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Ignite Your Passion for Adventure
Once a mom, always a mom. And for most mothers I know, our children, newborn or newly married, rank right at the top of our priority list.
At the same time, many women put their own dreams, aspirations and needs firmly on hold to make sure their offspring thrive. While drowning in formula, car pool schedules or family bills and paperwork, it's easy to lose an otherwise healthy sense of adventure.
With or without children, it's easy to fall prey to the "Someday Syndrome". Someday, when the kids are grown, I'll climb a mountain, raft a river, join a volunteer vacation, or paint a landscape. Someday, when the kids are out of diapers, after soccer season, when I get a raise, we'll go on a cruise, pitch a tent, build a tree house or hike the Appalachian Trail.
I hope you will book mark this blog and return time and again as one way to reignite or simply maintain your enthusiasm for adventure. I will share my own stories and traveler's tales and the vibrant experiences of others. From time to time, I'll write about paring down the daily details, making space for exploration. And here, you'll also find news of great travel deals or hints about off the beaten path possibilities.
Together, we'll tap into a world of invigorating opportunities, many that lie just beyond the back door.
P.S. - I am leaving tomorrow on a road trip, so my next post will be from somewhere high in the Colorado Rockies!


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The American-Arab Anti-Discrimination Committee (ADC) is preparing for its 34th National Convention. This year the Convention will be held on Father's Day Weekend, June 12-15th. Please note that the Convention will take place at the Crystal Gate Marriott in Arlington, Virginia.
It truly does take a community to protect our rights and preserve our cultural heritage. Everyone has an important role to play. We hope that you will be able to join us at the 34th Annual Convention as we reflect on the current challenges that our community faces, and plan our strategies for overcoming these challenges in the future.
The collapse of the peace process brings into question the existing paradigm and invites us to think in new ways about the conflict and the way forward toward a just and lasting peace. "Paradigm Shift: New Thinking on Israel/Palestine" will feature speakers Jonathan Kuttab and Jeff Halper and will be moderated by Delinda C. Hanley.
Keynote speaker Saleh Abdel Jawad, presentation by Dr. Yusif Farasakh, Rachel Corrie Award presented to Ellen Siegel, special remarks by Dr. Abdulhadi Hantash, a guest from Hebron.

subset: commoncrawl


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MEDFORD, Ore. — The Medford School District is receiving a $500,000 elementary physical education grant. However, the grant still has to be approved by the Medford School Board.
Currently, only 10 of the 14 elementary schools qualify for the grant. Qualifying schools must have more than 40 percent of their enrolled students on free or reduced lunch plans.
According to Medford School Board president, Jeff Thomas, the board needs to discuss the grant and figure out a way to treat all of the elementary schools fairly. He said he does not want one school feeling less important than the others.
As of now, schools in the Medford School District do not have physical education teachers. Physical education is taught by a regular school teacher, but the grant will give the district the money to hire physical education teachers who will just teach P.E.
The grant will pay for their salary, but the district will still have to pay for their benefits. Education officials are expected to ask the school board on at their meeting Monday, September 16, for $300,000 to fund physical education staffing for the four schools who are not applicable for the grant, and benefits for the new physical education teachers who are hired as a result of the grant.
"We're still trying to work on the logistics to make this program happen, and figuring out how to serve the other schools now that we have this exciting amount of money being given to this district from this grant," said Julie Evans, Director of Elementary Education for the Medford School District.
The school board said they are unsure if they will approve the grant at the school board meeting on September 16.


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- dotTech - http://dottech.org -
Free RoboForm Pro! CC Required =( [1 month NetFlix trial code included also]
Posted By Ashraf On January 15, 2009 @ 4:34 PM In Freebies | 15 Comments
Most everyone has heard of RoboForm. If you have not, you are missing out. RoboForm is an excellent tool that saves your usernames, passwords, and other goodies (personal information) and allows…ugh I am just rambling. Lets hear it from the developer [1] themselves what RoboForm is:
RoboForm allows you to:
More propaganda for RoboForm:
Bottom line: RoboForm kicks ***. Most people already know that. Most people also know that there is a free version of RoboForm. However, that free version is limited, but still usable. Differences between Free and Pro are listed here [4].
So, interested yet? Ya, I was too when I heard about it =D. Okay, the bad news is that you need a credit card. The good news is that it is completely free and will take you literally 10 minutes. What we are going to do is use CheckoutFree.com (a company much like TrialPay.com) to enable use to get RoboForm Pro for free:
Click here [5] to access the CheckoutFree.com RoboForm Pro offer:
Click the "CheckoutFREE" blue button. You will then be prompted with this page:
Fill it out, be sure to enter a valid email address. Click "View Offers". You will be prompted with this page:
Pick any offer you want and sign up. Many are free, many are not. All of them require a valid credit card but you can cancel the offers that are trials before they charge you. I was gunna do NetFlix, but then I decided I would rather have 1 month free NetFlix* then the 2 weeks I would get via this offer, so I choose Stamps.com (4 weeks free trail + $5 free in stamps). Whatever offer you choose, be sure to use the same email address you entered earlier just to make sure nothing goes wrong. You have to fully complete an offer as described (most require you to sign up for something). After you are done signing up for an offer, check your email. You should have an email from "CheckoutFree.com <email@example.com>" with subject "Purchase Confirmation for RoboForm". The email will look like this:
Just follow on screen instructions from here on out and you will have RoboForm installed and activated within 5 minutes! I just did =)
Enjoy! =) Also note, you are not limited to just one CheckoutFree.com offer. If you see anymore, you can still do them. However, most vendors (the 'offers' you choose from) limit themselves to new customers, so you may have to choose a different offer next time you use a CheckoutFree.com deal.
*For 1 month free trial for NetFlix, use the promo code A80020935. New customers only. This promo code will not stack with CheackoutFree.com so be sure to sign up with NetFlix seperately by going to NetFlix.com. You must enter the promo code from the "Buy/Redeem Gift" link up top:
Article printed from dotTech: http://dottech.org
URL to article: http://dottech.org/2673/free-roboform-pro-cc-required/
URLs in this post:
[1] developer: http://www.roboform.com/
[2] CNET reviewer: http://www.download.com/RoboForm/3000-2092_4-10037672.html#editorsreview
[3] user reviews: http://www.download.com/RoboForm/3000-2092_4-10037672.html#userreview
[4] here: http://www.roboform.com/why-pro.html
[5] here: http://www.checkoutfree.com/checkout/?c=166edb404d76d21d
[6] Image: http://dottech.org/wp-content/uploads/2009/01/2009-01-15_150040.png
[7] Image: http://dottech.org/wp-content/uploads/2009/01/2009-01-15_150050.png
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[10] Image: http://dottech.org/wp-content/uploads/2009/01/2009-01-15_163202.png
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Click here to print.
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Ultra-portable bass cabinet with the technology and craftsmanship of Markbass. Order now.
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24 Quick and Easy Knitting Patterns
Bonus: Get our newsletter & special offers for free. We will not share or sell your email address. View our Privacy Policy
Cold Weather Knit Dickie
By: Bernat
A dickie warms your neck and shoulders in cold weather. Make one with this free knitting pattern for a warm and chunky but fashionable dickie from Bernat Yarns. With only two balls of yarn, this knitting pattern works up much quicker than a full sweater.
- Yarn: 2 balls of Bernat Alpaca (100 g / 3.5 oz) #93143 (Sky).
- Knitting Needles: Size 6 mm (U.S. 10) or size needed to obtain gauge.
15 sts and 20 rows = 4" 10 cm in stocking st.
Size: One size fits average adult.
Cast on 63 sts.
1st row: (WS). K3. *P2. K3. Rep from * to end of row.
2nd row: P3. *K2. P3. Rep from * to end of row.
Rep last 2 rows for 8" [20.5 cm], ending with 1st row.
1st row: (RS of Yoke). Knit, inc 1 st in center. 64 sts. Place markers on 17th, 33rd, 49th and 64th sts.
2nd and alt rows: Purl.
3rd row: *K1. yfwd. Knit to marked st. yfwd. Rep from * to last st. K1.
Rep last 2 rows to 46 sts between marked sts, ending with 3rd row.
Knit 2 rows even. Cast off knitwise.
Sew back seam, reversing first 4" [10 cm] for turn back.
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My mum had a pattern like this years ago. Have been looking for this sort of thing for ages. Thanks. GillianMc
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Snooki Reveals Baby Bump
Jersey Shore star tweets pregnancy photos
Mom-to-be Nicole "Snooki" Polizzi isn't letting a little pregnancy get in the way of her fashion sense.
The Jersey Shore star tweeted a couple of photos of her baby bump on Thursday. Glad in a little black dress, Snooki shows that she's showing.
"Love this photo," Snooki tweeted along with the photo. "Shows off my bump perfectly."
Previous reports suggest that Snooki and fiance Jionni LaValleare are expecting a baby girl. Snook hasn't confirmed the report. She's probably saving that for another magazine cover and paycheck. Snooki is due in September and said earlier this month that she couldn't be more excited.
"I can't wait to meet my kid!" Snooki said. "Everyone will be surprised to see a different side of me. I'm loving, caring, sensitive, protective and very maternal, no matter what people might think."


