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Comedian Finesse Mitchell Talks About His Latest Project
Description:He is most famous for his stint on 'Saturday Night Live', but Finesse Mitchell can be found all over the television screen. He talks about his latest projects, and his new standup show in Chicago. (4:54)
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Publications (43)317.5 Total impact
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ABSTRACT: Background: Biomarker-driven clinical trials in advanced non-small cell lung cancer (NSCLC) usually accept biopsy specimens only, as cytology specimens are supposed to be more challenging due to low neoplastic cell content and suboptimal DNA quantity. Objectives: We aimed to evaluate 2 aspects of bronchoscopic biopsy and cytology specimens: (1) the proportion of neoplastic cells and quantity of DNA extracted, and (2) the detection limit of the Scorpion amplification refractory mutation system on endoscopic samples obtained in daily clinical practice. Methods: We screened 679 patients with advanced-stage NSCLC for the presence of an activating EGFR mutation according to the guidelines of the European Society of Medical Oncology. Their diagnostic tumour tissue samples were characterized. A dilution experiment was performed to determine the minimal proportion of neoplastic cells for a reliable test result. Results: Surgical biopsies, bronchoscopic forceps biopsy samples and needle aspiration cytology specimens exhibited a median tumour cell proportion of 70 versus 30 versus 20% and a DNA quantity of 2,500 versus 1,610 versus 1,440 ng, respectively. The overall EGFR mutation rate was 11%, with no differences between different sample types. Dilution experiments showed that the detection limit depends on the type of mutation. A neoplastic cell content of at least 10 and 25% for exon 19 deletions and exon 21 L858R point mutation, respectively, was required for a true negative result. Conclusions: Bronchoscopic forceps biopsy and needle aspiration cytology specimens are suitable for accurate EGFR mutation analysis using single-gene quantitative real-time polymerase chain reaction. Technologies with a better analytical sensitivity are evolving and should consider these endoscopic tumour specimens. © 2014 S. Karger AG, Basel.Respiration 10/2014; 88(5). · 2.92 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The main challenge in CT screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Management protocols use thresholds for nodule size and growth rate to determine which nodules require additional diagnostic procedures, but these should be based on individuals' probabilities of developing lung cancer. In this prespecified analysis, using data from the NELSON CT screening trial, we aimed to quantify how nodule diameter, volume, and volume doubling time affect the probability of developing lung cancer within 2 years of a CT scan, and to propose and evaluate thresholds for management protocols.The Lancet Oncology 10/2014; · 24.73 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Low-dose CT screening is recommended for individuals at high risk of developing lung cancer. However, CT screening does not detect all lung cancers: some might be missed at screening, and others can develop in the interval between screens. The NELSON trial is a randomised trial to assess the effect of screening with increasing screening intervals on lung cancer mortality. In this prespecified analysis, we aimed to assess screening test performance, and the epidemiological, radiological, and clinical characteristics of interval cancers in NELSON trial participants assigned to the screening group.The Lancet Oncology 10/2014; · 24.73 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Purpose To evaluate the diagnostic accuracy of the visual assessment of malignant pleural mesothelioma (MPM) on magnetic resonance (MR) images by using two known visual markers (mediastinal pleural thickness and shrinking of the lung) and a newly introduced one (pleural pointillism). Materials and Methods With the approval of the local ethics committee, 100 consecutive patients (mean age, 61.4 years; age range, 18-87 years; 75 men, 25 women) suspected of having MPM pleural abnormalities underwent positron emission tomography/computed tomography and MR imaging, including diffusion-weighted (DW) MR imaging, followed by explorative thoracoscopy or guided biopsy with histopathologic confirmation. Because visual assessment is still the preferred method of image interpretation, the diagnostic accuracy of mediastinal pleural thickening, shrinking lung (hemithorax volume decrease due to fibrosis), and pleural pointillism were examined. Pleural pointillism was denoted by the presence of multiple, hyperintense pleural spots on high-b-value DW images. Histopathologic findings in the surgical specimen served as the reference standard. McNemar tests with Bonferroni correction were used to assess differences in accuracy among the three examined markers. Results Of 100 patients, 33 had benign pleural alterations, and 67 had malignant pleural diseases (MPDs); 57 of 67 had MPM. A total of 78 patients received a correct diagnosis (benign vs malignant) on the basis of mediastinal pleural thickening (sensitivity, 81%; specificity, 73%; accuracy, 78%); and 66 patients, on the basis of shrinking lung (sensitivity, 60%; specificity, 79%; accuracy, 66%). The correct diagnosis was indicated on the basis of pleural pointillism in 88 patients (sensitivity, 93%; specificity, 79%; accuracy, 88%). Conclusion Visual assessment of pleural pointillism on high-b-value DW images is useful to differentiate MPD from benign alterations, performing substantially better than mediastinal pleural thickness and shrinking lung, and might obviate unnecessary invasive procedures for MPM. © RSNA, 2014.Radiology 09/2014; · 6.21 Impact Factor - American Journal of Respiratory and Critical Care Medicine 08/2014; 190(4):e12-3. · 11.04 Impact Factor
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ABSTRACT: Past and present asbestos use will reflect in increasing numbers of mesothelioma cases in the next decades, diagnosed at a late stage and with a dismal prognosis. This stresses the need for early detection tools which could improve patient's survival. Recently, breath analysis as a non-invasive and fast diagnostic tool has found its way into biomedical research. High-throughput breathomics uses spectrometric, chromatographic and sensor techniques to diagnose asbestos-related pulmonary diseases based upon volatile organic compounds (VOCs) in breath. This article reviews the state-of-the-art available breath analyzing techniques and provides the insight in the current use of VOCs as early diagnostic or prognostic biomarkers of mesothelioma in order to stimulate further research in this field.Cancer Epidemiology Biomarkers & Prevention 04/2014; · 4.56 Impact Factor -
Conference Paper: Lung Cancer Probability in Subjects with CT-detected Pulmonary Nodules
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ABSTRACT: PURPOSE The main challenge in computed tomography (CT) screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Thresholds for nodule size and growth rate, which determine which nodules require additional diagnostic measures, should be based on the lung cancer probability of the individual. METHOD AND MATERIALS The diameter, volume and volume-doubling time (VDT) of 9,681 non-calcified nodules detected in 7,135 participants in the Dutch-Belgian lung cancer screening trial were used to quantify their lung cancer probability. Complete coverage on all lung cancer diagnoses was obtained by linkages with the national cancer registry, for a follow-up of eight years. The probabilities were used to propose and evaluate optimized thresholds for CT-detected nodules. RESULTS Lung cancer probability was low in subjects with a nodule volume <100mm³ (≤0.7%) or maximum transverse diameter <5mm (≤0.5%). Moreover, probability in these subjects was not significantly different from that in subjects without nodules (0.4%). Lung cancer probability was intermediate for nodule volumes 100-300mm³ (1.5-5.8%) and diameters 5-10mm (0.9-2.9%); the VDT further stratified the probability: 0.0-0.9% for VDTs>600days, 4.0% for VDTs 400-600days and 6.7-25.0% for VDTs<400days. Lung cancer probability was high for participants with nodule volumes ≥300mm³ (8.9-26.1%) or diameters ≥10mm (11.1-26.2%), even with long VDTs. CONCLUSION Subjects with nodules <100mm³ or <5mm have a lung cancer risk that is not significantly different from that in subjects without nodules and do not require additional evaluation. Individuals with nodules 100-300mm³ or 5-10mm represent an indeterminate subgroup for whom the assessment of VDT is appropriate (<400days warrants diagnostic work-up). However, the risk for subjects with nodules ≥300mm³ or ≥10mm demands immediate diagnostic evaluation. CLINICAL RELEVANCE/APPLICATION This study provides detailed and reliable data on the lung cancer probability of subjects with CT-detected nodules stratified by nodule diameter, volume and growth rate. This information can be valuabRadiological Society of North America 2013 Scientific Assembly and Annual Meeting; 12/2013 - [Show abstract] [Hide abstract]
ABSTRACT: To evaluate the diagnostic accuracy of dynamic contrast-enhanced (DCE) magnetic resonance (MR) and diffusion-weighted imaging (DWI) sequences for defining benignity or malignancy of solitary pulmonary lesions (SPL). First, 54 consecutive patients with SPL, clinically staged (CT and PET or integrated PET-CT) as N0M0, were included in this prospective study. An additional 3-Tesla MR examination including DCE and DWI was performed 1 day before the surgical procedure. Histopathology of the surgical specimen served as the standard of reference. Subsequently, this functional method of SPL characterisation was validated with a second cohort of 54 patients. In the feasibility group, 11 benign and 43 malignant SPL were included. Using the combination of conventional MR sequences with visual interpretation of DCE-MR curves resulted in a sensitivity, specificity and accuracy of 100 %, 55 % and 91 %, respectively. These results can be improved by DWI (with a cut-off value of 1.52 × 10(-3) mm(2)/s for ADChigh) leading to a sensitivity, specificity and accuracy of 98 %, 82 % and 94 %, respectively. In the validation group these results were confirmed. Visual DCE-MR-based curve interpretation can be used for initial differentiation of benign from malignant SPL, while additional quantitative DWI-based interpretation can further improve the specificity. • Magnetic resonance imaging is increasingly being used to help differentiate lung lesions. • Solitary pulmonary lesions (SPL) are accurately characterised by combining DCE-MRI and DWI. • Visual DCE-MRI assessment facilitates the diagnostic throughput in patients with SPL. • DWI provides additional information in inconclusive DCE-MRI (type B pattern).European Radiology 10/2013; · 4.34 Impact Factor -
Article: Low-dose computed tomography screening for lung cancer: results of the first screening round.
