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Playing Tennis? Dogs Make Surprisingly Good Ball Boys
Dogs working as ball boys in a tennis match? We "love" that idea.
Dogs working as ball boys in a tennis match? We "love" that idea.
While "Awww" might be the perfect name for a puppy since that's the first word many people make when seeing one, it has yet to catch on. In fact, it seems like pet owners aren't changing at all when it comes to picking a name for their puppies.
I've got the cure for your Monday morning blues!
With Halloween right around the corner, there is lots to do in the Evansville area for all ages!!!
Need a smile? This should do the trick.
Interspecies cooperation can be a beautiful thing.
Gather up the family, especially those four-legged members, and enjoy a day of activities while raising money for the Vanderburgh County Humane Society.
I'm not usually the guy who posts the "cute dog does something cute" videos on our website, but this video was just too much for me to not share.
Their bark is worse than their bite. In the most "all talk, no action" example you will ever see, two dogs bark like crazy at each other without seeming to realize they could get physical since the fence separating them ends.
A video gone viral shows Animal Control dramatically breaking a window to rescue a dog that was locked in a hot car for at least 35 minutes.
With summer here, it is inevitable that we will see some poor dog locked in a car on a hot day. Why are people still doing this?
With summer here, every dog owner in the Tristate is out walking with their dogs, but are you doing it right?


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Brothers and sisters
Clauder, Jos. (Joseph)
Harris, Chas. K. (Charles Kassell)
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Kingore, Margaret
Man-woman relationships
Mistaken identity
American Popular Song Sheet Covers, 1890-1922
The New York Public Library for the Performing Arts / Music Division
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Image ID: 1992890
Must we say good-bye forever, Nellie dear? / words and music by Chas. K. Harris ; arranged by Jos. Clauder. [Must we say good-bye forever, Nellie dear? [first line of ch...]
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subset: commoncrawl


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- Episode Description
The guys arrive in Arizona, 1547, as a technician named Niman kills a scientist. After a shootout, he flees into the Tunnel. Niman is a spy who has planted a nuclear device in the complex. The guys need to find Niman to get him to reveal the location of the bomb. They lure him in with a fire but he slips, and the Project transfer Doug and Tony after him to 1,000,000 A.D. Niman is already there and has established himself with the ruling clique. The guys get the info on the detonation time, bypass a force field, and with the aid of a local female "defective" manage to get to Niman. The Project transfers everyone, including two of the future-types, back to 1,000,000 B.C. After some running around from dinosaurs, they rescue Niman from a quicksand pit in return for the location of the bomb. The head alien eventually comes around and forces Niman to give the location of the bomb which they defuse. Everyone ends up in a giant bee hive and the Project gets everyone but Niman out.moreless
- Cast & Crew
Lee Meriwether
James Darren
John Zaremba
Whit Bissell
Robert Colbert
- Fan Reviews (0)
- Be the first to write a review!
- Trivia & Quotes
Notes (1)
Was part of the compilation movie "Aliens From Another Planet."
Trivia (3)
When Doug first meets up with Tony in 1 million BC, his shirt is clearly torn and blackened. However, by the time he puts his jacket back on, the shirt is still torn, but is nowhere near as dirty as it was.
We are told that the time travellers have been whisked back one million years into the past - where they encounter dinosaurs (actually stock footage modern lizards masquerading as dinosaurs from the Irwin Allen "Lost World" movie). However, the last dinosaurs diappeared 65 million years ago.
Watch the guy in the yellow suit with a clipboard as Niman comes running out shooting. Everyone else ducks and cowers--he just kind of tries to blend into the console.
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Country House in Italy - Marche
From $101 / night
Hide Property Details
- 3 bedrooms
- 3 bathrooms
- Sleeps 5
- House
Description from the owner
We rent a typical and well-kept farmhouse, a short walk from the historic center of Cupramontana (Ancona): member of the national association "Città del vino", Cupramontana is nowadays known as the capital city of the Verdicchio wine.
Surrounded by a large garden with a variety of trees and plants, an orchard and over eighty olive trees, the property is yet easy to reach.
Ideal to relax and spend quiet moments in the open air, we will advise you on how to explore the surrounding area (hills, sea, mountains, caves, nature reserves, wine tasting tours and sports).
Country House in Italy - Marche
Cupramontana, Marche, Italy
What's Nearby:
Additional Location Information
Cupramontana got its name from "Cupra": goddess of fertility and love. On this territory was brought to live a civilisation of traditional life and cultivation of the soil. During the greek-gotic battle in the VI century, the old roman village Cupramontana was completely destroyed and forgotten for ages. It were first the benedict monks and afterwards between the VIII and XI century the camaldolesian monks, who reintroduced the cultivation of vineyards. The viniculture would increase over the years and already in the 16th century you could find vineyards growing together with fieldmaple (acer campestris), a technique until recently in use.
In the 18th century they even got an overproduction, so they started exportation to other regions.
From then on, the Verdicchio grape, which grew perfectly in the local hilly soil and microclimate, became the most used grape in the area.
By car: Highway A14 (exit: Ancona-Nord) - SS76 direction Roma (exit: Cupramontana)
By train: The nearest stations are Jesi and Castelplanio
By plane: Airport Raffaello Sanzio Falconara (Ancona)
Sagra dell'uva (Festival of the Grape - Every year on Octobers' first weekend)
Eremo dei Frati Bianchi (Monastry of the white monks)
Abbazia del Beato Angelo (Monastry of the Beato Angelo)
Grotte di Frasassi (Frasassi Caves)
Parco Naturale Gola della Rossa e di Frasassi (Regional Park of the Gola della Rossa and Frasassi)
Parco Naturale Monte Conero (Regional Park of the Monte Conero)
Parco Nazionale dei Monti Sibillini (National Park of the Monti Sibillini)
Senigallia and its "Velvet Beach"
More About This Location
Rural retreats
- Alarm Clock
- Linens Provided
- Local Guides/Maps
- Housekeeping Optional
- Central heating
- Towels Provided
- Soap/Shampoo Provided
- Washing Machine
- Parking
- Refrigerator
- Dishwasher
- Paper Towels Provided
- Freezer
- Television
- Stereo or CD player
- Porch
- Garden
- Outdoor Dining Area
- Pet friendly - ask
- Smoking allowed - ask
- Suitable for children - yes
- Suitable for the elderly - ask
- Wheelchair accessible - ask
Have you stayed here?
This rental is awaiting reviews from past guests. Help out travelers and the owner by being the first to write a review!
Here 3 more rentals located nearby.


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TR? Slim Line is a broad line of wide-screen projected capacitive touch monitors that bring and advanced consumer-product touch experience to the industrial market.
Easy To Deploy
Plug-and-play ready monitor and powered with 12V DC. Power adapter supplied.
Sophisticated Bezel-Free Design
A smooth touch surface across the entire front face of the monitor for refined aesthetics and easy cleanability.
Increased Touch Points
TR? Slim Line monitors can handle up to 4 touch points for increased functionality and gesture capability.
Download to learn more.
Topics: Display Technology , Interactive / Touchscreen , Monitors , Touchscreens
Companies: Touch Revolution


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The hotel in itself is okay, even though it could use to be cleaner and better maintained - and given a much needed facelift. The problem really is the staff. Rude and incompetent doesn't even begin to cover it. For example, the girl at reception looked down her nose at me every time I had a question, as if I... More
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, ACCOR, Hotels.com, Priceline, Travelocity, Agoda, TripOnline SA, Odigeo and Tingo so you can book your Adagio Access La Defense Leonard de Vinci reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Adagio Access La Defense Leonard De Vinci Hotel Courbevoie


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Men's College Basketball | |||||||||||||||||||||||||||||||||||||||||||
· Coaching Changes · Conferences · Conference Stats · Gaming Matchup · Injuries (A-M) · Injuries (N-Z) · News · Current Odds · Live Odds · Schedule |
· Top25 Scoreboard · Full Scoreboard · Secondary Scoreboard · Statistics Polls: · AP · USA Today · Division II · Division III |
· Top-25 Analysis · Top 25 Results · Transactions More Basketball · CBA · NBA · Women's College · WNBA |
(Friday, November 20th) Final Score: South Carolina 69, South Florida 66 Charleston, SC (Sports Network) - Devan Downey accounted for 17 points as he led the South Carolina Gamecocks to a 69-66 win over the South Florida Bulls in the semifinals of the Charleston Classic at Carolina First Arena. Also scoring in double figures for the Gamecocks (4-0) were Dominique Archie and Sam Muldrow with 15 and 10 points, respectively. Muldrow also added six rebounds and six blocked shots in the outing as well. Augustus Gilchrist scored a game-high 19 points for the Bulls (3-1), followed by Dominique Jones with 17 points, nine rebounds and five steals and Jarrid Famous with 16 points in the losing effort. Despite missing all eight chances from behind the three-point line in the first half and shooting only 34.4 percent from the floor overall in the frame, USC trailed by just six points at the break, 35-29. The Gamecocks dialed up the defense in the second half, limiting USF to just eight field goals and allowing South Carolina to squeeze out the three-point win. USC got away with making only 2-of-17 shots behind the three-point line by forcing 17 turnovers on the night. Both teams will be back in action on Sunday as South Carolina goes after Miami-Florida and the Bulls challenge UNC-Wilmington. 11/21 00:48:56 ET |


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Reviewed By Stephen K (Dublin, CA) Reviewed for a 2014 BMW 5-Series —11/21/2014 9:57 AM
My 3rd or 4th Colgan bra. Fit like a glove. Although it took almost a year (!) for it to be available!
Reviewed By JERAD C W (PHOENIX, AZ) Reviewed for a 1997 BMW 5-Series —5/30/2014 10:31 PM
I wish it had the hole for the bmw sign.I love it ,it makes the car look more up to date and makes me wont more kool items to make it look even better.It fits like a glove no lie..Im going to talk my friend in to one for his car...