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Human Resources Department
- Location and Office Hours
- Employment at Blue Ridge Community College
- New Employee Orientation
- New Hire Forms and Documents
- Employee Benefits
- Quick Links for Faculty and Staff
- Contact Us
Location and Office Hours
The Human Resources Department is located on the Henderson County Campus on the first floor of the Patton Building, Room 120.
The Human Resouces Office is open Monday through Thursday, 8 a.m. to 5 p.m.; Friday, 8 a.m. to 4:30 p.m.
Employment at Blue Ridge Community College
Education and training needs are fluid and constantly changing. What was cutting edge technology ten or fifteen years ago, is today's history. Meeting and exceeding academic and training demands, yet not sacrificing a quality educational experience, means hiring motivated and qualified full-time and part-time faculty and staff members.
Blue Ridge Community College provides its employees with a meaningful employment experience. Full-time employees enjoy a competitive salary and benefits programs, while also receiving the opportunity to grow professionally in an academic environment.
Adjunct instructors also fill important academic and training roles at Blue Ridge. We have a continuing need for temporary and part-time instructors in both curriculum and continuing education programs.
Blue Ridge Community College does not accept unsolicited applications for full-time faculty and staff positions.
Blue Ridge Community College is an Equal Employment Opportunity Institution.
View all current employment opportunities
New Employee Orientation
The following link provides new employees a web-based orientation to Blue Ridge Community College.
New Hire Forms and Documents
- New Hire Checklist
- Personnel Data Form
- I-9 Employment Eligibility Verification
- W-4 Federal Tax Withholding
- NC-4 North Carolina Withholding
- NC-4EZ North Carolina Withholding
- ACA - MarketPlace Disclosure Statement
- Part-time Non-Instructional Staff Employment Agreement.
- TSR Terms and Conditions
- Direct Deposit Form
- Form ESRR - Certifying Employee Status Under Reemployment Laws
- Faculty Competency Form
Employee Benefits
- Employee Assistance Plan
- NC Retirement System
- NC State Health Plan
- NC State Health Plan Enrollment or Change Plan
- Supplemental Benefits Plan
Quick Links for Faculty and Staff
Contact Us
Phone: (828) 694-1741
Visit: Patton Building Room 120
Tommy Oakman, Director
Rebecca Blake, Technician


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When you're young, everything is also something else. An ordinary stone could be currency in your made up world, or a teepee made from moss may well be 'home base' for your action figures. Children have it best at this stage in life and this design is for them. The UNI-struct system is a nearly limitless space creation toy geared toward imaginative five to eight year-olds. It allows children to construct play areas of their own design, whether it be large-scale (e.g. a playhouse) or small (e.g. a mountainous environment for G.I. Joe ™) and build their minds and creativity in the process.
Three building bars, each with a different length and curvature, and a soft plush-covered weighted base, comprise the main components that supply the lightweight structure to their space. Each bar contains an ultra-strong neodymium magnet at one end which can connect to either end of another. The end of a bar without a magnet is designed to combine with others through friction when a magnet is not present, making every attachment truly universal and the need for specialized connectors obsolete. Bars are durable and have wide, soft rounded ends for safety. Options increase as a range of different fabrics provides customizable coverings for their creations. Supplied fabric swatches, including black spandex (e.g. for caves, darkness), and white twill can be drawn on with fabric markers and machine washed after use. Fabric is secured to the bars by magnetic 'pebbles.'
The white segments of the bars are constructed of 100% recycled milk jugs (HDPE), and although they have a thin steel core, conventional recycling methods separate the two easily. When the bars are heated to a certain temperature, the triangular securing piece near each end melts, causing the other parts to disassemble themselves into reusable, virgin materials.


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Homeostatic control of oxygen availability allows cells to survive oxygen deprivation. Although the transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator of the hypoxic response, the upstream mechanisms required for its stabilization remain elusive. Here, we show that p75 neurotrophin receptor (p75(NTR)) undergoes hypoxia-induced γ-secretase-dependent cleavage to provide a positive feed-forward mechanism required for oxygen-dependent HIF-1α stabilization. The intracellular domain of p75(NTR) directly interacts with the evolutionarily conserved zinc finger domains of the E3 RING ubiquitin ligase Siah2 (seven in absentia homolog 2), which regulates HIF-1α degradation. p75(NTR) stabilizes Siah2 by decreasing its auto-ubiquitination. Genetic loss of p75(NTR) dramatically decreases Siah2 abundance, HIF-1α stabilization, and induction of HIF-1α target genes in hypoxia. p75(NTR-/-) mice show reduced HIF-1α stabilization, vascular endothelial growth factor (VEGF) expression, and neoangiogenesis after retinal hypoxia. Thus, hypoxia-induced intramembrane proteolysis of p75(NTR) constitutes an apical oxygen-dependent mechanism to control the magnitude of the hypoxic response.
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Start learning with our library of video tutorials taught by experts. Get started
Learn how to use Shake to create photorealistic visual effects for movies, special effects for commercials, and short films.
"My biggest problem is figuring out what I want to watch next. Just when I think I'm all set, I find something ELSE that is fascinating." —John O.
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Watch The Kardashians Rap In Bikinis During Dominican Republic Trip [VIDEO]
The Kardashians have united in a Notorious B.I.G. way. Kylie and Kendall Jenner have just released their latest family video with a cover of the rapper's single, "Hypnotize."
Rumor Has It… Kim Kardashian Forbids Kanye West From Seeing Rihanna [AUDIO]
Taped in the Dominican Republican where the family filmed episodes for their current "Keeping Up With The Kardashians" season, the video showcases the family's amusing and laughable sides as the ladies rap in their leopard bikinis while the guys throw fake money in matching board shorts and tanks.
A pregnant Kourtney Kardashian participates on a giant yacht while Kim Kardashian shows off a variety of sexy swimsuits. Bruce Jenner is seen tapping Kris Jenner's butt before Kylie and Kendall are caught traveling on donkeys. What the what?!
We can't forget about the bromance between Rob Kardashian and Scott Disick that seems alive and well. By the way, is Scott really wearing a purple do-rag on vacation?
New 'KUWTK' Trailer Gives Fans A Glimpse Into Kim & Kanye's Relationship [VIDEO]
It isn't the first time the family has bonded together over a viral video. The Kardashian's created a video to Katy Perry and Kanye West's "ET." Before that, the family danced to the "Moulin Rouge" classic "Lady Marmalade."
Devoted Kardashian fans may be disappointed to find out Khloe Kardashian and husband Lamar Odom are nowhere to be found on this vacation. Regardless, the video is still must see. Watch it below and make sure to stay tuned until the very end. The outtakes feature a surprise windstorm that catches all of the family off guard.


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Capcom had a Metroid Prime Style Mega Man in Development Before it was Canceled
Man, this would have been cool. Capcom greenlit a Mega Man, first person shooter, made by the creators of Metroid Prime in 2010. The game was canceled when Keiji Inafune left the company a few years ago.
The reboot was code named Maverick Hunter, and was being developed by Armature Studio. Armature Studio was founded by the Metroid Prime Creator. The game was going to take a darker tone than the past Mega Man games, while having the structure of the Mega Man X series.
The game was canned six months into development though. Check out some of the footage of the game, other than the character design, which I'm guessing wasn't complete, everything looks solid.
You can actually watch the game running through the link here.
More From Playeressence
Lighting Returns Is Xenoblade Worthy of Diablo 3 PvP Canned Battle System GOTY?Playeressence Original Next Generation News All the Top Gaming News Content & Shows Central, All info here For the day here
3 Responses to Capcom had a Metroid Prime Style Mega Man in Development Before it was Canceled
I'm not exactly sad that this game got canned.
With Metroid, the Prime style game-play works. The mechanics of the game translate well to first person view. The biggest thing that made Metroid Prime a great game for me. Is that it was a first person adventurer, not a first person shooter. I personally don't like this style of game-play for Megaman, and I definitely don't want it turned into a FPS, because knowing Capcom. They wouldn't focus on creating an adventure. Just another shooter that sells for the sake of being a shooter. This actually looks looks like it takes more cues from the Transformers War For/Fall of Cybertron series.
Not to mention I'm a little jaded by the stagnation that is the FPS genre.
Leave a Reply
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From the outside you see a nice building, old design, also lobby is large and beatiful with the glass wall and everything. People on the reception are friendly and very open to your needs. On the way to your room things start to change, you see wooden cover with terrible maintenance and carpets with bad appearance. Once you are inside... More
Brazil >
State of Santa Catarina >
Number of rooms: 37
- Also Known As:
- Viena Park Hotel Blumenau, Brazil


