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ISRN Dermatology
Volume 2012 (2012), Article ID 158598, 6 pages
Effectiveness of Keishibukuryogan on Chronic-Stage Lichenification Associated with Atopic Dermatitis
1Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 2630, Japan
2Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 2630, Japan
Received 24 September 2012; Accepted 10 October 2012
Academic Editors: S.-C. Chao, M. Feinmesser, E. Pasmatzi, and J. F. Val Bernal
Copyright © 2012 Megumi Mizawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Atopic dermatitis (AD) is a common inflammatory skin disease with recurring episodes of itching and a chronic relapsing course. Keishibukuryogan (KBG) is a traditional herbal medicine, composed of five kinds of medical plants and has been administered to patients with blood stagnation in Japan. This study investigated the effect of KBG on the disease activity in AD () patients. AD patients were administered KBG for 4 to 6 weeks in addition to their prescribed medications. The results showed that the SCORAD index and VAS score were significantly decreased after the administration of KBG (). KBG also decreased the serum LDH level significantly (). The global assessment of the clinical response in SCORAD index showed that 88.5% of the patients with moderate improvement to excellent response () had a high lichenification score (lichenification score ≥2 in SCORAD). On the other hand, only 42.1% of the patients with no improvement to mild improvement () had a high lichenification score. Furthermore, long-term administration of KBG for 9–67 weeks showed a marked improvement in patients with a high lichenification score. Therefore, KBG was found to be effective against AD, particularly in cases presenting with lichenified lesions.
1. Introduction
Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by inflammatory infiltration, extensive pruritus, and a clinical course of symptomatic flares and remissions. The pathogenesis of the disease is now better understood, and important factors involved in the pathogenesis of this disease are genetic factors, skin barrier dysfunction, and immune dysregulation [1]. Lesions are often erythematous with edematous, weeping papules, and vesicles in the acute AD and lichenified thickened plaques in the chronic stage. The current treatment options for AD include topical agents, such as topical corticosteroids and oral antiallergic drugs. Effective long-term treatment is sometimes difficult due to the chronic, relapsing nature of this disease, thus creating a need to find better therapeutic options with minimal side effects that are well tolerated over the variable course of this disease.
Traditional herbal medicine has a long history, and it contributes to the prevention and treatment of various diseases. To date, only a few reports regarding the efficacy of traditional herbal medicines as a treatment option for AD have been reported [2–5]. Recent double-blind, placebo-controlled study showed considerably effective benefits in managing clinical signs of AD with Hochu-ekki-to [6].
Keishibukuryogan (KBG, Gui-zhi-fu-ling-wan in Chinese) is a traditional herbal medicine that has been widely administered to patients with blood stagnation for improving blood circulation. Matsumoto et al. explored a proteomic approach for the diagnosis of blood stasis in rheumatoid arthritis patients treated with KBG [7]. In addition, KBG is used to treat symptoms of peripheral ischemia such as cold extremities [8]. KBG is now one of the most frequently used traditional medicines in Japan and has been used clinically to treat various diseases, including skin diseases.
The purpose of this study was to evaluate the clinical effect of KBG on disease activity in AD patients in addition to conventional modalities.
2. Materials and Methods
2.1. Subjects
The study subjects included forty-five AD patients (23 males and 22 females; age, 14–41 years; mean age, 27.4 years). The diagnosis of AD was based on the Hanifin and Rajka criteria [9], and the patients had no other concomitant diseases.
2.2. Design of Study
The study was performed as a prospective self-controlled trial. These AD patients were administered KBG (TJ-25; 7.5 g per day) before meals three times a day for 4 to 6 weeks in addition to their prescribed medications, such as topical corticosteroids and oral antiallergic drugs. Patients were not allowed to take other medications during the study. Clinical and laboratory assessments were performed at week 0 and week 4 or 6. The study design was approved by the Human Subjects Committee, University of Toyama. All patients provided written informed consent in accordance with the ethical guidelines set forth in the 1975 Declaration of Helsinki.
2.3. Clinical Severity and Laboratory Assessments
AD patients were evaluated for general disease severity using the Scoring AD (SCORAD) index. The intensity part of the SCORAD index consists of six items: erythema, edema/papulation, excoriations, lichenification, oozing/crusts, and dryness. Each item can be graded on a scale 0–3. The subjective items include daily pruritus and sleeplessness. Both subjective items can be graded on a 10 cm visual analogue scale. The maximum subjective score is 20. A visual analogue scale (VAS) score (range 0–100) was used for the assessment of itching. A recently published study introduced a new evaluation tool, the global assessment of the clinical response for the SCORAD index, assigning a score of 0–4. Score 0–4 was defined as proportion of decrease in SCORAD values: 0—no improvement (0%); 1—mild improvement (1%–25%); 2—moderate improvement (26%–50%); 3—marked improvement (51%–75%); 4—excellent response (76%–100%) [10]. The serum lactate dehydrogenase (LDH) level, serum total IgE level, and peripheral blood eosinophils count were measured by laboratory tests.
2.4. Statistical Analysis
Data are presented as the mean values plus the standard error of the mean ± SE The statistical analysis was performed using paired t-test and the Wilcoxon signed-ranks test. A value of less than 0.05 was considered to be statistically significant.
