text:
Heatwave scowled at the TV. "Why are we watching this? That guy's as cranky as Kade!"
Blades and Chase looked at each other, but Boulder frowned. "Aww, I thought you two were getting along better?"
"We were until that dog bit him. Then he started acting like a jerk again."
Chase grabbed the remote and tapped the mute button. "I suspect that being bitten by potentially rabid creatures is quite unpleasant for human beings."
"But that doesn't explain why he grew a beard." Blades chirped, leaning in.
Heatwave shrugged. "I don't know. It's colder in the autumn, maybe. And maybe he's trying to be like his dad."
"Hmm… Crankiness… hair growth… is he eating different things?"
"I don't know. Maybe."
Chase frowned. "Blades, surely you are not suggesting—?"
"Heatwave, is he still being a glory hog, or is he a different kind of cranky?"
Heatwave replayed the last month in his head. He shuddered, realizing Kade's mugging for the camera had virtually stopped. Most of the whining had been about Heatwave's driving; something about the rabies vaccine for the bite causing nausea. "No, he's just angry and sick all the time."
"He's a werewolf," Blades announced.
"Werewolves are a stupid human myth."
Chase briefly checked the listing on the movie before changing the channel. "I suppose werewolves are most likely fictional, or else our allies would have provided countermeasures. For that matter, human scientific literature and non-fiction media would discuss the topic with the certainty they apply to the existence of extraterrestrials."
Heatwave rolled his optics. "Where did you learn sarcasm?"
"Cody taught me." He paused, adding, "While I agree that lycanthropy is unlikely, we appear just as fanciful by human standards of proof. It bears further research and concern."
Boulder nodded. "I'm with him there. Any change in our human partners is something we should talk to them about."
"Fine, I'll ask him how he's feeling," Heatwave scoffed. "But he's not a monster. Werewolves aren't real."
"Neither are alien robots," scolded a voice from behind them, and Heatwave fought the urge to jump.
"Chief Burns," Chase asked, "Surely every being that appears in human fiction does not exist in fact?"
"No, but I bet werewolf myths were based you guys." Chief Burns approached, grinning under his moustache. "I don't think you're responsible for Devil's night, though."
"I don't like the sound of that."
"It's tonight, the night before Halloween," Burns explained. "It's a time of mass pranks. In the Midwest, it means arson. And we have four new families from Detroit in town this year."
"So what do we do?" Heatwave asked.
"You and Kade will patrol for fires." The chief frowned. "Take it easy on him; he's not feeling well. But tell him to shave that beard. It might break the seal on his mask."
Heatwave scowled, nodded, and headed off to find his partner.
He found the redhead waiting at the door. Kade's skin seemed paler than ever, especially in contrast to that red goatee. Heatwave had gotten used to seeing a sallow face, but even going on a month's growth, the beard was a shock.
"Hey Dr. Morocco, Ready to fight some fires?"
"Hey, that monster had a moustache." Kade puffed out his chest. "This is a goatee."
"Yeah, and your dad says it'll wreck your mask." Heatwave transformed, body folding into a fire truck on the concrete. He opened his door, and Kade climbed in, digging at his upholstery with sharp nails.
"I tested it," Kade snapped as he buckled his seatbelt. "He needs to lay off. And hey, no sudden stops tonight."
"Another rabies shot?"
"No, Dani's cooking, maybe."
Heatwave started his engine and rolled out the door. "So I guess you won't be cleaning grease stains off my floor."
"I dunno, eating might help. I kinda want chow mein. Besides," Kade grumbled, rolling his eyes, "If you'd just keep a garbage bag in here I wouldn't throw anything on your floor."
"You want me to keep your garbage inside my body?" He grumbled, steering toward a bump for spite. "That's sick, Kade."
The bump hurt, but Heatwave waited to see Kade squirm. Instead the human gasped and retched, a look of terror sweeping over his face as one hand flew to his mouth.
"What's wrong with you? Do I have to drive, you stupid hunk of metal?"
"I'm worried about my passenger. How can we fight fires if you can't move without spewing out your intake?"
"I can keep it together if you drive better!" Kade crossed his arms and looked out the driver's side window. He shuddered, looking down.
Heatwave scanned the input from his mirror cameras on that side for any threats, but found only the full moon. "Whatever."
"And what's up with you? You're never nice to me."
"I have a bad feeling about this."
"It's nothing. Calm your bits."
They drove in silence for a while before Kade demanded they stop for food. At first it went well, Kade nibbling at wax-wrapped beef and noodles, but after a few minutes of eating, the human demanded Heatwave stop "somewhere with a bathroom." Heatwave complied. As Kade staggered into the Hall of Inspiration, Heatwave tried not to think too hard.
He had hardly parked when Chief Burns radioed in. "Heatwave, is everything all right? Kade isn't responding to my calls."
"No. He had to stop at the Hall of Inspiration," Heatwave explained.
"Leave him there; we've got a fire in the warehouse where we impounded Morocco's inventions."
"What about our cover?"
"I'll tell everyone that Cody's operating you remotely. Now hurry; corner of LaMarche and Burton. And call Cody; have him ask Doc to pick up Kade!"
Heatwave turned on his sirens and took off.
"Cody, I had to leave Kade at the Hall of Inspiration on the way to a fire," Heatwave shouted into a different channel.
"Got it, I'll ask Doc Greene to pick Kade up." Cody shouted back. "Who's driving?"
"You are. Remotely."
"OK. Should we pick Kade up now?"
Heatwave braked hard at the thought. "No! I… I don't think he's done in there yet. Besides, you and I need to talk."
"Why? What'd I do?"
"What kind of movies are you showing my team?"
The boy chuckled nervously. "No, history, promise. Just some spooky Halloween fun."
"You have Blades convinced Kade is a werewolf!" Heatwave flinched inwardly, regretting his volume.
"Oh, because the dog bite? Don't worry about it." Cody chuckled. "He doesn't fit the signs."
"I'm not worried about it. They're worried about it."
"Oh, I know." He thought he heard Cody stifle a giggle. "So what's this about a fire?"
"It's the warehouse where we put Morrocco's inventions," Heatwave explained. "Why set a fire there?"
"I don't know why we're storing all that stuff there anyway," Cody asked. "Having anything that guy worked on near the power plant is a mistake."
"Not burning anything that guy made to the ground is a mistake," The flames came into view, burning building shadowed by the hill. "I'm there, Cody. Go pick up Kade."
The blaze poured out the windows as if trying to escape itself. Chase stood before the fire, wincing, clutching the Chief Burns in his metal hands.
"Heatwave! Evan's still in there!" Chief Burns stared up at him with dark eyes, and the sight of him squirming stopped Heatwave in his tracks. "The arsonist is still inside!"
"Heatwave! You must not go!" Chase ordered. "The internal temperature of the fire is high enough to melt the nanofuel containers we confiscated from Dr. Morocco!"
He shook his head, scowling, walking for the blaze. "Then it'll melt the thief, too."
He tore the door from its hinges and stepped inside.
It had only been months since Morocco's competition, but it seemed like vorns since he'd fought a fire that hot. The smoke taunted him with the threat of clogged intakes and overheating. Still, it felt familiar. Heatwave knew how to deal with fires.
He shouted "Hello?" at the top of his voice, trying to sound like Kade. Heatwave wondered if his gruff timbre would fuel the werewolf rumors when the arsonist recounted the night, but he tried to drop the thought. No movie monsters. No Kade. Just rescuing.
A wordless scream struck him, truncated by a cough.
He ran toward it, shouting, "I'm coming!"
He ran past every piece of equipment they'd taken from Morocco, hoping that Chase was wrong about the temperature. Every bump underfoot made terror seize his spark. It only took seconds to reach his target, but that gave him plenty of time to wonder if his worries about Kade were misplaced. That nanofuel might make him the monster.
