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Randy & The Rainbows
View In iTunesTo preview a song, mouse over the title and click Play. Open iTunes to buy and download music.
Even if you don't know the group by name, if you're the tiniest bit familiar with doo wop you'll still probably recognize Randy & the Rainbows' hit single "Denise." A Top Ten hit, it's one of those feel-good songs that continue to turn up on compilations of the best music from the 1960s.
Randy & the Rainbows formed in the Queens section of New York City in 1962. The group included two pairs of siblings, brothers Sal Zero and Mike Zero and brothers Frank Safuto and Dominick "Randy" Safuto. Ken Arcipowski rounded out the quintet. The group evolved from the Dialtones, which in 1959 included the Safutos, Rosalie Calindo, and Eddie Scalla, the Safutos' cousin. After recording during the early '60s for Goldisc, the Safutos hooked up with Arcipowski and the Zeros in 1962 to become Randy & the Rainbows. Backed by the production team that also handled the Tokens, the group put out "Denise" in 1963.
As Randy & the Rainbows, the group never again repeated the success they found with "Denise." They changed names several times and continued to perform at different times as Madison Street, Triangle, and Them and Us. Over the years, the group has shared the stage with such artists as the Spinners, Little Anthony & the Imperials, Tony Orlando, Blood, Sweat & Tears, Freddie Roman, Jay Black, and Pat Cooper. They have also toured with the Beach Boys, Dionne Warwick, and the Four Seasons.
The group put out a new album in 2001. As of that year, the Randy & the Rainbows' lineup included original member Mike Zero, Vinny Carella, and Jimmy Bense.


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Zakir Naik, a medical doctor by training, is the founder of the "Islamic Research Foundation" (IRF ) based in Mumbai, India and is a popular Islamic preacher. His preaching of Islam focuses on the peaceful, noble and scientific nature of Islam. He is very popular among Muslims all over the world.
Faithfreedom.org received the following email as part of a chain message from M. Ali, an Indian Muslim, which exposes Zakir Naik's lies, fallacies, deceptions and greeds:

subset: commoncrawl


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For new questions please post at magento.stackexchange.com, the community-run support site for the Magento community. We will be providing updates on the new forum solution soon. For questions or concerns please email email@example.com.
You can find the attached SQL-script that drops all admin privileges tables, and creates them again.
You have to login into the Magento admin using login admin and password 123123, go to System -> Permissions pages and create/update additional users & roles after running the script.
In case of any problems delete the var/cache and var/session folders, run the script and try to login again.
Please make sure that you backup all your data first.
That got me into the admin which is great, but Now I see a new issue. I went to go look at my attributes. The attributes are coming up with blank entries. I think this is related to the store level association.
Hi jmayer,
What were your previous version and package type ? What did you upgrade to ? Could you please also run the following query:
select `eav_attribute_option_value`.* from `eav_attribute_option_value`inner join `eav_attribute_option` using (`option_id`)where `eav_attribute_option`.`attribute_id` = 'NNN';
Thank you.
Thanks Michael , You saved me today
Best regards L. Nunes


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Fall FashionShirt jacket is hot for men's fall fashionSubmitted by Randy Aldridge on Mon, 09/30/2013 - 6:14am.READ MORE:
Layering, cuffing and backpacks are trends for men this fall. Michael Vincent of Bloke Apparel in Wilmington has five important things that are a must for men's fall fashion.
Full story... » 5 fall fashion essentials for womenSubmitted by Ashley Jacobs on Fri, 09/27/2013 - 8:43am.READ MORE:
Kelly Oliver steps away from her boutique, Oliver, to share the 5 'must haves' for the fall season.
Full story... » |


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15-11-2011 Comments (0)
BiotechnologyNorth AmericaPharmaceuticalRegulation
The numbers of warning letters and drug recalls issued by and reported to the US Food and Drug Administration…
In order to access this content you need to be logged into the site and have an active subscription or trial subscription. Please login, take a free trial or subscribe in order to continue reading.
A trial subscription will give you access to the latest news on The Pharma Letter for 7 days, in order to evaluate the paid service.


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InspectAPedia® | Question? Just ask us! |
| |
Free Encyclopedia of Building & Environmental Inspection, Testing, Diagnosis, Repair |
InspectAPedia ® Home STRUCTURAL INSPECTIONS & DEFECTS ATTIC STAIRS BALUSTERS, STAIR & RAILING BASEMENT STAIRS BEST CONSTRUCTION PRACTICES GUIDE BUILDING SAFETY HAZARDS GUIDE CHECKLIST for STAIR INSPECTIONS CIRCULAR & CURVED STAIRS CODES for STAIRS & RAILINGS DECK & PORCH CONSTRUCTION EXTERIOR STAIRS FIRE STOPPING for STAIRWAYS GRASPABILITY of HANDRAILINGS GUARDRAILS on BALCONIES, DECKS, LANDINGS HANDRAILS & HANDRAILINGS LIGHTING OVER STAIRS PLATFORMS & LANDINGS, ENTRY & STAIR RAILING CODES & SPECIFICATIONS RAILINGS, DECK & PORCH RAILINGS, STAIRWAY RAMPS, ACCESS SAFETY HAZARDS & INSPECTIONS SLIP TRIP & FALL HAZARD LIST, STAIRS SLIPS, TRIPS & FALLS, EXTERIOR STAIRS SLIPPERY STAIRS, WALKS SNAG HAZARDS on STAIRWAYS STAIR FALL & TRIP HAZARDS STAIRS, RAILINGS, LANDINGS, RAMPS STAIR DIMENSIONS, WIDTH, HEIGHT STAIR RAILS, STAIR GUARDS STAIR RISE & RUN CALCULATIONS STAIR HEADROOM STAIR RISER SPECIFICATIONS STEP TREAD DIMENSIONS STAIR TREAD NOSE SPECIFICATIONS STAIR STRINGER DEFECTS STAIRS, DECK & PORCH CONSTRUCTION STAIRS & RAILINGS CHECKLIST WINDER or ANGLED STAIRS More Information |
Stairway headroom & width codes & requirements: This document provides building code specifications, sketches, photographs, and examples of the stair passage width & stair overhead clearance or head room needed for indoor or outdoor stairs. How much space is needed over steps or stairs, and exactly where should those measurements be taken? Green links show where you are. © Copyright 2015 InspectApedia.com, All Rights Reserved. Stairway Height, Width, Headroom RequirementsStairway overall height, width, and headroom requirements & codes are detailed here. Our page top photo, courtesy Galow Homes and Eric Galow, shows where headroom clearance should be measured at a stairwell: stair overhead clearance is the vertical distance measured between the outer edge of the stair tread surface (close to the stair tread rounded nosing), and the under-side of the ceiling above. Specifications for Stairway Overhead Clearance: Headroom
Re-stating this for clarity: Stair way headroom should be 12' or less between floors - or restated, the total rise for a set of steps between floors should be less than or equal to twelve feet. This means landings could be required if the total rise height of a stairway is more than 12 ft. Sketch at left provided courtesy Carson Dunlop Associates. Model & Example California Building Code Specifications for Stairway Headroom Requirements Continue reading at STAIR PLATFORMS & LANDINGS, ENTRY or select a topic from the More Reading links shown below. Suggested citation for this web pageSTAIR HEADROOM at InspectApedia.com - online encyclopedia of building & environmental inspection, testing, diagnosis, repair, & problem prevention advice. More ReadingGreen link shows where you are in this article series.
Frequently Asked Questions (FAQs)No FAQs have been posted for this page. Try the search box below or CONTACT US by email if you cannot find the answer you need at InspectApedia. ... Ask a Question or Search InspectApediaQuestions & answers or comments about stair codes & requirements for headroom over steps or stairways. Use the "Click to Show or Hide FAQs" link just above to see recently-posted questions, comments, replies, try the search box just below, or if you prefer, post a question or comment in the Comments box below and we will respond promptly. Search the InspectApedia website HTML Comment Box is loading comments...
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Dictionarypas•tisPronunciation: (pa-stēs'; Fr. pas-tēs'), Strict Standards: Non-static method FenSites::linkTo() should not be called statically in /site/html/dictionary/pastis.html on line 73 [key] —n. a yellowish, anise-based liqueur originally made in Marseilles and similar to absinthe but containing no wormwood. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease.
See also:


