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'Trojan Horse' particle sneaks chemotherapy in to kill ovarian cancer cells
12 September 2011
A common chemotherapy drug has been successfully delivered to cancer cells inside tiny microparticles using a method inspired by our knowledge of how the human immune system works. The drug, delivered in this way, reduced ovarian cancer tumours in an animal model by 65 times more than using the standard method. This approach is now being developed for clinical use.
Cancer cell (red and blue nucleus) that ingested two large microparticles (green)
Credit: Dr Davidson Ateh, BioMoti Limited
The research was funded by, among others, the Biotechnology and Biological Sciences Research Council (BBSRC) Follow-on Fund - funding for 'proof of concept' at the very early stage of turning research outputs into a commercial proposition - and carried out at Queen Mary, University of London. The study will be published next week in the journal, Biomaterials.
Dr Davidson Ateh, who worked on the research at Queen Mary, University of London and set up the start-up company, BioMoti, that will develop the technology for clinical use said "It's like we've made a re-enactment of the battle of Troy but on the tiniest scale. In Troy, the Greeks fooled the Trojans into accepting a hollow horse full of soldiers - we've managed to trick cancer cells into accepting drug-filled microparticles."
Dr Ateh and colleagues found that by coating tiny microparticles of around a hundredth the diameter of a human hair with a special protein called CD95, they could in fact trigger cancer cells into ingesting these particles. Not only that, but the particles could deliver a dose of a common chemotherapy drug called paclitaxel.
The key to their success is that CD95 attaches to another protein called CD95L, which is found much more commonly on the surface of cancer cells than it is on normal healthy cells. Once attached, the cancer cells ingest CD95 and the microparticle with it.
Inside the cell, the microparticle can unload its chemotherapy cargo, which kills the cell to reduce the size of the tumour.
Dr Ateh added "Other researchers had already noticed that cancer cells may use this CD95-CD95L arrangement to avoid being destroyed by the immune system, which is why they display more CD95L than normal cells. We've managed to turn this to our advantage and hijack the cancer cell's own trick-of-the-trade to get our 'Trojan Horse' through the gate."
Co-author and Professor of Gynaecological Oncology at Queen Mary, University of London, Iain McNeish commented "Chemotherapy is still the main way that we treat ovarian cancer, which can be particularly aggressive and difficult to treat. Anything we can do to concentrate the treatment in tumour cells and at the same time protect healthy cells is a good thing. This is an elegant method and if it works in a clinical setting as well as we hope it will patients could experience a better treatment with fewer side effects."
Principal investigator and Professor of Pathology at Queen Mary, University of London, Joanne Martin added "There are lots of drugs that we would like to deliver into cells - not just chemotherapies - and this could work for those too. For example, there are new classes of drugs to treat tumours, such as biological therapies. If we could load biological therapies into the same CD95-coated particles, then there's no reason why they couldn't also be delivered in this way."
The researchers are now advancing these studies and BioMoti is seeking to attract larger and established pharmaceutical companies to partner the technology, dubbed OncoJanTM in reference to the earlier Trojan horse, for the clinical development of new treatments in specific types of cancer.
Professor Douglas Kell, Chief Executive, BBSRC said "BBSRC funds a great deal of work that is aimed at improving our fundamental understanding of biological processes. When there are opportunities to use this understanding to the benefit of people, it is vitally important to seize and make the most of them. This is a good example where research into the human immune system has led to a new technology that has the potential to underpin health and wellbeing into later life."
Notes to editors
Ateh DD, et al.. The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles. Biomaterials 2011;32(33):8538-8547.
About Queen Mary, University of London
Queen Mary, University of London is one of the UK's leading research-focused higher education institutions with some 16,000 undergraduate and postgraduate students.
Amongst the largest of the colleges of the University of London, Queen Mary's 3,000 staff deliver world-class degree programmes and research across three faculties: Science and Engineering; Humanities and Social Sciences and the School of Medicine and Dentistry.
One of the rising stars in UK higher education, Queen Mary was ranked 11th nationally in the last Research Assessment Exercise, and was rated as one of the world's elite universities in the 2010 Times Higher Education's Top 200 World University Rankings (120th place).
The College has a strong international reputation with around 23% of students coming from over 130 countries.
Queen Mary has an annual turnover of £300M, research income worth £70M, and a yearly impact on the UK economy of over £750M.
Queen Mary, as a member of the 1994 Group of research-focused universities, has made a strategic commitment to the highest quality of research, but also to the best possible educational, cultural and social experience for its students. The College is unique among London's universities in being able to offer a completely integrated residential campus, with a 2,000-bed award-winning Student Village on its Mile End campus. For more information see: www.qmul.ac.uk.
About BioMoti
BioMoti Limited is a privately held UK based company engaged in the development of platform drug delivery technologies. In particular, BioMoti focuses on improving the delivery of active agents to the intracellular space. This is achieved by packaging the drug compounds into functionalised microparticles designed to access the interior of targeted biological cells. BioMoti is currently focussed on improving the delivery of drugs in cancer; helping to increase efficacy and reduce toxicity. Paired with the appropriate pharmaceutical agents, BioMoti technology can form a substantial portion of the worldwide market in the treatment of specific cancers by offering opportunities to target new intracellular mechanisms, reformulate compounds and contribute to the patent extension of marketed drugs. The total oncology market was worth over $50Bn in 2009 and strong double-digit growth is expected due to increased demand from an ageing population predominantly affected by cancer and the on-going need for innovative medicines. For more information see: www.biomoti.com. Contact: email@example.com.
About BBSRC
BBSRC invests in world-class bioscience research and training on behalf of the UK public. Our aim is to further scientific knowledge, to promote economic growth, wealth and job creation and to improve quality of life in the UK and beyond.
Funded by Government, and with an annual budget of around £445M, we support research and training in universities and strategically funded institutes. BBSRC research and the people we fund are helping society to meet major challenges, including food security, green energy and healthier, longer lives. Our investments underpin important UK economic sectors, such as farming, food, industrial biotechnology and pharmaceuticals.
For more information about BBSRC, our science and our impact see:
www.bbsrc.ac.uk .
For more information about BBSRC strategically funded institutes see:
www.bbsrc.ac.uk/institutes .
Matt Goode, Head of External Relations
tel: 01793 413299


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Every bride gets nervous before her big day and with the eyes of the world set to be upon her, it's no wonder Kate Middleton is feeling the pre-wedding jitters.
According to reports, Kate's anxiety is causing her to have vivid dreams… or naked nightmares to be precise.
The bride-to-be has been dreaming that she when she reaches the alter at Westminster Abbey, she is completely naked with the entire Royal family staring at her – a true blushing bride!
A Royal source told The Sun: "Kate has the last-minute jitters and just wants the day to arrive. It's hardly surprising considering the stage she is going to be on - with the eyes of the world on her.
"But her nerves have manifested in an interesting way. A recurring dream she hadn't had for years has raised its head again.
"She finds herself in front of the congregation and then becomes suddenly aware she is completely naked.
"There is a deathly silence - and everyone from the Queen to Prince Philip is staring at her."
Kate has been trying to calm her nerves by enjoying pampering sessions with her younger sister, chief bridesmaid Pippa.
The stunning girls were spotted enjoying facials at a spa, close to their parents Bucklebury home.

subset: commoncrawl


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The Chesapeake and Beyond: Paintings by the Washington Society of Landscape Painters
The Chesapeake and Beyond: Paintings by the Washington Society of Landscape Painters is a collaborative project by the Washington Society of Landscape Painters, the Chesapeake Bay Foundation, and the Arts Program at UMUC. The exhibit is designed to help publicize issues facing the bay, artistically showcase areas of the bay that are not often visited, and highlight artwork created by artists in our community.
Exhibit Dates
July 1–October 3, 2010
Arts Program Gallery
UMUC Inn and Conference Center, Lower Level
3501 University Blvd East
Adelphi, MD 20783
To request additional information, please call 301-985-7937.
Art Events
Helen Zughaib: Conflict Within
Exhibition Dates
Sunday, January 11–Sunday, March 29, 2015
Joseph Sheppard: On a Grand Scale
Exhibition Dates
Sunday, April 20, 2014–Sunday, March 29, 2015


