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When Shuhei Yoshida took centre stage at Gamescom to demonstrate how the PS4 works from the player's perspective, the whole process was unusually genuine.
It's now obligatory for live demonstrations to come with a games developer who has committed all the stage directions to memory - they know exactly where to stand, where to look, what to do and when. It's always intensely hectic, impossibly perfect and inevitably explosive footage of games pretending to be films.
But when Yoshida fired up Killzone Shadowfall (complete with a - shock - genuine loading screen) he stumbled onto the battlefield, fired aimlessly into the air, and paused to take a screenshot of a tree. (That very image, by the way, was posted live on his Twitter feed).
This was a demonstration made perfect by showing its imperfections. It was confident, relaxed and authentic - which says a lot about Yoshida's confidence in his next generation system.
In an interview with CVG following the Gamescom press conference, we discuss the final stages of PS4, the future for indies, VR headsets and the outlook for Vita.
From a games line-up perspective, I think one of the biggest differences between Microsoft and Sony is that one system has triple-A exclusive games and the other has many indie titles. How would you evaluate the differences in those two approaches?
Sure, I don't think we purposefully decided we were going to release so many exclusive indie games on the PS4. I think we decided some time ago to support indie developers - it's just that the indie games ecosystem has taken off since then.
There were smaller digital games since the launch of the PS3, but nowadays there are so many that become huge hits. It's amazing how many talented people are now independent and make their own games.
Do you feel that is the future for the industry?
Yeah, absolutely. Because of the digital platform, and because everyone in the world can reach the same audience. That's pretty healthy. And these guys aren't interested in hiring PR agencies, or lawyers or sales reps! [Laughs] They want to focus on making great games, and that's really healthy.
It's very natural for us [the traditional industry] to be very conservative with the games we make, especially at larger studios. So we need these small guys to come up with something unique.
That's interesting, do you want Sony Worldwide Studios to make more of these smaller digital titles too?
Yeah, it's not necessarily the focus, but always it's healthy for our developers to try something new - especially the studio has a franchise. Some people work on the same franchise for six years, so it's good that our teams can unleash their creative talent. So we don't limit what the internal guys do, so they can start some smaller projects, but they tend to make big things.
At the Sony Gamescom press conference there was a renewed focus on Remote Play - which gives gamers the option to play their PS4s on their PS Vitas. What I haven't seen much of is that used for dual-screen gameplay - asynchronous gameplay. Is there still an interest in this?
Yeah, interested, but... we did dual-screen with LittleBigPlanet and it's kind of interesting, but you have to tell people when to watch the portable and watch the TV, but people don't have four eyes! So I think that's why we are focusing on Remote Play. I like playing console games in bed on Vita.
With regards to PS Vita, it has struggled to match the kind of sales Sony achieved with PSP. And considering the decline of the handheld market in general, I wonder if you think Vita will be Sony's final handheld? In the long-term, is this a business you feel you can still pursue?
Yeah I think we can still pursue it, and I don't think we have to make that decision now. Also, the distinction between the portables and mobile is [blurring], because there are all kinds of hybrids, different form factors and operating systems can still be conceived, in terms of how we characterise portable and mobile. We still like PS Vita and we know people who buy it really like it.
So, I'm going to have to ask The Obligatory Last Guardian Question.
Oh okay, so yeah we are still making it [laughs] - Ueda-san just Tweeted about Shadow of the Colossus HD on PS Plus. So we are still waiting for the right time to announce it. To re-announce it! [laughs]
Would it require a huge leap in imagination to suppose it's now a PS4 game?
So, we have decided not to discuss this yet.
So, we're a few months away from the release of the PS4, and you must be delighted by the response it's received.
Yeah so far, we are very excited and happy. But internally we have a lot of work to do. We are focused on getting everything done for launch before we have a chance to really take a look at what everyone's been saying. But I'm very excited by what people are saying.
The positive comments must help drive the teams.
Yes so the hardware and software teams are heads-down day and night, and because they have been looking at the same thing for a long time, they can't really get a feel for how it's going to be perceived. So when they hear the responses from fans, it's a huge morale boost.
"We are focused on getting everything done for launch before we have a chance to really take a look at what everyone's been saying."
With regards to the PS4 system, do you feel it is innovative enough to stimulate new ideas from developers and reach out to new people?
So, the system has to be good before we can talk about innovation. We looked at all the options in terms of technology, and all the potential devices to include in PS4, and we feel we've made a very good choice. It's really up to developers how they use the technology, and it's what they make from this technology that will make people say - wow, that is really innovative.
If you look at the PS4 and it's nearest rival, those two consoles are very similar, and I wonder if the industry is doing enough when it comes to the collective responsibility of growing the sector and reaching out to new people.
Yeah, usually just looking at the big titles, maybe we are just chasing the same people. Which is why the smaller developers are so important and will bring new ideas to the platform. I think we will see more great things come out in a few years that will again reach out to a broader market.
One innovation that a lot of people are talking about is Oculus Rift - I know you have tried it yourself.
Yes and I really like it.
I do wonder if that is a technology Sony is looking to pursue itself.
Y'know, we're Sony, so we have lots of different things and different ideas in R&D. When it come to researching things, we are doing a lot of things that we can't talk about.
finally, there's a substantial games line-up for PS3 this year. When it comes to Sony Worldwide Studios, is the shift entirely on PS4?
So, in terms of larger teams the shift is now on PS4, but we will continue to support PS3 in slightly different ways.


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Coppermine wrote:Comedy Central has a show called "Mind of Mencia." It's horrible. He points out fairly obvious observations that have been joked about 10 years ago. So last night he says "I hate stupid people and stupid things. Like, hooked oh phonics is a program that helps you learn to read by recognizing letters. And the phone number is 1-800-ABCDEFG"About 10 people laugh."Ah, i see some of you aren't laughing. That's because you're stupid and don't get it... the number is ABCDEFG stupid! You can't read. Get it?"Oh man, it was a sad performance, and they even put it on television. Anyone else catch this lousy show?Sorry, i know it's off topic, but the illiteracy thing made me think of it.
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What does VHQ mean in US Government?
This page is about the meanings of the acronym/abbreviation/shorthand VHQ in the Governmental field in general and in the US Government terminology in particular.
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"VHQ." Abbreviations.com. STANDS4 LLC, 2015. Web. 6 Mar. 2015. <http://www.abbreviations.com/term/219887>.
VHQ also stands for:
- Vasudeva Happiness Quest
- Very High Quality
- VHQ Entertainment, Inc.
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@SarahGen-- I've used instant hot packs before and I never had this problem. I don't think it's a danger if it's handled properly. The plastic is very thick and it won't be damaged easily. But you shouldn't allow kids to use them by themselves.
You could get hot gel packs but those are not instant. They have to be boiled or warmed up in the microwave. Instant hot packs all contain chemicals. Lots of people use them without any issues.