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crime - Page 8
Murder Spreads Through a City Like an Infection in the Body
[UPDATE] New Hampshire Couple on Run After Abusing 3 Year Old Boy, Found in Florida
The Plaistow, NH couple wanted by police and accused of child abuse have been found. Police have been looking for Roland Dow and Jessica Linscott for 2 weeks since Linscott's 3-year-old son, James, was taken to a hospital with serious injuries.
Wedding Turns into a Brawl and Leads to 2 Arrests in Herman, ME
Your wedding. What is supposed to be a memory of a lifetime turned into memories the bride and groom would like to forget. Friday night (Nov. 23) brawls broke out during a wedding reception in Herman, ME. That led to the arrest of two of the guests.
[UPDATE] 4 More 'John' Names Released in Kennebunk Zumba Prostitution Scandal
More names have been released in the Kennebunk prostitution ring involving Alexis Wright, a Zumba instructor in Kennebunk. Today 4 more names were revealed by the Kennebunk Police.
Cushing Man Jailed for Whacking Wife with His Genitals
Once in a while a story comes along that makes you shake your head. Maybe I should rephrase that. It makes you question peoples' actions. One such story comes out of a neighboring town, Warren, and it's just bizarre.....
[UPDATE] Waterville Police Make Arrest of Couple Involved in Purse Snatching at Wal-Mart
From the Waterville PD facebook page:
CASE CLOSED: This afternoon, Officer Dennis Picard charged Heather Folsom, 23 and Brandon Brasher, 24 of Pittsfield for one count (each) of Class C Felony Theft by Unauthorized Taking or Transfer in the Walmart purse theft case featured on this page yesterday. Folsom and Brasher will appear in Kennebec County Superior Court on January 29, 2013 to answer this criminal charge. Thank-you to everyone who shared this information and to the several individuals who called us with tips.
Rappers Rob Studio, Leave Song Behind as Evidence
Two men entered a recording studio as rappers and left as robbers. But its something they left behind that might do the thieves in.
Watch these Thieves on Motorcycles 'Smash and Grab' a Jewelry Store in London Mall
In a scene that looks like it was taken straight out of an action movie, six black-clad men recently rode into a north London mall on motorcycles and helped themselves to a fortune in jewelry. Where's James Bond when you need him?
Drug Smugglers Try To Cross Border Fence With Ramps… And Get Stuck
Drug smugglers try to get across the border fence in a multitude of different ways, ranging from digging tunnels to climbing the wall. But a particularly industrious group tried to do it with a little engineering... and failed miserably.


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Sheer genius.'C Chic 3582' Full Support Underwire Bra
- Item #267418
Details & Care
- Logo mesh patterns a beautifully designed underwire bra with three-part cups that are sheer on top but lightly lined at the sides and underneath for exceptional support with a natural shape.
'C Chic' Bikini
- Item #279418
Details & Care
- Logo-mesh insets at the hips lend just the right amount of patterning to a sophisticated style.


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Apple rumored to unveil new MacBook Airs in June or July
Digitimes reports that Apple will introduce new MacBook Airs this June or July. The site states that Apple will introduce new 11.6-inch and 13.3-inch MacBook Air models that will include Thunderbolt ports and Intel's Sandy Bridge processors.
This latest Digitimes report substantiates rumors from CNET of a June Sandy Bridge MacBook Air update that first surfaced as far back as February. In late April, a Concord Securities analyst stated that Apple is set to begin mass production on new models of the MacBook Air in May, which would coincide with a June launch.
Since the MacBook Air was revamped last October, it's quickly become one of Apple's hottest-selling laptops, and one would expect that Apple would want to have new models on the market to entice buyers during the back-to-school buying season, which typically begins in late June/early July.
Software Updates
more updates- Apple Remote Desktop updated with Yosemite support
- OS X Yosemite 10.10.2, iOS 8.1.3 updates now available
- Sports Illustrated 120 SPORTS channel comes to Apple TV
- Logic Pro X update brings AirDrop support, new effects, tools, and more
- Parallels Access 2.5 released, adds file manager, computer-to-computer remote access
- The Google Translate iOS app is about to get a lot smarter


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VIDEO: a chat with James Blunt
The British singer-songwriter is all set to enthral his Dubai audience with a number of hits
February 26, 2015 5:30 by fpilkingtonRegister for our free newsletter
Abu Dhabi's Etisalat jumps on Q4 results, dividend
UAE court sentences six Iranians to life in jail over British businessman's kidnap
MIDEAST STOCKS-Gulf markets may rise after oil's surge
Funds increasingly bullish on Saudi Arabian equities
Gold steadies as US rate hike timing expectations ease
Gold hits 7-week low, then pares losses after Yellen testimony
Power company Taqa Morocco's full-year net profit doubles
Gulf economies have failed to diversify, Qatar c.banker says
Oil slips towards $58 on ample supply, stock build
Qatar's Woqod tumbles after 2014 earnings, dividend cut
Kamal Hassan advises all starting Entrepreneurs to take a roller coaster ride, because that's what entrepreneurship will be like.
November 6, 2012 3:00 by Muhammad Aldalou
Recently, the results of an international study by Booz & Company caught Kipp's eye. It was a study that observed the most innovative companies around the world, ranking them on the basis of business sophistication and innovation with their ideas, culture and output. It caught our eye because the only representation on that list that emerged from the GCC was Saudi Arabia's SABIC.
As Kipp sat down with Kamal Hassan, President & CEO of Innovation 360 Institute (otherwise referred to as i360), we discussed just exactly how innovative the UAE is in terms of its SME landscape, what makes a good Entrepreneur and the importance of both education and passion when climbing the ladder of innovation.
Innovation 360 is a global innovation management consultancy that helps companies of all sizes and government organizations bridge the gap between innovation strategy and execution.
One of the key topics that Kipp was interested in wasn't restricted to the mere empowerment of women in the workplace – as it has been a hot topic in the country over the past few years – but the amount of businesswomen and female entrepreneurs. Kipp said that, judging by what we constantly hear and see, there is a lack of them.
"I completely disagree with that," says Hassan. "Yes there is an imbalance in the population, which translates to the work place but whenever we hold an event or business seminar, over 70 percent of the attendees are female entrepreneurs."
He continues to express his optimism about this matter and that even though there is a lack of women entrepreneurs in the 'hard-core' technology segment, there are plenty on the creative side.
Diversity, naturally, has always been a word that is closely associated with the UAE's work force. "We have a very diverse culture, which brings a lot of opportunities for innovation. Here we can have a Middle Eastern Arab, a European and an Asian in one company and that creates the benefit similar to areas like Silicon Valley which is rare to find except in the UAE," Hassan says.
Some of the remaining challenges, according to him, are related to residency, immigration and start-up costs. "Of course, over the last 5 years, many free zones in the UAE have reduced the costs for start-ups dramatically. At one point it would have cost up to AED 50,000 where now it can be as low as AED 10,000."
"On the part of the government, there are still some changes to be made in terms of residency or immigration because if an expatriate can call the country home then they're likely to produce and create more."
While Hassan briefly touched on the issue of a bankruptcy law, or lack thereof, in the UAE, Kipp wondered how far changes made by the government will progress in the next few years.
"I've moved here five years ago and since then, a lot has changed. There is a strong push to change policies. The leaders are listening and I think they're working very hard to push and promote the culture of innovation. The changes might be slower than we would want because innovators want things to happen quickly but there are definitely changes."
The British singer-songwriter is all set to enthral his Dubai audience with a number of hits
February 26, 2015 5:30 by fpilkingtonKippreport has an in-depth look at Oppo's new R5
February 3, 2015 5:41 by fpilkingtonFrom a CD and DVD store to a lifestyle destination
December 15, 2014 4:56 by fpilkingtonNervous about your first job interview? Here's some feedback from Dubai's latest recruits.
November 3, 2014 6:35 by fpilkingtonThe British singer-songwriter is all set to enthral his Dubai audience with a number of hits
February 26, 2015 5:30 by fpilkingtonKippreport has an in-depth look at Oppo's new R5
February 3, 2015 5:41 by fpilkingtonWhat's next... an app that will be able to take your exam for you?
January 4, 2015 4:00 by fpilkingtonThe video, taken in The Dubai Mall, has already received more than 1 million views
December 18, 2014 9:05 by fpilkingtonFrom a CD and DVD store to a lifestyle destination
December 15, 2014 4:56 by fpilkingtonFord Middle East continues the unveiling of its 2015 Ford Mustang at the Burj Khalifa with a live action event
December 4, 2014 8:33 by fpilkingtonFord Middle East launched the 2015 Ford Mustang last week, but you will never guess how they did it...
November 24, 2014 10:44 by fpilkingtonREDUNDANCY AND RESISTANCE: Faxing frustrations in a digital age
November 6 2012
UK & UAE plan defence partnership
November 6 2012


