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No Trivia's Friday Five: Danny Brown Peps Up Purity Ring
Plus, Cardo rewrites Rustie, a mix from Cities Aviv, Quelle Chris gets ratchet, and Gunplay's beer-spilling mania
Jacked up on too much coffee and a great new Kanye song, there's no way you're getting complete thoughts, here. Give Mr. Muthafuckin' eXquire credit for working with Gucci Mane, who he's a lot like, really. Give him even more credit for recording a song called "Telephuck," with a soundwave that if you check it out in Soundcloud, looks LIKE A GIANT BONER. Make sure you check out DJ Burn One-approved rap-funk-fusion jazzbos iNDEED, whose album streamed here last week and is now available for download. "Double Cup Etiquette" is a swooping something-like-a-love-song (to a lady who can hold her liquor, to drank, to old Willie Hutch-style Southern soul). Of course, Burn One would sample a track from Hutch's 1977 kinda-disco album, Havin' a House Party. Why doesn't Lil Twist's Diplo-produced single "Flowerz" sample the Armand Van Helden song of the same name? How great would that be? Curren$y's "Jet Life" actually getting some radio play is refreshing. Freddie Gibbs and Kirko Bangz's "Bout It, Bout It" should, as well. Can't recommend Steven A. Clark's Fornication Under Consent of the King enough. Late by a week, but oh man, Billy Corben's ESPN 30-for-30 doc Broke! It was more interesting than good (no momentum due to its reliance on nothing but talking heads), but it's an important story that should be told. There easily could be a rapper version of the movie. Plus, Broke felt particularly poignant after reading Jessica Hopper's Kendrick Lamar piece, which features a picture of the rapper munching cereal on his momma's couch, and revealing that he has spent very little of his million-plus contract on himself.
One more thing for those of you in New York. Next Thursday, me and a bunch of other music writers are spinning rap music from our hometowns for charity! Yes, myself, Zach Baron, Rembert Browne, Julianne Escobedo Shepherd, Corban Goble, Luke McCormick, and Puja Patel (who organized this thing) will be at Arrow Bar (85 Avenue A) to benefit locally grown after-school music organization Bigger Than Hip-Hop, Building Beats, and Dance Theatre Etcetera. You'll be politely asked to kick in a few shekels at the door, if you could. And please do. It's for charity, jerks!
Cardo, "2050"
Cardo, best known for working with Wiz Khalifa and Freddie Gibbs, releases an instrumental beat-tape, Everything Is Gold, with Fool's Gold, and takes on the candy-colored, tangly, taffy-rap rush of Rustie and Hudson Mohawke. It is the trap sound that bounced across the pond — starting with Girl Unit's "Wut," really — and returned as "trap rave" refixed by a laid-back West Coast beatmaker gone future-funk. Major points for that "My Sharona"-esque drumming — a rhythm Quentin Tarantino once called "a butt-fucking beat" — stupidly pounding through the whole thing. Other than most of this trap-rave junk just being another hipster redundancy, it doesn't seem like that big of deal. What David Drake over at Complex said in his thoughtful piece, "Real Trap Sh*t? The Commodification of Southern Rap's Drug-Fueled Subgenre" is correct, but the term "trap" has simply stomped past T.I. and Young Jeezy, and now means a specific production style. One that rose up from Atlanta at the same time as a similar-sounding, rickety robot strain of dubstep rose out of London. It only makes sense that they would start conversing. As long as we have guys like Cardo to answer back, I wouldn't worry too much.
Cities Aviv, Total Indulgence Mix 2012
The first song on this 30-minute mix from Memphis noise-rapper Cities Aviv is an even more dire take on the Iron Curtain's "The Condos." Towards the end, there is a previously unreleased, and vicious grindcore-meets-DJ Screw blast of rage from No Gang Colors, who are sort of the inverse of Cities, in that they make rap-tinged metal, rather than metal-tinged rap. The rest of the tracks, I'm not sure what they are, but it all sounds like the sort of thing Sacred Bones Records should be releasing, if they haven't already: Factory smoke-caked, sad-sack post-punk that's ready to fight and bite you if need be, but would probably prefer to curl up in the corner and be left alone. More than anything, Total Indulgence Mix sustains a feeling of things on their last legs, of people not winning, of stuff totally sucking. When I saw Cities at the Hopscotch Music Festival last month, I was shocked by his move away from curious, curatorial boom-bap to what I declared "rap as pigfuck." This mix seems like another move in that direction. Black Pleasure, the follow-up to Digital Lows, is out next month.
