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The devil is in the details. And the producer of ESAT, Abebe Gellaw, is that devil. Abebe says he got his information about Prime Minister Meles Zenawi's death NOT from International Crisis Group [ICG] per se but from an anonymous source within ICG – thus rendering ICG's twit a day or so ago and the jeering pro-ruling minority chatter irrelevant. ICG's position is understandable. It is not going to make a public announcement of a sensitive security issue of this nature without also negating its own commitment to "preventing and resolving deadly conflicts."
We are saddened by the way the Prime Minister's end came. His entrance into the national scene was sponsored by a foreign country; secrecy, lies, and violence attended his every step, up until he exited. His condition and whereabouts turned out to be an embarrassment and a subject of malice and confusion. His mentor, Sebhat Nega, publicly disowned him, so to speak, when he said the ruling minority could function without Meles. He lived and died disrespecting the Ethiopian people and never gaining their trust or respect [all this is documented]. Let us not forget that his medical expenses are covered by Ethiopian taxpayer and, hence, an official report on his health and whereabouts would have only been appropriate. [Contrast this with ex-President Negasso recently turning to Ethiopians to raise funds to cover his medical expenses in Germany.] Finally, how outlandish would it be to assume that Meles Zenawi's body could have already been buried or cremated?
To be fair, a Waltenegus Dargie [20 July, 2012; Ethiomedia] did make an educated and a bold guess that the Prime Minister has expired. Ethiomedia [21 July, 2012] also came out with the news that the Prime Minister is "clinically dead." The private Weekly Feteh was on course when it was summarily shut down. What makes ESAT reporting different is the credibility it attached to its source and the failure of Ethiopian leaders to come up with evidence to the contrary. Time will reveal the rest of the story. Abebe Gellaw's counter report also made us curious as to how the less than a month-old Ethiopian National Transitional Council [ENTC] could so soon request recognition from the US State Department and the Australian Government and have access to such a privileged information so early [15 July 2012] to issue a press release.
Interestingly, DailyEthiopia [Addis Ababa, 30 July 2012] listed, in what appeared to be a eulogy of sorts, the stakes to local and regional politics without Meles and yet not admitting Meles has died. As the quote below would show the attempt at cover-up was not quite successful. Moreover, the write-up seeks to paint a grim post-Meles picture for the consumption of US policy-makers in the hope of extending the tenure of TPLF. The fact is that anarchy was predicted after the fall of governments of Emperor Haileselassie, Colonel Mengistu and now Meles. What the predictions failed to comprehend is, however, the decency and faith of Ethiopian people. Let not TPLF remnants or foreign groups [ICG and others] sell us any such spurious tales. All they want is to deceptively explain away their intense desire to shape matters to favor their interests. Here is the quote from DailyEthiopia:
If Zenawi goes, the cohesion of this security and political structure will be at serious risk. What complicates matters is that the threat is not only from within. Eritrea will be keenly watching the fate of its enemy. Somali, Oromo and other rebel groups are currently based in its capital. Asmara may also wage full-scale war if the TPLF leadership ends up in disarray. Last week, exiled Oromo rebel factions met in Norway, Oslo to discuss the future role of their struggle. They agreed to unify their fight against the current Ethiopian regime. The deteriorating health of Zenawi, 57, can only embolden these opposition groups, though the home-based opposition are weak and fragmented.
In the meantime, few things should worry us all. Would the chaotic situation give US "experts" yet another chance to define the direction of the country, including appointing a leader? Would the US initiate an arrangement between Ethiopia and Eritrea on the pretext of the unresolved border issue and Assab port? Every one of the above items is not in the long term interest of Ethiopia. What can the opposition do to avert another destructive regime from taking power?
The Saudi Al Amoudi is another major player in local politics and economy. He has had an unusually unfair advantage in his shady business dealings [70% share in the gold mining sector, etc – in effect reaping disproportionately the wealth due poor Ethiopian women and children]. As reported by The Reporter last month, the Saudi could actually renege on agreements to build roads and get away with it because he is friends with the Prime Minister and Information Minister and so on. Let us remember Al Amoudi played a role in ex-Prime Minister Tamrat Layne's downfall. Speeches both he and Information Minister Bereket made at a book signing ceremony revealed recently that he had given generous financial gifts to the minister's pet projects, including paying for publishing the latter's and his in-law's books. On July 20, 2012, Venturses.com had an article on Al Amoudi. The gist of the article was to tell the world that Al Amoudi made his fortune elsewhere [Saudi and Sweden in particular] and that his business in Ethiopia has been simply a labor of love! Now that is one rotten lie, is it not? The one problem facing any who want to verify such statements is that his business dealings in Ethiopia are intertwined with the life of the secretive ruling minority [who more than likely are receiving a cut and an account in Western or Arab banks].
In mid-July, Al Amoudi's company [MIDROC] was granted a loan of about USD 53 million by the Commercial Bank of Ethiopia. Weird, is it not? And the Board Chair to clear such a grant is none other than Information Minister Bereket! It is now rumored that large sums of money is being flown out of the country. Will Bereket now suddenly flee the country? With co-conspirators Meles and Bereket out of the way will the Saudi Al Amoudi move away and leave us holding the bag? Will we have a task force to hunt down such individuals and reclaim stolen funds from state treasury? What mechanisms exist to control or report such activities when the Security Chief, CEO of the national carrier, Airport security, national bank board chair, foreign ministry head, etc are all members of the secretive ruling junta? Of course there is no way to stop it or even figure out who is doing what. We are sure the US and Britain know what is going on but would certainly prefer to not interfere and jeopardize a far larger agenda they have mapped out for the country and region.
Once again we are witnessing a group of leaders that are a danger to the very existence of our nation. We need no further reason than this to come together and challenge such leaders and the system they erected. Another issue is this: Now that Meles is out of the way, will leaders Ethiomedia identified as Eritreans be removed from power? If indeed Tewodros Adhanom, General Samora, Berhane, Bereket, etc., are Eritreans and sympathizers of Eritrean causes they need to be dumped now than later; the nation should not get embroiled in Eritrea by foolishly compromising its national security.
We pray the Lord grant Prime Minister Meles Zenawi's family comfort. Abebe's analysis was commendable. It is unfortunate that many of us appear to be taking pleasure from death of the Prime Minister. After all, Meles Zenawi is or was the leader of the country no matter how bad he governed. What's more, we need to be sensitive to the feelings of the family at the moment going through a traumatic event. In other words, it is one thing to confront those ruling over us, to poke fun at them and to remind them they are mere mortals and altogether another matter to not respect their office and/or violate their humanity.


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DEXTER LAKE, Ore. — The weekend is revving up at Dexter Lake, as boaters arrive in town for the Columbia Drag Boat Association Northwest Nationals.
Organizers say the event features some of the hottest action in the country. You'll see drag boats that reach speeds up to 230 mph.
Travel Lane County says three drag boat events are held on Dexter Lake each year bringing in nearly a million dollars.
"It's a very significant group that really does draw a lot of publicity to the area and a lot of economic impacts," said Lisa Lawton, Travel Lane County Director of Community Relations.
Lisa Lawton says Dexter Lake is the place to be. There are a number of annual recreational events at the lake.

subset: commoncrawl


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NBA lockout has been in the works since at least 2005 -- and won't be over soon
These Denver blog posts are built to last.
Denver Stiffs' Jeffrey Morton traces the NBA lockout's roots to the last decade's NHL work stoppage
Denver Infill offers an update on the modernization of the Cesar Chavez federal building.
Things to Do in Denver When You're Broke: Working too hard is a common death-bed regret. So take the weekend off.
Sponsor Content


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"We knew this one black market, for computers and electronics, but we were surprised at how quickly all these other sellers came together," he says.
Jose and Juan decided to organize the email lists by products. One list was for computers, another for cars. But there was just too much. The lists, Jose decided, had become a revolico — a big mess.
So in December 2007, the two friends — both done with college and working as programmers — built a website for all the ads. Jose modeled it on Craigslist, a site he'd studied at the university.
The project was a colossal risk. Jose and Juan were putting a black market on the web and offering Cubans an open forum on the internet. The site is registered through DomainsByProxy.com, a company based in Scottsdale, Arizona.
Jose says the state didn't approve the site, and he hosted it on servers outside Cuba to minimize the risk of authorities' linking him to the site. If he censored political posts, he believed, they might not shut it down.
He clearly never intended the site as an act of defiance. He says he simply wanted to make things a little better in Havana. "Everyone in Cuba uses the black market because you have to. We wanted to make it a little easier," he explains. "At least for those who have internet."
Young Cubans
Sasha Rodriguez squirmed in the thick, wet air of the Havana summer of 1999, her tanned face ghostly in the blue-and-white light glowing from an ancient monitor. "Isn't it time yet?" she whispered to a friend. Four others who had crammed into the stifling, cluttered room nodded and grumbled.
"No," her friend whispered back. "We have to wait till midnight or it won't work."
A flash of excitement shot up Sasha's spine. The teenagers were breaking not only their parents' rules but also Cuban law. They'd used even older computers at school to type essays about the revolution, but Sasha's friend, Enrique, a daring boy who was good with computers, had promised something special tonight.
Just past midnight, Enrique double-clicked an icon and held his hand over the modem to muffle the sound. The teenagers held their breath as the dial-up tone beeped, clicked, and hissed. But Enrique's parents, snoring in the next room, didn't stir.
"Here we go," he breathed, as the screen slowly loaded a teen chatroom.
Sasha held her breath as her friend typed a message on the screen: ¡Hola! ¿Quién está en Miami?
A boy their age named Mike chatted back. He lived in Miami, he said. ¿Como está la Habana?
The friends gasped and laughed. They spent hours in that room, waiting as their tenuous dial-up died and reconnected. They asked their new friend about life in South Florida. "For me, it was like, 'Oh my God. Miami actually exists outside of my imagination. There are kids like me living there,' " Sasha says. "It was life-changing."
The chat nearly a decade ago now seems a lifetime away to the erudite 22-year-old Michigan State law student, who left Cuba for South Florida in 2005. (She asked that her first name be changed because she frequently returns to the island to see family.) But it's exactly the kind of experience that has shaped a generation of young Cubans who are connected to the world outside their totalitarian island. It's something their parents and older siblings never knew.
Only about 200,000 Cubans have regular access to the internet, according to a 2007 study — the most recent available — by the International Telecommunications Union. That amounts to just 2 percent of the population — by far the lowest percentage in Latin America.
Most people log on at schools or businesses, where the web is tightly restricted by censors. But, as Sasha discovered, many young, savvy Cubans have found illegal hookups. Some hack into phone lines or buy legit internet time from journalists or lawyers who receive state web access and earn a few bucks by selling off the bandwidth.
That's only the latest development in the black market. Sasha's father worked at a state-controlled bakery, and at home her mother made and sold illegal pastelitos, pan, and empanadas to neighbors.
These days, Sasha says, her friends and relatives living on the island have turned to the web for some of the transactions that used to happen on street corners and in living rooms. "My friends are all on Facebook, they're emailing, and they're talking online," she says. "Cuba used to be a place where you connected to your neighbors, your classmates, but that was it. You were walled off. Not anymore."
Of course, there's a dark side to that growing access. Just ask Giselle Recarey Delgado. She grew up in one of the most dangerous places in Havana — a house with two dissident parents. Her father, Hector Palacio, spoke out frequently about Fidel Castro's human rights abuses. Secret police raided Giselle's home more than five times and dragged her dad to jail. Once he stayed there for four years. Her mother, Gisela Delgado, still runs Cuba's Independent Library Project, a group that hosts reading sessions of banned books at its members' homes.


