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Leptin | |||||||||||||
PDB rendering based on 1ax8. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | LEP ; LEPD; OB; OBS | ||||||||||||
External IDs | OMIM: 164160 MGI: 104663 HomoloGene: 193 GeneCards: LEP Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 3952 | 16846 | |||||||||||
Ensembl | ENSG00000174697 | ENSMUSG00000059201 | |||||||||||
UniProt | P41159 | P41160 | |||||||||||
RefSeq (mRNA) | NM_000230 | NM_008493 | |||||||||||
RefSeq (protein) | NP_000221 | NP_032519 | |||||||||||
Location (UCSC) | Chr 7: 127.88 – 127.9 Mb | Chr 6: 29.06 – 29.07 Mb | |||||||||||
PubMed search | [1] | [2] | |||||||||||
Leptin | |||||||||
Structure of the obese protein leptin-E100.[1] | |||||||||
Identifiers | |||||||||
Symbol | Leptin | ||||||||
Pfam | PF02024 | ||||||||
Pfam clan | CL0053 | ||||||||
InterPro | IPR000065 | ||||||||
SCOP | 1ax8 | ||||||||
SUPERFAMILY | 1ax8 | ||||||||
Leptin (from Greek λεπτός leptos, "thin"), the "satiety hormone", is a hormone made by fat cells which regulates the amount of fat stored in the body. It does this by adjusting both the sensation of hunger, and adjusting energy expenditures. Hunger is inhibited (satiety) when the amount of fat stored reaches a certain level. Leptin is then secreted and circulates through the body, eventually activating leptin receptors in the arcuate nucleus of the hypothalamus. Energy expenditure is increased both by the signal to the brain, and directly via leptin receptors on peripheral targets. The effect of leptin is opposite to that of ghrelin, the "hunger hormone". Ghrelin receptors are on the same brain cells as leptin receptors, so these cells receive competing satiety and hunger signals.[2] Leptin and ghrelin, along with many other hormones, participate in the complex process of energy homeostasis.
Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its multiple sites of synthesis other than fat cells, and the multiple cell types beside hypothalamic cells which have leptin receptors. Many of these additional functions are yet to be defined.[3][4][5][6][7][8]
The existence of a hormone regulating hunger and energy expenditure was hypothesized based on studies of mutant obese mice that arose at random within a mouse colony at the Jackson Laboratory in 1950. Mice homozygous for the ob mutation (ob/ob) ate voraciously and were massively obese.[9] In the 1960s, a second mutation causing obesity and a similar phenotype was identified by Douglas Coleman, also at the Jackson Laboratory, and was named diabetes (db), as both ob/ob and db/db were obese.[10][11][12] Rudolph Leibel and Jeffrey M. Friedman reported the mapping of the ob gene in 1990.[13][14][15] Consistent with Coleman's and Leibel's hypothesis, several subsequent studies from Leibel's and Friedman's labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice.[3][4][5][6] In 1994, with the ob gene isolated, Friedman reported the discovery of the gene.[12] At the suggestion of Roger Guillemin, Friedman named this new hormone "leptin" from the Greek lepto meaning thin.[3][16] Leptin was the first fat cell-derived hormone to be discovered. Subsequent studies confirmed that the db gene encodes the leptin receptor and that it is expressed in the hypothalamus, a region of the brain known to regulate the sensation of hunger and body weight.[17][18][19][20]
Coleman and Friedman have been awarded numerous prizes acknowledging their roles in discovery of leptin, including the Gairdner Foundation International Award (2005),[21] the Shaw Prize (2009),[22] the Lasker Award,[23] the BBVA Prize[24] and the King Faisal International Prize,[25] Leibel has not received the same level of recognition from the discovery because he was omitted as a co-author of a scientific paper published by Friedman that reported the discovery of the gene. The various theories surrounding Friedman's omission of Leibel and others as co-authors of this paper have been presented in a number of publications, including Ellen Ruppel Shell's 2002 book The Hungry Gene.[26][27]
The discovery of leptin is also documented in a series of books including Fat: Fighting the Obesity Epidemic by Robert Pool,[28] The Hungry Gene by Ellen Ruppel Shell, and Rethinking Thin: The New Science of Weight Loss and the Myths and Realities of Dieting by Gina Kolata.[29][30] Fat: Fighting the Obesity Epidemic and Rethinking Thin: The New Science of Weight Loss and the Myths and Realities of Dieting review the work in the Friedman laboratory that led to the cloning of the ob gene, while The Hungry Gene draws attention to the contributions of Leibel.
The Ob(Lep) gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.[31] Human leptin is a 16 kDa protein of 167 amino acids.
