text:
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Introduces the skills needed to create photorealistic 3D creatures for film, video, and game production.
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text: ChesapeakeMan Carbo Dinner and Champions Brunch Tickets are available for all who would like to attend. They are free to ChesapeakeMan (full IM) participants but you must RSVP by Sept. 26th. All others are welcome to attend at the price of $30 for dinner and $25 for Brunch. Please RSVP by Sept 26th to Jane at the CTA office and be sure to obtain your ticket at packet pick-up! Hope to see you there!

subset: commoncrawl


text:
By Leila Rheaume
When I was little, my sister used me as an excuse.
She would offer to take me to the playground at the end of our block and then meet her boyfriend there. They would wander off for the best measure of privacy allowed and I would be left on the swing set, pumping my legs half-heartedly at the evening air. If you gave it any force at all, the rusty old chains would click back and forth and pinch the skin of your palms.
She was a sheep in wolf's clothing the night she died. Bright red crop top, matching mini skirt, chunky heeled boots that hugged her legs up to the knee. I followed her and Brendon around that evening, fascinated by the way he laid his hands and mouth on her, like he wanted to become her. Like he couldn't stand not being a part of her. I tailed them from the slide, to the see-saw, to the roundabout, until they finally gave up and ran laughing into the road where they knew I wouldn't follow.
It was drizzling and the street lamp reflected the specks of water in the air, giving the impression that it was snowing in the oval of light surrounding the two of them. My sister's damp strawberry blond hair glowed like the flickering embers that rise up when you poke a dying fire. A car swung onto the road, its high beams perfecting the moment, lighting them up from one last angle like the final act of a play.
But the car didn't slow and they didn't move. I wanted to shout, to warn them, but I thought surely, surely they saw it.
Just before the impact, he shoved her, trying to get her out of the car's path. It wasn't fast enough or far enough. She sprawled into the street and was sucked under the front tire, then the back, the force it rolling her body along for a few feet in the car's wake. She never screamed. I think I would have been more horrified if she screamed.
The car hit Brendon at the legs and his body slammed into the windshield before spinning, sailing up over the top in a grisly display of acrobatics.
Later, they called me a hero because he lived. I was the brave little girl with the presence of mind to dial 911. The reporters and the fifteen minutes of fame they brought with them were the worst. I wanted to explain to them how I didn't call out a warning, so they would be disgusted with me and stop asking me stupid questions like, 'Do you miss your big sister?' I wanted to tell them how I was the one who chased her into the road in the first place. But I wasn't even brave enough to confess.
They told Brendon he was fortunate to be alive, that he wouldn't have made it if I hadn't gotten help in time. I imagine him hating me for it. If only I hadn't hesitated, he wouldn't have been 'lucky' to be stuck in a wheelchair with one useless leg and another amputated at the knee.
I wasn't there to save him six months later when he shot himself in the temple with his father's duty weapon. Sometimes before bed I wonder, was it the handicap or was it her? It shouldn't matter, but I like to believe it was because of her. My sister. The angel in go-go boots.
It's morbid but I want to die like her. Young, beautiful, spotlit, burning with a passion so devastating that even an oncoming car is beneath my notice.
I turn my cheek onto the hood of my beat up '81 'vette and study the boy beside me. He's pretending to enjoy the soft blues playing from the speakers. My thoughts are as cold as the metal of the car and not even Jeff Buckley's ethereal voice can heat them. There is nothing between me and this boy but his desire to get to second base or beyond. He wouldn't wither and die from the lack of me. He isn't the one. He isn't Brendon and I'm still not her. Anyway, the light isn't right. I slip the razor edged paring knife back into the sleeve of my coat, a step not to be taken.
I deserve better. I deserve a boy who will stay my knife, not because he's lukewarm, but because I can't stand leaving him. Because I can't take the chance that there's no heaven where we'll meet again.
The catch-22 is obvious. If a boy isn't good enough, perfect for the moment, then I can't do it without tainting her memory. If he is, I won't want to. Excuses, excuses. I make room for them in my life. I nurture and pamper them. It's healthy to have a reason to live, right? And anyway, I know better than anyone that excuses eventually get you killed.


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Mortgages and real estate changed dramatically in '06. Have you learned the lessons well enough to apply them in '07?
Whether you already have a mortgage or you plan to buy a house in the next year, here are seven mortgage tips for 2007.
1. Review your mortgage -- does it still fit your circumstances? Homeowners with mortgages should assess their home loans annually, bankers say. Naturally, you would expect lenders to say that. It's a good idea anyway. Interest rates change, children are born and grow up, sometimes you need to fix up the house and sometimes you need to move on. Life events can trigger changes in the way you pay for your house.
"Every year," says Dan Hanson, who oversees the retail branches for Countrywide Home Loans," say, 'What's going to happen this year?' Do I have a child who, in a year, is going to college? Are we going to have a child, maybe add a bedroom or have to move?'" The answer might make you go mortgage shopping.
For example, let's say you plan to move in a couple of years because your family is going to grow. Consider getting an adjustable-rate mortgage with a low initial rate that lasts three years (a "3/1 hybrid ARM"). That initial rate probably is lower than the rate you're paying now and the same with the monthly payments.
Before refinancing to save money, make sure you won't get zapped with a prepayment penalty, either when you refinance or sell the house. Calculate the cumulative monthly savings to see if they decisively outweigh the closing costs. If not, keep the current loan.
Hanson believes that you should ask yourself periodically: "Is my interest rate higher than the market today? Would it make sense to refinance, to take cash out? Would it be a good idea to get a reverse mortgage?"
And one other question: "How much is my house worth?" Ask a real estate agent who is active in your neighborhood. It's a good way to introduce yourself to the person who might someday help you sell the house. For a quicker, but less-accurate estimate, consult Zillow.com.
2. Watch out for reset. Have you ever seen a cartoon where Bugs Bunny stands at the base of a cliff and he yells at someone standing on the cliff's edge, "Watch that foist step. It's a doozy!" Same thing with a lot of adjustable-rate mortgages: The first step is a doozy -- but up instead of down.
The rate adjustment is called the "reset," and on hybrids such as 3/1 and 5/1 ARMs, the rate can jump as much as 5 percentage points. More realistically, a lot of borrowers face jumps of 3 percent to 3.5 percent in 2007. For interest-only borrowers, that might mean a doubling of the monthly payment.
This is why Hanson suggests reviewing your mortgage annually. Don't get caught by surprise by a rate reset. Refinance the loan if it makes sense to do that.
3. Don't pay the minimum on an option ARM. An option ARM is an adjustable-rate mortgage that lets you decide how much you pay each month. You can make a payment that's big enough to pay off the mortgage in 15 years or in 30 years, or you can pay only the interest, or you can make a minimum payment that doesn't necessarily even cover that month's interest.


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Dean Kilpatrick, Reporter
Wednesday, July 11, 2012
Julian Brazier, Tracey Crouch, Gareth Johnson and Adam Holloway vote against government
Four Conservative Kent MPs rebelled against the proposed House of Lords reforms in parliament yesterday.
Canterbury MP Julian Brazier, Chatham and Aylesford MP Tracey Crouch, Dartford MP Gareth Johnson and Gravesham MP Adam Holloway all voted against the coalitions plans to make the Lords an elected chamber.
However, despite the biggest rebellion the coalition has seen since its formation, the principle of the proposed reforms passed through parliament.
Dartford MP Gareth Johnson told the House of Commons that they should "abolish it at our peril".
He added: "I feel bitterly disappointed that I shall be voting against my party - sick to the pit of my stomach, in fact.
"But I shall leave this chamber with my head held high (and) able to look myself in the mirror.
"The House of Lords works; it has stood the test of time."
Beckenham MP Bob Stewart also voted against the proposals.
Other Kent MPs backed the motion though, including Thanet MP Laura Sandys who insisted Lords reformed was urgently needed.
She said: "This is not a Liberal Democrat Bill - restoring power to the people is at the heart of Conservatism. In this Parliament we have already introduced legislation for elected police commissioners and have promoted city mayors.
"It is absurd to criticise the EU's lack of democratic mandate but to turn a blind eye to the 825 members who sit on the red benches as a result of some form of patronage.
"Reform is an essential component of strengthening Parliament in the face of a stronger executive. With greater resources and more activism in the House of Lords, both chambers will have an increased capacity to hold Government to account."
Despite the principle motion being passed, the government decided to drop the vote which would have set out a timetable for the Lords Reform Bill.
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text:
A few days ago, when reviewing our spam traps, we came across some normal-looking Canadian Pharmacy spam messages. The html is shown below:
The unusual feature of the spam was that some of the "Click here" links were all messed up and, instead of an http link, had references to SpamIt.com in the href attribute. Below are html snippets from three separate messages:
SpamIt.com is a secretive, invitation-only, group of email spam affiliates closely linked to GlavMed, which in turn is responsible for one of the largest and oldest affiliate programs called "Canadian Pharmacy". Recently, Canadian Pharmacy has been the dominant spammed program – by far. Our analysis from a few months ago found that links to Canadian Pharmacy sites comprised 60-70% of all spam, and is simultaneously spammed by most of the major spamming botnets. For anyone interested in a wider discussion of the Russian affiliate networks, refer to "The Partnerka – What is it, and why should you care? " – it is an excellent read.
The Spamit.com domain is up, but naturally, requires authentication to access the site:
The spam samples themselves originated from the Xarvester botnet, which rose to prominence right after the McColo take down affected the major spam botnet at the time, Srizbi. However, nowadays Xarvester only represents under 1% of the spam we are seeing. Still, the above reminds us that SpamIt.com is very much alive and continues to use spamming botnets to push its wares.


