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From the Publisher
"This has become my favorite of all Kay Kenyon's books. The science-driven men of Anglica have constructed a marvel of engineering—a bridge that crosses the ocean—but they don't understand the mystical forces they're facing in the dangerously seductive country of Bharata. As usual, Kenyon offers flawless world-building and a diverse cast of characters driven by conflicting and wholly believable desires. This is a rich, gorgeous, and marvelously detailed tapestry of a book."— Sharon Shinn, Author of Troubled Waters and Royal Airs
"Kay Kenyon has once again created a world into which one blissfully disappears, replete with magic and monsters, romance and reigning dynasties, set upon the fragile social scaffolding of mid-nineteenth century England. The story is, literally and figuratively, a bridge between the mystical and the very real, with a young heroine who a delivers a deliciously vicarious ride. Brilliantly told with elegant yet occasionally jarring prose, A Thousand Perfect Things is a masterwork from the mind of one of our best authors of compelling alternate realities."
— Larry Brooks, Author of Story Engineering


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CoreLogic® Releases January MarketPulse Report
IRVINE, Calif.,
Jan. 14, 2013 /PRNewswire/ -- CoreLogic (NYSE: CLGX), a leading provider of information, analytics and business services, today released its January MarketPulse report. The report indicates the CoreLogic Home Price Index (HPI
®), which is based on repeat sales, increased 7.5 percent in 2012, the largest increase since 2006. In 2013, CoreLogic projects home prices to rise 6 percent due to greater affordability fueling steady demand, a lower level of real estate owned (REO) sales and a low inventory of unsold homes.
(Logo: http://photos.prnewswire.com/prnh/20100609/CLLOGO)
Additional key findings in the January MarketPulse report include:
- Housing made an impressive recovery in 2012:
- Total homes sales increased 6 percent to 4.2 million, up from 3.9 million in 2011 – the first increase since 2005.
- Non-distressed homes sales increased 11 percent to 3.2 million.
- New sales increased 3 percent to nearly 300,000.
- Home price growth happened across many geographies.
- REO sales declined more than 20 percent to 600,000, the third annual consecutive decline.
- Short sales rose 23 percent to 370,000 units, the highest level since the real estate downturn began.
- Serious delinquencies declined by nearly 300,000 loans in 2012, which drove the seriously delinquent rate down to 6.9 percent, from 7.4 percent in 2011. Since the January 2010 peak, serious delinquencies have declined by 1 million loans.
- The housing market enters 2013 poised for further recovery:
- Rising home prices will continue to slowly release pent-up supply as under-equitied borrowers are unlocked and opportunistic sellers begin to provide relief to tight inventories.
- Geographic diversity in home price growth will continue.
- CoreLogic expects continued market improvement in serious delinquencies.
- Despite improvements and a positive outlook for the coming year, uncertainty remains on the impact of qualified mortgage and qualified residential mortgage requirements.
For a full copy of the January CoreLogic MarketPulse report, including a complete set of data and charts, visit http://www.corelogic.com/downloadable-docs/MarketPulse_2013-January.pdf.
About CoreLogicCoreLogic (NYSE: CLGX) is a leading property information, analytics and services provider in the United States and Australia. The company's combined data from public, contributory, and proprietary sources includes over 3.3 billion records spanning more than 40 years, providing detailed coverage of property, mortgages and other encumbrances, consumer credit, tenancy, location, hazard risk and related performance information. The markets CoreLogic serves include real estate and mortgage finance, insurance, capital markets, transportation and government. CoreLogic delivers value to clients through unique data, analytics, workflow technology, advisory and managed services. Clients rely on CoreLogic to help identify and manage growth opportunities, improve performance and mitigate risk. Headquartered in Irvine, Calif., CoreLogic operates in seven countries. For more information, please visit www.corelogic.com. CORELOGIC, the CoreLogic logo and HPI are trademarks of CoreLogic, Inc. and/or its subsidiaries. SOURCE CoreLogicCheck Out Our Best Services for Investors
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subset: commoncrawl


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Hello Everyone,
I have been a steady lurker for a long time now and I finally decided to join the head-fi community. I have an pair of Monster Turbines which have pretty much worn out and I am on the lookout for a new pair of IEMs as a replacement for my turbines and after a a lot of research(i.e reading up on past threads) I have zeroed in on RE0.
Just few days ago i bought 215s and didn't like their fit and cable AT ALL and decided promptly to return...
10/17/11 at 2:37pm


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Tunes for Turkey Revue 2013Event DetailsDate(s) & Time(s):: October 26, 2013 at 7:00 PM Location: Clayton Opera House Phone: 315-686-2200 Event Description
Sam Hopkins and his All Friends Band are back for the 2nd annual Tunes for Turkey Revue to benefit the local food pantry. The show will feature Kingston's best news blues band of 2013, The Roosevelts with Lisa Vee. Performing at 7:00 p.m. Saturday, October 26, at the Clayton Opera House, Sam and all the performers are donating their time and talent to raise awareness and funds for the local food pantry.
Return to event list.Tickets are $15 for all ages. Tickets may be purchased at the Clayton Opera House Box Office, by calling 315-686-2200 or visiting www.claytonoperahouse.com. The Clayton Opera House is located at 405 Riverside Drive in Clayton. Box office hours are 11 a.m. to 5 p.m. Tuesday through Friday and one hour before all performances. |
Thursday, February 26, 2015
, Watertown, NY
Click here for a free download of the latest Adobe Flash Player.
What's On TonightFull Schedule |


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The Glass House was beautifully decorated with Scandinavian simplicity and gorgeous pops of color, and everything was immaculate. The hostess, Tobi, and mom Jill were very helpful with dining and hiking suggestions. We especially enjoyed a beautiful hike to Mt. Edith Cavell, which was not on our tour-book list but recommended by Jill. And the breakfast home-baked treats are every... More
- Also Known As:
- The Glass House Bed And Breakfast
- The Glass House Hotel Jasper


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Sponsored by: Brakes Plus
Jan 28, 2014 4:00 PM by David Randall
Update: Highway 67 has been reopened.
DIVIDE - A driver is dead after colliding with a state snow plow truck in Teller County.
The crash happened just before noon on Tuesday on Colorado Highway 67 between Cripple and Divide, closing the road.
Capt. Charles Cargin of the Colorado State Patrol told The Gazette that the driver of a pickup truck lost control on a right turn and hit the blade of the snow plow.
A spokeswoman for the Colorado Department of Transportation, Amy Ford, says the plow was removing snow at the time of the crash. She says department supervisors will investigate along with the State Patrol.
2 months ago


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What does VSN mean in General?
This page is about the meanings of the acronym/abbreviation/shorthand VSN in the Computing field in general and in the General terminology in particular.
Find a translation for VSN in other languages:
Select another language:
Discuss this VSN abbreviation with the community:
Use the citation below to add this abbreviation to your bibliography:
"VSN." Abbreviations.com. STANDS4 LLC, 2015. Web. 1 Mar. 2015. <http://www.abbreviations.com/term/47329>.
VSN also stands for:
- Vehicle Serial Number
- Veterinary Specialist Network
- Virtual Seismic Network
- Vita Scooby Nut
- Vital Signs Normal
... and 3 more »
Nearby & related abbreviations:
Alternative search:
- Search Volume Serial Number on Amazon
- Search Volume Serial Number on Google


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Best Feature Ideas: SFJ's Show and Share
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Visual Storytelling with Haiku Deck: A Digital Tools Tutorial
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The 9-to-5 Cure
Work on your Own Terms and Reinvent your Life
From Library Staff
"...groundbreaking new guide outlining an immediate and practical strategy for being abundantly employed in any economy. Learn how to insulate yourself from sudden and total job loss by following the practical advice detailed in each chapter. Earn a good living in any economic environment by... Read More »


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56,796Photo Credit: lonepine
Film actor, producer, playback singer
Prithviraj Sukumaran (born 16 October 1982), credited mononymously as Prithviraj , is an Indian actor, playback singer and producer best known for his work in Malayalam films. He has also acted in a number of Tamil, Telugu and Hindi films. Wikipedia
Age: 32
Born: 16th October, 1982, Trivandrum, India
Height: 6' 0" (183 cm)
Nationality: Indian
Kaaviya Thalaivan (2014)
The lives of two theatre artists and the competition between them in a small drama troupe.
Prithviraj Sukumaran Fans Also Viewed
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Points: 2 Posts: 2 -
Points: 2 Posts: 2


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What does AIPN mean in Australian?
This page is about the meanings of the acronym/abbreviation/shorthand AIPN in the Regional field in general and in the Australian terminology in particular.
Find a translation for AIPN in other languages:
Select another language:
Discuss this AIPN abbreviation with the community:
Use the citation below to add this abbreviation to your bibliography:
"AIPN." Abbreviations.com. STANDS4 LLC, 2015. Web. 27 Feb. 2015. <http://www.abbreviations.com/term/331638>.
AIPN also stands for:
- Adult Injury Prevention Network
- American International Petroleum Corporation
- Arizona Independent Policy Network
- Association Of International Petroleum Negotiators
... see them all »
Nearby & related abbreviations:
Alternative search:
- Search Australian Injury Prevention Network on Amazon
- Search Australian Injury Prevention Network on Google


