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Sunday Dugout Discussion
Filed under: Dugout Discussion - Posted by: Mark
Sunday delivers a double header of lip-smacking ties, as old rivals United and Liverpool clash at Old Trafford, whilst Arsenal host City in the four o'clock kick-off. With a host of big Fantasy assets on show, our Dugout Discussion chatroom is now open to catch the real-time yelps and cries as events unfold.
The team news for the lunchtime kick-off finds Sir Alex Ferguson opting for the experienced pairing of Nemanja Vidic and Rio Ferdinand at the back, with Jonny Evans reportedly missing out with a hamstring problem. Elsewhere in the United lineup, Danny Welbeck is drafted in, along with Shinji Kagawa as Antonio Valencia and the rather unfortunate Javier Hernandez drop to the bench.
Visitors Liverpool make just one change: Joe Allen comes into the midfield with Jordan Henderson dropping out. Andre Wisdom again occupies the right-back role, then, with Glen Johnson deployed at left-back. Both Daniel Sturridge and the returning Fabio Borini find places on the bench.
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Is it time to get Nasty? grrr...
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England's CM choices:
Maybe these as well:
Good luck selecting two Hodgson- 2 years, 1 month ago
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I already have Walcott, thinking of getting Cazorla for the DGW and transfer him out after that. Worth it?
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"Last year was quite open for me, I was in good positions, but I was quite lucky because I was getting free kicks and some penalties as well."
Yaya Toure Manchester City midfielder
- Mark @FFScout_Mark
- Paul @ffscout_paul
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- Demi @FFScout_Demi


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These authors contributed equally to this work.
Original Article
Prognostic relevance of BRD7 expression in colorectal carcinoma
Article first published online: 7 DEC 2012
DOI: 10.1111/eci.12024
© 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation
Additional Information
How to Cite
Eur J Clin Invest 2013; 43 (2): 131–140
Publication History
- Issue published online: 18 JAN 2013
- Article first published online: 7 DEC 2012
- Accepted manuscript online: 12 NOV 2012 06:22AM EST
- Manuscript Accepted: 7 NOV 2012
- Manuscript Received: 10 OCT 2012
- Abstract
- Article
- References
- Cited By
- bromodomain;
- prognosis;
- colorectal cancer
BRD7 is a member of bromodomain-containing protein and was found to be a cofactor of P53. Down-regulation of BRD7 has been shown in nasopharyngeal carcinoma cell lines and tissues. However, the clinical role of BRD7 in colorectal cancer remains unknown.
Materials and methods
Real-time PCR, Western blotting analysis and immunohistochemistry were employed to examine BRD7 expression in CRC cell lines/tissues compared with normal epithelia cells/adjacent non-tumorous tissues. In addition, statistical analyses were applied to evaluate the diagnostic value and associations of BRD7 expression with clinical parameters of patient samples.
BRD7 was down-regulated in colorectal cancer cell lines and cancerous tissues compared with that in normal colon epithelial cells and adjacent noncancerous tissue samples. BRD7 protein expression was positively correlated with clinical stage (P < 0·001), T classification (P = 0·001), N classification (P < 0·001), M classification (P < 0·001) and pathologic differentiation (P = 0·008). Patients with low/none BRD7 expression had shorter overall survival time than those with higher BRD7 expression. Univariate and multivariate analyses indicated BRD7 expression was an independent prognostic factor (P < 0·001).
BRD7 may serve as a potential prognostic biomarker of human colorectal cancer.

subset: commoncrawl


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So we talk about MIL and Dh and SO and everyone, but does anyone have a grandpa who steps up??? We call my family grandpa (dh's father) the baby whisperer. When DD cries, he doesnt even think of handing her off. He is the most amazing grandpa alive. Anyone else wanna share theirs being lovey with LO?
Can we give Grandpas some credit?!?!?! *PIC* thread
Posted 12/02/2012
Classic! Of course my dad would be the one to introduce my daughter to the computer at only 1 week old!!
What's on your mind?
Create a new postYour growing child
Your 28-month-old: Making friends
First friendships are very real to your child. Read More


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Hostel Absteige Reviews
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The rating percentage is calculated from customers who booked within the last 12 months.
All ratings and reviews are based on the feedback and opinions of the customers who submitted them and do not express the opinions of Hostelworld.com. This way, you get an up-to-the-minute opinion of just how good a hostel really is.
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It was complicated to find the hostel, the instructions weren´t clear, and the hostel bulding is under construction so, there were sings to find the entrance, we look all around the building and we didn´t find it, we were about to leave and find another hostel. We ask to the guys that were in the construction, but nobody could tell us where it was, until some guys appear and help us to find the entrance and ask for somebody can check us in We lose almost an hour of our time Didn´t accept CreditC
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I was there in the middle of the reconstruction.
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This is more of an apartment than a hostel. No staff members, just one man that is never really around. No kitchen or common room or washing facilities. I definitely wouldn't recommend staying there as a solo traveller! Good location so if you have a group it would be okay.
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BED BUGS!!!! if you like to be bitten all night long - wellcome
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e spirit collection of lnoue Takehiko Vol.1 Vagabond Musashi
Prices are automatically linked to market prices in Japan, some rare items are more expensive than regular price.
In Stock
Inventory information is updated once each day. All products are new.
- Asia (SAL Parcel): US$25.05
- Oceania,North America,Central America,Middle East (EMS): US$36.07
- Europe (EMS): US$41.41
- South America,Africa (SAL Parcel): US$55.10
Product Shipping Estimate:
[How to Calculate Shipping Cost (?)]
You may be subject to import duties and taxes. [... more info (?)]
- Weight: 1.798kgs
- Package Size: 20cm x 39cm x 23cm
- Manufactured by: TK Holdings
- Release Date: Sunday 20 December, 2009
Height approx 29cm


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GLENDALE, Ariz. — Even though it's spring training where everyone is relaxed and jovial, Paul Konerko detects a different attitude in the clubhouse.
White Sox Daily Digest: Monday, March 17, Day 31 of 41
Today's game: at Milwaukee Brewers, 3:05 p.m. CST
GLENDALE, Ariz. -- Josh Byrnes feels a certain sense of pride that Adam Eaton and Matt Davidson were acquired to be part of the White Sox foundation.
TEMPE, Ariz. — Some of Matt Davidson's enthusiasm can without question be attributed to rookie exuberance.
PHOENIX — The White Sox have had to do more roster shuffling as Jeff Keppinger's surgically repaired shoulder is behind schedule.


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To find the parts that fit your machine, click on the link below and select your make, year and model.
Only the products that fit your machine will be shown in the product list
Click Here to Add Your Machine! >>
The Moose Racing License Plate Holder is made of aluminum construction. Measures 8" x 4". Comes complete with all mounting hardware. Made in the U.S.A.
Specifications and Options


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Description: This is a simple 2x3 male PTH header. This header is in the common configuration for an ISP connector. Each pin has a spacing of 0.1" in between each other.
Where is this on the Sparkfun eagle library… I seem to have a lot of trouble finding things on the eagle library, is there some sort of guide i can refer to? Thanks! :D
Suppose you have a board or schematic, and you're adding a part (command "add"). You should then get a little dialog with on the left a list of libraries and on the right some preview information (if a part is selected). Below the list on the left is a search field - try entering key words from the part's name in there.
In this case, entering "2x3" should at least give you SparkFun-Connectors > 2X3, which happens to be the part required and is an exact match for the name.
If you enter "*2x3*", you'll get parts that mention 2x3, like SparkFun-Connectors > 2X3_LOCK (which is intended for the same part, but has pads slightly offset from each other so that you can insert this part, flip the board over for soldering, and not worry about the part falling out.)
If that doesn't work, try other key words, in this case e.g. "*header*", or even the part's ID "*12807*" (many, but not all, components are have their SparkFun ID added).
If all else fails - and I've certainly had that happen - try using an external search application that can search through files for certain text. As of Eagle version 6, all the libraries are XML plaintext, and you can often find a part that way if the above methods don't work. You then have to scroll around a bit in the file to figure out exactly what the part is named, but after that you can just go back to the Eagle search facility :)
For additional guidance, see also;
Using EAGLE: Schematic: Adding Parts to a Schematic
Do you have available the 2x3 SMD headers that are used on the Redboard?
+RobertC how about a preformed 2xN header strip that one side of the pins is bent 90° twice so that each side will plug neatly into the center of a breadboard?
I just have to say, that's a really nice picture. Sure, it's a common and inexpensive part, but someone took the trouble to light and crop it and make it look its best. I'll go so far as to point out I would buy a T-shirt with this image on it.
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text: Enjoyed walking around the greenery and seeing the sculptures and trees. Saw more wildlife there than we did in El Yunque! It was free and easy to access (you do have to follow the driving directions - it is not the kind of place you just happen by, and the roadside signs are a bit rough) It was a perfect... More