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Start learning with our library of video tutorials taught by experts. Get started
Learn how to create super-pro drum sounds for electronic dance music (EDM) productions.
Arrange songs for radio play and club remixes using four different digital audio workstations: Pro Tools, Ableton Live, Logic, and Reason.
Demonstrates four time-stretching remix techniques in four major digital audio workstations: Pro Tools, Logic Pro, Reason, and Ableton Live.
"Words cannot express how much you people at lynda.com have changed my life. I have learned more than I could have from reading books." —Joseph A.
more from our members »


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Small Sequin Pitchfork
Dress up your devil costume in true satanic style with this small sequin pitchfork. This wicked weapon comes with ruby red sequins that sparkle like hell fire and perfectly match the separately-sold set of mischievous horns and tail.
Forked Weapon
Put a fork in it - he's done! Have the last word when you wield the fork - finish off your costume with this fantastic fake weapon that looks totally real.
Pitchfork With Garter
Straight through the heart or on the edge of a pin - you decide when you wear the Pitchfork with garter to create or complete your sexy devil or devilishly sexy costume.
Pink Cookie Devil Kit
You'll look pretty cute for the symbol of the evil when you use this Pink Cookie Devil Kit to complete your costume. Set includes pink attachable tail with arrow head shaped end, skull detailed pitchfork and matching horned headband.
Complete any creepy Halloween costume with this scary sickle! This highly detailed, screaming skull sickle is the ideal weapon for warriors, reapers, and demons alike.
Devils Delight Adult Womens Costume
Light the way to fun on Halloween with this Devils Delight adult womens costume. The red, flame print, jacquard dress features a faux lace-up bodice, organza sawtooth hem and a light-up skirt, complete with devil horn headband, pitchfork, tail and cape with stand-up collar.
Sequin Devil Horns
Make Up Tips The devil is in the details like these fabulous Sequin Devil Horns. Take a walk on the wild side in this Highly Durable Plastic costume accessory. See if you can barter your soul for a Small Sequin Pitchfork, you hellion -- sold separately.
Child Sized Sickle
Slice fear into your young victims with this scary sickle! This child sized weapon comes with black staff and curved toy blade. Hunting down souls has never been easier than with this killer costume accessory.
Darling Devil Toddler Costume
…the exorcist just yet, there's still hope for the little one in this great kids costume, complete with red Velvet and Polyester Jumpsuit with long sleeves and attached tail, Cape, and Hood headpiece with horns. Perfect for poking or a hot photo op, get the Small Sequin Pitchfork, sold separately.
Devil Adult Fishnet Thigh Highs
You'll be one sexy devil when you wear these Devil Adult Fishnet Thigh Highs. The black mini diamond net thigh highs feature a red pitchfork applique at the thigh line.
Red Glitter Lips and Lashes Kit
…these delightful lips and lashes are made to match. If you're ready to heat things up, then this fierce set is the right one, including the black lipstick, amazing red glitter gel and sassy red and black eyelashes with cosmetic adhesive. Add horns and a pitchfork to unleash your inner hellion!
Game of Thrones Khal Drogo Arakh
Use the Game of Thrones Khal Drogo Arakh to prove you're the fiercest fighter in all the land. This official HBO licensed product features an authentic design right from the HBO series, including an intricately detailed handle. Pair this weapon with the Khal Drogo Wig & Beard (sold separately)…
Lil Devil Child Costume
You little devil! Be the hit of any Halloween event when you wear this adorable red, orange and yellow Lil Devil child costume complete with matching glovelettes, headpiece and pitchfork.


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Click on the pins for news on the proposed Western Mass casinos:
View Massachusetts Casinos in a larger map
Hard Rock International dumps Western Mass. properties associated with failed casino at Big E
By Robert Rizzuto | email@example.com
January 26, 2015, 8:30AM
Hard Rock recently sold one property it acquired when pursuing a Massachusetts casino license and transferred municipal lien certificates to the town for three others. Full story »
MGM Springfield's tentative construction timeline to open $800 million urban resort casino
By Robert Rizzuto | email@example.com
January 26, 2015, 6:00AM
As MGM Resorts International works to break ground on its estimated $800 million MGM Springfield resort casino, the company is estimating a 30-month construction timeline. Full story »
MGM Resorts International named one of best companies for diversity by Black Enterprise magazine
By Robert Rizzuto | firstname.lastname@example.com
January 25, 2015, 11:00AM
MGM Resorts International, the parent company to the MGM Springfield resort casino, was again named one of the 40 best companies in the nation for diversity by Black Enterprise magazine. Full story »
This week in casinos: MGM Springfield begins evicting tenants for construction; Wynn releases new Everett renderings; and more
By Robert Rizzuto | email@example.com
January 25, 2015, 6:00AM
A look at the casino news which made headlines across Massachusetts this week. Full story »
Homeless murder suspect from NYC arrested at Foxwoods Resort Casino
By Robert Rizzuto | email@example.com
January 24, 2015, 6:38PM
A homeless man wanted in connection with the stabbing death of another this week in New York City was apprehended on Friday at the Foxwoods Resort Casino. Full story »
Could the MGM Springfield casino inadvertently kill the sheriff's Western Mass. Correctional Alcohol Center?
By Robert Rizzuto | firstname.lastname@example.com
January 23, 2015, 6:00AM
While MGM Springfield has purchased every piece of property they need to build their $800 million resort casino in downtown Springfield, it seems the company's plan could kill a successful program managed by the Hampden County Sheriff's Office. Full story »
Attorney General Maura Healey tells Mass. Gaming Commission she plans strict enforcement of casino gaming law
By Robert Rizzuto | firstname.lastname@example.com
January 22, 2015, 4:50PM
As the state's top lawyer, Healey says consumer advocacy, especially when it comes to multi-national corporations running gambling operations in Massachusetts, will be a top priority. Full story »
Treasurer Deborah Goldberg asks for boost in lottery advertising budget to compete with casinos
By Shira Schoenberg | email@example.com
January 22, 2015, 3:08PM
Goldberg asked the legislature for an additional $2 million next year to help the lottery build its brand in the face of competition from Massachusetts' new casino gambling industry. Full story »
New renderings of planned Wynn Resorts casino in Everett revealed at Massachusetts Gaming Commission meeting
By Garrett Quinn | email@example.com
January 22, 2015, 1:11PM
The new design of the planned $1.6 billion Wynn Resorts casino in Everett was released to the public on Thursday at a meeting of the Massachusetts Gaming Commission. Full story »
$1.18 billion spent in real estate in Hampden County last year; boosted by MGM purchases
By Jim Kinney | email@example.com
January 22, 2015, 7:24AM
Without MGM, the total amount spent on real estate in 2014 would have only increased by 3 percent. MGM alone accounted for a quarter of the growth. Full story »
5 promises to watch from the MGM Springfield host community agreement
By Robert Rizzuto | email@example.com
January 22, 2015, 6:00AM
A look at 5 key promises Western Mass. residents should watch for as MGM Springfield works to open its $800 million resort casino in the Pioneer Valley. Full story »
'People's lawyer' - Attorney General Maura Healey - sworn in before 800-strong crowd at historic Faneuil Hall
By Shira Schoenberg | firstname.lastname@example.com
January 21, 2015, 6:11PM
Healey pledged to address numerous areas ranging from drug addiction to child protection. Full story »
Readers react to I-91 reconstruction: How will commuters get from here to there?
By Anne-Gerard Flynn | firstname.lastname@example.com
January 21, 2015, 12:59PM
Upcoming projects caused readers to think of Boston's Big Dig. Full story »
MGM Springfield begins delivering eviction notices; notifies public parking lots will close on March 1
By Robert Rizzuto | firstname.lastname@example.com
January 21, 2015, 8:50AM
Tenants in the buildings it now owns within the casino's 14.5 acre footprint in the South End of Downtown Springfield have begun receiving notice they have to move by Feb. 28. Full story »
Springfield councilors favor 3-year ban on MGM casino jobs for officials leaving office
By Peter Goonan | firstname.lastname@example.com
January 20, 2015, 7:24PM
The City Council may vote on the casino ethics ordinance at its next meeting in February. Full story »


