text:
From Wikipedia, the free encyclopedia - View original article
Theory X and Theory Y are theories of human motivation created and developed by Douglas McGregor at the MIT Sloan School of Management in the 1960s that have been used in human resource management, organizational behavior, organizational communication and organizational development. They describe two contrasting models of workforce motivation.
Theory X and Theory Y have to do with the perceptions managers hold on their employees, not the way they generally behave. It is attitude not attributes.
In this theory, management assumes employees are inherently lazy and will avoid work if they can and that they inherently dislike work. As a result of this, management believes that workers need to be closely supervised and comprehensive systems of controls developed. A hierarchical structure is needed with narrow span of control at each and every level. According to this theory, employees will show little ambition without an enticing incentive program and will avoid responsibility whenever they can. According to Dr Kumi Mark, if the organizational goals are to be met, Theory X managers rely heavily on threat and coercion to gain their employees' compliance. Beliefs of this theory lead to mistrust, highly restrictive supervision, and a punitive atmosphere. The Theory X manager tends to believe that everything must end in blaming someone. He or she thinks all prospective employees are only out for themselves. Usually these managers feel the sole purpose of the employee's interest in the job is money. They will blame the person first in most situations, without questioning whether it may be the system, policy, or lack of training that deserves the blame. A Theory X manager believes that his or her employees do not really want to work, that they would rather avoid responsibility and that it is the manager's job to structure the work and energize the employee. One major flaw of this management style is it is much more likely to cause diseconomies of scale in large picture.
In this theory, management assumes employees may be ambitious and self-motivated and exercise self-control. It is believed that employees enjoy their mental and physical work duties. According to them work is as natural as play. They possess the ability for creative problem solving, but their talents are underused in most organizations. Given the proper conditions, Theory Y managers believe that employees will learn to seek out and accept responsibility and to exercise self-control and self-direction in accomplishing objectives to which they are committed. A Theory Y manager believes that, given the right conditions, most people will want to do well at work. They believe that the satisfaction of doing a good job is a strong motivation. Many people interpret Theory Y as a positive set of beliefs about workers. A close reading of The Human Side of Enterprise reveals that McGregor simply argues for managers to be opened to a more positive view of workers and the possibilities that this creates. He thinks that Theory Y managers are more likely than Theory X managers to develop the climate of trust with employees that is required for employee development. It's employee development that is a crucial aspect of any organization. This would include managers communicating openly with subordinates, minimizing the difference between superior-subordinate relationships, creating a comfortable environment in which subordinates can develop and use their abilities. This environment would include sharing of decision making so that subordinates have a say in decisions that influence them.
For McGregor, Theory X and Y are not different ends of the same continuum. Rather they are two different continua in themselves.
McGregor had identified Theory X and Theory Y differently for the basic characteristics stated previously in the above sections of what these theories represent. Theory X assumptions are that individuals dislike their careers. Theory X people have to be supervised. As for Theory Y assumptions are that individuals like their careers and are willing to take part in responsibility. Theory Y people don't need supervision and can be expected to turn good productive value in their jobs.
Based on employees we take a closer look at the relationship between supervisors and "subordinates," as some may call them, or workers.[1] The quality of the relationship between the two can be described by Sahin as a term called leader-member exchange (LMX) theory. What LMX theory basically points out against McGregor theory is that "leaders develop unique relationships with different subordinates and that the quality of these relationships is a determinant of how each subordinate will be treated".[2]
With these two theories combined Sahin individual and the organization at the same time. In addition, workers (subordinates) develop feelings of affective commitment if they receive the importance from supervisors not just by overlooking them all the time but by also giving them importance.[3] In addition look at external link for image, that explains the function of the theory.
McGregor identified people based on two theories they can possibly have, Theory X, or Theory Y. But Sahin shows a different approach through his study of the LMX theory. He shows how different styles used upon by management can vary from both theories.
Theory X and Theory Y relate to Maslow's hierarchy of needs in how human behavior and motivation are main priorities in the workplace in order to maximize output. In relation to Theory Y, the organization is trying to create the most symbiotic relationship between the managers and workers, which relates to Maslow's needs for self-actualization and Esteem. For self-actualization, the manager promotes the optimum workplace through morality, creativity, spontaneity, problem solving, lack (or minimization) of the effects of prejudice, and acceptance of facts. We must accept that prejudice exists in others, even as we try to minimize it in ourselves. These issues relate to Esteem when the manager is trying to promote each team member's self-esteem, confidence, achievement,happiness, respect of others, and respect by others.
Douglas 2013