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READER SUBMITTED: Jay Rowe's "Smooth Jazz For Scholars" Concert ... Hartford Courant The show on April 19 will feature guitarists Chieli Minucci and Nick Colionne and saxophonists Marion Meadows and Nelson Rangell. The back up band for both nights will be guitarist Rohn Lawrence (only on April 18); Trever Somerville on Drums; Dave ... |
Nick Colionne to Heat Up Montrose Room for Valentine's Chicago Tribune Nick Colionne, American Smooth Jazz Awards's 2010's Guitarist of the Year and Entertainer of the Year, will perform a sultry Valentine's show at Montrose Room on Saturday, February 15 with special guest, Grace Kelly (jazz sax, vocalist). Showtime is 8 pm ... |
GRandJazzFest welcomes young musicians for jazz jam session during free ... MLive.com ... Anthony C. Burrell on saxophone, Olin Clark on guitar, Kim Vi on keyboards, Aidan Cafferty on bass and Nicholas Bracewell on drums. The second Grand Rapids Jazz Festival, still an entirely free event, adds a second day of music, promising entertainment ... and more » |
Night After Night San Antonio Express Nick Colionne, Jonathan Fritzen at Wonderland of the Americas mall (7 p.m.). The 19th annual Balcones Heights Jazz Festival opened last week with sax man Steve Cole and a big crowd. This week's edition will feature Chicago-based guitarist and singer ... |
Jazz guitarist to play African-American Festival Toledo Free Press Nick Colionne may be as well-known for his fine fretwork on guitar as he is for that dapper appearance. After picking up the instrument at age 9, it wasn't long before the guitarist created a personal style, complete with mascara. Nick Colionne. "I always played ... |
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Pop Culture
Hollywood Now: Emmy Rossum & Mila KunisBy Gerri Miller
Updates on celebrities in interfaith relationships including Mila Kunis, Emmy Rossum, Ian Ziering and more
Go To Pop Culture
Tag Archives: ideasNew Ideas about Jewish NewcomersI've been out and about lately (Diversity Shabbat at Temple Chai in Long Grove and the PJ Library Conference in Baltimore) hearing some things that are making me think. I am a philosophizing kind of gal, so I love to hear new nuggets that stop me and give me pause. These are random comments I have heard which I share with you. I look forward to your thoughts about them.


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Management Information Systems for the Information AgeThis text provides a clearly focused overview of information systems, and is best suited to an MIS course where students have a lot of hands-on, problem-solving projects. It also examines the themes of electronic commerce and the way in which organizations use information systems. |
What people are saying - Write a review
Review: Management Information Systems for the Information Age
User Review - Jalal - Goodreadstest Read full review
Review: Management Information Systems for the Information Age
User Review - Joecolelife - GoodreadsThis book is an asset. Even after finishing my course, I haven't sold it back. I know I am going to use it for reference later on. Easy language, various examples and online study guide. All are helpful in becoming an excellent Operations Manager. Read full review
Want It | 13 |
Redefining Business Operations Through | 19 |
Copyright | |
81 other sections not shown
Common terms and phrases
artificial intelligence bank business processes cable Chapter client client/server communications media competitive intelligence components connect consider cost create customers data mining data warehouse database DBMS decision support systems e-cash electronic commerce emerging technologies employees entity classes environment example expert system Figure firm GDSS genetic algorithm global goals groupware identify implementation important INDUSTRY PERSPECTIVE information partnership information systems information technology interface internal Internet intranet knowledge workers logical manufacturing mation meeting ment million multimedia application neural network nization OHP strategy OLAP orga outsourcing percent perform primary key problem require selfsourcing server share specific speed step supports this text systems development systems plan tasks telecommuting tion tomers transaction users virtual organization virtual reality wireless


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Hardware news tagged Durango
Monday, June 10, 2013
Microsoft Announces Xbox One Pricing, Availability Timeframe.
[10:50 am]
Microsoft Xbox One to Ship This November in 21 Countries
Thursday, June 6, 2013
Microsoft Xbox One Will Allow to Share, Resell Games, But Only Under Microsoft Supervision.
[10:40 pm]
Microsoft to Provide Sophisticated Game Sharing Capabilities, But Will Limit Usage of Old Games
Microsoft Xbox One Will Require Online Checks Every 24 Hours.
[10:03 pm]
Microsoft Xbox One Will Perform Licensing Checks Every Day
Monday, June 3, 2013
Next-Generation Game Consoles to Cost $349 - $399 – Analyst.
[9:51 pm]
Sony PlayStation 4 to Cost Less Than Xbox One
Wednesday, May 22, 2013
Microsoft Not Worried About Xbox One's Lack of Backwards Compatibility, Vows Big Xbox 360 Announcement at E3.
[7:09 pm]
Microsoft Believes Xbox One Will Not Require Games of Xbox 360
Tuesday, May 21, 2013
Microsoft Xbox One to Run Two Operating Systems at Once.
[9:03 pm]
To Provide the Best Experience, Xbox One Will Rely on Several Operating Systems
Microsoft Xbox One Will Not Require "Always On" Connection, But Will Need the Internet for Nearly Everything.
[8:59 pm]
Microsoft Xbox One Will Need Internet Connection for Majority of Things
Microsoft Xbox One Will Not Be Backwards Compatible with Xbox 360 Games.
[7:51 pm]
Microsoft Drops Backwards Compatibility for Xbox One
Microsoft Unveils Xbox One: The One and Only Machine One Needs in the Living Room.
[6:44 pm]
Microsoft Reveals Its New Vision for Game Consoles with Xbox One System


