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From Wikipedia, the free encyclopedia - View original article
Systematic (IUPAC) name | |
2-(2-(4-dibenzo[b,f][1,4]thiazepine- 11-yl- 1-piperazinyl)ethoxy)ethanol | |
Clinical data | |
Trade names | Seroquel |
AHFS/Drugs.com | monograph |
MedlinePlus | a698019 |
Licence data | US FDA:link |
Pregnancy cat. | B3 (AU) C (US) |
Legal status | Prescription Only (S4) (AU) POM (UK) ℞-only (US) |
Routes | Oral |
Pharmacokinetic data | |
Bioavailability | 100%[1] |
Protein binding | 83%[2] |
Metabolism | Hepatic via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[3] |
Half-life | 7 hours (parent compound); 9-12 hours (active metabolite, norquetiapine)[2][4] |
Excretion | Renal (73%), faeces (20%)[1][2][4][5] |
Identifiers | |
CAS number | 111974-69-7 |
ATC code | N05AH04 |
PubChem | CID 5002 |
IUPHAR ligand | 50 |
DrugBank | DB01224 |
ChemSpider | 4827 |
ChEBI | CHEBI:8707 |
ChEMBL | CHEMBL716 |
Chemical data | |
Formula | C21H25N3O2S |
Mol. mass | 383.5099 g/mol |
| |
| |
Physical data | |
Solubility in water | 3.29 mg/mL (20 °C) |
(what is this?) (verify) |
Systematic (IUPAC) name | |
2-(2-(4-dibenzo[b,f][1,4]thiazepine- 11-yl- 1-piperazinyl)ethoxy)ethanol | |
Clinical data | |
Trade names | Seroquel |
AHFS/Drugs.com | monograph |
MedlinePlus | a698019 |
Licence data | US FDA:link |
Pregnancy cat. | B3 (AU) C (US) |
Legal status | Prescription Only (S4) (AU) POM (UK) ℞-only (US) |
Routes | Oral |
Pharmacokinetic data | |
Bioavailability | 100%[1] |
Protein binding | 83%[2] |
Metabolism | Hepatic via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[3] |
Half-life | 7 hours (parent compound); 9-12 hours (active metabolite, norquetiapine)[2][4] |
Excretion | Renal (73%), faeces (20%)[1][2][4][5] |
Identifiers | |
CAS number | 111974-69-7 |
ATC code | N05AH04 |
PubChem | CID 5002 |
IUPHAR ligand | 50 |
DrugBank | DB01224 |
ChemSpider | 4827 |
ChEBI | CHEBI:8707 |
ChEMBL | CHEMBL716 |
Chemical data | |
Formula | C21H25N3O2S |
Mol. mass | 383.5099 g/mol |
| |
| |
Physical data | |
Solubility in water | 3.29 mg/mL (20 °C) |
(what is this?) (verify) |
Quetiapine (/kwɨˈtaɪ.əpiːn/ kwi-TY-ə-peen) (branded as Seroquel, Xeroquel, Ketipinor) is a short-acting atypical antipsychotic approved for the treatment of schizophrenia, bipolar disorder, and along with an antidepressant to treat major depressive disorder.
Annual sales are approximately $5.7 billion worldwide, with $2.9 billion in the United States.[6] The U.S. patent,[7] which was set to expire in 2011, received a pediatric exclusivity extension which pushed its expiration to March 26, 2012.[6][8] The patent has already expired in Canada. Quetiapine was developed by AstraZeneca from 1992-1996 as an improvement from first generation antipsychotics. It was first approved by the FDA in 1997. There are now several generic versions of quetiapine, such as Quepin, Syquel and Ketipinor.[9]
Quetiapine fumarate is primarily used to treat schizophrenia or bipolar disorder.[10]
There is tentative evidence of the benefit of quetiapine versus placebo in schizophrenia; however, definitive conclusions are not possible due to the high rate of attrition in trials (greater than 50%) and the lack of data on economic outcomes, social functioning, or quality of life.[11]
It is debatable whether, as a class, typical or atypical antipsychotics are more effective.[12] Both have equal drop-out and symptom relapse rates when typicals are used at low to moderate dosages.[13] While quetiapine has lower rates of extrapyramidal side effects, there is greater sleepiness and rates of dry mouth.[11]
In those with bipolar disorder, quetiapine is used to treat depressive episodes, acute manic episodes associated with bipolar I disorder (as either monotherapy or adjunct therapy to lithium, valproate or lamotrigine), and maintenance treatment of bipolar I disorder (as adjunct therapy to lithium or divalproex).[14][15]
Quetiapine is effective when used by itself[16] and when used along with other medications in major depressive disorder (MDD).[16][17] However, sedation is often an undesirable side effect.[16]
In the US,[4] the UK[18] and Australia (in this indication it isn't covered by the Pharmaceutical Benefits Scheme), quetiapine is licensed for use as an adjunct in the treatment of MDD.[19]
Quetiapine does not decrease agitation among people with Alzheimer's, whose usage of the drug once constituted 29% of sales. Quetiapine worsens intellectual functioning in the elderly with dementia and therefore is not recommended.[20]
The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[21][22]
It is sometimes used off-label, often as an augmentation agent, to treat conditions such as Tourette syndrome,[23] musical hallucinations[24] and anxiety disorders.[25]
Quetiapine and clozapine are the most widely used medications for the treatment of Parkinson's disease psychosis due to their very low extrapyramidal side effect liability. Owing to the risks associated with clozapine (e.g. agranulocytosis, diabetes mellitus, etc.), clinicians often attempt treatment with quetiapine first, although the evidence to support quetiapine's use for this indication is significantly weaker than that of clozapine.[26][27]
Sources for incidence lists:[1][4][18][19][27][28]
There is an emerging controversy regarding quetiapine fatalities. The deaths of at least six U.S. military veterans who were given drug cocktails including quetiapine[31] have been attributed to its inclusion by military doctors to treat PTSD. Approximately 10,000[32] lawsuits[33][34][35][36][37] against AstraZeneca for problems ranging from slurred speech and chronic insomnia to death have been filed by individuals from civilian populations.
It is marketed as one of the most sedating of all anti-psychotics, although those claims are contested.[38] Beginning users may feel extremely tired and 'out of it' for the first few days, and sometimes longer. Quetiapine's newest indication, for bipolar depression, usually specifically calls for the entire dose to be taken before bedtime due to its sedative effects. The sedative effects may disappear after some time on the drug, or with a change of dosage, and with possibly different, non-sedative side-effects emerging.
Both typical and atypical antipsychotics can cause tardive dyskinesia.[39] According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%.[39] Although Quetiapine and Clozapine are atypical antipsychotics, switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals.[40]
Weight gain can be a problem for some, with quetiapine causing more weight gain than fluphenazine, haloperidol, loxapine, molindone, olanzapine, pimozide, risperidone, thioridazine, thiothixene, trifluoperazine, and ziprasidone, but less than chlorpromazine, clozapine, perphenazine, and sertindole.[41]
Studies conducted on beagles have resulted in the formation of cataracts. While there are reports of cataracts occurring in humans, controlled studies including thousands of patients have not demonstrated a clear causal association between quetiapine therapy and this side-effect.[citation needed] However, the Seroquel website[42] still recommends users have eye examinations every six months.
As with some other anti-psychotics, quetiapine may lower the seizure threshold,[43] and should be taken with caution in combination with drugs such as bupropion.
A recent comparative study of anti-psychotics drugs has found that quetiapine mono treatment was associated with increased risk of death relative to the other analyzed treatments (but still better than no anti-psychotics drug treatment at all).[44]
Quetiapine should be discontinued gradually, with careful consideration from the prescribing doctor, to avoid withdrawal symptoms or relapse.
The British National Formulary recommends a gradual withdrawal when discontinuing anti-psychotic treatment to avoid acute withdrawal syndrome or rapid relapse.[45] Due to compensatory changes at dopamine, serotonin, adrenergic and histamine receptor sites in the central nervous system, withdrawal symptoms can occur during abrupt or over-rapid reduction in dosage. However, despite increasing demand for safe and effective antipsychotic withdrawal protocols or dose-reduction schedules, no specific guidelines with proven safety and efficacy are currently available.
Withdrawal symptoms reported to occur after discontinuation of antipsychotics include nausea, emesis, lightheadedness, diaphoresis, dyskinesia, orthostatic hypotension, tachycardia, insomnia, nervousness, dizziness, headache, excessive non-stop crying, and anxiety.[46][47] According to Eli Lilly internal documents, discontinuation of atypical neuroleptics similar to seroquel can also cause psoriasis, gingivitis and other inflammatory conditions, dyspepsia, headache, high blood sugar and other health conditions unrelated to psychiatric condition.[1][2] Some have argued that additional somatic and psychiatric symptoms associated with dopaminergic super-sensitivity, including dyskinesia and acute psychosis, are common features of withdrawal in individuals treated with neuroleptics.[48][49][50][51] This has led some to suggest that the withdrawal process might itself be psychosis-mimetic, producing psychotic-like symptoms even in previously healthy patients, indicating a possible pharmacological origin of mental illness in a yet unknown percentage of patients currently and previously treated with antipsychotics. This question is unresolved, and remains a highly controversial issue among professionals in the medical and mental health communities, as well the public.[52]
Most instances of acute overdosage result only in sedation, hypotension and tachycardia, but cardiac arrythmia, coma and death have occurred in adults. Serum or plasma quetiapine concentrations are usually in the 1–10 mg/L range in overdose survivors, while postmortem blood levels of 10–25 mg/L are generally observed in fatal cases.[53]
Placental exposure is least for quetiapine compared to other atypical antipsychotics.[27] The evidence is insufficient to rule out any risk to the foetus but available data suggests it is unlikely to result in any major foetal malformations.[2][5][28] It is secreted in breast milk and hence quetiapine-treated mothers are advised not to breastfeed.[2][5][28]
