job, Mr. Leo and a female feel the need to move in front of Alley to "protect" him from the camera. Security also fails to act when Mr. Leo assaults me. One of the security guards just holds a door the whole time.
Why does the ORP resort to violence? Why does the ORP refuse to answer the tough questions?
Please also see http://www.youtube.com/watch?v=83lz9Lrn8IM for the run down of what happened at the district convention, where the state party heads stalled in order to shut down the meetings before the alternate delegates could be elected.
- Login to post comments
This is BS!
I'm TIRED of "people" (for the sake of being respectful) getting away with this! I sincerely hope you are pursuing legal action and that you don't let this "slide". State after state, they have gotten away with too much already and they will CONTINUE to do so until there is an example set and someone pays the consequences. This would have made headline news if it had been a "rowdy" Paul supporter.
- Login to post comments
Same "security guard"
they had in Eugene at their illegally called and held meeting of June 30th where there were 2 guards on duty. How interesting the same guard is on duty for the same 'customer' over 100 miles away. Excellent customer service for that guard company to send the same guards for multiple security requests so far apart. They must care about their customers so much they forgot to renew their license.
- Login to post comments
There were actually 3 guards
There were actually 3 guards also at the June 30 meeting in Eugene. At least two of the guards hired yesterday were also hired for the June 30 meeting.
- Login to post comments
Cant wait to see the ORGOP lose all these big wigs out of the party executive positions come November. Mit Romney will lose Oregon by a landslide. I'll be he wont even get more than 35% of the vote.
- Login to post comments
I'm Just Amazed !
That party loyalty is more important than the U.S. Constitution !
Everybody in the country should know by now, that RON PAUL is the only republican or democratic Presidential candidate that will obey the strict guidelines written in the U.S. Constitution, that he took an oath to defend, when he entered the USAF in the 1960's, and the 12 times he was sworn into office as a U.S. Congressman.
Mr. Romney, a well known "Chicken Hawk" will not defend the Constitution, against ALL enemies foreign and DOMESTIC. He does not have any federal government experience, at this time guaranteeing another 4 years for Mr. Obama.
- Login to post comments
Party "Loyalty" means BIG-BIG Ponzi Schemes and the
Raiding of the US Treasury. You see, following the Constitution and actually abiding by the laws doesn't make for good business opportunities; no money to be made; con artists and thieves can't follow the rules within that document and make a decent living.
Now, on the other hand: Trampling the constitution; circumventing it; sidestepping it, and basically wiping one's A$$ with it, with the help of the courts, makes BIG MONEY!
You know, kind of like how criminals don't care about gun laws. There's no money to be made "abiding by the law", and there you have it.
- Login to post comments
I hope you go TMZ on Allen Alley
Dont take the spotlight off him... Don't let the corruption be swept under the rug. He needs to be exposed.
- Login to post comments
An Answer To The Whys:
- Login to post comments
Tweeted. So far you have 13 views.
I think you are right. Obama will win if Crooked Lying Willard the Pig is the nominee.
- Login to post comments
Hey now!
Let's not resort to name calling!
I know some pigs that would take offense to that... :-)
In Liberty!
America Rising.
The Constitution Stands.
"That the pen is mightier than the sword would be proven false; if I should take my sword and cut off the hand that holds the pen" - American Nomad
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text:
In the Store
In the Store
featured articles
industry headlines
Net Element, Inc., a technology-driven group specializing in mobile payments and value-added transactional services in emerging countries and in th
Samsung Electronics Co, Ltd.
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One of the first in the franchise system to receive the remodel, the Chronic Tacos location in Saugus, California, will open the doors to a newly r
Sani Professional, the food safety division of Professional Disposables International (PDI), and the Sani Professional Food Safety Advisory Council
Firehouse Subs, a fast casual with more than 860 locations, announced a nationwide rollout of Apple Pay.
The Howard Company Inc. celebrates their 65th anniversary in the display and menu board industry starting this month.
Guthrie's is poised for significant growth this year as they celebrate the company's 50th anniversary in July.