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Local high schoolers greet voters at election sites
November 7, 2013 MAYVILLE — "He can't be old enough to vote," may very well have gone through the minds of voters Tuesday when they are greeted at area poll sites by local high school seniors. more »»
Local restaurant celebrates 80 years in business
October 31, 2013 Calarco's began at the close of prohibition as one of the first two licensed bars in the area. more »»
Westfield Academy & Central School Academic All Star Luncheon
October 31, 2013 Westfield Academy & Central School Academic All Stars were recently honored at a luncheon on October 24, 2013, at Quagliana's Bark Grill. Academic All Stars must achieve high honor roll status (94. more »»
HPW Energy receives award
October 31, 2013 The County Executive's Award for Innovative Energy Initiatives was presented to HPW Energy at their location, at the Barcelona Market and Cafe in the town of Westfield, by County Executive Greg... more »»
Ninth annual 'Walk 4 Paws' event raises $33,000
October 31, 2013 JAMESTOWN — The Chautauqua County Humane Society announced the fundraising totals from their ninth annual Walk 4 Paws. more »»
Mayville seniors
October 24, 2013 Forty-three people met at the Mayville VFW for lunch Oct. 17 to enjoy the music of Carl Witherow's Northeast Banjo Band. They played old favorites like Rocky Top, Whole Wide World, and In Your Hand. more »»
Officers elected
October 24, 2013 Officers for the Larueate Alpha Pi Sorority have been chosen for the 2013-2014 year. more »»
Rotary District Governor Crouse visits Westfield
October 24, 2013 Rotary 7090 District Governor Kevin Crouse recently visited the Westfield/Mayville Rotary Club and was greeted by John Hamels, club member who is assistant district governor; Crystal Schrantz, club... more »»
WMH Auxiliary Soup Supper set
October 24, 2013 It's back – by popular demand! The Westfield Memorial Hospital Regional Auxiliary will again host a Soup Supper. The event will be held on Election Night, Tuesday, Nov. more »»
Christmas Craft Bazaar
October 24, 2013 FINDLEY LAKE — The Alexander Findley Library will hold their annual Christmas Craft Bazaar on Saturday, Nov. 2 from 10 a.m. to 4 p.m. at the Findley Lake Fire Hall on Main Street. more »»
County Chamber Corner
October 24, 2013 Call your county legislator – urge a YES vote to sell the County Home - By Todd J. more »»
Army National Guard soldier from Sherman promoted
October 24, 2013 LATHAM, N.Y. — Major General Patrick A. more »»
Melanie Titzel to appear on Senior Report
October 24, 2013 Senior Report with Reed Powers will have Melanie Titzel as the guest on the Oct. 26 television program. Titzel will discuss senior living communities. The live, call-in program airs from 9-10 a.m. more »»
Brocton to shorten length of fire whistle at night
October 17, 2013 By Ann Belcher firstname.lastname@example.com BROCTON — Those awakened by the Brocton Fire Department's fire whistle may have some sort of relief following a recent village board meeting. more »»
I-86 rest area volunteers attend Grape Discovery
October 17, 2013 WESTFIELD — The Chautauqua County Visitors Bureau treated the volunteers that staff the Information Window at the Chautauqua Lake Rest Area on I-86 in the Town of Ellery to a special luncheon... more »»
Mayville seniors hold meeting
October 17, 2013 Oct. 3 — Forty-two people met for lunch and a meeting at the Mayville VFW dining hall. Joyce Ayers welcomed everyone and Virginia Scriven gave the invocation. more »»
Regional tours highlight colors of Chautauqua Fall Learning Festival
October 17, 2013 Fall foliage and harvest season set a colorful and vibrant scene for vacation and lifelong learning in Western New Yor. more »»
Robert Ducato Elected Lt. Governor of Kiwanis Southwestern Division
October 17, 2013 Robert "Bob" Ducato, has been elected to serve the Southwestern Division of Kiwanis for the administrative year Oct. 1, 2013 through Sept. 30, 2014. more »»
Hometown Heroes
October 17, 2013 Air Force Airman 1st Class James G. Privateer graduated from basic military training at Joint Base San Antonio-Lackland, San Antonio, Texa. more »» |
News, Blogs & Events Web |


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Jungle Numbers #20
Fight off crocodiles, cross bridges, and discover a hidden temple in this number ordering worksheet. Kids will gain practice with number recognition as they arrange three digit numbers in the correct order from least to greatest or greatest to least. As a final challenge, students will fill in the missing numbers as they approach a hidden temple. Order numbers and more in this jungle-themed math worksheet.
Updated on Feb 24, 2014
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Old Version of phpMyAdmin 4.1.0 (Beta 1)
Legacy OS support
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phpMyAdmin 4.1.0 (Beta 1) (8.1 MB) |
45 scans reported this version clean |
Sponsored Links
- Windows XP
- Windows XP x64
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- Contains new features and fixes
Screenshots are not available for this software
phpMyAdmin is a tool written in PHP intended to handle the administration of MySQL over the Web. Currently it can create and drop databases, create/drop/alter tables, delete/edit/add fields, execute any SQL statement, manage keys on fields, manage privileges,export data into various formats and is available in 50 languages.
Updates : phpMyAdmin Updates
Did You Know?
phpMyAdmin is a web administrator's tool of sorts, it is a PHP script meant for giving users the ability to interact with their MySQL databases. A "raw" view of the data, tables and fields stored in the MySQL database is accessible through this great tool.


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There's been a lot of talk recently about the LDS Church baptizing the souls of Jews who died during the Holocaust. The Church has been controversial for posthumous baptisms in the past, and AP writers Deepti Hajela and Jennifer Dobner explain that the Church has volunteered to take action to change its "massive genealogical database" [...]
read more
The Mormon Church has apologised for posthumously baptizing the parents of Nazi-hunter Simon Wiesenthal. But the controversy over its un-biblical practice of posthumous proxy baptisms the dead continues. Read Post
The Mormon church has apologized for the posthumous baptism by its members of the parents of famed Nazi hunter and Holocaust survivor Simon Wiesenthal. Read Post
Holocaust survivors said Monday they are through trying to negotiate with the Mormon church over posthumous baptisms of Jews killed in Nazi concentration camps, saying the church has repeatedly violated a 13-year-old agreement barri... Read Post


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WholeFoods Magazine SourceBook: The Natural Products Directory
Vitamin Angels hosted its Twenty Year Celebration at the VIP Diamond Club at Angel Stadium of Anaheim.
Natural Products Expo West drew more that 67,000 industry members March 6–9 to the Anaheim Convention Center in CA, a 5% growth from the previous year. The show floor was larger, too, hosting 2,600+ exhibiting companies and more first-time exhibitors (635 in total) than in 2013.
Crowd funding has blazed a trail for entrepreneurs to make their dreams a reality. But how do you convince strangers to willingly donate thousands of dollars to the promise of a product or service? And with new platforms popping up everyday how do you know which is right for you?
Global ID Group, a co-founder of the Non-GMO Project and technical administrator of the group, launched a new initiative at Expo West.
Acquisitions, mergers, awards, charity, certifications, company news and more.
Promotions, new hires, retirements and more.
Silver Spring, MD—A recent increase in shipments of the herb kratom to the United States has caught the attention of the U.S. Food and Drug Administration (FDA).
Washington, D.C.—The Federal Trade Commission (FTC) has won $2.2 million it its lawsuit against supplement maker Wellness Support Network Inc. (WSN) for making false or unsupported claims about its diabetes supplements.
Jarrow L. Rogovin, president of dietary supplements manufacturer Jarrow Formulas, Inc., based in Los Angeles, CA, is seeking answers about some recent practices at the U.S. Food and Drug Administration (FDA).
Silver Spring, MD- The Food and Drug Administration (FDA) has released their its proposed Nutrition Facts label to replace the current one that has been deemed outdated.
Retailers had better wake up to the realities of today...
Kaiseraugst, Switzerland — ...
Los Angeles, CA—The Institute for...
all products