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Puzuzu brings you a beginners guide on how to get started in Spells and Magic and use this site to help you.
What is Thou looking for? If you can't find it, then search the web for right here...
Click on the link in each paragraph to learn the subject at hand.
First let me tell you that if you are not interested in making Magic and the Occult a way of life, then you should not "Dabble" or mess with any of this information.
One must Master several things before ever attempting to do Spells! One should learn how the Universe works and know thyself physically and spiritually. One should study any and all "Occult books" you can get your hands on and study all aspects of the Occult. This means that you should also study different Paths and keep and open mind. For truly all religions are tied together. Do not worry over who is right and who is wrong. The real truth is you should stay away from any religion, so that you are not locked into a belief system. The more knowledge you take in, the smarter and more powerful you will become, for the brain will grow new cells as we become more intelligent. Remember this... never stop learning, no matter how much you know.
So here we go...
suggest that you study and Master my "Dream Recall". It is quite
easy to learn and you will be amazed at the results. This is a must and will
teach you much about yourself. It will also lead into "Astral Projection",
later down the line. This should be practiced for several months, keeping
a diary.
Do your stretching and so forth, then lay down, close your eyes and picture a big trash dumpster on your mental screen. Now take all you worries, one by one such as your bills, your girlfriend/boyfriend, your enemies, your friends, your car, and everything that you think about or worry about and put them in the dumpster one by one. When you are done, close the lid and lock it! then push it off your mental screen so that you do not see it any more.
At this time I should warn you of one thing. Do not be a "Dabbler". What is a Dabbler? You will find many of then out there and it is easy for you to fall into this trap. A Dabbler is a person who reads maybe one book on Magic and does a spell then goes around professing to be Practitioner of the Occult Arts. I have seen so many out there on the Web. Yes you little Assholes who make a Web site and claim to be a Witch or Sorcerer and post Spells that you have stolen from other sites. you do this all for attention, so that people will think you are important!
Magic is a way of life, not a game. Those of you whom Dabble will only get hurt. You will attract things around you that you cannot control. Therefore, a Dabbler is someone who does not study and does spells every once and a while, with no knowledge of how spells really work. This is why one must study, study, study before doing spells.
Now remember this, Astral Projection or OBE's
(out of body experience) can take anywhere from weeks to years to master and
you must take your time and do not give up. My method for doing this is one
on many, many out there and you will find that what works for one person does
not work for you. So find other books on the subject and try different methods
until you find what works for you.
7. Once you have mastered most of this information, then it will be time to try your first "Spell". I suggest that you start with something very simple, such as a "Money spell" or a "Good Luck spell" or perhaps a "Protection spell" .
*Stay away from the Black Magic until you have a couple years of practice and knowledge. You will only hurt yourself if it backfires on you!*
There are many "Spells" to choose from on my site. Some of them are really good and some that are not so good. So you will have to try them out out see what works best for you. Remember that just because a spell does not work, does mean that it is not good. One must have practice and built up their magical power along with learning, as I mention earlier about "why, how come, and when" spells work.
However, many of the spells contain parts
where "Candles" are needed and
one must learn how to use "Candles" and dress them
properly along with knowing which colors to use. This is a must in all magical
From here out you can venture into the more intense parts of the Occult on my site. This page was to simple get you started in the right direction. Remember to do good unto others!
Good Luck and many Blessings upon you! "Puzuzu"
What are you looking for? If you can't find it, then search the web for right here...


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Thunderbird Batch Print to PDF
Have you ever required or wanted to copy or Print EML files and EML attachments that you received in your Thunderbird email box ? Get Thunderbird Emails Batch Print to Adobe PDF utility for quick Thunderbird emails to PDF conversion, this service also enables you to print email files in PDF suavely.
If you are comfortable with its features and working process, here is a speedy technique to achieve Thunderbird to PDF conversion. The EML to PDF Converter tool offers this really suave application for Thunderbird Batch Print to PDF. This utility has it all in itself to efficiently see to the conversion of Batches of EML files into Adobe Acrobat PDF file format.
Software Demo edition helps you to Transfer 10 EML messages into Adobe file format.
If you want to stop wasting your time on the complications that batch EML to PDF conversion has, then there are few simple steps to do Thunderbird Batch Print to Adobe PDF conversion in quickest and simplest way.
Easy Guide for Thunderbird Batch Print to Adobe PDF -
Simply download the software
Install EML to PDF Converter software and Run.
Select Add EML file (S) button to convert single Thunderbird EML file to PDF or select Add Folder having EML file (S) button to Transfer Thunderbird Batch Print to PDF.
Select File naming options to choose your converted file format.
Then select save attachments option, you can select save attachments together with EML files folder button or select save attachments in separate sub-folder button.
After all these steps you have to click on Convert Messages to PDF switch to start the Thunderbird Batch EML to PDF Conversion process, after conversion process it will ask you location to save Transferred PDF Files.
Thunderbird Batch Print to Adobe PDF tool is the apt solution that allows you to convert or move big batches of email from Thunderbird email environment to Adobe PDF format all along with total email components - eml header, attached files, embedded images and other, so we suggest you to try the evaluation edition of EML to PDF Converter tool now, that gives you the chance to judge the software product.


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Yellow and Black is probably the most powerful color combination on Earth…
These two hues command our attention like no other color duo can. In nature, yellow and black insects warn us of their danger or perhaps attract us to their beauty.
On the road, the same colors catch the eye of drivers and communicate the need for extreme caution.
So how does this translate into interiors? Spaces that combine the cheerfulness and radiance of yellow with the sophistication and elegance of black provide a very dramatic setting that is both lighthearted and refined — as shown by the following two spaces designed by Tracy Murdock.
By adding white or gray, the strength of yellow and black is lessened; therefore creating a space that is not so startling but still lively.
{printed canvas available at The Contemporary Home UK}
{Viceroy Santa Monica Hotel – design by Kelly Wearstler}
A yellow and black space is bold but it need not be too brash. Avoid equal amounts of each hue by using one as the dominant color and the other as an accent. Also remember to use splashes of white, gray or any pastel to soften the color scheme. Follow these guidelines and you too can create an attention-getting space that will also put a smile on your face.


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I can't remember a time when I did not love Tony Curtis. I remember watching his movies with my mother when I was little and her swooning over him, even as a cartoon, on The Flintstones. When my father was young he looked just like Mr. Curtis. Maybe that's why I always thought... read on
Bethenny Frankel's Dog Cookie is Now Following Me on Twitter
September 30, 2010 | 3:50 pm
I loved Bethenny Frankel on The Real Housewives of New York City. I thought she was relatable, funny as hell, and very entertaining. When she got her own show however, I felt she changed... read on


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Wylie Chen
Vice President - Programs & Grants
Wylie Chen joined the Foundation in July 2010 and assumed the role of Vice President - Programs & Grants in February 2015 after working at the Children's Defense Fund (CDF) in Washington D.C. He most recently served as the Senior Manager for the CDF Freedom Schools program, a national summer and after school literacy program serving over 9,000 low income children nationwide. At CDF, he also served as the Government Relations Strategist and as National Coordinator for Youth Outreach, working to address child poverty through policy and advocacy. Wylie previously worked at the Advocacy Institute in Washington D.C. as the Angie Martin Public Interest Fellow, directed an English program at Da Hua High School in Taiwan, and worked for U.S. Senator Ron Wyden of Oregon. He currently serves as a Commissioner on the D.C. Commission on Asian Pacific Islander Affairs, and co-founded and co-chairs the D.C. Asian American and Pacific Islander (AAPI) Democratic Caucus.
Wylie received a Bachelor of Science in Planning, Public Policy and Management, with minors in Women's Studies and Business Administration from the University of Oregon, and earned a Master of Education in Administration, Planning and Social Policy from Harvard Graduate School of Education. In addition to soccer, Wylie enjoys running, rock climbing and softball, and is an avid Oregon Ducks fan. He resides in Washington, D.C. with his wife, Marian Fowler.