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RIPE NCC Membership - Developments After Reaching the Last /8
On 14 September 2012, the RIPE NCC started allocating IPv4 addresses based on the last /8 policy. With more than two years passed, we look at the effects this had on membership numbers and demographics. We also look at what the last /8 policy meant for IPv6 uptake.
Visualising IPv4 and IPv6 Tweets
This time we explored Twitter feed visualisation with CartoDB, a map visualisation tool.
Year in Review and Looking Ahead to 2015
RIPE NCC Managing Director Axel Pawlik recently gave an interview about what he sees as the most important developments of 2014 and looks ahead to the big issues in 2015.
IPv6 to Secure Business Continuity
Every few months somewhere somebody will tell you that the sky is falling and the end of the Internet is close. The reasons brought up vary through a broad spectrum from superior technology to the lack of capacity. To a large extent people in the industry have become immune to these messages, for they are either unrealistic or in cases where the threat was real, the Internet responded in its usual resilient ways, adopting to the changing environment. It is this remarkable flexibility and the constant search for optimisation that has made Internet seep into every little corner of our lives and businesses.
The IPv6 Analyser
The IPv6 Analyser is a toolset that offers our members a visual insight into all the allocations, aggregations and assignments they have made. It was announced a few weeks ago and we're seeing LIRs starting to use it. Please find below some more details about this tool.
Sending and Receiving Emails over IPv6
The change to IPv6 creates new challenges to keep spam out of email. Because of the sheer size of the IPv6 space, it seems more efficient to build a domain-blocking and reputation system rather than an IP-blocking system. But how do we ensure emails over IPv6 have an authenticated domain?
Report on IPv6 Security Test Methodology
The Dutch Institute for Applied Scientific Research (TNO) and a number of Dutch security companies have recently published a report on IPv6 security test methodologies.
Modifications to the IP Analyser to Reflect New Policy
We are in the process of implementing the policy regarding Post Depletion Adjustment of Procedures (2013-03). In this article we will give an overview of the changes we are making to the IP Analyser web interface and API, so you can accommodate your scripts and workflow. We intend to implement these changes on 16 April 2014.
How Many RIPE Atlas Probes Can Resolve IPv6-only Domain Names?
Each RIPE Atlas probe has at least one DNS resolver, indicated by a DHCP reply on the local network of the probe. Irrespective of the IP address of the resolver, this server may have IPv4 and IPv6 connectivity or only IPv4 connectivity. What is the percentage among RIPE Atlas probes?
Are We Ready to Switch Off IPv4?
At the RIPE 67 meeting in Athens, Greece, the RIPE IPv6 Working Group ran a little experiment to test the feasibility of an IPv6-only network and to identify challenges in user experience. While the results were highly encouraging, they indicated that there is still work to be done before IPv4 can be switched off once and for all.
14th Saudi Arabian IPv6 Task Force Meeting
The RIPE NCC recently participated in a meeting of the Saudi Arabian Task Force. A well-attended event, it included presentations and discussions about IPv6 deployment strategies, as well as presentations by operators reporting back on their successful IPv6 pilot projects and plans to roll out IPv6 in the first half of 2014.
RIPE Atlas - Packet Size Matters
This new RIPE Labs article talks about trying to send large packets over the Internet. Above a certain size, these packets will have to be fragmented, which is known to cause problems. In both IPv4 and IPv6, we see approximately 10% of RIPE Atlas probes that are unsuccessful in pings with fragmented packets, while they don't encounter problems with smaller unfragmented packets.
The Assisted Registry Check - Let Us Help You!
The Assisted Registry Check is the new name for the RIPE NCC's audit activities that have been improved using feedback from RIPE NCC members and the RIPE community. This improvement aims to make the process more efficient and less time consuming for Local Internet Registries (LIRs).
IPv6 ASNs - Network Size Matters
This article provides statistics about how much IPv4 address space is being announced by networks (ASNs) that are also announcing IPv6 address space. Currently this is about 70% of IPv4 address space.
IPv6 Internet Pollution
Following up from earlier experiments in which MERIT looked at pollution of IPv4 prefixes, Manish Karir and his colleagues now did an experiment with various IPv6 prefixes. The results can be found in this article.
IPv6 Security - An Overview
The advent of IPv6 changes not only the network components, but also the security field shifts. We see new types of attacks or at least variations of the attacks we know from IPv4. This article provides an overview of the IPv6 security vulnerabilities that arise with the launch of IPv6.
Evaluating the Effectiveness of Happy Eyeballs
The IETF has developed solutions that promote a healthy IPv4 and IPv6 co-existence. The happy eyeballs algorithm for instance, provides recommendations to application developers to help prevent bad user experience in situations where IPv6 connectivity is broken. We study the effectiveness of the happy eyeballs algorithm.
How Many RIPE Atlas Probes Believe They Have IPv6 (But Are Wrong)?
To check the connectivity of an IPv6 device with RIPE Atlas, one typically asks N probes to ping the target and deduces the reachability of the target from the percentage of failures. But RIPE Atlas probes, like many IPv6 devices, often believe they are IPv6-connected while they are not.
One Year Later: Who's Doing What With IPv6?
On the anniversary of the World IPv6 Launch, this article takes a look at the readiness of networks to deploy IPv6, using statistics from the RIPE NCC service region and beyond.
IPv6 RIPEness - Implementing the Fifth Star
In this article we present the first publicly available beta version of the fifth IPv6 RIPEness star. This measures real IPv6 deployment from LIRs in the RIPE NCC service region. The methodology is what we think to be the best compromise yet between simple and fair. In this first version, 573 LIRs (>9%) qualify for the fifth star.
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Fairfield Inn Shreveport Airport
Residence Inn Shreveport Airport
Fairfield Inn & Suites Marshall
Antioch TX
PointSavers offers up to 33% in point savings, depending on the hotel category and number of nights requested. This hotel is offering Seasonal Awards, so you can use fewer points when you book a stay during these dates.
6245 Westport Avenue Shreveport, LA 71129
42.9 miles from Antioch
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Conveniently located right off I-20 three minutes from nearby Shreveport Regional Airport (SHV), and nearby Frymaster/Manitowic, Calumet Lubricants, Teleperformance, and Independence Stadium.
4910 W. Monkhouse Drive Shreveport, LA 71109
44.5 miles from Antioch
At the Residence Inn Shreveport-Airport, we have perfected the extended-stay experience by combining all the comforts of home with our passion for making every guest feel welcome. Our 78 suites offer separate living and sleeping areas, plenty of space for
105 West Interstate 20 Marshall, TX 75672
47 miles from Antioch
The Fairfield Inn & Suites by Marriott is located in Marshall, TX off Interstate 20 at Highway 59 (Exit 617). We are located near the Harrison County Federal Courthouse and antiques in Marshall. We are also just 30 minutes away from the Shreveport.
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3D Systems has successfully outfitted Derby the dog with 3D-printed prosthetics, allowing him to run for the first time. Born with a congenital deformity characterized by small forearms and no front paws, Derby was previously only able to get around on soft surfaces.
Mutoh America has announced five open houses throughout 2015 at its learning facilities across the country. The open houses will include a two-part Caldera RIP software workshop series presented by Caldera.
A morning session, "Basic Introduction to Caldera," will be geared toward those who wish to gain a better understanding of the software's interface and functionality. In the afternoon, "Enhancing Your Workflow" will cover more in-depth topics such as profiling, spot colors, and automation.
In 2013, Austin, Texas' Parks and Recreation Department launched its Roving Leaders outreach program, which provides activities and services for kids in underserved communities. As part of the program, the department planned to outfit a trailer with an assortment of toys and activities, such as Xboxes and Wiis, and tow it with a dually truck to playgrounds and other sites around the city. They designed graphics for the truck and the trailer and selected Austin Extreme Graphics (www.vehiclewrapsaustintexas.com) to print and install them.
Perception Wide Format Media (www.perceptionwf.com) has released a repositionable wall graphic fabric made of 100 percent-recycled water bottles.
Photofab Eco-Ultra is designed for in-home and P-O-P graphics, decals, and wall murals.
CET Color (www.cetcolor.com) has introduced the Q5 series, a line of UV flatbed and hybrid printing presses. The series includes Ricoh Gen5 printheads, which feature grayscale printing with 600 dpi resolution, and an automatic height detection system that calibrates printhead distance for dot placement and image quality for varying media heights. An optional static suppression kit is available. Color configurations offered include CMYK + White and CMYKx2 + White. Max. print speeds range from 400 to 1152 sq ft/hr.
Most businesses employ a vehicle wrap as a rolling billboard to promote their identity. For entrepreneurs with a food truck, the wrap is their identity.
"A food truck wrap really defines the business," says Brett Brands, owner of Brands Imaging (www.brandsimaging.com) in Philadelphia. He's done more than 30 to date and expects to wrap another dozen this year.
Pantone has announced Pantone 18-1438 Marsala as the color of the year for 2015. Influences from around the world, including the fashion and entertainment industries, art, popular travel destinations, technology, sports, and more, guided the selection process.
Presto Tape has added to its PaperTac line of adhesive-backed wallcovering papers. PaperTac #328, like #329, is a 6-mil removable and repositionable paper designed for use in surface graphics, wall murals, or in place of traditional wallpaper. #328 is now compatible with solvent and eco-solvent inks as well as UV and latex. According to the company, PaperTac will not peel paint or damage walls.
Drytac has introduced JM63 Fuzion XD roll-to-roll laminator, designed for laminating vehicle wraps, creating window decals, and mounting graphics to substrates. Max. laminating width is 63 in. with a max. laminating speed of 20 ft/min.
Features include top roller with heat assist, nip pressure indicator, fold down front table, "hold-flat" paper in-feed guide, built-in flip-open storage compartments, non-stick silicone rollers, and more.
1. Nashville │ A life-size, digitally printed replica of Taylor Swift's tour bus is now housed in the Country Music Hall of Fame, which commissioned 12-Point SignWorks (www.12pointsignworks.com) and 1220 Exhibits for the project. The bus was installed two-and-a-half days with 3M Scotchcal Graphic Film with Comply Adhesive IJ35C-20 Matte White. Installers had just two feet of space between the building wall and the bus.