text:
byCRN Staff on
2013 Virtualization 50
Get a roundup of CRN's virtualization coverage right to your inbox with the CRN Virtualization newsletter.
Big Switch Networks
Top Executive: Guido Appenzeller, Co-Founder, CEO
Big Switch has become the top dog of SDN startups since VMware bought Nicira. It uses the OpenFlow switching and communications protocol, which handles packet routing on a software layer separate from the network's physical infrastructure. The company recently launched Switch Light, an open-source thin switching platform.
As solution providers position themselves for growth, the pressure is on vendors and distributors to meet their partners' needs. Here CRN presents the 2015 Channel Chiefs, our annual look at the executives responsible for running channels at today's IT vendors.
Here are 10 recent searches by CRN visitors.
Cloud 100


text:
Town Square
First Person: A conversation with Ben Lee
Original post made on Jul 30, 2012
Read the full story here Web Link posted Sunday, July 29, 2012, 10:02 AM
Comments (1)
a resident of Downtown North
on Jul 30, 2012 at 3:41 pm
Officer Ben Lee is a credit to the Palo Alto Police Dept. - both for his service as a patrol officer and his willingness to spend hours teaching others the game of badminton.
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text:
Samsung Galaxy Nexus Ice Cream Sandwich OS Smartphone With 1.2 GHz Processor – Review and Specs
The Samsung Galaxy Nexus is new Smartphone by Samsung which is expecting to launch next week. The Samsung Galaxy Nexus is high-end Smartphone slick and slim design. This Android Smartphone has a 4.56 Super AMOLED HD Touchscreen Display with 16 777 216 Colors & 720 X 1280 Pixels resolution. It is also comes with Multi […] Continue reading →


text:
by Chris Brauns
Language: English
Publisher:Moody Publishers
Mardel Price $7.49
Ship To:
At any given time there are thousands of churches seeking a lead pastor. What should local congregations focus on to find a new shepherd? Chris Brauns believes to find a great preacher the search must focus on God's Word.
This book is a must have resource for search committees and church leaders addressing the needs of churches in the transition of pastoral leadership. It assists by approaching their responsibilities in a biblical way and providing critical help in key practical matters. From the initial formation of a search committee to the final terms of agreement with the new pastor, Brauns shows you how to "major on the majors" and away from subjective approaches of evaluating candidates and their sermons.


text:
Year: | 11 |
Hometown/School: | Boston, Mass. |
Andy Bernard got his squash start at the age of 4, taking lessons at Brooklyn's Heights Casino. After a 12 year hiatus, he picked up the sport once again, this time for keeps, while attending Milton Academy. He also plays ultimate frisbee for Bowdoin's Stoned Clown. Andy is considering an Economics major and a Film Studies minor, and some of his favorite musical artists are Madlib, Barrington Levy, and De La Soul. |


text:
咨询电话 Tel.: (86-0755) 8238 9912 (86-0755) 8238 9913
咨询电邮 E-mail: firstname.lastname@example.com
Kinetic Key Co. Ltd. (KKCL) and Shenzhen Wen Jian Da Co. Ltd. (SWJDCL) have been providing professional services for ocean going vessels in Hong Kong and Shenzhen, China (PRC) since 1988 and 2004. Services provided include but not limited to Underwater Survey, Video Inspection, Underwater Repairs, Problem Solving and Services of Marine Diesel Engines, Turbo Charges and Speed Control Governors.
Mr. Kin-Kwong Li, the Founder of our Group, is a British, Chinese and Hong Kong Registered Marine Engineer and Licensed Commercial Diving Specialist since 1982 and 1990 respectively. Mr. Li has involved in variety of ship building, marine/civil engineering installation and maintenance projects both above and under water for more than 30 years. With his sound experiences in ship building, marine engineering and commercial diving, Mr. Li has been inviting as Expert Witness at the High Courts in Hong Kong to provide expert opinions and advises on marine and commercial diving accidents since 1995.
Professional Qualifications of Mr. Kin-Kwong Li:
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For inquiry, please contact Mr. Li on Tel.: (86-0755) 8238 9912, 8238 9913, Fax.: (86-0755) 8238 9931 or E-mail email@example.com.
友情连接 Business Partners
[寰宇专业潜水集团] [香港寰宇潜水会-潜点相片集] [Shenzhen Scuba World Centre and Hong Kong Scuba World Club] [Scuba World Club - Dive Sites Photo Gallery]