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I'm not suggesting that there is some kind of "cosmic encyclopedia".
I'm suggesting that there is a fourth dimension (at least) of thought. Perhaps more. Music? Pathos? Time? I don't think the world can sufficiently be explained by just the three dimensions of space, and string theory suggests there may possibly be ten such dimensions...
I'm not suggesting that there is some kind of "cosmic encyclopedia".
Of course you are. You're just calling it "a fourth dimension of thought" rather than a "cosmic encyclopedia". Your basic concept is that thought or knowledge exists independently and the brain only accesses it. (How? Telepathy? Radio waves? Morse Code?)
I'm suggesting that there is a fourth dimension (at least) of thought.
Without a single shred of empirical evidence, you might as well be suggesting we play a game of choo-choo train.
Well, you certainly can't prove any of what you speak of to be true, you can only deduce the probabilities of it's likelihood, and even then, I fail to see how you could ever prove your deductions were correct. But if you enjoy pissing into the wind, far be it from me to stop you.
Of course a tree makes a sound when it falls in the forest - the same sonic mechanics that act to create the sound a human hears, don't suddenly cease to operate in his/her absence. As far as this planet is concerned, Man is entirely superfluous.
RE: "Heather Spoonheim suggested that some concepts are too large for a single brain to comprehend" - yes, well that was Heather's fault for offering you something you could sink a hook into, and I suspect she's regretting volunteering same.
I am not actually speaking of anything and have never even stated a position since I have none. Every post I have made has been framed as an honest question. You guys seem to be on some kind of blind theist-hunt. I came here because it said "Fellow Atheists, what is your take on Dualism?" I didn't expect to walk into some kind of monist Inquisition.
So thinking = pissing into the wind? If everyone thought that we'd still be living in caves.
We know sonic mechanics exist. We know abstract ideas exist. Does that make consciousness superfluous to both? Sonic mechanics exist in the physical world. Where do abstract ideas exist?
I said: "I fail to see how you could ever prove your deductions were correct. But if you enjoy pissing into the wind, far be it from me to stop you."
Could you enlighten me as to how your ability to prove your deductions would in any way facilitate or prevent our living in caves? I'd just like to understand how your mind is capable of making such a connection.
You've spent a lot of time throwing around E=MC2 - what would you call that, an abstract idea?
I'm not talking about my deductions per se, I'm talking about thinking in general. It has merit, thinking that is, and is not just 'pissing into the wind'.
Yes I would call E=mc2 an abstract idea. Wouldn't you?
E+MC2, combined, as they one day will be, with yet-to-be discovered principles of quantum mechanics, operated the Universe long before Man permanently leaped down from the trees, and will continue to do so long after the trees themselves are gone. Our "abstract idea," regarding E+MC2, was nothing more than our perception of its effects, much as we derive our concept of what causes wind by watching its effect on the objects around us.
Have you another explanation?
Yes, they operate the universe, but my question is where do they exist? Everything else we perceive exists somewhere. I can see the table. It is there. Where is E=mc2? If E=mc2, what does E+mc2=?
Where does the number 1 or 2 exist? As Sagacious Hawk suggested, and against my better judgment, am reposting this in the philosophy forum under the title "Dualism and Monism - An Atheist Viewpoint". I've tried to order some of the questions I think are appropriate, and hopefully bring some structure to this tangled thread. I just want to state again, AGAIN, that I am not offering answers, since I don't even have a position to argue from. I'm just posing questions I think are interesting. Thanks
Anon, you're confusing the forces with the concepts defining them - the forces exist everywhere, the concepts exist in the minds of Man and possibly other sentient beings throughout the universe.
Yes that is true, but still doesn't resolve the problem of where the pure concepts exist, if no-one is there to see them? The effects of these concepts exist, we can perceive the effects, but everything that we can perceive having an effect, has a place. Where do the pure concepts exist?
Do you think we could possibly move this discussion here? Will add the response you posted since it answers some of the questions I posed. Thanks.
The tree falls, and we both agreed that the sonic particles exist. Where do the pure concepts exist?
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text:
A shoal of herrings greeted people into the Minster throughout the festival.
Lucy Clapham
Monday, September 24, 2012
GREAT Yarmouth's debut arts festival has been hailed a fledgling success after helping to paint an alternative picture of the town.
Organisers of the three week event, which came to a close on Saturday, were keen to showcase the resort's rich artistic talent and historic side, as well as raising the profile of the landmark Minster - one of the town's most important buildings.
And the event was lauded for completing its artistic aims after visitors and locals said the packed programme - of music, art and heritage workshops - had opened their eyes to the town's history and homegrown artists and shown them a different side to the seaside resort.
It also brought scores of visitors into the Minster after the signature exhibition, which was held at the church throughout the festival, attracted 3,000 people from across Norfolk, Suffolk and further afield.
Hugh Sturzaker, festival chairman, said: "I think it has shown another side to Yarmouth.
"One of the aims was to raise the profile of the Minster not just as a place of worship and that's certainly been successful. All the visiting artists have said what a magnificent building it is and many want to come back.
"I think it's also helped bring the congregations of churches in Yarmouth together."
Mr Sturzaker admitted there had been some elements that had not proved to be as strong as hoped - such as contributions from the town's international population and getting youngsters into performances - but these were areas to be worked on for future festivals, and several people have already come forward to help bolster its position in the town's annual calendar.
He added: "Getting it started is the difficult thing but hopefully it has got a little bit of a reputation, which might help it do better in future.
"It's been good but I'd like to build on it. If you look at the Out There festival; five years ago it was tiny and now it's an amazing, vast organisation.
"We're now going to sit down and decide how we could do better, what were the good points and what should be the future."
Mr Sturzaker wished to thank all the individuals, firms and groups that had supported and sponsored the festival, including Gardline and the Mercury.
2 comments
I was able to enjoy one or two events and all credit to Mr Sturzaker and everyone trying to inject a little life and culture into GY. However the town is being let down by the council failing to work with the owners of retail units and the Market Gates complex and with store operators to retain retail outlets in the town. The Coop, Peacocks and Dorothy Perkins stand empty. Top Shop has gone, Mackays is closing down and apparently River Island and Burtons are closing soon.This is as well as the branch of Homebase at Southtown and branches of chains which have gone out of business such as Clinton Cards,Select and Game. This is the second largest town in Norfolk and it is a retail desert.
Monday, September 24, 2012
'Its also helped bring the congregations of churches in Yarmouth together' - Sturzaker.I think that the closures of other churches in the borough have done that mate.
Monday, September 24, 2012
The views expressed in the above comments do not necessarily reflect the views of this site


