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So I read "Deliver Us from Evie." I wouldn't really recommend it. It was kind of below my reading level not to insult anyone who has read it and liked it. It just wasn't very fast-paced. It also didn't have that great of a plot. It didn't have that much lesbian content. Not that I wanted it to have adult content. I just wanted the main character to be a lesbian instead of her being more of a supporting character.
hum well a good book-by me i think-that is more...adult, to me at least considering the teen based novels i usally read is Price of Salt, about one girl whos in a bad marrage and one who hates her job and they meet and go on a roadtrip and fall in love and the womens husband gets jealous-thats all im saying for that matter-it was slow but for some unknown reason it was also really good-one of those ones i kept thinking about-even tho the ending was sort of confusing.
Come Josephine in my flying machine
Going up she goes up she goes
Balance yourself like a bird on a beam
In the air she goes there she goes
Up, up, a little bit higher
Oh, my, the moon is on fire


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"The primary factor in the success of digital pathology is the pathologists and the pathology support, not the technology," said Steve Potts. "How well are they able to work side-by-side with image analysis scientists, how well are they supported by IT in hosting and sharing data through firewalls, how quickly do they embrace the use of the computer screen for daily work? I am proud to join two visionary pathologists in helping drive this technology forward. David Young's most recent work with EMT biomarkers and clinical companion diagnostics at OSI Pharmaceuticals, and Frank Voelker's long track record of image analysis innovation are remarkable examples of the potential for this technology, provided that it is led by pathologists. Rather than a few IHC tests run thousands of times in a clinical environment, drug and device development require almost each study to have a new image analysis technique applied by a pathologist. Flagship has a remarkable combination of pathologist and image analysis experts, working side-by-side and delivering results quickly and cost-effectively."
Flagship Biosciences is a pathologist-owned company whose mission is to improve tissue assessment in pharmaceutical and medical device development. Flagship's services include quantitative pathology assessment on-demand, low-cost
Source: PRWeb Copyright©2010 Vocus, Inc. All rights reserved |

subset: commoncrawl


text:
Tue, 24/02/2015 - 19:14
New regulations are allowing hedge fund managers and institutional investors to take advantage of fresh opportunities in the Swiss market, from innovative new fund platforms to new fund strategies and structures that provide significant portfolio diversification opportunities... »
Tue, 10/02/2015 - 13:49
Global gross domestic product (GDP) growth should accelerate somewhat in 2015 and 2016 from the pace of the last three years because of much lower oil prices, the avoidance of special drags on the world economy, and continuing easy monetary policies from global central banks, according to BNY Mellon Chief Economist Richard Hoey. Hoey (pictured) made the comments in his February outlook. ... »
Tue, 03/03/2015 - 13:16
Nominations for the 3rd edition of the Wealth Adviser Awards, which recognise excellence among wealth managers and service providers including trust companies, law and accounting firms, is now open. The Awards will be presented at a lunch ceremony in London. ... »
Tue, 20/01/2015 - 10:06
This Hedgeweek Special Report explains not only why managed futures should be reconsidered by investors, but also how a more effective risk allocation strategy can benefit investor portfolios in both correlated and non-correlated markets... »
Tue, 03/02/2015 - 12:05
Following recent dips in the Euro, Jeff Keen, fund manager at Waverton Investment Management, offers his view on why it will rebound… ... »
Thu, 05 Mar 2015 00:00:00 GMT
Financial Model Development ManagaerThu, 05 Mar 2015 00:00:00 GMT
Senior C# Web Developer 200-300KThu, 05 Mar 2015 00:00:00 GMT


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Found the same room at a different price? Tell us, and we'll offer to match it.
Reviews - WILLOW GUEST HOUSE
Self Classified Budget Hotel | Ratings explained |
This is a family run Guest House situated in the city centre of Glasgow and close to most amenities.
Glasgow airport is approx. 10 miles away with Glasgow Central Train station and Buchanan Bus station a short Taxi journey to the Guest House.
Street parking only with vouchers supplied at reception ( £2 for 6hrs.£4 for 12hrs or £6 for 24hrs.)
All rooms are en-suite and rate includes full breakfast and all taxes.
Reviews can only be left by customers of LateRooms who have booked and stayed at this property. All reviews are left in accordance with our conditions of posting. All reviews posted are the opinions of people who have stayed at this accommodation, not of LateRooms.com. These opinions may vary greatly and should be considered alongside all the other information available for this property. If you have more questions regarding our guest reviews read our FAQS. Terms and Conditions of Hotel ReviewsOnly the opinions of a person, or people, who have actually stayed at the hotel(s) concerned may be submitted. You must accept all liability for the contents of all postings made by you, or on your behalf. Please be aware that the hotel which you review will receive a preview of your comments 2 days prior to them appearing on the website. The hotelier may request your booking reference number in order to address your comments. In some circumstances this may affect your anonymity, but only with regard to the hotel you are reviewing. Your review may be withheld for up to fourteen days, while LateRooms.com vet all comments for posting. We will review all submissions for basic profanities and vulgar language, and we reserve the right to remove (or not publish) comments at our discretion. We also reserve the right to identify you in response to a court order, threat of legal action or complaint. If you believe that there is a review on LateRooms.com that should be removed due to the fact that it may offend or be illegal, please let us know and we will investigate and take action if appropriate. Please be advised that any review that you post on LateRooms.com will be shared across all websites operated by LateRooms Ltd including miniBreaks.com and may be distributed to selected LateRooms.com partner websites. Please be aware the name and location you choose in the reviews form will be displayed alongside your review. You may not use, or allow others to use, your review questionnaire to: Complaints If you wish to complain about, or have any concerns about any review left by others on the site, please contact email@example.com. |


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Posts: 1,182
Joined 23-Apr-12
Posts: 1,967
Joined 4-Feb-10
It sure is.Timing is the least important factor and there's lots of successful sways posted where they've entirely disregaded timing.
(2010)... #2 Due July 3, 2013
Posts: 140
Joined 10-Mar-12
LTB-JAY - So cool. I'm actually in Aurora (just north of Toronto) but no one knows where that is LOL (maybe you do!!). Certainly keeping sperm count low is important. Good luck! Are you talking about the pic in the sidebar (go to my profile/avatar and upload your own pic) or the signature (go to my profile/signature and do your thing in the box below)???
PetiteFille - I personally don't believe that, I conceived my DD when I was 27 and I wasn't swaying or anything. I say if the other sway factors are in play, that's more important. Good luck :)
Posts: 451
Joined 4-Apr-11
'07'10~Expecting Twins in April! 1 and 1 in there!!I I make it full term!
Posts: 475
Joined 5-Jun-11
in regards to my sway, I did 6 sway factors and timing wasnt something I focused on. although I didnt DTD on ovulation I didnt do frequent release or long abstinence and still got my desired gender.
I believe Diet and Ph are the most important factors but if you can include timing in your sway this may up your chances as well!
2008, 2010 , 2012 - Swayed with Girl Diet
My beautiful family is complete!
You have to test your cm with strips or a digital tester to know what's working and what isn't. I found that some of the supplements raised my ph.
Yes, it's best to use the digi smileys since they are the most accurate. But temping is also important too. Here's what I found that really simplifies O+12...
The exact timing of 0+12 is way easier than trying to find O. 12 hours after you O your cervix will go from soft to hard and your cm from ew to creamy or from creamy to dry. If you can't find this you need to track your temps for 3 cycles to see when you O after a +opk (your temp goes up the morning after O. Then do your attempt the night before your temp spike.
Here's a bit about temping...
The temperature rise definitely happens AFTER ovulation, not before. It's also unlikely that ovulation in the middle of the night would result in your progesterone kicking in so fast as to raise your temperature within the few hours before you take your temp.
Most postinest poster
Posts: 38,103
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Gold Membership
I do not think anyone ttc a girl should be on o day unless there body chemistry has shifted in o+12 zone


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Myrian Johnson
AA&E: Where the money is, if anywhere, in military freight
FedEx custom-critical expediters Andy and Myrian Johnson are sunny about high-security military freight, where the money is -- if it's anywhere -- in the niche.
A bone to the industry from an agency in the doghouse
Boosting the low-use mileage exemption just won't be enough for some operators with CARB-noncompliant engines. For others, it doesn't change their thoughts on the agency's emissions regs.