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ABSTRACT: Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose computed tomography (LDCT) screening rather than chest x-ray (CXR) screening. This paper from the US NLST research team focuses on the results of the initial round of LDCT for lung cancer. A total of 53,439 participants were included and randomly assigned to LDCT screening (n = 26,715) or CXR screening (n = 26,724). In total, 27.3% of the participants in the LDCT group and 9.2% in the CXR group had a positive screening result. As a result, 3.8% (LDCT group) and 5.7% (CXR group) of these subjects were diagnosed with lung cancer. The sensitivity (93.8%) and specificity (73.4%) for lung cancer were higher for LDCT compared with CXR screening; 73.5 and 91.3%, respectively.Journal of comparative effectiveness research. 09/2013; 2(5):433-6. -
Article: Large-bore nitinol stents for malignant superior vena cava syndrome: factors influencing outcome.
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ABSTRACT: OBJECTIVE. The purpose of this article is to retrospectively evaluate the technical and clinical outcomes of large-bore nitinol stents for treating malignant superior vena cava syndrome. In addition, we analyzed factors potentially influencing the outcome. MATERIALS AND METHODS. Over a 7-year period, 78 consecutive patients presented with superior vena cava syndrome related to primary lung tumor (n = 62) or malignant lymphadenopathies (n = 16). The factors analyzed were Kishi score at admission, tumor type, and need for an additional balloon-expandable stent. RESULTS. Technical success was obtained in all but one patient (99%), who presented with a stent migration immediately after insertion. In 17 patients (22%), an additional balloon-expandable stent was needed for complete expansion of the nitinol stent. For patients with symptomatic malignant lymphadenopathies or primary lung tumor, overall survival rates were 50% (n = 8) and 54% (n = 34), respectively, at 6 months and 19% (n = 3) and 34% (n = 21), respectively, at 12 months (p = 0.376). There was no difference in survival as a function of the Kishi score (p = 0.80) or of the placement of an additional balloon-expandable stent (p = 0.35). Finally, reocclusion events were noted in patients both with (n = 1) and without (n = 7) a balloon-expandable stent. CONCLUSION. Large-bore nitinol stents are highly effective for malignant superior vena cava syndrome. The survival rates of patients with caval vein stenosis due to either the primary tumor or secondary enlarged adenopathies were equal. An additional balloon-expandable stent was required in 22% of cases owing to incomplete expansion of the nitinol stent but was not associated with higher thrombosis rate.American Journal of Roentgenology 09/2013; 201(3):667-74. · 2.74 Impact Factor -
Article: Volumetric computer tomography screening for lung cancer: three rounds of the NELSON trial.
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ABSTRACT: Several medical associations recommended lung cancer screening by low-dose computer tomography (LDCT) scanning for high-risk groups. Counselling of the candidates on the potential harms and benefits and their lung cancer risk is a prerequisite for screening.In the NELSON trial, screenings are considered positive for (part) solid lung nodules with a volume >500 mm(3) and for (part) solid or non-solid nodules with a volume-doubling time <400days. For this study, the performance of the NELSON strategy in three screening rounds was evaluated and risk calculations were made for a follow-up period of 5.5 years.458 (6%) of the 7.582 screened participants had a positive screen result and 200 (2.6%) were diagnosed with lung cancer. The positive screenings had a predictive value of 40.6% and only 1.2% of all scan results were false-positive. In a period of 5.5 years, the risk of screen-detected lung cancer strongly depends on the result of the first scan: 1.0% after a negative baseline result, 5.7% after an indeterminate baseline and 48.3% after a positive baseline.The screening strategy yielded few positive and false-positive scans with a reasonable positive predictive value. The 5.5-year lung cancer risk calculations aid clinicians in counselling candidates for lung cancer screening with LDCT.European Respiratory Journal 07/2013; · 7.13 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: RATIONALE: The NELSON trial is with 15,822 participants the largest European lung cancer computer tomography screening trial. A volumetry-based screening strategy, stringent criteria for a positive screening and an increasing length of the screening interval are particular features of the NELSON trial. OBJECTIVES: To determine the effect of stringent referral criteria and increasing screening interval on the characteristics of the screen-detected lung cancers, and to compare this across screening rounds, between genders and with other screening trials METHODS: All NELSON participants with screen-detected lung cancer in the first three rounds were included. Lung cancer stage at diagnosis, histological subtype, and tumor localization were compared between the screening rounds, the genders and with other screening trials. MEASUREMENTS AND MAIN RESULTS: In the first three screening rounds, 200 participants were diagnosed with 209 lung cancers. 70.8% of the lung cancers were diagnosed at stage I, 8.1% at stage IIIB-IV and 51.2% were adenocarcinomas. There was no significant difference in cancer stage, histology or tumor localization across the screening rounds. Women were diagnosed at a significantly more favorable cancer stage than men. Compared to other trials, the screen-detected lung cancers of the NELSON trial were relatively more often diagnosed at stage I and less often at stage IIIB-IV. CONCLUSIONS: Despite stringent criteria for a positive screening, an increasing length of the screening interval and few female participants, the screening strategy of the NELSON trial resulted in a favorable cancer stage distribution at diagnosis, which is a prerequisite for the effectiveness of our screening strategy.American Journal of Respiratory and Critical Care Medicine 01/2013; · 11.04 Impact Factor -
Conference Paper: High Accuracy for Preoperative Pulmonary Lesion Characterization Using the Interpreting Combination of Visual Perfusion and Quantitative Diffusion MR Imaging
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ABSTRACT: PURPOSE To evaluate the diagnostic accuracy of dynamic contrast enhanced (DCE) magnetic resonance (MR) and diffusion weighted imaging (DWI) sequences for diagnosing of preoperative pulmonary nodules and masses. A simplified MR examination evaluation may lead to a better characterization of lung lesions. METHOD AND MATERIALS Sixty consecutive preoperative patients aged 61.3 ± 29.3 years (39 males and 21 females) and staged on PET/CT as N0M0 were included in this prospective study. We performed an additional MR including diffusion- and perfusion-weighted imaging one day before the surgical procedure. PET/CT staging occurred in the clinical routine patient diagnosis and only if integrated PET-CT available (22/60 in 45%), for study purposes each lesion was quantitatively measured by a contrast ratio of maximal standard uptake value (SUVmax-CR) between the lesion and the contralateral lung. All MR images were interpreted independently by 2 experienced radiologists. Afterwards they were evaluated in consensus and an interpreting flowchart was distillated based on statistical principles. Histopathology of the surgical specimen served as standard of reference. RESULTS Sixty-six lung lesions in this cohort -17 benign and 49 malignant lung nodules/masses- had a diameter that varied from 3 to 62 mm (mean 16.2 mm). Only two lesions on DWI could not be determined, because of high noise level. The sensitivity, specificity and accuracy of PET/CT are 87.0%, 31.3% and 74.3%. Using the conventional MR sequences with visual interpretation of DCE-MR curves gives 96.3%, 68,8% and 90.0%. This can be augmented by additional interpretation of quantitiative ADC values (with a cut-off value of 1.52 x10^(-3) mm²/s of ADCaverage and 1.3 x10^(-3) mm²/s of ADChigh) leading to 96.3%, 100% and 97.1% respectively. CONCLUSION Visual DCE-MR based curve interpretation can be used as first separation of benign from malignant lesions, while further quantitiative DWI-based interpretation can lead to a higher accuracy. CLINICAL RELEVANCE/APPLICATION DCE-MRI and DWI might help to provide a more accurate diagnosis in preoperative patients suspected for malignant pulmonary nodules and masses avoiding invasive procedures or follow-up examinations.Radiological Society of North America 2012 Scientific Assembly and Annual Meeting; 11/2012 -
Article: Maintenance therapy for advanced non-small-cell lung cancer: a pilot study on patients' perceptions.
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ABSTRACT: Several randomized trials on maintenance therapy (MT) for metastatic non-small-cell lung cancer (NSCLC) have demonstrated benefit in progression-free survival. More recently, a study with pemetrexed and one with erlotinib also showed significant gains in overall survival (OS). Yet, in this palliative treatment setting, the benefit has to be weighed against the potential burden of treatment, and thus patients' preferences should be taken into account. In the absence of data on this topic, we undertook a pilot survey with 10 questions covering the overall patient attitude toward MT, the benefit expected by patients, and the acceptance of side effects or modes of administration. Included patients had stage IV NSCLC and were planned to start first-line platinum-based doublet chemotherapy. The questionnaire was submitted at the start of and after two and four cycles of chemotherapy. Thirty patients were included. Overall, patients had a positive attitude toward MT. At baseline, it was considered worthwhile by 83%, 67%, and 43% of patients for an OS benefit of 6, 3, or 1 month, respectively, with some decrease over time. Effects on symptom control were crucial for about 90% of the patients. There was a slight preference for oral versus intravenous administration. Side effects were accepted by most patients as long as they were mild to moderate. Our pilot survey showed that metastatic NSCLC patients in general are in favor of MT. They expect either an OS benefit of at least several months, or better symptom control, in balance with mild-to-moderate side effects.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 05/2012; 7(8):1291-5. · 4.55 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To investigate the use of diffusion-weighted (DW) imaging for differentiating benign lesions from malignant pleural disease (MPD) and to retrospectively assess dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging acquisitions to find out whether combining these measurements with DW imaging could improve the diagnostic value of DW imaging. This study was approved by the local ethics committee, and all patients provided written informed consent. Thirty-one consecutive patients with pleural abnormalities suspicious for MPD underwent whole-body positron emission tomography (PET)/computed tomography (CT) and thorax MR examinations. Diagnostic thoracoscopy with histopathologic analysis of pleural biopsies served as the reference standard. First-line evaluation of each suspicious lesion was performed by using the apparent diffusion coefficient (ADC) calculated from the DW image, and the optimal cutoff value was found by using receiver operating characteristic curve analysis. Afterward, DCE MR imaging data were used to improve the diagnosis in the range of ADCs where DW imaging results were equivocal. Sensitivity, specificity, and accuracy of PET/CT for diagnosis of MPD were 100%, 35.3%, and 64.5%. The optimal ADC threshold to differentiate benign lesions from MPD with DW MR imaging was 1.52 × 10(-3) mm(2)/sec, with sensitivity, specificity, and accuracy of 71.4%, 100%, and 87.1%, respectively. This result could be improved to 92.8%, 94.1%, and 93.5%, respectively, when DCE MR imaging data were included in those cases where ADC was between 1.52 and 2.00 × 10(-3) mm(2)/sec. A total of 20 patients had disease diagnosed correctly, nine had disease diagnosed incorrectly, and two cases were undetermined with PET/CT. DW imaging helped stage disease correctly in 27 patients and incorrectly in four. The undetermined cases at PET/CT were correctly diagnosed at MR imaging. DW imaging is a promising tool for differentiating MPD from benign lesions, with high accuracy, and supplementation with DCE MR imaging seems to further improve sensitivity.Radiology 04/2012; 263(3):884-92. · 6.21 Impact Factor -
Article: Complications following lung surgery in the Dutch-Belgian randomized lung cancer screening trial.