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Dr. Cornelia Gallo specializes in child psychiatry in Westport, Connecticut.
Dr. Cornelia Gallo has been compared 80 times. Details of Dr. Gallo's 23 years experience as an MD and education at Georgetown University are available on your free doctor report.
Primary Location for Dr. Gallo
19 Compo Rd S
Westport, CT 06880
Ratings and Reviews for Dr. Cornelia Gallo
Board Certification, Specialty and Expertise
Dr. Cornelia Gallo has been identified as specializing in Child Psychiatry.
Dr. Gallo attended medical school at Georgetown University School of Medicine and graduated in 1992 having 23 years experience.
While there is no proven correlation between the quality of one's educational institution and the quality of one's professional competence, it is often an indicator. Medical schools have various levels of selectivity (some are harder to get into than others), and both the quality of their clinical training and level of research are measured. Additional medical training in both residency and fellowships and the facilities they are conducted at also provide a history of the doctors' level of training and experience.
Patients may also know Dr. Cornelia Gallo MD as:
Trending Providers
Psychiatry, Child Psychiatry
1 Turkey Hill Rd S, Westport, CT 06880
Child Psychiatry1 Turkey Hill Rd S, Westport, CT 06880
Psychiatry, Child Psychiatry225 Main St, Suite L1 Westport, CT 06880
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Psychiatry, Child PsychiatryRoger Ayres, MD, 177 Post Rd W, Suite 5 Westport, CT 06880
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Yale-New Haven Hospital
New Haven, Connecticut -
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Child Psychiatry34 Imperial Ave, Westport, CT 06880
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Articles by Bo Wagner
Thoughts On The Tragedy In Connecticut
All of our thoughts are, of course, much occupied with the senseless murder of so many children in an elementary school in Connecticut this past week. A madman, one with not so much as a... READ MORE
What we can learn from Bugle the Wonder Dog
It was a late night several years ago, and my family and I were on the way to our little home in the country. As we traveled down our moonlit road, I saw something lying on the center line, not ... READ MORE
"And God said, 'Go chase cows'"
Being both hyper and a poor judge of how much activity I can fit into a given day, the one thing I can always count on is being extremely busy. Such was the case on a Wednesday just a couple of ... READ MORE
Column: God told me to 'Go Chase Cows'
Being both hyper and a poor judge of how much activity I can fit into a given day, the one thing I can always count on is being extremely busy. READ MORE
Column: The Two Keys To Turning Hurt Into Happiness
Oftentimes in life things do not go as we would like. People are people, meaning that they come complete with tempers, likes and dislikes, and flaws. In addition to that life provides ample opportunities for mistakes, misunderstandings, and overreactions. READ MORE
A right between the eyes truth!
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I am writing this a day after it happened, and am both smiling at it, and also a bit fearful knowing how serious of a matter it always is. My phone rang yesterday, and the caller on the other end was Sharon, a precious lady from our church. She said "Preacher, I had to call you right away READ MORE
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SARA CHAMPION HALL KINGS MOUNTAIN – Sara Champion Hall, 83, resident of Kings Mountain, went to be with the Lord on Feb. 27, 2015, at Cleveland... -
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RACHEL HARRIS BESSEMER CITY – Mrs. Rachel Bess Harris, 78, of 141 Miles Bess Road, passed away on Saturday, Feb. 28, 2015, at Peak Resources in... -
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SHERYL LITTLE Ms. Sheryl Denise Dawkins Little, 50, of 837 Logan St., Shelby, NC, died Saturday, Feb. 28, 2015, at Wendover Hospice in Shelby. The... -
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I'm a newbie to the forums and PRS guitars in general, although I'm now a convert!
I recently decided to get rid of my Gibson Firebird that I bought purely because it looked cool, but I just couldn't get on with the tone, l didn't want to go down the route of swapping out pickups, so put it up for sale / trade. I'd seen a PRS Studio for sale on a guitar forum I use and was intrigued, lots of reviews, YouTube videos later I was hooked!
As luck would have it, I found a 10 top quilt studio less than 30 miles away on eBay, I contacted the guy and he was keen to part ex with my Firebird . The guitar looked and played beautifully, so I gave him my guitar, some cash and drove off before he could change his mind
I was and still am, blown away by the guitar, the quality is outstanding, the playability is better than any of the other 'high end' guitars I own, or have even played. I then made he mistake of reading up on DGT's! I was in the process of selling off my pro camera gear and just found something to reinvest the cash in
i found a 10 top DGT for sale, brand new but on sale, I spoke to the shop, got them to send me some photos and put a deposit on it! I collected that Saturday, what a beauty, it sounds and plays like a Les Paul should do, but doesn't quite manage!
The guitars in question:
The only worry is, gigging these two, so I've started thinking about trading another guitar for a Mira, the question to you guys, how would a Mira fit tonally between these two?
Apologies for the long post