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text:
Over the course of the workshop, several panel presentations concluded with general discussions of the major issues affecting the development and use of biomarkers. These discussions focused on three main issues: creating incentives for organizations to collaborate, moving forward even when a thorough understanding of biological mechanisms is lacking, and dealing with different levels of risk in biomarker development.
Janet Woodcock noted that approximately half a million reports of drug-induced injuries are submitted to the Adverse Event Reporting System annually. These injuries represent both a major public health problem and substantial health care costs. At the same time, observed Daniel Bloomfield, the expectations for safety and the amount of research needed to get a drug approved have increased, even though the typical commercial life of a drug has not changed. Given the reduced returns from drug development, fewer companies are pursuing difficult projects with the potential to reduce the toll of drug-induced injuries.
Woodcock emphasized that investing millions of dollars in basic research and hoping that the resulting knowledge will automatically become available for use in human populations may be insufficient. Instead, special initiatives often are necessary to translate new knowledge into results that can have an impact on health care. Woodcock cited two such projects that have been supported by the Foundation for the National Institutes of Health (FNIH). One is the Alzheimer's Disease Neuroimaging Initiative,
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OCR for page 58
Future Considerations
Over the course of the workshop, several panel presentations concluded
with general discussions of the major issues affecting the development and
use of biomarkers. These discussions focused on three main issues: creating
incentives for organizations to collaborate, moving forward even when a
thorough understanding of biological mechanisms is lacking, and dealing
with different levels of risk in biomarker development.
CREATING INCENTIvES FOR COLLAbORATION
Janet Woodcock noted that approximately half a million reports of
drug-induced injuries are submitted to the Adverse Event Reporting System
annually. These injuries represent both a major public health problem and
substantial health care costs. At the same time, observed Daniel Bloomfield,
the expectations for safety and the amount of research needed to get a drug
approved have increased, even though the typical commercial life of a drug
has not changed. Given the reduced returns from drug development, fewer
companies are pursuing difficult projects with the potential to reduce the
toll of drug-induced injuries.
Woodcock emphasized that investing millions of dollars in basic research
and hoping that the resulting knowledge will automatically become avail-
able for use in human populations may be insufficient. Instead, special
initiatives often are necessary to translate new knowledge into results that
can have an impact on health care. Woodcock cited two such projects
that have been supported by the Foundation for the National Institutes of
Health (FNIH). One is the Alzheimer's Disease Neuroimaging Initiative,
OCR for page 58
which also has been supported by NIH and industry and in which the FDA
participates. Another is the Osteoarthritis Initiative, a prospective investi-
gation of a large number of potential biomarkers. In addition, Woodcock
noted that the FNIH helped establish the Biomarker Consortium, a major
public–private biomedical research partnership with participation from a
broad and diverse group of stakeholders, including government, industry,
academia, and patient advocacy and other nonprofit private-sector organi-
zations. The goal of the Biomarker Consortium is to collaborate in rapidly
identifying, developing, and qualifying potential high-impact biomarkers.
Many workshop participants stressed that such collaboration among
industry, the FDA, and academic researchers could yield much more rapid
progress in the development of biomarkers. The question then becomes
whether incentives could be established to promote such collaboration.
One important set of incentives, according to Frank Sistare, would be
clear agreement on the data that could be generated in regulated phases
of drug development that would not need to be submitted to regulatory
authorities. When drug development is in its earliest stages, companies need
freedom to operate without worrying about having to submit all such data
to regulators, who may then decide that the development process should be
slowed so that certain concerns can be probed more thoroughly. The FDA
has offered guidance on these decisions, and there is an ongoing dialogue
with the agency to clarify the issues involved. But the current lack of clarity
continues to inhibit industry from generating data that could be extremely
useful for fear that the data could be used to slow drug development.
Government and industry need to be creative in implementing incen-
tives and removing disincentives, Sistare continued. For example, could
a company be offered a reduction in user fees for the submission of data
related to the discovery or development of safety biomarkers deemed criti-
cally important by regulatory authorities, or could it gain a period of added
exclusivity for a product? Although both of these steps would require legis-
lation, they represent the kind of out-of-the-box thinking that is needed.
James Stevens of Eli Lilly suggested that incentives might include stag-
gered goals for what can be done in 1 year, 3 years, and 5 years. Some
research projects take relatively long to complete, and potential partners
in collaboration may be unwilling to participate unless they know when
particular goals should be achieved.
Other workshop participants questioned the practicality of establishing
new financial incentives to foster partnerships. Given the many financial
demands on the federal government, said Alastair Wood, incentives that
require additional funding probably will not succeed. Unless collaborations
have realistic objectives and expectations, the potential to make progress
through cooperation may be forfeited. Wood also questioned why incen-
tives are necessary if a partnership results in drugs being developed more
OCR for page 58
quickly and with less investment of resources. If a given partnership makes
sense, why are incentives needed to foster it?
According to Robert Califf of the Duke University Medical Center,
multi-institutional partnerships and collaborations with industry will be
necessary for substantial progress to occur. This requires both "big sci-
ence," characterized by extensive cutting-edge technologies, and "big popu-
lations," where associations can be detected and refined. An undertaking
of this magnitude, Califf observed, is too big for individual companies,
even large multinationals, no matter how global they are. The same is true
for individual academic centers, even those with broad, interdisciplinary
skills and knowledge. Califf described his own experience with the recently
launched David Murdock Research Institute as an example of the type of
partnerships that will be required in the future. Created by a major philan-
thropic gift, the Institute is a collaboration among Duke University, the Uni-
versity of North Carolina (UNC) system, and Dole Foods. The Institute also
has links to universities and industries throughout the United States, and
partnerships with organizations in India and Singapore. Substantial funding
has enabled the Institute to combine large-scale biobanking and state-of-
the-art technology with support for manufacturing and commercialization.
Califf characterizes the Institute's approach as a "factory approach to bio-
markers development."
Califf further observed that existing public–private partnerships have
been inhibited by uncertainty about how to manage conflicts of interest
when public entities and for-profit corporations work together. A lack of
clarity about the terms of engagement can stifle creative solutions.
Interests and incentives will vary even from one federal agency to
another. For example, NIH has taken on important responsibilities, such as
the Drug Induced Liver Injury Network (DILIN) and the Biomarker Con-
sortium, that differ from the responsibilities of the FDA. Yet interagency
collaborations have already begun to emerge, as exemplified by FDA and
NIH interactions with respect to the DILIN initiative and the Biomarker
Consortium. Successful partnerships hinge on finding common ground
among agencies and between the federal government and industry. If impor-
tant tasks are being overlooked within the federal government, it may be
necessary to develop a new infrastructure within a federal agency to carry
out those tasks. For example, a new, independent, cross-agency institute
may be needed to foster biomarker development, suggested Richard Paules
of the National Institute of Environmental Health Sciences.
John Bloom pointed out that partnerships could help establish stan-
dards for submission databases, review databases, and electronic medi-
cal records. Greater standardization throughout the biomarkers field also
would encourage more sophisticated approaches to informatics. Bloom
expressed the opinion that biomarker development faces no insurmount-
OCR for page 58
able barriers that cannot be overcome through a coordinated effort. But
opportunities need to be seen as worthy of the attention and resources of
Wood also noted that many stages of biomarker development lend
themselves to a noncompetitive structure. The more information that is
shared among companies, the more productive research will be. Many
companies see secrecy as essential to gaining an advantage, but secrecy
also works in reverse. For example, other companies may have informa-
tion about problems with another drug in the same class as the drug under
development. A drug that proves to have problems early in the develop-
ment process often is not extensively discussed outside the company that is
developing it. Sharing such information could reduce the costs of research
without compromising competitive positions.
Concluding the discussion, William Mattes of the Critical Path Institute
suggested that any incentives put in place need to be carefully considered
and structured so they do not create the appearance of favoring individual
stakeholders. Incentives will be successful if they account for the vary-
ing interests of different groups. For example, academic researchers are
rewarded for publishing their work and are unlikely to share information
extensively before publication. Similarly, a company has incentives to work
on its own compounds rather than in partnership with other companies on
projects that are not directly product related.
MOvING FORWARD WITHOuT uNDERSTANDING MECHANISMS
As Califf pointed out, it is possible to make predictions with bio-
markers that are probabilistically quite accurate without knowing much
if anything about the mechanisms behind those biomarkers or the biologi-
cal processes they reflect. This is already the case with cancer treatment,
with physicians and patients being able to purchase multiple prognostic
tests, each based on somewhat different arrays of biomarkers. While such
options are available, however, it is always preferable to understand the
mechanism involved because of the possibility of developing new targets
for treatment or redesigning molecules to avoid toxicity by not engaging
the mechanism.
Ravi Iyengar of Mount Sinai School of Medicine, whose workshop
presentation addressed the role of systems biology in biomarker develop-
ment (see Box 6-1), put the issue in a different context. Often a general
mechanism is apparent for 90 percent of the cases of a disease or adverse
drug reaction, and most of the other cases can be accounted for by using
more tests and statistical associations. But 1 percent of cases may remain
mysterious unless a biological mechanism is understood extremely well. If
a signature for these outliers exists, Stevens asked, will clinicians be com-
OCR for page 58
Systems Biology and Biomarker Development
In his presentation, Ravi Iyengar described the challenges facing systems
iology, as well as the potential of this new perspective on biological processes
to aid in the development of biomarkers. There are several definitions of systems
biology. In the context of biomarker discovery, Iyengar described systems biology
as the use of computational approaches to drive understanding. Network and
statistical models that are implemented computationally are used to probe how
the parts of a biological system function together. An understanding can be gained
of how and why a complex biological function occurs as it does, although detailed
mechanistic understanding of a molecular interaction may require different kinds
of studies.
Biological systems exist at different levels—from the organ level, to tissues
and cells, to intracellular networks, to the molecular level. Many of the actual
physiological measures in medicine are made at the level of clinical analysis and
indicators. Systems biology models can often relate events at a lower level to clini-
cal outcomes. A great challenge for systems biology, said Iyengar, is to integrate
understanding of these different levels vertically.
As an example of a correlation without detailed understanding, Iyengar cited
an FDA-approved breast cancer diagnostic that is based on 70 genes, while an
lternative diagnostic is based on 76 genes. Yet the two sets have only three
genes in common, which raises the question of how the sets are related. Research
in Iyengar's laboratory has shown that both sets of genes are linked to overlapping
sets of upstream transcription factors and signaling. In turn, transcription factor
activity profiling and network analyses can help identify relationships between
mutated disease genes and prognostic gene expression signatures. This is one
way to connect events at different levels, enabling oncologists to use molecular
markers in treatment decisions.
Iyengar's laboratory also has been looking at congenital and drug-induced
arrhythmias. Using genes identified as being related to long-QT (LQT) syndrome,
he and his colleagues built a disease gene network to see how the genes are
related. From a very large network of 15,000 nodes and 70,000 interactions, they
identified an LQT gene "neighborhood" of about 1,400 nodes. They found that
unique networks can be constructed around genes involved in disease states, and
the properties of these networks can help explain some of the characteristics of
different states.
Iyengar said that these networks also can explain drug side effects because
there is a relationship between the genomics and systems pharmacology of
LQT syndrome. Networks of biomarkers are likely to perform better than single
biomarkers for complex diseases because networks across genes integrate mul-
tiple sources of information. In this way, systems biology approaches can provide
insight into the pathogenesis of adverse events and suggest alternative targets
for treatment. It may even be possible to predict clinical outcomes 2–5 years into
the future on the basis of information from cellular or molecular networks.
SOURCE: Iyengar, 2008.
OCR for page 58
fortable using it to make clinical decisions without knowing the mechanism
behind a response?
Several workshop participants responded that biomarkers can pro-
vide valuable information even when biological mechanisms are largely
unknown. At a fundamental level, Califf observed, many biological mecha-
nisms remain at least partly unknown. Woodcock stated that medicine is
conducted among many uncertainties, and reliable information that can
distinguish who is and is not at risk is an advance beyond not having such
information. Also, Woodcock pointed out that the discovery of predictive
biomarkers can lead to research on their reliability and on their association
with outcomes.
Bloom emphasized the importance of not interpreting the term "bio-
marker" too narrowly. A biomarker is a piece of information that can be
used correctly or incorrectly in making a decision or seeking additional
information. The term "biomarker" can even be misleading if it is inter-
preted as denoting a single measurement without a broader biological
DEALING WITH DIFFERENT LEvELS OF RISk
Bloomfield described a hypothetical scenario involving a drug that is
effective at treating depression but causes a mean blood pressure rise of
2 millimeters (mm) of mercury in a test treatment population. Should such
a drug be approved? The ultimate question in such cases, he said, is the level
of risk that patients, physicians, and society are willing to accept.
Woodcock emphasized the complexity of this issue. The older anti-
psychotics, for example, posed major risks, but at one point they were
the only available treatments, so they were widely used. Regulators know
that a 2 mm rise in blood pressure will translate to a mortality difference
if a drug that causes it is used long enough. In the past, calculations of
risks and benefits were left largely to physicians and patients; today, other
groups play a role in these calculations as well. This is one example of how
biomarkers could be pivotal. If it were possible to identify subgroups who
would experience the 2 mm rise in blood pressure or would have a good
response to the antidepressant, the risk/benefit calculation would be easier
to make.
Califf suggested that an effective drug for depression would save lives,
and therefore should be available on the market. At the same time, how-
ever, an outcome study should be done to determine the true effect of the
drug on the balance of risk and benefit. The more biomarkers that can be
identified to gauge the effects of a drug, the stronger the signal will be as
long as the research reflects an awareness of the complex methodology that
must be applied to understand the joint effects of multiple markers. Iyengar
OCR for page 58
pointed out that most predictions take the form of probabilities, which do
not tell a patient or physician exactly what to do, and proper decisions will
be more likely if all parties involved understand the role of probabilities in
decision making.
Insel proposed a promising way to involve the public in the biomedical
enterprise and inform them about its results. He suggested that every
patient should become a partner in a research program addressing the con-
dition affecting that patient. This has already happened in some areas, such
as cystic fibrosis and particular kinds of childhood cancer. It could occur
as well for much broader groups, such as everyone with cardiovascular
Califf responded by saying that one of the most encouraging aspects
of establishing the David Murdock Research Institute is that the organizers
have been overwhelmed by calls from people in the surrounding region who
want to be enrolled in epidemiological studies. Involving these volunteers
in research will take careful planning, but they represent a largely untapped
resource that could speed the pace of scientific progress.
Iyengar, R. 2008. Systems biology of biomarker sets. Speaker presentation at the Institute of
Medicine Workshop on Assessing and Accelerating Development of Biomarkers for Drug
Safety, October 24, Washington, DC.