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Porsche 944 coupe 2.5 ltr 1986 in good condition 1986 Porsche 944 coupe 2.5 ltr in good condition. Nice and excellent running car for a... More
1989 Porsche 911 original Holland Porsche delivered policecar Originally built for the Holland police, this Porsche 911 3.2 Targa from 1989. The Holland police had... More
This 1985 Porsche Carrera Coupe is finished in White Gold Metallic over Cadbury Brown leather and has less than 83k miles. Sold new on March... More
Porsche 911SC Targa 1980 drives good Good running and driving Porsche 911 SC Targa with matching numbers good running engine. Nice car to drive as... More
EzCars101 in historic Encinitas, CA is pleased to present a RARE 1988~ Porsche 944 Special Edition Silver Anniversary!!! COLOR In beautiful Zermatt Silver Metallic... More
This 1982 Porsche 911 SC is in Guardsman Red with Beige. The Porsche 911 SC Coupe - a car that will never go out of... More
NICE LAST YEAR OF THE PORSCHE 944 IN THE RARE ICE METALLIC BLUE WITH DARK BLUE LEATHER INTERIOR. RUNS AND LOOKS REAL NICE BUT DOES... More
Porsches 911 Turbo commonly known by its internal code 930 is one of the most legendary sports cars of all time. The 930 propelled... More


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Google Chrome
A newer version of Google Chrome is available.
Or, Learn More About Google ChromeSpectacular
Full user review
"Above issues ??"
Great Browser
I see above issues Malware etc, and wonder where they downloaded 30.0 from? I had issues also after installing from cnet? Went directly to Chromes site and no issues
After having considerable issues with downloads from cnet I now check for new downloads on cnet but go directly to their site to install ?


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You know they came with a top
from Jeezy (Ft. Freddie Gibbs) – Rough Lyrics on Genius
Pyrex pots are a type of pots that are known to come with tops.
They are also known to be used for cooking crack, which is why he could be using them as a reference to his drug-dealing days.
To help improve the quality of the lyrics, visit Jeezy (Ft. Freddie Gibbs) – Rough Lyrics and leave a suggestion at the bottom of the page


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Gestalt Therapists in Madison
Verified by Psychology Today
Andrea Schultz
Clinical Social Work/Therapist, LCSW, RYT, CPT
"With compassion and a gentle, yet direct style, I can help you to navigate painful experiences and emotions, to shift patterns of self-criticism, judgment and shame and to cultivate self-acceptance and desired changes in yourself and in your relationships... I work with clients experiencing anxiety, depression, trauma, grief, illness, self-abuse, relationship issues, compulsions, impulsivity, eating disorders, and identity struggles as well as other lifelong and situational challenges. I firmly believe in our capacity to heal, to find comfort and joy in our lives and to know greater peace. I offer individual, couples, group and skype sessions.
Verified by Psychology Today
Patti Bee
Counselor, MS, LPC, NCC
"People tend to find me because they have tried much therapy work and are still dealing with old issues like emotional trauma & compelled behaviors that won't budge. I use Brainspotting and Internal Family Systems (IFS). IFS gives incredible access to the hidden causes that a person has not accessed before in therapy. Brainspotting, is a neurological method, gazing on a spot, and accesses the deep brain. Both Brainspotting & IFS Inner Parts Work can rewire the brain. There's much case-based evidence supporting their effectiveness in treating anxiety, depression, traumatic stress, & other mental health issues. I offer a free, 30 mins. Phone Consult.
Verified by Psychology Today
Ann Veilleux
Clinical Social Work/Therapist, MSSW, LCSW
"Are you unhappy in your relationship? Do you feel that the two of you are stuck and not making things better? Yours is a common problem. Maintaining a personal relationship can be the hardest job there is - for a lot of us. I teach couples how their mode of communicating is getting in the way of feeling trusting and close. I am particularly skilled in catching the subtleties of how people effect each other with out realizing it. Let's work together to regain what it was that brought you together in the first place.
Verified by Psychology Today
Amy Collins Therapy
Marriage & Family Therapist
"Do you long for more fulfillment in your relationships? Are you struggling with the life transition of a new baby or a loss? Do you want to change your gender and need support navigating those changes? I offer individual and relationship therapy on a wide array of topics. You are the expert in your life, and my goal is to create an accepting, non-judgmental environment, which offers you the opportunity to explore patterns and behaviors that no longer benefit you. My passion is helping people recognize that they are their own greatest resource.
Verified by Psychology Today
Susan Hofer
Counselor, MS, LPC
"Difficulties are a part of being human. Yet, somehow, we often feel alone in the face of those difficulties. Whether struggling with individual troubles, relationship concerns or matters related to children or family, it can be hardest to talk to others when we need guidance the most. But no matter how daunting your situation, there are always possibilities. Therapy is a collaborative relationship that provides a safe place to discover new perspectives and tools to move you in the direction you want to go. It can help you discover the signs within already pointing you in the right direction.
Verified by Psychology Today
Heather Seeley-Schreck
Marriage & Family Therapist Intern, MA, LMFT-T
"I hold an MA in Counseling Psychology with a concentration in Somatic Psychology. I have experience with adolescents and adults in many capacities.These range from individual/couples counseling, crisis work, group facilitation, and outreach. My areas of specialization are queer identities, gender, sexuality, trauma, anxiety/depression,and communication.I work with many different modalities including CBT and DBT.These all include work through a somatic lens.I love helping people navigate their internal landscapes,and I am excited to build therapeutic relationships in my practice.
Verified by Psychology Today
Dawn Donner-Chambers
Counselor, MA, LPC
"My name is Dawn Donner-Chambers and I am a Licensed Professional Counselor. I have provided counseling to children and adolescents for over 20 years. I often use creative arts therapies in my work. These modalities utilize self expression and include art, play, music, writing, bibliotherapy and games in the context of therapy. My therapy offers a gentle and developmentally appropriate approach to helping young people of all ages heal.
Verified by Psychology Today
Rita Hockers
Clinical Social Work/Therapist, LCSW
"I am a licensed psychotherapist who has been counseling individuals and couples for over 25 years. I work with compassion, non-judgement and respect. I utilize a variety of different modalities, including traditional talk therapy, cognitive/behavioral therapy, mindfulness meditation, art therapy, gestalt therapy and energy work. I use different approaches with different people, depending on their needs. My ideal clients are those who have anxiety, OCD or depression. I also enjoy working with couples who want to improve their communication skills and resolve conflicts easier.
Verified by Psychology Today
April Shields
Counselor, LPC, NCC, DCC
"Do you feel like your life is passing you by? Are you stuck in a career that doesn't inspire you or relationships that don't nurture you? Are you ready to consider changes that will bring joy to your life? I can help you develop more positive relationships and become more aware of what might be stopping you from moving forward in your personal and professional life. I provide a safe empathic environment that opens the way for self-discovery. You will feel supported and more confident as you take steps toward living the life you were meant for.
Verified by Psychology Today
Linda C. Pettersen
Clinical Social Work/Therapist, LCSW
"I love to strengthen marriages using marital therapy and have had good success with reaching a couple's goals over my 35yr career.Most couples wait too long to come in for a "tune-up" when early intervention and problem solving is ideal. Otherwise, we get into major repairs in the couple relationship which is challenging for all. I have alot of experience working with blended families and I have led divorce adjustment grps for 26 years here in Madison. I am therefore especially suited for persons needing to complete grief work and rebuild their lives after major losses.
Verified by Psychology Today
Darlene M Meiners
Counselor, MA, LPC
"I have 28 years of experience working with children, adolescents, teens, & families in various settings. As a mental health professional, it is my goal to provide a broad range of high quality, innovative, creative, and affordable services to support the mental health needs of my clients. I provide mental health services to clients, ages 2 through 17, with support and coping skills to achieve successful and positive mental health growth throughout the developmental years. I utilize creative age appropriate methods of therapy to assist children, adolescents and teens in the therapeutic process.
Verified by Psychology Today
Wendy Alettha
Clinical Social Work/Therapist, LCSW
"Separation from and mistrust of our inner nature and of Nature all around leads to pervasive fear and a deep sense of loss (anxiety, depression, addiction,grief and shame) that we often don't understand and struggle to change. Healing from the effects of this Self alienation can feel very dangerous as you open up the dark, hidden places in your mind and heart. You do not have to do this alone.
My commitment as your therapist is to be present and compassionate; supporting your curiosity and connection with the living energy of what you love and who you really are.
Verified by Psychology Today
Full Potential Coaching & Counseling, LLC
Drug & Alcohol Counselor
"Ted Izydor has been providing mental health and addictions counseling to adolescents, adults, couples and families for over 20 years. He blends a supportive and reality based approach with best practiced approaches to help clients get the results they are looking for. Ted was a key developer of the Alternatives to Aggression teen program at Family Service in Madison, Wisconsin. He has appeared on several television and radio shows to present expert opinion on addiction and violence issues. Ted is an accomplished triathlete and social entrepeneur and also does personal coaching for adolescents, adults and professionals.
Verified by Psychology Today
Brian L Berninger
Counselor, MA, LPC
"I offer counseling for couples, adults, adolescents, families, and treat a full range of life issues. I have several years experience diagnosing and treating mental health conditions from public and private practice settings, and draw on several therapeutic methods to assist clients with a consistently warm, non-judgmental approach. In addition to individual therapy, I am experienced with couples. I also work with families, resolving difficult parent-teen and sibling relationships.
Verified by Psychology Today
Kathryn Ripp
Clinical Social Work/Therapist, LCSW, CSAC
"I love being a therapist and having the privilege of helping people heal, grow, and discover (or re-discover) their purpose in life. It takes tremendous courage to share with another person what you want to change about yourself. I feel that my role is to be a compassionate guide and facilitator to help you learn about yourself, your roots, your helpful and unhelpful personal habits and patterns with others. I use art, music, psychodrama, dreamwork, intuition and active listening to help you challenge yourself and become the sort of person you want to be in the world.
Verified by Psychology Today
Jeffrey Czebotar
Counselor, MS, LPC, SAC
"Confused and overwhelmed. Feeling intense emotions. Having relationship difficulties or struggling with alcohol/drug abuse or addictions? Move toward deeper understanding and personal growth using approaches that include guidelines for working with individuals/couples/families. Working with systems thinking, multiplicity of the mind, and pysical-emotional process, identify and work with the sub-personalities and "parts" of your internal system to understand the origin and make-up of your own character structure, and achieve true happiness, balance and harmony.
Verified by Psychology Today
Mary Ellen Miller
Clinical Social Work/Therapist, LPC
"My philosophy for therapy is that within everyone is the inherent will to be the best person one can be. Therapy acts as guideposts to assist individuals with developing and rebuilding their internal coping strategies, problem solving skills, and the desire to live life to the fullest.
Verified by Psychology Today
Victoria Ellington-Deitz
Counselor, MA, LPC, RSMT
"I work with older children, teens, and adults. I haved helped clients experiencing anxiety, stress, trauma, depression, uncontrollable anger, eating disorders, self-harming behaviors, suicidal thoughts, and problems regulating behavior and emotion. Other clients come for therapy to ease life transitions, self-exploration and self-empowerment. My style is collaborative, involving strength-based, cognitive, behavioral, and body-centered techniques in both individual and group therapy. Specializing in movement, mindfulness and relaxation, I have worked in a variety of agencies, hospitals, and private practice settings. In addition to being a professional counselor, I am also a registered somatic movement therapist.
Verified by Psychology Today
Jordonna M Hall
Counselor, LPC, NCC
"I am a licensed clinical professional counselor specializing in individual, couple, and family therapy, and I maintain a private practice in Madison. I have over 10 years of experience as a therapist and assessment clinician, and am currently serving as private practitioner working with a broad spectrum of clients. My areas of expertise include adolescent psychology, adult and geriatric therapy, marriage and couples therapy, LGBT counseling, psychological assessment, anxiety, and depression, as well as animal-assisted therapy with the help of my co-therapist, Archie.
Verified by Psychology Today
Kaitlyn Ann Laurie
Counselor, MS, LPC
"I have a varied practice. I see adults, children, couples and families. My focus is on people being able to move forward in their lives. It is a mending of the past beliefs and teachings all people develop as we grow up. The mending lets us see the present as it really is and make the best decisions for our lives. I find great joy in watching people grow and find their path in life. When couples come together to explore their relationship, often that is some of the finest therapy that can happen. It is an honor to assit them.
Gestalt Therapists Gestalt therapy seeks to integrate the client's behaviors, feelings, and thinking, so that their intentions and actions may be aligned for optimal mental health. The therapist will help the client become more self aware, to live more in the present, and to assume more responsibility for taking care of themself. Techniques of gestalt therapy include confrontation, dream analysis, and role playing. If you're looking for Gestalt therapy in Madison or for a Madison Gestalt therapist these professionals provide gestalt therapy, gestalt psychology, gestalt psychotherapy, gestalt counseling and gestalt group therapy. They include Gestalt therapists, Gestalt psychologists, Gestalt psychotherapists and Gestalt counselors.
How can I tell if a therapist is right for me? Therapists in Madison have broad skills and are able to work with a wide range of issues. For example, if you're seeking a marriage counselor in Madison you'll find that most therapists are trained in marriage counseling or couples counseling in Madison and couples therapy. And they welcome families for family counseling in Madison or family therapy in Madison. |