3. Results
3.1. Assessment of SCORAD Index and VAS Score in AD Patients Treated with KBG
The results showed that the SCORAD index and VAS score were and before treatment with KBG. The SCORAD index and VAS score were decreased after the treatment with KBG (SCORAD index versus , ; VAS score versus , ; Figure 1). Therefore, treatment with KBG significantly improved AD-related objective and subjective symptoms. The serum LDH level was also significantly decreased ( versus , ; Figure 2(a)). However, no statistically significant differences were observed in IgE level and eosinophils count before and after the treatment (IgE versus , ; eosinophils count versus , ; Figures 2(b) and 2(c)).
3.2. The Global Assessment of the Clinical Response in SCORAD
The global assessment of the clinical response in SCORAD index showed no improvement in 9 patients, mild improvement in 10 patients, moderate improvement in 17 patients, marked improvement in 8 patients, and an excellent response in 1 patient. The percentage of no improvement to mild improvement (0%–25%) was 42.2% and moderate improvement to excellent response (26%–100%) was 57.8% (Figure 3(a)). The group with moderate improvement to excellent response patients had a high lichenification score (88.5%, lichenification score ≥2 in SCORAD index). On the other hand, only 42.1% had a high lichenification score in the groups with no to mild improvement patients treated with KGB (Figures 3(b) and 3(c)).
3.3. Observation of Long-Term Followup in Patients Treated with KBG
Five patients continued the treatment with KBG following the end of the clinical study. All these patients had a high lichenification score. These 5 cases included 1 case with an excellent response, 1 case with a marked improvement, and 3 cases with a moderate improvement at the end of the clinical study. After the subsequent long-term administration of KBG for 9–67 weeks, 3 cases demonstrated an excellent response and 2 cases showed a marked improvement (Table 1).
3.4. Safety
No adverse reactions in laboratory data were noted in any patients. No adverse events, including those of unclear causality with treatment with KBG, were observed in the study.
4. Discussion
There has been increased interest in the use of traditional herbal medicine to develop new therapeutic agents without a corticosteroid for AD treatment. KBG is frequently used in traditional Japanese and Chinese herbal medicine to treat several symptoms, including skin diseases. The preparation has demonstrated anti-inflammatory and free-radical scavenging effects. KBG is composed of five medicinal plants, Cinnamomum cassia Blume (Cinnamomi cortex), Paeonia lactiflora Pallas (Paeoniae Radix), Paeonia suffruticosa Andrews (Moutan cortex), Prunus persica Batsch (Persicae semen), and Poria cocos Wolf (Hoelen) (Table 2) [11]. Paeonol, one of the main components of Moutan Cortex, has an antithrombotic effect. Galloylglucose of Paeoniae Radix and polyphenol of Cinnamomi Cortex, reportedly have endothelium-dependent relaxative effects, as well as antioxidant effects [12]. Therefore, these effects were assumed to positively influence the vascular function, radical generation, and so on. Previously, KBG has been reported to improve AD-related objective and subjective symptoms. The serum Thymus and activation-regulated chemokine (TARC/CCL17) level was also decreased in accordance with the improvement of AD treated with KBG [13]. TARC is a member of the CC chemokine superfamily, produced by monocyte-derived dendritic cells, endothelial cells, and keratinocytes. TARC is a selective chemoattractant for cells expressing CC chemokine receptor4 (CCR4), such as Th2-type cells [14]. These results suggest that KBG may have an inhibitory effect on Th2-type chemokine production in addition to the traditional activity. KBG could probably be used more effectively to treat inflammatory disease involving Th2-type chemokines, such as AD.
KBG improves conjunctional microcirculation in patients with cerebrospinal vascular diseases [15], thus suggesting that it may have beneficial effects on hematological parameters such as blood viscosity and red blood cell deformability [16–18]. In addition, KBG has beneficial effect on endothelial function in patients with metabolic syndrome-related factors [19]. AD lesions are characterized by differences in the activation state of endothelial cells and the release of inflammatory mediators by and toward the vasculature [20]. Longstanding inflammatory skin due to itch-induced scratching causes cutaneous damage including endothelial cells manifested as lichenification. In this study, most of the patients with moderate improvement to excellent response had a high lichenification score (88.5%). On the other hand, only 42.1% of the patients with no improvement to mild improvement had a high lichenification score. These findings might be supportive that the vascular system is ultimately involved in clinical symptoms of AD, such as the chronic stage of lichenification.
KBG has a favorable effect on impaired glucose metabolism in type 2 diabetes by improving glucose intolerance, and it has been suggested that some of these effects are derived from the reduction of the TNF-α content in skeletal muscle [21]. Paeoniae Radix and Moutan Cortex contain many known active components which are common in both, including paeoniflorin, paeonol, oxypaeoniflorin, benzoylpaeoniflorin, and palbinone [22]. Paeoniflorin is a characteristic main principal bioactive component of Paeoniae Radix in KBG, which includes approximately 5.57% (w/w) paeoniflorin, and Moutan Cortex, which includes approximately 3.96% (w/w) paeoniflorin [23]. Paeoniflorin has many pharmacological effects, including anti-inflammatory and antiallergic effects [24]. KBG and paeoniflorin suppress the production of MIF, IL-6, IL-8, and TNF-α in Lipopolysaccharide-stimulated human dermal microvessel endothelial cells, which are the prominent cells in dermal skin [25]. Accordingly, KBG may have beneficial effects that result in the inhibition of inflammatory cytokines in HDMECs.