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It's actually a good idea to know how to induce menstruation if you have trouble with a regular period. It might seem like a blessing to not have to have a period as often as usual, but it can actually lead to cancer in the long run, because the uterus ends up getting damaged from too much tissue buildup.
The article writer is definitely right that you should go and see a doctor or nurse about any issues you're having with your periods before you try to treat them yourself, as you probably have an underlying issue.


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Kitchen Workhorse Roast Pork Tenderloin with Asian Glaze
From O at Home
Pork tenderloin can be found in every supermarket, usually packed two tenderloins to a package. That's a fair amount of meat for one meal, so you might as well face the music and roast both tenderloins. Use the sliced cooked meat in other dishes later in the week. What a perfect opportunity for an unexpected, extra meal! With this simple wet rub of Asian ingredients, the pork will be ready for the oven in no time.
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Nutritional Information
(per serving)
Calories | -- |
Total Fat | -- |
Saturated Fat | -- |
Cholesterol | -- |
Sodium | -- |
Total Carbohydrate | -- |
Dietary Fiber | -- |
Sugars | -- |
Protein | -- |
Calcium | -- |
Illustration by Michael Toland
Serves: 10
Oven Temp: 400
U.S. | Metric | Conversion chart |
- 2 tablespoon(s) soy sauce
- 2 tablespoon(s) light brown sugar
- 1 tablespoon(s) peeled and minced fresh ginger
- 2 teaspoon(s) dark Asian sesame oil
- 2 clove(s) garlic, crushed through a press
- 1/4 teaspoon(s) crushed hot red pepper flakes
- 2 pork tenderloins, trimmed of excess fat and any thin silver skin
- 1 scallion (white and green parts), thinly sliced, for garnish
- Position a rack in the center of the oven and preheat to 400 degrees. Line a small roasting pan with aluminum foil and lightly oil the foil. This is important, because the glaze has a high sugar content and it will scorch during roasting.
- Meanwhile, combine the soy sauce, brown sugar, ginger, sesame oil, ginger, garlic and hot pepper flakes in a self-sealing plastic bag and mix to dissolve the sugar. Add the pork tenderloins and close the bag. Toss the meat in the bag to coat it with the marinade. Let stand at room temperature while the oven heats.
- Remove the pork tenderloins from the marinade, and place on the baking sheet. Drizzle about half of the marinade over the pork. Pour the remaining marinade into a small saucepan and add 2 tablespoons water; set aside.
- Roast for 15 minutes. Baste the pork with the marinade in the roasting pan. Continue roasting until an instant-read thermometer inserted in the center of the meat reads 150-155 degrees, about 25 minutes more. The marinade will eventually thicken and scorch, but the foil will protect the pan, so don't worry. Transfer the pork to a cutting board and let stand for 5 minutes.
- While the pork is resting, bring the reserved marinade in the saucepan to a boil over high heat. Cut the roast pork crosswise on a slight diagonal into thin slices, and arrange overlapping slices of the pork on a platter. Drizzle the hot marinade over the pork, sprinkle with the scallion, and serve immediately.
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If RiRi and Chris have a second chance at love — they must go to therapy TOGETHER, an expert tells HollywoodLife.com. Read on for more details!
Now that Rihanna has publicly admitted she's still in love with Chris Brown – what's next? Many are expecting the two to get back together, but an expert tells HollywoodLife.com they need to seek help professional together before that happens.
"If they were to get back together again, they should go to counseling together and share the lessons they've learned with the public," Dr. Ava Cadell, Founder of Loveology University, tells HollywoodLife.com.
"They could be a powerful role model couple for others who have experienced similar abusive relationships," she tells us.
In addition to going to therapy together, Rihanna must also be fully aware of the warning signs of a batterer.
"She should be aware of the warning signs of an abusive man and unhealthy relationship. Some women find comfort in repetitive patterns even if they are destructive, so it's important for Rihanna to empower herself and let her female fans know that she will never be a victim of domestic violence again," Dr. Ava Cadell tell us.
What do YOU think, HollywoodLifers? Do YOU think Rihanna and Chris should get back together?
More Rihanna:
- Courageous Rihanna Went Public With Chris Brown Love Despite Huge Risks
- Chris Brown After Rihanna Interview: We'll Get Back Together
- Rihanna Parties In Tokyo While Her Emotional Oprah Interview Airs
View Comment
Posted at 12:52 PM on August 21, 2012
Posted at 4:15 PM on August 21, 2012
OMG I was thinking the same thing. I had never really paid attention to Rihanna before–not a fan; but while watching the interview I thought wow, her and CB would make some cute babies–just out of the blue. Glad I am not the only one who had that thought. Anyway, of course I don't 'know' them but from one human being to another I wish them both the best and if THEY decide to get back together I will surely be on baby watch for the little cutie.


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American Medical Association, Charles Schwab & Co., Colgate Oral Pharmaceuticals, FedEx, General Electric, Hewlett-Packard, Honeywell, Merck, NEC Solutions, Panasonic, Schlumberger, Sony, The Gillette Company, etc.
Seattle Software Corporation is headquartered at:
6523 California Avenue Southwest, #434
Seattle, WA 98136
Ph.: 206.286.7677
Email: firstname.lastname@example.com
Web: www.seattlesoftware.com
ShowGo is a registered trademark of Seattle Software Corporation.