Leptin is produced primarily in the adipocytes of white adipose tissue. It is also produced by brown adipose tissue, placenta (syncytiotrophoblasts), ovaries, skeletal muscle, stomach (the lower part of the fundic glands), mammary epithelial cells, bone marrow, pituitary, liver,[32]gastric chief cells and P/D1 cells.[33]
Leptin circulates in blood in free form and bound to proteins.[34] Leptin levels vary exponentially, not linearly, with fat mass.[35][36][full citation needed] Leptin levels in blood are higher between midnight and early morning, perhaps suppressing appetite during the night.[37] The diurnal rhythm of blood leptin levels can be modified by meal-timing.[38]
In humans, many instances are seen where Leptin dissociates from the strict role of communicating nutritional status between body and brain and no longer correlates with body fat levels:
It is important to recognize that the terms central, primary, and direct are not used interchangeably: Central vs peripheral refers to hypothalamic vs non-hypothalamic location of action of leptin; direct vs indirect refers to whether there is no intermediary, or there is an intermediary in the mode of action of leptin; and primary vs secondary is an arbitrary description of a particular function of leptin.[56]
Leptin acts on receptors in the hypothalamus, where it inhibits hunger by
This appetite inhibition is long-term, in contrast to the rapid inhibition of hunger by cholecystokinin (CCK) and the slower suppression of hunger between meals mediated by PYY3-36. The absence of leptin (or its receptor) leads to uncontrolled hunger and resulting obesity. Fasting or following a very-low-calorie diet lowers leptin levels.[57][58][59][60] Leptin levels change more when food intake decreases than when it increases.[61] The dynamics of leptin due to an acute change in energy balance may be related to appetite and eventually to food intake rather than fat stores.[62][63]
Leptin binds to neuropeptide Y (NPY) neurons in the arcuate nucleus in such a way as to decrease the activity of these neurons. Leptin signals to the hypothalamus which produces a feeling of satiety. Moreover, leptin signals may make it easier for people to resist the temptation of foods high in calories.[65]
Leptin receptor activation inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP), and activates α-melanocyte-stimulating hormone (α-MSH). The NPY neurons are a key element in the regulation of hunger; small doses of NPY injected into the brains of experimental animals stimulates feeding, while selective destruction of the NPY neurons in mice causes them to become anorexic. Conversely, α-MSH is an important mediator of satiety, and differences in the gene for the α-MSH receptor are linked to obesity in humans.
Leptin interacts with six types of receptors (Ob-Ra–Ob-Rf, or LepRa-LepRf), which in turn are encoded by a single gene, LEPR.[66] Ob-Rb is the only receptor isoform that can signal intracellularly via the Jak-Stat and MAPK signal transduction pathways,[67] and is present in hypothalamic nuclei.[68]
Leptin is generally thought to enter the brain at the choroid plexus, where the intense expression of a form of leptin receptor molecule could act as a transport mechanism.[69]
Once leptin has bound to the Ob-Rb receptor, it activates the stat3, which is phosphorylated and travels to the nucleus to effect changes in gene expression, One of the main effects being the down-regulation of the expression of endocannabinoids, responsible for increasing hunger.[70] In response to leptin, receptor neurons have been shown to remodel themselves, changing the number and types of synapses that fire onto them.
Increased levels of melatonin causes a downregulation of leptin.[71] However melatonin also appears to increase leptin levels in the presence of insulin, therefore causing a decrease in appetite during sleeping.[72] Partial sleep deprivation has also been associated with decreased leptin levels.[73]
Mice with type 1 diabetes treated with leptin or leptin plus insulin, compared to insulin alone had better metabolic profiles: blood sugar did not fluctuate as much; cholesterol levels decreased; less body fat formed.[74]
Non-hypothalamic targets of leptin are referred to as peripheral targets, in contrast to the hypothalamic target which is the central target. Leptin receptors are found on a wide range of cell types. There is a different relative importance of central and peripheral leptin interactions under different physiologic states, and variations between species.[32] In the periphery leptin is a modulator of energy expenditure, modulator between fetal and maternal metabolism, permissive factor in puberty, activator of immune cells, activator of beta islet cells,and a growth factor. Further, it interacts with other hormones and energy regulators: insulin, glucagon, insulin-like growth factor, growth hormone, glucocorticoids, cytokines, and metabolites.[32]
The role of leptin/leptin receptors in modulation of T cell activity in immune system was shown in experimentation with mice. It modulates the immune response to atherosclerosis, of which obesity is a predisposing factor.[75]
Exogenous leptin can promote angiogenesis by increasing vascular endothelial growth factor levels.
Hyperleptinemia produced by infusion or adenoviral gene transfer decreases blood pressure in rats.[76][77]
Leptin microinjections into the nucleus of the solitary tract (NTS) have been shown to elicit sympathoexcitatory responses, and potentiate the cardiovascular responses to activation of the chemoreflex.[78]
In fetal lung, leptin is induced in the alveolar interstitial fibroblasts ("lipofibroblasts") by the action of PTHrP secreted by formative alveolar epithelium (endoderm) under moderate stretch. The leptin from the mesenchyme, in turn, acts back on the epithelium at the leptin receptor carried in the alveolar type II pneumocytes and induces surfactant expression, which is one of the main functions of these type II pneumocytes.[79]
In mice, and to a lesser extent in humans, leptin is required for male and female fertility. Ovulatory cycles in females are linked to energy balance (positive or negative depending on whether a female is losing or gaining weight) and energy flux (how much energy is consumed and expended) much more than energy status (fat levels). When energy balance is highly negative (meaning the woman is starving) or energy flux is very high (meaning the woman is exercising at extreme levels, but still consuming enough calories), the ovarian cycle stops and females stop menstruating. Only if a female has an extremely low body fat percentage does energy status affect menstruation. Leptin levels outside an ideal range can have a negative effect on egg quality and outcome during in vitro fertilization.[80] Leptin is involved in reproduction by stimulating gonadotropin-releasing hormone from the hypothalamus.[81]
The placenta produces leptin.[82] Leptin levels rise during pregnancy and fall after childbirth. Leptin is also expressed in fetal membranes and the uterine tissue. Uterine contractions are inhibited by leptin.[83] Leptin plays a role in hyperemesis gravidarum (severe morning sickness of pregnancy),[84] in polycystic ovary syndrome[85] and hypothalamic leptin is implicated in bone growth in mice.[86]
Immunoreactive leptin has been found in human breast milk; and leptin from mother's milk has been found in the blood of suckling infant animals.[87]
Leptin along with kisspeptin controls the onset of puberty.[88] High levels of leptin, as usually observed in obese females, can trigger neuroendocrine cascade resulting in early menarche.[89] This may eventually lead to shorter stature as oestrogen secretion starts during menarche and causes early closure of epiphyses.