text:
Álvaro Vargas Llosa on Immigration and Globalization Recorded: Tuesday, November 19, 2013
International political commentator and Independent Institute Fellow, Álvaro Vargas Llosa, discussed his book Global Crossings at the Dole Institute of Politics.
Experts: Alvaro Vargas LlosaType: TelevisionIssues: Culture/ Society, Economic History and Development (International), Economic History and Development (U.S.), Economic Policy, Immigration, Latin America, Political Ideology and Philosophy
Maura McEnaney on Willard Garvey at Wichita Rotary Club Recorded: Monday, October 28, 2013
Maura McEnaney, author of Willard Garvey: An Epic Life, speaks before the Rotary Club of Wichita on October 28, 2013, about her new book published by The Independent Institute's LibertyTree Press.
Experts: Maura McEnaneyType: TelevisionIssues: Business, Culture/ Society, Economic Policy, Entertainment, Family, Government Waste/Pork, Housing, Privatization, Trade
John C. Goodman at P.A.U.L. Festival 2012 Recorded: Friday, August 24, 2012
Independent Institute Research Fellow John C. Goodman addresses P.A.U.L. Festival 2012 on The Free-Market Alternative to Obamacare.
Type: TelevisionIssues: Bureaucracy and Government, Economic Policy, Free Market Economics, Government Waste/Pork, Health Care, Politics, Privatization, Public Health/ Consumer Protection, Regulation and Deregulation, Taxes
Alexander Tabarrok on Bounty Hunting & Defending the Indefensible Recorded: Thursday, August 18, 2011
Alexander Tabarrok, Research Director at the Independent Institute, speaks with John Stossel of Fox Business Networks Stossel on bounty hunting and defending the indefensible.
Experts: Alexander T. TabarrokType: TelevisionIssues: Crime, Criminal Justice/ Prisons, Law Enforcement, Privatization
Alvaro Vargas Llosa on Honduras, Zelaya Recorded: Tuesday, June 30, 2009
Originally aired on TNRtv on 6/30/09. Alvaro Vargas Llosa discusses Zelaya and Chavez, as well as changes in Argentine leadership.
Experts: Alvaro Vargas LlosaType: TelevisionIssues: Democracy, Latin America
Alvaro Vargas Llosa on the Latin American Left Recorded: Friday, April 29, 2005
Senior Fellow Alvaro Vargas Llosa discusses the rise of the Latin America left on the NewsHour with Jim Lehrer on PBS.
Experts: Alvaro Vargas LlosaType: TelevisionIssues: Economic History and Development (International), Latin America

subset: commoncrawl


text:
New Red Soft Crocodile Fume Zip Around Wallet
Made of precious crocodile and lined with nappa leather, this luxurious wallet is the result of meticulous craftsmanship. This shiny crocodile wallet is not only beautiful, it is also an investment in lasting style. The wallet has a zip-around closure for security and plenty of room for cards, coins, and bills.
- Solid color, Zip closure, Leather lining, Internal zip pocket, Internal card slots
Composition: Crocodile leather, Lambskin, Brass
Depth: 2,5 cm
Height: 10,5 cm
Width: 19,5 cm
Style: 114076V90236574
Select color
Select size (Size Guide)
- OneSize


text:
everyday napkins | ochre collection | limited run
we believe that food tastes better and is more appreciated when accompanied by a cloth napkin! (not to mention creates less waste!)
these napkins come 6 per set and are a smaller everyday size, 11"x11". label appears only on the first napkin. 100% linen.
these vibrant ochre trimmed everyday's are a sophisticated addition to your spring + summer table.
originally $50
a very limited run.


text:
The "Natural Wave" is a ceramic plate that sits on a steam radiator, making it easy to keep drinks and muffins warm. And only muffins! It's not rated for bagels or toast by the National Ornamental Snack and Hotcakes Administration (NOSHA).
It's also not real, or at least not available for purchase. It's just a concept by Byung-seok You, but something similar should be easy enough to cook up for yourself should you live in an old building that still has radiators. (Unlike my building which has modern heat that is never actually on.)
Radiators Have Other Uses Too [YankoDesign.com]


text:
this wiki
The .45 ACP (.45 Auto) is a large caliber rimless centerfire pistol cartridge. It has been in service since before World War I, and saw popularity when it was utilized in the Thompson SMG. Although it is not as long or as powerful as the .44 Magnum cartridge (due to the fact that magnum cartridges use more propellant and fire at higher pressures), it is slightly larger in diameter. The .45 ACP is one of the most popular pistol cartridges in production today, having had countless firearms chambered for it over its lifetime.
The .45 Automatic Colt Pistol (ACP) cartridge was developed for the Browning designed Colt Model 1905 automatic pistol, which was a development of the earlier Model 1903 pistol, in .32 caliber.
Since the Thompson-LaGuard Board of 1904 recommended the nothing smaller than .45 caliber be considered for the new service automatic, this cartridge was adopted as the new service pistol round.
Original military specifications for the Cartridge, Ball, Caliber .45, M1911 as adopted by the Ordnance Department were a 230gr FMJ roundnose lead-cored bullet, with jacket of copper, copper-washed mild steel, gilding metal, or cupronickel, loaded over a charge of 5.0gr Hercules Powder Company "Bullseye" propellant. This combination was specified to produce 825–850 feet per second from the muzzle of a 5" barreled M1911 service pistol. This duplicates the ballistics of the blackpowder .45 S&W Schofield cartridge that it replaced in service.
Design detailsEdit
The .45 ACP is a rimless, straight-walled cartridge, and uses a large pistol primer. It has a case capacity of 25 grains. The bullet is .452 inches in diameter, and range in weight from 155 grain to 230 grain[1], though 250 grain is not unheard of in some lead cast loads. .45 ACP is fired optimally through a barrel with a 1/16 twist, and fires with a maximum pressure of 21,000 psi, producing a muzzle velocity of 825-850 feet per second.
Being one of the most popular cartridges in use, .45 ACP comes in many forms. FMJ and JHP is most prevalent, and cartridges sold for self-defense purposes may be loaded to +P pressures.