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Based on 18 guest reviews
Property Location
Super 8 Floresville is located in Floresville.
Make yourself at home in one of the 40 air-conditioned rooms featuring kitchens with refrigerators and microwaves. Complimentary wireless Internet access keeps you connected, and flat-screen televisions are provided for your entertainment. Conveniences include desks and complimentary newspapers, as well as phones with free local calls.
Rec, Spa, Premium Amenities
Make use of convenient amenities, which include complimentary wireless Internet access and tour/ticket assistance.
A complimentary continental breakfast is included.
Business, Other Amenities
Featured amenities include a business center, a computer station, and dry cleaning/laundry services. Free self parking is available onsite.
The Super 8 highlights above are subject to change without notice.


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Dennis Ronaldo DeLeon Sr., 61, of Kailua-Kona and Lahaina, Maui, died April 21 at Kona Community Hospital. Born in Kealakekua, he was a retired security officer for Napili Kai Resort on Maui, former bus driver for City and County of Honolulu, Roberts of Hawaii and Dollar Rent A Car, and truck driver for Maui Pineapple Company. Celebration of life 9 a.m.-noon Saturday at Solid Rock Ministries Kona. Service at 10:30 a.m. Scattering of ashes 2 p.m. at Kamoa Point (Lyman's Beach). Loose flowers welcome. Maui celebration of life 10 a.m. Saturday, May 18, at Wahikuli Beach Park in Lahaina. Service at 11 a.m. Scattering of ashes to follow. Loose flowers welcome at both services. For information on both services, call (808) 268-1789. Survived by wife, Clare DeLeon of Lahaina; daughter, Denise (Andy) Alavazo of Lahaina; sons, Dennis (Tweet) DeLeon Jr. of Honolulu, Robert (Charity) DeLeon and Justin (Summer) DeLeon of Kailua-Kona; mother, Julia Luat of Kealakekua; brothers, Stephen (Alberta) Duarte of Pukalani, Maui, John (Joanna) De Leon of Hilo, Earl De Leon of Kainaliu, Richard (Karen) De Leon of Kihei, Maui, Chris (Evelyn) De Leon of Kealakekua, Ben De Leon of Maui; sister, Sylvia Simpson of Tennessee; stepmother, Erline De Leon of Kailua-Kona; 17 grandchildren; nieces and nephews. Arrangements by Cremation Services of West Hawaii.
Shigeru "Shige" Fujimoto, 88, of Honokaa died April 11 at Hale Ho'ola Hamakua. Born in Laupahoehoe, he was a retired journeyman welder for the former Hamakua Sugar Co., retired Honokaa Judo Club and Honokaa Aikido Club instructor, World War II veteran of U.S. Army, Co. B, 100th Battalion, 442nd Infantry Regiment, Hawaii Army National Guard retiree, former chairman of the ILWU Union Local 142, past-president of the ILWU Pension Club, and member of Honokaa Hongwanji Mission Kyodan and Wednesday Night Mixed Bowling League in Kona, and former County Planning and Liquor commissioner. Visitation 1-2 p.m. Monday at Dodo Mortuary Chapel. Memorial service at 2. Casual attire; no flowers. Survived by wife, Fujie "Jean" Fujimoto of Honokaa; sons, Scott (Dorothy) Fujimoto and Wesley (Audrey) Fujimoto of Honokaa, Stanley Fujimoto of Colorado; brother, Akira Fujimoto of Hilo; sisters-in-law, Tamae (Robert) Iwamoto of Honokaa and Harumi (Joseph) De Mello of Makakilo, Oahu; six grandchildren and one great-granddaughter; nieces and nephews. Arrangements by Dodo Mortuary.
Albert Lauro, 74, of Waipahu, Oahu, died April 13 at home. Born in Paauilo, he was a retired carpenter and Hawaii Army National Guard veteran. Visitation 8-10 a.m. Saturday at Pahoa Sacred Heart Catholic Church. Memorial Mass at 10 a.m. Casual attire; lei welcome. Scattering of ashes to follow. Survived by daughters, Roxanne (Derrick) Kamelamela of Pahoa, Angela (Douglas) Kealoha and Alberta Lauro of Las Vegas; son, Albert (Jody) Lauro, Jr. of Kaloli; brothers, David (Jean) Lauro of Kaloli, Joseph (Julie) Lauro of Pepeekeo and Daniel (Nina) Lauro of Kaneohe, Oahu; sisters, Lorraine Yadao of Kohala, Violet Bueno of Honokaa, Linda (Arnold) Tengan and Sally (Robert) Visaya of Hilo; hanai sister, Sophie Aiona of Pahoa; 11 grandchildren and nine great-grandchildren; cousins, nieces and nephews. Arrangements by Dodo Mortuary.
Teodorico D. "Chief" "Ekong" Mendoza, 88, of Pepeekeo, died April 24 at Hilo Medical Center. Born in Santa Maria, Ilocos Sur, Philippines, he was a retired crane operator for the Hilo Coast Processing Co., worked for Hakalau Sugar Plantation and was a member of the Pepeekeo Senior Citizens, ILWU Pepeekeo Pension Club, Retired Seniors Volunteer Program (RSVP) and Immaculate Heart of Mary Catholic Church in Papaikou. Visitation 5-9 p.m. Sunday, May 5 at Dodo Mortuary Chapel. Wake service at 7 p.m. Visitation again 9-10 a.m. Monday at the Immaculate Heart of Mary Catholic Church in Papaikou. Mass at 10 a.m. Casual attire. Burial to follow at Alae Cemetery. Survived by sons, Teodorico "Tidi" (Lorraine) Mendoza Jr., Randall Mendoza and Clay Mendoza of Pepeekeo, Duane (Judith) Mendoza of Hilo, Benjamin (Brenda) Mendoza of Kona and Paul (Lei) Mendoza of Pahoa; brothers, Isabel (Petra) Mendoza, Ernesto (Francisca) Mendoza, Fedencio (Leonida) Mendoza and Rudy Mendoza of Philippines; 19 grandchildren, 22 great-grandchildren and one great-great grandchild; nieces and nephews. Arrangements by Dodo Mortuary.
Robert M. Rankin, 87, of Kapoho, died April 23. Born in California, he was a retired poodle groomer. Graveside service and burial at noon today at Hawaii State Veterans Cemetery No. 2 in Hilo. Survived by his wife, Lillian Porter of Kapoho; son, Kirk Rankin of Arkansas. Arrangements by Borthwick Hawaii Funeral Home.
Ernest Silva was also known as "Outlaw". That information was omitted from an obituary published Tuesday.


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A.W.E - Awakening with Epstein
This limited enrollment experiential weekend offers a three-day journey to AWE-wakening using the Epstein technologies, including elements of his newest energetic applications! Donny Epstein will personally work on and with individuals in attendance to provide an experience of "core essence" and a deeper knowing and participation in the larger circle of life. Here the magnificence and wizardry of Epstein's work will be dedicated to working with your "Energy Houses" and "Orientating Rays of Consciousness" to facilitate "exchange" to a more energized and resourceful version of you.
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Click to Learn More about the Application and Selection Process for Premier Programs with Donny Epstein
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An intimate 3-day experiential program with Donny Epstein utilizing the Epstein Technologies, including elements of his newest energetic applications.
Seminar Administrated by Wise World Seminars Australasia Pty Ltd
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Its working. I'm actually starting to forget what actually happened. My lies are becoming truth in my head....is this damaging for the future do you think? Ah well, I don't care, its good for now. I decided I don't want to talk about the truth. I'm over it now....its been pushed away.
I really want to go talk to a therapist again. I just don't want anyone in my family to know. Problems are that I can't pay for it myself, I don't know who to go to and the ones that are free are not very good....I tried going to them already. They just really don't seem to give a shit. I try to talk to my friends, but I don't want to unload my problems onto them, they have their own to deal with. I also wouldn't want someone I hang around with knowing absolutely everything about me.....it might freak them out. I don't know what to do. I find I'm letting out more of my secrets though. I just can't contain them anymore, but I really don't want the people I tell to know, I just can't keep them in.
I'm changing so much right now and in the past two years.....I don't think I'm changing into something I want to be though. I don't know how to stop it!
I'm sorry your feeling so down right now,it sucks.I think the past affects how we behave in the present,so as regarding your question about lies affecting your future its up to you if you want them to.The future hasn't happened yet so you still have the power to change it if you want to.
I know what you mean about not being able to talk to friends about stuff, my friends have no idea of most of the craziness that goes on in my head.You say you want to see a therapist but can't afford it,how about visiting your doctor and talking about how you feel?It would be confidential and he/she might be able to give you some advice.Well I hope this helped you a bit,and feel free to message me anytime you want if you want to get anything off your mind.
It sounds like you really need someone to vent to. Keep talking till someone will listen. A true friend will care enough to listen to you.
No one has a right to sit down and feel hopeless; there is too much work to do.--Dorothy Day


