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Research Topics
Genomes and Genes
| CKLiKSummaryGene Symbol: CKLiK Description: calcium/calmodulin-dependent protein kinase ID Alias: CKLiK, CaM-K1, CaMKID, CaM kinase ID, CamKI-like protein kinase, caM kinase I delta, caM-KI delta, caMKI delta, calcium/calmodulin-dependent protein kinase type 1D Species: human Top Publications
Research Grants
| Scientific Experts
Detail Information
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesEleftheria Zeggini
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Genet 40:638-45. 2008..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D... - Genotype score in addition to common risk factors for prediction of type 2 diabetesJames B Meigs
General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 359:2208-19. 2008..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone... - Clinical risk factors, DNA variants, and the development of type 2 diabetesValeriya Lyssenko
Department of Clinical Sciences, Lund University, Malmo, Sweden
N Engl J Med 359:2220-32. 2008..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts... - Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte functionSandra Verploegen
Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Blood 106:1076-83. 2005..Recently, we identified a novel Ca2+/calmodulin-dependent kinase I-like kinase, CKLiK, which exhibits restricted mRNA expression to human granulocytes... - RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulationSteven Haney
Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, USA
PLoS ONE 8:e64946. 2013.... - Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo populationMarco Alberto Gamboa-Meléndez
Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Diabetes 61:3314-21. 2012..Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects... - Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in KoreaEun Seok Kang
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
Transplantation 88:693-8. 2009..Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea... - Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam StudyMatthias B Schulze
Public Health Nutrition Unit, Technische Universitat Munchen, Freising, Germany
Diabetes Care 32:2116-9. 2009..We investigated whether metabolic biomarkers and single nucleotide polymorphisms (SNPs) improve diabetes prediction beyond age, anthropometry, and lifestyle risk factors... - Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetesHana Lango Allen
Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, U K
Diabetes 59:266-71. 2010..We investigated the hypothesis that common polygenic variants that predispose to type 2 diabetes might account for the difference in age at diagnosis... - Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell functionAnnemarie M Simonis-Bik
Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
Diabetes 59:293-301. 2010..In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of beta-cell function... - Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 studyTrine Welløv Boesgaard
Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
PLoS ONE 4:e7236. 2009.... - Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMIJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 59:751-5. 2010..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood... - Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohortJie Wen
Department of Endocrinology, Shanghai Medical College Fudan University, Shanghai, China
PLoS ONE 5:e9153. 2010..In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabetes GWASs and the metaanalysis, in a Han Chinese cohort... - Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriersXianshu Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Hum Mol Genet 19:2886-97. 2010..Upon further validation, these SNPs together with other genetic and environmental factors may improve breast cancer risk assessment in these populations... - Identification of new genetic risk variants for type 2 diabetesXiao Ou Shu
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
PLoS Genet 6:e1001127. 2010..Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS... - Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han ChineseDai Zhan Zhou
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, PR China
J Hum Genet 55:810-5. 2010..15(1.10-1.21); P=1.93 × 10(-8)). This large population-based study and meta-analysis further confirmed the modest effects of the JAZF1, TSPAN8/LGR5 and HHEX-IDE loci on type 2 diabetes in Chinese and other East Asians... - Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathwayRajesh Ramakrishnan
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
J Cell Physiol 227:609-17. 2012.... - Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese populationM Imamura
Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Diabetologia 54:3071-7. 2011..The aim of the present study was to ascertain the role of these four variants in conferring susceptibility to type 2 diabetes in the Japanese population... - Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traitsD Schleinitz
Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig 04109, Germany
Horm Metab Res 42:14-22. 2010..This is compatible with the modest effect size of these "second sweep" variants, which will require large-scale association studies on quantitative traits to clarify their role in the pathophysiology of T2D... - Underlying genetic models of inheritance in established type 2 diabetes associationsGeorgia Salanti
Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
Am J Epidemiol 170:537-45. 2009..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments... - Ca(2+)/CaM-dependent kinases: from activation to functionS S Hook
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Annu Rev Pharmacol Toxicol 41:471-505. 2001..Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms... - Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cellsYumi Ishikawa
Department of Signal Transduction Sciences, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
FEBS Lett 550:57-63. 2003..This sustained activation of CaM-KIdelta was completely abolished by Thr180Ala mutation and inhibited by CaM-KK inhibitor, STO-609, indicating a functional CaM-KK/CaM-KIdelta cascade in HeLa cells... - Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cellsToshiyuki Yamada
Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
Exp Cell Res 294:39-50. 2004..Because the gene exhibited about 90% homology with the human calcium-calmodulin-dependent kinase I-like kinase (CKLiK) gene, it was identified as a mouse homologue of human CKLiK... - Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neuronsHiroyuki Sakagami
Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
Eur J Neurosci 22:2697-707. 2005..Our present study provides the first evidence for the possible involvement of CaMKIdelta in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx... - Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growthAkifumi Kamata
Division of Histology, Department of Cell Biology, Graduate School of Medicine, Japan
Neurosci Res 57:86-97. 2007.... - Genome-wide discovery of Pax7 target genes during developmentRobert B White
School of Exercise Biomedical and Health Science, Edith Cowan University, Joondalup, Western Australia, Australia
Physiol Genomics 33:41-9. 2008..This analysis gives us greater insight into the direct functional role played by Pax7 during embryonic development... - A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophilsPeter Gaines
Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA
Exp Hematol 36:832-44. 2008..we have investigated the role of two members of the calcium/calmodulin-dependent protein kinase (CaMK) signaling cascade, CaMK I-like kinase (CKLiK) and CaMKKalpha, in regulating neutrophil differentiation and functional activation. - Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged DanesNiels Grarup
Steno Diabetes Center, Copenhagen, Denmark
Diabetes 57:2534-40. 2008.... - Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypesHarald Staiger
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
PLoS ONE 3:e3019. 2008..e., obesity, impaired insulin secretion, and insulin resistance... - Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus StudyX Lin
Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
Diabetologia 52:600-8. 2009.... - Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian SikhsDharambir K Sanghera
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Hum Genet 54:162-8. 2009..on three genome-wide association (GWA) scans identified six loci (NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated with type II diabetes (T2D) in Caucasians... - Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adultsEma C Brito
Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
Diabetes 58:1411-8. 2009.... - CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancerAnna Bergamaschi
Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
Mol Oncol 2:327-39. 2008..Our findings identify CAMK1D as a novel amplified oncogene linked to EMT in breast cancer, and as a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors... - Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individualsS Omori
Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa 230 0045, Japan
Diabetologia 52:1554-60. 2009..To examine further the roles of these new loci, we performed a replication study for the association of these single-nucleotide polymorphism (SNP) loci with the disease in three independent Japanese populations... - Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinaseS Verploegen
Department of Pulmonary Diseases, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands
Blood 96:3215-23. 2000..This has been termed CaMKI-like kinase (CKLiK)...
Research Grants
- Study to Investigate the Pathophysiology of Type 2 Diabetes in YouthSonia Caprio; Fiscal Year: 2010..Our long term goal is to generate information on both the genetics as well as the pathophysiology of Type 2 Diabetes in Youth, which ultimately might guide us towards better preventive and treatment avenues. ..
- Cohort Study of Cancer inhibitory Factors in MenXiao Ou Shu; Fiscal Year: 2006....
- Cohort Study of Cancer-Inhibitory Dietary Factors in MenXiao Ou Shu; Fiscal Year: 2007..The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men. ..
- Breast Cancer Survival: Lifestyle and Genetic DeterminantsXiao Ou Shu; Fiscal Year: 2009..The proposed study, built on successfully implemented cohort studies, will be extremely timely and cost-efficient. ..
- Vanderbilt-Shanghai Chronic Disease Research Training ProgramXiao Ou Shu; Fiscal Year: 2009..This program will have significant impact on chronic disease research and prevention in China, and possibly extend to other developing countries. ..
- Breast Cancer Survival: Lifestyle and Genetic DeterminantsXiao Ou Shu; Fiscal Year: 2010..The proposed study, built on successfully implemented cohort studies, will be extremely timely and cost-efficient. ..
- Soyfood, gene polymorphisms and endometrial cancer riskXiao Ou Shu; Fiscal Year: 2005..Consumption level of soyfood is high and hysterectomy rates are extremely low among Chinese women, providing a unique opportunity to test the hypotheses posed in the application that are difficult to be evaluated in the U.S. population. ..
- MALIGNANT GERM CELL TUMORS IN CHILDRENXiao Shu; Fiscal Year: 2001..The relatively large sample size will provide sufficient statistical power to address the hypotheses being investigated. ..
- Cohort Study of Cancer-Inhibitory Dietary Factors in MenXiao Ou Shu; Fiscal Year: 2010..The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men. ..
- Soyfood, gene polymorphisms and endometrial cancer riskXiao Ou Shu; Fiscal Year: 2010..abstract_text> ..
- Soy Food and Coronary Heart Disease in WomenXiao Ou Shu; Fiscal Year: 2007....
- Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in AsianDharambir K Sanghera; Fiscal Year: 2010..Identifying the susceptibility loci in a population with high diabetic/cardiovascular risk may be important beyond Indians and will increase our understanding of the disease in other groups. ..
- Common Genetic Variation and Diabetes Traits in FraminghamJames B Meigs; Fiscal Year: 2010..Expanded knowledge of genes predisposing to type 2 diabetes and their interaction with obesity is critical to identify novel strategies for prevention and control of the worldwide diabetes epidemic. ..
- Common Genetic Variation and Diabetes Traits in FraminghamJames Meigs; Fiscal Year: 2009..Expanded knowledge of genes predisposing to type 2 diabetes and their interaction with obesity is critical to identify novel strategies for prevention and control of the worldwide diabetes epidemic. ..
- Role of Lamin B Receptor in Neutrophil Maturation and Functional ActivationPeter Gaines; Fiscal Year: 2007..The results may also offer important insight into the pathogenesis of potentially fatal hematologic disorders. ..
- Phenotype-Genotype Interactions and Type 2 DiabetesJames Meigs; Fiscal Year: 2005..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
- Epidemiology of Precursors to Type 2 DiabetesJames Meigs; Fiscal Year: 2007..Expanded knowledge of precursors of type 2 diabetes is critical to identify novel approaches for prevention and control of the widening diabetes epidemic. ..