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Showing recordings 1-10 of 14 that were created in 2011 for the song "Downtown" by Emma Bunton. The recordings are sorted by date. Click the year links to view recordings for a different year or the page links further down to view more recordings for the currently selected year.
By maltashelly in the Style of Emma Bunton
106 views 3 comments 3
Video Recorded
A great oldie h1{display:none;}


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tive to policies that take meaningful action but require additional costs. The determinants of concern are likely to vary with the environmental problem, the country, and characteristics of the individual, so the research should be comparative between countries and environmental problems of different kinds.
One of the most likely consequences of global change will be effects on the prices of important commodities and factors of economic production in local and world markets. As a result, uncoordinated human responses will be affected greatly by markets. According to economic theory, producers and consumers respond to changing relative incomes, prices, and external constraints, so that, if the market signals are allowed to reach individuals and market prices include all the social costs and benefits of individual actions, the responses will be relatively rapid and efficient.
Markets allow for many forms of uncoordinated adjustment, as the example of climate change illustrates. People may rapidly alter patterns of consumption (e.g., substitution of water skiing for snow skiing) and production (e.g., relying on snowmaking equipment rather than natural snowfall). Over the longer run, societies may respond, in the case of unfavorable climatic developments, with the migration of capital and labor to areas of more hospitable climates. Structures tend to retreat from the advancing sea, people tend to migrate from unpleasant climates, and agricultural, sylvan, and industrial capital tend to migrate away from lands that lose their comparative advantage. In addition, technology may change, particularly in climate-sensitive sectors such as agriculture and building.
However, the conditions that economic theory specifies for efficient adjustment are not generally met in the case of the global environment (Baumol and Oates, 1988). In three important respects, existing markets do not provide the right signals (in the form of prices and incomes) of social scarcities and values. And in addition, as already noted, the participants in markets do not always behave as strict rules of economic rationality predict.
Environmental externalities of economic activity, that is, effects experienced by those not directly involved in economic transactions, are not priced in markets today. Someone who emits a ton of carbon into the atmosphere may produce great damage to the future climate but does not pay for the damage: effects that


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sent from: London, UK. destination: Los Angeles, California, USA |
In case you have been living under a rock, Disney bought Lucas Film (including ILM) for 4.05B $. Below, is speculation on what this means to ILM's production and future.
From Juan-Luis Blog:
FULL DISCLOSURE: what follows is pure speculation on my part and is not based on any inside knowledge that I have; it is purely educated guesswork.
What I will think will happen at ILM/Lucasfilm Animation, specifically where Star Wars is concerned:
- Lucasfilm Animation will be re-branded under the Walt Disney Animation banner, and subsequent seasons of The Clone Wars animated show will be produced in Singapore as they are presently.
- The hush-hush fairies/rockabilly CG feature that Lucasfilm Animation have been on/off with over the past 6 years will either be shut down or get a quiet DVD release under the Walt Disney banner.
- ILM will continue to serve external clients as they always have done, with an increasing reliance on satellite offices around the world in major production centres.
- Star Wars VII visual effects will be centered in San Francisco with a small core team, with the majority of the work produced at ILM Singapore and by a network of tightly controlled 3rd-party vendors all over the world.


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Got a fun, crazy life? Show your humor with this product. Features the saying
I don't suffer from insanity. I enjoy every minute of it.
Makes a great gift for any Scout who is crazy about Scouting.
This is a youth t-shirt. It is available in black or navy blue.


text:
Useful links featuring Eagle's Nest
To read what we say in our brochure, click on the link to download the brochure section including Eagle's Nest. To save a copy onto your computer, right-click on the link and select 'Save Target as...'.
We want you to understand more about Eagle's Nest. We're not shy to direct you to their own website as we're confident that a trip there with us will cost you the same or less than booking it any other way, even directly. So follow the links below for more information.
Eagle's Nest
A small website with basic information on this lodge.


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In December 2007, Alfaro set up another grow house in Delray Beach, according to PBSO documents, which also indicate the DEA had been seeking an indictment against Alfaro for the Parkland grow houses since at least October. And he seemed to be daring law enforcement to pin him down. Friends who'd known him for years said his personality had taken a dark turn. The high-spirited boy had morphed into something more ominous: He openly threatened violence to anyone who might be planning on "ratting him out."
Courtney was fed up with him too, and frightened. Alfaro had beaten her, she told Oliver, and she'd finally left him. Now she was willing to talk: He owned a .45-caliber Glock handgun. He'd once described a theoretical murder plan: If he ever killed Febonio, he'd chop up his friend's body and scatter the parts all over the city.
Oliver tracked Alfaro to the Delray grow house in May 2008. At the same time, the Delray Beach narcotics division was planning a raid on the house based on an informant's tip. But when Oliver and Delray cops showed up, Alfaro had fled again — evidently warned that the cops were closing in. When Oliver and the police arrived, all they found were stray pieces of equipment — rows of black buckets, empty boxes that had once held lights. And that telltale sweet-acrid smell.
Meanwhile, Alfaro flew to Maine. He spent time in Canada. Then, in the fall of 2008, he headed back to Florida and started yet another grow house, this time scaled down to fit in the condo he'd rented in a gated complex in Deerfield Beach, according to court documents. He also had a couple of new aliases: Julian Kane and Philip Durante. In Durante's name, using a fake ID and fraudulent credit, he'd bought a new white Infiniti for $32,000.
Coconut Creek Police stopped Alfaro's Infiniti for a traffic infraction the night of October 30 and found a sheaf of false IDs. At the station, Alfaro confessed to stealing the identity of Philip Durante, a childhood friend. He sneered at how easy it had been to get a fake driver's license at the bureau, boasting, "The bitch didn't even ask for ID when I told her I lost my license." Cops got a sample of Alfaro's DNA off a bag of peanuts he'd been tipping into his mouth. They found Canadian currency in his car. They turned up credit cards in the name of his aliases. And they found out he already had an active warrant for his arrest from the Broward Sheriff's Office for grand theft auto.
Oliver had a chance to interview Alfaro briefly, hoping to learn more about the murder, but Alfaro responded he "had nothing to say." He did tell Oliver the detective's "vendetta" against him had "cost him about $100,000." As he was being transported to jail, according to Coconut Creek Police records, Alfaro taunted the cops again and again, regaling them with the details of his grow houses. Broward Sheriff's Office records say BSO went over and picked up the eight pounds of pot and ten marijuana plants in Alfaro's condo. Coconut Creek Police charged him with fraud, larceny, and grand theft auto.
But the pattern held: Authorities didn't have the muscle to hold him. A friend paid Alfaro's bond, and he was a free man again.
It wasn't until five months later, on March 6, 2009, when Oliver finally got a break. The FBI had called with a lead. A man named Zayd Awadallah claimed he knew that Alfaro had killed Febonio. Awadallah had told the FBI that Febonio wanted to get out of his partnership at the grow house. Febonio was insisting that Alfaro pay him $10,000 for the construction work he had done.
Awadallah told Oliver that he was talking in hopes the cops would go easy on him for a Broward County cocaine trafficking charge. Alfaro, he said, had confessed he'd shot Febonio in the back of the head and stuffed his body into a General Electric freezer he'd bought at a BrandsMart in Deerfield Beach. The freezer, Awadallah said, had been kept at a house in Boca Raton. Awadallah said several people had seen the body in the freezer. The house had been burglarized, and when thieves opened the freezer, they found Febonio's corpse and fled, leaving the door open. When the homeowners and friends returned, they too had gotten an eyeful.
Alfaro was in Maine when he heard about the burglary, Awadallah said. Alfaro flew home in a hurry to move the freezer, with its 200-pound contents, yet again.
Five days later, the FBI learned that Alfaro had boarded a plane in Fort Lauderdale bound for Costa Rica. They called to tell Oliver that customs agents in Costa Rica had refused him entry and sent him back to the States. But sensing his luck was running out in Florida, Alfaro was preparing to flee the state.
Court documents claim Alfaro had either confessed to or hinted at the murder to at least a half-dozen friends and girlfriends. One of those ex-girlfriends, Alisa Catoggio, was to become one of Oliver's best sources. She told Oliver that after she posted Alfaro's bond in Coconut Creek, as they were driving to Marco Island, Alfaro not only admitted killing Febonio but also told her the gruesome details. Alfaro had driven Febonio to a construction site where he'd laid down a piece of black tarp in preparation for the murder. He'd told his friend he needed help getting supplies. While Febonio had his back turned in a corner of the garage, Alfaro shot him once in the back of the head. He left Febonio's body there, covering him with drywall until the next day. Then he returned with the freezer. He wrapped Febonio's body in the plastic tarp, shoved it into the freezer, and belted it closed. And he'd hidden the gun in the white Infiniti that Coconut Creek cops had arrested him in a year later. Laughing, Alfaro bragged to Catoggio about how the stupid cops had never found the weapon.


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I thought I'd consolidate a few bikes into one post. We stock just about every type of bike you can think of and at the moment we have some pretty nice mountain bikes in stock. The Redline Monocog is a really great bike and what got me started riding dirt. I still wish I hadn't let that one go but it resides with a close friend who gives it its share of attention.
We recently acquired the Redline D610 that is great for the person wanting a similar bike in a geared platform. We took this one and made it a 1×9 with a 32t ring up front. I'm a big believer in the one-by setup for geared mountain bikes. With a wide cassette and an appropriate front ring you get a light and very capable bike that's great for all around riding or racing. The advent of clutched derailleurs make it even more compelling. In the absence of a clutch we opted for a bash guard and chain keeper setup up front.
The Specialized rounds it out. It is an XL frame and would make a great bike to get into the world of SS MTB.