Still, the real villain huddled near a window, waiting. Dark eyes rimmed by sooty glasses looked up at Heatwave, and he recognized the arsonist: Evan, the mute thief from the haunting heist.
"You!" Heatwave snarled, approaching Evan. He noticed something shiny in the boy's hands, but dismissed it quickly, focused on grabbing the thief.
Evan screamed, scrambling to his feet and running away; Heatwave nearly fell as he changed direction to follow him.
"Wait! I'm here to help!"
The boy wailed, the canister in his hands glinting in the firelight. Heatwave almost froze when he realized what it was, but pushed onward. He shuddered as they moved on, fans working overtime as he followed into warmer territory.
A cough interrupted the boy's cries.
Heatwave started to believe they might both escape as they approached a small door in the back. He had just begun to slow when Evan screamed and darted away from the egress. The door rattled, indentations appearing near the top of it, followed by an angry howl.
He froze in his tracks, terror washing over him. It was really true. Blades was right. Kade was…
Evan shrieked and dashed toward the flames, brandishing the canister in his hand. Heatwave found himself sure it held the nanofuel that nearly killed Boulder, but he chased after anyway, hoping the werewolf at the door was on his side.
The boy approached the heart of the flames, and Heatwave grunted, his tires starting to reek of burnt rubber. Evan noticed it too, running back toward Heatwave. The Rescue Bot stooped to grab him, but Evan slipped between his fingers, canister tapping Heatwave's thumb with a twang.
Heatwave spun on his heels to grab Evan. The boy screamed, clawing at the air as he spun back toward Heatwave. Evan ran straight into Heatwave's palm, and the Autobot imagined holding Cody to keep his grip gentle. As he turned his attention toward the door, the lubricants ran cold in his lines in spite of the heat.
A mask lay on the floor.
A fire mask.
Kade's mask.
He heard a tiny roar from his hands, and Heatwave looked down to see Evan slam the red-branded canister on his fingers. A shiny swarm began to snake up his arm. Heatwave tried to brush it away with his other hand, but it flowed around his fingers. He felt the nanofuel swarm in his intakes, burning in a way the fire never could. His circuits surged, commands overwriting his intentions, limbs moving without him. He flailed, desperate to regain control, even if only of his fingers. When his back hit the floor with a clang, Heatwave's hand finally popped open. He heard Evan scream as he fled.
Heatwave stared at the yellow moon as his body, unbidden, climbed to its feet.
He struggled to keep composure as the nanofuel ravaged his circuits, pulling him toward the exit. He wanted to find the boy, but he knew he'd have a hard time turning his head.
But turn his head he did, just in time to see something scramble out the back doorway. The door lay on the ground, splintered, long slashes running down it. The mask still lay there by it, untouched. Panic crept in. Kade…
Then his head jerked the other way, eyes scanning for something without him. He struggled to remember what they'd had Boulder do when the nanofuel had jumped into him, but it had been out of his control. They'd steered him toward the power plant, Heatwave remembered, and suddenly he understood why Charlie had picked this warehouse to store Morocco's things.
He had nothing but time to dwell on it as his body tore through the fire, the smell of burning rubber lighting up his sensors with distress. Still, that was nothing compared to the searing pain in his executive circuits. He resolved not to fight, to save his strength for when he needed it, and that took the edge off the burning as he watched his body navigate the warehouse without him. Was that how Kade felt now? Was Kade…
Was Kade still in the building?
He fought through the fog around his circuitry, trying to activate his radio. It seemed to take forever, but eventually he opened a channel. "Chief! Report!"
"We have Evan!"
"What about Kade?"
"He's out, but Dani doesn't know where he went!"
"I can't go looking for him," Heatwave pleaded. He started to explain, but Charlie interrupted.
"I saw the canister. Get to the power plant. We'll look for Kade."
He burst out of the loading bay, roaring in anguish; Chase approached, wary. For a moment, he felt the nanofuel disengaging with his circuits, as if it were considering his teammate. By the time smaller robot frowned with pity, the grip on his body tightened. Of course. The nanofuel needed the largest machine.
The scene passed by him, burning into his memory like the fire in his lines. The chief, the thief, and Dani stood there, looking up slack-jawed in the firelight. Dani and the thief looked worried, but Chief Burns' eyes shined too much in the firelight. Heatwave remembered that Kade was Charlie's son, and that let him manage a frown.
Then he looked up, toward the hill, his feelings as confused as his controls.
A wolf stood there on the hill… or maybe something like a wolf, bur larger, rusty brown in the fiery glow. It stared at him with dark eyes.
He ran toward the beast, momentarily surprised that the nanofuel gave no complaints as his body obeyed him. Only when his eyes moved without his consent did he realize why: behind the wolf he knew was Kade lay the power plant.
The wolf took off toward the plant with a howl, and Heatwave panicked as he felt his targeting systems activating. For the first time in his life, he silently thanked Primus that he had no weapons. His arm shot off, firing its first impotent burst of water. The wolf dodged nimbly as mud flew up behind it, picking up speed toward the plant.
The second burst hit, and Heatwave screamed "Kade!" as it did,
The wolf stopped a moment to shake off, tail starting to wag. It turned back toward him and let an excited bark before running onward. The third burst of water hit the walls of the power plant; the wolf had disappeared from sight.
As his arms tore the power plant door from its hinges, and his legs stormed in, Heatwave felt relief with the burning. As the nanofuel left him, his last thought was one of gratitude. Maybe Kade being a monster wasn't so bad as long as the jerk were still in there.
The next thing Heatwave knew, something hairy scratched at his shoulder. "Stupid hunk of metal. Wake up and be ok already…"
He sat up, letting a little cry of shock at the sight of his partner.
The human sat near him, red beard even wilder than before. Bandages rather than fur decorated his pale, bare arms. Hands, feet, face…
"Kade… but you…."
"Had it completely under control." The human grinned wide. "Good thing I got sick at the Hall. I was just in time to hunt Myles down. Evan was just a distraction."
Heatwave tried not to think about Myles' fate. "But what about…"
"The nanofuel? Chase was wrong; it didn't melt. Evan just opened it."
Heatwave growled. "You're not listening to me! What about your mask?"
"Beard ruined the seal; I'll shave tomorrow, after I finish my costume."
"And why were you at the warehouse?"
"Graham had it under control. You needed me."
Heatwave hesitated. "And the wolf I followed?"
"Ok, ok. That was me."
The rage that swept over Heatwave burned; for a second, he thought he might still have nanofuel to purge. He roared, "You're a werewolf and you didn't tell me?"
The human fell over at that, laughing, pounding the ground with hairless hands.
"You're so gullible! You fell for that?"
"I'm not gullible!" Heatwave roared. "I saw a wolf! And… and Blades said!"
"People can't turn into monsters."
"My people turn into cars!"
Kade finally sat up, wiping tears from his eyes. "That was a hologram, like Myles used before? Graham used it to lure you up to the power plant." He shook his head. "You know I'd tell you if something were going on with me, right?"
"You don't talk about feelings!"
"Whoah, whoah! I don't talk about emotions. Anything that's gonna get in the way of my job, I tell you about. Like tonight. If you don't believe me, call dad. Ask him about the holograms."
The Autobot grumbled and activated his radio, broadcasting so Kade could hear. "Chief, what's this about a wolf hologram?"
"What? Graham and Myles never got the holograms working."
Heatwave growled. "What? So what was the wolf?"
"Not a clue."
"We have to find it!"
"No we don't." Kade sighed, scratching his beard. "We're going back to base to pick Blades' brain, no matter how dumb we look."
Relief filled Heatwave's circuits. "At least I'm an alien who turns into a truck. I have two excuses."


