text:
Day In a Page
Saturday, 10 January 1998
Jump to:
News RSS Feed - click to grab the feed- No welfare 'big bang'
- Liberals split on Cabinet job
- Angry wife defends Cook
- I could still be prime minister, says Brown
- And the forecast is more to come
- It shouldn't happen to Yvette
- Former Dome chief attacks 'Stalinist' Mandelson
- Welsh fall behind on siting Assembly
- Charities target the rich
- Blair Babe Brinton stung by derision cyber jibe
- Earth facing exhaustion as economies hit historic levels
- Danny boy's new love: the left hook
- How one man's passion saved the Bosnian bee
- My mother taught with 'lady in lake'
- Burchill is back - with a vengeance
- Get technical girls - it's child's play
- Cloning
- Labour choice to run Arts Council sparks row before he even starts
- Japanese offer is too little, too late, say former PoWs
- Letter reveals Mandelson as double agent
- UK moves closer to cloning of humans
- Students move into Wren's masterpiece
- Give Diana fund cash to mine manufacturers - MP
- Wool is back - and so is the hungry clothes moth
- Women afraid to ask for emergency Pill
- Althorp locals fear summer tourist invasion
- Hunt for dead author Dan Farson's life of the artists
- Hitch Hiker's Guide to be a movie
- Cult fear as stars make new Friends
- Hague calls for inquiry into Welsh referendum vote
- Germany isn't working and Kohl is in a fix
- Advertising: Cricket may get Tango'd in bid to ditch stuffy image
- Environment: Chefs feel heat as mushrooms go on conservation menu
- Environment: Britain basks in warmest winter day for decades
- Advertising: Radio watchdog on guard as Evans talks up his sponsors
- Man dies in Basque blast
- Jobless scorn Jospin's aid offer as cracks begin to show in coalition
- Eurocrats: Take the test to find out if you've got what it takes to get a job in brussels
- Eurocrats: Blair backs Britain to run the show
- Only masculine ministers allowed in the French Cabinet
- Arts: Comfort and coffee in book megastores
- Arts: Millennium Dome's new setback as style guru resigns
- Arts: Battle breaks out over dead poet's final resting place
- Arts: Music chief quits at `dumbing down'
- Devolution: Dewar's patriot game wins battle over home for Scots MPs
- Shelling out
- Devolution: Home sought for Welsh Assembly
- S Leone job for ex-envoy
- Mermaid's head returned
- US air traffic controllers forced to use pen and paper
- Observers endorse Kenyan elections
- Cult leader `had chemicals'
- Blair says reforms will go Full Monty
- Moscow murder
- Diplomacy: Dissident fears Cook puts business before ethics
- Diplomacy: He's clever, but has the man in the Foreign Office got a heart?
- Science: A warm glow from the universe's distant past
- Diplomacy: His wife decides to put things straight
- Mother found guilty of child abuse after death of 49-stone daughter, aged 13
- Science: The end is nigh ... but not for a while
- Science: Kraken or tree trunk? Mystery blob from the deeps confounds the experts
- Motoring: Alarm over elderly drivers
- Millionairess is first lady of the theatre
- Raped Austrian tourist to marry police counsellor
- Maze prison officers warned over terror attack
- Cambridge professor rebuked for homeless jibe
- Mo persuades the hard men to keep talking
- Crime: Licence-evaders' festive excuses
- Health: Gums link to heart disease
- Getty lawyer to head C4
- Nikki Sand in love split
- Branson's Lottery libel case takes off
- PM's wife to oppose unions on pensions in House of Lords
- Muslim schools win historic fight for state funding
- Brown book fuels fresh bitterness
- Politics: These modern nuptials are so New Labour
- Travel: Lowest fares ever tempt travellers to the Far East
- Politics: Labour denies plan to end pageantry
- Briton shot in Brazil
- Travel: But political unrest could pose trouble
- Travel: Meltdown makes Asia a paradise for tourists
- Court challenge for toll road
- Broker nabs ex-Yamaichi team
- Tea time is up for London auctions
- GEC plays defensive game
- When the world's financial stabiliser crumbles...
- Sidlaw wraps up profits
- HK dollar is next in firing line
- Briton looks to create power vacuum in Japan
- Smart moves: The millennium bug brings rich pickings
- Time runs out for the gravy trains
- Deflation effect kicks in
- Asia fallout reaches Wall Street
- Smart moves: Mixing and matching
- Three wise men and one crystal ball ...
- Smart moves: Stand in line for quality graduates
- Smart moves: Directors 'blind' to impact of restructuring on employees
- Master of the big cats
- In a league of their own: join the private powers
- Jittery exporters dent stocks
- 2001, a business strategy
- New words spell out a new world order
- Spotting winners in the year ahead
- Mystery bidder values Sketchley at pounds 70m
- Smart moves: Toughen up and beat the bully
- IPC set to grow after sale
- Asia may spur world slump, warns Soros
- Bonds issue is music to V2
- Tidal wave of selling hits Wall Street as fears grow over Asian crisis
- EMU odds continue to shorten
- Don't count on a happy ending for markets
- Toyota's expansion could herald car investment boom
- No price cuts yet for British Gas's low-income customers
- Scottish & Newcastle supply monopoly blow cheers beer drinkers
- Waterstone set to regain book empire
- Hong Kong investment bank rescue falls through
- Managers buy back RJB mine
- Wall Street and London fall as US job figures revive inflation fears
- Sketchley rejects mystery bidder
- Former Volkswagen chief seriously hurt in car crash
- John Lewis signals a good start to winter sales
- BT considers huge investor payout as directory bills soar
- Market Report: Footsie suffers as gloom spreads from the Far East
- Market Report: Taking Stock
Business RSS Feed - click to grab the feed- Broker nabs ex-Yamaichi team
- Tea time is up for London auctions
- GEC plays defensive game
- When the world's financial stabiliser crumbles...
- Sidlaw wraps up profits
- HK dollar is next in firing line
- Briton looks to create power vacuum in Japan
- Smart moves: The millennium bug brings rich pickings
- Time runs out for the gravy trains
- Deflation effect kicks in
- Asia fallout reaches Wall Street
- Smart moves: Mixing and matching
- Three wise men and one crystal ball ...
- Smart moves: Stand in line for quality graduates
- Smart moves: Directors 'blind' to impact of restructuring on employees
- Master of the big cats
- In a league of their own: join the private powers
- Jittery exporters dent stocks
- 2001, a business strategy
- New words spell out a new world order
- Spotting winners in the year ahead
- Mystery bidder values Sketchley at pounds 70m
- Smart moves: Toughen up and beat the bully
- IPC set to grow after sale
- Asia may spur world slump, warns Soros
- Bonds issue is music to V2
- Tidal wave of selling hits Wall Street as fears grow over Asian crisis
- EMU odds continue to shorten
- Don't count on a happy ending for markets
- Toyota's expansion could herald car investment boom
- No price cuts yet for British Gas's low-income customers
- Scottish & Newcastle supply monopoly blow cheers beer drinkers
- Waterstone set to regain book empire
- Hong Kong investment bank rescue falls through
- Managers buy back RJB mine
- Wall Street and London fall as US job figures revive inflation fears
- Sketchley rejects mystery bidder
- Former Volkswagen chief seriously hurt in car crash
- John Lewis signals a good start to winter sales
- BT considers huge investor payout as directory bills soar
- Market Report: Footsie suffers as gloom spreads from the Far East
- Market Report: Taking Stock
Education RSS Feed - click to grab the feedEducation News
- Football: United in no mood to show strugglers any mercy
- Rugby Union: `No question: he was a world class centre'
- Football: Stevenage given go-ahead to stage their dream tie
- Rugby Union: Carling retires - reluctantly and with a hint of rancour
- Football: Black and white highlights: Dalglish's first year at Newcastle
- Football: God's own coach on a mission of mercy for the lad Heckinbotto m
- Sidelines: Ten things that Spurs' David Ginola might be missing in his home village of Gassin this weekend
- Football: Kendall slates Spurs over transfer rebuff
- Sidelines: History Lesson
- Football: Emerson staying at Boro
- Sidelines: Old Boys reunion for Foxes and Villans
- Football: Keane out for rest of the season
- Football: Wimbledon's failure to surprise is the big surprise
- Sidelines: This Week
- Football: Tottenham's taskmaster? It's all a Gross distortion
- Football -Scottish League: Farry prepared to punish Gascoigne
- Cricket: Guyana Test may be switched
- Football: Fan's Eye View no 239 - Georgi Kinkladze: Georgian genius wit h an empathy for bitter rivalry
- Sport on TV: Bullimore plays himself as nightmare scenario sees Bruce W illis meet The X Files
- Rugby League: Tunnicliffe sets out agenda for tenure
- Rugby Union: Pugh confident of resolving `little spat' with English clubs
- Rugby Union: Woodward quickly recruits Guscott
- Tennis: Rusedski takes a rain-check
- Football: Toon Army dreams of absent friend as thrills turn to chills
- Days Out: `You are old, Father William' - 100 years old, in fact
- Gardening: A touch of glass
- Rural: The ill wind that brought a countryman no good news
- Indoor: Leafy ways to floral beauty
- Photo-shoot: Golf - Amateurs fly the flag
- Promotion: Incredible flight offer: Europe from pounds 34 return
- Racing: The former National Hunt jockey Steve Smith Eccles (right) gives an analysis of today's Ladbroke Hurdle.