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MyWater Flavor Essences
MyWater Unsweetened, all-natural flavor essences for making lightly flavored seltzer or sparkling water. Adjust the intensity of the flavor by adding more or less flavoring. Each 40 ml bottle will make approx. 20 liters of flavored seltzer; MyWater comes in purses containing 3 bottles each.


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Plastered on Smiles
Posted Feb 21 2010 2:34pm
The last several weeks have been grueling and often painful. I have tried to plaster that smile on and keep truckin' along, but it is too much now. I have spent days where the tears just won't stop, but I don't know why I'm crying. I spent a full five days of contant crying! And other days are completely opposite-I laugh until I cry, but I don't know why I'm laughing.
I'm not so sure that I am being listened to at the neurologist office. I explain what is going on, but it seems as if no one is listening. Case in point *TMI Warning*, but perhaps this will help someone. I started having bowel problems last April. Loss of control of bowel movement problems. Embarrassing and humiliating, especially in public. Those who have been through this can only know what I mean. I mentioned it several times to my MS neuro office, and each time was told it was "progression of the diease". In November, it was so bad that the oopsies were happening a few times per week. Again, I mentioned it, but to no avail. At the end of November I went to my primary care physician, and I casually mentioned it just so he would know for his records. He sent me right over for an abdominal x-ray to check for colon blockage. Apparently, blockage of the colon would seem to act like constipation, but actually sometimes it acts like diarrhea and pushes by the blockage so quickly and hard that then there is an accident. The next day he called me to confirm that yes, there was blockage, and recommended I take an over the counter medication for constipation for 7 days, and to call if the problem was not resolved. Guess what? Not an accident since. I went for several months with this problem because I was not listened to. And it took a primary care, rather than a specialist, to hear what I was saying.
I've decided that tomorrow I call the MS center and get an appointment scheduled asap. I have pain that seems to be coming from within my bones on my rear end, then the pain shoots down my legs, mainly the left leg. So much pain that I end up taking Vicodin to take the edge off. At night, the pain gets worse. The fatigue is out of control now. I woke up this morning at 11am, and that was only because Brian finally came up to get me up. I would probably still be sound asleep. I was awake for about 3 hours (and cried again for no reason), then took a nap for about two hours. And now I am totally ready to go crawl into bed. When Brian gives me hugs, sometimes it hurts, even if he doesn't squeeze hard. Why would a hug hurt? I have almost constant headaches now, for about the last two or three weeks. The only good thing I can say about that is that I haven't had a full-blown migraine *knocking on wood*. My vision blurs on and off in my right eye. But if I say anything to my doc, she says "wait and see". She finally gave me Prednisone after telling her the wait and see didn't work, but she gave me a taper dose that lasted about three weeks. 60mg per day down to 10mg per day. I have been off of that for a few weeks and I honestly feel worse and hurt more than I did before.
Yup, I'm bitching. Yes, I'm angry. I just want answers. Should I request an MRI? I last had the brain MRI Jan 2009, and before that the brain MRI was Aug 2008. Cervical MRI was Aug 2008. MRI in January 2009 showed several new and active lesions. It seems they would have wanted to follow up on that to see that things have slowed down? Several new and active lesions within 5 months? And why not check to see if there are new cervical lesions? Not sure...so many questions.......
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All I could think about when I saw her was that she could be the mother of my future first round draft picks
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She must look like hulk hogan with a twat.
aka Brooke Hogan ;)
on another note, autocorrect changes 'Hogan' to 'gigantic' on my phone....huh. appropriate I suppose.
Thunder UP!!
So you're the husband of future Oklahoma State stars?
Reggie to Kim?
She must be black or Dominican
First round picks means dimes. Hot girls are first round picks. The uglier they are, the later the rounds. A pretty good rating scale. There is a lot of leeway.
Hopefully not your baby's momma...
Or Reggie about Kim, rather
After he got sober he realized she was just some whore who would abort anyway. Oh so Tebow maybe. Glass half empty or full.
Future Andrew Lucks!
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Whale crashes into sail boat – was it harassed?
The whale that crashed into a sailboat off Cape Town, South Africa this week left more than a giant splash and a floating pile of wreckage in its wake. There are also allegations that the whale was harassed. The sailors on board the boat told the Today Show they weren't following or otherwise antagonizing the [...]
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Flipboard: Is the iPad's killer app finally here?
How do you know when your online service or app is a hit? When so many people start to use it that your servers are too overwhelmed to actually let them. By that benchmark, Flipboard is a huge hit. Billed as a "personalized social magazine" for Apple's iPad, it's a free app that pulls words and [...]
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Vaseline's skin-lightening Facebook app: Is it beyond the pale?
Vaseline is the last company you'd expect to cause any friction. But its new Facebook app promoting its skin-lightening cream sold in India has gotten anything but a smooth reception. The app lets users drag a line across a screen to lighten their profile pictures, similar to what Vaseline Men UV Whitening Body Lotion is [...]
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Colt McCoy ties the knot, and Tim Tebow gets a shoutout
By Kate Shellnutt Former Texas Longhorns star quarterback Colt McCoy – who'll play this season with the NFL's Cleveland Browns - got hitched at an Austin church on Saturday, McCoy, 23, married his girlfriend of two years, Baylor University alum Rachel Glandorf, also 23, at the Bible-based Westover Hills Church of Christ. He attended services [...]
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Moko, the bottlenose dolphin, was a friend and a pest He played with swimmers in New Zealand's Bay of Plenty. But he also stole their boogie board and nibbled on their toes. Fishermen knew that he would swipe the catch right out of their nets. In short, he was a beloved character in a Dennis [...]
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Drive test: Western Star's newly released 5700XE on-highway tractor
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Blizzard shuts schools, roads in upper midwest
March 31 (Reuters) - A spring blizzard swept through the northern U.S. Plains and upper Midwest on Monday causing treacherous driving conditions under heavy snow and strong winds that forced schools and some state offices to close.
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Microsoft will release Windows 8 soon in New York. There will display the Windows RT Tablet PC and other OEM manufacturers Windows 8 devices. Windows 8 will release four versions, the official retail price has not been announced, and there are only three upgrade programs. Windows 8 will be on sale simultaneously on October 26 in the global.[......]
According to media reports, the TechBargains.com site recently launched an investigation on whether the user is willing to buy Apple's upcoming iPad mini, the results showed that one-third of the respondents don't intend to buy iPad mini as it's too small, one-fifth believed that the iPad mini price may be too expensive.
The findings also sh[......]
According to media reports, the market research firm Forrester said in a report, affected by the Google Android and Apple iOS operating systems, smart phones and tablet PCs make Microsoft computing device operating system market share decline to about 30% from approximately 70% 4 years ago.
In order to reverse the decline of the operating sy[......]
According to the blog site GizmoChina report, less than 12 hours after the Apple iPad mini released, a cheap copy version iPad mini called GooPad mini will be listed in November.
GooPad was once known as the best imitation of the 9.7-inch iPad, but it is not just satisfied with this. After Apple introduced iPad mini, GooPad mini followed it[......]
According to media reports, the well-known Apple news commentary blog Daring Fireball author John Gruber thought that the real name for iPad mini might be called iPad Air, and it will not be equipped with Retina display, while the sale price of this product will be lower than the current iPod touch.
Gruber thinks that the new iPad does not u[......]
With Windows 8 operating system release date approaching, the major PC manufacturers have accelerated the pace of introduction new products. Asustek Computer will hold a conference for the Windows 8 new products at local time on October 23 in New York. Seen from the text of the invitation to the media, Asus did not reveal any information about[......]
According to media reports, Google has quietly updated its mobile payment service Google Wallet website, to promote the upcoming new version Google Wallet.
Users can apply for an invitation code in Google Wallet website. Google Wallet supports iPhone, Android and other devices. This indicates that Google will give up its early reliance on sp[......]
Apple's conference will be held in U.S. time on October 23, when the long-rumored iPad mini is likely to be published. Although the market generally believes that Apple's new iPad will be the protagonist of the conference, the latest news from French blog website iGen.fr, that Apple might also introduce an upgraded version of the independent e-book[......]
Lenovo Group's vice president of mobile terminals research and development division general manager Chen Wenhui, said in Beijing, Lenovo istore new V5.0 version has already been on line, but the Lenovo has no plans to launch application store for Win8 temporarily.
Chen said, currently the applications in Lenovo istore are based on Android system[......]
A few days ago, Google sent an invitation to the media to participate in a press conference held in New York City on October 29. This Google news conference held in San Francisco is on the same day with Microsoft Windows Phone 8 press conference held in other areas in the world. TheNextWeb reports that it has learned all the information of the ne[......]