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25 Free Craft Projects for Every Crafter - The Ultimate Craft Guide
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FaveCrafts Most Popular Craft Projects: February 2011
By: Karisa Tell, Editor for FaveCrafts.com
Check out this list of the most popular craft projects on FaveCrafts, AllFreeCrochet, AllFreeKnitting, and AllFreeSewing for February 2011. Revisit your faves and discover new projects to make!
FaveCrafts Most Popular Craft Projects: February 2011
Table of Contents
Craft Projects
Here are your favorite craft projects from February and a few bonus projects to make, hand selected based on your interests.
- Fat Quarter Dress: Free pillowcase dress patterns are all the rage on the internet these days. This pillowcase dress pattern uses coordinating fat quarters (front, back and trim). The dress will fits size 2T through 6.
If you like this project, check out more pillowcase projects to make:
Girl's Ruffle Dress & Two Pillowcase Blouse
- Easy Errands Bag:Crochet a handy rectangular bag with easy knotted handles for daily errands. The stripes in this bag are created by self-striping yarn instead of having to switch yarn balls.
If you like this project, check out more reusable grocery bags to make:
Recycled Produce Bag & Eco-Friendly Market Bag
- Oatmeal Container Yarn Holder:Turn an ordinary oatmeal container (or similar sized container) into a pretty yarn holder. This makes a quick and thrifty Mother's Day gift for a mom who crochets or knits.
If you like this project, check out more crafty storage ideas:
Yarn Storage Box & Water Bottle Storage Upcycle
Free Knitting Patterns
We rounded up your favorite knitting patterns from AllFreeKnitting.com and added in some extras from FaveCrafts. Enjoy!
- Dragon Skin Wrap or Scarf:Use this tutorial to create a beautiful Dragon Skin Wrap. You won't believe how elegant this pattern looks in person!
If you like this project, check out more scarves and wraps to knit:
Chevron Scarf & Coral Ruffle Wrap
- Stained Glass Ripple Afghan: Spice up your bed or couch with this gorgeous free knitting pattern. The Stained Glass Ripple Afghan is the type of pattern that makes a great gift and will receive many compliments.
If you like this project, check out more afghans to make:
Stained Glass Motif Afghan (crochet) & Knit Ripple Blanket
- Flamboyant Scarf:Free knitting patterns for scarves don't have to be boring! Create this fun and funky Flamboyant Scarf to add some pizazz to your outfits.
If you like this project, check out more scarves to knit:
Diagonal Baktus Lace Scarf & Makin' Bacon Scarf
Free Crochet Patterns
Grab your hooks and start crocheting! Here are your favorite patterns from AllFreeCrochet.com, plus more from FaveCrafts that we know you'll love.
- Soccasins: Moccasins or Socks? Now you don't have to choose! These soccasins look like adorable winter boots for the indoors. The best part? You can make them in a variety of styles and colors!
If you like this project, check out more slippers to make:
Warm Boot Slippers (knit) & Pom Pom Slippers (crochet)
- Spider Stitch Throw: Crochet yourself this luxurious Spider Stitch Throw! Spider Stitch is a technique that creates the illusion of a spider's web.
If you like this project, check out more afghans to make:
Arrow Stitch Afghan (crochet) & Pillar Stitch Afghan (knit)
- Particulary Pink Dishcloth: Use this free crochet pattern to make a pretty in pink dishcloth. The different colors truly make this a fun pattern to make.
If you like this project, check out more dishcloths to crochet:
Cheerful Dishcloth & Springtime Cloth
Free Sewing Patterns
Here are the top 3 most popular sewing patterns from AllFreeSewing.com. To find more sewing patterns on FaveCrafts, read on...
- Pleated Apron with Built In Hot Pads: You won't believe how nifty this project is. The name says it all - the Pleated Apron with Built in Hot Pads is really useful. It's no ordinary apron because with this cool sewing project, you won't be searching for hot pads!
If you like this project, check out more aprons to sew:
Quick Pillowcase Apron & Reversible Scrap Fabric Apron
- Scrappy Needle Keeper: Looking for a way to use up some of your fabric scraps? Here's a great project that calls for small amounts of fabric you already have in your craft collection. Follow the Scrappy Needle Keeper Tutorial.
If you like this project, check out more needle and hook storage ideas:
Case for Crochet Hooks & Felt Flower Pin Cushion
- Tattered Flowers for Embellishment: Use this free sewing pattern to add a touch of spring to everything! These tattered button flowers can be added to bags, headbands, shirts or even skirts. Get creative, there are tons of possibilities!
If you like this project, check out more fabric flowers to make:
No-Sew Flower Bouquet & Mod Podge Flower Pin
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19:15 02 March 2015
The first model of a zombie epidemic to use real US census data lets you choose where the plague begins and how fast it spreads
18:16 02 March 2015
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Gaia Herbs Quick Defense, Liquid-Filled Capsules
20.0 ea
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Ship to you only - {{productModel.rebateText}}
- Provides quick response at onset of symptoms
- Supports the body's response to immune stressors
- Supports respiratory resistancemore
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Not sold in stores
A Dietary Supplement
Quick Response at Onset
Quick Defense® is an exclusive formula designed to quickly support the body's immune response during times of challenge*.
- 100% Vegetarian
- Certified Organic Grower
- Certified Organic Processor
- Whole Plant Standardization
- Tested Free of Heavy Metal Toxicity
- Contains No Animal By-Products and No Gelatin
A Blend of Modern Science and Traditional Herbal Solutions
Quick Defense® is a proprietary, synergistic formula that features the most respected and beneficial herbal choices for immune reaction support. Simple and effective, it contains four key components:
- Echinacea Rx-A Factors - highly concentrated Alkylamides from Echinacea roots that are highly equipped to support the body's response to immune stressors*
- Black Elderberry - supports respiratory resistance through the promotion of free-radical quenching antioxidants in the fruit extract*
- Andgrographis - a "cooling" herb, traditionally used to reestablish tissue integrity*
- Ginger root - a "warming" herb, well known for its ability to promote wellness of the mucous membranes in the sinus cavity and respiratory system*
This blend of scientifically-researched Echinacea with antioxidant-rich traditional herbs delivers powerful support for the body's response to challenges that trigger our immune systems.
Quick Defense® is designed to be fast-acting when dosing starts at onset and needs to be taken for only 2-4 days.
Ground-breaking Research on Echinacea!
Through 5 years of federally funded research, Gaia Herbs had identified key chemical differences in Echinacea that have a huge impact on efficacy. Quick Defense® is based on the discovery of how Alkylamides found in the roots of certain species of Echinacea offer the most effective support for the body's immune response to seasonal triggers.
Proprietary Manufacturing
Gaia Herbs developed a proprietary, patent-pending method for extracting and concentrating the highly active Alkylamide factors from Echinacea - that we call Rx-A Factors. We grow the Echinacea used for the Quick Defense® formula at our farm under certified organic conditions and are the only U.S. manufacturer extracting Echinacea for the important Alkylamide factors.
Quick Defense® - Up to 5 Times More Alkylamides than other leading brands!
Comparison Amounts of Echinacea Alkylamides per Company
- Company A = .06 mg
- Company B = .33 mg
- Company C = .38 mg
- Gaia Herbs Quick Defense = 5.0 mg
Manufactured by Gaia Herbs in our Oregon Tilth Certified Organic Processing Facilities
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Take 2 capsules, 5 times daily for 2 days, starting at onset. Repeat for 2 more days if necessary
©Gaia Herbs, Inc.
Shipping Weight (in lbs): 0.27 Product in inches (LxWxH): 2.0x 1.95x 3.6
Item Code: 252764
Vegetable Glycerin , Olive Oil (Certified Organic) , Chlorophyll Vegetable Cellulosecapsule
Nutrition Facts | ||
Serving Size : 2 Capsules Serving per Container : 10 |
Amount Per Serving | % Daily value* | |
Water 543 mg | ||
Echinacea Pupurea (Coneflower) Root 250 mg | ||
Echinacea Angustifolia (Coneflower) Root Extract 83 mg | ||
Proprietary Synergistic Blend: 210 mg | ||
Water | ||
Water | ||
Ginger Root Extract | ||
Water 5200 mg | ||
Calories 14 Calories |


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3Doodler Announces Retail Plans
(3Ders.org) 3Doodler, the $99 handheld 3D printer, has announced worldwide plans to go into retail outlets in 2014 as well as launching a range of accessories. 3Doodler will be available across the US at Brookstone's retail stores, as well as online with website ThinkGeek, Maker Shed and the MoMA Store, 3Doodler's official launch partner for design. 3Doodler will also be launching six different changeable nozzles, allowing users to extrude plastic in different shapes and sizes. The 3Doodler, which debuted last year following a massive crowdfunding campaign on Kickstarter, has almost finished shipping Kickstarter backers their 3D-printing pen.