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Final / OT
Series starts 12/1
Game 1: Saturday, December 1st | ||
Grizzlies | 95 | Final OT |
Spurs | 99 | |
Recap »Boxscore » |
Game 2: Friday, January 11th | ||
Spurs | 98 | Final OT |
Grizzlies | 101 | |
Recap »Boxscore » |
Game 3: Wednesday, January 16th | ||
Grizzlies | 82 | Final |
Spurs | 103 | |
Recap »Boxscore » |
Game 4: Monday, April 1st | ||
Spurs | 90 | Final |
Grizzlies | 92 | |
Recap »Boxscore » |
8:00 PM ET, January 11, 2013
FedExForum, Memphis, TN
MEMPHIS, Tenn. -- Memphis coach Lionel Hollins warned his Grizzlies they could feel sorry for themselves after Tony Parker hit a 27-footer at the buzzer to force overtime or they could go back out and win the game.
The Grizzlies chose the second option.
Rudy Gay hit a pullup jumper from 14 feet with 27.8 seconds left, and the Grizzlies held off the San Antonio Spurs 101-98 in overtime Friday night for their fourth straight victory and their first over their Southwest Division rival since the 2011 playoffs.
"It was a good test of our mental toughness and our togetherness because we did stick together," Hollins said. "We kept operating efficiently offensively, and nobody really tried to go off on their own, and we got the win."
San Antonio had won five straight in the series since the Grizzlies upset the then-No. 1 seed in the opening round in 2011 in six games. The Spurs also had a 2 1/2-game divisional lead on Memphis going into this game despite Memphis having played five fewer games, and the teams played at postseason intensity despite the calendar.
"It's always going to be a playoff-type feel when you play those guys, no matter whether it's the playoffs or a regular-season game," Grizzlies guard Tony Allen said. "It's all a test for the postseason. We've got a lot of weapons. As long as we play together and play for each other, good things are going to happen. We've just got to grind it out for 48 minutes."
The Grizzlies needed five more minutes after Parker's 27-footer beat the buzzer and tied it at 95. He also opened overtime with a 3 that turned out to be the Spurs' only bucket as San Antonio went 1-of-10 from the floor. Manu Ginobili missed a long 3 just before the buzzer.
"That was an incredible shot by Tony to give us a chance to stay in the game and get five more minutes to figure it out," Spurs forward Tim Duncan said. "We started out pretty well and got ourselves a lead, but they just kept coming. They just made more plays than we did. They just outplayed us."
Darrell Arthur's dunk with 8.9 seconds left gave the Grizzlies the final margin and forced the Spurs to take the desperation shot at the end of the game. Ginobili's shot hit the backboard and then the rim.
Gay led Memphis with 23 points, and Mike Conley had 21 points and five assists, hitting all 10 of his free throws. Zach Randolph had 18 points and 10 rebounds for his NBA-leading 24th double-double of the season. Arthur had 14, while Marc Gasol and Allen each added 10. Allen also had three steals on his 31st birthday.
Conley said he thought Ginobili's last shot would go in after watching Parker's 3 tie it up in regulation.
"I thought the team did a great job of not holding their head after a phenomenal shot and two missed free throws," Conley said. "We had the game in the bag, and for them to come back and make it a game and for us to still play hard and not get rattled, showed a lot of self and mental toughness."
Parker finished with 30 points and five assists for the Spurs. Ginobili had 14, and Duncan and Tiago Splitter each had 13. Duncan also grabbed 15 rebounds but was 5-of-14 shooting.
"It's just like a hitter who doesn't hit for a while," Spurs coach Gregg Popovich said. "What are you going to do? You just keep shooting. He keeps playing hard whether a shot goes in or out."
The Spurs went in tied with the Clippers with a league-best 28 wins, but they've struggled lately away from San Antonio, losing seven of their past nine road games.
Memphis had just gotten back in town from winning three straight on the road, and the Grizzlies saw a chance to chase down the Spurs for the top of the Southwest Division.
San Antonio also needed overtime to beat Memphis 99-95 on Dec. 1 in the teams' first meeting this season, and this was another doozy with 14 lead changes and 11 ties.
The Spurs thought they had a 100-97 lead when officials ruled goaltending on Gay on a bucket by Ginobili with 44.5 seconds left. But they overturned the ruling after reviewing the play, and called jump ball between Duncan and Arthur. The Grizzlies forward won the tip, knocking it out to Conley. Gay hit the jumper on the possession to put Memphis ahead to stay.
Popovich said he thought it was a good block before the review. Hollins wasn't happy his Grizzlies had to win the tip after getting a good block.
The Grizzlies led 95-92 when Randolph hit two free throws with 3.5 seconds left. That was just enough time, as Parker took the ball and dribbled up the left side before tossing up a 27-footer that beat the buzzer to force overtime.
"Pop told me to push it and if nobody came to help then to take it," Parker said. "We tried to send Manu and Danny (Green) ahead, and nobody came to me so I just took it."
Memphis outscored the Spurs 29-18 in the second quarter and led 60-48 before the Grizzlies started struggling offensively yet again in the third quarter. The Spurs had a 28-17 edge in the third to eat away at the Grizzlies' 12-point lead. But Memphis outscored San Antonio 27-24 in the fourth and 6-3 in overtime.
Game notes
The Spurs had been 19-2 when leading after the fourth quarter. The Grizzlies outscored the Spurs 50-40 in the paint and now have 138 straight games in which they have forced at least 10 turnovers. They forced 18 on Friday night, leading to 26 points.
Next 5 Games
San Antonio | Memphis |
01/13 MIN 7:00pm 01/16 MEM 8:30pm 01/18 GS 8:30pm 01/19 @ATL 7:00pm 01/21 @PHI 7:00pm |
01/12 @DAL 9:00pm 01/14 LAC 8:00pm 01/16 @SA 8:30pm 01/18 SAC 8:00pm 01/19 @CHI 8:00pm |
Complete Schedule: San Antonio | Memphis |