text: E-DRUG: NEJM: The Neurontin legacy ---------------------------------- [Warning: Long posting. Copied as fair use] The New England Journal of Medicine this week carries a perspective article on what has become 'the Neurontin case'. Neurontin is Pfizers gabapentin product. It has been heavily marketed for non-approved indications (off-label prescription). The story came to light as a former employee sued Pfizer for its marketing. It is rare to have marketing tactics so detailed documented, all documents (8 000!) have become publicly available and can be accessed by all (link in article). http://content.nejm.org/cgi/content/full/360/2/103 Landefeld CS, Steinman MA. The Neurontin Legacy Marketing through Misinformation and Manipulation. 2009; 360: 103-6 (8 January) Old drugs usually fade away. Sometimes, however, they leave surprising legacies. In 1997, for example, a study comparing the effects of brand-name and generic formulations of levothyroxine led to an uproar over the discovery that the manufacturer of the brand-name product suppressed publication of the result that the two formulations were equivalent. Recently, lawsuits alleging damages from illegal marketing of another old drug, gabapentin (Neurontin), have yielded remarkable discoveries about the structure and function of pharmaceutical marketing. Patented in 1977 and approved by the Food and Drug Administration (FDA) in 1993 in doses of up to 1800 mg per day as adjunctive therapy for partial complex seizures, Neurontin became a surprise blockbuster for ParkeDavis, a division of WarnerLambert, which was purchased by Pfizer in 2000. U.S. sales rose from $98 million in 1995 to nearly $3 billion in 2004 before Neurontin faced generic competition and lost most U.S. sales. The rise of Neurontin would have been unheralded except for a quirk of fate: a young biologist, David Franklin, went to work for ParkeDavis on April 1, 1996. Fresh out of postdoctoral training at Harvard, Franklin soon grew concerned that he was participating in illegal marketing. At a training seminar for "medical liaisons" on April 16, 1996, Franklin and his peers were told that FDA regulations required a fair and balanced presentation and prohibited promotion of a drug for off-label uses, selling by medical liaisons, and soliciting of inquiries from physicians. Six days later, a ParkeDavis executive reportedly told Franklin, I want you out there every day selling Neurontin. . . . We all know Neurontin's not growing for adjunctive therapy, besides that's not where the money is. Pain management, now that's money. Monotherapy [for epilepsy], that's money. . . . We can't wait for [physicians] to ask, we need [to] get out there and tell them up front. Dinner programs, CME programs, consultantships all work great but don't forget the one-on-one. That's where we need to be, holding their hand and whispering in their ear, Neurontin for pain, Neurontin for monotherapy, Neurontin for bipolar, Neurontin for everything. I don't want to see a single patient coming off Neurontin before they've been up to at least 4800 mg/day. I don't want to hear that safety crap either, have you tried Neurontin, every one of you should take one just to see there is nothing, it's a great drug.1 Three months later, Franklin left ParkeDavis and filed a suit (ultimately, United States of America ex rel. David Franklin vs. Pfizer, Inc., and Parke-Davis Division of Warner-Lambert Company) alleging that off-label marketing of Neurontin constituted "false claims" designed to elicit payments from the federal government. On May 13, 2004, WarnerLambert agreed to plead guilty and to pay more than $430 million to resolve criminal charges and civil liabilities. A class-action suit was filed the next day in federal court on behalf of private parties who had paid for illegally marketed Neurontin; this case (now known as In Re: Neurontin Marketing, Sales Practices, and Products Liability Litigation) remains active. The Franklin case placed more than 8000 pages of corporate documents in the public domain; these documents are now available in a searchable digital library at the University of California, San Francisco (www.dida.library.ucsf.edu). The class-action suit also generated detailed testimony and reports that are available through the Federal Judiciary's Public Access to Court Electronic Records Service Center (e.g., https://ecf.mad.uscourts.gov/doc1/09502786849). The Neurontin cases have revealed the mechanisms of action of a comprehensive marketing campaign its goals and strategies, tactics and programs, and the participation of particular physicians and institutions.2 The campaign involved the systematic use of deception and misinformation to create a biased evidence base and manipulate physicians' beliefs and prescribing behaviors. These marketing methods were not found to be illegal in themselves; they were illegal insofar as they promoted off-label prescription. Thus, the importance of the cases lies largely in the light they shed on marketing methods that may be widespread but remain unseen because companies are rarely prosecuted for illegal marketing. The Neurontin marketing plan consisted of both general strategies such as the promotion of Neurontin use among high-prescribing physicians and cultivation of thought leaders and tactical programs.2 Local physicians were recruited, trained, and paid to serve as speakers in "peer-to-peer selling" programs, which the company saw as "one of the most effective ways to communicate our message." Academic leaders were solicited with educational grants, research grants, and speaking opportunities; some received up to $158,250 over a 4-year period. Advisory boards and "consultants" were convened so that the firm could cultivate relationships with them and deliver "a hard-hitting message about Neurontin." Marketing "tactics" included education, publications, and research whose promotional intent was disguised, in addition to more transparent activities, such as advertising and sales visits.2 "Educational programs" reflected the belief that "medical education drives this market!" Teleconferences involving practicing physicians were moderated by physicians who were paid as much as $176,100 over 4 years. ParkeDavis formed speakers bureaus and sought "strong Neurontin advocates and users to speak locally for Neurontin." "Unrestricted educational grants" were made to for-profit medical-education companies that produced programs to discuss unapproved uses of Neurontin and to grant credit approved by the Accreditation Council for Continuing Medical Education. A "publication strategy" was designed to increase the use of Neurontin for neuropathic pain and bipolar disorder, off-label indications with great revenue potential. ParkeDavis contracted with medical-education companies to produce articles on prespecified topics, target journals, titles, potential authors to be "chosen at the discretion of ParkeDavis," and "a consistent message" in keeping with promotional goals; some articles were ghost-written. "Research" was designed and commissioned specifically to promote Neurontin use. A large seeding trial was conducted to "teach physicians to titrate Neurontin to clinical effect" and "to give neurologists the opportunity to titrate to higher doses [up to twice the FDA-approved limit] when needed." In a recently unsealed 318-page analysis of research sponsored by ParkeDavis, epidemiologist Kay Dickersin concluded that available documents demonstrate "a remarkable assemblage of evidence of reporting biases that amount to outright deception of the biomedical community, and suppression of scientific truth concerning the effectiveness of Neurontin for migraine, bipolar disorders, and pain."3 For example, publication was delayed for a report on a multicenter, placebo-controlled study that found no effect of Neurontin on the primary outcome measure for neuropathic pain because "we [ParkeDavis employees] should take care not to publish anything that damages neurontin's marketing success." Ultimately, ghost-written manuscripts downplayed the lack of effect on the primary outcome and emphasized other outcomes and subgroup analyses that favored Neurontin. Although guest authorship and commercial bias in research are a well-recognized threat to scientific integrity, the documentation of comprehensive manipulation of research and publication related to Neurontin is remarkable. What is Neurontin's legacy? First, we have learned that pharmaceutical marketing can be comprehensive, strategic, well financed, disguised as "education" and "research," influential, and very effective. Promotion of Neurontin was neither discrete, compartmentalized, nor readily apparent; instead, it was intercalated in nearly every aspect of physicians' professional lives, from the accoutrements of practice to lectures, professional meetings, and publications. Although some pharmaceutical marketing may be less opaque, deceptive, and manipulative, evidence indicates that drug promotion can corrupt the science, teaching, and practice of medicine.4 Second, such comprehensive marketing involved many people and institutions that apparently failed to recognize the serious ethical and legal problems with their actions. Employees of ParkeDavis, the medical-education companies it hired, and many physicians (consultants, advisors, educators, and researchers) all participated knowingly. Universities, hospitals, professional organizations, and foundations also participated, and oversight agencies such as the FDA and the Department of Justice did not intervene quickly. Apparently, there was a shared acceptance that ParkeDavis's marketing was simply business as usual. Finally, these cases substantiate the emerging conviction that "drastic action is essential" to preserve the integrity of medical science and practice and to justify public trust.4 We believe that such action should include the routine placement of legally discovered documents in the public domain, the study of such documents to inform strategies for minimizing abuses, the establishment of penalties that eliminate the profit to be gained through illegal marketing, and the independent public funding of peer-reviewed pharmaceutical research through a National Institute for Pharmaceutical Research that might be funded by a tax on all drug sales.5 Will our profession soon feel compelled to advocate for such actions to preserve our integrity, our social contract, and ultimately our privileges? Neurontin's most important legacy may be promoting our discussion of these issues and perhaps pushing us beyond the tipping point to action. Drs. Landefeld and Steinman report serving as unpaid consultants to the plaintiff's attorney in United States of America ex rel. David Franklin vs. Pfizer, Inc., and Parke-Davis Division of Warner-Lambert Company and participating in the creation of the Drug Industry Document Archive by the University of California, San Francisco, Kalmanovitz Library, an effort that was funded in part by Thomas Greene, whose law firm represented David Franklin in the case. Dr. Steinman also reports receiving support from an educational grant funded by the Attorney General Settlement Fund that arose from the Franklin case. No other potential conflict of interest relevant to this article was reported. The views expressed in this article are those of the authors and do not necessarily reflect the official views of the Department of Veterans Affairs. Source Information Dr. Landefeld is a professor of medicine and chief of the Division of Geriatrics at the University of California, San Francisco (UCSF), San Francisco; associate chief of staff for geriatrics and extended care at the San Francisco Veterans Affairs Medical Center (SFVAMC), San Francisco; and a fellow at the Center for Advanced Study in the Behavioral Sciences, Stanford University, Stanford, CA. Dr. Steinman is an assistant professor of medicine at UCSF and a staff physician at SFVAMC. References 1. Disclosure of information by relator David P. Franklin pursuant to 31 U.S.C. 3730 b(2), page 11. (Accessed December 16, 2008, at http://dida.library.ucsf.edu/pdf/rab00a10.) 2. Steinman MA, Bero LA, Chren MM, Landefeld CS. The promotion of gabapentin: an analysis of internal industry documents. Ann Intern Med 2006;145:284-293. [Free Full Text] 3. Dickersin K. Reporting and other biases in studies of Neurontin for migraine, psychiatric/bipolar disorders, nociceptive pain, and neuropathic pain. August 10, 2008. (Accessed December 16, 2008, at http://www.pharmalot.com/wp-content/uploads/2008/10/neurontin-dickersin-2.pdf.) 4. DeAngelis CD, Fontanarosa PB. Impugning the integrity of medical science: the adverse effects of industry influence. JAMA 2008;299:1833-1835. [Free Full Text] 5. Landefeld CS. Commercial support and bias in pharmaceutical research. Am J Med 2004;117:876-878.