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Administrative leave for BHB chief of staff
The Bermuda Hospitals Board last night confirmed its chief of staff Dr Donald Thomas has been put on administrative leave.
In a short statement, a BHB spokesperson said: "We can confirm that our chief of staff, Dr Donald Thomas, is currently on administrative leave while a Board review is carried out. We cannot comment any further on individual matters, but interim arrangements are being made to ensure continuity of medical leadership."
Dr Thomas, an American doctor, was appointed chief of staff in 2007, and has more than three decades experience as a healthcare practitioner.
- Which of the following best describes your opinion on how Senior Civil Servant job positions should be granted?
- Senior civil servants should be appointed on a temporary contract renewable basis.
- 74%
- Senior civil servants should continue to be appointed on a permanent basis
- 18%
- Don't Know
- 8%
- Total Votes: 2155
- Poll Archive


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Synopsis: Noted physician and veteran TV host Dr. Drew Pinsky, who is widely known as just Dr. Drew, enters the daytime-TV game in this half-hour show in which he helps guests dealing with issues ranging from various addictions (including shopping and hoarding) to health issues. Pinsky and a panel of experts in each episode help solve the guest's problem and, as the title suggests, put the person on the path to a "life change." Some guests undergo dramatic physical changes while others have less obvious, emotional breakthroughs. Dr. Drew and the expert panel also provide viewers with information that can help them in their daily lives.
Show More »« Less
Language: English Release Date: 19 September 2011 Genres: Talk, Health Time Period: 2010s
Rate it
No upcoming episodes on TV. Watch them Online.
Honey Boo Boo Child shares her Go Go Juice with Dr. Drew
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Kid letter dares Jimmy Fallon to dance on his desk, so he busts out amazing middle-aged dad dance moves
Chris Hemsworth and Kate McKinnon's 'Dirty Dancing' lift goes horribly wrong in these 'SNL' promos
'Agents of SHIELD' Season 2: Bobbi and Mack want Nick Fury's toolbox - but are they HYDRA?
'Battle of the Exes 2': Bananas' return puts Leroy and Nia in a dangerous position
'Born in the Wild' premiere: Will you tune in again?
Watch Justin Bieber get groped by Jeffrey Ross in Comedy Central Roast promo
Zap2it First: See Patricia Arquette team up with James Van Der Beek on 'CSI: Cyber'
Zap2it First: 'New Girl's' Jess puts a new spin on the one night stand with Josh Gad
Kendall and Kylie Jenner join Kim Kardashian video game, steal the show
First look at Anthony Hopkins and Ian McKellen in Starz and BBC's 'The Dresser'
Should 'SNL' have kept this 'Fifty Shades of Grey' sketch over 'ISIS'?
Allegiance: Closing In On The Truth
2015 renewed TV shows: 'Man Seeking Woman' renewed for Season 2
'Born in the Wild' documents outdoor childbirth, medevac standing by
No data found.