Purity Ring, feat. Danny Brown, "Belispeak II"
Danny Brown attacks "Belispeak," from Renaissance Faire-in-space, dirge-pop duo Purity Ring, and turns all their arch, Ursula LeGuin-ian nonsense about witchcraft and grandparents and just plain bad lyric-writing ("Grandmother, my sleep is narrow") into a breathless rap about being poor as shit and hungry as fuck. He clearly listened to the original and considered it, making sure some of his content overlaps, but he also pulls the song out of the realm of the fantastical, where way too many indie kids are fortunate enough to reside: "Raised in the gutter, I ain't really have nothing / No silver spoon, I was raised on rusty shovels / Granny used to tell me, 'Boy, stay up out of trouble' / But the hunger in my tummy had me staying on my hustle." Then, Danny turns to a touching rhetorical: "Now, tell me have you ever, ever, ever in your life / Did something wrong and you know it wasn't right?" It is, well, a hybrid of Brown's poetic poverty tale spewing on The Hybrid, and the avant-Waka shout-rap that made XXX both fun and harrowing. A Purity Ring x Danny Brown collabo shouldn't work, but it does. Credit to Purity Ring's Corin Roddick, for having the stones to gently Auto-Tune Danny Brown's vocals to make a slightly more manic version of his own song, and for answering Brown's Twitter calls to collaborate in the first place.
Quelle Chris, feat. DJ GroWeyez, "Rat Shit"
Latarian Milton, age 7, back in 2008 on the West Palm Beach news, when asked why he stole his grandmother's car: "It's fun to do bad things. I wanted to do hoodrat stuff with my friends." Juicy J, age 37, in 2012, on "Bandz a Maker Her Dance," his inexplicable radio hit: "You say no to ratchet pussy, Juicy J can't!" Quelle Chris has some fun with this ratchet-music trend on "Rat Shit," muttering a list of hoodrat shit (or "hoodrat things" as young Mr. Milton put it) over a bubbling, bass-heavy beat: "Hangin' out at the liquor store (rat shit) / Call your baby momma a hoe (rat shit)"; "Going straight to the club after church (rat shit)." The beat, though, seems to be making a different point altogether, connecting the sonic dots between the minimalism coming out of the West Coast right now, and techno (Detroit resident Chris' hometown contribution to dance music), by sounding like some lost Cybotron single. At its core, "Rat Shit" is typical underground snark, for sure, but Chris is having fun with it, and like the best rap parodies, it's hard to distinguish from the real, sincere, thing. It's like something Chris Rock would do with Prince Paul, if they were still making ambitious comedy albums together.
Rick Ross, feat. Gunplay & Rockie Fresh, "Clique"
Gunplay, the guy with the swastika tattoo on his neck, has the best verse on Rick Ross' The Black Bar Mitzvah mixtape. Of course, he does. It's almost as if Gunplay exists as much as Ross' living breathing street cred as he does a grinning, towering reminder of where and how Ross' music fails, even when it succeeds as street-signifying wish-fulfillment spectacle. That Gunplay's "Bible On The Dash," one of the most introspective rap songs of the year, is tossed onto the end of this shoddy mixtape seems perverse. Then again, so does the entire existence of Rockie Fresh, who, in an act of cognitive dissonance typical for an MMG signee, jokes on this song, about Kreayshawn's crappy record sales, even though he will never have a hit as big as "Gucci Gucci," or probably even put out an album that will get the chance to fail miserably. Back to Gunplay: "Yeah, I spill my Coors on your Michael Kors, whore / Yeah, so the fuck what? I could buy you more." Right there, in two ignorant-ass lines is the dude's Tony Montana-in-"Say goodnight to the bad guy"-mode appeal. He's sipping Coors, being an obnoxious asshole, knows who Michael Kors is, what wearing it means, and can spot someone wearing it. He also has the bills to pay for some expensive dress he just ruined with his cheap beer. Yesterday, Gunplay turned himself in for armed robbery. That guy.


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Drupal, Web Design
We've been honored to work with Marriage Equality USA on their Drupal-powered site.
Work so far has included:
- designing new sidebars and nested drop-down menus;
- standardizing typography and content structure throughout the site; and
- tweaking CSS as needed.
We look forward to future collaboration with this important civil-rights organization.

subset: commoncrawl


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POSTED: Wednesday, September 21, 2011 - 3:01pm
UPDATED: Friday, April 13, 2012 - 8:54am
UPDATED: Friday, April 13, 2012 - 8:54am
A Bellmead woman is being held on four new sexual misconduct charges.