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Match % Unknown Join to find out!Books: The Beatles Anthology, Paul McCartney: Many Years From Now; John, Paul, George, Ringo, and Me: The Real Beatles Story; The Mighty Book of Boosh, Romancero ... The Beatles, Paul McCartney, British accents, Beatle boots, bacon, Beatles wigs, British Harper's Bazaar, NME, Español, Français,
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text: University of Newcastle Whether you want to broaden your mind, advance your career, increase your NEWCASTLE CAMPUS – CALLAGHAN knowledge, travel the globe or change the world, the University of Newcastle CRICOS provider number 00109J can provide you with the opportunity and real-life skills to do it. postal enquiries in person OPEN DAYS IN 2011 Enquiry Centre Any Student Hub Newcastle campus – Callaghan Sat 27 August 2011 The University of Newcastle Student Services Centre or Central Coast campus – Ourimbah Sat 20 August 2011 Callaghan NSW 2308 Shortland Union Building Port Macquarie campus Thur 1 September 2011 The University of Newcastle For further information call (02) 4921 5000. tel: (02) 4921 5000 University Drive, Callaghan NSW fax: (02) 4985 4200 email: firstname.lastname@example.com A Student Hub is also located ADMISSION REQUIREMENTS website: www.newcastle.edu.au/askuon at University House in the For admission to a postgraduate coursework program you would normally be Newcastle city precinct. expected to have a Bachelor degree or three-year diploma from a recognised tertiary institution in an appropriate discipline. You may also need relevant, CENTRAL COAST CAMPUS – OURIMBAH professional work experience for entry to some programs. For some programs, CRICOS provider number 00109J entry is available on the basis of relevant, professional work experience alone. You can obtain information about the entry requirements for each program postal enquiries in person from the University website at http://search.newcastle.edu.au/program/ Student Hub Student Hub The University of Newcastle The University of Newcastle Overseas qualifications and English proficiency PO Box 127 Chittaway Road, Ourimbah NSW If you hold overseas qualifications from countries where English is not the Ourimbah NSW 2258 standard language of instruction you must provide evidence of English language proficiency. Refer to the English language proficiency table at tel: (02) 4348 4000 www.uac.edu.au/postgraduate/faq/elp.shtml for information about tests and fax: (02) 4348 4035 qualifications accepted by the University as proof of proficiency in English. email: firstname.lastname@example.com website: www.newcastle.edu.au/askuon SPECIAL/ADDITIONAL REQUIREMENTS PORT MACQUARIE CAMPUS You may have to provide specific documentation as part of the CRICOS provider number 00109J application process. Check UAC's postgraduate website at www.uac.edu.au/postgraduate/course-search/ to see whether special For enquiries regarding study at Port Macquarie call the Enquiry Centre on requirements apply. (02) 4921 5000. How do you obtain detailed information about the additional requirements? SYDNEY CAMPUS 1 Download from the relevant Faculty website, as detailed at CRICOS provider number 00109J www.uac.edu.au/postgraduate or For enquiries regarding study at Sydney call the Enquiry Centre on 2 Collect from any of our Student Hubs – see above for contact details (02) 4921 5000. and location of campuses. Where do you submit your additional material? You must send or deliver your additional material directly to the University. Selecting a university degree program marks the start of an exciting period of your life. The University of Newcastle produces self-confident well-equipped 'job- When you submit your curriculum vitae (CV) or resume or any other ready' graduates. Our postgraduate programs are offered through five faculties: documentation required, you must include a covering letter, stating your full name, daytime telephone number, UAC application number and the n Business and Law program/s to which you are applying. You must provide your documentation n Education and Arts directly to the University at the same time that you submit your application n Engineering and Built Environment to UAC. n Health n Science and Information Technology. post to: email to: Admissions Officer firstname.lastname@example.com Our degrees focus on both academic and professional training. You will be Student Services Centre taught in a variety of methods and can gain real-life experience from field The University of Newcastle excursions and long-term work placements. Callaghan NSW 2308 We have a student population of more than 30,000, including some 4,000 deliver to: international students from more than 80 countries. Our campuses at Admissions Officer or Student Hub Newcastle, the Central Coast and Port Macquarie are all set in bushland Student Services Centre Opposite Café Central settings and are close to some of Australia's most beautiful beaches: The University of Newcastle The University of Newcastle n Our Newcastle campus at Callaghan, 12 kilometres from the centre of University Drive, Callaghan NSW Chittaway Road, Ourimbah NSW Newcastle, is located on a 140 hectare bushland site and caters to approximately 24,000 students and staff. When do you have to submit your additional material? n The Central Coast campus at Ourimbah is located halfway between Submit your material by the date specified in the relevant course description Sydney and Newcastle. It is an innovative educational precinct, which at www.uac.edu.au/postgraduate/course-search/ includes the University, TAFE NSW – Hunter Institute, and the Central Coast Community College. TYPES OF PROGRAMS AVAILABLE n The University also has a significant presence in Newcastle's CBD. The Conservatorium, The University of Newcastle Legal Centre and Newcastle The University offers a wide range of coursework programs at postgraduate Business School are all located near Civic Park in the centre of Newcastle. level through UAC – Masters, Graduate diplomas and Graduate certificates. n On the mid-North Coast of NSW, our Port Macquarie campus is shared by Visit www.uac.edu.au/postgraduate/ for details. the University and TAFE NSW – North Coast Institute. Postgraduate research and honours programs are available through direct n Our Sydney campus offers easy access to the conveniences of Sydney's application to the University. The University also offers a range of online CBD and surrounding areas. postgraduate coursework programs through GradSchool. For more The University sits in the top 10 universities in Australia in terms of our information visit www.gradschool.com.au/ research. We undertake research that makes an impact on the world with There are limited postgraduate coursework places available as strengths in health, energy and environment, and science and engineering. Commonwealth-supported places. These places are only available in 18 Master of Teaching programs, the Master of Architecture, the Master of University of Newcastle Scholarships Clinical Psychology, the Graduate Diploma in Midwifery, the Master of Limited scholarships are offered by the University for postgraduate students Midwifery Studies and the Master of Mental Health Nursing programs. in specific areas of study. Information and application forms for all scholarships are available at http://webapps.newcastle.edu.au/scholarships/ IMPORTANT DATES or call (02) 4921 5000. Application closing dates Youth and student allowances For application closing dates, including final closing dates for each course, visit Support schemes are available from the Australian Government to help UAC's postgraduate website at www.uac.edu.au/postgraduate/course-search/ you continue your studies. Specific criteria must be met to become eligible. Contact Centrelink on 13 24 90 for more information or visit the Centrelink Enrolment/intake dates website at www.centrelink.gov.au Your final enrolment date will be indicated in your enrolment package. DIRECT APPLICATIONS Intake 1 Trimester 1 Mon 30 January–Fri 27 April 2012 Recess (Stuvac) Mon 30 April–Wed 2 May 2012 Only postgraduate coursework programs are offered through UAC, as listed Examinations Thur 3–Fri 11 May 2012 on UAC's postgraduate website at www.uac.edu.au/postgraduate/. Contact Intake 2 Semester 1 Mon 27 February–Fri 1 June 2012 the University directly if the program you are interested in is not listed on the Recess Fri 6–13 April 2012 UAC's postgraduate website. Examinations Sat 9–Fri 22 June 2012 Postgraduate research programs are available through direct application to Intake 3 Early entry for Trimester 2 (see dates below) the University. For information about all postgraduate programs offered by the University visit www.newcastle.edu.au/campaigns/postgrad/ Intake 4 Trimester 2 Mon 21 May–Fri 10 August 2012 Recess (Stuvac) Mon 13–Wed 15 August 2012 It is important that you distinguish between those programs for which you can Examinations Thur 16–Fri 24 August 2012 apply through UAC and those for which you must apply directly to the University. Intake 5 Semester 2 Mon 23 July–Fri 2 November 2012 Recess Mon 24 September–5 October 2012 INTERNATIONAL FEE-PAYING APPLICANTS Examinations Mon 5–Fri 23 November 2012 International fee-paying applicants must apply directly to the University. For Intake 6 Trimester 3 Mon 3 September–Fri 23 November 2012 further information visit the University's International Admissions Services Recess (Stuvac) Mon 26–Wed 28 November 2012 website at www.international.newcastle.edu.au Examinations Thur 29 November–Fri 7 December 2012 Contact details ENROLMENT The International Admissions Officer The University of Newcastle Callaghan NSW 2308 Australia Acceptance of offer tel: +61 2 4921 6595 If you are offered a place in a postgraduate program you will receive an offer email: firstname.lastname@example.com notification from UAC. To accept your offer you should then visit the UAC acceptance page on the University's website at www.newcastle.edu.au/uac and follow the instructions. STUDENT SERVICES AND FACILITIES Students can take advantage of a range of services and facilities such as: Advanced standing/academic credit n student accommodation (on- and off-campus) If you have already successfully undertaken relevant study at another higher n careers and student employment education institution you may be granted credit on enrolment in a program. n chaplaincy You need to submit a credit application with correctly verified copies of n childcare appropriate documentation such as academic transcripts and course n counselling content descriptions. Information about applying for credit can be found n disability support at www.newcastle.edu.au/service/credit-transfer/ n student exchange programs n health Deferment n library and computer services Deferment of postgraduate offers may be available for up to one year. n learning support Contact the University for further information. n sports and recreation facilities n student organisations. FEES AND CHARGES Transport Study costs are dependent on whether the student is enrolled as a There are buses to the Newcastle campus (Callaghan) and the City Precinct Commonwealth-supported student (CSP) or a fee-paying student. (including The Conservatorium and University House) from most Newcastle suburbs and surrounding areas. Private bus services run from the Central Most postgraduate students are full fee-paying and are required to pay a Coast campus (Ourimbah) to Gosford and Wyong. tuition fee per unit studied, charged on a semester/trimester basis. Refer to www.uac.edu.au/postgraduate/ for an estimate of costs. The fee is Regular trains run from University Station Warabrook. Larger stations at indicative only and varies dependent on selection of courses within the Broadmeadow, Hamilton and Newcastle have connecting trains to Sydney study program. Fees are subject to change on an annual basis. and the Central Coast. The Ourimbah station, a five-minute walk from the Central Coast campus, has frequent services to Sydney and Newcastle. Eligible, domestic fee-paying students enrolled in a postgraduate coursework course may have access to the Australian Government's FEE-HELP Scheme. Car parking is available at both campuses. Parking costs $4 a day at Further information can be found at www.uac.edu.au/postgraduate/ Newcastle. Parking restrictions apply on the Central Coast campus. Our Sydney campus has all the conveniences of Sydney buses and trains FINANCIAL ASSISTANCE within close distance. Check www.goingtouni.gov.au for information on Australian Government financial assistance available to postgraduate students. FURTHER INFORMATION University of Newcastle Loans For information about the full range of postgraduate Our Student Loans Scheme provides interest-free emergency loans on a programs offered by the University of Newcastle short-term basis to students who demonstrate genuine need and cannot (including detailed course information, availability and continue their study without financial assistance. Loans may be approved entry requirements) visit our website at for rent, bond, living expenses and textbooks. Loans are not available for the payment of fees or to purchase capital items such as computers or cars. Loan www.newcastle.edu.au/campaigns/postgrad/ applications are treated confidentially and assessed on an individual basis. For further information email firstname.lastname@example.com or call the Callaghan campus on (02) 4921 6466 or the Ourimbah campus on (02) 4348 4177. 19