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France, 2011, 107 Minute Running Time Additional Countries: Belgium Genre/Subjects: Comedy, DramaLanguage: French English Sub-Titles
Friday, June 22, 9:15pm CLICK HERE for a full J'adore Festival Pass! Based on an autobiographical novel by philosopher Éliette Abécassis, A Happy Event stars Louise Bourgoin as Barbara, a student unprepared for pregnancy and parenting. As she struggles to finish her PhD thesis, she starts a passionate relationship with Nicolas (Pio Marmaï) and decides to have a child. The film chronicles her pregnancy and their relationship as the "happy event" brings them closer but also threatens to tear them apart. Bourgoin gives a stunning performance as the hyper-sexual future mother, and Marmai is excellent as the patient, but ever increasingly frustrated, father-to-be.
DIRECTOR: Rémi Bezançon Principal Cast: Louise Bourgoin, Pio Marmaï
CLICK IMAGE for the Member Newsletter
CLICK IMAGE to Renew or JoinMembership Updates and Sign Up
CLICK IMAGE for Information
CLICK IMAGE for more information


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Contact Info
ARC Southwest - Family Medicine1807 Slaughter Ln, Suite 490
Austin, TX 78748
Phone: (512) 282-8967
Fax: (512) 406-7351
Year Joined ARC: 2011
Education: B.S. in Biology, The University of Illinois, Urbana, IL, 1993
Medical School: University of Illinois at Chicago College of Medicine,Chicago, IL, 1997
Residency Internship: Lutheran General Hospital, Park Ridge, IL, 2000
Certification: Board Certified in Family Medicine
Professional Positions and Honors: Dr. Johnson was the Associate Director of the Sports Medicine Fellowship Program at Lutheran General Hospital in 2001-2002, and was the Team Physician for several colleges, universities and high schools in Illinois prior to joining ARC. He is a member of the American Academy of Family Physicians and the American College of Sports Medicine.
Personal Summary: Dr. Johnson enjoys spending his free time with family and friends, reading, and also tries to spend as much time as possible outdoors. He is particularly partial to golf, running, basketball, hiking and tennis.


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Zinio Reader
This download is served from an external site
closeNOTICE: This link will open a connection to a third-party site. CNET cannot ensure the security of software that is hosted on external sites.
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Full user review
"Pure Rubbish!"
None at all
Used the older version to read magazines on my PC. Subscriptions ran out so I hadn't used in awhile. Zinio sent a coupon to cover renewal of an old subscription, but guess what? Then new reader they asked me to download does not work at all. I just get a blank black screen. I followed the given instructions to correct the problem, but still nothing. Use to be a great service, but now pure junk. I'm going back to buying on the newsstand!
Awesome when it works properly. Very very frustrating when it doesn't


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Happy Monday everyone! I am baffled by the drastic change in weather since my last post, but today there is snow EVERYWHERE! To keep your mind off the cold weather, give a little listen to some music by your fellow Butler students.
Last Thursday, the Help Heal Haiti chapter here at Butler hosted a benefit concert. There were so many talented musicians that performed, and it made me feel insufficient because I have no musical abilities. Sigh.
First to perform was Freshly Brewed. I blogged about Freshly Brewed last semester, but I am obsessed with them, so of course I have to mention them again. My friend Allie is in Freshly Brewed, so it is always an added bonus to see her sing! They were great as always, and after they performed, a few members from the a Cappella group performed solo. They performed a variety of covers and personal songs, and they were all beautiful!
A few more people performed and did an equally wonderful job, and then Out of the Dawg House performed. I also blogged about Out of the Dawg House last semester, and I am also obsessed with them. They were as spectacular as ever, and did a great job. They did this crazy good mash-up of old school rap songs, and I freaking loved it!
The final act of the evening was a band named Coyotes. They were the winners of Java Jams, which was a music contest held earlier in the year. They played some folky-kinda tunes, and they were so great! They were super high energy and their music was really good. According to my sources, they will be releasing an EP in the very near future, so I highly encourage you to check them out.
Freshly Brewed and Out of the Dawg House will also be having concerts before the year is over, and you better believe I will blog about that too.
P.S. I linked the Facebook pages for all three groups, so go and like the crap outta them!
Have a great rest of the week, and thanks for reading
"St. Louis" by Coyotes


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Wednesday, April 30, 2008
autumn in the spring
Last fall I began a hand weaving of the dried corn ready for harvest. Somehow the scale -- 55" across, full of detail -- daunted me and I never finished it. This spring, while beginning to make image files for the new jacquards, I decided to make use of the scale & detail of the jacquard loom and imagine the tapestry as I had meant to weave it by hand. The color was a challenge for the mill, reddish golden stalks, but the weaving arrived today and I am delighted. And the scale is majestic: 54" high x 80" across!
Tuesday, April 29, 2008
chicory, second version
To follow up on the last post about weaving this tapestry to get the correct color, I received the next strikeoff of Chicory the other day, and the color is much improved, though the weaves are not yet finalized. In the first version, the weaves had more dimension and the chicory flowers nearly popped off the ground.
The weave designer told me that she will continue working to get the depth in the weaves and the colors correct. This was woven on a warp with a brighter base set of colors.
Wednesday, April 23, 2008
new jacquards
I have been experimenting for some time with jacquard-woven "tapestries" in relation to my hand-woven work. The industry has a specific kind of warp setup known as "tapestry", which consists of a repeating combination of 6-12 colors which combine & re-combine optically to create a semblance of a color spectrum. Semblance is, of course, the operative word. It is both a frustration, in that the true color I want to see is often not possible, and a relief, in that I know that the color I work by hand with such control is inimitable and hence, worth the effort!
Here is the first serious attempt to make a jacquard woven version of a full-color tapestry: Chicory, which relates to my work of last year called Cornflowers.
The question is rather like that I always ask at our life-drawing class: do I want an exact likeness or do I want to learn something new? I.E., is the color good enough here, without reference to the original? Perhaps I will let you browse back through other postings to find the original, as I can't yet bear to see them side-by side, and yet I consider this image to be quite handsome in itself. More on this as it evolves -- revisions are in process as I write this.
Shown here: Chicory 1, 2008, 26" x 36". Copyright Laura Foster Nicholson
Friday, April 4, 2008
spring stones
I find that I am needing sharp spring green in my life right now: I have been waiting for it but it is cold out and things are slow to open. The fields of winter wheat are emerald green against leaden skies and rich wet brown earth, but that sharp yellow green is only here & there in a weeping willow budding out. By next week I will be satisfied, but today I am weaving it in among the grey & black stones on my warp.
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MEF2C-Directed Neurogenesis From Human Embryonic Stem Cells
Funding Type:
Comprehensive Grant
Grant Number:
Award Value:
Disease Focus:
Parkinson's Disease
Neurological Disorders
Neurological Disorders
Stem Cell Use:
Embryonic Stem Cell
Cell Line Generation:
Embryonic Stem Cell
Public Abstract:
Understanding differentiation of human embryonic stem cells (hESCs) provides insight into early human development and will help directing hESC differentiation for future cell-based therapies of Parkinson's disease, stroke and other neurodegenerative conditions.
The PI's laboratory was the first to clone and characterize the transcription factor MEF2C, a protein that can direct the orchestra of genes to produce a particular type of cell, in this case a nerve cell (or neuron). We have demonstrated that MEF2C directs the differentiation of mouse ES cells into neurons and suppresses glial fate. MEF2C also helps keep new nerve cells alive, which is very helpful for their successful transplantation. However, little is known about the role of MEF2C in human neurogenesis, that is, its ability to direct hESC differentiation into neuronal lineages such as dopaminergic neurons to treat Parkinson's disease and its therapeutic potential to promote the generation of nerve cells in stem cell transplantation experiments. The goal of this application is to fill these gaps.
The co-PI's laboratory has recently developed a unique procedure for the efficient differentiation of hESCs into a uniform population of neural precursor cells (NPCs), which are progenitor cells that develop from embryonic stem cells and can form different kinds of mature cells in the nervous system. Here, we will investigate if MEF2C can instruct hESC-derived NPCs to differentiate into nerve cells, including dopaminergic nerve cells for Parkinson's disease or other types of neurons that are lost after a stroke. Moreover, we will transplant hESC-NPCs engineered with MEF2C to try to treat animal models of stroke and Parkinson's disease. We will characterize known and novel MEF2C target genes to identify critical components in the MEF2C transcriptional network in the clinically relevant cell population of hESC-derived neural precursor cells (hESC-NPCs).
Specifically we will: 1) determine the function of MEF2C during in vitro neurogenesis (generation of new nerve cells) from hESC-NPCs; 2) investigate the therapeutic potential of MEF2C engineered hESC-NPCs in Parkinson's and stroke models; 3) determine the MEF2C DNA (gene) binding sites and perform a "network" analysis of MEF2C target genes in order to understand how MEF2C works in driving the formation of new nerve cells from hESCs.
Statement of Benefit to California:
Efficient and controlled neuronal differentiation from human embryonic stem cells (hESCs) is mandatory for developing future clinical cell-based therapies. Strategies to direct differentiation towards neuronal vs. glial fate are critical for the development of a uniform population of desired neuronal specificities (e.g., dopaminergic neurons for Parkinson's disease (PD)). Our laboratory was the first to clone and characterize the transcription factor MEF2C, the major isoform of MEF2 found in the developing brain. Based on our encouraging preliminary results that were obtained with mouse (m)ESC-derived and human fetal brain-derived neural precursors, we propose to investigate if MEF2C enhances neurogenesis from hESCs. In addition to neurogenic activity, we have shown that MEF2C exhibits an anti-apoptotic (that is, anti-death) effect and therefore increases cell survival. This dual function of MEF2C is extremely valuable for the purpose of transplantation of MEF2C-engineererd neural precursors. Additionally, we found MEF2 binding sites in the Nurr1 promoter region, which in the proper cell context, should enhance dopaminergic (DA) neuronal differentiation. We hypothesize that hESC-derived neural precursors engineered with MEF2C will selectively differentiate into neurons, which will be resistant to apoptotic death and not form tumors such as teratomas.
We believe that our proposed research will lead us to a better understanding of the role of MEF2C in hESC differentiation to neurons. These results will lead to novel and effective means to direct hESCs to become neurons and to resist cell death. This information will ultimately lead to novel, stem cell-based therapies to treat stroke and neurodegenerative diseases such as Parkinson's.
We also believe that an effective, straightforward, and broadly understandable way to describe the benefits to the citizens of the State of California that will flow from the stem cell research we propose to conduct is to couch the work in the familiar, everyday business concept of "Return on Investment." The novel therapies and reconstructions that will be developed and accomplished as a result of our research program and the many related programs that will follow will provide direct benefits to the health of California citizens. In addition, this program and its many complementary programs will generate potentially very large, tangible monetary benefits to the citizens of California. These financial benefits will derive directly from two sources. The first source will be the sale and licensing of the intellectual property rights that will accrue to the state and its citizens from this and the many other stem cell research programs that will be financed by CIRM. The second source will be the many different kinds of tax revenues that will be generated from the increased bio-science and bio-manufacturing businesses that will be attracted to California by the success of CIRM.
Progress Report:


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Forgiveness: Why it Matters
Podcast: Download (Duration: 52:13 — 59.8MB)
Writer Anne Lamott once said, "Not forgiving is like drinking rat poison and expecting the rat to die." The new year means a fresh start, and this hour we'll explore the virtue of forgiveness. We'll discuss why it can feel so good to hold a grudge, but how forgiveness makes us stronger–and how we can forgive the unforgivable.
- Robert Enright, founder of the International Forgiveness Institute, author of The Forgiving Life
- Brad Binau, Dean and professor of Pastoral Theology at Trinity Lutheran Seminary
- Pamela Taylor, Imam of Columbus Unity Mosque
- Thom Wendt, educator and founder of peer-led survivor support group


text: Due to server move at ibiblio and now as I understand .htaccess directives not being used by default the indymedia scotland website http://scotland.indymedia.org has been down since Friday evening. I did a fresh test install of dadaimc on another server which worked under temp url: http://scotland.imcscotland.org . But when I restored back up of existing site due to internal refs (which now understand should be altered before db restore) to old database not only was I not able to set up restored site just yet, Also with new install interacting with old database now original site db needs further know fixs be applied to restore. (alter paths where filesystem is by direct sql injection) This all prob fixable when I find time. Note to Harry: do not alter db on ibiblio without consulting me. In meantwhile posts can be made to imcuk: https://www5.indymedia.org.uk/ cheers Micah.


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I have carried a Beretta 21A for years, it is light and easy to conceal, but a little light on the power.
So I am considering carrying my Beretta 92. So how do you go about concealing this weapon.
My normal attire is jeans, t-shirts, so forth. During summer shorts, t-shirt.


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National Public Gardens Day Tour
Date: Friday May 9, 2014, at 2:30 pm
Location: Herb Garden, Getty Villa
Admission is free. An advanced timed-entry ticket is required.
Celebrate National Public Gardens Day with Getty Gardens Supervisor Michael Dehart, who leads a tour of the Getty Villa's herb garden with a focus on aromatherapy and the ancient uses of herbs. Meet at the Tour Meeting Place outside the Museum Entrance.


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Resting on Grace
Dr. R.C. Sproul comments in his commentary on Romans: "It is Christ's righteousness that justifies us. All we bring to the table is our trust in Him and His righteousness. If we add one ounce of our own righteousness ...Read More
Becoming Heirs of the Kingdom
Romans 5 and 7 further develop the role of the law in regard to justification and its purpose in intensifying sin. For now it is enough to note that faith and works of the law are opposed in justification because ...Read More
A Double Transfer
Martin Luther comments: "Righteousness is given through imputation without works, and … this takes place through the nonimputation of unrighteousness. It is the same thing, whether we say, 'to whom God imputes righteousness' or, 'to whom the Lord does not ...Read More
Counting Faith as Righteousness
A desire to obey God and do good in itself is not opposed to faith. The problem arises when we see our works as the basis upon which God declares us righteous. John Calvin comments, "It is not he, whom ...Read More
Not by Works
We'll consider the nature of justification and faith in more detail over the next few days. Today we note the significance of the opposition of doing and believing with regard to justification. Faith is something we exercise, but Paul does ...Read More
Upholding the Law by Faith
Calvin also writes that after justification "there is sanctification, by which our hearts are prepared to keep the law; it is indeed imperfectly done, but there is an aiming at the work." Sanctification follows justification, so justification upholds the law ...Read More
No Room for Boasting
In his commentary on Romans, Douglas J. Moo writes, "God's wrath is the inevitable and necessary reaction of absolute holiness to sin." The Lord must judge sinners, and we cannot endure this judgment, but Christ bears it in our place ...Read More
Justification by Grace through Faith
If justification were a meritorious reward that we earn because we have faith, we would have no assurance of peace with God. After all, our faith is not always strong, and until our glorification it is mixed with sin. No, ...Read More
Righteousness by Faith
John Calvin comments on today's passage, "We have now the principal point or the main hinge of the first part of the this Epistle—that we are justified by faith through the mercy of God alone." To truly know the gospel ...Read More
The Righteous Shall Live by Faith
In other lectures, Dr. R.C. Sproul has paraphrased today's passage as "the just shall live by trust." The mark of righteous people is that they believe the Lord, that they trust His promises and seek to grow in their ...Read More
Daily readings to encourage your heart and mind in the pursuit of God and his glory.Topics
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- Twentieth Century


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Mount Vernon Statement: the contradiction at the heart of this conservative fusion
First, their argument. The main nugget of "Constitutional conservatism" is that America needs to return to the "limited government based on the rule of law" ideals of the Founders, who "sought to secure national independence, provide for economic opportunity, establish true religious liberty and maintain a flourishing society of republican self-government."
In "recent decades," the statement continues "America's principles have been undermined and redefined in our culture, our universities, and our politics," while the ""selfevident [sic] truths of 1776 have been supplanted by the notion that no such truths exist." The signatories demand that the federal government respect Constitutional limits and apply the principle of limited government based on the rule of law to every proposal.
They round out their philosophy by arguing that these ideals, embodied in the "conservatism of the Declaration," connect with the natural law tradition. Without this natural morality, the free market cannot operate; but with too big a government, "moral self-government" fails. Thus the connection between libertarians and social conservatives.
Thomas Jefferson would scoff at the characterization of the Declaration as "conservative." American conservatives have always had a difficult ideological road to travel. They have to be conservative about the historically radical ideas of democracy, liberty, and individual rights. The result here is an odd reading of the Founders, federalism, and the Constitution.


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Say the Time
A newer version of Say the Time is available.
Or, Learn More About Say the TimeExcellent
Full user review
"It used to be a great program"
There is a time announcement every hour.
There is a time announcement every hour whether you want it or not. At two am it is still going and I have a plane to catch in a few hours. .
The program was hard to control before now it is impossible.
2 replies to this review
Hello. You can easily turn off spoken time announcements for any period of time you choose. To do so, right-click on your taskbar clock (to access the Say the Time menu) and choose Settings. In the Spoken Time tab, choose What to Say. Click the 'Snooze' option, and set the start and end times as you like. For example, you could choose to 'snooze' the time announcements between 10 PM and 7 AM. I hope this helps you.
I lost version 10 - over-written by 11, then they wanted paying again! Did that happen to you?
carassius (See my review.)