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ABSTRACT: To assess the complication rate in participants of the screen arm of the NELSON lung cancer screening trial who underwent surgical resection and to investigate, based on a literature review, whether the complication rate, length of hospital stay, re-thoracotomy and mortality rates after a surgical procedure were different from those of the non-screening series, taking co-morbidity into account. Between April 2004 and December 2008, 198 subjects underwent thoracic surgery. Co-morbid conditions were retrieved from the medical records. Postoperative complications were classified as minor and major. In total, 182 thoracotomies, 5 thoracotomies after video-assisted thoracoscopic surgery (VATS) and 11 VATS procedures were performed. In these patients, 36% had chronic obstructive lung disease, 16% coronary artery disease, 14% diabetes mellitus and 11% peripheral vascular disease. Following thoracotomy, 47% (88/187) had ≥1 minor (7-57% in literature) and 10% (18/187) ≥1 major complication (2-26% in literature); following VATS, 38% (6/16) had ≥1 minor complication, but no major complications. Seventeen per cent (3/18) of major complications and 21% (20/96) of minor complications were seen in subjects operated for benign disease. The re-thoracotomy rate was 3% and there was no 30-day mortality after thoracotomy or VATS (0-8.3% in literature). The mortality rate of 0% after surgical procedures is low when compared with the non-screening series (0-8.3%); the rate of complications (53%) is within range when compared with the non-screening series (8.5-58%). In conclusion, mortality rates after surgical procedures are lower in the NELSON lung cancer screening trial than those in the non-screening series. The rate of complications is within the same range as in the non-screening series. Trial registration number: ISR CTN 63545820.European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 04/2012; 42(3):420-9. · 2.40 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Mesothelin is currently considered the best available serum biomarker of malignant pleural mesothelioma. To examine the diagnostic accuracy and use of serum mesothelin in early diagnosis, we performed an individual patient data (IPD) meta-analysis. The literature search identified 16 diagnostic studies of serum mesothelin, measured with the Mesomark enzyme-linked immunosorbent assay. IPD of 4,491 individuals were collected, including several control groups and 1,026 patients with malignant pleural mesothelioma. Mesothelin levels were standardized for between-study differences and age, after which the diagnostic accuracy and the factors affecting it were examined with receiver operating characteristic (ROC) regression analysis. At a common diagnostic threshold of 2.00 nmol/L, the sensitivities and specificities of mesothelin in the different studies ranged widely from 19% to 68% and 88% to 100%, respectively. This heterogeneity can be explained by differences in study population, because type of control group, mesothelioma stage, and histologic subtype significantly affected the diagnostic accuracy. The use of mesothelin in early diagnosis was evaluated by differentiating 217 patients with stage I or II epithelioid and biphasic mesothelioma from 1,612 symptomatic or high-risk controls. The resulting area under the ROC curve was 0.77 (95% CI, 0.73 to 0.81). At 95% specificity, mesothelin displayed a sensitivity of 32% (95% CI, 26% to 40%). In patients suspected of having mesothelioma, a positive blood test for mesothelin at a high-specificity threshold is a strong incentive to urge further diagnostic steps. However, the poor sensitivity of mesothelin clearly limits its added value to early diagnosis and emphasizes the need for further biomarker research.Journal of Clinical Oncology 03/2012; 30(13):1541-9. · 17.88 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Up to 50% of the participants in CT scan lung cancer screening trials have at least one pulmonary nodule. To date, the role of conventional bronchoscopy in the workup of suspicious screen-detected pulmonary nodules is unknown. If a bronchoscopic evaluation could be eliminated, the cost-effectiveness of a screening program could be enhanced and the potential harms of bronchoscopy avoided. All consecutive participants with a positive result on a CT scan lung cancer screening between April 2004 and December 2008 were enrolled. The diagnostic sensitivity and negative predictive value were calculated at the level of the suspicious nodules. In 95% of the nodules, the gold standard for the outcome of the bronchoscopy was based on surgical resection specimens. A total of 318 suspicious lesions were evaluated by bronchoscopy in 308 participants. The mean ± SD diameter of the nodules was 14.6 ± 8.7 mm, whereas only 2.8% of nodules were > 30 mm in diameter. The sensitivity of bronchoscopy was 13.5% (95% CI, 9.0%-19.6%); the specificity, 100%; the positive predictive value, 100%; and the negative predictive value, 47.6% (95% CI, 41.8%-53.5%). Of all cancers detected, 1% were detected by bronchoscopy only and were retrospectively invisible on both low-dose CT scan and CT scan with IV contrast. Conventional white-light bronchoscopy should not be routinely recommended for patients with positive test results in a lung cancer screening program.Chest 02/2012; 142(2):377-84. · 7.13 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: In patients with lung cancer, bone is one of the most frequent sites of distant spread, with approximately 30% of patients developing skeletal metastases. About half of these patients will experience a skeletal-related event, the occurrence of which not only affects quality of life, but is also associated with poor prognosis. Bisphosphonates are currently the mainstay for treating bone metastases in patients with lung cancer, with proven beneficial effects on prevention and delay of skeletal complications. Their role in preventing the development of skeletal metastases, their anti-tumoral properties and their effect on survival remain to be elucidated. Other bone-targeted therapies are being investigated in phase II and III clinical trials and might expand the therapeutic arsenal in the near future.Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 01/2012; 192:93-108. - Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 12/2011; 6(12):2143-4; author reply 2144-5. · 4.55 Impact Factor
Publication Stats
991 | Citations | |
317.50 | Total Impact Points | |
Top Journals
Universitair Ziekenhuis Leuven
- Department of Radiology
Louvain, Flanders, Belgium
Erasmus Universiteit Rotterdam
- Department of Public Health (MGZ)
Rotterdam, South Holland, Netherlands
Erasmus MC
- • Research Group for Public Health
- • Department of Public Health
Rotterdam, South Holland, Netherlands
Medical University of Vienna
Wien, Vienna, Austria
Universitair Ziekenhuis Ghent
Gand, Flanders, Belgium
University of Leuven
Louvain, Flanders, Belgium

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Volunteering as a youth soccer coach can be a great experience for you and your squad. But what if you've never coached before? Don't worry! This friendly guide offers expert advice on evaluating your players, running drills that make practices fun, and coaching offense and defense.
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When four teams folded after the Basketball Association of America's first season, the surviving seven clubs were desperate for competition. So they pulled a minor league team, Baltimore, into the fold to "round out" the divisions.
In all fairness, it should be pointed out that although the Bullets were a minor league team prior to joining the BAA, they were the ultimate minor league team. They had won four consecutive titles in the old American League during the 1940s. Bullets owner Robert "Jake" Embry and Bill Dyer, a local sports broadcaster who managed the team, aspired to build the Bullets into a big-league franchise. They had wanted to join the BAA in its first year, but the new league had balked because of the Bullets' shoddy building, the old Coliseum on North Monroe Street in one of Baltimore's poorer neighborhoods.
The key to the team's success was player-coach Buddy Jeannette, whom Dyer had lured away from the NBL's Fort Wayne Pistons, a team that Jeannette and Bobby McDermott had led to back-to-back league championships. Having Jeannette, an NBL star, on the roster also helped Baltimore impress the BAA. The new league needed all the stars it could get.
When the BAA finally called in 1947, the Bullets were ready and willing, even if the conditions weren't ideal. Their addition made for an awkward alignment. Philadelphia, Boston, Providence and New York played in the Eastern Division; Washington and Baltimore joined Chicago and St. Louis in the Western. The Bullets, however, were just happy to be in the circuit, tenuous as it was.
Only good basketball teams draw such affection, and the Bullets were very good. At the core of the roster as the season opened were 5-foot-11 guard Jeannette and 6-foot-6 forward Mike Bloom, a two-time MVP of the old ABL. At age 33, Bloom had a little mileage on him, but he still had a deadly set shot and a nose for defense that made him a crowd favorite.
In an era before the development of the fully athletic big man, basketball was a guard-dominated game. So right before the season, the Bullets loaded up some extra ammunition by signing another veteran guard, Joseph Francis "Chick" Reiser, away from the NBL's Pistons. He was one of the premier set shooters in that age of two-handed, long-range gunners, and he boosted the Bullets' offense by averaging 11.5 points that season.
Baltimore promptly swept the Chicago Stags in two games and then faced the Philadelphia Warriors, who had survived a grueling seven-game series with St. Louis. If anything, the Warriors had strengthened their team from the previous season with the addition of center Chuck Halbert from Chicago. Their lineup was impressive, even if their regular-season record wasn't.