Leptin's ability to regulate bone mass was first recognized in 2000.[90] Leptin can affect bone metabolism via direct signalling from the brain. Leptin decreases cancellous bone, but increases cortical bone. This "cortical-cancellous dichotomy" may represent a mechanism for enlarging bone size, and thus bone resistance, to cope with increased body weight.[91]
Bone metabolism can be regulated by central sympathetic outflow, since sympathetic pathways innervate bone tissue.[92] A number of brain-signalling molecules (neuropeptides and neurotransmitters) have been found in bone, including adrenaline, noradrenaline, serotonin, calcitonin gene-related peptide, vasoactive intestinal peptide and neuropeptide Y.[92][93] Leptin binds to its receptors in the hypothalamus, where it acts through the sympathetic nervous system to regulate bone metabolism.[94] Leptin may also act directly on bone metabolism via a balance between energy intake and the IGF-I pathway.[91][95] There is a potential for treatment of diseases of bone formation - such as impaired fracture healing - with leptin.[96]
Leptin receptors are expressed not only in the hypothalamus but also in other brain regions, particularly in the hippocampus. Thus some leptin receptors in the brain are classified as central (hypothalamic) and some as peripheral (non-hypothalamic).
Factors that acutely affect leptin levels are also factors that influence other markers of inflammation, e.g., testosterone, sleep, emotional stress, caloric restriction, and body fat levels. While it is well-established that leptin is involved in the regulation of the inflammatory response,[103][104][105] it has been further theorized that leptin's role as an inflammatory marker is to respond specifically to adipose-derived inflammatory cytokines.
In terms of both structure and function, leptin resembles IL-6 and is a member of the cytokine superfamily.[1][104][106] Circulating leptin seems to affect the HPA axis, suggesting a role for leptin in stress response.[107] Elevated leptin concentrations are associated with elevated white blood cell counts in both men and women.[108]
Similar to what is observed in chronic inflammation, chronically elevated leptin levels are associated with obesity, overeating, and inflammation-related diseases, including hypertension, metabolic syndrome, and cardiovascular disease. However, while leptin is associated with body fat mass, the size of individual fat cells, and the act of overeating, it is interesting that it is not affected by exercise (for comparison, IL-6 is released in response to muscular contractions). Thus, it is speculated that leptin responds specifically to adipose-derived inflammation.[109] Leptin is a pro-angiogenic, pro-inflammatory and mitogenic factor, the actions of which are reinforced through crosstalk with IL-1 family cytokines in cancer.[110]
Taken as such, increases in leptin levels (in response to caloric intake) function as an acute pro-inflammatory response mechanism to prevent excessive cellular stress induced by overeating. When high caloric intake overtaxes fat cells' ability to grow larger or increase in number in step with caloric intake, the ensuing stress response leads to inflammation at the cellular level and ectopic fat storage, i.e., the unhealthy storage of body fat within internal organs, arteries, and/or muscle. The insulin increase in response to the caloric load provokes a dose-dependent rise in leptin, an effect potentiated by high cortisol levels.[111] (This insulin-leptin relationship is notably similar to insulin's effect on the increase of IL-6 gene expression and secretion from preadipocytes in a time- and dose-dependent manner.)[112] Furthermore, plasma leptin concentrations have been observed to gradually increase when acipimox is administered to prevent lipolysis, concurrent hypocaloric dieting and weight loss notwithstanding.[113] Such findings appear to demonstrate high caloric loads in excess of fat cells' storage rate capacities lead to stress responses that induce an increase in leptin, which then operates as an adipose-derived inflammation stopgap signaling for the cessation of food intake so as to prevent adipose-derived inflammation from reaching elevated levels. This response may then protect against the harmful process of ectopic fat storage, which perhaps explains the connection between chronically elevated leptin levels and ectopic fat storage in obese individuals.[55]
Although leptin reduces appetite as a circulating signal, obese individuals generally exhibit a higher circulating concentration of leptin than normal weight individuals due to their higher percentage body fat.[8] These people show resistance to leptin, similar to resistance of insulin in type 2 diabetes, with the elevated levels failing to control hunger and modulate their weight. A number of explanations have been proposed to explain this. An important contributor to leptin resistance is changes to leptin receptor signalling, particularly in the arcuate nucleus. However, deficiency of, or major changes to, the leptin receptor itself are not thought to be a major cause. Other explanations suggested include changes to the way leptin crosses the blood brain barrier or alterations occurring during development.[114]
Studies on leptin cerebrospinal fluid (CSF) levels provide evidence for the reduction in leptin crossing the BBB and reaching obesity-relevant targets, such as the hypothalamus, in obese people[115] In humans it has been observed that the ratio of leptin in the blood compared to the CSF is lower in obese people than in people of a normal weight.[116] The reason for this may be high levels of triglycerides affecting the transport of leptin across the BBB or due to the leptin transporter becoming saturated.[115] Although deficits in the transfer of leptin from the plasma to the CSF is seen in obese people, they are still found to have 30% more leptin in their CSF than lean individuals.[116] These higher CSF levels fail to prevent their obesity. Since the amount and quality of leptin receptors in the hypothalamus appears to be normal in the majority of obese humans (as judged from leptin-mRNA studies),[117] it is likely that the leptin resistance in these individuals is due to a post leptin-receptor deficit, similar to the post-insulin receptor defect seen in type 2 diabetes.[118]