Receptor | Quetiapine (Cloned human receptors) | Norquetiapine (Cloned human receptors) |
D1 | 994.5 | 99.8 (Rat receptor) |
α1A | 22 | 144 |
α1B | 14.6 | 46.4 (Rat receptor) |
α2A | 3630 | 237 |
α2C | 28.85 | - |
M1 | 489 | 38.3 (Rat receptor) |
Quetiapine has the following pharmacological actions:[58][59][60][61]
This means Quetiapine is a dopamine, serotonin, and adrenergic antagonist, and a potent antihistamine with clinically negligible anticholinergic properties. Quetiapine binds strongly to serotonin receptors; the drug acts as partial agonist at 5-HT1A receptors.[62] Serial PET scans evaluating the D2 receptor occupancy of quetiapine have demonstrated that quetiapine very rapidly disassociates from the D2 receptor.[63] Theoretically, this allows for normal physiological surges of dopamine to elicit normal effects in areas such as the nigrostriatal and tuberoinfundibular pathways, thus minimizing the risk of side-effects such as pseudo-parkinsonism as well as elevations in prolactin.[64] Some of the antagonized receptors (serotonin, norepinephrine) are actually autoreceptors whose blockade tends to increase the release of neurotransmitters.
The synthesis of quetiapine begins with a dibenzothiazepinone. The lactam is first treated with phosphoryl chloride to produce a dibenzothiazepine. A nucleophilic substitution is used to introduce the sidechain.[65]
At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker. When the dose is increased, quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. At high doses, quetiapine starts blocking significant amounts of dopamine receptors.[66][67] Use of low-dose quetiapine is not recommended except temporarily during drug titration period (less than 30 days).[68]
Due to compensatory changes at dopamine, serotonin, adrenergic and histamine receptor sites in the central nervous system, a gradual reduction in dosage is recommended to minimise or avoid withdrawal symptoms. Withdrawal symptoms reported to occur after discontinuation of quetiapine include insomnia, nausea, emesis, lightheadedness, diaphoresis, orthostatic hypotension, tachycardia, as well as nervousness, dizziness, headache, and anxiety. The present evidence suggests that these symptoms affect a small number of susceptible individuals treated with quetiapine.[46]
The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotic treatment to avoid acute withdrawal syndrome or rapid relapse.[45]
AstraZeneca submitted a new drug application for a sustained-release version of quetiapine in the United States, Canada, and the European Union in the second half of 2006 for treatment of schizophrenia.[69][70] AstraZeneca will retain the exclusive right to market sustained-release quetiapine until 2017. The sustained-release quetiapine is marketed mainly as Seroquel XR. Other marketing names are Seroquel Prolong and Seroquel Depot.
On May 18, 2007, AstraZeneca announced that the U.S. FDA approved Seroquel XR for acute treatment of schizophrenia.[71] During its 2007 Q2 earnings conference, AstraZeneca announced plans to launch Seroquel XR in the U.S. during August 2007.[72] However, Seroquel XR has become available in U.S. pharmacies only after the FDA approved Seroquel XR for use as maintenance treatment for schizophrenia, in addition to acute treatment of the illness, on November 16, 2007.[73] The company has not provided a reason for the delay of Seroquel XR's launch.
Health Canada approved sale of Seroquel XR on September 27, 2007.[74]
The FDA approved Seroquel XR for the treatment of bipolar depression and bipolar mania in early October 2008. According to AstraZeneca, Seroquel XR is "the first medication approved by the FDA for the once-daily acute treatment of both depressive and manic episodes associated with bipolar."
On July 31, 2008, Handa Pharmaceuticals, based in Fremont, California, announced that its abbreviated new drug application ("ANDA") for quetiapine fumarate extended-release tablets, the generic version of AstraZeneca's SEROQUEL XR, has been accepted by the FDA.
On December 1, 2008, Biovail announced that the FDA had accepted the company's ANDA to market its own version of sustained-release quetiapine.[75] Biovail's sustained-release tablets will compete with AstraZeneca's Seroquel XR.
On December 24, 2008, AstraZeneca notified shareholders that the FDA had asked for additional information on the company's application to expand the use of sustained-release quetiapine for treatment of depression.[76]
In the United States, the Food and Drug Administration (FDA) has approved quetiapine for the treatment of schizophrenia and of acute manic episodes associated with bipolar disorder (bipolar mania) and for treatment of bipolar depression.[77] In 2009, quetiapine XR was approved as adjunctive treatment of major depressive disorder.[78]
Quetiapine received its initial indication from U.S. FDA for treatment of schizophrenia in 1997.[79] In 2004, it received its second indication for the treatment of mania-associated bipolar disorder.[80] In 2007 and 2008, studies were conducted on quetiapine's efficacy in treating generalized anxiety disorder and major depression. In April 2009, the Psychopharmacologic Drugs Advisory Committee of the FDA held a public meeting to discuss whether study results supported the FDA's approval for anxiety and depression, with risks of metabolic side-effects and of tardive dyskinesia and sudden cardiac death.[81]
In April 2010, AstraZeneca settled a longstanding U. S. Department of Justice investigation into its aggressive marketing of Seroquel for such off-label uses with a $520-million fine.[77] According to the Department of Justice, "the company recruited doctors to serve as authors of articles that were ghostwritten by medical literature companies and about studies the doctors in question did not conduct. AstraZeneca then used those studies and articles as the basis for promotional messages about unapproved uses of Seroquel."[77]
Multiple lawsuits have been filed in relation to quetiapine's side-effects, in particular, diabetes.[82][83][84][85] In 2009, documents unsealed in litigation against AstraZeneca indicated that Dr. Charles Schulz, Chair of the Department of Psychiatry at the University of Minnesota and a consultant for AstraZeneca, had misrepresented the benefits of Seroquel in research presentations and press releases.[86]
AstraZeneca has been sued by the U.S. government (resulting from a qui tam lawsuit filed by Stefan P. Kruszewski) over the marketing of quetiapine. A $520-million settlement was reached on October 29, 2009.[87]
In 2004, a young man named Dan Markingson committed suicide in a controversial Seroquel clinical trial at the University of Minnesota while under an involuntary commitment order.[88] A group of University of Minnesota bioethicists charged that the trial involved an alarming number of ethical violations, but the university declined to investigate.[89] Quetiapine may have been a factor in the deaths of several US veterans who were taking large doses as part of a cocktail of drugs for PTSD.[relevant? ][90]
In Australia, Professor Patrick McGorry, a key mental-health advisor, proposed a trial in Melbourne in 2011. Its purpose was to investigate whether Seroquel would decrease or delay the risk that people aged between 15 and 40 with early signs of mental illness, might develop a later psychotic disorder. However in July 2011, psychiatrists, psychologists and researchers from Australia, New Zealand, Canada, Britain and the US lodged a complaint with the ethics committee of Melbourne Health. They opposed the trial[91] as "unethical" and "dangerous".
Quetiapine is not classified as a controlled substance; "abusive self-administration seems to be driven by quetiapine's sedative and anxiolytic effects (to help with sleep or to 'calm down') rather than by its antipsychotic properties."[92] Reports of quetiapine abuse have emerged in medical literature. In addition to oral administration, the drug is also taken intranasally by snorting pulverized tablets (insufflation). There have been reports of intravenous abuse and intravenous co-administration with cocaine as well.[93] This is commonly referred to as a "Q-Ball".[93] A 2004 letter to the editor of the American Journal of Psychiatry provided an anecdotal estimate that up to 30% of inmates who were seen for psychiatric services in the Los Angeles County Jail were faking psychotic symptoms in an attempt to obtain quetiapine.[94] Also known as "quell", "Snoozeberries", or "Susie-Q", the drug may be more commonly abused in prisons due to its capacity to be regularly prescribed as a sedative and the unavailability in prison of more commonly abused substances. A letter to the editor that appeared in the January 2007 American Journal of Psychiatry has proposed a "need for additional studies to explore the addiction-potential of quetiapine". The letter reports that its authors are physicians who work in the Ohio correctional system. They report that "prisoners ... have threatened legal action and even suicide when presented with discontinuation of quetiapine" and that they have "not seen similar drug-seeking behavior with other second-generation antipsychotics of comparable efficacy". It has also been reported that when Seroquel is used with methadone, it causes the user to experience a buzz, or opioid euphoria.[95]
In August 2011, the UK's Medicines and Healthcare products Regulatory Agency (MHRA) issued a class-4 drug alert following reports that some batches of Nurofen plus contained Seroquel XL instead.[96]
Following the issue of the Class-4 Drug Alert, Reckitt Benckiser (UK) Ltd received further reports of rogue blister strips in cartons of two additional batches of Nurofen Plus tablets. One of the new batches contained Seroquel XL 50 mg tablets and one contained the Pfizer product Neurontin 100 mg capsules.
Following discussions with the MHRA's Defective Medicines Report Centre (DMRC), Reckitt Benckiser (UK) Ltd decided to recall all remaining unexpired stock of Nurofen Plus tablets in any pack size, leading to a Class-1 Drug Alert.[97] The contamination was later traced to in-store tampering by a customer.[98]