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de Buyer Prima Matera Copper Saucepan
Made by de Buyer of France, the Prima Matera collection is the world's only copper cookware that performs flawlessly on all cooktops, including induction. These professional-quality pots combine the beauty and superior heat conductivity of copper with the easy care of stainless steel. High, straight sides keep ingredients inside the pan, while the wide cooking surface guarantees uniform browning. 2mm-thick contruction features 90% copper/10% stainless steel. Copper is a superior conductor of heat, ensuring highly responsive and uniform heating throughout pan. Seamlessly integrated magnetic bottom ensures induction compatibility. Stainless-steel interior offers easy cleaning and durability. Riveted handles of cast stainless steel stay cool to the touch. Made in France.
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Living in New York has its perks from time to time. Once you get over the crowds and the perpetual monetary black-hole that surrounds each of the city's inhabitants, it can offer a variety of interesting opportunities for the young and enterprising. One such example includes a breakfast our team was invited to this morning at the illustrious 21 Club. The breakfast was hosted by none other than everyone's favorite sports caster, Jim Nantz.
Nantz, as you may or may not know, is the voice of just about every sports cast on CBS. In fact, he is the only person to call the Superbowl, the Final Four, and the Masters all in the same year. He is also a best-selling author. Neither of these facts would get him a mention on Hodinkee however. The reason we are mentioning him today is that he also a Rolex Ambassador and the official voice of Rolex nation-wide. Yes, those Rolex commercials you see from time to time (typically during golf tournaments) feature Jim's voice.
So what kind of Rolex does the voice of Rolex wear? Well, in the past, he's been quoted as saying he prefers the President:
Maybe the 'President' is a bit formal, but it fits my personality. I'm a formal individual, a very busy person getting through all the clutter we've created in our complicated lives, and this watch allows me to be time efficient.
Today however, he was wearing a datejust. And it was NOT the same datejust he is wearing on the cover of his book. Although we can't say for sure, our guess is this guy has all the Rolexes he needs.
So what is the take away from this post? Not much really, just that it's really good to be a Rolex Ambassador. Also, we were really impressed with Nantz's candidness and ability to relate us normal-folk joining him for breakfast this morning. He told us some great stories (many of which we can't repeat), and we would like to thank both Jim for being such a gracious host and the 21 Club for supporting this event.
We were unable to find a Nantz-orated Rolex commercial online, but we did find this compilation that we really love. Click below to see some of why we (and Jim Nantz) love Rolex so much.


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Lyrics » David Wilcox Lyrics » Frozen in the Snow Lyrics |
Lyrics Depot is your source of lyrics to Frozen in the Snow by David Wilcox. Please check back for more David Wilcox lyrics. |
Frozen in the Snow LyricsArtist: David WilcoxAlbum: The Nightshift Watchman .............................................. I used to know a love song It was something about a flower That blossomed out to early When a sunny day turned sour Only for an hour There's a blossom in the snow The innocence is beautiful But what a way to go Chorus Frozen in the snow Singing Spring is coming Frozen in the Snow Now I was just a young thing When the sixties were in swing They were singing of Aquarius And all that it would bring A lot of dreams got frozen When the time turned bitter cold They blossomed like a flower But what a way to go Chorus Frozen in the snow Singing Spring is coming Frozen in the snow Frozen in the snow. .............................................. 1987 Midnight Ocean Bonfire Music/Nine-Ten Music, a division of Soroka Music Ltd. (BMI) All Rights Reserved/International Copyright Secured
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Bakesfield community honors student killed during Easter break
Student was not wearing seatbelt
BAKERSFIELD, Calif. - A Highland high basketball standout killed in a car crash over the Easter holiday was honored during an emotional memorial.
The service for 18-year-old Derrick Huff was held yesterday at Valley Bible Fellowship.
Duff was an MVP on Highland High's Varsity basketball team.
CHP said Duff was asleep in the backseat and not wearing a seat belt when the driver lost control of the Jeep and he was ejected.
A memorial fund has been set in Derrick Duff's name at Kern Schools Federal Credit Union.


