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In order to further our understanding of the biological role of desmin, the muscle-specific intermediate filament protein, a null mutation in the desmin gene was introduced into the germ line of mice. Despite the complete lack of desmin, these mice developed and reproduced. Since we show that skeletal, cardiac, and smooth muscles form in the Des-/- mice, it is reasonable to propose that desmin is not essential for myogenic commitment or for myoblast fusion or differentiation in vivo. However, morphological abnormalities were observed in the diaphragm of adult mice; these were demonstrated by disorganized, distended, and nonaligned fibers. The heart presented areas of hemorrhaging in which fibrosis and ischemia were observed. We have also shown that the absence of desmin produces specific defects in smooth muscles. In conclusion, our results have demonstrated that desmin is not required for the differentiation of skeletal, cardiac, and smooth muscles but is essential to strengthen and maintain the integrity of these tissues.
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text: | A week of ups and downsJanuary 30, 2013 - Pam RodgersSunday's ice storm wasn't as brutal as the one in 2007 but it was enough to make me nervous on the road ways. My brother was nice enough to let me crash at his place after work so I didn't have to brave the county road to Garwin. My week took a 360 degree turn when I got a call Monday that my car was done at the Ford garage. I immediately made plans to pick it up that day. They did a great job on the car. It looks perfect. I'm so glad to get it back after 20 days. Now on Wednesday, Mother Nature has reared its ugly head and reminded us that it is winter. I was just fine without snow, but I suppose we need it on some level. I can't wait for Spring to get here but with the weather we've been having, who knows what that will bring. I will just have to wait and see what the rest of the week brings. Saturday is my birthday so I can only hope that it ends on a high note. | |

subset: commoncrawl


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So you know what? A great time in the past has returned to consider my cum in her own mouth. Feast your vision on 21 years old cumslut Som from Koh Samui. When i first met this horny little Thai teen when she only agreed to be 18 and that i did a creampie scene together with her at Creampie Thais. Now, 3 years later, my small little Asian Fuck Toy has returned for an additional load…this time throughout her face! Are you able to fucking accept is as true? Her looks continue to be stunning and she or he isn't shy any longer. She's honed her drawing and fucking abilities, that have been very good to start with, but this time around around I recieve to blast my cum into her hot mouth watching her drool it over her amazing large lips and all sorts of over her body. Will Som return for an additional facial cumshot? Rely on it! Join how to see Som creampied at Creampie Thais and facialized at Asian Suck Dolls! p.s. I do not understand what that tattoo above her cunt is but It might say "I love fucking whitened males!"
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In order to get started, you'll need to understand the five essential building blocks of every Joomla template. In the five tutorials below we guide you through them all:
- Part 1: Template setup and templateDetails.xml
- Part 2: Index.php
- Part 3: CSS / Cascading Style Sheets
- Part 4: Images
- Part 5: Security
These tutorials are part of our full Joomla Template Class available to all members. Click here to find out more.
Part 1: Template Setup and templateDetails.xml
Part 1: Session Notes
Copy and Paste:
Part 2: index.php
Part 2: Session Notes
Copy and Paste:
Part 3: CSS - Cascading Style Sheets
Part 3: Session Notes
Part 3: CSS Tutorial Links
Part 4: Images
Part 4: Session Notes
(Right Click - Save As - then save to your images directory for your template)
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We need to make sure that your template is secure and not easily hacked.
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Poor Floyd Mayweather Denied Early Parole By Clearly Racist Judge
Findlaw – A Las Vegas judge denied Floyd Mayweather's request to be let out of jail early. Mayweather had asked for an early release as he said his health was suffering from prison food and lack of bottled water. Ten days into his sentence, Mayweather petitioned to be released from jail. Mayweather's complaints ranged from low-quality food to his dislike of tap water (he apparently only wanted to drink bottled water), reports the AP. As a result, the undefeated fighter said that his health suffered and that his prison stint could jeopardize his career as a fighter. The Judge, Melissa Saragosa, denied Mayweather's request saying that the fighter receives adequate food and water in prison. He just needs to eat and drink what all the other prisoners are eating and drinking.
Shit ain't right. Shit ain't right. Where is Jesse Jackson and Al Sharpton when you fucking need him? This is some racist ass shit. I mean brother needs some fucking bottled water ASAP! Enough of this tap shit! And build him a god damn ring to spar in and cook him some food. Stop treating his ass like a god damn prisoner. He's Floyd fucking Mayweather. If he doesn't get out of this place soon he may get out of shape. Maybe never box again. Did you hear me? He may never box again! If that happens that's on you judge! That's on you! I hope you can sleep at night with that blood on your hands. It's not his fault he beat his ex girlfriend and got arrested. Oh wait a minute. Yes it is. Nevermind then. Carry on.