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Product Number: | KGM900543 |
Item Price: | $35.99 |
Availability: | In Stock |
Shipping Weight: | 1.04 lbs. |
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text: | Rodgers: A long lost brotherFebruary 7, 2011 - Pam RodgersWhile I still maintain that I was neutral for the Super Bowl, I have to admit a little part of me wanted the Packers to win. The only thing I ask for every year from the Super Bowl is for it to be a good game, and that is exactly what we got Sunday. Both teams showed why they deserved to be there, and I was glad to see the green and gold come out on top. One reason I wanted Green Bay to win is I really like Aaron Rodgers. My brother claims him to be a long-lost brother because he spells his last name correctly. I roll my eyes at James when he says that, but I do like that he has a 'd' in his name, making us both members of the rebel Rodgers clan. My brother draws another similarity to Aaron because James was quarterback in high school and his number was 12 so, even though he's a die-hard Cowboys fan, he can't help but root for Rodgers. Rodgers was well deserving of the Super Bowl MVP. He will always be compared to Bret Farve, but I feel like this is a step in the right direction to separate himself as another great quarterback for the Green Bay Packers. Congrats to the Packers! Article CommentsNo comments posted for this article. Post a Comment | Blog Photos |


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Garden Talk: Herbs & Spices for Good Health
Sat, Oct 5, 2013
Times: 11:00 - 12:30 pm
Venue: Wistariahurst Museum
238 Cabot Street, Holyoke, MA 01040
Contact:Marjorie Latham
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Master Gardener Chris Brown will discuss how to cook delicious goodies using spices and herbs from your garden. Brown will provide samples of herbs and spices as well as recipes for dishes that include these wonderful herbs and spices. Talks and workshops are presented by the Wistariahurst Museum Gardeners and Western MA Master Gardeners. The cost of all talks benefits the garden restoration at Wistariahurst Museum. $5 suggested donation
5 Fabulous + Fun Things to Do on Martha's Vineyard in the "Off-Season"
Because really, the "off-season" on Martha's Vineyard is actually on. Sure, the Island...
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Assam HSLC results in www.sebahslc.com
2013 Results are expected by 20th May 2013–more info here.
RESULTS LINK: http://www.sebahslc.com/
RESULTS LINK – http://resultsassam.nic.in/
Board of Secondary Education, Assam, Bamunimaidan, Guwahati in their official website has notified that the HSLC 2012 RESULTS COMING SOON.
According to media reports and other results websites, the Assam Board of Secondary Education's HSLC results are likely to be announced around 12 Noon on 15th June 2012.
As of now the results of HSLC examinations are not uploaded in the official website.
Hence we request all the SEBA HSLC students to check their HSLC results after 12 Noon today.
We wish good luck to you.


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We now have over 100 images of the Audi R18 TDI's. The latest additions are detailed shots of the technology and carbon design behind these beast. Last weekend we witnessed the R18's crushing Le Mans testing the time sheets.
In just under 2 weeks time, Audi and Peugeot will due battle at the 1000km of Spa‐Francorchamps. Although Peugeot raced their new prototypes at the 12 Hours of Sebring, this will be the first time both manufacturers are racing new cars against each other. Audi did run the R18 the following week as was lapping seconds faster. It has bot run under race conditions.
Post your bets!


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- The Rap Sheet - http://blogs.denverpost.com/crime -
One juror sided with accused chicken parts vandal
Posted By Jessica Fender On September 20, 2011 @ 5:38 pm In District Court,General,Politics | 2 Comments
The jury is still out in the trial of state Capitol lobbyist Ron Smith, who is accused of stuffing chicken into his wife's air ducts as well as other less stinky acts of vandalism.
But today two alternates – unfortunates who spent a week listening to testimony without getting a say in the verdict – were released.
Antonio Salazar, 25, said he would find Smith "not guilty" even though he won't get the chance to debate a case [2] with little physical evidence, but mountains of the circumstantial kind.
"They didn't have any evidence. None," Salazar said. "He just didn't seem like the type of guy who'd do something like that. I think the other defense attorney had it right when he said the ex-wife was out to get him [3]."
Defense team Kathryn Stimson and Michael Evans suggest that Smith's ex-wife, the re-married Michelle Young trashed her own piano, marred her own floors, wiped her own computer and put chicken into her own air ducts in an attempt to frame Smith.
Prosecutors Courtney Johnston and Shannon O'Connor point to increasingly extreme and threatening e-mails, text messages and actions leading up to the September 2010 break in at Young's house and ask, who else would have hated her enough to do this?
No matter what the jurors decide, Smith isn't winning.
Even if he doesn't face criminal penalties [4] for felony criminal mischief and burglary, his reputation and his career have taken a hit, according to his attorneys.
Not to mentions Smith's picture is the third thing to come up when you Google image search "chicken lobbyist." [5]
Article printed from The Rap Sheet: http://blogs.denverpost.com/crime
URL to article: http://blogs.denverpost.com/crime/2011/09/20/chicken-lobbyist-ron-smith-tria/1428/
URLs in this post:
[1] Image: http://blogs.denverpost.com/crime/2011/09/20/chicken-lobbyist-ron-smith-tria/1428/ronald-dean-smith-jpg/
[2] debate a case: http://www.denverpost.com/news/ci_17138376
[3] he ex-wife was out to get him: http://www.denverpost.com/breakingnews/ci_18896300
[4] face criminal penalties: http://www.denverpost.com/news/ci_17148246
[5] when you Google image search "chicken lobbyist.": http://www.google.com/search?tbm=isch&hl=en&source=hp&biw=1272&bih=638&q=chicken+lobbyist&gbv=2&oq=chicken+lobbyist&aq=f&aqi=&aql=&gs_sm=e&gs_upl=647l3062l0l3222l16l14l0l6l6l0l321l1513l0.5.2.1l8l0
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We enlightened folks of the 21st century often look smugly and condescendingly at the gullible people of the 19th century who bought into various forms of "snake oil." But the fact is, they couldn't hold a candle to the ignorance and credulity of our generation. And it's not just homeopathy; it's the majority of nostrums and supplements on the shelves of drugstores and supermarkets. Homeopathy is just the tip of the iceberg, in terms of worthless products and therapies (acupuncture, subluxation, therapeutic touch, magnets, etc.) purported to make us healthier. All they really do is lighten our wallets.
Thanks to a law passed by Republicans in 1994 to please Orrin Hatch's donors in the Utah-based dietary supplement industry, the FDA has been rendered virtually helpless in trying to make sure that pills, tonics, and sprays (That means YOU, "Airborne!") actually are safe and effective. Consequently, most of them aren't. But Americans continue to shell out billions of dollars for substances that have not even been tested, much less approved by any recognized authority. It is perfectly legal, for instance, for someone to bottle mud and sell it as a "mineral supplement," as long as they don't claim, without proof, that it cures disease. The FDA can warn people about it, but they can't prohibit its sale without first proving that it fails to deliver what it promises, which takes years. But for every product that finally gets tested, 20 others hit the market shelves, untested. And we (well, not ME!) are stupid enough to buy them.
Perhaps most discouraging of all, whenever the information put out by the FDA, EPA, CDC, NIH, etc. conflict with ads on TV, the overwhelming majority of Americans believe the ads rather than the science. It's just another example of the disdain Americans have for science. It's why half of all Americans don't believe in evolution.
Check out any of the ads for health support products on TV. Nearly all of them consist mostly of warnings of possible dire effects (to forestall lawsuits); and many of them point out in the tiniest print, that the product hasn't even been tested for efficacy. Still, people spend their hard-earned money on them, despite the fact that they are demonstrably useless, if not downright dangerous.
This pisses me off. It's preying on the ignorant--aparantly a profitable business model. What an embarrassment to our society that we allow this to go on.
I'm struggling with homeopathy with my wife at the moment.... I insist it's complete hokum, and she agrees, and then she buys it anyway because it makes her feel better.
Also, from wikipedia:
10−24 |
Has a 60% probability of containing one molecule of original substance if one mole of the original substance was used. |
The dilution is so great that there are no traces of the "active" ingredients remaining. Explained here with humor.
Homeopathy is given credit when in fact people would be cured with or without it. People will give credit to all sorts of false causes. So at best it is a placebo when it 'works' for mild illnesses and it is dangerous when it doesn't for serious illnesses. Homeopathy is just one big logical fallacy, it's the classic post-hoc fallacy.
If homeopathy worked, wouldn't sea water cure everything?
I found a website that is called "How does homeopathy work" Here is the link
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BIOGRAPHY Rafael Verga, born July 27, 1981, in Florianópolis, Santa Catarina, Brazil, is a professional male model.
The Brazilian-born hunk is the new face of 2xist underwear and he is quickly making a name for himself on the modeling scene. His body is perfection, and he pops up in many ads and photo spreads in America and South America. His first job was a commercial for L&G, como figurante, in 2000. These days, he's in demand and very busy with upcoming photo spreads for companies such as Calvin Klein and Fruit of the Loom. With an Aussie Bum campaign on the horizon, we're sure to see more of that body in the months to come. He stands 6 feet tall and weighs between 170 and 185 pounds. He has light brown hair with hypnotic green eyes. Those piercing eyes and perfectly toned abs guarantee that he will be one stud to reckon with for a long time. He says he is honest and that his flaw is believing everyone. He loves food, especially rice, beans, and burgers. During his spare time, he loves to go to the beach and surf, which is his number-one hobby. The most important moment in his life so far was when he piloted an airplane for the first time, and he hopes to work as a pilot one day. A dream trip for him would be to visit Indonesia with friends. View GALLERY:
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text: Important notice: To access a database click on its title. If you are not on campus, you will be required to type in your library barcode. All databases can now be accessed from off-campus computers. If you have not activated your barcode, please do so at the Circulation Desk. Social security numbers will no longer work for off-campus users.