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[April 29, 2014]
Fujitsu Strengthens Server Customization Business for VAR, OEM Markets
(ENP Newswire Via Acquire Media NewsEdge) ENP Newswire - 29 April 2014 Release date- 25042014 - Tokyo - Fujitsu today announced that it is taking steps to strengthen its server customization business for VAR and OEM, two markets anticipated to see future growth.
The company will begin offering a menu of 200 customization options for FUJITSU Server PRIMERGY x86 servers, and has prepared models based on individual patterns of customer needs.
This menu will make it simple for ICT vendors to pick the customization options that meet their needs, enabling them to quickly and inexpensively develop their business, rather than designing, developing, and manufacturing their own products.
Background Fujitsu has built a global VAR and OEM business with servers such as mainframes, as well as peripheral and communications equipment. Today, its products are used in equipment for facilities and testing in the manufacturing industry, distribution industry, and others.
In May of 2011, to elevate its position in the VAR and OEM markets, Fujitsu established the Embedded System & OEM Business Division, offering customizable products that meet the needs of its customers in these markets. Since then, the company has established a solid track record of performance in this field. Fujitsu is now building on that success and the knowhow it has accumulated to date by organizing its customization options into a menu that enables easy decision making for customers.
Overview of Customizations for VAR and OEM Customers 1. Menu of 200 customization options to meet different needs There are 200 options for customization available for PRIMERGY x86 servers, including logo changes on the server chassis, optional equipment, and bundled software, as well as varied configurations of bundled hardware. These can accommodate a wide range of needs, including for external appearance and operating environments, and for changes to the display of local certifications on products provided to overseas markets.
2. Selection of options for easy customization using models based on individual patterns Fujitsu has created three customization patterns - rebranding, appliances, and kitting - which are among the most frequently requested sets of customization options from the menu of 200. This enables customers to select a set of customization options as a group, depending on the objective, and have them quickly reflected in the product.
Pricing All customization pricing is by quotation.
Future Plans Fujitsu plans to meet customer needs by extending this ability to customize to other products. The company also plans to offer support services, including engineering services in which Fujitsu acts as the customer's agent for performance testing, and technical helpdesk support for troubleshooting.
Glossary and Notes VAR Value-added reseller. A business model in which a company adds value to its products by selling them in combination with a customer's hardware, software, and services.
OEM Original equipment manufacturer. A business model in which a customer sells the company's products under the customer's own brand.
About Fujitsu Fujitsu is the leading Japanese information and communication technology (ICT) company offering a full range of technology products, solutions and services. Approximately 170,000 Fujitsu people support customers in more than 100 countries. We use our experience and the power of ICT to shape the future of society with our customers. Fujitsu Limited (TSE: 6702) reported consolidated revenues of 4.4 trillion yen (US$47 billion) for the fiscal year ended March 31, 2013.
Press Contact: Fujitsu Limited Shiodome City Center 1-5-2 Higashi-Shimbashi Minato-ku, Tokyo Japan 105-7123 Tel: +81 (0) 3-6252-2174 Fax: +81 (0) 3-6252-2783 (c) 2014 Electronic News Publishing -
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As the adopotion of cloud computing continues to increase, businesses are finding, while they understand the potential benefits, they need help understanding the security and compliance ramifications of moving data into cloud data centers.
Managing Your Data and Apps in Multi-Cloud Environments: Right Scale
Businesses have reached beyond education and are starting to make signifcant cloud computing deployments, which means they need an awareness of public and private resources, which to deploy in what instances, and how to manage and maintain applications across both domains.
How Cloud Providers Can Drive Revenues for Tenants and Themselves: Interxion
In order to enable customers to create new revenue streams from their content and applications, cloud providers can provide test environments to allow businesses to more efficiently develop and test new applications.
Enabling Cross-border Data Center Connectivity: Interxion
One of the challenges for multinational enterprises is establishing connectivity between infrastructure located on different continents. The Transatlantic Data Center Alliance helps overcome many of these challenges, including regulatory and compliance needs.
infoTECH Whitepapers
SAP Enterprise Mobility: Bringing a Cohesive Approach to a Complex Market
What is Your Mobile Content Policy? A Checklist for Content Risk Mitigation
SANS Whitepaper: Mobile Content and Document Management Best Practices and Decision Checklist
IBM SmartCloud Social Collaboration for Government
IBM SmartCloud Solutions: Software as a Service
IBM SmartCloud for Social Business Mobility
IBM SmartCloud Engage Security
The Forrester Wave: Cloud Strategies Of Online Collaboration Software Vendors, Q3 2012
Social Business in the Cloud
The Social Business: Advent of a new age
What is Information Tehnology
What is Information Technology?
The History of Information Technology
Today's Most Desired Information Technology Skills
Information Technology Careers
Ten Information Technology Companies of 2011


