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More NBA
Articles from RotoWire's fantasy archives that mention Alexey Shved's name.
February 27, 2015
DraftKings NBA: Weekend Value Plays
RotoWire's Jerry Donabedian discusses his favorite picks on DraftKings for the upcoming weekend of fantasy basketball.
February 11, 2015
NBA Daily Games Cheat Sheet: Wednesday
With 12 games on the slate, finding the right mix of value plays and high-salaried players is going to be key to winning contests on DraftKings.
January 7, 2015
With 13 games on the slate, finding the right mix of value plays and high-salaried players is going to be key to winning contests on DraftKings.
December 31, 2014
With seven games on the slate, there should be a good mix of low, mid, and high-tier salaries to create interesting lineups with high potential Wednesday.
December 28, 2014
NBA Waiver Wire: Pick-Ups and FAAB for Week 10
With trades and rotation changes shaking up the fantasy landscape on a nightly basis, J.J. Calle has the rundown on all the players you should consider adding for the coming week.
December 20, 2014
Daily Fantasy Basketball 101: Taking the Next Step
RotoWire's Michael Rathburn uses advanced metrics to help identify the best values from FanDuel's fantasy basketball player pool.
December 10, 2014
With 10 games on the slate, finding the right mix of value plays and high-salaried players is going to be key to winning contests on DraftKings.
December 5, 2014
NBA Daily Games Cheat Sheet: Friday
December 3, 2014
There are 10 games on the slate for Wednesday, and with plenty of injury-replacement players avaialable on cheap contracts, it'll be interesting to see some of the top scoring lineups.
November 30, 2014
NBA Waiver Wire: Pickups and FAAB for Week 6
Here with his weekly waiver picks and faab suggestions, J.J. Calle breaks down the players you should consider adding this weekend.
November 16, 2014
NBA Daily Games Cheat Sheet: Monday
With nine games on the slate Monday, finding the right lineup is going to take getting the right mix of high-salaried and low-salaried players. Alex Rikleen
November 14, 2014
November 13, 2014
NBA Daily Games Cheat Sheet: Thursday
With just four games on the slate Thursday, finding good value plays may be more difficult than usual.
October 6, 2014
NBA Auction Strategy Part 6: Points Leagues (ESPN) Rankings and Auction Values
Marc Roberts offers his suggested points leagues rankings and auction values for standard ESPN points leagues.
NBA Auction Strategy Part 5: 8-Category Rotisserie Rankings and Auction Values
Marc Roberts offers his suggested rotisserie rankings and auction values for standard 8-category leagues.
October 5, 2014
NBA Auction Strategy Part 3: H2H Rankings and Auction Values
Marc Roberts and Kyle McKeown explain their suggested head-to-head rankings and offer a cheat sheet for head-to-head auction values.
September 21, 2014
Offseason Moves: Eastern Conference
It's always tough to keep track of all the player movement around the league. Here's a quick breakdown of the Eastern Conference and the team-by-team analysis.
Coaching Tiers 2014: Where Popovich Finishes Last
If minutes are the most important stat in fantasy, then it's important to know which coaches run the most fantasy-friendly rotations and whether last year's trends will continue.
September 19, 2014
NBA Team Previews: Philadelphia 76ers
Michael Carter-Williams has a great opportunity to be the most valuable on a destitute team. He was a top-15 player in head-to-head leagues last season, but can he improve his efficiency to be better in rotisserie?
August 10, 2014
NBA Draft Kit: Position Battles (Atlantic Division)
The Raptors and Nets have their starting lineups pretty well defined, but the Celtics, Knicks, and Sixers should have some healthy position battles in training camp.
February 10, 2014
NBA Injury Analysis: All-Scar Team
Jeff Stotts returns for the third year with his All-Scar Team selections.
February 9, 2014
Hoops Lab: Coaching Changes
With the firing of general manager Chris Grant and head coach Maurice Cheeks this week, fantasy players may be able to capitalize on changes in team dynamics to improve their teams.
December 20, 2013
NBA Blog: Rebound & Rant
When players return early from injuries, it's a truly joyous occasion.
October 8, 2013
NBA Team Previews: Minnesota Timberwolves 2013-14
With new leadership in the front office, the Timberwolves re-signed Nikola Pekovic and Chase Budinger and picked up Kevin Martin in free agency to make a push for the playoffs.
October 7, 2013
NBA Draft Kit: Position Battles (Northwest Division)
Every season, we see a team like last year's Suns throw out an ever-changing rotation that creates a bevy of position battles. Which Northwest Division rosters are tight, and which should you avoid? RotoWire breaks it down.
September 16, 2013
NBA Draft Kit: Coaching Tiers
If minutes are the most important stat in fantasy, than it's important to know which coaches run the most fantasy-friendly rotations and whether last year's trends will continue.
February 26, 2013
The Give and Go: Real and Fantasy Deadlines
Shannon (@RotoShannon) and Kyle McKeown (@RotoWireKyleNBA) have a conversation about the real and fantasy trade deadlines and other NBA topics.
February 24, 2013
NBA Value Meter: Jack Of All Trades
Jarrett Jack is thriving in the Warrior's small-ball system and is making a late push for sixth man of the year. He's averaging 23.0 points, 7.0 assists and 2.3 threes over his last four games is the #5 point guard on this week's meter.
February 17, 2013
NBA Value Meter: Magic Man
Nikola Vucevic is racking up double-doubles on a nightly basis for the Orlando Magic. He's averaging 14.8 points and 13.0 rebounds over his last 10 games and is the second ranked center on this week's meter.
February 10, 2013
NBA Value Meter: Rudy's World
Rudy Gay's fantasy value is on the rise now that he is the #1 option in Toronto. He's averaging 24.3 points, 6.0 rebounds, 3.3 steals and 1.3 threes in his first four games as a Raptor and is the #3 small forward on this week's meter.


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Series 1.5 XK-E - 4.2L Inline 6 with 4 Speed Transmission Jaguar E-type is one of the most eye-catching and curvaceous production cars of... More
***This car is not currently at Fantasy Junction.*** 1961 Jaguar E-Type Roadster s/n 876381, engine no. R3245-9 Black with Black Leather Interior The E-Type was unveiled in March... More
Jaguar E-type Coupe 1969 manual gearbox wire wheels for restoration 1969 Jaguar E-type Coupe with manual gearbox and wire wheels to be fully restored. This... More
1967 Jaguar XKE Roadster. Primrose Yellow with Beautiful Black Leather Interior and Proper Black Vinyl Top. Original 4.2 Liter Twin Cam Engine... More
Chequered Flag International is pleased to offer this 1965 Jaguar E Type Series I Coupe 4.2 Coupe in its original colors of Black with... More
1969 Jaguar E-Type SII Fixed Head Coupe Chassis No. 1R27025 Engine No. 7R7969-9 Stunningly Presented SII 2-Seater Coupe Fully Documented 2-Owner car from New Numbers-Matching 4.2 Litre as per Jaguar Heritage... More
This desirable Series 1 E-Type Roadster is finished in the classic color combination of British Racing Green and finished with tan leather interior. It... More
THIS IS BLEIEVED TO BE A TWO OWNER SINCE NEW ORIGIANAL NORTHERN CALIFORNIA CAR. THE MOST RECENT OWNER HAD THE CAR AS A DRIVER... More
1963 JAGUAR XKE COUPE (FHC) In 1961 Jaguar introduced the E- type to the public and it was shown as a rear wheel drive grand... More
Jaguar E-type S1 roadster flatfloor 1961 restored Beautiful restored, in very good condition, 1961 Jaguar e-type S1 OTS. One of the most wanted models as... More
Jaguar XKE E-type 2+2 coupe 1969 for restoration For sale this Jaguar XKE E-type 2+2 coupe from 1969. Car needs to be fully restored. Engine... More
Jaguars revolutionary E-Type first appeared to a stunned public at the 1961 Geneva Auto Salon. Jaguar boss Sir William Lyons and his chief aerodynamicist Malcolm Sayer paired up to... More
1963 Jaguar E-Type Series I 3.8L Roadster Chassis No. 879848 Engine No. RA2965-9 Here is an exceptionally original and highly favored 3.8L 1963 OTS, that has been sitting in... More
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Chequered Flag International is pleased to offer this 1965 Jaguar 4.2 E Type Series I Roadster in Red with Black and a Black soft... More


