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Would you like to get your mail delivered online instead of delivered to a mailbox? If yes, you might want to check out Zumbox for free. Zumbox is a secure service to get your postal mail delivered online.
This is great if you are moving, for travelers, people who have more than one residence, college students, and those who enjoy paying bills online. This is also great for the environment, think of all the paper that will be saved!
You cans start slowly and begin to convert your "snail mail" to email. You decide which companies to receive email from and see if you like it. This may take some getting used to, but if you are an "early adapter", this may be a real time saver for you!
Zumbox $1,000,000 Giveaway – Enter Now and signup for Zumbox, your postal mail online!
Click Here to try Zumbox.
Zumbox is having a huge giveaway with almost $7 million in prizes, including a $1,000,000 prize for one lucky winner. You will be automatically entered just for trying out the free Zumbox service.
From the Zumbox site – What is Zumbox?
"Zumbox is a free service that provides you with a combination digital mailbox and filing system – a Zumbox – based on your street address. They work directly with the mailers that currently send you important mail on paper to deliver exact digital versions of that same mail directly into your Zumbox, where you can view it, set reminders, follow safe links to pay bills, print specific pages and organize an archive of your mail that is available to you forever, for free."
Your opinion matters to me so let me know how you like it.
If you like saving money as much as I do, but don't have the time to search for deals, subscribe for free to get my emails. No spam, no junk, just a great source for today's best deals. If you have a frugal friend or two, share the wealth by spreading the word about MWLT. I get my best tips from my savvy readers!


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quote:I think once I see the Pels play a game, it will be a lot easier.
quote:yes. in fact, i did it today
quote:I agree w/ this... the full concept change still isn't completed yet (meaning new unis/court design/etc)... once the full visuals start rolling out it'll get easier
quote:Is anyone else having trouble adjusting to the name change?

subset: commoncrawl


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In 10 days, we have added an additional 70 members to the Planet. We just hit the 100 mark. Thanks guys for making this your new home.
In 10 days, we have added an additional 70 members to the Planet. We just hit the 100 mark. Thanks guys for making this your new home.
So who's #100?Originally Posted by ShawnMedGuy
Well it says SteelHeel but I don't believe that to be accurate...I'm fairly sure we have added 2 since him.
FWIW, SteelHeel was #99 earlier this morning (I checked after he was posting last night...), but now #100... So there is some lag in it somewhere... I don't know how, because they all are in a time/date order...Originally Posted by ShawnMedGuy
I don't remember seeing moondoggie89 in there earlier.
He was #98 last night.... seriously.Originally Posted by NKySteeler
2013 MNF Executive Champion!
Team Needs, 2015 Draft (In order of need): CB, NT, OLB, FS, DE
This is creepy. ARe you guys STALKING Steelheel??Originally Posted by SteelerOfDeVille
Cleveland spelled backwards is DNA Level C
another AA/AS original.
Maybe we're stuck in a time-loop like on Lost.
props to the sigmaster,AsianSteel.
....You know, Les, Jimmy Buffett has a theory about that as well......Originally Posted by Les 74
Do any of his theories involve a bong??Originally Posted by NKySteeler
props to the sigmaster,AsianSteel.


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by trevisan2 » 22 Aug 2012, 03:58
by Tessa78 » 22 Aug 2012, 05:09
\trevisan2 wrote:I can not seem to locate a place called Ono Degno, Brescia
Can someone tell me what the proper name of this Comune or Frazione is?
Ono Degno, comune of Pertica Bassa - province: Brescia - region: Lombardy
ALSO ANOTHER place in Brescia is Sedezano, Brescia?
Closest frazione name I could find to Sedezano...
Sedena, comune of Lonato - province: Brescia - region: Lombardy
Thank You in advance,
by trevisan2 » 22 Aug 2012, 07:40
Users browsing this forum: 2paz and 1 guest


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St. John the Divine, Upper West Side
Upper West Side
New York City
Tel: 212 316 7540
Concierge.com's insider take:
Affectionately known as "St. John the Unfinished" by inhabitants of its Morningside Heights neighborhood, the world's largest Gothic cathedral has staunchly remained under construction since the laying of its cornerstone in 1892. Construction was already slated to continue for decades when a 2001 fire forced yet another halt. The cathedral's cavernous navethe length of a football fieldwill be closed until late June 2008 while cleaners scrub soot off its stones. Later in the summer, visitors will gain access to previously concealed attractions such as the Great Rose Window (a 40-foot stained-glass masterpiece); the Poets' Corner (which honors America's literary elite); and 13 other themed bays saluting pursuits both religious and secular. In turn, the east end choir and chapel will close for the reinstallation of the Great Organ, whose 8,035 smoke-damaged pipes were removed for cleaning: November 30, 2008, will see the grand reopening of the entire interior, when regular concerts will resume there. Outside, on the grounds, you'll find live peacocks and the Peace Fountain, a bizarre sculptural piece depicting an animal version of Armageddon that includes giraffes, a smiling sun and moon, an enormous crab, and a decapitated Satan. On the first Sunday in October, St. John's holds its annual Blessing of the Animals in recognition of St. Francis's feast day. Tours are held Tuesday through Sunday. Call to inquire about the Vertical Tour, to take in heavenly views accessed by a hellish climb up and down an 11-story circular staircase.
Tours Tuesdays through Saturdays at 11 am and 1 pm, Sundays at 2 pm.