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After all the controversy of 2007, the 07-08 winter break had been comparatively quiet. But while off-track reconciliation was certainly in the air between defending champions Ferrari and arch rivals McLaren, testing had suggested that both teams would still be tussling at the top of the heap when the season got underway.
As for their rivals, there had been fraught times for the formerly-Honda funded Super Aguri team as they waited for news of a buyer, and though their short-term future was secured just days before the Melbourne race, the team had managed next to no testing. BMW Sauber, Toyota, and occasionally Renault, however, had all tested well. And as the paddock made their way to Albert Park for the Australian Grand Prix, everything was in place for a knock-out 2008.
On the Friday Ferrari and McLaren were pretty evenly matched, with defending champion Kimi Raikkonen setting the fastest lap in the morning and Lewis Hamilton topping the afternoon timesheets. Despite his pace Raikkonen wasnt in high spirits, the Finn perhaps somehow aware that things were about to go downhill. Hamilton, by contrast, was confident, as was new team mate Heikki Kovalainen, fourth fastest. Red Bull too enjoyed a productive day thanks to second-placed Mark Webber, but Toyota struggled with tyre graining and Renaults Fernando Alonso bemoaned the stability of the R28 under braking.
Saturday practice was dominated by the BMW Saubers of Robert Kubica and Nick Heidfeld, with Alonso, Red Bulls David Coulthard and Williams Nico Rosberg all close behind. Ferraris Felipe Massa was only 11th, ahead of Hamilton, 12th, and Raikkonen, 14th, but their unconvincing form wasnt expected to last.
Hamiltons certainly didnt, the British driver grabbing pole to launch his 2009 campaign in the best way possible. Kubica was equally impressive in second, just ahead of Kovalainen. But for Ferrari it was a day to forget, with Raikkonen (16th) sidelined after fuel pump problems and Massa scrap on to the second row. Making up the top 10 were Heidfeld in fifth, ahead of Toyotas Jarno Trulli, Rosberg, Coulthard, Timo Glock and Toro Rossos Sebastian Vettel. Glock subsequently dropped 10 places after receiving two penalties, thereby lifting Hondas Rubens Barrichello into P10.
As the first race since the FIAs ban on traction control, the start was expected to be nail biting, but few forecast that the drama would be sustained to the finish line, with just six cars making it to the chequered flag and three teams on the podium.
As predicted, there was incident at the first corner, resulting in a safety-car period and retirement for Hondas Jenson Button, Force Indias Giancarlo Fisichella, Webber, Super Aguris Anthony Davidson and Vettel. But there was much more excitement to come, even though up front, eventual winner Hamilton was for the most part oblivious to the carnage behind. After his podium celebrations had died down he would later describe his MP4-24 as phenomenal.
After their poor qualifying, Ferrari found they were right in the middle of the action. Massa spun on the first lap and later collided with Coulthard before retiring with a blown engine. Raikkonen initially took advantage of a second safety car, but then went off the road trying to pass Kovalainen, and while running in seventh his F2008 ground to a halt with three laps to go. With both Ferrari engines succumbing, sporting director Luca Baldisserri labelled the race disastrous. The only solace was that the disqualification of seventh-placed Barrichello for exiting the pit under a red light meant Raikkonen was classified eighth and hence scored a solitary point.
For excellent qualifier Kubica there was misery too, after he retired with collision damage. It was left to team mate Heidfeld to show just what the F1.08 could do, taking an excellent second behind Hamilton. Third place was taken by Rosberg after a storming race for Williams, whose other runner Kazuki Nakajima finished sixth.
Nelson Piquets less-than-inspiring debut in the Renault ended in retirement, but team mate Alonso got the most out of the R29 to score fourth. Kovalainen finished less than a second down on the Spaniard, but could have taken second behind Hamilton had a heavy accident for Toyotas Glock not caused a third safety-car period, forcing the Finn to pit when the field had closed up.
While Kovalainen suffered from an ill-timed pit stop, another driver was able to capitalise. Debutant Sebastien Bourdais took on more fuel and tyres at just the right moment and moved up the field for Toro Rosso. And though his (Ferrari) engine subsequently gave up on the 56th lap, he was classified seventh.
With just the six runners remaining, it had been a race of extreme attrition. At the final reckoning Toro Rossos double DNF was matched by five other teams - Ferrari, Toyota, Red Bull, Force India and Super Aguri. Of those left standing, BMW Sauber, Williams and Renault had much to celebrate, but the Melbourne weekend belonged to McLaren.
Pole position, first and fifth places, the two fastest laps and 14 championship points represented a good, if not quite perfect start to the season. And after simultaneously silencing their critics and building a formidable title lead, the British team couldnt wait to journey to Malaysia.