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Chip Sales Constrained: Second-Half View
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The U.S. is the largest consumer electronics market. In 2009, 20% of the global consumer electronics revenue came from purchases in the U.S./Canada, followed by Western Europe, with 19%. Weak consumer demand in 2010 will translate to weak chip sales.
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Are you ready to? 1. Eat Better 2. Eat Raw 3. Get rid of your bulky blender and Cuisinart 4. Take your cooking and baking to the next level of convenience! 5. Eat with more horsepower! Then you may be ready to take on the VITAMIX challenge. Finally, a resolution you can keep! 4 Day Roadshow starting Thursday the 17th through Sunday the 20th from 11am til 7pm each day! |
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Maria Sharapova reportedly contracted a stomach virus after losing the Olympic final to Serena Williams and had an ultrasound performed upon her return to States to rule out a common cause of stomach trouble — "[I had an ultrasound] because of the pain I was having," Sharapova said after defeating Melinda Czink 6-2, 6-2 in the first round of the U.S. Open. "It was really weird. They told me I was fine, not pregnant. I'm like, 'Can I get my money back?'" Close call Maria. -TO
Maria Sharapova's ultrasound confirmed she wasn't pregnant


text:
6th Annual
April 21-22, 2015
This conference features medicinal chemistry-focused case studies of small molecule and macrocyclic drug candidates progressing in pre-clinical and clinical development. In addition to presentations highlighting the well-known kinase inhibitors progressing in the pipeline, drug leads directed against 'newer' kinases and non-kinase targets will be a part of the meeting. Connections between inflammation and other disease processes will also be explored. Join fellow drug discovery scientists for this day-and-a-half meeting that is in the first half of CHI's larger Drug Discovery Chemistry event.
Speakers were great and presented valuable data. Comprehensive conference andoverview of most current inflammation targets and therapies. Tina T., Associate Scientist, Biogen Idec
Speakers were great and presented valuable data. Comprehensive conference andoverview of most current inflammation targets and therapies.
Day 1 | Day 2 | Download Brochure | Speaker Biographies | Register
Tuesday, April 21
7:00 am Registration and Morning Coffee
8:00 Chairperson's Opening Remarks
Seng-Lai "Thomas" Tan, Ph.D., Director and Head, Cellular and Translational Immunology, EMD Serono Research and Development Institute, Inc.
8:10 The Discovery of APD334, a Selective S1P1 Functional Antagonist
Robert M. Jones, Ph.D., Associate Vice President, Medicinal Chemistry, Arena Pharmaceuticals
Sequestration of T-lymphocytes into lymph nodes and other secondary lymphoid tissues by S1P1 receptor functional antagonists has been of therapeutic interest for the treatment of a variety of autoimmune diseases. Second generation molecules with reduced side effect profiles have become highly sought after. Herein, we will highlight the design and synthesis of a second generation series of orally efficacious small molecule S1P1 functional antagonists that culminated in the identification of the clinical candidate, APD334.
8:40 New Targets Emerging from Genetics: Time to Look Back, Move Forward with Phosphatases? (PTPN22)
Nunzio Bottini, M.D., Ph.D., Associate Professor, Division of Cell Biology, La Jolla Institute for Allergy and Immunology
Tyrosine phosphatases are considered interesting targets, but are rarely pursued because they are notoriously difficult to drug. Recent human genetic studies have shown that tyrosine phosphatases are encoded by several disease risk genes and have reignited the interest in these enzymes as possible targets for personalized medicine. Here we will describe the case of PTPN22, a phosphatase encoded by a major arthritis gene and discuss proposed strategies to drug tyrosine phosphatases, avoiding known pitfalls.
9:10 Sponsored Presentation (Opportunity Available)
9:40 Coffee Break
10:05 Targeting Interferon Regulatory Factor 5 (IRF5) with Cell Penetrating Peptides: Structure-Based Design and Characterization of Novel Tools for Direct Assessment of IRF5 Function
Interferon regulatory factor 5 (IRF5) is a critical downstream effector of Toll-like receptor (TLR)-dependent signaling. We report the identification and evaluation of six cell-penetrating peptides (CPPs) designed to disrupt protein-protein interactions considered critical to IRF5 dimerization and/or function. Biochemical studies showed these peptides directly bind IRF5. IRF5 CPPs blocked pro-inflammatory cytokine production in human peripheral blood mononuclear cells stimulated with TLR 7/8 ligand, and IFNa production from plasmacytoid dendritic cells stimulated with TLR9 ligand. Thus, our IRF5 CPPs represent promising tools to probe IRF5 function in vitro and for further development of novel therapeutics against TLR7/8/9-dependent autoimmune diseases.
10:35 Inhibitors for Inflammatory Bowel Disease
Kamal Puri, Ph.D., Associate Director, Research, Gilead Sciences, Inc.
11:05 Novel Small Molecule Immunomodulators that Target Toll-Like Receptors
Hang Hubert Yin, Ph.D., Associate Professor, Chemistry and Biochemistry & BioFrontiers Institute, University of Colorado
We have developed a novel in silico screening technology, which we applied to target the TLR4/MD-2 complex aiming to identify novel pain management therapy. Experimental results demonstrated that the identified compounds selectively block TLR4 activation both in vitro and in vivo. To demonstrate the general applicability of this methodology, we further developed small-molecule competitive inhibitors of TLRs.
11:35 Luncheon Presentation (Sponsorship Opportunity Available) or Lunch on Your Own
12:05 pm Session Break
1:15 Chairperson's Remarks
Christopher Smith, Ph.D., Director, Medicinal Chemistry, Takeda
1:20 Identification of RORc Inverse Agonists with Favorable in vivo PK and in vivo Suppression of IL-17
Benjamin Fauber, Ph.D., Scientist, Small Molecule Drug Discovery, Genentech
RORc is a promising target for the treatment of inflammatory disease. Signaling through RORc is critical to the differentiation of pro-inflammatory interleukin-17A+ T helper cells. We identified potent and selective RORc inverse agonists using structure-based drug design principles. Compounds in this series displayed favorable in vivo PK properties and modulated IL-17 in a dose-dependent manner during single dose PK/PD experiments. The improved compounds also possessed appreciable selectivity for RORc over other nuclear receptors.
1:50 Discovery of Novel RORγ γinverse Agonists for Targeting TH17 Pathway
Jianhua Chao, Ph.D., Associate Director, Medicinal Chemistry, Biogen Idec
RORγt is a ligand-regulated transcription factor and is required for the development and function of multiple important pro-inflammatory lymphocyte lineages including TH17 cells. RORγt-expressing cells and the cytokines they produce have been implicated in the pathogenesis of many autoimmune diseases. Disruption of the RORγt /TH17 pathway by small molecule inhibition may provide useful therapeutic intervention. We have explored multiple series of inverse agonists, achieving potent inhibition of the target and with associated acceptable properties for further investigation.
2:20 Animal Models of Ocular Inflammation and Their Translatability to the Clinic
Claire M. Gelfman, Ph.D., Senior Director, Preclinical and Translational Services, Ophthalmology, Ora, Inc.
Achieving proof-of-concept in animal models of ophthalmic disease is a commonly desired prerequisite for advancing drugs into the clinic. The decision of the best model for evaluation depends on the disease indication under consideration, as well as the mechanism of action targeted by the therapeutic being tested. In addition, the choice of endpoints for the preclinical studies should mirror, when possible, those that will be evaluated in the clinic. In this presentation, we will review several ocular inflammatory models that recapitulate specific features of ophthalmic disease. Representative data will be presented, as well as validation with clinical comparators, when available. This approach can be applied to the early evaluation of new chemical entities, as well as repurposing of compounds validated in other disease indications. The accumulation of relevant animal model proof of concept data will give leverage to a program and play a critical role in making sound go/no-go decisions early in the development process.
2:35 Refreshment Break in the Exhibit Hall with Poster Viewing
New Targets, New Approaches?
FEATURED PRESENTATION: Site-Directed Ligand Discovery for PPI and Allosteric Enzymes
Michelle Arkin, Ph.D., Associate Professor, Pharmaceutical Chemistry, University of California, San Francisco
Protein-protein interactions and allosterically regulated enzymes have been challenging but important targets for probe- and drug discovery, especially in the inflammation field. We and others have found that fragment-based lead discovery can provide chemical starting points and furthermore serve as insightful probes of protein conformation. The Tethering method of fragment discovery links thiol-containing compounds to specific cysteine residues and therefore serves as a site-directed approach to interrogating 'cryptic' allosteric sites and protein interfaces.
3:50 FEATURED PRESENTATION: The Discovery of First-in-Class Drugs: Successes of Target-Based and Phenotypic Approaches
Jörg Eder, Ph.D., Executive Director, Novartis Institutes for BioMedical Research
An analysis of the origins of first-in-class drugs approved from 1999 to 2014 shows that the majority were discovered through target-based approaches. Of those drugs discovered in the absence of a target hypothesis (about 30%) most were found by a chemocentric approach and only a few come from true phenotypic screening. The implications for drug discovery strategies will be discussed, including viewing phenotypic screening as a novel discipline rather than as a neoclassical approach.
4:20 Session Break
4:30 Plenary Keynote Introduction
Gregg Siegal, Ph.D., CEO, ZoBio
Chemotype Coverage in Fragment, Phenotypic, & Deorphanization Screens
Brian K. Shoichet, Ph.D., Professor, Department of Pharmaceutical Chemistry, University of California, San Francisco
The numbing size of chemical space shouldn't prevent us from asking what screening libraries are missing relative to what we know to be biologically relevant. I explore the impact of chemotype representation on inhibitor discovery, fragment-based screens, whole organism phenotypic screens, and screens to deorphanize enzymes and GPCRs. Each case is framed by rough calculation and illustrated by specific experimental results. The libraries that result differ as much as the goals of the screen, but specific limits and optimization strategies emerge.
5:30 Welcome Reception in the Exhibit Hall with Poster Viewing
6:30 Close of Day
Wednesday, April 22
7:30 am Continental Breakfast Breakout Discussions
In this session, attendees choose a specific roundtable discussion to join. Each group has a moderator to ensure focused conversations around key issues within the topic. The small group format allows participants to informally meet potential collaborators, share examples from their work and discuss ideas with peers. Check our website in February to see the full listing of breakout topics and moderators.
Topic: Phenotypic screening and target-based approaches: what have we learnt?
Moderator: Jörg Eder, Ph.D., Executive Director, Novartis Institutes for BioMedical Research
Topic: What can medicinal chemists do better to discover safe and effective anti-inflammatory therapeutics?
Moderator: Christopher R Smith, Ph.D. Director, ChemistryTakeda California