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reader's bug
There's been a new bug identified that could be game-stopping in the very rare and not-very-probable instance when the player doesn't "look" at the driver's license before visiting dr Mulkin.
The updated version (1.3) will be up in several hours.
Saved games will work.
EDIT: Version 1.3 awaits you to the right.
16 Responses to "reader's bug"
co to ma znaczyc, tego sie nie da wybaczyc
:) tak wogole to gratulacje ze skonczenie dlugodystansowego projektu :)
How do you pass the first man with the machine gun ??
Use your vampire skill on him. Remember, as a vampire you need to replenish your blood supplies regularly.
Great game, thank you. I was a bit surprised that the roadmap had French street names – why that?
(oh and there are two endings, right? or did I miss a third one?) -
The game is a masterpiece. Ive finished it and i think Ive watched all the endings. I am not sure if there is a happy ending. They do make perfect sense, though. Brilliant game! As a fun of Gabriel Knight series, I find the puzzles, story and characters most interesting. Love your work!
Hi all, this game is simply gr8! is there any complete walkthrough? I can't bite anyone in the park no matter what I try with a cord or where I hide. Also no idea how to get money – have 0 now and a screwdriver, bible? Thanks!
I must say, when I started the game I was a little hesitant of the "live action cutout" artwork of the game, as I've seen that style execute poorly alot. When I landed in the alley after the intro, I became frustrated at the steep learning curve of the game's first interactions. The vampire skills might have been better placed as a side bar to the main actions instead of behind the inventory, but once I figured out where they were and what they did, it was fine. Certain sequences such as the vagrant dropping the paper in the trash could have done with a little more indication (pop up text), as the art style limits the ability to actually see what is going on. Now, with that said, the game itself is great! It had me playing and wondering what was coming next all the way to the end, although the love interest seemed a bit sudden and forced, the story line overall was engaging and flowed well from night to night. And yes, it reminded me alot of Gabriel Knight, which is a good thing in my mind.


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City of Fullerton
Public Information Office
303 W. Commonwealth
Fullerton, CA 92832
Phone: (714) 738-6317
Subject :
"Wild and Wacky Musical Patents" at Fullerton Museum
Contact :
Fullerton Museum Center (714) 738-6545
Fullerton City Manager's Office (714) 738-6317
Fullerton, Ca – "Wild and Wacky Musical Patents" is the theme of the next program at the Fullerton Museum, Thursday, March 7 at 7:00 pm.
Hosted by Richard Smith, curator of the Fullerton Museum Center, some of the more nostalgic musical instruments to grace a concert stage will be introduced, including early guitars from Vivi-Tone, Electro String and National/Dobro. Leo Fender, Fullerton hometown hero, had a few clunkers as well which will be discussed.
"Wild and Wacky Musical Patents" is free with a Museum Admissions. The award-winning Fullerton Museum Center, named the "Outstanding Arts Organization" by Arts Orange County, is located at 301 N. Pomona, east of Harbor, in downtown Fullerton. Museum hours are noon-4 p.m. Tuesday, Wednesday, Friday, Saturday and Sunday, and noon – 8 p.m. Thursday.
Admission is $4 for adults, $3 for students with student identification and senior citizens 65 and older, $1 for children 6 to 12, and free to children under 5 and to members of the Fullerton Museum Center. Admission is $1 for all visitors from 4-8 p.m. the first Thursday of each month.
Further information about the exhibit may be obtained by calling the Fullerton Museum Center at (714) 738-6545.
Persons requiring special accommodations to view the exhibit are asked to notify the museum staff prior to coming to the Fullerton Museum Center.


text: The full day eco-tour was customized to our needs. It was the best part of our Okinawa trip. We were blessed with sunny weather. Koko and Jun are experienced and caring guides. As Koko spoke good english, I was spared the job of translating for my friends. We enjoyed every moment. Even a simple lunch brought us so much fun,... More


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Crooked I - Gangsta Gumbo
Gangsta Gumbo Crooked I
Editor Rating: VERY HOTTTTT
User Rating:
Listen to Gangsta Gumbo, a new offering from Crooked I, which was released on Friday, July 9th, 2010.
Stream Gangsta Gumbo, the newest drop from Crooked I. The cut was released on Friday, July 9th, 2010. Crooked I continues to impress with each new leak, and Gangsta Gumbo is no exception. It's strengthens Crooked I's already impressive body of work, which has seen positive change over the years. We're most definitely anticipating Crooked I's next offering.
Have you heard Crooked I's Everythang? If you're down, make sure to visit Crooked I's profile page for the newest info, news, songs, and mixtapes.


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The below warranty information applies to purchases within the United States only.
Money Back Guarantee / Refunds
If for any reason you are not completely satisfied with your NuFACE device or attachment purchase from www.myNuFACE.com, simply return it within 60 days and we will be happy to credit your account for the full amount of the purchase price. NuFACE Primers and Skin Care can be returned within 30 days. Please call 888-360-9171 or email us at email@example.com for return information.
All Refreshed NuFACE kits are FINAL SALE.
We are only able to issue refunds for NuFACE products purchased directly from www.myNuFACE.com. If purchased from another retailer, please contact them directly for information on their return policy.
Please retain your proof of purchase as it is required for all refunds and returns.
At Carol Cole Company, we strongly believe in product quality and in our quality assurance processes. The Carol Cole Company manufactures within Good Manufacturing Practices (GMP). Every device is subjected to rigorous design, manufacture, inspection and test procedures to ensure it meets our exact specifications. Defective product is extremely rare. We do, however, examine every returned product to help us identify product and/or process improvements.
Every device includes a 60-day money-back guarantee and a one (1) year warranty covering any manufacturer related problems resulting from everyday use of the product. An extended 2-year warranty is available for purchase (must be purchased before original one-year warranty has expired) by contacting a representative at (888) 360-9171.
Please note that Carol Cole Company does not offer warranty replacements/repairs on the following:
- Products purchased, new or used, from unauthorized distributors or through unauthorized distribution channels. Note: Please call NuFACE to verify the full list of unauthorized retailers.
- Products purchased more than one year ago (unless an extended warranty was purchased)
- Packages missing hardware components
- Products returned without a valid itemized receipt or copy of a bank statement
- Damages due to misuse, improper maintenance or repair, using alternate voltage source, or unauthorized modifications
If you have any questions or concerns, please contact our customer service department at (888) 360-9171.
Please retain your proof of purchase as it is required for all refunds and returns.
Returns, Repairs and Replacements
If you believe your device is defective please contact our customer service representatives at (888) 360-9171 or firstname.lastname@example.com for troubleshooting. If it is determined that your device needs repair or replacement, our customer service representatives will provide you with the necessary information regarding the warranty replacement/repair process.
Please allow 7-14 business days for testing and shipment of replacement/repaired device. If your device is received in working condition, it will be shipped back to you as is.
Please retain your proof of purchase as it is required for all refunds and returns.


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The Fort Wayne Journal Gazette threw its own report in the buyout fray regarding the buyout for Notre Dame head coach Charlie Weis stating that the number is around $12 million.
The Journal Gazette has learned from a source close to the situation that Notre Dame coach Charlie Weis' buyout is at least $12 million.
The source said Weis is scheduled to be paid at least $2 million per year before incentives, which the fourth-year coach has not reached, according to the source. Weis agreed to the new contract in October 2005, soon after Notre Dame had a close loss to then-No. 1 USC, 34-31, in South Bend after reported NFL suitors came calling.
In the past few days there have been numerous rerports about the buyout. The Chicago Tribune said on Wednesday that the buyout figure was between $4-5 million. ESPN responded with a report of their own stating that the buyout was "stupifying" and around $16 million. Yesterday, Irish Illustrated reported the number to be around $10 million.
So what have we learned about Weis's buyout in the last week? No one really knows what the figure is and we likely won't ever know what the real value of the buyout is even if a change gets made.
Comments to this Article
JC commented on November 30th, 2008 at 10:20 am
All we know for sure is a vote of confidence not yet announced.
j sullivan commented on November 30th, 2008 at 11:52 am
it's despicable to see how every N D hater is gushing w/ delight over thr c w con-troversy…..i hope the n d admin. brings this to a an end and has the good judgment in hiring cw's successor
Castine commented on November 30th, 2008 at 4:50 pm
Why is a vote of confidence needed? For you? CW is ND's coach. A new coach would set this program back another 2-3 years. With a third consecutive excellent class coming to ND why risk the defection of many excellent recruits.
bleednd82 commented on November 30th, 2008 at 5:37 pm
Its sad, its not the ND haters that is the problem. I believe its the fan base. I am ashamed of my student body for throwing snow balls at my team. Is it a big deal no, but it shows how disrespect has set in and they dont even care. That is sad. I am for CW getting a 5th year. I am going to start calling "so called fans" haters soon.
We have a bowl game to go to. Who do we play and how do we win is what we should be talking about. Thats it.
JC commented on November 30th, 2008 at 6:06 pm
Well, first of all it's not my decision. The AD and Father Jenkins will make the call. By design, you have to pass an annual performance appraisal to continue. (So do all the coaches) The contract does have minimum performance requirements. And that judgement again, is reserved for the powers in charge.
Second, A week from now we will know the answer.
Third, generally when a coach is coming back they get a vote of confidence from the AD. Not a week later.
But, that again is the AD's wishes. He deserves to do the evaulation on his terms not the pundit's or fans. That is what he is hired to do.Lastly, I have been a Weis fan, however, John Cooper, Ohio State's previous coach said: "In this business you always have to keep your bags packed." Better yet a 5X5 guarantee: five feet or five seconds which ever comes first with our fickle fans.
Think about the reality of it when a prominent Alum say's his buyout was "loose change." He has the wrong people upset with him. So it's up in the air until we hear different, and Yes, he is the coach for now.
dan commented on December 1st, 2008 at 1:19 pm
i support the irish no matter what but this program just keeps hitting new lows. I like charlie and his personality. If charlie stays they need to bring a new line coach for sure
Little iRchard commented on December 1st, 2008 at 3:52 pm
Weis should be required to explain his inability to coach a football team. I've seen mediocrity but when a head coach hides his lips to call a play,35 points behind and less than two minutes to go(so the defence can't take advantage)something is WRONG
RVL commented on December 1st, 2008 at 4:04 pm
Hire Phil Fulmer.
Phil Oliver commented on December 2nd, 2008 at 3:00 pm
A coach will coach and a player will play. What could CW possibly be saying to the next batch of blue chip players about the success of the ND coaching staff. If I were a blue chipper (or parent of one) and had other options and based on the current ND direction! See Ya!!!! Can't blame em' Mom and Dad


