text:
Modeselektor, 'Monkeytown' (Monkeytown)
These simian-obsessed Berliners' approach to electronica has always been monkey see, monkey do very, very well. Infamous omnivores, they somehow fold Ibiza trance, noisy early-'80s electronic body music, and twitchy glitch-hop into each album. But Monkeytown imbues all this with a newly sourced warmth. Lacing 8-bit burble, buoyant bass, fizzy synths, and non-quantized rhythms, songs like "Blue Clouds" and "Shipwreck" (featuring Thom Yorke's disembodied coo) clearly seem to reference Los Angeles' beat scene. But Modeselektor sprinkle the Flying Lotusstyle funk sparingly, melting their Teutonic cool just enough to reveal a previously missing musical link: soulfulness.
Dance Music Industry Fights For Its Right
Rave festivals are doing massive business and causing massive headaches for the cities that host them. But undaunted promoters and artists have a plan to keep the dance revolution from being derailed again. The image seemed piped into the streets of Los Angeles from San Francisco's Summer of Love. There he is, in the middle of Hollywood Boulevard, a lone tousled and shirtless soldier for peace, tan shoulders and sinewy arm supporting a raised fist with two fingers sticking up like bunny ears. His back is to the camera, and the aperture is focused on the 30-odd LAPD riot-squad members staring him down. They're helmeted and armed. He's wearing neon bracelets. The photo was taken in late July outside a movie premiere, an invite-only screening for Electric Daisy Carnival Experience, a documentary celebrating the titular dance festival.
Smashing Pumpkins Lean on Classics in L.A.
Quasar, /?kwâ?zär/, noun: 1. "A massive and extremely remote celestial object, emitting exceptionally large amounts of energy, and typically having a star-like image" (Google). 2. The name of the new song the Smashing Pumpkins opened with at their sold-out tour kickoff at Los Angeles' Wiltern Theatre. 3. Useful shorthand for describing Chicago alterna-rock legend Billy Corgan with (or without) his band. Freeze frame on a moment about an hour into the group's 20-odd-song set. They've just crushed a true-to-form resurrection of "Frail and Bedazzled" from 1994's b-sides collection Pisces Iscariot, closing with a fierce guitar duel that careened from thrashing jags into blistering harmonics out to transcendent squeal.
We Survived Odd Future's Insane U.S. Tour Kickoff
San Diego's House of Blues was packed by 8 p.m., sold out and stuffed full of rowdy fans anticipating the arrival of Odd Future, there to kick off their first headlining North American tour. The stage was empty and the house music low, but that didn't stop anybody who wanted to from crowd-surfing, throwing shit and shouting like they were experiencing the apex of a Sex Pistols gig. Several chants were attempted -- Wolf Gang! Golf Wang! Free Earl! Fuck Chris Brown! Swag! -- often at the same time from different sections of the crowd.
Jens Lekman, 'An Argument With Myself' (Secretly Canadian)
"Shut up! / No, you shut up!" sings fey Swedish popster Jens Lekman to/at himself on his new EP's title track. It's the first release since 2007's intensely precious masterstroke Night Falls Over Kortedala, and he seems conflicted. Said schizo musings are set to tropical guitar and percussion fit for Gloria Estefan's "Conga," while closer "So This Guy at My Office" sounds like Jonathan Richman covering Bob Marley -- feats of strange merit, but awkward fits for his detailed lyrical screeds. The real triumph is "Waiting for Kirsten," a bucolic strummer that turns a tale of stalking Ms. Dunst through Gothenburg into a treatise on free health care.
Das Racist Get Wild at Hometown Tour Kickoff
Toward the end of Das Racist's sold-out hometown gig at New York City's Bowery Ballroom, on the eve of the release of the group's first commercial LP, Relax, something truly strange happened. Kool A.D. reclined into the crowd, rapped a verse from his back while doing a lap in his fans' hands, and was propped back up onstage as three male dancers scantily clad in fur and feathers arrived and executed some sort of tribal ballet to the jittery Bollywood beat of the new single, "Michael Jackson." It was goofy and impressive and more than a little awkward -- the latter part owing both to the suddenness of the act, and the fact that the men were black, dressed in aboriginal garb and dancing between Das Racist and a screen streaming footage of Blaxploitation archetype Sweet Sweetback's Baadasssss Song.
Kreayshawn and V-Nasty Crush Hollywood
When the curtains opened on The Roxy's stage for Kreayshawn's sold-out Hollywood gig Saturday night, the already ecstatic audience was greeted with footage of the Oakland rapper's increasingly familiar face. Over a doom-dipped, chopped, and screwed version of her other web hit "Bumpin Bumpin" (a measly 3.4 million views compared to the 13.5 amassed by "Gucci Gucci"), her image chatted into the camera, mean-mugged, and grinned, and wore a handful of different expressions, jewels and hair styles all obviously aiming (pandering perhaps) for the iconic. No doubt for most of the crowd, this was the only way the YouTube star had previously existed: in 2-D, sometimes grainy, sometimes in focus, always oddly photogenic in a junk culture, ironic thrifting, general loudness kind of way.
Nero, 'Welcome Reality' (MTA)
"I don't know where we're going," coos Alana Watson on this English dubstep duo's single "Guilt"; but that's just a setup for the air-sucking dropout and explosion of ugly, bass-driven bluster that follows. Watson gives Nero's robotic skronk a rare injection of humanity, and the U.K. producers are smart enough to build most of their debut full-length around her husky voice, skipping the sampled spasticity of Skrillex in favor of Daft Punk's melodic big beat ("Doomsday"), '80s-inspired electro-pop ("Crush"), and stadium-sized mash-ups of squealing guitar and windy synths ("Me & You").
Breaking Out: Givers
When Hurricane Katrina hit in 2005, Givers singer Tiffany Lamson had just started her freshman year at the University of New Orleans. She'd moved away from Lafayette, Louisiana, where she'd sung in the church band (her father was the pastor), only to see her new apartment and all her belongings drowned in 15 feet of water. Fittingly, considering Givers' penchant for joyous pop, Lamson saw the experience as a positive. "It was awesome to be smacked in the face with that," she says. "It changes your perspective." It also helped start the band. Lamson's friend Taylor Guarisco, another Lafayette native, had been playing bass in zydeco ensembles. With school on hold and nowhere to live, the two returned home with little to do. So they started making music.
Red Hot Chili Peppers Rock Big Sur
On Wednesday night, Red Hot Chili Peppers debuted new songs to an intimate audience under the stars in Big Sur, California. Their appearance at the Henry Miller Library was announced only three hours before the band took the stage, and it was free for the 300 lucky fans and friends who made it through the worn wooden gate. Rounded out by guitarist Josh Klinghoffer, who replaced John Frusciante, as well as a percussionist and keyboardist, RHCP performed five songs from their long-awaited, Rick Rubin-produced tenth album I'm With You (due out August 30), interspersed with a handful of crowd-pleasing classics. "We got new songs, we got old songs in the deadhead redwoods out here," said Anthony Kiedis cooly, wearing a tuxedo jacket and an OFF! trucker cap. A towering pine behind him was lit by a pink strobe. The air smelled green and felt damp.


text:
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Marques Colston re-structuring contract to stay with Saints?
An encouraging couple of tweets regarding Colston's chances of staying below:
Schefter says the Saints are expected to restructure Colston's deal on NFL Insiders
— Nick Underhill (@nick_underhill) March 3, 2015
Schefter said releasing Colston is unlikely.