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Kay and Lewis Brown wanted some quick cash so they could make a moderate addition to their home. They turned to CashCall, an online loan service, after seeing the ads on TV. The company lent them $5,000 — at 59% interest. Now the couple is on the hook for $20,830.
Sallie Mae is going to "reverse outsource" and move 2,000 jobs from overseas back to the US in order to get people, (the president?) to like them again. Will it work? HAHAHHAHAHA. Oh, sorry. That was unprofessional. [Reuters]
House Preparing To Legalize Payday Loans With 391% APRs
A House subcommittee wants to legalize payday loans with interest rates of up to 391%. Lobbyists from the payday industry bought Congress' support by showering influential members, including Chairman Luiz Gutierrez, with campaign cash. The Congressman is now playing good cop, bad cop with the payday industry, which is pretending to oppose his generous gift of a bill.
Mortgage rates are at a record low of 4.78%, according to Freddie Mac. [Bloomberg]
A Big-Ass List Of Student Loan Resources
It's a tough economic climate to be graduating from school — and maybe an even tougher one for those of you trying to get financial aid. We've put together a list of some financial aid and student lending resources to help make things easier.
Battle Of The Most Hated Companies: Countrywide Sues AIG
Last year's Worst Company in America winner, Countrywide Home Loans, has sued AIG for not paying their claim on losses from failed real estate loans that they had insured with the company.
Top 10 States For Mortgage Fraud
As you might imagine, mortgage fraud is up, up, up. 26%!
1 In 8 US Households Either Late Or In Foreclosure
Here's your daily depressing mortgage news — as employers shed jobs mortgage delinquencies are rising — intensifying and spreading the mortgage crisis.
Looking for a mortgage? You might want to consider an FHA loan. The New York Times says, "The Federal Housing Administration used to be known as a place for low-income borrowers with tarnished credit histories. But now, it has become a destination for borrowers whose credentials are respectable, but not stellar." [NYT]
Meet The Savings & Loan That Destroyed Wachovia
60 Minutes recently took a look at World Savings Bank, the acquisition that ultimately wounded Wachovia so badly that it had to be acquired by Wells Fargo. What was wrong with an institution for which Wachovia was willing to pay $25 billion? Well, one whistleblower claims that World Savings was engaged in fraud and predatory lending — tricking its customers into signing up for dangerous "option-arm" or (as they cheerfully called them) "pick-a-payment" loans.
Make The Bank Prove It Really Owns Your Mortgage Before You Let Them Toss You Out
We've written about this before, but as more and more people face foreclosure (last year's foreclosures totaled 2.3 million, according to the AP) its a good time to remind people of this strategy.
Treasury Secretary Timothy Geithner has announced a new website, financialstability.gov, to increase transparency in the financial stability program.
Faces Of Foreclosure: The Nonagenarian (He's 92.)
Our sister publication, Consumer Reports, put together some video interviews with people who, for one reason or another, are facing foreclosure. They are the human side of this financial meltdown.
Fannie Mae Relaxes Standards For Refinancing
Bloomberg says that Fannie Mae will loosen standards for refinancing in the hopes that more homeowners will be able to take advantage of historically low interest rates.
9 In 10 Executives At Bailed-Out Banks Kept Their Jobs
Over 100,000 people have been laid off by banks, but 9 in 10 executives at banks that accepted bailout money are still working says the Associated Press.
Here's a resource to help you determine whether your library lends digital media such as audiobooks and ebooks. It also helps you locate other libraries that offer digital lending. [Overdrive] (Thanks to jojo319!)
Auto Title Loans, Illegal In Most States, Even Riskier In Georgia
Meet Scott. When builders in financial trouble stopped paying him the money he was owed as a brick and stone contractor, he became desperate. He needed a loan to buy him time while he tried to collect the money he was owed. Thinking he understood the risks, he used his wife's 2004 Ford Expedition to get an auto title loan of $2,000 at an interest rate of 25% per month — or 300% APR.


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Alden wingtip bluchers on the Plaza last. These are built with Alden's Flex Welt where the soles were soaked in special oils to make them more sturdy and comfortable.
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SAS International is a British manufacturer of interior products, meeting the ever increasing demands of clients and specifiers worldwide.
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MEDFORD, Ore. — Joshua Majchrzak graduated from high school last year and is now working toward his dream. "Right now I'm just doing my pre-requisites at R.C.C. but eventually I plan on going into nanotechnology which is a new field in science," said Majchrzak. The road to that career will include higher education and the … Continue reading »
Rogue Creamery Now a "Benefit Company"
MEDFORD, Ore. — Local cheese shop Rogue Creamery is the first business in the state to earn a new title for social responsibility. The shop is now one of 29 companies registered as a benefit company, a new business type created this year by the Oregon House. Benefit companies are a way for businesses to … Continue reading »
Logging Protest Bills Pass Oregon House
SALEM, Ore. — Protesters who chain themselves to trees and block roads, interfering with logging operations, may soon face stiffer penalties. The Oregon House has passed two bills targeting those protesters. A first offense would be a misdemeanor and subsequent offenses would be felonies. The other bill would allow logging companies to sue demonstrators who … Continue reading »
"Good Neighbor Bill" Passes House
SALEM, Ore. — Legislation has passed in the Oregon House to prevent vacant foreclosed homes from becoming neighborhood eyesores. More than half of all foreclosed homes in Oregon are vacant, but current law does not assign responsibility for the upkeep of these abandoned properties. This situation has created problems for neighborhoods throughout the state as … Continue reading »
"Popular Vote" Proposal In Oregon
SALEM, Ore. — The Oregon House has voted to join a movement seeking to elect the president by the national popular vote. The legislation would require Oregon to cast its seven electoral college ballots for the candidate who wins the national vote, rather than the one who gets the most votes in Oregon. Nine states … Continue reading »
Bill Proposes Pot Grow Restrictions
MEDFORD, Ore. — Local law enforcement is backing a bill to change Oregon's Medical Marijuana Program. The bill is pushing to limit how many growers are allowed to grow medicinal cannabis on any one property. Medford Police Chief Tim George was in Salem to support House Bill 3055. He testified at a hearing at the … Continue reading »
Oregon Voting On Immigrant Tuition Bill
SALEM, Ore. — A bill allowing illegal immigrants to pay in-state tuition could be voted on by the full Oregon House this Friday. The bill was approved by a House committee on Monday. Currently, Oregon state universities make students pay out-of-state tuition if they cannot prove they are in the U.S. legally. The bill's supporters … Continue reading »


text: What is the best gran .45 hollow point to use for self defense. I just bought my first .45 and I was looking at Remington 230gr JHP. I know about federal hydro shock 185gr JHPs, but the Remington are less expensive. You can get 100 rounds for 37 bucks any thoughts on the Remington ammo for SD.