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NKOTB Concert in West Palm Beach is Canceled
Categories: News
NKOTB - so close, yet so far |
"Unforeseen production delays," according to Live Nation reps, have forced date and venue changes on the tour, and the the Tampa date, scheduled for May 30, as well as the West Palm date, originally scheduled for May 31, are both straight-up canceled. Refunds are available at point of purchase.
BTW, the Birmingham, Alabama show and two North Carolina dates were canceled too. Wonder if "production delay" is really a euphemism for something else? Super-fans, where are you to set the record straight?
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Merry (Day After) Christmas! – Holiday Skittle Mani
Happy Holidays Everyone!
Sorry this post is a day late, but it's still Christmahanakwanzika season so it still counts… Right? I hope you all had a great Christmas if you celebrate. I've just got a quick post for you today of a holiday skittle mani that I did on Christmas Eve. I used Color Club's New Bohemian and several of the polishes that Dana (Merry Christmas girl!) sent me last month. I ended up hating it and re-painted my nails afterward because I was being a grinch, but now that I'm looking at the pictures a few days later I think it turned out pretty cute!
I used one of the three stamping plates sent to me by KKCenterHK, the one that has the snowflake on it (B61). The plates they offer are inexpensive, but they do not have the cardboard backing like BM or Konad plates. The plastic film on the plates that you have remove before using them is also ridiculously hard to peel off. It's super thin, like fine saran wrap, and it kept tearing off in pieces. Even after I managed to remove most of it there's still a few shreds clinging to the sides of the stamping plate. Beside that, the pattern transferred nicely onto my nails. I'll show you more stamping designs with the other two plates when I have time to try them out.
Holiday Skittle Mani
Let me first mention that New Bohemian is a pain in my ass to work with. I don't know if I got a bad batch or what, but it was a streaky/gloopy mess. It took me three coats to get it opaque and mostly streak free. Annoying for such a pretty color!
I can't remember the names of the polishes Dana sent me off the top of my head. I used a holo bar glitter on my ring finger (love it!) from what looks like a foreign brand. I'm holding the bottle for it in my pics. On my thumb I used a vintage gold glitter by Wet n Wild. And I stamped with the B61 KKCenterHK plate on my pointer, middle, and pinky fingers. I used China Glaze Millennium and Sally Hansen White On for the stamped snowflakes. I then layered Confetti's Ice Ice Baby over it.
Here's some quick shots of the nail plates that were sent to me. I think only two of them would make good full nail designs, the rest are way too small unless you're painting the nails of a 3 year old.
Coupon Code!
KKCenterHK was nice enough to provide me with a coupon code for you all to use, it'll give you 10% off any purchase made on their site! The coupon is good until the end of February (2/28).
*Some of the products in this post were sent to me for unbiased review consideration.
This entry was posted by Rie on 26 December, 2011 at 5:00 am, and is filed under Holiday, Indies and E-Tailers, NOTD. Follow any responses to this post through RSS 2.0.You can leave a response or trackback from your own site.
Oh Rie!!! First things first,,… looking at your swatches always results in an addition to my WishList… so I have been avoiding your blog before Christmas I'm back in full swing now
It does sound like you got a bad batch because I have this collection and love this colour (I have worked with it three times already… full manicures that I wore for a few days) and I love the shade, formula and drying time.
so sad that it isn't working for you.I ADORE what you did with this shade! The layering of glitter and the snowflakes are such a perfect winter-scene mani… just lovely!
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PROBABILITY OF PRECURSOR VOLCANIC ACTIVITY Detectable volcanic activity may precede the largest cohesive and noncohesive lahars, but this is not a premise on which the planning process can rely. As demonstrated by the flow record over the last thousand years (a period including lahars that exemplify each of the planning cases), no flows correspond to the single known episode of major activity during that time (tables 1 through 4). A correlation with precursor events is suggested by the concentration of large flows, such as the Osceola Mudflow and Paradise Lahar, during the mid-Holocene when many tephra-producing events occurred. This association, noted by Crandell (1971) and Mullineaux (1974, p. 17), does not relate the flows directly to volcanism but is evidence of a linkage that may lack better definition only because of the confidence limits on radiocarbon dating. The potential nonvolcanic causes of both the cohesive and noncohesive debris flows and of the relatively small debris avalanches at Mount Rainier include (1) regional, nonmagmatic seismicity; (2) edifice effects; and (3) several phreatic effects of the active hydrothermal system, including rapid ice or snow melting, steam eruptions, failure in response to increased pore pressure, and lubrication of potential slip surfaces such as those of previous deep-seated failures again buried by edifice construction. The first two effects are discussed further here. Mount Rainier is the site of occasional small earthquakes, the largest two of which may have been due to a strike-slip fault on the south side of the volcano (Crosson and Frank, 1975; Crosson and Lin, 1975). Nevertheless, the general areal distribution of historical earthquakes, such as a cluster of seven earthquakes in 1987 with magnitudes of 0.8 to 2.1 at depths less than 5 km shows a clear association with the volcano (University of Washington Geophysics Program, written commun., 1988). These earthquakes may be the result of edifice effects. Like many subduction-related stratovolcanoes, Mount Rainier is noteworthy for the large mass of layered material at high altitude, leading to gravitational stresses such as those described as edifice effects in a study of Hawaiian volcanoes (Fiske and Jackson, 1972). Some microearthquake activity at Rainier was ascribed to these crustal-loading effects (Unger and Decker, 1970), a view later modified (Unger and Mills, 1972). Some low-frequency tremors recorded at Longmire may result from glacier or debris flow movement in the Tahoma Creek, Kautz Creek, or upper Nisqually River drainages. The Rainier area is subject to large regional earthquakes (Gower, 1978). If the Cascadia subduction zone offshore is storing the elastic energy characteristic of other subduction zones, several great earthquakes are necessary to fill the seismic gap represented by the zone (Heaton and Hartzell, 1987). The deep, plate-boundary earthquakes of 1949 (M 7.1) and 1965 (M 6.5), both with epicenters on the east side of Puget Sound, caused local incidences of rockfalls, slope failures, and flood-plain liquefaction throughout much of western Washington (Schuster and Chleborad, 1989). As many as five great earthquakes have occurred in the last 3,100 years, the latest about 300 years ago, as suggested by the stratigraphy of buried wetlands in southwest Washington (Atwater, 1988). Major slope failures can occur, however, in response to minor seismic accelerations at times of high susceptibility; for example, the largest historic landslide in Canada was probably triggered by a small (M 3.1) seismic event (Evans, 1989). Many similar volcanoes have experienced collapses yielding large debris avalanches; Mount Rainier is apparently unusual because the large collapses have transformed directly to lahars, but more detailed study may show this also has occurred at some other volcanoes. Major sectors of the mountain are composed of steep, outward-dipping lava flows (frontispiece) between which hydrothermal water has infused and altered material to clay-rich zones that are potential slip surfaces (fig. 22). Where exposed at the surface, these zones range from 0.2 to several meters in thickness. At depth, hydrothermal alteration is doubtless more intense. Consequently, volcaniclastic flows beginning as large debris avalanches from Mount Rainier may have little correlation with the warning signs of an eruption. Only one of the modes of collapse described by Francis and Self (1987) requires precursory activity. Moreover, Siebert (1984) found a uniform relation between the height of origin and the runout distance of debris avalanches, regardless of whether the initial slope failure was induced by an explosion or merely by gravity, indicating that the energy from an explosive initiation does not increase the runout distance and thus does not increase the hazard.
pp/1547/sec5.htm Last Updated: 01-Mar-2005 |