— Nick Underhill (@nick_underhill) March 3, 2015
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subset: commoncrawl


text:
Revisions to these Guidelines
About the journal
Editorial Policies
- Transparent Process
- Authorship Guidelines
- Use of Living Organisms
- Animal welfare
- Human subjects
- Biosecurity
- Availability of Published Material and Data
- Conflicts of Interest
- Scientific Integrity
- Corrigenda, errata and refutations
- Data Collection and Presentation
- Originality & Plagiarism
- Embargo Policy
- Citation
Editorial Process
Manuscript Preparation
- Research Articles
- Text Format
- References
- Tables
- Conventions and Abbreviations
- Figure Format
- Figure/Data Presentation
- Expanded View (replaces Supplementary Information)
- Unpublished Data
- Data Deposition
- Other Article Types
For Acceptance and Publication
- Speed of Publication
- Proofs
- Press Embargo
- Charges
- Open Access & Self Archiving
- Author Licence Agreement
- Digital Object Identifier
Help and Contact
About the Journal
Aims and Scope
EMBO Molecular Medicine is a peer-reviewed, online open access journal dedicated to a new research discipline at the interface between clinical research and basic biology. It offers clinicians and researchers in this area the opportunity to publish their best work in a broadly distributed and highly visible forum, thereby lending a strong impetus to this important and rapidly developing field and helping to forge new links between clinicians and molecular biologists. Studies based on model organisms also fall within the scope of the journal, provided that the results presented are evidently and directly relevant to human disease.
The journal is one of four journals owned and run by EMBO and is editorially entirely independent of its publisher Wiley-Blackwell. For further details on our relationship to other EMBO publications, please see below.
EMBO Molecular Medicine publishes research papers as full-length Research Articles and short Reports. In addition, the journal publishes Editorials and Review articles in innovative formats that target a broad and non-specialized audience as well as Closeups and Correspondences.
Areas covered include, but are not limited to:
- Aging
- Cancer biology
- Differentiation and development
- Endocrinology and metabolic diseases
- Genomics, transcriptomics, proteomics, metabolomics of disease
- Gene therapy
- Human genetics, epigenetics and genomics
- Immunology and inflammation
- Infectious diseases
- Molecular diagnostics and imaging
- Molecular pharmacology and drug discovery
- Neurodegeneration, neurological diseases and myopathies
- Pain and sensory defects
- Stem cells and regenerative medicine
- Systems medicine
- Vascular and cardiovascular biology
Article Types
EMBO Molecular Medicine publishes the following article types:
Research Articles and Reports
Original research papers, reporting novel molecular research highly relevant to the understanding, prevention, treatment or cure of human diseases. Reports are concise manuscripts that highlight a specific finding, model or methodology with a high impact on the field of molecular medicine.
A broad and scholarly overview of a particular topic related to molecular medicine, noting the most recent developments in the field. They are supplemented with explanations for non-specialist readers and online links to relevant sources of additional information.Bridge the Gap
These articles will help both basic and clinical researchers to better understand each other's perspectives and define common goals. Authors are encouraged to suggest new strategies and avenues of investigation that may fill the gaps they perceive as existing between the discovery of a biological mechanism and the application of the resultant concepts to the better understanding of a specific disease, its diagnosis, prevention or treatment. Alternatively, from a clinical perspective, authors might highlight disease phenotypes they consider to be poorly understood in molecular terms and suggest lines of research that would lead to such understanding.
Closeup articles
These articles are short commentaries commissioned on specific articles, discussing the advance and broader implications of the respective study or studies.
Editorials and Perspectives
These are opinion pieces that focus on important issues regarding biomedical research, its community and human health in general. Editorials are written by our editors, whereas Perspectives are invited by the journal editors.
A Correspondence is a flexible format that may include anything of interest to the journal's readers, from policy debates to announcements to 'matters arising' from research papers published in EMBO Molecular Medicine (see below for further information).
Editorial Policies
Submission of a manuscript implies that it reports unpublished work and that neither itself, nor parts of it, have been published or are under consideration for publication elsewhere. By submitting a manuscript, the authors guarantee that they have the appropriate authority from their employers and/or funding agencies to publish the work. Any related work under consideration, review, revision or accepted for publication elsewhere must accompany the submission if they are relevant to its scientific assessment.
The journal reserves the right not to publish material that has already been formally published, completely or substantially, including in established digital media such as blogs. All EMBO Press journals encourage prior publication on recognized non-peer-reviewed, community preprint servers such as arXiv for commenting by other scientists before formal submission to the journal. The details of the preprint server concerned and any accession numbers or DOIs must be included in the cover letter accompanying submission of the manuscript.
Transparent Process
All EMBO Press journals have made the editorial process transparent for all accepted manuscripts by publishing as an online supplementary document all correspondence between authors and the editorial office relevant to the decision process. This will by default include all referee comments directed to the authors, as well as the authors' point-by-point responses. Internal communications and informal consultations between editors and editorial advisors will remain excluded from these policies. Likewise, referee anonymity will be strictly maintained, unless a referee chooses to sign his or her report. Authors who are, for specific reasons or as a matter of principle, not comfortable with these disclosures will have the possibility to opt out of the transparent process at any stage prior to publication. More information about the EMBO Press Transparent Process can be found below and on the EMBO Press website.
Authorship Guidelines
Submission of a paper implies that all authors have seen and approved the manuscript and its contents, and that they are aware of the responsibilities connected to authorship. Signatures from all the authors are not required; it is the corresponding author's responsibility to obtain agreement from all authors supporting the submission. All authors will be notified upon peer-review of a new manuscript and upon acceptance of a manuscript, but the editorial office corresponds only with the Corresponding Author, whose responsibility it is to communicate with all other authors.
The nature of every author's contribution must be specified both in the manuscript submission system and in the manuscript under the heading "Author Contributions".
Our authorship policies conform to international standards (see, for example, ICMJE authorship guidelines).
The journal encourages the submission of a completed author checklist (right click to download) at submission (which covers animal welfare, human subjects, data deposition and ethics), and will require it to be filled and returned to the editorial office at revision, either via the online submission system (upload as a supplementary file) or by email to the editorial office. All information covered in the checklist should be included in the manuscript.
Use of living organisms
For Research Articles submitted to EMBO Press journals reporting experiments on live vertebrates and/or higher invertebrates, the corresponding author must confirm that all experiments were performed in accordance with relevant guidelines and regulations. The manuscript must include a statement in the Materials and Methods identifying the institutional and/or licensing committee approving the experiments, including any relevant details. For experiments involving human subjects, authors must identify the committee approving the experiments, and include with their submission a statement confirming that informed consent was obtained from all subjects.
Right click to download and complete the author checklist here.
Animal welfare
For studies reporting experiments on live vertebrates and/or higher invertebrates, the corresponding author must confirm that all experiments were performed in accordance with relevant guidelines and regulations. The manuscript must include a statement in the Materials and Methods identifying the institutional and/or licensing committee approving the experiments. The editors reserve the right to consult with board members or external experts and reject manuscripts that contain animal experiments that do not conform to NIH or MRC guidelines for animal welfare. For further information see: Office of Laboratory Animal Welfare; MRC Guidance and Policy Documents.
The journal encourages authors to follow the ARRIVE guidelines (PLoS Biol. 8(6), e1000412, 2010) for reporting studies involving animals. Please see the following website for details: http://www.equator-network.org/reporting-guidelines/improving-bioscience-research-reporting-the-arrive-guidelines-for-reporting-animal-research/
Right click to download and complete the author checklist here.
Human Subjects
For experiments involving human subjects the corresponding author must identify the committee approving the experiments and include a statement that informed consent was obtained from all subjects and that the experiments conformed to the principles set out in the WMA Declaration of Helsinki and the Department of Health and Human Services Belmont Report. Editors or referees may request further documentation confirming that this is the case.
Any restrictions on the availability or on the use of human data or samples should be clearly specified in the manuscript. Any restrictions that may detract from the overall impact of a study or undermine its reproducibility will be taken into account in the editorial decision.
For clinical trials reporting, the authors should fill out a CONSORT flow diagram and submit it as supplementary information. The journal also encourages authors to follow the CONSORT reporting guidelines http://www.consort-statement.org. Please see the EQUATOR website for details. Clinical trials should also be registered as recommended by the International Committee of Medical Journal Editors, and the trial registration number should be provided.
Right click to download and complete the author checklist here.