- Outdoor: Unloose the dogs of squelch
- Sailing: Our longest day ends in sweet victory
- Outdoor: A Cornish cream of a train ride
- Running: Avoiding many of the sheep droppings, I perform desultory stretching exercises
- Indoor: Bridge
- Indoor: Backgammon
- Surfing: My claim to free cocaine was based on Walrus' belief that I ha d starred in the film of Scarface
- Sailing: Smith needs a leg up after another limp performance
- Basketball: Tresvant takes a Giant step
- Sport on the internet: Super Bowl's silver service
- Swimming: Chinese stand firm over drugs disgrace
- Hockey: Dancer splits squad in two
- Racing: Sherwood knows how good Him Of Praise is but the handicapper has yet to find out
- Racing : Eddery's back: that means a new challenge not an old crisis
- Racing: The A-Z Of Betting - Q is for . . .
- Russia: 48 hours in the life of St Petersburg
- Russia: Where Lenin meets Buddha
- Mystery, history and the spirit of survival
- Skiing: Simon Calder
- Skiing: Fighting the frost in Canada
- Scotland: In the kingdom of Dalriada
- Football around the world
- Sporting Digest: Rugby Union
- Sporting Digest: Football
- Quotes of the week
- Sporting Digest: Cricket
- Football: This Week's Transfers
- Football: Emerson staying at Boro
- Travel: Red channel
- Green channel
- Chess
- Games people play
- Racing: Hyperion's Tv Tips
- What, when, where ...
- Nature Note
Voices RSS Feed - click to grab the feed- 'The ship looked like an enormous toy full of lights'
- Letter: Boys and girls
- Letter: Biafra's tragedy, Britain's shame
- Letter: Happy to pay
- Letter: They need help, not barbed wire
- Letter: Docklands has a bright future
- Letter: Unjustly dim view of Israel
- Learn to let go, Tony, and use the Cabinet
- Letter: Lottery applicants should seek advice from their council first
- A rabbit out of his hat
- The perfect game for obsessives and depressives
- Without the poor of the world, where would the rich world be?
- Leading Article: No more talk of Asian values
- Carp not, you who know little of unhappy aristocrats
- Good excuse to clean up
- Make way for Mayor Patten
- America's curious concept of freedom
- Letters: Briefly
- Letter: Tories and Europe
- Letter: Plans for `Britannia'
- Hallelujah! At last the Government has seen the light, if not the Beeb
- Not all that comes out of the sea is just a blob of blubber
- Letter: Millennium doom
- Letter: Nanny in the family
- Letter: Bootleg Stones
- Letter: Squalid public
- The winning and losing ways of Will Carling - rugby's first superstar
- Letter: Artistic suede shoes
- Letter: Cure for congestion
- Letter: Out to lunch
- Leading Article: Eternity is an ever-expanding idea. And so is that Dome
- Letter: Self's the man
- Letter: Tories and Europe
- Letter: Cure for congestion
- Letter: Millennium doom
- Letter from the editor
- Quote unquote
Sport RSS Feed - click to grab the feed- Cricket: England's high hope in Jamaica
- Snooker: A match too far in Fu's long march
- Football: Overmars hosts homecoming party
- Football: Adams fit to face the world
- Football: Forest fired by Van Hooijdonk
- Football: Adams: Why I thought about quitting the game
- Football: Rematch for Bobby and the Kaiser
- Football: Giggs deepens Gross gloom
- Football: Price fear for Stevenage tie
- Football: Derby's rare mix of style and guile
- Football: Brolin bows to Madar
- Football: Game needs saving from itself sometimes
- Rugby Union: New ground swell on Tyneside
- Rugby Union: Wood bursting to be Quins' driving force
- Rugby Union: Carling a victim of modern puritans
- Football: Newsome gruesome for Toon
- Football: Redknapp restores the belief
- Football: Jones the saviour
- Football: Hartson heartens
- Football: Nicholls makes Chelsea benchmark
- Football: Milan mind the gap
- Football: Joachim gives Little respite
- Football: Laudrup and clear
- Football: The Valley of cheers
- Rugby Union:Leaders look to pull clear
- Rugby Union: Clubs cutting their own throats
- Hockey: England draw after disastrous start
- Rugby Union: Alexander's brag time
- Cricket: World championship "on the cards"
- Rugby Union: Hands-on Brewer
- Cricket: Muralitharan makes Zimbabwe suffer
- Rugby Union: Grayson rings the changes
- Rugby Union: Good thing Howley
- Golf: Americans side by side after rain
- Rugby League: Citing for 'biting' threatens Bath
- Racing: Royston Ffrench...Yet Again
- Skiing: Ormond's full-time training pays off
- Rugby Union: Stransky shows the gulf
- Tennis: Agassi beaten by Australian teenager
- Sailing: Local hero Dalton rides his luck
- Cricket: The England file
- Sailing: Wounded by a low blow
- Cricket: Bluey and Arnie: the everlasting bond
- Cricket: The West Indies file
- Snooker: My fight for future of snooker
- Boxing: 'Misfit' who would be King
- Tennis: The Lucic set ahead of their years
- Golf: Lee in high company after the lows
- Rugby League: Sailor's tale of the times for Wigan
- Lady brings the Blues out of their deep slumber
- Swimming: China delay sending Yuan home
- Racing: French Holly shines as Shot runs flat
- Cricket: Warnings from Lara and Walsh
- My travels down desolation road
- Angling: A state of complete dismay
- Cricket: Warne the original one-off
- Tennis: Rusedski and Henman blow out
- Rallying: Paris-Dakar competitors attacked
- Cricket: Relaxed and calm before the storm
- Swimming: In the shadow of the cheats
- Cricket: In the name of the father
- World must guard against this vial habit
Life and Style
Life and Style RSS Feed - click to grab the feed- Noblesse oblige, and all that jazz
- Thank you for the music
- Let's get cerebral
- Mother's pride takes to the billboard
- Postcard from New York: Walkers of the world unite
- Have these dieters got their combinations in a twist?
- No more Mister Fat Guy
- Two in the bed and the little one said, roll over
- Bore yourself thin
- Capital gains and losses
- A film to remember
- Why are they famous? Anthea Turner
- If you want to get ahead, get a hat
- The sounds of snow and silence
- TIME OUT: City Guides; CITIES AT A GLANCE
- Dreyfus: the name of our century
- Can pay, but will pay? A day in the life of the Heathrow honesty boxes
- Crisis over... next crisis?
- Three days that shook and moved the peace process
- Honesty gets a trial run
- Letters: Cannabis Campaign
- Cannabis Campaign: Gotcha! Sun splatters egg on its face with telephone poll
- Incredible flight offer: Europe from pounds 34 return inc. tax
- YOUR CHANCE TO WIN a WORK OF ART
- Eternal City's great Millennium show is up the Tiber without a paddle
- Danger that strikes from a clear blue sky
- Eins, zwei, drei, have a nice day - Germans learn service with a smile
- Europe finally roused by Algeria agony
- You try Cornwall, we'll try Bolivia
- South Africa rocked by killings at the Cape
- Fight goes on for survivors of Japan's prison camps
- Tigers' critics foresaw crisis
- In modern Peking, money squawks
- Amazing turn on the road from Kyoto
- THE DIARY OF Emma D May: Not a patch on nicotine
- The Intelligent Consumer: With all the trimmings
- The Intelligent Consumer: Why blondes have more funds
- The Intelligent Consumer: You're gonna reap what you faux
- A cook's tour
- Good Venue Guide: 14; ROYAL ALBERT HALL, SW7
- Travel: Don't miss your last chance to win the trip of a lifetime: watch the dawn of a new age on the other side of the world
- Counselling: auntie ag and uncle ony
- Going Out: RECOMMENDED
- Flat Earth
- Plant of the moment
- TIME OUT: City Guides; CITIES AT A GLANCE
- The Intelligent Consumer: Fandango
- TIME OUT: City Guides; CITIES AT A GLANCE
- 5 days in the life of ...
- Percentage points
- In the name of the father
- The Big Picture: Precious rice harvest makes India's winter turn gold
- Photography: Embroidery in the morning, death in the afternoon
- Film: Free radical
- Literature: In the middle of a chain reaction
- Box Clever: Motormouth strikes again
- Postcode From The Edge: Rock down to Electric Avenue
- Art: Bath rooms
- Pop: A Fiercely competitive business
- Comedy: The shadow cabaret
- Dance: New Year's Resolution
- Restaurants: Notting Hillbilly
- After Dark: Brixton thrills
- Visual Arts: The Katz whiskers?
- Classical & Opera: The master debutant
- Flat out
- Motoring: My Worst Car Chas McDevitt's Ford Sierra Estate
- Theatre: Going liberal on the drama
- Cooking With Attitude: Out west and down under
- Food: Root treatments
- Motoring: Beetles top the Motown charts
- Food & Drink: CFN
- Drink: Heavy gravity, man
- Books: Items and Icons books
- Book: Sweeney erect
- Console Review: Nightmare Creatures
- Ain't no mountain high enough
- Property: A little bit like Belgravia
- Motoring: Road test: Daihatsu Cuore
- Net Gains: Have you heard the one about...?