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Last Modified: May 2, 2010
Dear OncoLink "Ask The Experts,"
I've just been diagnosed with cancer. Will I be able to keep my job?
Rodney N. Warner, Staff Attorney at The Legal Clinic for the Disabled, Staff Attorney at The Legal Clinic for the Disabled, responds:
You are covered under the Americans with Disabilities Act, if there are 15 or more employees. You may be covered by similar state law, which often covers smaller employers. If you can perform the essential function of the job, with or without reasonable accommodation, your employer needs to reasonably accommodate you, unless that accommodation would present an undue hardship on the employer. It's a case by case issue, depending on the facts of what you can and cannot do, the nature of the job, and the impact on the employer.
A great resource for work related issues is Cancer and Careers.
This question and answer was part of the OncoLink Brown Bag Chat Series, Legal & Financial Challenges Facing People with Cancer. View the entire transcript here.
Feb 7, 2011 - More than 300,000 U.S. cancer cases could be prevented annually with changes in diet, physical activity, and alcohol intake, according to a report released Feb. 4 by the World Cancer Research Fund. In addition, another report published online Feb. 4 in CA: A Cancer Journal for Clinicians notes that cancers associated with lifestyles and behaviors related to economic development will keep increasing in developing nations if preventive measures are not widely adopted.


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Rocky Mountain National Park bouncing back after floods and federal shutdown
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Randy Lee Bumgarner
I have over 25 years of experience handling divorce, family law, criminal defense law and DUI cases. These range from complex divorce and family law matters involving difficult child custody disputes to high-value assets and property distribution agreements. I am also experienced in criminal defense cases from serious felony cases to simple misdemeanor charges or DUI.
I was born and raised in a little farm town of about 200 people. When I left to go to law school my parents said make us proud. I have spent my career proving that their confidence in me was well founded. That is why when you hire Randy Lee Bumgarner, you get Randy Lee Bumgarner and not a legal assistant or intern. I believe that every one of my clients is the most important client in my office and that each deserves my full attention.
As a parent, I can feel the frustrations of a mother or father involved in custody dispute. I know the disappointment and heartache that comes with divorce. For this reason, I try to make every lawsuit as painless as possible.
So, if you want and insist upon real and personal attention choose me, Randy Lee Bumgarner, as your legal representative.
Call Randy today to schedule a free consultation with an experienced family law, criminal defense, and personal injury lawyer. Randy Lee Bumgarner offers fully confidential free consultations. Evening and weekend appointments are available, and he has two convenient locations to serve you.
Areas of Practice
- Personal Injury
- Family Law
- Bankruptcy Law
- Criminal Law
- Child Support
- Custody & Visitation
- Divorce
- Workers' Compensation Law
- Felony & Misdemeanor
- Auto Accidents
- Department of Human Services
- Military Law
- Motor Vehicle Accidents -- Plaintiff
- Foreclosure
Bar Admissions
- Oklahoma, 1984
- U.S. District Court Western District of Oklahoma, 1984
- U.S. Court of Appeals 10th Circuit, 1986
- Oklahoma City University School of Law, Oklahoma City, Oklahoma
- Illinois College, Jacksonville, Illinois
- Honors: Student Senate, President Gamma NU Literary Society
- Major: History
- Major: Political Science
- Major: Business Admin & Economics
- Business Law, Oklahoma State University, 2002
- Spanish
- Gamma Nu