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With eight dealerships located across Queensland and New South Wales, Black Toyota is the only place to shop for your pre-owned vehicle. The group has an extensive range of quality (over 200), late model passenger & commercial vehicles, (utes, 4x4's) at competive prices. Black Toyota is sure to have the perfect car to suit your indvidual needs. If not, we will do our best to find a vehicle for you.
Black Toyota offers:


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NVIDIA Provides Physics Technology For PS3
NVIDIA Provides Physics Technology For PLAYSTATION®3
SANTA CLARA, CA-MARCH 17, 2009-NVIDIA Corporation today announced that it has signed a tools and middleware license agreement for PLAYSTATION®3 (PS3) with Sony Computer Entertainment Inc (SCEI). As a result, the binary version of the NVIDIA® PhysX® technology software development kit (SDK) is now available to registered PS3 developers for free download and use on the SCEI Developer Network.
The NVIDIA PhysX technology software development kit SDK consists of a full-featured API and robust physics engine, designed to give developers, animators, level designers, and artists unprecedented creative control over character and object physical interactions by allowing them to author and preview physics effects in real time. The continued adoption of NVIDIA PhysX technology by the world's leading content developers is resulting in games that not only look as realistic as possible, but also provides gaming experiences where the world's literally come to life: environments become highly interactive with effects such as persistent debris, including shattered glass and weapons ammunition, trees that bend in the wind, and water that flows with body and force.
"NVIDIA is proud to support PLAYSTATION 3 as an approved middleware provider," said Tony Tamasi, senior vice president of content and technology at NVIDIA. "Games developed for the PLAYSTATION 3 using PhysX technology offer a more realistic and lifelike interaction between the games characters and other objects within the game. We look forward to the new games that will redefine reality for a new generation of gamers."
The PhysX technology source code SDK for PS3 and all major gaming platforms are available for license directly from NVIDIA. For more information on licensing PhysX SDKs or NVIDIA PhysX technology, please visit: http://www.nvidia.com/physx.
About NVIDIA
NVIDIA (NASDAQ: NVDA) is the world leader in visual computing technologies and the inventor of the GPU, a high-performance processor which generates breathtaking, interactive graphics on workstations, personal computers, game consoles, and mobile devices. NVIDIA serves the entertainment and consumer market with its GeForce® products, the professional design and visualization market with its Quadro® products, and the high-performance computing market with its Tesla products. NVIDIA is headquartered in Santa Clara, Calif. and has offices throughout Asia, Europe, and the Americas. For more information, visit http://www.nvidia.com.
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The quantity of ton-miles is the product of the tonnage of a shipment times the miles the shipment traveled to its destination. The quantity of value-miles is the product of the declared value of a shipment times the miles the shipment traveled. Both ton-miles and value-miles are derived from separate estimates of either weight or value and miles traveled.
Ton-mile and value-mile figures are combined from separate estimates of export and import trade traffic for a variety of categories. Despite growing attention to measures of tonnage, miles, and value, both ton-mile and value-mile estimates have many substantial sources of error. Because the data sources are not designed to directly yield ton-mile and value-mile measures, the estimates require application of model-based estimation techniques that rely on unvalidated assumptions. The models that were used in the BTS study included the Oak Ridge National Laboratory's (ORNL) highway network model to derive estimates of the distances traveled by imports and exports. The accuracy of the distance estimates from this model is unknown. Moreover, data on imports were available only at the state level. The accuracy of the assumptions used to distribute state-level imports to counties within a state is unknown because of a lack of data at the substate level, and substate level allocations are needed to determine the likely route taken, which provides a better assessment of the miles traveled within a state.
Moreover, the various data sources utilized to produce estimates of international ton-miles and value-miles transported by highway have known and unknown errors and biases that affect the accuracy and reliability of the estimates. The errors and biases are due not only to typical sources, including sampling variance, nonresponse variance, and measurement error of various types, but also to various data deficiencies, even though the models mentioned above are used to overcome these deficiencies.
The BTS study identified a number of sources of error for a variety of data sets used to estimate volumes and values for freight arriving here as imports or departing as exports, which we summarize below. In addition, there are shipments involving Canada and Mexico that are not straightforward exports or imports: truck shipments between Canada and Mexico and shipments to or from the United States that are transshipped via Canada or Mexico are not fully captured in current trade data for all modes of transportation, which is also a source of error. Also, some truck transportation was not included in the estimates of the amount of international trade because no reliable data were available, especially including drayage, or short-haul shipments.


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January 13, 2006
- December 11, 2006
- November 6, 2006
- October 30, 2006
- October 25, 2006
- October 23, 2006
- September 19, 2006
- September 11, 2006
- August 21, 2006
- August 11, 2006
- August 7, 2006
- July 31, 2006
- July 18, 2006
- June 30, 2006
- June 27, 2006
- May 10, 2006
- May 2, 2006
- April 21, 2006
- April 10, 2006
- March 21, 2006
- March 10, 2006
- February 27, 2006
- February 9, 2006
January 13, 2006
CMS Issues Policy on Dealing with Medicare UpdateLast week, Herb Kuhn, Director for Medicare Management at the Centers for Medicare and Medicaid Services (CMS), sent a letter to Congress outlining how CMS anticipates dealing with the Medicare update factor for 2006.
As you know, because Congress failed to enact legislation in 2005 to fix the Medicare update factor for 2006, physician payments were cut by 4.4 percent starting January 1, 2006.
However, it is expected that Congress will pass legislation in early 2006 that will mandate a 0.0 percent update for Medicare in 2006.
In the letter to Congress, Mr. Kuhn indicated that CMS would be able to process claims at the 0.0 percent update starting two business days after enactment of the legislation. Further, Mr. Kuhn indicated that CMS will not require physicians to resubmit claims that have already been processed to receive the revised payment rate. Medicare carriers and fiscal intermediaries will automatically reprocess these claims and make the 4.4 percent adjustment. The letter outlined that, pending swift enactment of the legislation, CMS hopes to have all the claims reprocessed by July 2006 and expects to provide physicians with lump sum payment checks reflecting the revised payment rate.
Additionally, CMS will reopen the Medicare provider participation period for 2006. The enrollment period will run for an additional 45 day after enactment of the legislation. Any physician that elects to change their status to "participating� will have that status made retroactively to January 1, 2006.
NHLBI Set to Make Changes to Deal with FY06 Budget ShortfallOn January 4, ATS staff met with Dr. Elizabeth Nabel, Director of the National Heart, Lung and Blood Institute (NHLBI) as part of the annual meeting arranged by the NHBLI Constituency Group. The NHBLI Constituency Group is a coalition of organizations that support the NHBLI, of which the ATS is a member. Dr. Nabel gave an overview of the research successes and activities that NHLBI did in fiscal year 2005 (FY05), programs in FY06 and research opportunities for FY07.
Dr. Nabel outlined steps the Institute would take to adjust to the cut in the fiscal year 2006 budget, including
- Non-competing awards cut 2.35% below FY06 Notice of Grant Award amount. Amounts indicated in future budget periods also will be adjusted by the same factor
- Competing renewals will be capped at a 3% increase over the previous budget
- Intramural research will be cut by 1% below FY 2006 budget level
- The amount budgeted for contracts and Centers is being reduced by at least 1%
Dr. Nabel discussed how decreasing funding has impacted the research payline at NHLBI. At the conclusion of the NIH doubling effort, the NHLBI payline was at the 21st percentile. Currently the payline is at the 14th percentile and likely to drop in fiscal year 2006.
HHS Release Pandemic Flu Guide
On January 6, the Department of Health and Human Service released a guide to help to inform and prepare Americans for a pandemic flu epidemic. According to HHS Secretary Mike Leavitt, the Pandemic Influenza Planning: A Guide for Individuals and Families is "a new tool to help Americans understand the threat of pandemic influenza and specific actions they can take to protect themselves and their families.�
The handbook includes a "Pandemic Flu Planning Checklist for Individuals and Families" and "Family Emergency Health Information Sheet" to help people gather information and resources they may need.
A copy of the "Pandemic Influenza Planning: A Guide for Individuals and Families," other checklists and pandemic planning information are available online at www.pandemicflu.gov.
Points of Contact
Gary Ewart | Senior Director, Government Relations |
Nuala Moore | Senior Legislative Representative |
Joe Kirby | DC Office Administrator |