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Planar Announces Preliminary Financial Results For Its Fiscal Second Quarter And Updates Its Expectations Regarding Certain Financial Results For The Full Fiscal Year 2012
The Company plans to report final financial results for its fiscal second quarter 2012 and provide additional information regarding other expected financial results on May 2, 2012.
Planar Systems, Inc. (NASDAQ: PLNR) is a global leader in digital display technology providing premier solutions for the world's most demanding environments. Retailers, educational institutions, government agencies, businesses, utilities and energy firms, and home theater enthusiasts all depend on Planar to provide superior performance when image experience is of the highest importance. Planar solutions are used by the world's leading organizations in applications ranging from digital signage to simulation and from interactive kiosks to large-scale data visualization. Founded in 1983, Planar is headquartered in Oregon, USA, with offices, manufacturing partners, and customers worldwide. For more information, visit www.planar.com.
"Safe Harbor" Statement under the Private Securities Litigation Reform Act of 1995: This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 relating to Planar's business operations and prospects, including statements relating to the Company's expected levels of revenue, gross profit, operating expenses, restructuring charges, operating income, Non-GAAP loss, and/or profit, and cash for the second quarter of fiscal 2012, the fourth quarter of fiscal 2012, the second half of fiscal 2012 and the entire 2012 fiscal year. These statements are made pursuant to the safe harbor provisions of the federal securities laws. These and other forward-looking statements, which may be identified by the inclusion of words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "goal" and variations of such words and other similar expressions, are based on current expectations, estimates, assumptions and projections that are subject to change, and actual results may differ materially from the forward-looking statements. These statements are not guarantees of future performance and involve certain risks and uncertainties that are difficult to predict. Many factors, including the following, could cause actual results to differ materially from the forward-looking statements: poor or further weakened domestic and international business and economic conditions; changes or continued reductions in the demand or order rates for products serving the various display markets served by the Company; any delay in the timing of customer orders or the Company's ability to ship product upon receipt of a customer order; the extent and timing of any additional expenditures by the Company to address business growth opportunities; any inability to reduce costs or to do so quickly enough, in either case, in response to lower-than-expected revenue; the ability of the Company to successfully implement its intended cost reduction plan and reduce on-going operating expenses as much as planned; adverse impacts on the Company or its operations relating to or arising from any inability to fund desired expenditures, including due to difficulties in obtaining necessary financing; changes in the flat-panel monitor industry; changes in customer demand or ordering patterns; changes in the competitive environment including pricing pressures or the ability to keep pace with technological changes; technological advances; shortages of manufacturing capacity from the Company's third-party manufacturing partners or other interruptions in the supply of components the Company incorporates in its finished goods including as a result of natural disasters like the recent earthquakes and tsunami in Japan; future production or sales variables resulting in excess inventory and other risk factors listed from time to time in the Company's periodic filings with the Securities and Exchange Commission (SEC). The forward-looking statements contained in this press release speak only as of the date on which they are made, and the Company does not undertake any obligation to update any forward-looking statement to reflect events or circumstances after the date of this press release.
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Our Mission
NHLA's mission is to fulfill America's promise of equal justice by providing civil legal services to New Hampshire's poor, including education and empowerment, advice, representation, and advocacy for systemic change.
Latest News
Applications for NH property tax relief are due March 1
Fair Housing Update January 2015
Communications and Outreach Manager joins NHLA and the Campaign for Legal Services
NHLA Appoints new Deputy Director
We offer our clients high quality civil legal services to address the legal problems that affect their daily survival and most basic needs. These services range from simple legal information and advice to vigorous and thorough representation in all of New Hampshire's courts and before many of the local, state and federal agencies which play large roles in their lives. In providing legal services to the poor, NHLA helps balance the scales of justice for all citizens.
Our Offices
Treated with respect...
I was treated with respect and importantly everyone genuinely listened to what I had to say. That is rare now a days.
NHLA Needs Your Support
NHLA relies on the goodwill and support of the entire community to
reach our mission of equal access to justice for all people in New
Hampshire. Your financial support strengthens our organization and our
ability to serve those in need. Use the link above to make a safe, and
secure donation or if you prefer send your tax-deductible donations
(checks can be made to the Campaign for Legal Services) to:
New Hampshire Legal Assistance
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Inquiries about making a donation can be sent to:


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Security Guard: Requirements for a Career As a Security Professional
Security guards monitor sites to prevent theft, vandalism, fire and other harmful situations. They're responsible for maintaining the safety of employees, residents, guests and all people within an assigned location. Security guards may be required to use force against violators, and some guards are armed with handguns, handcuffs, pepper spray and other law enforcement tools.
Security Guard Requirements
In many states, security guards are required to obtain licensure. Eligibility varies by state, but most licensure applicants must be 18 or older, have a clean criminal record and pass a drug test. Security guards may be required to complete formal training in a classroom setting. Licensure qualifications are generally stricter for armed security guards, who must also obtain firearms licensure.
Education Requirements
There are no strict education requirements for becoming a security guard. Employers prefer to hire applicants with at least high school diplomas or the equivalent. Some positions, such as those in casino security or investigation, require postsecondary degrees or certificates.
Some community colleges and technical schools offer security guard training programs that lead to certificates. Many of these programs are designed to fulfill state licensure requirements, and vary in length according to state regulations. They typically consist of a basic training course that covers first aid, patrol techniques, disaster response, crowd control and ethics, among other fundamental topics. Certificate programs' curricula may also incorporate hands-on, practical training on job sites and yearly continuing education courses.
Undergraduate Degree
Certain employers may prefer applicants with postsecondary degrees. Undergraduate degrees in criminal justice, law enforcement science or other applicable fields may give security guards an upper hand in the search for employment. Associate of Applied Science in Criminal Justice programs, for example, prepare students for entry-level positions in law enforcement. Courses may include investigation techniques, security management, psychology, juvenile justice and criminal law.
On-The-Job Training
Security guards typically obtain instruction on the job, in which case training duration and depth vary by employer and job duties. They may learn protection and defense methods, as well as how to write reports, deliver first aid and handle emergency situations. Security guards who carry weapons generally complete more exhaustive training than those who are unarmed, and they may learn firearm safety and force laws. Those who work in high-security settings often endure extensive training followed by strict supervision on the job.
American Society for Industrial Security (ASIS) International Training Guidelines
Some employers implement the training standards set forth by ASIS International, which recommends that trainees receive 48 hours of instruction in the first 100 days of service. Under ASIS International guidelines, trainees must pass examinations that assess proficiency in topics like crime prevention, emergency procedures, evidence management and report writing. They may also be required to complete annual continuing education courses.
Employment Outlook and Salary Info
In May 2013, the U.S. Bureau of Labor Statistics (BLS) reported that security guards earned a median hourly wage of $11.57, or $24,070 annually. Jobs for security guards were predicted by the BLS to grow 12% from 2012-2022, mainly due to the ongoing need for protection of property and people.
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Cleanfax Insider
The Cleanfax Insider is the #1 online weekly informational resource center for all carpet cleaning, upholstery cleaning, business management and marketing challenges. Keep up-to-date with best practices, breaking news and trends.
Easy Pickings
Don't leave your valuable customers hanging. Your competition is eager to snatch them from you.
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Article Preview
District 16 Democrats to meet April 12
Published 04/04/2012, West Fargo Pioneer
The District 16 Democratic-NPL Party will hold their next monthly meeting on Thursday, April 12 at 6 p.m. at Caribou Coffee on 13th Ave in West Fargo.
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AAE53200 - Orbit Mechanics
Fall 2018Days/Time: MWF / TBA
Credit Hours: 3
Learning Objective:
Introduce students to spacecraft orbital dynamics and the issues associated with orbital control and station keeping. Primary focus in regimes where two-body analysis and conics are a valid model. Computation and implementation of impulsive maneuvers in three dimensions; transfer orbits and Lambert's theorem to support discussions of mission trajectory design. Impact of the trajectory on other subsystems.
Natural behavior of planets and moons in the solar system as well as spacecraft motion: orbit dynamics, perturbations, and stability; trajectory control, on-orbit maneuvers, and transfers; mission design, patched conics.
Topics Covered:
1. Introduction to the laws of Kepler and Newton; universal gravitation and integrals of motion.2. Fundamental concepts associated with the two-body problem and conics; orbital elements.3. Orbital maneuvers: (1) orbit establishment; (2) single impulse adjustments; (3) multiple impulse transfers including Hohmann transfers, local gravity fields and flybys, Hoelker and Silber transfers, Lambert time-of-flight theorem, three-dimensional transfers; (4) mission design issues.4. Orbital perturbations including Euler-Hill equations for two-close orbiters and some navigational issues.
1. Calculus and differential equations through ODEs 2. Vector mechanics; particle/rigid body kinematics and dynamics; three-dimensional coordinate systems and transformations 3. Some introduction to perturbations and linear algebra 4. Numerical methods and tools such as MATLAB.
Web Address:
Web Content:
Syllabus, Grades, Lecture Notes, Homework Assignments and Solutions.
Homework 55%
Three exams.
No textbook required. Disclaimer: Final textbook listings are available in April for fall and summer semesters. Please visit the Listing of Textbooks by College or School for the most up-to-date information.
Computer Requirements:
ProEd Minimum Computer Requirements
ProEd Minimum Requirements: view
Tuition & Fees: view
Kathleen C. Howell
765 494-5786
Purdue University
Neil Armstrong Hall of Engineering
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West Lafayette, IN 47907-2045
Instructor HomePage
765 494-5786
Purdue University
Neil Armstrong Hall of Engineering
701 W Stadium Ave
West Lafayette, IN 47907-2045
Instructor HomePage