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I can't remember the last time we saw a 26 year old Bourbon at K&L - even when the good old days of mature Bourbon were in full swing. To find an American whiskey with this level of maturity and for this price is shocking, especially in this bare market. The ethereal Old Blowhard is almost ghostly in its elegance. It's not rich, powerful, or in-your-face. The Blowhard is soft, delicate, and simply graceful in its profile - the wood flavors are haunting, rather than blunt. I've never tasted anything like this whiskey before, and I don't know whether I will again. This will be one of the most coveted bottles we sell this year.(David Driscoll, K&L Spirits Buyer)
Below is a listing of the wine review scores we frequently reference in our notes. While these sources remain an excellent source of information, we always recommend that you trust your own palate. Scores in these publications often represent the personal taste of an individual critic, which may not always coincide with your own. We have a huge team of excellent wine professionals that can match wines you've had in the past with new arrivals that meet your flavor profile.
The item you have chosen is not in stock in our retail stores or within our main warehouse.
Jefferson's Ocean Voyage #4 Aged at Sea Very Small Batch Bourbon 750ml $82.99
Sazerac 90-Proof Straight Rye Whiskey 750ml (3 bottle limit) $29.99
Blanton's Original Single Barrel Bourbon 750ml (oversized bottle, ships as 1.5L) $46.99
Rittenhouse Rye 100 Proof, Bottled in Bond 750ml $23.99
Bulleit Bourbon Frontier Whiskey 750ml $21.99


text: Topics Investigations Email Comment Dallas chief: Video confirms police firing was justified Copy and paste the code below to embed this video. Close Dallas Police Chief David Brown spoke out for the first time about his decision to release dash cam video of a controversial police shooting. Tags Officer-Involved Shootings Join the discussion PoliceOne comments can only be accessed by verified law enforcement professionals. Please sign in or register to view or write your own comments below. Sign In Register


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Fling - World's Best Personals For Adults
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about my flingYou want to spoil me like the princess i am. It isn't always about money. its about the thought you put into it. You enjoy going out, but can also chill at home on the couch with a good movie. |


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- Your file is being downloaded. It will remain available for download from the "My Files" section of your member area for 72 hours.
#13420992 -
abstract bird
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Author | AmidSee portfolio |
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abstract abstraction artistic backdrop background bird blend blue color cyber design desktop digital dove dream dynamic effect flow fly form future futuristic graphic gull happiness illustration layer light line messanger motion net pattern piece presentation print publicity sea shape shiny space techno template theme transition wallpaper wave web white wing
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LKQ Pick Your Part In located in East Baltimore can help you save hundreds of dollars in used auto parts. This LKQ location used to be Crazy Rays Auto Parts and was recently acquired by LKQ. When you buy parts from Pick Your Part you know that your parts are backed up by a 30 day warranty and the option to go to any of their hundreds of junk yards around the country and get a replacement from them as long as you have your receipt.
LKQ Pick Your Part Baltimore Counts with hundreds of vehicles ready to be dismantled and pull parts from, the process is simple, bring your own tools since they will not lend you any, if the part is heavy of too big to carry on your own then bring some help, you have to pay an entry fee to get into the yard, once you are in all the cars are mounted for easy picking access, pull the part you need, go to the cashier, pay and you are done.
LKQ Pick Your Part Baltimore has a daily selection of vehicles entering the yard, so if you walk in and you can't find the car
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purple greeting cards, yellow greeting cards, cartoon greeting cards, cats greeting cards, canoe greeting cards, creek greeting cards, paddle greeting cards, vacation greeting cards, river greeting cards, pen greeting cards, ink greeting cards
TisArt Our Mission is to make you LOL. My name is "TisArt" aka Peadar Sheerin. I am descended from a tribe of Celts who ventured out upon the wild North Atlantic Ocean in currachs (native canoes). TIS is based on our Siamese kitten Twiggy who ended as a lovely sleepy old lady. I studied Japanese art at Trinity College Dublin, I am also a carver of wood. Both these skills influence my art. Keep it simple. The Zen painters of old expected to complete a 'work of art' in the space of one breath. I tried and failed miserably, puff , puff.
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
If you've hesitated to purchase artwork online in the past, why not give us a try? You have nothing to lose!
We take great pride in the fact that artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
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Nominated For a SEMMY Award
The SEMMYs, an annual online award event in the SEO industry, nominates posts for recognition on a variety of topics. We're proud to announce that this year one of our posts has been nominated as a SEMMY finalist in the category of reputation management. Our readers may remember reading the extensive and thorough post "Be Proactive With Your Reputation Management" (posted September 18th) now nominated for the award. We discuss the importance of being proactive with your online reputation management, and give you 16 opportunities to dominate the search engine rankings for your business name.
As a SEMMY finalist our readers, friends, family, and connections are able to vote for our post to win the prestigious award. Voting closes this Friday, and we'd be thrilled if you took a few moments to vote: here. Feel free to pass on the word and help us win by telling your friends on Twitter, Facebook, or via e-mail. We've made it easy, just copy and paste: VM made the 2010 SEMMY Awards Finalist list in category: Reputation Management!!! http://bit.ly/SEMMYFinalist Vote 2day!
Tags: reputation management, search engine rankings, SEMMYs, SEO, vertical measures
About Kaila Strong
As Senior Director of SEO Services, Kaila oversees both the SEO department and our Internet Marketing Strategists. She works with our expert team to uncover SEO strategies, develop link building campaigns, conduct competitive analysis, review Google penalties, execute backlink analysis and train peers on SEO fundamentals. +Kaila Strong
3 Comments
Todd Jan 29, 2010
Congrats on the nomination, its recognition well deserved.
Awards and Certificates Feb 06, 2010
I never heard of SEMMy but I am glad to hear that awards on seo also exist.
reeya Feb 07, 2010
same Congrats on the nomination, its recognition well deserved.very nice work.
Recent Posts
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Feb 27, 2015
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Feb 24, 2015
- The Weekly Measure: Buyer Personas, Twitter and Google Partnership & Shareworthy Content Creation
Feb 20, 2015
- Twitter Partners with Google: What You Need to Know
Feb 19, 2015