text:
Deadly Storms Hit Southeast
At least two people are dead after overnight tornadoes in Alabama.
Powerful storms swept across four southern states overnight, spawning tornados that killed at least two and injured more than a hundred others.
Residents in Arkansas, Tennessee, Mississippi and Alabama all raced for cover as the storm system destroyed homes, downed trees and left behind a path of destruction.
Sandra and Levern Green of Dallas County, Arkansas had just seconds to take shelter in their bathroom.
"It was over in about five minutes, and we could feel wind blowing on us and we looked and the bathroom ceiling was all mashed in with a limb in it," Sandra said afterward.
Despite the devastation residents remain strong.
"We're tough down here," said Tony Hanes. "We'll recover...everybody will pitch in and we'll be back on top."


text:
After Dean reportedly cheated on Tori in Toronto on Dec. 6, she is doing everything in her power to stop him from stepping out on her again — including monitoring all of his incoming calls and texts! Do you think Tori is going too far or she right to distrust Dean?
Tori Spelling has been standing by her husband, Dean McDermott, despite reports that he cheated on her — but that doesn't mean she's ready to trust him again. In fact, Tori is so worried that Dean will have another affair that she's asked him to hand over his cell phone to her for safekeeping, a new report says.
Tori Spelling On Dean McDermott 'Affair' — She's Checking His Phone
Dean, who is still living in the couple's Encino, Calif. home, surrendered his phone to Tori in an effort to make up for his alleged indiscretion. Unfortunately Tori's Big Brothering hasn't solved all of their problems. "They are fighting like cats and dogs," a source tells Us Weekly. "Tori has been tearing into Dean about how embarrassing this all is."
Despite the serious strain on their marriage, Tori ultimately may not divorce Dean. She'll do anything to avoid "ripping her family apart," says one source.
It's no wonder she wants to think this through — Tori and Dean have four beautiful young children together: Finn, 16 months, Hattie, 2, Liam, 6, and Stella, 5.
"It's been a lot to take in. She's trying to decide what's best," another source tells the mag. Unfortunately the divorce may not be Tori's decision to make, according to one report.
Dean McDermott 'Wants To Divorce' Tori Spelling — Report
Shockingly, Dean might be the one to pull the plug on their marriage.
"Dean wants a divorce and has for some time, but Tori is holding on for the sake of her business and her public image," a friend of the couple's told Star magazine. "Her heart is breaking, and she is at a loss for what to do."
HollywoodLifers, do YOU think it's right for Tori to monitor Dean's phone? Have you ever checked a significant other's phone for signs of cheating? Let us know in the comments.
– Tierney McAfee
More Tori Spelling & Dean McDermott News:
- Tori Spelling & Dean McDermott Living 'Separate Lives'
- Tori Spelling Refusing To Confide In Mom Over Dean McDermott Troubles
- Tori Spelling & Dean McDermott Do Not Have A Prenup — Report
View Comment
Posted at 1:41 AM on April 20, 2014
Posted at 10:17 AM on January 22, 2014
Having a bunch of kids won't tie a man down…..get it Tori? That never works! Just in case, don't go having another baby to work things out. The kids will suffer. Once a cheater, always a cheater. She should have seen that as a major red flag before she married him.
And payback is just what it is!
Posted at 7:27 PM on January 11, 2014
Tori Spelling cannot force Dean McDermott to do anything he does not want to do. Tori needs to acknowledge the fact that her husband has rejected her for another woman the same way he rejected his ex wife for Tori Spelling. Tori should spend her time and money with an attorney and professional counselor if she wants to successfully get through this.
Posted at 11:25 AM on January 10, 2014
Posted at 11:25 AM on January 10, 2014
Start working at home with GOOGLE!YAHOO. ABCNEWS AND MORE GLOBAL SITES… It's by-far the best job I've had. Last Wednesday I got a brand new BMW since getting a check for $6474 this – 4 weeks past. I began this 8-months ago and immediately was bringing home at least $77 per hour. I work through this link, ….. WWW.MAX47.COM
Posted at 12:10 AM on January 10, 2014
I am sorry she knew he was like this when they met dean was married with a kid and I believe she was married or in a very serious relationship they both were in an affair did she worry then she was breaking up a marriage nope. So now she is getting a BIG taste of her own medicine! I only feel for those children going through all this drama.
Posted at 11:41 PM on January 9, 2014
Posted at 12:00 PM on January 10, 2014
Posted at 9:33 PM on January 9, 2014
Posted at 9:13 PM on January 9, 2014
Posted at 7:54 PM on January 9, 2014
If she's checking his phone, that means she doesn't trust him.
The relationship is already over.
If you don't have trust in the marriage, what do you have?
When the trust is gone, it's time to go your separate ways, unless you both are willing to put in a lot of work to fix what is broken.
I think they had too many kids too quickly.
Hopefully he didn't really cheat and they can work on the relationship and parenting the kids.
They also are having money problems and now have to budget like regular people.
That has got to hard for Tori who was born with a silver spoon in her mouth.
When her dad died and her mother cut her off, that had to hurt.
I hate to see families split up.
Hope they can work it out.
just before I saw the draft that said $8045, I have faith …that…my father in law woz like realy earning money part-time from there pretty old laptop.. there sisters neighbour has done this for less than 16 months and as of now took care of the loans on there mini mansion and bought themselves a Land Rover Range Rover. pop over here
Try it >>>>>>>>>>>>>> JUMP26.ℭOℳ