"When you have [Joe] Fulks and Halbert and [Howie] Dallmar under the basket and [George] Senesky outside, you've got a pretty good ballclub," said Baltimore's Paul Hoffman.
Having taken the division title, the Warriors also had the home-court advantage, despite their slightly inferior record. (Baltimore was 28-20 in the regular season; Philadelphia was 27-21). "We knew we had to win at least one game in Philadelphia," Jeannette said. That didn't happen in Game 1, however, as Philadelphia won 71-60 before a less-than-capacity crowd of 7,201.
Then things got worse for the Bullets. In Game 2, Philadelphia rolled out to a 41-20 halftime lead. "In those days, if you got behind that far, the game was over," Jeannette said. "There was no 24-second clock to help you come back. But somehow we did. We took our time and made our shots and caught 'em. I don't know if we were so good or Philly was so bad."
Fulks helped matters by continuing to shoot -- and miss. And the Bullets helped themselves by driving to the basket for good shots. The home crowd sat stunned as the Bullets took a late lead. They cut the gap to 48-40 in the third quarter. Then, in the last period, it was all Baltimore. "We were up by one with four seconds to go, and I tipped in a missed free throw," Hoffman recalled.
The 66-63 victory was one of the more impressive comebacks in sports history. Unfortunately, nobody paid much attention to pro basketball then. The story received a few paragraphs on the back page of The New York Times. Still, it gave the Bullets the momentum they were looking for.
For their part, the Warriors had simply run out of energy. "What killed us was the seven-game series with St. Louis," Senesky said. "We had gone back and forth on the train, and it was a 24-hour trip. We could have flown and saved some energy if the weather had been better."
Baltimore took the two games at the Coliseum by scores of 72-70 and 78-75. Back in Philadelphia, the Warriors prevailed in Game 5, 91-82, but they still had to return to Baltimore for Game 6, trailing by a game. There, on April 21, the "minor leaguers" took the title with an 88-72 blowout.
The evening was nothing fancy -- just another good time at the neighborhood deli where the team always gathered. "There wasn't much celebration," Jeannette said. "None of that crap of shooting champagne over everybody. That was just another game to us."
The $2,000 in prize money helped make it a little more special. And Gunther Brewery, one of the team's sponsors, gave Jeannette a television set. The brewery gave each of the other players a pen and pencil set, a disparity that had the Bullets still hooting decades later.
There were none of the big endorsements and contract upgrades that today's superstars receive after a championship win. "But I wouldn't trade all of my experiences for any of their million-dollar contracts," said Jeannette fondly. "We were a good team. We won in every league we played in."


text:
Jeff co-founded the Weather Underground in 1995 while working on his Ph.D. He flew with the NOAA Hurricane Hunters from 1986-1990.
By: Dr. Jeff Masters , 1:47 PM GMT on June 02, 2010
A hellish heat wave hit Pakistan last week, sending the mercury to an astonishing 53.5°C (128.3°F) at the town of MohenjuDaro on Wednesday May 26, reported the Pakistani Meteorological Department. While this temperature reading must be reviewed by the World Meteorological Organization (WMO) for authenticity, not only is the 128.3°F reading the hottest temperature ever recorded in Pakistan, it is the hottest reliably measured temperature ever recorded on the continent of Asia. This information comes to me courtesy of Chris Burt, the author of Extreme Weather, who is probably the world's foremost expert on extreme weather records. In a collaborative effort with weather record researchers Maximiliano Herrera and Howard Rainford, Mr. Burt has painstakingly researched the extreme weather records for every country on Earth. They list the previous reliable record high for Asia as the 52.7°C (127°F) temperature measured on June 12, 1919, in the Sindh province of Pakistan. Temperatures exceed 120°F in this region of Pakistan nearly every year, in the late May/early June time frame before the monsoon arrives. Last week's heat wave killed at least 18 Pakistanis, and temperatures in excess of 50°C (122°F) were recorded at nine Pakistani cities on May 26, including 53°C (127.4°F) at Sibi.
All-time hottest temperature for Southeast Asia this month
Record heat also hit Southeast Asia in May. According to the Myanmar Department of Meteorology and Hydrology, Myanmar (Burma) had its hottest temperature in its recorded history on May 12, when the mercury hit 47°C (116.6°F) in Myinmu. Myanmar's previous hottest temperature was 45.8°C (114.4°F) at Minbu, Magwe division on May 9, 1998. According to Mr. Burt, the 47°C (116.6°F) measured on May 12 this year is the hottest temperature measured in Southeast Asia in recorded history.
Bogus extreme temperature records
I'm pleased to say that Chris Burt will be joining wunderground.com as a featured blogger later this year to discuss his work. He's working on a great new website that features weather records for each country of the world, complete with footnotes on disputed records. For example, many record books list Israel as the site of Asia's all-time maximum temperature. Mr. Burt comments: "54°C (129.2°F) has widely been quoted as the highest temperature ever recorded in Israel (and Asia) but there exist serious issues with this record. The temperature was recorded on a thermograph at Tirat Zvi on 21 June 1942. Examination of a copy of this trace (see Bio-Climatic Atlas of Israel by Dr. D. Ashbel, Central Press, Jerusalem, 1950, p.125, Figure 1) actually shows a maximum temperature of 53°C (127.4°F). No explanation is known for this 1°C discrepancy. In comparison with surrounding stations, it is likely that the actual temperature recorded at Tirat Zvi on this data was probably no higher than 52°C (125.6°F), which would be a record high temperature for Israel. Temperatures have reached or exceeded 50°C (122°F) in Israel only during this one episode in 1942.
Figure 1. Temperature trace from Bio-Climatic Atlas of Israel by Dr. D. Ashbel, Central Press, Jerusalem, 1950, p.125 for Tirat Zvi, Israel, the week of June 21, 1942.
Figure 2. Zoom of temperature trace from Bio-Climatic Atlas of Israel by Dr. D. Ashbel, Central Press, Jerusalem, 1950, p.125, for Tirat Zvi, Israel, the week of June 21, 1942. The temperature clearly only reached 53°C, if one reads the graph properly. Thus the 54°C temperature labeled on the graph is not correct.
Mr. Burt comments in his Extreme Weather book that every temperature record for the planet in excess of 129°F can be disputed. All of these records, except for the 134°F recorded at Greenland Ranch in Death Valley, California, were made by French colonial era instruments which were found to be irregular as far as the exposure of the screens used to house the temperature instruments. In some cases, the temperature instrument was housed closer to the ground than it should have been. Mr. Burt will have an in-depth analysis of the evidence later this summer when he begins blogging for us.
Figure 3. Visible satellite image of Tropical Cyclone Phet on Wednesday, June 2, 2010.
Tropical Cyclone Phet the 2nd strongest Arabian Sea storm on record
The record heat over southern Asia in May has helped heat up the Arabian Sea to 2°C above normal. The exceptionally warm SSTs have helped fuel a rare major hurricane in the Arabian Sea today, as Tropical Cyclone Phet underwent an impressive bout of rapid intensification this morning to become a Category 4 storm with 145 mph winds. Phet is a Thai word pronounced as Pet, meaning "Diamond". Intense hurricanes are rare in the Arabian Sea, due to the basin's small size, the interference of the summer monsoon, and the frequent presence of dry air and dust from the Arabian Peninsula. Phet is now the second strongest tropical cyclone ever recorded in the Arabian Sea, behind Category 5 Cyclone Gonu of 2007, which devastated Oman. Third place is held by the 2001 India Cyclone 01A and Very Severe Cyclonic Storm ARB 01 (02A), which were Category 3 storms with 125 mph winds.
Phet is over some of the warmest ocean waters on the planet, 30 - 31°C (86 - 88°F), and warm waters in excess of 26.5°C (80°F) extend to a depth of at least 50 meters (165 feet), resulting in a Tropical Cyclone Heat Potential high enough to allow Phet to attain Category 5 status. Phet is under moderate wind shear of 10 - 20 knots. The Joint Typhoon Warning Center (JTWC) is forecasting Phet to become a Category 5 storm later today. The storm is moving slowly north-northwest towards Oman, and could ingest dry air from the Arabian Peninsula on Thursday, resulting in weakening. It now appears likely that Phet will make landfall in Oman before recurving to the northeast and hitting Pakistan. The region of Oman likely to get hit is sparsely populated, so wind and storm surge damage will not be the main concerns. Phet will spread heavy rains over the heavily populated northern regions of Oman, which will likely cause extreme flooding. Phet has the potential to be worse for Oman than Tropical Cyclone Gonu, which did $4.2 billion in damage and killed 50 people in June 2007.
Impact on Pakistan
Phet is on track to make landfall in Pakistan or Iran after hitting Oman. Phet will be much weakened by passage over Oman, and may only be a tropical storm after crossing the Gulf of Oman and arriving at the Iran/Pakistan coast. Still, Phet's rains could easily cause destructive floods in Iran and Pakistan.
The strongest tropical cyclone on record to hit Pakistan was Very Severe Cyclonic Storm ARB 01 (02A), which hit near Karachi on May 20, 1999, as a Category 3 storm with 125 mph winds. According to Wikipedia, 02A killed 700 people did $6 million in damage (1999 USD). I've also found references to a December 15, 1965 cyclone that killed 10,000 near Karachi, Pakistan.
Oil spill update
Moderate onshore winds of 10 - 20 knots out of the southeast to southwest are expected to blow over the northern Gulf of Mexico over most of the next week, resulting increased threats of oil to Alabama, Mississippi, and the Florida Panhandle, according to the latest trajectory forecasts from NOAA. These persistent southwesterly winds will likely bring oil as far east as Fort Walton Beach, Florida, by Monday.