subset: commoncrawl


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Our family tree include the following surnames: My husband's side of the tree; Pennington, Dodd, Beach, Calloway, Jenkins, Lemon, Barclay and Waldrop. My side of the tree; Johnson, Barret, Johnston, McKenzie, Hughes, Hindman, Smith, McDonald, Stokes,and Rucker. Research is ongoing and queries are welcomed. Welcome to those who are seriously researching any of the Surnames listed above. Contact by Email: firstname.lastname@example.com |
The Jackie Lee Pennington's family of Dallas, TX
Updated February 1, 2004 |
Jeanene Johnson Pennington 7730 Indian Springs Rd. Dallas, TX 75248 United States (972) 233-1260 firstname.lastname@example.com |
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Oregon Ducks running back Kenjon Barner runs for a touchdown in the first quarter against the Arkansas State Red Wolves at Autzen Stadium. Oregon won 57-34.
Krystle Marie Reyes, 25, of Salem, Ore., pleaded guilty Tuesday and was sentenced to 5 1/2 years in prison for fraudently claiming and receiving a $2.1 million tax refund. Wednesday, four Oregon tax workers were disciplined.
Oregon''s Kelsey Chambers gets a hit against Tennessee during the Women''s College World Series on Saturday. Oregon won 3-1.
The Simpsons in their bomb shelter, unaware of what the citizens of Springfield were planning for them in the 500th episode the show on Feb. 19. After years of speculation about the which state hosts the hometown, Matt Groening has revealed to Smithsonian magazine that it''s the Springfield in Oregon, south of Portland.
Oregon wide receiver Lavasier Tuinei runs for a first downl past UCLA safety Stan McKay during the third quarter of the Pac-12 Championship game at Autzen Stadium in Eugene, Ore.
USC running back Marc Tyler gains a first yard during the Trojans 38-35 upset over No. 4 Oregon.
USC running back Marc Tyler gains a first down during the Trojans 38-35 upset over No. 4 Oregon.
Oregon running back LaMichael James celebrates one of this three touchdowns against Stanford on Saturday.
Oregon Ducks running back LaMichael James celebrates a first down against the Stanford Cardinal at Stanford Stadium. The Ducks defeated the Cardinal 53-30.
Oregon running back Kenjon Barner celebrates with teammates after scoring a touchdown in the third quarter Saturday.
For two centuries, farmers and fun seekers have celebrated county fairs with carnival games, livestock shows and local food. Next year marks the 200th anniversary of the nation's first agricultural fair, which was in Pittsfield, Mass. Although fairs have added some new twists since then, they're little changed.Dancers warm up backstage while waiting to perform at the Tillamook County Fair in Tillamook, Ore.
Oregon running back Kenjon Barner finds a hole against his teammates during the team's annual spring game at Autzen Stadium in Eugene, Ore. The white team beat the green team 26-21.
Tyson Gay, left, runs to the finish line to win the men's 100 meter finals in Eugene, Ore. Gay ran in a record-setting time of 9.68 seconds but was not awarded a world record due to high wind conditions.
Tyson Gay, right, looks over at Chrisdon Hargrett at the finish line of a 100 meters qualifying heat at the U.S. Olympic trials in Eugene, Ore. Gay built a big lead and then eased up a little too much, nearly resulting in a huge blunder as he finished fourth to barely qualify to the next round.
In the quarterfinal run, Gay set an American record in the 100 with his time of 9.77 seconds.


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JNV Korea was established in the year 2006. Initially it was working in the old boys hostel of Ramanuja Hr.Sec. School,Baikunthpur,The school started functioning in the new building on 8th September 2010 at Navodaya Nagar in Kenapara of Baikunthpur situated on the bank of the River Gaze which is a life-line of Baikunthpur. The School Campus is sprawled In 15 acres of land comprising a large play ground and other sports infrastructure like 2 Basket Ball courts, Volley Ball courts .The academic block consisted of Smart Class Rooms, Computer Lab, Physics Lab, Chemistry Lab, Biology Lab, Mathematics Lab, Junior Science Lab (Integrated), Social Science Lab and Linguistics Lab, Art Room, Music Room, Indoor Games Room and well equipped Library. Internet connectivity is provided to all the departments. We are so proud to have spacious Dining Hall that can accommodate all the students at a time and well planned modern buildings that included Boys (294 Bedded) Dormitories, Girls (196 Bedded) Dormitories and 40 staff quarters.
It is our endeavor to provide quality education to our children without any much stress on curricular & co-curricular activities. All efforts are done to provide a congenial atmosphere to all. With a team of young and energetic with un limited talent & dedicated staff members JNV Korea is "A home away from Home" where students feel comfortable & do not miss their near & dear ones. J.N.V Korea is fortunate enough to have a hard working & cooperative team of staff members who perform their duties with complete dedication, commitment and leave no stone unturned to make this Vidyalaya one of the best in the State. For all around development proper stress is given on co-curricular activities where the students are provided with a platform to exhibit their talents through various competitions like debate, essay writing, drawing and painting, quiz ,elocution, Calligraphy, creative writing and music etc. are organized at regular intervals to e their creative abilities.
There is no doubt that J.N.V Korea is one of the leading institutes of the state, which is acknowledged by all in the nearby areas as a model school.