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F1 2013: This year's cars in pictures
Brazilian Grand Prix: Pictures from round 20 of the world championship
United States Grand Prix: Pictures from round 19 of the championship
Abu Dhabi Grand Prix: Pictures from round 18 of the world championship
Indian Grand Prix: Pictures from round 17 of the world championship
Korean Grand Prix: Pictures from round 16 of the world championship
- Like mother, like son! Charlize Theron and little Jackson hold hands while coordinating in sweatpants on lunch outing
- Indulging her sweet tooth! Dressed down Emmy Rossum treats herself to a box of cupcakes The 28-year-old actress cut a fashionable figure
- If you've got it, flaunt it! Miranda Kerr bares toned midriff in crop top and tight jeans as she steps out in LA One of the most envied bodies in the world
- Hollywood hunk! Hugh Jackman looks dapper in buttoned down suit as he steps out in Paris for photo call of new film Chappie with co-star Sigourney Weaver
- Zoe Saldana displays trim figure in black shirt dress and sexy over-the-knee boots... three months after welcoming twin boys
- 'I put on a dress and it was cellulite central': Jessie J opens up about her 'flaws and insecurities'... and how she 'prays to God' about having children
- 'I run a lot... but I can also throw down a pint of ice cream!' Hannah Ferguson wows in lacy lingerie as she's revealed as the new face of Triumph
- Rebel Wilson cuts a casual figure in a hooded jacket and plunging black jumpsuit as she makes her way through the airport On the go again
- Robert De Niro cuts a $6.4million cheque to the IRS after a lien was put on his New York condominium to ensure he paid his taxes A hefty bill
- What happened to your knee? Elle Fanning wears a bandage on her leg as she steps out in Los Angeles 16-year-old seemed unfazed
- Her own Disney princess! Coco Rocha covers bump in black dress as she announces she is having a girl at Cinderella-inspired clothing launch
- A rock star AND a gentleman: The touching moment Foo Fighters frontman Dave Grohl seeks out a blind fan in the front row and hands him a rare memento
- How does she do it? Emily Blunt looks amazing in a casual T-shirt and jeans while out to lunch It appears she never has an off day
- She's really starting to show! Ashlee Simpson reveals growing baby bump at lunch with husband Evan Ross Expecting second child after whirlwind marriage
- Who's paying £34million to blast Sarah Brightman into space? And no, it's not her old flame Andrew Lloyd Webber... From Kazakhstan
- Ethan Hawke gets intimate with Greta Gerwig as they walk hand-in-hand while filming scenes for Maggie's Plan in NYC
- Kanye West BREAKS DOWN during radio interview as he discusses the death of fashion professor Louise Wilson Friend died last May
- Jordin Sparks is spring ready as she flashes her toned midriff in floral-patterned trousers and a black crop top Luckily, she's in warm Los Angeles
- Step back in time! Kylie Minogue, 46, reveals flawless youthful skin in make-up free photo as she slicks back hair for shoot Not preened
- Pregnant Abbey Clancy bundles up with an oversized scarf and shades as she treats Sophia to a shopping trip with the family Expecting No.2
- Leather overload! Margot Robbie is swamped by heavy black layers as she has a hair-raising day in New York City Wrapped up warm
- SEBASTIAN SHAKESPEARE: Kelly Hoppen mocks Madonna's tumble after suffering cape wardrobe malfunction Brazen interior designer
- House Of Cards star Kate Mara is crowned Max Mara's new Women in Film Face Of The Future succeeding 2014 winner Rose Byrne
- Younger, slicker... and a bit like Paris Hilton: First look at Lady Penelope as she joins Alan 'Brains' Carr and Noel 'Parker' Gallagher for new Thunderbirds
- Molly Sims reveals how she has gained only HALF the baby weight compared to her first pregnancy in new interview ahead of second birth
- BBC chief praises Wolf Hall despite losing 1.6million viewers in five weeks Director-general Tony Hall calls the Tudor epic the BBC 'at its very best'
- He's got the blues! Canadian rapper Drake dresses in an all-denim outfit as he and his big and burly entourage enjoy a meal at Bondi Icebergs
- Gingham style! Olivia Wilde glams it up in check dress as she displays her bare legs in freezing NYC She'd just landed in the city from London
- Going undercover? James Spader looks dapper in a navy fedora and matching wool coat as he films scenes for The Blacklist
- Kelly Brook shows off her ample assets as she dons plunging pink mini dress in teaser trailer for new TV show One Big Happy That'll win some fans
- BAZ BAMIGBOYE: Ridley Scott? He's out of this world, says Jessica Chastain praises film-maker for his efforts in creating choice roles for women
- The Second Best Exotic Marigold Hotel: Dame Judi's expats don't overstay their welcome in a sweet, sentimental sequel A good follow-up
- The Boy Next Door review: An absolute scream... shame it's supposed to be a tense psychological thriller J.Lo has another flop on her hands
- Quiet on the set! Jodie Foster bundles up for the cold as she directs the first day of filming for Money Monster in New York City
- Three generations! Jordana Brewster takes son Julian for a family stroll with her dad Aldon On Thursday the actress was playing the role of doting mum
- Power players in the making! Martha Stewart shares throwback photo with Oprah Winfrey from over 30 years ago Loving the big hairstyles...
- She's got specs appeal! Jennifer Lawrence goes make-up free in stylish glasses as she braves the snow in Boston to walk her dog
- Geordie Shore star Holly Hagan posts busty selfies to her Instagram account as she teases her fans with her perfect pout Very racy snap
- Blur vs Noel? It's a new Britpop battle: ADRIAN THRILLS reviews the latest albums in the world of rock and pop
- She sure is enjoying motherhood! Drew Barrymore goes make-up free and in ripped jeans to take daughters for pony rides in LA with an old friend
- As critics and viewers hail the spin-off of crime drama Breaking Bad here's a guide to Better Call Saul that'll get you hooked Saul Goodman is back
- She Sher-looks good! Natalia Vodianova works detective-inspired belted cape coat for dinner with friends Russian model
- Conan O'Brien reveals he once pranked Bill Cosby into believing he won a lifetime achievement award from Harvard - and the comedian showed up in a tuxedo to accept
- What would Lucy say? Louis Smith posts EXTREMELY saucy bathroom mirror selfie to show off rippling gymnastics torso Currently in training
- Mr Grey will message you now: Whiplr, a new Fifty Shades-inspired dating app, helps BDSM fans connect with kinky play partners
- 'I'm not a real working mother': Kelly Clarkson admits she doesn't find juggling parenthood and her career difficult thanks to the help of a nanny
- PIERS MORGAN: Falling off the stage, Madonna, is God's way of telling you you're too old to cavort like a hooker What a spectacle
- Turning the courtroom into a song and dance! Robin Thicke performs piano medley in the middle of Blurred Lines trial to prove he did not steal from the late Marvin Gaye
- An intimate look at their married life: Reese Witherspoon gets on her tippy-toes to fix husband Jim Toth's tie while at home before the Oscars
- Dakota Johnson goes retro in a flared denim jumpsuit as she heads to SNL rehearsals ahead of her hosting debut
- BAZ BAMIGBOYE: Now Queen Helen puts Blair in the hot seat Helen Mirren's Queen starring in Broadway production of The Audience
- Christina Aguilera follows up her Britney Spears impression with flawless impersonation of Kim Cattrall from Sex And The City Back-up career?
- Shining bright! Gigi Hadid oozes supermodel confidence as she sports vibrant street wear designs at Moschino Milan Fashion Week show
- How to put royal PR men in a spin... give Prince Harry a video camera: CHRISTOPHER STEVENS reviews last night's TV
- Did you plan ahead? Vicky Pattison and Casey Batchelor co-ordinate their outfits perfectly as they leave London hotel At the May Fair Hotel
- Truly outrageous! Check out the first still from Universal Pictures' live-action Jem and the Holograms movie Hitting US cinemas on October 23
- 'Magical day!' Gisele Bundchen shares heartwarming photo of wedding day as she celebrates sixth anniversary with husband Tom Brady
- Showing their support! Calvin Harris and Lionel Richie work casual ensembles as they join Emilia Fox at charity launch For The Prince's Trust
- Liv Tyler and Dave Gardner look overjoyed to bring their two-week old son home for the first time after premature birth Precious boy Sailor
- Oklahoma! Oh, what a beautiful (and corny) musical! The most deliciously brainless of all musicals says PATRICK MARMION
- Catch Me Daddy: Runaway love on the moors in the Wolfe brothers thoroughly accomplished debut BRIAN VINER reviews stirring new film
- Shaw's a bore with too much jaw-jaw: First night review of Man and Superman An insufferable windbag or witty presenter of big questions
- No jealousy here! Lenny Kravitz, 50, is 'good friends' with Lisa Bonet's new husband Jason Momoa, 35, according to daughter Zoe
- We're too wary of violence on women but never offended by assaults on men, says TV writer Sally Wainwright
- 'I have the perfect family!' Defiant 51-year-old single mother hits back at critics who slammed her decision to give birth to a second child
- EXCLUSIVE: Giuliana Rancic's Zendaya jibe was SCRIPTED by Fashion Police writers - and no-one at E! network complained before show aired
- Keeping up with Kim Kardashian! Socialite Brittny Gastineau steals BFF's style with smoky eye make-up, a slick updo and leather trousers
- Doutzen Kroes looks effortlessly stylish in fitted tweed jacket and leather trousers as she and Kendall Jenner hang out at Milan Fashion Week
- Divorce And The City: Sarah Jessica Parker returns to the streets of New York to shoot new HBO comedy It's the sight SATC fans have been waiting for
- 'I got new girls, new problems': Cody Simpson debuts latest song at charity concert... but his girlfriend Gigi Hadid may not like the lyrics
- EXCLUSIVE: 'She was always pretty special': Margot Robbie's childhood sweetheart is a Gold Coast builder who gave the Hollywood starlet her first kiss
- My kid is my stylist! Cornish mother starts global fashion craze for mums being dressed by their children after she allows daughter to pick out her school run outfit
- Is this the most desperate publicity stunt yet? Mark McGrath online death hoax orchestrated to promote season premiere of his TV show
- 'They've cried together about this': Kris Jenner lends support to ex Bruce after fatal car crash... following news he likely won't be prosecuted
- It Follows: The scary demon who gives love a bad name American suburbia that movie-makers love filling either with serial killers, or malevolent spirits
- 'I'm a freaky voyeur!': Will Smith's wife Jada Pinkett-Smith admits she enjoyed watching his sex scenes with Margot Robbie Will doens't share feeling
- 'You can leave now!' Farrah Abraham shunned by co-stars Maci Bookout, Amber Portwood and Catelynn Lowell in first trailer of Teen Mom OG
- 'That's mother fluffin' awful!' Nasty Gal markets bizarre $540 dress which makes the wearer look as though they are wearing nothing but furry pom poms
- 'We're Angels, not divas!' Victoria's Secret models Alessandra Ambrosio and Elsa Hosk on the lengths they will go to in order to get the perfect swimsuit shots
- 'I'm a grandma - my bedtime is 10pm': Model Gigi Hadid, 19, admits to avoiding the Hollywood party scene as she reveals details about her daily beauty routine
- What would Yvette say! Etiquette expert on why Ed Balls' confession to being a 'long, slow lover' in bed is contributing to 'long, slow murder of chivalry'
- Britain's top female surfer gives birth to son eight weeks early, just TWO days after posing for maternity photo-shoot Reggie was just 4lb 1oz
- Dressed to impress! Princess Mary plays up to her daring side as she dons a leather vest, pencil skirt and knee-high boots to carry out royal duties in Denmark
- He's a lucky guy! Nick Lachey is feeling the love from wife Vanessa on romantic date without their children Loved up couple couldn't resist a smooch
- Ashley Benson is a blushing winter bride in NYC... but it's just to shoot scenes for new comedy with co-star Shiloh Fernandez
- 'I projectile vomited 1.8 kilos of spaghetti': Margot Robbie confesses to less than elegant display in eating contest during Graham Norton Show
- The Devil Wears Lycra: Emily Blunt looks lean in her workout gear as she stops by the gym in Beverly Hills Looked radiant
- Mexican singer Ariel Camacho dies in car crash at the age of 22 while promoting El Karma album Fronted band Los Plebes del Rancho
- 'We love you - forever': Tyra Banks 'deeply saddened' over murder of 'vivacious' America's Next Top Model contestant, 19, shot dead in triple homicide
- 'It was extremely awkward!' Margot Robbie reveals she got caught stealing as she prepared for her con artist movie Focus Caught red-handed
- Nothing can stop the remarkable Arnold Schwarzenegger reboot as the Hollywood star promises he'll be back for SIXTH Terminator sequel
- 'God puts us in situations that are unexplainably difficult': Selena Gomez shares inspiring Instagram message as she drops by salon
- 'Taylor Kinney you're a lucky man!': Sophia Bush gushes over her Chicago P.D. co-star's new fiancee Lady Gaga in touching Instagram post
- 'He's always loved the ladies': Bruce Jenner 'plans on being a lesbian' once he completes gender reassignment Said to be transitioning
- Baby number two! Dallas star Leonor Varela, 42, and producer Lucas Akoskin welcome a daughter with an out-of-this-world name It's Luna Mae. (Luna means moon in Spanish)
- Keith Urban reacts with glee when American Idol hopeful Joey Cook performs one of his hits with an accordion Interesting take
- The rise of crazy cat MEN? Photographer aims to change society's 'sexist' views about feline ownership with powerful portraits of guys with their beloved pets
- Kim Kardashian accentuates her curves in a black belted kimono dress as she steals a kiss with husband Kanye West following his BRITs appearance
- EXCLUSIVE: Taylor Kinney's ex woke to his late night call but what she heard were kissing sounds and breathy whispers. Her man was cheating and the woman was Lady Gaga
- 'South Sydney is more than just a team...it's a movement': Russell Crowe shares passion about his beloved club after snubbing Oscars for World Club Challenge
- Chasing the sun: A Bikini A Day model Natasha Oakley ditches rainy Sydney summer for California winter and shows off toned abs in a two-piece
- Sale of Liz Taylor's $8m Taj Mahal diamond at center of dispute between the dead star's estate and the auction house that wants its money back
- The ones who didn't bite! Meet the entrepreneurs whose companies are thriving after rejecting Shark Tank deals Annual revenue for The Smart Baker nears $1m
- Fast-growing family! Richard Branson reveals his son Sam has welcomed a baby girl... just two months after daughter Holly gave birth to twins
- TOWIE beauty Danielle Armstrong enjoys lunch date with boyfriend James Lock in skintight jeans and funky paisley print top Watch out Brentwood!