Oil spill resources
My post, What a hurricane would do the Deepwater Horizon oil spill
My post Wednesday with answers to some of the common questions I get about the spill
My post on the Southwest Florida "Forbidden Zone" where surface oil will rarely go
My post on what oil might do to a hurricane
Gulf Oil Blog from the UGA Department of Marine Sciences
Oil Spill Academic Task Force
University of South Florida Ocean Circulation Group oil spill forecasts
ROFFS Deepwater Horizon page
Synthetic Aperture Radar (SAR) imagery from the University of Miami
I'll be back Thursday with more on Phet and an analysis of the new Colorado State University hurricane forecast issued by Phil Klotzbach and Bill Gray issued today.
Jeff Masters
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looking like the 2nd half june should be pretty wet along fl's west coast,it looks like a good tropical influx of moisture for the central and eastern mexico is ahead |
Quoting Katrina2NOLA2010: Trouble with a capital T.... |
Quoting CaneWarning: Yeah good buddy. Wonder what teh odds are he is from south Florida? |
Quoting CycloneOz: Would you rather me have said rotund? |
Quoting DestinJeff: I thought "The Carolinas" would end up in the top 10 somewhere. Maybe Top 20? |
Quoting DestinJeff: LOL....teh chances that it is are? |
Quoting IKE: You noticed that too, sir? |
Quoting CycloneOz: Yeah, it was fun. If you guys want a good chuckle, here's the trip in 2 parts: Chasing Ana Part 1 Chasing Ana Part 2 |
Quoting DestinJeff: Nice list. You forgot one, though. "{storm X} will be a Fish Storm." |
"Joran van der Sloot, former suspect in Natalee Holloway's death, is suspected of killing a woman in Peru, police said.".... per CNN. |
Quoting Levi32: That's just scary. |
Quoting xcool: Don't you just love Bastardi (well at least I do). It was just genius when I read his post several months ago about why Mount Pinatubo helped cause an El Nino to follow the event, and why El Ninos show up at low solar activity. A cooler equatorial belt slows the easterlies (trade winds) which tends to bring on El Nino conditions in the Pacific. Brilliant. |
Quoting palmbaywhoo: Thank God I live in SE Central FL. |
Yesterday, the remnants of Agatha "bursted" and this morning finds the remnants almost gone. While watching the remnants was a good idea and one that certainly should have been of concern, the bursting pattern is something that, unless it is sustained over a 24-hour period, is more a sign of the storm about to die rather than continue. Why? When intense upward motion develops as we saw, it pulls in all the air around it. Unless there is some kind of link between the low and mid levels that can maintain itself when the "burst" relaxes, the compensating sinking in the wake of the burst, and the drier air that is pulled in as well as moist air, will destroy the system. There is a crucial time when the handoff must maintain some form of convection. One can see that happen when such bursts, in their down time, still have smaller convective cumulus towers popping up, usually with some form of banding. This "popcorn" type look on the satellite photo means that the system is already repairing itself in the wake of the large sinking that goes on. As one studies the weather more and more, one can see these kind of situations going on with other features in a much grander sense. For instance, the El Nino last year was in response to the flip in the PDO and the low solar activity... the reduction of sunlight, though subtle, is greatest around the tropics in times of low solar activity; it's why El Ninos love to show up around the low spot in sunspot cycles, they are reactions until the Earth can adjust. In addition, the sudden cooling of the Pacific forced a reactive process, sort of the burst of warmth before the cold set in again.. and the burst of warmth we saw is now being beaten back, globally, a glorified monster Kelvin Flop if you will. The constant back and forth in the atmosphere, be it in bursting patterns which can develop like yesterday with a jet going by to the north and putting the system in a ripe area for upward motion, or the swing in El Nino and La Nina, are all part of planet that unfortunately does not have GARDEN OF EDEN. This is not paradise down here, though some would have you believe it could be. But conflict and resolution, and then conflict again, is a product all through nature as the balance that nature reaches for can only be attained briefly, then the conflict starts anew. This is why the AGW argument, on balance, almost defies intuition, since it is the idea that man is so powerful against nature, that nature will lose to man. Never mind man is part of nature in the first place... it simply reveals the arrogant part. Up and down, back and forth, for every season... as the song, and for those that know where it came from, the verse in scripture it came from. Funny what a leftover tropical system can show you if you want to look |
Quoting TropicalWave: In general, yes, though I made some changes to the forecast numbers since then. I put out another hurricane outlook in the first half of May, which can be viewed here. This one goes into much more detail than the February one, which focused on analog years. |
This is pretty cool :) |
Quoting TropicalWave: Hmmm. |
Quoting Patrap: But if we can reduce or eliminate our use of oil for fuel, we might be able to meet the demand for petroleum based products that can't easily be replaced (plastic IV bags, ziplocs, etc). |
The week 2 NAEFS is very nasty... |
T-storm has passed...sunshine to the north. :) Welcome to summertime in Florida. |
Quoting StSimonsIslandGAGuy: Boy, you must read a lot of books! (He knows I am only joking) Good research. |
№ 494 Perhaps these problems were only noticed when records were set. In my opinion, no raw data should ever been discarded, but should simply be evaluated for what it is. It's obvious that some records--such as older ones, and ones located in poorer countries--are subject to higher uncertainties. |
Quoting HadesGodWyvern: Lol, if you edit a post after posting it, any special characters will be replaced with a symbol representing an unknown character. It can be annoying. |
I'm guessing a S-Thunderstorm Warning will come out of this. Very gusty winds and heavy rain. Guess its not like people would drive any safer. :( |
wow! That was a bad "copy/paste". No wonder I try typing things out more often. |
They got the saw blade off. Now they will try from the other side w/a new blade. |
Pakistan Meteorological Department -------------------------------------- Very Severe Tropical Cyclone %u201CPHET%u201D in Arabian Sea Severe Tropical Cyclone %u201CPHET%u201D in Arabian Sea has intensified into a Very Severe Tropical Cyclone (with maximum sustained wind 64-119 Knots near the centre). It has moved northwestwards along Oman coastal areas during the last 6 hours and now lies at 17.5�N %u2013 60.8�E (about 920 Km southwest of Karachi). It is expected to start recurving towards Sindh coastal areas on Thursday morning. Very Severe Tropical Storm %u201CPHET%u201D is likely to intensify further during the next 24 hours. It may hit land areas South of Karachi on Friday. Storm surge near landfall could be 6 to 8 meters high. Under the influence of this system fairly wide spread rainfall with scattered heavy to very heavy falls accompanied by strong gusty winds are likely in Sindh and Balochistan coastal areas during the next 3 to 4 days. Heavy rains may cause urban/flash flooding in southern Balochistan and Sindh including Karachi. Tropical Cyclone Warning Centre of Pakistan Meteorological Department warned that the fishermen of Sindh and Balochistan who are in the open sea should return to the coast immediately. All fishermen are advised not to venture in open sea till Saturday. Irrigation authorities in Sindh and Balochistan are requested to reduce inflow in irrigation system. |
Quoting Patrap: I wondered how long it would take before the crazy people started with their conspiracy theories. |
Quoting CycloneOz: Oh no, 456 is our budding met genius. I just dabble as best I can lol. I need a met school....Alaska doesn't have one. |
Definitely small hail with this one. |
Time now for an impropmtu "Top 10 Most Common Comments/Words on the Blog, 2010" and... "The Hurricane is headed for my bathroom!!!!" |
Quoting Patrap: I guess. I mean don't get me wrong... we all know the real truth behind the OKC bombing and some of those school shootings years ago, but this is a stretch. |


text: One More Tortoise! Posted on December 13, 2012 by admin Can you ever get enough pictures of tortoises? This is the last one I saw before we left the sanctuary, snack time and not caring about the group taking pictures. Share this:Click to email this to a friendClick to share on LinkedInClick to share on Google+Click to share on RedditClick to share on TumblrClick to share on PinterestClick to share on StumbleUponClick to share on TwitterShare on Facebook


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Contains Naturally Occurring EGCG
Promotes Antioxidant Health*
Green Tea contains beneficial flavonoids, which are natural phytochemicals.* Green Tea Extract provides antioxidant support and health-enhancing properties.*
Nature's Bounty's Guarantee: We use only the finest quality herbs and spices. Each is screened and finely milled for quick release.
Nature's Bounty's preservative-free gelatin capsules contain pure milled herb powder.
Nutrition Questions or Comments? Call NutraPhone® 1-800-433-2990 Mon. - Fri. 9 AM - 7 PM ET or visit us on the web at naturesbounty.com.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
**Nature's Bounty's Natural Whole Herb products utilize ground plant parts to provide the natural components in the amounts found in nature
Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.
Tamper resistant: Do not use if seal under cap is broken or missing. Keep out of reach of children. Store in a dry place and avoid excessive heat.
©Nature's Bounty, Inc.
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This works just as well as more expensive brands.
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Directions: For adults, take two (2) capsules twice daily, preferably with meals. Capsules may be opened and prepared as a tea. As a reminder, discuss the supplements and medications you take with your health care providers.


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Any recommendations on some reasonable priced (under $200?) decent boots? It's been a while since I bought some. I hiked and put a million miles on some old heavy leather boots some years back, then bought some cheapo Columbia goretex that actually haven't been too bad for several years. Since I'm getting up in age, I don't anticipate more than 3-5 mile hikes. My old back is starting to wear. Any suggestions would be appreciated. I think I like the goretex one's tho. I have wimpy ankles, so I do like some support there. Twisted an ankle some years ago with cheap no ankle support boots. Not fun walking out 7 miles! I'd be thrilled if anyone knew of a sale on some good boots around $150 if there is such a thing.