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Bruno Mars Announces 'The Moonshine Jungle World Tour'
Looks like Bruno Mars will be taking crowds to the stars night after night this year!
Vote In Round 2 for Your Favorite RnB Diva, Here!
On February 11th, professional crooner, Bruno Mars, tweeted, "That's It! We're Goin On Tour!" with the follow up tweet:
— Bruno Mars (@BrunoMars) February 12, 2013
Mars has been celebrating the success of his second album, "Unorthodox Jukebox," which saw its first single, "Locked Out of Heaven" peak at number 1 on the ;Billboard 100 charts. The 13 time Grammy nominated artist performed at this year's award show, alongside Rihanna, Sting, and Damian and Ziggy Marley for a tribute to the late Bob Marley.
Vote In Round 2 For Your Favorite Reality Show Judge, Here!
Dates and venues have yet to be released for the tour, but there's word that Ellie Goulding and Fitz and the Tantrums will be opening up for him at select stops. The tour will start in the US this Summer and move through the UK in the fall.


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@seag47 – I know that sesame oil is great for your hair. I started using it after my life as a beachgoer turned my locks dry and brittle.
Every summer, I spend months on the beach. My hair gets bleached out by the sun, and the ocean and pool water zap it of moisture. It is not a pretty sight.
I started putting sesame oil on my hair as a leave-in conditioner before going to the beach every day. It acts like a sunscreen, so my hair kept its color. It also is very moisturizing, and it kept pool chemicals from damaging my hair.


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Role of Cloud Entities: Cloud Computing Certification Training
As discussed in our previous post on Cloud Entities, there are several actors that participate in cloud computing services and these actors are termed as cloud entities. Typically there are five types of cloud entities that participate in different aspects of cloud computing. Let's take a look at the roles that these entities play in cloud computing.
Role of a Provider
Provider is typically an organization that makes services available for customers. Its roles in cloud computing are:
- Manages Infrastructure and Applications
- Allows access to Service over Internet
- Standardizes Resources
- Maintains SLA
- Tracks usage and bills customer
- Provides API, SDK
Role of a Consumer
A Consumer is an entity that intents to use the service from the provider to solve a business problem. Its roles in cloud computing are:
- Consumes services from the Provider
- Is billed for the usage of the service
- Configures the service based on the requirement
- Agrees to the SLA and terms & conditions of the provider
Role of a Broker
A Broker is an intermediary that works on the behalf of Cloud consumer to deal with the provider. Its roles in cloud computing are:
- Works with multiple providers
- Assists in implementation of service for customer
- Abstracts service complexity
- Negotiates pricing
Role of an Auditor
An Auditor is an entity that examines the cloud service to verify its standard regulations and practices. Its roles in cloud computing are:
- Assess the providers
- Ensures commitment to SLA
- Protects the consumer
- Enforces standards and regulations
- Tracks the maturity of providers
Role of a Carrier
A Carrier manages the connectivity between the provider and consumer. Its roles in cloud computing are:
- Ensures last mile connectivity
- Maintains the transport channel for services
- Ensures service throughput
- Ensures availability
To know more about cloud entities, you can explore our training courses on cloud computing. Simplilearn provides both online and classroom training course on Cloud Computing.


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your initial deposit *subject to change and depends on individual circumstances.
RBC provides personal and commercial banking, wealth management services, insurance, corporate, investment banking and transaction processing services on a global basis.
Recent Sector News
UPDATE - Lloyds to resume divi payments despite PPI problems
State-backed lender Lloyds Banking Group will pay out a dividend to shareholders for the first time since 2008.
RBS suffers another loss on US write-down
A £4bn write-down in the US has led state-owned lender RBS to report a seventh consecutive full-year loss.
RBS and Lloyds scrape through stress tests but the Co-op fails
The Co-operative Bank has failed the Bank of England's stress tests, while Lloyds and Royal Bank of Scotland scraped through.
Banks under the microscope after Northern Rock's £258mln High Court loss
Early gains in the banking sector were wiped out by a landmark ruling that has opened up the compensation floodgates at what's left of Northern Rock.
RBS landed with huge fine for 2012 IT meltdown
Royal Bank of Scotland has been handed a £56mln fine for an IT meltdown that left nearly seven million customers frozen out of their accounts.
Royal Bank of Scotland to keep Ulster Bank in the fold as things improve
Profits improve at the state-owned bank but so do provisions for potential costs related to PPI mis-selling and FX manipulation.
Lloyds Banking Group to axe 9,000 jobs and shut 150 branches
Job cuts are on the way at Lloyds after a strategc review of the business while the bank's interim management statement pointedly made no mention of when the company is likely to return to paying dividends.
Royal Bank of Scotland says bad debts picture is improving
RBS's Capital Resolution division may emerge from the nightmare of asset impairments a lot sooner than it anticipated.
Royal Bank of Scotland to raise US$3bn+ from Citizens Financial flotation
RBS is planning to sell 140mln Citizens shares at a price somewhere in the range of US$23 and US$25, inclusive.
Secure Trust Bank eyes SME opportunities
As names go, Secure Trust Bank is a hard one to beat for a banking organisation. if it sounds a bit old fashioned, that could be because it operates like a traditional lender, not a casino.
Lloyds Banking: government rules out retail offer this year
George Osborne has ruled out the sale of the government's Lloyds Banking stake to the public in 2014 but further sales to institutional investors are still possible.
RBS boosted by 'bad bank' being not so bad after all
Shares in taxpayer owned RBS shot up in early deals as it took the market off-guard by releasing first half numbers a week early.
Big four banks face competition probe after failing customers
Watchdog rejects offer of comparison website and goes for full enquiry to address major barriers to entry.
UPDATE - Barclays shares sink as lawsuit filed over its "dark pool"
Banking behemoth Barclays has once again been accused of behaving badly - as a New York lawsuit has been filed against it.
TSB shares race to healthy premium amid strong demand
Demand has been high for TSB shares and today's float sees Lloyds sell 35% of the retail bank - rather than the originally planned 25%.
UPDATE - TSB float answers doubters as shares zoom to premium
Newly floated TSB shares zoomed to an early premium Friday, rising to 285.5p from a list price of 260p. The near 10% increase in early deals comes after strong demand reported by Lloyds for the latest London IPO.
TSB share sale rumoured to be better than expected
Details of the retail banking IPO are due tomorrow but reports suggest that Lloyds may be selling a larger stake in the unit, with the Government backed banking group selling a 35% stake rather than 25%.
Any TSB takers must act soon
Any takers for shares in Lloyds spin out TSB must act quickly as the deadline is today (June 17).
UPDATE - Lloyds unveils cut price TSB float
Priced below the bank's book-value the TSB IPO is ether a bargain or it's a sign that appetite for new stock market floats is waning.
UPDATE - Lloyds unveils TSB float amid cooling appetite for London listings
Part taxpayer-owned bank Lloyds Banking Group will float TSB bank amid the apparent cooling appetite for London listings.
HSBC sees first quarter revenues and profits tumble
Profits and revenues were down in the first quarter at HSBC, though the banking giant said last year's performance was boosted by a number of one-off items.
Lloyds Banking and the new Portguese "special one"
It is back to the future this year for Lloyds Banking Group as it prepares to downsize and resume paying dividends.
Lloyds Banking Group gearing up for TSB float
Lloyds Banking Group plans to float TSB in the next eight weeks, with 25% of the business expected to go on sale.
UPDATE - Barclays chairman Walker issues staunch defence of bonuses despite profit warning
Barclays chairman Sir David Walker has defended the bank's decision to pay its investment banking staff substantial bonuses despite revealing a profit warning from the struggling division.
Goldman Sachs says Dragon Oil is "attractive opportunity" as it upgrades to 'buy'
"We believe the recent share price weakness creates an attractive opportunity in a stock with compelling free cash flow and dividend yields going forward," analyst Ruth Brooker said in a note.
Lloyds falls 4.5% as UK Govt sells £4.2bn of shares
About 5.5bn Lloyds shares are being sold at a price of 75.5p, a 4.5% discount to Tuesday's close. As a result the Treasury's stake in the bailed-out bank drops to 23.8%.
RBS's additional provisions will not be enough, Nomura says
The timing of Monday's trading update from Royal Bank of Scotland may have surprised the market, but the decision by new CEO, Ross McEwan, to go down the 'kitchen sink' route and make another £2.9bn of provisions related to "past conduct issues" did not.
Lloyds Banking hit with £28mln bonus scheme fine
UK government controlled bank hit with biggest ever retail failings fine after incentive schemes forced staff into a frenzy of selling.
RBS hit with new rate rigging fine but Barclays let off
European Commission levies fines of €1.7bn. RBS to pay €391mln but whistleblowers Barclays and UBS excused.
Barclays reportedly suspends six FX traders
The investigation into foreign exchange markets manipulation appears to be intensifying, with reports that Barclays has suspended six traders.