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Team Bobby Falls to Three
by Sara Levine in Food Network Star, June 5, 2012When it came down to Eric Lee and Ippy Aiona in the Producers' Challenge, Bob and Susie said it was one of the toughest decisions they'd ever faced in eight seasons of Star. Both talented chefs consistently impressed everyone with their food, but struggled to find a sweet spot on camera. In the end, Team Bobby's Eric was the one to say goodbye.
Eric left the pitch room with the same humble, gracious attitude he maintained throughout the competition. "I just want to thank you for the opportunity to work with Bobby," he told the judges. "It is just incredible how great of a mentor he is." Bobby, in turn, had high praise for his mentee: "Eric may be the best cook in the entire competition."
Hear more from Bobby, Susie and Eric in his exclusive exit interview. Do you think Eric deserved to go home?
Flip through Eric's Star Scrapbook and more behind-the-scenes photos from Episode Four.
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A Letter to Lenny, from the Rebel
Dear Lenny, Out of all the seasons of Food Network Star, I can think of only one other winner who has a personality as big as yours. Congratulations a...Comments (
170 )-
It is ridiculous that Eric had to go. There are plenty of other less talented and not very interesting people on the show that should have gone before Eric.
Bobby was right when he described Eric as the best chef this season. And the judges loved his dish!
I am glad they kept Ippy!
But---it should NOT have been those two on the bottom in the first place!
It should have been some others.
I agree. Eric has a great pov and his personality was friendly and energetic. Although not great in front of the camera, who there is? His cooking was great and he was obviously smart with his food. Others are saying he had a dull personality. Ippy was better????? He is way too dull and layers back for a cooking show. They made the wrong decision. I don't like this whole team thing. Others who are far worse are being saved by the rest of the team. Also, the team leaders are helping them way too much for the sake of winning for themselves. Let the chefs cook on their own. Bring Eric back.
I completely agree with you. Ippy continues to say where he is from but has not shown anyone what that means. Eric is bringing back an approach to food that has been lost for many generations. I know few who cook from scratch and understand what that means. I wanted to see more of his hand crafted food. How is it that the network can't see this as a draw?
I agree! Less personality, more know-how!
Greg, I completely agree with you. Eric's fish sticks were great (as stated by Tuschy). His food should have kept him in (especially when both Marti and Judson's food were less than stellar).
At the time it happened, I feel it woulda made alot more sense to have, say, Judson and Martie be on the bottom 2.
Eric could cook! I would have liked to see more of what he could do with fresh ingredients from scratch.
His presentation was lacking, But as Bobby has said: If you can cook, I can teach you on camera (to that effect). Its even better if someone has a strong knack at both--but I will say in my opinion: Food 1st.
To use a very extreme example (just to drive home the point)--suppose we had some lingerie super-model who made thousands of viewers watch, but who only tell us how to make a so-so plate of Mac & cheese? It wouldnt last.
Eric's presentation could have improved. there are others who should have gone before him who dont have the cooking ability.-
I want to hear more about this super-model making mac n cheese!
What times does the mac n' cheese show start? I need to make space on the DVR. And why don't you have a job pitching ideas to the FN?
hehehehe...ahhh, yer too kind. Thanks.
(I could always use a better-paying job, though).
At the time it happened, I feel it would have made a lot more sense, too. Perhaps the interesting cooks, like Eric and Josh, can get jobs on the Cooking Channel.
Absolutely the wrong decision. Send the best chef home? Bob. . Susie. . .you made a bad call.
[...] post: Team Bobby Falls to Three This entry was posted in Food Network and tagged bobby, great, ippy, lee, mentor, scrapbook, [...]
This "team challenge" thing is allowing a pass for clear losers of the week. Each week, its seems, an obvious member of the bottom two is saved by his/her team. With this in mind, we could have a scenario where half of the remaining top six are the worst contestants. Wrong way to do it.
i did NOT like eric at all. im glad he went
Jessica, you're an idiot. Who wouldn't like Eric?
It was almost like since Giada lost a team member last week the powers that be didn't want her to lose a team member two weeks consecutively. That's not right! I am disappointed that Eric had to go. Susie talked about seeing raw talent in Ippy, but I saw it in Eric too. I think the "producers" think that Ippy's appeal was greater than Eric's.
Did you see the look she gave the judges right before they sent them out so they could talk about the two chefs.
Though i didn't HATE Eric, i was glad he went home. His personality was as dull as shepard's pie. (If you've read Aarti's blog you get my pun.)
No one reads Art's blog. She is as dull as it gets. TG FN cancelled her show.
I am very disappointed in general at the way the Judges are handling this season. Eric was clearly one of the best chefs that has ever been on the show, and it is a tragedy he went home as early as he did! I also think Nikki is great. I don't get where the judges say she is scripted... I think she is fun, spirited, and eloquent when talking about food.
I think Judson should go for claiming that "Great cuisine plus exquisite Fashion equals Love" is his mantra. That was such a transparent lie, he should be tossed out the door.