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World Oilfield Forum
man that other crew did a good job last night
Now yall keep it going
oh look its raining everyone into the dog house
more like when it rains "for all you who have slicker suits get out there and work. For those who dont get out there and help them
Last week I would have thought this was funny...but I had a hand go down for heat exhaustion Tuesday... So people will hear about this allot around my iron from now on. So definitely...if its too hot take a fkn break or you're stupid...or dead.
© 2015 Created by Drilling Ahead.


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3 de 202 résultat(s) pour Rénovations (Wellington Station PE): Évaluez les résultats
199 de 202 résultat(s) pour Rénovations autour de Wellington Station PE:
Trent Pollard Inc
Trent Pollard Inc. is an experienced & trusted home builder & renovator located on beautiful PEI.Our clients have relied on us to provide on time & on budget new homes & renovations & additions
Gallants Home Renovations
Gallants Home Renovations takes pride in our work & customer service, we can handle all your renovation needs! We look forward to working with you to achieve your reality.
MRJ Construction Ltd
MRJ Construction Ltd. is a licensed & insured construction company specializing in home renos, decks, roofs and much more. Serving Stratford and Greater Charlottetown area. Quality work done right!
McGuirk Bros Construction Ltd hermitage
Insist on Quality - Custom Built Homes, Additions, Renovations - Residential, Commercial & Agricultural
Southern Kings Construction LtdFacsimile
Southern Kings Contruction offers the best quality in general and building construction services. Residential, commercial, industrial, renovations, concrete work and foundations.
Bulldog Demolition
We have the equipment, experience and expertise necessary for any kind of job: recycling, demolition, snow removal, shore erosion protection, hydrocarbon soil cleanup, environmental services & more.
D and L Contracting Ltd
D and L Contracting Services for Bordon, Bedeque, Summerside, Central Queens and East Prince counties of PEI. Quality services and reasonable prices. Contact Dirk for free estimate
Arsenault Bros Construction
Over 20 years experience and extensive knowledge in carpentry, framing (steel&wood), drywall, seam filling, walls and ceilings, doors/windows/hardware, insulation/vapour barrier, etc.
Hilchie Quality Homes
Whether your taste & requirements are contemporary, traditional, or somewhere in the middle, our professionals at Hilchie have the experience to build or renovate the property that fits your lifestyle
O'Brien Construction And Rénovations
"We have over 25 years of quality service. We specialize in new homes, kitchens & baths, windows, doors & siding, roofing, decks as well as historical rehabilitation and so much more…"
Scotcor Construction Ltd
"Exceeding your Expections. We're proud of each and every one of the homes we build, and consistently exceed customer expectations!"
Queen's County Construction Ltd
MacLellan's Construction & Home Renovations
Dean Arsenault Construction
No Job too BIG or small, we quote them all. Fully insured Renovation SPECIALIST. From a full blown renovation to installing a new deck or fence.Call us today