I do have some advice. The following suggests evolved after having worn and reviewed literally hundreds of hiking boots. As a guide book author, magazine writer, gear reviewer and former trail association employee, I've hiked approximately 22,000 miles in the last 24 years -- some years I spent as many as 160 nights out in the backcountry. When selecting new boots: First and foremost, find a pair that FITS. The best made boots in the world will be worst than going barefoot if they don't fit well. Regarding fit, make sure the heel is fairly snug, but the forefoot is a little loose -- your feet will swell throughout the day as you hike. Today's fabric-uppers can be as supportive as all-leather, and they'll typically breathe much better than leather. For dayhikes (and to keep costs down) look for some fabric/leather uppers -- they'll be lighter, cheaper, and still supportive if you get a decent pair. Gore-Tex is great, but most of the other waterproof-breathable liners in boot use these days are equally good (breathability is less vital in the boot application since the upper material tends to retard breathability anyway) I REALLY like the construction and quality of Vasque these days. They tend to have moderately narrow heel cups and slightly wide toe-boxes. Most models of mid-height or higher will provide excellent ankle support IN short, Vasque (the hiking brand of RedWing boots) is KILLING it in boot making these days. They have a great designer. Portland-based Danner makes incredibly tough, durable leather boots that will last you years (I put over 1000 miles into one pair and could have kept going if I had simply resoled them -- which Danner will do for you for a very modest price). They also make the boots in Portland -- one of the few boot makers that still manufacturer in the US (many RedWing boots are still made in Minnesota but not their Vasque branded boots; Keen is mostly US-manufactured). Kayland is another great brand that has a narrower fit. Unfortunately, this is their last season of selling in the US -- still a huge brand in Europe, but they can't get a stronghold going here. Keen boots are very well made and they tend to have a wider fit throughout their line, but you have to be careful about their boots because they somethings use a harder rubber in the outsole that can be slippery on some surfaces (especially wet granite). Some Hi-Tec boots are VERY nice and very affordable. If you want a boot that will last for years Hope that helps. Feel free to PM me if you ahve any questions about specific boots (brands or models -- I have used every brand at one time or another and have used (or had testers use) many current models.
I like Merrells . . . they're light, comfortable, and wear well & I too have a "paper ankle" pursuant to my gym-rat years.
At one point you would see most serious hikers wearing Vasque, and you still can't go wrong with them. I'm wearing Asolo 520s, another classic that's been popular for a couple of decades. This pair has lasted since '96
Yes, thanks! Great info. I have some Merrell "Reflex" that I've been wearing for about 2 years now. I picked them up cheap ($90), as cosmetic blems, and I have been wearing them for all my landscape work and hiking. They are waterproof enough to keep my feet dry in the rain and if my foot slips in the water crossing a creek. I read a review that one should order these 1/2 size larger than one's normal boot size, and I did. They fit me perfectly. They seem about average width, with adequate room in the toe and a snug-but-comfortable fit in the heel. They have sort of a rounded foot bed in the toe area, front-to-back (like bottom rocker on a drift boat), which took some getting used to at first, as my old ones were flatter there. But I have no complaints, now.
Dan, do you have any recommendations for lightweight models? I've been thinking about getting something that would be good for hiking in to a stream or lake and then dry fast after wet wading.
I recommend the Vasque Breeze. I love mine. Fully waterproof for that New Zealand rain. It can handle the Northwest easily.
If you are wet wading in them, avoid Gore-Tex or any other waterproof/breathable membrane. Go for fabric (especially mesh) uppers. Knowing they are going to get wet frequently, I would suggest you look at some trail runners and fast approach-type shoes. They tend to be more breathable and fast drying since runners tend to get more foot-sweat than hikers. Vasque has some great 'runners' that are built on their hiking shoe last, so you get a good, comfortable fit and support. They also have 'sticky' outsoles to reduce slippage on rock and wet surfaces -- that softer rubber will wear faster but provide much better grip. I love this model: http://www.vasque.com/vasque-shoe/7558-vasque/7558-vasque-mens-velocity-2.0-gargoyle-olivebranch For something a little more substantial, check out Oboz brand -- they make some incredible light-hikers at the Bozeman facility. I like this model for its breathability/fast drying. http://www.obozfootwear.com/site/oboz-mens-blaze.html Add some Patagonia river crampons and you will be great shape for hike-in fishing! http://www.patagonia.com/us/product/patagonia-river-crampon?p=79195-0-775
Danner boots always fit my feet. As Dan said-go with a boot that fits. Some of Cabela's boots are made by Danner. I currently have some Danner Pronghorns which I have hunted in for 3 years now. I put anywhere from 5-10 miles per day on them in some pretty rough country with lots of rocks and scree. They have held up great and I think they are about $150. Rick
+1 on Dan's comment about fit. If your new boots don't fit properly, you'll regret it with every step you take. I have fairly wide feet which makes a good fit problematic as not many boots come in widths these days. Several years ago (and after 3 or 4 different trips to various stores) I ended up buying a pair of Vasque Wasatch GTX boots from REI. My diligence in getting the fit just right paid off and after 3 seasons, I literally walked the soles right off them. I loved them so much I had them resoled (by the guy in Fremont who's name I forget), but the new soles delaminated within the first month. Thankfully, REI not only took them back, but gave me the full original purchase price. Their replacements are Zamberlain Civetta Gore-Tex (which are now up to $280 a pair). Although not available in widths, they do fit snug enabling me to buy a half size larger which I shim up with bulky socks. I've got perhaps a hundred miles on them and am quite happy with the way they fit. They're a bit heavier and stiffer than the Wasatch GTXs, making them better for backpacking than day hikes. For short hikes, I found a pair of Keen Alamosa low tops being closed out due to a new color scheme. I paid $59.00 for them at REI about this time last year and they've been bulletproof. Keen shoes in general have wider toe boxes, and the moisture barrier construction in the Alamosas has kept my tootsies dry on even the muddiest rambles. K
Ah. Interesting Ken, and thank you all so far. I just got back from the local Wholesale Sports and tried on the Vasque Wasatch GTX. I was impressed. I just read your post Ken, after coming home and trying them on. They felt pretty comfortable. They had them in Wide sizes which I need. They are selling them there for $175. I believe they had the "Breeze" model also. Nice to know you liked them! I might have to "pop" for a pair. As I said before, I have hiked a million miles also, and after having a well well used pair of old boots, everything has changed for me. I tried on some Danners the other day, but after trying on the Vasque's, they are more comfortable and seemed to have a better fit. I think the Danners are good boots tho.
Dr Larry At 3-5 miles and worries about your ankles, do you have hiking poles? In my experience, there are two schools of thought for foot wear. I still have the dream of hiking the whole PCT (perhaps only a dream). Some who have wrote about doing it suggest sneakers for light weight mobility over traditional boots. I have found that plain sneakers can handle a hell of a lot of conditions, but don't think of traversing snow. On the other end of the spectrum, I've hiked some big trips and in my early naive days was convinced I needed some stiff ass boots to supposedly support me carrying a lot of weight in a backpack. Those boots are still in a box after giving up on them. Damn too stiff for me. Somethings got to give, and for me it was my skin, not the boots. I've got a pair of Vasques that I love. Heck I wear them all the time, even running around on the weekend and they are 10 yrs old. Good quality boots that fit well should last a long time. If you touch snow, you want boots with steel toe box and some kind of heel shank to allow you to kick step into snow. Hybred boots without shank will fail to dig in. If I get the gist of your question, you are looking for recreational walks and pretty well anything that fits well will do you fine. If you are worried about ankles, maybe your investment is in hiking poles more than boots. Poles are great going down hill to give you support to easy and confident stepping. Joe
Joe- Thanks for reminding me about hiking poles. I am now at the age where I need them. My son has gone off to Korea, so I think I will steal his while he's away! They will really help an old man! I wish I could remember the name of my old hiking boots. They were the old heavy leathers. I put many many miles on those babies. I'll have to see if I can dig those out. They should be hung on my wall anyway! There are so many nicer lightweight boots out there since those days. I have no idea how they would compare on a couple solo 50 mile trips I took those on, but did me well. But, I won't go back to those heavy glodhoppers! I am now 64 and I still have some hiking left in my blood. I'm out of shape and want to see if I can get back. I love the high country. I got to love it so much at one point, I started leaving my fly rod at home!!!!!!! Unbelievable I know! Anyway, thanks for reminding me about hiking poles. As long as I find a boot with decent ankle support, no problems will occur. When I twisted my ankle years ago with a pair of cheapo boots, I was on the top of Mt. Jupiter in the Olympics.
DryFlyLarry: I am 57, so I know what you mean by "getting old" and feeling it in the legs, feet, and back. I hunt pheasant and quail every year over on the Palouse near the Snake River. The terrain requires a LOT of hard hiking up and down hills and steep draws, and side-hilling (which is the worst hiking of all on the feet), in all kinds of nasty weather. It is terrific testing ground for boots. My advice is: 1. Try on a lot of boots and find a boot maker whose boot fits your feet. Take some of the socks AND FOOTBED INSERTS you will hike in, and walk around in the store with the boots on, and up and down and sidehill on the incline boot ramp, if the store has one. 2. You might discover that some boots from a bootmaker are good for your feet and other of their models don't fit you well at all. Some Danners fit me perfectly. Other Danner boot models don't fit my feet well at all. Ditto for Cabela's. Last time I was at Cabela's, I tried on 15 different pairs of boots. Found one pair I really liked. Then I waited for them to go on sale, and bought them later. 3. No need to spend $300+, but going too cheap will end up in owning a bad boot. There are good quality boots in the $150 to $250 range. Find the exact boots you want, and then wait for them to go on sale, or look for them on the internet. Every year I am able to buy $200 boots for $120 this way. 4. If the boots are leather, treat them annually with sno-seal or one of the other waterproofing products. They'll last longer, imo. 5. Vasque, Salomon, Danner, and Cabela's make some very good boots. 6. Buy some footbed inserts. I buy several kinds; some have built in arches, some are flat. The best off-the-rack ones (Superfeet, I think, is the brand name) cost about $25. Worth every penny. Sometimes I use one brand of insert for the left foot and a different brand for the right foot. Feet are usually not identical, once they get to be our age. Mix and match till you get a good fit for each foot.