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South Florida designer /skater Benny Gold is making room for his new fall collection by giving out 30% off in-store and online.
All Tees are going for $21 bucks (whaaaatt!)
Support Our Florida Talent!
"Supplies are extremely limited and once it's gone it's gone for good. No reprints ever! " -Benny Gold
Tee Addicts Picks:
Hang Loose:
A humorous play on the classic surf/ skate phrase "Hang Loose" A gold tooth throwing a shaka and hanging loose. Skate safe and watch out for slams on the face that loosen teeth.
Gold Trust:
Custom "In Gold We Trust" lettering printed with metallic gold highlights. I have been messing with this style of lettering for a while now and it gets better every time.
The Hundreds x Benny Gold :
Our Glider Plane artist series continues with The Hundreds. Bobby and I both grew up into the hardcore music scene. It's only appropriate for our collab to allude to a moshpit with flying fists, classic finger points and all the amazingness that goes along with it
Union Label:
Inspired by vintage union labels, the Benny Gold brand prides itself on handmade quality and being independently owned. This shirt coordinates with our Gold Standard Denim and Union Label Snap Back.
Until next time,
- Andres
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Home for the weekend for Christmas at the David and Lenora Salwei home were Kim, Al, Clarisa, Abby and Kristin Albrecht from Pembina; Mary, Bob, Alicia and Amanda Miranowski from Breckenridge, Minn.; and Steve, Deb, Ashley, Samantha, Morgan and Michael Salwei from Bismarck.
Rachel Nolz arrived at the home of her parents, Eugene and Brenda Nolz, on Saturday morning. Saturday afternoon Nicole, Jazlyn, Mason, and Brandi Weigel arrived at the Nolz home. They all went to Wishek where they visited with Wilbert and LaVerne Vossler. On Sunday Chris Weigel joined the group for Christmas celebration consisting of dinner and opening of presents. On Tuesday evening Eugene, Andy, Brenda and Rachel Nolz went to visit at the home of Chris and Nicole Weigel. Rachel returned to Minneapolis, Minn., on Wednesday morning.
Saturday evening Tom, Joyce and Emily Scherr went along to Bernie's Beefstro with Brenda and Rachel Nolz and Nikki, Jazlyn, Mason and Brandi Weigel. On Christmas Eve Kristen Scherr stopped in at the Scherr farm on her way to Gettysburg, S.D. While here she visited with Frank, Vicki, Rebecca and Hannah Meier. Later the Meiers and Tom, Joyce and Emily attended
Christmas Eve mass at St. Andrew's Catholic Church. Christmas Day Tom, Joyce and Emily went to the Frank and Vicki Meier home to enjoy a fantastic turkey dinner. On Wednesday, Tom and Emily went to Jamestown to pick up Kaydence, Konnor and Makita who will be spending the week at the farm.
Home for Christmas Eve at the Jim Feists were Dennis and Wendy Feist and family; Mike Feist, Brelyn and Tayden all from Herreid, S.D.; Veronica and Wayne Peterson and family from Wilton; Bethany Feist and Mike Heilman from Bismarck. Amanda and Jaden Roehrich were unable to come as they just welcomed Caleb Jaden to their family on the 20th of December. This is James and Marie's 17th grandchild. Big Sister Taylor says he can stay. Melanie and Perry Ryckman family were also unable to attend. Christmas Day supper guests were Dennis and Wendy and family, Mike Feist, and Bethany and Mike Heilman. They all enjoyed cooking and eating and visting. Also some ice fishing was going on. This past SundayAmanda and Jaden Roehrich and family came for the weekend. Everyone got to spoil Caleb. Dennis and Wendy Feist and family and Bethany Feist were also home.
Christmas was celebrated this past weekend at the home of Bill and Millie Wald. Arriving Thursday afternoon was Neceda Nohrenberg from Minneapolis, Lee, Misti, Reagan, Avery and William Wald from Kearney, Mo., came in the evening. Arriving on Friday were Twila and Bob Nohrenberg from Horace, Betty, Kevin, Jared and Marcus Thune, Jim, Darcy, Maria and Isaac Hoff,Alvin, Bonnie, Mitchel, Conner, Emma and Dominic Wald from Bismarck. Sheila Johnson, Jade, Julisa and Joclyn from West Fargo and Sheila's friend, Scott, from Grand Forks. All returned to their homes on Sunday except Lee and family who left Monday morning.
The Scherrs celebrated their Christmas this past weekend. Alisha and Willie came home from Fargo on Friday. Kristen, Travor, Kaydence and Konnor Reis and Emily were already there. Gifts were opened and the highlight of this years gift opening was the Little Giant Xtreme ladder that Tom received. His reaction was priceless!! Saturday the flu hit a few of us. Sunday we celebrated Kristen's 25th birthday with cake and ice cream. Afterwards everyone went back to Fargo and Bismarck.
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- Final0OTT
0 - Final SOSO1NYI
3 - Final OTOT2DET
2 - Final3CGY
3 - Final4LA
5 - Final5NSH
Colorado leads 3-1
Game 1: Friday, October 4th | ||
Predators | 1 | Final |
Avalanche | 3 | |
Preview »Recap »Boxscore » |
Game 2: Wednesday, November 6th | ||
Predators | 6 | Final |
Avalanche | 4 | |
Preview »Recap »Boxscore » |
Game 3: Saturday, January 18th | ||
Avalanche | 5 | Final |
Predators | 4 | |
Preview »Recap »Boxscore » |
Game 4: Tuesday, March 25th | ||
Avalanche | 5 | Final SO |
Predators | 4 | |
Preview »Recap »Boxscore » |
9:00 PM ET, October 4, 2013
Pepsi Center, Denver, Colorado
Points | Goals | Assists | |
NSH | S Weber 56 | C Smith 24 | S Weber 33 |
COL | M Duchene 70 | R O'Reilly 28 | M Duchene 47 |
P. Parenteau (Avalanche - RW): Goals: 2, Assists: 0
P. Rinne (Predators - G): Saves: 33, Save Pct.: .943
S. Varlamov (Avalanche - G): Saves: 26, Save Pct.: .963
DENVER -- The Colorado Avalanche are showing they won't be pushed around this season.
Semyon Varlamov stopped 26 shots, P.A. Parenteau scored two goals and the Colorado Avalanche beat the Nashville Predators 3-1 on Friday night.
Patrick Bordeleau had a goal and rookie Nathan MacKinnon had an assist for the Avalanche, who have won their first two games under new coach Patrick Roy with another physical showing.
Pekka Rinne had 33 saves and Paul Gaustad scored for the Predators, who lost for the second time in as many nights.
The game featured two of the top four picks in last June's draft. MacKinnon was taken first overall and Seth Jones, a Denver native, was picked fourth by the Predators. The friends were on the ice together throughout the game but didn't chat much.
"It felt a little different from the Memorial Cup," Jones said. "I didn't really talk to him before the game. Lined up with him a couple of times and small talk."
Said MacKinnon: "I talked to him a little bit. He's my buddy."
For the second straight game, the Avalanche created some controversy. Forward Steve Downie drew the ire of the opponent a day after Roy was fined $10,000 by the league for his actions in the opener. Downie left his feet to deliver a hit on Roman Josi and knocked the Nashville defenseman out of the game with an upper-body injury.
Shea Weber and Gabriel Bourque went after Downie before the officials broke it up.
"We're trying to get all of that out of the game, launching yourself, especially the head shots," Predators coach Barry Trotz said. "If you watch the film it's pretty self-explanatory and the league will handle it correctly. There will be something to come out of it I think."
It was a tough loss for the Predators, who lost a skilled defenseman when they're struggling defensively.
"We need some of our skill guys to step up. No production from some of our skill guys," Trotz said. "We've got some work to do. There were lots of positives, but the negative is we didn't' win the game."
Colorado saw Downie's hit differently.
"That was a great hit. I thought it was a fair check," Roy said. "What I like about Steve is he is a great leader and he plays hard. He doesn't go wild. He stays composed, he stays focused and he doesn't get rattled."
The Avalanche scored first for the second straight game. Jamie McGinn, who had two goals in Wednesday's win, gloved the puck in the slot and fired a shot on Rinne, who made the initial save.
Parenteau jumped on the rebound and knocked it in to give Colorado a 1-0 lead with 1:10 left in the first period.
"It was a great play by Jamie McGinn, keeping it in there and shooting at the net," Parenteau said. "It was a strong effort and I was there to get the rebound."
Colorado made it 2-0 at 7:54 of the second with a goal from the fourth line. Bordeleau, the team's enforcer, tipped in a shot from the point by Nate Guenin for his third career goal.
"It's just one of those plays where it just goes in," Rinne said. "I think it hit the post and went in. It was a good tip for him. Our guy, Gaustad, was trying to block the shot and it went through his legs."
Nashville cut the lead in half with a goal at the end of a power play. Gaustad spun and used Avalanche defenseman Jan Hejda as a screen to beat Varlamov with 5:50 left in the second.
The Predators couldn't get the equalizer, but they got back at Downie when defenseman Victor Bartley checked him into the Nashville goal at the end of a play midway through the third.
"They came up and were supporting a teammate," Trotz said.
Parenteau put the game away with an empty-net goal with 1:12 left.
Game notes
The Predators said Josi will be evaluated this weekend. ... Avalanche C Gabriel Landeskog (leg) was scratched. He is day to day. ... Rinne is 11-4-1 against Colorado in his career. ... Nashville C Filip Forsberg was scratched with a lower body injury.
Photo Wire
DENVER, CO - OCTOBER 4: General view of the Pepsi Center before the Colorado Avalanche skate against the Nashville...
(Photo by Michael Martin/NHLI via Getty Images)Game Information
Arena: Pepsi Center Location: Denver, Colorado |
Referees: Ian Walsh, Ian Walsh Linesmen: Lonnie Cameron, Scott Driscoll |
Attendance: 14,494 (80.5% full) |
Team Stat Comparison
Nashville | Colorado | ||
1 | Goals | 3 | |
0 | Power Play Goals | 0 | |
3 | Power Play Opportunities | 5 | |
0 | Shorthanded Goals | 0 | |
8 | Penalties | 5 | |
16 | Penalty Minutes | 10 | |
27 | Shots on Goal | 36 | |
14 | Hits | 19 | |
31 | Faceoffs Won | 23 |
Scoring Summary
1st Period | NSH | COL | ||
18:50 | P.A. Parenteau (1)
Assists: Jamie McGinn, Nathan MacKinnon |
0 | 1 | |
2nd Period | NSH | COL | ||
7:54 | Patrick Bordeleau (1)
Assists: Nate Guenin, Marc-Andre Cliche |
0 | 2 | |
14:10 | Paul Gaustad (1)
Assists: Mike Fisher, Craig Smith |
1 | 2 | |
3rd Period | NSH | COL | ||
18:48 | P.A. Parenteau (2)
Assists: Paul Stastny, John Mitchell |
1 | 3 |
© 2015 ESPN Internet Ventures. Terms of Use, Privacy Policy, Your California Privacy Rights, Children's Online Privacy Policy and Interest-Based Ads are applicable to you. All rights reserved.