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Who will face the press in Monte Carlo this weekend?
As is tradition, the opening press conference in Monaco is a day earlier than usual on Wednesday and features, among others, past race winners David Coulthard and Olivier Panis. As usual, Formula1.com will bring you full transcripts of every conference.
Wednesday May 19, 1500 local time (1300 GMT):
David Coulthard (McLaren) and Mark Webber (Jaguar), then from 1530, Rubens Barrichello (Ferrari), Olivier Panis (Toyota) and Jarno Trulli (Renault).
Thursday May 20, 1600 local time (1400 GMT):
Mike Gascoyne (Toyota), Patrick Head (Williams), Adrian Newey (McLaren) and Pat Symonds (Renault).
Saturdays and Sundays conference will take place immediately after qualifying and the race respectively, with both featuring the top three drivers.


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Event Name
- OR - Select an option belowhttp://www.paragontheaters.com/showtime/paragon-deerfield-8/ This 8 screen theater offers a full service bar and lounge call The LOT. There is stadium seating in all theaters as well as Diamond Reserved Seating available only in the PepsiMax 50' Extreme Theater. 3-D films are also available. More >>
http://phoenixtheatres.com This 15-screen cinema offers Dolby Digital sound, comfy stadium seating, and a selection of 3D films. More >>


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Resort Stripe Outdoor Area Rug
Love it!
This rug feels wonderful on my bare feet. The weave will be durable enough to keep my Weimaraner kids from picking it us. Also, I love the fact that I can hose it off after pollen season. I may have to buy another one for the other porch.
August 28, 2014
Love it
This has replace my previous rug that was also bought from Frontgate years ago. It has updated my black wicker patio set. I bought the largest rug(black/cream)when it had free shipping....otherwise the rug would have cost too much. Wait for free s/h.........
July 17, 2014
Quality purchase
Great quality for an outdoor carpet. Color is perfect, always happy with my Frontgate purchases.
July 8, 2014
Nice rug
Rug was a little pricey; however, it had good color and works wells outside; dries quickly
July 8, 2014
a nice little rug
I should have measured more carefully because the rug I ordered is much too small for the space I want it to cover. It's a nice rug but does not really compliment the two porch rugs I purchased from Frontgate a few years ago that are no longer available so I cannot match a smaller rug with them.
July 1, 2014
Gorgeous Outdoor Rug!
This rug exceeded my expectations - the white is a subdued white not an "in your face white"- which I think is much more suited for the outdoors. Excellent quality and have received many compliments!
June 28, 2014
Nice rug -- color lighter than shown on photo
Am pleased with this rug -- looks good on my back patio; however the green color is not as bright as shown on the photo
June 26, 2014
Great quality and great looking rug
i ordered this in the black and white, and it is so bold and perfect for my otherwise blah space. the sizing options are great-the second to largest size is perfect for under a table and chairs. with a sale and a coupon, this was a great buy.
June 13, 2014
(5 Questions : 5 Answers)
Product Q&A
Get help about this item from fellow customers. Ask your questions. Share your answers.
Resort Stripe Outdoor Area Rug
1 answer
How well has the color held up when used over time in direct sun?
I am interested in the green stripe.
1 week, 2 days ago
The Resort Stripe Outdoor Area Rug is UV stabilized to minimize fading.6 days ago
Resort Stripe Outdoor Area Rug
1 answer
Are all of your outdoor rugs made from the same materials?
I put my outdoor rug on my deck - where it is exposed to elements, rain, sun, etc. Last year I had an "outdoor rug" that had some natural fibers in it - and we had small bugs that would make their home there (resulting in small bites on bare feet!) I want to be certain that the outdoor rug I buy is the best for resisting mold or other problems resulting from moisture. Can you make a recommendation? I think a plasticky-weave would be best - but I'm not sure about polypropelyne? What that is, and how well it does with exposure to elements?
10 months ago
Polypropylene is going to be the most durable and stain. mold, and mildew resistant option.9 months ago
Resort Stripe Outdoor Area Rug
1 answer
what other color is in the black stripe
10 months ago
Thank you for your interest in the Resort Stripe Outdoor Area Rug. There are no colors in the rug besides black and the natural colored fiber between the stripes.10 months ago
10 months ago
The Resort Stripe Outdoor Area Rug is not reversible and we do recommend a rug mat or pad to provide additional cushioning and to help keep the rug in place.10 months ago
Resort Stripe Outdoor Area Rug
1 answer
green stripe rug
in the catalog and in the picture with the sofa the rug looks like a lighter green, but when I click on the icon with the colors it looks darker, can you tell me if its more on the lighter side or darker
11 months ago
The resort Stripe Outdoor Area rug comes in a ligh/medium shade of green11 months ago
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Product:68618-Resort Stripe Outdoor Area Rug