When leptin binds with the leptin receptor, it activates a number of pathways. Leptin resistance may be caused by defects in one or more part of this process, particularly the JAK/STAT pathway. Mice with a mutation in the leptin receptor gene which prevents the activation of STAT3 are obese and exhibit hyperphagia. The PI3K pathway may also be involved in leptin resistance, as has been demonstarated in mice by artificial blocking of PI3K signalling. The PI3K pathway is also activated by the insulin receptor and is therefore an important area where leptin and insulin act together as part of energy homeostasis. The insulin-pI3K pathway can cause POMC neurons to become insensitive to leptin through hyperpolarization.[119]
The consumption of a high fructose diet from birth has been associated with a reduction in leptin levels and reduced expression of leptin receptor mRNA in rats. Long-term consumption of fructose in rats has been shown to increase levels of triglycerides and trigger leptin and insulin resistance.[120][121] However, another study found that leptin resistance only developed in the presence of both high fructose and high fat levels in the diet. A third study found that high fructose levels reversed leptin resistance in rats given a high fat diet. The contradictory results mean that is uncertain if leptin resistance is caused by high levels of carbohydrates or fats, or if an increase or both is needed.[122]
Leptin is known to interact with amylin, a hormone involved in gastric emptying and creating a feeling of fullness. When both leptin and amylin were given to obese, leptin-resistant rats, sustained weight loss was seen. Due to its apparent ability to reverse leptin reisistance, amylin has been suggested as possible therapy for obesity.[123]
It has been suggested that the main role of leptin is to act as a starvation signal when levels are low, to help maintain fat stores for survival during times of starvation, rather than a satiety signal to prevent overeating. Leptin levels signal when an animal has enough stored energy to spend it in pursuits besides acquiring food.[119][124] This would mean that leptin resistance in obese people is a normal part of mammalian physiology and could possibly confer a survival advantage.[114] Leptin resistance (in combination with insulin resistance and weight gain) is seen in rats after they are given unlimited access to palatable, energy-dense foods.[125] This effect is reversed when the animals are put back on a low-energy diet.[126] This may also have an evolutionary advantage: allowing energy to be stored efficiently when food is plentiful would be advantageous in populations where food can frequently be scarce.[127]
A nonsense mutation in the leptin gene that results in a stop codon and lack of leptin production was first observed in mice in 1950. No homologous mutation has been found in humans. In the mouse gene, arginine-105 is encoded by CGA and only requires one nucleotide change to create the stop codon TGA. The corresponding amino acid in humans is encoded by the sequence CGG and would require two nucleotides to be changed in order to produce a stop codon, which is much less likely to happen.[7]
Leptin over-expression in adipose tissue has been observed in a number of individuals with morbid obesity. However, the association between leptin mutations and obesity in humans is less clear than in mice. A Human Genome Equivalent (HuGE) review of previous studies looking at the connection between genetic mutations affecting leptin regulation and obesity was published in 2004. As well as looking at a common polymorphism in the leptin gene (A19G; frequency 0.46), they also reviewed 3 mutations in the leptin receptor gene (Q223R, K109R and K656N) and 2 mutations in the PPARG gene (P12A and C161T). They found no association between any of the polymorphisms and obesity.[128]
A meta-analysis found no association between the common LEP-2548 G/A mutation and obesity in the overall results but did find a significant link between obesity and the GG phenotype in the American population.[129] A previous study has found a similar link between the GG phenotype and morbid obesity in Taiwanese aborigines.[130] The -2548A/G polymorphism has been associated with weight gain patients taking antipsychotics.[131][132][133] This polymorphism has also been linked with an increased risk of prostate cancer,[134] gestational diabetes[135] and osteoporosis.[136]
A recessive frameshift mutation resulting in a reduction of leptin has been observed in two consanguineous children with juvenile obesity. Other rare polymorphisms have been found but their association with obesity are not consistent. This may be due to the fact that obesity is a complex problem involving multiple genes as well as environmental influences.[128]
Dieters who lose weight experience a drop in levels of circulating leptin. This drop causes reversible decreases in thyroid activity, sympathetic tone, and energy expenditure in skeletal muscle, and increases in muscle efficiency and parasympathetic tone. The result is that a person who has lost weight has a lower basal metabolic rate than an individual at the same weight who has never lost weight; these changes are leptin-mediated, homeostatic responses meant to reduce energy expenditure and promote weight regain. Many of these changes are reversed by peripheral administration of recombinant leptin to restore pre-diet levels.[137]
A decline in levels of circulating leptin also changes brain activity in areas involved in the regulatory, emotional, and cognitive control of appetite that are reversed by administration of leptin.[137]
Leptin has not been approved for any therapeutic use.
An analog of human leptin, metreleptin (trade name Myalept), has been approved in Japan for metabolic disorders including lipodystrophy. In the United States it is approved as a treatment for complications of leptin deficiency, including diabetes and hypertriglyceridemia, in people with congenital generalized or acquired generalized lipodystrophy.[138][139]
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With machines set up in rows to encourage competition, many ordinary gyms cater to men's bodies and psychology, right down to the urinals that were "accidentally" installed in the women's locker room. At Curves, you'll move around a circuit of hydraulic resistance machines that have been designed to work with women's bodies to promote weight loss, protect against osteoporosis, and deal with arthritis. An experienced trainer is always nearby to help manage your machine maneuvering and your muscle making. Instead of fiddling with weight stacks and losing your momentum, the hydraulic machines use your body weight and fitness level to create resistance that matches your abilities, decreasing the risk of soreness or injury. Because traditional lift-and-lower motions create bulky muscles, each machine uses push-and-pull motions to create toned, lean muscles perfect for crushing a grapefruit without looking like you can.