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Researchers at the Institute of Molecular Pathology (IMP) in Vienna present novel method to study the activity of specific brain regions in moving flies.
In a joint effort with collaboration partners from the Vienna University of Technology and a lab in the USA, the team of Andrew Straw at the IMP developed a special device for the thermogenetic control of flies. This tool, called FlyMAD, enabled the scientists to target light or heat to specific body regions of flies in motion and to analyse the animals' brain cells. Compared to other techniques, FlyMAD allows highly improved temporal resolution. Using the new technology, Straw and his colleagues got new insight into the role of two neuronal cell types in courtship behavior of flies. The results of the study will be published online in Nature Methods on May 25 (doi 10.1038/nmeth.2973).
This composite image shows a laser being aimed at a walking fly using the FlyMAD system.
Matt Staley and Dan Bath, JFRC, HHMI
A male Drosophila raises a wing and 'sings' due to neuronal activation of song neurons.
Dan Bath, JFRC, HHMI
The fruit fly Drosophila Melanogaster represents an ideal experimental system to analyse circuit functions of brain cells (neurons). In the past, it was not possible to specifically control the activity of neurons in moving flies. Andrew Straw and his team have now overcome this barrier.
Rapid mind alteration in moving flies
Straw and his co-workers are interested in the mechanisms underlying cell circuits in the fly brain. Straw's group concentrates on the control of complex behaviors such as courtship. In order to better understand how different neuronal circuits work together, Straw and his team developed FlyMAD ("Fly Mind Altering Device"), an apparatus using a video camera to track the flies' motion in a box. FlyMAD allows simultaneous observation of several flies and targeted irradiation of specific body regions of these animals. By combining the sensitive methods of optogenetics and thermogenetics, the researchers were able to specifically alter neural pathways in the fly brain with FlyMAD.
The novel technology of thermogenetics uses genetically modified, temperature-sensitive flies. Upon irradiation with infrared light and the concomitant rise in temperature to 30 degrees Celsius, these animals change certain aspects of their behavior. This does not happen at a control temperature of 24 degrees Celsius. Compared to other commonly used methods, FlyMAD applies a highly improved temporal resolution. Infrared-induced activation or repression of specific neurons and the following change in the animals' behavior occur within the fraction of a second.
The application of visible light to certain genetically engineered flies can also induce alterations of their brain. FlyMAD thus represents an absolute novelty for fly research, as optogenetics has been restricted to mice so far.
New insight into courtship behavior of flies
Straw and his co-workers tested FlyMAD by analyzing already known reactions of genetically modified flies to light and heat. As this proof-of-principle showed that FlyMAD worked reliably – for example by making the flies "moonwalk" - the researchers went on to use their method to tackle new scientific questions. In a thermogenetic set up, they investigated a certain type of neurons that had been linked to the flies' courtship song in earlier experiments. Taking advantage of the better temporal resolution of FlyMAD, the scientists were able to characterize the role of two neuronal cell types in the brain in more detail. They could show that activity of one type of neurons correlated with a persistent state of courtship, whereas the other cell type was important for the action of "singing". In the experiment this became obvious when males tried to mate with a ball of wax, circled it and started vibrating their wings after stimulation with the laser beam.
FlyMAD allows combination of optogenetics and thermogenetics
In the future, Straw wants to combine the activation of flies both by light and by heat in one experiment – that is feasible with FlyMAD. This would allow the activation or repression of different genetic elements in one fly. "FlyMAD offers the fantastic opportunity to address many of our questions. We could, for example, analyze how single neurons function in a cascade within the neuronal circuit", Straw emphasizes the potential of his work. Ultimately, new insight into the function of the fly brain can also be applied to the network of cells in the mammalian brain.
Original Publication
Daniel E. Bath, John R. Stowers, Dorothea Hörmann, Andreas Poehlmann, Barry J. Dickson and Andrew D. Straw. FlyMAD: Rapid thermogenetic control of neuronal activity in freely-walking Drosophila. Nature Methods, doi 10.1038/nmeth.2973, 2014
This work was funded by a postgraduate scholarship from Canada, an ERC starting grant, a WWTF grant, an ERC Advanced Grant and by IMP core funding.
Illustrations to be used free of charge in connection with this press release can be downloaded from the IMP website: www.imp.ac.at/pressefoto-flymad
About Andrew Straw
Andrew Straw studied biology in Los Angeles, USA, and obtained his PhD in Adelaide in 2004 for his dissertation in the field of neurobiology. He worked as a Postdoc and Senior Postdoc at Caltech in Pasadena, USA, and became Senior Research Fellow there in 2010. Since 2010, Straw holds a position as Research Fellow at the IMP in Vienna where he has his own independent research group. His work is partly funded by an ERC Starting grant.
About the IMP
The Research Institute of Molecular Pathology (IMP) in Vienna is a basic biomedical research institute largely sponsored by Boehringer Ingelheim. With over 200 scientists from 37 nations, the IMP is committed to scientific discovery of fundamental molecular and cellular mechanisms underlying complex biological phenomena. Research areas include cell and molecular biology, neurobiology, disease mechanisms and computational biology.
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Andrew Straw, PhD
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Dr. Heidemarie Hurtl | idw - Informationsdienst Wissenschaft
Further reports about: > ERC > IMP > activity > animals > flies > fly > genetically > mechanisms > neurons > optogenetics
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This is gonna be fun!!!
Ducks exposed again. Seems like this is a yearly theme for them. Coach is optimistic though, saying his defense was playing great when they just got pounded on for 20 plays over nine minutes.
"Turn off the lights, the parteeeees over"
Hey, how 'bout dem Ragin Cajuns tonight? 41 points in a win over the Trojans!
Collecting more taxes than is absolutely necessary is legalized robbery. Calvin Coolidge
12 Play - 6 minute drive average for Stanford.
If that holds up, they only need 2 more possessions to put this game away.
Ya'll think Schaffer will feel bad? What about that poor kid on Oregons team, D'Anthony Thomas, who said they would put up 40 on stanford. Guess he was only talking about rushing yards!!
The only difference between this game and that boring, smash-mouth style of football historically played in the SEC is only one of these teams can play that way. It happens to be the team that's winning at this point in the game.
Game ain't over yet Bon.
A turnover, muffed punt, 3 and out and all hell breaks loose. That TD only took 1:30.
TD 10:11 Marcus Mariota pass complete to Daryle Hawkins for 23 yards for a TOUCHDOWN. Matt Wogan extra point GOOD.Drive info: 5 plays, 60 yds in 1:29
Watch Highlight7 26
Last edited by Dustin D; 11-07-2013 at 11:41 PM.
Dun Dun Dunnnnnnnn!!!!