The long-term administration of KBG demonstrated marked improvement in patients with a high lichenification score. Consequently, it was believed that such long-term administration may be effective if patients show a tendency of remission in symptoms due to KBG administration for about a month. Therefore, KBG was found to be effective against AD, particularly in cases with lichenified lesions. These findings suggested that KBG may become a useful treatment for intractable AD in patients that have been treated with conventional modalities.
Nonstandard Abbreviations
AD: | Atopic dermatitis |
KBG: | Keishibukuryogan |
LDH: | Lactate dehydrogenase |
SCORAD: | SCORingAD |
TARC: | Thymus and activation-regulated chemokine |
VAS: | Visual analogue scale. |
Conflict of Interests
The authors state no conflict of interests.
This paper was supported by a Grant-in-Aid for Scientific Research (C) (no. 20591337) from the Japan Society for the Promotion of Science.
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Gunman kills 13 in Fort Hood rampage
President Obama addresses the Fort Hood community at III Corps Headquarters in Texas during a memorial service for the soldiers and civilians killed in a shooting rampage Nov. 5. Obama said no faith could justify the Fort Hood rampage, in an address Tuesday memorializing victims of the accused gunman, Major Nidal Hasan. "It may be hard to comprehend the twisted logic that led to this tragedy," Obama said in remarks.
President Barack Obama speaks at the memorial service at Fort Hood with the portrait of victim Sgt. Amy Krueger in the foreground.
U.S. Army soldiers salute as they wait for the start of memorial service for the victims of the shooting rampage in Fort Hood, Texas. Hasan, an army psychiatrist, killed 13 people and wounded 30 in the shootings.
Soldiers' Crosses, honoring those who lost their lives in last week's shooting, are positioned with victims' photos near the podium at the memorial service at Fort Hood, Texas.
Soldiers hug at the memorial service at Fort Hood, Texas, for the victims of last week's shootings on the base.
A soldier reads a bible during a church service at the First Air Calvary Division Memorial Chapel at Fort Hood, Texas, three days after the mass shootings on the sprawling military base. Maj. Nidal Malik Hasan, an Army psychiatrist set to be shipped overseas, opened fire at the Army post Thursday, authorities said. The rampage was the worst mass shooting ever at a military base in the United States.
A neighbor, who refused to give her name, lights candles below a wreath at the apartment complex where Maj. Nidal Malik Hasan lived in Killeen, Texas.
Mark Rodgers of Groesbeck, Texas, stands on the side of US-190 outside the main gate of Fort Hood in Killeen, Texas, showing his support following the mass shootings at Fort Hood last week.
Parishioners at Greater Vision Community Church mourn as the pastor offers prayers for those killed in the shootings at Fort Hood Army post in Killeen, Texas.
From left, deaconess Michele Carter, Tony Carter and Denise Jones worship at the Christian House of Prayer, praying for the soldiers killed and injured at Fort Hood in Killeen, Texas.
Jamie Casteel and her husband Scotty, right, of Duncan, Okla., stand outside the emergency room at Scott & White hospital in Temple, Texas, waiting to hear news of their son-in-law, U.S. Army soldier Matthew Cooke, who was injured in the mass shootings at Fort Hood.
Spc. Chad Rings, Spc. David Straub, and Spc. Ryan Howard, left to right, wait to enter Ft. Hood near the main entrance to the base on Nov. 5 in Killeen, Texas. The entire base was in lock down following the shootings.
Lt. Gen. Robert Cone adresses the media near the main entrance to Fort Hood on Nov. 5. in Killeen, Texas. Maj. Nidal Malik Hasan, an army psychiatrist who was upset about being deployed to Iraq shouted "Allahu Akbar!" and opened fire on an unarmed crowd at Fort Hood Army base, military officials said. Cone told NBC
show on Friday that nearby troops heard Hasan made the comment, which is Arabic for "God is great!" before the melee that killed one civilian and 12 soldiers.
People from the local community line the Scott and White Memorial Hospital hallways in Temple, Texas, to donate blood for the soldiers injured in the shooting spree at Ft. Hood earlier in the afternoon.
Soldiers from the 3rd Armored Cavalry Regiment storm the grounds of the Soldier Readiness Center in a show of force as they help in the apprehension of Maj. Nidal Malik Hasan on Nov. 5 at Fort Hood.
Officers from the Killeen police department wait for Fort Hood's Explosive Ordnance Device team to arrive at the apartment of Maj. Nadal Malik Hasan as they prepare to search his residence following the mass shooting at Fort Hood.
Phlebotomist Sumer Mosley takes blood from Pfc. Jose Estrada, with the 411th Military Police Company at Fort Hood, at Scott and White hospital in Temple, Texas. Estrada, said the he was prompted by the shootings of comrades to drive to Temple from the post to donate.
A police officer informs a woman, whose car has an "Army Wife" sticker, that the base remains closed following the shooting rampage at Fort Hood, Texas.
Monica Cain, 44, tries to contact her husband Sgt. Darren Cain, who was stationed at Fort Hood.
Emergency personnel carry the wounded at Fort Hood in this video grab from the scene. Thirteen people were killed in what authorities are describing as the worst mass shooting in history at a U.S. military base.
Sgt. Anthony Sills, right, comforts his wife as they wait outside the Fort Hood near Killeen, Texas on Nov. 5. Sills' 3-year-old son was still at a day care center on the base, which was in lockdown after a mass shooting earlier in the day.
Army Lt. Gen. Robert Cone gives a news conference Nov. 5 after a shooting in Fort Hood, Texas.