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Heart Health
To Be Or Not To Be… On Statins?
Newly released guidelines for the use of cholesterol-lowering statin drugs recently erupted into an unusual headline-grabbing dispute among heart care experts, leaving patients in a state of bewilderment.
The Troubled Heart: How Depression and Anxiety Impact Heart Disease
Everyone feels sad or anxious occasionally. But for some, depression and/or anxiety can be more extreme, affecting both psychological and physical health.
Looks Matter: The Signs Of Aging That Can Signal Heart Disease
As if getting older is not challenging enough, research points to certain signs of aging as a marker for higher risk of heart disease.
Top Five Foods For Prevention Of Heart Disease
Heart disease is the leading cause of death among both men and women in the United States, but there are things you can do to prevent it from developing in the first place.
E-Cigarettes And Heart Health: An Aid To Quitting Or A Smoldering Risk?
Electronic cigarettes, or e-cigarettes, are a hot item these days. Here are the drawbacks, possible benefits, and the final analysis.
How The Flu Affects The Heart
Getting the flu often just means a few days of feeling lousy, but for some, it can have dangerous effects on the heart.
How Energy Drinks Could Hurt The Heart
The hectic pace of modern life can make it seem hard to keep up. Some may try turning to energy drinks, which are purported to provide mental and physical stimulation, to help stay revved and alert. But are they safe?
VIDEO: Tour An Operating Room At The CardioVascular Institute
Tour one of the state-of-the-art operating rooms at the CardioVascular Institute.
VIDEO: Five Steps To Heart Health
Five simple tips to know, eat, and do to maintain a healthy heart.
VIDEO: Life Saving Surgery At CardioVascular Institute
Meet George — a patient who's life was saved by surgeons at the CardioVascular Institute.