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DACF Home → Divisions & Programs → Division of Forestry → Conditions Report No. 4 2008
Forest & Shade Tree - Insect & Disease Conditions for Maine
July 18, 2008
The 2008 season so far has been a reasonably good one in terms of adequate moisture and near normal temperatures. Forests and most landscape and ornamental trees across the state appear to be in good general condition. However, as the warm and dry summer weather of the past two weeks continues, trees will become increasingly stressed, and health problems can quickly arise. This is especially true for landscape stock that has been established this spring, or even within the past one or two years. If not already underway, good soil moisture management practices should be considered now for all woody transplants. This most obviously includes adequate watering. Watering during the evening hours, overnight, or early morning is best. Various soaker-hose and drip irrigation systems have proven to be most effective, both in terms of efficiency of delivery to root systems, and in terms of water usage. In addition, the judicial use of loose mulches in planting beds and around root areas will also help reduce evaporation rates. Don't wait for trees to start showing stress symptoms before providing relief. Affording such attention now to these most susceptible plant materials will insure their health throughout the remaining summer, and will prepare them for the fall and winter seasons as well.
Hemlock Woolly Adelgid Found in Saco
Ferry Beach State Park ranger, Janet Mangion, discovered hemlock woolly adelgid while pruning trees along the park access road in late June. Since then we have been working with park personnel to determine the level of infestation and how to address areas such as trails that are at high risk of spreading the adelgids. Survey results indicate a low-level, spotty presence of the adelgid in the park. Park rangers have pruned infested hemlock material likely to be encountered by hikers, picnickers and other park users. An integrated management approach will be developed as we gain a better understanding of the extent of this infestation. This infestation is several towns removed from the generally infested area, and intensified surveys of hemlock stands in Kennebunk, Kennebunkport, Arundel and Biddeford are planned. Readers in the area are encouraged to look for signs of the adelgid on hemlocks they encounter. Look for sessile, white woolly masses on the undersides of hemlock twigs, attached at the bases of needles. Report any suspect findings to the Insect and Disease Lab at: (207) 287-2431; 50 Hospital Street, Augusta, ME 04330.
A link to the Department of Conservation press release can be found at the bottom of the hemlock woolly adelgid information page.
Purple Traps Deployed to Detect Emerald Ash Borer
The Emerald Ash Borer (EAB), a metallic woodboring beetle from Asia, was first found in North America near Detroit, Michigan in 2002. It has since spread to eight states and two Canadian provinces. One of the most recent finds was made in June 2008 in the province of Quebec, southwest of Montreal. That is only 200 miles and less than a four hour drive from the Maine border. Just last week EAB was found in Virginia.
The larvae of this beetle feed on the inner bark of ash trees disrupting the flow of water and nutrients and kill the tree by girdling it. The adults chew on the leaves a bit but do no significant damage to the trees. Because the larvae are hidden during development, this insect is easily moved on firewood.
The Maine Forest Service, Maine Department of Agriculture and USDA Animal Plant Health Inspection Service have hung over 70 traps in ash trees on campgrounds, nurseries and other likely sites for EAB detection. If you run across one of these traps, you may think somebody has gotten their kite tangled in a tree. The large purple traps - triangular cardboard prisms coated with a sticky substance - are set high in the tree canopy.
Other methods of detection employed by the agencies and their cooperators include trap trees - in which live ash are girdled to attract the insects - and biosurveillance. Biosurveillance uses a native wasp that is a metallic woodboring beetle predator to monitor for the presence of EAB. More information about biosurveillance efforts can be found on our Website.
Hemiptera Blitz at Acadia National Park
This year the Maine Forest Service is once again co-sponsoring an Insect Blitz with Acadia National Park (ANP). This year the focus will be on True Bugs, Order Hemiptera. This group covers insects with beaked mouthparts and incomplete metamorphosis and includes long-horned bugs, hoppers, spittlebugs, and cicadas. Although aphids, scales, mealybugs, jumping plant lice and whiteflies are also in this order, the blitz will not focus on them this year. The Blitz this year is scheduled for August 9-10, 2008 at Schoodic Point, Winter Harbor, Maine.
The goal of the Blitzes is to help ANP learn what lives in the park so that they can do a better job of protecting everything that is a part of the ecosystem. This benefits all of us by increasing our understanding of what lives here with us in Maine. To date Blitzes have covered ants, moths & butterflies, beetles, flies and spiders. Each year new species for Maine have been added to those already known to exist here. Experts and amateurs join together to collect as many different species as can be found in 24 hours and then pin, label and identify each specimen. The ANP Blitzes attract taxonomists from all over North America and have gained high acclaim.
Two Somerset County Towns Added to the Gypsy Moth Quarantine Area
The Maine Forest Service uses pheromone baited traps to detect gypsy moth populations in towns north of the gypsy moth quarantine. Each year after the leaves drop Maine Forest Service, Maine Department of Agriculture and USDA Animal Plant Health Inspection Service personnel look for gypsy moth egg masses in areas with high trap catches. As a result of egg mass surveys conducted last year, the Somerset County towns of Pierce Pond Township and T3 R4 BKP WKR have been added to the Federal Gypsy Moth Quarantine Area. More information about the gypsy moth quarantine can be found on our Website.
Arborvitae leafminer (4 species) – These tiny larvae feed or "mine" between the top and bottom layers of the cedar foliage causing it to turn brown. The larvae then pupate either in the mines or outside them depending on the species. Most adult leafminers will have emerged as moths, mated and laid eggs by now so any control work should be put off until August when the larvae hatch and begin mining the foliage. See issue 3 for control recommendations.
Aspen Serpentine Leafminer (Phyllocnistis populiella) – Quaking aspen in Aroostook county from the Allagash down to Patten were heavily infested with serpentine leafminers winding their way through the leaf tissue. This tiny moth usually does not create lasting problems for the trees.
*Fall Webworm (Hyphantria cunea) – Small fall webworm nests are beginning to be apparent and numbers are expected to be high again this year. Same drill as in past years - look for loose tents containing tiny, grayish, fuzzy caterpillars on alder, apple, ash, beech, birch, cherry, elm and oak. Clip and destroy these small developing tents to help reduce the problem locally. Carbaryl (Sevin), Diazinon, acephate (Orthene) and Bt are registered for use against this pest.
Hickory Tussock (Lophocampa caryae) - Although Maine does not have a lot of hickory we do have hickory tussock moths and this year the larvae have been spotted in both northern and western Maine feeding on birch. The larvae feed gregariously on leaves of a number of trees including birch, black locust, quaking aspen, elm, butternut and of course hickory. When nearly fully grown the larvae then feed singly and wander quite a bit before pupating on the ground. Although these are lovely looking black and white caterpillars they can cause a rash if the unsuspecting person picks them up for a closer look. Although hickory tussock may be locally abundant, they rarely cause much damage to trees.
Japanese Beetle (Popillia japonica) – The grubs of Japanese beetles have finished feeding on the roots of your lawn and ornamentals and now the adults are out chowing down on over 300 different types of plants! Trees attacked by Japanese beetle include apple, elm and birch as well as other hardwoods (UMO Extension Fact Sheet).
Maple Trumpet Skeletonizer (Epinotia aceriella) – The larvae of the maple trumpet skeletonizer has started feeding on maple trees in central Maine. Last year this insect was widespread across the state and may be again this year. Generally the damage caused by the feeding is minimal and is mostly an esthetic problem (more information, off-site).
Mountain Ash Sawfly (Pristiphora geniculata) - The larvae of the mountain ash sawfly are feeding now and damage is apparent on trees infested with this pest. If numbers do not appear to be that great, wait until next year and either clip off the infested branches or treat when the larvae have just hatched in late June.
*Oak Twig Pruner (Anelaphus parallelus and A. villosus) – Oak branches on the ground this time of year are usually a clue that longhorned beetles have been boring in the branches. A look at the end that has been cut will reveal a smoothly chewed end with an oval hole packed with what looks like sawdust. Break the branch and it is hollow, split up the branch and there will be a larva in there all set to overwinter. Picking up the branches and destroying them will help reduce the beetle population if the dropped branches are an esthetic problem.
Oak Skeletonizer (Bucculatrix ainsliella) – The first generation of oak skeletonizer larvae are finishing up feeding on the leaves of oak trees along the coast. They will then spin down on silken threads and form cocoons that look like ribbed grains of rice. A second generation of larvae will begin feeding in August. The larvae feed on the underside of the leaves leaving the veins and making lacy looking damage on the leaves. In some years damage can be heavy enough to weaken trees and cause branch dieback. There are recommendations for raking and destroying leaves to reduce the population but I have observed so many cocoons formed on other trees, screens and other objects that I am not sure how effective it would be (more information, off-site).
*White Pine Weevil (Pissodes strobi) - It's not too late to correctively prune infested white pine leaders. Although larvae have dropped out of the leaders in southern and central Maine, pruning will still help trees to retain their upright stature. Prune back to the first healthy whorl of branches and remove and destroy infested branches (the larvae may still be in the leaders in northern Maine and destroying them will help reduce the population.). Then select the best lateral of this top whorl and prune off all remaining laterals leaving the single best lateral to form a new leader.
*Yellowheaded Spruce Sawfly (Pikonema alaskensis) – Numbers of yellowheaded spruce sawfly seem to be up slightly this year with more damage observed and increased numbers of calls. Larvae are gaining size now and defoliation is becoming obvious on roadside spruces. Control now with Spinosad or carbaryl to limit damage.
Branch Dieback of Maples (Verticillium albo-atrum; Verticillium dahliae) - Maples in several towns and suburban areas are now showing symptoms of Verticillium wilt. Symptoms of this widely distributed disease have been observed in particularly high levels in Lewiston and Bangor. Trees in many other areas, including Augusta, Dresden, Presque Isle, Rome, and Topsham have also been seen with symptoms likely the result of Verticillium infection. Norway maples appear to be most susceptible to the disease, but red and sugar maples are also susceptible. Because Norway maple is an exotic and widely planted as a "street" tree the disease is more apparent in urban and suburban areas.
The Verticillium fungi that cause the disease are soil-borne, and initially infect the tree via root wounds. Once inside the tree, spores of the fungus can be transported via the water conduction system. Acute symptoms at first include wilting, drying, and browning of leaves, usually of one or a few individual branches. Death or "flagging" of individual branches is very conspicuous, and indicates that the sapwood of the current year has been infected. Severely infected trees may have up to half or more of the total crown area damaged in a single year, but this is the exception. Trees that have lost more than half the crown will likely need to be removed and replaced. More often the symptoms only slowly progress to other branches in subsequent years, or may be intermittent, with no further branch dieback for one or more years.
Trees showing wilt symptoms in only a few branches or a small portion of the crown can be helped by promoting good tree growth. Watering to prevent or alleviate drought stress is important, especially this time of year. Removal of the infected branches as soon as practical after the disease is recognized can also help reduce the rate of spread. Diseased branches (those with wilted leaves or flagging) will not recover. Pruning out the infected wood can provide the tree time to overcome the infection. It is especially important to clean pruning tools with alcohol or a weak solution of bleach after each cut, so that the fungus is not transferred to other branches or trees.
Fir-Fern and Fir-Fireweed Rusts (Uredinopsis spp., and Pucciniastrum epilobii, respectively) – These two foliage diseases of balsam fir occur to a greater or lesser extent every year, and are common throughout the state. Although there have been no reports of significant problems with these diseases this year, Christmas tree growers especially will want to assess disease status within their local areas. Now is the best time to eradicate the alternate host plants (that is, the ferns and/or the fireweed) where they may occur within 100 – 150 feet of susceptible balsam fir. There are herbicide formulations (glyphosate and others) that will control both ferns and fireweeds. On some sites, re-treatment for a second year may be necessary for best control. Fireweed is now in flower, and its conspicuous purple-pink flowers will indicate areas that may warrant control measures. Additionally, it is especially important to treat the fireweed early, before it goes to seed.
Sudden Oak Death Survey (Phytophthora ramorum) – Based on surveys of four watersheds last year (Gardiner, Brunswick, Wells, and Fryeburg) and three watersheds this year (Clinton, West Paris, and Standish) Phytophthora ramorum has not yet been found in natural forest areas in Maine. The current survey of 2008 has included three sample periods, one each in April, May, and June. All sampling has been negative for pathogen presence. Sampling will resume at the latter three sites in September, October, and November.
Currently, the disease is known to occur in natural forest stands (primarily oak species) only in California, Oregon, and Washington. The Maine survey is being conducted because this pathogen has a wide woody-plant host range, and because many susceptible species are important to the nursery and landscape trades. Therefore, the potential exists that the pathogen may be moved from infested to non-infested areas in soil or by introduction of infected nursery stock.
Conditions Report No. 4, 2008