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0.46 CT. T.W. Diamond Hoop Earrings in 14K White Gold (H-I, I1)
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A beautiful pair of round diamond hoop earrings with classic styling that will endure all seasons.
A beautiful pair of round diamond hoop earrings with classic styling that will endure all seasons.
These 0.46 CT. T.W. earrings feature 14 round brilliant-cut diamonds prong-set on a mounting made of lustrous 14K white gold.
Earrings: | |
Metal: | 14K white gold |
Diamond Total Weight: | 0.46 CT. T.W. |
Diamond Cut: | Round |
Diamond Color: | H-I |
Diamond Clarity: | I1 |
Setting Type: | Prong |
Earring Dimensions: | 12.9mmL x 14.3mmW |
Back Type: | Hinged |
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These diamonds are guaranteed all natural, non-treated and non-conflict. Carat weights (CT.) and total weights (CT.T.W.) are not exact and may vary by .05 carat. Jewelry may be enlarged to show beauty of detail.
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You could even take a minute to sit down and answer these questions about yourself. Record your thoughts in a journal or create a mini album all about you. What a treasured gift to give your kids!
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If They Didn't Let It Happen On Purpose, Would We Be Here Today?
Submitted by zooamerica on Thu, 04/04/2013 - 22:33Declaration of War to Japan -
Day of Infamy speech by Franklin D. Roosevelt
December 8th 1941
"Yesterday, December 7, 1941 - a date which will live in infamy - the United States of America was suddenly and deliberately attacked by naval and air forces of the Empire of Japan."
As most people here already know by now, FDR and US intelligence knew what was coming days prior to Pearl Harbor. They knew of General Yamamoto's plans.
"...everything that the Japanese were planning to do was known to the United States..." ARMY BOARD, 1944
I think most of here would agree. They let it happen on purpose in order to justify the United States getting involved in another World War.
So my question is, would we all be here today if they didn't let Pearl Harbor happen on purpose as they did?
Would we, "all be speaking German?"
Another thing I think most of us here would agree upon is the fact that Germany more than likely would have won the war if America didn't intervene. Without the United States help, the Allies would've lost to the Axis Powers. The bankers backed both sides and could care less who won, or perhaps that isn't so?
That being said, what would the world be like today if Hitler did in fact win WW2?
Would you have ever been born? No Baby Boom in America, no you, or at least a very serious reduction in the likelihood of you ever being born. If the United States didn't help win WW2, The Baby Boomers - our parents, would have never been born.
Would your autistic child be allowed to live in the 3rd and 4th Reich? Would people of, "inferior racial hygiene," exist? Would the eugenics of Nazi Germany wipe you and your family off the map to the point of non existence?
Would you be allowed to own a gun or rifle in "America," today?
Hitler took away the guns...Stalin took away the guns.
Would we be allowed to listen to Alex Jones?
Would the United States Constitution, and our Bill of Rights even be talked about today if Hitler won WW2, or would that great, "book," be burned too?
Would France still exist? Would England still have a Queen? Would mentally handicapped people be allowed to live? Would gay people be allowed to be gay?
Would Jews exist? Would Muslims exist? Would Asians exist today if Hitler had his way and won World War 2?
Would the NFL exist? The NBA? Major League Baseball? The NHL?
McDonald's, Burger King and KFC?
Movies with black men in leading roles?
If they didn't LIHOP back in 1947...
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In 2014, we are planning to redevelop Private Healthcare UK and its sister site GoPrivate.com into a single site.
Your opinion is important to us, and so we are asking for your help to test the search we'll be using for finding a doctor, hospital, clinic or other health professional.
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Gallbladder disease is a common condition, most usually caused by gallstones. An imbalance in the constituents of bile, a fluid produced by the liver to help digest fats, results in the formation of stones made up of cholesterol, bile salts and calcium. The gallbladder, a small pear-shaped organ situated below the liver that stores bile, can become irritated and inflamed by these stones. Gallstones can also become stuck in the biliary ducts, obstructing the flow of bile from the liver.
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How Employers can Request for CRB Check in UK
CRB check in UK is required in situations where the employer's business is one of those mandated to conduct such checking on the applicant for a job. It is therefore important to note what those jobs are that require this
New online service for CRB checks
On June 17th, 2013 the Disclosure and Barring Service introduced their newest update to the program since its merger in late 2012. The new feature is an online service that will make it much easier and simpler for people to
Some important discussions on criminal record checks
Criminal record checks are one of the important processes which allow to estimate the people around us, who may have the bad intention to hurt us or the society. This record keeps data of the criminal suits filed against a
When Should I Conduct an Online CRB Check?
One often puzzling question that you might naturally have when interacting with someone new is: when should I conduct an online CRB check? A CRB check is a criminal record and background check similar to what major corporations require when
The Importance of CRB Checks in the UK
The background check that is being done by the Criminal Record Bureau of the United Kingdom holds paramount importance for a variety of reasons, as it will be discussed in the rest of this article. It is critical for employers


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Wealden MP, Charles Hendry, has announced that he will not be seeking re-election to Parliament at the next election.In a letter to the members of his Constituency Association, he has written about the privilege of being MP for Wealden, the area where he was brought up and has lived for most of his life, but he has decided that it is now the right time to move on.Mr Hendry, 53, has been MP for Wealden since 2001. It is however over twenty years since he was first elected to parliament, as MP for the High Peak in 1992, and he has contested every general election for the past thirty years.Mr Hendry held the Conservative energy portfolio for longer than anyone else, including 4 1⁄2 years in opposition and almost 2 1⁄2 years as Minister of State. He has also served as Deputy Chairman of the Conservative Party.Mr Hendry comments: "This is a decision I made some time ago. I have been incredibly privileged to represent Wealden in Parliament, which is the most wonderful constituency, both in terms of its natural beauty, but especially the kindness and warmth of its people. By the time of the next election in 2015, I will have been MP here for 14 years, and it will be 23 years since I was first elected to Parliament."Politics needs to be constantly refreshed, and I feel that having contested every election since 1983, it is now time to let someone else take on this very special role. It was a great privilege to be a Minister in Government, but the greatest honour of all was to be MP for this very special constituency, which will continue to be our home."Mr Hendry emphasised that he would continue to work for his constituents until the end of this Parliament and to support the Government's economic and welfare reforms: "My decision should not be seen either as lack of support for the Government's policies or as disappointment that I stopped being a Minister last September. I am a strong supporter of the Prime Minister and of the steps he is taking to rebuild our economy and to tackle long-standing problems, such as welfare and pension reform, which have been out off for far too long, and I will be proud to continue to stand up for the interests of my constituents, as those reforms go forward.""I am making this announcement now to give the constituency association ample time to choose a candidate who can get well-established ahead of the general election", he added.
Hendry says he will not stand in 2015 General Election
Monday, 4 March, 2013


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J.B. (play)
Written by | Archibald MacLeish |
Characters | Mr. Zuss Nickles J.B. Sarah David Jonathan Mary Ruth Rebecca First Messenger Second Messenger Girl Jolly Bildad Zophar Eliphaz Mrs. Adams Mrs. Murphy Mrs. Lesure Mrs. Botticelli A Distant Voice |
Date premiered | 11 December 1958 |
Place premiered | ANTA Playhouse New York City |
Original language | English |
Subject | a retelling of the Biblical Book of Job |
Genre | Drama |
Setting | a corner inside an enormous circus tent |
J.B. is a 1958 play written in free verse by American playwright and poet Archibald MacLeish and is a modern retelling of the story of the biblical figure Job — hence the title: J.B./Job. The play went through several incarnations before it was finally published. MacLeish began the work in 1953 as a one-act production but within three years had expanded it to a full three-act manuscript.
There are two versions of J.B. available: the original book, published by Houghton Mifflin Harcourt, and the script which MacLeish revised substantially for Broadway, published by Samuel French Inc.
Plot summary[edit]
The play opens in "a corner inside an enormous circus tent". Two vendors, Mr. Zuss (evoking the chief Greek god Zeus; zuss is also German for "sweet") and Nickles (suggesting the god of money, Mammon), begin the play-within-a-play by assuming the roles of God and Satan, respectively. They overhear J.B., a wealthy New York banker, describe his prosperity as a just reward for his faithfulness to God. Scorning him, Nickles wagers Zuss that J.B. will curse God if his life is ruined. The two then watch as J.B.'s children are killed and his property ruined and the former millionaire takes to the streets. J.B. is then visited by three Comforters (representing History, Science, and Religion) who each offer a different explanation for his plight. J.B. declines to believe any of them, instead asking God himself to explain. Instead he encounters Zuss and Nickles. Nickles urges him to commit suicide in order to spite God; Zuss offers him his old life back if he will promise to obey God. Instead, J.B. finds comfort in the person of his lone surviving family member, his wife Sarah, and they build a new life together.
Original productions[edit]
The three-act version was first performed on 11 December 1958 in New York City at the ANTA Playhouse in a production directed by Elia Kazan with a cast including Raymond Massey, Christopher Plummer, Nan Martin, Ivor Francis, Pat Hingle, Clifton James, Judith Lowry, Candy Moore, James Olson, Ford Rainey, and Andreas Voutsinas. This production won both the Pulitzer Prize for Drama[1] and the Tony Awards for Best Play and Best Direction[2] in 1959.
An off-Broadway production opened on March 17, 1962, at the Master Theatre, starring John Cazale. [3] The play was performed at the University of Nevada in Reno and Johns Hopkins University in Baltimore in 1963.
- J.B. – based on the biblical character Job; a man confronted by many tests of his faith in God.
- Sarah – J.B.'s wife; not as confident in God as J.B.
- Mr. Zuss – A balloon vendor in the circus who assumes the role of God
- Nickles – A popcorn vendor in the circus who assumes the role Satan
- The Distant Voice – An anonymous voice that prompts more action in the play, as if to make it look like God himself is watching
- the children of J.B. and Sarah: David 13; Mary, 12; Jonathan 10; Ruth 8; Rebecca, 6
- two 'buxom, middle-aged' Maids
- two Messengers: 'dressed as soldiers' in Scene Three; with 'battered felt hats...a news camera... a notebook' in Scene Four; 'wearing steel helmets and brassards' in Scene Six
- a 'stylishly dressed Girl' (Scene Four)
- in Scene Eight, et seq.: 'Four Women' (Mrs. Adams, Mrs. Botticelli, Mrs. Lesure, and Mrs. Murphy) and 'a young girl' (Jolly Adams), 'their arms filled with blankets and newspapers.'
- in Scene Nine: 'Three Comforters ... in worn-out clothing': Zophar, a fat, red-faced man wearing 'the wreck of a clerical collar'; Eliphaz, lean and dark, wearing 'an intern's jacket which once was white'; and Bildad, a squat, thick man in a ragged wind-breaker.'
External links[edit]
- J.B. at the Internet Broadway Database
- J.B. at the Internet Broadway Database
- J.B. at the Internet off-Broadway Database