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Extracting Relevant Information from FDA Drug Files to Create a Structurally Diverse Drug Database Using KnowItAll®
Sponsored Links
Each Food and Drug Administration (FDA) consumer drug information file contains an inordinate amount of useful chemical, pharmaceutical, and pharmacological data. These files profile approved drugs by chemical structure, solubility, absorption, distribution, metabolism, elimination, toxicity (ADME/Tox), and possible adverse reactions. The ability to utilize this data in the classroom is a new approach to connect theory, technology, and reality. The KnowItAll® Informatics System available through Bio-Rad Laboratories, Philadelphia, PA , offers fully integrated software and/or database desktop solutions. It holds a large collection of in silico ADME/Tox predictors and is a chemical informatics platform used to record experimental data. This project had three goals: (1) extract relevant information for 75 drugs from their freely available FDA drug files (limited to orally administrated drugs, pro-drugs, having a chemical structure), (2) build a database so this extracted FDA information is indexed for search and analysis, and when completed, (3) undergraduates involved in such a project should be capable of harvesting useful chemical, pharmaceutical, and pharmacological information; be adept in computational chemistry software tools; and should gain an enhanced vocabulary and new insights into organic chemistry, molecular biology, and physiology.
Keywords: FDA consumer drug database©, KnowItAll®, ADME/Tox, (quantitative) structure activity relationship (Q)SAR, predictor tools, chemical informatics.
FDA consumer drug information files [1] provide open access to clinical data, including data from negative trials, and unpublished results. These portable document format (pdf) files profile drugs by chemical structure, solubility, metabolism pathways, absorption, distribution, elimination, carcinogenesis, mutagenesis, impairment of fertility, possible adverse reactions, and other useful pharmacokinetic, and toxicological data. Additionally, the searchable drug information database Drugs@FDA [2] serves as the most comprehensive resource for product specific information on drugs approved in the USA, and can be navigated using online text query with ease. However these documents are not consumer friendly and are very wordy. Furthermore, the often complex drug structures that are reported in the pdf drug files cannot be exported into another application. The FDA web-site also include findings from documents submitted voluntarily to the FDA Safety Information and Adverse Reporting program (MedWatch) [3] by the drug and biologic manufacturers, consumers, distributors, packers, and sponsors and from investigators with studies [3, 4] under the Investigational New Drug (IND) applications. Another very recent exhaustive resource serving the life science community is the University of Alberta's DrugBank database [5]. One goal is to provide science majors with a process that overcomes the initial fear that they may experience when attempting to extract useful information from this mass of files, as all of the above browseable high-quality mass of data can be mined, analyzed, and interpreted to develop statistical models of predictive quantitative and qualitative structure activity relationships (QSARs, SARs) [6-8].
Bio-Rad's KnowItAll® Informatics System Desktop Solutions [9] offers fully integrated software and/or database desktop solutions for multiple aspects of research including in silico ADME/Tox profiling, spectroscopy, cheminformatics, and medicinal chemistry [10]. The Company offers several KnowItAll® "editions" that combine the appropriate set of software tools based on specific user groups/needs [9-12]. In this article we detail steps that combine information freely accessed through the web along with our KnowItAll® Cheminformatics Edition [9] and our KnowItAll® ADME/Tox Edition [9] purchased through Bio-Rad Laboratories, in a project to teach students within an established Directed Research Program methods to access, extract, document, and manage relevant data from FDA drug files in order to create a searchable consumer drug database.
In order to create a mindset that would entail both qualitative and quantitative analyses, we undertook our project in two stages: (1) extract information for 75 consumer drugs from the FDA Drug Information Websites (limited to orally administrated drugs, pro-drugs, having a chemical structure) [1-4]; and (2) build a pharmaceutical database using our ADME/Tox edition and our Cheminformatics edition of the KnowItAll® System [9].
Here, data was extracted from the freely available FDA consumer drug information files [1-4] for the following 75 randomly chosen unrelated consumer drugs: Iressa®, Levitra®, Strattera®, Abilify®, Inspra®, Hepsera®, Namenda®, Alinia®, Emtriva®, Emend®, Tindamax®, Sensipar®, Pletal®, Viagra®, Zavesca®, Orfadin®, Zyvox®, Uroxatral®, Zelnorm®, Avodart®, Frova®, Provigil®, Aromasin®, Detrol®, Thalomid®, Atacand®, Zonegran®, Micardis®, Maxalt®, Xeloda®, Arava®, Gleevec®, Cialis®, Reyataz®, 5FU from of Xeloda®, Cardesartan (active metabolite of Xeloda®), Hectoral®, Singulair®, Spectracef®, Cefaditoren (active metabolite of Specfracef®), Sanctura®, Colazal®, active metabolite of Arava®, Zetia®, Hepsera® M1, Spiriva®, Starlix®, Tasmar®, Xifaxan®, Crestor®, Nolvadex®, Detrol® M1, Mobic®, Sustiva®, Aciphex®, Ziagen®, Protonix®, Celebrex®, Agenerase®, Trileptal®, OxcarbazepineMHD (active metabolite of trileptal®), Exelon®, Temodar®, Keppra®, Tequin®, Avandia®, Actos®, Avelox®, Tamiflu®, Oseltamivir Carboxylate (active metabolite of Tamiflu®), Lopinavir®, Ritonavir®, Benicar®, Rapamune®, and Ketek®. The three dimensional chemical structure for each of the 75 drugs was drawn using the DrawItTM drawing application available in the KnowItAll® Cheminformatics Edition [9]. For prodrugs, chemical structures of both the prodrugs and their corresponding real drugs were drawn and dealt with separately (for example Detrol® and Detrol M1).
KnowItAll® Cheminformatics solutions [9] include tools to draw, modify, store, search, name, and retrieve chemical structures. Notably, their structure drawing and reporting tools are based on the well-respected ChemWindow technology and are designed so that chemists can recognize stereochemistry, E/Z isomers, and contains chemical recognition features such as, hot keys, chemical syntax checker, tools to calculate mass and formula, etc. A recent comparison [13] of current freely available commercial chemical software drawing and reporting tools, gave the applications from the KnowItAll® Academic Edition a very high rating for its quality, flexibility, and ease of use.
Figure 1. Chemical structure of Tamiflu® obtained using the DrawItTM application in the KnowItAll® Cheminformatics Edition
Figure 1 shows the chemical structure of the drug Tamiflu® drawn using the DrawItTM application in the KnowItAll® Cheminformatics Edition. This structure is documented in Tamiflu's® FDA drug profile [1] where it is reported with a non-systematic International Union of Pure and Applied Chemistry (IUPAC) nomenclature of (3R,4R,5S)-4-acetylamino-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid, ethyl ester, phosphate (1:1). An advantage of the KnowItAll®
Figure 2. IUPAC name of Tamiflu® obtained using the IUPAC NameItTM application in the KnowItAll® Cheminformatics Edition
Figure 3. 3D structure of Tamiflu® obtained using the 3D ViewItTM application in the KnowItAll® Cheminformatics Edition
Cheminformatics Edition is that it is bundled with the IUPAC NameItTM application, which has the capability to generate a compound's correct systematic IUPAC name from its structure. In this case (as shown in Figure 2) the IUPAC NameItTM application reported, ethyl (5S,3R,4R)-4-(acetylamino)-5-amino-3-(ethylpropoxy) cyclohex-1-enecarboxylate, phosphoric acid, for Tamiflu®. This ensures the accuracy in the recording, storage, and the retrieval of chemical information for the drug that often has significant text information content associated with its systematic name in the literature.
The 3D ViewItTM application also bundled in the KnowItAll® Cheminformatics edition has the ability to covert the 2D DrawItTM image of Tamiflu® into realistic 3D drawings as shown in Figure 3. This ability to work with such high resolution images can serve as an inexpensive and powerful method to study structure based drug design.
Since FDA drug structures cannot be imported directly from the drug file into KnowItAll®, one has to redraw the often complex drug structure using correct stereochemistry and geometry. An example is shown below using the structure of the immunosuppressant Rapamune®. A slight error in the drawing (like not connecting the highlighted double bond as shown in Figure 4), can have a significant impact during any future mining and screening process [14]. Such an error can be avoided when using the KnowItAll® Cheminformatics Edition, due to the presence of a 'Check Chemistry' tool which highlights possible connectivity errors, and a 'Calculate Mass & Composition' tool that provides the structure's molecular weight (MWt), molecular formula, and chemical composition; these can be then compared for accuracy with the data reported for these parameters in the drugs FDA files [1-4] (Figures 4 & 5). Storage of accurate structures within a database has been shown to be crucial especially when querying the database by structural criteria or substructure search [14, 15].
Figure 4. Incorrect drawing of Rapamune® Figure 5. Correct drawing of Rapamune®
MWt: 930.23; Formula: C52H83NO13 MWt: 914.19; Formula: C51H79NO13
KnowItAll® also logically integrates all applications in a single interface (Figure 6) so the user can easily transfer information from application to application without opening another program [9]. For example, one can draw a structure, send it to a module for NMR prediction, and then add that structure to a user database. Tools are also available to correlate whether or not a structure matches a spectrum, and the SearchItTM application [9] allows structures and/or spectra to be imported and searched against reference databases, as well as against user created databases.
Figure 6. Single interface applications [9] in the KnowItAll® Cheminformatics Edition
The company's website also reports that the KnowItAll® in silico ADME/Tox solutions can be used to assess a potential drug's ADME/Tox profile with over 30 predictive models and tools for model building and validation [9]. These applications in the KnowItAll® ADME/Tox edition allows researchers to build predictive SAR models of biological properties using databases of compounds with known property values and molecular indices calculated from their chemical structure [9, 16-20]. We purchased fourteen pharmaceutical and pharmacological parameters and these were packaged in our KnowItAll® ADME/Tox edition. These parameters are common to traditional (Q)SAR modeling and each parameter value was then extracted (when reported) from each drug profile. The fourteen pharmaceutical and pharmacological properties were Oncogenicity, Teratogenicity, Mutagenicity, Human Intestinal Absorption, Plasma Protein Binding, Water Solubility, Volume of Distribution, Elimination Half Time, Rate of Absorption, Blood Brain Barrier, NeuroToxicity, pKa, Bioavailability, and log P. In cases where experimental values were not available, missing properties from some drug profiles were calculated with the available predictor tools [9] within the KnowItAll® platform.
Since the published FDA drug profiles [1-4] for these structurally diverse consumer drugs come from different pharmaceutical companies, there are major differences in the reporting of a set of properties provided for each drug profile. Therefore for some of the drugs, before using their reported information in the pharmaceutical and pharmacological data content section of their FDA files, data normalizations were sometimes needed. An example here is for the pharmacokinetic parameter Volume of Distribution; for Micardis® (which is a combination of telmisartan, an orally active angiotensin II antagonist acting on the AT1 receptor subtype, and hydrochlorothiazide, a diuretic), the FDA file reports: "The Volume of Distribution for telmisartan is approximately 500 liters indicating additional tissue binding." In our KnowItAll® database, for Micardis®, Volume of Distribution is normalized to 7.14 L/kg. This was done by dividing the reported volume by 70 kg which is the average weight of the human subjects in a majority of the documented FDA file data. Sometimes, wide ranges of data had to be inputted into KnowItAll®. For example, the Rapamune® FDA label file reports: "The mean volume of distribution (Vss/F) of sirolimus (the international nonproprietary name for Rapamune®) is 12 ± 8 L/kg." Hence, its KnowItAll® database Volume of Distribution is documented as 4 ~ 20 L/kg. Sometimes data interpretations had to be made; as in the case of pharmaceutical formulation parameter, Water Solubility: approximations of sparingly, slightly soluble => 0.001 – 0.01 mg/ml; very, freely, or highly soluble => 1000 mg/ml, were made. For example, the Crestor® FDA label file reads: "Rosuvastatin calcium (active ingredient) is a white amorphous powder that is sparingly soluble in water and methanol, and slightly soluble in ethanol." Hence, the KnowItAll® database Water Solubility value for Crestor® is documented as 0.001 mg/ml.
Figure 7. FDA Consumer Drug database© created using the KnowItAll® ADME/Tox Edition
On evaluating each of the chosen 75 FDA consumer drug profiles, we redrew the three dimensional chemical structures for each of the 75 drugs using the DrawItTM drawing application available in the KnowItAll® Cheminformatics Edition; harvested information about each drugs trade (patent) name, classification, and associated chemical data; documented available information for all fourteen pharmaceutical and pharmacological parameters; and then, with the database building capability of Bio-Rad's KnowItAll® platform, created a FDA Consumer Drug Database© as shown in Figure 7. This database is now available [21] through Bio-Rad Laboratories, and it should help increase the accuracy of predictions by contributing to the variation of available models [22]. Going forward, there is the potential to use this database [21] to extract SAR patterns (example shown below) across these structurally diverse and unrelated 75 consumer drugs. Results from such a task will be presented in the near future [23].
In order to investigate structure activity relationships (SAR) of sulfur-containing functional groups (sulfide, sulfamoyl, sulfonyl, and sulfone); the sulfur-containing functional group is first drawn using the DrawItTM tool in KnowItAll®, then the SearchItTM tool is utilized to search the FDA Consumer Drug Database© for the maximum hits for that functional group, sorting among the 75 drugs. However SearchItTM results reports some drugs several times (within the 4 sulfur-containing functional groups), not because they contain more than one functional group, but simply because of a common chemical structural motif, such as S=O, shared between the 4 sulfur-containing functional groups. Hence, a visual sorting needs to be done. On completion, the ChemSilico predictions [9] can be made for each of the 75 drugs using the KnowItAll® predictor ProfileItTM as represented in the Figure 8 below, and the required biological property data can be extracted from these predictions.
Figure 8. ProfileItTM prediction results for Tindamax® (a synthetic antiprotozoal and antibacterial agent).
FDA Drug Information data files [1-4] contain valuable chemical, pharmaceutical and pharmacological data. However at times, this data needs normalization as it is expressed in wide ranges. The consistency to optimize compounds for multiple attributes (simultaneously) with experimental data in certain areas, should also encourage students working on such a project to make the connections between chemistry, biology, and physiology. The KnowItAll® platforms ease-of-operation, availability of analysis, interpretation, and reporting tools, coupled with the ability to build searchable databases seamlessly integrated within a single user interface, is ideally suited for cheminformatics applications at research institutions. This system offers an ideal environment for researchers to analyze and compare experimental results across a diverse collection of drugs including the potential to study structure activity relationship (SAR) patterns.
This research was supported by grant number 2 P2O RR016472-08 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). This IDeA Network of Biomedical Research Excellence (INBRE) grant to the state of Delaware was obtained under the leadership of the Delaware Biotechnology Institute, University of Delaware , and the authors sincerely appreciate their efforts.
References and Notes
§Fumie Koyoshi was a Wesley College Biology major who completed this project during an INBRE supported Undergraduate Research Assistantship in the Directed Research Program in Chemistry at Wesley College. On graduation, she joined the University of Pennsylvania Hospital, School of edical Technology, Philadelphia, PA.
1.Food and Drug Administration (FDA) profiles. Retrieved from http://www.fda.gov/cder/drug/default.htm
2.Drugs@FDA. Retrieved from http://www.accessdata.fda.gov/Scripts/cder/DrugsatFDA/
3. FDA Safety Information and Adverse Reporting program (MedWatch). Retrieved from http://www.fda.gov/medwatch/
4.NIH Molecular Libraries-Small Molecule Repository. Retrieved from http://mlsmr.glpg.com/MLSMR_HomePage/submitcompounds.html
5.Wishart, D. S.; Knox, C.; Guo, A. C.; Shrivastava, S.; Hassanali, M.; Stothard, P.; Chang, Z.; Woolsey, J. DrugBank: A Comprehensive Resource for In Silico Drug Discovery and Exploration, Nucleic Acid Research 2006, 34 (Database Issue), D668-D672.
6.Kruhlak, N. L.; Contrera, J. F.; Benz, R. D.; Matthews, E. J. Progress in QSAR Toxicity Screening of Pharmaceutical Impurities and Other FDA Regulated Products, Advanced Drug Delivery Reviews 2007, 59(1), 43-55.
7.Cronin, M. T. D.; Jaworska, J. S.; Walker, J. D.; Comber, M. H. I.; Watts, C. D.; Worth, A. P. Use of QSARs in International Decision-Making Frameworks to Predict Health Effects of Chemical Substances, Environmental Health Perspectives 2003, 111(10), 1391-1401.
8.Walker, J. D.; Jaworska, J.; Comber, M. H. I.; Schultz, T. W. Dearden, J. C. Guidelines for Developing and Using Quantitative Structure Activity Relationships, Environmental Toxicology and Chemistry 2003, 22(8), 1653-1665.
9.KnowItAll® Informatics System Desktop Solutions. Retrieved from http://www.knowitall.com/
10. D'Souza, M. J. KnowItAll® - Software Reviews, Chemistry World, 2005, 2(9), 70-71.
11. KnowItAll® U System. Retrieved from http://www.knowitallu.com/
12. D'Souza, M. J. KnowItAll® U System - Software Reviews, Chemistry World, 2007, 4(11), 70-72
13. Anand, V.; Gera, M.; Kumar, V.; Karwasara, P.; Kataria, M.; Kukkar, V. Comparative Evaluation of Freely Available Chemical Structure Drawing Software, Pharmaceutical Rev. 2008, 6(2), ISSN 1918-5561.
14. Richard, A. M.; Swirsky Gold, L.; Nicklaus, M. C. Chemical Structure Indexing of Toxicity Data on the Internet: Moving Toward a Flat World, Current Opinion in Drug Discovery & Development, 2006, 9(3), 314-325.
15. Baumgras, J. L.; Rogers, A. E. Chemical Structures at the Desktop: Integrating Drawing Tools with on-line Registry Files, Journal of the American Society for Information Science 1999, 46(8), 623-631.
16. D'Souza, M. L.; Abshear, T.; Banik, G. M.; Nedwed, K.; Peng, C. A Model Validation and Consensus Building Environment, SAR and QSAR in Environmental Research 2006, 17(3), 311-321.
17. Banik, G. M. In Silico ADME/Tox Prediction: The More, the Merrier, Current Drug Discovery, 2004, 31-34.
18. Dearden, J.; Worth, A. In Silico Prediction of Physicochemical Properties, JRC Scientific and Technical Reports, EUR 23051, EN-2007, 1-68.
19. Bidault, Y. A Flexible Approach for Optimizing In Silico ADME/Tox Characterization of Lead Candidates, Expert Opinion on Drug Metabolism and Toxicity 2006, 2(1), 157-168.
20. Dearden, J. C. In Silico Predictions of ADMET Properties: How Far Have We Come? Expert Opinion on Drug Metabolism and Toxicity 2007, 3(5), 635-639.
21. D'Souza, M. J. FDA Consumer Drug database – 2007. HaveItAll - ADME/Tox Experimental Databases Datasheet, Bio-Rad Laboratories, Bulletin # INF-96199, 2008.
22. Wess, G. How to Escape the Bottleneck of Medicinal Chemistry, Drug Discovery Today, 2002, 7(10), 533-535.
23. D'Souza, M. J.; Koyoshi, F.; Everett, L. M. Structure Activity Relationship (SAR) Patterns Observed Within a Series of Unrelated Common Consumer Drugs, 2009 International Conference on Bioinformatics, Computational Biology, Genomics, and Chemoinformatics (BCBGC-09), Orlando, FL, USA (2009).
About Authors:
Malcolm J. D'Souza , Fumie Koyoshi
Malcolm J. D'Souza
Dr. Malcolm J. D'Souza is Professor of Chemistry at Wesley College, in Dover, Delaware. He has published over 50 peer-reviewed journal articles, and has established a nationally recognized Wesley College Undergraduate Directed Research Program in Chemistry. 26 undergraduates are co-authors on his publications, and 6 Wesley College undergraduate research posters from his laboratory earned national recognition. Recently, the Delaware American Chemical Society (DE-ACS) nominated Dr. D'Souza to the 2008 E. Emmett Reid Award for Excellence in Teaching at a Small College. Dr. D'Souza has received 3 teaching awards, a faculty research award, and currently serves as Guest Editor for a peer-reviewed journal. His current research efforts in bio-organic chemistry are supported by grant number 2 P2O RR016472-08 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). This IDeA Network of Biomedical Research Excellence (INBRE) grant to the state of Delaware was obtained under the leadership of the Delaware Biotechnology Institute (DBI), University of Delaware.
Fumie Koyoshi
Fumie Koyoshi (B.S. Biology, 2008) graduated at the top of her class at Wesley College. She earned several scholarships and honors, including the Wesley College Faculty Award given to the most outstanding student in the 2008 graduating class. Outcomes from her Wesley College undergraduate research work were published as 4 refereed articles, and two of her poster presentations earned Certificates of Recognition when presented at National American Chemical Society Conferences. On graduation, Ms. Koyoshi joined the University of Pennsylvania Hospital, School of Medical Technology, in Philadelphia, Pennsylvania.
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text:
Vice President Joe Biden Set To Visit 'On Air with Ryan Seacrest'
Over the years Ryan Seacrest has had the privilege of interviewing several major political figures including: President Barack Obama, First Lady Michelle Obama, Secretary of State Hillary Clinton, Former President Bill Clinton, Mayor of Los Angeles Antonio Villaraigosa and Former Senator Ted Kennedy.
On Monday, January 23, "On Air with Ryan Seacrest" will welcome special guest Vice President of the United States Joe Biden.
At 7:00am PST, the Vice President will join the top-rated, Los Angeles morning drive radio show to answer questions from college students submitted via Ryan's Facebook page.
Watch First Lady Michelle Obama Send Her First Tweet [VIDEO]
The Vice President has been touring the nation holding Town Hall meetings in an effort to discuss the administration's efforts to educate students on how to make college more affordable and student debt more manageable. The Vice President told students in Florida, "A college education is almost a prerequisite or a ticket to the middle class. It's also a prerequisite if we're going to lead this world again."
President Obama Talks To Ryan About Date Nights with Mrs. Obama [AUDIO]
Are you a struggling student with a question for the Vice President? Do have questions about the economy, jobs, or financial aid? The Vice President wants to hear from you!
Ask Vice President Joe Biden A Question!