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Nick Foles Fractures Hand, Vick To Start Andy's Last Game As Eagles Coach
Philly.com – Andy Reid announced Monday that an MRI revealed a hariline fracture in the second metacarpal in quarterback Nick Foles' throwing hand, suffered just before halftime of Sunday's loss to the Redskins. The second part of the stunner: Instead of going with Trent Edwards, who has been backing up Foles lately, Reid plans to start Michael Vick in what is very likely to be the final Eagles game for both Reid and Vick. "That's the direction we're going in, as we speak," Reid said. Reid said Vick, cleared after suffering a concussion Nov. 11, is excited, something Vick spokesman Chris Shigas confirmed to your Eagletarian. Shigas said Vick cherishes the opportunity to "leave it on the field," and obviously, getting a shot at showing potential 2013 employers he is healthy and sharp can't hurt, either. Reid didn't really offer a clear rationale for the turnabout from hacving Vick as the inactive, healthy third quarterback against the Redskins to making him the starter again the next day. Observers had hypothesized that if something should happen to Foles, the Eagles didn't need a quarterback they are likely to discard coming in and muddying the waters with an electrifying performance, and that Vick wasn't looking to take any more brutal hits in a season that has been full of them. But if any of that were true, Edwards would be starting against the Giants, who still can make the playoffs if theyb beat the Eagles and several other dominoes fall. "He's had a couple of weeks of practice here," Reid said of Vick. "I thought the first week, he was a little bit rusty out there, I thought this past week, he threw it around well, he feels good … He obviously deserves an opportunity to play."
This team couldn't get any weirder. Wait I forgot — the Jets. This team almost couldn't get any weirder.
Why not go with Trent Edwards? Because fuck Trent Edwards, that's why. There's no way Andy Reid would struggle through having to watch Trent Edwards fail against the Giants in his last game on the Eagles sidelines. No Way. So you've gotta respect the fat man's resolve right in the face of HOLY SHIT THAT'S AWKWARD to throw Vick in there so they can both have their last games together. It's almost poetic.
Fuck a draft position, I hope they kill the Giants on Sunday.


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Just Add Water would like to do a MGS HD remake
Yesterday, VG247 published an article which suggested that Hideo Kojima, the legendary creator of Metal Gear Solid, was actively looking for a studio willing to remake MGS1 with the power of the new Fox Engine. This however originated from a mistranslated interview, as Kojima later confirmed on Twitter, although he admitted that he likes the idea.
Not wasting any time, today Just Add Water published an open letter to Kojima-san on their website, stating that they would love to be able to work on such a project and pointing out their experience with remakes.
Dear Mr Kojima,
We read with great excitement on VG247 that you were looking for a studio to work with to develop a Metal Gear Solid remake using the Fox Engine, that your team has been hard at work creating.
We at Just Add Water feel ideally positioned to do the remake justice for several reasons:
- We have experience working with legendary IP (Oddworld Inhabitants) and treating the subject matter with the respect it deserves.
- Many members of our team are huge Metal Gear fans, with very good knowledge of the source material.
- We really, really want to do it.
For evidence of our abilities, please check out not only the HD treatment of Oddworld: Stranger's Wrath, released on PlayStation3, VITA and PC, but the current re-creation of Abe's Oddysee, titled Oddworld: New 'n' Tasty.
We eagerly await your response.
Love and cuddles,
The JAW Team.
We'll update this if Kojima answers their call publicly, but gamers are already very excited at the mere thought. What do you think? Should Konami give the green light? There actually has been already a MGS remake (called Twin Snakes, it was developed by Silicon Knights and released originally on the GameCube system), but the Fox Engine could bring everything to life once again.


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Tumorigenesis is a multi-step process that requires activation of oncogenes and inactivation of tumour suppressor genes. Mouse models of human cancers have recently demonstrated that continuous expression of a dominantly acting oncogene (for example, Hras, Kras and Myc) is often required for tumour maintenance; this phenotype is referred to as oncogene addiction. This concept has received clinical validation by the development of active anticancer drugs that specifically inhibit the function of oncoproteins such as BCR-ABL, c-KIT and EGFR. Identifying additional gene mutations that are required for tumour maintenance may therefore yield clinically useful targets for new cancer therapies. Although loss of p53 function is a common feature of human cancers, it is not known whether sustained inactivation of this or other tumour suppressor pathways is required for tumour maintenance. To explore this issue, we developed a Cre-loxP-based strategy to temporally control tumour suppressor gene expression in vivo. Here we show that restoring endogenous p53 expression leads to regression of autochthonous lymphomas and sarcomas in mice without affecting normal tissues. The mechanism responsible for tumour regression is dependent on the tumour type, with the main consequence of p53 restoration being apoptosis in lymphomas and suppression of cell growth with features of cellular senescence in sarcomas. These results support efforts to treat human cancers by way of pharmacological reactivation of p53.
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CHOC Children's Specialists
1201 W La Veta Ave
Orange, CA 92868
phone: (714) 509-4373
fax: (714) 509-4072
map & directions
Web Site:
Recognized for his leadership and expertise, Dr. Dhar serves as medical director of CHOC Children's neonatal intensive care unit (NICU), Dr. Dhar specializes in neonatal critical care, with particular interests in cytokines, nitric oxide, extracorporeal membrane oxygenation (ECMO) and high-frequency oscillating ventilation (HFOV) performed at CHOC.
On the forefront of innovative treatments, Dr. Dhar participates in numerous research studies. As the principal investigator in the NICU Tracheal Aspirate Study, Dr. Dhar and his associates evaluate tracheal aspirate leptin and parathyroid hormone-related protein levels in predicting the development of bronchopulmonary dysplasia.
Driven with a passion for better outcomes for neonates and children, Dr. Dhar is a coinvestigator in the multicenter National Children's study which examines the effects of the environment, as broadly defined to include factors such as air, water, diet, sound, family dynamics, community and cultural influences, and genetics on the growth, development, and health of children from before birth until age 21 years. The goal of the study is to improve the health and well-being of children and contribute to understanding the role various factors have on health and disease.
Dedicated to clinical excellence, Dr. Dhar is board certified in pediatrics and neonatology. Prior to joining CHOC Children's, Dr. Dhar attended medical school at the Postgraduate Institute of Medical Education and Research in Chandigarh, India. He served his pediatric internship and residency at All India Institute of Medical Sciences in Chandigarh, and Gauhati Medical College in Gauhati. Dr. Dhar completed his fellowship training at the Hospital for Sick Children in Toronto and UC Irvine Medical Center in Orange County.
Highly regarded in his field, Dr. Dhar was voted as one of Orange County's Top Doctors in consecutive years, and has been recognized as a Physician of Excellence by the Orange County Medical Association for the past 10 years.
Dhar V, Perlman M, Cutz E. Autopsy in Neonatal Intensive Care Units, Utilization Patterns and Associations of Clinicopatholoic Discorances; Journal of Pediatrics 1998; 132: 75-9
Dhar V, Hallman M, Bry K. Interleukin-1 Alpha Upregulates, the Expression of Surfactant Protein A in Rabbit Lung Explants; Biology of the Neonate: 1997; 71: 46-52
Rationale and Potential Use of Cytokines in Prevention and Treatment of Neonatal Sepsis, Clinics in Perinatology, 1998; 25-3: 699-710
Co-investigator in an ICMR funded project, Project No. 3/1/2/29(232)78-RB, entitled "Comparative Study of Schick Test and Indirect Hamagglutination Test for Diphtheria in Children".
Co-investigator in the National Perinatal Epidemiology Unit (UK) OSIRIS Surfactant Trial 1990: "Open Study of Infants at High Risk of or with Respiratory Insufficiency – the role of Surfactant.
Paper entitled "Immune Status of Children and Response to D.P.T. Vaccination, Published in Indian Journal of Pediatrics, vol. 49:501, 1982
Paper entitled "Plasmapheresis in Acute Guillian Barre Syndrome", Indian Journal of Pediatrics vol. 20:867, 1983
Paper entitled "Cockington Normogram as a Guide to Phototherapy in the Management of Neonatal Hyperbilirubinemia–Evaluation of Indian Neonates", Indian Pediatrics vol. 21:229, 1984
Paper entitled "Seip Lawrence Syndrome", Indian Journal of Pediatrics vol. 49:881, 1982
Paper entitled "Relactation with Metochlorpropomide", Published in Indian Pediatrics
Epidemiological Survey on the prevalence of Gr. A Streptoccal Vulvovaginitis in Children in a large health district at Romford, United Kingdom