19-year-old Amanda Rachelle Murnahan was accused of sexual misconduct with a 10-year-old girl in 2009.
She now faces two more aggravated sexual assault counts and two indecency with a child counts.
She's in the McLennan county jail on an $850,000 bond.
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Join this unlikely pair of Shadow Creatures, on an epic metaphysical journey to escape their own nature and find a greater meaning. Read more
Join this unlikely pair of Shadow Creatures, on an epic metaphysical journey to escape their own nature and find a greater meaning.
About this project
- - New Funding Goal: $8,000 - -
We've reached our initial goal of $4,000. Thanks to all of the kind people who made a pledge! We honestly can't thank you all enough!
This original goal was set up as the bare minimum we would need to finish Crowman & Wolfboy. More funding would greatly help us in both production and marketing. With a strong marketing budget, we will be able to spread the word more effectively (buying ad space and setting up booths at conventions like PAX and E3), thus helping our game to be more of a success. With success in Crowman & Wolfboy, comes growth in Wither Studios, allowing us to continue to make unique experiences for you to enjoy :)
If we can reach at least $8,000 we will have a more solid starting point to work with. It would help us to:
· Create better quality music (see FAQs for more detail)
· Buy additional software, instead of renting software
· Bring the game to other platforms such as Android and Steam
· Provide future updates to the game with more content and levels
· Give us a better marketing budget to work with and much more!
Thanks again to all of our backers!
-The guys from Wither
- - More Videos - -
Join this unlikely pair of Shadow Creatures, on an epic metaphysical journey to escape their own nature and find a greater meaning. You'll flee the planet of shadows and travel across the universe itself, discovering amazing new worlds along the way. Nothing will stop Crowman and Wolfboy from finding the Truth!
Art Style
The game has a cartoonish style, with a unique personality. We love games where you travel to different environments and wanted to push that idea even further in our own game. So our artists created OVER FIFTEEN amazing environments! Most iOS games brag about having four or five. Crowman & Wolfboy visually progresses as you get further into the game as well. This supports the concept of the characters traveling to and witnessing new worlds. The planet you start on is void of any color, but as you leave this place you'll be introduced to beautiful, colored landscapes and fantastical settings.
Our game finds a unique balance between the simplicity of popular iOS games and the depth of beloved classic adventure and platformer games. We've replaced the virtual D-pad with a mechanic that is more intuitive and gives more control to the player. In most of the current iOS Platformer and Adventure games, you'll notice they also have virtual buttons (i.e. "A" and "B" buttons). We've done away with these buttons all together to really streamlined the players experience and interactions.
Another unique feature is that our main character is actually made up of two characters, that act as one. They need each other to survive this incredible expedition. Crowman uses his abilities to jump, glide and dive; while Wolfboy uses his abilities to smash, dig and climb. With their combined skills, they will be able to conquer any obstacle that stands in their way.
There are also sections of the game that break up the gameplay to provide a nice sense of depth and fulfillment for the player. In these levels, you'll be falling through the air and flying through space in different rocket ships! All done with a straightforward tilt and tap control scheme.
We're about halfway through development at this time. The team is shooting to be at the Beta Testing phase by the end of this year. So as far as a release date, we are looking at early 2012. A more concrete date will come a little later, right now our primary concern is making this game as awesome as we can :)
Wither Studios, LLC
This company became an LLC in 2011, though it was originally founded in 2009 by Steve Gabry and John Cobb. Driven by our passion for art, storytelling and of course video games, nothing would stand in our way of achieving our dreams. Two short years later Wither Studios is now a team of seven extremely talented artists and programmers. We cannot wait to share our art and the experiences we create with the world!
Everyone loves prizes! Pledge today and get some awesome limited edition Crowman & Wolfboy Gear! (see the list to the right for details)
Remember, Kickstarter is all or nothing. That means, if we don't reach our goal we get zilch!
If we reach our funding goal on Kickstarter, it will allow us to fulfill the essential development costs. Below is a list of what the money will go towards.
· Software Licenses
· iOS Developer License
· Legal Fees
· Web Hosting and Marketing
If we raise over $4,000 that would assist production even more and help us create an even better experience for you to enjoy! Below is a list of what any extra money will go towards.
· Music Production
· Additional Software
· Porting our Game to Android
· Bringing you more Updates with more Content and Levels!