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Top-Precision Optical Atomic Clock Starts Ticking
Feb. 26, 2015 A state-of-the-art optical atomic clock is now 'ticking away.' As the first of its kind in Poland and one of just a handful of clocks of this caliber in the world, the new clock will keep ... full story -
Can Coffee Reduce Your Risk of MS?
Feb. 26, 2015 Drinking coffee may be associated with a lower risk of developing multiple sclerosis (MS), according to a new ... full story -
Caging of Molecules Allows Investigation of Equilibrium Thermodynamics
Feb. 26, 2015 High performance materials for gas storage, thermal insulators or nanomachines need a thorough understanding of the behavior of the material down to the molecular level. Thermodynamics, which have ... full story -
Interaction of Atlantic and Pacific Oscillations Caused 'False Pause' in Warming
Feb. 26, 2015 The recent slowdown in climate warming is due, at least in part, to natural oscillations in the climate, according to a team of climate scientists, who add that these oscillations represent ... full story -
Type 2 Diabetes, Fatty Liver Disease Reversed in Rats
Feb. 26, 2015 A controlled-release oral therapy has been developed by scientists that reversed type 2 diabetes and fatty liver disease in rats, according to a study. "Given these promising results in animal ... full story -
Asian Herb Holds Promise as Treatment for Ebola Virus Disease
Feb. 26, 2015 New research focuses on the mechanism by which Ebola virus infects a cell and the discovery of a promising drug therapy candidate. A small molecule called Tetrandrine derived from an Asian herb has ... full story -
How Mantis Shrimp Evolved Many Shapes With Same Powerful Punch
Feb. 26, 2015 The miniweight boxing title of the animal world belongs to the mantis shrimp, a cigar-sized crustacean whose front claws can deliver an explosive 60-mile-per-hour blow akin to a bullet leaving the ... full story -
Method for Mapping Neuron Clusters Developed
Feb. 26, 2015 A method for identifying clusters of neurons that work in concert to guide the behavior has been developed by researchers. Their findings address a long-standing mystery about the organization of the ... full story -
GLP-1 Secretion Is Reduced in Overweight, Pre-Diabetes and Type 2 Diabetes
Feb. 26, 2015 The world's largest study looking at the secretion of the gut hormone GLP-1 has found that the secretion is reduced among overweight and obese people, people with pre-diabetes and newly ... full story -
Neurons That Help Predict What Another Individual Will Do Identified
Feb. 26, 2015 Investigators have discovered two groups of neurons that play key roles in social interactions between primates -- one that is activated when deciding whether to cooperate with another individual and ... full story -
Bumblebees Make False Memories Too
Feb. 26, 2015 It's well known that our human memory can fail us. People can be forgetful, and they can sometimes also 'remember' things incorrectly, with devastating consequences in the classroom, ... full story -
Building Blocks of the Future Defy Logic: New Logic-Defying Mathematical Model
Feb. 26, 2015 Wake up in the morning and stretch; your midsection narrows. Pull on a rubber band and it becomes thinner. One might assume that materials will always stretch and thin. Wrong. Thanks to their ... full story -
Amphibian Chytrid Fungus Reaches Madagascar
Feb. 26, 2015 The chytrid fungus, which is fatal to amphibians, has been detected in Madagascar for the first time. This means that the chytridiomycosis pandemic has now reached a biodiversity hotspot. Researchers ... full story -
Moffitt Researchers Identify Protein Pathway Involved in Brain Tumor Stem Cell Growth
Feb. 26, 2015 Glioblastomas are a highly aggressive type of brain tumor, with few effective treatment options. Researchers are one step closer to understanding glioblastoma development following the identification ... full story -
New Research Predicts When, How Materials Will Act
Feb. 26, 2015 A material might melt or snap in half. And for engineers, knowing when and why that might happen is crucial information. Now, a researcher has laid out an overarching theory that explains why certain ... full story -
Could Squirmy Livestock Dent Africa's Protein Deficit?
Feb. 26, 2015 Two graduate students are working to introduce highly productive kits for farming mealworms to regions such as sub-Saharan Africa where eating insects is already culturally palatable. They are just ... full story -
New X-Ray Microscope for Nanoscale Imaging
Feb. 26, 2015 A new microscope at the Hard X-ray Nanoprobe will ultimately deliver nanoscale resolution imaging for everything from proteins to fuel cell ... full story -
Superatomic Nickel Core and Unusual Molecular Reactivity
Feb. 26, 2015 Scientists have revealed a unique molecular fragment Ni2O2, consisting of two nickel atoms and two oxygen atoms, that have shown plausible superatomic properties. Supeatoms are important structural ... full story -
Teacher Prejudices Put Girls Off Math, Science, Study Suggests
Feb. 26, 2015 Although higher education has already opened the door to equal opportunities for women and minorities in the US in the math and science professions, a new study suggests that elementary school ... full story -
Chemo Before Breast Cancer Operation Increases Likelihood of Breast-Preserving Procedure
Feb. 26, 2015 Patients with larger malignant tumors of the breast who undergo chemotherapy before a breast cancer operation are more likely to opt for a breast-preserving procedure and forgo a mastectomy (surgical ... full story
- Top-precision optical atomic clock starts ticking
- Can coffee reduce your risk of MS?
- Caging of molecules allows investigation of equilibrium thermodynamics
- Interaction of Atlantic and Pacific oscillations caused 'false pause' in warming
- Type 2 diabetes, fatty liver disease reversed in rats
- Asian Herb Holds Promise as Treatment for Ebola Virus Disease
- How mantis shrimp evolved many shapes with same powerful punch
- Method for mapping neuron clusters developed
- GLP-1 secretion is reduced in overweight, pre-diabetes and type 2 diabetes
- Neurons that help predict what another individual will do identified
- Bumblebees make false memories too
- Building blocks of the future defy logic: New logic-defying mathematical model
- Amphibian chytrid fungus reaches Madagascar
- Moffitt researchers identify protein pathway involved in brain tumor stem cell growth
- New research predicts when, how materials will act
- Could squirmy livestock dent africa's protein deficit?
- New x-ray microscope for nanoscale imaging
- Superatomic Nickel core and unusual molecular reactivity
- Teacher prejudices put girls off math, science, study suggests
- Chemo before breast cancer operation increases likelihood of breast-preserving procedure
- New insight found in black hole collisions
- Thinking of God makes people bigger risk-takers, study suggests
- The eyes have it: Cats put sight over smell in finding food
- Persistent Insomnia, Increased Mortality Risk: Link found by researchers
- Twin study lends new insights into link between back pain and depression
- Emergency doctors and paramedics commonly misinterpret documents for end-of-life care choices, study finds
- Optogenetic stimulation of the brain to control pain demonstrated in study
- Pancreatic cancer patients who benefit from personalized treatment identified
- Marshaling the body's own weapons against psoriasis
- Criminologist's study shows lack of mental health care for prisoners
- 'Blue-green algae' proliferating in lakes
- Optical features embedded in marine shells may help develop responsive, transparent displays
- Aggressive plant fungus threatens wheat production
- MUSE goes beyond Hubble: Looking deeply into the universe in 3-D
- Research cracks code governing infections single-stranded RNA viruses
- One brain area, two planning strategies
- Early signs in young children predict type 1 diabetes
- Forest tree seeds stored in the Svalbard seed vault
- New evidence helps health workers in the fight against Ebola
- Lake Tahoe research provides new insights on global change
- Pockets of calm protect molecules around a supermassive black hole
- Sticky protein hails new approach for treating Parkinson's
- Sewage provides insight into human microbiome
- Study maps extroversion types in the brain's anatomy
- One in 3 women could potentially be spared chronic pain after breast cancer surgery
- Million person study examines long-term effects of blocking inflammation
- Sharp rise in experimental animal research in US
- Bariatric surgery affects risk of pregnancy complications
- People with ADHD are twice as likely to die prematurely, often due to accidents
- Sleeping over 8 hours a day associated with greater risk of stroke
- Felling of tropical trees has soared, satellite shows, not slowed as UN study found
- Hidden gene gives hope for improving brain function
- How the 'mute' cicada sings
- Antifreeze protein from ticks fights frostbite in mice
- The body's Transformers: Some proteins alter configuation
- Plant chemicals may prevent liver damage caused by fat accumulated during menopause
- Molecular feedback loop gives clues to how flowers drop their petals
- Vaccine hesitancy: Journal collection investigates vaccination decision-making
- Simple way to make and reconfigure complex emulsions
- Monster black hole discovered at cosmic dawn
- How the landscape of the pancreatic cancer genome is coming into view
- Epigenetic 'switch' regulates RNA-protein interactions
- Consideration of costs can reduce moral objections to human organ sales and other 'repugnant' transactions, says researcher
- Link between inflammation, tissue regeneration and wound repair response
- Unusual disease that causes acute confusion may be underdiagnosed
- Clusters of aluminum metal atoms become superconductive at surprisingly high temperatures
- Physicists offer a solution to the puzzle of the origin of matter in the universe
- Quick antibiotics reduce PICU needs and mortality of pediatric cancer patients
- Bending a highly energetic electron beam with crystal
- Widely used food additives promotes colitis, obesity and metabolic syndrome, shows study of emulsifiers
- First direct observation of carbon dioxide's increasing greenhouse effect at Earth's surface
- New flow battery to keep big cities lit, green and safe
- New technology could make treatment of oil and gas wastewater simpler, cheaper
- The £180 billion bill for living in a material world: Material lifestyles not making us happier
- Parkinson's disease patients have reduced visual contrast acuity
- Possible biological trigger for canine bone cancer found
- Breakfast habits affect teens' metabolic responses to protein-packed morning meals
- Cellular communication offers easy fog detection for roads and runways
- Biology teachers: Understanding faith, teaching evolution not mutually exclusive
- Learning by eye: Silicon micro-funnels increase the efficiency of solar cells
- Could an HIV drug beat strep throat, flesh-eating bacteria?
- Molecular mouse-trap technique sheds light on key cell processes
- Oat breakfast cereals may contain a common mold-related toxin
- Magnetic nanoparticles enhance performance of solar cells
- Postoperative mortality rates low among patients with HIV prescribed ART
- Cherenkov Effect improves radiation therapy for patients with cancer
- Study linking suicidal behavior, psychotic experiences may yield strategies to help prevent suicide attempts
- What does the future hold for treating patients with locally advanced breast cancer?
- More than two hours of TV a day increases high blood pressure risk in children by 30%
- Destroying tumor material that 'cloaks' cancer cells could benefit patients
- Women twice as likely to see pot as risky
- Climate-warmed leaves change lake ecosystems
- Is your busy schedule affecting your health? Time might not be the problem
- In quest for better lithium-air batteries, chemists boost carbon's stability
- Researchers enable solar cells to use more sunlight
- Uncertainties must be taken into account in fisheries stock assessment
- Being better problem solvers helps mountain chickadees survive at higher altitudes
- Omega-3 fatty acids, vitamin D may control brain serotonin, affecting behavior and psychiatric disorders
- Warning on use of drug for children's sleep
- Meditation can reduce chronic neck pain, study shows
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Due diligence
TRUenergy to test its power
PUBLISHED: 04 Jun 2012 00:01:45 | UPDATED: 05 Jun 2012 00:45:16PUBLISHED: 04 Jun 2012 PRINT EDITION: 04 Jun 2012Global equity markets have been so treacherous that floats are enduring their slowest start to a year since 2009. TRUenergy will brave the markets in the hope there is plenty of capital waiting for a safe haven.
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Topics | Mergers & Acquisitions /IPO's , Financial Markets /Equities Markets , Energy & Utilities /Electricity |