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This Week's Performers
< Back to all posts-
It's going to be a mid-February miracle in the crypt this weekend as we host SIX AMAZING SINGER-SONGWRITER SOLO PERFORMERS! Do yourself a favor and check out their music in the links below! If you've got a itch for some toe-tappin' good tunes, then come to the crypt on Friday (2/22) and Saturday (2/23) for a folkin' good time! Postcrypt is FREE (no cover!), ALL AGES, and OPEN TO THE PUBLIC!
Friday 2/22:
"This is mellow music that, in the rawest and most honest of manners, captures and explores the emotional terrain and fallout of a broken-hearted, aching soul." - Wave Maker Magazine
"Jo Schornikow has an incredibly warm voice that carries such an emotional punch…combined with poignant lyrics, beautiful minor chords and lo-fi tape hiss she conjures up a very moving and intimate exposure of the bedroom heart." - Folk Radio UK
With carefully crafted lyrics, arching melodies and ragged, soulful vocals, Cooper Formant makes beautiful music that we can't stop listening to!
Saturday 2/23:
"It is rare to find an artist who can stand up so well without musical adornments or lavish processing. Lorraine Leckie's Martini Eyes is short, poignant, and worth many listens." - Origivation Magazine
"Cellist Calum Ingram kicked things off, this time with a trio, playing his raw, high-energy blend of blues and funk, this time beginning with an intriguing jazz waltz groove" - New York Music Daily
"Wow. Joe Yoga just blew me away with a song that literally deserves to be in some kind of anthology of great American songs. Holy crap." - Astoria Music and Arts