· Better Marketing, to help reach more people
To all of the amazing people who made a pledge, we Thank You from the bottom of our hearts! You are helping us achieve our dreams, and that means the world to us. We hope you enjoy your prizes and more importantly our game.
If you couldn't make a pledge, we hope you'll still follow us on Facebook and give our game a try when it comes out ;)
We've put all of our savings and months of hard work into this project. Now we are out of money and need your help! You'll become part of our history, in helping our small indie team get its feet off the ground. Plus, there are cool prizes that we are only producing for Kickstarter. So they are all limited edition!
Some or our team members are also talented musicians, on top of being game developers. We will be collaborating with a few members of a local Pittsburgh band to create some awesomely unique music. Very specific plans for something new is in the works. A little extra funding for this department would help us produce higher quality music (better recording devices, studio time, etc). Stay tuned for updates on this, when the time comes.
Development is being geared towards iOS devices. Meaning Crowman & Wolfboy will be released for iPhone, iPod Touch and iPad. We would also love to eventually port the game to Android; but that all depends on funding and/or how well the game does on iTunes.
Pledge $1 or more
7 backers
Thank you! Every little bit counts :)
Estimated delivery: -
Pledge $5 or more
115 backers
FREE copy of Crowman & Wolfboy when it comes out!
Estimated delivery: -
Pledge $25 or more
16 backers
FREE copy of Crowman & Wolfboy when it comes out and the Goodie Bag! This includes a limited edition Sticker, Wristband and four pack of Buttons!
Estimated delivery: -
Pledge $50 or more
12 backers
The above prizes, plus you get your name in the credits of Crowman & Wolfboy! You also get a special Poster!
Estimated delivery: -
Pledge $100 or more
5 backers
All of the above prizes, plus you get a special T-Shirt and the opportunity to become a Beta Tester! This means you'd get to test the game before it's released as well as provide input that could potentially help make the game better.
Estimated delivery: -
Pledge $250 or more
1 backer
All of the above prizes, plus a limited edition Hoodie!
Estimated delivery: -
Pledge $500 or more
4 backers
All of the above prizes, plus a custom made Crowman & Wolfboy iPhone Skin! And! FREE GAMES FOR LIFE! This means that any game we ever make, we'll send you a copy! For Free!
Estimated delivery: -
Pledge $1,000 or more
0 backers Limited (3 left of 3)
All of the above prizes, plus a limited edition Art Book! Since you're so awesome, we've also made you a One-Of-A-Kind, Original work of Art!
Estimated delivery: -
Pledge $2,000 or more
0 backers Limited (1 left of 1)
All of the above prizes, plus a secret and amazing Mystery Prize! What could it be?! :)
Estimated delivery:
Funding period
- (36 days)


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Thursday, November 12, 2009
Simplicity Crib Instructions Bed to Crib
I had posted on Fixya.com about the Simplicity Crib Instructions Bed to Crib and I have now included a link to the photos on the right side of my blog or here Simplicity Crib Instructions Bed to Crib
I got these from someone else that emailed them to me who currently sells them on ebay for $3.00, I decided mine should be for free. I have gotten about 100 emails and have returned them all but I am kinda of tired of doing that.
15 comments:
- Jason said...
Thanks for sharing the instructions Leslie. I've been looking all over to find these with no luck until now.
Jason in MD - November 27, 2009 at 5:18 PM
- leslie said...
Your welcome, I like that someone actually posted it and didn't just take it without saying anything.
- November 29, 2009 at 7:28 PM
- Cara said...
Thanks for sharing!
- January 3, 2010 at 7:49 PM
Thanks for sharing Leslie!
- June 2, 2011 at 10:59 PM
Thank you for posting these! I've been looking for an hour and finally came upon your site. Much appreciated!
Lauren - July 2, 2011 at 9:17 AM
Thanks for posting! In my quest to find the instructions, I found out that the company is now closed and every crib they made has been recalled. My daughter is almost 3, and I was looking for the instructions so that she could transition into her Big Girl Bed. Now we have to try to resolve this. Grrrr!
- July 25, 2011 at 7:37 PM
Omg! I found it yay!!! I've been trying to put this damn crib up for 3days now. Thank you !!!!
- July 25, 2011 at 8:24 PM
Thank you for the instructions....
- August 17, 2011 at 11:43 PM
Thank you!
- December 26, 2011 at 2:23 PM
Thank you so much for the crib instructions!
- February 25, 2012 at 7:20 AM
- johnnybegood1048 said...
I read your blog and I really thank you for caring to share. I looked all over for these instructions after finding out the manufacturer went belly up. one of my sons handed down this crib to his brother but in the move the manual got lost.