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The Business Law section's next meeting will be on Tuesday, October 15, 2013, at 12 noon at Stoel Rives, 510 L Street, Suite 500. (NOTE that this is a new meeting location for this section.)
Uniform Commercial Code - Rick Goldfarb, a partner in Stoel Rives Seattle office, a 25-year member of the Alaska bar and a frequent speaker on UCC matters, will present a refresher on the basics of UCC Article 9, the amendments that became effective on July 1, 2014, and as some traps to avoid in advising debtors or creditors. There will also be time for UCC Q&A. Pizza will be provided by Stoel Rives. 1 General CLE Credit.
For more section information, please contact co-Chairs Matthew Block, firstname.lastname@example.com or 907-952-5034; and John Kauffman, firstname.lastname@example.com or 907-277-1900.


text:
How Do You Transmit Hpv
Here's a taste of what TheBody.com has to offer on this topic:
Ask the Experts
Transmitting HPV to menThree years ago I was diagnosed with dysplasia - precancerous cells on my cervix due to HPV. I was treated (cryotherapy) and my following colposcopy showed that there were no cancerous cells left. Is there any way that my HPV could cause my...Response from Bruce Dezube, M.D.
Harvard Medical School
...It sounds like that BOTH you and your boyfriend have or have had an HPV infection (human papillomavirus, "the wart virus").It would be most unlikely that your HPV could cause your boyfriend's warts to worsen. Given that you both
Read more »
My warts are all cleaned up; can I still transmit HPV?In '99 I was diagnosed with high risk HPV and genital warts. The wart was treated with aldara, and... Read more »Can a man transmit HPV disease to his spouse? Can he have childrenThanks for your answer to my previous question. It is good news that people, who have anogenital... Read more »
The Human Papillomavirus (HPV): Lost in Space...& Co., Inc., and Cervarix™, from GlaxoSmithKline, were recently approved to fight certain sexually transmitted strains of human papillomavirus (HPV), which is associated with genital warts and the development of cervical cancer. In March 2007,... Read more »Human Papillomavirus (HPV)...How Are HPV Infections Treated? The Bottom Line NOTE: In the U.S., counseling and referrals are available on a national human papillomavirus (HPV) hotline. Call toll-free at 877-HPV-5868 (877-478-5868). What Is HPV? There are over 100... Read more »HPV (Human Papillomavirus)... What is HPV? HPV (human papillomavirus) is a sexually transmitted virus. It is passed on through genital contact (such as vaginal and anal sex). It is also passed on Read more »Human Papillomavirus (HPV) Infection in Heterosexual South African Men Attending Sexual Health Services: Associations Between HPV and HIV Serostatus... The study authors assessed distribution of human papillomavirus genotypes and determined the associations between HPV and HIV co-infection in sexually active heterosexual men with anogenital Read more »
Connect With Others
Posted by Anonymous, 1 Reply
...I was diagnosed with HPV and me and my boyfriend has been having unprotected oral sex. Can he catch HPV that way?
Read more »
Hpv and protected sex
Posted by Anonymous, 1 Reply
...How common is it to catch HPV from someone using a condom?
Read more »
HPV/Genital Warts
Posted by Anonymous, 2 Replies
...Hey, Whats up? My girl friend whom I've been with for a year now, recently got a pap smear done and she came up positive for HPV (abnormal cells). Me myself had been tested for STD's and a Visual Check up for HPV and in all tests I came up...
Read more »
relationship hpv & hiv
Posted by Anonymous, 1 Reply
...What is different between hpv and hiv. What is their relationship?
Read more »
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Phenomenal HousewivesHello. My name is Krissy and I have a blog about being a modern housewife. Throw in a few current event articles along with beauty, health,… Started by Kristina Grace |
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Young Living Essential Oils GiveAwayHello ladies. I'm so excited to be hosting a special Young Living Essential Oils Giveaway plus some extra surprises for those of yo… Started by Jasmine |
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Real Housewives? Did you watch?Are you a fan of Bravo's Real Housewives Series? Did you watch it last night? I think that Kim stabbed Nene in the back. I also think tha… Started by Harriet B |
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Authentic Italian Cuisine & Pizza
1400 Walter Redd Rd
Off the All American Freeway, beside Omni Health & Fitness
MON 11:00am - 10:00pm | TUE 11:00am - 10:00pm | WED 11:00am - 10:00pm | THURS 11:00am - 10:00pm | FRI 11:00am - 10:00pm | SAT 11:00am - 10:00pm | SUN 11:00am - 9:00pm |
Little Italy has been delighting its patrons for several years. We offer our customers a true touch of Italy right here in the heart of Fayetteville. Specializing in homemade pastas as well as a variety of meats and seafood. As a family owned and operated business, our guiding principles are hospitality, service, excellence, integrity, value and customer satisfaction. We cordially invite and welcome you to join us in a warm and relaxing setting for lunch or dinner. To all our patrons longstanding and new Buon Appetito and Mille Grazie from us here at Little Italy.
Category: Restaurants|Catering
THE BEST DINING EXPRIENCE !!! by Lucy B - 03/07/2012
If you are looking for authentic Italian food, this is the place to go ! We have never been disappointed in the three years we have enjoyed Little Italy. The recent additions to their wine list and menu have given us even more favorites to choose from. The service is top notch and they always remember us from the last visit and greet us by name. From the fantastic calamari appetizer, to homemade salad dressing , delicious entrees (Italian and seafood & steak), fresh baked bread, to the most wonderful desserts ever, you will leave full and happy. Thank you to Antonella, Joe and the service staff for always making sure we have a wonderful time at Little Italy. This is a must for everyone to go and enjoy!
Best Italian Menu in Fayetteville by Midnite's Mami - 05/24/2010
Thank you Antonella & Joe for opening such a fantastic authentic Italian Restaurant with a perfect location. On several occasions I have entertained friends, family, and business associates for lunch and dinner. Your friendly staff and excellent cuisine keeps us all coming back for more!
DexKnows Mobile profile for Little Italy Pizza in Fayetteville, NC


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Share your reviews,
photos and videos here!
Involvement:Expert (understands the inner workings) - Ownership:1 week to 1 month
Pros:It is very useful for my radio-electronic projects on my master courses. it was tested on frequencies up to 3 GHz. May be it will be work on frequencies more than 3 GHz. Amplitude nonlinearity is near 1 db on 1MHz to 1 GHz.
Cons:I had not a big problems with using it, but sometimes I need more longer connector than it, but it was not a problem.
OtherThoughts:Good price - good connector. Fixing in any box are normal. Used this connector with SMA-J-1.5 Coaxial Connector Adapter - Golden + Silver (5 PCS). Bought it secondary.
Bottomline:I recommend this device, because it is simple to use.
Get great weekly deals and offers like: Collections