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Globalisation, environmental economics, conservation and ecology, hurricanes, coastal geomorphology, the future of Africa and other developing areas, the geography of health, cultural differences - just some of the topics you can study on the Cambridge Geography course.
A wider world
All societies rely on relationships with each other and the physical environment. Increasingly these are fragile interdependences presenting intellectual and practical challenges. Our Geography course tackles these issues from a broad base, but also allows you to specialise.
Facilities and resources
We have one of the UK's largest geography libraries, containing around 17,000 books, journals and periodicals, and the Scott Polar Research Institute is an integral part of the Department. There are extensive computing resources, where you receive formal teaching in geographical information technology including geographical information systems and remote sensing, and the Department's intranet provides further online resources.
Fieldwork and travel
Fieldwork is an important part of our course and there are several one-day excursions and field trips in Years 1 and 2. A compulsory field class in Part IB leads to a piece of assessed practical work. Recent locations include Switzerland, Dublin, Berlin, Morocco and Mallorca. Some financial help is available but students are required to contribute to the cost of these field trips.
Your Part II dissertation requires basic research in the summer vacation at the end of your second year. Dissertation subjects and locations vary widely: some students travel abroad, others stay in the British Isles.
Many students organise their own overseas expeditions, often with the University Expeditions Society. Some Department and College travel awards are available for this.
While Geography isn't directly a 'vocational' degree, Cambridge Geography graduates are trained to deal with multivariate problems, are skilled in information retrieval, data management and computing, and are used to working on their own initiative, and as such are highly employable in a variety of professions.
Our graduates enter many different careers, including industry and commerce, planning, teaching, finance, social work, environmental management and conservation, the media, politics, and the Civil Service.
Course outline
You typically have six to eight lectures each week (with associated reading). You normally have three supervisions a fortnight at which you discuss a topic, usually following preparatory reading and essay writing. In the first and second years, you also have laboratory or practical classes, and field classes.
Year 1 (Part IA)
You're introduced to key themes and issues by studying two core papers:
- Human Geography – topics include globalisation; Fordism and welfare; ecological, economic and political perspectives on resources
- Physical Geography – topics include tectonics and volcanism, hydrological and geomorphological processes, atmosphere and climate
You're assessed at the end of the year by one written examination for each paper.
You also take the Geographical Skills and Methods paper that covers numerical methods; survey techniques; documentary and archival data; spatial data; and field, laboratory and desk-based skills.
Year 2 (Part IB)
All students take a core Geographical Ideas and Themes paper relating to global change, which is assessed through both coursework and written examination.
In addition, you can begin to specialise and select three papers from a choice of six, which are also assessed by a combination of coursework and examination. Each year, three human geography papers and three physical and environmental geography papers will be available. The lists below give examples of Part IB papers that may be offered.
Human geography
- Economic Geography
- Development Theories, Policies and Practices
- Citizenship, Cities and Civil Society
Physical and environmental geography
- Glacial Processes
- Biogeography
- The Coastal System
Building on Part IA Skills and Methods, you also undertake project work involving a range of field, laboratory and computer skills and techniques.
All students participate in a one-week residential field class during the Easter or summer vacation. This is essential for your final year dissertation research, both in terms of inspiring your choice of topic and in acquiring specific field research skills. A piece of submitted work on the field class forms part of your second-year assessment.
Year 3 (Part II)
You can either specialise further or maintain a balance across the subject as a whole. You select four papers from 12, which are assessed by either written examination or by a combination of written examination and coursework. Papers on offer vary each year but recent examples include:
- Imagining Europe
- The Human Geography of the Arctic Regions
- Political Ecology in the Global South
- Geographies of Discipline and Social Regulation in the Nineteenth Century
- Biosedimentary Coastal Systems
- Biogeography
- Glacial Environments
- Changing Cultures of Risk
- Volcanology
You also write a dissertation of 10,000 words on a topic of your choice, which you start work on during the summer vacation between your second and third years. The topic must be defined by the second term of Year 2 and the proposal is assessed as part of your second-year coursework.
Entry requirements
Typical offers require
A Level: A*AA
IB: 40-41 points, with 776 at Higher Level
For other qualifications, see our main Entrance requirements pages.
Course requirements
Essential No specific subjects
Useful An arts/science mix
There is no single combination of subjects that is especially good for students wishing to study Geography; the teaching programme for the course is broad enough to encompass those whose primary interests are in the humanities, the social sciences, the natural or the environmental sciences, or any combination of these.
It isn't even essential to have studied geography at A Level (although in practice nearly all our students have done so). If you are particularly interested in contemporary human geography or historical geography, then Economics, English Literature, History, and Sociology are useful (though not essential), as are courses in world development.
If you are interested in physical and environmental geography, then Biology, Chemistry, Geology, Mathematics and Physics are useful supporting subjects, as is Environmental Science. However, there is no distinction between 'human' and 'physical' geographers in terms of their GCE A Level subjects, as, for instance, an interest in studying the environment and global development issues typically calls for understanding of both social and physical sciences. Wherever your interests lie, though, knowledge of a foreign language will also help you understand developments in this international discipline, and to gain a greater insight into regional geographies.
Girton College encourage Mathematics to AS Level (or equivalent) though this is not essential.
Check College websites for College specific requirements. See also Entrance requirements and our Subject Matters leaflet for additional advice about general requirements for entry, qualifications and offers.
Admissions tests and written work
The table below sets out the ways in which each College assesses applicants for this subject. For more information about these methods of assessment and why we use them, see the main Admissions tests and written work page.
College | Assessment of applicant for this subject |
Christ's | School/college essays; Preparatory study at interview |
Churchill | School/college essay; Preparatory study at interview |
Clare | School/college essay; Preparatory study at interview |
Corpus Christi | School/college essay; Preparatory study at interview |
Downing | Preparatory study at interview |
Emmanuel | School/college essays; Preparatory study before interview |
Fitzwilliam | School/college essay; Preparatory study before interview |
Girton | School/college essay; Preparatory study at interview |
Gonville & Caius | School/college essays; Preparatory study at interview |
Homerton | School/college essay; Preparatory study at interview |
Hughes Hall | Interview only |
Jesus | School/college essay; Preparatory study at interview |
King's | School/college essay; Preparatory study at interview |
Lucy Cavendish | School/college essays; Test at interview |
Magdalene | School/college essays |
Murray Edwards | Test at interview |
Newnham | School/college essays; Preparatory study at interview |
Pembroke | Not available at this College |
Peterhouse | Not available at this College |
Queens' | School/college essay; Preparatory study at interview |
Robinson | School/college essay; Preparatory study at interview |
St Catharine's | Preparatory study at interview |
St Edmund's | Reading before interview |
St John's | Interview only; Interviewees will be asked to make comment on a graph/diagram |
Selwyn | Preparatory study at interview |
Sidney Sussex | School/college essays; Preparatory study at interview |
Trinity | School/college essay; Preparatory study at interview |
Trinity Hall | School/college essays |
Wolfson | School/college essay; Test at interview |
How to apply
If you are interested in applying for this course, please see our Applying section for more details.
Further Resources
Find out more about Geography at Cambridge
- Course website - Explore Geography in more detail on the course website.
- Course guide - A detailed guide to the Geography degree.
- Course FAQ - Some frequently asked questions about the Geography course can be found on the Course Guide page.
- Facilities - Some information about the facilities available to Geography students can be found on the Course Guide page.
Tools to help you with your Geography application
- Geography and your College choice - Information about College admissions and teaching can be found on the Course Guide page.
Geography and your future
- Career opportunities - Information about the careers opportunities available to you after studying Geography at Cambridge can be found on the Course Guide page.
The student experience
- Student profiles - Some current students describe their experience of studying Geography.
- CUGS – the student society - Find out more about the Cambridge University Geographical Society and what they get up to.
Unistats info
Contextual Information
From September 2012, every undergraduate course of more than one year's duration will have a Key Information Set (KIS). The KIS allows you to compare 17 pieces of information about individual courses at different higher education institutions.
However, please note that superficially similar courses often have very different structures and objectives, and that the teaching, support and learning environment that best suits you can only be determined by identifying your own interests, needs, expectations and goals, and comparing them with detailed institution- and course-specific information.
We recommend that you look thoroughly at the course and University information contained on these webpages and consider coming to visit us on an Open Day, rather than relying solely on statistical comparison.
You may find the following notes helpful when considering information presented by the KIS.
- The KIS relies on superficially similar courses being coded in the same way. Whilst this works on one level, it leads to some anomalies. For example, Music courses and Music Technology courses can have exactly the same code despite being very different programmes with quite distinct educational and career outcomes.
Any course which combines several disciplines (as many courses at Cambridge do) tends to be compared nationally with courses in just one of those disciplines, and in such cases a KIS comparison may not be an accurate or fair reflection of the reality of either. For example, you may find that when considering a degree which embraces a range of disciplines such as biology, physics, chemistry and geology (for instance, Natural Sciences at Cambridge), the comparison provided is with courses at other institutions that primarily focus on just one (or a smaller combination) of those subjects. - Whilst the KIS makes reference to some broad types of financial support offered by institutions, it cannot compare packages offered by different institutions. Different students have different circumstances and requirements, and you should weigh up what matters to you most: level of fee; fee waivers; means-tested support such as bursaries; non-means-tested support such as academic scholarships and study grants; and living costs such as accommodation, travel.
- The KIS provides a typical cost of private (ie non-university) accommodation. This is very difficult to estimate as prices and properties vary. University accommodation can be substantially cheaper, and if you are likely to live in College for much or all of the duration of your course (as is the case at Cambridge), then the cost of private accommodation will be of less or no relevance for you. The KIS also provides the typical annual cost of university accommodation and the number of beds available. Note that since most universities offer a range of residential accommodation, you should check with institutions about the likelihood of securing a room at a price that suits your budget. Knowing the number of beds available is not necessarily useful: it may be much more important to find out if all students are guaranteed accommodation.
- Time in lectures, seminars and similar can vary enormously by institution depending on the structure of the course, and the quality of such contact time should be the primary consideration.
- Whilst starting salaries can be a useful measure, they do not give any sense of career trajectory or take account of the voluntary/low paid work that many graduates undertake initially in order to gain valuable experience necessary/advantageous for later career progression.
The above list is not exhaustive and there may be other important factors that are relevant to the choices that you are making, but we hope that this will be a useful starting point to help you delve deeper than the face value of the KIS data.