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San Francisco leads 3-0 (as of 7/22)
Game 1: Thursday, July 20 | ||
San Diego | 3 | Final |
San Francisco | 9 | |
Recap »Boxscore » |
Game 2: Friday, July 21 | ||
San Diego | 2 | Final |
San Francisco | 8 | |
Recap »Boxscore » |
Game 3: Saturday, July 22 | ||
San Diego | 3 | Final |
San Francisco | 4 | |
Recap »Boxscore » |
Game 4: Sunday, July 23 | ||
San Diego | 6 | Final in 12 |
San Francisco | 5 | |
Recap »Boxscore » |
9:05 PM ET, July 22, 2006
AT&T Park, San Francisco, California
SAN FRANCISCO (AP) -- Felipe Alou had just finished telling the story of his new five liter bottle of red wine, a congratulatory gift from his employers for his 1,000th managerial victory, when someone reminded him the Giants now lead the NL West.
"Oh man," the San Francisco skipper said with a smile. "Oh, yeah, it means something. Just a week ago, seven days ago, we were supposed to be that bad. I don't really worry about it. I left all my worries behind me now."Jason Schmidt won for the first time in more than six weeks, and the Giants took over first place in the division with a 4-3 victory over the San Diego Padres on Saturday night.Eliezer Alfonzo hit a two-run single, doubled and scored twice, and Randy Winn added a sacrifice fly as San Francisco moved a half-game ahead of the Padres and into the division lead for the first time since April 26 with their season-best fifth straight win.The Giants' winning streak is their longest since also getting five straight victories from Sept. 16-21.Schmidt (7-6) pitched six solid innings to end a seven-start winless stretch and three-game losing streak on a night when the temperature was 85 degrees at first pitch on an unusually warm July day in the Bay Area."This has been a big series for us," Schmidt said. "Winning three out of four, you couldn't have asked for anything better than that."Shea Hillenbrand singled and scored a run in his Giants debut a night after being acquired from Toronto along with right-hander Vinnie Chulk in a trade that sent right-hander Jeremy Accardo to the Blue Jays.Barry Bonds was back in the lineup after leaving Friday night's 8-2 win following his leadoff single in the third inning. He had been plunked in the left knee by Jake Peavy in the first.The slugger went 1-for-3 with a single and an intentional walk, his 81st walk and 32nd intentional free pass. His left knee held up for the entire game."It's fine," Bonds said. "I can't complain."Schmidt, the Giants' lone All-Star representative, won for the first time since beating the Florida Marlins and matching a franchise record with his 16-strikeout performance June 6. The right-hander also snapped a three-game losing streak to San Diego, beating the Padres for the first time in six starts since a 7-5 win on Sept. 28, 2004. He allowed six hits and three runs, struck out five and walked five.Armando Benitez converted his seventh straight save and 13th in 17 chances overall.Schmidt was boosted by a fine day of defense by the Giants, including Pedro Feliz's nifty double play in which he tagged Adrian Gonzalez on the way to third, then threw to first to get Khalil Greene. Alfonzo made a great play on a foul popup by Woody Williams in which the catcher reached around the backstop to catch the ball."Defensively, guys have played outstanding," Schmidt said. "I've been holding my cool pretty well. If I would have given it up tonight, I would probably have beat my head against the wall."Hillenbrand singled to left in his first at-bat leading off the second, three days after being designated for assignment by the Blue