- Book: Theory of rubbish
- Book: The end of the run
- Property: Tide changes for overseas property
- Console Review: Mischief Makers
- Property: International properties/ three to view and why buy now
- Property: The beastly buyers who ask to enter early
- Property: When the minimalist's loft space presents a minor problem
- Property: Short on space? Welcome to the fold
- Cafe Society: A cordial welcome
- Personal Finance: The lure of cheap markets
- Property: How to break into home ownership without raiding the bank
- Book: Warts in Vienna
- Watch London mime festival
- Cafe Society: Noodles bar none
- Personal Finance: Avoid being mauled by the tiger economies
- Arts: Tumbling, flying, twirling with ease
- Arts: There are 499 stories in the ever expanding world of opera. This has been one of them...
- Wide Angle: Tapping a rich vein
- Tales from the crypt
- Personal Finance: Time for a tax-form amnesty
- Personal Finance: A lesson to learn about the pension
- Personal Finance: A case of luggage fetishism
- Hidden treasures in the money maze
- Personal Finance: Under the spotlight/GT Global's UK Key trends fund
- Book: The Knack How to breathe, by Cheryl Isaacson
- Get a haircut
- Learn about dinosaurs
- Personal Finance: So, have the experts anything to be proud of? Well, yes
- Corset still makes sense
- Personal Finance: The art of self-defence for investors
- Personal Finance: Home loans on-line
- Personal Finance: Doubling the shares doesn't double the money
- Personal Finance: To profit from endowments you need a policy of no surrender
- Personal Finance: How to weather storm damage to your property this win ter
- Personal Finance: The danger of being too bullish
- My lofty life
- Outtakes
- Arts: The week on radio
- Arts: A week in the arts
- The Weasel
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- Personal Finance: Bargain basement
- Books: Independent choice
- Books: Spoken word
- Books: Paperbacks
- A week in books
Arts and Entertainment
Arts and Entertainment RSS Feed - click to grab the feed- DANCE: A sense of deja vu and going round in cirques
- CINEMA: Wenders without the Wim
- RADIO: Get Pachelbel out of the canon - now!
- CRIES & WHISPERS: Hello, hello, good to be back
- A composer of our time
- TELEVISION: Counsel for the prostitution
- JAZZ: Sun Ra: a perfect orbituary
- Finally, proof that there is life after death
- Travel Special: REMOTE POSSIBILITIES
- Travel Special: ACTION PLAN
- Travel Special: JOURNEY INTO RUINS
- Yin, yang and Yen
- I'm no Einstein, but one day he might be
- THEATRE: Ridiculous, but quite sublime
- MUSIC: Cinderella instruments get to go to the ball (just this once, mind)
Travel RSS Feed - click to grab the feed- Travel: For as little as ...
- Travel: It gets wild in Somerset at this time of year
- Travel: The Disaster Tourism club: a new fashion for 1998
- Travel: A short stay in... Zagreb
- Travel: Where to find the best dives - and the best deals
- Travel: Under water and out of this world
- Passport: Hilary Bradt - 'The villagers were very kind and welcoming, and fed us a meal of roasted weevils'
- Travel: Forget the beach - try a tomb with a view
- Travel: Literally lost: 16
- My Rough Guide: Brazil - Lunch is served: half a dozen piranha fish in soup
- Travel: Your holiday romance
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- Travel: Your questions answered by our panel of travel experts
- Travel: Beam me down, Scotty
- Travel: Books of the week
- Travel quote
- Travel: What's on worldwide
- Travel: Brochures of the week
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text:
Original Article
Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation
Article first published online: 30 DEC 2003
DOI: 10.1053/jhep.2001.28189
Copyright © 2001 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Dandri, M., Burda, M. R., Gocht, A., Török, E., Pollok, J. M., Rogler, C. E., Will, H. and Petersen, J. (2001), Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation. Hepatology, 34: 824–833. doi: 10.1053/jhep.2001.28189
Publication History
- Issue published online: 30 DEC 2003
- Article first published online: 30 DEC 2003
- Manuscript Accepted: 27 JUL 2001
- Manuscript Received: 20 APR 2001
Funded by
- Deutsche Forschungsgemeinschaft to J.P.. Grant Number: PE /608 2-3
- EMBO long-term fellowship to M.D.
- Irma T. Hirschl-Weiler trust to C.E.R.
- Freie und Hansestadt Hamburg and the Bundesministerium für Gesundheit, Germany.
- Abstract
- References
- Cited By
Isolated hepatocytes represent a relevant model of the liver and are highly required both for research and therapeutic applications. However, sources of primary liver cells from human beings and from some animal species are limited. Therefore, cryopreservation of hepatocytes could greatly facilitate advances in various research areas. The aim of this study was to evaluate whether cryopreserved primary woodchuck hepatocytes could be used for woodchuck hepatitis B virus (WHV) infection studies, and whether they could maintain their regenerative potential in vivo after thawing. Critical steps for good quality of cryopreserved hepatocytes included the use of University of Wisconsin (UW) solution as a main component of the freezing medium, stepwise reduction of dimethylsulfoxide (DMSO) to avoid osmotic shock, and maintenance of low concentrations of DMSO in the culture medium. After cryopreservation, cell viability was still high (70% to 80%), and 50% to 60% of thawed cells attached to the plates. The appearance of covalently closed circular (ccc)DNA and of WHV-replicative forms a few days after in vitro infection demonstrated that thawed woodchuck hepatocytes were still susceptible to viral infection, thus proving maintenance of a very high hepatocyte-specific differentiation status. Furthermore, transplantation of woodchuck hepatocytes into the liver of urokinase-type plasminogen activator (uPA)/recombination activation gene-2 (RAG-2) mice, a model of liver regeneration, demonstrated that cryopreserved cells retained the ability to divide and to extensively repopulate a xenogenic liver. Notably, in vivo susceptibility to infection with WHV and proliferative capacity of frozen/thawed woodchuck hepatocytes in recipient mice were identical to those observed by transplanting fresh hepatocytes.

subset: commoncrawl


text:
Little library in Aspinwall promotes literacy
Janet Rohrer is doing her part to encourage people to read.
Rohrer installed a "Little Free Library" at her Aspinwall home on Third Street earlier this month. The house-shaped cabinet, which was built by her handyman Bob Sipple, sits outside her home and is filled with books for people to take.
The books are part of the Little Free Library program. The Wisconsin-based organization promotes literacy through stands with books in towns around the world. Currently, 17 are registered in Pennsylvania.
In the first few hours Rohrer had the library stocked with books, five were taken.
"Since then there has been a constant, people coming and taking the books," she said.
Books taken from the Little Free Library don't have to be returned, Rohrer said. It is currently filled with her own books and some donations.
"They can (bring books back) if they want, they can bring another book to put in or not," Rohrer said.
The library has a variety of genres, including children's books, fiction and cookbooks. As the books are taken, Rohrer will replace them.
"It's impossible to steal them because they are to give away," Rohrer said.
Once Rohrer's library is registered with the main Little Free Library organization, it will be placed on a map on its website.
It also will be eligible for books from various publishers.
With the library down the street from St. Scholastica Catholic Church, Rohrer expects a lot of foot traffic passing her home. She has met new people from the neighborhood since she first installed the library.
"People I've never seen or never talked to, now we'll chat because of this," Rohrer said.
Rohrer said she hopes the library promotes literacy and encourages people to share books they've enjoyed.
"We all have so many books just lying around, how wonderful to pass them on," Rohrer said.
For more information on "Little Free Library," see www.littlefreelibrary.org.
Tom McGee is an associate editor for Trib Total Media. He can be reached at 412-856-7400, ext. 1513 or firstname.lastname@example.com.
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Winnipeg Free Press - ONLINE EDITION
Arrest warrant law aimed at withholding driver's licences slow to start
Legislation tabled three years ago to withhold a driver's licence and vehicle registration from offenders with outstanding arrest warrants remains a work in progress, Justice Minister Andrew Swan said Thursday.
His admission came after Progressive Conservative justice critic Kelvin Goertzen raised the matter in question period, claiming the Selinger government was dragging its heels on the public safety file.
Goertzen said it appears the government has failed on a second initiative to withhold welfare payments from people with outstanding Criminal Code warrants. There are about 20,000 outstanding warrants in the province, though a person can be wanted on more than one warrant.
"This is actually a debate that's been going on for five years," Goertzen said outside the house. "I don't think taxpayers should have to fund individuals who are avoiding the law and possibly causing a danger to society."
Swan said in June 2011 that the government would streamline police access to information in provincial databases to track down and apprehend individuals with outstanding warrants.
The access would enhance the work of a newly created joint Winnipeg police and RCMP police warrant enforcement unit, he said at that time.
Swan said Thursday that to date, the seven-member unit has executed about 2,000 warrants and brought 1,400 people into custody, but that officials only have access to the province's welfare rolls to run names.
Swan said about 30 people who've applied for or already receive employment and income assistance (EIA) have been flagged each month since December 2012 for having an outstanding warrant.
"All but three people who've been flagged by EIA have actually gone and done exactly what we want them to do," Swan said. "It's proof that people are taking it seriously and dealing with warrants."
Under the program, people who get EIA are required to deal with outstanding warrants to prevent benefits from being cut off. Provisions are in place to minimize the impact on family members. If two or more people are in the household, there will be no cut to basic benefits for rent, utilities and health care. Eligibility is reinstated once a person confirms outstanding warrants have been cleared up.