Spc. Ryan Howard of Niles, Mich., right, and Spc. David Straub of Ardmore, Okla., wait outside the gate for news about their fellow soldiers after the shooting at Fort Hood.
Cars wait to exit Fort Hood, Texas, after the base was locked down after a shooting Nov. 5.
Sgt. Fanuaee Vea, left, embraces Pvt. Savannah Green outside Fort Hood on Nov. 5 in Killeen, Texas. A gunman killed 13 people and injured 31 in a shooting on the military base that is a prime point of deployment for U.S. operations in Iraq and Afghanistan.
Sgt. Samuel Garrett was locked out of the military base upon returning from lunch at about 1:30 p.m.
City of Kempner police officer David Sheedy stops traffic from entering Fort Hood in the wake of a shooting on the base.
Spc. Jamie Deloe waits in the back of her SUV just moments after the emergency close down of the military was lifted and opened to all personnel.
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Intense man. Stay safe.
Plank Owner
"I watched approximately 45 seconds of 'Rock Of Ages'. It was like getting punched in the soul." - Abby Krizner
Longmont (north of Denver) in a fire truck.
One Life
Stay safe and dry Hans!
I just went through a flood at my house - water main break at the top of my street...my house only one flooded...just my luck!
measuring the wall, looks like I had about 11 1/4" of water so no shop vac was going to work for me, but I hope you don't see anymore water/damage. It's unreal the kind of damage water can do. Even after it's gone. I am having shortness of breath being at my house and may have to spend a night or two somewhere else.
Anyway hope everybody out there is safe.
Paul's Guitar - Charcoal || DGT Std. - Frost Blue Metallic ||DGT 10 Top - Yellow Tiger || DGT Artist - Faded Blue Jean Tobacco Burst || C.A.D. Custom 50 2-Channel - Slate || 2x12 Pine Cabinet - Charcoal
-Wishing you the best, Hans. I hope your family keeps safe and dry.
From the People's Republic of Maryland (One beer away from the West Street Shop)
Thanks for all the posts, PM's, texts, and email. I guess the news has spread across the country so I've been getting a lot of thoughtful messages.
My house is good. I seem to have plugged the leak. I can't say that life is very good for the people on the next street over. The creek changed course last night and decided to flow directly into a row of houses.
And it just started raining again. Ironic... this time last year we were praying for rain. Careful what you wish for!
Here's a look at life for the people one street over as they prepare for the next series storms headed our way.
Last edited by ]-[ @ n $ 0 |v| a T ! ©; 09-14-2013 at 11:32 PM.
One Life
My goodness Hans.....stay safe man, you've always got a place to stay in Minnesota is you need to escape!!! Praying that the rains stop now!
"He's kind of like a bear at a campsite...you think he's cute and kind of want to hug him, but in the end you know he's dangerous and is going to stomp on your tent and eat all your food..." - martysnarf
Jeez...those pictures!
I had 11" of water in my basement when it flooded this week...and it's a MESS...lost damn near everything downstairs...I can't imagine what so many people in Colorado are going to have to go through. My heart goes out to them.
It sucks that people have to suffer through stuff like this.
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text: On Wed, Jan 14, 2004 at 08:29:51PM -0600, John Cheyney wrote: > On Wed, 2004-01-14 at 16:54, Greg Schafer wrote: > > On Tue, Jan 13, 2004 at 09:21:40PM -0600, John Cheyney wrote: > > > I finally got my Glibc to configure and install. I had misread a couple > > > of steps and was hopelessly lost, so I just went back to square one. > > > > > > Now the problem comes with the next step. When I try to amend the GCC > > > specs file and I issue the commands as ordered > > > (SPECFILE=/tools/lib/gcc-lib/*/*/specs, etc) I get the following errors > > > > > > [1]26212 > > > bash: tempspecfile: No such file or directory. > > > > Are you cutting and pasting the commands for this as recommended in the > > book? If you're not real familiar with shell commands then this lockin step > > can go awry if you're not careful. > Yes. It still doesn't help. When I run the sanity check I still get > nothing. There is no point in running the sanity check if the commands are failing! You need to figure out why the commands are failing. Please cut and paste the below, press enter, then show us the output (and error if any) - be careful of wordwrap: SPECFILE=/tools/lib/gcc-lib/*/*/specs && sed -e 's@ /lib/ld-linux.so.2@ /tools/lib/ld-linux.so.2 at g' $SPECFILE > tempspecfile && mv -f tempspecfile $SPECFILE && unset SPECFILE If no error, then please physically "eyeball" the specs file and see if the intended change was made. This is all explained in the book. I fail to see why this is a problem for you.


text:
Granny's Mexican Slop
From sallyride13 Report abuse
This recipe was submitted by a reader and has not been tested in our kitchen.
Mama's idea of a taco salad
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Serves: 4
Yields: servings
Total Time: 40 min
Prep Time: 10 min
Cook Time: 30 min
U.S. | Metric | Conversion chart |
- 1 pound(s) lean ground beef
- 1/2 cup(s) water
- 4 tablespoon(s) chili powder
- 1 package(s) shredded lettuce
- 8 ounce(s) shredded mild cheddar cheese
- 1 large chopped tomato
- 16 ounce(s) Ranch Style Beans
- 1 package(s) Premium Saltines
- 1 bottle(s) Wish Bone French Dressing
- Mix beef, water and chili powder in 2 quart saucepan. Cook over medium heat, stirring occasionally, untill all water has evaporated. Add beans and stir until heated through. Remove from heat.