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Breakup? WHAT breakup? Justin & Selena couldn't look happier to be together on their latest international trip!
Seriously, could Justin Bieber and Selena Gomez be any cuter? "Hi Japan," Selena posted July 9 on her Facebook page. "I heart you." And it looks like she also hearts boyfriend Justin, as she attached a photo of them flashing peace signs to the camera.
Justin, 18, and Selena, 19, were plagued by breakup rumors recently, but hopefully this new picture will put all the speculation to rest!
More Justin & Selena News:
- Justin Bieber's Dramatic 911 Call — His Life Was In Danger
- Justin Bieber & Selena Gomez Arrive in Japan For Romantic Trip
- Justin Bieber & Selena Gomez: 8 Reasons They MUST Stay Together
View Comment
Posted at 10:33 AM on July 18, 2012
I love Selena and Justin Bieber <3 They look so cute together <3 And I'm glad they're together <3 they fit together <3 hope not they turn up <3 to see them together is so cute, I just love it. No need to hate selena gomez just because she is with JB. There is no excuse. I do not hate selena because she is with jb, but I'm so glad they are together and hope they will be together forever.Selena is the cutest girl,she is so pretty and sweet so I certainly hope they're ok!Beliebers you who hate or do not like selena gomez, you should respect Justin for it is he really in love with selena gomez and, together with <3<3 Love you JB and Selena Gomez <3
Posted at 5:37 PM on July 15, 2012
Posted at 7:57 AM on July 14, 2012
Posted at 9:35 PM on July 11, 2012
Posted at 8:56 PM on July 11, 2012
Posted at 6:06 AM on July 11, 2012
hey.hey respect who justin likes as well as selena…being a celebrity is not easy…let them be happy…what's wrong if justin and selena are inlove..all of us needs happiness..that's our goal as human…
– haters: plss. just be happy of what is happening in the lovelife of ur idols..as a fan i think that's ur obligation…
Posted at 6:13 AM on July 12, 2012
Posted at 2:27 AM on July 11, 2012
Posted at 4:23 PM on July 10, 2012
Posted at 1:52 PM on July 10, 2012
I don't like Justin, nor do I like Selena.
Justin takes himself way too seriously, and Selena acts like a kid. Their realtionship seems so fake and disgusting.
Also, they both look – and act – like 13 year olds.
Their music suck and neither of them (epsecially Selena) can sing live. It saddens me that the music industry has come to this.
Posted at 4:27 PM on July 10, 2012
Posted at 11:59 AM on July 11, 2012
Posted at 11:35 PM on July 10, 2012
Posted at 3:59 PM on July 12, 2012
if u dont like them then thats ur problem then dont write back cuz there are lots of ppl who do like them that have good opinions of them if u dont then dont write anything and they have some pretty nice songs plus selena doesnt act like a kid and if she did how is that any of ur concern at least shes not like other ppl trying to grow up so fast at least shes enjoying her life and not being a grunch and she has a nice voice better then most ppl i bet even u so unless u have something nice to say or a good argument then keep it to urself
Posted at 1:44 PM on July 10, 2012
Posted at 1:36 PM on July 10, 2012
Justin and Selena are meant for each other. I love how justin and Selena can prove everyone wrong that they are still together and very happy with each other. I hope they never break up. They are like Romeo and Juliet. The love that they have for each other. even though they are still young. They can work on there issues. hopefully everything will fall into place without having the Stalkrazzi always following them around like puppy dogs and asking them the dumbest question. and fans getting aggressive over celebs. Fans can way overboard with celebs. I would think Celebs need there privacy and not having annoying fans following them around like they are somewhat of a trophy. Which clearly there not.
Posted at 1:31 PM on July 10, 2012
Posted at 11:11 AM on July 10, 2012
Posted at 11:34 AM on July 10, 2012
Posted at 11:42 AM on July 10, 2012
Posted at 12:21 PM on July 10, 2012
Posted at 2:56 PM on July 10, 2012
Posted at 1:29 PM on July 10, 2012
Posted at 11:40 AM on July 12, 2012


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Cemetery in Conecuh County, Alabama, USA.
Latitude: : Longitude:
Blogs and Websites Near Straughn Cemetery, Alabama - GeoURL
Straughn Cemetery Map - Multimap
Straughn Cemetery Street Map and Satellite Photo - Google Maps
Straughn Cemetery Aerial Photo and Topo Map - Terraserver
Straughn Cemetery Map - MSN
Environmental Hazards, Flood Area Maps, Boundaries - EPA
Straughn Cemetery Area Map - MapQuest
Weather Forecast near Straughn Cemetery - Multimap
The weather forecast links don't work for all places yet.
Some random places: Vsetin Morgnec MSPCA Hospital Fombell Tsay O Ah Butte


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Fish Tacos
8-12 filets of Tilapia (frozen or fresh)
12-20 small flour tortillas
1 cup of finely chopped cilantro
4 limes wedged
1/2 head of iceberg lettuce, chopped fine
4 tomatoes diced
1 medium-large onion diced
2 cups of italian bread crumbs
seasoning salt or creole seasoning
2 cups of vegetable oil, olive oil, or lard (use to pan fry fish)
guacamole, salsa, and your queso
In pie pan/deep dish add your italian bread crumbs.
in large enough pan to fit at least two filets at a time, add about 1 cup of oil and bring up to a sizzling temp. (after frying about half the fish, you may need to add more oil to the pan)
if frozen thaw your tilapia in lukewarm water, drain well.
Once oil is ready, take one of the filets, thoroughly coat both sides with the bread crumbs. Place in the oil and cook til each side is brown (~2-3 minutes/side). Place on sheets of paper towl to drain away more of the oil.
Lightly season the top side of fish with you salt or creole seasoning.
While frying up the rest of your filets, chop up all of your accouterments.
When everything is ready, microwave your tortillas for about 30 seconds on high, completely covered in papertowel or a clean dishtowel.
make a taco building buffet: add your fish, a little queso, your veggies, a pinch of cilantro, and then salsa and/or guac. Use the lime wedges to give your taco a little extra kick of citrus!