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The Impotence of Proofreading
I found this on Rowan Manahan's blog, Fortify Your Oasis . It's so good that I had to share. Grammar nuts will especially appreciate this one.
3 Comments - Add yours!
Jeremy (May 11th, 2009)
Hah! Reminds me of the "pubic relations" firm that I applied to last year.
Mark Walusimbi (July 21st, 2009)
Great video.
How to avoid mistakes on your resume | Career Management Alliance Blog (November 1st, 2010)
[...] misspelled (such as manger), even though the main dictionary knows it as a proper word. Thanks to Lindsay Olson, who blogs about recruiting and PR, for sharing this fun video that she saw on Rowan Manahan's [...]
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this wiki
Ironhide | |||||||||||||||||||
Vital Statistics | |||||||||||||||||||
Alias | Pro (By himself) Old Timer (By Warpath) Old Friend (By Optimus Prime) | ||||||||||||||||||
Species | Cybertronian | ||||||||||||||||||
Rank | Captain of the Ark | ||||||||||||||||||
Status | Unknown | ||||||||||||||||||
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Production details | |||||||||||||||||||
First appearance | War for Cybertron | ||||||||||||||||||
Voiced by | Keith Szarabajka |
- "That's what ya get for pickin' the wrong side!"
- ―Ironhide after killing a Decepticon.[src]
Ironhide is a Autobot veteran, who is one of the toughest among Autobots. As one of Optimus Prime's closest and oldest allies, he saw great potential within his leader and was more than happy to smash Decepticons with his fists.
Ironhide seems to have a good relationship with Warpath, teaching him a thing or two about combat while being called old timer, something which irritates him often whenever he said that.
War for Cybertron
Ironhide led a squad of Autobots to defend the Decagon during the Decepticon invasion of Iacon. With the loss of Zeta Prime, Ironhide's old friend Optimus was forced to take command of the Autobots, an act that the old soldier approved, as he was glad that Optimus was finally stepping up to take his rightful place in the Autobot hierarchy. After helping Optimus and his team by clearing a path for them to the Decagon (and taking down two Brutes, tearing one in half), he continued to lead the others to (successfully) push the Decepticons into retreat. After Optimus became Optimus Prime, Ironhide and Warpath joined him on the mission to clear the core of Cybertron that was infected with Dark Energon. Ironhide constantly rebuked the young, aggressive Warpath's shoot-first attitude. Heading to the Omega Gate, the three Autobots found Omega Supreme being tortured with Dark Energon. Freeing the massive Autobot, Ironhide joined Optimus and Warpath in protecting Ratchet long enough to repair Omega to the open the Gate. Heading underground, the three Autobots found space slugs working to clear the Dark Energon crystals. When they were sealed off in a cavern, another slug came in and killed an attacking Decepticon, to which the old, knowledgeable Ironhide offered the universal greeting, but the slug simply ignored them and moved on with its task. The three Autobots then found a trio of slugs with Ion Displacer turrets on their backs, and provided cover fire for the slugs as they made their way through Cybertron. Unfortunately, a corrupted space slug attacked the trio, knocking them underground and killing the slugs. Regrouping at the core, they were attacked by the corrupted slug, and managed to defeat it. Unfortunately, the Dark Energon corrupted the Core, which could only purge the corruption by shutting down all systems, leaving Cybertron uninhabitable and forcing the Transformers to leave Cybertron. Before departing, Ironhide and Warpath witnessed Optimus receive a part of the Core's essence, the Matrix of Leadership. As the evacuation went underway, Megatron used his orbital station to attacking fleeing transports. A group of Aerialbots under Silverbolt managed to shut down the station's cannon, only to learn that the station itself was a Cybertronian named Trypticon. Ironhide joined Optimus and Bumblebee in finishing off the monster. Though many Autobots managed to escape, a number of them, Ironhide included, stayed behind to fight against Megatron's schemes. Optimus commissioned the building of a new starship, the Ark, to take the Autobots from Cybertron, wherever they may go.
Cybertron Adventures
Ironhide and Bumblebee were tasked with retrieving information from a Decepticon datacore about the "Trypticon" weapon. They nearly managed to make a successful getaway from Kaon before Megatron and Soundwave arrived, dropping the Autobots in the streets. Ironhide was shackled and imprisoned, whie Bumblebee was scheduled for interrogation under the neural scanner. A lucky power outage during an Autobot raid freed Ironhide from his bonds, and he raced through the detention facility to rescue Bumblebee before the scanner forced him to reveal military secrets. He found the kid, but not before some data was lost to the scanner. On the way out of the prison, the duo were radioed by Air Raid, who offered to provide air support during their escape. Thanks to his creative use of firepower, they were able to escape down a road that had previously been a dead end. Later, Ironhide returned the favour by providing comm support to Air Raid, who was using the data recovered on Trypticon to block the power supply running between Trypticon and the Geosynchronous Energy Bridge. He plotted Air Raid's course through the Decepticon controlled tunnels near the Bridge. After Trypticon Station fell to Cybertron's surface and revealed itself as a gi-normous transforming creature, Ironhide joined Optimus Prime and Bumblebee in racing to the crash site to finish him off. They were separated during the journey, and had to fight through multiple Decepticon vanguards before even reaching Trypticon. Eventually, it was the combined firepower and teamwork of the Autobot forces that brought down the dangerous dinosaur. Ironhide was ready to kick back with some lubricant, but Optimus reminded him that the war was far from over.
Fall of Cybertron
Ironhide was one of the many Autobots involved in the construction of the Ark. During the invasion of Iacon he led a squad of soldiers to defend the Ark's fuelling station which was being attacked by tanks. The battle was not in his favour until Optimus took control of a Neutron Gun turret and later activated Metroplex, destroying the tanks. After Metroplex defeated Megatron, Ironhide was dismayed to learn the Energon saved for the Ark was gone. Later, Jazz reported that he, Cliffjumper and Sideswipe had found an entire reservoir of pure energon that was sufficient to power the Ark. Ratchet then inquired as to how to transport it. After Optimus denied having Metroplex carry it back Ironhide suggested using an old refinery transport. Perceptor argued that the transport guzzled too much energon and Ironhide rebutted that it had the firepower they would need and thus his plan was approved. When the Decepticons attacked the Ark on its way to the portal opened by Shockwave's Spacebridge, Ironhide took part in the battle. At one point he called for air support, saying that one of the blasts fired from the Decepticons had, "Taken a toll on Optimus." His status is left unknown.
Optimus Prime
Ironhide and Optimus are very close to each together, and was proud to see him be the leader of the Autobots after Zeta Prime's death.
Ironhide and Ratchet don't interact much, but it is assumed they have a stable relationship.
Ironhide and Bumblebee don't interact much, but they seem to trust one another while fighting Trypticon.
Ironhide is annoyed by Warpath, and wants him to be more careful. Warpath constantly calls Ironhide "old timer." Warpath also thinks Ironhide is jealous of his "fine aim" but according to Ironhide,"he can't be jealous of something he doesn't have."
Ironhide and Grimlock aren't seen together at all in the game, but Ironhide is angry when Grimlock deserts his post.
Video Games
- "War for Cybertron" (Debut)
- "Fall of Cybertron"
- "Rise of the Dark Spark"
Novel Series
- "Exodus"
- "Exiles"
- "Retribution"
- Originally, Ironhide was to star in that of Transformers: Prime. However, Ironhide's death in Transformers: Dark of The Moon caused the writers to think twice about using him and to avoid confusing children, they instead chose to place Bulkhead in his role despite the fact that Transfomers: Dark of The Moon is not in the same continuity. Despite Ironhide not making an appearance in the show, Bulkhead seems to pass down Ironhide's traits.


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Journal Menu
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- Table of Contents
Journal of Amino Acids
Volume 2011 (2011), Article ID 517137, 5 pages
Research Article
Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis
1Saint-Petersburg Institute of Bioregulation and Gerontology, RAMS pr. Dinamo 3, St. Petersburg 197110, Russia
2I.P. Pavlov Institute of Physiology, RAS, Makarova emb. 6, St. Petersburg 199034, Russia
Received 16 May 2011; Revised 6 July 2011; Accepted 12 September 2011
Academic Editor: Udupi A. Ramagopal
Copyright © 2011 V. Kh. Khavinson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- A. A. Yarilin and I. M. Belyakov, "Cytokines in the thymus: production and biological effects," Current Medicinal Chemistry, vol. 11, no. 4, pp. 447–464, 2004. View at Publisher · View at Google Scholar · View at Scopus
- N. I. Sharova, A. D. Donetskova, I. V. Dubrovina, G. T. Sukhikh, and A. A. Yarilin, "Expression of regulatory T-lymphocyte phenotype in human fetal hemopoietic and lymphoid cell culture," Bulletin of Experimental Biology and Medicine, vol. 141, no. 4, pp. 524–529, 2006. View at Publisher · View at Google Scholar · View at Scopus
- V. O. Polyakova, I. M. Kvetnoy, S. S. Konovalov, P. N. Zezulin, and I. V. Knyazkin, "Age-related differences in expression of signal differentiation factors for human thymic epithelial cells," Bulletin of Experimental Biology and Medicine, vol. 144, no. 2, pp. 235–237, 2007. View at Publisher · View at Google Scholar · View at Scopus
- V. K. Khavinson and V. G. Morozov, "Peptides of pineal gland and thymus prolong human life," Neuroendocrinology Letters, vol. 24, no. 3-4, pp. 233–240, 2003. View at Scopus
- I. M. Kvetnoy, V. O. Polyakova, A. V. Trofimov et al., "Hormonal function and proliferative activity of thymic cells in humans: immunocytochemical correlations," Neuroendocrinology Letters, vol. 24, no. 3-4, pp. 263–268, 2003. View at Scopus
- V. N. Anisimov and V. K. Khavinson, "Peptide bioregulation of aging: results and prospects," Biogerontology, vol. 11, no. 2, pp. 139–149, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. I. Grigor'ev, V. K. Khavinson, V. V. Malinin, A. E. Grigor'ev, and T. A. Kudryavtseva, "Role of aqueous medium in mechanisms underlying the influence of immunoreactive peptides ultralow doses," Bulletin of Experimental Biology and Medicine, vol. 136, no. 2, pp. 150–154, 2003. View at Publisher · View at Google Scholar · View at Scopus
- V. Kh. Khavinson and V. V. Malinin, Gerontological Aspects of Genome Peptide Regulation, Basle, Switzerland, Karger, 2005.
- I. M. Kvetnoy, J. Hernández-Yago, J. M. Hernández, T. V. Kvetnaia, R. J. Reiter, and V. Kh. Khavinson, "Diffuse neuroendocrine system and mitochondrial diseases: molecular and cellular bases of pathogenesis, new approaches to diagnosis and therapy," Neuroendocrinology Letters, vol. 21, no. 2, pp. 83–99, 2000.
- T. Yamamoto, S. I. Morita, R. Go et al., "Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus," International Journal of Radiation Oncology Biology Physics, vol. 77, no. 1, pp. 235–243, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- V. Kh. Khavinson, N. S. Linkova, A. V. Trofimov, V. O. Polyakova, N. N. Sevostyanova, and I. M. Kvetnoy, "Morphofunctional fundamentals for peptide regulation of aging," Biology Bulletin Reviews, vol. 1, no. 4, pp. 389–393, 2011.