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The grappling fighting style known as jujitsu first came to Brazil in 1914 stored in the hands and mind of Mitsuyo Maeda, a Japanese immigrant and master of the art. He only stayed a year, but it was enough time to plant the seeds for a new jujitsu academy in Brazil. One of the first students at that academy was Hélio Gracie.
Hélio absorbed the fighting style quickly, adapting many of the techniques to suit his small frame. He discovered methods of leverage that allowed him to execute joint locks, choke holds, and takedowns on much larger opponents, forming the core of his new Gracie jujitsu method. Ultimately, Hélio's son Royce brought the fighting style to America, famously winning UFC 1, 2, and 4 by defeating opponents many times his own size. Suddenly, Americans lined up to learn this newly unveiled Brazilian fighting style, demonstrating their eagerness by folding themselves inside a box and shipping themselves south.
Relson Gracie, Hélio's second oldest son, chose to be an ambassador of his family's fighting style. He was already teaching abroad when his little brother Royce skyrocketed Brazilian jujitsu to popularity. He founded his first school under the name Relson Gracie Jiu-Jitsu in Hawaii, and as the art became popular, he opened new branches of his academy all across the United States. Today, he visits more than 40 academies and associations, sharing his knowledge with thousands of students. In his absence, he leaves instructors whom he personally trained to oversee the education of aspiring fighters.

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11 because as high as heaven is above the earth, that's how large God's faithful love is for those who honor him. | 11 For as high as the heavens are above the earth, so great is his love for those who fear him; |
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Bangor Daily Whig And Courier (Newspaper) - August 22, 1837, Bangor, Maine .._ ._. 1 ,L y odi will-rind-thr 00 m. Hemlock do .ia WOOD SON, Vest Market Placi le frnn.-nriion oi I on rMISIPMIIt HIS. II. iNEWSPA'FERr RJ: MARCIIAKT IV WEST MARKET PLACE, ivo. 11. Wnijand Courier every Tuesday j. at Two Doil.iri a year.: in advance" oHTS flrnl Kilty Cents if not OAK! within six .THE DAILY VVI1IG AND .COURIER, Dollars a half ye'arly in rrdvance._ AH year, j in be paid in by the, amorjMt due. 'TUG iJANOO.R OOUltlLrH is puOl.siied the'oT- puitTUK "the1 hereby given that JUST EMERSON P -i- A N Ueuvned at Levant, be'crc ihe Le- ihe'lirjr, ol 15KOVVN NKWATER, au-at-1 ol Iliii-hUiiifi GMEjltjWr U. Q.L life firm will be .ci.uducicd under- die. name vi' UKOAVN POIlTtM. 1837. will ia Wbjg Cooner on.the fallowingcunditions cmty, and Uie.j ufi-A-s wUI iresiricily adhered to thrre. insertions in. dnihj nr iiiffkttj anrfoO cents for eavJi wectiT b? con- __ than half a square miff less than a square, H a fions, and 2aceui4 -lor each week it iray be CGJI- fHMonn nf V llreyftftf wil NEW BO-OKSt! HMr'ri anH r -jlj "jjrxp: M.rtrliii Tale'-., hy auibor of by W H Ainswnr.tJi "Adlla" tt> G. IJ. K. James nn Sovjity'j by at this utiiee. Price uly 24. P.- UANGOR. rand promjjilj- exeeutcd_._ A OTIC E. as Auuriiiir-> fll I.HW under lite i linn uT MeUAW PUOR, al No. 11 BBLS. llyUiaulicCe.i.cni, inr -B! _ ATTWyOD A N Pp-K-i-RAlT ti A Ll. K one of rttt-atiuve NtrtioDal V ;N _ _ ._ THATCHER'S. f.-Mun our liuttneti we adued a Wire KiiTiii, he "purpose of" house kvvpijrk u.tf oll.v anrcltii arthe I Call ai bO Main iyeet TntiTt? AARON 'P.'LOWELL ot CO. .urj with t 11 d rFd ays "bTtha. A l by 01'Fraypr of YOU N a H-A-K KtMA N i :1H' h iw i ALL persons ini NK.Y, hj'noie yr unaer me nrm "or WHniIh.K REMOVAL. GUILD; and have taken Store No. CHA3.C. GAGK. 'Jailor and Proper, has re- jireet, nearly opposite the Ponobscol Exchange moved from Nn 3 Smith's lilock to Hudson where ihey have, for -sale a., large stock of Druus on Hammond street, 'Medicines. Dye" SKifFs, French and A On nainbk prime.assnri.meni of. Buck- Paper H.augit'fi.-LrA'c.. al. -verv- low skins, Cassimeres which will be mfide tn JOS. M. WHITTIER, diij warrbiilvJ tu fit luJuCtd 'if choice goods, wla.4i wili be closed al- vtty low prices tor cavh. TI) >M? in want wilffiud iti their I5angor, April 21'1837; A ARCOf L Bailor ry ill siicf Malmp.myFrwme s, Work' do.. Brass Sells; Kntve-t mid Forksr ____ Waiters, Tea Ke-tilps, .Sauce Kitn -Wj.mfSi.vl.; ERST- FJ2ATHERsfi J mi -P.tUtiwj, Live Xieese-aud Russia I UT GECsE Baltimore-; ar he KK KI VED on consiglirneliT day :j.-f........ One'bale'Russia -iw A-'-rteh- ol -tow priced and mcdmrn ai me otu sianu, ut ouutn i 11 i c i. where old customers airline public Calicoes rlbw PnCed blue do; tho stock will be closed cuy. Bv an arrangement wii.tilie I Sfrl W A f .1- -t.- i-- 9 f _ I Mat1' S MATTUKSSSK'S. INGLE and doutile made of the rvf hair .Rrad tlo a gCJO.d Article for under beds, just received and for sale by nov2G SHAW Ai MERRILL. HAIUJ WOOn FXttl SA'-E, Hdrd Wood, dry.-cxit last falj, -c.iabw at any part of ,lhe--cily. Apply to ihe counting of. _ JOSERHW. Block ,i r POSITIVELY i "A nimhlc belter llinn a thh dale unlil July 1st, we shal, strictly adhere lo ihe above." two reasons in view for so duiiis llnii upihcir old itcc-uunts by continually jecejving j-iioJs they Oay. 2d received Goods from'Auctions and other nl low "rates, and fan make iViain will cnhtinuc nn tliv in connexion a pen-ral of i Knjjish.AV 1. Goods and Groceries, where pur- t iMsers ca.-h lor any ol ihe above goods 10 call and cxaniilie BIBLlCAf. ANALYSIS, OR a Topical arrflno-en.i.niii-of of i lll'd l the holy adopted to ihe use ot inmiili.-4'S, bible class i l.linily BJK J.'U. Par-ens. Memoir of Kev. Bela Jarohs.. A. M. eompiJed I Irom Ins lellris ai djournal: Hy Ins daugh- I procured one of the patent Washing Ma- ol character bvH. Sears. cluucs manufacli J. L 24, CO. istf mlorrris the public that he ler, wiin a skelcfi Jusi rec'd by- June 13 UURKK THATCHER.. of H.irvard [Inivers Grand Mrfrrh. Boslbii IConllion. My liark i? on ihe_ wa ,e_rs wiih ciilter pieces. JIIM recM' bv -y-f, T-'HA3'CHER. TluA. WE have jixt'race'iverlS'f ciiesisaDrl boxes Sou- nhoiiij Tea, which we sell al Boston pricey freight added, GRANTDULOWELL CO. CAMPBELL'S KOTJR GOSPELS.- FOUR GOSPEL8, tra.ialateo the- Greeki Preliminary Dissertations nnd and exolanatory. Hy Geo. Camp- hell, D. D. a'new and splendid octavo edition, in 2 volumes- Rec'd by h may27 _DUREN fr THATCH 1T.R. N.EW B.O_OKS._ Dr niivTi Brw work, Niviu NHVO Customers invit'. O 5. 6r7 and 8-4 TaMe Covers, Lmen f) Dam isks, Liiieii Napkins. Uipd'i Eye Dia- B. CLEAVLANH, AT L'AW, t P. Ii.SLtr, and devoted lo Litera- tiilrlrMreni'it-A'or receiveil. Ky SHITR KEN KM OVAL. as _ Waier.aiid they will be attend to all erders IH their line'i.l MrRR-pRi A NEvV volume of this vnKiableandipopiifurpe- riodicrtlj com'menets on (he first ol Jiil' It Capt-MnrfTilt asBToidrirwior, will render it .r-'T-- x. The Clpik Guide or CofYnnOrcial ence, comprising Leilen Itorm's-ol ________; Bills, Invoices. Account Sales, and Appendix con s'chr Tremoni, will be sold 'cheap "at taininj a'rtvice fo yoiliiir Tjajrlftsmehaiul Eqiiautjn ef Commerc-ial-Tcr-ms, by B f Foster. Treaties on Bread and Bread Syl- Memoir of Charlotte Ilamilion. Memoir of Ch'nffes Rail, a bfack man. written by himself, being Ihe 1st vol ol the CRhinei ol Frce- donvj tfliteH hj- Prof and Gerril Smith. The Rnglish Obiectioiis to a Bap- .listiersiau.aLthe-Npw.TRSliipierii- ,_J_. T.he Cidi, nent volume bounri m Library ol Health anrl nTIier No {4-.of the Temper_nnce Tales. Kittv. Graft an 'llie baneful effects ol'cider. Just and for sale by DUREN A'tCHF.R, T R.U x K s, ri DRUNKS for_iile. at 60 and I 70 Main street. Those in want.from a small .'slil'. k( a sft A'. P. LOWELL A CO. in aft M'hall'syaDi.ih Cieaxs, a ariicle, for EMERY fcSAfyiNJCv. dec9 West Market Place. id6o YAiibs COLORS niost-desKnble, and al luiusnal low ori- .cesby. S. A: HVDE. SFAIV ISM CIGARSj_ M Su llliill CigSfS, just jei-M dml fur snip by jvO GRANT FLINT. TO SELL OR LET. PIANOFORTES. Apply at A M WUUIJ SE SON'tf mnrchS Auction Office. feb7 Ground Plavier, for sale by EM'R'RY No. 18 West Marketplace. -tllB Iwrebv JTIVB- notice they together with certain articles of Form- b nf Carpfts. Rjds, riding, ChalrV; ate. 16e lease to co'mrnertce'aooui Irsi of.April ___ ___ -.7- 'I'lre Baneor favornhly to re- 81356111165" "Pppavlouir ve.rv ronvenii'iiily arranged -in every purl, nnd WHJI ihe regulations and order necessary in a well comlorled Hotel, this> osfnnTiiihmenl oilers peculiar" for n profitablebrrsineas. Blir for "reOilling Liqurtts is in be in the -H.oqse., Iv.