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Since starting Filmmaking Stuff, many screenwriters have written me, asking if I could provide advice on how they can protect their screenplay from theft. I usually tell screenwriters that most producers will not go through the process of raising a gazillion dollars without compensating the screenwriter fairly.
Filmmaker David Allen Talks Modern Moviemaking and VOD Distribution
Earlier this week, I caught wind of an indie production company based in Australia called Rapidfire Productions. This is a production company that operates as a self sustaining modern moviemaking business. They develop movies, get money, make their movies and through their own distribution arm, the company reaches the masses.
Filmmaker Jason Brubaker Gets Punched Out By LA Producers Over Video On Demand Sales Projections
When I published my article on leveraging VOD sales to finance your movie, I had no idea that a simple internet marketing formula for filmmakers would be such a polarizing issue. I can't tell you how many Los Angeles based movie producers responded negatively through email. One guy even told me my grammar sucked.
Filmmaking through Toxic Soup
A few years back, while flying aboard a loud propeller driven airplane somewhere over the snow capped mountains of Colorado, I heard the guy in front of me talking to his girlfriend about an idea for a movie. Since I had just finished production on my second feature, I felt compelled to chime in. And […]
How To Find Investors For Your Movie
If you ever wondered how to get money to make your movie, you're not alone. As filmmakers, many of us would rather focus on our filmmaking – And if we had it our way, we would save the go-get-movie-money for a producer.


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Description of Partner 34D Telephone
The Partner 34D Telephone is a speaker display phone with 32 programmable buttons for line or feature appearances.Features
- 32 programmable buttons with dual LEDs for line or feature appearances
- 2 line x 24 character backlit tilt display
- Built-in conference, transfer, hold, and speaker buttons
- Full duplex speakerphone for hands free operation
- Built-in port allows for connection of standard devices, such as modems or fax machines
- Ideal for programming and operator position
- Compatible with Partner, Partner Plus, and Partner II systems. Release 3.0 and higher. Compatible with all Partner ACS releases
- One Year Warranty
Free UPS Ground shipping on orders of $500+. Within Continental U.S. (under $500 orders only $9.95)
A portion of each purchase will be donated to The Penrickton Center for Blind Children.
For more information, visit penrickton.com
Have Telecom Items For Sale?
Top Dollar Offered - Lightning Fast Bids Provided firstname.lastname@example.com