Reporting Guidelines
Authors are encouraged to follow the EQUATOR Network reporting guidelines for the following:
Type of Study | Guidelines |
Animal research | ARRIVE |
Parallel group randomized trials | CONSORT |
Conensus-based Clinical Case Reporting | CARE |
Prognostic marker studies | REMARK |
Diagnostic Accuracy | STARD |
Meta-analysis of observational studies | MOOSE |
Systematic reviews and meta-analysis | PRISMA |
Observational studies | STROBE |
Genetic association studies | STREGA |
Statistical analyses and methods | STAMPL |
Microarray/deep sequencing studies | MIAME |
Studies using biospecimens | BRISQ |
Planned research and results from experiments should be evaluated at an early stage for possible dual use concerns. In such cases, authors should first consult with an appropriate local body concerning the implications for biosecurity and public health. For further information see the U.S. National Science Advisory Board for Biosecurity's recommendations and the US National Select Agent Registry.
Authors should explicitly describe any potential biosecurity implications and the local body's assessment in their cover letter at submission and in the author checklist. The threat posed by the potential abuse of certain experimental data or material for bioweapons, terrorist or other criminal activities may require that editors balance the risks and benefits of publication. The ultimate decision whether to publish the paper as submitted or with suggested changes is the prerogative of the editors after consultation with board members or external experts in biosafety, biosecurity, or public and environmental health.
Right click to download and complete the author checklist here.
Availability of published material and data
It is understood that by publishing a paper in this journal, the authors agree to make available to colleagues in academic research all new reagents, including organisms (or means to produce them), viruses, cells, nucleic acids and antibodies, that were used in the research reported and that are not available from public repositories or commercial suppliers. Human patient samples and data should be made available in accordance with the relevant ethical standards. Materials must be made available at a reasonable cost that reflects production and distribution. The distribution of published materials does not automatically confer a right of co-authorship. Right click to download and complete the author checklist here.
The journal will only review and publish manuscripts if the authors agree to make all data that cannot be published in the journal itself (e.g. novel nucleotide sequences, structural data, or data from large-scale gene expression experiments) freely available, where possible in an appropriate public database (detailed guidelines can be found below).
Right click to download and complete the author checklist here.
Conflicts of interest
In the interests of transparency and to help editors and reviewers assess any potential bias, the journal requires authors of original research papers to declare any competing commercial interests in relation to the submitted work. It is difficult to specify a threshold at which a financial interest becomes significant, but as a practical guideline, we would suggest this to be any undeclared interest that could embarrass you were it to become publicly known. Referees and editors are also subject to Conflict of Interest regulations.
Scientific Integrity
The editorial staff are strongly committed to maintaining high standards of integrity of the published scientific record. The journal requests that authors take note of and adhere to guidelines established by the U.S. Department of Health and Human Services Office of Research Integrity (http://ori.dhhs.gov). The journal will investigate suspected instances of scientific fraud, inappropriate image manipulation or processing, plagiarism, duplicate publication and other cases that violate research ethics. Depending on the outcome of these investigations, the journal may opt to publish errata or corrigenda (see below), or, in cases of serious scientific misconduct, either to ask authors to retract their paper, or to impose retraction on them. In such cases, the authors' employers may also be contacted. The journal may also issue an editorial note attached to the paper to alert readers to an ongoing investigation. As a matter of policy, the journal will collaborate with independent institutional investigations into misconduct and usually accept the outcome of such investigations.
All EMBO Press journals are members of the Committee on Publication Ethics (COPE).
Corrigenda, errata and refutations
An erratum is notification of an important error made by the journal
A corrigendum is notification of an important error made by the author(s).
An editorial note may be used to alert readers to a specific issue related to a paper.
Refutations of articles published in the journal can be considered for the Correspondence section of the journal. Such correspondence will almost always include data to support the arguments of the correspondent. The original authors of that article will be offered the opportunity to respond side-by-side with the correspondence. Both pieces will be peer reviewed at the discretion of the editor and acceptance depends on the strength of the arguments raised as well as the importance of the matter to a general readership. Publication of the correspondence does not automatically entail publication of a response of the authors of the challenged research paper. After one round of correspondence, the journal will consider the matter closed and will not publish further exchanges.
Data collection and presentation
Presented data must represent the findings in an unbiased, accurate and transparent manner. This includes appropriate statistical analysis and image processing. For further details, please refer to these guidelines.
The Editors reserve the right to request minimally processed versions of figures and the source data that were used to assemble the figure from the authors of a paper under consideration, or of a paper already published in the journal.
Originality and Plagiarism
The editors require that any information published in the journal represents a substantially novel contribution to the scientific record. Any manuscript submitted to the journal should therefore not contain content that has been formally published in a peer reviewed journal or another formally citable manner, whether in print or electronic. This includes websites, blogs and the news media. Recognized, non-peer-reviewed pre-print servers and conference presentations (including summaries) are not considered prior publication (see below).
Embargo Policy
The content of papers and any associated press releases is strictly embargoed until the official date of publication of a manuscript. Accepted contributions can be discussed with the media from one week before the publication date provided the journalist respects the embargo date. We will press release selected papers with summaries. Authors may arrange their own publicity, but must adhere to the embargo conditions. Further details can be provided by the editorial office.
Comprehensive and accurate citation of the relevant literature is essential. We require citation of the primary literature wherever appropriate. There are no limits on the total number of references in the bibliography, and the reference list is not subject to manuscript length format requirements (for details, see below). Similarly, page charges will apply only to the body of a published article, not to the reference list.
Editorial Process
All submissions are initially assessed by a dedicated scientific editor specialised in the scientific topics covered in the manuscript, and may also be evaluated by an appropriate Editorial Advisory Board member, Senior Editor, or other external expert advisor. Only manuscripts judged by the editors to be potentially suitable for publication in the journal are sent out for formal peer review, so that manuscripts with a low probability of success can be returned to the authors without delay. Manuscripts are generally reviewed by three appropriate experts selected by the editors. Based on their arguments and recommendations, the decision concerning publication, revision or rejection is taken, sometimes after further consultation with the referees, the Editorial Advisory Board or the authors. Revisions are invited only for manuscripts that have a high probability of acceptance after one major round of revision. Authors may appeal decisions if there is concrete evidence for a misunderstanding or mistake at the editorial or referee level. Appeals are evaluated in depth and without prejudice.
The journal makes the editorial process transparent for all accepted manuscripts, by publishing as an online supplementary document (the Review Process File, RPF) all correspondence between authors and the editorial office relevant to the decision process. This will include all referee comments directed to the authors, as well as the authors' point-by-point responses. Internal communications and informal consultations between editors, editorial advisors or referees will remain excluded from these documents. Importantly, referee anonymity will be strictly maintained. Authors have the possibility to opt out of the transparent process at any stage prior to publication.
To further facilitate transparency, the journal has removed the "Confidential Comments" field from our referee reporting forms. This is to ensure that the authors receive all information pertinent to the decision made on a manuscript. Referees should be aware that all comments will be transmitted to the authors and the other referees. Should there be any issues with the manuscript, in particular concerns about ethical standards, data integrity, biosecurity, or conflicts of an academic or commercial nature that need to be communicated directly and confidentially to the editor, this can be done by email.
Please see the EMBO Press website for more information on these policies.
Transfer policies
The EMBO Press journals are editorially independent from their publishers and one another.
Authors can choose to transfer manuscripts rejected from any one of the EMBO Press journals to any other of the EMBO Press journals by following the instructions appended to the editorial decision letter. Manuscripts transferred post-review will automatically include the referees' reports and identities, and the editors will aim to use these reports in arriving at a rapid decision. Editors may choose to seek additional advice from referees or editorial advisory board members in cases where this would enhance informed decision-making.
Manuscript Preparation
EMBO Molecular Medicine publishes the following article types:
- Research Articles - have a length limit of ~60,000 characters (excluding references)
- Reports - have a length limit of ~22,000 characters (excluding references) and 3 figures
- Reviews
- Bridge the Gap
- Closeup
- Perspective
- Correspondence
Research Article Submission
The following guidelines refer to Research Articles. While published manuscripts are expected to conform tightly to the following guidelines, this is not a requirement at first submission.