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General Topics
General Messages
> Who will win the Linz Final?
View Full Version :
Who will win the Linz Final?
Oct 28th, 2006, 04:22 PM
Ladies and Gentleman, all vote now.
Oct 28th, 2006, 04:27 PM
i really hope maria can do it but she looked really exhausted and i dont think winning the final will make a difference in getting to #1 cause i think either way shell have to go so far! but im not sure petrova was quite impreessive in her semi and maria looked so tired i just hope she has enough energy left to take the title keep fighting masha! you can do it! :) good luck!
Oct 28th, 2006, 04:27 PM
Nadia in 2! She's amazing this week.
Oct 28th, 2006, 04:32 PM
Nadia will squash Maria leaving a big splotch.
Oct 28th, 2006, 04:46 PM
Great finale...Gotta go with Masha though...7-6, 6-7, 7-6 :)
Oct 28th, 2006, 04:49 PM
I think Nadia is fresher and that she will win :sad: :sad: but I hope Masha will prove me wrong.Davai Masha! :rocker:
Oct 28th, 2006, 04:54 PM
nadia or masha ?:scratch: well i will have to stick with what i've always supported : masha in 3 sets :)
Oct 28th, 2006, 04:55 PM
Masha 7-5 6-4
Oct 28th, 2006, 04:57 PM
It's more important for Nadia to win
Beat Sharapova in a meaningful match,
and withdraw next week
Oct 28th, 2006, 05:03 PM
Masha has too much pride to tank a final... so she'll win!
Of course she'll be dead tired but she gets a week off b4 YEC
Oct 28th, 2006, 05:13 PM
i think nadia will surprise everyone and maybe win quite easily. something like 6-3 6-4
i think it really depends on how both of them are serving though ;)
Oct 28th, 2006, 05:16 PM
That's going to be another match in which we'll see hard hitting girls. Maria loves
when her opponents play like that so I think she'll win this match but in 3 sets as Nadia is playing great tennis this week.
Oct 28th, 2006, 05:19 PM
It will be a really great final,but I hope Maria will win,although it will be tough against Nadia,she's playing great!Go Mariaaaa:bounce:
Oct 28th, 2006, 05:20 PM
Nadia in 3 sets. 6/4 3/6 7/5
Oct 28th, 2006, 06:12 PM
I'm hoping Maria, but realistically, I see Petrova winning this. She's just playing so well and seems so fresh at the moment, really having easy matches after easy matches. Maria has looked just tired and spent, and even though all her matches have been in straights, she's struggled in 5 out of 6 sets. I hope she can pull together one more win, then rest for a whole week and get her energy back up.
Oct 28th, 2006, 06:22 PM
Nadia beat Amelie in the Doha final, and Justine in the German Open final.
Even if she wins this, she still has to beat these players in majors and big YEC matches
Oct 28th, 2006, 06:28 PM
Maria needs to serve a bit better than today. She raises her level against the best players anyway, so I'd expect her to win in 3 sets. That said I wouldn't be surprised if Nadia won, considering the wonderful form she's been in.
Oct 28th, 2006, 07:35 PM
wow 24 votes apiece...
I say Sharapova. She knows how to step it up when she needs to.
Oct 28th, 2006, 07:42 PM
true,nadia did beat momo and jhh in two finals but don't u think masha isn't comparable to others? she's something between a #1 and the best player at the moment and i don't think masha is goin' to lose inthe next few times.
masha in straight sets:7-5 6-2
Oct 28th, 2006, 07:46 PM
wow 24 votes apiece...
I say Sharapova. She knows how to step it up when she needs to.
yeah and i was the 25th to voted for masha! i counted it as masha now does lead with one shot!!
Oct 28th, 2006, 07:50 PM
I've been waiting for this re-match all year ....:drool:
Sharapova is gonna get badly pe-trov-ed in three bad-tempered sets 6-2, 6-7, 6-4 :bounce:
Oct 28th, 2006, 07:58 PM
Oct 28th, 2006, 08:53 PM
Sharapova in two tiebreaks.
Oct 28th, 2006, 08:55 PM
Sharapova in three 6-4, 2-6, 7-5
Oct 28th, 2006, 10:12 PM
i really hope masha can do this! ha ha petrova is winning the other poll for the final and masha is winning this one! lol i wonder which poll will turn out to predict the winner! :)
Oct 28th, 2006, 10:15 PM
Looking forward to the final. Hard to say, victory in 3 sets to Maria Sharapova
Oct 28th, 2006, 10:21 PM
damn now its all even! :( please get enough energy together to win masha please! :)
Oct 28th, 2006, 10:24 PM
Petrova 6/3 7/5
Oct 28th, 2006, 11:34 PM
Sharapova's mental toughness will get her through 76 76.
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Staff profile - Aydogan Ulker
Dr Aydogan Ulker
Position: | Senior Lecturer |
Faculty or Division: | Faculty of Business & Law |
Department: | School of Accounting Economics & Finance |
Campus: | lb4.405, Melbourne Burwood Campus |
Phone: | +61 3 92443040 +61 3 92443040 |
Email: | email@example.com |
Current Employment: Senior Lecturer of Economics
Deakin University, School of Accounting, Economics and Finance, July 2008-Present
Previous Employment: Research Fellow of Economics
Australian National University, Research School of Social Sciences, July 2003-July 2008
Bachelor of Science in Physics, 1995, Bogazici University, Turkey
Bachelor of Science in Mathematics, 1995, Bogazici University, Turkey
Master of Science in Economics, 1998, University of Texas at Austin, U.S.A
Doctor of Philosophy in Economics, 2002, University of Texas at Austin, U.S.A
American Economic Association
Royal Economic Society
Economics Society of Australia
Econometrics Society
European Society of Population Economics
Teaching Interests
Labour Economics, Econometrics, Health Economics
Subjects and units currently teaching
MAE304 Labour Economics
MAE356 Analytical Methods in Economics and Finance
Knowledge areas
Labour Economics, Applied Microeconomics, Econometrics, Health Economics
Research interests
Health Economics, Labour Economics, Applied Microeconometrics
Selected Publications:
Private Ancillary Health Insurance Status and Utilisation of Dental Services in Australia. Economic Record , Vol. 89, Issue 285, pp. 194-206, 2013 (with Mike Kidd and Sandra Hopkins).
Determinants of Maternity Leave Duration in Australia: Evidence from the HILDA Survey, Economic Record, Vol. 87, Issue 278, pp. 399-413, 2011 (with Cahit Guven).
Robustness in Health Research: Do Differences in Health Measures, Techniques, and Time Frame Matter? Journal of Health Economics, Volume 27, Number 6, December 2008, pp 1626-1644 (with Paul Frijters).
Household Structure and Consumption Insurance of the Elderly. Journal of Population Economics, Volume 21, Number 2, April 2008, pp 373-394.