text:
I am very happy that an organization as UNESCO is stepping forward to create a special event for celebrating our cultures and make us look inside to who we are and what are we doing as we co-habitate this planet.
Description: The Children in a circle represent a harmonious celebration of their cultures and lives. The different colors of the children symbolizes the myriad of cultures in our planet. The festival feel is also connotated with the cursive type in different colors. The cursive type has a more dynamic feel that goes with the tone of the festival. The harmonious feel of the girls playing is the ideal celebration of the diversity of cultures. But to achieve this harmony people have to work and engage with people and its cultures. You have to be curious why people speak different languages or dialects. You might want to taste different types of food that different cultures offer and discover amazing tastes from different corners of our planet. They might clue you in an organic cloth water repellent material that you've never seen because there is a certain plant that only grows under certain conditions. Or a type of wood that is very flexible and resistant that you could use for your house. This is the type of energy it is stored in the myriad of cultures that we have to discover and engage with them. Its a process of discoveries that is going to transform our planet and unleash a tsunami of energy that will carry mankind to galaxies that we never thought we could visit. When we learn and appreciate other cultures in our planet we realize how valuable your own culture is and appreciate your individuality, and your essence of being. We develop a sense of respect for mankind and its different ideas that have to be learned and accepted. This is a very demanding process because you might encounter cruelty within cultures and you have to make choices and sometimes you can not change cultures. But this energy you experience will start to open up a sense of wonder and beauty of our planet our Children will like to experience as they start their journey through life.


text:
24 Quick and Easy Knitting Patterns
Bonus: Get our newsletter & special offers for free. We will not share or sell your email address. View our Privacy Policy
Diver Down Flower
By: Maria Nerius
Use your knitting loom to make this pretty diver down flower, an essential part of safe scuba diving. This free knitting pattern is from craft designer Maria Nerius.
- Red Premier Yarn
- Clover Hana Ami Flower Loom
- Large eye needle
- Scissors
- Small sand dollars
- White or fabric glue
- Make the flower following the loom instructions. You can vary the thickness of your flower by adjusting the amount of yarn you use.
- Glue sand dollar to the side of flower where you can see the finishing knot. This way your flower look pretty front and back.
- Using ribbon, make a hanger and knot off. Trim.
Tags / Related Topics
Your Recently Viewed Projects
Love these projects? Get MORE delivered to your Inbox – FREE Click Here!
Something worth saving?
- SAVE all your favorite crafts
- ADD personal notes
- QUICKLY reference your crafts
Free eBooks
- 12 Thrifty Trash to Treasure Crafts
- 17 Flower Craft Ideas: How To Make Paper Flowers, Easy Fabric Flowers and More
- 18 Crafts with Felt: Simple Craft Ideas, Felt Flowers & More
- 24 Tie-Dye Techniques: Free Tie-Dye Patterns
- 24 Valentine's Day Crafts for Kids: Lovely Kids Crafts Ideas and Projects
- 25 Cool Things to Do with Wine Bottles
- 26 Spring Crafts for Kids
- 41 Valentine's Day Crafts: Valentine's Day Cards, Gifts and More
- Cupid's Handmade Crafts
- Irish for a Day: St. Patrick's Day Craft and Recipe Guide
Our Newest Projects & Articles
- Learn to Embroider with the Best of Leisure Arts
- Colorful Ladybugs Toilet Paper Roll Craft
- Reworked Rainbow Table DIY Craft Project
- Leisure Arts Book Bundle
- Polyform Sculpey Clay Beginner Pack
- Red Heart Fancy Yarn Pack
- 13 Spring Crafts: Easter Craft Ideas, Spring DIY Home Decor, and More free eBook
- American Quilter's Society Gift Card
- Marvy Uchida Easy Crystal Applicator
- Sizzix eclips2 DIY Electric Cutter Starter Kit