Topic: Developing kinase inhibitors for chronic indications
Moderator: Bill Thomas, Ph.D., Scientist III, Medicinal Chemistry, Pharmacyclics (tentative)
8:40 Chairperson's Remarks
8:45 Discovery and Design of BTK Inhibitors
Longcheng Wang, Ph.D., Scientist III, Medicinal Chemistry, Pharmacyclics
Pharmacyclics' ibrutinib (PCI-32765) is a first-in-class small molecule inhibitor for Bruton's tyrosine kinase (BTK) under Phase III clinical development for B cell malignancies. It binds covalently to Cys481 of BTK and suppresses B cell receptor (BCR) activation of primary B lymphocytes. Ibrutinib's discovery and some of our recent work for identifying a backup covalent inhibitor for BTK will be discussed.
9:15 Development of a Bruton's Tyrosine Kinase Inhibitor, ONO-4059: Potential Treatment for Rheumatoid Arthritis & Systemic Lupus Erythematosus
Yuko Ariza, Ph.D., Associate Project Leader, Exploratory Research Laboratories II, Ono Pharmaceutical Co.
ONO-4059 is a highly selective, orally bioavailable inhibitor of Btk and Tec kinase activity with a potency (IC50) of 2.2 and 5.3 nM. Data from the ongoing Phase 1 study in hematology cancer demonstrated a promising efficacy in CLL and NHL with a favorable safety profile. Because ONO-4059 reversibly blocks BCR signaling in B-cells and function in monocyte, mast cell and osteoclasts, we hypothesized that ONO-4059 could be an effective therapy in RA and SLE.
9:45 Coffee Break in the Exhibit Hall with Poster Viewing
10:30 Discovery of a New Series of Small Molecule Bruton's Tyrosine Kinase Inhibitors
Mark Sabat, Ph.D., Principal Scientist, Medicinal Chemistry, Takeda
Bruton's Tyrosine Kinase (BTK) is a cytoplasmic tyrosine kinase that regulates immunoreceptor signaling pathways. Inhibition of BTK is postulated to be an efficacious therapy for multiple autoimmune diseases. BTK has a high structural similarity with the kinase LCK with only two residue differences present in the active site. This talk will explain how structural differences between BTK and LCK were exploited to discover a series of highly selective fragment derived candidate molecules.
11:00 PPIP5K 1 and 2: A New Class of Small Molecule Kinases for Anti-Inflammatory Drug Development
Huanchen Wang, Ph.D., Senior Scientist, Signal Transduction, National Institute of Environmental Health Sciences, NIH
PIP5K1/2 are two small molecule kinases that synthesize 1-IP7, an activator of virus-mediated, interferon-beta transcription. When this inflammatory signature persists, it can predispose humans to obesity, diabetes and age-related cognitive decline. PPIP5Ks therefore offer a new anti-inflammatory target. Structural and mutagenic studies have revealed PPIP5Ks utilize a surface-mounted, substrate-capture site that delivers substrate into the catalytic pocket. This "catch-and-pass" reaction mechanism offers a novel means for pharmacological targeting of this enzyme activity.
11:30 TYK2 Inhibitors and Their Role in IL12- and IL23-Pathway Signaling
Steven Magnuson, Ph.D., Associate Director, Discovery Chemistry, Genentech, Inc.
TYK2 is a member of the family of Janus kinases that are receptor-associated cytoplasmic tyrosine kinases with a central role in cytokine signaling. TYK2 is known to be a key mediator of IL12-and IL23-signaling, thus being implicated in diseases of chronic inflammation. Structure- and property-based optimization of screening hits to highly potent and selective TYK2 inhibitors suitable for in vivo studies will be described.
12:00 pm Close of Track
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Conference At A Glance
Epigenetic Inhibitors: Discovery to Clinic
The Future of Fragments and PPIs
April 21-22
April 22-23
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Another Red Sox-Yankees game moved to Sunday night
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SU draws two Friday night home football ESPN telecasts
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NCAA Tournament tip-off times for Sunday, March 30
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WOFX to carry U.S.-Canada hockey game Friday
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Glens Falls-based radio station WMML (1230 AM) announced today that they have reached agreement to carry New York Mets games for the third consecutive season.
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Comfort Hotel Great Yarmouth 14 Albert Square Great Yarmouth, EN NR30 3JH Phone: (44) 1493 855070 Fax: (44) 1493 853798 |
»Pleasure Beach
A must for anyone who likes candyfloss, loud noise, big crowds, fish and chips and the thrill of the roller coaster. The time to visit is from 7pm when the lights are lit and the sky invariably a surreal pink. Dare to try out the fun park's historic roller coaster. Terrify yourself on the Terminator, which twists and spins round 360 degrees - or simply enjoy the view of the sea, and the surrounding area from the sedate high-level monorail. For those who are truly daring, there's the white-knuckle Ejector Seat and, coming to the park later this summer, the new attraction the Devil's Drop. Open times vary greatly over the weeks, please check the website for a comprehensive schedule.
»Roller Coaster - Great Yarmouth Pleasure Beach
Also known as the Scenic Railway, the roller coaster at Great Yarmouth Pleasure Beach is a wooden one. This ride was built in 1932 and has remained operational ever since! Being one of the only operational rides of its kind in UK, and one of eight in the world, one must try it out. Interestingly enough, a 'brakeman' is required to ride with the train to control the speed of the roller coaster as there are no brakes on the track! It also holds a record for being the second tallest and the second fastest wooden roller coaster in UK. If you are the kind who is not terrified with simulated adventure, a ride on this historical roller coaster is a definite must!
»St Mary's Church
Located right in the middle of Great Yarmouth, St Mary' s Church is a christian place of worship from the 18th century. Initially overlooked by the Society of Jesus and also built by them in 1848, it was later taken over by the Diocese of Anglia who run the church to date. The structure was designed by renowned architect Joseph John Scoles and cost about 10,000 Euros. The interiors of this church boast of gorgeous stained glass windows that allow the rays of the sun to dance around in various colors. The stained glass was made by the famous Franz Mayer & Co and also installed by them between 1860 and 1890. This structure is known to be the most famous and also the only parish church in the town.
»Britannia Monument
Also known as the Nelson's Monument, this is a commemorative column built in memory of Admiral Horatio Nelson. The tower is situated on the Denes in Great Yarmouth, England. Erected in 1800s, it was designed by the architect William Wilkins. James Sharman, who was a member of the crew of the Victory, became the first custodian of this monument. It is known as the Britannia Monument as the statue of Britannia stands atop a globe on the tower, inscribed with the motto from Nelson's coat of arms.
»Great Yarmouth Outer Harbour
The town of Great Yarmouth is also known in the UK for it's large port, the Great Yarmouth Outer Harbour. This project though proposed to be built long time back, was only commissioned in 2007. The reason behind building a large outer harbour was for big ships like container vessels to be able to dock and unload. The project was successful as the first dock and unloading was done in 2009. Ever since the day the first vessel docked, this harbour has been busy throughout the year.
»Gorleston South Pier Lighthouse
Lighthouses and watch towers have always played an inherent part in the field of navigation as a boat or ships docking at any port depends on the direction the lighthouse emits. The Gorleston South Pier Lighthouse is a coast watch station as well, this structure was built in 1955 and has been operational throughout the year. Another lighthouse was previously located on the same site from 1852 to 1955. This coast watch station is quite important as it has to be alert for the HM coast guard.
Bradwell is a village located in Great Yarmouth. It is a destination for visitors in the surrounding areas because it is developed and looked almost urban-like. This parish is also known for it's distinguished schooling system and pedagogical curriculum. This parish, with a population of about 10,000 is proud of their schooling system with schools like Hillside Primary School, Lynn Grove High, etc. The Old Community which, which was once the parish's only school now serves as a clubs and activity center. The library is located in the community center. The bi-annual newspaper of the parish is called 'The Bradwellian' and is delivered to ever household within the community.
Caister-on-Sea in Norfolk, England is one of the most popular seaside holiday destinations falling on the "Golden Mile." The beautiful village is replete with wide, pristine beaches, quaint little cafés and pubs, and a plethora of attractions for the whole family to enjoy such as the Caister Castle and Motor Museum, and the famous Caister offshore lifeboat station. The town is also of prime historical importance and is dotted with fascinating Roman remains which are managed by English Heritage and date back to the 1st Century CE. Being a fun-filled tourist hot-spot the village offers numerous comfortable options as accommodation ranging from hotels and cottages to camping parks and bed and breakfasts, all ideal for the entire family.
»Scroby Sands
A shoal on the shore starting from the Caister to the south of Great Yarmouth, this sandbank is quite well known locally and in the surrounding areas. The shore is stretched across 6.4 kilometers (4 miles), it is made up of the North, Middle and South Scroby. This area is made up of many smaller shoals of which Scroby is the largest. The northern end of the shoal gets deeper while the southern tip remains shallow and broader than the rest of it. These sands have always been more popular for the ship wrecks that they contain.
»Berney Arms Windmill
Known to be one of Norfolk's tallest mill, the Berney Arms Mill is located just about four miles away from the town of Great Yarmouth. The mill was founded and built in 1865 to use and grind cement clinker. It was used for this purpose only until 1880 after which it was used as a drainage mill from 1883. After being used to drain out the marshy land in its surrounding, the Berney Arms Windmill was finally shut down in 1948. The structure was reopened after a series of restoration work in 2009. It is now open to public but is not accessible by road, but can be visited through a pre-booked group tour.
A well known sea-side village close to Great Yarmouth, Hopton-on-sea is a scenic place with much to do. This place plays host to an annual World Indoor Bowlers Championship that takes place in the month of January. Also, the village is equipped with holiday parks, amusement arcades and a couple of local pubs that are warm and friendly. Visit Hopton-on-sea for a nice quaint holiday or day visit.
»Vauxhall Holiday Park
Vauxhall Holiday Park is meant for holidaymakers. No matter what your budget is, this massive touring park has something for everyone. From accommodations that include chalets, caravans and pitches to amusement parks like the Indoor Tropical Waterworld, Treehouse Adventure Playground, Splash Zone and spa treatments, there is lots going on in this fun zone. Enjoy the feast laid out at The Reedcutters Restaurant & Carvery, their on-site eatery. While Regency Room is for the entire family where you get a dose of live music, comedy and more, V-Lounge is a cozy club for those who are 18 years and above. Explore Great Yarmouth with this holiday park as your base. You can be sure of a memorable time with family and friends.