text:
My FRED
- eci x 425
- private industries x 2,616
- inflation x 4,723
- workers x 6,507
- salaries x 7,482
- wages x 7,870
- sa x 49,977
- quarterly x 50,372
- bls x 83,740
- nation x 137,021
- usa x 147,289
Related Categories
Need Help?
Employment Cost Index: Wages & Salaries: Private Industry Workers
On April 26, 2006, The Employment Cost Index will convert to the 2002 North American Industry Classification System (NAICS) and the 2000 Standard Occupational Classification System (SOC). In addition, several computational changes will be introduced, including rebasing all series to December 2005=100 from June 1989=100, the introduction of new employment weights and seasonal adjustment factors.
For more detailed information on NAICS and SOC, including background and definitions, please see the Bureau of Labor Statistics (BLS) websites: http://www.bls.gov/bls/naics.htm and http://www.bls.gov/soc/home.htm.
Source: US. Bureau of Labor Statistics
Release: Employment Cost Index
US. Bureau of Labor Statistics, Employment Cost Index: Wages & Salaries: Private Industry Workers [ECIWAG], retrieved from FRED, Federal Reserve Bank of St. Louis https://research.stlouisfed.org/fred2/series/ECIWAG/, March 6, 2015.


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Absolutely astounding quality optics and photos. Easily enlarges to 8x10 with pinpoint clarity. It is 1.3 megpix but gets better clarity and resolution compared to some of my friend's 3.0 MP. 3x optical zoom is perfect. I found that the quality is particularly sharp on relatively inexpensive matte finish, 90-92 brightness, 35-37 weight paper. Very happy with this camera! Use SHQ setting for most shots. Problems: Read the manual over twice. The INDEX to the manual is in a strange ...
View review in forums Leave a comment on this reviewOlympus D-450 Zoom (C920Z)
Announced Jul 31, 1999
1 megapixels | 1.8″ screen | 35 – 105 mm (3×)
Man this camera is a blast. I have 8 Nimh bateries which i switch in and out of the camera. They haven't died it's just that i don't want to be caught with dead batteries. The power consumption is fantastic. I can take hundreds and hundreds of pics all with the LCD and half with flash. I highly recomend the camera it is so easy to use and it is packe with features
View review in forums Leave a comment on this review


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The Mind of a Chef Taps Sean Brock and April Bloomfield for Season Two
The Husk and Spotted Pig chefs are getting some headspace.
The Husk and Spotted Pig chefs are getting some headspace.
"A pretty ingenious way to drink coffee in the morning."
The trio of hugely famous chefs will prepare a $190 per-person five-course menu.
Expect the Momofuku chef to go into hiding next month.
Maybe the second one will land in Philly.
Do you really think David Chang's former top lieutenant would bother coming here is he thought we were all a bunch of mouth-breather, cheesesteak-eating rubes?
David Chang's former right-hand man says his forthcoming restaurant will be American rather than Asian.
Yes, burn sauce was involved.
The two chefs will riff on Italian cuisine through eight courses.
That's a lot of salt cod fried rice and Kung Pao pastrami.
The Echo Park locavore avoids being just "a parody of 2012 and of everything Chang was deriding in his figs-on-a-plate comment."
The Momofuku team will host three benefits around the city today and tonight.
And River Cafe might have gotten the worst of it.
David Chang will party down with Joël Robuchon.
Step into a world of chef-madness. On PBS, of course.