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Choose A Physician Specialty To Submit CV and Contact Us: General Medicine Our Community McCamey, Texas is a beautiful area with an interesting history. Learn more about our region and our growing community. Facility What better place to practice medicine than in a modern clean healthcare facility, in a pleasant area of the Southwest United States. Submit your CV by selecting an opportunity above or forward a copy to: Director of Physician Recruitment. Director of Physician Recruitment McCamey Hospital 2500 S. Hwy 305 McCamey, Texas 79752 (Phone) (Fax) |
2500 Hwy 305 S - McCamey, TX 79752 - 432-652-8626 |


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App Description
From the creators of the award-winning games Auditorium and Pulse: Volume One comes Fractal, a new ambient music puzzler experience. Combo, Chain, and Cascade your way through a pulsing technicolor dreamscape that reacts to your every move, while manipulating Fractals, creating Blooms, and expanding your consciousness at 130 BPM. On the surface it's a mere puzzle game, but as you dig deeper, untold dimensions of expression unfold. Intuitive but complex, challenging but not harsh, Fractal is a truly engaging experience.App Changes
February 16, 2012 Price Decrease: $0.99 -> FREE!
February 15, 2012 Initial Release


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Found the same room at a different price? Tell us, and we'll offer to match it.
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Distances are provided for guidance and are calculated 'as the crow flies'. For directions and actual distances by road, please refer to the hotel directions tab for the particular hotel.
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MahJong Suite 2012
Full user review
"Very Challenging Majhongg"
I like the games and challenge of this suite. There are 14+ pages of various layouts. So far, I have not found 1 layout that is really easy. I appreciate the challenge. It works well with no detectable bugs or flaws.
The biggest problem I have encountered is when updates are available. About half the time, after the update is installed, it requires reactivation with a license key. In my experience, the key given when purchased has not worked. I have to go to customer support for a new key to start using it again. I have not been able to figure out how to get the bar chart not to appear after ending the game and trying to play another or exit. It is just a tad irritating but not a show stopper.
This is a great game and I play it often. With exception of the one con which could possibly be my fault when downloading or installing, I have encountered no other problems and the customer support always responds quickly and 99% of the time the issue is resolved with the first inquiry. I would recommend the Tree Software Suites as they are all very well done.
1 reply to this review
Hi clarkbgm,
MahJong Suite Activation Codes are tested before being sent to our customers, so they are always correct. You just have to verify
that the MahJong Suite version you have installed corresponds to the Activation Code you are entering.
Regarding the MahJong Suite Statistics window: click on "Tools" - "Options" - "Advanced" and then "Dialog box" tab. On this section,
un-select the "Game Won" check box and confirm by clicking "OK".
Thank you for your review.


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Emergency Medical Form (one for the year)
Event Permission Form (fill out for every off-campus or overnight event)
S.W.A.A.G (Students With An Awesome God) is Light of the Hills High School Youth Ministry. We are students who strive to grow in faith with our Creator, grow in friendship with our brothers and sisters in Christ, and serve our schools and community!
High School Sunday Morning Bible Study
9:30 – 10:30 every Sunday
In September, we will experience Financial Peace University, to learn what God teaches about managing money. Taught by Stephanie Luther
In November, we will learn how to Join Jesus on His Mission.
Taught by Brian Morris.
All freshmen through seniors in high school are invited!
SWAAG Youth Group: Sunday afternoons,
2nd and 4th Sunday of the month.
2nd Sunday of the month – we meet in one of our homes.
4th Sunday of the month – we meet in the Youth Room in the Education Building
If you have any questions about any of the above High School Youth Ministry events, please contact Pastor Alan Sommer, (530) 677-9536


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Just submitted the CCW application. According to AZ DPS, it will be approx 75 days until I get my permit.
Took the course @ Scottsdale Gun Club. Class went smooth. Looking forward to being legal, as I have carried a few times in the past, mainly when we travel.
Been wanting to do it for over a year, glad I finally did it.


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Let's Swing
Budd Johnson Quintet
1. Serenade In Blue 3:36 2. I Only Have Eyes For You 4:30 3. Downtown Manhattan 7:45 4. Someone To Watch Over Me 3:40 5. Falling In Love With Love 2:56 6. Blues By Budd 9:56 7. Uptown Manhattan 6:16
This is a glorious statement from the middle period of the incredible 55-year career of Albert "Budd" Johnson (1910-1984). One of the earliest Texas tenors, straw boss of the Earl Hines Grand Terrace Orchestra, and pivotal swing-to-bop figure. Johnson was gaining renewed attention in the reed sections of the Quincy Jones and Gil Evans bands when he taped this loose blowing session that still manages to convey his skills as an organizer. The quintet features brother Keg Johnson's trombone in the front line and an impressive Tommy Flanagan/George Duvivier/Charlie Persip rhythm section. 1960 was a very good year for Johnson, who had only recently cut the great Four Brass Giants album for Riverside (now on OJC-209).
with Keg Johnson, Tommy Flanagan, George Duvivier, Charlie Persip
Find out more about Budd Johnson Quintet