Swan said the legislation to withhold driver's licences will be proclaimed and enforced "in the near future" as soon as courts and Manitoba Public Insurance databases can be properly linked.
"Unfortunately, that has required some additional system changes," he said. "There has to be a proper flow of information and unfortunately it's taken longer to get those systems in place as we would have liked."
Goertzen said it shouldn't be that difficult to link databases.
"Everything seems to be difficult for this government," he said. "I don't think this government has ever had a commitment to this legislation. I don't think they've even taken the issue of outstanding warrants seriously."
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Iron oxide nanoparticles are described for usage in therapeutic hyperthermia as well as for magnetic particle imaging and spectroscopy (MPI, MPS). Application of those particles in hyperthermia therapy (injection into tumor cells and exposure to an alternating magnetic field to damage tumor cells) is well known whereas MPI is a quite new tomographic imaging technique based on the non-linear magnetization behavior of superparamagnetic iron oxide nanoparticles (SPIOs). So far it is clear that MPI will have potential for many different diagnostic applications but it is still lacking appropriate SPIO tracers to achieve and guarantee the best possible image quality.

 Technology
 The newly synthesized SPIO tracer for MPI according to this invention are assumed to have properties that guarantee a very well image quality and moreover enable them to be used in various biological systems and therewith in preclinical and clinical development. The SPIOs are provided as magnetic particle dispersion comprising single- or multi-core nanoparticles of iron oxides like magnetite and/or maghemite. For in vivo applications and stabilization the particles are coated with a biocompatible shell, preferably a polymer. In first experiments the dispersions showed an improved nonlinear magnetization behavior and a distinctive overtone structure that are clearly superior to SPIOs known in the state of the art so far. Moreover these SPIOs show improved heating properties when subjected to an alternating magnetic field. The proposed SPIO dispersions are suitable for applications in MPI, MRS, MRI, hyperthermia therapy, cell tracking and diagnosis of tumors, cardiovascular-, bone marrow-, lymph node- or liver diseases.

email@example.com | TechnologieAllianz e.V.
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text:
In 2009, ChipMOS Technologies (Bermuda) imos 0.5550811272416738% ChipMOS TECHNOLOGIES Bermuda Ltd. U.S.: Nasdaq USD23.55 0.13 0.5550811272416738% /Date(1425592800235-0600)/ Volume (Delayed 15m) : 82585 AFTER HOURS USD23.5581 0.0081 0.034394904458598725% Volume (Delayed 15m) : 200 P/E Ratio 18.69047619047619 Market Cap 697915984.405517 Dividend Yield 0.5944798301486199% Rev. per Employee 114878 More quote details and news » almost collapsed after two of its top customers, which together accounted for 40% of its revenue, went belly up. Today, it is positioned for growth that could boost its shares by 30% from current levels. And they have already doubled this year.
The small semiconductor assembly and testing outfit's remarkable comeback is being fueled by some of the hottest markets around, including smartphones, tablets, and vehicle infotainment systems.
Established in 2000, ChipMOS bases its operations in Taiwan. (Its holding company, however, is located in Bermuda; hence the name.) ChipMOS (ticker: IMOS), along with Chipbond Technology (6147.Taiwan), are the main players in the global test-and-assembly industry. The company, which has a stock-market value below $500 million and annual sales of around $600 million, processes, checks, tests, and modifies silicon wafers produced by Taiwan Semiconductor Manufacturing tsm 0.5343197698314838% Taiwan Semiconductor Manufacturing Co. Ltd. ADS U.S.: NYSE USD24.46 0.13 0.5343197698314838% /Date(1425592942097-0600)/ Volume (Delayed 15m) : 6789694 AFTER HOURS USD24.45 -0.01 -0.04088307440719542% Volume (Delayed 15m) : 92725 P/E Ratio 14.616947531970839 Market Cap 124253619088.786 Dividend Yield 2.041915780866721% Rev. per Employee 651908 More quote details and news » (TSM), Intel INTC -1.1430246189917936% Intel Corp. U.S.: Nasdaq USD33.73 -0.39 -1.1430246189917936% /Date(1425592800383-0600)/ Volume (Delayed 15m) : 20833309 AFTER HOURS USD33.71 -0.02 -0.059294396679513785% Volume (Delayed 15m) : 392498 P/E Ratio 14.054166666666667 Market Cap 161592314941.406 Dividend Yield 2.846131040616662% Rev. per Employee 523618 More quote details and news » (INTC), Fujitsu 6702.TO 2.966442953020134% Fujitsu Ltd. Japan: Tokyo JPY767.1 22.1 2.966442953020134% /Date(1425674849000-0600)/ Volume (Delayed 20m) : 17599000 P/E Ratio 16.207479399957744 Market Cap 1498693122500 Dividend Yield 1.0428888019814888% Rev. per Employee 29401100 More quote details and news » (6702.Japan, Texas Instruments TXN 0.03429355281207133% Texas Instruments Inc. U.S.: Nasdaq USD58.34 0.02 0.03429355281207133% /Date(1425592800103-0600)/ Volume (Delayed 15m) : 3602654 AFTER HOURS USD58.34 % Volume (Delayed 15m) : 83160 P/E Ratio 25.329975686002083 Market Cap 61069319240.9845 Dividend Yield 2.3311621528968116% Rev. per Employee 420766 More quote details and news » (TXN), Himax HIMX -3.5714285714285716% Himax Technologies Inc. ADS U.S.: Nasdaq USD7.29 -0.27 -3.5714285714285716% /Date(1425592800123-0600)/ Volume (Delayed 15m) : 2499238 AFTER HOURS USD7.49 0.2 2.7434842249657065% Volume (Delayed 15m) : 23640 P/E Ratio 18.827479338842974 Market Cap 1294366444.06056 Dividend Yield 3.7037037037037037% Rev. per Employee 509555 More quote details and news » (HIMX), Micron Technology MU 0.051255766273705795% Micron Technology Inc. U.S.: Nasdaq USD29.28 0.015 0.051255766273705795% /Date(1425592801674-0600)/ Volume (Delayed 15m) : 23299082 AFTER HOURS USD29.36 0.08 0.273224043715847% Volume (Delayed 15m) : 708653 P/E Ratio 8.438040345821326 Market Cap 31527563944.5111 Dividend Yield N/A Rev. per Employee 555559 More quote details and news » (MU) and other customers, and assembles them into components for use in electronic devices.
THE COMPANY'S WOES stemmed from an expansion spree that left it heavily in debt, just as the 2008-2009 financial crisis shook the global economy. Its stock, in the mid-$20s before the downturn, sank to a low of 18 cents in December 2008. "It was a very difficult time," Chief Financial Officer Shou-Kang Chen recalls in a telephone interview from the company's headquarters in Hsinchu. "Our expansion was predicated on contracts with our customers who were hurt badly by the recession, which was out of our control. But we were able to renegotiate our debt, spread out payments, freeze our capital spending, and generally weather the storm."
It also didn't hurt that 2010 saw the start of a turnaround for the semiconductor industry. Or that ChipMOS was able to collect $100 million owed by its biggest customer, Spansion CODE 1.8235451863770449% Spansion Inc. Cl A U.S.: NYSE USD37.97 0.68 1.8235451863770449% /Date(1425593001432-0600)/ Volume (Delayed 15m) : 1767623 AFTER HOURS USD37.97 % Volume (Delayed 15m) : 1774 P/E Ratio N/A Market Cap 2355870318.42224 Dividend Yield N/A Rev. per Employee 321314 More quote details and news » (CODE), which had gone into receivership.
"Because ChipMOS wasn't well known, even though it's listed in the U.S., many investors expected it to go bankrupt, as well," says analyst Richard Shannon with Craig-Hallum Capital in Minneapolis. "But because its business was basically stable, and it was only one of two players in its particular business niche, they were able to recover relatively quickly, moving from a negative 29 cents a share of free cash flow in 2010 to $4.24 in 2011, and toward an expected $3.60 in 2012 and $4.11 in 2013."
At a recent price of $12.63, ChipMOS stock was trading at less than four times this year's expected free cash flow, the metric "that really tells the story of how cheap the stock is, and is the best way to judge the true value of a stock like this," says Shannon. He rates the stock a Buy, with a 12-month price target of $26.
Comments Taz Turner, who runs the New York-based South Shore Capital Partners hedge fund: "Four dollars a share in cash flow this year and probably $5 next year is pretty hard to ignore. And earnings should start to rise in earnest this year, as the company works out from under heavy depreciation and debt left over from its overexpansion in 2006-2007. It's been kind of a Lazarus stock—back from the dead."