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Stationery Cards
Set of folded stationery cards printed on bright white, smooth card stock to bring your personal artistic style to everyday correspondence. Each card is blank on the inside and includes a soft white, European fold envelope for mailing.
Thank you catspaws! My new-found fascination with owls - for a really long time, I used to despise them - but somehow in the recent past, I've taken some time to keenly observe them.
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If you are looking for the ultimate location for your wedding reception, party or special occasion, why not come to Lodge Hill? Set in 32 acres of woodland...
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More information on Lodge Hill's 2015 events: 17th February - Activity Day for Disabled Children and their families - 11am - 3pm, £5 per...
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LIMITED SPACES BOOK EARLY TO AVOID DISAPPOINTMENT CONTACT TODAY Colleen 01798 831411 colleen@lodgehill. org....
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There's plenty of adventure and team building activities for everyone to enjoy. From climbing to mountain biking, orienteering to archery, and much more. Why not make it a weekend trip and stay in our on-site accommodation?
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Take your business out of the 'hustle & bustle' and over to our woodland retreat. We have spaces available to hire for conferences, meetings or corporate functions to suit any occasion.
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ChallengeU is a unique outdoor activity based early intervention programme for young people who have disengaged with society or education, including those who have offended or who are in danger of offending.
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Charity Dance "Remembering 1945" A Great Success!
Saturday 28th February at Riverside Caravan Park, Bognor was the "Remembering 1945" charity dance and big band evening in aid of Lodge Hill. The evening was organised by Bognor Hotham...
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SEASONAL GENERAL ASSISTANTS REQUIRED Things are getting busy at Lodge Hill! Reliable casual/flexible staff needed between March/November 2015 Weekday, evening, school holiday & weekend...
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Toyota Links
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Toyota Tacoma For Sale
2004 Toyota Tacoma Trims For Sale
User Reviews
Displaying 1 - 10 of 16 2004 Toyota Tacoma reviews.
2004 Toyota Tacoma 2 Dr V6 4WD Extended Cab LB
ProsExcellent commuter vehicle, but with the power and the 4WD, it also makes an excellent utility vehicle. Low maintenance, decent MPG ConsHave not found anything wrong with this vehicle
Owned 100% — This is an outstanding line of vehicles, I imagine if I ever sell this truck I'll probably buy another Tacoma. I've added a transmission fluid radiator and Ride Rite air bags on the rear axle for towing. I've also added a cold air intake and after market exhaust/muffler. This vehicle has an aftermarket infinity head unit, upgraded speakers and added a sub-woofer. I love this truck and I've instructed my wife to have me buried in it! Primary Use: Commuting to work
Looking for a Used Tacoma in your area?
CarGurus has 23,122 nationwide Tacoma listings
starting at $2,200.
2004 Toyota Tacoma 4 Dr V6 4WD Crew Cab SB
ProsTowed trailers as large as 3500lb camping pop-ups, U-haul, etc. holds 1 yard of compost, several bikes, camping gear, dogs, etc. good gas mileage for a v6 truck, 18-20mpg. ConsTowing up long hills is difficult. Also, controlling speed on downhills with trailer causes front brakes to overheat.
Would Buy Again — Great truck that could do most anything. Never stuck in snow or sand. Good mileage for any 4wd v6 truck. Low cost maintenance. No issues after 200,000 miles! Would be nice to have a manual option. Go out and get one! Primary Use: Family transportation |
2004 Toyota Tacoma 4 Dr Prerunner V6 Crew Cab SB
ProsEasy to drive and quite fun too! ConsGas and changing the spark plugs.
2004 Toyota Tacoma 4dr Trd — Performs above average and has a nice flow-master system. Build quality is amazing. This is a well built truck. Appearance is awesome. good combination of lift, tires, and rims. Cost is about that of an average car. About 16 avrg. mpg. This car is fun to drive and take on easy trails. I would recommend this truck as a good buy, and it holds its value. |
2004 Toyota Tacoma 2 Dr V6 4WD Extended Cab LB
Prosits sporty but can hall alot and it looks good too Consit may be too much for a person who has always had a two door coupe.
I Aint Never Getting Rid Of It — it is awesome off roadin in this truck bone stock. It is incredible what stock toyota parts will go through. Its an awesome year too. The last year of the model is usually the best and toyota hit it right this time. |
2004 Toyota Tacoma 2 Dr V6 4WD Extended Cab LB
ProsGoes just about anywhere. Sounds nice with good exhaust. ConsCan be a bit slow. Rattles from random places, not the best ride, but hey, it's a truck, so quit whining.
2004 Toyota Tacoma
I Own One. I'll Never Buy Another Toyota Product Again. — A. the trailing edge of the flimsy hood vibrates wildly at certain engine speeds making a hideous rattling sound.Apparently, the geniuses at toyota can't seem to find the right size rubber support to cushion the hood.I fixed it though. B. I go through front brake pads ( the right front wears much faster that the left) every 22,000 miles. According to the dealer there is nothing wrong. According to independent service shops, all toyota trucks have front calipers that are exceptionally prone to sticking and wearing the pads prematurely.The calipers have to be cleaned and lubricated every 6000 miles or so to prevent them from sticking. C. good luck getting anything covered under the toyota warranty. Owner for 3 years, 3 months Miles Driven per Year:15,000 |
2004 Toyota Tacoma 4 Dr V6 4WD Crew Cab SB
ProsI like the small size of the truck and low maintenance cost ConsThe ride is not very comfortable for long distance
Nice Around The Town Truck — I would recommend this truck for someone that likes to have the cargo space of a small truck - but doesn't tow or haul. It is a great run around town vehicle with 4WD, but I would not recommend long distant travel in it. Primary Use: Family transportation |
2004 Toyota Tacoma 4 Dr V6 4WD Crew Cab SB
ProsGood looking body styling ( not a big fan of the 2005 and up styling changes ) and legendary Toyota reliability. Truck purchased used with 112K miles and have no doubts that I will see another 200K ConsNot much on comfort and fuel mileage isn't the best but still a nice, reliable truck with plenty of power for towing and every day driving. The short, 5' bed ( standard with the 4 door crew cab ) is too small for hauling but, couldn't pass up the deal on this truck with low miles.
Great Truck ! — I sold my 2005 Nissan Frontier 4X4 and regretted it ever since. Funny thing, before I bought my Frontier, I sold a 1993 Toyota and bought a new 2001 Tacoma that I wasn't very fond of after buying it. In 2005 I bought my Frontier and by 2012, with 105K miles on it, I was looking for something with better MPG so sold the Frontier and looked for my next truck -- an older Frontier maybe ? Maybe an older Tacoma ? I figured I would "know it" when I saw it and I looked for several months at a lot of different trucks before I found this one. ALL of the trucks I have EVER owned have been manual transmissions but, this one is an automatic so that my wife can also drive it. We don't drive it often or very long distances ( only putting about 1000 mile on it in the last three months ) but, it's a nice looking truck, plenty of power and I know that I won't have to worry about it getting us where ever we need to go. Primary Use: Utility (towing boats, transporting cargo, etc.) |
2004 Toyota Tacoma 2 Dr V6 4WD Extended Cab LB
Prosif you drive offroad, have heavy snow. Great truck gets great mpg ConsNo need to own a Offroad package if you dont use it, rides hard.
Buy It If You Need A Smaller Pickup Truck And 4wd. — Gets 22mpg, strong V6 engine, 4wd with offroad package. Sound sounds great! comfort is good, quality is great. Put 110,000 miles on the truck and have only needed to change the battery. No complaints here other than the fact that the TRD offroad package makes the truck ride a little rough. Primary Use: Commuting to work |
2004 Toyota Tacoma 2 Dr STD 4WD Standard Cab LB
ProsOff roading made fun and easy ConsWarranty issues
Tacomas Fun On And Off Road — The build quality sucked. Which is why I sold it after the local dealership denied services. Found out later that I could have gone through Toyota of America as the dealership had had a lot of complaints at that time. All of the bells and whistles were included in this package. Locking rear axle, 4wd, optional passenger airbag for babies or off-roading and many other things I don't remember any longer. Now these features are sold separately. A 2004 or older sr5 tacoma is definitely the model to go with. The mileage was poor however. At 10mpg, I sold it. The vehicle had a lot of torque and would easily squeel the tires at starts. Very fun to drive. The wheel base is a bit long and made taking sharp corners a bit difficult. Primary Use: Sport/fun (spirited driving, track racing, off-roading, etc.) |
Displaying 1 - 10 of 16 2004 Toyota Tacoma reviews.
Reviews From Other Years
2014 Toyota Tacoma Reviews
Americans Want Bigger Economy Trucks To The Point There Is No Longer Economy Trucks That Get 30 Mpg By pickupman
It's like riding on a cloud compared to my 94 Toyota pickup that I still have. When I heard they wasn't making a 2015 Toyota with a regular cab, I went to the dealer and actually got a nice price on a... Read More
Basic Tacoma. They Improve A Little Every Year. By robet
The cabin feels open for it's size. I drive easy and regularly get 23-25 miles a gallon in mixed driving. The roll up windows were easy to get used to on the driver side though I miss a passenger ... Read More
2013 Toyota Tacoma Reviews
Excellent Little Truck By MrOstrich
A nice looking vehicle that can carry moderate loads. Comfortable and practical interior. Good road handling manners. Weak 4-cylinder engine - have to really push it at highway speeds. Recently purcha... Read More
Best Midsize Truck On The Market By Maloneya
I've had my Tacoma for a little over a year now and use it as my farm/work truck. It's been loaded down with lumbar, firewood, concrete, cinderblocks, you name it, I've used it to tow heavy trailers, ... Read More
2012 Toyota Tacoma Reviews
Big Red. It May Be A Little Truck But It Is Tough. By nmortenson
I love that we can fill up the truck and go for drives and not have to worry about going into debt filling it up. It is comfortable and has perfect handling to go on any kind of road. We use it to pul... Read More
Impressions On Downsizing Trucks. By ptronsgard
I love the maneuverability and outstanding traction in snow. This truck does better than my 4WD GMC 2500 in deep snow. I used my Tacoma to get my GMC out from being hung up last winter. My wife even e... Read More
2011 Toyota Tacoma Reviews
Amazing, Incredible, Best Buy, Holds Value! By Jshaw405
It is an incredible vehicle. I love Tacoma's, can't say it enough! I have taken this off road, on road, on snow, on ice, on wet roads, it performs great! Make sure and get the truck bed cover, comes i... Read More
This Taco Eats Its Competition By cpisto
Bridges the gap between a small work truck and the full-sizers. Very useful for quickly loading camping gear, kayaks, bikes etc. Perfect vehicle for the adventuring type. If you are looking for a stoc... Read More
2010 Toyota Tacoma Reviews
Best Pick Up On The Market By bshannonvt
I loved everything about this cal. It is super versatile and survives in the worst of conditions. The bed is a great size and has been able to fit mattresses, bikes, as well as construction equipment.... Read More
Solid Little Truck By rd5590
The overall build quality is excellent. There were no fit and finish issues at delivery. It has surprisingly strong acceleration. It is a fun little 5 speed that is reasonably comfortable for short to... Read More
People researching a 2004 Toyota Tacoma contacted a dealer about
57% of the time
Nissan Frontier
9% of the time
Toyota Tundra
7% of the time
Ford Ranger
7% of the time


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#79905Fri, 22 Aug 20142 commentsListen to a new Terekke jamListed appropriately as 'dusty house music,' "Yrlv" is the lead cut from the producer's next 12-inch for L.I.E.S.aaroncoultate
#73117Tue, 10 Dec 2013Post a commentTerekke mix for Welcome To The RoomThe L.I.E.S. artist features on the 40th Welcome To The Room mixHousetunes
#68709Thu, 5 Sep 20137 commentsMeet TerekkeThis video from Mines Clarence finds the L.I.E.S. artist in his natural habitat: on the couch, surrounded by hardware in his Brooklyn apartment.Max_Cherry
Tue, 24 Feb 2015Post a commentWeird Magic launches record label with Purple Trax compilationThe Brooklyn promoter and blog has corralled exclusives from Terekke, Traxman and Logan Takahashi.
Fri, 20 Feb 20153 commentsTerekke takes to the roadL.I.E.S.' dusty hardware maven will play four North American dates this month.
Wed, 18 Feb 20151 commentDonato Dozzy billed for Inner Varnika 2015Mr. Ties, DJ Sotofett and Terekke will also play the Victorian camping festival over Easter.
Wed, 4 Feb 20156 commentsOutput announces Techno ValentineThe Zenker Brothers and Anthony Parasole will play alongside Frank & Tony and Terekke.
Sun, 1 Feb 20155 commentsPacific Rhythm opens Vancouver storefrontThe online record seller will set up shop in Chinatown next Saturday, and they'll kick it off with a party.
Mon, 14 Jul 2014Post a commentL.I.E.S. hits Tilburg for Incubate 2014Ron Morelli and his crew will play two label nights in conjunction with Bunker Records.
Thu, 3 Jul 2014Post a commentSteve Summers debuts in Australia this JulyThe L.I.E.S. producer will play four shows this month.
Wed, 25 Jun 20144 commentsElectrosanne announces 2014 lineupLaurent Garnier, Ben UFO and Hudson Mohawke will all hit Switzerland in September.