Again, thanks, John - April 2, 2012 at 10:23 AM
- Amy Pattisson said...
Do you have the part where it tells you how to convert into a full size bed?
- March 25, 2013 at 7:31 PM
Thank you!
- January 18, 2014 at 11:52 AM
I was sent to your site looking for the Carter's Classic instructions but I do appreciate you taking the time to upload these ones. I'm not sure yet if they'll work so I've booked marked you page to try it out when I get home.
- June 17, 2014 at 10:41 PM
Thanks! :-)
- December 14, 2014 at 5:58 PM


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This briefing is for members of the Nonprofit Roundtable of Greater Washington, DC. HBX Executive Director, Mila Kofman, will share information about the Affordable Care Act and the DC Health Benefit Exchange. She will also discuss how nonprofits can be engaged as stakeholders in the building and implementation of the Exchange.
The following reports are also available:
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What the EU Should Learn From Ireland's Austerity Fiasco
Letter From Limerick
STEPHEN KINSELLA is a lecturer in economics at the University of Limerick.
See more by this authorOn November 2, Michael Noonan, Ireland's minister for finance, stood before the Irish parliament to explain why the government decided to pay back one billion dollars -- funds that Ireland didn't have -- to unsecured bondholders. It was not that he wanted to pay off the debts run up by the now defunct Anglo Irish Bank, Noonan argued, but he had no choice. His predecessor had made an agreement with the European Central Bank and he was bound to honor it.
Just a year earlier, a member of parliament in the opposition had warned against just such an "indefensible" and "obscene" move. "What legal or moral compulsion is there on Ireland to honor in full debt incurred by Irish banks," he asked, "when there was no state involvement in the arrangements? These loans were entered into freely by willing lenders and borrowers . . . The interest rate charged represented the risk at the time and there never was a state liability."
That man was also Michael Noonan. Despite his party's coming to power in the subsequent year on a platform of change, reform, and jobs, by late 2011 he was repaying bondholders in defunct banks, shelving reform of Ireland's institutions, and doing next to nothing to check unemployment. That November day in Ireland's parliament was telling. Noonan spread his hands as if to say, What can I do?
What indeed? Ireland is broke. The value of the country's output is at a virtual standstill (around 160 billion euros), and the IMF projects it to stay that way for the next few years. Meanwhile, unemployment is at 14.5 percent, and roughly half of the unemployed have been jobless for a year or more. Ireland's households are among the most indebted in the world. Several indexes, such as the EU's Survey on Income and Living Conditions, show that the country's poorest are worst affected. Accordingly, suicides, alcohol consumption, and violent crime have all risen since the construction bubble first burst in 2007. Although there have been protests and muted anger over the dinner table, however, there has been no rioting on the scale of that in Greece. All told, the Irish are bearing a considerable burden fairly well.
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Request a Copy of a Report
To request a copy of a report, fill out the required form and mail it to us with the required fee. Requests received without the required fee will not be processed.
You will be required to provide the address of the incident, as well as the date and time it occurred. It is helpful to know what type of report you are requesting. For example if it is regarding a Burglary or Assault. Names of people involved in the incident will also assist us in locating the report.
If a report has been referred to the District Attorney's Office for review of criminal charges, you will not be able to get a copy from Records. In referred cases, you will need to request it directly from the District Attorney. You can reach their office at (541) 474-5200.
Other reports the Records Division cannot release:
- Reports regarding juveniles
- Mental health or medical related incidents
- Medical Examiner's report of death/autopsy
- Toxicology reports


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Record 21 of 27.
The TCL 200 Digital Alarm Clock is a flashing, voice output digital alarm clock with a vibrating signal and amplified alarm, and it is a visual and vibrating telephone signal indicator. It is designed for use by people who are blind, deaf, and hard of hearing or have low vision. This clock has an illuminated digital clock face with a bright flashing LED light on the top that is activated when the alarm sounds. It can announce the time in five languages (English, Spanish, French, German or Italian). The volume of the audible alarm adjusts up to 90 decibels (dB), and there are three alarm settings (loud signal, vibration or both). The clock's alarm can also be set to activate daily, on weekdays only or on weekends only. The clock includes a cordless vibrating pad with an on/off switch that will vibrate when the alarm sounds if the clock is set for vibration. The clock's connection to the vibrating pad is wireless with a range of 300 feet so it can be placed under a mattress or pillow. The clock can be connected to a telephone, and its alarm signal options (visual, audible and tactile) can all be used as a telephone signal indicator and as a ring amplifier. The user can select from five ringtone patterns. Other features include a snooze button with a delay of 0, 5 or 15 minutes; adjustable tone control; battery backup for alarm in case of power outage; the vibrating pad functions for 80 hours on a single charge in the standby mode. POWER: Uses a standard 100-240 volt, 50/60 hertz plug and AC adapter (included) with a backup of two AAA 500 mAh Ni-MH batteries (included); the vibrating pad has a rechargeable battery that charges from a charging cable (included). WARRANTY: Two year warranty.