Jays following a clash with management. He started at first and batted sixth, getting a loud ovation when lineups were introduced before the game and again when he singled.Mike Cameron, 1-for-9 in the series coming in, hit a solo home run in the fifth for the Padres, a shot to left-center for his 13th of the year. Gonzalez followed with a single to extend his hitting streak to 13 games.San Diego lost its fourth straight overall and fifth in a row in the season series with San Francisco after winning five of the first six meetings."It's going to be a tight race," Padres manager Bruce Bochy said. "We've got to stop what we're in right now."Williams (4-2) had his three-game winning streak snapped, a stretch that began with his victory in San Francisco on May 2. He had a no-decision against the Giants on July 1 in his first outing back from the disabled list after missing a month and a half with a strained left calf."I've thrown well the last two games," Williams said. "It seems like everything snowballs for us, either way. Our defense has been very good. For this game to end up like it did is kind of strange. Since the All-Star break, we haven't played like we're capable. We're confident, but we haven't been consistent."San Francisco's Moises Alou hit his second single of the game leading off the fifth but strained his left hamstring running out the hit and came out of the game. Steve Finley entered to pinch run and came in to play center field, with Winn moving to Alou's spot in right.Alou was to be re-evaluated Sunday and his manager father expected him to miss a couple of games.Game notes
The Padres acquired RHP Scott Williamson from the Chicago Cubs in exchange for Class-A pitchers Fabian Jimenez and Joel Santo. ... Cameron stole his 15th and 16th bases of the season in the first. ... San Diego OF Brian Giles missed his second straight game with a tight right hamstring. ... The Giants sold out for the 15th time, going over the two million mark. ... Schmidt had his 1,000th strikeout as a Giant.
Copyright by STATS LLC and The Associated Press
Regular Season Series
San Francisco leads 12-7 (as of Sat 7/22) | ||
Mon 4/3 | @SD 6, SF 1 | Recap |
Tue 4/4 | Postponed/Delayed | Information |
Wed 4/5 | SF 3, @SD 1 | Recap |
Mon 5/1 | SD 10, @SF 4 | Recap |
Tue 5/2 | SD 5, @SF 3 | Recap |
Fri 6/30 | @SD 6, SF 5 | Recap |
Sat 7/1 | @SD 7, SF 4 | Recap |
Sat 7/1 | SF 4, @SD 1 | |
Sun 7/2 | SF 6, @SD 2 | Recap |
Thu 7/20 | @SF 9, SD 3 | Recap |
Fri 7/21 | @SF 8, SD 2 | Recap |
» Sat 7/22 | @SF 4, SD 3 | Box Score |
Sun 7/23 | SD 6, @SF 5 | Recap |
Mon 8/14 | SF 1, @SD 0 | Recap |
Tue 8/15 | SF 3, @SD 2 | Recap |
Wed 8/16 | SF 7, @SD 5 | Recap |
Thu 8/17 | SF 8, @SD 4 | Recap |
Fri 9/8 | @SF 4, SD 0 | Recap |
Sat 9/9 | @SF 5, SD 4 | Recap |
Sun 9/10 | SD 10, @SF 2 | Recap |
Complete Schedule: Padres | Giants |
Scoring Summary
1st | G Blum walked, M Cameron scored, A Gonzalez to third, R Bowen to second. | 1 | 0 | |
2nd | E Alfonzo singled to center, S Hillenbrand and P Feliz scored. | 1 | 2 | |
2nd | E Alfonzo scored on W Williams' wild pitch. | 1 | 3 | |
4th | T Sledge singled to left, K Greene scored. | 2 | 3 | |
4th | R Winn hit sacrifice fly to center, E Alfonzo scored. | 2 | 4 | |
5th | M Cameron homered to left. | 3 | 4 | |
View complete Play-By-Play |
Game Information
Stadium | AT&T Park, San Francisco, CA |
Attendance | 42,955 (102.5% full) - % is based on regular season capacity |
Game Time | 2:48 |
Weather | 85 degrees, clear |
Wind | 17 mph |
Umpires | Home Plate - Marvin Hudson, First Base - Ed Montague, Second Base - Jerry Layne, Third Base - Mark Wegner |