text:
Lighten up
Running Time: 8 mins. | |
Genre: Comedy, Drama |
John Viener
All Cast & Crew >>
Summary:Bo, an expectant father, is taking his best friend the doctor. On the way, he has a discussion on his situation in life, and realizes how little he knows his friend and himself.


text: Have an app to suggest? We can't promise to list everything, but fill out the information below and we'll have a look. App Name * App Description * Keep it to two or three sentences. Free or Not? * Free Not Free App Icon URL App Platform(s) For each platform supported by your app, enter the URL. If your app does not support that platform, leave the URL space blank. iOS Android Windows Mobile Web/HTML Other Developer Information Developer Name * Developer E-mail * Which BART Developer Services do you use? (Check all that apply) App Map Geospatial Data GTFS GTFS-RT Real BART API RSS Feeds None of these


text:
The Differentiation of Talent: Rethinking Performance Management
Publication Date:Oct 13, 2005Discipline:Human Resource ManagementSource:Harvard Business Press Chapters |
Product number:9889BC-HCB-ENG Length:32p |
English Hardcopy Black & White
Also Available in:
English Hardcopy Black & White | $ 6.93
Truthfully evaluating the quality of people's performance-and their potential-allows organizations to make critically important talent management decisions. Unlike conventional performance appraisal, forced ranking is a management process that requires managers to assess how well people performed compared with how well other people performed. It both demands and guarantees differentiation.
This chapter is excerpted from "Forced Ranking: Making Performance Management Work."
learning objective:
To describe how forced ranking creates a culture of accountability and differentiation.
subjects covered:
Accountability; Employee development; Leadership development; Performance appraisals; Performance management


text:
Babycook Classic
Babycook Classic
A patented compact countertop appliance that functions as a steamer, blender, warmer and defroster to prepare fresh, healthy meals for baby. Quickly steam cook vegetables, fruits and meats in 15 minutes or less, while preserving their vitamins and flavors. Puree and blend food to the desired consistency making it super smooth, chunky or anywhere in between for baby. Clean up is quick and easy with a top-rack dishwasher safe bowl and basket. Comes with a spatula and recipe booklet.
- Prepare fresh, tasty and healthy meals for babies and toddlers in 15 minutes
- Makes cooked and pureed from from raw, including fruits, vegetables, meat or fish
- Make any stage baby or toddler food from purees to solids
- Preserve vitamins and nutrients
- Bowl capacity 3.7 cups / 800 ml
- BPA, Lead and Phthalate free
- Designed in France
Dimension: 9 x 8 x 5.5 inches / 23 x 20 x 14 cm
Weight: 3.75 lbs / 1.7 kg
Material: Bowl: Polyphenylsufone (PPSU) Cooking Basket: Polypropylene Reservoir Interior: Ceramic Coated Steel
Manufactured In: China


text:
byRob Wright on
19. Herve Tardy
VP, GM, Eaton
Eaton has expanded from its power management base into new software and virtualization markets with products such as the company's Intelligent Power Software Suite. At the head of some of those moves is Tardy, who's taking Eaton's Distributed Power Quality Business Unit to new heights.
Live At XChange Solution Provider 2015
XChange Solution Provider 2015 is finally upon us and the timing couldn't be better. The premier channel event is happening March 1-3 in Dallas, bringing together 225 solution provider decision makers from across North America. CRN is at the event to provide news, analysis and a firsthand take from partners.
Here are 10 recent searches by CRN visitors.
Cloud 100


text:
You'll find it on the News and Events section of the Callaghan Innovation website.
In association with Callaghan Innovation, the Riddet Institute announces the April 2013 lecture series: Food & Nutrition.
Industrial Research Ltd chairman Michael Ludbrook has praised outgoing IRL Chief Executive Shaun Coffey for tranforming the Crown Research Institute into a national asset that will be the crown jewel of Callaghan Innovation.
Shaun Coffey, the retiring CEO of Industrial Research Ltd (IRL), has congratulated the newly-announced directors of Callaghan Innovation on their appointments.
The Callaghan Innovation Bill, which establishes a new high-tech HQ for manufacturing and services firms, today passed its third and final reading in Parliament.
After careful reflection, I have decided to pursue new career directions. In the last week the position of Industrial Research Ltd (IRL) as a significant contributor to the NZ innovation system has been further acknowledged through a series of Awards and Medals, including one of the PM's Science Prizes. IRL is now well recognised for its work with industry. I am confident that I will be leaving IRL in a sound state and well positioned for the future.
New firms need to invest in R&D to gain market share. Established firms need to invest in innovation to lead the market or to protect their slice of the pie. But what type of R&D? How do we classify what will work and what won't? There is no straight answer to the innovation mystery.
Converting a powdered fertiliser into an on-farm, easily spread 2-4mm granule requires adding just the right amount of water into a revolving hopper.
While many school children and adults often question the value of learning mathematics, the ability to understand and manipulate numbers and equations through complex models provides answers that would be almost impossible to obtain otherwise.
The development of a low-cost tool that verifies intravenous drugs at the point of administration might, at first glance, appear to have little to do with applied mathematics.


text:
Originally Posted by DREW WILEY Go down the list of the five richest men in the world. At least two of them have been clients of mine in the last week, maybe three of them. Drew, next time you meet these guys, be sure to tell them it's such a pity they can't afford a print by Cliveh.
cliveheritagetilley.co.uk The contemplation of things as they are, without error or confusion, without substitution or imposture, is in itself a nobler thing than a whole harvest of invention Francis Bacon


text:
I accidentally purchased Burton salts as opposed to gypsum at the LHBS recently, and on the label it says "contains papain." So I was perusing the web, looking for details on the use of papain in brewing, and found this gem:BEER HAS EVERYTHING??? Be sure to read it all; the farther in you go, the better it gets.
On a brewing hiatus. Will get back into the fray eventually, methinks...
im speachless....its like reefer madness but for beer.
Wow. A few partial truths with some unresearched garbage. Did they actually research what dextrin is and where it comes from. This is why I don't like some extreme bible thumpers.
Make Beer, Not War.
Okay. I get it. They don't like our beer. They fain at our additives. So I say let them drink GOD's life water from the stagnant pond and soon they will see their folly.
They dont like our beer, I dont like their god.
as a christian this appalls me the ignorance of so many Christians is very frustrating they quote scriptures but forget that jesus's first miracle was to turn water into wine i go to church every sunday i run the sound board and from time to to time have had a beer with my pastors at a bbq
Anyone can play this game.
ok, to shoot a HUGE hole in that crap. dont catholics drink wine as "the blood of Christ"? My knowledge of alcohol is its not completely healthy for you, but frankly nothing is, yet its only REALLY harmful to you in large amounts. the lesson? drink in moderation or just enjoy your drink, you're not gonna live forever anyways. when I say "that crap" I mean the site linked in the original post.
So who will be the first to claim this graphic as their avatar?