Thank you ImperialStoutRun. And, thank you everyone. I ended up purchasing the Vasque Wasatch GTX! They feel really great! I hope I can say that on the trail again. All of the input was valuable to me. Once I put a few miles on these I'll see if I can remember to report back with how I like them.
Glad to hear you found boots that fit. I hope you'll be as happy with yours as I was with mine. Several thoughts: First, although they have vapor permeable GTX liners, it's still not a bad idea to treat the leather outers with a leather preservative like mink oil to keep them supple and prevent cracking. Second, the earlier point about footbed inserts is a good one. Plantar fasciitis is not fun and is often caused by walking in shoes that don't provide enough footbed support. A pair of good off the shelf orthotics like Superfeet will go a long ways towards keeping your feet happier than the flimsy, flat inserts that come with most boots. Finally, keep an eye on the seam where the molded soles are bonded to the body of the boot. Small hairline separations are the first sign that the sole is getting ready to let go and your warning that it's time for either some corrective action or to start shopping for replacements. By the time took a hard look at my Wasatch GTX's, the front 3-4" on one boot was flapping in the breeze with every step. Unfortunately, boot technology these days means that replacing soles is usually a one and done operation. I miss the old Goodyear welts that could be resoled an almost infinite number of times. Sigh. K
I have several different Danner model boots. Here's probably my favorite for moderate hiking (I am gettting a bit on the older side myself, but use them on daily 3 miles summer hikes at 5,000' elevation @ 4 mph pace on gravel surface, and appreciate their light weight, and overall ankle support: (They also fit your price range) Danner® Radical 452 GTX® Hiker This is the time-tested design that helped to re-establish Danner® as one of the premier hiking boot makers in the world. Based on the advanced Terra Force technology, the Radical 452 GTX is as light as it is tough. While internal and external nylon shanks provide uncompromising stability and responsiveness, a super-soft polyurethane midsole and sturdy footplate provide comfort without sacrificing security. And with the trusted, 100% waterproof protection of GORE- TEX®, your feet will be as dry as they are comfortable. John
Thanks for the tip on the 'new' Danner boots. It was a pleasure to look through their product offerings and see that someone is still making a stitched, replaceable mid- and outer-sole design boot, like http://www.danner.com/boots/mountain-lighttm-ii-mens-womens-hiking-boots.html In reading through the reviews though, it reminded me of one more cautionary about hiking boots which I learned the hard way since my earlier post in this thread. The other day I happened to look closely at the soles on the Keen Targhees I was raving about earlier. To my dismay, I found that the lugs on the outside rear of each heel (thanks to my pronating stride) were so worn that the the midsole is now exposed leaving no heel lugs left and thus much less traction on irregular surfaces. Why the rapid wear I wondered? The easy answer is that I wear them every morning for my 2-3 mile neighborhood walks with the dog. Since my weekday walks are usually on pavement, the harder surface quickly abrades the soft soles that were designed for maximum traction on trails, not sidewalks. The cautionary: if your boots fit so well that you're tempted to wear them in your daily routine (especially if they're waterproof), the softer outer soles intended for hiking and backpacking will wear out quickly when you wear them on pavement. Soles intended for regular pavement use are much harder than those used on hiking boots, and thus last far longer. K
I still have my old Vasque Sundowner, goretex lined boots. While they are a classic and I'd wear them for really rugged hiking, I got a lighter pair of the Keen boots Kent mentions above a couple seasons ago. They are super light and goretex lined also, and no break in required. But there was info in the packaging that the soles are a softer material and smaller lugs, so they won't last so long. They are definitely an investment in comfort over longevity, and should not be used for daily casual dog walking unless you want to buy frequent replacements. Sg


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Camping Village Il Sole Via del Marinaio, 58100 Marina di Grosseto, Italy | ||
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Featuring a restaurant, children's playground, and pool, Camping Village Il Sole offers rustic-style accommodation in Marina di Grosseto. Guests can rent bikes and enjoy nightly entertainment here.
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Set along the SP 158 provincial road, Villaggio Camping Le Marze is 4 km from Marina di Grosseto and 5 km from Castiglione della Pescaia. Surrounded by a cool pine wood, it is opposite its sandy...
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Posts with tag "Brandi Glanville"
Tension Rising Between 'Bonus Mom' LeAnn and Eddie's Ex?
Posted May 9th 2011 at 08:05 AM by Rob Shuter- Filed under:
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- Naughty But Nice With Rob Shuter
LeAnn Rimes insists she and Eddie Cibrian's ex, Brandi Glanville, have made peace, but that didn't stop the country songbird from stirring things up over the weekend by trying to nudge her "bonus mom" self into the spotlight for Mother's Day. "Happy Mother's day weekend to all the Mom's out there," she tweeted on Friday. "The 'Bonus Moms', Godmother's, Grandmothers and anyone who is a woman w...
Report: Eddie Cibrian's Ex Shooting Scenes for 'Real Housewives of Beverly Hills'
Posted May 4th 2011 at 08:00 PM by AOL TV Editors- Filed under:
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Back in February, we reported the story that Eddie Cibrian's ex, Brandi Glanville -- the one he cheated on with his now-second wife LeAnn Rimes -- was possibly in talks to join the cast of Bravo's 'The Real Housewives of Beverly Hills' for its second season. Now, TMZ is saying that the scorned Glanville is a go for the 'Housewives' treatment. "Sources close to the production tell TMZ, Brandi in...
Eddie Cibrian's Ex-Wife Avoids Jail in DUI Case
Posted Apr 1st 2011 at 07:20 PM by Tracey Harrington McCoy- Filed under:
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Brandi Glanville, Eddie Cibrian's ex-wife and mother of his two kids, avoided jail time in her DUI case by pleading no contest in a Beverly Hills court on Friday, RadarOnline.com reported. Glanville pleaded no contest to driving with a blood alcohol level of .08 or higher. The former model was sentenced to 36 months probation and has to pay a $390 fine and complete a three-month alcohol program...
Eddie Cibrian Files For Divorce, Heads to Mexico With LeAnn Rimes
Posted Aug 26th 2009 at 01:10 PM by PopEater Staff- Filed under:
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The marriage of actor Eddie Cibrian and Brandi Glanville is officially over. Glanville has confirmed that Cibrian filed for divorce Monday, after eight years of marriage. "He filed yesterday and I accepted it," Glanvlle told E! News. "We're getting a divorce. We talked to each other yesterday."...
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text: Finland: Finland hits last year's record on Thai berry pickers (Unofficial translation)09/07/2012 - Finland - Finnish Posted by : Country Coordinator Finland According to Finland's Ministry of Foreign affairs over 2800 VISA applications by Thai berrypicker's are accepted, which is 400 more than in last year. Thai berrypickers have come to Finland since 2005, and their numbers have grown evenly. The main reasons for the growing numbers of foreign berrypickers are lack of Finnish berrypickers, urbanization and rising living standards. According to the study accomplished by the University of Lapland Thai berrypickers gained in 60 days approximately 2400 euros, worked 11 hours a day, when their hourly wage level was 3,7 €. According to Finnish life standard hourly wage was low, but for Thais it was good. Conditions of Thai berrypickers are going to be improved based on the Swedish model: berrypickers should have a guaranteed salary against bad harvest. Read more Source : MTV3 |


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Freddy Garcia SP ATL 11 Months
Chris Cotillo of MLBDailyDish.com reports that Freddy Garcia is close to signing with an undisclosed team in Asia.
Garcia opted out of his minor league deal with the Braves after finding out he wasn't going to make the Opening Day roster. He was hoping to find a major league deal somewhere but had only been offered minor league deals to this point. Obviously he's apparently found a better opportunity overseas.
Freddy Garcia SP ATL 11 Months
CBS Sports' Jon Heyman reports that free agent right-hander Freddy Garcia is hoping to land a major league contract.
Garcia was surprisingly cut loose by the Braves toward the end of spring training and has received some minor league offers since, including from the Rangers, but he's holding out for something better. The 37-year-old right-hander had a 4.37 ERA and 46/17 K/BB ratio in 80 1/3 innings over 13 starts and four relief appearances in the majors last year.
Freddy Garcia SP ATL 12 Months
Braves released RHP Freddy Garcia.
Garcia was informed Monday that he would not be on Atlanta's Opening Day roster, so the veteran right-hander packed his things and exercised his opt-out clause. He posted a 4.76 ERA and 14/6 K/BB ratio in 17 innings this spring in the Grapefruit League. The 37-year-old is now back on the open market.
Freddy Garcia SP ATL 12 Months
Freddy Garcia allowed just an unearned run over 5 2/3 innings in beating a Mets split-squad on Sunday.
Garcia allowed two hits, walked one and struck out four in his first strong showing since the early portion of the spring. He'll be a part of the Braves' April rotation, but his status could be revisited once Mike Minor returns.
Freddy Garcia SP ATL 12 Months
Freddy Garcia surrendered four runs -- three earned -- in four innings Thursday in a loss to the Cardinals.
Garcia still seems like a lock for Atlanta's rotation with Mike Minor, Brandon Beachy and Ervin Santana all iffy for the first week or two of the season. However, he might not last much longer than that if Minor and Beachy prove healthy. He has a 6.94 ERA this spring.
Freddy Garcia SP ATL 12 Months
Freddy Garcia flew to Miami on Saturday to be with his wife, who is in labor.
Garcia was perhaps distracted during that day's game, allowing six runs on six hits and four walks over 2 2/3 innings against the Marlins. Once he received the hook, Garcia left the ballpark and began his journey to Miami. He'll be back soon.