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text:
So, I just got done re-reading probably my 3rd favorite book ever, Sphere, by Michael Chrichton.
Basically, it's about this psychologist, Norman, who's 53. He get's flown in to this random place in the Pacific Ocean, North of Australia, and finds out that he's about to be put on a mission. To find aliens.
This is based on a paper that the government had commisioned him to write 6 years earlier, on what to do if we ever contacted aliens. He thought it was a joke.
But, he finds out that beneath the ship they've flown him to, 1000 feet down, there is a gigantic spaceship, 1/2 a mile long, many feet wide, in a cylinder shape. They think aliens are there.
So, Norman, along with a team he had proposed in his alien paper, descend down, to an underwater habitat, 33 atmospheres of pressure.
They live there for a few days, looking at the spacecraft, and they go in.
They find out it's American, from 2048, and had time traveled backwards.
Weird. They're discovering a ship that won't be built for 50 years (when the book was written).
Anyway, they find out that the ship's mission was to travel through space and time, and find aliens.
The crew of the ship is long dead, but, they find out that either before or after they died, they ship picked up something.
A gigantic sphere.
10 yards diameter.
Perfect, flawless, polished, pristine in every way.
Except for some weird markings on one side.
A quote: "On the far side, they discovered a series of deep, convoluted grooves, cut in an intricate pattern into the surface of the sphere. The pattern was arresting, though Norman could not immediately say why. The pattern wasn't geometric. And it wasn't amorphous or organic, either. It was hard to say what it was. Norman had never seen anything like it, and as he continued to look at it he felt increasingly certain this was a pattern never found on Earth. Never created by any man. Never conceived by a human imagination.
He felt sure of it.
This sphere was something alien."
The find that the pattern is a door, of some sort. The sphere is hollow.
They spend like the rest of the book trying to figure out how to open it, and when they do, it nearly kills all of them.
But, I almost would have preferred it stay closed. A perfect mystery. A giant, perfect sphere. Alien, possibly floating in space for thousands of years. Made of unknown, indestructible material. And there is something inside. It's a GREAT mystery, one that I just LOVE to ponder...
That one seems better unsolved, because once you figure out how it got to be in space, how old it is, who or what it was made by, what's inside, and everything else, then it's boring.
It's just another part of life.
I like to savor the mystery.
and i think we do because on some level, the unsolved/ unknown intrigues us.
Mental wounds not healing, driving me insane, i'm goin' off the rails on a crazy train- the ozzman
And, at first glance, I'd like nothing more than to find out everything about that sphere.
But, that would take away all the mystery.
That's one that I think should never be solved.
Maybe a real life example is better, such as the Mad Trapper of Rat River:
Way way up in Northern Canada, this guy in some town had his bear traps being set off by someone. He calls the mounties, and he says it might be this guy, he lives over here.
The mounty goes over, and tries to talk to the man at his house, but the man just sits there, and doesn't acknowledge him.
He comes back with a buddy, and then the man starts shooting at them, with still, no words.
They come back with more and more mounties, until they have 14. They still can't kill the guy. So they use dynamite, and blow up his cabin.
Later, when going through the rubble, they find that he'd actually dug a bomb shelter, and escaped.
Thus starts one of the largest manhunts in Canada's history. The Mad Trapper heads West, towards Alaska. No matter how many mounties they send out, they can't find him.
In the middle of winter, he reaches the Richardson mountains. They figure he can't possibly make it over, so they block the passes, and figure that he has to have died in the mountains when they can't find him.
He reappears on the other side of the mountains. Somehow, he'd done what no one else ever did, crossed the mountains in the middle of winter, and didn't even use a pass. He had to have like climbed over a mountain. Imagine.
They employ a plane, big money in those days. (1920's)
They find his campsites, and follow his trail. They find him with the plane, and start shooting. They shoot him 9 times, before he finally falls down dead.
He was found with thousands of dollars in cash, and not much else. No one knows who he was, how he got where he was, how he got that money, or anything about him.
During the whole manhunt, no one ever heard the Mad Trapper say one word, or any verbalizations.
I think that that is a MUCH better story, if we didn't know "oh well, his real name is Joe Bob, and he comes from a middle class family in Nebraska."
I think it's way better to imagine.
Hai-kus are ea-sy
But some-times they don't make sense
that was actually a true story though...there is a charles bronson movie based on it. can't remember the name, but yeah. lol.
it is much better than knowing for sure.
Mental wounds not healing, driving me insane, i'm goin' off the rails on a crazy train- the ozzman
...by following an innate drive to solve mysteries; their very survival required this talent.
btw... I'm currently working on your new avatar/icon. But, don't worry... my survival is not dependent upon its solution :)


text: With the release of the Big L documentary Street Struck right around the corner, Jewlz (the film's director) put together an official tribute video featuring Mike Boogie who was featured on 8 Iz Enuff. Big up to Big L Online, Jewlz, Mike Boogie and everyone else involved. Big L R.I.P.


text:
All meetings are open to the public.
Third Thursday of each month at 5:30 p.m.
Council Chambers in Mayfield Heights City Hall
Phillip R. Miller, Chairman
David Spehar
Christopher Panichi
Vladimir Macek, Alternate
Tom Jamieson
Anne Weiland
440-442-2626 x210
For more information visit the Mayfield Heights Building Department.
We recommend that you check with City Hall on the day of any meeting you plan to attend
because of possible cancellations and summer recess.


text:
�Beginning early March 2015, the GWAS Catalog infrastructure will be migrating to the European Bioinformatics Institute (EMBL-EBI). Content prior to this time will continue to be available on this NHGRI web page, but additional content updates will be limited.�We will provide updates here as they are available; interested users can receive e-mail updates from firstname.lastname@example.com. To subscribe, please send an e-mail to�firstname.lastname@example.com with subject heading "subscribe."
Update (2/19/15):� Curation of GWAS papers will be temporarily on hold beginning 2/20/15 while the GWAS Catalog infrastructure transitions to the EMBL-EBI.� We expect curation to resume in early March, at which time updated content will be available at EMBL-EBI.
Current uses of and future directions for the Genome-Wide Association Studies Catalog
On Thursday, July 18th, 2013, the Division of Genomic Medicine held a webinar to highlight current uses and explore� priorities and future directions for the GWAS catalog. See archived video and presentations.
The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
Click here to read our recent article from the Nucleic Acids Research Database Issue.
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
Click here to read our Proceedings of the Academy of Sciences (PNAS) article on catalog methods and analysis.
The genome-wide association study (GWAS) publications listed here include a primary GWAS analysis, defined as array-based genotyping and analysis of 100,000+ pre-QC SNPs selected to tag variation across the genome and without regard to gene content.� GWAS data from published studies which are incorporated into new GWAS analyses are eligible, provided they meet the other criteria.� Studies imputing sequencing data to genotyping arrays are eligible as long as the arrays include sufficient genome-wide coverage so that the post-imputation analysis meets the definition of a GWAS analysis, as described above. Customized gene-based arrays without a clearly described GWAS backbone, including those selected to replicate published GWAS findings (e.g., Metabochip, Immunochip, etc.) are not eligible.� Publications are organized from most to least recent date of publication, indexing from online publication if available. Studies are identified through weekly PubMed literature searches, daily NIH-distributed compilations of news and media reports, and occasional comparisons with an existing database of GWAS literature (HuGE Navigator).
Gene names and risk alleles are those reported by the authors in the original paper. Only one SNP within a gene or region of high linkage disequilibrium is recorded unless there was evidence of independent association.
Occasionally the term "pending" is used to denote one or more studies that we identified as an eligible GWAS, but for which SNP information has not yet been extracted; studies of CNVs are also noted as pending
How to cite the NHGRI GWAS Catalog:
Hindorff LA, MacArthur J (European Bioinformatics Institute), Morales J (European Bioinformatics Institute), Junkins HA, Hall PN, Klemm AK, and Manolio TA. A Catalog of Published Genome-Wide Association Studies. Available at: www.genome.gov/gwastudies. Accessed [date of access].
How to cite the NHGRI GWAS Catalog paper:
Welter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H, Klemm A, Flicek P, Manolio T, Hindorff L, and Parkinson H. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Research, 2014, Vol. 42 (Database issue): D1001-D1006.
To view the PDF on this page you will need Adobe Reader.
To view the MS Word file on this page, you will need MS Word. You can download a free copy of the latest version of Word Viewer from Microsoft.
The Excel documents on this page require MS-Excel or a free Excel viewer.
As of 02/20/15, the catalog includes 2111 publications and 15396 SNPs. |
Last Updated: February 20, 2015