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I like many others apparently can stream anything else fine but netflix at a decent rate.. I have a 60 meg connection. Netflix says they are investigating reports from many comcast customers about throttling.and left it at that with me. Is comcast doing anything on this issue? I've called customer support and always get the run around. I'm close to switching ISPs.
Yeah I already read that thread and didn't really feel confident anything was being done, especially with the way it was closed, as if someone wants the issue swept under the rug. I'm tired of waiting on hold for 30 minutes and getting the run around or being told I'm being transfered to another section of comcast only to hear a click and know I've been hung up on. This issue is real and needs to be fixed.
I am having the same frustrating issue. Tonight is movie night. Any word if Comcast is involved with resolving the Netflix connection?
01-15-2014 07:13 PM - edited 01-15-2014 07:13 PM
In other news, Comcast dropped 5 places on Netflix bandwidth ranking. Coming in at 14th out of 17.
And of course the recent net neutrality overturn in Comcast's favor:
I'm sure theres no chance Comcast is in some way responcible for all the Netflix slowdowns...
01-15-2014 07:40 PM - edited 01-15-2014 07:40 PM
Netflix needs to work on the netflix issue!
Netflix is responsible for providing & maintaining sufficient bandwidth capability from its CDN's, & thru its own contracted peering routes, so that its customers receive consistent streaming rates Even during peak usage evening hours. Netflix is apparently not doing that. If you bother to objectively investigate, its found that the so called throttling is being experienced by netflix customers at every ISP.
Netflix has an additional motivation behind this, but thats left for a different thread.
01-15-2014 09:00 PM - edited 01-15-2014 09:35 PM
nallen84 wrote:
And of course the recent net neutrality overturn in Comcast's favor:
The case wasn't about net neutrality. The case was about FCC claim of implied authority, & FCC's attempt to reverse engineer a basis for that claim. The court decision was that FCC doesn't have the authority to regulate Internet Providers as such.
01-15-2014 10:09 PM - edited 01-15-2014 10:13 PM
Correct me if I'm wrong, but TATA Communications is associated with Comcast, yes?
Heres my tracert results on Comcast and through VPN, going to the same Netflix CDN (streaming is much more reliable on said VPN):
Tracing route to ipv4_1.lagg0.c063.ord001.ix.nflxvideo.net [126.96.36.199] over a maximum of 30 hops:
1 <1 ms <1 ms <1 ms unknown [192.168.1.1]
2 10 ms 9 ms 11 ms c-69-136-7-1.hsd1.in.comcast.net [22.214.171.124]
3 8 ms 10 ms 8 ms te-0-7-0-7-sur01.peoria.il.chicago.comcast.net [184.108.40.206]
4 22 ms 20 ms 15 ms 22.214.171.124
5 16 ms 19 ms 18 ms he-3-14-0-0-cr01.350ecermak.il.ibone.comcast.net [18.104.22.168]
6 29 ms 29 ms 29 ms ix-2-2-1-0.tcore1.CT8-Chicago.as6453.net [220.127.116.11]
7 41 ms 43 ms 41 ms 18.104.22.168
8 57 ms 56 ms 57 ms ipv4_1.lagg0.c063.ord001.ix.nflxvideo.net [184.108.40.206]
Hops 6 and 7 are TATA Communication links.
Tracing route to ipv4_1.lagg0.c063.ord001.ix.nflxvideo.net [126.96.36.199]
over a maximum of 30 hops:
1 15 ms 15 ms 14 ms 10.128.1.1
2 * * * Request timed out.
3 31 ms 15 ms 15 ms ae2.er2.ord7.us.above.net [220.127.116.11]
4 16 ms 16 ms 16 ms zayo-ntt.ord7.above.net [188.8.131.52]
5 16 ms 18 ms 20 ms ae-8.r05.chcgil09.us.bb.gin.ntt.net [220.127.116.11]
6 22 ms 17 ms 16 ms ae-0.netflix.chcgil09.us.bb.gin.ntt.net [18.104.22.168]
7 17 ms 15 ms 14 ms ipv4_1.lagg0.c063.ord001.ix.nflxvideo.net [184.108.40.206]
I have yet to see any evidence that Comcast is actually working on the issue. Most all they are doing is deflecting the issue away from them when everything is pointing at them. They even locked the long thread on it, guess they didn't want anymore bad press about Comcast.
01-16-2014 12:54 PM - edited 01-16-2014 12:54 PM
banditsc wrote:
I have yet to see any evidence that Comcast is actually working on the issue. Most all they are doing is deflecting the issue away from them when everything is pointing at them. They even locked the long thread on it, guess they didn't want anymore bad press about Comcast.
We are aware of these threads and the concerns expressed here. We are actively engaged. It is sensitive and we can't really say more than that right now.
nallen84 wrote:
Correct me if I'm wrong, but TATA Communications is associated with Comcast, yes?
If you mean interconnected with, then yes. We are also interconnected with many other networks.
Does that mean we are going to see answers, results or at least get an update soon? I've dealt with this for 2 months and Netflix is the main reason I have comcast. I'm very close to switching ISPs. I'm willing to wait a little longer if progress is being made
Yeah, right now Comcast blames Netflix, and Netflix blames Comcast. At this point I don't really care whoes problem it is, I think the two need to work togeather to resolve the issue. Which I'm sure is not easy, as they not only have to work togeather, but are also competitors.
1st. Why some frustrate closed "Is comcast blocking netflix?" thread.
2nd. I've just plugged in my new ipv6 capable router and can say that when browser goes through ipv6 i have no problems streaming even during network congestion hours.
Regardless whose fault the situation is, Comcast and Netflix show absolutely no decency whowing the "it's not on my yard" attitude. As soon as I have alternative I'm dropping both. BTW, I know five households in Chicago area that in last two weeks cancelled Comcast or Netflix due to the issue discussed here.
There is definitely a big issue in Chicago right now. I have two co-workers with Comcast / Netflix and they are both having this issue as well. We live about 15 miles away from each other.
One of my co-wroker today contacted AT&T Uverse. None of us have plans to drop Netflix so Comcast better get this sorted out.
I live in Chicago too. My wife recently watched 7 seasons of Dr. Who in 2 weeks on Netflix and she didnt complain about it, however she definitely had longer loading times then I am used to seeing, including freezing at 25% several times. Gaming has been attrocious for me at all hours of the day/night. Speed tests will bounce all over with pings mostly around 11, but up to 50 on some tests. DL speeds primarily at 57, but drop to 20 on the occasions that the ping hits 50. The speedtest is always spiking up and down.
Ok, I'm in Albuquerque NM, and have been trying to figure out where the poor netflix resolution problem is. Until today I've had the 50Mbps plan. I've been using the Ookla Speedtest, the Speakeasy speed test, and the Netflix "Example Short 23.976" to monitor download speeds and streaming speeds. The first two testing programs confirmed better than 30Mbps for the last month which was the limit of my modem. The netflix program was always erratic with anywhere from 235kbps to 3000kbps download...but never higher. We decided to get DSL to compare. Today, I finally got my CenturyLink ADSL 1.5Mbps (just 1.5Mbps!) fully up and confimed at 1.56Mbps download. Then my wife and I watched "Law and Order" as usual and were shocked. We saw better resolution than we've had in 3 months with the 50Mbps
Comcast service! And, after it ramped up it was a steady higher definition. I've reduced my Comcast service to the 3Mbps plan to compare to that. My observations are that either Level 3, Comcast, or someone else is limiting the Netflix streaming that comes down my Comcast cable.
From someone that has Brighthouse and Comcast. I use Netflix with both. The problem is with Comcast. Brighthouse provides HD quality with no pauses. Comcast is terrible. Looks like Universal is pulling more garbage like the Weather Channel FTV fiasco. Even suggesting Streampix.
Wow, I just posted a thread asking about this just now. So Comcast has already started throttling Netflix now? Well, I guess I will have to switch to AT&T if this keeps up. I just cancelled my cable TV because it was just too expensive to keep a bundled package. I am paying for the faster internet service that is running 60+ dollars a month. I feel as a customer we are getting screwed if Comcast is doing this.
01-18-2014 11:14 PM - edited 01-18-2014 11:15 PM
ErnestNM, Have you been able to confirm that your connection is via Level 3? Here in Chicago we are being routed through a Tata link which is overloaded and apparently Comcast isn't upgrading it.
Apparently, this is a standard practice for them to extort more money from the networks:
kosh56, I have not. I only used the three programs I mentioned. I mentioned Level 3 because of what I read previously. I really don't care who is doing it as I pay for a Mbps service for all providers that can deliver. For the last year and one half that has been primarily Netflix. I just don't need the super speed anymore...mostly never did. We dropped DirecTV and started Netflix and have never regretted it. At 1/10 the cost and 50x the satisfaction we are happy. So, whoever gives us the best Netflix experience gets our money. We now have 3Mbps with Comcast and 1.5 Mbps with CenturyLink and the total bill is $20 less than before. Going forward Comcast should deliver twice the Netflix resolution. If it doesn't by the end of next month, we will likely drop the service. CenturyLink is due to upgrade this area up to 12Mbps in the next few months. But, even if they don't we are currently very satisfied with their cost at $50 less than before.
dj280 said "If you bother to objectively investigate, its found that the so called throttling is being experienced by netflix customers at every ISP"
dj280, This is not the case with respect to my new CenturyLink 1.5Mbps account. As I said in my previous post, all day yesterday I got better resolution with it than the previous 3 months with Comcast 50Mbps service. I now have the Comcast 3Mbps service that is Speedtesing to 7.49MBps....kudos to them. Now, maybe Centurylink will have the same issues when I get past the 30 day money back guarantee. I won't know until then. However, this whole issue has caused me to reassess my ISP expenditures and bandwidth useage. I don't game and the 1.5Mbps CenturyLink connection provides the same page download and refresh rates I am used to and higher netflix quality than the past 3 months with Comcast. In a few days, I will change the blueray player connection back to Comcast and see what we get. But, for now the CenturyLink connection streams Netflix fine.
I am experiencing the same issue for about the past week. We actually had a Comcast Internet outage that customer support and the level 2 modem support could not explain, to the point where we scheduled a service tech to come out and take a look. Next day I get a call from someone down the pipe saying "sorry, it was a problem on our end." Ever since: I cannot stream netflix at anything above what I would describe as ultra-poor quality. Amazon and HBO Go both come across in HD, but netflix is worse than SD.
I have spoken with both Netflix and Comcast now several times. I think I will find another ISP before I cancel with Netflix. Beyond frustrated. Given that I am getting a consistent 28 Mbps down and have no issue with any service other than Netflix and have spoken with them at length and in tremendous detail, I am left to believe that something is wrong on the Comcast end.
fusinski, You might want to try what I did. Drop the Comcast speed to the 3Mbps level and get a DSL ISP at 1.5-3.0Mbps or more. You may be able to reduce your total bill to less than before as I did. And, you can switch back and forth to see which one is better. I picked up CenturyLink at 1.5Mbps and we just finished watching "Star Trek: Nemesis" with at least 640x480 and possibly 720x640 definition. This is the second full day of high Neflix resolution. But, I can only have the Blu-ray connection to that line to get that definition. With my computer also attached and idle, it brought the resolution down below SD where the Comcast resolution has been for the past 3 months or so. But, at least with this arrangement I get consistent HD and $20 less than before. And, on Comcast, the web pages I regularly access appear to be nearly as quick to load. I've had much higher speed than I really needed for several years now.
Average speed in the USA is about 1.85.
I've only had comcast for a week and already frustrated with them. Not only does Netflix not work but I loose connection almost daily since I've had it. Luckily I haven't cancelled my previous ISP yet. Im not sure what they are doing but connection is slow, but when I do a speed test it doesn't show it. Im a Network Technician and they have got to be throttling no other explanation. I have to use my other ISP for netflix which works great. but as soon as I try it with comcast doesn't work. Spent hours doing tests. Its not a Netflix issue its a comcast issue
Can someone from Comcast let us know that this is being resolved or whether I should just switch isps if I want to watch Netflix? I'm about to just switch.
power_excell, Have you used the Netflix test program "Example Short 23.976"? Search for it at Netflix. Pick the 1st one as there are several and only the first one has realtime speed statistics on the screen. You can also get to a whole variety of other streaming statistics by pressing Shift+Alt+"Click on screen". That brings up a small diagnostic window with several selections.
Prior to 3 days ago, and for the last month with my previous 50Mbps Comcast service, it would read 235kbps for a long time and go up to 375kbps about midway through and only occasionally to 560kbps. The 560kbps gives 512x384 resolution. Only very early in the morning did it ever get to 3000kbps which gives 1280x720 resolution. This morning it went up to 3000kbps. I think this may be the highest resolution for this video and is perfectly fine for me. With my 1.5Mbps CenturyLink connection it will start at 560kbps and work quickly up to go up to 1050kbps (640x480 resolution) and, a short time later get up to 3000kbps (1500kbps is my ISP speed)! I think this is because it buffers for a while at 1050kbps and then plays the 1280x720 until it runs out...which for this short video it does not.
Check it out on both ISPs
Have you used the Netflix test program "Example Short 23.976"? Search for it at Netflix. Pick the 1st one as there are several and only the first one has realtime speed and resolution statistics on the screen. You can also get to a whole variety of other streaming statistics by pressing Shift+Alt+"Click on screen". That brings up a small diagnostic window with several selections.
Prior to 3 days ago, and for the last month with my previous 50Mbps Comcast service, it would read 235kbps for a long time and go up to 375kbps about midway through and only occasionally to 560kbps. The 560kbps gives 512x384 resolution. Only very early in the morning did it ever get to 3000kbps which gives 1280x720 resolution. This morning it went up to 3000kbps. I think this may be the highest resolution for this video and is perfectly fine for me.
With my 1.5Mbps CenturyLink connection it will start at 560kbps and work quickly up to go up to 1050kbps (640x480 resolution) and, a short time later get up to 3000kbps (1500kbps is my ISP speed)! I think this is because it buffers for a while at 1050kbps and then plays the 1280x720 until it runs out...which for this short video it does not.
Check it out on both ISPs
I have not tried that test program on Netflix. Thanks for the tip. I will try that when Im home, if it will ever load. I also have Centurylink. Was gonna be my previous ISP but I think I may keep it for a bit until this is all sorted out. So now it just became my backup. lol. I switched to comcast because they offer better upload speeds for when I work from home. My connection for work sucked with Centurylink and streaming sucks with Comcast. Guess I can't have the best of both worlds. The thing about it is, I shouldn't have 2 ISPs to do what I want. Its ridiculous.
ErnestNM wrote:Only very early in the morning did it ever get to 3000kbps which gives 1280x720 resolution. This morning it went up to 3000kbps. I think this may be the highest resolution for this video and is perfectly fine for me.