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The resurrection of Shanghai, 2.0
PUBLISHED: 26 Oct 2012 00:02:07 | UPDATED: 27 Oct 2012 01:48:19PUBLISHED: 26 Oct 2012 PRINT EDITION: 26 Oct 2012The members of the Harvard Medical School Class of '08 were exceedingly ambitious — even by Harvard standards. Not content merely to graduate from America's top medical school, a small group of them set out to found an entirely new campus of their alma mater abroad.
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Girlfriends' weekend away; the perfect way to bond before the big day
By Suzanne Witt & Jennifer Mifflin
Beauty abounds: Cliffside at The Reefs, the view is spectacular. | PHOTO COURTESY OF THE REEFS HOTEL & CLUB
Editor: John K. Ryan firstname.lastname@example.com | Cover Design: Jennifer Frencl Page Design: Kristy Smolkovich Cover Photo by: Joe Walsh, Images of Ca melot To Advertise: John Doolin (708) 633.6808| specialsections.suntimes.com
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During the first week of August last year, a tropical storm was headed to Bermuda … and as fate would have it, so were fellow writer Jennifer Mifflin and me, come hell or high water – literally. Months earlier, we concluded it would behoove us to take in firsthand what neither had when tying the knot: travel to a refined and temperate destination with unspoiled beaches, where relaxation and celebration pair perfectly; a much-deserved "bachelorette" weekend away from the stress, phone calls and loose ends leading up to the big day. Truth be told, we were two good pals curious as to how this relatively recent phenomenon picked up such momentum among bridal parties and friends in lieu of a casual soiree within close proximity to home.
Bermuda always has been an oasis of sorts and actually consists of seven main islands and many smaller islands and islets, situated about 650 miles east of North Carolina. It is divided into nine parishes and two municipalities. As the oldest self-governing overseas territory in the British Commonwealth, it boasts one of the highest per capita incomes in the world and an extraordinarily healthy economy. Historically rich architecture, verdant flora and fauna and an array of activities and attractions make for an unforgettable experience anytime – and an exceptional retreat for soon-to-be-brides or grooms where there is always something to see and do.
Car rental is prohibited – taxies, busses, mopeds or ferries are the way to go. We were paired with Oliver Bain our entire stay – an amiable, articulate and fascinating individual who graciously drove us anywhere and everywhere while offering unparalleled perspective and conversation.
Paradise found
Our first stop was Elbow Beach, a Mandarin Oriental property whose roots can be traced back to 1908, with 98 rooms and suites set on 50 acres of immaculately groomed gardens that lead to a ½-mile long private beach with pink sand and water as blue and clear as my daughter's eyes. It wasn't difficult to envision why the locale was high on the list for pre- and post-nuptial celebrations, as well as actual weddings.
"Elbow Beach is ideal for bachelor and bachelorette parties because our extensive facilities offer everything one could want for a beach getaway, and our central location makes us the ideal choice, as a range of fantastic activities are nearby," said Sophie Dier, director of communications. "The resort itself has private beachfront facilities, a swimming pool, putting green, five tennis courts, a dive shop, luxury holistic spa, cycle rental facility and four restaurants and bars. All these amenities offer plenty of ways for guests to entertain themselves while staying at the resort."
Our accommodations were personal and pristine; a suite with a superb ocean view, patio, designer bathroom, high-end conveniences and Champagne, cheese and fruit for our enjoyment. The room provided plush and inviting quarters after full-day shopping and sightseeing excursions to Hamilton – the capital just seven minutes away – and hours of basking in the sun, sand and surf. We also were within close proximity to Mickey's Beach Bistro & Bar, casual and unpretentious on-the-beach dining with myriad fresh seafood selections, and the Sea Breeze Terrace, where we indulged in sushi and tapas al fresco – pure bliss.
We did squeeze in time to visit Beau Rivage, Bermuda's only French restaurant, with panoramic views of Hamilton and Hamilton Harbour and skillfully prepared fare from Master Chef Jean Claude Garzia. Since Jennifer and I both appreciate gourmet cuisine this was high on our "splurge" list and did not disappoint. We relished Maine lobster ravioli and seared scallops and lemon pepper braised mussels with homemade pasta and scented fresh tarragon herb lobster sauce. Ample and inspired cold and hot starters, seafood, chicken and beef selections as well as a generous wine list beckon diners to savor every nuance and detail.
As a nightcap to our inaugural girls' night out, we headed to Harbour Nights and the Hog Penny Restaurant & Pub for a pint. Every Wednesday in the summer, Hamilton's Front Street is closed to vehicles and infused with energetic musical acts, enthusiastic dancing, local artisans and their wares, vendors tempting taste buds with Bermudian and international cuisine and residents and visitors mingling amongst the revelry and fun. Shops and restaurants stay open later to accommodate crowds. It's a lively and invigorating atmosphere that encourages carousing and conviviality. It also proffered the chance for us to pinpoint Gosling's, where we were headed the next morning for a 10 a.m. rum tasting.
Nothing says let-your-hair-down more than starting your day with a stiff drink. When we arrived at Gosling's, affable and enthusiastic Brand Director Andrew Holmes greeted us. Founded in 1806 by James Gosling, the Black Seal Rum – 80 proof – is quintessentially Bermudian. So well liked, it's often added to fish chowder and is the star ingredient in both the Rum Swizzle and the Dark N' Stormy. We had our first Dark N' Stormy from the get-go, and for me it's more of an acquired taste. It's essentially two ounces of Black Seal Rum in a chilled or ice-filled glass and ginger beer – almost like ginger ale but with a bit more bite and a lime garnish. It's a smooth, crisp and refreshing combo. We also sampled Gosling's Gold Rum, amber in hue with hints of vanilla, apricot, mango and subtle oak and Old Rum, aged gracefully and best for sipping — slowly. The history and lore of Gosling's — the only company that blends and bottles in Bermuda — are enough to encourage stopping in but the craftsmanship of the rum is what brings you back. Tours and tastings are a great learning and drinking adventure.
A hands-on experience
There's no denying we were fuzzy-headed and thrilled to the gills, post-Gosling's, to head back to Elbow Beach for two to three hours at the Spa. Already in a slightly tranquil state, the Spa would prove a panacea for letting go of what anxieties remained. With six private suites, it is a sanctuary of seclusion and peace. Holistic treatments are conducted in warmly colored rooms with organic textures, handcrafted granite soaking tubs, bamboo flooring and river-pebble-lined steam showers. My single suite had its own balcony with daybed for outdoor comfort. Mandarin Oriental's signature therapies last one hour and fifty minutes and are based on the expertise of specialists in Traditional Chinese Medicine (TCM) and skilled aromatherapists.
I've always been a bit tepid about spa experiences in general, hence the reason I did not visit one before my own nuptials. My reasoning is twofold: I'm not entirely comfortable having a stranger's hands on me, and I'm incredibly ticklish. I confided this to my therapist during our consultation, and she was totally reassuring and kind. She chose specific oils based on my current state of well-being that would align my body, mind and spirit. After the aromatherapy massage and customized holistic facial, my skin never felt cleaner or more refreshed: It was heavenly. There are whimsical indigenous treatments from which to choose as well — the Bermuda Pink Sand Scrub and Rum Swizzle Ritual — in addition to a full menu of services including massages, body wraps, manicures, pedicures, facials, hot stone therapies and half- and full-day packages.
As our time at Elbow Beach dwindled down, we gained introspective on the seductive nature of briefly absconding with close allies before a life-changing event like a wedding – and started to comprehend why nuptials abroad are a unique and romantic alternative and much less complicated than one may think.
"Something we have noticed is an increase in destination weddings, with the bachelor and bachelorette parties built in as part of the destination wedding program's schedule of events. Since people are already planning their destination wedding at Elbow Beach with their closest family and friends, many decide to just have the bachelor and bachelorette parties with the guests in attendance," Dier said.
Location, location, location
Our girls' getaway hadn't reached a finale quite yet.
We were headed to The Reefs Hotel & Club, set on limestone cliffs with its own pink sand beach. With 62 accommodations, all boasting ocean views, and 19 fully furnished two- and three-bedroom club suites, the 1947 resort is luxury at its best. It is a haven for families, couples, wedding parties and guests, as well as friends' excursions.
"Bermuda and The Reefs have long been a popular destination for weddings, family gatherings and girlfriend getaways. Destination bachelor and bachelorette parties are beginning to gain momentum [as part of a growing trend] of couples being slightly older when they get married and wanting a party that's more sophisticated," said Nagma Walker, general manager.
Jennifer and I were fortunate enough to stay in a two-bedroom club suite, part of The Reefs Club, available on a fractional ownership basis, as well as for rental. Aesthetically the interior was breathtaking, with floor-to-ceiling ocean views at every turn, a gourmet kitchen, living room and exquisite bathrooms. We even had a terrace and outdoor whirlpool at our disposal and were given access to additional luxuries: an infinity-edge pool, state-of-the-art-fitness center, rooftop putting green, pre-arrival grocery shopping service and on-site concierge.
There was not a single detail left dangling.
"The Reefs has an ideal beachfront setting, gourmet dining, award-winning spa, attentive service and perfect accommodations for elegant bachelor and bachelorette parties. The group can stay together, but with plenty of space, in the two- and three-bedroom condos with up to 2,500 square feet of living space. Daily rates include full-service breakfast, afternoon tea and nightly gourmet dinner, which make it easier for attendees to budget. Our front desk staff will work with parties on special requests, recommend activities and arrange private parties in one of our restaurants or an after-hours spa party at La Serena Spa," Walker said.
We quickly discovered eating choices were convenient and eclectic. Coconuts gave us the chance to watch the sun set, feel the breeze off the water and sip drinks at the Sand Bar; Ocean Echo offered more of a quiet and stately ambiance with a tremendous seafood display and Royston's, which stood out for its warm and inviting ambience and show kitchen.
Even amid a Portuguese Man-of War spotting and somewhat strong current, we knew a "must stop" our last day had to be Horseshoe Bay Beach – one of the most acclaimed beaches in the world – a mere 15 minutes by taxi. Claustrophobics be warned: It's crowded but easy enough to carve out your own niche. The white and pink sand, coral reefs and azure waters of Horseshoe Bay are stunning. Trails along the coast connect to other beaches and coves close by and are sometimes utilized for horseback riding. Although predominantly overcast, we still managed to spend significant time in the water and on the beach. We relived how we met our spouses, discussed our children in-depth, gossiped about favorite celebrities and rated brands of wine; things girls inherently talk about when they're together and not too busy or too tired from the reality of jam-packed schedules.
There's no doubt in our minds when taking the marital plunge, one last fete away from the everyday is in a class unto itself. We were able to decompress, consume countless calories and imbibe incredibly well, chat until the wee hours of the morning, obsess over reruns of "The Millionaire Matchmaker" while unwinding, sunbathe on breathtaking beaches and bond as two girlfriends do – all over again. Not only do you learn a lot about yourself on a trip like this, you realize what cemented your friendship in the first place. It's as plain as day why a bride-to-be would seek this camaraderie and support before embarking on the journey of marriage, in the Shangri-La that is Bermuda.


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Hello to all you out there, I'm looking for the rest of my Dads family. The KRENING, BREIWICK, KRONING of former Soviet Unoin, Norway. |
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DIY: Kids Halloween Costume Ideas
Halloween is quickly approaching us and if you haven't already started to think about costumes…well it's time to start thinking about what your little ones are going to wear. Picking out what to be for Halloween has been a hard one in my house and we usually wait till the last minute which isn't too good because most the costumes are picked over by then. If you have that same problem in your house then I'm sharing a few easy costumes ideas over on Smithfield.com today. You'll find an idea for a Hula Girl, a Chocolate Chip Cookie, and a Lady Bug. All of them are easy to put together on your own. The ideas range from buying a few key items at your local costume store to buying a few materials at your local fabric store. Stop by and leave me a comment on what your little one is going to be this year. Or if you have any ideas for easy costumes let me know. Would love to hear them!
Happy Halloween!!