Management has focused on the strong demand for liquid-crystal displays for smartphones and tablet computers from customers such as Apple aapl -1.6570717286447798% Apple Inc. U.S.: Nasdaq USD126.41 -2.13 -1.6570717286447798% /Date(1425592800730-0600)/ Volume (Delayed 15m) : 55944511 AFTER HOURS USD126.16 -0.25 -0.19776916383197532% Volume (Delayed 15m) : 572635 P/E Ratio 16.92235609103079 Market Cap 748713074838.728 Dividend Yield 1.4872241120164544% Rev. per Employee 2153110 More quote details and news » (AAPL), Hewlett-Packard hpq -0.5557180462123428% Hewlett-Packard Co. U.S.: NYSE USD34 -0.19 -0.5557180462123428% /Date(1425593024406-0600)/ Volume (Delayed 15m) : 17977531 AFTER HOURS USD34 % Volume (Delayed 15m) : 247172 P/E Ratio 12.781954887218046 Market Cap 62481780090.4261 Dividend Yield 1.8823529411764706% Rev. per Employee 364560 More quote details and news » (HPQ), Toshiba 6502.TO 0.20618556701030927% Toshiba Corp. Japan: Tokyo JPY486 1 0.20618556701030927% /Date(1425674839000-0600)/ Volume (Delayed 20m) : 18938000 P/E Ratio 24.483627204030228 Market Cap 2062864601871.46 Dividend Yield 1.646090534979424% Rev. per Employee 33390200 More quote details and news » (6502.Japan), and Dell (DELL). The LCD business produced about 35% of ChipMOS' revenue last year, versus 22% in 2009.
Turner adds that "2012 could shape up to be a terrific year for this segment of the semiconductor business, and assembly and test capacity could become tight," given the demand created by Apple's iPad and iPhone, Amazon.com's amzn 1.3351797658862876% Amazon.com Inc. U.S.: Nasdaq USD387.83 5.11 1.3351797658862876% /Date(1425592800022-0600)/ Volume (Delayed 15m) : 2647730 AFTER HOURS USD388.3 0.47 0.12118711806719439% Volume (Delayed 15m) : 45788 P/E Ratio N/A Market Cap 177729046074.688 Dividend Yield N/A Rev. per Employee 577469 More quote details and news » (AMZN) Kindle e-reader, smartphones using Google's goog 0.3418386033451349% Google Inc. Cl C U.S.: Nasdaq USD575.33 1.96 0.3418386033451349% /Date(1425592800234-0600)/ Volume (Delayed 15m) : 1357570 AFTER HOURS USD576.2 0.87 0.15121756209479778% Volume (Delayed 15m) : 28248 P/E Ratio 28.3899078720769 Market Cap 391934926070.48 Dividend Yield N/A Rev. per Employee 1228170 More quote details and news » (GOOG) Android operating system, and lightweight ultrabook laptops from a host of manufacturers.
ChipMOS marketers have also won new customers, such as Asahi Kasei Microdevices 3407.to 1.597051597051597% Asahi Kasei Corp. Japan: Tokyo JPY1240.5 19.5 1.597051597051597% /Date(1425674850000-0600)/ Volume (Delayed 20m) : 4547000 P/E Ratio 14.024872809496891 Market Cap 1701373662875 Dividend Yield 1.4510278113663846% Rev. per Employee 67916000 More quote details and news » (3407.Japan), which is aggressively expanding outside Japan and could be generating up to 5% of ChipMOS' sales by 2013.
With growing cash flow, the company is likely to be nearly debt-free by year end. Instead, it will have seven cents a share of net cash, versus a negative $2.86 for 2011, estimates Shannon. He sees net cash reaching $4.15 a share in 2013 and $7.22 in 2014.
At the same time, earnings are climbing. Shannon estimates that profits will be $1.85 a share this year and $3.00 in 2013, versus a pro forma 13 cents last year. The company reports first-quarter results on May 18.
Brian Grad, an analyst and portfolio manager with ChipMOS' top institutional shareholder, Bannockburn, Ill.-based DLS Capital, calls the company "massively undervalued." DLS has owned the stock for three years and holds 2.25 million shares, about 7% of the total outstanding. "You can make an argument that ChipMOS is a $30-plus stock…. The industry trades at a multiple of five times to six times and seven times at peaks. That would translate into a $31 stock" by year-end 2013, based on his cash-flow estimates.
THE STOCK ALSO LOOKS cheap on the basis of its price/earnings ratio—seven times expected 2012 net, in an industry that typically fetches 10 times forward earnings. On the same basis, its price-to-earnings growth (PEG) ratio is a modest 0.45.
Some shareholders expect ChipMOS to initiate a dividend eventually. The company will say only that it expects to have sufficient cash flow if its board ever wants to. ChipMOS already has authorization to buy back $10 million worth of its shares, but has difficulty doing so because of Nasdaq regulations.
A boon for shareholders could come if the company's main subsidiary, ChipMOS Taiwan, is listed in Taipei, as bulls believe it will be. ChipMOS Technologies (Bermuda) common, now listed on Nasdaq, would be exchanged for the Taiwan stock, which, in turn, would list American depositary receipts in New York on Nasdaq. The company says it "wouldn't rule out the option," but is noncommital.
Observes Scott Bishins, a Boca Raton, Fla., investor who owns about 1%, or 320,000 shares, of ChipMOS: "If ChipMOS were trading at the same valuation in Taipei as Chipbond currently is, it would be changing hands somewhere between $35 and $40."
Finally, ChipMOS's low price and good prospects could tempt an acquirer, although there's no indication that they have. But deal or no deal, investors who own the stock should eventually be in the chips.
E-mail: email@example.com


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The room was beautiful! Very comfortable bed, clean, staff was awesome. Breakfast was good!!
No complaints.
It is a very nice hotel sprawling public areas nice rooms.
The staff
No service at all. Worst 4 seasons experience we've ever had
Wonderful breakfast, close to freeway and shopping, friendly staff
Bathroom needed updating
I particularly like the pillows. I don't know where the hotel industry gets them, but I'm on a search for my own bed!
I liked the fact that the room had a small fridge & microwave to keep the kids waters cold for their soccer tournament the next morning and that breakfast was an option downstairs before our big day
The cleanliness of the room
The location of the building
Staff was attentive!
Check in/check out was easy. We were greeted by staff on entering and leaving every time. The food and service at the restaurant and bar were good. The room was attractive, well-appointed and comfortable in typical Hyatt fashion. TV was high quality HD flat screen with digital access. Hotel had convenient access to/from the 101 freeway.
The room overall was very clean, except under the desk, where little scraps of wire and dust balls indicated it had not been vacuumed in some time. Like a lot of older properties, plugs for iPads and phones were not convenient. Sockets on lamp bases would not accommodate chargers and there were no extra sockets around the desk (hence, my discovery of the detritus). Furnishings in the lobby area were sparse and austere. Clearly, you're not being invited to hang around the lobby and read.
Handsome clean rooms with crisp fresh white sheets and a comfortable bed. Four of us stayed four nights comfortably in one room.
Room was stylish and clean. Great location, close to freeway, markets and dining. Housekeeping staff were polite and friendly.
Person who checked us in was unfriendly and unhelpful. Not good qualities for the person who has contact with guests.
This isn't a Honeymoon hotel! However, it is a great place to bounce off of while visiting Ventura Harbor for The Channel Islands and surrounding activities. There is a mini fridge & microwave in the rooms & the breakfast has good selections.
No complaints
The hotel was very old and the room was supposed to be non-smoking but it wasn't. We ultimately ended up leaving.
The rooms were quiet. Staff was friendly and helpful.
The 'market' was very limited and some items had expired dates.
The hotel is clean. The room I stayed is bit small but comfortable and have a full kitchen.
I booked in May 2014 for a King-size bed room, but when I checked in on July 12 night, i was told the King-size bed was sold out. Then frontdesk staff gave a queen-size bed room for me/my wife and kid. I was confused why the pre-booked room be soldout.
Everything was clean.
No weather stepping on bottom of doors. Made the night very cold even with the heater on.
Great Value for the room ,located close to shopping
Low water pressure, stale smell in rooms
Excellent value. Great amenities: gym, bar & grill, pool, WiFi & wired internet access.
Water pressure was very low, making it difficult to shower. I understand conservation but I would prefer to make that a conscious decision rather than be forced by the plumbing.
Bathroom floor was not clean
Was clean, nice continental breakfast, comfortable beds.
The location was kinda sketchy for the price. You were a good hour at least from anything important.
Beautiful hotel with awesome service and great amenities. Just as long as you have a King bed, the queen beds are hard as rocks.
The beds were the most uncomfortable beds i have ever slept on. Extemely hard, my whole bosy was sore the next morning. You would sleep better if you slept on the floor.
The hotel was clean, the kids enjoyed the swimming pool and gym. The room was clean. We needed more towels and shampoo and the cleaning staff were great in providing those without hesitation
Unfriendly front desk staff, they need to go to training and learn how to be courteous. Like thanking the customer for staying at the hotel, smiling and hoping the customer enjoyed their stay. The staff did not even make an eye contact!
Voilà pourquoi :
Nous ne sommes pas un site marchand À KAYAK nous ne fixons pas les prix, il nous est donc impossible de garantir des produits et services vendus par d'autres compagnies.
Nous recueillons des données pour vous Notre site vous permet de comparer rapidement et facilement des centaines de sites de voyage à la fois. En ce sens, KAYAK est un moteur de recherche et nous ne pouvons garantir les prix que nous trouvons.
Pourquoi les prix ne sont-ils pas exacts à 100% ? Le prix des billets d'avions, chambres d'hôtels et véhicules de location varie fréquemment. Il est également probable que plusieurs personnes tentent de réserver la même option de voyage en simultané. C'est pourquoi il se peut qu'occasionnellement, certains prix ne soient plus disponibles.