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Sepsis-induced cardiomyopathy: a review of pathophysiologic mechanisms
- Anthony Flynn,
- Bhalaghuru Chokkalingam Mani,
- Paul J. Mather
- … show all 3 hide
Rent the article at a discount
Rent now* Final gross prices may vary according to local VAT.
Get AccessAbstract
Cardiac dysfunction is a well-recognized complication of severe sepsis and septic shock. Cardiac dysfunction in sepsis is characterized by ventricular dilatation, reduction in ejection fraction and reduced contractility. Initially, cardiac dysfunction was considered to occur only during the "hypodynamic" phase of shock. But we now know that it occurs very early in sepsis even during the "hyperdynamic" phase of septic shock. Circulating blood-borne factors were suspected to be involved in the evolution of sepsis induced cardiomyopathy, but it is not until recently that the cellular and molecular events are being targeted by researchers in a quest to understand this enigmatic process. Septic cardiomyopathy has been the subject of investigation for nearly half a century now and yet controversies exist in understanding it's pathophysiology. Here, we discuss our understanding of the pathogenesis of septic cardiomyopathy and the complex roles played by nitric oxide, mitochondrial dysfunction, complements and cytokines.
- Hoesel LM, Niederbichler AD, Ward PA (2007) Complement-mediated molecular events in sepsis leading to heart failure. Mol Immunol 44:95–102 CrossRef
- Hunter JD, Doddi M (2010) Sepsis and the heart. Br J Anaesth 104:3–11 CrossRef
- Weisel RD, Vito L, Dennis RC, Hechtman HB (1977) Myocardial depression during sepsis. Am J Surg 133:512–521 CrossRef
- Court O, Kumar A, Parillo JE, Kumar A (2002) Clinical review: myocardial depression in sepsis and septic shock. Critical Care 6:500–508 CrossRef
- Parker MM, Suffredini AF, Natanson C, Ognibene FP, Shelhamer JH, Parrillo JE (1989) Responses of left ventricular function in survivors and nonsurvivors of septic shock. J Crit Care 4:19–25 CrossRef
- Parker MM, Shelhamer JH, Bacharach SL et al (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Int Med 100:483–490
- Raeburn CD, Sheppard F, Barsness KA, Arya J, Harken AH (2002) Cytokines for surgeons. Am J Surg 183:268–273 CrossRef
- Stein B, Frank P, Schmitz W, Scholz H, Thoenes M (1996) Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase. J Mol Cell Cardiol 28:1631–1639 CrossRef
- Pathan N, Hemingway CA, Alizadeh AA, Stephens AC, Boldrick JC, Oragui EE, McCabe C, Welch SB, Whitney A, O'Gara P, Nadel S, Relman DA, Harding SE, Levin M (2004) Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet 363:203–209 CrossRef
- Malhotra R, Edelman ER, Lilly LS (2003) "Basic cardiac structure and function". Pathophysiology of heart disease: a collaborative project of medical students and faculty. Lippincott Williams &Wilkins, Ed. Leonard Lilly. Philadelphia, PA, pp 10–26
- Rudiger A, Singer M (2007) Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med 35(6):1599–1608 CrossRef
- Gulick T, Pieper SJ, Murphy MA et al (1991) A new method for assessment of cultured cardiac myocyte contractility detects immune factor-mediated inhibition of β-adrenergic responses. Circulation 84:313–321
- Hare JM, Colucci WS (1995) Role of nitric oxide in the regulation of myocardial function. Prog Cardiovasc Dis 38:155–166 CrossRef
- Balligand J-L, Ungureanu D, Kelly RA et al (1993) Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest 91:2314–2319 CrossRef
- Chung MK, Gulick TS, Rotondo RE et al (1990) Mechanism of cytokine inhibition of β-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction. Circ Res 67:753–763
- Zanotti-Cavazzoni SL, Hollenberg SM (2009) Cardiac dysfunction in severe sepsis and septic shock. Curr Opin Crit Care 15(5):392–397 CrossRef
- Kinugawa K, Takahashi T, Kohmoto O, Yao A, Aoyagi T, Monomura S, Hirata Y, Serizawa T (1994) Nitric oxide-mediated effects of IL-6 on [Ca2+]i and cell contraction in cultured chick ventricular myocytes. Circ Res 75:285–295
- Muller-Werdan U, Schumann H, Fuchs R, Reithmann C, Loppnow H, Koch S, Zimny-Arndt U, He C, Darmer D, Jungblut J, Stadler J, Holtz J, Werdan K (1997) Tumor necrosis factor α is cardiodepressant in pathophysiologically relevant concentrations without inducing nitric oxide synthase or triggering serious cytotoxicity. J Mol Cell Cardiol 29:2915–2923 CrossRef
- Saraiva RM, Hare JM (2006) Nitric oxide signaling in the cardiovascular system: implications for heart failure. Curr Opin Cardiol 21:221–228 CrossRef
- Xu L, Eu JP, Meissner G, Stamler JS (1998) Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 279:234–237 CrossRef
- Zimmet JM, Hare JM (2006) Nitroso-redox interactions in the cardiovascular system. Circulation 114:1531–1544 CrossRef
- Bendall JK, Cave AC, Heymes C, Gall N, Shah AM (2002) Pivotal role of a gp91 (phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice. Circulation 105:293–296 CrossRef
- Butler R, Morris AD, Belch JJ, Hill A, Struthers AD (2000) Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension 35:746–751
- Guthikonda S, Sinkey C, Barenz T, Haynes WG (2003) Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers. Circulation 107:416–421 CrossRef
- Wu LL, Ji Y, Dong LW, Liu MS (2001) Calcium uptake by the sarcoplasmic reticulum is impaired during the hypodynamic phase of sepsis in the rat heart. Shock 15:49–55 CrossRef
- Chen HW, Hsu C, Lu TS, Wang SJ, Yang RC (2003) Heat shock pretreatment prevents cardiac mitochondrial dysfunction during sepsis. Shock 20:274–279 CrossRef
- Stuart RA, Cyr DM, Neupert W (1994) Hsp70 in mitochondrial biogenesis: from chaperoning nascent polypeptide chains to facilitation of protein degradation. Experientia 50:1002–1011 CrossRef
- Mizzen LA, Kabiling AN, Welch WJ (1991) The two mammalian mitochondrial stress proteins, grp 75 and hsp 58, transiently interact with newly-synthesized mitochondrial proteins. Cell Regul 2:165–179
- Hewett JA, Schultze AE, VanCise S, Roth RA (1992) Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab Invest 66:347–361
- Tsuji C, Minhaz MU, Shioya S, Fukahori M, Tanigaki T, Nakazawa H (1998) The importance of polymorphonuclear leukocytes in lipopolysaccharide-induced superoxide anion production and lung injury: ex vivo observation in rat lungs. Lung 176:1–13 CrossRef
- Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Harken AH, Meng X (2002) ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol 283:R477–R486
- Niederbichler AD, Hoesel LM, Westfall MV, Gao H, Ipaktchi KR, Sun L, Zetoune FS, Su GL, Arbabi S, Sarma JV, Wang SC, Hemmila MR, Ward PA (2006) An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med 203:53–61 CrossRef
- Gu M, Bose R, Bose D, Yang J, Li X, Light RB, Mink S (1998) Tumor necrosis factor-alpha but not septic plasma depresses cardiac myofilament contraction. Can J Anesth 45:280–286 CrossRef
- Hosenpud JD, Campbell SM, Mendelson DJ (1989) Interleukin-1 induced myocardial depression in an isolated beating heart preparation. J Heart Transplant 8:460–464
- Vincent JL, Bakker J, Marecaux G, Schandene L, Kahn RJ, Dupont E (1992) Administration of anti-TNF antibody improves left ventricular function in septic shock patients: results of a pilot study. Chest 101:810–815 CrossRef
- Opal SM, Fisher CJ Jr, Dhainaut JF, Vincent JL, Brase R, Lowry SF, Sadoff JC, Slotman GJ, Levy H, Balk RA, Shelly MP, Pribble JP, Labrecque JF, Lookabaugh J, Donovan H, Dubin H, Baughman R, Norman J, DeMaria E, Matzel K, Abraham E, Seneff M (1997) Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double blind, placebo-controlled multicenter trial. The interleukin-1 receptor antagonist sepsis investigator group. Crit Care Med 25:1115–1124 CrossRef
- Carlson DL, Willis MS, White J, Horton JW, Giroir BP (2005) Tumor necrosis factor-α-induced caspase activation mediates endotoxin-related cardiac dysfunction. Crit Care Med 33:1021–1028 CrossRef
- Grocott-Mason RM, Shah AM (1998) Cardiac dysfunction in sepsis: new theories and clinical implications. Intensive Care Med 24:286–295 CrossRef
- Watson D, Grover R, Anzueto A, Lorente J, Smithies M, Bellomo R, Guntupalli K, Grossman S, Donaldson J, Le Gall JR (2004) Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: Results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med 32(1):13–20 CrossRef
- Lopez A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, Brockway M, Anzueto A, Holzapfel L, Breen D, Silverman MS, Takala J, Donaldson J, Arneson C, Grove G, Grossman S, Grover R (2004) Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock*. Crit Care Med 32(1):21–30 CrossRef
- Levy RJ, Deutschman CS (2004) Evaluating myocardial depression in sepsis. Shock 22:1–10 CrossRef
- Title
- Sepsis-induced cardiomyopathy: a review of pathophysiologic mechanisms
- Journal
Heart Failure Reviews
Volume 15, Issue 6 , pp 605-611
- Cover Date
- 2010-11-01
- 10.1007/s10741-010-9176-4
- Print ISSN
- 1382-4147
- Online ISSN
- 1573-7322
- Publisher
- Springer US
- Additional Links
- Topics
- Keywords
- Cardiomyopathy
- Sepsis
- Nitric oxide
- Complements
- Cytokine
- Myocardial depression
- Industry Sectors
- Authors
- Anthony Flynn (1)
- Bhalaghuru Chokkalingam Mani (2)
- Paul J. Mather (3)
- Author Affiliations
- 1. Cardiology, St. Louis University Hospital, 3635 Vista Ave. 13th Floor, St. Louis, MO, 63110, USA
- 2. Department of Medicine, Thomas Jefferson University Hospital, 803 College Building, 1025 Walnut Street, Philadelphia, PA, 19107, USA
- 3. Department of Medicine, Advanced Heart Failure and Cardiac Transplant Center at the Jefferson Heart Institute, Jefferson Medical College of Thomas Jefferson University, 925 Chestnut Street, Suite 323 A, Philadelphia, PA, 19107, USA