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A little price for a lot of cover – Asda Pet Insurance. Now you can afford to insure your four legged friends, thanks to 3 different levels of cover from Asda Pet Insurance. Dogs start from £8.65* a month and cats from £3.95*.
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Wireless infrastructure operators and original equipment manufacturers (OEMs) continue to demand expanded capacity, performance and flexibility in network planning and management. Cost-effective solutions that provide a smooth transition from 2G to 3G and 4G protocols have become a necessity. With our latest OP6000 Digital Front-End (DFE) processor family, Broadcom delivers unparalleled linearization performance for 2G, 3G and 4G protocols and advances the ability for base station design, deployment and management to meet this Multi-Protocol demand. The Universal DFE™ OP6000 family of processors is able to process multiple protocols or mix of protocols. This enables the creation of flexible platforms that can adapt dynamically to future network requirements.
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Broadcom Announces Industry's First Fully Integrated Chip for Virtual Customer Premise Equipment
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Broadcom Enables New Denon Google Cast™ Ready Multi-room Wireless Sound System
Delivers Seamless Whole Home Audio Streaming over Wi-Fi


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BUFFALO, N.Y. -- Despite leading Grand Rapids in scoring, Chris Conner knows he wasn't called up to provide a big offensive boost. Instead, he's looking to give the Red Wings a little jolt.
"I want to bring some energy and speed," said Conner, who was recalled from the AHL Griffins to play in the 4-1 win at Buffalo Friday night. "They want me to come in and do anything I can to help the team win and be successful."
Coach Mike Babcock wants the 5-foot-8, 180-pound forward to provide quality minutes on the penalty-kill unit and use his persistence to cause some commotion in the offensive zone. ...


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6:00 PM ET, November 29, 2008
MIAMI -- Sherell Hobbs scored 15 points, leading Auburn (No. 16 ESPN/USA Today, No. 15 AP) past North Carolina State 66-51 on Saturday in the opening round of the FIU Thanksgiving Classic.
DeWanna Bonner added 14 for Auburn (6-0), which will play the host Golden Panthers (1-4) on Sunday. FIU beat NC State 58-42 on Friday in the other opening-round game of the three-team event.Shayla Fields led NC State (4-3) with a game-high 23 points and seven rebounds. Brittany Strachan added 11 for the Wolfpack.Auburn went on a 12-0 run in the first half to take a commanding 35-16 lead following a basket by Bonner and took a 39-24 lead into halftime.NC State pulled within 50-43 in the second half, but that would be as close as the Wolfpack would get.


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Check out the sights and sounds from Super Bowl XLII.
Check back for more on the action in Arizona. In the meantime, also
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"Yeah, my girl loves anal," your pal casually let loose over a few beers and, since then, you've been dreaming about slipping it inside your lady's rear passage. She's down to try (and you have) but until she's anally taken as many dicks as have the women of new Naughty America site, My Girl Loves Anal, you'll probably still be dreaming. Why not enjoy some vicarious thrills provided by the likes of Julia Ann, Eva Karera, Jennifer White, and Juelz Ventura, all of whom are not only eager for a filling, they've got one particular orifice in mind.
Japanese women have long held a strong hold on the fantasies of Western men. Legendary for their submissiveness, their servitude, their eagerness to please, their tight snatches, the women of Japan are celebrated in decadent hardcore style here at Erito. Although suffering from the same visual censorship most hardcore J-porn suffers from, Erito's four sites are nonetheless loaded with carnal delights covering all mainstream acts and the more out-there, more adventurous fetishes and kinks. But can Erito's stunning array of Japanese babes indulging their sexually wild sides make a strong enough impact without offering a single video for download?
Interactive DVDs, choose-your-own-adventure sites, and masturbation sleeves molded on pornstar pussies all tried to give you, the porn fan, exactly what you want: mastery of your sexual impulses and the acts and women that satisfy them. DollHouse Films might have a title that suggests it's your own personal porno playground, but in fact it's a darkly seductive semi-hardcore site that sees gorgeous babes of the adult world donning heavy black eye makeup, clamping and chaining their nipples together, and staring into the darkest recesses of your sexual imagination. What a delight!
At Teeny Black, Team Skeet's sole website with an African American focus, you'll find a dozen gorgeous young black girls getting their start in porn. Seducing you and their onscreen partners into fairly simplistic but passionate and powerful sex scenes, the girls look stunning in 1080p High Definition video formats. But with so few updates currently available, just how can Teeny Black hope to keep you coming back for more and more and more?
After ten years of producing the finest British, European, and American hardcore porn money can buy, Harmony Films now goes online at Harmony Vision and presents fans and members with HD videos, A-list starlets, and the some of the most depraved yet strangely classy hardcore on the 'net. As a new site still finding its sea legs, Harmony Vision doesn't satisfy all user demands, but it's getting closer and closer with every passing day.
When presented with a chance to make his mojo work its magic on Japanese twins Fook Mi and Fook Yu, Austin Powers finds himself interrupted by his superior and can only utter a single word in protest, "Twins!" That same close sibling relationship is the driving force behind Lane Sisters, a site celebrating the work of Shana and Roxy Lane, Canadian twin pornstars who are set to light your taboo-fantasizing fire on this, their very first website.
It's not just their remarkably large penises that have ensured horses will be included in discussions of human sexuality for all time, it's their aggressive yet majestic temperament. Raging Stallion is a gay porn company so sure of its work that it named itself after the most intensely horny animal image known to man, that of the bucking bronco hell bent on inseminating its mare; or, in this case, another stallion with a puckering asshole that might just finally be ready for a pounding. Raging Stallion won't blow anyone's mind, but it does deliver solid gay hardcore at a good price and with little extraneous nonsense. Now, if only the webmasters would add some downloads, then this wildly bucking horse would really be a wild ride!
So, you've Just Gone Gay. Now what? Hell, if you're in the same situation as most of the rest of the world, you probably wanna earn some money, right? In that case, you're much like the brand-new-homos of Just Gone Gay. They too dropped to their knees and made some quick cash shooting porn. Hosting an exclusive collection of homo-hardcore that'll have you tickling your taint and kneading your knob almost immediately upon entry, Just Gone Gay takes one devoted cock-gobbler and introduces him to a guy who has only just come to terms with his homosexuality, pushing them together for some frisky frolicking of the carnal kind.


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Directions - The Cotford Hotel, Malvern
3 | AA Assessed Hotel | Ratings explained |
DirectionsView directions provided by hotelFrom the North... Railway:Great Malvern Malvern Link Colwall Ledbury Attractions:The Theatre of Small Convenience Great Malvern Station Worcestershire Beacon Three Counties Showground |