Spread 1/4 meat and bean mixture onto plate.
Sprinkle with cheese, lettuce and tomato.
Pour 2 tablespoons french dressing over all.
Serve with saltines.
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From Wikipedia, the free encyclopedia - View original article
The cabbage soup diet is a radical weight loss diet designed around heavy consumption of a low-calorie cabbage soup over the time of seven days. It is generally considered a fad diet,[1] in that it is designed for short-term weight-loss and requires no long-term commitment.[2][unreliable source?] It has inspired several copy-cats based around similar principles.
The typical claimed intent of the diet is to lose 10 pounds (4.5 kg) of weight in a week,[3] though nutritional experts point out that it is nearly impossible to lose that much fat within a week. This has lent credence to claims that much of the weight lost is water.
The origins of the diet are unknown, and it first gained popularity as a piece of faxlore in the 1980s. The cabbage soup diet has many names, usually linking the diet to a mainstream institution, including the "Sacred Heart Diet", "Military Cabbage Soup", "TJ Miracle Soup Diet", and "Russian Peasant Diet". All of the institutions named have denied a link with the diet.[4] As a general rule, most if not all forms of the diet emphasize that the dieter can consume as much cabbage soup as he/she wants.
Beverages are limited to water, and unsweetened fruit juice on days when fruit is allowed. This is a typical outline of the diet:[5]
Many individuals and medical professionals are critical of the diet.[6] Most of the weight lost is water and not fat, and therefore not permanent. The amount of calories per day while on the diet is far lower than what is considered safe. In addition, the recipe for the soup as often given has an extremely high sodium content, usually to make it palatable, and the diet provides practically zero protein for several days at a time. Many people report feeling weak and light-headed during the course of the diet.
On a practical level, the most common forms of the soup recipe have been criticized as being bland, though spicy variations have appeared. Even so, the blandness of the soup means that few manage the entire seven days, and often report feeling nauseous whenever they smell the soup toward the end of the week-long diet. It has also been noted that flatulence is a common side effect of the diet.


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ST. LOUIS (KMOV) -- A 20-year-old woman participating in the OccupySTL protest reported to police that a man sexually assaulted her while she was in her tent on November 8, three days before tents were removed by the city. A St. Louis City police officer says the mayor could have prevented it.
Brian E. King, 38, was charged with first degree sexual misconduct after police said he crawled into the victim's tent and touched her breast. The assault happened on November 8 at the encampment that used to be set up in Kiener Plaza.
A blogger from St. Louis posted a video of St. Louis Police Sgt. Gary Wiegert talking about how the mayor could have prevented the attack. In the video, Wieger says, "I believe if the mayor would allow the police department to do its job and take care of this problem and not allow these tents to be set up, this sexual assault wouldn't have happened. This is what happens when politics gets involved with police work."
Wiegert says he is speaking for himself, not the St. Louis Police Department. Wiegert is a former head of the St. Louis Police Officer's Association. Today, he is a registered lobbyist for the Tea Party and an outspoken opponent of local control.
Police Chief Dan Isom declined a request for an interview on the allegations.
The mayor's chief of staff says that Wiegert's accusations are all about politics, and the staff points out that St. Louis did not have problems like other cities.
Occupy member John Mills says that crimes happened before the occupation, and the perpetrator in this case was not a regular participant. He does not think it should reflect on their movement.
The full video is available for viewing below.


text: TOP 10 Top 10 Dating Top 10: Perverted Behaviors To Stop Back to Top ▲ Top 10: Perverted Behaviors To Stop 6 Inappropriately touching her in public Share on Facebook Share on Twitter 0 Shares Thinstock A quick pinch of the butt or a nibble of the neck: there are more than a few touchy-feely moves you can make in public to get her a little aroused and keep the relationship sexual and playful. There are, however, some places on her body that you should never touch in public -- no matter how few eyes are watching at the moment. If you can't keep your hands off of her in public, she will think you don't know how to behave in any situation. If you're willing to cop a feel in a crowded mall, who says you won't do it in front of her boss at an office party or at her parents' wedding anniversary party. We're not completely against some PDA, but do keep it in check. Next Page TOP 10 9 8 7 6 5 4 3 2 1 Comments Show Comments More Like This Promoted Around the Web Special Features


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Prayer Circles
Read Prayers. |
deedee1212 10/5/2004 13:46 |
Dear Lord we pray that you will wrap your loving and comforting arms around "C". We ask Lord that you send him wisdom, strength, courage, and guidance. We also ask Lord that you send someone to him that he can love and share his life with. In Jesus name we pray, Amen. |
ceejaysmom 8/11/2005 00:29 |
Dear Heavenly Father, please reach out to "C" the way you did for me when my life was very similar. Guide him to the life You have prepared for him. Dear Lord comfort him in this time & I pray that he is aware of the love that You have for him and never feel lonely. I know that he will find peace and structure in the time that You have planned for him. Please just be with him on his journey and provide a loving companion on whom he can always trust and depend on. Amen |
Has problems James J 02/12/2008
My Uncle Dennis Worthington 02/12/2008
My marriage Kat Mounce 02/12/2008
A good friends mother, who has cancer everyone who needs prayer universal 02/12/2008
Pray for Michelle and Carlos N. 07/08/2008
"This prayer is to help us sell our home."