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National Cooperative Bank (NCB) provides comprehensive banking products and services to community associations; including housing cooperatives, condominium associations and homeowner associations throughout the country. With over 30 years of industry experience, NCB provides services to more than 3,000 housing communities nationwide, working with over 600 property management companies. We are the largest lender to cooperative housing communities in New York City and one of the largest lenders to condominium and homeowners associations in the country. In 2013, NCB originated 425 loans totaling $719 million to housing communities for capital improvement repairs and to refinance existing debt. NCB's current portfolio for community associations consists of $372 million in deposits, including checking and saving accounts and 4,281 loans totaling $5.8 billion in assets under management. Our tenured staff and reputation in the marketplace makes NCB the bank of choice for community associations.
Financial Status:NCB reported earnings of $11.5 million through the third quarter of 2014. Total assets as of September 30, 2014 were $1.8 billion and total deposits were $1.4 billion.
Headquartered in Washington, DC, NCB has offices in Alaska, California, New York, Ohio and Virginia.


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Friday, May 1, 2015
About Gallery Night
Showcasing the city's vibrant arts community, Gallery Night is a long-time Madison tradition. Organized each spring and fall by MMoCA, Gallery Night offers art lovers and art novices alike, an opportunity to enjoy a wide variety of exhibitions, opening receptions, special events, demonstrations, and refreshments at venues throughout the city. For information on Gallery Night, please contact Kaitlin at firstname.lastname@example.com or 257.0158 x224.
Click here to find out how to participate in Gallery Night.
Future Gallery Night Dates
Friday, May 1, 2015
Friday, October 2, 2015
* Gallery Night typically falls on the first Friday in May and October each year, except when there is a major holiday conflict (as is sometimes the case in October).