text:
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text:
Insulin aspart (IAsp) and its biphasic preparations BIAsp50 and BIAsp70 (containing 50% and 70% IAsp, respectively) have distinct glucose-lowering properties as compared to human insulin (HI). We investigated whether this affected the circulating IGF-system which depends on the hepatic insulin exposure.
In a randomized, four-period crossover study, 19 patients with type 1 diabetes received identical doses (0.2 U/kg sc) of IAsp, BIAsp70, BIAsp50 and HI together with a standardized meal. Serum total IGF-I and IGFBP-1 to -3 were measured by immunoassays for nine hours post-prandially. Bioactive IGF was determined by an in-house, cell-based IGF-I receptor kinase activation (KIRA) assay.
Despite marked differences in peripheral insulin concentrations and plasma glucose, the four insulin preparations resulted in parallel decreases in IGFBP-1 levels during the first 3 hours, and parallel increases during the last part of the study (3–9 hours). Thus, only minor significances were seen. Insulin aspart and human insulin resulted in a lower area under the curve (AUC) during the first 3 hours as compared to BIAsp70 (p = 0.009), and overall, human insulin resulted in a lower IGFBP-1 AUC than BIAsp70 (p = 0.025). Nevertheless, responses and AUCs of bioactive IGF were similar for all four insulin preparations. Changes in levels of bioactive IGF were inversely correlated to those of IGFBP-1, increasing during the first 3 hours, whereafter levels declined (-0.83 ≤ r ≤ -0.30; all p-values <0.05).
Total IGF-I and IGFBP-3 remained stable during the 9 hours, whereas IGFBP-2 changed opposite of IGFBP-1, increasing after 3–4 hours whereafter levels gradually declined. The four insulin preparations resulted in similar profiles and AUCs of total IGF-I, IGFBP-2 and IGFBP-3.
Despite distinct glucose-lowering properties, the tested insulin preparations had similar effects on IGF-I concentration and IGF bioactivity, IGFBP-2 and IGFBP-3 as compared to HI; only small differences in IGFBP-1 were seen and they did not affect bioactive IGF. Thus, insulin aspart containing preparation behaves as HI in regards to the circulating IGF-system. However, bioactive IGF appeared to be more sensitive to insulin exposure than total IGF-I. The physiological significance of this finding remains to be determined.
Trial registration
Insulin; Insulin analogue; IGF; IGFBPBackground
In patients with type 1 diabetes (T1D), insulinopenia in the portal circulation leads to alterations of the growth hormone - insulin-like growth factor I - insulin-like growth factor binding protein (GH - IGF-I - IGFBP) axis [1], including GH hypersecretion, reduced circulating levels of IGF-I and IGFBP-3, and elevated levels of IGFBP-1 and -2 [2-4]. Due to the insulin antagonizing effects of GH and the insulin sensitizing effects of IGF-I, these alterations are likely to have a negative effect on whole body insulin resistance [5,6] and they may also contribute to the development of long-term complications. Thus, in T1D one hypothesis has linked the augmented secretion of GH with the development of diabetic retinopathy [7] and nephropathy [8]. Supportive of this, intensified subcutaneous insulin therapy can improve metabolic control, return changes in the GH-IGF-axis towards normal and decrease progression of diabetes complications in patients with T1D [9]. However, it is worth to realize that not even excellent glycemic control can fully normalize the GH-IGF-I-IGFBP axis [2].
Insulin aspart, a rapid-acting insulin analogue, has been employed in intensified insulin therapy for many years. After subcutaneous injection, insulin aspart is absorbed faster and eliminated more quickly than human insulin, thus it has a more physiological insulin profile [10]. The pharmacokinetic profile of insulin aspart can be extended by combining soluble insulin aspart with protamine insulin aspart, but even this formulation has a faster onset of action than human insulin. Thus, a previous clinical study demonstrated that insulin aspart as well as mixtures of soluble and protamine insulin aspart (i.e. BIAsp70 and BIAsp50 which contains 70% and 50% rapid-acting insulin aspart and 30% and 50% protamine insulin aspart, respectively), are absorbed twice as fast as human insulin and associate with higher peak concentrations [11]. Based on these observations we hypothesized that the distinct peripheral insulin profiles obtained with the abovementioned insulin preparations could translate into distinct hepatic exposures to insulin and in this way affect the liver production of IGF-I and IGFBPs differently. However, this assumption has not been tested under controlled and standardized circumstances.
The aim of the present trial was to compare the serum profiles of IGF-I and the IGFBPs after a subcutaneous injection with equal doses of insulin aspart, BIAsp70, BIAsp50 or human insulin. In particularly, their effects on the insulin-regulated IGFBP-1 had our interest, as differences in IGFBP-1 may lead to secondary changes in bioactive IGF.
This open-label, randomized, four-period crossover study was approved by the central Denmark region committees on health research ethics and the Danish Medical Agency. The study was carried out according to the Declaration of Helsinki and the principles of Good Clinical Practice. Written informed consent was obtained from all the participants before any study related activities. Findings related to the pharmacokinetic and pharmacodynamic profiles of human insulin vs. the three different insulin aspart preparations have recently been published elsewhere [11].
Patients of both genders with T1D, aged ≥ 18 years, with HbA1c of 53–108 mmol/mol (7-12%) and body mass index (BMI) of 18–35 kg/m2 were recruited. Patients had to have the clinical diagnosis of diabetes before the age of 40 years and to be treated with any insulin regimen for ≥ 12 months at a daily insulin dose ≥ 0.4 U/kg. Exclusion criteria included patients who had allergy to investigational insulin, recurrent major hypoglycemia (defined as >2 severe hypoglycemic episodes within the last 12 months), acute myocardial infarct < 12 months or severe heart insufficiency, abnormal liver and kidney function (estimated by routine laboratory biochemical testing), pregnancy or breast-feeding. Some patients received other prescribed drugs than insulin; however, this medication remained unaltered during the entire study.
The study comprised four study visits (at least one week apart), where insulin aspart, BIAsp70, BIAsp50 or human insulin were administrated in random order. By choosing a crossover design where each patient served as his or her own control, we aimed to reduce the influence of inter-individual differences in regards to for instance insulin sensitivity. Patients reported to the clinical research unit at 9:00 p.m. on the night prior to the profile day. They were thoroughly instructed to inject the last dose of basal insulin at least 24 hours before administration of the study insulin. During the overnight fast, intravenous infusions of isotonic glucose and insulin were administered to maintain blood glucose values between 5 and 8 mM and by this, to attain a comparable baseline glucose level prior to study insulin injection. Infusions were commenced at 10:00 p.m. and ended at 8:00 a.m. Soluble human insulin (Actrapid®, Novo Nordisk) was infused during the night prior to the morning injection of insulin aspart preparations. Conversely, insulin aspart was infused before the morning injection of human insulin. Blood glucose was measured every 30 min over night. Before the insulin injection, the glucose values had to be within the defined range for at least 30 min. In the morning of the profile day, a single dose (0.2 U/kg) of either insulin aspart, BIAsp70, BIAsp50 or human insulin (Actrapid®, Novo Nordisk) was injected subcutaneously at the abdomen. Insulin aspart preparations were injected immediately before the meal, which started at 8 a.m., whereas human insulin was injected 30 min before the meal. The standardized meal contained 3360 kJ fat, carbohydrate and protein and was finished within 15 min. From 8:00 a.m. (baseline), blood samples were drawn hourly for determination of serum concentrations of IGFBP-1 and IGFBP-2, while total IGF-I, bioactive IGF and IGFBP-3 were measured at 0, 3, 6, and 9 hours.
Blood glucose was measured every hour with the plasma glucose meter (Ascensia Contour, Bayer) for safety assessment and more often if needed. Patients were treated with oral glucose (equal to 40 g glucose) or intravenous injection of 10% glucose if the blood glucose measurement was below 3.1 mM. Study procedures were discontinued when the patient's glucose measurement exceeded 16.0 mM.
Laboratory assessment
All the variables were analyzed in serum. Samples were stored at -80°C until analysis.
Total IGF-I and IGFBP-3 levels were determined by commercial chemiluminescence immunoassays on the IDS-iSYS multi-discipline automated analyzer (Immunodiagnostic Systems Nordic SA, Denmark) according to the manufacturer's protocol, as recently published [12,13]. Limits of detection for total IGF-I and IGFBP-3 were 4.4 μg/l and 50 μg/l respectively.
IGFBP-1 was determined by an in-house time-resolved immunofluorometric assay (TR-IFMA) with slight modifications as recently described [14]. IGFBP-2 was determined by a validated in-house time-resolved immunofluorometric assay (TR-IFMA) as previously described [15]. The IGFBP-1 and -2 assays have intra- and inter-assay CVs averaging <5% and <12%.
Bioactive IGF was determined by an IGF-I kinase receptor activation (KIRA) assay based on human IGF-I receptor gene-transfected embryonic renal cell as described by Chen et al.[16] with slight modifications [14]. In brief, transfected cells were stimulated for 15 min at 37°C with either IGF-I standards (WHO 02/254) or diluted serum. After cells were aspirated and the cells lysed, the crude cell lysates were transferred to a TR-IFMA assay to detect the concentration of phosphorylated IGF-I receptors. The KIRA assay also detects IGF-II and pro-IGF-II activation of the IGF-IR with a cross-reactivity of 12% and 2%, respectively. Although the majority of the KIRA assay signal obtained in serum without any doubt originates from an IGF-I induced activation of the IGF-IR, IGF-II is likely to participate and accordingly, the output of the KIRA assay has been named "IGF bioactivity". By contrast, the cross reactivity of proinsulin, insulin and insulin analogues were less than 1%. The KIRA assay has a detection limit < 0.1 μg/l, and intra- and inter-assay CVs of <7% and <15%, respectively.
Statistical analysis
A power analysis showed that 19 completed subjects would be required to yield a statistical power of 90% to detect an absolute difference of 10 μg/l between the minimum concentrations of IGFBP-1. Thus, to allow dropouts we invited 24 subjects to participate. Statistical analyses were performed using IBM SPSS Statistics version 20.0 (IBM Corp., Somers, NY, USA). Komogorov-Smirnov test was used to test for normal distribution. Natural logarithmic transformation was performed to improve the distribution of raw data. Area under the concentration-time curve (AUC) was calculated by the trapezoidal rule for the time intervals 0–3 hours (AUC0–3), 3–6 hours (AUC3–6), 6–9 hours (AUC6–9) and for all 9 hours (AUC0–9). The differences in Cmax, Cmin, tmax, tmin and AUCs were determined using analysis of variance (ANOVA) with treatment as a fixed factor and patient as a random factor. The baselines levels were used as co-variables in the ANOVA analyses for the AUC0–3 and AUC0–9. If a patient discontinued earlier than planned, ANOVA tests were only performed for his/her completed periods. If the ANOVA was significant, the difference between treatments was examined statistically by using the Bonferroni method. Analysis of time-related effects among groups was performed using repeated measures ANOVA. Linear correlations were used to assess relationships between measured variables. P values <0.05 were considered statistically significant.
Nineteen patients (15 men and 4 women), aged 40.7 (22–63) years (mean and range), with a BMI of 25.5 (20.6-30.3) kg/m2, a duration of T1D of 20.9 (3–47) years and a present HbA1c of 66 (53–84) mmol/mol [8.2 (7.0-9.8)%] underwent all four study visits. The profile day was ended after six hours of insulin injection for three patients with the insulin aspart treatment and for one patient with human insulin, because their glucose levels exceeded 16.0 mM as defined by study protocol. The rest of the patients completed the nine hours experimental period of all four study visits.
Insulin and glucose
Figure 1a and b illustrate the insulin and glucose profiles during nine hours period, as recently published [11]. In brief, results showed that the insulin and glucose profiles following sc injection of human insulin differed significantly from those of the insulin aspart preparations. BIAsp50 demonstrated the greatest similarity to human insulin as regards pharmacokinetic and pharmacodynamic profiles [11].
Figure 1. Insulin and glucose profiles. Serum insulin concentration (a) and plasma glucose concentration (b) during 9-hour treatment with insulin aspart (open circles), BIAsp70 (black rectangles), BIAsp50 (open rectangles) and human insulin (black circles). The arrow indicates human insulin injection time, and the vertical dotted line indicates the time of meal. Serum insulin and plasma glucose profiles are illustrated as mean levels (reprinted with permission from Diabetes Technology & Therapeutics).
Baseline IGF levels
At baseline, serum concentrations of total IGF-I, bioactive IGF and IGFBP-1 to -3 were comparable among the four treatment days (Table 1).
Table 1. Results of IGF parameters
Changes in IGF levels during the nine hours of study
None of the investigational insulin preparations changed serum total IGF-I levels from baseline (Figure 2a). Similarly, maximum and minimum concentrations of total IGF-I were similar for insulin aspart preparations and human insulin. There were no significant differences in the AUCs of total IGF-I in any time interval during the study (Table 1).
Figure 2. IGF parameters profiles. (a) Serum total IGF-I concentration, (b) bioactive IGF concentration, (c) IGFBP-1 concentration, *P < 0.01 as BIAsp50 compared with insulin aspart and human insulin for AUC0–3; **P < 0.05, as BIAsp50 compared with human insulin for AUC3–6; ***P < 0.05, as BIAsp70 compared with human insulin for AUC0–9.(d) IGFBP-2 levels and (e) IGFBP-3 levels during 9-hour treatment with insulin aspart (open circles), BIAsp70 (black rectangles), BIAsp50 (open rectangles) and human insulin (black circles). For clarity, serum concentrations are illustrated as mean levels only.