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Battle of Bunker Hill
From Andover Answers
Several Andover residents were killed at the Battle of Bunker Hill: Samuel Bailey William Haggett Joseph Chandler Philip Abbot
Two Black soldiers from Andover fought in the battle: Philip Abbot who was killed Salem Poor in whose honor a commerative stamp was issued.
- Historical Sketches of Andover, by Sarah Loring Bailey, (974.45 Bai), page 321-327.
- Andover in the American Revolution (R974.Har)
back to Main Page


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The premier public radio showcase for contemporary music serving up an eclectic blend that includes blues, rock, world, folk, and alternative country.
Originally published on Fri March 9, 2012 2:29 pm
Grammy-winning producer and record-label owner Aaron Levinson is in the studio to introduce us to a corner of Latin roots music called cumbia. Affiliated with a number of professional recording academies and societies, this internationally known musician also owns a recording studio in Ardmore, and has consistently received recognition for his work with Latin music. In the studio today, Levinson and host David Dye talk about the origin and evolution of cumbia, including its late resurgence in popularity in New York.
Originally published on Fri October 17, 2014 8:32 am
Alabama Shakes, a soulful rock 'n' roll quartet, is riding a well-deserved wave to fame. Since the release of its self-titled debut in 2011, the band has entranced listeners with its diverse and energetic songs. Alabama Shakes' style is marked by lead singer Brittany Howard's powerful voice and the group's irresistible energy. Together, they enthusiastically blend rock with soul, country, blues and roots.
Grace Woodroofe is only 21, but her warm and wise music marks her as an old soul. Born in Australia, the blues-folk singer was discovered by actor Heath Ledger when she was 16. The self-taught guitarist and singer subsequently relocated to California to record and develop her sound.
Czech musician Markéta Irglová has spent much of her life becoming a darling of the folk and indie-rock scenes. At 13, she began collaborating with Glen Hansard and his band The Frames.
When the genre-defying Melissa McClelland married Juno nominee Luke Doucet, it seemed inevitable that the Canadian power couple would collaborate soon. After all, they'd had overlapping but stylistically diverse careers. McClelland was featured in Degrassi and won Best Americana Song at the 6th Annual Independent Music Awards, and her collaboration with Jesse Cook for his track "It Ain't Me Babe" spent three weeks at No. 1 on Billboard's world-music charts.


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Very Good Recipes of Buttermilk from Cooking with Mel
There are 3 Buttermilk recipes on the blog Cooking with Mel. (375 on all the blogs)
Click on the title of a recipe or the photo of a dish to read the full recipe on its author's blog.
Simple Buttermilk Pancakes
By Cooking with Mel
07/29/11 17:02
Happy Friday! I wish I had something happy and delightful to report about this weekend, but no can do. This weekend Nick and I are going back to Pennsylvania. This time, however, we are going to be in Lancaster County – Nick's stomping grounds. I am not...
Add to my recipe book
Buttermilk Oven Baked Chicken & Waffles [with an award on the side]
By Cooking with Mel
07/26/11 17:44
Happy Tuesday Foodies! I am having a difficult time writing a post today for so many reasons. I wish I could talk about each of those things that are troubling me and are now manifesting in a way that is affecting my ability to write a post. It is not important...
Add to my recipe book
Peanut Butter m&m Buttermilk Pancakes
By Cooking with Mel
07/15/11 15:40
Happy Friday Everybody! Guess what? Nick comes home tomorrow! The only bad part is his flight comes in very early in the morning, which means I have to get up at the crack of dawn to get out to the airport. It would not be such an issue, but I have not...
Add to my recipe book