Manuscripts must be written in clear and concise English and be intelligible to a broad readership. Prior to submission, authors may benefit from having their manuscript reviewed for clarity by colleagues and/or by using one of the many English language-editing services that are available.
Text Format
The Editorial Office will only accept text files in RTF or MS Word format. The final character count must be clearly indicated on the title page of the manuscript. Revised manuscripts that do not comply with the formatting guidelines, or exceed the length restrictions, may be returned to the authors for amendment.
Please submit the full text (including figure legends, expanded view figure legends, tables, and references) as a single MS Word or RTF file.
Submitted manuscripts should be divided into the following sections:
- Title page
- Abstract
- Introduction
- Results
- Discussion
- Materials and Methods
- Acknowledgements
- Author Contributions
- Conflict of Interest
- References
- Figure Legends
- Table Legends
- Expanded View Figure Legends
Title Page
The title should be short and informative, and should not contain any abbreviations (for example, Epithelial-Mesenchymal Transition should not be abbreviated to EMT). However, commonly used gene or protein acronyms are acceptable. The total length of the title should not exceed 100 characters (including spaces). Serial titles are not accepted.
The full name of each author should be given. Multiple first-authorships are acceptable and should be indicated. Numbers in superscript should be used to indicate the department, institution, city with postal code and country, for each author. Any changes of address may also be given in numbered footnotes. It is possible to name more than one author as the correspondent of a published article, although we will by default address all correspondence to the single author listed as Corresponding Author upon submission.
Please provide a running title of no more than 50 characters including spaces.
Up to five keywords, which may or may not appear in the title, should be given in alphabetical order, below the abstract, each separated by a slash (/).
This should be a single paragraph not exceeding 175 words. The Abstract should be comprehensible to readers before they have read the paper, and abbreviations should be avoided where possible (as for the title). Reference citations within the abstract are not permitted. The abstract should describe all key novel findings of the study.
The Introduction should be succinct and without subheadings. It should provide only the necessary background information, rather than comprise a comprehensive review of the field. Citation of the primary literature is required where appropriate (see section on Citation Policy).
The Results section, and associated figures, tables and Expanded View information, must accurately describe the findings of the study. Figure order should follow the text. Detailed methodological descriptions should be restricted to the Materials and Methods section. 'Data not shown' is not permitted (see below): all significant data should be displayed in the main figures or Expanded View information.
The Discussion should accurately interpret the results, but not be repetitive with the Results section. Authors are encouraged to discuss their work in the broader context. Related published data must be appropriately discussed and cited. Speculation is allowed but should be clearly labelled as such. For shorter articles, the Results and Discussion sections can be combined.
Materials and methods
This section should contain sufficient detail so that all experimental procedures can be repeated by others, in conjunction with cited references. Reagents must be described in such a way as to allow readers to identify them unequivocally and/or reproduce them. For example, antibodies epitopes should be described and siRNA and other probe sequences must be provided. In cases where detailed methods cannot be described within the length limits of the article, additional Materials and Methods can be included as part of the Expanded View Appendix. This additional information should, however, not be of immediate importance for the understanding of the manuscript, and it is not permissible to move the entire "Materials and methods" section into the Appendix.
These should be placed at the end of the text and not in footnotes. Personal acknowledgements should precede those of institutions or agencies. Grant numbers are permissible. Dedications are discouraged.
Author Contribution
The journal requires a statement specifying the contributions of every author. Further details on authorship can be found here.
Conflict of Interest
The journal requires a statement specifying whether or not the authors have a Conflict of Interest (see above for details). In the case of a Conflict of Interest, this must be specified.
As a matter of policy, the journal requires the citation of primary literature (over review articles) wherever appropriate. Authors are responsible for the accuracy of the references. Authors are responsible for ensuring that the related literature is accurately and comprehensively discussed and cited. Review articles should only be cited for general background information, the proposal of certain concepts or similar purposes, whereas primary research articles should preferentially be referenced to introduce the question being addressed or to support the conclusions and interpretations of the results. Articles in press can be cited with the explicit permission corresponding author of the study; the journal name has to be included and, where available, the Digital Object Identifier.
Only articles that have been published or that are accepted for publication at a named publication should be cited in the reference list. In the text of the manuscript, a reference should be cited by author and year of publication; no more than two authors may be cited per reference; 'et al' should be used if there are more than two authors (i.e. Smith & Jones, 2003; Smith et al, 2000). Papers accepted for publication must be cited with the corresponding author's permission and should include title and all author names (or initials if any of the authors are co-authors of the present contribution), as well as either the DOI, if available, or the term 'in press'. In the reference list, citations should be listed in alphabetical order and then chronologically, with the authors' surnames and initials inverted; where there are more than 20 authors on a paper, the first 20 will be listed, followed by 'et al.'. Publications by the same author(s) in the same year should be identified with a, b, c after the year of publication. The name of each journal should be abbreviated according to Index Medicus and italicized. References should therefore be listed (and will subsequently appear in print) as follows:
Akhmedkhanov A, Toniolo P, Zeleniuch-Jacquotte A, Koenig KL, Shore RE (2002) Aspirin and lung cancer in women. Br J Cancer 87: 49-53
Book chapters and books can be cited in the following way:
Price SR, Oubridge C, Varani G, Nagai K (1998) Preparation of RNA-protein complexes for X-ray crystallography and NMR. In RNA-Protein Interaction: Practical Approach, Smith C (ed) pp 37-74. Oxford: Oxford University Press
Sambrook J, Fritsch E & Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbour Press, Cold Spring Harbour, New York, USA
Links to online resources and websites should be cited in the text only, and should be available long-term (e.g. permalinks or DOI wherever possible). URLs should not appear in the reference list.
Tables should be typed on separate sheets and numbered consecutively with Roman numerals (I, II, III, IV,). Tables should be self-explanatory and include a brief descriptive title. Footnotes to tables indicated by lower-case superscript letters are acceptable, but they should not include extensive experimental detail.
Conventions and Abbreviations
In general, the journal follows conventions given in Scientific Style and Format: The CBE Manual for Authors, Editors and Publishers (1994) Cambridge University Press, Cambridge, UK, 6th edn. Please follow Chemical Abstracts and its indexes for chemical names. For guidance in the use of biochemical terminology follow the recommendations issued by the IUPAC-IUBMB Joint Commission on Biochemical Nomenclature. In general, genes and genotypes should be indicated in italics; proteins and phenotypes should not be italicized.
Authors should use approved gene and gene product nomenclature and apply the italicization and capitalization formatting as appropriate for each organism's standard nomenclature. Please consult the appropriate nomenclature databases for correct gene names and symbols. Some useful general resources are: Entrez Gene (http://www.ncbi.nlm.nih.gov/gene); UniProt (http://www.uniprot.org/).
Try to restrict the use of abbreviations to SI symbols (standard units of measurements) and those recommended by the International Union of Pure and Applied Chemistry (IUPAC). Abbreviations should be defined in brackets after their first mention in the text, not in a list of abbreviations. SI symbols and symbols of chemical elements may be used without definition in the body of the paper. Abbreviations of standard biochemical compounds, e.g. ATP, DNA, nucleotides in nucleic acids, and amino acids in proteins, need not be defined. Common language abbreviations, such as e.g. or i.e., should not be used.
Figure Legends
Figure legends should contain sufficient information to allow the reader to follow the data presented without referring back to the text, but should not be redundant with the Results section. Each figure must contain a heading, and each panel a subheading. All symbols and abbreviations used in the figure must be defined, unless they are common abbreviations or have already been defined in the text. Experimental details should, where possible, be given in the Materials and Methods section, and not repeated in the figure legends. Figure legends should be formatted such that each panel, or group of panels, has its own entry with the panel letter (or range) on the left and the description on the right. The description of specific panels can be preceded or followed by free text describing features, statistics or values pertinent to all panels.
Figure 1 - Generation of hiPSCs from a patient with type-2 long-QT syndrome.
A Genetic screening in the patient revealed the heterozygous single-nucleotide mutation Aright arrowT in exon 13 of the KCNH2 gene, in position 2987 of the coding sequence (CDS) (c.A2987T, NM_000238.3), resulting in the substitution of an asparagine with an isoleucine at position 996 of the protein (N996I, NP_000229.1).