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Publications (111)863.56 Total impact
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ABSTRACT: Chronic pancreatitis (CP) represents a significant health care burden in the United States. Diagnosing it early and accurately is important for the efficient management of these patients. However, the early diagnosis of CP, when structural and functional pancreatic changes are subtle, remains difficult. Complicating this is the large cohort of patients with nonspecific abdominal pain who are often suspected of having early CP and who utilize significant health care resources in attempts at diagnosis and management. We present a review of the current diagnostic tests available for making an early diagnosis of CP. We further report our approach to patients suspected of having CP based on the available literature.Pancreas 03/2015; 44(2):173-180. · 3.01 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To determine the clinical presentation, diagnostic variables, risk factors, and disease burden in children with chronic pancreatitis. We performed a cross-sectional study of data from the International Study Group of Pediatric Pancreatitis: In Search for a Cure, a registry of children with acute recurrent pancreatitis and chronic pancreatitis. Between-group differences were compared using Wilcoxon rank-sum test. Among 170 subjects in the registry, 76 (45%) had chronic pancreatitis; 57% were female, 80% were white; median age at diagnosis was 9.9 years. Pancreatitis-predisposing genetic mutations were identified in 51 (67%) and obstructive risk factors in 25 (33%). Toxic/metabolic and autoimmune factors were uncommon. Imaging demonstrated ductal abnormalities and pancreatic atrophy more commonly than calcifications. Fifty-nine (77%) reported abdominal pain within the past year; pain was reported as constant and receiving narcotics in 28%. Children with chronic pancreatitis reported a median of 3 emergency department visits and 2 hospitalizations in the last year. Forty-seven subjects (70%) missed 1 day of school in the past month as the result of chronic pancreatitis; 26 (34%) missed 3 or more days. Children reporting constant pain were more likely to miss school (P = .002), visit the emergency department (P = .01), and experience hospitalizations (P = .03) compared with children with episodic pain. Thirty-three children (43%) underwent therapeutic endoscopic retrograde pancreatography; one or more pancreatic surgeries were performed in 30 (39%). Chronic pancreatitis occurs at a young age with distinct clinical features. Genetic and obstructive risk factors are common, and disease burden is substantial. Copyright © 2015 Elsevier Inc. All rights reserved.Journal of Pediatrics 12/2014; · 3.74 Impact Factor -
Article: Structuring the patient–physician encounter: Joint creation of an actionable roadmap to health
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ABSTRACT: The patient׳s experiences and costs related to their care are largely dictated by each patient–physician interaction along the continuum of care. However, the amount of time that a physician spends with a patient creating a medical action plan is highly variable and often not related to the severity or complexity of the patient׳s condition. Adding a structured process to guide and inform patient–physician encounters, including outlining expectations and follow-up by both sides is needed. Addressing these barriers to the physician–patient relationship would reduce variation in care, minimize unnecessary trial and error tactics and instead focus on predicted cost effective actions.Healthcare. 07/2014; - [Show abstract] [Hide abstract]
ABSTRACT: The critical fatty acids Docosahexaenoic Acid (DHA) and Arachidonic Acid (AA) decline in preterm infants within the first postnatal week and are associated with neonatal morbidities, including bronchopulmonary dysplasia (BPD). DHA and AA are precursors to downstream metabolites that terminate the inflammatory response. We hypothesized that treatment with Resolvin D1 and/or Lipoxin A4 would prevent lung injury in a murine model of BPD.PLoS ONE 06/2014; 9(6):e98773. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are rare and poorly understood diseases in children. Better understanding of these disorders can only be accomplished via a multi-center, structured, data collection approach. The INSPPIRE Consortium (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) was created to investigate the epidemiology, etiologies, pathogenesis, natural history and outcomes of pediatric ARP and CP. Patient and physician questionnaires were developed to capture information on demographics, past medical history, family and social history, medications, hospitalizations, risk factors, diagnostic evaluation, treatments and outcome information. Information collected in paper questionnaires was then transferred into REDCap (Research Electronic Data Capture), tabulated and analyzed. The administrative structure of the INSPPIRE Consortium was established and National Institutes of Health funding was obtained. Fourteen sites (10 in United States, 2 in Canada, and 2 overseas) participated. Questionnaires were amended and updated as necessary, followed by changes made into the REDCap database. Between September 1, 2012 and August 31, 2013, 194 children were enrolled into the study; 54% were female; 82% were non-Hispanic, 72% were Caucasian. The INSPPIRE consortium demonstrates the feasibility of building a multi-center patient registry to study the rare pediatric diseases, ARP and CP. Analyses of collected data will provide a greater understanding of pediatric pancreatitis and create opportunities for therapeutic interventional studies that would not otherwise be possible without a multi-center approach.Journal of pediatric gastroenterology and nutrition 05/2014; · 2.18 Impact Factor - Gastroenterology 05/2014; 146(5):S-4. · 12.82 Impact Factor
- JAMA surgery. 09/2013; 148(11).
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ABSTRACT: OBJECTIVES:The diagnosis of chronic pancreatitis in patients with characteristic symptoms but normal pancreatic imaging is challenging. Assessment of pancreatic function through secretin pancreatic function testing (SPFT) has been advocated in this setting, but its diagnostic accuracy is not fully known.METHODS:This was a retrospective review of patients who received SPFT at our tertiary care institution between January 1995 and December 2008 for suspected chronic pancreatitis. For all patients, medical records were reviewed for evidence of subsequent development of chronic pancreatitis by imaging and/or pathology. Patients were then categorized as "true positive" or "true negative" for chronic pancreatitis based on follow-up imaging or histologic evidence.RESULTS:In all, 116 patients underwent SPFT. Of the 27 patients who tested positive, 7 were lost to follow-up. Of the remaining 20 SPFT-positive patients, 9 (45%) developed radiologic or histologic evidence of chronic pancreatitis after a median of 4 years (1-11 years). Of the 89 patients who had negative SPFT testing, 19 were lost to follow-up. Of the remaining 70 patients, 2 were eventually diagnosed with chronic pancreatitis based on subsequent imaging/histology after a median follow-up period of 7 years (3-11 years). The sensitivity of the SPFT in diagnosing chronic pancreatitis was 82% with a specificity of 86%. The positive predictive value (PPV) of chronic pancreatitis was 45% with a negative predictive value (NPV) of 97%.CONCLUSIONS:In patients with suspected early chronic pancreatitis and normal pancreatic imaging, SPFT is highly accurate at ruling out early chronic pancreatitis with a NPV of 97%.Am J Gastroenterol advance online publication, 28 May 2013; doi:10.1038/ajg.2013.148.The American Journal of Gastroenterology 05/2013; · 9.21 Impact Factor - Gastroenterology 11/2012; · 12.82 Impact Factor
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ABSTRACT: Cystic fibrosis liver disease (CFLD) is a rapidly progressive biliary fibrosis, resembling primary sclerosing cholangitis that develops in 5-10% of patients with cystic fibrosis. Further research and evaluation of therapies are hampered by the lack of a mouse model for CFLD. Although primary sclerosing cholangitis is linked to both ulcerative colitis and loss of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel function, induction of colitis with dextran sodium sulfate (DSS) in cftr(-/-) mice causes bile duct injury but no fibrosis. Since profibrogenic modifier genes are linked to CFLD, we examined whether subthreshhold doses of the profibrogenic xenobiotic 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), along with DSS-induced colitis, lead to bile duct injury and liver fibrosis in mice that harbor loss of CFTR function. Exon 10 heterozygous (cftr(+/-)) and homozygous (cftr(-/-)) mice treated with DDC demonstrated extensive mononuclear cell inflammation, bile duct proliferation, and periductular fibrosis. In contrast, wild-type (cftr(+/+)) littermates did not develop bile duct injury or fibrosis. Histological changes corresponded to increased levels of alkaline phosphatase, hydroxyproline, and expression of profibrogenic transcripts for transforming growth factor-β(1), transforming growth factor-β(2), procollagen α(1)(I), and tissue inhibitor of matrix metaloproteinase-1. Immunohistochemistry demonstrated fibrosis and activation of periductal fibrogenic cells based on positive staining for lysyl oxidase-like-2, α-smooth muscle actin, and collagen I. These data demonstrate that subthreshold doses of DDC, in conjunction with DSS-induced colitis, results in bile duct injury and periductal fibrosis in mice with partial or complete loss of CFTR function and may represent a useful model to study the pathogenic mechanisms by which CFTR dysfunction predisposes to fibrotic liver disease and potential therapies.AJP Gastrointestinal and Liver Physiology 06/2012; 303(4):G474-81. · 3.65 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: There is limited literature on acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP) in children. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was formed to standardize definitions, develop diagnostic algorithms, investigate disease pathophysiology, and design prospective multicenter studies in pediatric pancreatitis. Subcommittees were formed to delineate definitions of pancreatitis, and a survey was conducted to analyze present practice. AP was defined as requiring 2 of the following: abdominal pain compatible with AP, serum amylase and/or lipase values ≥3 times upper limits of normal, and imaging findings of AP. ARP was defined as ≥2 distinct episodes of AP with intervening return to baseline. CP was diagnosed in the presence of typical abdominal pain plus characteristic imaging findings, or exocrine insufficiency plus imaging findings, or endocrine insufficiency plus imaging findings. We found that children with pancreatitis were primarily managed by pediatric gastroenterologists. Unless the etiology was known, initial investigations included serum liver enzymes, triglycerides, calcium, and abdominal ultrasound. Further investigations (usually for ARP and CP) included magnetic resonance or other imaging, sweat chloride, and genetic testing. Respondents' future goals for INSPPIRE included determining natural history of pancreatitis, developing algorithms to evaluate and manage pancreatitis, and validating diagnostic criteria. INSPPIRE represents the first initiative to create a multicenter approach to systematically characterize pancreatitis in children. Future aims include creation of patient database and biologic sample repository.Journal of pediatric gastroenterology and nutrition 02/2012; 55(3):261-5. · 2.18 Impact Factor -
Article: Do patient-accessible electronic medical records help or complicate shared decision making?
The virtual mentor : VM. 01/2012; 14(7):560-2. - [Show abstract] [Hide abstract]