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Ann Albers
Ann Albers is a popular spiritual instructor, angel communicator, lecturer, and author. She is a traditional Reiki master and a modern mystic who delights in distilling ancient wisdom into practical, down-to-earth tools for modern living.
Ann's passion and purpose is teaching others to tap into the power and beauty of their souls, as well as helping people connect with the love and wisdom of their angels. She guides people to live in the eternal flow of Divine Grace and to gracefully manage the flow of energies in their own lives, bodies, and emotions.
Past Shows:
Seeress of Prevorst, Angels & Mediums
Biophysicist with an interest in the ancient worlds, Dr. John DeSalvo discussed his research into the Seeress of Prevorst, a 19th century German mystic and clairvoyant who wrote and spoke in what she called "the language of the spirits." This could have been the original language of mankind, first used by angels, DeSalvo proposed. He noted the language's alphabet has certain similarities to diagrams Jesse Marcel Sr. made of designs on the Roswell I-beams, and the symbols abductee Betty Hill drew under hypnosis, suggesting to him a possible ET connection.Though her convulsions and trances kept her bedridden, the Seeress was able to diagnose and recommend remedies for others, and predict the near future. ... More »
Host: George NooryAngelic Communications
Angel communicator Ann Albers discussed mystical dimensions, evolved spiritual beings, and demonic entities.Angels are like the nerve signals of the universe, and can be thought of as frequency beings, she said. Demons, in contrast, are disconnected from the field, and consciously and maliciously seek to foster negative emotions. A good way to disengage from demons is to not indulge or react to them, so they have nothing to feed on, she explained. Albers said she is able to send her consciousness into other dimensions, which are spheres of awareness. The frequency of the angelic realm is like a beautiful symphony, with a swirling mass of color, she detailed, adding that she regularly receives guidance from a variety of angelic presences. The angels convey that humans have access to the same information or source that they do, and must learn to put as much trust in themselves as they do in them, she shared. Intention is important in developing the ability to communicate with ange ... More »
Host: George Noory


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Harrah's New Orleans Hotel brings you the best shows, concerts and entertainment.
Don't miss Sinbad live at Harrah's Theater on Saturday, March 21! Two shows at 7 p.m. and 9:30 p.m.
Don't miss the Ultimate Abba Tribute when ABBAcadabra comes to Harrah's New Orleans on April 18.
Joint's Jumpin' will rattle your soul, shake your shimmy and take you back to those good old days! Don't miss this celebration of Classic New Orleans Rhythm & Blues at Harrah's Theatre on Friday, March 20, at 8pm.
Don't miss Australia's Thunder From Down Under at Harrah's Theater on May 29th and 30th!
Travel back to the 60's at Harrah's New Orleans with Shadows of the 60's June 6th at Harrah's Theater!