B The N996I mutation (red dot) is located in the C-terminal of the HERG protein, which is made of six trans-membrane domains (S1-S6), an amino (NH2) domain, a carboxyl (COOH) domain, and a pore (P) region.
C Example of a hiPSC colony harbouring the c.A2987T (N996I) KCNH2 mutation (LQT2-hiPSCsN996I). Scale bar: 400 mu;m.
D Immunofluorescence analysis of pluripotency markers SSEA4 (green) and NANOG (red) in a representative LQT2-hiPSCN996I clone, with nuclear staining (DNA, blue). The image on the right is a magnification of the area framed in the left image. Scale bars: 100 mu;m (left image); 50 mu;m (right image).
Figure Formatting
Figures and Expanded View figures should be presented in the order they are mentioned in the text. Figures use the numbering system Fig 1, while Expanded View figures use the system Fig EV1. The figure count in each is separate, such that there will be both a Fig 1 and a Fig EV1 (and so on) in a manuscript.
The final size of figures will be between 82 mm and 172 mm wide on the printed page. Please bear this in mind when submitting your manuscript for review and allow for sufficient resolution at a suitable size.
Figures divided into parts should be labelled with an upper-case, bold letter (Helvetica Font). Figures with several parts should also be in proportion, with consistently sized lettering so that the whole figure can be reduced by the same amount to the smallest size at which the essential details are visible. Use Courier font for sequence data and Symbol font for any symbols.
All lettering should be done using standard fonts (Helvetica, Times, Symbol, Courier) and retained in a separate layer (if possible) so that the production team can adapt any labels to the journal's style if necessary. All fonts used for labelling the figures should also be embedded in the final files if the software package offers this option.
Scale bars, rather than magnification factors, should be used, with the length of the bar defined in the legend rather than on the bar itself. In general, visual cues on the figure itself are preferred rather than verbal explanations (for example, 'broken line' or 'filled black triangles') in the legend.
When preparing figures of microscopy images, please note that we strongly encourage the use of colours that are suitable for colour-blind readers: for example, the use of magenta/green is preferred over red/green for 2-channel images.
For publication, we require PowerPoint, TIFF or EPS files in PC or Macintosh format, preferably from PhotoShop or Illustrator software. We cannot accept Freehand, Canvas, CorelDRAW or MacDrawPro files. These files must be converted to postscript (eps) format. For any figures submitted in photoshop or tiff format we require layered files to be sent whereby all text, arrows or additional attributes are placed on individual layers within the file. For line art/charts/graphs we prefer to work with Adobe Illustrator AI or EPS files. We can also accept high-resolution PDF files.
All colour artwork must be submitted in CMYK colour mode. When converting files from RGB, please consider that the final figures will be printed on coated paper, using Euroscale process inks. If you are not familiar with these specifications, or are not sure how to apply them within your software package, please consult a local graphics expert. Ultimately, it is important that all colours look satisfactory after conversion to CMYK, both on screen and when printed on different printers.
Non-vector graphics should be preserved at high resolution: 300 dpi minimum at final size for greyscale or colour halftone images, and 600 dpi minimum for bitmap (b/w) artwork. Combinations of monochrome and greyscale/photographs should be at 600 dpi.
Further detailed guidelines regarding the preparation of artwork is available to download in this document [pdf].
The journal does not have colour charges for figures, and the authors are therefore welcome to submit full colour figures.
Figure/Data Presentation
Figures must accurately reflect the results of the experiments. Appropriate controls, markers and scale bars should be included in all panels. Statistical tests must be clearly defined and appropriate to the data.
Image Processing
Images submitted with a manuscript for review should be minimally processed (for instance, to add arrows to a micrograph). Authors should retain their unprocessed data and metadata files, as editors may request them to aid in manuscript evaluation. If unprocessed data are unavailable, manuscript evaluation may be stalled until the issue is resolved.
A certain degree of image processing is acceptable for publication (and for some experiments, fields and techniques is unavoidable), but the final image must correctly represent the original data and conform to community standards. The guidelines below will aid in accurate data presentation at the image processing level; authors must also take care to exercise prudence during data acquisition, where misrepresentation must equally be avoided. Where appropriate, manuscripts should include further Methods as part of the Expanded View that describe for each figure the pertinent instrument settings, acquisition conditions and processing changes.
Authors should list all image acquisition tools and image processing software packages used. Authors should document key image-gathering settings and processing manipulations in the Methods.
Images gathered at different times or from different locations should not be combined into a single image, unless it is stated that the resultant image is a product of time-averaged data or a time-lapse sequence. If juxtaposing images is essential, the borders should be clearly demarcated in the figure and described in the legend.
The use of touch-up tools, such as cloning and healing tools in Photoshop, or any feature that deliberately obscures manipulations, is to be avoided.
Processing (such as changing brightness and contrast) is appropriate only when it is applied equally across the entire image and is applied equally to controls. Contrast should not be adjusted so that data disappear. Excessive manipulations, such as processing to emphasize one region in the image at the expense of others (for example, through the use of a biased choice of threshold settings), is inappropriate, as is emphasizing experimental data relative to the control.
When submitting revised final figures upon conditional acceptance, authors may be asked to submit original, minimally processed images.
Electrophoretic gels and blots
Positive and negative controls, as well as molecular size markers, should be included on each gel and blot. For previously characterized antibodies, a citation must be provided. For antibodies less well characterized in the system under study, a detailed characterization that demonstrates not only the specificity of the antibody, but also the range of reactivity of the reagent in the assay, should be published as part of the Expanded View. The display of cropped gels and blots in the main paper is permitted if it improves the clarity and conciseness of the presentation. Cropped gels in the paper must retain all important bands, and space (several band-widths) should be retained above and below the relevant band(s). Vertically sliced images that juxtapose lanes that were non-adjacent in the gel must have a clear separation or a black line delineating the boundary between the gels. Quantitative comparisons between samples on different gels/blots are discouraged; if this is unavoidable, the figure legend must state that the samples derive from the same experiment and that gels/blots were processed in parallel. Loading controls must be run on the same blot. High-contrast gels and blots are discouraged, as overexposure may mask additional bands. Authors should strive for exposures with gray backgrounds. Multiple exposures should be presented in the Expanded View information if high contrast is unavoidable. Immunoblots should be surrounded by a black line to indicate the borders of the blot, if the background is faint. For quantitative comparisons, appropriate reagents, controls and imaging methods with linear signal ranges should be used.
Authors should be prepared to supply the editors with original data on request, at the resolution collected, from which their images were generated. Cells from multiple fields should not be juxtaposed in a single field; instead multiple supporting fields of cells should be shown as part of the Expanded View. Specific guidelines: Adjustments should be applied to the entire image. Threshold manipulation, expansion or contraction of signal ranges and the altering of high signals should be avoided. If 'Pseudo-colouring' and nonlinear adjustment (for example 'gamma changes') are used, this must be disclosed. Adjustments of individual colour channels are sometimes necessary on 'merged' images, but this should be noted in the figure legend. We encourage inclusion of the following with the final revised version of the manuscript for publication: In the Methods, specify the type of equipment (microscopes/objective lenses, cameras, detectors, filter model and batch number) and acquisition software used. Although we appreciate that there is some variation between instruments, equipment settings for critical measurements should also be listed. A further Methods section as part of the Expanded View (or part of a larger Methods section) titled 'equipment and settings' should list for each image: acquisition information, including time and space resolution data (xyzt and pixel dimensions); image bit depth; experimental conditions such as temperature and imaging medium; and fluorochromes (excitation and emission wavelengths or ranges, filters, dichroic beamsplitters, if any). The display lookup table (LUT) and the quantitative map between the LUT and the bitmap should be provided, especially when rainbow pseudocolor is used. If the LUT is linear and covers the full range of the data, that should be stated. Processing software should be named and manipulations indicated (such as type of deconvolution, three-dimensional reconstructions, surface and volume rendering, 'gamma changes', filtering, thresholding and projection). Authors should state the measured resolution at which an image was acquired and any downstream processing or averaging that enhances the resolution of the image.