Notes: Shipping and handling charges are not included in the purchase price.
Price: 124.95.
Link to Video:
This product record was updated on September 27, 2013.
Link to more products from Amplicom USA
Link to more products from Harris Communications Inc.
Link to more products from Hear-More Products
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Sunday, March 10, 2013
DOVER — The AARP will offer the course on April 4 & 5 from 1-5 PM at the Wentworth Douglass Hospital in Dover NH. The course is designed for drivers age 50 and over, but open to all ages. The cost is $12 for AARP members and $14 for nonmembers. Some insurance companies offer discounts for completion of the course. Both days must be attended. Contact James Guyett, Instructor at 603-742-6075. If machine answers leave your name and number to confirm your reservation.
We offer a wide range of fitness classes specifically geared towards Seniors including Chair Yoga, Zumba® Gold, Cardio and a Muscle Strength Range of Motion class. Pick up our newsletter or call (603)516-6436 for information on classes, times and cost for these programs. We are located in the McConnell Center at 61 Locust Street – enter Door # 1 to visit the Center!
The luncheons, which are organized and partially funded by Families First Health and Support Center, include soup, sandwiches, salad and dessert, for $4. The Community Campus, home to several social service agencies, is located at 100 Campus Drive in Portsmouth.
In case the school is closed on the scheduled Tuesday, there will be no meeting of the Good Ole Sports.
The Tea Party is held on the 2nd Wednesday of each month at 1 PM. Join us for tea, coffee, goodies, cards and board games. Bring a friend or two. There is no charge or reservation required.
The indoor Yard Sale will now be held on Saturday April 6. More details to follow.
For more information please call (603)473-8324. |


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Functional Genomics of Cardiopoiesis
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Funding Type:
Basic Biology III
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Public Abstract:
In the United States, heart disease is the number one killer of adult men and women. Another 5 million survive with insufficient cardiac function. The demand by patients with end-stage heart failure exceeds the supply of suitable donor hearts, and so there has been considerable recent interest in cell-based therapies as an alternate means of regenerating injured hearts. There is an obvious medical need for restoration of myocardium. Self-repair is unquestionably insufficient to offset cell death in heart disease, and this has triggered considerable efforts to restore myocardium with cardiac cells from exogenous sources via transplantation, or by stimulating endogenous regeneration. Several reports show some degree of integration of exogenous myocardial cells in animal transplant models, and clinical trials have been performed using a variety of non-cardiac cells. Although some reports cite improvement in cardiac performance, others show equivocal results – improvement clearly requires more research. Thus, understanding how to produce the three main cardiac lineages will be a major advance in directing formation of these cell types for research and eventual clinical applications. Our approach integrates advances in stem cell biology, high-throughput (HT) biology, and informatics to identify key pathways that control heart muscle formation from human embryonic stem cells (hESCs). High throughput assays have been developed and implemented to identify genes, signaling proteins, and micro RNAs that control important steps in the differentiation, proliferation, and maturation of cardiovascular cells. Computer modeling and informatics will be used to identify and validate the pathways that direct these critical processes. The discovery of pathways will lead to protocols for efficient directed differentiation of cardiovascular lineages from hESCs for research into transplantation.