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Biographical and Playing Info
Given Name: Philip Anthony Mankowski
Born: Buffalo, NY, USA, in 1953
School: Did not attend college.
Primary Position: Third Base
Batted: Left Threw: Right
Major League Games: 269
Primary Team: Detroit Tigers
Played For
Detroit Tigers (1976-1979)
New York Mets (1980-1982)
First major league game: 8/30/1976
Final major league game: 7/21/1982
Hall of Fame Voting
No Hall of Fame elections.
See his complete statistical record at baseball-reference.com


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169 posts found | |
On a more serious note there are many draws to EVE online for anyone who isn't afraid to lose something. In EVE there are consequences to your actions. something most games lack nowadays. Clever play is rewarded, foolishness is punished. You can play any role you could want in a space sim, Trader, merchant, pirate, bounty hunter(soon?) logistics manager, Fleet commander, spy, recon, scout, tackler etc etc. Ht eonly limitation is your skills and knowledge. Even when your not logged in your still progressing through skill training so you dont feel that compulsion to log in daily like most MMO's do. THe ability to effect the gameplay of others ona massive scale through smaller actions etc etc there is so much to EVE beyond the whole "spreadsheets in space" moniker. The catch is you must be willing to throw most of your MMO preconceptions out the window in order to get the most satisfaction out of it. A newbie frigate can be just as valuable as a capital ship in the right situation. a tech 1 battleship can be just as beneficial as a Tech 3 cruise. It's all about tactial knowledge and knowing when to fight and when to run. the market cane be a game unto itself with station trading (theres a reason they employed a Dow jones market analyst for so long) When in doubt, get more explosives. |
i play eve because it is a player driven mmo. love the concept of no rules to follow either. well there are some rules. but i'm referring to the freedom you get compared to any other mmo. if you wanted to scam you don't get banned. if you want to grief you can. i use to play gw2 and i actually got rid of my account and just decided to stick with eve since no other mmo can offer the freedom i get in eve. i mean i think it is also how you can make a players life in the game a really painful experience. he might even quit because he cant handle the torture. no im not a masochist lol. but i believe any eve player will tell you the same response i just said. i mean i just lost a 2.7 bill 100mn legion yesterday in -a- trip a wanted my fleet so dead that they hot dropped a 20 man fleet on a 6 man fleet. tengu fleet with logis in system + ecm lol so ya they wanted my fleet bad lol. it's k we killed em alot and is winning the war. guess that is the reason why they are mad since they are about to loose their space.
Bitter Vet™
Joined: 9/13/06 Fools find no pleasure in understanding, but delight in airing their own opinions. Pvbs 18:2, NIV |
Originally posted by Quirhid Ohh.....I can't resist..... Just because you don't like a game doesn't mean it isn't a good one. Arrogant, Condescending, Dismissive, Elitist, "Meany", you speak as if these are bad things? |
Originally posted by Kyleran I would imagine he means "better" in his opinion. Although considering the poster, maybe not. (I joke ofc). |
Bitter Vet™
Joined: 9/13/06 Fools find no pleasure in understanding, but delight in airing their own opinions. Pvbs 18:2, NIV |
Originally posted by bunnyhopper Yeah, I was just messing with him since he's said the same to me when I've slammed another game. Arrogant, Condescending, Dismissive, Elitist, "Meany", you speak as if these are bad things? |
Eve-online was a once in a life time, right place right time, do it right the first time, niche MMO that will likely never happen again. It's as big of a freak accident as WoW. Granted my comment doesn't intend to slight the developers, but in all honesty they just came out at the perfect time and did something right that kept players hooked. Eve is about the only true sandbox we have...There are plenty of other games that come close but Eve about hits the nail on the head. I know, I personally still have my battleship sitting in [forget the name of the system and station] that I haven't touched in a long time. Mostly because other games have me occupied *coug* GW2. I'm sure I will eventually go back to Eve...when they give me the damn walking in stations!!! >:O Note: I think most people who play Eve play it off and on. Unless they are just super religious Eve players. |
i think i played so much theme park mmos that i got tired of it. the purpose in the end is to get geared or pvp. least in eve you don't have an endgame. oh and i think star citizen will be an epic game if robert does ever deliver
Originally posted by Gdemami You do understand that 80% of the EVE population is playing in the part of the universe that would be considered the PvE part of EVE. And that is according to CCP. Emergent gameplay is what makes EVE great. |
No predefined endgame.
Let's build the ultimate MMO 1 feature at a time "blocked nariusseldon since forever" |
Originally posted by Uhwop agree with this post. like incursions mining/manufacturing. missioning/ratting wh is combination |
Not sure if you made a typo or what your point actually is...it does not relate to my point in any way shape or form. |
Originally posted by Gdemami big sov owners like test -a- goons . test has like 9700+ members atm and goons has like 8000 something a has like 3000 something. and i forgot the other sov owner that owns drone space. but they are a huge alliane as well. and if you're not a sov owner you're low sec occuppier. like e- uni who lives in maseera is a pretty big alliance. so the 20% ya thats the source. look at the total number that gets on from peaktime to downtime. you can easily figure it out bro |
Yeah, only a minority of players are involved in 0.0 warfare...still does not relate to what I have said. Bigger = better in EVE PVE fully applies. |
Originally posted by Kyleran GW2 perchance? This doom and gloom thread was brought to you by Chin Up™ the new ultra high caffeine soft drink for gamers who just need that boost of happiness after a long forum session. |
Originally posted by aligada87 Many of those players you list rarely go to null-sec and most spend the majority of their time in 0.2 or higher. Null sec is far safer then 0.2-0.5, where all the gate campers and 1337 kiddies live. A large proportion of pvpers do not reside in null sec, never have, never will. This is why the 80% is probably a low estimation, most pvpers reside in the so-called "pve" areas, this is the thing about EvE, nowhere is truly safe. Expresso gave me a Hearthstone beta key.....I'm so happy :) |
Making assumptions without prior experience is rarely any good. Sorry but that is not how the game is. Low sec is the least populated area in EVE and 0.0 gate camps are way deadlier. |
Originally posted by Gdemami could you define your bigger=better in eve pve fully applies theory? i'm not trying to be rude. just don't get what you mean. are you saying pve is the majority that what makes eve system? cause if so i can disagree. all pve concept involved pvp. whether you get ganked or not. you may not participate in it. but overall you will be still be attacked by pvpers which once a pvper attacks u. you are participating in pvp system of eve. and if you want to even get into more mental pvp lol. you can think of scamming people as a mind pvp lol. like setting up those epic scamms people have to get as much isk out of u. for example, solar blink. this can be considerd as pvp with the mind lol |
Bigger as ship size. PVE in EVE scales with ship size and creates an "end game" for largest ships. There is no point specializing in frigates if you want to PVE. |
Originally posted by Zinzan lol try telling that to test or goons or the other big alliance i listed. i live in null and have for over 2 yrs lol. compared to low sec null is most populated but there are more low sec pvpers. low sec pvpers doesnt really mean that makes up their population. cause in the end most of them will go back to high sec and just live there. compared to null that is basically your home. i know i rarely go back to high sec since i live in k-6 and many in my corp does same. and if we do need something that we can't get in null we just send a hauler out in jita then bam . but this happens probably 2-3x a month. |
Originally posted by Gdemami well that is true. but i can easily rat or do plex run in a t3 and make good money without having to worry bout me being in a carrier who will be a large target who cant escape lol. i think cruiser ship is smallest ship u can do pve stuff though. anything smaller dont think it's possible |


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12 Days of Holiday Gifts: Infused Vodka
by Dana Angelo White in 12 Days of Holiday Gifts, Healthy Holidays, December 5, 2011
Trying to keep alcohol consumption modest this holiday season? Make the most of your celebratory sips with these sweet, tangy, spicy and even herbaceous homemade vodka infusions.
Smart Sipping
Spiking vodka with seasonal flavors makes a festive and creative gift. A 1.5 fluid ounce "shot" of vodka contains about 100 calories and most infusions add no additional calories. Those made with sugar will add 15 calories per teaspoon.
To infuse, combine vodka and desired flavorings in a sealed container and allow to steep in a cool, dry place for at least 1 week. The longer it sits, the more flavorful it will be. When mixture reaches desired potency, strain and it's ready to serve.
Turn up the volume with these flavor-bursting combinations. Each of the measurements below is enough to infuse a 750-milliliter bottle of vodka (that's just over 3 cups).
• Add the zest of 2 tangerines and 1 lime
• Serve on the rocks or mixed with tonic or club soda
Chili Pepper
• Add 3 to 4 hot chilies (or more to taste), using a sharp knife make a slit down the middle of each pepper
• Perfect for a spicy Blood Mary at a post-holiday brunch
• Check out Michael Chiarello's recipe
• Add a splash of cranberry juice and orange liqueur for a batch of festive cosmos
Lavender -Vanilla
• Add 2 sprigs of fresh lavender and 1 large vanilla bean, split
• Shake with ice, lemonade and splash of lemon-lime soda for a taste of summer
Red & Green
• Take this Food Network Kitchen's recipe for Orange Vodka and swap in red or green candies
• Serve on the rocks or in a martini
To package flavored vodka as a gift, re-purpose a wine bottle. Wash an empty bottle well to remove labels. Top with a cork or wine stopper. For an extra special twist, paint the front of the bottle with chalkboard paint and write a message.
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The Game Lab at the Hunt Library now open during regular library hours
And now it is open for drop-in play during all regular library hours (except when reserved by graduate students or faculty). During open hours, the 21.3 foot wide X 5 foot tall display wall offers xBox, PS3, and Wii for free play. Faculty and graduate students can reserve the lab for research or curricular activities for up to 4 hours; see http://www.lib.ncsu.edu/spaces/game-lab.