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text: El Domingo, 6 de Mayo de 2007 01:37, Justin R. Knierim escribió: > I like it too, good work. As the ftp maintainer, I haven't been able to > update the hlfs packages in a while because of having to manually update > it from the book and/or commit messages (which not all get through to > the list, etc). Is there an possibility of a wget list to be generated, > preferably per book version or if needed, all packages in one list? > Then I can get the ftp repo scripts plugged into that and we can have > updated hlfs packages again. Done. Running make wget-list you will have under ~/hlfs-book/ a wget list file for each one of the four master book flavours. -- Manuel Canales Esparcia Usuario de LFS nº2886: http://www.linuxfromscratch.org LFS en castellano: http://www.escomposlinux.org/lfs-es http://www.lfs-es.info TLDP-ES: http://es.tldp.org


text:
The information in a petition must be submitted in good faith and comply with the law. Each petition will be considered on an individual basis and it will be open to the County Council to exercise discretion in how it responds.
a) Anybody who lives, works or studies in the Administrative county of Hampshire and is over the age of 13 will be able to raise a petition asking for an action to be taken by the County Council;
b) Any matter raised with the County Council that identifies itself as such will be dealt with as a petition, which may include issues relating to partner organisations;
c) If a petition raises issues that relate to a partner organisation, the petition will be considered on an individual basis to determine which organisation is best placed to respond and the petition organiser notified;
d) Details of the petitions received, number of signatures and the responses provided will be published on the County Council's website;
e) Petitions will be acknowledged within five working days with a response or details of the action being taken provided within 20 working days of the acknowledgement letter;
f) If a petition is not being considered under the scheme, the reasons for this will be included in the response;
g) Responses to petitions will be appropriate and proportionate to the issue raised;
h) Petitions of 32,000 signatures (circa 2.5% of the population of the Administrative county of Hampshire) or more may request for a matter to be debated in full Council or request that an Executive Member or senior office attend a meeting of the relevant Select/Overview and Scrutiny Committee;
i) If a petition organiser does not consider that the response of the County Council has been adequate, they can request that the matter be referred to the relevant Select/Overview and Scrutiny Committee.
Some issues will not be an appropriate channel for a petition. In order to avoid duplication, the policy areas of planning and licensing are excluded as are other matters where there is a statutory right to a review or appeal (except where there is an alleged failure of the County Council in respect of one of its functions).
Petitions initiated by Hampshire County Council employees where the subject matter relates directly to their employment or to their immediate area of responsibility are also excluded. This would cover matters where another right of recourse exists (e.g. the grievance procedure).
Petitions are not the right route for Freedom of Information requests; information about the FOI procedure can be found on the Freedom of Information web pages. Other routes to bring matters to the County Council's attention may be more appropriate and more information is available on the Have Your Say web pages.
Petitions which are considered by the Head of Governance/Monitoring Officer to be vexatious, abusive or otherwise inappropriate will not be accepted. Any petition rejected for these reasons will be formally reported to the Cabinet.
Petitions cannot target individual members of a community or County Council officers for reasons that do not relate to their role at the Council.
In the period immediately before an election or referendum petitions may need to be dealt with differently. If this is the case the reasons for this and the revised timescale which will apply will be discussed with the petition organiser.
a) potentially libellous, false, or defamatory statements;
b) information which may be protected by an injunction or court order (for example, the identities of children in custody disputes);
c) the names of individuals, or information where they may be identified, in relation to criminal accusations;
d) material which is potentially confidential, commercially sensitive, or which may cause loss or personal distress without justified cause;
e) any commercial endorsement, promotion of any product, service or publication;
f) the names of individual officials of public bodies, unless they are part of the senior management of those organisations. There is a complaints process available for disputes relating to the actions of individual officers and petitions regarding a County Council Officer must relate to their role in delivering public services and not their character, personality or private life;
g) the names of family members of elected representatives or officials of public bodies;
h) language which is offensive, intemperate, or inappropriately provocative. This not only includes obvious swear words and insults, but any language to which people reading it could reasonably take offence;
i) petitions that are substantially the same as an existing petition or petitions that have been submitted in the last 12 months;
j) petitions which ask for things outside the remit or powers of Hampshire County Council to influence;
k) statements that don't actually request any action;
l) wording that is impossible to understand.


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Spring is just around the corner (I hope!) and soon the markets will be brimming with fruits and vegetables. Carry your produce in style with these Jute Market Totes from No More To Go. Enter to win these two lovely totes today because the giveaway ends January 23.
Archive for the 'Purse Deals' Category
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Add a touch of whimsy to your fall with the Radley London Mid-Season Sale! Shop now and get up to 50% off selected styles. My personal favorites are the Leather Leaf Medium Grab Bag and the Taplow Large Shoulder Bag.
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Celebrate the birth of the new British prince by shopping one of our favorite British brands, Radley London! Through tomorrow at midnight, get some of your favorite Radley purses and wallets for up to 70% off. My personal picks are the Grosvenor, down from $455 to $227, and the Persley, down from $379 to $189.
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Shop Boden's spring sale and and you can snag several of their bright, happy, perfect-for-spring bags for up to 40% off! Hop on over to Boden because the sale only lasts through the weekend.
Additional Discounts at the Kate Spade Sale
If you've got any Christmas money left, head on over to the Kate Spade sale where they are now offering an extra 25% off all sale items. Just enter the code 25SALE at checkout to get the discount. My two favorites are the Washington Street Treesh and the Deborah Dot Little Nadine. Hurry because the sale ends January 6.
Target x Neiman Marcus Collection Now 50% Off
I am not sure that if in the midst of the holiday rush whether or not you've had the chance to check out the Target x Neiman Marcus collection. Designers like Tori Burch, Oscar de la Renta and Marc Jacobs created lower priced items to be sold exclusively at Target. When the collection debuted, I think the general consensus was that it was overpriced. Nothing flew off the Target shelves in my town. Now the entire collection is 50% off in stores and online. I just ordered the Carolina Herrera Travel Bag set, which had caught my eye in the store. Originally $39.99, I got it for $19.99 with free shipping. Here are some other great items from the collection, which may be worth it at 50% off.


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Built with an adjustable elastic headband, the Baker Head Lamp provides super-bright, hands-free lighting that's perfect for low-light tackle prepping, fishing, or hiking. The Baker Head Lamp is built with 5 LED light bulbs that have a running life of 100,000 hours and are virtually unbreakable. Additionally, the Baker Head Lamp has two running modes (stead-on or blinking), and a magnetic backing that can be removed for attachment to any steel surface. Whether you're hooking up your boat in the early morning hours or doing some night fishing, the Baker Head Lamp is the best way to keep your hands free and your surroundings bright.
Please Note: Head Lamp requires 3 AAA batteries (not included)
No customer feedback has been added yet! Be the first to write something about this product.
***Note: If you have questions about this product or need assistance with an order please email your questions to email@example.com