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I'm really an old user.. maybe 7 years ago, many things have changed in my life since the last time i was here, i have time now, that's all. I'm good with people when i feel like it, of course it doesn't make me a lot of friends but now and then i would find people I'm compatible with. Important: I'm not very good at expressing my feeling especially sympathy. I welcome anyone e.g. rude, kind, fake etc... we all have our own interesting/redeeming qualities. |
-My name is Victor, or just call me Vic for short. -Im 21 and a male from New York -Can't really think of anything.. really. -Got into anime at a young age. 1st anime I saw was Sailor Moon but when I got older and I got more in depth with more shows thanks to Toonami and Adult Swim. |
the names claire and i'm 18 I'm from Nottingham in England (robin hood country) umm I've always been into anime and manga my first anime was cardcaptors :) errrr I also do martial arts and love music and K-drama |
Life is chess, are you a player or a pawn?
1. Kozou (a nickname I was given when I was 7 by a karate shihan - it just kinda stuck. I wanted it on my cr account but it was already taken so I went with the nearest approximation that wasn't being used)
2. 29/M/Scotland 3. Interesting: I taught myself to play the piano when I was 5 and subsequently passed all gradings without the need for a tutor. Weird: I'm allergic to onions. 4. I never slept through the night as a kid, my parents eventually got bored trying to convince me to go to sleep, instead they let me watch TV and I happened across a late night anime marathon. I was hooked instantly. |
xXfkyourtrunkXx wrote: 1. The name's Go. Naomi Go ;D haha James Bond reference for those of you who do not know :3 2. just turned 6teen/your average female/Chicago! 3. I'm full-blooded Mexican but I have some Korean too thanks to my great-grandma 4. Some friends in 6th grade read manga and one day while browsing the manga section at Borders, I found Kitchen Princess:3 And fell in love with it. My first manga <3 Anime-wise, they also showed me Shugo Chara!...which I was heavily devoted to for the next 2 years [: I love rock music, Foo Fighters and The Strokes <3 metal [ANTHRAXXX \m/] and some singers like Florence + The Machine and Lady Gaga...Gaga is the only pop singer I can tolerate actually rofl Anyways...I'm not going to bite:P Add mee <3 Ohai thar :3 |
Dont Judge me!! You Judger!! (╯°Д°)╯︵ ┻━┻
1) Aaron, as if you didn't guess that already :3 2) 24, male, England 3) Something interesting? 'kay... uh... I play guitar and do character sketches for a friend's stories >_> 4) Watched DBZ years and years ago, and then a few years back I got talked into watching Bleach, Code Geass and a few other things and just started again from that. |
Hello, I'm Anna!
I'm 17 and I'm from Germany. There is no interesting about me. I'm a little strange and I'm a Japan addict!! I think it began with Pokemon and Digimon and so on. The 'standard' Animes I would say. :D And with 12 I want more than Animes and Mangas, so I started with the music from Japan and was interested in the country. And now I'm 17 and I really love this country!! :D Oh, and sorry for my English. I'm not so good. :b |
Hi !nice to meet you! 1. I'm Kirimina Ebiko ( Pennname ) 2. 13 years old ( Birthday is in Jan 4 ) I'm a girl.. ( Duh. ) I live in Califronia :3 3. I tend to eat alot, enjoy waaaay to much otaku time, I watch anime alot and clearly for days LOL. 4. My childhood friend :O She introduced me to Inuyasha and everything when down hill from there~ Lets try and be good friends~! |
Animating an MEP. @_@
Didnt even see this till just now... like a month in lol
Yo, names Teddy, or star. whatever ud like. Live in York,PA, USA, M,16 Something interesting is i do parkour and act like an assassin from the game Assassins Creed.. eh thats it, if youd like to know more message me, im pretty friendly. And actually i only started wacthing anime like 6 months ago i think with Rosario Vampire on netflix, was hooked right then and there. |
Pain is inevitable, suffering is optional.
names mark like watching anime and boxing and any nerdy thing u can think of i probably do it. Single dad of 2 one boy and one girl loves of my life..other than that im a boring guy
Pardon me while I burst
22 ...... im boring.... :) a friend introduced me to naruto... i just got hooked... |
Hollie This sounds so awkward when I write it!
I'm 14 and from the UK I can only drink through a straw Even tea! How did I get into anime?... One day, I was sitting on my laptop, and I stumbled upon someone's naruto fanart, and it kinda went from there! I don't watch naruto any more, but that must be the best coincidence of my life! |
1. Germaine
2. 19/F/US 3. I can't think of anything right now... :( 4. I'm Asian, I don't remember any part of my life where I was not watching anime/playing video games. haha! |
Hi nice to meet you all
1. Kirimina Ebito ( Penname. ) 2. 13/F/Califronia ( My birthday is on January 4. ) 3. I like hearing good scary stories, and anime :3 4. When my friend introduced me to it when I was 9 years old and it went all down here from there. :3 Let's tryand be good friends~! |
Animating an MEP. @_@
1.) Luis
2.) 18, male, Los Angeles, CA 3.) Im a computer science major AT CSULA. 4.) i think the anime that got me into anime was Clannad and FMA. Ever since i got into anime i've always enjoyed Romantic, slice of of life comedies. My favoite animes would have to be clannad, say i love you, or Accel world. Favorite quote: When you smile, the Whole world smiles with you. |
Burn as hot as the sun!


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No-Knot Fas-Snap
Change hooks, jigs, lures or flies in just seconds with the No-Knot Fas-Snap and enjoy more time fishing. The innovative, lightweight No-Knot Fas-Snap is designed to be tied directly to your tippet or mono line. No-Knot Fas-Snap will not inhibit casting or presentation and it even floats with a dry fly! 30 per pack.
- Saves time
- Lightweight
- Ties directly to your tippet or mono line
Outdoor Answers
Get help about this item from fellow customers.
Ask your questions. Share your answers.
Therefore, you will match the size by what type of fishing you will be doing to match your 3/0 hook. Thanks
How small is the smallest size? What's the smallest size trout fly you could fit on the small "fast snap?"
Thank you!
You should be able to get a #10 or a #12 fly onto the small Fas-Snap.
Depending on what time of year, especially later in the summer when the flies are getting smaller this is a non starter for trout. Thats why I use flouro leader, 7x tippets, etc depending on how big the fish are where I am fishing. Trout with any pressure are too smart for this.


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That said, I am one of those people. Once a month or so I do a full grocery shop entirely at Leo's: Maggie Beer condiments, imported Italian pasta, juice squeezed from the bodies of virgins. The other mothers at school see the lunch I pack for my kids and think "Gosh, that Anna must be the heiress to a gigantic good taste fortune," and try to be more like me.
Eating breakfast at Wild is a bit like that. It's in a great spot, with the bay and the coin laundry and the RSL all within a cooee. I imagine on a proper summer morning those glass doors are opened out to welcome all the neighbourhood for a raspberry and quinoa muffin and oh the laughter rings out! Unfortunately, I chose that Wednesday morning when Melbourne was being battered by a juicy, horizontal rain, so the doors were closed and I was a (cold) prisoner inside.
It was my first day of Pancake Judgement, and I couldn't have been more excited. With good reason, as it turned out. For a start, my glass came with frozen grapes instead of ice cubes. "God damn!" I said. "I'm in a Donna Hay magazine! This is incredible!"
Ordering pancakes is a little different to ordering eggs. In a sense, the overall construct of the meal is chosen for you, and they differ quite a lot from place to place.
At Wild, the pancake option was Ricotta hotcakes with apple matchsticks, marscapone and strawberry curd. If you don't speak food, this translates in English to "Pancake with the joy of the almighty on top".
The first thing I noticed about the dish – even before the opportunity to play Pick Up Sticks – was the smell. When I closed my eyes, I could have sworn I was in an orchard, being hand fed strawberries by gorgeous men lathered in marscapone. Fortunately the actual visual was almost as good. Just look at it.
The hotcake itself was dense, but still had a good sponge to it and it was punctuated with chunks of cheese. The apple – Granny Smith, my favourite – was sour and crunchy and a perfect contrast to the sweet strawberry curd. I ate it like an excited kid, slurping the curd and eating apple matchsticks with my hands and reading The Magic Faraway Tree books.
Pancakes are so much cheaper than eggs! My wallet is celebrating. This harmony of fruit and cheese was only $12.50 if you can believe it. The rest of the menu looked about Elwood Standard, which is to say it was more expensive than the back streets of St Kilda but cheaper than Brighton.


text: Man Dangling off Crane with One Hand April 21, 2014 / Video / 1 comment Mustang Wanted (crazy Russian) show's us how to climb a 500 ft crane w/ NO FEAR! This is probably one of the craziest videos I've seen in a while. Even watching it on my iPhone made my stomach turn.


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Contact Sports Desk: Call: 603-516-2949 / E-mail: firstname.lastname@example.com Marshwood field hockey survives first round
Sunday, October 20, 2013
SOUTH BERWICK, Maine ― It took a little while for the Marshwood High School field hockey team to get going on Saturday, but when it did, it was in the driver seat in its Western Maine Class A tournament opener.
Four different players scored the Hawks' first four goals. Ashley Hickey and Lindsey Poirier found the back of the cage in the final minutes of the half to stake Marshwood to a 3-0 halftime lead. Karissa Boesch scored early in the second half to put Marshwood up 4-0.
Marshwood outshot Windham 13-2. Marshwood goalie Cassidy Smith came up with both saves.