For all four insulin preparations, serum IGF bioactivity increased during the first three hours. As compared to baseline levels, these increases were significant following insulin aspart (+18%) and human insulin (+28%), and insignificant for BIAsp70 (+9%) and BIAsp50 (+12%) (Figures 2b and 3a). By contrast, bioactive IGF levels decreased significantly (all p-values <0.05) during the last three hours, irrespective of study insulin (Figures 2b and 3a). In regards to Cmax, Cmin and the AUCs, no statistical significant differences in bioactive IGF were found between the four insulin preparations (Table 1).
Figure 3. Changes in IGF bioactivity and IGFBP-1. IGF bioactivity (a) and IGFBP-1(b) levels during 0–3 hours and 6–9 hours. Asterisks indicate that significant change was found in comparison with previous level (p < 0.05).
For all four insulin preparations, linear regression analysis showed that changes in IGFBP-1 correlated inversely with changes in IGF bioactivity (Figures 3 and 4). Three hours after the administration of study insulin, serum IGFBP-1 reached nadir, whereafter levels gradually increased to peak values at the end of the study (all p-values <0.05). Although the four different insulin preparations resulted in parallel changes in serum IGFBP-1, a detailed analysis revealed minor but significant differences when comparing the AUCs (for details please refer to Table 1). In general, insulin aspart preparations with higher proportions of the rapid-acting aspart induced lower IGFBP-1 AUCs during the first six hours and higher AUCs during the last three hours (Table 1).
Figure 4. Linear regression between the changes of IGF bioactivity and IGFBP-1 level. 0–3 hours (a) and 6–9 hours (b). The symbols represent patients with insulin aspart (black circles), BIAsp70 (open circles), BIAsp 50 (black triangles) and human insulin (open triangles). For all four insulin preparations a significant inverse correlation with IGFBP-1 was observed, being r = - 0.30 for insulin aspart, r = - 0.47 for BIAsp70, r = - 0.40 for BIAsp50, and r = - 0.52 for human insulin group during 0–3 hours (a), while r = - 0.83 for insulin aspart, r = - 0.57 for BIAsp70, r = - 0.40 for BIAsp50, and r = - 0.58 for human insulin group during 6–9 hours (b); all p-values <0.05. For clarity the reference line illustrates the trend of data in four insulin groups.
Serum IGFBP-2 increased in the early phase of the profile day whereafter levels declined towards baseline values. Neither peak levels nor AUCs differed when comparing the different insulin preparations (Table 1).
Serum IGFBP-3 remained unchanged during all four profile days. Although IGFBP-3 appeared to display differences during the last three hours, these differences were insignificant (Figure 2e and Table 1).
We have previously demonstrated that equal doses of human insulin, insulin aspart and the two biphasic aspart preparations BIAsp50 and BIAsp70 have distinct pharmacokinetic and -dynamic properties in patients with T1D [11] and this finding prompted us to investigate their effect on the circulating IGF system, which is known to respond to insulin. However, as scrutinized by the present study, the distinct pharmacokinetic properties of the tested insulin preparations only affected IGFBP-1 and these changes were minor and hardly of any major physiological significance. Supportive of this interpretation, levels of bioactive IGF responded similarly to the four insulin preparation and the same was true for total IGF-I, IGFBP-2 and IGFBP-3. On the other hand, our study clearly demonstrates bioactive IGF to be more sensitive to short-term changes in insulin exposure than total IGF-I. This observation highlights the important regulatory role of insulin (human as well as analogues) on the IGF system.
IGFBP-1 is the only component of the IGF system that is directly regulated by insulin, which inhibits the hepatic synthesis of IGFBP-1 at the transcriptional level [17-19]. As the liver is considered to be the main source of IGFBP-1, its serum levels can be used to estimate the hepatic exposure to insulin [17] as well as the hepatic sensitivity to insulin [20]. As expected, serum IGFBP-1 declined after sc administration of insulin, irrespective of type of insulin. However, some differences were indeed observed when comparing the four preparations. Overall, during the 9 hours of study human insulin resulted in the lowest IGFBP-1 concentrations. Furthermore, pure aspart differed from the two biphasic aspart preparations when comparing early and late effects, but overall the three aspart-containing preparations yielded similar AUCs. Whether these minor differences have any physiological importance remain uncertain. However, IGFBP-1 is an important regulator of free IGF-I [21] as well as bioactive IGF [22], at least when measured in vitro, and as we observed no differences in the response of bioactive IGF to the four insulin preparations, we speculate that the observed statistical differences in IGFBP-1 has little, if any biological significance. Thus, we conclude that despite clearly distinct pharmacokinetic and -dynamic profiles of the four insulin preparations, this did not translate into clearly distinct IGFBP-1 profiles. As we have no reasons to believe that the insulin sensitivity of the participants changed during the study period, this indicates that the four tested insulin preparations resulted in comparable hepatic insulin exposures and this we believe is valuable clinical information. Importantly, our observation is in agreement with a previous publication by Hedman et al., who compared 6 weeks of constant subcutaneous infusion of insulin lispro vs. human insulin [23]. These authors observed marked postprandial differences in blood glucose and plasma insulin, whereas the postprandial excursions of serum IGFBP-1 did not differ between the two insulin preparations. Thus, it seems fair to conclude that the glycemic response to rapid-acting insulin preparations cannot be used to predict the response of the IGF-system.
Circulating IGFBP-1 only constitute a minor fraction of the six IGFBPs [18] but it is, nevertheless, believed to act as an important short-term regulator of IGF actions in vivo[24]. Thus, it is generally believed that reductions in circulating IGFBP-1 result in a diminution of IGF binding capacity and consequently increases free and subsequently bioactive IGF [5,24]. With the cell based IGF-IR bioassay at hand we are able to determine the ability of serum to activate the IGF-IR in vitro[16]. Our findings demonstrated a strong interaction between IGF bioactivity and circulating IGFBP-1 levels. During the first three hours, a reduction in IGFBP-1 levels was accompanied by an increase in IGF bioactivity. Conversely, at the end of the profile day (6–9 h), the marked increases in IGFBP-1 associated with a large decline in IGF bioactivity. These findings illustrate the intimate relationship between insulin and the IGF system and suggests that in patients with T1D the actions of the IGF system may be more fluctuating and dependent on insulin administration than what is suggested from measurements of total IGF-I. However, we acknowledge that the clinical relevance of our finding needs to be clarified.
Unlike IGFBP-1 and bioactive IGF, total IGF-I and IGFBP-3 remained constant during the nine hours of study and no significant differences in total IGF-I outcomes could be detected among the four insulin preparations. This finding was, however, not surprising as the majority of circulating IGF-I is bound in ternary complexes composed of IGFBP-3 and the acid-labile subunit (ALS). These complexes are primarily dependent on GH rather than insulin and furthermore characterized by a circulating half-life of 12–15 hours [25,26].
Studies in humans and in experimental animal models have shown that IGFBP-2 is a key factor in the insulin-IGF cross-talk and also linked to insulin resistance [27-30]. Our study demonstrated for the first time that serum IGFBP-2 fluctuates after a meal-time insulin injection in patients with T1D, hereby supporting its metabolic relationship. As for IGFBP-1, the four insulin preparations resulted in virtually similar changes in IGFBP-2 levels, regardless of glycemic control. Whether the increase in IGFBP-2 serves to counteract the impact of IGFBP-1 on bioactive IGF remains unknown, but this is most likely, as IGFBP-2 has been demonstrated to correlate inversely with levels of bioactive IGF following a hyperinsulinemic clamp [28].
The present study has some limitations that should be taken into consideration for the interpretation of the results. Firstly, we compared peripheral levels of the different insulin preparations and they could differ from levels within the portal vein system. Secondly, we had a priori decided to withdraw patients when their plasma glucose exceeded 16 mM. This decision reduced the number of samples collected at six and nine hours and it may have contributed to underestimate any late occurring differences between the four insulin preparations. Thirdly, we have to acknowledge that the calculated dose of insulin was insufficient to maintain postprandial blood glucose levels within normal range. Thus, we cannot fully preclude that the use of higher insulin doses may have enhanced our ability to detect significant differences in the response of the IGF-system.
Molecular modification of human insulin, resulting in insulin analogues, aims to improve pharmacokinetic and -dynamic properties, but at the same time this may increase IGF-IR binding affinity, hereby raising clinical safety concerns. In this context, studies have demonstrated that insulin aspart resembles human insulin in its IGF-IR binding affinity and mitogenic potency [31]. In fact, the capacity of insulin aspart to cross-react with the IGF-IR in vitro was slightly lower than that of human insulin [16]. These findings were supported by the present clinical study demonstrating no increased IGF-IR activation in vitro following treatment with insulin aspart containing preparations. Furthermore, all three insulin aspart preparations had close to identical effects on the circulating IGF system as compared to human insulin, the only exception being slight differences in IGFBP-1, which however, were expected and in accordance with the pharmacokinetic properties of the tested insulins. Thus, in regards to short term effects on the circulating IGF system, our data yield no reason to concern when using insulin aspart containing preparations.
The present study demonstrated that despite distinct pharmacokinetic and -dynamic properties, insulin aspart preparations had similar effects on IGF-I concentration and IGF bioactivity as well as on levels of IGFBP-2 and IGFBP-3 as compared to those of human insulin. Differences were observed in regards to the very insulin sensitive protein IGFBP-1, but the magnitude of these differences were small and hardly on any major biological significance as they did not impact bioactive IGF. On the other hand, bioactive IGF appeared to be more sensitive to insulin exposure than total IGF-I, and hence our study suggests that the activity of the IGF system may be relatively dynamic in patients with T1D, being dependent on the prevailing insulin levels. However, the clinical and pathophysiological importance of such insulin-related fluctuations in IGF bioactivity remains to be clarified.
ANOVA: Analysis of variance; AUC: Area under the concentration-time curve; BIAsp: Biphasic insulin aspart; Cmax: Maximal concentration; Cmin: Minimal concentration; GH: Growth hormone; IGF: Insulin-like growth factor; IGFBP: Insulin-like growth factor binding protein; IGF-IR: IGF-I receptor; Tmax: Time to maximal concentration; Tmin: Time to minimal concentration.
Competing interest
The study was supported by an unrestricted grant from Novo Nordisk A/S. Zhulin Ma is the recipient of unrestricted grants for research from Novo Nordisk. Jens Sandahl Christiansen is the member of speaker's bureau and Advisory Boards and recipient of unrestricted research grants from Novo Nordisk. Torsten Lauritzen have received unrestricted grants for the ADDITION study (screening and intensive treatment of type 2 diabetes in primary care) from public foundations and the Medical Industry: Novo Nordisk AS, Novo Nordisk Scandinavia AB, ASTRA Denmark, Pfizer Denmark, GlaxoSmithKline Pharma Denmark, SERVIER Denmark A/S and HemoCue Denmark A/S. Torsten Lauritzen has held 3 lectures for the medical industry within the past 2 years. Torsten Lauritzen hold shares in Novo Nordisk. The other authors have nothing to disclose.
Authors' contributions
ZM carried out the clinical study, performed the statistical analysis and wrote the manuscript. JSC, TL and JF conceived of the study, participated in its design and coordination and helped to draft the manuscript. TL and TP helped to interpret results and revised the manuscript. CSW participated in the design of data management plan and performed the partial statistical analysis. All authors read and approved the final manuscript.
We would like to thank Kirsten Nyborg Rasmussen and Lone Kvist for skilled technical assistance.
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Ma Z, Parkner T, Frystyk J, Laursen T, Lauritzen T, Christiansen JS: A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50, and human insulin: a randomized, quadruple crossover study.
Diabetes Technol Ther 2012, 14:589-595. PubMed Abstract | Publisher Full Text
Bidlingmaier M, Friedrich N, Emeny RT, Spranger J, Wolthers OD, Roswall J, Koerner A, Obermayer-Pietsch B, Hubener C, Dahlgren J, Frystyk J, Pfeiffer AF, Doering A, Bielohuby M, Wallaschofski H, Arafat AM: Reference intervals for insulin-like growth factor-1 (IGF-1) from birth to senescence: results from a multicenter study using a New automated chemiluminescence IGF-1 immunoassay Conforming to recent international recommendations.
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Friedrich N, Wolthers OD, Arafat AM, Emeny RT, Spranger J, Roswall J, Kratzsch J, Grabe HJ, Hubener C, Pfeiffer AF, Doering A, Bielohuby M, Dahlgren J, Frystyk J, Wallaschofski H, Bidlingmaier M: Age and sex specific reference intervals across life-span for insulin-like growth factor binding protein 3 (IGFBP-3) and the IGF-I/IGFBP-3 ratio measured by new automated chemiluminescence assays.
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Reinhard M, Frystyk J, Jespersen B, Bjerre M, Christiansen JS, Flyvbjerg A, Ivarsen P: Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study.
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Pre-publication history
The pre-publication history for this paper can be accessed here:


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Category:1904 deaths
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People who died c. 1904.
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Mobutu Sese Seko is a blogger and freelance copywriter and, as such, he is made of money. He supplements his income with assets embezzled from the nation of Zaire from 1965-1997. He last stopped by to talk to us about Miss Destructo. You can read more of his political/pop-culture criticism and dick jokes at Et tu, Mr. Destructo?
Full disclosure here: I don't actually watch the Emmy awards or any award shows. In the past, I'd occasionally flip back and forth to them to see if anything interesting was going on, but now that YouTube and Gawker instantly compile the only legitimately entertaining parts of the shows, there's no point in bothering with the whole thing. (The only exception to this rule was the Jon Stewart-hosted Academy Awards, during which I was hoping he would make half of America very uncomfortable.) I don't have this attitude because I think I'm better than award shows. I watch a lot of garbage on television, often revoltingly dumb stuff like shows where they blow things up or the last four seasons of Law & Order: SVU.
Mostly I think I avoid awards galas because I just have an instant wincing reaction to anyone bursting into song, which accounts for about a third of all their original content. Aside from songs on really great comedy shows like 30 Rock, Futurama or The Simpsons, spontaneous musical theater makes my lips draw back in a rictus grin. I think this has something to do with knowing about WWII and the Holocaust as a small child and watching The Sound of Music. I kept shouting at the screen, "SHUT UP" and "THE NAZIS'LL FIND YOU IF YOU DON'T SHUT UP."
Giggle-girl Edie Falco (above, sorting) continued the Emmy streak of a Best Actress in a Comedy nod for a non-comic actress in a show that isn't funny.
Now, there's little point in complaining about old Emmy awards. We all know that Prometheus didn't steal the secret of Situation Comedy from Production Olympus and bring it to Larry Gelbart until 1972, and we all know that he was punished by Olympus until 1989, when he finally escaped and brought the final gift of Writers' Control to Matt Groening, James L. Brooks and Sam Simon. I could go into TV drama here, but that involves a long mythology about how the Lord of the Underworld (Steven Bochco) helped Davids Simon, Chase and Milch to be raised by wolves and found Homicide, The Wire, The Sopranos and Deadwood - all of which ultimately founded Rome, which was canceled after two seasons by morons.
As much fun as can be had mocking old winners and nominees, television has been revolutionized twice in the past 40 years. With comedy, it began with the layered irreverence and moral depth of M*A*S*H and was fully realized by The Simpsons. With drama, it began with Hill St. Blues and was fully realized by a murderer's row of solid shows on HBO. You can make a strong case for All in the Family kind of riding both these sea changes, but that interpretation depends upon your finding All in the Family the slightest bit entertaining, which I don't, and neither do any minorities or anybody under 40.
Anyway, the point here is that busting on the Emmys for the content of shows pre-dating these changes is sort of misguided, because it amounts to ridiculing a whole different conception of television, in terms of overall entertainment, pacing, intellectual challenge, meta-textual content, graphic subject matter and social flippancy. The problem with the Emmys is a problem of process, which can be pointed out with plenty of modern examples without going for the low-hanging fruit of wondering why the fuck anybody laughed at Phil Silvers, Hogan's Heroes or Love, American Style.
Modern Family economized on unfunny jokes and plot devices by making the unfunny screeching fat guy, the unfunny screeching gay guy, the unfunny screeching parent of a newborn and the guy with an 'I lick car batteries' haircut all the same person.
For instance, a quick look at any of the lists of winners linked from the Wikipedia page for the Primetime Emmys within the past generation or so is enough to annoy or generally confuse you. With the big-name awards, they tended to get the winners right, but the nominees are just Godawful. Take Outstanding Comedy Series; just look at it. They nominated Night Court? Really? I watched Night Court back when I was so young that I still had serious opinions about which was the superior pizza chain with a go-kart track and animatronic bears that played rock and roll with each other. Even back then, there were only three things about the show that were funny:
1. That its set looked so cheap that I kept expecting Dr. Who to show up on a charge of trying to show a young girl his TARDIS.
2. That the women who played the female bailiffs died, like, every season.
3. That its creator was named Reinhold Weege.
Hell, despite not being equipped at the time in any sexually functional way except those in which I might appeal to someone's uncle, I didn't watch for the comedy. It didn't seem to have any. I watched to see if Dan Fielding was ever going to doink Christine Sullivan. See? - that's how flawed the show was. I was still young and innocent, and even I didn't buy into the alleged chemistry between her and Judge Harry Stone. The sleazy prosecutor seemed like the hero, and I hadn't even been through middle or high school to generate any sufficient sociopathy yet.
I'm genuinely concerned about what this guy's going to do when he finds out I impersonated him on Twitter in a gritty series of updates about his confronting the darkness inside.
Finding the right hat can feel like walking through a minefield for guys. Did a murderer wear your hat? Was it ruined by bros? Are you just an idiot? Find out with our authoritative ranking of bad hats.
The Amazonians value combat prowess and purity of spirit. By wrestling half naked, they pay homage to both virtues by displaying their battle-forged bodies while preserving as much modesty as their society deems necessary. The gelatin in which they wrestle is symbolic of the fluid nature of battle, a concept the Amazonians call 'akgor-gra.'
Even the Armor of God won't save you from flying missionaries, terrible banditos, or Tom Arnold!
SA takes a look back at what our ancestors from the dawn of civilization clicked on THEIR computers!
My time as a captain in Sunless Sea, plus a review of Homeworld Remastered Collection
Featured articles and columns that don't fit anywhere else on Something Awful.
Copyright ©2015 Rich "Lowtax" Kyanka & Something Awful LLC.