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My Heart Remembers - eBook
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Format: DRM Protected ePub Vendor: Bethany House Publication Date: 2008 | ISBN: 9781441202321 ISBN-13: 9781441202321 Availability: In Stock |
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My Heart RemembersKim Vogel SawyerBethany House / 2008 / Trade Paperback$11.99 Retail:5 Stars Out Of 5 52 Reviews
$15.00Save 20% ($3.01)Availability: In StockCBD Stock No: WW202629
Publisher's Description
Author Bio
In this book, the reader watches as the Gallagher children grow up, begin their relationships with God, and live their lives, but always wondering if they will ever be together again. The only things they have connecting them are the family Bible, some letters written from their father to their mother, one family photograph, and their ties of love to each other. Nevertheless, those bonds are so strong, they remain despite time, distance, and ill fate.
This book is a must-read for people who are interested in drama and faith. The author shows a segment of history from an emotional and human perspective, rather than just a statistical recording of events. The youngsters on these trains experience multiple levels of trauma because of death, family separation, personal injury, poverty, and abandonment. The Scriptures say that those who reach out to these desperate children and offer them shelter, food, clothing, and nurturing are following biblical mandates. Christ said that even a cup of cold water given in His name would be righteous service to him. The love of friends and family cannot be discounted in the effort to bring the Gospel to those who need it most, and this story shows such love in action. The author makes history come alive through vivid scenic descriptions, powerful dialogue, and strong plot pacing. -- Alyssa Crager, www.ChristianBookPreviews.com
Product Reviews
bookloverHarrisville, NYAge: 45-54Gender: female5 Stars Out Of 5a very good storyNovember 29, 2013bookloverHarrisville, NYAge: 45-54Gender: femaleQuality: 5Value: 5Meets Expectations: 5This is a very nice story. It keeps you interested as it goes. Maelle is quite an interesting young lady. I liked her inner spirit. She never gives up. I enjoyed reading this.
Robert Shipley5 Stars Out Of 5GrippingSeptember 28, 2011Robert ShipleyQuality: 5Value: 5Meets Expectations: 5The product of "Orphan Trains", this book will keep you in suspense throughout. The contrasts are amazing.
Jagster66ArkansasAge: 35-44Gender: female5 Stars Out Of 5Very upliftingSeptember 20, 2011Jagster66ArkansasAge: 35-44Gender: femaleQuality: 5Value: 4Meets Expectations: 4This book was very hard for me to put down. It is an easy read, touching in many places and helps us to realize that God takes a bad situation and shows us His plan, in His time. I have recommended it already to many friends...
Elizabeth Cain5 Stars Out Of 5Very touchingDecember 24, 2010Elizabeth CainQuality: 5Value: 5Meets Expectations: 5This review was written for My Heart Remembers.This book captured me from the beginning. The strength, determination and love in the characters is beautifully written. There are moments I wanted to cry with the characters. The scenes and emotions that come from them are amazing. A great read for sure.
Sharyn NobleCape Paterson AustraliaAge: 55-65Gender: female5 Stars Out Of 5June 5, 2010Sharyn NobleCape Paterson AustraliaAge: 55-65Gender: femaleThis review was written for My Heart Remembers.I really enjoyed this story. It was well researched informing the reader about the train orphans and the fight to stop child labour. A touching story that brought tears to my eyes. Will be passing this one on to my non christian friends.
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Kathleen Kinsey, Design Consultant
"I worked very closely with Kathleen Kinsey and it was a pleasurable experience. Kathleen and I designed this room to my liking. My experience with California Closets was fun and satisfying and all my needs were met." - Cherie M., San Jose | "Kathleen was easy to work with and patiently listened to our closet organizational needs even as we kept learning what they were. Her final design is delightful and it is a treat every time we step into our new master bedroom walk-in closet. The materials used are far superior to the other brands of closet organizing companies. We loved having the closet completely installed in just one morning's time since we are in the middle of an extensive remodel." - Suzanne W. | "They did a good job and that's not the only job they did for me." - Susanna Y. | "The closets are completed and look perfect. And Nathan is worth his weight in gold. Marc and I realized that so often these days, work is done so poorly that we've almost come to expect that as the norm. Our experience with California Closets has been exceptional in every way. The people who man the phones are pleasant and courteous. Meeting and working with you, personally has been a pleasure. And meeting Nathan and seeing the attention to detail and the pride and ownership he took in his work, made for a 100 percent positive experience. Appointment times were met. And my hall was left clean and vacuumed. I am a happy gal! I will definitely recommend California Closets to my friends and neighbors. " Debbie S, San Jose | "We love the closet - it came out really nice. The bamboo on the doors looks really wonderful too! My shoes are so happy to finally have a place to sit!" Anjuli M., Los Altos |
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I look at each new project as a puzzle with a creative solution. By combining my experience, a customer's thoughts and ideas, and use of space, I am always amazed with the results.
My favorite part of being a designer for California Closets is having conversations with people about their challenges and what led them to contact us. Getting to know my clients allows me to understand their organizational needs. The California Closets process is very much a joint effort between the designer and the client. From the initial consultation to the installation, we collaborate on all decisions.
I especially enjoy designing bedroom closets. I have California Closets systems throughout my own home and I can honestly say, it makes life so much easier. When I get dressed everyday, it easy to find everything and my day starts off in the right direction.


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Kristin Glazner graduated in philosophy and journalism in 1999. Kristin obtained her JD at IU School Law and worked until recently at Baker & Daniels. In 2010 Super Lawyers selected Kristin as one of Indiana's "Rising Stars," a distinction aimed at recognizing the top up-and-coming lawyers in Indiana.
She wrote the following opinion piece for the Butler Collegian:
There I was staring at a computer screen page. The page was filled, but it wasn't that great. It was the beginnings of my honors thesis.
I guess I should mention initially that writing a thesis is painful, but I am sure quite rewarding. I am at the beginning stage. I am still finding it painful.
Anyway, I was pondering deep thoughts while looking at the computer. I got frustrated and called up a friend. His first question is what is the paper about. I start with "It is a philosophy thesis..." And he interrupts me. He scolds, "Why are you studying philosophy?" You know, that is a good question, but what is more interesting is why does it get asked. No one would ask a chemistry, biology, or business major that question.
Philosophy just doesn't get enough credit. Dave Barry described philosophy students as they students that do drugs, take long lunches, and talk about nothingness. That is a hard stigma to crack. Philosophy is simply about viewing the world a bit differently. It is about asking the tough questions and wrestling with the answers. More people should give philosophy a chance. It is not so bad, especially at Butler.
There is Dr. Dulckeit, the quick-witted German department chair with heels; Dr. van der Linden, very funny and from the land of tulips and cheese; Dr. Beversluis, the most relaxed and pleasant man you will ever meet; and Dr. Stuart Glennan, who is on sabbatical so I do not need to butter him up for awhile. They are all funny. They are all brilliant. And they all are worth taking a class from.
Now, what about getting a job and being a philosophy major? Should Mom and Dad be nervous about junior's future? Philosophy teaches you how to think. Not what to think, but how to think. In a technological era where everything is outdated once it is created, thinking skills are the only things that will last. It is also the single best major to study if you are interested in going to law school. Philosophy majors test higher on the LSAT than any other major.
So, that is why I study philosophy. And hell, being a philosophy major sounds impressive. So for all you undecided students, take a philosophy class. It is a funky major.


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As the application outsourcing contract is signed, you need to rapidly acquire and transfer the technical knowledge from your client to your team without damaging the quality of the delivery to the business.
The CAST Application Intelligence Platform (AIP) provides knowledge transfer automatically to baseline the application portfolio with qualitative and quantitative metrics, helping identify those applications at risk that need to be completely documented. You can then use CAST to generate detailed technical documentation of the modules at-risk or applications where the risk has been identified because of:
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VOTE 2010: Prentis Benston wins sheriff's race in Bladen CountyThe Bladen County Sheriff's race has been intense between the supporters for both candidates. WWAY's John Rendleman caught up with both candidates once the race was decided Tuesday night. Disclaimer: Comments posted on this, or any story are opinions of those people posting them, and not the views or opinions of WWAY NewsChannel 3, its management or employees. » |
Recent comments