Pray for Donald H. 07/07/2008
"The love of my life has cancer."
Pray for Amanda B. 07/06/2008
"Please pray for my daughter and her unborn child."
Pray for Janice A. 07/05/2008
"One of my most favorite people in the whole world needs your prayers today. Please spread this and include Janice in your daily prayer."
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I just don't think you can go wrong with pizza and pasta, and love to try new ways to eat it. Pizza is one of my very favorite foods and I tried some panzarotti pizza served at a restaurant in Boston.
I didn't know quite what to expect, but was pleasantly surprised. Anytime you have meat, melted cheese, spices and pasta you have a good combination!
The nice thing about filled pasta, is that even if you are a vegetarian, there are so many ways to fill your pasta without meat that are just as tasty.


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Vitamin A (retinol) is necessary for the function of light-sensitive nerve cells (photoreceptors) in the eye's retina. It also helps keep the skin and the lining of the lungs, intestine, and urinary tract healthy and protects against infections.
Carotenoids, such as beta-carotene, are pigments in fruits and vegetables that give them their yellow, orange, or red color. Once consumed, carotenoids are slowly converted to vitamin A in the body. Carotenoids are best absorbed from cooked or homogenized vegetables served with some fat or oil.
Drugs related to vitamin A (retinoids) are used to treat severe acne and psoriasis. Whether taking vitamin A, beta-carotene, and retinoids helps reduce the risk of certain types of skin cancer is being studied. However, the risk of certain cancers may be increased after taking beta-carotene supplements.
Vitamin A deficiency is common in areas of the world where people do not eat enough of certain foods:
For example, the deficiency occurs in southern and eastern Asia, where rice is the main food.
Disorders that impair the intestine's absorption of fats can reduce the absorption of vitamin A and increase the risk of vitamin A deficiency. These disorders include chronic diarrhea, celiac disease, cystic fibrosis, certain pancreatic disorders, and blockage of the bile ducts. Surgery on the intestine or pancreas can have the same effect. Liver disorders can interfere with the storage of vitamin A. Most multiple vitamins contain little or no vitamin A.
An early symptom of vitamin A deficiency is night blindness, which is caused by a disorder of the retina. Soon thereafter, the whites (conjunctiva) and corneas of the eyes may become dry and thick—a condition called xerophthalmia. Xerophthalmia is particularly common among children who have a severe deficiency of calories (energy) or protein, which includes inadequate intake of vitamin A. Foamy deposits (Bitot spots) may appear in the whites of the eyes. The dry cornea may soften and deteriorate, and blindness may result. Vitamin A deficiency is a common cause of blindness in developing countries.
The skin becomes dry and scaly, and the lining of the lungs, intestine, and urinary tract thicken and stiffen. The immune system does not function normally, making infections more likely, particularly in infants and children.
Children's growth and development may be slowed.
The diagnosis is based on symptoms and a low level of vitamin A in the blood.
If people have problems seeing in the dark, eye tests, such as electroretinography (see Electroretinography), may be done to determine whether vitamin A deficiency is the cause.
If people have conditions that put them at risk of developing this deficiency, they should take vitamin A supplements.
People who have the deficiency are given high doses of vitamin A for several days, followed by lower doses until vision and skin improve. Infants should not be given high doses repeatedly because such doses can be toxic.
If symptoms persist after 2 months, doctors usually check for a disorder that impairs fat absorption.
Too much vitamin A can have harmful effects (toxicity). For example, taking daily doses 10 times the RDA (recommended daily allowance) or greater for a period of months can cause toxicity. Sometimes toxicity results from taking special formulations of high-dose vitamin A to treat severe acne or other skin disorders. A smaller dose can cause toxicity in infants, sometimes within a few weeks. Sometimes children accidentally take a very high dose, and toxicity occurs quickly.
Consuming large amounts of carotenoids (which the body converts to vitamin A) in food does not cause toxicity because carotenoids are converted to vitamin A very slowly. Usually, no symptoms occur. However, when very large amounts are consumed, the skin may turn a deep yellow (called carotenosis), especially on the palms and soles.
High-dose supplements of beta-carotene may increase the risk of cancer, but carotenoids consumed in fruits and vegetables do not seem to increase this risk.
Consuming too much vitamin A over a period of time can cause coarse hair, partial loss of hair (including the eyebrows), cracked lips, and dry, rough skin, which may peel. Later symptoms include severe headaches, increased pressure within the brain (intracranial pressure), and general weakness. Bone and joint pain are common, especially among children. Fractures may occur easily, especially in older people. Children may lose their appetite and not grow and develop normally. The liver and spleen may enlarge.
Consuming very large amounts of vitamin A all at once can cause drowsiness, irritability, headache, nausea, and vomiting within hours, followed by peeling of the skin. Pressure within the brain is increased, particularly in children, and vomiting occurs. Coma and death may occur unless vitamin A consumption is stopped.
Taking isotretinoin Some Brand Names SOTRET (a vitamin A derivative used to treat severe acne) during pregnancy may cause birth defects. Women who are or who may become pregnant should not consume vitamin A in amounts above the safe upper limit (3,000 micrograms) because birth defects are a risk.
The diagnosis of vitamin A excess is based mainly on symptoms. To confirm the diagnosis, doctors often also do blood tests to measure the level of vitamin A.
Treatment involves stopping vitamin A supplements. Most people recover completely.