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byJennifer Bosavage on
2007 Revenue: $22.134 billion
Lead Executive: Ron Rittenmeyer, president and CEO
EDS saw revenue increase 4.1 percent last year. It was impressive enough to entice HP to make a $13.9 billion play for the company earlier in May. HP's acquisition of EDS is expected to close in the second half of 2008. The deal will more than double HP's services revenue, which was $16.6 billion in fiscal 2007. [READ MORE]
As solution providers position themselves for growth, the pressure is on vendors and distributors to meet their partners' needs. Here CRN presents the 2015 Channel Chiefs, our annual look at the executives responsible for running channels at today's IT vendors.
Here are 10 recent searches by CRN visitors.
Cloud 100


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"At Mansfield University, we develop leaders. We accomplish this by focusing on the four core values that have been our tradition since 1912: Character, Scholarship, Culture, and Service."
Course Term and Dates: | Summer II (07/01/14 to 08/07/14) | |
Location: | Manfield Universty Campus 123 | |
Meeting Days and Times: | MON TUE WED THU 02:00PM to 03:40PM |
Instructor: | Ms. Martha A. Campbell | |
Prerequisites: | NONE | |
Corequisites: | NONE | |
Department: | Art | |
Course Description: | A multicultural approach is taken in this course that integrates western and non-western traditions. This is pursued by an overview of the general history of image and form in painting, sculpture, ceramics, architecture, jewelry, etc. Through a thematic design, the course looks at visual creations from several angles encompassing the social, cultural, ethnic, historical, political, and gender. |
Courses with insufficient enrollment may be subject to cancellation


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We first shot Taylor Momsen when she was fourteen years old, and co-starring in the independent Gus Van Sant flick Paranoid Park.Now Momsen is the front woman for a hard-rocking band, The Pretty Reckless, a model for Madonna's clothing line Material Girl, and the on-again-off-again debutante in Gossip Girl. (She's also seventeen years old, at least until the end of July, when the Leo becomes barely legal.)
We have outtakes from the newest NYLON Korea cover girl. See them by clicking here, or log onto your NYLON Smart Phone App, where you'll be able to screenshot all of them next week.


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Learn more about BTCC rookie Josh Cook with our driver profile:
BTCC team Power Maxed Racing is proud to announce the signing of Renault Clio Cup UK runner-up Josh Cook.
Josh will pilot the team's second Chevrolet Cruze for the 2015 season under the new #RacingforHeroes banner, the dedicated motorsport fundraising partner of the Help for Heroes charity.
Speedworks Motorsport is heading into the 2015 Dunlop MSA British Touring Car Championship confident about its chances of springing a surprise, after re-signing last year's leading rookie Tom Ingram for a second consecutive campaign behind the wheel of its heavily revised Toyota Avensis.
Speedworks enters its fifth season in the BTCC, determined to finally claim its long-awaited breakthrough podium finish, after edging consistently closer to the front of the field.
Former Dunlop MSA British Touring Car Champions Matt Neal, Jason Plato, Andrew Jordan, Robb Gravett and Tim Harvey have all signed up to take part in the Gerry Marshall Trophy race as part of this month's 73rd Goodwood Members Meeting.
Reigning constructor/manufacturer champions, Triple Eight Racing, have signed BRDC SuperStar Jack Goff to a one-year race deal to compete alongside 2013 BTCC Champion Andrew Jordan in the 2015 Dunlop MSA British Touring Car Championship (BTCC) in a second works-supported MG6.
The Briton, 23, made his series debut in 2013 after clinching the 2012 Clio Cup UK crown and has steadily progressed taking ten top-10 finishes throughout 2014, after the tail end of his debut season showed promise with a maiden BTCC podium in the final race of the year.
Power Maxed Racing has today confirmed the signing of 2014 Jack Sears Trophy winner Dave Newsham to drive in this year's Dunlop MSA British Touring Car Championship. Newsham will race in the teams' first year under new ownership and will be behind the wheel of the #17 Chevrolet Cruze Saloon for the 2015 season.
Two days of testing ahead of the start of the new Dunlop MSA British Touring Car Championship season have taken place at Thruxton in Hampshire, with many of the top teams taking the rare opportunity to test at the country's fastest circuit.
This year's Renault UK Clio Cup Champion will again be rewarded with an exclusive test with top British Touring Car Championship team Motorbase, courtesy of tyre supplier Dunlop.
2014 Champion Mike Bushell benefited hugely from a day spent behind the wheel of Motorbase's Ford Focus and was also able to work with Dunlop's technicians to learn about its BTCC race tyre, the Sport Maxx. He will now be on the grid when the new BTCC season starts at Brands Hatch in early April.


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Facebook and Twitter Black Friday Referrals Result in Less Than 1% of Online Sales
Description:Sales referred directly from Facebook and Twitter posts resulted in .68% and 0% respectively of online Black Friday sales this year. The numbers were down slightly from last year's numbers. (1:13)
Source: Mashable
Tags: Twitter Black Friday Referrals , black friday 2012 , black friday deals 2012 , black friday facebook referrals