Vous souhaitez plus d'informations ou avez trouvé une différence de prix? Contactez-nous N'hésitez pas à nous envoyer un email et un membre de notre équipe vous répondra dans les plus brefs délais.


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what does momentum mean? and is there any connection between it and kinetic energy?
Momentum meaning??
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momentum is mass (in kg) x velocity (in ms^-1)
ie: p=mv
yes, it has some relation to kinetic energy:
Ek = 1/2 mv^2
I'm not sure what level you're doing physics at? Basically momentum is why a leaf travelling at 10ms^-1 doesnt hurt you when it lands on you, and a bus travelling at the same speed would pretty much flatten you.
It's unit of measurement is Newton seconds, Ns.
I'm happy to go into it a bit more if you like... I'm doing A2 physics atm
xx -
A nice way to think about the physical meanings of momentum and kinetic energy is in terms of a car travelling along a motorway. If the car has to come to a stop, and this is done by slamming on the brakes and therefore applying a braking force (which we assume is constant), then the momentum of the car is a measure of how long (in time) it takes for the car to stop, while the kinetic energy is a measure of how far (in distance) the car travels before stopping.
In both cases, you get the actual stopping time and stopping distance by dividing the momentum and kinetic energy of the car by the (constant) braking force.
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Kevin Love
After long season with Suns Goran Dragic may not play in World Cup for Slovenia
Mar 25, 2014, 11:45 AM EST
Goran Dragic is playing nearly 35 minutes a night for the Suns and would like to rest this summer, but that means letting down his national team.
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Mar 24, 2014, 10:18 AM EST
I can't see how these next two years could go wrong for the Lakers.
Jeff Green on criticism of his inconsistency: 'I don't give a (expletive). It don't bother me'
Mar 21, 2014, 9:45 AM EST
Then he won't mind this post.
Report: Steve Nash to return to Lakers lineup Friday vs. Wizards
Mar 20, 2014, 11:26 PM EST
Steve Nash has played just 10 games for the Lakers this season as the nerve root issue that bothered him last season has limited him A couple weeks ago Mike D'Antoni said he didn't expect Nash to be back this season. He was wrong. At least according to a report from Adrian Wojnarowski of Yahoo…
League "addresses issue" to make sure Phil Jackson/Jeanie Buss relationship not conflict of interest
Mar 20, 2014, 3:15 PM EST
Lucky Jeanie and Phil get to have the NBA's lawyers help define the parameters of their relationship.
Wednesday NBA grades: Love, Rubio play like they should stay together
Mar 20, 2014, 3:29 AM EST
Ricky Rubio and Kevin Love work well together lifting Timberwolves past Mavericks. Also, Carmelo Anthony and the Knicks just keep on rolling.
Dwight Howard likely out for Rockets Thursday due to ankle injury
Mar 19, 2014, 3:38 PM EST
Dwight Howard has been healthy this season, and with that played like the guy the Lakers thought they were getting a year ago. Houston has looked good and improving with him in the paint. But he was out Monday night against Utah with an ankle strain suffered against Miami on Sunday. Now he is going…
Joakim Noah on Mike Dunleavy: 'He's finally giving Duke some credibility'
Mar 14, 2014, 11:00 AM EST
In ESPN's Fab Five documentary, Jalen Rose discussed how he felt about Duke while playing at Michigan. Rose: I hated Duke, and I hated everything I felt Duke stood for. Schools like Duke didn't recruit players like me. I felt like they only recruited black players that were Uncle Toms. To many, that's still the…
Thursday And-1 Links: An agent is unhappy with the players union. Shocking.
Mar 13, 2014, 6:06 PM EST
Here is our regular look around the NBA — links to stories worth reading and notes to check out (stuff that did not get its own post here at PBT) — done in bullet point form. Because bloggers love bullet points. • One of the things that got people buzzing today was agent Jeff Schwartz…
Kobe expects to be old self again next season, expects Lakers' front office to fix team fast
Mar 12, 2014, 5:08 PM EST
Kobe Bryant is frustrated — with his recovery, with the Lakers losing, with Lakers management. And he talks about it all.
Tuesday And-1 Links: Does Pete Carroll know something about Phil Jackson to Knicks?
Mar 11, 2014, 6:07 PM EST
Here is our regular look around the NBA — links to stories worth reading and notes to check out (stuff that did not get its own post here at PBT) — done in bullet point form. Because bloggers love bullet points more than Bobby Flay loves chili peppers…. • Seattle Seahawks coach Pete Carroll tweeted…
Kevin Love sets Minnesota Timberwolves' single-season 3-pointer record
Mar 10, 2014, 10:36 AM EST
Who held the record previously? Anyone? Bueller? Bueller?
Report: Cavaliers privately believe it's not too late to lure LeBron back to Cleveland
Mar 9, 2014, 12:30 PM EST
There's a fine line between hope and denial.
Is Carmelo Anthony's smart play to opt in and play out contract with Knicks?
Mar 7, 2014, 5:46 PM EST
According to every reliable source, Carmelo Anthony is going to opt out of the final year of his contract this season and look either to re-sign a five-year deal with the Knicks or move on to another team to be part of a contender. If Anthony wants to jump ship and go somewhere like oft-mentioned…
Kevin Love's response to Tyson Chandler is "(expletive) him." But don't think this is a feud.
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Wen-Han Cheng and Wen-Yu Ho contributed equally to this work.
Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation
Article first published online: 1 OCT 2013
DOI: 10.1111/bph.12317
© 2013 The British Pharmacological Society
Additional Information
How to Cite
Cheng, W.-H., Ho, W.-Y., Chang, C.-F., Lu, P.-J., Cheng, P.-W., Yeh, T.-C., Hong, L.-Z., Sun, G.-C., Hsiao, M. and Tseng, C.-J. (2013), Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation. British Journal of Pharmacology, 170: 847–858. doi: 10.1111/bph.12317
Publication History
- Issue published online: 1 OCT 2013
- Article first published online: 1 OCT 2013
- Accepted manuscript online: 25 JUL 2013 05:38AM EST
- Manuscript Accepted: 21 JUL 2013
- Manuscript Revised: 8 JUL 2013
- Manuscript Received: 8 FEB 2013
Funded by
- National Science Council. Grant Numbers: NSC100-2321-B-075B-002, NSC 101-2320-B-075B-002-MY3
- Kaohsiung Veterans General Hospital. Grant Number: VGHKS101-024
- Kaohsiung Medical University Hospital, Kaohsiung Medical University
- statins;
- nucleus tractus solitarii;
- nitric oxide;
- Ras;
- hypertension;
- isoprenylation
Background and Purpose
Clinical studies indicate that statins have a BP-lowering effect in hypercholesterolemic individuals with hypertension. Specifically, statins modulate BP through the up-regulation of endothelial NOS (eNOS) activation in the brain. However, the signalling mechanisms through which statins enhance eNOS activation remain unclear. Therefore, we examined the possible signalling pathways involved in statin-mediated BP regulation in the nucleus tractus solitarii (NTS).
Experimental Approach
To investigate the involvement of Ras and other signalling pathways in simvastatin-induced effects on BP, BP and renal sympathetic nerve activity (RSNA) were determined in spontaneously hypertensive rats (SHRs) before and after i.c.v. administration of simvastatin in the absence and presence of a Ras-specific inhibitor (farnesyl thiosalicylic acid, FTS), a geranylgeranyltransferase inhibitor (GGTI-2133), a PI3K inhibitor (LY294002) or a MAPK-ERK kinase (MEK) inhibitor (PD98059).
Key Results
FTS significantly attenuated the decrease in BP and increased NO evoked by simvastatin and reversed the decrease in basal RSNA induced by simvastatin. Immunoblotting and pharmacological studies showed that inhibition of Ras activity by FTS significantly abolished simvastatin-induced phosphorylation of ERK1/2, ribosomal protein S6 kinase (RSK), Akt and decreased eNOS phosphorylation. Likewise, administration of Akt and ERK1/2 signalling inhibitors, LY294002 and PD98059, attenuated the reduction in BP evoked by simvastatin. Furthermore, i.c.v. simvastatin decreased Rac1 activation and the number of ROS-positive cells in the NTS.
Conclusions and Implications
Simvastatin modulates central BP control in the NTS of SHRs by increasing Ras-mediated activation of the PI3K-Akt and ERK1/2-RSK signalling pathways, which then up-regulates eNOS activation.