Statement of Benefit to California:
This proposal is a collaboration among stem cell biologists, bioinformaticians to address a critical problem that limits the widespread use of hESC for cardiology applications. Developing the multidisciplinary technology and overcoming the hurdles to application of hESCs to clinic will benefit California in many ways, including: 1. Research to discover novel pathways to stimulate heart muscle regeneration from hESCs is clinically important. Cardiovascular disease is the single largest cause of death in the U.S. and the assays we will develop will be useful tools to direct cardiovascular regeneration. This will speed up the translation of hESCs to the clinic, specifically by stimulating production of cardiomyocytes and potentially by enhancing their integration and function after engraftment. 2. Heart regeneration from hESCs probably uses similar cellular proteins and signaling pathways as regeneration of cardiomyocytes from other sources, thus, this research might be broadly applicable to heart muscle repair. Regeneration from endogenous cells remains insufficient to but these tools should be useful reagents to study and hopefully stimulate endogenous repair. 3. Bringing the people together (stem cell biologists, bioinformaticians) to address a stem cell problem forges new links in the academic community that should be capable of opening new areas of research. These new areas of research will be an important legacy of the stem cell initiative and promises to invigorate academic research. 4. The identified active pathways during cardiovascular differentiation in this proposal are likely to provide promising therapeutical targets, which can spin off new areas of investigation and biotech products with the potential to benefit the practice of medicine and the local economy. 5. Lastly, supporting the leading edge technology such as of high throughput functional using ESCs reinforces California's world leadership over the embryonic stem cell field, which both confers a strategical advantage and prestige from which the entire Californian scientific community and population benefit.
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The tree in Ipswich which could look like Postman Pat
Thursday, March 6, 2014
A tree which could resemble Postman Pat has already won approval from the children's favourite himself.
This picture of the tree, in Christchurch Park, Ipswich, and its gnarly features was sent in by iWitness reporter Val Bond and the first look-a-like suggested was the famous postie.
Pat first acknowledged the resemblance on Twitter, saying: "Can't believe there is a tree that looks like me.
"Even though Cumbria is home, Ipswich now has a special place in my heart."
On the Ipswich Star's website and Facebook page people have been suggesting other doppelgangers for the tree.
The Goonies' unlikely hero Sloth and Homer Simpson both received mentions, as did Sid the Sloth from Ice Age while Dunstan Dowling thought it could be an orc from Lord of the Rings.
But not everyone was entertained by the titillating timber.
Steve Shapland wrote: "It's a tree. Get over it."
Tell us who you think the tree looks like: @ipswichstar24 or facebook.com/ipswichstar24.
1 comment
errr you do know that postman pat isn't real? sorry to break it to you.
Thursday, March 6, 2014


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Miley Cyrus is giving Lil Kim's rap protege Tiffany Foxx a huge publicity boost after filming a cameo appearance in her new music video.
The former Disney star reached out to Foxx on Twitter recently to reveal she was a fan and the pair appears to have hit it off, even exchanging private messages via the social networking website.
Foxx invited her new pal to make an appearance in the promo for her Lil Kim duet Twisted and Cyrus took her up on the offer, showing up on the Hollywood Hills set on Sunday to meet the aspiring star face-to-face, reports AllHipHop.com.
Photos from the video shoot have since surfaced online, with Cyrus, dressed in black and white striped pants, posing for pictures alongside a dolled up Foxx and Kim.
Copyright WENN.com


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This past week has been the hardest I've ever faced and now I'm finally starting to get my act together so I can function. I didn't think life without my Grandpa would be this hard, but I also had nothing to compare it to except for my first companion dog dying.
Watching my Grandpa die was more traumatic for me than I could handle and I guess I'm not as mature as I'd like to think I am? I've been seeing a grief counselor and I think that's helping, but right now I'm still putting everything that happened together.
Last night my Grandpa lost his battle with cancer, and I was alone with him when he went. It was pretty bad actually : (
My family and I want to thank all of you for your kinds words, prayers, and just being there for us. It's great to know that people still care about others.
And Grandpa...thank you for everything : )
Mom got the keys to her new place on Monday morning, which was great timing because I was off school Monday and Tuesday because my school is a polling place for the election. It ended up being two really good days, and having President Obama re-elected made things even better. I just don't think Mitt Romney would have done anything positive for GLBT's.
I'm right on time with my every other week journal entry, but I'm hoping to do better soon. Right now my life's a combination of weird and awesome with a extra helpin' of suck.
My Mom left New York City on one of the last flights to leave before Hurricane Sandy hit, and she arrived at our place late at night, way after I was sound asleep. Once I take my glasses off and turn out the lights I'm out cold.
I woke up the next morning to her turning on my nightstand light and pulling off my blankets to wake me up, and I guess it would have been great except for...
A) I sleep naked
Wow, this is becoming a habit of me writing a journal on here every other week...I need to do something about this!
I've had lots of changes in my life lately, split evenly between good and bad. On the positive end of things my Mom is moving here in November, her studio apartment lease is up and she jumped on a job transfer that happened at just the right time for her. We got a big box of her stuff that she had shipped to us yesterday, sitting in our guest bedroom waiting for her arrival.