-LhqCol'ihe Sub en- AMOS apror. -r Q.nV IUILV -----No. 7 fuut of Main NEW GOODS, KEC'Dlast steamer Ranjor, by AD CO- No_fiO Mnin ptreet sale a well (wo'story Dwelling near Philip Coombs' Pew number 1 T6 in Rev..Mr. Pomroy's meeting trouse. By Auctioneers. LKT. A small llfinse PliiSfrsiiWi given the fourth of April tnqoire of march23 S, A. HYDE, 4 Smith's block. E pay a pn mium for (iuldaad Silver, ai street. WE pay a Alain 60 Subscriber purchased the enlirr I stock ot Goods Co. and laken fhe Sloie in Wall stref i, oppuiiie Hit Mercan- tile Bauk. rcc.eiuLy .occupied offers for sale a geiieral ol W. 1. (iiiodn and Groceries, (Mockery, China and Glass Ware, Hul- low and oihcr Ware, which will be suld on rea'-onable terms. cs manufactured by Col. Ray of this city, and Ihnl he LS nnw rcacli' toeilhtr VIST, iambic- vmL inaehtne and do their will take the clotnos homeland reiurn them, rough dry or ironed at reasonable raies. The washing fnr a common iized family can be done-in an at a charge of only about WM.SUTCL1FFE. Orders left wiih MfJ., W. MardenarDr. Ayer will -I Nov.21, 1930. dec3 the underslgnwl have seen trie operation nf Mr SutclifTs .Machine arui conlidenily t we iV BOOKS. -Huubard Virtue Wins MOSP Smilh'l j. Block, romprJsiiig a gieat variety of Staple and Fanc-v IVv Goods, will be offered at cost, for ihrce months, Vy 5. A. KEGS LARD n c'nod article for fnmilyosc, FOSTER'S by. ._......YOUNG--V HARRIXAN, BOOKS. Desired to lead the learner J upon simple principles, rn.m the first roifjmenH i t perfect knowlerlrc-of the An: I.VJ r.ljtj A- imnrxvoH Plan T.....I----- L_ WARE Rtjosjs, "ssf? .No. 60 MAIN STREET. JUST received and now op ment Furni.lnM inp ft qpod assort- ihe a- liove which will be sojdai the lowest prices lor Cash. HARDWARE Brnss Fire Setts, brass head do., and brass ticnd Shovels nnd Table and Desert Knives and Caivcrs and Forks. VJOfr arid'tow priced Toa. Ten Kettles, Gridirons, Pewter and lined Porringers, Sauce _ i llie inuible auJ of lirneilS ruling ho orzon- lid and diagonal lines, and selling copies, are cij, und the of is f really equaled. Adapted to SrhooK and Private Ins rnc- timi, -by B F. Footer, Teacher of Writing author of "Developement ol Carstair's Prize Essay on the best of Teaching ''Foster's Penman- ship." tii'l by ._ '_ DL'llCN ..J Pinj, Dornrrs.plnicd ond iron tiiblc nnd tea Spoona, hrss6 Lamps, Blacking.Jnk, Scissors.pocket Brjtk, Brass KeHfeSj. Cupsj green arid blue glass Spectacles, Harps, dtc, BRITTANIA WARE Rlock Tin and Rrittania Coffer and Ten Pots, BtiiJ-k Tin Ladles; Tea aiid Table Spoojis. ccc. RRII.SHFS.. Floor and. unhan- 'Itod Cloihes a-nd fow prifed Hair do. Tooth do. FANCY ARTICLES Rver'Pointed Pencils, Soup. -LopHon Soap. Ivory 'Vmhr, C t F PrMrinp ''o Fancy Wallnts, Pocket Books. Read Purses, Cologne Water. ISO Whips a l Com june.iO A-ARON D. LOWELL" ft. CO. Tt I bv the seventeenth Legislature, January 1837, CohweKs'Swepl away, or some "populir clercp- lions exposed a sermon aYliverrH On Pgn Dny, April fitn 1S37 si ihe firs i clituch in Newbury. flj repMhy 'oyRKN THATCHER- juneiS LAWS 183T- Laws for just recM and for by SAJ11'ti JFF-CiNO. junelfi fN L Augnst, I83ii, a boree straVed awity 7rhAi af Old Town Hit was hdw-t tail and. of midAHrif for-nwl He WBH old. "yet helia'd'a t A O'i A ;iHJREN f reeaivedbj! rfyjjrid V( ARD WARE. Twine Reels, Mop H-indles, Wash Boarrls, Rollins Pms, Chil- Iren'is Willow Wheelbarrows, Nests of Boxes. and [jajn.led Pails. Travelling iron bound pAinif Jlarkrfi do. CloJhes Pias.tj Entry c. AFT embracinf Dininjr nnd Tea Ware of n.d es r HAY AND BUNDLES HAY; For sale hv Polly
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KENILWORTH, N.J., Dec. 27 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP) is scheduled to announce its sales and earnings results for the 2007 fourth quarter and full year on Tuesday, Feb. 12, 2008.
At 8 a.m. (ET) on that day, Schering-Plough will conduct a conference call to review results for the 2007 fourth quarter and the full year. Fred Hassan, Schering-Plough's chairman and CEO, and other members of management will host the conference call.
The call is scheduled for a later date than usual to allow time to properly prepare consolidated financial results reflecting technical "purchase accounting" adjustments for the November 2007 acquisition of Organon BioSciences N.V.
To listen live to the call, dial 1-877-656-9664 or 1-706-634-5003 and enter conference ID #26183610. A replay of the call will be available beginning later on Feb. 12 through 5 p.m. on March 11. To listen to the replay, dial 1-800-642-1687 or 1-706-645-9291 and enter the conference ID #26183610. A live audio webcast of the conference call also will be available by going to the Investor Relations section of the Schering-Plough corporate Web site, http://www.schering-plough.com, and clicking on the "Presentations/Webcasts" link. A replay of the webcast will be available starting on Feb. 12 through 5 p.m. on March 11.