text:
Rancilio Espresso Machine Brew Head Shower Screen
Does the screen come with the screw that fastens it? The one in my machine is slightly stripped from cleaning the screen over a few years, and I would want to be sure to get the proper hardware (screw) with the new screen. Thanks, Patrice


text:
100 rooms walkthrough help you to solve this amazing puzzle game, from the developer of 100 door which very exciting now MPI developed a new idea of brain teasers game. is not easy to complete 100 doors you must try tap at all catchy object to get a clue, with this 100 rooms walkthrough i will guide you to complete 100 rooms in all level.
100 Rooms Walkthrough Level 1
- tap on the flower vase in the window. Tap again to move it and get the door's lock
- tap on the desk. tap middle drawer and get the handle.
- double tap handle then combine with the lock to make 1 item
- go to door, use the handle to open.
100 Rooms Walkthrough Level 2
- Tap twice on the window & get the handle on the drapes
- Take the small wooden handle from the bottom shelf.
- On the flower pick up a saw.
- Tap twice handle then tap the saw, now tap the wooden then tap the hand saw. Use it to cut lock on the door.
100 Rooms Walkthrough Level 3
- at the window pick a knife
- tap on the trash can pick the brown carton. Use knife to open carton
- tap the chair it move to the middle.
- Use neon put above the chair it will show a number 783461
- Use this number to open the door lock code
100 Rooms Walkthrough Level 4
- tap axe above the door.
- tap power plug near window.
- attach plug to the socket.
- tap the hot water – code will show at the mirror (514796)
- use axe to remove wood on the wall. use code to open safe deposit box pick keys
- use key to open doors.
100 Rooms Walkthrough Level 5
- see code on the painting 2045
- open the window.tap the duck 2 yellow, 4 green, 5 if correct box will appear tap box and pick hammer
- use the hammer on the glass table. tap the piece of glass.
- use the piece of glass on the painting.
- at the door and tap the N letter above. Then tap left once, right three times and left twice.
100 Rooms Walkthrough Level 6
- tap bucket, zoom out then tap on right pipes. Use water to fill the pipe to makes key up then tap key.
- tap plank with code (41423)
- zoom in on the bookshelf, tap book on the circle
- open drawers in front of bookshelf tap BABCD see picture above.
- Go to the painting. Put the teddy bear in the painting and use the key to open, pick the key inside and use it to open door.
100 Rooms Walkthrough Level 7
- tap safe deposit box on the table use the code 981471 pick up the pliers
- in the bookshelf, zoom in it and use pliers to cut the wire. then use the pliers to make wire like a hook.
- on the mail box use the hook to pick a key inside mail box then use it open door.
that's 100 rooms walkthrough for now if you want to get update level 8, 9, 10, 11 ,12 please bookmark levelstuck.com
People looking for:
- 100 rooms escape walkthrough
- 100 rooms escape windows phone
- 100 rooms walkthrough
- 100 rooms
- walkthrough for 100 rooms
- 100 rooms escape windows phone walkthrough
- 100 rooms help
- 100 rooms 6
- 100 rooms level1
- 100 locks level 6


text:
An audio filtering effect for Ableton Live built in Max for Live. It emulates the behaviour of the filter in Ableton's Sampler Instrument and extends it, allowing you to morph between five independent filters each with its own filter type, cutoff, resonance or q and gain.
Download: M4L Morph Filter v5