ABSTRACT: QUALITY PROBLEM: Patients often do not fully understand medical information discussed during office visits. This can result in lack of adherence to recommended treatment plans and poorer health outcomes. We conducted a prospective quality improvement intervention at a large tertiary-care academic medical center utilizing the encounter form and studied the effect on patient satisfaction, understanding and confidence in communicating with physicians. The intervention included 108 patients seen by seven physicians in five sub-specialties. Ninety-eight percent of patients were extremely satisfied (77%) or somewhat satisfied (21%) with the program. Ninety-six percent of patients reported being involved in decisions about their care and treatments as well as high levels of understanding of medical information that was discussed during visit. Sixty-nine percent of patients reported that they shared the encounter form with their families and friends. Patients' self-confidence in communicating with their doctors increased from a score of 8.1 to 8.7 post-intervention (P-value = 0.0018). When comparing pre- and post-intervention experiences, only 38% of patients felt that their problems and questions were adequately addressed by other physicians' pre-intervention, compared with 94% post-intervention. We introduced a program to enhance physician-patient communication and found that patients were highly satisfied, more informed and more actively involved in their care. This approach may be an easily generalizable approach to improving physician-patient communication at outpatient visits.International Journal for Quality in Health Care 12/2011; 24(4):357-64. · 1.79 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Primary sclerosing cholangitis (PSC) is characterised by progressive inflammatory and fibrotic destruction of the biliary ducts. There are no effective medical therapies and presently high dose ursodeoxycholic acid is no longer recommended due to significant adverse events in a recent clinical trial. Cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction is associated with PSC in both children and adults. Since CFTR dysfunction leads to altered fatty acid metabolism, specifically reduced docosahexaenoic acid (DHA), we hypothesised that DHA supplementation might be an effective therapy for patients with PSC. To determine the safety and efficacy of oral DHA supplementation for the treatment of PSC. We conducted a 12 month open-label pilot study to evaluate safety of oral DHA and its effects on serum alkaline phosphatase as a primary outcome measure in 23 patients with PSC. DHA was administered orally at 800 mg twice per day. Secondary outcomes included changes in other liver function tests and fibrosis biomarkers. A 1.7-fold increase in serum DHA levels was observed with supplementation. The mean alkaline phosphatase level (±S.E.) at baseline was 357.8 ± 37.1 IU compared to 297.1 ± 23.7 IU (P < 0.05) after 12 months of treatment. There were no changes in other liver function tests and fibrosis biomarkers. No adverse events were reported. Oral DHA supplementation is associated with an increase in serum DHA levels and a significant decline in alkaline phosphatase levels in patients with PSC. These data support the need for a rigorous trial of DHA therapy in PSC.Alimentary Pharmacology & Therapeutics 11/2011; 35(2):255-65. · 4.55 Impact Factor - Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society 08/2011; 11(1):72-3; author reply 74-75. · 3.19 Impact Factor
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ABSTRACT: To measure the changes in whole blood fatty acid levels in premature infants and evaluate associations between these changes and neonatal morbidities. This was a retrospective cohort study of 88 infants born at <30 weeks' gestation. Serial fatty acid profiles during the first postnatal month and infant outcomes, including chronic lung disease (CLD), retinopathy of prematurity, and late-onset sepsis, were analyzed. Regression modeling was applied to determine the association between fatty acid levels and neonatal morbidities. Docosahexaenoic acid (DHA) and arachidonic acid levels declined rapidly in the first postnatal week, with a concomitant increase in linoleic acid levels. Decreased DHA level was associated with an increased risk of CLD (OR, 2.5; 95% CI, 1.3-5.0). Decreased arachidonic acid level was associated with an increased risk of late-onset sepsis (hazard ratio, 1.4; 95% CI, 1.1-1.7). The balance of fatty acids was also a predictor of CLD and late-onset sepsis. An increased linoleic acid:DHA ratio was associated with an increased risk of CLD (OR, 8.6; 95% CI, 1.4-53.1) and late-onset sepsis (hazard ratio, 4.6; 95% CI, 1.5-14.1). Altered postnatal fatty acid levels in premature infants are associated with an increased risk of CLD and late-onset sepsis.The Journal of pediatrics 06/2011; 159(5):743-749.e1-2. · 4.02 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Chronic visceral pain is frequent, extremely debilitating, and generally resistant to pharmacological treatment. It has been shown that chronic visceral inflammation, through altered afferent visceral sensory input, leads to plastic changes in the central nervous system that ultimately sustain pain. Therefore approaches aiming at modulation of brain activity are attractive candidates to control visceral pain. Here we report findings of a phase II, sham-controlled clinical trial assessing the clinical effects and brain metabolic correlates of a 10-day course of daily sessions of slow-frequency, repetitive transcranial magnetic stimulation (rTMS) targeting the right secondary somatosensory cortex (SII) in patients with chronic pancreatitis and severe visceral pain. Our results show a significant reduction in pain after real rTMS that lasted for at least 3 weeks following treatment. These clinical changes were correlated with increases in glutamate and N-acetyl aspartate (NAA) levels--neurometabolites associated with cortical activity and brain damage--as measured by in vivo single-voxel proton magnetic resonance spectroscopy (1H-MRS). Adverse effects in the real rTMS group were mild and short-lasting. Our results support preliminary findings showing that modulation of right SII with rTMS is associated with a significant analgesic effect and that this effect is correlated with an increase in excitatory neurotransmitter levels such as glutamate and NAA.European journal of pain (London, England) 01/2011; 15(1):53-60. · 3.37 Impact Factor -
Conference Paper: Size, Charge, and Affinity Fractionation of Hemolyzed Sera From a Neonatal Repository
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ABSTRACT: Hemolysis of serum or plasma can exclude very valuable samples from longitudinal studies, particular over time course, and risks the loss of valuable data. In human sera, the concentration of albumin is nearly ten billion times greater than that of cell-signaling proteins like the interleukins. The relative proportions of such rare, but extremely important biomarkers is further decreased in hemolyzed samples in which hemogloblin may nearly double the total protein concentration. Further, hemogloblin removal alone does not significantly decrease sample complexity. Sample prefractionation ideally partitions high abundance proteins like albumin, IgG, and hemoglobin into fractions separate from those containing the protein(s) of interest, potentially enabling enrichment and increasing the sensitivity of downstream microassays attempting to quantify these critical molecules. Samples from a neonatal depository are hoped to provide valuable information on pro-inflammatory response during the first days of life. However, such samples are extremely rare and frequently hemolyzed. To derive meaningful data from hemolyzed whole bloods and sera, fractionation schemes based of protein molecular mass, charge, or affinity were investigated as means of hemoglobin depletion with concomitant biomarker enrichment. Size separations were performed by sequential ultrafiltration with decreasing molecular weight cutoffs (MWCOs) to produce distinct size fractions, or by electrophoresis in the GELFREE System. Charge fractions were evaluated in the OFFGEL Fractionator or a Digital Protein Chip (dPC) capable of producing fractions of 0.05 pI unit intervals as well as pH specific column binding and elution. For affinity based separations, The ProteoMiner immobilized hexapeptide ligand library was used to isolate low abundance proteins without requiring prior hemoglobin depletion.2010 AIChE Annual Meeting; 11/2010 - [Show abstract] [Hide abstract]
ABSTRACT: Cystic fibrosis (CF) patients display a fatty acid imbalance characterized by low linoleic acid levels and variable changes in arachidonic acid. This led to the recommendation that CF patients consume a high-fat diet containing >6% linoleic acid. We hypothesized that increased conversion of linoleic acid to arachidonic acid in CF leads to increased levels of arachidonate-derived proinflammatory metabolites and that this process is exacerbated by increasing linoleic acid levels in the diet. To test this hypothesis, we determined the effect of linoleic acid supplementation on downstream proinflammatory biomarkers in two CF models: 1) in vitro cell culture model using 16HBE14o(-) sense [wild-type (WT)] and antisense (CF) human airway epithelial cells; and 2) in an in vivo model using cftr(-/-) transgenic mice. Fatty acids were analyzed by gas chromatography-mass spectrometry (GC/MS), and IL-8 and eicosanoids were measured by ELISA. Neutrophils were quantified in bronchoalveolar lavage fluid from knockout mice following linoleic acid supplementation and exposure to aerosolized Pseudomonas LPS. Linoleic acid supplementation increased arachidonic acid levels in CF but not WT cells. IL-8, PGE(2), and PGF(2α) secretion were increased in CF compared with WT cells, with a further increase following linoleic acid supplementation. cftr(-/-) Mice supplemented with 100 mg of linoleic acid had increased arachidonic acid levels in lung tissue associated with increased neutrophil infiltration into the airway compared with control mice. These findings support the hypothesis that increasing linoleic acid levels in the setting of loss of cystic fibrosis transmembrane conductance regulator (CFTR) function leads to increased arachidonic acid levels and proinflammatory mediators.AJP Lung Cellular and Molecular Physiology 11/2010; 299(5):L599-606. · 3.52 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A new approach in the treatment of cystic fibrosis involves improving the function of mutant cystic fibrosis transmembrane conductance regulator (CFTR). VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro. We randomly assigned 39 adults with cystic fibrosis and at least one G551D-CFTR allele to receive oral VX-770 every 12 hours at a dose of 25, 75, or 150 mg or placebo for 14 days (in part 1 of the study) or VX-770 every 12 hours at a dose of 150 or 250 mg or placebo for 28 days (in part 2 of the study). At day 28, in the group of subjects who received 150 mg of VX-770, the median change in the nasal potential difference (in response to the administration of a chloride-free isoproterenol solution) from baseline was -3.5 mV (range, -8.3 to 0.5; P=0.02 for the within-subject comparison, P=0.13 vs. placebo), and the median change in the level of sweat chloride was -59.5 mmol per liter (range, -66.0 to -19.0; P=0.008 within-subject, P=0.02 vs. placebo). The median change from baseline in the percent of predicted forced expiratory volume in 1 second was 8.7% (range, 2.3 to 31.3; P=0.008 for the within-subject comparison, P=0.56 vs. placebo). None of the subjects withdrew from the study. Six severe adverse events occurred in two subjects (diffuse macular rash in one subject and five incidents of elevated blood and urine glucose levels in one subject with diabetes). All severe adverse events resolved without the discontinuation of VX-770. This study to evaluate the safety and adverse-event profile of VX-770 showed that VX-770 was associated with within-subject improvements in CFTR and lung function. These findings provide support for further studies of pharmacologic potentiation of CFTR as a means to treat cystic fibrosis. (Funded by Vertex Pharmaceuticals and others; ClinicalTrials.gov number, NCT00457821.).New England Journal of Medicine 11/2010; 363(21):1991-2003. · 54.42 Impact Factor
Publication Stats
4k | Citations | |
863.56 | Total Impact Points | |
Top Journals
Beth Israel Deaconess Medical Center
- • Division of Gastroenterology
- • Department of Neonatology
- • Pancreas Center
- • Department of Medicine
- • Department of Obstetrics and Gynecology
- • Department of Surgery
Boston, Massachusetts, United States
Harvard Medical School
Boston, Massachusetts, United States
University of California, San Francisco
- Division of Hospital Medicine
San Francisco, CA, United States -
Sydney Children's Hospital
Sydney, New South Wales, Australia
Toronto, Ontario, Canada
Universidade Presbiteriana Mackenzie
- Centro de Ciências Biológicas e da Saúde (CCBS)
São Paulo, Estado de Sao Paulo, Brazil
Massachusetts General Hospital
- Department of Pathology
Boston, MA, United States -
University of Toronto
- Hospital for Sick Children
Toronto, Ontario, Canada
Boston Children's Hospital
Boston, Massachusetts, United States
University of Cincinnati
- Division of Digestive Diseases
Cincinnati, OH, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States


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Dr. Suzanne B. Smith-elekes, DO
Infectious Disease
- 7900 W Jefferson Blvd Ste 201
Fort Wayne, IN 46804 - 1 Location
- (260) 432-2297
Dr. Suzanne B. Smith-elekes graduated from the Philadelphia College of Osteopathic Medicine in 1988. She works in Fort Wayne, IN and specializes in Infectious Disease. Dr. Smith-elekes is affiliated with Dupont Hospital, Lutheran Hospital Of Indiana and Paulding County Hospital. She speaks English and Spanish.
Gender: Female
Languages Spoken: English, Spanish
Infectious Disease
Medical School: Philadelphia College of Osteopathic Medicine; Graduated 1988
7900 W Jefferson Blvd Ste 201
Fort Wayne, IN 46804
(260) 432-2297