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Help with planning entertainment for events:
Chris, Thanks so much for playing for us again this weekend. Everyone really enjoyed the music you played and we've had so many great comments! Can't wait for you to come back in September...
I was at a party in which Casius Daydream played, I honestly have to say they are the most tight sounding cover band I have ever heard. Such fun and energetic, class people as well...
David - just wanted to say thanks for last Friday - enjoyed by all - you're an absolute gent - a superb singer and great entertainer - we were very lucky to have been entertained by such a great talent - really would love to see you perform again at some point - thanks again - John
You played brilliantly and we were both so pleased. Matthew's son Sam was absolutely in awe of your music to the point we are expecting a string instrument to be added to the ever growing Christmas list. His comment later that evening was there was nothing you couldn't play...
LastMinuteMusicians.com is the UK's leading live entertainment portal. More than just a directory - it's the most convenient way to find the right entertainment for your event. Visitors can browse profiles, read reviews, listen to audio, watch videos and choose from a rapidly growing selection of the best musicians, bands, entertainers and related companies. search for entertainment or register your act.
One of our bands Men in Blue were booked for the Royal Wedding! MIB performed to 300,000 people in Hyde Park for the Royal Wedding, which has apparently gone down in history as the largest ever UK gig!
"Being the only band to perform as the 'Wedding band' after the first kiss was just fantastic..." Read the full interview
We specialise in providing our clients with the best musicians, bands and entertainers for their wedding reception or ceremony. As well as wedding music, we provide live music for all sorts of other events including functions and corporate parties. Look at our entertainment agency to find out about the acts that we manage. Have a look at our entertainment directory to find any sort of entertainment for any event in the UK. No need to sign up to contact our members, each profile has a quick and easy enquiry form that sends an email instantly!
The choices of wedding entertainment and music can vary a lot from person to person, but most wedding receptions include jazz or classical of some sort, followed by a more 'dancey' band for the evening entertainment. We've got the whole of the UK covered with our selection of Wedding Bands.
Choosing the right wedding ceremony music and wedding reception music is essential to the success of any wedding so hiring a quality wedding entertainer or band is paramount! For other services like wedding dj's, please visit our entertainment services page.
Good live wedding bands are versatile in terms of style and usually try to cater for the wide range of tastes your guests are likely to have. Please see our wedding music page for more information about hiring a band. as well as tips on how to plan your perfect day. If you are looking for music for the ceremony you might want to book an organist.
Our UK entertainment directory covers the whole of the UK and is packed full of live bands for hire - jazz bands, string quartets, function bands, harpists etc. that can be booked for public or private events. You can also book party bands, Latin bands, rock and pop bands, singers, guitarists, pianists and pretty much anything else you can think of!
Hiring a live band for the first time can be daunting! Have no fear, we can help. If you are at all unsure about any of the bands featured on our site, or if you have any questions related to booking live music in general, we're always happy to advise you.
If you need help finding the right band for you please get in touch via our contact page. We have a specific page for Birthday Party Bands which features some of our top picks.
Tribute bands are always popular at events –everyone enjoys dancing to covers. Make sure you think about the range of guests that will be at your event. You might not want to book a Bon Jovi tribute band at an event with your grandma present!
Function bands in London are simply live bands that perform at functions. The function could be an awards ceremony, party, dinner, conference – pretty much any event that requires live music... As there is quite a wide range of styles and standards, shop around a bit and you will find the right function band for you. We get a lot of enquiries for covers bands and band for weddings, parties and events.
Every year there are a few dates which get booked up really quickly. Here are some dates that we expect to be very busy so if your event corresponds to any of these then please make sure that you arrange all of your entertainment as early as possible.
LastMinuteMusicians.com entertainment agency is a one-stop shop for all your entertainment needs! Our London-based band agency can provide live musicians & entertainers to perform for wedding ceremonies and receptions, or music for parties / corporate events. We also have entertainment articles (see above) to help you with event planning as well as our entertainment resources section.
Live entertainment for a corporate party can be hard to find... When you are organising your corporate event entertainment it is likely that you will want to book live music bands as well as a corporate entertainer or two (such as a magician) to keep your guests entertained. Lots of our London wedding bands are also well suited to corporate events.
If you're looking for jazz bands for hire in London or need to hire UK jazz bands for any purpose at all then we can help. We specialise in supplying the best jazz musicians available today.
Choosing a band for hire is a major part of organising your event and making the right choice can often mean for your guests the difference between a successful, memorable occasion and a wasted evening out that should quickly be forgotten.
There are, however, thousands of bands out there, as well as numerous agents trying to convince you to part with as much money as possible. Here follows some advice to help make the right choice and avoid the price pitfalls.
The style of band you choose to hire will reflect the atmosphere you are trying to create at the event. You may be interested in our article on live music entertainment, which will offer more information on this. Style will firstly reflect the purpose of the music in the event; background music, dancing, show case, homage etc and will secondly be in keeping with the tastes of the expected guests.
Any themes designed into the evening should also be reflected by the choice of musical style. For example a rat pack band might be suitable to accompany a 50's theme night or a movie stars evening, but would not be suitable for an English country garden, or 70's disco!
For background music, options may include a jazz trio or swing band, a woodwind ensemble or cocktail piano player. A tribute band, 60s-00's band, function band, funk band or Latin band might cater for dancing, although other popular choices to hire are a big band, a ceilidh band with caller or even a Mexican Mariachi band!
Generally speaking, the price of your band will depend on two things: a) the number of musicians and b) how long they are required for. Remember that you are paying professionals for their time, so even if they are not performing they are still entitled to charge for their time. Keep this in mind when planning your entertainment and try not to have the musicians hanging around for too long.
By the same token, however, bands will also need breaks, usually at least 15 minutes for every hour and an experienced event planner will plan these to coincide with other entertainment or interim periods such as speeches. As a guideline, individual musicians will usually charge between £150 and £300 for most functions.
This will be more if they are required for long periods of time. By multiplying this out therefore, it should be possible to estimate a reasonable cost for the band you are hiring. £900 for example, therefore, would be a high price to pay for a trio. Less than £450 and you might be getting a great bargain, but be sure to exercise caution here.
You usually get what you pay for and scrimping on the price might mean scrimping on the quality too. General good advice for any entertainment service is to make sure you have as much information as possible on an act before engaging them.
Professional acts will have promotional packs with information, photos, repertoire and normally audio or visual samples of their work. You can find a band for your event today by using our band search shown at the top of any page of LastMinuteMusicians.
Significant extra charges to the above are to be expected if you are booking a 'name' or if the band use any particular equipment or include spectacular displays in their performance.
Other reasonable additional expenses, which may be added to the total cost, include travel expenses and any parking. It is customary also to provide bands with food and refreshments, so this should also be budgeted for. Good luck in choosing your band!
Last Minute Musicians has 1404 members, our newest member is Keysworth String Quartet (updated Thur 05 Mar 2015) and we've had >54,000 visitors in the last 30 days.
© 2003-2015 Lastminutemusicians.com Ltd, Company #06544335 registered in England & Wales. By using this web site, you agree to our use of cookies and our terms of usage.


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BLUEBARN Theatre to complete building with Min|Day architectural firm
The BLUEBARN Theatre is honored to announce today that, following a successful feasibility study, it has engaged Omaha/San Francisco based architectural firm Min|Day to undertake the design and construction phases for the new theatre to be built at 10th and Pacific Streets. Jeffrey L. Day, AIA, the Omaha-based principal of Min | Day, will be the lead design architect on the project. The BLUEBARN plans to break ground on its new home in spring 2014 and open its 2015-2016 Season in the new space.
About Min | Day
The architectural partnership of Min | Day, established in 2003, spans offices in San Francisco, California, and Omaha, Nebraska. Capitalizing on these divergent locations, Min | Day is founded on a recognition of the ever-increasing complexity of the American landscape. The practice draws on the principals' backgrounds in art, landscape and building design to provide informed and flexible design that serves a wide variety of clients from individuals to art institutions, urban to rural sites, and projects ranging from furniture to large buildings.
About Jeffrey Day and E.B. Min
Jeffrey L. Day, AIA is Professor of Architecture & Landscape Architecture and Director of the Architecture Program at the University of Nebraska-Lincoln. He graduated magna cum laude from Harvard College with an AB in Visual and Environmental Studies and received a Master of Architecture from U.C. Berkeley. At UNL Jeff runs FACT (Fabrication And Construction Team), an award-winning, academic/professional collaborative design lab that offers architecture students a forum for exploration of the complex relationships between thinking (conceiving, designing, theorizing) and making. FACT is a "do-tank", a lab in which ideas and new knowledge are developed though action as well as thought. Working with Min | Day, FACT engages design intensive projects and creative, non-profit clients in collaborations that span design and construction. FACT is a winner of the inaugural 2013 ACSA Design Build Award.
E.B. Min, AIA is the San Francisco based principal of Min | Day. An honors graduate of Brown University with dual concentrations in Art History and Studio Art, she began her architectural studies as a cross-registered student at Rhode Island School of Design. She received her Master of Architecture from the University of California at Berkeley and she is a licensed architect in California. E.B.'s experience in the office of a noted landscape architecture firm nurtured her interest in the integration of landscapes and buildings. E.B. has taught at U.C. Berkeley and is an Adjunct Professor in the Masters of Architecture Program at California College of the Arts in San Francisco. E.B. is a director of the AIA
California Council and a former director of the AIA San Francisco chapter.
Beginning in Fall 2012 and continuing throughout the design and construction phase, The BLUEBARN will raise $7 million via a capital campaign chaired by community leaders Kate Noble Weitz and Nancy Mammel.
We will break ground on the building—the first stand-alone theater project in Omaha in a generation—in Spring 2014.
Early fundraising success has included an initial $2.5 million in leadership gift commitments, along with the donation of real estate at 10th and Pacific.
A destination building planned by nationally recognized architects and designers
The Progression New Theatre Design project is a collaborative venture involving a variety of participants, including an internationally renowned architectural firm, a theatre design consultant, local architects and planners, and the BLUEBARN. We will produce a contemporary and flexible venue designed on an intimate scale, featuring public spaces created for interaction while showcasing the work of local artisans and native building materials. The facility design will interweave refined architectural aesthetics with the work of local artists skilled in such arts as ceramics, brick work, and barn building.
Having such a theater space in our city will attract national and international attention, and add to Omaha's reputation as a cultural destination.
The embodiment of Omaha as a world-class city
Omaha is singular for its extraordinary public-private partnerships, its vibrant and growing arts and cultural scene, and its reputation for innovative thinkers, well-run businesses, and a growing creative class. BLUEBARN—and its future home on 10th & Pacific—is the confluence of all this and positions our city for the next decade of cultural transformation.
The BLUEBARN is a growing and vibrant organization, committed to the highest level of artistic quality while serving an ever-expanding audience. Our current home has served us well and is much beloved by our audience and artists but is inadequate as our ambitions and audience continue to expand.
With our audience base and our artistic ambition increasing annually, BLUEBARN has outgrown its cherished but challenging space at 614 South 11th Street and will build a new home at 1001 Pacific Street, in Omaha's emerging South Old Market District.
Since 1989, The BLUEBARN has produced over 100 shows. As we approach our 25th Anniversary Season, The BLUEBARN is in the best artistic and fiscal condition in its history, and routinely sells out performances for the entire run of shows. In recognition of almost 25 years of excellence, The BLUEBARN Theatre was awarded the Organizational Achievement Award at the 2012 Nebraska Governor's Arts Awards.
Building a future for arts in Omaha through the cultivation of talent
As Omaha's creative class expands, the cultural institutions that incubate Omaha's artistic leaders must grow to meet their needs. Omaha's most established artists are attracted to work at The BLUEBARN; a stand-alone space will expand the depth and breadth of BLUEBARN's function as a nurturer of Omaha's artistic talent.
With the enthusiastic backing of our loyal patrons, donors and the larger Omaha philanthropic community, the future home of The BLUEBARN will propel the organization forward for the next 25 years of truth, beauty, and artistic progression.
Overall Goal: $7 million
$4.5 million for the design and construction of the theatre building.
$1.5 million to create a sustaining fund to subsidize the operation and maintenance of the organization.
$1 million in new annual gifts over five years to ensure institutional growth during initial years of operation in the new building.
Your pledge of support to the campaign is vital to the success of this project and the organization's continued vibrancy for the next 25 years of progression.
Our time is Now.
Gifts to the campaign can be pledged over several years and can include planned and deferred commitments.
The BLUEBARN Theatre is a 501(c)3 organization and gifts are tax-deductible.
"The BLUEBARN is a unique, offbeat theater which attracts younger audiences and theatregoers who want to experience off-Broadway-style productions. The BLUEBARN will be a great addition to the revitalization of the South Old Market cultural and arts district."
Nancy Mammel
Mammel Foundation
"The BLUEBARN Theatre is one of the most ambitious, innovative and cheerily subversive theater groups I know of. I am proud they are part of Omaha's growing cultural landscape and we must support them."
Alexander Payne
"Opera Omaha is committed to collaborative partnerships with like-minded organizations such as The BLUEBARN Theatre. We see great potential for sharing operatic work on the new BLUEBARN stage."
Roger Weitz
General Director, Opera Omaha
Many of the details are still in development as we work toward our 2014 groundbreaking—and there is much fundraising still to do. In the meantime, we welcome your input and feedback. Please contact us through facebook (www.facebook.com/bluebarn), or through email.