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business & economy
Also in this section: Big Dig company makes news headlines, political problems ACP downplays its relationship with Parsons Brinckerhoff by Eric Jackson Back in 1985, in a consortium along with Bechtel, the US-based construction and consulting firm Parsons Brinckerhoff was given the contract to manage the construction of a project to relieve Boston's traffic congestion by burying its interstate highways in tunnels below the city. Dubbed the "Big Dig," at the time the project's cost was estimated at $2.6 billion. Fast forward to 2006 --- years behind schedule, the Big Dig was finally inaugurated, with the costs having risen to $14.6 billion and Bechtel/Parsons Brinckerhoff still managing the project. That, however, was not the end of the story. On July 10, only a few weeks after the project was opened, a 14-ton slab of concrete fell down from the roof of one of the Big Dig's tunnels onto a car, killing Costa Rican immigrant Milena Del Valle and injuring her Puerto Rican husband Ángel Del Valle. The scandals and recriminations that had all along plagued the highway project, with the cost overruns the most expensive in US history, reappeared with a vengeance. Vengeance as shown in the September 19 Massachusetts gubernatorial primary, in which newcomer Deval Patrick humiliated the state's Attorney General Thomas Reilly, who had earlier in the year appeared in public opinion polls to be the prohibitive favorite for the nomination. Reilly, whose campaign had taken more than $35,000 from people connected with Parsons Brinckerhoff and other Big Dig contractors, and who despite Inspector General reports detailing tens of millions of dollars worth of cheating by Parsons Brinckerhoff and its consortium partner had let the statute of limitations run out the state's legal ability to seek compensation, fell behind when the Del Valles were crushed. His aspirations for higher office were flattened when, two days before the election, the Boston Globe ran a story about how Parsons Brinckerhoff and Bechtel's corruption weakened the ceiling that fell in on the unfortunate couple. Reilly finished in a distant third place. The ceiling's designer, a company called Gannett Fleming, had recommended using four bolts to secure each ceiling hanger. But in a 1988 memo that the Boston Globe obtained, a Bechtel/Parsons Brinckerhoff manager insisted that "Unless I'm missing something, I don't see why [the ceiling designer] requires a 4 bolt anchor plate when a 2 bolt anchor plate would be sufficient." And how did Parsons Brinckerhoff and its partner "know" that only half as many bolts would suffice? Cutting costs on testing, they used the work of an obscure Portuguese institute that tried the bolts in pull tests conducted in solid rock --- even though the Big Dig bolts would be anchored in softer concrete --- using weights well below US industry standards. The ceiling designer caved in to Bechtel/Parsons Brinckerhoff's demands, the ceiling caved in on the Del Valles, and now a state grand jury is considering criminal charges and the FBI is conducting a federal investigation. And it does not look good that the Panama Canal Authority (ACP) used Parsons Brinckerhoff to do the controversial $5.25 billion cost estimate for the proposed Panama Canal expansion project, and moreover the authority signed Parsons Brinckerhoff to a 10-year consulting contract just a few days after the roof fell in on the Del Valles. The ACP and the "yes" campaign it leads have the advantage that these unseemly facts don't appear at all on the major television stations and just barely get mentioned on the opinion pages only of some of the dailies. However, for years the ACP avoided questions by Panamanian reporters by making their declarations to the foreign press, knowing that by way of the Internet their questionable press release claims would come back to Panama. Now they are finding that the international media can be a two-edged sword that can cut them as well, and that their almost total control of Panama's mainstream media has resulted in the proliferation of websites, radio shows and other novel communications media that exist precisely to be beyond such controls. Now the ACP is in denial and damage control mode. The problem is, its stories don't always match each other, and worse yet for them, sometimes don't match the information that they have published on their own website. The damage control operation began with emails from Edelman, a US-based company with a $998,000 contract for the ACP's English-language "yes" campaign public relations. Edelman told The Panama News that "Parsons Brinckerhoff - ACP has actually not signed any contracts with any firm for the actual expansion project. If majority of the Panamanian people says "yes" to expansion, then and only then will ACP begin the bidding process for expansion contracts. The ACP has worked with Parsons Brinckerhoff (along with several international firms), in parts of the planning process for the expansion master plan. But to be absolutely clear, no one has been signed for the actual expansion itself." Just like Edelman "refuted" a critical Council on Hemispheric Affairs report that centered on Panamanian government corruption as the main problem with the Torrijos - Alemán Zubieta Plan without actually mentioning the corruption issue, the publicists sidestepped the main point: Parsons Brinckerhoff, which managed a project that started off with a $2.6 billion price tag that has ended up costing more than $14.6 billion, is the author of a $5.25 billion cost estimate for the Panama Canal expansion that critics --- including former canal administrator Fernando Manfredo and former chief canal engineer Tomás Drohan --- say is flagrantly understated. Then the ACP's Third Locks Information Center issued a statement insisting that "the Parsons Brinckerhoff International firm has not done design or engineering work for the ACP. Its functions and contract are limited to assisting the ACP in the area of management and direction of studies.... As a matter of clarification, the ACP has contracted the PB Consult company, which is a subsidiary of Parsons Brinckerhoff International and thus the consultants assigned to the ACP are not involved in the so-called Big Dig project." This semantic dodge might sound slightly more convincing were the signature of a representative of "Parsons Brinckerhoff International" not found at the bottom of the third locks cost study published on the ACP website. Then, in an Internet exchange, ACP board of directors member Roberto Roy joined the fray. "First the ACP itself did its estimate. Then Parsons Brinckerhoff team did its." (Why, then, one cost estimate study document published on the ACP website instead of two? Roy didn't say.) "This company is not the other firm called PBS & J, which has recently been the subject of investigations related to project cost overruns and illegal contributions to electoral campaigns." Parsons Brinckerhoff may not be the only company disgraced by cost overruns on a mega-project --- but unfortunately for the ACP, its consultant is disgraced by the Big Dig, the biggest US highway boondoggle of them all. It may not be under investigation for illegal campaign contributions --- it's just a matter of its managers' and lawyers' and political action committees' legal contributions becoming the kiss of death for American politicians known to take them. The bottom line in the debate leading up to the October 22 referendum here is the bottom line --- is the $5.25 billion cost estimate credible, or is it not? Parsons Brinckerhoff's involvement in the formulation of that estimate becomes an issue not because Panamanian voters will be deciding whether or not it's a rogue company, but whether or not to believe the number it provided. Still, it does help to examine Parsons Brinckerhoff as a detective would assess a criminal, paying particular attention to modus operandi. The Massachusetts Inspector General, in a report about how Bechtel/Parsons Brinckerhoff helped politicians conceal huge Big Dig cost overruns from voters, said that "they did so by applying a largely semantic series of exclusions, deductions, and accounting assumptions...." And the "no" campaign, pointing to the exclusion of financing costs, the bridge or tunnel connecting Colon's Costa Abajo across the proposed new canal entrance to the rest of Panama, a lot of dredging work and other items from their estimate, claims that they're doing it again here. In a series of email exchanges apparently monitored by the ACP's campaign consultants, it was noted that on page 11 of the ACP-published PDF document whose heading was shown above --- the signature page --- the Parsons Brinckerhoff representative signed in the name of "Parsons Brinckerhoff International." Then, all of a sudden, there was no page 11 to this document on the ACP website anymore. Alas, they left this , title page up, from which The Panama News copied the above excerpt. Also in this section:
News |
Travel Make the
Executive Hotel your headquarters in Panama City --- http://ww.executivehotel-panama.com Find the boat of your dreams through Evermarine --- http://www.evermarine.com |


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Jose Mourinho pledges to stay on
MADRID -- Jose Mourinho pledged to remain at Real Madrid despite failing to reach the Champions League final for the second straight season Wednesday.
"If the club and the players want me to continue, I will," Mourinho, whose deal runs to 2014, said after Madrid bowed out 3-1 on penalties to Bayern Munich after the two-legged series closed 3-3 on aggregate.
Chelsea eliminated defending champion Barcelona on Tuesday, and Mourinho wished his former club luck ahead of the May 19 finale at Bayern's Allianz Arena.
"I obviously want Chelsea to win, they were heroes to beat Barcelona with 10 men," the former Chelsea manager said from the Santiago Bernabeu stadium. "I'm proud of my players and we have to be strong but we were lacking freshness in an enormous game."
Chelsea rallied from 2-0 down with 10-men to draw 2-2 at the Camp Nou and eliminate the Spanish champions.
Much of the Spanish media and some of Barcelona's players labeled Chelsea's performance "anti-football" as it sat back to defend and look to score on the break, just as Mourinho's Inter Milan did to beat Barcelona in the semifinals on course to the 2010 title.
Mourinho said those who criticized the Blues performance "knew nothing."
"Some people think they are the masters of the game and they will criticize Chelsea the way they criticized Inter two years ago. But they know nothing," Mourinho said. "They know nothing about character, they know nothing about effort, they know nothing how it is to resist with 10 men. I have my heroes at Inter, I have my heroes at Chelsea."
Mourinho was quick to defend Cristiano Ronaldo and Kaka -- former world players of the year -- for penalty misses by pointing to Barcelona star Lionel Messi's miss against Chelsea.
"It saddens me that you want people to forget that Messi missed a key penalty and point out that three players missed penalties today," he said.
Madrid now turns to at least taking the league title from Barcelona after three seasons as runner-up, which is at least an improvement from last season when it managed only a Copa del Rey trophy. Madrid leads Barcelona by seven points with four games to play.
"I'm super proud of them. It's difficult for a team to reach the semifinals in two straight years and for a coach to reach six in eight years," Mourinho, a two-time Champions League winner, said. "We deserved to win."
Copyright 2012 by The Associated Press
Soccer on ESPN.com
Coverage on ESPN FC
- Bennett: Great American swindle?
- Marcotti: Robin van Persie's future
- Cox: Under the radar
- Jose Mourinho exclusive interview
- State of Scottish football
- Marcotti: Preseason's double-edged sword
- MLS Power Rankings, week 20
- Bennett: EPL crisis?
- MLS second-half stories to follow
- Marcotti: Di Matteo's vision for Chelsea
- Can the NASL contain the Cosmos?