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Michelle Alton 10/31/2010 3:33:55 AM
A beautifully composed image, with perfect execution! #1322650Marilyn Cornwell 11/15/2010 2:47:02 PM
Congratulations, Beck! A beautiful finalist!! #9037007Patricia A. Coblentz 11/15/2010 3:49:51 PM
Just gorgeous, Becky...big congratulations on your finalist! #9037657Renee Doyle 11/15/2010 3:58:06 PM
Beautiful tones!! Congratulations on this wonderful finalist Becky!! #9037747Lydia Williams 11/15/2010 4:07:18 PM
Wow, Congratulations on this beauty Becky! #9037870Randy D. Dinkins 11/15/2010 4:39:47 PM
Great pov and color, congratulations! #9038203Becky J. Parkinson 11/15/2010 5:07:17 PM
Thank you all! #9038454Phyllis Burchett 11/15/2010 5:33:33 PM
Congrats on this wonderful finalist! #9038691Debra R. Harder 11/15/2010 6:32:41 PM
I love your POV, Becky...and the details, textures and colors are amazing!! Huge congratulations on your BEAUTIFUL finalist!!! BTW...how do you like your D3s? Deb #9039096Sherran Andersen 11/15/2010 7:54:13 PM
Congrats Becky. #9039614Tiia Vissak 11/15/2010 10:39:31 PM
Congratulations! #9040087Irene Colling 11/16/2010 5:00:13 AM
Excellent POV, marked as a favorite of mine.Outstanding photography Becky, congratulations. #9040791
Daniella Puente 11/16/2010 4:32:51 PM
This is wonderful Becky, congrats! #9043101Mary L. Olson 11/17/2010 9:28:26 AM
Lovely image, Becky. You do such great work.Mary Lou #9045187
Sheila D. Robertson 11/17/2010 2:43:07 PM
Congratulations on this one too. I love the composition and tones. #9046219Merna L. Nobile 11/18/2010 8:37:15 PM
I would personally like to congratulate you on your winning photograph for October, 2010 and wish you a Happy Thanksgiving. Merna Nobile #9050057
Copyright for this gallery photo belongs solely to Becky J. Parkinson. Images may not be copied, downloaded, or used in any way without the expressed, written permission of the photographer.
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While Amazon is known to many for delivering CDs, books and foot spas, not many are aware that it has grabbed a sizeable chunk of the enterprise market too.
And now it seems eBay wants a slice of that enterprise action too. more»
While Amazon is known to many for delivering CDs, books and foot spas, not many are aware that it has grabbed a sizeable chunk of the enterprise market too.
And now it seems eBay wants a slice of that enterprise action too. more»
Smartphones and tablets have not just changed the way we shop online, they are also having an impact in brick-and-mortar shops, as many shoppers are using them to compare prices and read product reviews. But shoppers aren't the only ones doing a bit of intelligence work on the ground, the retailers are responding in kind. more»
It appears that Facebook is finally starting to make sense for marketers. For years Facebook users complained about every single redesign and the inclusion of more ads, especially intrusive ones that appear in newsfeeds.
However, it appears that they are working. more»
A report fresh out of Nielsen found that shoppers behave quite differently when they're doing their shopping on tablets rather than smartphones. Tablets are a lot more likely to be used for product browsing and tablet users write more product reviews. more»
British people are falling in love with e-commerce and a new eMarketer report claims their enthusiasm for buying things they don't need and can't afford with money they don't have will drive UK business-to-consumer e-commerce sales up to £62.49 billion this year. more»
Accenture has teamed up with Hubris to implement cross-border multichannel solutions more effectively. Accenture is now the sole global strategic partner of hybris, the world's fastest growing commerce platform.
The unholy alliance should combine Accenture's prowess in digital marketing, platform management and customer experience with hubris' leading omni-channel software. more»
Online retailers are on a roll, but many of their sites aren't performing well due to some rather basic technical limitations.
According to a recent report from NCC Group, the top 50 online retail sites in Britain exhibited poor website performance last quarter and much of the problems were caused by ancient internet connections. more»
The EU is looking for ways to help the retail sector and one of its tools could be a new cap on credit card fees. Although the European Commission has a chequered record in such matters, the new plan appears to resemble the EC's roaming caps, which were a success. more»
Physical retail outlets and e-commerce operations are starting to converge and consumers are starting to treat all channels as shopping, which it essentially is. Although high streets are suffering, e-commerce is becoming a force to be reckoned with, but e-commerce and brick-and-mortar retail are not mutually exclusive. more»
The United Kingdom is expected to end the year with a healthy £1.8 billion internet trade surplus, thanks to British internet retailers who adapted to online faster than their continental counterparts.
In a report called Modern Spice Routes, the Nielsen Company and PayPal worked out that the UK is going to spend £8.5 billion online internationally, but it will also sell £10.3 billion worth of goods and services. more»
Although online retail sales are still growing, new research from Mintel has revealed that growth is slowing quite rapidly. The online retail sector expanded by about 50 percent in 2008, but last year growth slowed down to just 15 percent. However, this is still much better than the rest of the retail sector and it means the UK online retail sector will double by 2018, with double-digit growth rates. more»
Calls for the introduction of a new online sales tax have been growing louder and unsurprisingly online retailers are having none of it. They believe any additional tax burden imposed on their businesses would be detrimental for people, for jobs and investment. more»
The online retail market in the UK is still going strong and according to IMRG Capgemini's latest figures it is growing at the fastest rate in two years. IMRG Capgemini's e-Retail Sales Index found that June sales rose 20 percent year-on-year. more»
Morrisons chief executive Dalton Philips believes the Government should impose a new online sales tax to level the playing field with its rivals and e-commerce outfits. Philips told The Daily Telegraph that the tax imbalance between internet and high street retailers is illogical and it is taking its toll on Britain's town centres. more»
The mobile wallet market is about to get big, huge even. According to a new report published by Transparency Market Research, the global mobile wallet market will reach $1,602.4 billion by 2018. In EMEA it will grow at a CAGR of 30.7 percent from 2012 to 2018 and EMEA will be the largest mobile wallet market in the world by 2018. more»