In my last journal I wrote about being in a new school and starting over, and for once feeling safe at what my Dad always calls "my job". Now that I've been in school a few weeks I'm starting to open up to people, and actually smiling...
Okay...smiling? What's the big deal with smiling?
For me, especially the last few years, smiling was a rare thing. I was too scared all the time to laugh or smile, fear the invisible shadow that never left me alone.
I've written before about being home schooled and the reasons why, but this year my family decided that I should try going to a regular school again, but the school I go to now is far from regular.
I go to a tech based private school where individual learning is the emphasis along with diversity, two things seriously missing from my old private school. There it was all about helping the children of (illegal?) immigrants become better English interpreters for their parents and creating the future high school football and basketball teams. Does that sound mean? Maybe. Sadly it's the truth.
I saw this online and had to share it!!!
The title of this journal just gave away my secret didn't it?
For a long time I've been debating with myself and my family and friends if I should ever write about this or not, and with everyone except my Mom encouraging me, I felt now was the right time.
I have Asperger's Syndrome, a type of autism.
And honestly, as hard as this may be to believe, I have no idea what that really means. No matter how many times it's been explained to me, I just don't understand it. I've been told that I'm "high functioning" which tells me I'm normal...or am I?
Back in June I wrote about being without the Internet for a while while on vacation and how it gave me time to think...
For the past few days I've been without Internet service and TV because of a line problem where I live, and I again had the time to think about things, especially how much we depend on technology to exist.
I saw this commercial during the Olympics and I just totally love it, he's so much like me!
Thank you Nathan! Keep on running!
I've always been a Adidas guy but now I have a reason to love Nike!
It's been a while since I've posted a journal on here, not because of laziness or anything like that, I've just been busy.
Too busy really!
Puberty has been painful for me, literally, and now I'm at my full adult height and weight just over 200 pounds. I'm actually taller than my Dad now, and have size 11 shoes! My Dad has to stand on his toes to hug me, but that's okay with us.
I saw this commercial while watching the Tour De France and it's so inspiring to me!
Sam : ))
[Part 3 of "To Live Is To Survive"]
Before I started writing here I spent (wasted?) a lot of time in gay chat rooms, sometimes giving my real age, sometimes making myself 18 or whatever I felt like that day. The attention I was given pretending to be an adult was freaky and usually scary, strangers wanting personal info like my phone number, location, and penis size...and other stuff. It got to where I'd just do a intro giving that out (never using a location anywhere near where I live) and the weird questions would happen like magic.


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The City of Arvada and the Arvada Bicycle Advisory
Group Bike Ride Schedule
There are three different categories of rides: a ride for less experienced adult cyclists; a family ride perfect for all ages; and "Fast and Furious" rides for more experienced teenage and adult cyclists.
- Family ride: Family rides are designed for all ages and abilities. These rides move a little slower so less experienced riders and children can get familiar with riding techniques.
Saturday, August 10: This ride is just over 6 miles and runs along the Ralston Creek/Clear Creek trail network. This area offers stunning creek views. The ride will be an out and back with the turnaround point at scenic Lowell Ponds. We will stop at Lowell Ponds for a break and snacks. Please meet in the parking lot on the east side of Memorial Park. - Less experienced adult cyclists: Haven't been on a bike in awhile? Thinking about getting back in the saddle again? These rides are for you. They are designed to build confidence and remind you of the joy of cycling. They will cover 6 miles or less and are primarily on the trail system, with a few low volume streets thrown in.
Saturday, September 14: Meet at Memorial Park, 59th Avenue and Ammons Street in the north parking lot. This ride will be a combination of off-street trails, low volume streets with bike lanes, and very low volume residential streets. The route follows the Ralston Creek Trail to Oak Street, then returns via West 66th Avenue to Independence Street and back to the start via Brooks Drive. - Fast and Furious rides: These rides are tailored for the more experienced cyclist. The rides will be 20+ miles and will include both street and trail riding. Riders must be experienced in riding with traffic on busier roads. These rides will take place on the same dates as the other rides. Courses will be announced soon. Stay tuned to Arvada.org and the Bicycle Advisory Group Facebook Page.
All rides begin at 9:00 a.m. All riders must sign a release. Helmets are required.
For further details, watch Arvada.org and the Arvada Bicycle Advisory Group Facebook page: facebook.com/ArvadaBikeAdvisoryComm/events.
Would you like to join the Arvada Bicycle Advisory Group? Do you have any questions? Contact Anne Tully firstname.lastname@example.com


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