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StartUpHire is the place to find Mobile jobs in and near Woburn. Review the list below of Mobile Woburn jobs. These Mobile jobs represent some of the most rewarding careers available. You can refine your job search for Mobile jobs in Woburn by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options. Don't see the employment opportunity you're looking for? Check back soon for more Mobile jobs in Woburn, or sign up for an email alert (link in upper left) to receive periodic updates on new Mobile jobs in Woburn, MA.
The Pre-sales Solutions Consultant at MuleSoft actively drives and manages the technology evaluation stage of the sales process and is an integral member of the Sales team, working as the key technical advisor and advocate for our products. In order to be successful in this role,
1/16/2015 Boston, MA Save This JobYour role: Xamarin, created by developers, wants to build the best and most pleasant developer tools to create mobile applications. The Xamarin Platform allows developers to build native iOS, Android, Mac applications in C# that complement Microsoft?s C# offerings on Windows.
3/3/2015 Boston, MA Save This JobYour Job: As a Xamarin Developer Evangelist you'll be responsible for spreading the word about Xamarin to developers around the world, online and in person. Xamarin is growing FAST and needs social coders to help us reach and enable even more developers to build successful iOS
2/1/2015 Boston, MA Save This JobYour Role: Xamarin, created by developers, knows what developers want: a modern programming language, powerful tools, an efficient and delightful workflow and the power to create the best user experiences. The Xamarin Platform allows developers to build native iOS, Android, Mac
3/3/2015 Boston, MA Save This JobYour Role: As a Customer Support Engineer, you?ll be the first point of contact with Xamarin?s customers. You?ll work closely with product engineers and guide customers from a potential problem to a successful solution, delighting customers in the process. This remote position
2/1/2015 Boston, MA Save This JobYour Role: Xamarin is looking for a talented Systems Engineer with excellent problem-solving and communication skills to join our internal IT team, assisting our Boston office, as well as the rest of our staff around the world. The IT Team is responsible for internal IT
3/3/2015 Boston, MA Save This JobYour Role: The Lead Software QA Engineer will work closely with the development team to assess test scope for new features, identify testability issues, and write tests. They will regularly relay quality assessments during development and release to the QA manager and
2/1/2015 Boston, MA Save This JobYour Role: The Xamarin Studio Lead Software QA Engineer will work closely with the Xamarin Studio development team to assess test scope for new features, identify testability issues, and write tests. They will regularly relay quality assessments during development and release to
2/1/2015 Boston, MA Save This JobModo Labs is looking for an organized, smart, and creative person to join our team as a Senior Service Delivery Manager. This is a highly visible front-line role where you can learn a ton about mobile and help make a real difference every day for our great customers. Part
1/31/2015 Cambridge, MA Save This JobResponsible for providing product-focused support in the sales process and maintaining strong relationships with existing customers to increase technical sales. Responsibilities: ? Work directly with prospects and customers to answer their questions and identify their mobile
2/23/2015 Waltham, MA Save This JobDepartment: Technology Location: Providence, RI Type: Full-time, Salaried, Exempt Are you interested in joining a team of dedicated testers? Looking to work at a fast-paced, dynamic software-as-a-service company providing a positive, healthy solution to our end-users? Both our
1/11/2015 Providence, RI Save This JobField Applications Engineer - Eastern Region (Boston, New York, Virginia etc...) The Ayla Platform? is the industry?s only complete end-to-end solution for transforming everyday products into cloud-connected devices quickly, easily and economically. Ayla combines its innovative
2/12/2015 Boston, MA Save This JobToday, Zipcar provides hundreds of thousands of people with a viable alternative to traditional car ownership, saving them money, time and headaches. Around the world?from coast to coast, across Canada, the UK, and college campuses in between?people are making the decision to
2/1/2015 Boston, MA Save This JobDescription EyeNetra seeks a Lead Product Manager to oversee and drive a product portfolio that will change the face of mobile health. You will work closely with the co-founders to push out all hardware, mobile and web components of our product. This role requires big-picture,
1/25/2015 Somerville, MA Save This Job**This position is based in our Washington, DC HQ. We are offering a relocation subsidy. If you are open to relocation, please read on!**You know LivingSocial as the marketplace to buy and share the best things to do in your city and beyond. And while we're bringing excitement
1/17/2015 Boston, MA Save This JobEngineering Boston, MA, United States Today, Zipcar provides hundreds of thousands of people with a viable alternative to traditional car ownership, saving them money, time and headaches. Around the world?from coast to coast, across Canada, the UK, and college campuses in
3/3/2015 Boston, MA Save This JobDo you want to interact with our growing global community of 40 million fitness enthusiasts? Join our Community Team and engage with our users while working side-by-side with internal teams to improve the RunKeeper experience. We are looking for someone who welcomes the challenge
2/26/2015 Boston, MA Save This JobCambridge, Massachusetts Job Description Job description We're looking for a copywriter to join our Engagement Communications team. PatientsLikeMe is a patient network and real time research platform. We?re focused on improving the lives of people who are living with disease,
2/24/2015 Cambridge, MA Save This JobJob ID: 16144 Job Location: Waltham MA About the Job This role is for a talented and practiced User Experience Design Manager who is passionate about building dynamic interfaces and experiences that are both engaging and usable, and that is capable of managing and mentoring a
2/17/2015 Waltham, MA Save This JobPosition Description One of Aegerion?s core strengths is leveraging its global workforce to quickly identify and execute innovative strategies and solutions. This innovation benefits the patients we serve and enables our broader success in the marketplace. Collaboration is a
2/13/2015 Cambridge, MA Save This Job


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Free backing tracks & online jams. Free Loops Samples Acapellas Vocals Downloads Royalty Free Music. Patchwork - Online modular sound synthesis. Laboratory Archive 2000-2010. Online Drum Machine. Isle of Tune. ♫ Tony-b Machine ♫ Otomata - Online Generative Musical Sequencer.
If you like Otomata, check out my new instrument Circuli by clicking here! Update: Click here to get Otomata for your iPhone / iPod / iPad! Official facebook page: Inudge.net - Nudge. Theremin - A Playable Touch Synthesizer Using Web Audio API. ✖Update: 7 February 2014 Thanks to everyone for sharing!
Over 100,000 people have played on the theremin in the last 3 days which is absolutely amazing. Due to a large number of requests, we've began working on a record function as well as an offline version of the app which will be available soon. Feel free to either subscribe at the bottom of the page or follow us on Facebook & Twitter for updates and future toys. Seaquence. ButtonBass Make Music online. Play the Virtual Piano With Your Keyboard. Incredibox. AudioSauna - Free Music Software - Make Music Online.
How to Play Maple Leaf Rag By Scott Joplin. Get inspired by Beck's. Soundation — Make music online. PRO GUITAR TUITION. METRONOME ONLINE - free! Free printable staff paper @ Blank Sheet Music .net. Free Blank Guitar Tab and Chord Diagrams. Monkey Machine - online drum machine. Create Music Beats - The online music factory - Jam, remix, chords, loops. BallDroppings. Play The Armonica. To play the armonica below, click on a glass bowl.
Like the real armonica, the tone will linger as you click on the next bowl, putting tones together to make a melody. Now try playing armonica music using a more familiar keyboard. Below are some simple melodies to try. Mary Had a Little Lamb: E D C D E E E rest D D D rest E E E rest E D C D E E E E D D E D C hold. Drumbot. André Michelle - Laboratory. Beatlab. Let's get started making music... 1draw on the grid with your mouse to make a beatshow me2 save your track and share it with friends. show me3 out of ideas?
Roll the dice and start remixing. show me4 explore the beatlab community show me For more tips, tutorials vidoes, and FAQs, check out our community wiki. You can use the following keyboard shortcuts while composing a track. spacebar. Audiotool.