Statistical analysis
All statistical analyses performed in the work must be clearly described, including the name of the test performed and the number (n) of independent experiments underlying each analysis. Authors must justify the use of a particular test and explain whether their data conform to the assumptions of the tests. In particular:
- When using statistical methods based on the normal distribution authors should explain how they tested their data for normality. If the data do not meet the assumptions of the test, then a non-parametric alternative should be used.
- When making multiple statistical comparisons on a single data set, authors should explain how they adjusted the alpha level to avoid an inflated Type I error rate, or they should select statistical tests appropriate for multiple groups.
- For each experiment, the number of both technical and biological replicates should be clearly stated. Biological replicates are derived from independent experiments using separately obtained biological samples, while technical replicates are created by repeated measurements on the same biological sample. In general, technical replicates should be averaged before any statistical inference tests are performed.
- In cases where n is small, appropriate statistical tests should be employed and justified in the text.
Since for complex biological experiments the number of independent repeats of a measurement often has to be limited for practical reasons, statistical measures with a very small n are commonplace. However, statistical measures applied to too small a sample size are not significant and they can suggest a false level of significance. We recommend that the actual individual data from each experiment should be plotted if n < 5, alongside an error bar. In cases where n is small, a justification for the use of the statistical test employed has to be provided. Presenting a single 'typical result' of n experiments is sometimes unavoidable, but should be accompanied by an indication of the variability of data between independent experiments. If n is not based on independent experiments (that is, n merely represents replicates of a measurement), statistics may still be useful, but a detailed description of the repeated measurement is required. Figure legends should contain a basic description of n, P, and any relevant statistical tests or error bars.
For more information on the appropriate use of standard deviation, standard error, and confidence intervals please refer to Cumming et al (2007).
Graphs must include clearly labelled error bars for cases where more than two independent experiments have been performed (error bars should not be shown for technical replicates).
Authors must justify the use of a particular test and explain whether their data conform to the assumptions of the tests.
Expanded View (replacing Supplementary Information)
[Note: authors do NOT need to reformat their manuscript at first submission. The guidelines below are to be followed when submitting a revision.]
All data and information that are essential to support the scientific arguments made in the paper should be presented in figures that will be included in the main paper. Figures, tables or text sections that are not required by the general reader to understand the principle findings of the paper and that would disrupt the flow of paper should be submitted as 'Expanded View', which will be displayed in collapsible form and will replace Supplementary Information.
The printed article must be complete and self-explanatory without the Expanded View content. Please refer to each Expanded View item in the body of the text or the figure legends. You should also include the text "Expanded View information is available at The EMBO Journal Online' at the end of the article and before the references.
Expanded View Figures, tables or text represent an integral part of the published paper and benefit from the same peer-review and editorial production process as the other sections of the paper. Please note the Expanded View items are restricted to information essential to support the scientific arguments made in the paper. Peripheral, tangential or further reaching data and information should not be presented. Reference to 'data not shown' is discouraged'.
Expanded View items (Figures, Tables, Text) are displayed inline in the HTML version of the paper and are individually expandable/collapsible [note: currently files are linked to for download but full HTML rendering will come in the near future].
The article should be self-explanatory without the Expanded View sections. The scope of Expanded View sections should therefore be limited to the following categories:
- controls and results from technical optimization experiments
- replication or confirmation of previous results
- negative results
- extended methods and detailed protocols
- mathematical demonstrations, algorithms, computer code and models
- datasets
Note that controls and replicates to directly support the data presented in a figure should be supplied as 'Source Data' file linked to the relevant figure.
All Expanded View items should be cited in the text as "Figure E1", "Figure E2", Table E1", "Table E2", etc..., throughout the text.
Every Expanded View item should be accompanied by a legend that explains the content of the item. Expanded View legends should simply be included in the main manuscript file after the legends to the Figures and use the conventional format:
- "Figure E1. Title of the item. Explanatory legend."
Each Expanded View item should in principle be supplied as an individual file. If this is not possible due to the nature of the information provided in Expanded View and the way it needs to be presented, a single PDF file (including a Table of Contents) can also be provided in exceptional cases and in agreement with the editors.
The following formats are accepted:
- Expanded View Figure: jpg, gif, tiff, eps, pdf
- Expanded View Tables (less than 50 rows): Word, Excel
- Expanded View Text: Word, LaTeX
- Expanded View Datasets and large tables (more than 50 rows): Excel, tab-delimited text, comma-separated values (csv), XML
- Expanded View Code and Models: plain text, XML, ZIP compressed archives (including a README text file at the top level to detail the content and nature of each file included in the archive)
- Expanded View Movie: mpeg, mov, avi
For the PDF version of the article, all displayable Expanded View items (Figures, Text and small tables) are automatically converted into PDF format and appended to the end of the article as part of a single downloadable 'PDF+' file. Files marked 'PDF' display the paper without Expandable View Items.
Unpublished Data
The journal does not permit citation of "Data not shown". All data referred to in the paper should be displayed in the main or Expanded View figures. "Unpublished observations" may be referred to in exceptional cases, where these are data peripheral to the major message of the paper and are intended to form part of a future or separate study. Personal communications (Author name(s), personal communications) must be authorised in writing by those involved, and the authorisation sent to the editorial office at time of submission. Care should be taken that embargo policies are not contravened. References to manuscripts in preparation or submitted, but not yet accepted, should be cited in the text as (Author names(s), in preparation), and should not be included in the list of references. Copies of such manuscripts should be enclosed at submission for reviewing purposes where relevant, as should manuscripts in press, which should be cited in the reference list (see above)
Data deposition
Large-scale datasets, sequences, atomic coordinates and computational models should be deposited in one of the relevant public databases prior to submission (provided private access is available at the database) and authors should include accession codes in the Materials & Methods section. The suggested wording for referring to accession identifiers in a manuscript is the following: "The [protein interaction | microarray | mass spectrometry ] data from this publication have been submitted to the [name of the database] database [URL] and assigned the identifier [accession | permalink | hashtag ]." If necessary, please include in the manuscript the relevant information (username and password) for confidential access by peer-reviewers.
Data for which no suitable public database exists should be included, if possible, as dataset files in the Expanded View. In cases where data can not be confidentially deposited in a public database, and is too large to be included in the Expanded View, please contact the editorial office for advice on how to make these data available for refereeing purposes.
Functional genomics data
Microarray and sequencing-based functional genomics data should be deposited in the ArrayExpress (http://www.ebi.ac.uk/arrayexpress/), GEO (http://www.ncbi.nlm.nih.gov/geo/) or CIBEX (http://cibex.nig.ac.jp/index.jsp) databases in compliance to the MIAME (http://www.mged.org/Workgroups/MIAME/miame.html) standards and the MINSEQE (http://www.mged.org/minseqe/) draft proposal.
Proteomics, metabolomics and molecular interactions
Mass spectrometry datasets should be deposited in a machine-readable format (e.g. mzML if possible) in one of the major public database, for example Pride (http://www.ebi.ac.uk/pride/) or PeptideAtlas (http://www.peptideatlas.org) and authors should follow the MIAPE recommendations (http://www.psidev.info/index.php?q=node/91).
Molecular interaction data should be deposited with a member of the International Molecular Exchange Consortium (IMEx, http://www.imexconsortium.org) prior to submission of the manuscript. Authors should follow the MIMIx recommendations (http://www.psidev.info/index.php?q=node/278).
Metabolomics data should be deposited following the recommendations of the Metabolomics Standards Initiative (MSI) (http://metabolomicssociety.org/index.php/resources/metabolomics-standards) in a recognised repository such as MetaboLights (http://www.ebi.ac.uk/metabolights/).
Sequence data
Nucleotide sequence data should be submitted to an International Nucleotide Sequence Database Collaboration member: GenBank (http://www.ncbi.nlm.nih.gov/genbank/), EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl/) or DDBJ (http://www.ddbj.nig.ac.jp/).