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Publications (136)367.19 Total impact
- 10/2013;
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ABSTRACT: The fibrinogen genes FGA, FGB and FGG show coordinated expression in hepatocytes. Understanding the underlying transcriptional regulation may elucidate how their tissue-specific expression is maintained and explain the high variability in fibrinogen blood levels. DNA methylation of CpG-poor gene promoters is dynamic with low methylation correlating with tissue-specific gene expression but its direct effect on gene regulation as well as implications of non-promoter CpG methylation are not clear. Here we compared methylation of CpG sites throughout the fibrinogen gene cluster in human cells and mouse and zebrafish tissues. We observed low DNA methylation of the CpG-poor fibrinogen promoters and of additional regulatory elements (the liver enhancers CNC12 and PFE2) in fibrinogen-expressing samples. In a gene reporter assay, CpG-methylation in the FGA promoter reduced promoter activity, suggesting a repressive function for DNA methylation in the fibrinogen locus. In mouse and zebrafish livers we measured reductions in DNA methylation around fibrinogen genes during development that were preceded by increased fibrinogen expression and tri-methylation of Histone3 lysine4 (H3K4me3) in fibrinogen promoters. Our data support a model where changes in hepatic transcription factor expression and histone modification provide the switch for increased fibrinogen gene expression in the developing liver which is followed by reduction of CpG methylation.PLoS ONE 08/2013; 8(8):e73089. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage. Histological examination of xenotransplanted livers has shown baboon platelet activation, phagocytosis and sequestration within the sinusoids. In order to study the mechanisms of platelet consumption in liver xenotransplantation, we have developed an in vitro system to examine the interaction between pig endothelial cells with baboon platelets and to thereby identify molecular mechanisms and therapies. Fresh pig hepatocytes, liver sinusoidal and aortic endothelial cells were isolated by collagenase digestion of livers and processing of aortae from GTKO and Gal+ MGH-miniature swine. These primary cell cultures were then tested for the differential ability to induce baboon or pig platelet aggregation. Phagocytosis was evaluated by direct observation of CFSE labeled-platelets, which are incubated with endothelial cells under confocal light microscopy. Aurintricarboxylic acid (GpIb antagonist blocking interactions with von Willebrand factor/vWF), eptifibatide (Gp IIb/IIIa antagonist), and anti-Mac-1 Ab (anti-α(M)β(2) integrin Ab) were tested for the ability to inhibit phagocytosis. None of the pig cells induced aggregation or phagocytosis of porcine platelets. However, pig hepatocytes, liver sinusoidal and aortic endothelial cells (GTKO and Gal+) all induced moderate aggregation of baboon platelets. Importantly, pig liver sinusoidal endothelial cells efficiently phagocytosed baboon platelets, while pig aortic endothelial cells and hepatocytes had minimal effects on platelet numbers. Anti-MAC-1 Ab, aurintricarboxylic acid or eptifibatide, significantly decreased baboon platelet phagocytosis by pig liver endothelial cells (P<0.01). Although pig hepatocytes and aortic endothelial cells directly caused aggregation of baboon platelets, only pig liver endothelial cells efficiently phagocytosed baboon platelets. Blocking vWF and integrin adhesion pathways prevented both aggregation and phagocytosis.PLoS ONE 10/2012; 7(10):e47273. · 3.53 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: To demonstrate that adenosine triphosphate (ATP), which provides a valuable biomarker for kidney viability in the context of donation after cardiac death (DCD) transplantation, can be detected by means of (31)P magnetic resonance spectroscopy (MRS) if kidneys are perfused with oxygenated hypothermic pulsatile perfusion (O(2)+HPP). Porcine kidney perfusion was carried out using a home made, MR-compatible HPP-machine. Consequently, kidney perfusion could be performed continuously during magnetic resonance imaging and magnetic resonance spectroscopy recording. (31)P MR spectroscopy consisted of 3-dimensional chemical shift imaging (CSI), which allowed for the detection of ATP level in line. (31)P CSI was performed at 3 tesla in 44 min with a nominal voxel size of 6.1 cc. (31)P CSI enabled the detection of renal ATP when pO(2) was equal to 100 kPa. With pO(2) of 20 kPa, only phosphomonoester, inorganic phosphate and nicotinamide adenine dinucleotide could be found. Semi-quantitative analysis showed that ATP level was 1.3 mM in normal kidney perfused with pO(2) of 100 kPa. This combined technology may constitute a new advance in DCD organ diagnostics prior to transplantation, as it allows direct assessment of ATP concentration, which provides a reliable indicator for organ bioenergetics and viability. In this study, kidneys presenting no warm ischemia were tested in order to establish values in normal organs. The test could be easily integrated into the clinical environment and would not generate any additional delay into the transplantation clinical workflow.MAGMA Magnetic Resonance Materials in Physics Biology and Medicine 05/2012; 25(5):391-9. · 1.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes (LIGHT; TNFSF14), and the inhibitory Ig family member B and T lymphocyte attenuator (BTLA). To dissect the differential contributions of HVEM/BTLA and HVEM/LIGHT interactions, topographically-specific, competitive, and nonblocking anti-HVEM Abs that inhibit BTLA binding, but not LIGHT, were developed. We demonstrate that a BTLA-specific competitor attenuated the course of acute graft-versus-host reaction in a murine F(1) transfer semiallogeneic model. Selective HVEM/BTLA blockade did not inhibit donor T cell infiltration into graft-versus-host reaction target organs, but decreased the functional activity of the alloreactive T cells. These results highlight the critical role of HVEM/BTLA pathway in the control of the allogeneic immune response and identify a new therapeutic target for transplantation and autoimmune diseases.The Journal of Immunology 04/2012; 188(10):4885-96. · 5.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Immunological barriers still preclude clinical xenotransplantation. The protective role of CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Treg) in allotransplantation is well described and, therefore, could represent a promising therapeutical tool for xenotransplantation. This review addresses the latest findings on Treg in xenotransplantation research. In vivo, costimulation blockade-based strategies including anti-CD154 monoclonal antibodies (mAbs) in combination with rapamycin or anti-LFA-1 mAb prolonged both concordant and discordant islets xenografts survival in a Treg-dependent manner. In vitro, IL-10 secretion was shown to be critical for the suppression of xenogeneic responses mediated by Treg. Moreover, transgenic expression of inducible costimulator-immunoglobulin or PD-L1 on porcine endothelial cells inhibited human T-cell proliferation in vitro and was associated with the induction of Treg and IL-10 secretion. CXCR3 mediated the recruitment of Treg to pig endothelium. Finally, the recruitment of human Treg was enhanced by the immobilization of human CCL17 on pig endothelium. There is increasing evidence for the potential of CD4(+)CD25(+)Foxp3(+) Treg to protect xenografts. Induction of Treg in recipients and/or recruitment of human Treg to pig endothelium may represent novel strategies to prevent cell-mediated rejection in pig-to-human xenotransplantation.Current opinion in organ transplantation 02/2012; 17(2):155-61. · 3.27 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Cytokine administration is a potential therapy for acute liver failure by reducing inflammatory responses and favour hepatocyte regeneration. The aim of this study was to evaluate the role of interleukin-1 receptor antagonist (IL-1ra) during liver regeneration and to study the effect of a recombinant human IL-1ra on liver regeneration. We performed 70%-hepatectomy in wild type (WT) mice, IL-1ra knock-out (KO) mice and in WT mice treated by anakinra. We analyzed liver regeneration at regular intervals by measuring the blood levels of cytokines, the hepatocyte proliferation by bromodeoxyuridin (BrdU) incorporation, proliferating cell nuclear antigen (PCNA) and Cyclin D1 expression. The effect of anakinra on hepatocyte proliferation was also tested in vitro using human hepatocytes. At 24h and at 48 h after hepatectomy, IL-1ra KO mice had significantly higher levels of pro-inflammatory cytokines (IL-6, IL-1β and MCP-1) and a reduced and delayed hepatocyte proliferation measured by BrdU incorporation, PCNA and Cyclin D1 protein levels, when compared to WT mice. IGFBP-1 and C/EBPβ expression was significantly decreased in IL-1ra KO compared to WT mice. WT mice treated with anakinra showed significantly decreased levels of IL-6 and significantly higher hepatocyte proliferation at 24h compared to untreated WT mice. In vitro, primary human hepatocytes treated with anakinra showed significantly higher proliferation at 24h compared to hepatocytes without treatment. IL1ra modulates the early phase of liver regeneration by decreasing the inflammatory stress and accelerating the entry of hepatocytes in proliferation. IL1ra might be a therapeutic target to improve hepatocyte proliferation.PLoS ONE 09/2011; 6(9):e25442. · 3.53 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: Polyclonal rabbit anti-thymocyte globulin (rATG) is widely used in solid organ transplantation (SOT) as induction therapy or to treat corticosteroid-resistant rejection. In vivo, the effect of rATG on natural killer (NK) cells has not been studied. These cells are of particular relevance after SOT because classical immunosuppressive drugs do not inhibit or even can activate NK cells. A cohort of 20 recipients at low immunological risk, that had been receiving rATG as induction therapy, was analyzed for receptor repertoire, cytotoxicity and capacity of NK cells to secrete IFN-γ before kidney transplantation and at different time points thereafter. NK cells expressed fewer killer-cell immunoglobulin-like receptors (KIR), fewer activating receptors NKG2D, but more inhibitory receptor NKG2A compatible with an immature phenotype in the first 6 months post transplantation. Both cytotoxicity of NK cells and the secretion of IFN-γ were preserved over time after transplantation.Clinical Immunology 11/2010; 137(2):250-60. · 3.77 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Statins act by reducing hepatic cholesterol synthesis, thus stimulating uptake of serum cholesterol. Statin therapy modulates a number of genes involved in hepatic cholesterol homeostasis. These have rarely been analyzed simultaneously in the same experimental setting, with virtually no studies of primary human hepatocytes. This study analyzed the efficacy of rosuvastatin in the coordinated regulation of a number of genes implicated in cholesterol metabolism in primary human hepatocytes. Expression of five cholesterol-related genes were significantly upregulated, notably the Niemann-Pick C1 like 1 protein, for whom functional studies have been essentially limited to the intestine. Two genes were significantly downregulated, including sterol recognition element binding protein-1 gene that is implicated in control of hepatic lipogenesis. The results show the coordinated regulation of several genes implicated in hepatic cholesterol homeostasis and suggest therapeutic targets that could complement that clinical action of statins.Pharmacogenetics and Genomics 07/2010; 20(7):455-8. · 3.45 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Pancreatic cancer is associated with a poor prognosis, and surgical resection remains the only chance for curative therapy. In the absence of metastatic disease, which would preclude resection, assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer. A frequent error is to misdiagnose an involved major vessel. Obviously, surgical exploration with pathological examination remains the "gold standard" in terms of evaluation of resectability, especially from the point of view of vascular involvement. However, current imaging modalities have improved and allow detection of vascular invasion with more accuracy. A venous resection in pancreatic cancer is a feasible technique and relatively reliable. Nevertheless, a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular invasion. Although the discovery of an arterial invasion during the operation might require an aggressive management, discovery before the operation should be considered as a contraindication. Detection of vascular invasion remains one of the most important challenges in pancreatic surgery. The aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer.World Journal of Gastroenterology 02/2010; 16(7):818-31. · 2.43 Impact Factor - Xenotransplantation 12/2009; 16(6):535-6. · 1.78 Impact Factor