subset: commoncrawl


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Pacific Pavingstone Image Gallery
Over the last decade, Pacific Pavingstone has been responsible for hundreds of stone installations throughout the Southern California region. From paver stone driveways to patios, walkways, and general landscape design, our talented team of craftsmen, laborers, and designers have worked together to create a wide variety of additions. No matter what our clients have demanded from us, Pacific Pavingstone has been able to meet those requests and surpass expectations time and time again.
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Overall increase is small, though, adding 1 cancer per 1,000 women treated
by Cfish on Tue Dec 06, 2005 12:00 AM
by Caregiverinnc on Wed Dec 21, 2005 12:00 AM
by Firstborn on Wed Feb 14, 2007 12:00 AM
I am also interested in info. on Advastin and BCNU for treatment of GBM stage 4. My father has undergone 2 resections in 3 years. After the first surgery he used Temador and Radiation for 1 year, no reoccurance for 8 months after treamtent ended. He had his 2nd resection in may 2006. Was put on BCNU and Phlimide, after 2 months 2 tumors were seen on MRI. He was then put on the combimation of Avastin and CPT11 for the past 4 months, shrinkage of tumors occured on the first MRI (2 months of treatment) then last MRI showed tumor growth of app. 1 cm. Now they are going to try Avastin and BCNU with a new MRI to be done next month. Does anyone have any info on the combination of BCNU and Avastin?? Would love to hear from you.
by kayakjack on Tue Jan 20, 2009 12:00 AM
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Work Exempted from permits are listed below for the following categories:
A. Exempted Work – Building
1. Single story detached accessory buildings used as tool and storage sheds, playhouses and similar uses, provided the projected roof area does not exceed 120 sq. ft. Consult with Planning for zoning requirements.
2. Fences not over 6 feet in height. Consult with Planning for zoning requirements.
3. Movable cases, counters and partitions not over 5', 9" in height.
4. Oil derricks.
5. Retaining walls, which are not over 4 feet in height, measured from the bottom of the footing to the top of the wall, unless supporting a surcharge or impounding Class I, II, or III-A liquids.
6. Water tanks supported directly upon grade if the capacity does not exceed 5,000 gallons and the ration of height to diameter or width does not exceed two to one. Consult with Planning for zoning requirements.
7. Platforms, walks, and driveways not more than 30" above grade and not over any basement or story below. Consult with Planning for zoning requirements.
8. Painting, papering, and similar finish work.
9. Temporary motion picture, television, and theater stage sets and scenery.
10. Window awnings supported by an exterior wall of Group R, Division 3, and Group M Occupancies when projecting not more than 54 inches.
11. Prefabricated swimming pools accessory to a single-family residence in which the pool walls are entirely above the adjacent grade and the capacity does not exceed 5,000 gallons. Consult with Planning for zoning requirements.
12. Light standards that do not exceed 30 feet in height.
13. Playground equipment.
B. Exempted Work - Electrical
1. Work as itemized in section 089-4 of the State Electrical Code
2. Minor repair work such as the replacement of lamps, switches, receptacle devices, sockets, taping bare joints and the like, or the connection of portable motor and appliances to suitable receptacles which have been permanently installed.
3. The wiring of temporary theater, motion picture, or television stage sets.
4. The repair or replacement of fixed motors, transformers, apparatus, or appliances of the same type and rating in the same location.
5. Electrical wiring, devices, appliances, apparatus, or equipment operating at less than 25 volts, and not capable of supplying more than 50 watts of energy.
6. Low-energy, control and signal circuits that are not an integral part of an appliance and in which the power is limited from a source having a rated output of not more than 30 volts and 1,000 volt-amperes.
7. Repair or replacement of overcurrent devices.
8. Private telephone, intercom, sound, and communication systems; provided however that a permit shall be obtained for the power supplies required by the above systems.
C. Exempt Work-Mechanical
1. A portable heating appliance, portable ventilating equipment, portable cooling unit or portable evaporative cooler.
2. A closed system of steam, hot or chilled water piping within heating or cooling equipment regulated by this code.
3. Replacement of any component part or assembly of an appliance, which does not alter its original approval and complies with other applicable requirements of this code.
4. Refrigerating equipment that is part of the equipment for which a permit has been issued pursuant to the requirements of this code.
5. A unit refrigerating system.
6. [For SFM} State-owned buildings under the jurisdiction of the state fire marshal.
D. Exempt Work-Plumbing
1. The stopping of leaks in drains, soil, waste or vent pipe.
Note: Should any concealed trap, drainpipe, soil, waste or vent pipe become defective and is necessary to remove and replace the same with new material, the same shall be considered as new work and a permit shall be procured and inspection made as provided in this Code.
2. The clearing of stoppages or the repairing of leaks in pipes, valves or fixtures.**
3. Water closet removal and reinstallation.**


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Premiere Date:Friday, June 27, 2008
On For The Record, lawyer Gibson Vance of the Montgomery Firm Beasley Allan will react to the U.S. Supreme Court decisions this week, including the one that ruled the punitive portion of the Exxon oil spill decision excessive. The journalist/panelists are Dana Beyerle, The New York Times Regional Newspapers and Kim Price, the Wetumpka Herald & The Eclectic Observer.