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Developmental variations in sesquiterpenoid biosynthesis in East Indian sandalwood tree (Santalum album L.)
- Biswapriya B. Misra,
- Satyahari Dey
- … show all 2 hide
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The East Indian sandalwood tree, Santalum album L. is known for its fragrant heartwood and essential oil. The major bioactive principles of sandalwood oil, i.e., sesquiterpenoids (C15 isoprenoids), are known as 'santalols' and are globally used in medicinal, cosmetic, dietary, and aromatherapeutic applications. However, there are no available reports on the biosynthesis and metabolism of isoprenoids in this forest tree. Hence, we provide detailed insights into sesquiterpenoid metabolism across several in vitro and in vivo developmental stages. Since no molecular information was available, several genes encoding enzymes participating in early and critical steps of isoprenoid biosynthetic pathways were isolated using degenerate primers, and their expression patterns across the developmental stages were studied by semi-quantitative reverse transcription PCR. Results indicate that the isoprenoid biosynthetic pathway is differentially regulated with development and in tissue-specific manner. Accumulation of plastidial isoprenoid pigments increased with development, while the amounts of farnesylated intermediates decreased with maturation, thereby possibly indicating conversion into sesquiterpenoids. A differential expression pattern was observed for hydroxy-3-methylglutaryl coenzyme A reductase and 1-deoxyxyulose-5-phosphate synthase at the levels of transcripts and proteins, indicating post-transcriptional regulation. Transcript levels of farnesyl pyrophsophate, sesquiterpene and monoterpene synthases were quantitatively higher in callus, and lower in matured tree leaves. Sesquiterpene synthase activity across different developmental stages indicated a tissue-specific conversion and accumulation. Henceforth, the results would facilitate characterization of routes of sandalwood oil biosynthesis and for future improvement of sesquiterpenoid content in this tree.
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- Title
- Developmental variations in sesquiterpenoid biosynthesis in East Indian sandalwood tree (Santalum album L.)
- Journal
Volume 27, Issue 4 , pp 1071-1086
- Cover Date
- 2013-08-01
- 10.1007/s00468-013-0858-0
- Print ISSN
- 0931-1890
- Online ISSN
- 1432-2285
- Publisher
- Springer Berlin Heidelberg
- Additional Links
- Topics
- Keywords
- Development
- Farnesyl pyrophosphate
- In vitro
- Sandalwood
- Santalene
- Santalum album L.
- Sesquiterpenoid
- Somatic embryo
- Authors
- Biswapriya B. Misra (1) (2)
- Satyahari Dey (1)
- Author Affiliations
- 1. Plant Biotechnology Laboratory, Department of Biotechnology, Indian Institute of Technology Kharagpur, Midnapore (West), Kharagpur, 721302, West Bengal, India
- 2. Center for Chemical Biology, Universiti Sains Malaysia (CCB@USM), 1st Floor Block B, No 10, Persiaran Bukit Jambul, 11900, Bayan Lepas, Pulau Pinang, Malaysia


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Zayn and Perrie are definitely one of Hollywood's most beloved couples and maybe even the cutest too. Adorable selfies of the couple recently made their way onto Instagram showing the stars making super funny faces together. Who wouldn't want a love like Zayn & Perrie's!
Like two peas in a pod! Zayn Malik and Perrie Edwards have one of the most beautiful relationships in Hollywood. The couple's love is undeniable especially with the release of these extremely adorable photos that surfaced on Instagram.
Perrie Gets Past Zayn's Cheating Scandal
Perrie posted a couple of these silly selfies to her Instagram account that show her and her gorgeous boyfriend making duck faces, blowing kisses, and sticking out their tongues. They're so in love!
It's great that the two have such a strong relationship because if they didn't Zayn's cheating scandal could have taken a devastating toll on them. Zayn was accused of cheating on his singing girlfriend in January 2013 with an Australian waitress named Courtney Webb. The waitress made many claims that she slept with the rising star but Zayn totally denied the allegations. Since the scandal, Perrie and Zayn have been totally inseparable and completely obsessed over one another.
The Bond Of Friendship Overrules All
Perrie laughed at the allegations of her One Direction boyfriend stepping out on her. In March 2013, the signer told The Mirror that she doesn't let the gossip she reads in the tabloids get to her. Perrie also reveled to the site that not only is Zayn her boyfriend but he's her best friend too.
Hollywoodlifers, how cute are Zayn and Perrie silly selfies?
– Brittany Chanel Jackson
More Perrie Edwards and Zayn Malik News:
- Perrie Edwards Out With Mystery Man — Trouble With Zayn Malik?
- Zayn Malik & Perrie Edwards Stronger Than Ever After Cheating Scandal
- Zayn Malik Back With Girlfriend Perrie Edwards After Cheating Claim
View Comment
Perrie Edwards
Posted at 10:53 AM on February 11, 2014
Posted at 5:18 PM on January 20, 2014
Miss Routh
Posted at 6:07 AM on September 9, 2013
Posted at 11:46 AM on August 27, 2013
Zayn and Perrie are the cutest couple in the world and I can see the love in his eyes when he looks at her. i can only imagine how it must feel for her to have a guy love her so much and to have a propose on a romantic weekend together I hope someday I have a love like this and congrats Zerrie shipper forever
Posted at 3:03 PM on October 13, 2013
Posted at 1:02 PM on May 29, 2013
"ang pogi nman ng "mapapangasawa ko(future husband)" waahhhah addict lang e!! :D ya know Zain…sometimes i get jealous with that girl who caught your eye …but of course for now all i ihave to do is just wait here in the wings till the moment comes that our God will mate us as u know what we call Destiny though we hve different religion :) !!
wow saaabeeh??!!
p.s: i dont hate Perrie, because she's nice and makes you happy Zain baby :)
Posted at 4:43 PM on May 4, 2013
"Zayn and Perrie are definitely one of Hollywood's most beloved couples and maybe even the cutest too." I Don't think they are 'definitely one of Hollywood's most beloved couples' becouse nobody knows Perrie… And i don't really like her.. I can't hate her couse i don't know her personality.. But i don't like this Couple, but i'm not jealous or hate them.
Posted at 8:05 PM on April 24, 2013
harrys wifee
Posted at 9:24 PM on April 23, 2013
They are an ok couple. Definitly not the cutest. I could see zayn dating selena gomez that would be an adorable couple. Perries to girly and truthfully not all that pretty. I dont see zayn liking a girl like her. And zayns duck face is waay better than perries. She looks like shes constipated. LUV U ZAYN:)
Posted at 3:10 PM on October 13, 2013
Posted at 5:28 PM on April 21, 2013
Posted at 4:24 PM on April 21, 2013
Posted at 8:50 AM on April 21, 2013
Posted at 6:40 PM on April 20, 2013


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Take your alarm on the go with Free Alarm Clock Portable
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An online Help file provides basic instructions, but most users won't need it; it's quite easy to figure out. Overall, Free Alarm Clock Portable wasn't anything we hadn't seen before, but we think it's a great choice for a simple, functional alarm clock, and we recommend it.
Free Alarm Clock Portable comes as a ZIP file and is accessible after extraction with no need for installation.