text: The liberal arts degree with a single major in Music, referred to as Track 1, has been constructed primarily for students who have a strong interest in music and who desire a broad liberal arts education. This major, available under the Bachelor of Arts degree, strives to develop students who are both academically and musically trained and to prepare them for graduate study, if that is their goal, or to choose from a variety of careers following graduation. The objectives of the major include the development of a broad base of information about music history and music theory through comprehensive instruction in these areas. The major prescribes a minimum of 48 semester hours in music courses.


text:
Its that first week of March, I thought I would take time and give a couple of reasons why I am excited about March:
1. The NCAA Basketball Tournaments start! These Gents play for the love of the game and I love this game! ( with that said I used to play sports as well as a cheerleader in HS and college. )
2. Spring is coming! The birdies are gonna chirp and the flowers bloom and this confounded snow will melt!
3. St. Patty's day- Green Beer and Black n' Tans. Best part …my Creme de Menthe cupcakes. Yumm-o and a Lime Gimmlet Martini
4. Mustache and Mullets !? Priceless =)
Ok… let me elaborate. It is 2 months until graduation at the college I am attending. Some guys are dubbing this mustache and mullet March. They are growing out their mustaches and their hair until the end of march. At the end of March, they are going to groom their staches and get their mullets did. They then will proceed to the nearest sears portrait studio and get their senior pics taken wearing fanned shirts. (complete with a fat wiener dog which will be included in these epic shots) I find this hilarious and yet wonder if anyone else would do that? I heart mustaches because they remind me of Yosamity Sam and they make great art pieces ( Im working on a print myself).
Tell me what you think? Would you do the mustache/ mullet March challenge? How would you grow out yo stache? Handlebar, The Chevron,The Dali, English, Fu Manch, or perhaps an Imperial mustache? OR a fingerstache?