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What's New
- Reorder packs.App Description
Teaching, playfully - it's fun and easy! Forest, farm, sea, and many of their inhabitants - let you child explore them all. Acquaintance with the world begins with a game!Include 12 game worlds (and more regular updates):
Merry Christmas (NEW!)
Playground (NEW!)
Country Picnic (NEW!)
Ancient world
Mystical Halloween
Fancy numbers
Friendly Zoo
Wonderful forest
Happy farm
Blue sea
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App Changes
January 29, 2014 Price Decrease: $0.99 -> FREE!
January 29, 2014 New version 1.2.1
November 02, 2013 New version 1.1.4
September 26, 2013 New version 1.1.3
July 15, 2013 Initial Release


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With the holiday season less than a month away, I'm featuring products that I hope are not only Chic but also Cheap.
Today's feature is a Swing Cardigan, the newest trend in the city. It's versatile enough to dress up or down. Wear it with a pair of skinny jeans and ankle boots or with a fitted dress and heels, whichever way you go, you'll be a show stopper!
At the $11.99, you can snatch up one for your mom, sister, best friend and even get a FEW different colors for yourself! To purchase go to metrostyle and enter Swing Cardigan in the Search box.
What do you think? Is it Chic AND Cheap?
Let us know in a comment!
Happy Friday! Have a chic-filled day!
Don't miss out on future Chic & Cheap posts. |


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Antioxidant enzymes and cancer
- Md. Asaduzzaman Khan,
- Mousumi Tania,
- Dian-zheng Zhang,
- Han-chun Chen
- … show all 4 hide
Rent the article at a discount
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Get AccessAbstract
Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components, causing several diseases. Damage in DNA is responsible for cancer formation and progression. However, several enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase etc. act as antioxidants to influence oxidative stress. Polymorphisms in these enzymes are supposed to be associated with DNA damage and subsequently the individual's risk of cancer susceptibility. This review article aims to further elucidate the relationship between antioxidant enzymes and cancers by summarizing the findings of some of the important study concerning expression levels and genetic polymorphisms of antioxidant enzymes in cancer patients.
- Champe PC, Harvey RA, Ferrier DR. Intermediary metabolism. Champe PC, Lippincott's Illustrated Reviews: Biochemistry. 4th edition[M]. Lippincott Williams & Wilkins. Philadelphia, USA. 2007; p: 69–82, 148.
- Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease[J]. Int J Biochem Cell Biol 2007; 39: 44–84. CrossRef
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- Frederiks WM, Bosch KS, Hoeben KA, et al. Renal cell carcinoma and oxidative stress: The lack of peroxisomes[J]. Acta Histochem 2009; Jun 3 [Epub ahead of print]
- Hussain SP, Raja K, Amstad PA, et al. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: oxyradical overload diseases[J]. Proc Natl Acad Sci USA 2000; 97: 12770–12775. CrossRef
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- Surapaneni KM, Sadagopan C. Status of Lipid peroxidation and antioxidant enzymes in patients with carcinoma of breast[J]. J Med Sci Res 2007; 1: 21–24.
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- Yamamoto T, Sakaguchi N, Hachiya M, et al. Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger[J]. Leukemia 2009; 23: 761–769. CrossRef
- Petit E, Courtin A, Kloosterboer HJ, et al. Progestins induce catalase activities in breast cancer cells through PRB isoform: correlation with cell growth inhibition[J]. J Steroid Biochem Mol Biol 2009; 115(3–5): 153–160. CrossRef
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- Yoshizawa K, Willett WC, Morris SJ, et al. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer[J]. J Natl Cancer Inst 1998; 90: 1219–1224. CrossRef
- Brooks JD, Metter EJ, Chan DW, et al. Plasma selenium level before diagnosis and the risk of prostate cancer development[J]. J Urol 2001; 166: 2034–2038. CrossRef
- Leaver MJ, George SG. A piscine glutathione S-transferase which efficiently conjugates the end-products of lipid peroxidation[J]. Marine Environ Res 1998; 46: 71–74. CrossRef
- Houlstone RS. Glutathione S-transferase M1 status and lung cancer risk: A meta-analysis[J]. Cancer Epidemiol Biomark Prev 1999; 8: 675–682.
- Ambrosone CB, Coles BF, Freudenheim JL, et al. Glutathione-S-transferase (GSTM1) genetic polymorphisms do not affect human breast cancer risk, regardless of dietary antioxidants[J]. J Nutr 1999; 129: 565S–568S.
- Curran JE, Weinstein SR, Griffiths LR. Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer susceptibility[J]. Cancer Lett 2000; 153: 113–120. CrossRef
- Smith RA, Curran JE, Weinstein SR, et al. Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer[J]. Breast Cancer Res 2001; 3: 409–411. CrossRef
- Park SK, Yoo KY, Lee SJ, et al. Alcohol consumption, glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk[J]. Pharmacogenetics 2000; 10: 301–309. CrossRef
- Mao GE, Morris G, Lu QY, et al. Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer[J]. Cancer Detect Prev 2004; 28: 368–374. CrossRef
- Nomani H, Ghobadloo SM, Yaghmaei B, et al. Glutathione S-transferases activity in patients with colorectal cancer[J]. Clin Biochem 2005; 38: 621–624. CrossRef
- Prabhu K, Bhat GP. Serum total glutathione-Stransferase levels in oral cancer[J]. J Cancer Res Ther 2007; 3: 167–168. CrossRef
- Sharma A, Tripathi M, Satyam A, et al. Study of antioxidant levels in patients with multiple myeloma[J]. Leuk Lymphoma 2009; 50: 809–815. CrossRef
- Ho JC, Chan-Yeung M, Ho SP, et al. Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma[J]. Eur Respir J 2007; 29: 273–278. CrossRef
- Monari M, Foschi J, Calabrese C, et al. Implications of antioxidant enzymes in human gastric neoplasms[J]. Int J Mol Med 2009; 24: 693–700. CrossRef
- Arsova-Sarafinovska Z, Eken A, Matevska N, et al. Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer[J]. Clin Biochem 2009; 42: 1228–1235. CrossRef
- Kotrikadze N, Alibegashvili M, Zibzibadze M, et al. Activity and content of antioxidant enzymes in prostate tumors[J]. Exp Oncol 2008; 30: 244–247.
- Gokul S, Patil V, Jailkhani R, et al. Oxidantantioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients[J]. Oral Dis 2009; Jul 27 [Epub ahead of print].
- Rajaraman P, Hutchinson A, Rothman N, et al. Oxidative response gene polymorphisms and risk of adult brain tumors[J]. Neuro Oncol 2008; 10: 709–715. CrossRef
- Battisti V, Maders LD, Bagatini MD, et al. Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients[J]. Clin Biochem 2008; 41: 511–518. CrossRef
- Jeon SH, Park JH, Chang SG. Expression of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) in human bladder cancer[J]. Korean J Urol 2007; 48: 921–926. CrossRef
- Onumah OE, Jules GE, Zhao Y, et al. Overexpression of catalase delays G0/G1-to S-phase transition during cell cycle progression in mouse aortic endothelial cells[J]. Free Radic Biol Med 2009, 46: 1658–1667. CrossRef
- Ando T, Mimura K, Johansson CC, et al. Transduction with the antioxidant enzyme catalase protects human t cells against oxidative stress[J]. J Immunol 2008; 181: 8382–8390.
- Liu J, Hinkhouse MM, Sun W, et al. Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype[J]. Hum Gene Ther 2004; 15: 239–250. CrossRef
- Yu J, Kim AK. Effect of taurine on antioxidant enzyme system in B16F10 melanoma cells[J]. Adv Exp Med Biol 2009; 643: 491–499. CrossRef
- Feng X, Zhang L, Zhu H. Comparative anticancer and antioxidant activities of different ingredients of Ginkgo biloba extract (EGb 761)[J]. Planta Med 2009; 75: 792–796. CrossRef
- Title
- Antioxidant enzymes and cancer
- Journal
Chinese Journal of Cancer Research
Volume 22, Issue 2 , pp 87-92
- Cover Date
- 2010-06-01
- 10.1007/s11670-010-0087-7
- Print ISSN
- 1000-9604
- Online ISSN
- 1993-0631
- Publisher
- Chinese Anti-Cancer Association
- Additional Links
- Topics
- Keywords
- Superoxide dismutase
- Catalase
- Glutathione peroxidase
- Glutathione-S-Transferase
- Cancer
- Authors
- Md. Asaduzzaman Khan (1)
- Mousumi Tania (1)
- Dian-zheng Zhang (1) (2)
- Han-chun Chen (1)
- Author Affiliations
- 1. Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, 410013, China
- 2. Department of Biochemistry/Molecular Biology and Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 19131, USA