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PMI Accessory Cord
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Europe confidence lifts global equities
PUBLISHED: 20 Feb 2013 04:03:20 | UPDATED: 20 Feb 2013 12:08:37PRINT EDITION: 20 Feb 2013Before the Bell | Shares in Europe were lifted by positive German data, while US markets gained on talk Office Depot would merge with a smaller rival ■ Dow up 0.4pc ■ SPI futures up 16 pts ■ $A at $US1.035.
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Kick them nasty thoughts. |
But platonically, y'know? We didn't love it love it.
As Sunday's season finale draws near, however, it seems like Dexter's writers have other plans. As if season six didn't already have its share of jaw-droppers with all the Doomsday Killer madness, we now have a potential sibling-on-sibling romance to simmer on the brainpan.
In Sunday's episode, Debra Morgan's therapist suggests that Deb might have romantic feelings for her adoptive brother Dexter. Whether or not the accusation is correct, or if perhaps the therapist wrongfully manipulated Deb, the seed has irrevocably been planted. Deb's inner crisis was crystallized with an awkward dream sequence in which brother and sister kiss over Chinese takeout. Not exactly romance.
In the very first episode of the the series, Dexter explained, "If I could have feelings for anyone, I'd have them for Deb." Six seasons later, this comment is starting to seem like a crooked statement of foreshadowing.
On the eve of the season finale, what do you think of the apparently "sudden" sexual tension between Deb and Dexter?
--Grace Stainback
Follow Cultist on Facebook and Twitter @CultistMiami.
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The immune system is an integral part of human protection against disease, but the normally protective immune mechanisms can sometimes cause detrimental reactions in the host. Such reactions are known as hypersensitivity reactions, and the study of these is termed immunopathology. The traditional classification for hypersensitivity reactions is that of Gell and Coombs and is currently the most commonly known classification system.[1] It divides the hypersensitivity reactions into the following 4 types:
Some authors believe this classification system may be too general and favor a more recent classification system proposed by Sell et al.[3] This system divides immunopathologic responses into the following 7 categories:
This system accounts for the fact that multiple components of the immune system can be involved in various types of hypersensitivity reactions. For example, T cells play an important role in the pathophysiology of allergic reactions (see Pathophysiology). In addition, the term immediate hypersensitivity is somewhat of a misnomer because it does not account for the late-phase reaction or for the chronic allergic inflammation that often occurs with these types of reactions.
Allergic reactions manifest clinically as anaphylaxis, allergic asthma, urticaria, angioedema, allergic rhinitis, some types of drug reactions, and atopic dermatitis. These reactions tend to be mediated by IgE, which differentiates them from pseudoallergic (formerly called anaphylactoid) reactions that involve IgE-independent mast cell and basophil degranulation. Such reactions can be caused by iodinated radiocontrast dye, opiates, or vancomycin and appear similar clinically by resulting in urticaria or anaphylaxis.[4, 5]
Patients prone to IgE-mediated allergic reactions are said to be atopic. Atopy is the genetic predisposition to make IgE antibodies in response to allergen exposure.[6]
The focus of this article is allergic reactions in general. Although some of the clinical manifestations listed previously are briefly mentioned, refer to the articles on these topics for more detail. For example, see Allergic and Environmental Asthma; Anaphylaxis; Food Allergies; Rhinitis, Allergic; and Urticaria.
Immediate hypersensitivity reactions are mediated by IgE, but T and B cells play important roles in the development of these antibodies. T helper (TH) cells, which are CD4+, have been divided into 2 broad classes based on the cytokines they produce: TH1 and TH2.[7, 8] Regulatory T cells (Tregs) are CD4+CD25+ and may also play a role.[9]
TH1 cells produce interferon gamma, interleukin (IL)–2, and tumor necrosis factor-beta and promote a cell-mediated immune response (eg, delayed hypersensitivity reaction). TH2 cells, on the other hand, produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Therefore, TH2 cells play an important role in the development of immediate hypersensitivity reactions, and patients who are atopic are thought to have a higher TH2-to-TH1 cell ratio. Interestingly, the cytokines produced by TH1 cells (specifically interferon gamma) seem to diminish the production of TH2 cells.[10, 7, 8] Current evidence suggests that Tregs may also actively inhibit TH2 responses to allergens.[9]
The allergic reaction first requires sensitization to a specific allergen and occurs in genetically predisposed individuals. The allergen is either inhaled or ingested and is then processed by the dendritic cell, an antigen-presenting cell.[11] The antigen-presenting cells then migrate to lymph nodes, where they prime naive TH cells (TH0 cells) that bear receptors for the specific antigen.
TH0 cells are undifferentiated CD4 cells that release both TH1 and TH2 cytokines and can develop into either cell type. In the case of allergen sensitization, the TH0 cells are thought to be exposed to IL-4 (from as yet unidentified sources, but including germinal-center B cells) and possibly to histamine-primed dendritic cells, both of which cause them to develop into TH2 cells. These primed TH2 cells then release more IL-4 and IL-13. IL-4 and IL-13 then act on B cells to promote production of antigen-specific IgE antibodies.
For this to occur, B cells must also bind to the allergen via allergen-specific receptors. They then internalize and process the antigen and present peptides from it, bound to the major histocompatibility class II molecules found on B-cell surfaces, to the antigen receptors on TH2 cells. The B cell must also bind to the TH2 cell and does so by binding the CD40 expressed on its surface to the CD40 ligand on the surface of the TH2 cell. IL-4 and IL-13 released by the TH2 cells can then act on the B cell to promote class switching from immunoglobulin M production to antigen-specific IgE production (see image below).
View Image | Immediate hypersensitivity reactions. Sensitization phase of an immunoglobulin E–mediated allergic reaction. |
The antigen-specific IgE antibodies can then bind to high-affinity receptors located on the surfaces of mast cells and basophils. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release and formation of chemical mediators from these cells. These mediators include preformed mediators, newly synthesized mediators, and cytokines. The major mediators and their functions are described as follows:[7, 8]
The actions of the above mediators can cause variable clinical responses depending on which organ systems are affected, as follows:
Allergic reactions can occur as immediate reactions, late-phase reactions, or chronic allergic inflammation. Immediate or acute-phase reactions occur within seconds to minutes after allergen exposure. Some of the mediators released by mast cells and basophils cause eosinophil and neutrophil chemotaxis. Attracted eosinophils and resident lymphocytes are activated by mast cell mediators.
These and other cells (eg, monocytes, T cells) are believed to cause the late-phase reactions that can occur hours after antigen exposure and after the signs or symptoms of the acute-phase reaction have resolved. The signs and symptoms of the late-phase reaction can include redness and swelling of the skin, nasal discharge, airway narrowing, sneezing, coughing, and wheezing. These effects can last a few hours and usually resolve within 24-48 hours.
Finally, continuous or repeated exposure to an allergen (eg, a cat-owning patient who is allergic to cats) can result in chronic allergic inflammation. Tissue from sites of chronic allergic inflammation contains eosinophils and T cells (particularly TH2 cells). Eosinophils can release many mediators (eg, major basic protein), which can cause tissue damage and thus increase inflammation. This can result in structural and functional changes to the affected tissue. Furthermore, a repeated allergen challenge can result in increased levels of antigen-specific IgE, which ultimately can cause further release of IL-4 and IL-13, thus increasing the propensity for TH2 cell/IgE–mediated responses.[8]
History findings vary depending on which organ systems are affected.
Physical examination findings vary with the organ system involved.
Atopy is defined as the genetic predisposition to form IgE antibodies in response to exposure to allergens. Therefore, a genetic predisposition exists for the development of atopic diseases. Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms.[31] Impaired function of Treg cells may also contribute to the development of atopic diseases.[32]
Environmental issues also play an important role, although the role that exposure at an early age to certain antigens might play in either the progression to or the protection from the development of an allergic response remains unclear. Some studies have shown that children in day care and those with older siblings may be less likely to develop allergic disease. The environment certainly can help determine the allergens to which the patient will be exposed. For example, children in inner cities are more likely to be sensitized to cockroaches than are children in suburban or rural areas. Similarly, dust mites, a potent allergen, are primarily found in humid climates, and those who have never been exposed to such a climate are less likely to be allergic to mites.
Some laboratory tests may be helpful in determining whether a reaction is truly allergic in nature.
Obtaining a serum tryptase level soon after the onset of symptoms can be helpful in differentiating anaphylaxis from other forms of shock and from other symptom complexes that may be confused with anaphylaxis. The tryptase level can be elevated, which is indicative of mast cell degranulation. False-negative results can occur. Ideally, the tryptase level should be drawn within 4 hours after the event, but it can be drawn up to 15 hours later. Measurement of urinary histamine may also be useful.
An elevated eosinophil count may be observed in patients with atopic disease.
IgE levels may be elevated in patients who are atopic, but the level does not necessarily correlate with clinical symptoms.
The radioallergosorbent test (RAST) and other in vitro IgE assays measure antigen-specific IgE and can be useful in identifying which allergens are causing symptoms for the patient. More sensitive tests have been available in recent years and have a greater positive predictive value for foods. These tests can sometimes detect clinically irrelevant allergens, however, creating false-positive results to some foods. Molecular diagnostic tests are now available that can detect allergenicity to specific food protein molecules known to trigger IgE-mediated reactions.[33]
Treatment may vary depending on the type of allergic reaction. Some general observations are made below, but refer to articles on the specific topics for more details about treatment (eg, Anaphylaxis; Rhinitis, Allergic; Allergic and Environmental Asthma; Urticaria).
Medical therapy varies somewhat depending on which type of allergic reaction is being treated. Some of the drugs and their categories are listed here, but refer to the articles on the specific allergic reaction for more detail.
Clinical Context: Should be administered immediately for anaphylaxis/anaphylactic shock. Multiple preparations allow for delivery SC, IM, IV, or ET. Doses can be repeated q5min prn to maintain blood pressure (and as heart rate allows).
First-line choice to reverse effects of systemic vasodilation and increased vasopermeability observed with anaphylaxis. Although not the first choice for bronchoconstriction, epinephrine can also relieve some symptoms of bronchospasm and rhinitis. In the past, protocols called for subcutaneous or intravenous administration of epinephrine. However, studies have shown that intramuscular epinephrine leads to higher plasma levels than subcutaneous delivery. Intramuscular administration is now preferred over subcutaneous administration.[43, 44]
Predosed autoinjectable epinephrine is available in at least 2 forms, which include EpiPen and Twinject. Two doses of each are available (0.3 mg for EpiPen or Twinject 0.3 and 0.15 mg for EpiPen Jr. or Twinject 0.15). One Twinject pen actually has 2 doses of epinephrine available, which can be administered separately, and also has directions printed on a wraparound label on the pen that can be referred to at the time of use. The EpiPen has also been redesigned for easier use and has instructions on the pen. EpiPen Two-packs contain 2 pens and, therefore, 2 doses. Twinject Two-packs contain 2 pens for a total of 4 doses.
Clinical Context: Sympathomimetic that stimulates beta-2 receptors, leading to bronchodilation. Used for bronchospasm refractory to epinephrine with anaphylaxis. First-line choice for acute bronchospasm associated with asthma.
Clinical Context: Fluticasone, budesonide, and mometasone are steroids. They inhibit bronchoconstriction mechanisms, may decrease number and activity of inflammatory cells, in turn decreasing airway hyper-responsiveness. Also may have vasoconstrictive activity.
Salmeterol and formoterol relax the smooth muscles of the bronchioles in conditions associated with bronchitis, emphysema, asthma, or bronchiectasis, and can relieve bronchospasm. Effect may also facilitate expectoration. Advair is available both as an HFA-propelled MDI and as a dry powder inhaler. Symbicort and Dulera are only available as an MDI.
Adverse effects are more likely to occur when administered at high or more frequent doses than recommended.
Inhaled bronchodilators are beta-agonists that come in short- and long-acting forms. Short-acting bronchodilators are used to treat acute bronchospasm. Can also be used prophylactically. For example, a patient with a history of asthma exacerbation in the presence of cats can use a short-acting bronchodilator before exposure to cats. Long-acting bronchodilators (eg, salmeterol) can be used twice daily and to help maintain bronchodilation over 12 h. In asthma patients, they should only be used in conjunction with inhaled glucocorticoids.
Pirbuterol and formoterol have both short- and long-acting activity. Onset of action is approximately 15 min, but effects last up to 12 h. Of note, when long-acting beta agonists are used alone, concern exists of increased mortality in asthma patients. These medications should be combined with an inhaled corticosteroid and should be reserved for patients with more frequent or moderate to severe symptoms or lung function. Finally, levalbuterol is the R-enantiomer of albuterol and is available in nebulizer and metered dose inhaler (MDI) forms. Advantage of levalbuterol is that it is less likely to cause paradoxical bronchospasm than racemic albuterol.
Previously, MDIs were made using chlorofluorocarbons (CFCs) as the propellant. However, the use of CFCs has been phased out because of environmental concerns. For this reason, companies are now making MDIs with hydrofluoroalkane-134a (HFA), which is not damaging to the ozone layer. CFC inhalers are no longer available in the United States.
Clinical Context: Believed to ameliorate delayed effects of anaphylactic reactions and may limit biphasic anaphylaxis. Doses below are general guidelines for usage; dosing is highly individualized.
Immunosuppressing agents and, thus, can decrease inflammation. Have particular efficacy in skin eruptions and bronchospasm. Role in anaphylactic shock is limited, although believed to help prevent delayed type of anaphylaxis.
Several different formulations are available; only one is listed. Others include methylprednisolone, dexamethasone, prednisolone (often used in children), and hydrocortisone. Depending on type of corticosteroid, oral, intravenous, and topical forms may be available. In more severe cases of anaphylaxis and asthma, intravenous forms of corticosteroids can be used initially. These can later be switched to oral forms as doses are tapered.
Inhaled corticosteroids are another form of corticosteroids and are key in controlling inflammation of bronchial airways and nasal mucosa. Similarly, topical corticosteroids are useful in treating atopic dermatitis.
Clinical Context: Most widely available antihistamine (available OTC). Sedating antihistamines may be necessary to control more severe allergic reactions because they are very potent. Dosing interval of diphenhydramine is 4-6 h. Nonsedating antihistamines are all now available in a 24-h formulation but can only be administered PO.
Clinical Context: An effective antihistamine delivered via the intranasal route. Mechanism is similar to oral antihistamines. Systemic absorption occurs and may cause sedation, headache, and nasal burning.
Forms complex with histamine for H1-receptor sites in blood vessels, GI tract, and respiratory tract.
Use prn or qd. Use alone or in combination with other medications. Unlike oral antihistamines, has some effect on nasal congestion. Helpful for vasomotor rhinitis. Some patients experience a bitter taste. Systemic absorption may occur, resulting in sedation (reported in approximately 11% of patients).
Clinical Context: Selectively inhibits histamine H1 receptor sites in blood vessels, GI tract, and respiratory tract, which in turn inhibits physiologic effects that histamine normally induces at H1 receptor sites. Once-daily dosing is convenient. Bedtime dosing may be useful if sedation is a problem.
Type 1 histamine-receptor blockers act to block action of histamine on H1 receptor after its release from mast cells and basophils. Most effective when used prophylactically. Sedating first-generation and nonsedating second-generation H1 antihistamines are available. Typically, sedating antihistamines have more adverse anticholinergic effects. Sedating antihistamines include diphenhydramine, hydroxyzine, cyproheptadine, chlorpheniramine, and brompheniramine. Nonsedating antihistamines include cetirizine (cause drowsiness in 15% people), fexofenadine, loratadine, and desloratadine. Desloratadine and fexofenadine may also help decrease nasal congestion. Liquid forms are more rapidly absorbed orally and should be used for immediate treatment of an allergic reaction if intravenous access is not available.
Clinical Context: Multiple formulations are available. Cimetidine was first to be widely used but tends to have more drug interactions than other H2-receptor blockers. If no response to H1-receptor antagonist alone, coadministration with an H2-receptor antagonist can help relieve symptoms of itching and flushing in anaphylaxis, pruritus, and urticaria. Cimetidine plus an H1 blocker blocks cardiovascular effects of histamine.
Can be administered in addition to H1-receptor blockers for additional control of urticaria and angioedema. Examples include ranitidine, famotidine, and cimetidine. Cimetidine has been studied more extensively for this indication than other members of this class.
Clinical Context: Leukotriene inhibitors can be a helpful addition to asthma and allergic rhinitis not well controlled with H1-receptor blockers and inhaled corticosteroids.
Leukotrienes are synthesized by degranulated mast cells and basophils and likely contribute significantly to symptoms of allergic reactions. Three leukotriene inhibitors are now available in the United States. Montelukast and zafirlukast act as leukotriene D4-receptor blockers, whereas zileuton acts to inhibit production of leukotrienes B4, C4, D4, and E4. Disadvantages of the latter medication are its qid dosing and the need to monitor liver enzymes. However, a sustained release formulation is now available, permitting q12 h dosing; zileuton's ability to inhibit synthesis of leukotrienes C4 and B4 as well as D4 may lead to increased use of this leukotriene modulator for certain indications.
Clinical Context: Reduces itching and inflammation by suppressing release of cytokines from T cells. Can be used in patients as young as 2 y. More expensive than topical corticosteroids.
Tacrolimus is a calcineurin inhibitor initially used in oral form as an immunosuppressant for transplantation patients. It has since been developed in topical form (Protopic) and can be used to treat atopic dermatitis that does not respond well to topical corticosteroids. A similar topical agent, pimecrolimus (Elidel), became available in the past few years and is indicated for mild atopic dermatitis. Systemic calcineurin inhibitors have been shown to cause immunosuppression and certain malignancies such as lymphoma. In January 2006, the FDA issued a black box warning for topical tacrolimus and pimecrolimus for these reasons.[41] To date, studies have not shown significant systemic absorption, systemic immunosuppression, or increased risk of malignancy with the topical formulations. Trials are currently underway to assess possible benefit of inhaled tacrolimus for asthma.
Clinical Context: Binds to IgE and thereby prevents IgE from binding to mast cells and basophils.
Omalizumab (Xolair) is a monoclonal anti-IgE antibody indicated for refractory asthma. Has been shown to greatly improve severity of asthma in patients and can be used to help patients dependent on oral steroids to be weaned from steroids. Omalizumab has also been shown to decrease allergic response to peanuts in patients with severe peanut allergy.[45] This could be helpful in preventing anaphylaxis from accidental peanut exposure in patients who normally would not tolerate even the slightest exposure to peanut allergen, but it only has FDA approval for asthma at this time. Patients should undergo a full allergy evaluation prior to starting omalizumab, if needed, because it interferes with prick skin test and RAST results.