I believe 3000 kbps is the maximum in a browser with Silverlight. To get 5800 kbps (and 5.1 sound) on a PC you have to use the dedicated Netflix application in Windows 8.
I felt the same about two ISPs. But, since my total cost is now $20 less than before, I may stick with this arrangement so that I have a redundant internet connection. If one ISP has problems, I can use the other. However, when CenturyLink upgrades to 12Mbps in the next few months as they indicate they will, and if they continue to stream HD quality, I will likely drop the Comcast service...unless they fix their Netflix issue. And, the CenturyLink rep told me that my payment would not go up at that time...I'm not sure I believe that though.
By the way, if you don't mind, where are you located...I'm in Albuquerque, New Mexico
I'm located in Minneapolis. For Centurylink I have 20 meg/down and 856k/up. Dedicated fiber. I would have stuck with them but they dont offer higher upload speeds for what I need. But Neflix works like a charm on their network.
stinny45 wrote:
Can someone from Comcast let us know that this is being resolved or whether I should just switch isps if I want to watch Netflix? I'm about to just switch.
As we said above -
We are aware of these threads and the concerns expressed here. We are actively engaged. It is sensitive and we can't really say more than that right now.
01-22-2014 12:48 AM - edited 01-22-2014 03:14 PM
Comcast is holding Netflix hostage. Here's why. In 2012 3.2% of customers cut cable from their service yet retain internet services. In 2013 that number increases to 6.3%. And one can estimate the hemorrhaging of cable tv clients will continue, likely exceeding 10%+ in 2014 and by 2015 will likely exceed 20%+. These figures are not compounded. They are losses for each individual year.
Comcast is panicking.
At this juncture, Netflix is stating they have no legal recourse since Net Neutrality was overturned by the the circuit court, which was brought on by Verizon. The FCC Commissioner is determined to rewrite Net Neutrality with teeth (previous version was simply a prophylactic).
What can we do as consumers in the meantime?
Change ISP if at all possible.
Use our pocket books to fight back. You'll likely not need anything over 6Mbps, unless you have multiple users in your household. So downgrade your service if you can and cancel cable.
Each municipality decides who can provide ISP and cable services through a licensing service contract with the cable company. Complain about what is transpiring, pointing out the egregious behavior by Comcast and ask them to cancel their license agreements in your community because they are inhibiting your rights as a consumer. They'll open for bids and there will be other cable companies waiting in the wings to pick up the system from your community.
You may, as an individual, sue Comcast in small claims court (damages can be treble in California; a $10,000 award then becomes $30,000. No attorneys can be present (in California) and they will likely not show. There is no appellate process in small claims court. So if Comcast loses, they have no recourse. You then place a mechanical lean(s) against Comcast until full payment is received. The Mechanical lean will prohibit Comcast from improving their ISP backbone, cable, etc, nor sell, trade, etc, until all leans are satisfied. This also may interrupt dispersment of share holder's capital gains.
Starting to look like I'm going to have to "upgrade" from my 50 Mbps Comcast service to Frontiers 6 Mbps service just so I can use Netflix again. How lame.
So Jlivingood would it be safe to say from your cryptic answers that if I want to enjoy Netflix again I should switch ISPs? Honestly just saying it's a sensitive issue is not enough to keep me as a customer. I need more to go on here. I've been a Comcast subscriber for four years but am very disheartened by this recent situation and feel betrayed.
I'm sorry, but it's a "sensitive" issue because Comcast doesn't want to admit that they are holding their own customers hostage. If it were only a simple matter of overloaded ports that need to be upgraded, it wouldn't be a sensitive issue.
01-22-2014 08:57 AM - edited 01-22-2014 09:13 AM
DrMojo wrote:
At this juncture, Netflix is stating they have no legal recourse since Net Neutrality was overturned by the the circuit court, which was brought on by Verizon. The FCC Commissioner is determined to rewrite Net Neutrality with teeth (previous version was simply a prophylactic).
Comcast is still bound by the FCC's Open Internet rules by special agreement with them a few years ago -- the court ruling did not affect us.
edit -- just found the quote our PR folks released to the media on this:
Comcast Corporation Statement on action by the US Court of Appeals for the District of Columbia Circuit in Verizon vs FCC from David L. Cohen, Executive Vice President:
"Comcast has consistently supported the Commission's Open Internet Order as an appropriate balance of protection of consumer interests while not interfering with companies' network management and engineering decisions. As a result, we agreed in the NBCUniversal Transaction Order to abide by the Open Internet rules for seven years even if the rules were modified by the courts. We remain comfortable with that commitment because we have not – and will not – block our customers' ability to access lawful Internet content, applications, or services. Comcast's customers want an open and vibrant Internet, and we are absolutely committed to deliver that experience.
We are committed to work with Chairman Wheeler and the Commission to play a constructive role in finding an appropriate regulatory balance going forward that will continue to allow the Internet to flourish. Given the DC Circuit Court of Appeals holding that the FCC has jurisdiction in the broadband arena to preserve and facilitate the innovation that has driven the Internet, we are optimistic that the Commission can accomplish this result while avoiding inappropriate common carrier regulation."
If your playing within the FCC's rules then why is this such a sensitive matter? We are just asking for a timeline for this to be fixed. You can see your customers are leaving for other vendors as they can't get what they are paying for or an answer on when and if this might be fixed.
01-22-2014 01:09 PM - edited 01-22-2014 01:10 PM
Can you confim whether or not this will be in fixed in the near future? I have been a Comcast subscriber for over 20 years and between this problem and the X1 "beta" technology, I am at my wits end! I have been patiently waiting to see how X1 develops and with this lastest Netflix issue, I am almost out of patience here.
If you confirm that there is in deed a known problem and it WILL be fixed sooner than later, I can accept that. So, JL (or any Comcast employee), how about alittle more transparency on your part.
01-22-2014 01:20 PM - edited 01-22-2014 03:11 PM
JL - You are, without question, misrepresenting the facts, producing disinformation. You are unquestionably filling the role of a public relations mouthpiece on behalf of Comcast.
The press release is utter rubbish. If they were following what they claim to be saying, this would unquestionably not be happening. Therefor, the press release is disinformation. It doesn't take a rocket scientist to figure this out.
And if Comcast claims it is somehow bound by FCC oversight, in this case, since the overturn of Net Neutrality, it is clearly falling on deaf ears and you are, without question, overstepping your obligations to your clients. Corporate attorneys are paid assassins - They will find any means to circumvent businesses and consumer rights.
I absolutely disagree with your spin on the matter. I am fully aware Comcast is not only throttling Netflix, but ramping speeds up down simultaneously within the throttling footprint, making it nearly impossible for some streaming platforms to settle upon a speed, thus causing streaming platforms to produce unwatchable Netflix content; freezing, crashing, which in the case of a Samsung Smart Hub, requiring the consumer to pull the power supply. This in turn stresses capacitors in the set which may lead to intentional (malicious) damages by Comcast.
Furthermore, you are ignoring industry stats. Comcast is seriously threatened by cable cutting and the impact Netflix has had upon Comcasts business model(s). But on the other hand, most clients will think the issue is with Netflix when it is unquestionably under Comcasts control. This is deemed as intentional industrial sabotage.
Comcast is out to produce maximum damage upon Netflix, instead of reinventing itself. This is the future and if one doesn't adapt, one will simply left behind.
Netflix is the only service being treated this way. This has been validated through extensive research and testing. No other streams, at this time, are inhibited. Research statistics do not lie.
I have personally contacted House and Senate members of mass-com, technology committees with regard to the unfettered abuse by Comcast in their constituency districts. Mr. Rockefeller (D-WV) is fighting the overturn and is exploring a means to get ISPs in line. DC is closed, at present, due to a severe snow storm. So if you want to voice your opinion, do so at the local level. Also be aware, if you use the Congressional mail systems, your complaint will likely take well over 30 days before it even reaches the representatives offices. Use FAX numbers, again, in the representatives constituents districts to voice your opinion. You'll expedite awareness in a more timely manor and increase efficiency in the process. The more complaints, the quicker the government will respond.
Comcast through inhibiting throughput violates consumer rights and protections. But worse than that, they are damaging their own name brand. Once the public becomes more enlightened on the matter, more subscribers will become even more infuriated and will be more prone to be proactive. Understand, this literally impacts millions of Americans. It is hard to conceive this will be allowed to continue, but it will take time, and even longer, if you do not voice your opinion.
As as far as some sort of settlement between both Comcast and Netflix, Comcast is attempting to extort hundreds of millions of dollars, annually, through this so called process. And it will never end.
If this precedence is established, every IP business will be impacted, forever, and will be at the mercy of all ISPs extortion schemes.
01-22-2014 01:42 PM - edited 01-22-2014 01:42 PM
Not going to do us any good to complain to the press or anyone else. Comcast has already stated that they "are actively engaged" in getting the issue resolved. Presumably this means they are in talks with other parties to get the issue fixed. For now, I think we'll just have to be patient.
Nurdburg. If I understand what you are saying, lets all put our heads in the sand and ignore what is transpiring. I'm afraid passivity will only make matters worse, in this case.
banditsc wrote:
Check your PMs
stinny45 wrote:
Check your PMs
DrMojo wrote:
Nurdburg. If I understand what you are saying, lets all put our heads in the sand and ignore what is transpiring. I'm afraid passivity will only make matters worse, in this case.
All I'm saying is that I think Comcast has heard us and we need to give them a little time to get the situation settled.
I've had this same issue for over 2 months now. I'm really contemplating dropping Comcast or at least dropping my internet speeds since there isn't any reason to pay for fast speeds if I can't even get Netflix to stream in HD.
Also, what is with the secrets JL? Instead of sending certain people PM's, why don't you just post an update on here so everyone can see it?
jlivinggood and Comcast's other employees not saying anything usefull on this issue is just one of the many reasons why Comcast constanly ranks near the bottom if not at the very bottom in customer service.
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Some people 'too obese to help': Your comments
Dr David Haslam, from the group Experts in Severe and Complex Obesity (ESCO), warns people who are biggest should just be offered "palliative care" rather than surgery for their obesity.
Weight-loss surgery has the capacity to permanently induce major weight loss. However, the availability of surgery is limited and Dr David Haslam says it should be offered to those who need it most.
BBC News website readers have sent their comments.
Your comments
I agree entirely. I am an anaesthetist who does bariatric cases. We do not have an age limit, as it would be perceived as ageist, but the older (60+) fatter ones with some of the worst comorbidity, from what I can determine from the evidence, have a much higher perioperative mortality (10%ish), and clearly, being older, generally have a shorter life expectancy. I think the aim should be prevention, and maybe cure for those with diabetes, OSA, and hypertension. Cosmesis should not be a consideration at all.
As someone who used to have a BMI of 37 (now 22 due to diet and exercise) I sympathise with both Doris and Sean. Both, in my opinion, should receive the operation. I was very lucky in that sheer willpower saw me through, and although at my biggest I was "pre-diabetic", I didn't have any other underlying health problem that prevented me from losing weight. I feel my age, 25, was also a big help. Losing the weight has meant I have prevented myself from getting type-2 diabetes, a disease which affects many members of my family. Although Doris has been demonised by "smoking 40 a day", given her current quality of life I should imagine that this is one of very few pleasures in Doris' life and that she should also receive support for combating this. It is a vicious cycle but the key point here is to get Doris active again and it has got to the stage where the operation is the only means of doing this.
After careful consideration of the above facts, with Sean weight loss is achievable. He has dependents, can work, can pay taxes and with good care his treatment would be cost effective. In an ideal world both Sean and Doris should benefit from surgery but if a choice has to be made, Sean should have the surgery before Doris.
I am 57, 4ft 10 with a BMI of 43. I have my share of health problems and a family who would help all they could in getting me fit again. I would love to be able to just do the walking I did 10 years ago, or have the energy with my grandchildren that I had with my own children. Your example reminded me of attitude tests. There is one where people are trapped down a mine and there is only time to save a few, who should be first? The mother with 2 small children who represent the future was last. The big fat business man was first, even with his bad health, because he was about to sign a big new important contract. If it were a choice between Sean and myself, it would have to be Sean, and until we could both have the operation it would always have to be people like Sean.
I had a BMI of 36+ but rather than expect other people or the NHS to assist me, I undertook a personal project to reduce my weight. I used sensible eating rather than dieting, for example cutting out snacks and late evening eating, I also did concerted exercising starting small and then gradually building up to 45 minutes per day. I also undertook walking at least 10,000 steps each day by not taking the car to work and walking wherever possible. I now have a healthy BMI of 22.76 and lost a third of my body weight in the process. This took 9 months of determination on my part and support from family and friends, but I feel much better and have a better and more productive life as a result of losing all that weight. People who have to take medication for other illnesses that increase their weight should not be denied surgery or assistance to lose weight. However, for the vast majority of people, they could lose a lot of their excess weight themselves.
The sooner obesity is recognised as a mental illness the better - it is comparable to anorexia, and should be treated as such.