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Home > Faculty Programs & Resources > Simulation and Technology
Simulation and Technology
In today's technology-rich environment, nurse educators need to be up-to-date on the latest innovations in simulation, e-learning, telehealth, and the integration of informatics into curricula. To promote professional development in this area, the NLN offers a variety of sophisticated resources and activities.
About the NLN | Certification for Nurse Educators | Faculty Programs & Resources | Membership Information | Public Policy NLN Publications | Recognition Programs | Research & Grants | Testing Services | Careers
The Watergate | 2600 Virginia Avenue, NW | Eighth floor | Washington, DC 20037 | 800-669-1656 Copyright © 2013 National League for Nursing The Voice for Nursing Education


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Anyone know of a good Optimator clone AG recipe? I searched, but haven't been able to find much... thx!
okay, maybe I'll try this -- any thoughts?Recipe: Optimator Ale but i'll convert the LME to grains...
I shot out a thread some time ago on this and got some feed back. Not a lot but when I have an extra min, I will direct you to my thread. I gotta go get my kids from school. I will be back in 30 min or so. Cheers JJ
I will check my many sources for clone recipes when I get home to see if any of them have one... "radio edit" sorry, nothing in any of my clone books or magazines...
I've got Jamils Mr. Maltinator sitting in my lagerator right now. Made it up back in July. It's still thinking about its self, but snuck samples taste pretty goot. Still a little hot right now. First doppelbock I've made so not sure if this is right or not. Had the fermentation right on at 50F for about 3 weeks then upped it to 65F for week or so and then stuck it in the lagerator.
Ender I'm Smelling a lot of IF coming offa this plan
like to revive an old thread, the spaten website said the OG is 1.076, and being a 7.2% ABV beer, that would put the finishing gravity at 1.021.
Yeah, any updates on successes on this one? I love a good doppelbock, it'd be fun to get an Optimator going.
I realize this is old but has anyone ever found a good recipe? Ender, how did yours finally turn out in comparison to the original?


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Kahaluu, HI Lawyers and Law Firms
Kahaluu, Hawaii Attorneys
William H. Lawson, Attorney at Law
Honolulu Hawaii Personal Injury and Accident Attorney
(808) 528-2525William H. Lawson, Attorney at Law is a personal injury attorney in Honolulu, Hawaii who has been handling personal injury matters for over 3 decades. Mr. Lawson handles all kinds of personal injury claims, including auto accidents, trucking accidents, motorcycle accidents, products liability,...
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Lynnae Lee & Associates
Family & Divorce Attorneys in Honolulu, Hawaii
(808) 237-4100Lynnae Lee and Associates, located in Honolulu, Hawaii, focus on serving families in need of legal counsel on a wide range of issues. Whether you are considering adoption, writing a will, purchasing real estate or facing the pain of divorce, Lynnae Lee and Associates has the expertise and...
Law Firm's Overview Free Consultation
Todd Eddins, Attorney at Law
Honolulu, Hawaii Criminal Defense Attorney
(808) 538-1110Todd Eddins, attorney at law has given over two decades of powerful legal experience and compassion to Hawaii residents facing the devastation of criminal charges. Attorney Eddins has a lifelong resident's knowledge of Hawaii's courts, legal customs, and peoples, and has used his firm and expertise...
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Law Offices of David W. Barlow, LLLC
Honolulu, Hawaii Personal Injury and Auto Accidents Lawyers
(808) 692-0616The Law Offices of David W. Barlow, LLLC is a Hawaii personal injury law firm with offices in Downtown Honolulu and in West Oahu. If you or a loved one has been injured because of someone else's fault, you have the right to fair compensation for your injuries. With aggressive representation, we...
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Craig W. Polanzi, Attorney at Law
Divorce and Family Lawyer in Aiea, Hawaii
(808) 664-1456The Law Office of Craig W. Polanzi is a bankruptcy and family law firm in Honolulu, Hawaii. Our goal is to support families through the life-changing decisions related to severe debt, divorce, and other stressful situations. We take our clients' personal needs seriously, and will work closely with...
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Myles S. Breiner, Attorney at Law
Honolulu, Hawaii Criminal Defense Lawyer
(808) 526-3426Myles S. Breiner, Attorney At Law, A Law Corporation, Inc., has been in service defending Hawaiians for over 25 years, litigating for civil rights, families, the injured, and the accused.
I have spent most of my career working as both a prosecutor and defense lawyer in Hawaii. My years as a...
Law Firm's Overview
Cronin, Fried, Sekiya, Kekina & Fairbanks
Auto Accident Law Firm in Honolulu, Hawaii
(808) 524-1433Cronin, Fried, Sekiya, Kekina and Fairbanks, Attorneys at Law is a prominent Honolulu based personal injury firm, serving auto accident clients throughout Hawaii. The firm's award-winning legal team is dedicated to providing their clients with the highest quality legal representation possible, and...
Law Firm's Overview Free ConsultationContingency Fee
Sheila Vierra, Attorney At Law, LLLC
Honolulu, Hawaii Divorce Law Firm
(888) 594-6082Sheila Verra, Attorney At Law LLLC in Honolulu, specializes in family law. The practice offers a full-range of services regarding issues relating to families. The law firm is one of the few practices that can prepare and process domestic relations orders, which allows people the right to be given...
Law Firm's Overview
Richard Paul McClellan III Lawyer
Tax Defense and Criminal Tax Defense Law Firm in Honolulu, Hawaii
(808) 523-0449Richard Paul McClellan III is a tax defense attorney based out of Honolulu, Hawaii providing legal services and representation to clients throughout the surrounding areas of Hawaii, as well as select cases in mainland US tax courts. Mr. McClellan has extensive expertise handling matters of tax...
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Davis Levin Livingston
Personal Injury, Accident & Malpractice Attorneys in Honolulu, Hawaii
(808) 450-3004 or (877) 764-8595Davis Levin Livingston is a personal injury law firm located in Honolulu, Hawaii specializing in auto accidents and medical malpractice. The lawyers of the firm dedicate themselves to the betterment of clients' lives through devoted advocacy and an empathy that carries clients from start to finish...
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Shim & Chang, Attorneys at Law
Injury Attorneys in Hawaii
(808) 524-5803Shim & Chang, Attorneys at Law, A Law Corporation is a group of skilled personal injury lawyers in Honolulu, Hawaii that represents clients with a broad spectrum of claims. The attorneys of the firm know the area, and they are experienced in maritime, helicopter and tourist claims. They know...
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Leavitt Yamane & Soldner
Honolulu, Hawaii Personal Injury Lawyers
(808) 537-2525 or (877) 521-7474Leavitt, Yamane, & Soldner is a Honolulu, Hawaii personal injury law firm that represents clients in a wide range of claims. The lawyers of the firm demonstrate an unwavering commitment to providing personalized service that helps clients feel comfortable. An attorney will work with you...
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Law Office of Sara R. Harvey
Kailua, Hawaii Divorce and Family Attorney
(866) 637-1598The Honolulu Law Office of Sara R. Harvey is located in Kailua, Hawaii and specializes in all aspects of family law. Attorney Sara Harvey has more than 25 years of legal experience handling divorces and helping families navigate through difficult times. Our clients range from Oahu throughout all of...
Law Firm's Overview
Shawn Luiz, Attorney at Law
Honolulu, Hawaii Employment and Criminal Lawyer
(808) 538-0500Shawn A. Luiz, Attorney at Law is based in Honolulu, Hawaii and specializes in employment law, criminal law and civil law. The goal of our firm is to protect the rights of our clients, whether that means protecting your civil liberties or defending those who have been wronged in the workplace, we...
Law Firm's Overview
The Law Offices of KahBo Dye-Chiew
Honolulu, Hawaii Immigration Attorney
(866) 510-7082At The Law Offices of KahBo Dye-Chiew in Honolulu, Hawaii, we strive for excellence in providing help with all aspects of immigration. Our immigration services are offered to not only individuals, but to small and large businesses, who desire to work or live in the United States. We offer...
Law Firm's Overview
Affinity Law Group, LLLC
Hawaii Bankruptcy, Foreclosure, Business Formation & Estate Planning Attorneys
(808) 545-4600At the Affinity Law Group, our attorneys realize the hardships those who file for bankruptcy experience and offer legal advice and help with Chapter 7, 11, and 13 bankruptcy, foreclosure, and debt collection to individuals and businesses.
Our lawyers can explain the various aspects of bankruptcy...
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Alston Hunt Floyd & Ing
Business and Real State Law Firm in Hawaii
(808) 524-1800Alston Hunt Floyd & Ing (AHFI) is an experienced, dedicated law firm serving clients in Hawaii. Our firm is known for providing high quality, fast, creative and cost-effective service. We do not try to be "all things to all people." If we cannot provide you with the highest quality of legal...
Law Firm's Overview
Bays Lung Rose & Holma
Commercial Litigation Law Firm in Honolulu, Hawaii
(808) 523-9000Bays Lung Rose & Holma was established in 1986 by a group of experienced attorneys to offer a unique level of expertise in real estate and construction law. We had firm goals in mind: An aggressive spirit, a systematic and logical approach, and a client-first attitude. Since then, the firm has...
Law Firm's Overview
Char Hamilton Yoshida & Shimomoto
Honolulu, Hawaii Family, Insurance and Business Law Attorneys
(877) 234-9119Char Hamilton Campbell & Yoshida is a Honolulu, Hawaii law firm representing clients in family law, captive insurance, workers' compensation, estate planning, and business planning matters throughout Hawaii, California, Nevada, Arizona, the District of Columbia, and outside of the United States...
Law Firm's Overview
Charles H. Brower and Associates, ALC
Honolulu Civil Litigation Lawyers
(808) 526-2688Charles H. Brower and Associates, ALC handles a wide variety of personal injury and wrongful death matters, including cases involving automobile accidents. The firm provides experienced and compassionate legal representation to clients in Honolulu and throughout Hawaii who have been injured or lost...
Law Firm's Overview Free Consultation
Cronin, Fried, Sekiya, Kekina & Fairbanks
Hawaii Personal Injury Lawyers
(808) 524-1433 or (800) 227-8601Cronin, Fried, Sekiya, Kekina & Fairbanks, based in Honolulu, is the preeminent personal injury firm in Hawaii. Since opening in 1973, we have recovered hundreds of millions of dollars in high profile cases on behalf of a wide range of catastrophic injury victims and their families.
Law Firm's Overview Free Consultation
Edmunds Verga & Omonaka
Hawaii Auto Accident Lawyers
(808) 524-2000The law firm of Edmunds Verga & Omonaka is a Honolulu-based firm representing businesses throughout Hawaii in a range of commercial and complex litigation. We also assist individuals in criminal defense proceedings and plaintiffs in personal injury claims involving auto accidents, boating or...
Law Firm's Overview Free Consultation
Harrison & Matsuoka, Attorneys at Law
Criminal Law Firm in Hawaii
(808) 523-7041Harrison & Matsuoka is a criminal defense law firm based in Honolulu, Hawaii. Our attorneys are on your side. We listen to you. Even when you believe you are guilty, we strive to get you the best possible resolution. Just say, "I want a lawyer" and call the offices of Harrison & Matsuoka as...
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Knotty Boy Dread Wax
Join the Conversation
RickNew YorkGreat Product... What Size Is Thi Jar??I know about the product. I personally won't use anything else regardless the contrary information about using dreadwaxes. I have only have good result & positive respones from people I meet who ask "who does your hair?". Me. "How much do you charge?....". My only question is: What size jar is this your selling? I can't find it! Please let me know ASAP. Awaiting your response before I buy it.Reply to this postDec 30, 2011Link to this post
Have a question or a tip to share?
If you'd like to hear more about how this product worked (or didn't) for people with hair like yours, take advantage of our network of experts and customers by posting a question. Or, if you've used the product and want to post a tip or advice, go for it.
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Knotty Boy All Natural Dreadlock Shampoo with Tea Tree, Rosemary and Peppermint oils.
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Designed for more mature dreadlocks, the all-natural (as always) Knotty Boy Dreadlock Conditioning Spray is a leave-in moisturizer.
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Who need I need to kill to get some honor!
View Single Post
Archived Post
Lt. Commander
Join Date: Dec 2007
Posts: 120
# 5
Originally Posted by
Everytime you hail the KDF there should be PvE/PvP missions availible. These missions for the most part are repeatable. The Kahless expanse mission is repeatible , although slightly bugged . Once you complete it 3 times and turn it in , it may well into the fourth time you're at it that it becomes availible again . Every time you turn in a mission you reciecve Honor . Medals come from PvP , Exploration medals come from doing the PvE specifically the kahless expanse , azure nebula , chos nebula etc.. content ad nauseum.
P.S : On the mini map it's the klingon symbol.
Can you even do Kahless after level 31?