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All eyes were on Irina Shayk as she hit the catwalk for the Liverpool Fashion Fest Spring/Summer 2015 event at Televisa San Angel on Thursday (Feb. 26).
The Russian model walked the runway in a number of show-stopping ensembles. She looked long and lean in a white, strapless peplum top and matching, floor-length skirt. Irina also flaunted her beach body in a colorful high-waisted bikini and wedges.
When Cinderella first met Prince Charming, she was not wearing those glass slippers.
Braving the Boston snow, Jennifer Lawrence stepped out to take her cute pooch, Pippi, for a brisk winter walk.
The 24-year-old actress bundled up in a pair of foral-printed pants, a black parka and fur-lined snow boots. Without a stitch of makeup on, she displayed her flawless complexion and sported a pair of hipster glasses.
Blonde beauty Kate Bosworth and the hunky Joe Manganiello stepped out for the Coca-Cola Bottle: An American Icon at 100 Exhibition on Thursday (Feb. 26) to celebrate 100 years of the iconic drink.
The pair made their way to the High Museum of Art in Atlanta, Georgia for the exhibit's opening night. There, they reminisced about their childhood memories of the classic soda pop.
Braving the winter weather, Olivia Wilde showed off her bare legs and baby blues as she left the Z100 studios in New York City on Thursday (Feb. 26).
The blue-eyed recently gushed to US Weekly about her 10-month-old son Otis with Jason Sudeikis. "He's about to walk. He's teetering and I just don't want him to do it while I'm at work," she told the mag. "He's so smart and just plays his piano all day long. He's really musical so we're trying to encourage that."
Who needs teams?! Margot Robbie stopped by the "Tonight Show" to for a one-on-one battle of flip cup with Jimmy Fallon.
Well, this is awkward. Kim Kardashian and Rita Ora stepped out for the Mert & Marcus House of Love party, which was thrown to celebrate Madonna's incredible career, wearing VERY similar styles.
On the April 2015 cover of Glamour UK, Shailene Woodley is a denim darling in a white top and jeans. However, inside the mag, the "Insurgent" leaves little to the imagination.
Shoutout to all of the moms out there! Hardest, most rewarding & best job in the entire world!!!


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Front View larger Python 414 Remote start system with keyless entry Item #: 6074104P 4 Reviews This item is no longer available. Original Price: $199.99 Shop all Alarms & Remote Start Need help? 1.888.955.6000 Email Chat Ask an expert advisor No pressure, no commission — just lots of good advice from our highly trained staff.
by Ken Nail We offer vehicle-specific interfaces that you'll need to complete your remote start installation. Please identify your vehicle as we review every order to make sure you've got everything you need. Python's 414 remote start system will warm up your car on those cold winter days, and give you the ease and convenience of keyless entry. With a 2000-foot range, you'll be able to start your vehicle even when you're far away, and the stylish 1-way remotes look great on your keychain. Two long-range remotes The 414 remote start system comes with two transmitter remotes, and the 24-channel system always finds a clear channel. Manual Transmission mode allows you to use the system with your stick shift, while Smart Start cranks up your car when it senses low voltage or extreme heat or cold. Anti-grind circuitry prevents any damage to your starter motor. Four auxiliary channels The system sports four auxiliary channels so you can add options like horn honk and automatic defroster turn-on (additional relays may be required). The 414 system is compatible with BypassKit and XpressKit modules and accessories, which enable you to minimize your installation time in a wide range of vehicles. Important: If you know how to use a multimeter and have experience working with your vehicle's electrical system, you should be able to install this remote start system. If you're unfamiliar with installing car security equipment, please speak to an Advisor before attempting this installation. Note: Before purchasing, please call us at 1-888-955-6000 to confirm that this product works with your vehicle. Product Highlights:keyless entry/remote start systemtwo 5-button transmitters (24-channel) with 2000-foot rangeremote start can be configured for manual transmissionsRemote Start function is for fuel injected, diesel, and hybrid vehicles only4 remote-controlled auxiliary outputsonboard starter interrupt and dome light relaysparking light flash with short circuit protectionstarter anti-grind (starter interrupt must be installed)compatible with BypassKit and XpressKit modules and accessorieswarranty: lifetimeOur 60-day money-back guarantee
great company great tech support! Written By jc, NH on Tuesday, November 19, 2013 Xcellent cust service! Pros: Quality Cons: None
Python 414 Written By Anonymous, Houston TX on Monday, May 06, 2013 Crutchfield Customer Review (What's this?) Good, produts works perfectly
Python 414 Written By Barry S, Harleysville PA on Tuesday, February 26, 2013 Crutchfield Customer Review (What's this?) Easy installation. Crutchfield Tech Support is second to none! Thanks, Lloyd.
Python 414 with Xpresskit XK05 Written By GaryDB, Beavercreek, OH on Friday, December 07, 2012 Crutchfield Customer Review (What's this?) I have a 2009 Ford F150 Supercrew XLT. This product works as it is intended. This was my first install of a remote car start. Though the directions can be quite confusing I had Crutchfield's Technical Support to help me through it. If it had not been for the tech support and customer service I probably would have returned the product. Be sure to ask for pictures of where the wires for your install are and to first program the brain of the remote from manual to automatic or it will not work. Other than that I love my remote start. Pros: Great product, and does as intended. Technical support is awesome!! Cons: Long process of install but worth it in the end. Do it with at least 3 days off from work for you may need it.
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Space helmets and multi-coloured planes: A look back at Braniff International
We remember Braniff International before it hit bankruptcy.
Once upon a time there was an airline that flew passengers on jets painted in almost every colour of the rainbow, dressed its cabin crew in space helmets to protect their hairdos (think goldfish bowls) and reversible coats and made flying not just fun but fashionable.
Braniff International Airways was a Texas-based airline that came into its own in the 60s (despite being around since 1928) when most airlines were switching over from piston to jet engines.
With the jet age came the "end of the plain plane" as Braniff transformed its jets with pastel coloured paint jobs. Orange, beige and baby blue were 'in'. Designer Emilio Pucci unveiled new 'stewardess' uniforms that looked like something the Jetsons would wear.
There was no one uniform look. Cabin crew were given a capsule wardrobe of symmetrical outfits and multiple outfit changes were standard on flights –so the crew would sport a different look at boarding, meal times and on night and day flights.
And art that reflected its time graced the walls in gate lounges, ticket offices and aircraft cabins.
But it wasn't all style and no substance. Even economy (coach) passengers were given the royal treatment and had access to their own lounge on board Braniff's 747s.
But Braniff expanded too quickly and suffered from rising fuel prices and the Airline Deregulation Act in 1978, which opened the door to aggressive airline competition.
30 years ago this month, the airline sadly flew in the direction of many carriers today – into bankruptcy.
Braniff's brave "Air Strip" ad campaign
The designer uniforms that turned heads disappeared like they suddenly went out of fashion, along with the glamour of air travel, some fans say.
Would you like to see the return of Braniff International? Let us know below.