text:
From Wikipedia, the free encyclopedia - View original article
Alport syndrome | |
Classification and external resources | |
Hearing loss effect of Alport syndrome in 13-year-old boy. | |
DiseasesDB | 454 |
MedlinePlus | 000504 |
eMedicine | med/110 |
Patient UK | Alport syndrome |
MeSH | D009394 |
GeneReviews |
Alport syndrome | |
Classification and external resources | |
Hearing loss effect of Alport syndrome in 13-year-old boy. | |
DiseasesDB | 454 |
MedlinePlus | 000504 |
eMedicine | med/110 |
Patient UK | Alport syndrome |
MeSH | D009394 |
GeneReviews |
Alport syndrome or hereditary nephritis is a genetic disorder[1] characterized by glomerulonephritis, end-stage kidney disease, and hearing loss.[2] Alport syndrome can also affect the eyes causing eye abnormalities including cataracts, lenticonus, kerataconus, as well as retinal flecks in the macula and mid periphery. Visibly bloody urine and protein in the urine are common features of this condition.
The disorder was first identified in a British family by University of Edinburgh Medical School graduate Cecil A. Alport in 1927,[3][4] though William Howship Dickinson is considered by some to have made contributions to the characterization.[5]
Alport syndrome is caused by mutations in COL4A3, COL4A4, and COL4A5, all genes involved in collagen biosynthesis. Mutations in any of these genes prevent the proper production or assembly of the type IV collagen network, which is an important structural component of basement membranes in the kidney, inner ear, and eye. Basement membranes are thin, sheet-like structures that separate and support cells in many tissues. When mutations prevent the formation of type IV collagen fibers, the basement membranes of the kidneys are not able to filter waste products from the blood and create urine normally, allowing blood and protein into the urine.
The abnormalities of type IV collagen in kidney basement membranes cause gradual scarring of the kidneys, eventually leading to kidney failure in many people with the disease. Progression of the disease leads to basement membrane thickening and gives a "basket-weave" appearance from splitting of the glomerular basement membrane, specifically the lamina densa layer. Single molecule computational studies of type IV collagen molecules have shown changes in the structure and nanomechanical behavior of mutated molecules. Notably these lead to a bent molecular shape with kinks in the protein at the site of the mutations.[6]
Alport syndrome can have different inheritance patterns that are dependent on the genetic mutation.
At least four of the following ten criteria must be met to diagnose an individual with Alport syndrome:[12]
The use of eye examinations for screening has been proposed.[13]
A review of pathogenic mutations detected in X-linked Alport syndrome patients in 2011, recommended COL4A5 analysis in any patient meeting at least two clinical diagnostic criteria and that COL4A3 and COL4A4 analysis should be considered if a COL4A5 mutation is not detected and primarily if autosomal inheritance is suspected.[14]
Clinical utility gene card for: Alport syndrome.[15]
Immunohistochemical (IHC) evidence of the X-linked form Alport syndrome may be obtained from biopsies of either the skin or the renal glomerulus. In this processes, antibodies are used to detect the presence or absence of the alpha3, alpha4, and alpha5 chains of collagen type 4.
All three of these alpha chains are present in the glomerular basement membrane of normal individuals. In individuals expressing the X-linked form of Alport's syndrome, however, the presence of the dysfunctional alpha5 chain causes the assembly of the entire collagen 4 complex to fail, and none of these three chains will be detectable in either the glomerular or the renal tubular basement membrane.[16]
Of these three alpha chains, only alpha5 is normally expressed in the skin,[citation needed] so the hallmark of X-linked Alport syndrome on a skin biopsy is the absence of alpha5 staining.[16]
As there is no known cure for the condition, treatments are symptomatic. Patients are advised on how to manage the complications of kidney failure and the spilling of protein in the urine that develops is often treated with ACE inhibitors.[17]
Once kidney failure has developed, patients are given dialysis or can benefit from a kidney transplant, although this can cause problems. The body may reject the new kidney as it contains normal type IV collagen, which may be recognized as foreign by the immune system.[18]
Gene therapy as a possible treatment option has been discussed.[19]
ARUP COL4A5 gene variant database
LOVD Alport gene variant databases (COL4A5, COL4A3, COL4A4)
This article incorporates public domain text from The U.S. National Library of Medicine