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A fabulous vintage pietra dura (hard stone) mosaic pin.
Set in an open back gold frame, the floral bouquet has a large pink cabbage rose in the center with olive green foliage.
Surrounding flowers include tiny blue forget-me-nots, a white daisy and white lilies and buds.
Graceful lines, lovely gradation of color on the leaves.
Set in a simple 9k gold bezel, unmarked but tested with acid.
The side is engraved with a name- H.P. Cousens.
Very well made and in excellent condition, no damage, minimal wear, secure long tube catch.
Measures 2&3/16" by 5/8".
A beautiful example of Italian pietra dura mosaic.
Please view the large photos for best detail.
I offer layaway on all items purchased for full retail price. In general my layaway terms are 1/3 down and 1/3 in 30 days and the last 1/3 in 60 days. I am flexible so if you are interested please ask me and we can work out a payment plan that suits you. Items ship when payment is complete and items purchased on layaway are eligible for exchange only.
Item ID: 01ppietraduramosaic
Layaway plans available
Welcome to BeJewelled ~ fine antique & vintage jewelry, costume & designer jewelry, unique antiques & quality collectibles
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Issue 6 • Date Nov/Dec 1995
Filter Results
Computer-aided selection and verification of circuit breakers
Publication Year: 1995 , Page(s): 26 - 32
Cited by: Papers (2)Procedures governing medium- and high-voltage breaker application, although conceptually tractable, tend to be repetitive for large systems. Hand calculations can become quite laborious when assessing safety margins of installed switchgear on systems that have experienced sudden growth. This article describes how a computer can be used as an efficient tool to address these concerns. The discussion focuses on how the computer can be used to interface the short circuit study results to the breaker modules, on how breaker adequacy evaluation can be computerized, and finally how these calculations can be extended to yield automated breaker selection according to user-defined criteria and breaker rating structures. The discussion is confined to the North American breaker application procedures and rating structures as tabulated in the ANSI Standards, and addresses only short circuit current interrupting requirements View full abstract»
Modeling of electrostatic-based pesticide spray systems
Publication Year: 1995 , Page(s): 33 - 41A microscopic model for the electrostatic spraying system is presented to investigate the effect of the voltage applied to the induction nozzle on the droplet's charge, mobility, and charge-to-mass ratio. The variation of these parameters along the jet was also included. The model also lays particular emphasis on the effect of the applied voltage on the spray current and the charge density at the nozzle. A macroscopic model for the electrostatic spraying system is also presented. The objective of the model was to study the spatial distribution of the droplet charge density, transit time, and trajectory in the region between the nozzle and the target in terms of the flow velocity of the spray and the space-charge-produced electric field. On the macroscopic scale, both the droplet charge density and the spray current increase with the voltage applied to the charging electrode. With the decrease of the spray flow velocity, the space-charge-produced electric field becomes dominant and tends to: contract the droplet trajectories toward the axis of the spray system, and hence enhance the droplet deposition efficiency; and decrease the charge density at the target with the possibility of minimizing back-ionization. On the microscopic scale, induction charging eliminates the ion current from the current to the target and the associated back-ionization. The calculated droplet charge and charge-to-mass ratio which increase with the voltage applied to the charging electrode, agreed with the values reported previously View full abstract»
Contactless charging and communication for electric vehicles
Publication Year: 1995 , Page(s): 4 - 11
Cited by: Papers (15) | Patents (3)Charging batteries in electric vehicles needs to cover several aspects including electrical safety, the weight of an onboard charger, different types of chargers needed by different types of batteries, low line disturbance with high efficiency, and the influence of the charging process on the lifetime of the battery. Another important problem is the communication between the vehicle and the outside world during the charging process. This article describes a system combining energy transfer and signal transmission in one unit, which is able to solve all of the above-mentioned problems. Minimal power electronic components are installed in the vehicle. The system uses contactless energy transmission employing an inductive high-frequency coupler. The charging process is monitored and controlled by an onboard charge meter, which can communicate with the converter outside the vehicle via the signal transmission included in the inductive coupler. A laboratory setup able to transfer up to 5 kW was built to demonstrate the performance of the system. The efficiency of the overall system, including all filters, converters, and rectifiers, is at a power level of 5 kW better than 92%. The used gelled lead acid battery, 35 Ah and 288 V, was made from 24 battery modules View full abstract»
Control batteries: power system life savers
Publication Year: 1995 , Page(s): 18 - 25If protective devices and relays represent the ≫OPEN "nerves" of a medium- or high-voltage electric power system, the DC control battery distribution system represents the system's "bloodstream." The battery distribution system delivers energy the battery provides to the control circuits of AC circuit breakers and other electrically operated interrupting equipment (the "muscle" of the electric power system), allowing operation. The battery is the DC power distribution system's "heart." Reliable control battery systems assure proper functioning of well designed, installed, and maintained power systems. Battery system failure jeopardizes a power system by eliminating the DC control power source for AC system circuit breakers and protective devices. Failure to protect DC system components also could result in disastrous consequences for the battery system itself. The author discusses battery faults, battery protection, and battery maintenance. Battery charger faults and protection are also briefly mentioned, as are load protection, and DC system protection View full abstract»
UPS applications: a mill perspective
Publication Year: 1995 , Page(s): 12 - 17
Cited by: Papers (3)This article results from the experience of installing a number of uninterruptible power supply (UPS) systems for various projects. It attempts to describe typical applications in a pulp and paper mill, determines how to evaluate whether a UPS system should be used, and suggests some alternative approaches to the problem. There are several types of UPS configurations available. Although rotating types are extensively used, the static type is more prevalent and is the basis for most of the discussion. Many applications have potential problems with power quality and availability. Factors are listed that will help determine whether a UPS system should be installed. Typical applications in pulp and paper mills are listed and discussed. Problems from some actual installations are described and alternative approaches are examined. Power quality and availability is a design consideration that requires careful attention to achieve the desired result. It will be more important in the future as utility power systems become less reliable View full abstract»
Aims & Scope
IEEE Industry Applications Magazine reports on the development and application of electrical systems, apparatus, devices, and controls to the processes and equipment of industry and commerce; the promotion of safe, reliable, and economic installations; the encouragement of energy conservation; and the creation of voluntary engineering standards and recommended practices.
Meet Our Editors
H. Landis "Lanny" Floyd