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Rob may be trying to hide from the paparazzi while in Adelaide, Australia, but a fan just gave away his location — against his wishes! See the pic.
Robert Pattinson is one hot commodity. The sexy Brit is busy filming The Rover in Australia, but he still manages to find time for his fans! Unfortunately, Rob's generosity may come back to bite him in the rear end!
Trance Tyler, a fan who ran into Rob while filming, tweeted a series of messages, saying, "Sitting on the footpath watching Robert Pattinson and his crew film his new film The Rover. Got pictures with Robert Pattinson, he was drinking a beer and we had a chat with him for about 30 minutes! He is so down to earth. Rob asked that we keep [the pictures] off the [internet] for a few weeks to help against the [paparazzi] sorry. He asked me not too post them."
Trance seems like such a nice fan! That is, until R-Patz, 26, fans went ballistic and accused him of lying. Putting his integrity before his respect for Rob, Trance ended up posting the photo and revealed where Rob is currently filming — in Adelaide, Australia.
"Okay, I'll post one [photo] with him and my sister just to prove it to you guys. OK, the Rob thing is getting a little out of hand. Please calm down, people. He is filming his new film The Rover in the town I live in, in Australia. The other night, me, my mum and sister were walking home from the pub and ran into him out the front, eating and having A beer. We stopped and chatted and got two pictures with him. He asked us to try and keep them off of [Facebook] to not cause issues with the [Paparazzi]. So I've posted a picture to prove it and that's it haha, they are filming for three nights in the main street."
This is why we love Rob. He took the photo even though there was a chance the fan would post it on Facebook, Twitter and other social media outlets — which he did. Rob is such a lover of his fans.
Heck, at least Kristen Stewart, 22, will know where to find him!
What do YOU think, HollywoodLifers? Was it wrong for this fan to post the photo?
— Chris Rogers
More Robert Pattinson News:
- Robert Pattinson Hangs Out With Cute Blonde Fans In Australia — New Pic
- Robert Pattinson With Fans In Australia — Over Kristen Stewart?
- Kristen Stewart & Robert Pattinson Sign Autographs For Fans At 'Breaking Dawn' Premiere
View Comment
These two women(I refuse to call them reporters they need to get a real job) should be ashamed to make their living telling such ridiculous lies. Most of the people on these websites are nothing but parasites they prey on people who are trying to have a career in a very high profile profession. Only an idiot would believe anything they say. They criticize Rob for being in Australia and away from Kristin which proves their stupidity. How is he going to make a movie in Australia without being in Australia. I encourage everyone myself included to boycott these stupid sights that pretend to have legitimate stories when all they have are fabrications and information that violates these people's privacy. I like Rob and I like reading legitimate news about him but these people are ridiculous. If Rob asked that pictures not be made public a true fan would respect his wishes. The relationship between these two people is non of our business and stories like this probably make things even worse.
Posted at 9:09 PM on February 14, 2013
If you promise the man not to post the photos for several weeks, keep your promise! He was nice enough to let you take his photo and chat with you. Keep your word, you fan boy. You will ruin it for everybody. You will have plenty of time later to post all your little pictures. I am sure Robert wouldn't mind you posting the photos in a couple of months.
Posted at 2:40 AM on February 15, 2013
Posted at 8:57 PM on February 14, 2013
Samuelle 40
Posted at 8:30 PM on February 14, 2013
Already knew he was filming in Adelaide that's where other photo was taken prior to this walking down street .Regards Valentines gift how do you know Rob hasn't sorted anything out for her or have you been sitting at her post box or watching for deliveries to her house for hours,I'm sure is all taken care of and neither of them need reminding.For goodness sake leave them lone.
Posted at 8:21 PM on February 14, 2013
For god sakes get over it people. Everytime I read an article there always has to be the "Rupert: BS" thing thrown in to get more headline! Its history..get over it! She errored ..shes not the first to make a kistake…move on for god sakes! This is gettign ridiculous. You act like no other actor or anyone for that matter has ever done this. She learned from her mistake now lets move past it.
Posted at 5:07 PM on February 14, 2013
Sienna. even though Curtis`s report is exceptional, last monday I bought Fiat Multipla from earning $7089 this month and would you believe, ten-k this past-month. without a doubt it is the coolest job I have ever done. I actually started five months/ago and pretty much immediately started to make over $69, p/h. I follow this website,, Ask25.com
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Posted at 5:05 PM on February 14, 2013
HE DIDN'T GIVE AWAY ANYTHING!!!! please, stop making such a drama out of nothing, he is a nice guy that did what every guy of his age would do. he posted one pic saying it's somewhere in Adelaide. don't we know by now it's somewhere in the area? and he has done it only because of some immature girls that mocked him and encouraged to betray Rob's trust. YET he didn't say anything particular about the location just wanted to show off a bit which is fine by me. Rob is a smart guy, don't doubt his judgment ability, he probably knew there wasn't much to reveal. some people will jump on every opportunity to start a war…just saying.
Posted at 3:50 PM on February 14, 2013
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Nobody Special
Posted at 9:18 PM on February 14, 2013
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Posted at 11:22 AM on February 14, 2013
Nobody Special
Posted at 9:20 PM on February 14, 2013


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"I was compelled to do several terrible things," the mother was quoted by police in admitting to the allegations.
She was fined 500,000 yen for violating an ordinance regarding the healthy development of youths.
Jiji Press does not mention Takahashi specifically, but Shukan Bunshun (Feb. 16) provides confirmation in a two-page report.
According to the suspect, encounters took place in November of last year with her son's 15-year-old classmate at a residence in Hachioji City.
Takahashi, 20, is the leader of Team A of the all-girl singing troupe. Singles by AKB48 last year claimed the top five positions for CD sales as compiled by entertainment ranking company Oricon.


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ASHLAND, Ore. – The scene is like that of a disaster movie. Every detail of an earthquake scenario has been recreated, down to the gruesome injuries and panicked victims, as volunteers scramble from one cry of help to another.
The training is a test of problem solving skills and resolve for the newest class of Community Emergency Response Team (CERT) volunteers.
"We're going to rely very heavily on these folks, not only for the skills that they've been taught but to teach other people in the community just-in-time training," said CERT Program Director Terri Eubanks.
CERT volunteers have been deployed 33 times in real-life disasters in the past 15 years. Trainers say those skills in triaging and transporting victims, emergency medical care, and emotional calm can and have saved people from the most common killers.
"Airway obstruction, bleeding, and shock," said Eubanks. "If we can mitigate those from the folks who are injured within the first hour, the likelihood of their survival is increased at least 50%."
The idea is that after today those volunteers will go home and create a network of trained responders on the ground in every community.
"Myself, my household, my neighborhood, and the community," said Volunteer Chelsea Davis. "I want to help any way I can."
Today's training is one of two annual training events for the CERT team. While these volunteers are ready for the field, the next class will begin simulations in the fall.