text:
We're always hot on the trail of the world leaders when it comes to visual effects. However, as much as we can rant and rave about present and future releases, it's often worthwhile to be reminded of memories from the past, to gain some perspective, and appreciate exactly how far we've come…
Happy 10th Birthday V-Ray!
Some of you may, or may not, know that V-ray is currently celebrating it's 10 year anniversary. So, to mark the occasion, what could they be doing? Are they throwing a week long wild party? A massive shopping spree for all employees? Or maybe a month's extra holiday time to all...
The Joy of Stop Motion Animation - Behind the Scenes Special
Working in the CG industry, I have always been fascinated with stop motion animation. Growing up watching films like Tim Burton's 'Nightmare Before Christmas', I have always wondered what goes on behind the scenes and how it all works. And, funnily enough, a couple of months ago, the flat where I live actually turned into an animation studio overnight.
Ben Cantor Tips
There is a lot of nonsense out there on the internet, and often the line between fact and fiction is a blurred one. For the VFX industry however, the net provides a sturdy back catalogue of fact based webinars, tutorials and breakdowns, with many of the key players in the business regularly exhibiting online what they do. The internet is truly a tool that when utilised, can inspire and educate.
Wreck-It Ralph
I think it's safe to say that most of you now know I love a bit of Disney. So, whenever I hear news of new releases, you get to hear about them. Therefore, I would like to bring to your attention the trailer for Disney's new release; Wreck-it Ralph.
Do you only have eyes for NUKE?
A few months ago our very own Simon Richardson, Escape's in-house 2D genius, posted a series of blogs declaring his undying love for NUKE.
11 Days And Counting
The suspense and build up to The Dark Knight Rises is literally killing us at Escape, we are so excited for the release date it's almost agony how slow time seems to be going. It also doesn't make it any easier that new footage, trailers and behind the scene sneak peeks keep being released!
From Past To Present
It's always interesting to see how different studios rank, whether it's in regards to gaming, films or television. On Wednesday, Develop Online released its top 100 best studios, which, let's be honest is always good to have a nose at. This time, however, what made it more interesting for us is the fact that two escapees have gone on to work for the number one voted UK game's developer, Traveller's Tales!
Scene Stealers
Film4's innovative new project 'Scene Stealers', is one that waters the seed of creative license, and thus, one that is screaming out to our free thinking, boundary smashing escapees. The project is an opportunity to get your work onto a global platform and represent the world of Visual Effects.
Super Trooper
Don't you just hate it when you watch a couple get together that you've been rooting for throughout the movie and then a giant mutant bug stabs her in the stomach and it's all over? Yeah we hate it too. If you're um-ing and ah-ing where this scene-setting image is from then it was, of course, the original Starship Troopers film, released in 1997.
Now Announced... Speakers For HUG London!
Less than one week to go before the UK's first HIERO user group, HUG London and we have kept you waiting long enough as to who will be speaking.
Success Story: Mark Pascoe
Success stories about our escapees are always a pleasure to write up. What's even better though is the opportunity to write another, on the same person, just a year later! Mark Pascoe recently answered some questions for us, explaining his journey from studying Sports Science at University to working on the VFX for an Emmy nominated TV Show for the Discovery channel.
Success Story: Allyn Lawson
It's fair to say that the world of VFX is a bit like a tardis, a tardis that escapee Allyn Lawson knows all about.
The Alenka Abraham Success Story
We've been catching up with lots of the escapees from over the years, and one story in particular has been hugely inspiring to us. Having studied a ten week Maya comprehensive course at Escape Studios back in 2003, Alenka Abraham has paved a very exciting career for herself. Taking on an R&D software project at Glassworks, Alenka met her future business partner, Adam Cubitt. Together they set up Existential Ltd., a company that develops both real-time and off-line computer visualisation and animation technology. Collaborating with leading post-production companies like MPC, and many others across the UK, they've been involved in pioneering projects and are making quite a name for themselves.
Carmine Agnone: Success Story
Carmine Agnone, a lifelong Tim Burton fan and escapee, finished his course with us in April 2011 to work on shots for Burtons new film Dark Shadows only months later - a real dream come true! Since then, he's worked on many projects and built extensively on his wealth of career knowledge.
Escape Studios Graduation Day
Today is a very exciting day for a lot of people here at Escape Studios. Yes, today marks the end of course for a few of our classes (Visual Effects Production and Visual Effects Animation Professional). And to celebrate this graduation day, we thought we'd give a little preview of what we do as a Bon Voyage for our escapees.
Bad Hair Day?
If we are watching a live action film with actors, it's very rare that one of the main character features we concentrate on is the hair. Occasionally a judgemental comment of whether it looks good or not is thrown out there but that's the extent of it. The average viewer will fail to notice if the colour looks wrong in one of the scenes or that it doesn't look realistic enough.
Next Generation Of Sony Entertainment
Huge news was announced this morning that SCE (or Sony Computer Entertainment to those of you not familiar with the Sony department responsible for all things Playstation and games) has purchased the online gaming streaming company GaiKai for $380 million.
Can You 'Recall' The Original?
Yes, I really went there. A new trailer has been released for the updated version of Total Recall, and gone are the days of Arnie showing his rippling torso and basking in the limelight. This adaptation follows Doug Quaid (Colin Farrell) on his quest to find something better than his current life. After discovering 'Rekall', and being warned against it, he decides to rebel (against the norm, funnily enough) and visit the place regardless. This results in Doug Quaid having to question everything to try discover what is, and isn't, real. The film boasts robots, a futuristic (yet dark) London and a whole lot of CG from MPC, Double Negative and Prime Focus. So from an industry point of view, it's definitely going to be worth a watch.
Studio Secrets Come Out From The Shadows
During it's opening weekend, Dark Shadows topped just over $29million at the Box Office. This may not be up to the usual par of some of Johnny Depp's films but the CG within the film didn't fail to impress once again.