text:
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You almost sound embarrassed to admit that about Eurovision, Sam?! LOL!!
It does get shown on television even here, and it can sure bring out some eyebrow raisers!
So was that photo taken near where you live? If it is, it's pretty. It feels like my hometown at night. It's along the east coast of Australia so I get to see a lot of street lights shine over the water.


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Wendell Amos
Former long-time resident and a pillar of our community for over 20 years, Wendell Amos, passed away on Monday, November 5, 2012. (see full obituary in the November 9, 2012 edition of the Estes Park News).
There will be a memorial service on Monday, December 17th at 11 a.m. at St. Bartholomew's Episcopal Church, 880 MacGregor Ave., Estes Park with reception following.
In lieu of flowers, donations can be sent to the Estes Valley Land Trust "Wendell and Nancy Amos Fund" P.O. Box 663, Estes Park CO 80517 or Habitat for Humanity, P.O. Box 2745, Estes Park, CO 80517.


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El Paso, TX (KTSM) — Driving to work or across town has been a challenge since Friday night, when a Union Pacific train derailed. The train slammed into a concrete pillar that holds up the I-10 Cotton overpass.
"The number one priority for TxDOT is their safety," said Blanca Del Valle, the spokesperson of TxDOT.
So TxDOT shut down a portion of I-10, leaving three left lanes open for drivers, while closing two right lanes.
"We checked everything to make sure that nothing else was damaged," said Del Valle.
The damaged pillar was eventually removed and Union Pacific replaced it with four steel pillars, until repairs begin Saturday.
"TxDOT is paying for the repairs but we will seek reimbursement from the railroad company. They will put new drill shafts. Then they pour the concrete.The concrete has to be a certain temperature before they can completely cure and then they put the deck top or the cap," said Del Valle.
While TxDOT ensures the project will be complete in 15 days and not a day longer, El Pasoans can count on one thing: heavy traffic and delays.
"Traffic has actually quadrupled.They've actually turned this into a three lane one way instead of a two way shoot," said Fierce Fit Training gym owner Brandon Hollis.
A huge headache for businesses in the area, but for business Brandon Hollis, it's not so bad.
"It's actually eyes on publicity. It's free advertising for us," said Hollis.
With the closure in place on Missouri, traffic is detoured right in front of Hollis' gym.
"Some people actually come in, get information about the gym and sign up," said Hollis.
He's found the silver lining.
"The number of phone calls I've received in the last week probably has doubled since the train derailment," said Hollis.
Repairs on the I-10 overpass begin on Saturday and will last 15 days.


text: 5/28/2013 RZ Mask has announced a partnership with Mossy Oak, and the inaugural products have been revealed to be a trio of new camouflage masks that feature Mossy Oak patterns. Designs are available in Mossy Oak Winter, Duck Blind and Break-Up Infinity. The RZ Mask is a neoprene face mask equipped with an active carbon filter that absorbs its user's exhaled scent. The mask covers the nose and mouth of its user and straps around the back of the neck, offering a comfortable fit. The RZ Mask designed was invented in 2009, and was originally developed to provide a comfortable, filtered solution to prevent the inhalation of dust for its creator as he rode dirt bikes and ATVs. It has remained popular with riders since its release, and is now being offered to hunters. The masks will ship with an MSRP of $34.95. For more information, go to RZMask.com.


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Smart Body Armour?
The lightweight bendable material, known as d3o, can be worn under normal ski clothing. It will provide protection for US and Canadian skiers taking part in slalom and giant slalom races in Turin, Italy. Skiers normally have to wear bulky arm and leg guards to protect themselves from poles placed along the slalom run.
If this works well it will really change the whole action sports scene. Typically body armour is effective but in most cases very annoying and uncomfortable. Something that is less bulky and fits easily under normal active clothing is a real benefit.


text:
The already crowded field of glossy magazines aimed at gay men in South Florida is about to get a new competitor. Muchacho magazine... More >>
After the Canadian snowbirds flew north for the summer, the dailies scaled back their Canada coverage. But even when they were publishing... More >>
The much-ballyhooed video that was secretly shot in the swingers' club Trapeze II was more disappointing than the digitally remastered orgy... More >>
Plantation City Hall hasn't changed much since longtime mayor Frank Veltri left office last month. That's because lobbyists and law partners Bill... More >>
Everybody in this walk-in closet of an editing room at the A.W. Dreyfoos School of the Arts in West Palm Beach is talking at once: Daniel Thomas,... More >>


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Dear Experts,
When we try to customized Splash screen, how can we remove the text of "Copyright SAP AG 2007"?
Thanks in advanced.
Brief answer. I brought this up with SAP early last year and they were going to make it configurable. If it still isn't then the way I fixed this was to modify the par file that contains the copyright text. Note - Make sure you rename the Zpar file appropriately and modify the page layout to use your custom par file if you do this. You'll obviously need to document this for repeatability when you apply support packs but hopefully the config option will be there imminently.
Ps. I can't remember which par file it was but should be pretty obvious. Let us know if you can't find it.
Hi Matt
Have you got the PAR filename handy to modify the Copyright Note?
Thanks a lot
Hi Ankit,
You can modify the Copyright text from umelogonbase.jar as texts are is stored umelogonbase.jar file in PAR file con.sap.runtime.logon.par, you can download from system administration >> suport > portal runtime > browse deployment
Refer to link for more details:
[Modifying The Logon Par(or customising the Logon Screen)|Modifying The Logon Par(or customising the Logon Screen)]
[Modifying The Logon Par(or customising the Logon Screen)---Part2|Modifying The Logon Par(or customising the Logon Screen)---Part2]
Best Regards
Arun Jaiswal
Hi Arun
What you've mentioned is the Copyright note on the portal logon page which normally is something like - © 2008 SAP AG. All rights reserved. And yes this can be changed from umelogonbase.jar which contains the logonLabels_en.properties file.
However, I'm enquiring about the Splash Screen as part of the Ajax FWK Page which has a slightly different copyright notice - Copyright 2007 SAP AG. All Rights Reserved. Is this also updated via the same jar file - I wasnt able to find this string in any of the properties file.
Any thoughts?
Hi Tom,
Did you find any solution to this other than what suggested by MATT.
We also have a same requirement.
We tried modiying the property Copyright Text Display to value None but for some strange reason its not saving. Its still saving the default block.
Edited by: Debasish Sarkar on Aug 30, 2010 3:00 PM


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First day? Welcome!
True or False: You're ready to achieve your higher education and career goals? That's what we thought. And that's what we're here for. From college to career-we've got you covered. So get going! Your future's waiting.
School of Business Administration
Gallagher Business Building (MBU A01)
Missoula, MT 59812-6808
United States
Phone: (406) 243-2064
Fax: (406) 243-2036


text:
This was created by a guy on THR, he wants help to populate it.
Shooting Ranges and Stores
Shows locations of shooting ranges and gun stores. I added a few. This is still a work in progress add some more. You have to sign in before you can add. Wrong info here "Any email address and a password of your choice" you have to get a Google account, sorry. Click on the edit button to add a new one this will bring up tools. Type the address in the search box at top and this will give you a go point.


text:
Hey There Scrappers! Happy Friday!
Warmer weather is on its way and springtime reminds
me of weddings. Anna Designs has two new kits in the
shoppe that are perfect for Spring and Weddings
and if you like customizing your pages and tweaking your own elements,
Anna Designs has some fabulous CU friendly products to help. Can't
you just see the table displays and floral arrangements --
Do you have a little princess to scrap? Just take a peek at
Little Idas Flowers
Here's a bit of whimsy in Spring Garden
Today Anna Designs is sharing a fun
Quick page with us all that coordinates
with her Spring Garden Kit
Click HERE to pick up your copy of Anna's Quick Page
or just head on over to the New Products section of
the shoppe to check it out
Happy Scrapping!