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Featured Article
Many Latinos in the state are applauding President Obama's nomination of Sonia Sotomayor to the Supreme Court.
Before he was president of the Universal Health Care Foundation of Connecticut, Juan Figueroa led the Puerto Rican Legal Defense and Education Fund in New York City. There he says he met Judge Sotomayor. He describes her as a well-qualified judge whose life story adds an important dimension to the Supreme Court. "Here was have a jurist who comes from very humble beginnings. The daughter of Puerto Rican parents who migrated from Puerto Rico to New York …with a dad who as I understand it had only a 3rdgrade education"
Figueroa says she represents the Hispanic community – a group that's been missing for too long from nation's most prestigious bench. "This appointment is of huge significance in relation to having a Supreme Court that reflects the reality of the demographics and the fact that we are a country of.of hardworking immigrants that come here to get ahead…to forge an education for their kids and contribute to this country in so many ways."
Judge Sotomayor has several connections with Connecticut. She attended Yale Law School where she was editor of the law review. And one of her most high-profile decisions involves white firefighters from New Haven who were denied promotions because too few black firefighters scored high enough on an exam. New Haven threw out the results of the test and no one was promoted. The white firefighters sued. Sotomayor was one of three judges on a panel at the 2nd US Circuit Court of Appeals in NY that upheld New Haven's decision to scrap the test. That case is now before the U.S. Supreme Court.


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Contents |
Librarians' Travel Guide to Philadelphia
General sites, Maps, Public Transportation
Getting Around Conference Sites
Public transportation to/from the airport
Septa - Airport line
$6 each way. The train stops directly at the airport. Use the machine to buy your ticket before you board!! There's a surcharge if you pay on the train.
Local Media
Wireless access
Restaurants and other food options
Gianna's will excite the vegetarian, vegan, and carnivore alike. Famous for their Philly cheesesteaks. Also excellent sides and desserts. Not to be missed.
This little grocery store has excellent samosas. A worthwhile trip to University City.
This is a totally vegan restaurant and satisfies all your cravings for food you probably never thought you could again. From Shark Fin Soup to Won Ton to Sweet and Sour Chicken, KOV is phenomenal. I highly recommend the dim sum.
An excellent place just across the street from the conference center. You can buy groceries or a meal. It has Amish foods and various other kinds of food. Some of my favorite vendors are: Famous 4th Street Cookie Company, Nanee's Kitchen (Indian), Iovine's produce.
It has free wireless, but it is ALWAYS crowded!
Middle Eastern and American food (meaning, you can get both falafel and fries). Seriously the best falafel and baba ganoush this user has ever experienced.
Vietnam Restaurant 221 N. 11th St (near the convention center)
Kinda fancy, but not too expensive. Has several tofu options.
910 Christian Street (9th and Christian) Sabrina's is really crowded if you go for brunch, but not so bad for dinner. It's near the Italian Market, which is also worth checking out. For vegetarians, who might otherwise miss out on Philly cheesesteaks, Sabrina's has a great seitan version! The menu is kind of like classic American food with a twist. BYOB
Farmacia 15 S. 3rd St (3rd and Market) - about 7 blocks from the Convention Center
A little expensive, entrees cost $13-25. Several vegetarian options. It's the kind of place where even if you order something ordinary, the food is extra good.
3420 Sansom Street (34th and Sansom, near UPenn)
A little expensive, $16-25 entrees. There are usually only a few vegetarian options. Ingredients are mostly local, organic and seasonal. The owner is committed to social justice, and they host many community events. Very good!
221 Church Street (2nd and Church, a small street just north of Market)
In addition to being a terrific Ethiopian restaurant, Dahlak is a great bar. When I lived in Philly (2001), they also had a dynamite jukebox. In west Philly.
Libraries and Local bookstores
Giovanni's Room (GLBT)
345 South 12th Street (12th and Pine)
108 S. 13th Street (13th and Sansom)
508 South 5th Street
Record Stores
Vintage Shopping
Tourist attractions
Liberty Bell (map)