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Androgen Receptor : Dynamics, Structure, Function and Associated Pathologies
Sleeping Giant: How antibiotics turn off protein synthesis and put ribosome to sleep
Prix Alexandre Joannidès 2014 Académie des sciences : Irwin DAVIDSON
The TAF2-TAF8-TAF10 complex forms in the cytoplasm before it enters into the nucleus of the cell and joins TFIID-precursor.
Jan. 14, 2015
The international team coordinated by Imre Berger (EMBL) and Làszlò Tora (IGBMC) just demonstrated that the TFIID transcription factor, which controls the gene transcription in eukaryote cells, starts to assemble in building blocks in the cytoplasm before penetrating into the nucleus.
These results - published January 14, 2015 in Nature Communications - open up a new way for research on gene regulation and defects during transcription.
In normal cells (A), iron import (through transferrin and its receptor) is sufficient to support the production of heme and iron-sulfur (Fe-S) clusters. The energy supplied to the cell is thus sufficient and most IRP1 proteins contain an Fe-S cluster.
In the absence of frataxin (B), the productions of heme and Fe-S clusters are less efficient. IRP1 devoid of Fe-S cluster then activates cellular iron import to support mitochondrial iron needs. Frataxin-deficient cells have less energy than a normal cell, but iron accumulation act as a compensatory mechanism that aims at increasing heme and Fe-S cluster productions.
Feb. 4, 2015
The mitochondrial iron accumulation observed in Friedreich's ataxia was thought to be noxious. Hélène PUCCIO's team at the IGBMC has just demonstrated that this accumulation rather allows to partially compensate for the absence of frataxin. Resulting of a modification of the IRP1 protein activity, this accumulation supports the biogenesis of iron-sulfur clusters (Fe-S) and heme in mitochondria.
These important results regarding the cellular adaptation in the absence of frataxin also question the validity of therapeutic approaches aiming at neutralizing the cellular iron accumulation observed in Friedreich's ataxia.
This work is published in Cell Metabolism on February 3rd, 2015.
Upon PKD activation (A), insulin granules generated at the Golgi of pancreatic beta cells are released at the plasma membrane (in yellow in the scheme and in the electron microscopy picture). Upon fasting, PKD1 gets inactivated (B) and insulin granules fuse with lysosomes (in purple) that contain enzymes required for degradation of insulin : in parallel activation of mTOR suppresses autophagy.
Feb. 20, 2015
Roméo RICCI's team at the IGBMC recently demonstrated that the pancreatic beta cell, responsible for proper insulin secretion, responds in a very distinct way to nutrient withdrawal. The beta cell, in contrast to most other cells, does not digest its own cellular structures (a process known as autophagy) to generate its own nutrients when they are not available from the environment. Instead, autophagy is actively suppressed and replaced through a newly discovered process in beta cells, the specific digestion of freshly made insulin granules. While this cellular process is an important adaptation to fasting, its deregulation may contribute to type 2 diabetes.
This discovery in beta cells may thus open new therapeutic perspectives in the treatment of diabetic patients. This work is published on February 20th 2015 in Science Magazine.
The Vitamin D receptor (VDR) activates numerous genes following binding of bioactive vitamin D (calcitriol, A).
Gemini analog bound to the mutated receptor VDRgem have similar effects (B).
On the other hand, VDRgem cannot bind calcitriol (C). This induces a repression of numerous genes and leads to rickets that are more severe than in the absence of the receptor.
Jan. 22, 2015
Having identified precisely how vitamin D binds to its receptor, a study coordinated by Natacha Rochel and Dino Moras (Department of Integrated Structural Biology, IGBMC) and Daniel Metzger (Department of Functional Genomics and Cancer, IGBMC) explains the severe skeletal defects of patients carrying mutations of this receptor and osteoporosis due to vitamin D deficiency.
The researchers indeed showed that the absence of Vitamin D binding to its receptor leads to a more severe calcium deficiency than in the absence of receptor. Their results, published on January 22nd 2015 in Cell Reports, also pave a way to identify Vitamin D analogs for the treatment of various pathologies like osteoporosis, neuro-degenerative and autoimmune diseases, as well as cancer.
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Kat Von D and Jesse James deny they've split, are "still going strong"
By Elizabeth Kwiatkowski, 06/17/2011
Kat Von D and Jesse James have denied reports they've split, claiming their relationship is better than ever.
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"That day can't come soon enough!"
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x The average starting price for a place to stay in Branson is £47 per night.
21 Stillwater
Excellent 90%2350 Green Mountain Dr
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Excellent 90%3015 Green Mountain Dr
Excellent 90%2384 Shepherd of the Hills Expressway
Excellent 90%2651 Shepherd Of The Hills Expy
Excellent 90%3027-A West 76 Country Blvd
Excellent 90%2693 Shepherd of the Hills Expressway
Excellent 90%2400 Green Mountain Drive
Excellent 90%2422 Shepherd of the Hills Expway Missouri
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LAKEWOOD, NJ — Former New Mexico Highlands University baseball standout Freddy Flores has been hired as head softball coach of Georgian Court University, the school announced this week.
Georgian Court University Director of Athletics and Recreation Laura Liesman broke the news in a release issued Tuesday afternoon.
Roman Andrade made four of four foul shots and teammate Kelvin Franklin hit both of his free throws over the final 30 seconds Saturday night to seal New Mexico Highlands' 76-73 road victory over Colorado School of Mines.
NMHU improved to 8-5 overall and 2-3 in Rocky Mountain Athletic Conference play while also snapping a two-game slide.
Chris Dunn had tied the contest at 67-67, also via two free throws, with 2:13 left. A couple possessions later, Chop Tang knocked down a three-pointer.
West Las Vegas girls' basketball coach Jose "Majic" Medina had seen it before — a Lady Dons team falling behind by a few points in a big game, getting caught up in the moment, its collective confidence shaken, and letting a small deficit turn into a gaping chasm from which there would be no escape.
Not this time.
On Christmas Eve, I was involved in a one-vehicle rollover accident near San Geronimo. I was trapped in my SUV, hanging upside down by the seatbelt. Hot coffee had spilled all over me and was rapidly freezing. I did not have a coat on and the sun had dropped below the Sangre de Cristos with darkness fast approaching.
Now Las Vegas voters will decide on a new constitution for the city government.
On Wednesday, the City Council voted 3-1 to present a proposed city charter to voters in the March 2 municipal election.
The council approved the proposed charter drafted by the Charter Commission, whose 11 members were appointed by the mayor, the council and the municipal judge.
Over the last two months, the council twice rejected the proposed charter because a majority of members didn't like the provision for runoff elections.
San Miguel County Treasurer Alfonso Ortiz will be the only candidate for Las Vegas mayor in the March election.
It's the first time in recent memory that a non-incumbent has run unopposed for the city's top spot. Another rarity is that no city incumbents are running for re-election.
Filing day for municipal candidates was Tuesday.
In December, Ortiz, 69, who served as a councilman in the 1970s and 1980s, announced that he would run for mayor.
GOLDEN, Colo. — Angie Charchalis drained a pair of free throws in the final five seconds to help secure a 60-58 win for Colorado School of Mines over visiting New Mexico Highlands on Saturday evening in Rocky Mountain Athletic Conference action at Lockridge Arena.
Twice in the final minute, the Cowgirls (6-6 overall, 1-4 RMAC) slashed the lead to three points before running out of time.
In one of the bigger moments in program history, West Las Vegas rocked Lovington 72-55 in girls basketball Friday at Gillie Lopez Gym. Both teams tied for No. 1 Wednesday in the NMHSCA poll of Class 3A. West's win makes the Lady Dons 11-1. See Monday's Optic for details.
New Mexico Highlands 125-pounder Seth Wright upset the No. 1-ranked wrestler in NCAA Division II in a competitive but ultimately unsuccessful dual meet Friday at Adams State College in Alamosa, Colo.
The Grizzlies, rated No. 10 in the nation, won the dual 29-15.
Wright's effort in a 9-4 decision over national finals regular Arsenia Barksdale was one highlight for the Cowboys and coach Doug Moses, who returned to the mats after the holiday break. Wright is now 5-1 overall.
The latest New Mexico High School Coaches Association polls have a number of area basketball teams rated among the best in the state.
West Las Vegas' Lady Dons top the list, ranking No. 1 among the state's Class 3A girls' squads. WLV is tied with Lovington, whom the Lady Dons host on Friday afternoon at Gillie Lopez Gym. West is coached by Jose "Majic" Medina.
Robertson's Lady Cardinals are ranked eighth in the same poll after a recent run to the championship game in a Roswell Goddard tournament.