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Bravo School Of Art: Pet Or Wildlife Portrait
- When Tuesday, March 19, 2013 at 6 p.m.
- Where Bravo School of Art, San Diego
- Age limit All ages
- Categories Animals, Arts, Lectures & Classes, Painting
- Cost $57 - $63
Above: Promotional image of a Pet Or Wildlife Portrait made at Bravo School of Art.
Immortalize your pet or favorite animal in your own creative style. Lay out the basic animal's shapes and build with shadows and highlights to render a beautiful and unique painting. This workshop is ideal for beginners and will introduce the structural basics of animal portraiture.
Please bring an image of your favorite animal or pet that you would like to recreate. If you are painting a pet portrait, please bring 3 - 4 images of your pet to capture its personality and unique markings. Red, yellow, blue, white and black acrylic paint, brushes, mixing plate and a 16" x 20" canvas will be provided.
Date: Tuesday, March 19th from 6 - 9pm Register Today!
Location: Bravo School of Art, 2690 Historic Decatur Rd Studio 206: Google Map.


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Patient Reviews
Patient Reviews ? Write a Review
Overall Rating:
Total Ratings12 |
Total Reviews5 |
Resourceful, articulate doctor who is concerned about me as a patient and my long term health care.
Overall, Dr. M. was an adequate PC Dr. I only had him for a short while, and his office and demeanor were acceptable enough. I wouldn't call him outstanding, I wouldn't call him terrible. One thing that really annoyed me, though, was that he had referred me to have a Pulmonary Function test done, and instead of just calling me with the results, he made me schedule an appointment, just for him to tell me everything was fine. Of course, this is done to bill the Insurance Company, and, of course, it costs me a co-pay. What a waste. Sad when Doctor's act in this fashion.
This office is terrible. I was a patient by default he took over my old doctors practice. I have been to appointments first thing in the morning and found myself waiting in excess of a half hour. I have gone in with bloody stool and been told not to worry inspire of a history of colon cancer in my family. I have made spots with specialists and put in the referral request a month prior to the appt to have them never sent. Further I had one where I was called the day before an appt and was told they would not refer to him despite me having a history with this particular Dr. When I finally left not only did not all of my records make it but what did come came with a bunch of the records of another patient. When I informed the office they were attitudy to me like it was my fault. All in all this office is very poorly run and extremely unprofessional. If you need him for something don't hold your breath for a call.
Very good internal medicine doc.. Spends time with his patients and listens which is very important in getting an accurate diagnosis.
I fully rely on his opinions and he refers me to specialists immediately when needed.


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Searched for: "usb av antivirus free windows"
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About 4 results for "usb av antivirus free windows"
Droidpak: A sneak attack on Android devices via PC malware
New Android banking malware leverages vulnerable PCs to install itself on Android mobile devices. Learn how to foil this latest exploit.
Beware trojans on video codec sites (amongst others)
This sort of persistent malware hit my daughters laptop after she foolishly accepted a download from a site to access more free videos. Because I had accidentally left logging enab...
what makes you think
There are some key things to consider. 1) is your computer fully O/S patched? - this means running Windows Update (or the equivalent apple O/S update) until all critical and sugg...
10+ applications for getting down to business with Windows Mobile 6
10+ applications for getting down to business with Windows Mobile 6


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- Home
- Maxpedition
- Fixed Blade Knives
- Maxpedition Fixed Blade Knives
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Fixed Blade KnivesAt Maxpedition, they believe that the best knife is the knife you have on you. Maxpedition founder Tim Tang draws on his passion for tactical knives and a decade of collaborations with the industry's top custom knife makers to debut this design. |
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Part Number: MXLGEO Part Number: MXLFSH Part Number: MXMFSH Part Number: MXMGEO Part Number: MXMLCP Part Number: MXMSCP Part Number: MXLLCP Part Number: MXLSCP |