text:
Widespread neuronal damage and cognitive dysfunction in spinocerebellar ataxia type 3
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Previous studies demonstrated cognitive impairments in spinocerebellar ataxia type 3 (SCA3/MJD); however, there is no consensus about the cognitive domains affected and the correlation with structural brain abnormalities. We investigated the neuropsychological profile and 3T-MRI findings, including high-resolution T1-images, diffusion tensor imaging and magnetic resonance spectroscopy of 32 patients with SCA3/MJD and 32 age-, gender- and educational level–matched healthy controls. We reviewed patients' clinical history and CAG repeat length, and performed assessment and rating of ataxia (SARA)-Brazilian version and the neuropsychiatric inventory. Patients presented worse performance in episodic and working memory and Beck inventories (depression and anxiety). SCA3/MJD patients had a reduction of gray matter volume (GM) in the cerebellum, putamen, cingulum, precentral and parietal lobe. A positive correlation was identified between the cognitive findings and GM of temporal, frontal, parietal, culmen and insula. We observed positive correlation between the brainstem′s fractional anisotropy and digit span-forward. The following cerebellar metabolite groups (measured relative to creatine) were reduced in patients: N-acetyl-aspartate (NAA), NAA + N-acetyl-aspartate-glutamate and glutamate + glutamine (Glx). We found a positive correlation between Corsi's block-tapping task forward with Glx; semantic verbal fluency with phosphorylcholine and glycerophosphorylcholine; digits span-forward with NAA. The cognitive impairments in SCA3/MJD are associated not only with cerebellar and brainstem abnormalities, but also with neuroimaging evidence of diffuse neuronal and axonal dysfunction, particularly in temporal, frontal, parietal and insular areas.
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- Kawaguchi Y, Okamoto T, Taniwaki M, Aizawa M, Inoue M, Katayama S et al (1994) CAG expansions in a novel gene for Machado–Joseph disease at chromosome 14q32.1. Nat Genet 8:221–228 CrossRef
- Schmahmann JD, Sherman JC (1998) The cerebellar cognitive affective syndrome. Brain 121:561–579 CrossRef
- Rub U, Brunt ER, Deller T (2008) New insights into the pathoanatomy of spinocerebellar ataxia type 3/Machado–Joseph disease. Curr Opin Neurol 21:111–116 CrossRef
- Tokumaru AM, Kamakura K, Maki T, Murayama S, Sakata I, Kaji T et al (2003) Magnetic resonance imaging findings of Machado–Joseph disease: histopathologic correlation. J Comput Assist Tomogr 27:241–248 CrossRef
- Murata Y, Yamaguchi S, Kawakami H, Imon Y, Maruyama H, Sakai T et al (1998) Characteristic magnetic resonance imaging findings in Machado–Joseph disease. Arch Neurol 55:33–37 CrossRef
- D'Abreu A, Franca MC Jr, Yasuda CL, Campos BA, Lopes-Cendes I, Cendes F (2012) Neocortical atrophy in Machado–Joseph disease: a longitudinal neuroimaging study. J Neuroimaging 22:285–291 CrossRef
- D'Abreu A, Franca M Jr, Appenzeller S, Lopes-Cendes I, Cendes F (2009) Axonal dysfunction in the deep white matter in Machado–Joseph disease. J Neuroimaging 19:9–12 CrossRef
- Radvany J, Camargo CH, Costa ZM, Fonseca NC, Nascimento ED (1993) Machado–Joseph disease of Azorean ancestry in Brazil: the Catarina kindred. Neurological, neuroimaging, psychiatric and neuropsychological findings in the largest known family, the "Catarina" kindred. Arq Neuropsiquiatr 51:21–30 CrossRef
- Maruff P, Tyler P, Burt T, Currie B, Burns C, Currie J (1996) Cognitive deficits in Machado–Joseph disease. Ann Neurol 40:421–427 CrossRef
- Zawacki TM, Grace J, Friedman JH, Sudarsky L (2002) Executive and emotional dysfunction in Machado–Joseph disease. Mov Disord 17:1004–1010 CrossRef
- Burk K, Globas C, Bosch S, Klockgether T, Zuhlke C, Daum I et al (2003) Cognitive deficits in spinocerebellar ataxia type 1, 2, and 3. J Neurol 250:207–211 CrossRef
- Kawai Y, Takeda A, Abe Y, Washimi Y, Tanaka F, Sobue G (2004) Cognitive impairments in Machado–Joseph disease. Arch Neurol 61:1757–1760 CrossRef
- Garrard P, Martin NH, Giunti P, Cipolotti L (2008) Cognitive and social cognitive functioning in spinocerebellar ataxia: a preliminary characterization. J Neurol 255:398–405 CrossRef
- Klinke I, Minnerop M, Schmitz-Hubsch T, Hendriks M, Klockgether T, Wullner U et al (2010) Neuropsychological features of patients with spinocerebellar ataxia (SCA) types 1, 2, 3, and 6. Cerebellum 9:433–442 CrossRef
- Braga-Neto P, Dutra LA, Pedroso JL, Felicio AC, Alessi H, Santos-Galduroz RF et al (2012) Cognitive deficits in Machado–Joseph disease correlate with hypoperfusion of visual system areas. Cerebellum 11:1037–1044 CrossRef
- Braga-Neto P, Pedroso JL, Alessi H, Dutra LA, Felicio AC, Minett T et al (2012) Cerebellar cognitive affective syndrome in Machado Joseph disease: core clinical features. Cerebellum 11:549–556 CrossRef
- Braga-Neto P, Godeiro-Junior C, Dutra LA, Pedroso JL, Barsottini OG (2010) Translation and validation into Brazilian version of the Scale of the Assessment and Rating of Ataxia (SARA). Arq Neuropsiquiatr 68:228–230 CrossRef
- Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 44:2308–2314 CrossRef
- Malloy-Diniz LF, Lasmar VA, Gazinelli Lde S, Fuentes D, Salgado JV (2007) The Rey auditory-verbal learning test: applicability for the Brazilian elderly population. Rev Bras Psiquiatr 29:324–329 CrossRef
- Raven JC (2003) Teste das Matrizes Progressivas—Escala Geral (Séries A, B, C, D e E). CEPA, Rio de Janeiro
- Lezak MD (1995) Neuropsychological assessment. Oxford University Press, Oxford
- Nascimento E (2004) Escala de Inteligência Wechsler para adultos: Adaptação e padronização de uma amostra brasileira. Casa do Psicólogo, São Paulo
- Wechsler D (1987) Wechsler memory scale—revised. The Psychological Corporation, San Antonio
- Santos FH, Bueno OF (2003) Validation of the Brazilian children's test of pseudoword repetition in Portuguese speakers aged 4 to 10 years. Braz J Med Biol Res 36:1533–1547
- Kaplan EF, Weintraub S (1983) The Boston naming test. Lea & Febiger, Philadelphia
- Hooper HE (1983) Hooper visual organization test (VOT). Western Psychological Services, Los Angeles
- Cunha JA (2005) Teste Wisconsin de classificação de cartas. Casa do Psicólogo, São Paulo
- Beck AT (1993) Beck depression inventory manual. Psychology Corporation, San Antonio
- Provencher SW (2000) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30:672–679 CrossRef
- Govindaraju V, Young K, Maudsley AA (2000) Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 13:129–153 CrossRef
- Cavassila S, Deval S, Huegen C, Van Ormondt D, Graveron-Demilly D (2001) Cramer-Rao bounds: an evaluation tool for quantitation. NMR Biomed 14:278–283 CrossRef
- Subramony SH, Hernandez D, Adam A, Smith-Jefferson S, Hussey J, Guinm-Hardy K (2002) Ethnic differences in the expression of neurodegenerative disease: Machado–Joseph disease in Africans and Caucasians. Mov Disord 17:1068–1071 CrossRef
- Coutinho P (1994) História da doença de Machado-Joseph. Doença de Machado-Joseph: estudo clínico, patológico e epidemiológico de uma doença neurológica de origem portuguesa. Bial, Porto: Bial
- Sudarsky L, Coutinho P (1995) Machado–Joseph disease. Clin Neurosci 3:17–22
- Stoodley CJ, Schmahmann JD (2010) Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46:831–844 CrossRef
- Kravitz DJ, Saleem KS, Baker CI, Mishkin M (2011) A new neural framework for visuospatial processing. Nat Rev Neurosci 12:217–230 CrossRef
- Schmahmann JD (2004) Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci 16:367–378 CrossRef
- Birn RM, Kenworthy L, Case L, Caravella R, Jones TB, Bandettini PA et al (2010) Neural systems supporting lexical search guided by letter and semantic category cues: a self-paced overt response fMRI study of verbal fluency. Neuroimage 49:1099–2107 CrossRef
- Taniwaki T, Sakai T, Kobayashi T, Kuwabara Y, Otsuka M, Ichiya Y et al (1997) Positron emission tomography (PET) in Machado–Joseph disease. J Neurol Sci 145:63–67 CrossRef
- Oz G, Hutter D, Tkac I, Clark HB, Gross MD, Jiang H et al (2010) Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord 25:1253–1261 CrossRef
- Ernst T, Jiang CS, Nakama H, Buchthal S, Chang L (2010) Lower brain glutamate is associated with cognitive deficits in HIV patients: a new mechanism for HIV-associated neurocognitive disorder. J Magn Reson Imaging 32:1045–1053 CrossRef
- Kantarci K, Lowe V, Przybelski SA, Senjem ML, Weigand SD, Ivnik RJ et al (2011) Magnetic resonance spectroscopy, beta-amyloid load, and cognition in a population-based sample of cognitively normal older adults. Neurology 77:951–958 CrossRef
- Title
- Widespread neuronal damage and cognitive dysfunction in spinocerebellar ataxia type 3
- Journal
Journal of Neurology
Volume 260, Issue 9 , pp 2370-2379
- Cover Date
- 2013-09-01
- 10.1007/s00415-013-6998-8
- Print ISSN
- 0340-5354
- Online ISSN
- 1432-1459
- Publisher
- Springer Berlin Heidelberg
- Additional Links
- Topics
- Keywords
- Spinocerebellar ataxia type 3
- Cognitive deficits
- Voxel-based morphometry
- Diffusion tensor imaging
- Magnetic resonance spectroscopy
- Industry Sectors
- Authors
- Tátila Martins Lopes (1)
- Anelyssa D′Abreu (1)
- Marcondes Cavalcante França Junior (1)
- Clarissa Lin Yasuda (1)
- Luiz Eduardo Betting (1)
- Adriana Bastos Samara (1)
- Gabriela Castellano (3)
- Júlio César Somazz (3)
- Marcio Luiz Figueredo Balthazar (1)
- Iscia Lopes-Cendes (2)
- Fernando Cendes (1) (4)
- Author Affiliations
- 1. Laboratory of Neuroimaging, Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil
- 3. Department of Cosmic Rays and Chronology, Institute of Physics GlebWataghin, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil
- 2. Neuro-genetic Laboratory, Department of Medical Genetics, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil
- 4. Department of Neurology, FCM-UNICAMP, Cidade Universitária, Campinas, São Paulo, 13083-970, Brazil