Last full review/revision October 2014 by Larry E. Johnson, MD, PhD
celiac disease
Previous: Thiamin
Next: Vitamin B6


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Hub Group, Inc. Announces Stock Buy Back Plan
DOWNERS GROVE, Ill., Nov. 26, 2012 /PRNewswire/ -- Hub Group, Inc. (Nasdaq: HUBG) announced today that the Board of Directors has authorized the purchase of up to $25 million of its Class A common stock. This authorization expires December 31, 2013. Hub intends to make purchases from time to time as market conditions warrant. Hub intends to hold the repurchased shares in treasury for future use.
ABOUT HUB GROUP: Hub Group, Inc. is a leading asset-light freight transportation management company providing comprehensive intermodal, truck brokerage and logistics services. The Company operates through a network of offices and independent agents throughout the United States, Canada and Mexico.
CERTAIN FORWARD-LOOKING STATEMENTS: Statements in this press release that are not historical, including statements about Hub Group's or management's intentions, beliefs, expectations, representations, projections, plans or predictions of the future, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are inherently uncertain and subject to risks. Such statements should be viewed with caution. Actual results or experience could differ materially from the forward-looking statements as a result of many factors. Factors that could cause actual results to differ materially include the factors listed from time to time in Hub Group's SEC reports including, but not limited to, our annual report on Form 10-K for the year ended
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SOURCE Hub Group, Inc.
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text: Am I doing something wrong? Or missing something? This is RIGHT after Act 2 ends. I'm(as Gromit) supposed to make Wallace breakfast...but can't. There's no toast and he doesn't want any honey. I start the breakfast contraption, it works fine, only the pan flips the finished egg onto the kitchen counter and then the egg disappears(I'm guessing because it's supposed to land on a plate or plate-like object...?). I've looked everywhere and "selected" everything, including combining the one object I was able to pick up(the tennis raquet) with everything, and nothing is happening. I can't leave the house, nor go downstairs. There's nothing for me to do. It's like that episode of Buffy where she's caught in a time loop and can't progress at all. Any help?


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Starting Your Weight Training Routine Getting started is the biggest hurdle for most people and it takes some analysis to make sure the right routine is used. There is a great deal of information available on weight training. One can start on the Internet by finding numerous websites that provide information for the beginner. These websites many times will provide "how to" videos showing the correct way to start your training program. For some people, a well written book can layout a good routine for the beginner.
Types Of Equipment Weight training will involve using weight bearing equipment such as dumbbells, barbells or machines that will use pulleys or cables to lift certain levels of weights. These pieces of equipment are easy to purchase and usually can be kept for use in the home.
As mentioned previously, the weight lifting routine can be developed for beginners then expanded to more advanced levels as time and strength progresses. A good starting point is the dumbbell arm lifting routine since it can be done easily and does not require a visit to the gym.
The dumbbell comes in different weights so the beginner can decide which is most comfortable. The exercise is for bicep strengthening and will contribute to building muscle. A good procedure is called the dumbbell curl with either sitting on an incline or standing while executing.
Find A Good Weight Trainer Shoulder strengthening is also an important workout and can be achieved with barbells or the machines having pulleys. As progression is made at this level, it may be advantageous to visit the weight training recreation center that many communities now have and seek the advice of a trainer. The trainer will be able to modify your routine, if necessary.
Keep Injuries At Bay As with any sport, weight lifting can have injuries if it is not done properly. That is why failure to execute the exercise properly is important. Good form is essential. Using the back for lifting instead of the legs may cause a problem. A warm up is also a good start before the routine. Stretching improves the flexibility which will prevent injury and it contributes to more strength and stamina. Any occurrence of pain should be heeded immediately and the weight training exercise should be stopped.
The success of weight training is determined by setting up a weight training routine and sticking to it. It is important to start slowly and add to the routine after the weight training strengthening becomes evident. Once the weight training becomes part of your routine, there should be a number of health benefits that become apparent.


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OBLIVION TRAILER 3 (Video) – The sci-fi thriller Oblivion is set in 2073 when Earth is nothing but scraps due to the tremendous damage the alien invasion left over 60 years ago. Tom Cruise stars as Jack Harper, a repairman who's in charge of repairing the drones that patrol the skies. However, an unknown capsule lands on Earth and he encounters a woman (Olga Kurylenko) who seems to know him, but he has no idea who she is. Jack also runs into Malcolm Beech (Morgan Freeman), a resistance leader who is against leaving his home. Together, they fight for their right to stay, while aliens and drones have a different idea. Oblivion also stars Andrea Riseborough and Melissa Leo.
PLOT: A court martial sends a veteran soldier to a distant planet, where he has to destroy the remains of an alien race. The arrival of an unexpected traveler causes him to question what he knows about the planet, his mission, and himself.
- US – April 19, 2013
- France – April 10, 2013
- Australia, Russia & Germany – April 11, 2013
- UK – April 12, 2013
Watch the trailer below:


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Q&A: What is the best e cigarette for the money?
Question by email@example.com: What is the best e cigarette for the money?
I am wanting to start using the e cigarette and need to know which brand puts out enough vapor for a heavy smoker, is rechargeable, doesn't have a cord hanging down from it, has inexpensive refills, ect.
Best answer:
Answer by Sarah
NONE!! dont buy any cigeretts of any kind! give up! Everything is so expencive but if you insist then use ecigarettschoice.com
Know better? Leave your own answer in the comments!