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After spending the night comforting Chris, Rihanna was seen leaving his home with him and showing up to his court hearing on Feb. 6. She was even in the courtroom with him and they walked out arm-in-arm!
No matter how much trouble Chris Brown gets himself into, Rihanna is determined to stand by her man. After being accused of faking his community service on Feb. 5, Chris was called to a Los Angeles court on Feb. 6, where he faced District Attorney Mary A. Murray over claims that he logged an incorrect record of community service hours, therefore violating his probation from his 2009 assault on Rihanna.
Rihanna Attends Court With Chris Brown
Rihanna, 24, and Chris, 23, were seen leaving Chris' house at 12:00 p.m. Pacific time on Feb. 6, where they were heading for the courthouse, reports x17 Online. Rihanna was wearing a patterned shirt with a bunch of chains, while Chris was wearing a cap, a jacket and track pants, but thankfully he was carrying a suit over his arm, as can be seen in the pictures on X17.
They walked into the court together and Rihanna blew Chris a kiss. Then they walked out of the court room arm-in-arm just a few minutes later.
Rihanna is seriously supportive of her man! Not only is she accompanying him to his hearing, she also spent the previous night with him, in order to distract him from his legal troubles. Rihanna and Chris were seen leaving a recording studio at 4:30am, where Rihanna comforted him following his "day of hell."
Chris is expected back in court on April 5.
Chris' Instagram Rant
As previously reported by HollywoodLife.com, Chris went on an Instagram rant following these new accusations:
"I'm wise I can handle the hate but enough is enough yo!! Yes it bothers me but it's not my main focus! My music is…and when I speak on it… it's because I want people to know how I feel."
"I'm a human being and I honestly think I deserve respect, I'm sick of being accused. I'm tired ya'll just don't understand I've been going through this s**t since I was 19 years old … you can't sit here and tell me to calm down, when am I gonna get a positive outcome out of anything I do? … When can I get that feed back? I'm TIRED do you read me I'm tired!!!!! I'm not gonna sit here and play the victim, I'm just tired of this s**t … I pray every day and night for a new outcome … and just when everything seems to be going good some new s**t happens."
Yikes! Let's hope Chris has calmed down before he reaches the courtroom. Perhaps that's why Rihanna is joining him, as she has a positive effect on him.
Stay tuned to HollywoodLife.com for more updates on Chris's hearing.
What do YOU think, HollywoodLifers? Do YOU think Rihanna was wise to accompany Chris to court?
Watch: Chris Brown Shows Up To Court with Rihanna!
– Eleanore Hutch
More Chris Brown In Trouble News:
- Chris Brown's Lawyer: Prosecutors Have 'Completely Lost Their Minds'
- Chris Brown Threatened To Shoot Frank Ocean During Fight — Report
- Chris Brown Respects Frank Ocean & Decision To Not Press Charges
View Comment
Posted at 11:30 PM on February 7, 2013
Posted at 6:44 PM on February 7, 2013
@kiki: I think that old ugly hag sandra has so much time in her hand to argue back and forth with you because she is old enough to retire…lol. She tells you to get an education while she has so much time in her hand to argue with every single person on the blog and correct people's spelling…damn I don't even have that much time…I wonder if sandra even has a job or in a relationship..maybe she's an old whore like rihanna…drugs can do that to you you know…sandra is trying to relive her hoeish love life through chris and rihanna…that's why she's fighting for rihanna so hardddd…kiki,while you and me are actually IN a relationship so we don't have to live in a fairy land like sandra…I bet you sandra watches the soap operas and cry with a tissue box by her damn self…lol.
henrietta mbunwe
Posted at 11:31 AM on February 7, 2013
Posted at 11:05 AM on February 7, 2013
Posted at 7:52 AM on February 7, 2013
Posted at 9:42 AM on February 7, 2013
sandra duncan
Posted at 12:02 PM on February 7, 2013
TRUST ME you can continue being DELUSIONAL. Just because you are 25 and UNEDUCATED doesn't mean the rest of the world is like that. I have 25 year old friends who are currently working on their masters degree if your #BASIC a** even know what that is. STAY BASIC B****!!!!
sandra duncan
Posted at 11:58 AM on February 7, 2013
Behaving how? It is my GOD given right to have FREEDOM OF EXPRESSION now you want to dictate to me how I should behave. That is what's wrong society too judgmental it is OK for someone to behave a certain way when you think it is appropriate. Well you know what YOU CAN KISS MY A**. I hope that is more appropriate for you.
Posted at 5:00 AM on February 7, 2013
Posted at 4:22 AM on February 7, 2013
Posted at 1:11 AM on February 7, 2013
Posted at 11:10 PM on February 6, 2013
Posted at 10:16 PM on February 6, 2013
What rant……sounds like he was telling how he feels. But Wait! Chris Brown doesn't have an IG account he deleted his well over a week ago. Seems like another lie on the behalf of the media and opinionated a**holes who love to judge other people but have more skeletons in their closet than he ever would.
Posted at 10:06 PM on February 6, 2013
@dUNCAN Jus shut the fck up,as everybody on these blogs who don't stand for RIHOE is literate to you purely cus they are making the odd spelling mistakes here and there.
Comprehension dont mean fck all as there are plenty of dyslexic ppl in this world who are doing just fine and are not in fact stupid ppl alot of them are quite intelligent
.And you aint 28 darling try adding another 20 odd yr onto that your jus an old woman tryna relive your life through this blog website
sandra duncan
Posted at 10:49 PM on February 6, 2013
You know what I am going to let you stay being #KAELUSIONAL if you think you saying I am an old lady affects me think again. On that note try going back to school it will benefit you in the long run. #NO SHADE. You are an average looking girl and an education will help you out because you won't get far with your looks. lol
Posted at 9:45 AM on February 7, 2013
Posted at 11:44 AM on February 9, 2013
Posted at 9:38 PM on February 6, 2013
what's done today is a shame rihanna today laughed of battered women and their fans
karrueche is a lady and rihanna should learn of karrueche
rihanna is staining his image and she is sinking his career
But nobody gonna talk about how stupid and dumb she look sitting there ?
Rih was stupid for agreeing to be there. It makes her look stupid to her young fans who used to respect her
Posted at 10:19 PM on February 6, 2013
Posted at 11:53 AM on February 7, 2013
Rihanna's presence did not laugh at battered women. Her presence stood for love, forgiveness and change. If you love Karrueche then you must love Chris cause all you know of her is via him. If you love him then you care that he's changed a lot over the years and is trying to be a better man. You'd appreciate the love and forgiveness his journey has taken and you'd respect the fact that he and Rihanna never stopped loving each other, even during their other relationships.
Keep in mind that Karrueche was with him after 2009 so by your reasoning she stood against and laughed in the face of battered women by even being with Chris. Karrueche stood by him when he was hurting his career, fighting in interviews & on twitter, throwing chairs through windows and fighting in clubs over another woman (that wasn't K). Chris was hurting too while he was in a relationship with Karrueche; about his career, his growth, people's perception of him and because he couldn't be with the love of his life.
I think that you really need to access your anger toward Chrianna in general. Seems like you've been mad at R since 2009 (blaming the victim). Many of us didn't choose to hate when 2009 happened but it seems you did. You throw out the "battered woman" thing but ignore what K did by dating a batterer on the heels of his battering another woman.
Truth is people like you destroy Chris's image. You continually questions his thinking, motivation, constantly bring up 2009 and just can't be happy for his happiness and support him when he needs it.
Posted at 11:58 AM on February 7, 2013
Susie K
Posted at 11:52 PM on February 7, 2013


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You've probably heard the expression, "Perception is reality," implying that if you believe something, it may as well be true. But with mobile payments, that often isn't the case.
The reality is that mobile credit card transactions are safe and secure. But the perception of many consumers is that this payment method is vulnerable to hacking or that security systems can be easily compromised. As a business owner, it is your duty to assuage your customers' fears and explain to them why their credit card information is well-protected and how it is kept out of the reach of unscrupulous individuals.
Here are two big ways you can work to change customers' perception regarding the security of your mobile payments transactions.
- Inform them about the specific safety features provided by your mobile payments system - First, credit card data is encrypted three times when swiped through the credit card reader, making it nearly impossible to capture. Second, credit card data is never stored on your mobile device, so even if the device is lost, there's nothing for a thief to abscond with. Finally, the electronic receipt you send to the customer only contains the last four digits of the credit card number.
- Display your compliance with PCI standards - GoPayment keeps all of its security infrastructure in compliance with Payment Card Industry Data Security Standards [PDF]. You can demonstrate this by affixing a PCI sticker to your digital device, checkout counter, or store window. Customers will increasingly see these stickers, and they'll increasingly give shoppers more peace of mind about your mobile payments system.
In addition, here are a few tips on how to further improve the security of your mobile payments system.
- Password-protect your device - If you misplace your digital device or it's stolen, unauthorized users won't be able to access your GoPayment account if the device requires them to enter a password.
- Authorize other users on your account - If other employees will be accepting mobile payments from customers, set up their own account instead of letting them use your account. Managing permissions this way gives you more control, and lets you quickly revoke access when an employee leaves.
- Enable your geolocation feature - Most digital devices include GPS features. In conjunction with GoPayment, geolocation tracking engages when you process a GoPayment transaction and documents the physical location where the payment took place. This gives you a record of where all mobile payments transactions actually occurred, so you can easily pinpoint the location where unauthorized transactions may have occurred.
By employing these measures, you can work to enhance your customers' perception of mobile payments and bring them closer to the reality that they are indeed safe and secure.


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Photo submitted by David McCunn. Taken at one of Tohei Sensei's first visits to Iowa City, between 1979-1981.
2nd row: [?], Richard Reed, [?], [?], Steve Beck-Montgomery, Jerry DeWees, Barb Boyd Brown, [?], [?]
1st row: [?], [?], [?], Tom Yates, Akira Tohei, John Breno, Jon Dalrymple, [?]
Can you identify any of the other people in this photo?
If so, let us know. Email us at: firstname.lastname@example.com
Page last updated: 09/02/04


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Watch award-nominated movies
It's award show season! Catch up on critically acclaimed movies before the winners are announced - On Demand and streaming.
Rumors have been swirling about who would be directing Guardians of the Galaxy since its announcement in July. This has been Marvel's biggest question mark in the post-Avengers phase of their mega-successful films.
Given the source material about an alien police force that includes a tree and a raccoon, many thought it an impossible task to mesh a film version of the offbeat comic with the rest of the Marvel Cinematic Universe. The choice would have to be nigh perfect.
And while Joss Whedon all but cemented his choice for director of the space adventure film in a recent interview, the chosen one only today revealed himself via his Facebook. James Gunn will officially be helming Guardians of the Galaxy.
"As a lifelong lover of Marvel comics, space epics and raccoons, this is the movie I've been waiting to make since I was nine years old," Gunn said on his Facebook page. "Kevin [Fiege , Marvel President], Joss and all the folks at Marvel have been amazing collaborators so far, and we're committed to bringing you something majestic, beautiful and unique."
Given the fact that Gunn has heretofore only made quirky indie and sci-fi films like Super and Slither, many are questioning Marvel's decision. But those who are fans of his films, as Whedon and Fiege are, believe such a far-out director is the perfect, and perhaps only, choice for such a far-out film.
Guardians of the Galaxy opens August 1, 2014.