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I grew up in Luton, which may not sound like a hotbed of multiculturalism but our personal corner of it always was – our family friends included Chinese, Jewish, Indians, Irish, Malaysians, Scottish, Sri Lankans amongst others. When it came to New Year, we celebrated according to both the Gregorian and traditional Chinese lunar calendars. [Read More…]
Kintan Restaurant | Yakiniku in LondonPete and really loved yakiniku dining during our two visits to Japan; I have written previously about our yakiniku experiences, along with the history of yakiniku. Considered a Korean import, the Japanese version is no longer an exact copycat of its Korean inspiration, not least in the range of meat cuts and marinades and the [Read More…] |
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Old Tom & English | A Members Club Without The MembershipOld Tom & English is not a members club but it feels like one. By that I don't mean stuffy, exclusive or expensive; rather it's a hidden gem, a welcoming space that calls forth a surprising sense of belonging. Its only frontage onto Wardour Street is an impressive but subtly labelled blue door behind which [Read More…] |
Recipe | Cider-Braised Pheasant with Shallots, Apples & ThymeIn my recent post about The Wild Meat Company's pheasant and partridge, I mentioned the first recipe we made on receipt of my big box of game birds. A twitter friend kindly shared her recipe for pheasant, and I filled in the details by thinking about other one pot braises I've cooked in the past. [Read More…] |
Microwave Magic | Why I Love My MicrowaveA lot of foodies scorn microwaves. They proudly announce that they don't, and never would, have one in their kitchen and I can't help but wonder if they imagine all those who have one subsist on microwave ready meals and reheated takeaways. I always feel a little sorry for them, honestly; their conviction that real [Read More…] |
A Visit to Vilnius | Lithuania's Capital CityJust before Christmas I was invited on a trip to visit Vilnius, Lithuania. As a country I've long wanted to visit, and with the added allure of December Christmas markets, I didn't hesitate to accept. I spent a wonderful few days exploring the city (and nearby Trakai) with incredibly knowledgeable, not to mention helpful, patient [Read More…] |
WeShouldBSFIC Round Up | ChocolateThis month's Bloggers Scream for Ice Cream was a joint challenge hosted by me and Choclette – BSFIC meets We Should Cocoa. We asked you to give us your chocolatey frozen treats and you obliged! Image via Big Spud, provided by Waitrose First up is this rather impressive Chocolate Passionfruit Baked Alaska from Gary at [Read More…] |
Rich, Dense & Dark Power Blender Chocolate Ice Cream | Perfect for Ice LolliesMy initial plan, when Choclette and I set our joint #WeShouldBSFIC challenge for January, was an ice cream sandwich. I wanted to make chewy chocolate chip cookies and sandwich white chocolate vanilla ice cream between them. But every time I started scribbling potential recipe notes, my thoughts turned instead to a chocolate ice cream recipe [Read More…] |
Meet The Blogger | Fiona BeckettFor many of us who blog, our blogs were our first foray into writing for a (potential) audience. Some were simply looking for a way to record their efforts (in the arenas of food, craft, poetry, DIY…) for future reference; some wanted a way to share an aspect of their lives with real life friends [Read More…] |


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בֵּין הַזְמַנִים
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By RUTHIE BLUM LEIBOWITZ \
02/22/2007 11:13
sir martin gilbert 88 29. (photo credit:Ariel Jerozolimski)
'This isn't the time of the Israelite prophets, when disaster struck in spite of their warnings, because the people didn't wake up. I think Europe has woken up' 'A seed won't germinate on infertile soil," says acclaimed British-Jewish historian Sir Martin Gilbert about the ease with which anti-Semitic sentiment seems to be spreading. He then quotes a passage from a letter written to Winston Churchill by a concerned colleague who refers to the "hereditary antipathy against the Jewish race." This passage appears in his upcoming book, Churchill and the Jews - the latest of several dozen major works, among them: The Holocaust: A History of the Jews of Europe During the Second World War; Churchill: A Life; The First World War; The Second World War; A Comprehensive History of Israel; and A History of the Twentieth Century. A regular visitor to Israel ("I try to come two or three times a year"), Churchill's official biographer - who just turned 70 - is here this time to attend Jerusalem's annual International Book Fair, where he delivered a talk Wednesday on "What Jews can learn from history." What, indeed, can anyone learn from history, when it appears to repeat itself in such full force - or at least in new forms, like that of the threat to Western civilization being posed by the current "barbarism" of radical Islam and its apologists? The answer, it turns out, is at once utterly simple and completely complex. On the one hand, asserts Sir Martin over breakfast at the King David Hotel, "Each nation has to know what it stands for... The weakness in many [Western] countries is the lack of clarity about the bedrock of their existence. And it is that bedrock which has to be defended." On the other hand, he insists, nothing is at it appears while it is going on. "What you see when you [examine archives opened only 30 years after an event] is that the people you imagined had been strong were weak; the people you thought weak were strong; and things you thought couldn't possibly be taking place were taking place." Hmmm. If so, one can only wait with anticipation to see whether Sir Martin will take up the offer - which he says he's "mulling" - to write a biography of former prime minister Ariel Sharon. Would you assess the current discourse on Israel as anti-Semitic? Anti-Semitism certainly plays a major part. People don't like Jews. It's legitimate to dislike people. But anti-Semitism is liking Jews even less than is permissible in sane discourse. Do you think that criticism of Israel is a way of using permissible discourse to express dislike of Jews? When one goes to debates, such as [London Mayor Ken] Livingstone's [event last month, titled "A World Civilization or a Clash of Civilizations?" - at which he debated Middle East Forum director Daniel Pipes], the difference between legitimate criticism, based on rational arguments, and anti-Semitic criticism, not based on answerable facts, but rather on nonsense, becomes clear quite quickly. What do you mean by "nonsense"? The theme of the Livingstone event was multiculturalism. Its subtext was that the only intolerance one ever finds in London is that against Muslims. Livingstone spoke very mellifluously. The only time he began to rant was when he was talking about Israel. The point he made was that Israel had no legitimacy - he even called its existence a "travesty." When, in response, somebody asked him about the November 1947 UN vote for a Jewish state, he said: "Ah, the United Nations then was dominated and controlled by the United States, which didn't want the 100,000 Jewish survivors of the Holocaust to go to America, so it voted to establish the State of Israel to keep the Jews out." Is there a connection between anti-Americanism and anti-Zionism? At the moment, anti-Americanism is very strong in Western Europe and in Britain. America's perceived unconditional support for Israel - which is one of these things upon which an incredible amount of myth is built - is a black mark. Then there is the belief of Jewish dominance over America, an example of which can be seen in the recent report about AIPAC and in former US president Jimmy Carter's book. How much of this is mere "nonsense," accepted by ignorant people who don't know the facts, and how much an intellectual tool anti-Semites are happy to use as justification? I think it is more the latter. A seed won't germinate on infertile soil. I just finished a book, which is being published in June, on Churchill's relationship with the Jews and the Zionists. On one occasion when Churchill was arguing the case for a Jewish state, one of his conservative colleagues wrote him: "You don't understand that you are going to stir up the hereditary antipathy against the Jewish race." What would Churchill have said about the Israeli government's response to attack over the last few years? He always quoted the French saying, "Cet animal est mechant." This animal is dangerous; when you attack him, he defends himself. A nation has to defend itself. In the 1930s, when the whole fabric of Western civilization was under attack by Nazism - even before a single shot had been fired, or a single German soldier had crossed a border - Churchill said, "We're under attack and we have to defend ourselves; we have to know what it is we stand for." Do you see a parallel between Churchill's attitude and that of George Bush after 9/11? The war against the Taliban and al-Qaida was an example of defending yourself, even when your borders weren't being breached by armies. Is there not a greater problem today than during World War II identifying the enemy? The real problem is that each nation has to know what it stands for - what ideology it adheres to. The weakness in many [Western] countries is the lack of clarity about the bedrock of their existence. And it is that bedrock which has to be defended. More than borders, because borders are less and less under attack. Prime Minister Tony Blair has touted British values that are central to our society: democracy, rule of law, free speech. Not based on hatred. When you have, within that society, people for whom hatred seems to be a dominant force, you have to say to them, as cruel as it may sound: "If you come here to be part of our society, and don't like our basic norms, please go find a society more amenable to your own way of life." Why is the concept of freedom so elusive, particularly among the people who most enjoy it? The hardest thing to enjoy is freedom. One takes it for granted when it's not something he's had to struggle for. In Israel, there is a whole generation who had to struggle for the very existence of the state. Britain has been in existence for hundreds of years; Israel is merely 59. So, Israelis may be more attuned to what it is they are struggling for and seeking to maintain. In England, Western Europe and the United States, that's much less true. In Eastern Europe, on the other hand, it's only been 15 years since they've thrown off communism - so there, it is a bit different. Still, I was recently talking to a Pole in her mid-20s, who has no memory of the communist period. So, there's already a new generation in Eastern Europe for whom the struggle against communism and to establish independent national identities is not part of their memory. They, too, have to be reminded - whether by their parents or by reading - that "this is what we stand for, and that is what we struggled for; and now we have it." How is it, then, that the younger generation in the West, which doesn't know what it's like to fight for freedom, nevertheless talks a lot about freedom for women, gays and minorities? I wouldn't say this is universal, and depends on the youth themselves: their upbringing, environment, organizations with which they are affiliated. Education plays a major part. But in the West today, liberal education educates to liberalism. That may be the case, but there are also trends in education. At his debate, Livingstone posited multiculturalism as a universal good and the status quo indicating that the only conflict in the world was between multiculturalism and its enemies. Daniel Pipes said something very different: that the conflict in the world is between culture and barbarism - that there is civilized behavior, and there is also a barbaric instinct. This barbaric instinct has to be recognized and understood. It may be much harder to see, because it's not a very comforting thought. Why isn't it comforting? Because it involves struggle. Danger. Having to respond to danger. The other day, the British police raided one of the major mosques in London, much to the indignation of the Muslim