text:
Kabul: The latest implementation of Islamic Finance is very slow in war-torn Afghanistan citing the economic crisis and legal obstacles in the country. Nonetheless, USAID-sponsored efforts have started paying off as the shariah-compliant loans are playing vital role in the Afghani farm industry.
The Afghan government is using Islamic financial contracts to extend credit to farmers in areas where conventional banking has not fully satisfied demand for funds.
The Agricultural Development Fund (ADF), set up in 2010 through a $100 million grant from the US Agency for International Development (USAID), offers both conventional credit and Islamic financing.
About $11 million of its loans approved between May 2011 and April 2012, or 70 percent of them, were shariah-compliant, the ADF said. Islamic finance obeys a religious ban on payment of interest and instead pays lenders with returns on real assets.
Demand for such financing has been particularly strong in rural communities because people there tend to be conservative, said Juan Estrada-Valle, Acting Chief Executive of the ADF. In Afghanistan's conventional banking sector, official lending rates hover around 15 percent, according to the World Bank, and farmers have been forced to buy agricultural inputs from traders on credit at inflated margins that in some cases exceed 40 percent.
"Credit has the potential to revolutionize Afghan agriculture, enabling commercial farmers and other agribusinesses to grow at a rapid pace and contribute to the growth of rural communities," Estrada-Valle said.
The ADF has had to overcome perception problems with its Islamic contracts. Some customers and their religious advisors were under the incorrect impression that Islamic loans should be free or cheaper than conventional ones.
While customers already knew of Islam's prohibition on interest, borrowers had to be educated about other principles including the fact that non-payment by a solvent borrower is a sin, Estrada-Valle said.
The ADF's loan portfolio includes an all-women saffron association in Herat, apple farmers in Wardak province, and an industrial-scale producer of agricultural machinery in Jalalabad.
As of October 2012, the ADF had provided loans to more than 15,000 farm households in 30 of Afghanistan's 34 provinces; it said that it expects to reach 60,000 farmers by the end of 2014.
Its Islamic contracts follow the Hanafi school of thought, the predominant version of Islamic law in Afghanistan. The fund has so far developed five shariah-compliant contracts which cater to specific needs, said Natalie Schoon at British-based financial consultancy Formabb, who was involved in the project.
One contract incorporates a down payment to allow hiring of labor and tools for the harvest period; others are designed bearing in mind crop cycles.
Estrada-Valle said that the ADF initially intended to make funds available to local financial institutions for on-lending to agricultural enterprises, but the financial institutions appeared not to have any appetite for this.
So the ADF changed its focus to lending through non-financial institutions to farmers as well as agriculture-related enterprises; typical intermediaries include associations, cooperatives and large-scale farm stores.
A law covering independent Islamic banks has yet to be approved by Afghanistan's parliament, and this is hindering the overall development of Islamic finance in the country. But since the ADF was set up as a fund, it is not subject to banking regulations, Schoon said.
Last May, the central bank said it was considering issuing short-term sukuk to help the government raise money and develop the financial markets.


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The South Carolina-Auburn baseball game scheduled for Friday has been postponed due to rain. The teams will play a doubleheader Saturday at Noon ET and 5 p.m. ET.
Click here for the original story.
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Forbes magazine seems to be taking its slogan--"capitalist tool"--a bit too literally.
In 1989 (6/26/89), Forbes printed a full-page house ad in its pages, soliciting insurance company advertising for a special section: "Clearly there has never been a time when it has been more critical for the insurance industry to tell its story.... Be part of that story. Advertise your company's services in 'Insurers Outnumbered,' appearing in the Oct.16, 1989 issue of Forbes." That issue of Forbes happened to feature a cover story attacking personal injury lawyers for winning money from the "outnumbered" insurance companies.
The special section marked the beginning of an aggressive campaign of editorial support for insurers, culminating in another cover story that took on a major insurance industry foe: Ralph Nader. The piece (9/17/90) alleged that Nader was in the center of a "web of interests" consisting of a couple dozen public interest groups, some of which have only the most tenuous connection to Nader.
One of the groups said to be in Nader's "gravitational field" is the Fund for Investigative Journalism. "I've never dealt with Nader," Fund chair Frank Greve told Extra!. "I've felt the gravitational pull of Venus more than I've felt Nader's."
Forbes' main criticism of Nader was that he accepts money from trial lawyers, perhaps prejudicing him against those outnumbered insurance companies. By the magazine's own figures, a little more than 1 percent of the income of the Nader "empire" comes from lawyers; by contrast, 7 percent of Forbes' advertising comes from insurance companies (Washington Post, 9/11/90).
Forbes also charges Naderites with espousing "left-wing looneyism." The only example it could produce: opposition to a capital gains tax cut. The magazine attempts to "expose" Ralph Nader's affluent lifestyle by accusing him of living in his sister's townhouse. While Nader affirms that he lives in his own apartment, moving in with one's sibling is not normally thought of as a sign of conspicuous consumption.
In a syndicated column written before the Forbes attack appeared (9/5/90), Nader pointed out that the magazine's support for the insurance industry has been quite profitable. In the 24 issues starting with the October 16, 1989 special edition on "outnumbered" insurance firms, insurance ads accounted for at least $6.2 million in revenues, a jump of 30 percent over the previous 24 issues. "It's a magazine that believes it can sell the Forbes family name to the highest bidder," Nader told Extra!.