Structural data
The journal accepts and follows the recommendations of the International Union of Crystallography (IUCr), with regard to the deposition and release of macromolecular structural data. These guidelines are set out in the article by the IUCr Commission on Biological Macromolecules in Acta Crystallographica (2000), D56, 2. In summary, they state that all publications must be accompanied by deposition of both the atomic coordinates and the structure-factor amplitudes in the appropriate database (PDB or NDB). In the case of low-resolution structures for which only a chain trace is reported, a set of C alpha positions and structure-factor amplitudes may be sufficient.
For NMR structures, data deposited should include resonance assignments, and all restraints used in structure determination (NOEs, spin-spin coupling constants, amide exchange rates, etc) and the derived atomic coordinates for both an individual structure and for a family of acceptable structures.
Structures of biological macromolecules solved by electron microscopy must be submitted to the EMDB database at http://emdatabank.org. For a brief description of the database, see Lawson et al. (2011) Nucleic Acids Res. 39: D456-D464.
Human clinical and genomic datasets
The journal encourages authors to provide access to genotype and clinical data with as few restrictions as possible while respecting ethical obligations to the patients and relevant medical and legal issues. If practically possible and compatible with the individual consent agreement used in the study, such data should be deposited in one of the major public access-controlled repositories such as dbGAP (http://www.ncbi.nlm.nih.gov/gap) or EGA (http://www.ebi.ac.uk/ega). Simple genetic polymorphisms should be submitted to dbSNP (http://www.ncbi.nlm.nih.gov/SNP/).
Right click to download and complete the author checklist here.
Other Article Types
Reports are short publications focusing on a particularly provocative and novel aspect of a study. They should have an Abstract phrased in terms that are comprehensible to readers outside the discipline. Results and Discussion sections can be combined. The remaining sections are organized as described above for Articles.The total character count (including spaces) for Reports, excluding the methods, references, tables and Expanded View material, but including title page, abstract and figure legends should not exceed 22,000 characters (the exact character count to be stated on the title page). Reports have, in principle, a maximum of 3 Figures.
In all other regards, reports should follow the same instructions as Research Articles.
Reviews provide the reader with the background to, and a broad overview of a particular topic related to molecular medicine, while noting the most recent developments in the field. They are supplemented with explanations for non-specialist readers, online links to relevant sources of additional information as well as a Pending Issues section. Reviews must be based on published data. The total character count for a Review, including spaces, figure legends and references, may not exceed 50,000 characters and the exact character count should be stated on the front page of the manuscript. We strongly encourage authors to include explanatory Figures and Tables. Our in-house graphics editor will aid in the preparation of the final figures for publication if a review is accepted. Reviews are usually commissioned but can also be submitted. All manuscripts submitted for this section will be peer-reviewed and may be extensively edited. Referencing guidelines are the same as for Research Articles.Bridge the Gap
Bridge the Gap articles will help both basic and clinical researchers to better understand each other's perspectives and define common goals. Authors are encouraged to suggest new strategies and avenues of investigation that may fill the gaps they perceive as existing between the discovery of a biological mechanism and the application of the resultant concepts to the better understanding of a specific disease, its diagnosis, prevention or treatment. Alternatively, from a clinical perspective, authors may highlight disease phenotypes that they consider to be poorly understood in molecular terms and suggest lines of research that would lead to such understanding. Bridge the Gap articles are supplemented with explanations for non-specialist readers and online links to relevant sources of additional information. The total character count, including spaces, figure legends and references, may not exceed 30,000 characters and the exact character count should be stated on the front page of the manuscript. We strongly encourage including explanatory figures, models and tables.
Bridge the Gap articles are usually commissioned but can also be submitted. All manuscripts submitted for this section will be peer-reviewed and may be extensively edited.
Referencing guidelines are the same as for research articles.
Closeup articles are short, focused highlights of a specific development [often an original article(s) published in our journal or elsewhere] in our understanding of a clinically relevant issue. They are aimed at non-specialist readers and are supplemented with explanatory text and online links to relevant sources of additional information. The total character count for a Closeup, including spaces, figure legends and references, may not exceed 10,000 characters and the exact character count should be stated on the front page of the manuscript. The number of references should not exceed 10. We strongly encourage authors to include an explanatory figure. Closeups are usually commissioned by the Editors. We are also open to original un-invited submissions but would urge you to contact the Editorial Office beforehand. All manuscripts submitted for this section will be peer-reviewed and may be extensively edited.Referencing guidelines are the same as for research articles.
Editorials and Perspectives are opinion pieces that focus on issues of high importance to biomedical research, the corresponding research communities and human health in general. These are short pieces of approximately 1000 words. Editorials are written by our editors, while Perspectives are invited by the journal editors. They are non peer-reviewed opinion pieces that focus on a particular scientific or sociopolitical topic pertinent to the Molecular Medicine community. They are intended to reflect primarily the views of the author(s) on the issue under review and authors are encouraged to put forward their own ideas and opinions.Referencing guidelines are the same as for research articles.
A Correspondence is a flexible format that may include anything of interest to the journal's readers, from policy debates to announcements to 'matters arising' from research papers. A Correspondence may describe primary research data, but only one Figure and one Table are allowed. A Correspondence has no abstract and should be limited to 1000 words in principle. The number of references should not exceed 10 for either the Correspondence or its Reply. Expanded View material can in principle only be in the form of structured data or dataset files. Authors must submit a competing financial interests statement, which is included only if they declare that they have competing interests. In cases where a Correspondence is critical of a previous research paper, the authors are normally given the option of publishing a brief reply. Criticism of opinions or other secondary matter does not involve an automatic right of reply. Refutations and commentaries on previously published articles are always peer reviewed. Other types of Correspondence may be peer reviewed at the editors' discretion. Referencing guidelines are the same as for research articles.
Presubmission Enquiries
Presubmission enquires allow authors to receive rapid feedback on whether a manuscript in preparation is likely to be of interest to the journal. Presubmission enquiries should be submitted via our online submission system (http://embomolmed.msubmit.net) or by e-mail and should minimally include a list of all authors, a cover letter and an abstract.
If you have already prepared a manuscript, you should submit this via our online system as an article, rather than sending a presubmission enquiry. This allows the editors to make a more informed decision as to whether or not the manuscript is potentially appropriate for the journal. Initial editorial assessment of full submissions is usually rapid, with an average decision time of four days. Full manuscripts should not have been submitted elsewhere, even if they are sent as a presubmission enquiry.
How to Submit
We use an online manuscript submission and tracking system: http://embomolmed.msubmit.net
In order to submit, you must have registered for an account (on any of the four EMBO Press journals). After this, please consult the following instrutions for submission via our secure server. Please be sure that your browser is set to accept cookies. Our tracking system requires cookies for proper operation.
Please refrain from submitting your manuscript by e-mail attachment.
For original submissions, you will need to upload a cover letter, a Word file of the text of the manuscript (including figure legends), and a PDF file containing all the figures. Alternatively, individual figure files can be uploaded separately, but please note that this can be more time-consuming than a PDF submission. You can also submit all of these files within a single ZIP file. The system will expand it for you. Additional Expanded View files can also be uploaded when applicable (please refer to the section 'Expanded View' above).
Once you have submitted your files and the conversion is in progress, it can take up to 30 minutes before the PDF, created in the conversion process, is ready for approval. Please contact the editorial office if the conversion engine takes longer than this. It is important to check the quality of the figures in the converted PDF before approving the submission. You can also upload your own PDF for each file if this is faster and/or provides the quality you require. Please remember that your manuscript will not be submitted until you have approved the converted or uploaded PDF files.
To avoid any unnecessary delays, please refer to the most current electronic formatting guidelines when preparing your manuscript for submission. Authors using computer systems with non-Western type encoding are strongly encouraged to eliminate all occurrences of non-standard fonts in both the manuscript and the figures. We suggest using only the fonts Times, Symbol, Courier and Helvetica.
We will acknowledge receipt of a submitted manuscript by e-mail to the Corresponding author as soon as the quality check (appropriate manuscript format and image quality) has been completed. All further correspondence will also be by e-mail. Please ensure that your servers are set up to allow e-mails from the journal, and contact us if you do not receive an acknowledgement e-mail within a few days of submission.