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Compulab Exeda smartphone dual boots Android and Windows Mobile
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text:
Disposal wells common in Victoria County
Brian Cuaron
Oct. 11, 2011 at 5:11 a.m.
Updated Oct. 12, 2011 at 5:12 a.m.
The difference between a commercial and non-commercial disposal well is that non-commercial wells only take waste produced on the site where oil-and-gas drilling occurs, Ramona Nye said.
There are 330 oil-and-gas leases in the county, said John Haliburton, chief appraiser for the Victoria County Appraisal District.
The purpose of non-commercial disposal wells was so that oil-and-gas companies don't have to haul saltwater to a commercial site, said Ken Roehl, who has worked in the industry for 43 years. Utilizing a commercial site is expensive.
Saltwater at times comes up mixed with oil, Roehl explained.
Feb. 14 - Agreement between Fordyce Holdings Inc. and American Disposal takes effect, ending environmental lawsuit.
Feb. 17 - American Disposal takes out disposal well permit. A copy is sent to adjacent landowners.
June 2 - American Disposal receives injection well permit.
Aug. 3 - Commissioner Kevin Janak holds town hall, start of when most find out about the proposed disposal well.
Sept. 8 - Citizens group sends an about 600-signed petition against the disposal well to the railroad commission, state Sen. Glenn Hegar and state Rep. Geanie Morrison.
Sept. 12 - Commissioners court asks railroad commission for public hearings on disposal well and drilling permits.
Sept. 20 - Citizens group presents case to city council.
Sept. 28 - American Disposal cancels permit.
Although a disposal well created a controversy recently in Victoria County, they are common in the area.
There are 67 active disposal wells in the county, including six commercial disposal wells, said Ramona Nye, Texas Railroad Commission spokeswoman. There also are a total of 355 permitted wells in the county.
Disposal wells, also called injection wells, are used to dispose of saltwater brought up to the surface during oil and gas production, according to the commission's website. Disposal-well owners are required to use a three-casing system to prevent contamination of groundwater.
However, despite the number of disposal wells in the county, as well as multiple safety provisions, rural residents and elected officials rose up against a proposed disposal well last month.
American Disposal Services received a disposal well permit June 2 from the Texas Railroad Commission for a site near Farm-to-Market Road 1685 and U.S. Highway 77. The well would have injected the salt water at a depth between 2,700 to 3,100 feet, said J.D. Ivey, company president.
The company requested that its permit be cancelled on Sept. 28, after it said it found a site closer to the Eagle Ford Shale, where many of its customers drill. The railroad commission approved the request.
Opponents, such as Precinct 2 Commissioner Kevin Janak, said the site was too close to the Guadalupe River.
That was the same position for Ken Roehl, spokesman for the Victoria Residents for a Clean Water Community group that protested the well. He also thought the site was too close to nearby residents, who depend on private water wells to the Chicot and Evangeline aquifers.
The railroad commission doesn't require a certain distance between a water well and disposal wells, wrote Nye in an email. This was because disposal-well construction requirements already seek to protect usable quality groundwater.
Opponents said the lay of the land sloped to the river, Victoria's primary water source, endangering it should a spill occur at the site. Chemicals found in saltwater separated from oil can eat through the steel casing of a disposal well, Roehl explained.
Roehl also noted that American Disposal planned to move from its current Victoria County location after an environmental lawsuit alleged the company placed toxic materials on the surface. Janak said the proposed site had a history of flooding.
For his part, Ivey said that disposal wells near water sources were common in Texas. He said the planned safety provisions made the well "steel-door secure."


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Fox News | September 6, 2010
WASHINGTON – Three-year-old Hannah really misses her daddy. He has been in Iraq for almost a year.
"She's a real trooper," said her mother Shellie Jensen. "She knows her daddy is doing something real important. But it's been a challenge."
Hannah talks to her dad – on pretend and real phones – but her mom was looking for something else to fill the void. When she heard that volunteers with Operation Kid Comfort make quilts for military children with their parent's photos on it, that sounded perfect to her.
"I thought a blanket would be a way … of Daddy hugging you. And knowing she's been with him before and he'll be back again, I think is what comforts her," said Jensen.
Cathy Jung knows how comforting these quilts can be. She got one for her son Nathan when his dad was in Afghanistan.
"When [Nathan] needed that extra piece of security, he had something to hold on to while daddy was away," Jung said.


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What does FOR mean in Transportation?
This page is about the meanings of the acronym/abbreviation/shorthand FOR in the Governmental field in general and in the Transportation terminology in particular.
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- for(Conjunction)
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New York Times calls Ray Chenez "luxury casting"
"In a touch of luxury casting, countertenor Ray Chenez sang radiantly."
- Corinna da Fonseca-Wollheim, New York Times
Click here for the full review of the Orchestra of the League of Composers concert on June 16, 2014
Rave Reviews for Ray's Canadian Debut as Cherubino with Pacific Opera Victoria
"What Chenez does in a mezzo's register is technically amazing and often affecting. His Cherubino is at once hilarious and sympathetic (Thursday's audience plainly adored him)."
- Kevin Bazzana, Times Colonist
"The opera's casting was pitch perfect for Ray Chenez's Cherubino, whose stunning countertenor and lanky gesticulations easily passed for the lusty teenager he's written as. Typically a role for a mezzo-soprano in drag, the choice to cast a man as Cherubino in this production played brilliantly into some of the best physical humour of the piece."
- Melanie Tromp Hoover, CVV Magazine
"Countertenor Ray Chenez captured the audience's heart."
- Monica Prendergast, CBC Radio
2014 George London Award Winner
Ray was awarded the top prize of $10,000 from the George London Foundation Awards Competition - one of the oldest and most prestigious vocal competitions in North America.
Past winners include Christine Brewer, Joyce DiDonato, Renée Fleming, Catherine Malfitano, James Morris, Matthew Polenzani, Sondra Radvanovsky, Neil Shicoff, and Dawn Upshaw.