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Many children up to about the age of five will run into problems with stuttering. This is a completely normal stage of development and most children will outgrow it. For the ones who do not, stuttering can have an ongoing, profound affect on their lives.
Developmental stuttering is by far the most common type and begins in childhood and doesn't go away, continuing on into adulthood.
Neurogenic stuttering appears later in life, in a person who had no previous problem with it. It can be caused by a head injury or a stroke, or some other brain trauma. This type of stuttering is a relatively rare occurence.
If your child stutters, you can help them deal with it by being supportive and relaxed when they speak. Don't finish their sentences for them or display impatience or disapproval.
To make things more comfortable for friends who stutter, give them plenty of time to say what they are trying to say. Suggestions like "Relax," are in reality not relaxing. This just makes the afflicted person feel more self-conscious, and more pressured. And the outcome will probably be even more pronounced stuttering than before.
Some people who stutter find some relief from it in a few different activities. Some don't stutter when they sing, or recite. I was in a play years ago with a friend who stuttered. Except when he was saying his lines for the play. Then he had a beautiful speaking voice.
It may be helpful to see a speech-language pathologist (SLP). These are specialists in speech, language and voice disorders. For young children, early intervention with an SLP may help prevent some of the potential difficulties. But at any age, seeing an SLP may be helpful. They can provide different types of therapies which help the individual control their speaking patterns and habits.
Stuttering can sometimes be decreased by speaking slower, and by more controlled breathing. This also can help to ease the anxiety that so often occurs when a stutterer finds himself in a situation where he must speak. Reduced anxiety can sometimes reduce the tendency to stutter.
Stuttering is not a sign of lack of intelligence.
People here are talking about the Stuttering Foundation. I agree it is a great organization, but for different reason. I came to the U.S. from Ecuador at age 13. The speech therapy in Ecuador was terrible, if a child received any attention at all. It was tough to navigate the speech therapy channels when we first arrived.
The Stuttering Foundation has a Spanish-language version of its website at www.tartamudez.org to help both the Hispanic population in the U.S. and also people in Latin American countries, where speech therapy is lights years behind the U.S. I wish that such great info had been available to my parents and I when we came to the U.S. There are so many Hispanic parents in the U.S. who do not know where to turn to help their stuttering kids.
I also like the Stuttering Foundation because it sends its materials free of charge to about 125 countries each year, mostly underdeveloped nations. The organization holds summer workshops for SLP's in third world nations so that they can learn the newest techniques and bring them back to their countries.
My parents and I were lost for the first three or four years after coming to the U.S. We did not know where to turn for speech therapy. I also want to mention that the website of the Stuttering Foundation has a brochure called "Special Education Law and Stuttering" which explains that every child in the U.S. who is enrolled in any school has the right to free therapy, from pre-school throughout high school. This right to free speech therapy applies to kids with ALL speech problems and not just stuttering. Every parent should know about this right to speech therapy and I applaud the Stuttering Foundation for taking the initiative to help parents and kids with the various speech problems.
December 20, 2009 - 7:40pmGreat article, and Gloria and Bud got it right that The STuttering Foundation is a fantastic group to turn to for information and help. My bet is that everyone else got their information from this Foundation that has given so freely for the past 60 years. We are all in debt to the man, his wife, and family who are the reason we have this information!
Anne Smith
I agree with Gloria that everyone should know about The Stuttering Foundation and how to contact them. When my uncles were growing up, they were the only group around to help as we had no speech therapists in the schools like now. The internet was not around then, but they were reaching out to anyone they could help. They were started by a stutterer whose daughter has kept the Foundation going with the main goal of helping those who stutter. Read about them on this page http://www.stutteringhelp.org/Default.aspx?tabid=134.
Wonderful article about stuttering, but the oldest and best nonprofit source of help that was the biggest help for our family was left off! Everyone needs to know about The Stuttering Foundation where there are pages and pages of information, e-books, online videos, research articles, online newsletters, and lists of qualified speech therapists at www.stutteringhelp.org. This foundation offers some of their materials to public libraries so parents, teachers, employers, and stutterers have access to them. Their work making parents aware of how to help at home, when or if to see a speech therapist, and how teachers should treat a stutterer has made it easier for people who stutter. My child's life definitely would not be the same without this wonderful group. The foundation trains therapists to work with stutterers. For those who want to help everyone who stutters, this is where your donations are definitely well spent, too! You are helping to put more books and DVDs in every public library so more parents, teachers, and employers learn about stuttering and how to help.


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Gary's performance for Austin City Limits will re-air this Saturday (4/12) on PBS. Check your local listings for times.
Gary Clark Jr will be performing at THE FORECASTLE FESTIVAL this year. General admission and VIP weekend passes are on sale this Friday, March 7 at noon EDT. Travel packages and payment plans are also available. Full details can be found at http://ForecastleFest.com
Gary Clark Jr. will perform live at Summerfest in Milwaukee, WI on June 29th. Tickets go on sale 3/3. Click here for details and more information.
Just announced, Gary Clark Jr. will be performing at the The Hangout Beach, Music and Arts Festival on the beach in Gulf Shores, AL May 16-18. He'll be joined by The Black Keys, The Killers, Outkast, Troy "Trombone Shorty" Andrews & Orleans Avenue & more! For the complete lineup & tix go to http://www.hangoutmusicfest.com/
The Blues Foundation has nominated Gary Clark Jr for awards in 2 categories including "Best Contemporary Blues Male Artist" and "Best Instrumentalist - Guitar."
Winners will be announced on May 8th. For more information, visit http://blues.org/
Posted by GCJ WebCrew |February 18, 2014
Did you miss Gary's performance on The Late Show with David Letterman on 2/17? Click here to watch it now!
Esquire Magazine has said "Gary Clark Jr. Will Be A Rock God Soon." Click here to read the full article on Esquire.
Gary Clark Jr. will perform during the NBA ALL STAR GAME in New Orleans; singing the National Anthem AND performing at the halftime show alongside "Trombone Shorty," Janelle Monáe, Dr. John. and Earth, Wind & Fire.
The game will air live at 8pm EST on TNT and ESPN Radio.
Posted by GCJ WebCrew |February 06, 2014
Tune in to CBS on Sunday 2/9 For "The Night That Changed America: A Grammy Salute to The Beatles" where Gary will be performing "While My Guitar Gently Weeps" with Joe Walsh and Dave Grohl!


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Diamonds by the Yard, Silver Teardrops, and Open Hearts
For some of us, window shopping was the extent of our purchase power at Tiffany's. But when some of Elsa Peretti's elegant and fluid jewelry became part of Tiffany's collection at $250 and under, even modest incomes could afford to take part in the Tiffany tradition and bring home a magnificently crafted piece in a smart robin's egg blue box. Alas, recent reports have revealed that Peretti and Tiffany may be parting ways, eliciting many a frustrated sigh from aspiring plebeians everywhere.
Elsa Peretti, whose acclaimed pieces have been featured at Tiffany & Co., for nearly four decades, is attempting to end her relationship with the luxury retail jeweler, according to an U.S. Securities and Exchange Commission.
The two sides cannot agree on a price concerning Tiffany's recent bid to purchase the intellectual property rights of Peretti, according to the 8k report filed by Tiffany in advance of its first quarter earnings report this past Thursday. In the report, Tiffany stated, "If Tiffany ceases to have an exclusive license to use the Peretti Intellectual Property…operating results may be adversely affected." According to the filing, Tiffany stated it, "made a firm offer to Ms. Peretti in an amount that is based upon the value of the Peretti Intellectual Property to Tiffany."
Peretti's jewelry accounted for a significant portion in Tiffany's net sales, 10 percent in 2009, 2010 and 2011. Since 1974, Tiffany has been the sole licensee for the intellectual property rights (Peretti Intellectual Property); and Peretti, 72, receives a royalty for Tiffany's use of her property rights.
Both Peretti and Tiffany & Co., can terminate the agreement with written notice, and Peretti's counsel have intimated that the artisan may consider exercising her right to do so if both sides cannot come to an agreement. If Peretti terminates the license agreement, Tiffany's rights would include use of Peretti Intellectual Property rights for six months; and after the 6-month period, an additional year to sell Peretti-designed pieces it has on hand or on order.


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