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ABSTRACT: Immunosuppression is currently the treatment of choice to attenuate the chronic deterioration of tissue function as a result of the effector mechanisms of the immunological response in transplant rejection and autoimmune diseases. However, global immunosuppression greatly increases the risk of acquiring life-threatening infections and is associated with organ toxicity when used long-term. Thus, alternative approaches that inhibit only the unwanted immune responses and preserve general immunity are highly desirable. The receptor/ligand pairs involved in the cross-talk between DC and T cells have been the focus of intense and exciting research during the last decade. The HVEM/LIGHT/BTLA/CD160 costimulatory/coinhibitory pathway has emerged as a potential target for the development of immune therapeutic interventions. Herein, we will summarize and discuss how blockade of the costimulatory HVEM/LIGHT interaction or agonist signaling through the inhibitory BTLA and CD160 receptors could contribute to the control of deleterious immune responses.Journal of leukocyte biology 12/2009; 87(2):223-35. · 4.99 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The expression of interleukin 7 receptor alpha(high) (IL-7Ralpha(high)) discriminates between activated CD25(+)CD45RO(+)CD4(+) T cells [IL-7Ralpha(high) and forkhead box P3-negative (FoxP3(-))] and regulatory T cells (IL-7Ralpha(low) and FoxP3(+)). The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population has been shown to be expanded in the blood and tissues of patients after kidney transplantation and to contain alloreactive T cells (activated T cells). In the present study, we analyzed the distribution of IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cells in the blood of 53 patients after liver transplantation. The IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population was significantly expanded (P < 0.0001) in stable transplant recipients versus healthy donors. However, the magnitude of the expansion was significantly higher (P < 0.0001) in liver transplant recipients with no hepatitis C virus (HCV) infection in comparison with those with a preexisting HCV infection. Interestingly, effective suppression of HCV viremia after antiviral therapy was associated with an increase in the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population to levels comparable to those of liver transplant recipients not infected with HCV. The present results indicate that (1) the IL-7Ralpha(high)CD25(+)CD45RO(+)CD4(+)FoxP3(-) T cell population is expanded after liver transplantation, (2) it is a valuable immunological marker for monitoring activated and potential alloreactive CD4 T cells in liver transplantation, and (3) a preexisting HCV infection negatively influences the expansion of this population in liver transplant recipients.Liver Transplantation 10/2009; 16(1):49-55. · 3.79 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Acute pancreatitis is a potentially lethal inflammatory disease with an increased incidence and a decreased mortality rate. The main etiologies are biliary stones and alcohol abuse. The therapeutic approach consists of the elimination of the cause, the hemodynamic and respiratory supports and the treatment of the complications. Moreover, severe acute pancreatitis requires a collaboration between surgeons, radiologists, gastroenterologists and intensive care physicians. The administration of prophylactic antibiotics and the early oral nutritional support are still controversial. In summary, the anticipation in diagnosis, etiology, classification of the severity and early reanimation are needed for an optimal treatment of this complex disease.Revue médicale suisse 07/2009; 5(209):1425-30. - [Show abstract] [Hide abstract]
ABSTRACT: Multipotent mesenchymal stromal cells (MSC) are currently investigated clinically as cellular therapy for a variety of diseases. Differentiation of MSC toward endodermal lineages, including hepatocytes and their therapeutic effect on fibrosis has been described but remains controversial. Recent evidence attributed a fibrotic potential to MSC. As differentiation potential might be dependent of donor age, we studied MSC derived from adult and pediatric human bone marrow and their potential to differentiate into hepatocytes or myofibroblasts in vitro and in vivo. Following characterization, expanded adult and pediatric MSC were co-cultured with a human hepatoma cell line, Huh-7, in a hepatogenic differentiation medium containing Hepatocyte growth factor, Fibroblast growth factor 4 and oncostatin M. In vivo, MSC were transplanted into spleen or liver of NOD/SCID mice undergoing partial hepatectomy and retrorsine treatment. Expression of mesenchymal and hepatic markers was analyzed by RT-PCR, Western blot and immunohistochemistry. In vitro, adult and pediatric MSC expressed characteristic surface antigens of MSC. Expansion capacity of pediatric MSC was significantly higher when compared to adult MSC. In co-culture with Huh-7 cells in hepatogenic differentiation medium, albumin expression was more frequently detected in pediatric MSC (5/8 experiments) when compared to adult MSC (2/10 experiments). However, in such condition pediatric MSC expressed alpha smooth muscle more strongly than adult MSC. Stable engraftment in the liver was not achieved after intrasplenic injection of pediatric or adult MSC. After intrahepatic injection, MSC permanently remained in liver tissue, kept a mesenchymal morphology and expressed vimentin and alpha smooth muscle actin, but no hepatic markers. Further, MSC localization merges with collagen deposition in transplanted liver and no difference was observed using adult or pediatric MSC. In conclusion, when transplanted into an injured or regenerating liver, MSC differentiated into myofibroblasts with development of fibrous tissue, regardless of donor age. These results indicate that MSC in certain circumstances might be harmful due to their fibrogenic potential and this should be considered before potential use of MSC for cell therapy.PLoS ONE 02/2009; 4(8):e6657. · 3.53 Impact FactorThis article is viewable in ResearchGate's enriched format - [Show abstract] [Hide abstract]
ABSTRACT: Cytomegalovirus (CMV) infection is the most common viral complication after solid organ transplantation (SOT). Whilst current immunosuppression is known to impair antiviral-specific T-cell immunity in SOT, a potential role for natural killer (NK) cells not affected by immunosuppressive therapy remains to be determined. To address this, we compared the genotype of the NK immunoglobulin-like receptor (KIR) genes and their HLA cognate ligands to the rate of CMV infection in 196 kidney transplant recipients. We have shown that the absence of the HLA-C ligand for inhibitory KIR and the presence of activating KIR genes in the recipients were both associated with a lower rate of CMV infection after transplantation. In a cohort of 17 recipients with acute CMV infection, NK cells were phenotyped over a period of time after diagnosis by their expression profile of C-type lectin receptors and capacity to secrete IFN-gamma. The increased expression of the activating C-type lectin receptors NKG2C and NKG2D was paralleled by the decreased IFN-gamma secretion during the early phase of CMV infection. In conclusion, our findings suggest that KIR/HLA genotype and expression of NKG2C and NKG2D might play a significant role in regulating NK cell function and anti-CMV immunity after kidney transplantation.American Journal of Transplantation 01/2009; 8(12):2674-83. · 6.19 Impact Factor -
Article: Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.
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ABSTRACT: Previous studies have documented that the insulin-producing beta-cells of laboratory rodents are coupled by gap junction channels made solely of the connexin36 (Cx36) protein, and have shown that loss of this protein desynchronizes beta-cells, leading to secretory defects reminiscent of those observed in type 2 diabetes. Since human islets differ in several respects from those of laboratory rodents, we have now screened human pancreas, and islets isolated thereof, for expression of a variety of connexin genes, tested whether the cognate proteins form functional channels for islet cell exchanges, and assessed whether this expression changes with beta-cell function in islets of control and type 2 diabetics. Here, we show that (i) different connexin isoforms are differentially distributed in the exocrine and endocrine parts of the human pancreas; (ii) human islets express at the transcript level different connexin isoforms; (iii) the membrane of beta-cells harbors detectable levels of gap junctions made of Cx36; (iv) this protein is concentrated in lipid raft domains of the beta-cell membrane where it forms gap junctions; (v) Cx36 channels allow for the preferential exchange of cationic molecules between human beta-cells; (vi) the levels of Cx36 mRNA correlated with the expression of the insulin gene in the islets of both control and type 2 diabetics. The data show that Cx36 is a native protein of human pancreatic islets, which mediates the coupling of the insulin-producing beta-cells, and contributes to control beta-cell function by modulating gene expression.Human Molecular Genetics 12/2008; 18(3):428-39. · 6.68 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3-kinase signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN deletion in the liver leads to insulin resistance, steatosis, inflammation, and cancer. We recently demonstrated that unsaturated fatty acids trigger steatosis by down-regulating PTEN expression in hepatocytes via activation of a mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kappaB) complex, but the molecular mechanisms implicated in this process are still unknown. Here, we investigated potential genetic and epigenetic mechanisms activated by fatty acids leading to PTEN down-regulation. Our results indicate that unsaturated fatty acids down-regulate PTEN messenger RNA expression in hepatocytes through mechanisms unrelated to methylation of the PTEN promoter, histone deacetylase activities, or repression of the PTEN promoter activity. In contrast, unsaturated fatty acids up-regulate the expression of microRNA-21, which binds to PTEN messenger RNA 3'-untranslated region and induces its degradation. The promoter activity of microRNA-21 was increased by mTOR/NF-kappaB activation. Consistent with these data, microRNA-21 expression was increased in the livers of rats fed high-fat diets and in human liver biopsies of obese patients having diminished PTEN expression and steatosis. CONCLUSION: Unsaturated fatty acids inhibit PTEN expression in hepatocytes by up-regulating microRNA-21 synthesis via an mTOR/NF-kappaB-dependent mechanism. Aberrant up-regulation of microRNA-21 expression by excessive circulating levels of fatty acids exemplify a novel regulatory mechanism by which fatty acids affect PTEN expression and trigger liver disorders.Hepatology 12/2008; 49(4):1176-84. · 11.19 Impact Factor -
Conference Paper: Escherichia coli and Enterococcus faecalis Bacteriuria in Renal Transplant Recipients: Should we Treat all of Them?
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ABSTRACT: Background: Escherichia coli and Enterococcus faecalis bacteriuria are frequent after renal transplantation. Guidelines are missing for this population. Distinction between colonization and infection is rarely made, and as a consequence asymptomatic episodes are frequently treated without clear clinical benefit, with the risk of selecting resistant pathogens. Method: Retrospective analysis of 363 independent episodes that occurred in 100 renal-transplant recipients. Using strict criteria we distinguished upper (UUTI) and lower-urinary tract infection (LUTI), as well as high (HGC), intermediate (IGC) and low-grade colonization (LGC). Results: 100% UUTI were treated as compared to 64% LUTI, 45% HGC, 36% IGC and 11% LGC. In the absence of treatment 5% LUTI, 9% IGC and 5% LGC progressed to a more severe category, whereas spontaneous clearance of bacteriuria occurred in 75% LUTI, 49% HGC, 39% IGC and 65% LGC. Despite adequate antibiotic treatment persistent bacteriuria with selection of resistant bacteria occurred in 71% HGC, 61% IGC and 50% LGC. Microbiological cure was more frequent in treated as compared to untreated LUTI (P= 0.02), but tended to be more favourable for untreated than treated HGC (P=0.08). Conclusion: As in the non-transplant population, distinction between urinary tract colonization and infection seems adequate in renal-transplant recipients. A more restrictive treatment attitude for bacterial urinary tract colonization might not expose renal-transplant recipients to an excessive clinical risk, but might prevent the selection of resistant pathogens.Infectious Diseases Society of America 2008 Annual Meeting; 10/2008 - [Show abstract] [Hide abstract]
ABSTRACT: Baertschiger RM, Buhler LH. Xenotransplantation literature update March–April, 2008.Xenotransplantation 2008; 15: 277–280. © 2008 Wiley Periodicals, Inc.Xenotransplantation 08/2008; 15(4):277-80. · 1.78 Impact Factor
Publication Stats
2k | Citations | |
367.19 | Total Impact Points | |
Top Journals
- Xenotransplantation (35)
- Transplantation Proceedings (16)
- Transplantation (13)
- Transplantation (8)
- Xenotransplantation (7)
Harvard Medical School
- Department of Surgery
Boston, Massachusetts, United States
University of Geneva
- • Department of Surgery
- • Division of Transplantation
Genève, GE, Switzerland
Centre universitaire romand de médecine légale Lausanne - Genève (CURML)
Genève, Geneva, Switzerland
Hôpitaux Universitaires de Genève
- • Service de chirurgie viscérale
- • Unité d'investigations chirurgicales
- • Département de chirurgie
Genève, Geneva, Switzerland
Universidad de León
León, Castille and León, Spain
Sichuan University
Hua-yang, Sichuan, China
University of Pittsburgh
- Department of Surgery
Pittsburgh, Pennsylvania, United States
Massachusetts General Hospital
- Transplantation Biology Research Center
Boston, Massachusetts, United States


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Mr. Skipper is The Best !!!!Submitted by 123 (not verified) on Thu, 11/03/2011 - 11:58am.
Mr.skipper is a great pricipal at Topsail high school he has been my principal for the past couple years since middle school he's a very kind,gentlemen he do not deserve to be put under something he didnt do. I think they should vote new peoples in the Board Eductation cause they full of it .I Do attend topsail high school to this day »
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