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Van Gundy: Kentucky can't top Wiz
Updated: March 29, 2012, 11:32 PM ET
Associated Press
NEW YORK -- Stan Van Gundy said Wednesday the notion that Kentucky could beat an NBA team is "absurd."
The Orlando Magic coach was asked about comments by former Maryland coach Gary Williams, who told a Washington radio station he thought the Wildcats could beat the NBA's Washington Wizards in one game at Rupp Arena.
The Wildcats, the favorites to win the NCAA championship, have multiple players who are expected to be NBA lottery picks. Forward Anthony Davis could be the No. ...
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Willowbrook 61, Marmion 58: Marmion led by 4 points at halftime, but a 22-15 third quarter spurt carried the Warriors to a non-conference road victory. Jordan Glasgow contributed a team-high 15 points for the Cadets (3-7) with Kevin Kavanaugh and Matt Smith adding 9 points each. Tiger Greene led all scorers with 17 points for Willowbrook (3-6).
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text: Sol Umag Hotel Quick Specs Commissions 10.0%Rates $168-$226Year Built 1964Year Renovated 2003 View Large Interactive Map Address Jadranska bbUmag, Croatia 52470 Web http://www.istaturist.hr Phone + 385 52-714000 Fax + 385 52-714999 Toll-free 800-336-3542 Email email@example.com OverviewMeeting SpecsPhotos & videos Description On beach w/direct view of the sea, in resort area.Year Built: 1964Year Renovated: 2003Check in Time: 12:00 PMCheck out Time: 12:00 PMNumber of Floors: 8Total Number of Rooms: 270Rates: $168Commissions: Room Only 10.0%Chain: Melia Hotels InternationalChain Website: http://www.melia.com GDS Hotel Reservation CodesAmadeus GDS: SM PUYUMASabre GDS: ME 006749 Sol Umag Hotel Location & NeighborhoodNear Umag, 80 kilometers from Pula. On beach w/direct view of the sea, in resort area. Rural, Suburban, Tourist. Sol Umag Hotel Rates & PoliciesSol Umag Hotel rates are Daily in USDStandard: $168 Suite: $226 (USD) Credit Cards Are AcceptedReservations must be guaranteed with a credit cardMeals: Full Breakfast IncludedDeposit Policy: Groups due to according; individual guests not necessaryCancellation Policy: Anytime by the end of the dayHotel Discounts offered: Group discount Nearby AirportsDei Legionari Intl (26 miles north)Pula (42 miles southeast)Rijeka (48 miles east)More Airports » Sol Umag Hotel Room AmentitiesSol Umag Hotel amenities are in All rooms unless noted otherwiseAir ConditioningBalcony/TerraceCoffeemaker (some)Daily Maid ServiceRooms for Non-smokersTelephoneRefrigeratorCable/Satellite TelevisionTelevisionInternet Access (Wireless) Guest ServicesBarber/Hair StylistCar RentalCurrency ExchangeGift ShopLaundry RoomLaundry/Dry Cleaning ServiceMulti-lingual StaffFree Onsite ParkingWheelchair Access to Common/Public AreasCommon Area Internet Access (Wireless) Security ServicesSmoke Alarm in Rooms Pet ServicesPets Allowed On-Site RecreationBeachHealth ClubHealth Spa/MassagePool (Children's Pool, Indoor Pool, Outdoor Pool)Tennis (Outdoor Tennis)Nearby RecreationBicyclingBoating/SailingFishingGolf CourseHorseback RidingJogging TrailsScuba DivingShopping Mall/AreaSnorkelingWater Skiing Sol Umag Hotel Meeting Rooms & Events5 Meeting Rooms Sol Umag Hotel Business ServicesBusiness CenterCopierFaxMeeting Room Internet Access (Wireless) Sol Umag Hotel Images, Videos, & Virtual Tours Photos & Videos Sol Umag Hotel ExteriorSol Umag Hotel ExteriorSol Umag Hotel LobbySol Umag Hotel LobbySol Umag Hotel RoomSol Umag Hotel RoomSol Umag Hotel PoolSol Umag Hotel PoolSol Umag Hotel MeetingSol Umag Hotel MeetingSol Umag Hotel RestaurantSol Umag Hotel RestaurantSol Umag Hotel SuiteSol Umag Hotel SuiteSol Umag Hotel Health ClubSol Umag Hotel Health ClubSol Umag Hotel SpaSol Umag Hotel Other Images Powered by VFM Leonardo Nearby Umag Hotels More Nearby Hotels Hotel DelfinHotel Laguna MediteranHotel Laguna MateradaKempinski Hotel AdriaticHotel LagunaSol AuroraSol Garden IstraSol PolynesiaSol Stella MarisGrand Hotel PalazzoHotel Laguna Gran VistaHotel Laguna MolindrioHotel Plavi PorecIsabella CastleMaistra Resort BelvederePical HotelSunset Lanterna ApartmentsZagreb HotelNaturist Solaris Residence Hoteliers! Is your listing up to date? With over 130,000 hotels in our database, no other source compares to our depth of information. Click here to review and be sure the travel professional knows your hotel's latest details.


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Archive for Wednesday, April 30, 2008
Aunt Norie's Sewing Room
April 30, 2008
Some tips and reminders from one of our long-time readers, Anna Mary Landauer.
Anna Mary, like so many of us, remembers the Depression days, those tough times when everyone appreciated even the little things, when no one wasted anything.
Those waste-not-want-not days when everyone considered "a penny saved a penny earned." She sews on or replaces buttons with a good strong button cord, then coats the top and the bottom side of those stitches with clear nail polish. She also does that on all new garments' buttons, which helps them last a lot longer.
She learned all those years ago and still does. Save that good strong elastic from the waistband of men's under-shorts (so easy to remove) to use as replacement elastic for slacks and such. That elastic was - and still is - made to last. When Anna Mary and I grew up, elastic often had a label declaring it boil proof.
Think that over. Wow! Elastics today can't even take the dryers' heat for very long. Another of her tips we've used before but bears repeating: shoulder pads come in all shapes and sizes, some of them just right to lace two of them together, inserting a scrap of lace between them, which is very useful as pin cushions, even making a pretty and useful gift. Keep one on the dresser and another in the bathroom. You'll be surprised how often you will use that one. Nice hearing from you again Anna Mary. I think it's past time for this old world to stop and think about all of the waste. Our younger generation is already beginning to pay for it. The hurt is only going to get worse. I'm thinking about only one item right now - plastics - piling up on our beaches worldwide.
Oh don't let me get started. Love you all. Bye and God bless, Aunt Norie, P.O. Box 265, Tonganoxie 66086, firstname.lastname@example.com.
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Category Archives: Language Arts
Turtle Diary
Turtle Diary describes itself as a "learning playground." Teachers through 5th grade will find tons of interactive games, worksheets and so much more! Many of these would work great with your interactive whiteboard. You can search by grade level or … Continue reading
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New Poetry Sets by ReadWorks.org
We have highlighted this site before but they have recently released a collection of K-12 Poems and Questions Sets to inspire a love of poetry. Each poem is paired with a question set designed to help your students comprehend the … Continue reading
Posted in Common Core, Grades 6-8, Grades K-5, Reading, Teacher Tools
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60 Ways to Use Twitter in the Classroom by Category
Here is a quick list by category of different ways to use Twitter in your classroom with your students, other teachers, or parents by Jane Clare. 60 Ways to Use Twitter in the Classroom by Category
Fact Monster
Try out Fact Monster from Information Please – students can get homework help, find interesting facts, search the reference desk, and use the thesaurus and almanac to gather information for any project. They have thousands of subjects. FactMonster
Posted in Geography, Grades 6-8, Grades 9-12, Grades K-5, Language Arts, Math, Search skills, Social Studies
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App for Free Children's Books for Educators
This is an "All-You-Can-Read" ebook service for kids. Educators can sign up for a free account to use on school devices, but there is a monthly fee if parents wish to use it at home. There are a wide variety … Continue reading
"The Best…" websites
Larry Ferlazzo is a widely known teacher, author, and blogger who has developed a multitude of "Best of" websites. This page lists 100s of his lists for everything from Art or Music, Math or English, to holidays and search engines. … Continue reading
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Make your own informative, animated map or enjoy watching the maps made by others. You do not need an account to watch, but you do need an account to save your own. To create an account all you need is … Continue reading
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Six Virtual Field Trips to Give Lesson Plans a Boost by Allie Gross
Are you looking for a virtual field trip for your classroom? One or all of these may just fill the bill. Six Virtual Field Trips to Give Lesson Plans a Boost
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Grammar Bytes
Learning grammar is easy and fun on this site full of practice exercises, video lesson, presentations, and quizzes. Grammar Bytes
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Common Core Explorer
Looking for ways to integrate more technology into the Common Core standards? This site will offer lots of possibilities. Multiple web tools and apps are aligned to specific common core standards. Not all tools are free, but they have all … Continue reading
Posted in Common Core, Digital Learning, Digital Storytelling, Grades 6-8, Grades 9-12, Grades K-5, Interactives, ipads, Language Arts, Math, Reading, Science, Teacher Tools, Writing
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