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he seems to have killed an alien by simple heavy use of his power, hence he "asking" his master for help, since he was pretty awesome at that
he seems to have killed an alien by simple heavy use of his power, hence he "asking" his master for help, since he was pretty awesome at that
Where are the true aliens when you need them? How about the vamps?
Spine-rip was instense though.
It looks like Cherry was making that fist he makes when "squishing" hearts. That alien seems to be
going down as well. If I was him I would get my suit on first.
Otherwise, It's cool to see Cherry using his powers, It has been a while since he has done that, as I recall.
He also mentioned Master and that was even greater. Am I being too hopeful too hopeful to wish for a
revival of some of the previous characters? Who would you guys like to see come back?
Izumi and Sakata are the only dead characters I'd like having back. But I assume they won't be coming back
Thinking about the ygun again, its possible the Gantz network is still up to a certain extent even if the guys have walked out their balls... I mean Tokyo Gantz did bring up Kurono2 after he left...
If the Tokyo Gantzers can get to the apartment and figure out the ball they could bring people back... but the only people who could possibly figure this out right now are Reika and Kurono2... possible future plot-point, maybe?
^ Well, it would be just crazy to have hordes of dead gantzers revived again
That´d be cool ^^
I just got the feeling the good guys are going to win this war. Since this is Gantz, mankind being wiped out would be good too. I don't really see why Oku would bring back dead characters now, if anything he might be do a complete wipe out.
etufo: HS is most likely going to die sooner or later. Who will kill the cool character killer?
Popo: well, obviously going by that logic, HS will have to kill himself...


text: Maximize your online presence. clickbooq automatically detects search engine crawlers from Google™, Yahoo! and Bing, and instantly serves them a specially formatted HTML version of your website. This HTML version helps search engines index your website's content more easily, increasing your search relevancy and site rankings. Everything is included: images, thumbnails, titles, captions, and keywords plus all of your Content Page links and website's Meta data (Site Title, Description, and Keywords).


text: NEAR DAYS CREEK, Ore. — The Douglas County Sheriff's Office reports a helicopter crashed into the river near the 13000 block of Tiller Trail Highway near Days Creek. The crash was reported around 11:44 a.m. on Monday. The sheriff's office says emergency personnel responded to the crash site and found a Bell Jet Ranger helicopter … Continue reading »


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David Sirota wrote about the failing public services in New York City due to lack of funding, New York Provides A Snowy Glimpse Into America's Future but leaves out one important issue, it's not an accident.
"Welcome to the New Normal."
Those words should be displayed at New York's airports as a welcome to bedraggled travelers during the Northeast's latest "snowpocalypse." Why? Because the Big Apple's much-lamented paralysis this week is a critical cautionary tale for everyone. As I show in my new newspaper column, the episode warns us about the kind of thing that's likely coming to the rest of America as we now willfully mix three toxic problems.
Those toxic issues are climate change denial, the "conservatives' anti-tax, budget-cutting religion" and plutocracy. All of these are connected and on purpose. It's all part of the bathtub scheme dreamed up by Grover Norquist.
When Government fails due to lack of funding it further puts people in the corner of seeing Government as incompetent and useless. This is a win for the anti-Government party of no. I don't think Democrats ask Republicans who run for office during their campaigns this question enough, "Exactly why do you want to run something you so outwardly despise?"
Progressives see the flawed nature in our Government, the fact that it fails to work for most people, meaning the bottom 95%, is the reason we fight for tougher regulation, campaign finance reform, etc. But the outcome of the last 30 years has brought us regulations that's too complex for most people and perfect for people who can afford legions of lawyers.
This is not an accident.
So those things meant to help people, like plowing the streets during a blizzard can't be counted on anymore. California is a great example of this painful breakdown. As we stare down more massive cuts in basic services, many things that people take for granted may not be as reliable.
This is not an accident.
Living in Southern California I sometimes torture myself with listening to local talk radio hosts John & Ken. They love trashing the State Government, it's like breathing for them. And they love quoting how California is the worst of everything, from taxation to what we spend per prisoner to how much teachers are paid compared to other States. Of course there is no context for their Stats, such as cost of living or when it comes to taxes on Corporations, the many tax loopholes and credits the State gives businesses, which actually brings California to be about average when compared to all fifty States.
Of course the other numbers they leave out are my favorites, like California is 48th when it comes to number of State Workers per capita. State Workers are spread pretty thin with a great deal of work on their plates. It also feeds into this whole Government is inept and can't be efficient meme.
And it's not an accident. Dismantling the greater good and right before our very eyes.
Education is going to be hard hit as well when we can least afford it and just as the reformers are on a rampage to disassemble public education, the great equalizer of our time. Education is what allows anyone become something better. Unions are not the issue (although they certainly haven't helped their cause) and Charter schools are not the solution.
And lastly, the environment, the biggest thing to fail, where all these crisis won't matter one bit if we can't breathe, or have drinkable water (which 1 out of 5 human beings don't have access to as it is, right now).
Of course I wish I had answers. My continued frustration with the Obama Administration has a great deal to do with his inability to turn a mandate into some meaningful reform. I understand that much was accomplished in the last two years but I do believe that more should have been done to help the economy first off, maybe even putting off health care reform in order to push through a much bigger stimulus package.
The middle is a lot bigger than either extreme and I believe that they don't really care who gets shit done, they just want it done. If we had spent more in order get to the economy going right out of the gate, things might be different.
I know it's been said better and more intelligently (Krugman) and by so many others (better and much better know bloggers and journalists), but it's one of those issues that can't be written about enough. It's the shared good that makes our society worthwhile and the idea what we spend our money on shows how we prioritize our values. Dismantling this great good in the name of the tea party, austerity or conservatism not only destroys our very social fabric, it leaves our Country vulnerable to things that are going to be much worse in the next decade or two.
We have to demand that this stop. What are you going to do in the new year to stop the destruction happening before our very eyes?


text:
Kanye West Gives Kim Kardashian a Fashion Makeover [VIDEO]
Would you trust your boyfriend to go through your closet and deliver fashion advice? Kim Kardashian certainly does on this Sunday's "Keeping Up With The Kardashians."
Kim Tells Oprah She's Always Had an 'Attraction' to Kanye West [VIDEO]
Kim enlists the help of Kanye West and his stylist, Renelou Padora, to tackle her closet filled with hundreds of handbags, shoes, and some questionable accessories. "Kanye has inspired me to be more of an individual," Kim proclaims. "I'm excited to collaborate with him to see what his take on fashion is."
Kim Kardashian Says Kanye West Knows 'Everything' [VIDEO]
The closet makeover begins and fans will be able to get another inside look of the Kimye relationship. Sunday's episode will also feature an appearance by Oprah Winfrey, who recently interviewed the entire Kardashian family for her OWN network. It's a jam-packed episode starting at 9 p.m. this Sunday on E!


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(Cross-listed as Biology 331.) Role of the nervous system; sensory and motor mechanism; physiological bases of motivation and emotion; sleep and arousal; and physiological bases of learning, memory, and language. Extensive laboratory training. Work with animals is required. Recommended completion by Fall of senior year for majors.
Psychology 101, Biology 111, Biology 112, or Biology 113/114, and permission of the instructor. (Fall)


text:
Berkeley Public Library
Best Book Clubs In The East Bay
San Francisco is a literary town and it should be no surprise that the Bay Area has a plethora of book clubs for any type of reader. Here are a few in the East Bay that are well established.
East Bay Library Program Taps Into Hidden Job Market
At 13 percent, Oakland's unemployment rate is far above the state and national average but, a series of classes at Oakland and Berkeley's public libraries is helping those looking for work tap into the hidden job market.