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iWikiPhone.com's newest release, Trackdance, is hoping to be all the rage at your next college party.
"Trackdance allows your iPhone/iPod screen to display spectacular digital light shows to the beat of your music or music around you. You can also connect as many iPhones together as you like so the effect will appear over them all — great for nights out, concerts, and also most especially house parties."
The idea, which came from an American teenager, is quite neat, but could do more with the implementation. There are 3 effects in Trackdance, of which one, the text scroll, is really cool. The other two are a fireworks show and flashing lights said to match the beat, but in the videos they look fairly random.
Check it out yourself in the video below, and if you get it, make sure that you are with the right crowd before busting it out in a party. Remember… there have to be a bunch of iPhone's to make it cool.
Released: 2010-07-29 :: Category: Music
Tagged with: iWikiPhone, Trackdance


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I am trying to build my water for a Black IPA. It's going to be very high in IBU (about 100). Grain bill will be fairly straightforward (15.5# of 2-row, 1# of Crystal 60, 1# of Carafa III). SRM estimate is 38. Here is my water profile Ca 56 Mg 26 Na 23 Cl 10 So4 9 (adjusted because it is SO4-s) HCO3 302 I have been using the spreadsheet put together by -TH- to determine how to treat my water. I'll be using 6 gallons of mash water with a dilution of 2:1 distilled:my tap water (67% for purposes of the spreadsheet). I do this primarily to cut the alkalinity of my water and reduce my RA. The precision on my pH meter is only .1, however, I have noticed that my pH readings are generally pretty close to what the sheet estimates. With this dilution and no other mineral additions, the spreadsheet anticipates a mash pH of 5.03. However, it still puts my RA at 63 and my Ca, SO4 and Mg are all below the recommended ranges for brewing. If I add Gypsum, CaCl, and perhaps a tiny amount of Epsom salt in order to bring my RA down and move my minerals into acceptable ranges, that works, but it further drives down my already low mash pH. I have also tried looking at a smaller dilution% of distilled, but while that helps raise the estimated pH a bit, I have to add a large amount of minerals to bring my RA in line. This in turn starts to throw my ppm measurements on the various minerals out of whack (and again starts bringing the pH fairly low). I seem to have this thing on a scale that I can't balance. I tip too far one way and it throws the other out of whack. I can either get mash pH into the 5.2-5.5 range or bring RA below 50. But I am having trouble doing both. I have thought about one of the pH raising mineral additions and it only serves to drag RA with it. At this point, my only other option is to reduce the amount of either crystal or carafa and bring the SRM down and the pH up a bit. Any ideas?
I just tried the last part. I took the crystal and carafa to 3/4# each and replaced that with a half pound of 2 row. It changes the SRM to 32. Plugged into the spreadsheet with the 67% dilution and an addition of 4 g gypsum, 2 g cacl and 1 g epsom yields a mash pH of 5.08 (still a touch low) with an RA of 15. Better. What do you think?
It is possible to adjust pH without significantly altering your ion profile. I've always done this using analytical grade (i.e. food grade) potassium hydroxide, or if not available, analytical grade sodium hydroxide. Adjust your waters ionic makeup, then adjust the pH to the desired pH using KOH/NaOH. Both KOH and NaOH are highly caustic, so handle with care. I work in a lab, so I have no idea what the availability of these products are in the real world. None-the-less, you cannot be the first brewer whose had this issue, and I'd be highly doubtful if a strong base of some sort was not available for the purpose of adjusting pH. Bryan
Lab grade KOH and NaOH are easy to get, check out essential depot. I use lactic acid as sauermalz to adjust pH down and chalk in the past to adjust it up. I intend to use KOH in the future but since making that decisions I am through a dozen batches with no need to raise pH.
The ONLY thing that matters is mash pH. RA provides a rough guess of what the mash pH will do with a straight pale malt grist. You cannot rely on RA to predict your mash pH since some grains have differing levels of acidity and the resulting mash pH can be all over the place eventhough the beer color says it should be OK. Forget about RA and aim for a proper mash pH and your beer will be better. The lowest mash pH you should think about aiming for is 5.2 and I suggest that even that is too low. The optimum mash pH range is 5.3 to 5.5. You can learn more about mashing water chemistry and how to properly adjust it by downloading and reading Bru'n Water at the link in my signature line.
Martin B Carmel, IN BJCP National Foam Blowers of Indiana (FBI) Brewing Water Information at:https://sites.google.com/site/brunwater/ Like Bru'n Water on Facebook for occasional discussions on brewing water and Bru'n Water
Its not nonsense, its just that it can't be well correlated to beer color as was attempted in the past. RA is still very valid, it just isn't a good predictor for mash pH under some conditions.
RA is excellent for its intended purpose: comparing water supplies. It has been turned into nonsense by some in the HB community who have assayed to hang the entire design of mash/beer on it. It wasn't intended for that and it isn't very good for that. One of the most interesting aspects of it is that its oft cited correlation with mash pH is not what Kolbach described. He spoke of a correlation with wort knockout pH. Now that, of course, correlates with mash pH and so there is a correlation between mash pH and RA but it isn't probably very tight (low Pearson's r).
I have been working to get both the RA in line and the mash pH in the 5.2-5.4 range for a couple of reasons: 1. In many of my discussions with ajdelange here, my RA was at issue, primarily because the water I begin with is so highly alkaline. Per the report from ward labs, my bicarbonate comes in at 302 with a total alkalinity of 247. 2. Although it was brought into question a couple of posts above this, I did recently read an article in BYO (I can pull the exact issue when I get back to my house if needed) where the writer says that for basic brewing water, you should try to bring your RA down to 50 or lower for most styles. Much of the confusion I have right now stems from using the spreadsheet built by -TH- any available in this forum. When I add the grains, my base water and enter the predicted SRM for this beer in his sheet, I get a predicted mash pH of 5.27, but an RA of 192. That's with no mineral additions and no dilution with RO water If I add minerals or dilute my water to bring the RA down, it pushes my mash pH below 5.2. I once asked aj what I would expect with a high RA; how I would know that any flavor contributions to a beer were from alkaline water. He told me to dissolve a small amount of baking soda in a glass of water and taste it and see how I liked the flavor. I was not happy with the results of that test. So I find myself back at my original question, which is going to be the most important for this beer? The recipe as it stands alone with my house water will be in the right pH range (just over 5.2) with an RA of nearly 200. If I dilute my mash water with 50% distilled and add 3g each of Gypsum and CaCl, the sheet shows that I should expect an RA of 49, but that my expected mash pH would be 5.12. Not to muddle the argument any further, but I am running into the same problem with a stout recipe I have on deck after this Black IPA. I can either get the RA in range and the mash pH lower than 5.2, or I can get the mash pH in the 5.2-5.4 range and the RA will be over 150
The advice to keep RA below 50 in most cases is good advice. It is seldom that alkalinity brings anything to the party. The only exception to this would be where a lot of dark malt is being used and pH is at or below the low end of acceptable. It has been my experience that one can make some very dark beers with water with an RA of 50 or less without going too low but that assumes that the dark/roast malts are in what are, to my taste, reasonable proportion. If you are using dark malts beyond this point then there is the possibility of low mash pH. You usually want to compensate for this by adding some alkali (chalk, lime) to the mash as opposed to trying to increase the RA of the water. Under no circumstances should you accept an indication that RA needs to be set at a given level based or beer color nor should you pay any attention to a change in SRM based on a mineral addition or dilution that changes RA. The connection between beer color and SRM is tenuous. The best thing for you to do here, IMO, is prepare RO/DI water with 1/2 - 1 tsp calcium chloride per 5 gal. This will give you very low alkalinity and negative RA. Swap gypsum for half the calcium chloride if you want assertive hops (which it appears you do). Mash in and check mash pH. If it is too low, add some chalk or picking lime. There is a good chance that mash pH will not be too low. It really depends on the base malt and the particular colored malts.


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GG Migy
Junior Member
Hi so i keep getting this error when i try to update the new draven patch!! fuuuu! I haven't changed anything before this happened so i don't know what 2 do next? it stops at 99% and 33% on the Draven_splash-1.jpg, iv looked around on other forums and help links but nothing helped so if any1 can please help me get this working you will be a legend!!! oh and iv done the following - restarted - run as admin - waited a day and tried again and again - deleted the lol_launcher folder - turned off peer 2 peer, antivirus
mugiwara bøy
may we have the same problem http://euw.leagueoflegends.com/board...d.php?t=723100
i feel your pain... well i hope some1 knows how to fix this cause it seems theres alot of people who have the same problem as us
Hi i have exactly the same problem, can someone pleas help us?
g the mastermind
Senior Member
me 2 :+
same problem here
"Greetings Miguel, I'm sorry to hear that you're having trouble with your game client. This problem is most often caused by a failed self-patch of the patcher. Although we are working to resolve this issue there are a few known workarounds. The first and most common solution is to force the patcher to repatch itself. You can do this by deleting this folder: C:\Riot Games\League of Legends\RADS\projects\lol_launcher If you chose a custom install path, the folder may be in a different location. Many players also fixed this problem by disabling the UAC(Windows Vista and Win7 Only) Here is a short guide to disabling the UAC: http://www.howtogeek.com/howto/windo...windows-vista/ * Be sure to use the "Never notify me when:" setting Other less common solutions include: - Manually Updating/Installing the .Net Framework 3.5 http://www.microsoft.com/downloads/e...displaylang=en - Making sure you are running the game as an administrator. a) Right-Click on the short-cut b) Select the properties tab c) Check the box labeled "Run as administrator" If the problem persists or you have any further questions feel free to contact me again. Please include your kernel and launcher logs in your response: Log information: http://support.leagueoflegends.com/entries/20076987 Best regards, Tamfail Player Support Specialist" thats what old riot had to say, hope it helps you guys...
same problem plz help me
i have the same problem plz help us
1ST SOLUTION! okay iv finally got it working!, i asked a friend 2 download lol on his pc and updated it there, then i just copied it straight to my pc and it works again... try it!