Manuscript Status
You can check the status of your manuscript at any time in the review process by:
- Accessing the system with your password or link sent to you in the acknowledgement e-mail.
- Clicking on the link represented by your manuscript tracking number and abbreviated title.
- Clicking on the "Check Status" link at the bottom of the displayed page.
This procedure will display tracking information about where your manuscript is in the submission/peer review process.
Please feel free to contact the editorial office with status queries.
Submission of Revisions
When a manuscript is returned to authors for revision, the revised version should be submitted within three months of the authors' receipt of the referee reports, unless another date is specified in the decision letter. Please contact the editor by the deadline in cases where extra time is required for revision. Additional time may be granted upon request at the Editors' discretion, assuming the conceptual advance of the study stands (with regard to the current literature). As a matter of policy, we do not consider any competing manuscripts published during the specified revision period as negatively impacting on the conceptual advance presented by your study. However, we request that you contact the editor as soon as possible upon publication of any related work, to discuss how to proceed. Only a single round of revision is generally permitted. The initial decision letter on the original version of the manuscript provides a URL that should be used for submission of revised manuscripts. Please do not upload revisions as new submissions.
Revisions should be accompanied by a point-by-point response to the referees' comments and editorial decision letter, in PDF or Word format. To facilitate the re-evaluation, we encourage authors to intercalate their response with the referee comments.
Revisions must also be accompanied by a completed author checklist. Right click to download and complete the author checklist here.
At this stage, you must also conform for our formatting guidelines.
For Acceptance and Publication
Before acceptance and transfer to our publishers, manuscripts will be checked for appropriate formatting and image processing, and for plagiarism. We cannot proceed to acceptance until data are available in public databases when required; see above for details.
Speed of publication
The journal aims for rapid publication of papers, usually within 15 to 20 working days. Please help the Editors and publisher avoid delays by providing current e-mail address(es), telephone and fax numbers at which author(s) can be contacted.
The journal offers a fast-track (10 working day) publication route for manuscripts under competition. Please notify the editor as soon as possible in such circumstances.
Authors will be sent an e-mail with a link to access and annotate their proof. It is the authors' responsibility to check that the final proof is accurate. In the interests of speed, corrections should be submitted within 24 hours. If you have any trouble submitting corrections through the system, please contact the production office immediately. Essential changes of an extensive nature may be made only by insertion of a 'Note added in proof', and only with the approval of the Editors. A charge will be made to authors who insist on extensive amendment within the text at the page proof stage. Excessive alterations may delay publication of the article.
Press Embargo
When discussing unpublished data (including data in accepted papers not yet published) with the press, authors should take care not to break the journal embargo policy (see above for details)
Open Access and Charges
The journal levies an Article Processing Charge (APC) of 2,950 EUROS (3,900 USD/GBP 2,500) for each Research Articles or Reports accepted for publication. There are no additional costs (such as page charges or submission charges).
No charges apply for Reviews, Closeups, Bridge the Gaps, Perspectives or Correspondence.
At revision stage, authors are prompted by the system to fill in their funding and payment details.
We will automatically waive or discount charges for corresponding authors working in countries covered by the Research4Life Initiative (see the Wiley Open Access Waiver Country List). In exceptional circumstances charges may be reduced for authors who can provide evidence that they are unable to pay the fees.
Upon acceptance, the corresponding author will receive instructions by email for completing the relevant license forms.
Processing of an accepted manuscript for publication can only proceed once the funding and payment details have been provided via the system and the licence to publish has been returned.
Authors who receive funding from an agency or institution with a Wiley Open Access Account do not pay directly - the charge is paid by the institution or funder. Authors whose institutions have paid the Wiley Open Access partner fee are eligible for a discount on the publication charge - on acceptance a discounted fee is payable by the author. Please see additional details on the online payment page when you submit your revised manuscript.
Molecular Systems Biology articles are freely accessible to all via the Internet and are also deposited immediately upon publication, without embargo, to the Open Access repository PubMed Central.
Copyright on any article published by Molecular Systems Biology is retained by the author(s).
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Help and Contact
If you need additional help during submission, you can click on the help signs (icon) spread throughout the system. A help dialogue will pop up with context sensitive help. Should further assistance be required, then please contact MTS help. For questions regarding our policies and guidelines, please contact the EMBO Molecular Medicine editorial office (email@example.com).


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Tag: goals
GDC 2010: The secret to App Store success
For the last panel of GDC 2010 day two, David Whatley of Critical Thought took the stage to talk about the App Store success he found with his games geoDefense and geoDefense Swarm, and almost dared other iPhone developers to follow his "guaranteed plan" to go from "zero to Time Magazine." He's got...
TUAW at E3: The Sims 3 for iPhone
The Sims 3 pretty faithfully recreates the Sims experience on Apple's handhelds, albeit in a more streamlined version. While the handheld port avoids a lot of the new complexity of the latest PC release, the core Sims experience is still here -- you can create a Sim, give it a personality and a ho...
Surfin' Safari publishes WebKit Project Goals
Surfin' Safari is the official blog of the team that works on WebKit, the open source rendering engine that powers Safari and just about any other app on Mac OS X that allows you to view web pages, such as NetNewsWire, iSale, RapidWeaver and many, many more. Heck, these days WebKit is going far beyo...
Software Updates
more updates- Apple Remote Desktop updated with Yosemite support
- OS X Yosemite 10.10.2, iOS 8.1.3 updates now available
- Sports Illustrated 120 SPORTS channel comes to Apple TV
- Logic Pro X update brings AirDrop support, new effects, tools, and more
- Parallels Access 2.5 released, adds file manager, computer-to-computer remote access
- The Google Translate iOS app is about to get a lot smarter


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Destroying the AGR is actually the hard part (assume you're talking about the FHJ), I died over and over trying to get it sometimes. It's very awkward to hit.
FHJ is probably the most stressful to finish up.. those 10 player controlled score streaks? Last time i checked, not everyone is MLG at getting Vtols and chodestars..


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Found a cheap and simple way to label my taps on my kegerator. Check it out. Let me know what you think. Check out this video on YouTube:
Ægir was a god who would host a party where all the gods would drink the beer he brewed for them. He made this in a giant kettle that Thor had brought. The cups in Ægir's hall were always full, magically refilling themselves when emptied.
Great idea, very creative!
That is a pretty cool idea. You could cut a slit in the top of the plastic supplied handles and it could slide into that and be a party of the handle.
Am I missing something . . . I see no video... Bryan
??? Me too.
"Carpe Diem"
That's weird. I clicked on it and it worked for me. No clue
Seems to be working now - neat idea. Bryan


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Top Definition
a sexy latina awesome bitch that belongs only to a nother being known as Jon
Don't stare at that Vianny, she belongs to Jon
by jojojohnson7410
December 06, 2009
Type your email address below to get our free Urban Word of the Day every morning!
Emails are sent from email@example.com. We'll never spam you.


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Phoenix Film Critics Society Awards 2004
5th PFCS Awards
December 21, 2004
Best Film:
The Aviator
The 5th Phoenix Film Critics Society Awards, honouring the best in film for 2004, were given by the Phoenix Film Critics Society on December 21, 2004.[1]
Best Actor
Best Actress
Best Animated Film
Best Cinematography
Best Costume Design
Best Director
Best Documentary Film
Best Editing
Best Ensemble Acting
Best Film
Best Foreign Language Film
Best Live Action Family Film
Best Makeup
Best Original Score
Best Original Song
Best Production Design
Best Screenplay - Adapted
Best Screenplay - Original
Best Supporting Actor
Best Supporting Actress
Best Use of Previously Published or Recorded Music
Best Visual Effects
Best Youth Performance - Male
Best Youth Performance - Female
Breakout Performance - Behind the Camera
Breakout Performance - On Screen
Overlooked Film of the Year
- ^ "Phoenix Film Critics Society Awards 2004". imdb.com.