text:
MUSIC NERDIST: Best Birfffday Songs, according to me (the guy that's always right.)
By Jonah Ray on August 1, 2008
My birthday is coming up this weekend. I'll be turning an age that's
closer to the signifying number of years you live before you have to
realize yer not a kid anymore. Seeing as how I now cower at the idea of
having any kind of party to "celebrate" my slow death. I have the
feeling that I'll just want to spend it the way I spent ALL of my
formative birthdays, alone and disappointed whilst listening to MUSIC
in my room. So here is a list of some of my favorite BIRTHDAY SONGS:
#5: The original happy birthday song by the HILL sisters in the
late 1800's. It's totally overused and not cool at all. EPIC FAIL HILL
#4: Happy Birthday by CLEM SNIDE. So soothing and happy
sounding, you'll forget that yer decaying body is starting to hurt this
year more than last year.
#3: You say its your birthday! by THE BEATLES. Not their best work
(obviously, a**hole) but mentioned because of it's association with the
movie 16 candles (the scene with Ted in the car).
Lisa It's your birthday, Happy birthday Lisa: by MICHAEL JACKSON (leon
kompowski)…that song will get stuck in your head as easily as gum in
Lisa's Hair. (reference!)
#1: HAPPY BIRTHDAY by WEIRD AL YANKOVIC: I used to play it loudly for
each of my family members on their birthdays. Because i loved it and
they thought it was irritating…EFF THEM. It's one of the punkiest
songs Al ever did. and it was on his ST release. And yes, I still like him.
alrighty, happy birthday to me.
happy birthday!!!!(sorry if the wierd anime moe chibi girl attitude bugs you)
It's my birthday this weekend, too! A happy birthday to the both of us!
I have to agree with your number 2 — that song great, but it drills into your head like the Cerebral Bore from Turok 2.
My birthday dedication to you is the poppy new-wave hit, Happy Birthday, by Altered Images. It smells of cotton candy and has all the lasting influence of dandelion fluff.
Fuckin a! I have Weird Al's first album on cassette. It's STILL a great listen.
I'll drink a few to you tonight
Happy birthday!
Mine's not for another 13 days.
My personal favorite birthday song would have to be "Birthday Dethday" by Dethklok.
Brutal. -
No Happy Birthday by Altered Images?
Happy happy birthday in a hot bath!
Happy Birthday!!!Have a good one!
the podcast electronic music is great! Who is it and how can I buy it. Yes, I said buy. It's that good! Thanks!


text:
Sunset Restaurant
Opening Hours
Breakfast: Monday 6.30am - 10.00am, Tuesdays-Sunday 6.30am - 10.30am
Lunch: Daily from 11.30am-3pm
Dinner: Sunday-Thursday 5.30pm-10pm, Friday and Saturday 5.30pm-11pm
+61 8 8943 8940
Ocean View Buffet
This famous ocean view buffet is located in the heart of our venue, overlooking the magnificent infinity pool and Darwin's breathtaking sunsets.
Sunset's great value all-you-can-eat buffet is a popular choice all year round and is famous for quality choices and reliable service.
True to its name, the restaurant's floor to ceiling windows showcase sunset views that can be enjoyed in air-conditioned comfort or al fresco on the balcony overlooking Mindil Beach.
SKYCITY supports the responsible service of alcohol.


text:
Marine & Outdoor Clothing provide a fantastic range of sailing clothing from top brands Gill, Helly Hansen and Under Armour. Whether you're looking for sailing jackets, sailing base layer or sailing accessories, we have it all in our online store. Free UK delivery is available on all orders, so you can focus on filling your online basket with more for less. Browse our full collection of sailing clothing and buy online today.
Products in the Sailing Clothing category have been rated stars based on 191 reviews |


text:
Novalera is a specialty provider of Website, E-Commerce, and IT Solutions for small businesses and firms within the northern Maryland area. We work closely with our clients to understand their business needs and give them the tools they need to succeed.
Novalera. You focus on success. We'll handle the rest.
Novalera offers services to a wide variety of sites. From simple service or blog sites to full online shopping sites, Novalera can help you get your business online today.
Taking advantage of Website and E-Commerce Services has never been easier. Whether it's full customer control or comprehensive training, Novalera offers you the tools you need to get your business off the ground.
We handle most small business systems and work alongside vendors to provide you with the peace of mind you need to succeed.
At Novalera we do not do locked in support contracts. We pride ourselves on being here for you when you need us. Whether it's a short-term or long-term project, we are there for you every step of the way.


text:
Latin American Journal of Content and Language Integrated Learning
LACLIL is a bi-annual, open-access journal publishing
research and article from researchers whose work is related
to instructional practices implemented in language-learning
subjects or subjects taught through an additional language
as well as ICT and cultural issues related to language
learning. Articles, commentaries or teaching articles and
reviews on (but not limited to) the following areas are
- Educational approaches in which additional languages
are used for the learning and teaching of both content and
language (CLIL).
- Language learning, teaching, and/or evaluation
practices aimed at fostering cognition and metacognition
though language or content.
- The use of Information and Communication
Technologies (ICT) to foster communicative competences
enhancing cognition, metacognition, and the learning of
language, content, or both.
- CLIL methodology, assessment and/or evaluation
- CLIL curriculum design
- The learning of culture and/or intercultural
competences in or through additional languages.
- Teacher professional development initiatives in the
aforementioned areas.
Contact: Jermaine McDougald
E-mail: email@example.com
Subject: Language Learning, Language-Acquisition
Date Posted: 16th January, 2013