text:
Ingersoll Rand 2475N7.5-P Stationary Air Compressor
Ingersoll Rand 2475N7.5-P 7.5HP 3PH 460V Stationary Air Compressor
- Premium Package: See includes tab for details
- Designed for the most demanding automotive, heavy-duty commercial or industrial applications
- Durable cast-iron construction
- Automatic start/stop control/pressure switch operation
- 175 PSI maximum operating pressure
- 7.5 HP, 80 gallon vertical tank
- Low oil protection switch to prevent the pump from running dry
- Electronic drain valve that automatically drains water from compressor tank
The 2475N7.5-P includes:
- One (1) 7.5HP 3PH 460V 80 Gallon Stationary Vertical Air Compressor
- 100% Cast Iron Pump
- ASME Coded Receiver Tank
- NEMA 1 & ODP Motor
- Mounted Motor Starter
- Automatic Start/Stop Control through Pressure Switch
- Vibration Isolators (Available with Purchase of Installation Kit)
- Electric Drain
- Air Cooled Aftercooler
- Low Oil Level Switch
Tech Specs:
- Brand: Ingersoll-Rand
- Horsepower: 7.5
- Tank Capacity: 80
- Input Voltage: 460
- Configuration: Vertical
- Maximum Working Pressure (psi): 175.000
- Cubic Feet per Minute: 24.00
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Having problems with your electric Air Compressor?
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text:
What you guys think will be in the next Droid 4 I'm thinking quad core processor 2 to 3 ghz. 2gb of ram 4.3 to 5 inch screen size 8 to 10 megapixel camera and latest Android software. I would love this phone. Probably come out in August of 2012 Sent from my ADR6350 using DroidForums
I really wish this would come out by Christmas. I had the og droid and now the d2 and would like to keep it going with the droid 4 but i really want a new phone for Christmas and it doesnt look like the droid 4 is going to make it. I guess its the razr for me. Liberated D2
The general consensus is that it has a 4" screen, 1.2 GHz dual-core OMAP4 4430 processor, 4G LTE connectivity, a slide-out QWERTY keyboard. I havent heard about the other specs. Sent from my DROID3 using DroidForums
Droid 4 Yup will definitely have 4G LTE I wish I bought a 4G phone now though Sent from my ADR6350 using DroidForums
You think it will have a smaller screen I doubt it 4.3 is becoming the standard size for cell phones Sent from my Droid Incredible 2 using Droid Forums
It was confirmed to have a 4" screen here... http://www.howardforums.com/showthr...4-quot-Maserati-quot-Pre-Release-Thread/page7 ...the Droid RAZR has a 4.3" screen. Sent from my DROID3 using DroidForums
Droidlife has confirmed the rest of the specs... looks like it will have a removable battery. Sent from my DROID3 using DroidForums
Correction, it does have a removable back cover, but not a removable battery... weird. Sent from my DROID3 using DroidForums
Just a heads up I made a Pre-Release thread here: http://www.droidforums.net/forum/droid-4/184408-official-df-droid-4-pre-release-thread.html
It looks like the specs have been leaked for the Droid 4 I guess the phone will be coming out earlier then expected with these types of specs. Sent from my Droid Incredible 2 using Droid Forums


text:
DC LIGHTER RECEPTACLE INLINE Cigarette Lighter Receptacle, In-line socket, Current Rating: 5 A, Features: Without fuse, DC plugs for use in mobile applications
Works well and as intended. It's not super solid, though, so I wouldn't expect it to withstand day-to-day connects and disconnects. Mine is pretty much used as a permanent connection, so I expect it to last a long time. No complaints.
12V receptacle has a good solid plastic body and threads very nicely. Tabs are somewhat flimsy but if soldered as intended are as durable as one could expect. Used daily as a hard-wire option for satellite radio install and perform great. No problems with connectivity or durability. I recommend this product.
Login Here to rate and review this product.
28-10570 - Four Outlet Cigarette Lighter Adapter - 12V DC Plug
Convert your DC outlet to four outlets Includes 10A fuse Cord length 4' Available with 12VDC plug or tinned leads for permanent installation
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27-610 - DC Lighter Plug 3A Fuse
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29-4275 - AA NiMH Rechargeable Battery 2300MAh
Best Uses: NiMH rechargeable batteries are perfect for Toys, Remotes, Games and other high tech devices Initial charge: MCM's rechargeable batteries must be fully charged before using. Usually an overnight charge is sufficient. However because they are not fu...
21-3300 - Powerpole Modular Connectors
Powerpole connectors provide reliability, flexibility and convenience. Each Powerpole connector is a genderless, single connector half of which can be dovetailed together to create customized connectors. Popular connector used for RC cars and ideal for automotive ...
MCM Cat 57, Page 823
MCM Cat 56, Page 736


text:
"Two are better than one, Because they have a good reward for their labor. For if they fall, one will lift up his companion. But woe to him who is alone when he falls, For he has no one to help him up. Again, if two lie down together, they will keep warm; But how can one be warm alone? Though one may be overpowered by another, two can withstand him. And a threefold cord is not quickly broken." Ecclesiastes 4:9-12
The Couples' Ministry at Calvary Chapel Chino Valley encourages couples to worship, pray, study the Word, and serve the Lord together. The ministry's goals are:
- To provide questions and topics that will provoke discussions about the current study.
- To establish small group interaction of what the Lord is revealing out of His Word and its application in our marriages.
- To provide an environment for Christian couples to worship and fellowship together in Christ.
- To make marriages stronger in the Lord and to bring glory to God.
Mission Statement:
The Couples' Ministry at Calvary Chapel of the Chino Valley believes the Bible is the inspired and inerrant Word of God that provides all the direction necessary to understand God's will for our lives and our marriages. We believe God has ordained marriage and Jesus Christ must be the cornerstone of our relationship with our spouse.
Ministry Vision:
By providing small group study of God's word, fellowship opportunities, our vision is to provide an environment where marriages may grow into the union God purposed it to be.
Ministry Purpose:
The purpose for the Couples' Ministry is to strengthen couples' relationships with God and each other by providing opportunities to worship, pray, study the Word of God and serve the Lord together.
If you have questions about the Couples' Ministry, please call the church office at 909-464-8255 ex.256 or you may email us at email@example.com.
Please visit us on Facebook at CCCV Couples' Ministry. If you would like to register for the monthly Couples' Ministry eBulletin click here.
Couples' Conference
Join us for our upcoming Couples' Conference, A Time to Love, on Saturday, February 14th from 9am-12pm. Pastor David Rosales will be speaking, along with Pastor David Guzik from Calvary Chapel Santa Barbara. Open to all married, engaged, and dating couples. Cost is $20 per couple.
Coffee will be served in the courtyard at 8:00am. Our café will be open from 8-9:00 if you'd like to purchase a breakfast sandwich, baked goods or a latte. Sanctuary doors open at 8:30am.
This is a non-refundable event. Childcare is not provided.
Register at the Gazebo, CCCV front desk or online. This is a non-refundable event. We will also have same-day registration from 8-9am at the gazebo, before the conference begins.


text:
A 3D horror movie set in a public toilet block is part of a revolution underway in the Asian film industry as low-budget 3D productions take on the big studios at their own game.
At the 16th Busan International Film Festival (BIFF), audiences have been lining up to see the likes of multi-million dollar 3D productions "The Three Musketeers" and the re-imaged version of the local monster hit "The Host".
But there?s also been a groundswell of support for two debut features that use the same cutting edge digital technology to help entertain at a fraction of the price. …
"When I first started thinking about making a 3D film I thought about all the special effects but I wanted to use it to exaggerate what people are seeing in more normal situations and to then blur the lines between fantasy and reality," said the director.
Park said 3D technology was a format more independent filmmakers were exploring, even though in the beginning they might have to work through a process of trial and error.
"At the moment, for small filmmakers, we don?t have a lot of knowledge about how 3D films are made," said Park. "You have to figure it out for yourself. I spent nine months in post-production and I never really turned my computer off. I had to solve all the problems myself.
"But this is my first 3D feature so I knew I had to take everything on — and 3D is becoming more and more a part of the film medium." …
See the full story here: http://www.google.com/hostednews/afp/article/ALeqM5gt_NrKcFgN6TvwYmwBmS6BrDKyqA?docId=CNG.d58991fb87f986aa56a63cf0993e348c.331


text:
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In most sexually reproducing organisms, meiotic recombination is initiated by DNA double-strand breaks (DSBs) formed by the Spo11 protein. In budding yeast, nine other proteins are also required for DSB formation, but the roles of these proteins and the interactions among them are poorly understood. We report further studies of the behaviors of these proteins. Consistent with other studies, we find that Mei4 and Rec114 bind to chromosomes from leptonema through early pachynema. Both proteins showed only limited colocalization with the meiotic cohesin subunit Rec8, suggesting that Mei4 and Rec114 associated preferentially with chromatin loops. Rec114 localization was independent of other DSB factors, but Mei4 localization was strongly dependent on Rec114 and Mer2. Systematic deletion analysis identified protein regions important for a previously described two-hybrid interaction between Mei4 and Rec114. We also report functional characterization of a previously misannotated 5' coding exon of REC102. Sequences encoded in this exon are essential for DSB formation and for Rec102 interaction with Rec104, Spo11, Rec114, and Mei4. Finally, we also examined genetic requirements for a set of previously described two-hybrid interactions that can be detected only when the reporter strain is induced to enter meiosis. This analysis reveals new functional dependencies for interactions among the DSB proteins. Taken together, these studies support the view that Mei4, Rec114, and Mer2 make up a functional subgroup that is distinct from other subgroups of the DSB proteins: Spo11-Ski8, Rec102-Rec104, and Mre11-Rad50-Xrs2. These studies also suggest that an essential function of Rec102 and Rec104 is to connect Mei4 and Rec114 to Spo11.
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Probably! Or, maybe! Or… my hair looks funny today. Ever since Gerard Butler told Katherine Heigl in The Ugly Truth that men all love long hair we've wondered "really?" Brace yourself, the following investigative research indicates that The Ugly Truth may not be 100% factually accurate (although still more accurate than we'd like).
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