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WoW | 4 Comments |
Recent Comments:
Warlocks may cast green fire spells in MoP {WoW}
Mar 25th 2012 3:51PM I'm just going to leave this right here... http://www.wowhead.com/npc=3183#abilities
Sure, warlocks don't use fireball, but they use immolate, and this one is green. Go find the NPC in game and have him cast it on you; it's only a short walk to his cave from the orc starting area if you want proof.
The model is already there, just give it to us... please. This also brings up the point that, if it's easy enough to make spell graphics like this for random NPC's... why wouldn't they be able to easily hand them over to warlocks? I don't really understand the logic there. Is the level 5 orc NPC really so special to where he deserved green fire, but the player class isn't good enough for it or something?
I'll be the first to admit, I don't know how technical and complex a change like this could be the implement, but come on... From what I'm reading in this thread about there being green incinerate graphics in-game already and other such things, is it really too much to ask that we be given a way to wield them?
Blood Pact: A tale full of cheering and demonic fury {WoW}
Mar 21st 2012 5:37PM Ah, whoops. I accidentally posted my reply as a new comment.
Blood Pact: A tale full of cheering and demonic fury {WoW}
Mar 21st 2012 5:32PM @Daedalus - I understand your point about how warlocks don't really 'help' people. Truly, that has crossed my mind several times in the past whenever I consider the 'drain healer' idea that I mentioned. However, in practice, all a warlock tanking spec would be doing is helping people by taking blows for them, when in my mind, they should be turning their nose up at the prospect. They have demons to take blows for them when their bull-headed, less intelligible, bulkier group-mates aren't around. The reason that I can see the healing warlock idea working is because... well, I -can't- see warlocks wanting to take a blow to the jaw. No, they would much rather sit back and laugh at someone who's doing the tanking for them, choosing to heal the dumb sap and let them do all of the work.
Basically, I imagine it to work similarly to the idea of using Health Funnel on the Voidwalker. Let them take the hits because they're too stupid to say no, and I'll be back here watching. Again though, this isn't to say that I'm right; your point is entirely valid. That's just how I more so imagine the class's flavor to work. Less of a front-lines bad ass, more of a behind-the-scenes puller of strings mastermind. Either way, I'm certainly not campaigning for the idea. I'm much happier having the warlock as a pure DPS class.
@Derrek - There's no disputing that, before Cataclysm, one could indeed tank in Metamorphosis form for a short while. ...Well, okay, maybe it would be a bit tricky to maintain aggro if your tank was really, really good at their job, but that's irrelevant. I do see your point about the fact that we used to pull a lot of aggro, and sometimes we still can. It would be fairly common in Wrath for me to have to pop my Soul Shatter a good fifteen seconds into the fight, just to make sure that the Big Baddie wasn't going to devour my face.
The thing is, I don't understand why the 600% armor is coming back now. I understand your points about flavor, and how turning into a giant demon should come with a bonus to our durability. No, really, I totally get it. But, I don't see that how it will be useful unless we move away from the current model of the game where, as Blizzard says fairly frequently these days, threat is almost a non-issue. I understand where the extra armor could be useful for soloing content and it's obvious PvP applications, but that's about it in my opinion.
Anyway, I'm not really saying that we 'shouldn't' have a tanking spec, so much as I don't really want it myself. I like the warlock class as it is, that being caster DPS with a melee-range spec in the form of Demonology. I don't see much appeal to the idea of Metamorphosis tanking, but that's just me. I'll stand back and play the more traditional caster specs, personally.
Spiritual Guidance: Brainstorming the future of shadow priest glyphs {WoW}
Mar 21st 2012 4:57PM I'm going to try and stick with the theme of the article, and the overall feeling of the new minor glyphs. In other words, more graphical, less technical game-changers like "I want to use Heal in Shadowform."
1.) Glyph of the Blackened Sanctum: While in Shadowform, your Power Word: Shield is formed with the powers of darkness, giving it a new appearance.
2.) Glyph of Silent Murmurs: While using Mind Vision or Mind Control on an enemy player, they will hear the whisperings of madness. (Sends the subjected player generic whispers, similar to those generated by the Puzzle Box of Yogg-Saron.)
3.) Glyph of Slithering Shadow: Your Shadowy Apparitions will now take the form of miniature Shadowfiends.
4.) Glyph of the Shifting Shade: When in Shadowform your Fade spell now causes you to create after-images as you move, replacing it's previous visual effect. (To reduce lag, the after-images would only last a second or two.)
5.) Glyph of Atoned Respite: While in Shadowform, damage caused to yourself via Shadow Word: Death causes emerald fire to momentarily consume your form. (I say green fire because, 'warlocky' or not, can anyone here really say that they dislike how Anathema's green energy looked while they were in Shadowform? I know I loved the contrast against the purple shroud.)
6.) Glyph of Writhing Silence: Silence now causes a tendril of pure shadow energy to coil around it's victim's mouth. ...As well as the rest of their head.
Anyway, just some ideas of mine. I'm rather fond of Heii's 'Glyph of the Skull,' and Phredreeke's 'Dark Resurrection.' I love the idea of glowing eyes for Shadowform too, as well as the Shadow Raven idea. All lovely suggestions. Keep up the good work, everyone!


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4th of July Party Supplies
4th of July scene setters can be placed around any room or hall and create the perfect setting. Our 4th of July novelty favors are sure to be a memorable keepsake for your guests. With 4th of July party supplies from Cool Glow, your 4th of July party will be a blast! 4th of July Party Supplies are a must-have when you are planning the best party in town!
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Unicef Open Tickets
Find the Unicef Open tickets you're looking for on viagogo, the world's largest ticket marketplace. Select a match from the Unicef Open fixtures to view the range of tickets available. You can also sell your spare Unicef Open tickets on viagogo, and listing tickets is free. All Unicef Open tickets are covered by the viagogo Ticket guarantee!
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viagogo is your online ticket marketplace for concert tickets, sports tickets and theatre tickets.


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Hair Updos
Updos can be the answer to all types of hair 'mares. Whether you have grubby hair, it's raining, or if you just fancy an easy hairstyle change, an updo can be the perfect solution for work, parties or down-time. Whatever the occasion, let our pick of the best celebrity hair updos inspire you.
For simple but effective updo ideas, take notes from Emma Watson, Kate Bosworth and Diane Kruger, who have been giving us a masterclass in high-impact updos which don't require much time or effort.
Don't worry if the idea of styling your own hair, let alone in an intricate-looking updo, gets you in a flap. We've found styles that will work for you.
Get inspiration from our celebrity looks and get practising in front of the mirror, or show your favourites to your hair stylist. Either way, you're about to have a very chic updo....


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Go to Admin » Appearance » Widgets » and move Gabfire Widget: Social into that MastheadOverlay zone
Congratulations to Justin Chenette, one of the newest members of Maine's State House. And, at the age of 21, he's also the nation's youngest openly gay lawmaker.
NECN provides more information:
"I think it's important that young people have a seat at the table and
that's what I am trying to accomplish here," says Chenette, who won the
November election by a huge margin.
Surprisingly, Chenette went
into the campaign with strong name recognition. As a high school
student, he hosted a political show on public access television and if a
candidate wanted to get elected in Saco, they found their way to his
There were skeptics [when he announced his candidacy], but Chenette wasn't deterred. "If
you believe in something you have to go for it, you can't let other
people tell you know when you believe yes, that has been a theme in
anything I have taken on."
Chenette took a leave of absence from his position as an assistant producer at Maine Fox 23's Good Day morning show to run for office. Obviously that decision paid off.
AFTER THE JUMP, NECN's interview with Chenette.
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Enhance ITSM Tool
The AssetStudio® Discovery & Inventory modules can populate a CMDB to enhance any ITSM tool
IT Asset Management (ITAM)
Advanced Inventory that goes the extra mile to give you visibility of all assets on the infrastructure
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Watch the Video below to learn more >


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Silencing of the cryptic mating-type loci HMR and HML requires the recognition of DNA sequence elements called silencers by the Sir1p, one of four proteins dedicated to the assembly of silenced chromatin in Saccharomyces cerevisiae. The Sir1p is thought to recognize silencers indirectly through interactions with proteins that bind the silencer DNA directly, such as the origin recognition complex (ORC). Eight recessive alleles of SIR1 were discovered that encode mutant Sir1 proteins specifically defective in their ability to recognize the HMR-E silencer. The eight missense mutations all map within a 17-amino-acid segment of Sir1p, and this segment was also required for Sir1p's interaction with Orc1p. The mutant Sir1 proteins could function in silencing if tethered to a silencer directly through a heterologous DNA-binding domain. Thus the amino acids identified are required for Sir1 protein's recognition of the HMR-E silencer and interaction with Orc1p, but not for its ability to function in silencing per se. The approach used to find these mutations may be applicable to defining interaction surfaces on proteins involved in other processes that require the assembly of macromolecular complexes.
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Watch The Lyric Video For Timbaland's 'Break Ya Back' Featuring Dev [VIDEO]
Hit producer and rapper Timbaland just keeps banging out great tracks like "Break Ya Back" featuring R&B up-and-comer Dev. The mid-tempo song might be a bit slow for the club, but it has a distinct moodiness to it that will translate well to a late night drive or chill party.
Watch DEV & Enrique Iglesias Get 'Naked' In Las Vegas [VIDEO]
Their lyric video is no exception with it's colorful fusion that is just as mesmerizing as the beat itself.