community, which said it was a violation of its freedom. The police raided that mosque, in fact, in order to enter its adjacent bookshop and remove inflammatory material - the sort that's on the barbarism side of Daniel Pipes's equation. The debate among liberal people about whether it's right to break into a mosque's premises or a bookshop is clear: Wait a minute - a bookshop! That's freedom of speech. After all, Hitler burned books outside the Opera House in 1933. That's what makes this all very difficult to conceptualize. Are there really circumstances under which we have to seize or make certain books unavailable? The answer, in my view, is yes. Because this barbarism is a reality; it's not just some enemy facing you with a gun. It is an ideological and surreptitious enemy that works through the educational system of the adversary. Speaking of books, let's talk about the Koran. There's is an ongoing debate about whether the holy book of Islam is inherently violent or has been hijacked by extremists. What is your view? That it's in the interpretation. All religions have had their zealots interpret their holy texts in a way that has led to bloodshed and war. For many hundreds of years, the New Testament led to the most terrifying violence. But then, new interpretations came forward, and continued to come forward, so now we have a situation in which the Christian theologians and the Catholic Church have turned their back on anything in the scriptures that implies the Jews were responsible for the murder of Jesus. Islam has always had extremist movements. In the Middle Ages, for example. Now we have Wahhabism and its various derivatives. This is a phase we're in. In the current crisis over the Mughrabi Gate ramp - something with which I've been familiar over the last 35 years in my work on Jerusalem - the head of the Arab League called [the renovations] an attempt to create a synagogue in the area and an insult to Muslims that has to be fought. It was equally open to him to say that it is an absurd storm in a teacup - that this thing is 60 meters from the wall; not slated for a synagogue, but actually just a dangerous structure. In other words, in the end, it's up to each individual - in this case Muslim leader - to decide how he wants to interpret and present his scriptures. But doesn't this bring us to the connection between religion and politics? If you use the goings-on in the Palestinian Authority right now as an example, you can see the way religion is used as a tool to rally the people around a common enemy. If so, it would not serve any leader's interest to interpret the texts differently. Nor would it have served the purposes of the head of the Arab League you mentioned to have called the Mughrabi ramp crisis an "absurd storm in a teacup." Religious leaders have a tremendous responsibility not to distort their religious texts. My wife and I happened to be walking in the Old City on Friday just after lunch, and we heard the imam of the mosque blasting out hatred. Well, this is certainly political, in the sense that it has a political agenda. But it is based on religion. There is a phenomenon in the current Muslim world, which has arisen before, but which has rearisen in a bizarre form - thanks, mainly to Osama bin Laden: the restoration of the caliphate. This is a combined political-religious force which Islam created in the past, but which most modern societies long ago turned their back on. The idea that anyone - least of all young Muslims in Britain - should dream of restoring a powerful medieval tool of Islamic conquest and rule is incredible. Historian Bernard Lewis refers to Western Europe's capitulation; Eurabia author Bat Yeor warns of its demographic Islamization. Is barbarism indeed winning? I'm a great believer in people's waking up. Sometimes, they wake up rather late. Britain in 1938 was capitulating; in 1939 it woke up - much, incidentally, to Hitler's surprise. When he was told the British were now going to actually stand up against him, he said, "Oh, no. I saw these worms at Munich, and they're not going to do anything now that I'm about to attack Poland." But he was wrong. I think that's true now of Britain, as well. Britain has woken up. But what about the demography problem? I've read Bat Yeor's book. I know her and have a great respect for her sense of anguish. She has studied the way in which the European Parliament and European institutions have become infiltrated by thoughts and legislation which are essentially seeking to appease fundamentalist Islamic activity - the ultimate dominance of the caliphate and Sharia law in Europe. But we're a long, long way from that. Are you saying that the presentation of her findings is too alarmist? No. I'm saying that her book - which is 100 percent accurate - is an alarm call that will ultimately prevent what she's warning about from taking place. The same applies to Bernard Lewis. Because he is the greatest mind of our time in this whole area, people will take his warnings seriously. This isn't the time of the Israelite prophets, when disaster struck in spite of their warnings, because the people didn't wake up. I think Europe has woken up. If so, will Europeans view the United States more positively - as an ally in the struggle against barbarism? The relationship between Europe and the United States has always been complicated. Every sane British person knows that we only won the two world wars of the 20th century because of American intervention and commitment. But there are levels of grievance, the first being that this intervention and commitment came rather late, which caused a lot of unnecessary suffering. The greater level of grievance comes precisely from the sense that we were dependent on the US during those wars. Anti-Americanism has its surges and probably always will. As a school boy after World War II - when the Marshall Plan was enabling us finally to have fresh eggs instead of powdered ones - I remember people reducing American culture to Coca-Cola and Hollywood. It's the jealousy of smaller nations and lesser minds. Still, there are many Britons - myself included - who regard America's contribution to both world wars, and massively to the Marshall Plan after World War II, as the defining contribution in the survival of Western values and democracy. Today, the British government, at some considerable loss of popularity, stood by the US in Afghanistan and Iraq. More importantly, it doesn't belittle American civilization. As for Europe, if, on a deeper level, it feels itself in danger from the Islamist threat, there will be a greater understanding of the American position. Ironically, the United States is not at the moment threatened in the way that Europe is. There isn't a great extremist Islamist movement within the US. According to American Center for Democracy director Rachel Ehrenfeld, there is a wider network in the US than is immediately apparent. It may become so five or 10 years from now. But right now, Americans do not perceive a threat from Islamic fundamentalism from within. Americans not perceiving such a threat could land Hillary Clinton in the White House. Perhaps that'll be a good thing. If she becomes president and the threat materializes, she will feel all the more cheated and betrayed, and will become a tough, feisty opponent. Name another leader who felt betrayed and as a result became a tough opponent. Neville Chamberlain. He had wanted to make concessions to Hitler because he believed there was no ultimate quarrel between Britain and Germany. When the war came, he became the toughest supporter of drastic action against Germany. How much of a role does Iran play in this discussion? Iran, by its own actions, has alerted Europe, and the European Union is taking an increasingly strong stand. People no longer dismiss extremist statements as mere verbiage. This is one lesson which has been learned from history. When Hitler said in 1939, "The war will not end with the Bolshevization of Europe, but with the destruction of the Jews," people said, "Well, that's just a way of speaking." When Ahmadinejad said he wanted to wipe Israel off the map, people sat up and took notice. If what you say about alarm bells and learning from history is true, how do you explain that in Israel there is still a view that appeasing the Palestinians is a better course than defeating them, or that siding with Fatah is a way of weakening Hamas? As a historian, I'm very cautious about anyone's claiming to know what any government is doing at the present time. Israel elected this government. It's an amalgam - one might say a sludgy amalgam - of political forces. Though some of its leaders appear to have minor blemishes, they were chosen by the electoral process. And we do not really know what they're actually doing in their conclaves. As we're sitting here in the lobby of the King David Hotel, we don't know whether, in another room in the hotel, some Israeli official is sitting with someone from Hamas. Just as in the old days, when you couldn't sit with the PLO, meetings were held with them. If the leaders have decided that Abu Mazen [PA Chairman Mahmoud Abbas] is the one they want to support, let's say they have a reason for it, though it may be a reason we don't know. We don't know what the actual relationship between the Israeli leaders and the Fatah leaders is. Certainly, if you read the newspapers, the situation looks bizarre. Commenting on the Mughrabi Gate ramp, Abu Mazen made an extremely hostile and uncompromising statement from Mecca. It certainly didn't smack either of statesmanship or of trying to find a peaceful way forward. I study archives as soon as they are open - normally 30 years after an event; sometimes a bit less. What you see when you do this is that the people you imagined had been strong were weak; the people you thought weak were strong; and things you thought couldn't possibly be taking place were taking place. If 30 years later, you discover that nothing is the way you'd perceived it at the time, isn't it ridiculous to form any opinions while you're living through something? [He laughs] Well, you have to form opinions. One of the bases of democratic government is that each elected leader promises open government, no secret deals, etc. And it may be that before coming to power, candidates think that's actually how they're going to behave. But they can't. The very nature of international relations - even domestic politics, to some extent - is that there are so many factors a prime minister is confronted with in the first dossier he opens that are unknown to him and the public. So, right at the outset he finds himself having to withhold information. But you can't say to the public, "Look, things don't seem right. You heard a bit of shooting here, and there's bit of trouble over there, but it's not going to be for another 30 years before you'll know what we're doing." You have to hope your governments will be more open rather than less, but you shouldn't be under any illusions that what you're told is 100% of the truth. It's an approximation to the truth, and you hope it's not lies. What was your most surprising archival revelation - one that completely contradicted your previous assumptions? I wouldn't have gone on writing history if it hadn't been for the fact that nothing is what it seems when you go into the archives. But the most interesting thing, from an Israeli perspective, is about Lawrence of Arabia. The great Arabist, right? The man who supported the Arabs, and who pushed for Arab nationhood in the 1920s. He's always pictured wearing Arab robes. What is so astonishing - which you'll see in my next book, Churchill and the Jews - is that he was a serious Zionist. He believed that the only hope for the Arabs of Palestine and the rest of the region was Jewish statehood - that if the Jews had a state here, they would provide the modernity, the "leaven," as he put it, with which to enable the Arabs to move into the 20th century. He had a sort of contempt for the Arabs, actually. He felt that only with a Jewish presence and state would the Arabs ever make anything of themselves. And, by a Jewish state, he meant a Jewish state from the Mediterranean shore to the River Jordan - something [he says, smiling] which will never come to pass.
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