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Competition News & Issues
Equine Pharmacology, Therapeutics, and Toxicology
Find out the reasons why competition horses might test positive for certain drugs and substances
Photo by Anne M. Eberhardt/The Horse
Apply with Caution: Is Your Topical Treatment Show-Safe?
Some topicals contain illegal substances that could result in a medication disqualification at your next show.
Horse Racing Medication Regulations Reviewed
Medication regulations for racehorses are changing. Here's what you need to know.
Photo by Anne M. Eberhardt/The Horse
More Articles
- Florida Senate to Discuss Uniform Racehorse Medication Bill
- Anabolic Steroids Still an Issue in U.S. Horse Racing
- OBS Adopting Model Medication Rules
- RCI: Same Mission, New Approach on Medication
- RCI Has New Take on Out-of-Competition Tests
- Stewards: Australian Yearling Not Positive for Steroids
- British Racehorse Steroid Policy Has U.S. Ramifications
- Maryland Thoroughbred Trainers Cited for Compounded Drug Use
- Ohio Begins Examining Racehorse Medication Rules
- Racehorse Health, Welfare Covered at New York Meeting
Farm Call: Your Questions Answered
Q. I was wondering how many days phenylbutazone (Bute) can stay in a horse's system? I have a horse which has to stay on this medication on a fairly constant basis. Carole If you mean how long is the drug effective at reducing inflammation or how long can it be detected in serum or urine, the answers are different. Also, dosage is a significant factor, as
Horse Sense (and Sensibility)
14 More Considerations for Preventing Horse Barn Fires
What steps have you taken to prevent fires in your barn? What challenges must you overcome to help your barn be more fireproof?


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Complete solutions. Complete success.
The following projects showcase just a few successful building envelope solutions from Firestone Building
Products. To see additional profiles, visit our online portfolio.
310th Air Space Wing
Colorado Springs, CO
The construction of the new 310th Space Wing Headquarters in Colorado Springs, CO, required a long-term, maintenance-free facility. As such, the facility would provide a clean, well-maintained environment that subscribes to the Schriever Air Force Base Green Energy Efficiency policy. The 28,000 sq. ft. facility features the Series 1200 Wall Panel System in Alucobond 4-mm covering 10,887 sq. ft. and UNA-CLAD™ champagne metallic UC-6 Roofing Panels (22-gauge prefinished steel) covering 462 sq. ft., to create the clean look the building owner requested. SBS UltraWhite™ modified bitumen cap sheet and membrane provides the heat reflectivity to save energy costs and meet the facility's Green Energy Efficiency policy.
Brigestone Americas Technical Center
Akron, OH
The Bridgestone Americas Technical Center was built to LEED® Gold specification. The roof of the 265,000 sq. ft. facility is composed of two layers of 2″ Firestone ISO 95+ GL mechanically attached insulation, one layer of ½" Firestone ISOGARD™ HD Coverboard, Firestone fully adhered 90-mil RubberGard™ EcoWhite™ Platinum™ EPDM backed by a 30-year Firestone Platinum™ Warranty, and topped with SkyScape™ Vegetative Roof System, SkyPaver™ Walkways and vegetative roofing. Additionally, the building features many Firestone Metal Wall components such as: S4500 Aluminum Panel Rainscreen System, Flat Lock Stainless Steel Wall Panels, UC-600 Aluminum Exposed Fastener Panels and more.
Central DuPage Hospital Convenient Care Center
Glen Ellyn, IL
The new Central DuPage Hospital Convenient Care Center features 13,000 sq. ft. of fully adhered 60-mil Firestone UltraPly™ TPO. The Glen Ellyn, IL, medical center also features 900 sq. ft. of Firestone Series 1000UC composite wall panels, 2,900 sq. ft. of Firestone UC-500 flush soffit panel system, and 3,400 sq. ft.of 24-gauge prefinished steel 7.2-inch corrugated custom-fabricated herringbone panels.
University of Minnesota TCF Bank Stadium
Minneapolis, MN
When the University of Minnesota (UM) decided to build a new football facility, school officials wanted to construct a "green" venue. Due to a city-based campus and limited green space, the primary challenge was creating a sustainable and durable stormwater solution. After researching viable options for the project, the university selected the Environmental Passive Irrigation Chamber (EPIC Chamber™ System) from Firestone. The system collects rainwater and runoff, filters pollutants and slows the rate of water flow into the nearby Mississippi River.
Firestone Building Envelope Solutions
Firestone Water Management Solutions
Green Options from Firestone
Firestone Red Shield Metal Wall Panel Certified Contractor Program
2012 Sustainability Report
Roots to Rooftops App
RoofGenuity Roof Model Tool
Technical Information
Firestone Project Portfolio


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Ingredients & Description
Humans naturally produce this hormone in the adrenal glands. Through the process of aging, our body's ability to maintain production diminishes. Low levels of DHEA can contribute to feelings of depression, fatigue, and may also slow one's metabolism.Modern day research suggests that DHEA may even help reverse certain effects of aging. In some cases, decreases in bone loss, a healthier immune system, and an increase in energy levels have been attributed to the taking of DHEA. Regular levels of this hormone can help regulate mood and enable the body to better handle stress.
Each Capsule Contains:
DHEA (dehydroepiandrosterone) | 25 mg |
Other ingredients: Gelatin (capsule), rice powder. |
*Not intended to diagnose or treat diseases or ailments, and is not reviewed by the FDA.
Uses & Indications.