Freddy Garcia SP ATL Dec 12 '79
Freddy Garcia was perfect again Monday, setting down all nine Mets he faced in three innings.
Garcia struck out three. He's 15-for-15 retiring batters this spring as he attempts to overtake Alex Wood for a spot in Atlanta's rotation.
Freddy Garcia SP ATL Dec 07 '79
Freddy Garcia retired all six Tigers he faced in his start Wednesday.
Garcia, who was re-signed to a non-guaranteed contract last month, has said he won't accept a minor league assignment from the Braves. He looks like the team's sixth starter right now, but it's possible Alex Wood will be shifted to the pen to open up a spot for him. An injury could factor in, too.
Freddy Garcia SP ATL Nov 24 '79
In Braves camp on a minor league deal, Freddy Garcia said he will not go to Triple-A if he fails to make the Opening Day roster.
"I told my agent, 'If I don't make the team, I'm going home,'" Garcia said. "I'm not going back to the minor leagues, like last year. I did it last year. But if I don't make the team, I'll go home and spend time with the family." With the out clause in Garcia's contract, MLB.com's Mark Bowman says the righty "seems destined to gain a spot on Atlanta's Opening Day roster." He could possibly be the No. 5 starter until Gavin Floyd (elbow) is ready, but more likely he'll be used in long relief.
Freddy Garcia SP ATL Nov 04 '79
Braves re-signed RHP Freddy Garcia to a minor league contract with an invitation to spring training.
Garcia pitched well down the stretch for the Braves last season, even earning a start in their NLDS elimination game loss to the Dodgers. Overall, the right-hander posted a 4.37 ERA over 80 1/3 frames for the Braves and Orioles in 2014. It's possible he could compete for the final spot in the rotation if the Braves wind up keeping Alex Wood in the bullpen. More likely, though, is that he'll represent depth at Triple-A or be used as a long man in the bullpen.


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Think about it. You ever see all these men on a stage at the Same time?! NOPE #Illuminati pic.twitter.com/3VQyzdxRH2
@thechriscarmona @ericstriffler The whole gang actually! @jakebaldino @mw10t pic.twitter.com/jptgmtUNU6
@marktheshark This photo is irrelevant to your tweet but who cares. pic.twitter.com/7dUqnS4i
That one time I said that @ericstriffler looks like @baruchelndg in this pic and people yelled at me. pic.twitter.com/dBDEWwchME
There are still faint glimmers of civilization left in this barbaric slaughterhouse that was once known as humanity.


text:
Ratings based on 241 Verified Reviews
They paid and stayed. We double-checked.
4.0 Room cleanliness
3.8 Service & staff
3.6 Room comfort
3.9 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
by Peterfrom Liverpool
Adequate hotel for a short stay
Posted Jan 19, 2013Pros: The showers and the comfortable bed.
Cons: The dark lifts, bad food, lack of storage space and traffic noise.
Location: % minutes walk fro Tin Hua MTR , very busy street outside. Close to Causeway Bay but not in the main area.
We stayed here because our son had been booked in by his work We spent 6 nights in total which is much longer than the average stay. Our room was small for 2 people but the shower was very good, the bathroom worked and the bed was comfortable. Our TV set did not work on arrival and it was unclear for 2 hours if this was going to be fixed. This is a problem as all information is on the interactive screen. Our son had problems with the TV remote in his room and had similar issues with hotel service.. The main down sides were: 1. The lifts were very dark. It was hard to see where to activate them with your key and where your floor button was . Very slow and a long wait for pick ups. 2. The storage space is very limited -Ok for a single person on an overnight business stay but not 2 people for a week 3. The rooms are not well sound proofed. If you were below the 15th floor (we were on 8) then loud traffic noise accelerating up the incline to the next set of lights keeps you awake from 5-30 am. Lots of noise from the jack hammers of the building site opposite and trucks going to the waste disposal and public tioilet which is the main scenic feature outside the hotel. 4. Breakfast was very poor and not worth paying for. Internet access Ok if you have it pre-booked but expensive otherwise. There is only limited space on the ground floor public area.. Think carefully before you book this hotel for more than one night.
by A verified traveler
"Fallen Empire"
Posted Jan 5, 2013Pros: Strong shower and plenty of hot water.
Cons: The room and the short bed.
Location: Close to MTR, Starbucks & McDonalds
The staff are not at all engaging, really just checked you in and that was that! Housekeeping was tardy & we were required to request room make up and mini bar restock on two occasions after we had been out for the majority of the day. The bed fell short by approximately 12-15 inches which meant I was hanging out of the end of the bed, alright if you are under 5 feet 8 inches. Lift is extremely slow and there are absolutely no facilities like gym or swimming pool. Great proximity to MTR which works like a dream however we would recommend that you stay around Central if your budget extends that far.
for Everyoneby Cholofrom Singapore
small room
Posted Dec 27, 2012Pros: The rooms are quite new
Cons: Bathroom and toilet are small
Location: Quite far from mtr
Room was clean but very small. The toilet was small. Quite difficult to move around it.around the hotel has several restautants. The train station is around 10mins away by walk. Tram station is quite near.
Recommendedby A verified traveler
Not as good as before
Posted Dec 24, 2012 on Hotels.comI have been staying in this hotel for 3 times in the past 4 years. The first 2 stays were very nice. Even though the size of he room is typical HK style(very small), it has everything you need. The location is very convenient, and the neighborhood is quiet and convenient. However, the recent stay has some downgrade. After 4 years, the hotel appears to be obviously wear off.(The furniture and equipment inside the room does not appear nice anymore.) The room is only average clean now. Also, the elevator is very slow.
Recommendedby A verified traveler
Posted Dec 15, 2012 on Hotels.com
for Everyoneby A verified traveler
Good location
Posted Dec 7, 2012Pros: It's location
Cons: The room size
Location: It's a 3 minutes walk from the Ting Hau MTR station. It's also a 5 minutes walk from the A11 bus stop from the airport, a very convenient location
The room is really small but I had stayed at other hotels in Causeway Bay, the rooms were just as small. The price was right and it's very convenient for transportation and food. I was under the impression that the room has wi-fi, but it didn't. I had to pay an additional $15 US per 24 hours for internect connection. I was not too happy with this.
Recommendedby A verified traveler
Posted Dec 1, 2012 on Hotels.com
for Getaway With Friendsby A verified traveler
Posted Dec 1, 2012 on Hotels.com
for Business Travelersby A verified traveler
Posted Nov 29, 2012 on Hotels.com
Recommendedby A verified traveler
Posted Nov 29, 2012 on Hotels.com


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Anya Hindmarch mini gracie - if you have one when you you use it ?
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I say it is. What about you?
Greatest System Ever?
SNES is definitely the Greatest System Ever.
The games, and just the significance of the franchises that debuted and were refined on the system are just amazing.
PS2 is close second in my opinion.
Unquestionably my favorite system ever. I'm sure it's half nostalgia talking, but it really doesn't matter... I doubt I'll ever have as much fun gaming as I did back in the early to mid 90's with my SNES.
"The 1st system I ever had, the best system i ever had :DSame.
I regret having sold most of my SNES games on Ebay, though. I want them back.
For sure, Snes has the two best Final Fantasy ever, which are IV and VI (sorry, Cloud and Sephiroth fanboys), with no doubt the BEST action rpgs ever (Terranigma, Secret of Mana, Zelda: LttP...), the best and most frantic Contra, the two ULTIMATE 2D platform games (Donkey Kong Country series and Yoshi's Island), Mario Kart, Super Mario All-stars is the biggest killer app in history aside from Tetris for GB...and it goes on like this.
So, veredict: Best. System. Ever. The only system that could be near Snes would be Game Boy or the original NES
It would be great if developers stopped creating so many fancy graphics and they tried to achieve such gameplay and fun that Snes games have.The only hope nowadays for old school gamers like us is the NDS I think, there are lots of remakes out there from Snes classics and even japan-only releases
But I thought the Genesis did what Nintendon't?
For me it's a tie between SNES and the N64.
The memories of playing Mario Kart and Donkey Kong Country for days on end with my cousins definitely makes the SNES a contender. Though the hundreds of hours of Mario Kart 64 and Super Smash Brothers along with games like Rogue Squadron and Banjo Kazooie really make the 64 stick out more. That song from Spiral Mountain in Banjo Kazooie will forever be stuck in my head.
I would say that the SNES tops my list of greatest systems of all time.
The best system is probably the PS1. It had games for everyone.
However, my favorite is still dreamcast.
I personally think Genesis is the best. I like Sega's exclusives more than Nintendo's. Sonic The Hedgehog 2>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>All Super Mario game (or any platformer for that matter)
Yeah, I loved the snes, but I was young and traded it, I'll buy one off ebay sometime again.
"I would say that the SNES tops my list of greatest systems of all time.
1. SNES2. PS13. Genesis4. Dreamcast5. Atari 2600"
That's a pretty good list.PureRok said:
"Is it sad that I like 2D games more often than 3D, especially when it comes to RPGs?"No, it's not sad at all. Well, let me rephrase that. There seems to be more great 2D games (well at least IMO) because it's much harder to make a good 3D game. So many series have failed to be good in 3D (Earthworm Jim, Final Fight, etc.)
the snes just has every thing i wanted , and i still buy games for mine , my long list of games is over at gamespot under mariokart64fan overthere, but i will not be using that site no more, why let them ban me ill quit before that happens lol and i just did
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Skills required:
1. In-depth research
2. Good writing skills
3. Ability to analyze search results
4. Basic Business development (email, followups, etc)
5. Ability to communicate well verbally in English
6. Primary and secondary research
Please do not apply if you can not prove these skills.
To apply, send examples of your work in these areas.
Project needs to start immediately! Thanks!
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