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On Thin Ice:Expedition to a Crumbling Ice Shelf
Scientists blog from Antarctica and provide a glimpse of what it's like to do research in the field. Read their blog ...
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What's hot in the news around climate and sea ice and what are scientists talking about now? Read more...
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When scientists talk about the cryosphere, they mean the places on Earth where water is in its solid form, frozen into ice or snow. Read more ...
On Friday, 06 February 2015 from 8:00 a.m. to 5:00 p.m. (USA Mountain Time), we will be performing scheduled maintenance, which may cause temporary disruptions to our Web site, applications, and FTP. We apologize for any inconvenience this may cause you.
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This data set contains radar echograms taken over Greenland and Antarctica using the Center for Remote Sensing of Ice Sheets (CReSIS) Accumulation Radar instrument. The data were collected as part of Operation IceBridge funded campaigns.
Dataset Creator: Leuschen, C. Dataset Title: IceBridge Accumulation Radar L1B Geolocated Radar Echo Strength ProfilesDataset Release Date: 2014-06-30updated 2015Dataset Release Place: Boulder, Colorado USADataset Publisher: NASA NSIDC DAAC: NASA National Snow and Ice Data Center Distributed Active Archive CenterVersion: 2Online Resource: http://nsidc.org/data/iracc1b.html
Start Date: 2013-03-21
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Data Center Personnel Name: NSIDC User ServicesPhone: 1 303 492-6199 Fax: 1 303 492-2468 Email: firstname.lastname@example.com Address: National Snow and Ice Data Center CIRES, 449 UCB University of Colorado City: BoulderProvince or State: COPostal Code: 80309-0449Country: USA
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City: BoulderProvince or State: COPostal Code: 80309-0449Country: USA
NASA DAAC at the National Snow and Ice Data CenterData Center URL: http://nsidc.org/daac/index.html
Distribution Media: FTPDistribution Size: 115 GBDistribution Format: NetCDF
Distribution Media: FTPDistribution Size: 39 MBDistribution Format: XML
Distribution Media: FTPDistribution Size: 2 GBDistribution Format: Joint Photographic Expert Group (JPEG) (.jpg)
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VIEW PROJECT HOME PAGECReSIS Web site
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VIEW RELATED INFORMATIONVersion 01 binary IceBridge Accumulation Radar L1B Geolocated Radar Echo Strength Profiles
Lewis, C. 2010. Airborne UHF Radar for Fine Resolution Mapping of Near Surface Accumulation Layers in Greenland and West Antarctica, Department of Electrical Engineering and Computer Science: Master's Thesis, University of Kansas.Lewis, C., A. Patel, H. Owen, F. Rodriguez-Morales, C. Leuschen, S. A. Seguin, J. Ledford, K. Player, and S. Gogineni. 2009. A Radar Suite for Ice Sheet Accumulation Measurements and Near-Surface Internal Layer Mapping, Geoscience and Remote Sensing Symposium, IEEE International, IGARSS 2009, pp.V-441 - V-444, doi: 10.1109/IGARSS.2009.5417635.Rodriguez-Morales, F., P. Gogineni, C. Leuschen, C. T. Allen, C. Lewis, A. Patel, L. Shi, W. Blake, B. Panzer, K. Byers, R. Crowe, L. Smith, and C. Gifford. 2010. Development of a Multi-Frequency Airborne Radar Instrumentation Package for Ice Sheet Mapping and Imaging, Proc. 2010 IEEE Int. Microwave Symp., Anaheim, CA, May 2010, 157-160.
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After Turlockers voted to approve Measure A on the November ballot with a nearly 74 percent vote, city council candidates will now be charged with running in their home districts in future elections rather than the current at-large election system that lets the top two candidates take the seats.
Although area farmers are hoping for an El Niño to wash away California's drought, weather forecasts are indicating yet another dry year.
In a sign of recovering economic times, the City of Turlock will be hiring an Administrative Services Director, a position that has not been filled since 2009.
There are approximately 100 boards and commissions to which the Stanislaus County Board of Supervisors appoints community members and with several current vacancies for various unspecified boards as well as those unique to District 2 residents, locals interested in serving their community now have ample opportunity to do so.
The growing prescription drop-off program that allows individuals to dispose of unused medications in a safe manner will soon have a site in Turlock.
The 3.4 million small businesses in California that employ more than half the state's workforce could be facing a health insurance tax per the Patient Protection and Affordable Care Act. On Tuesday Congressman Jeff Denham left Washington to make a local appearance and address small business owners' concerns regarding the tax at the Modesto Chamber of Commerce, an event hosted by the Stop the HIT coalition.
City of Turlock Planning Commissioners will consider amending the East Tuolumne Master Plan on Thursday which would increase the number of units built on what is currently farm land near the city's eastern border.
It took a bending of the rules, but the Mayor's Economic Taskforce finally approved the final draft of its Economic Development Strategic Plan at a second meeting Tuesday that was called after a meeting was cancelled last week due to lack of quorum.
The Turlock City Council voted unanimously to accept and fund a portion of a federal grant that will result in the Turlock Police Department hiring four new officers.
The Turlock City Council will decide on Tuesday if the Turlock Police Department will receive four new officers and six new vehicles in separate items on their agenda.
Fire stations need certain equipment like hoses, ladders, and engines to do their jobs successfully, and in these times that also includes internet access.
Residents fuming over the smoking ban at city parks being discussed by Turlock's Arts, Parks, and Recreation Commission in recent months may be surprised to find out that smoking in parks is already technically illegal.
"Paper or plastic?" This commonly asked question at grocery stores across the country will soon be rendered obsolete as Gov. Jerry Brown signed into law a bill that will prohibit stores from offering single-use plastic bags at check out.
The Turlock Police Department has been awarded a half million dollar grant to hire new officers, but it will be up to the Turlock City Council if it is accepted or not.
It was less than one year ago that Nicole Esparza and her four daughters were living in a cramped one bedroom apartment when a man attempted to break into their home.
In a sign of recovering times the number of complex construction projects is on the rise in Turlock, meaning the City needs more staff to keep its customers satisfied.
Seven churches of different denominations in Denair have one thing in common: they are dissatisfied with the rate they are paying for water.
The intersection of Golden State Boulevard and Berkeley Avenue, as well as the tangential Golf Road, is Stanislaus County property and on Tuesday the Board of Supervisors approved taking the first step towards overhauling the commonly congested intersection.
The Turlock City Council approved two motions Tuesday night that will simultaneously improve the curb appeal of one neighborhood and bolster the funds for a nonprofit agency helping the community's homeless.
Transit services for those in need in the community are becoming much more comprehensive due to the Turlock City Council's approval of an agreement with a new firm to sell advertising on local buses, the revenue of which allows the City to provide transit tickets to local nonprofits and the Turlock Unified School District.
When Mayor Matt Beekman took the microphone Monday evening to deliver his State of the City address at the Hughson City Council meeting, he had one piece of news of which not all mayors can boast: the City's General Fund reserves are at 83 percent.
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Boating Industry's Top 100 Hall of Fame
MarineMax is honored to be a member of Boating Industry's Top 100 Dealers Hall of Fame.
Each year Boating Industry magazine recognizes the top dealers in the country. These dealers understand that delivering on the promise of the boating lifestyle - not just a boat - is the number one key to success. After being awarded the number one dealer spot in 2005 and 2006, MarineMax was retired from contention in future rankings. However, in recognition of the company's ongoing efforts and continued success, Boating Industry honored MarineMax with the first, and at the time, only induction into its Hall of Fame in 2007. Companies are inducted into the Hall of Fame after twice being ranked the number one dealer. MarineMax is now one of only three dealers to be part of this elite group.
"These dealers represent the best of the best in the marine industry," said Boating Industry Editor-in-Chief Jonathan Sweet. "From thousands of dealers across North America, these companies stand out for their financial performance, dedication to customer service and creative marketing."
MarineMax was also proud to receive the Best In Class Award for Best Marketing.
This year, the Top 20 members of the Top 100 were ranked, with the remaining 80 being recognized as Top 100 dealers. For complete coverage of the 2014 Top 100, be sure to check out the December issue of Boating Industry.
Search our inventory by store, brand, length, price, lifestyle and much more. Finding the boat of your dreams has never been this easy!
Find the MarineMax store closest to you to learn more about our great incentives on our premium brands, and to become part of the MarineMax family today!