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CROSS, VINETTE, Shah, P., Glynn, M. and Chidrawar, S. (2009) ReGAE 5: can we improve the surgical journey of African-Caribbean patients undergoing glaucoma filtration surgery? Some preliminary findings Clinical Ophthalmology (Auckland, N.Z.), 3. pp. 1-12. ISSN 1177-5467
Cross, V., Shah, P., Glynn, M. and Chidrawar, S. (2008) Research into glaucoma and ethnicity (ReGAE)4: trabeculectomy for advanced glaucoma: the surgical journey of African-Caribbean patients Eye, 22 (12). pp. 1456-1458. ISSN 0950-222X


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JustCode JustRocks
I have been a ReSharper fanboy for a long, long time. I have recommended it in user group and conference talks and on my blog. It was one of my favorite tools for a long time, and it remains a great product. However, I'm happy to say with all honesty that I now prefer JustCode. This is fortunate, as I now work for the company that makes JustCode, but I've held off on endorsing it (or completely replacing ReSharper in my actual work) until I felt it really met my needs. That day has come. Let me share with you why I'm now a convert. Must-Have Refactorings There are a few refactorings that I use all the time because of the way I write testable, maintainable … more


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Written by: Dan Empfield
USA Triathlon, America's national governing body for triathlon, has granted World Triathlon Corporation (Ironman and 70.3 triathlon events) the ability to disallow swimskins in non wetsuit races, and wetsuits thicker than 5mm in wetsuit-legal events, for all WTC events taking place on or after September 1, 2010.
This date is the anniversary each year for Ironman qualifying, that is, races that occur after September 1 qualify entrants for the subsequent year's Kona and Clearwater World Championships, hence this effective date for the new rules.
This rule dispensation disallowing certain wetsuits and swimskins follows the publication, by WTC, in early February, of an Oceanside 70.3 athlete guide containing these new rules. Following a day of public discussion of these athlete guide rules on Slowtwitch.com, WTC quickly replaced the athlete guides with those making no reference to the rule dispensations they sought from USAT.
As of this week these rule dispensations have been granted by USAT for Ironman-owned and licensed events, though only after a sunset period.
Water temperature standards also change on this September 1 date. All WTC races after September 1 will be wetsuit legal if the water is 76.1°F or colder. This is the Fahrenheit equivalent of WTC's intent to disallow wetsuits above 24.5°C. This temperature standard is in between the ITU's 24°C and USAT's 78°F.
This means that only a small fraction of the thousands of USAT-sanctioned multisport events held in the U.S. each year will be subject to these new wetsuit thickness, swimskin, and temperature cut-off rules.
"It will be near the end of the year before we make any kind of judgment one way or the other," said Gilbert, speaking on whether USAT will enact new rules for all its sanctioned events. "The impact would not take affect until 2011 or 2012. If we deem our temp [for wetsuit legality] should be other than 78, we might activate this for the next racing season [after January 1, 2010]."
WTC also sought the ability for its entrants to use CE or AU helmet certifications in races taking place inside the United States (this because many foreigners travel with their foreign-purchased helmets to Ironman Florida, the Hawaiian Ironman, the Clearwater 70.3 Worlds, and other events). USAT declined this request, as it has done several years in a row, standing on the principle, according to Gilbert, that because the CE standard is, "not quite as strong, we don't want to go backward; we don't want to loosen the standards."
The dispensation requested on wetsuit thickness was, according to Gilbert, limited to wetsuits "5mm thick or less." Limiting our scope to wetsuit—and not grammatical—standards, what does a wetsuit "5mm thick or less" encompass?
Some rubber manufacturers adhere fabric jersey to rubber sliced to a thickness of 5mm, making the total wetsuit panel thickness 5.5mm or 6mm. Would such a wetsuit be legal in WTC races? "If I measured it, and it is, then I would say no," replied Jim Riccitello, head of WTC's officiating corps.
"I would say that, like most of our rules, we look for guidance on technical issues from international and national federations," continued Riccitello. "It's not our job to define a wetsuit. We hope that that happens, but, up 'til now, we're simply adopting the international standard. My feeling, without knowing how wetsuits are constructed, manufacturers are adhering to 5mm or less. We're just trying to be proactive, before we have somebody waddling down to the swim start in a neoprene canoe."
Still, Riccitello acknowledges that, with USAT not likely to adopt any wetsuit product verbiage at all until late in 2010 at the earliest—for a rule not likely to be adopted until 2012—WTC may be forced to wade into the waters of wetsuit rule crafting. Should USAT not preempt WTC prior to September 1 of this year, "We'll attempt," said Riccitello, "to define what a wetsuit is."