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In case you haven't already seen it, there's a video making its rounds on the web that purports to show a hunter snagging a quail right out of the air with his bare hands as it zooms past—much to the amazement of his buddies. It's embedded below. The real question, though, is whether or not the events in the video are legitimate. Being that I'm skeptical of just about anything that "goes viral," it's no surprise that I have little faith that the events depicted in the video were a completely random and coincidental event. Whether the whole thing was staged, or simply a matter of fancy CGI work—like that "eagle" that allegedly tried to make off with a baby a few months back—I'm not buying it. Here's why:
1. Playing it too Cool
2. The Video's too Perfect
3. The Obligatory Self-Promotion
McCoy himself makes little more than a cameo in the video, offering only a chuckle and the compliment of "sweet catch." Seriously, Colt? If this whole thing is legit, your buddy just made a better catch than any receiver you had on the Browns ever did. Give me more enthusiasm.
That all said, maybe I'm being entirely too skeptical. Watch the video below and make your own call. Did this guy make the catch of the year?


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POSTED: Wednesday, December 19, 2012 - 5:30pm
UPDATED: Wednesday, December 19, 2012 - 5:34pm
Baton Rouge, La (NBC33) — Catholic Charities of Baton Rouge says charitable donations are at an all-time low.
Communications Director Carroll Spruell says donations to Keep Christmas Lights Shining Bright are down close to 60 percent compared last year.
The program, which helps families in need pay utility bills and other services, is in dire need of donations.
"Whether it's the talk about the fiscal cliff, we don't know," stated Spruell. "But whatever it is, these families who are calling us, they live on the edge of the cliff every day. Just keeping food on the table is a challenge for them."
Spruell says all of the families sponsored for the holiday have been adopted. She went on to say until just last week there were still 100 sponsored families in danger of missing out on any type of Christmas.
For more information on Catholic Charities of Baton Rouge, click here. [1]


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Posted by: FCS
03 August 2012
Wayne "WIZ" Rickards is one amazing individual. I first discovered this talented resin master at Barry Bennett's in 1972, where he was the glasser, laminating my first Bluebirds. He amazed me as the first "roller" glasser who applied and wet out the glass cloth using a paint roller!! Perfect workmanship!