Schering-Plough is an innovation-driven, science-centered global health
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SOURCE Schering-Plough Corporation Copyright©2007 PR Newswire. All rights reserved |


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Okay, it grows rapidly, it tries to take over everything. It doesn't get that tall (based on last year). It's very soft and furry. The roots snap off even if I try to carefully dig them out. So, what is it and what do I want to do with it? Can I eat it? Should I make into a salve to cure dry skin? Can it kill Bermuda? Should I declare war on it? |
Follow-Up Postings:
- Posted by slowpoke_gardener 6/7 (My Page) on Fri, Apr 18, 14 at 21:18
If it kills Bermuda, save the seeds, you will be rich. |
what was the mature size of it? |
- Posted by ChickenCoupe 7a (firstname.lastname@example.com) on Fri, Apr 18, 14 at 22:26
is the stem square? almost looks like some kind of mint. |
- Posted by Slimy_Okra 2b (My Page) on Fri, Apr 18, 14 at 22:31
Looks more like a kind of nightshade to me, in which case it's poisonous and should not be eaten. |
- Posted by wbonesteel 7 (My Page) on Fri, Apr 18, 14 at 22:54
Heh. That's what I was gonna say, Slimy. 'Don't eat it! You don't know where it's been!' iow, if you don't know what it is, don't eat it. Okievegan, If it is nightshade, though, it can be useful for other purposes. |
So, to sum up, it could be mint or a biological weapon? Y'all don't leave me with much of a middle ground. Mom, I'm not sure of the mature size of it. Last year, I kept trying to kill it. Emphasis on the "trying" because I obviously failed miserably...it's already back. |
- Posted by wbonesteel 7 (My Page) on Sat, Apr 19, 14 at 10:49
The pic offers a look at some of the smaller leaves. We have no idea of the color, shape and structure on the main stem, no flowers - or color, size and shape of same. There honestly isn't enough information to judge, here. So...if you don't want it in your garden, kill it...with extreme prejudice. Cover the area with cardboard or black plastic, weighted down by rocks and leave it there for a few weeks. ...or use roundup or another appropriate weed killer, if it won't endanger pets or other plantings. Pull, dig and hoe, mebbe....and keep pulling, digging and hoeing, as needed. One definition of 'weed' is simply a plant that is growing where you don't want it to grow. e.g. to some, if a tomato is growng in their roses, the tomato is a 'weed'. So, if the plant you've asked about is growing where you don't want it, kill it. |
Here is a link that might be useful: smooth groundcherry
The picture I had posted WAS two plants...not just stems off a plant. Here are a couple of pics of them in the yard. Please excuse the dog poop, but they are in her area. |
MiaOKC, I've been looking at a lot of sites about ground cherries and I am now convinced that you are right....I've got ground cherries. I'd have more if I had found this out sooner...I ripped up a bunch two days. :( So, verdict is in, eat it. Though, looks like Cookie's bathroom area will have to be moved. |
Okay, so this made me giggle: "Ground cherries should be started from seeds indoors, approximately four to six weeks before your last spring frost date. They can be started in cell packs or soil blocks. They can be slow to germinate, but be patient. Once they get going, they will grow steadily until it's time to start hardening them off. Harden them off and plant them out after danger of frost is past." I'd never have any if all that work were really necessary!! I wonder where mine came from? |
- Posted by ChickenCoupe 7a (firstname.lastname@example.com) on Sat, Apr 19, 14 at 16:07
The USDA database says they are native and prolific throughout Oklahoma. I've not seen one, until now, the entirety of my life. What an exciting find. I wonder if they can be cross bred with tasty heirloom varieties? I wonder how long it would take to change the strain and if the new strain would weaken their invasiveness, make them more edible . e.g. How awesome (except they like to grow in Cookie's bathroom)! bon |
Okievegan, our house came with them in the flowerbeds (along with lots of sticktights, etc.) from neglect. We let them grow the first year to find out what they are, thought they were ornamental Chinese Lantern plants. However, for us the husks never became anything that was edible. They didn't fruit out inside the husk, I don't think, but the husks would open and drop a billion seeds. They creep along, rooting along the stem kind of like bermuda, and spread like crazy in our flowerbeds so we ultimately decided to pull them. It's taken a while to get where we only have a few. I went out today and saw some babies. Snapped a few pics with my phone to show you what the baby in my flowerbeds looks like, will post them in a bit. I'll see if I can find the thread where OKGWers identified them for me, too. |
- Posted by Slimy_Okra (My Page) on Sat, Apr 19, 14 at 19:48
Ground cherries are delicious! Wait for them to drop from the plant and store them at room temperature for a day or two before eating them, for best flavor. |
This post was edited by Slimy_Okra on Sat, Apr 19, 14 at 19:49
And here's another. Often the leaves are totally chewed up, and lots of tiny babies near the bigger ones (see lower right). |
That's a brown snake...they're very common in Oklahoma flower beds ;) They eat slugs for one thing, yes I agree, Ground Cherry of some type...just remember this: (excerpt from a online journal) Physalis mollis, commonly known as smooth ground cherry, has been used as a fly poison. So in other words, if you don't know...do be careful with eating it. |
Well, mine is definitely not smooth. It's so soft and fluffy that I'm tempted to cuddle it. |
- Posted by wbonesteel 7 (My Page) on Sun, Apr 20, 14 at 1:37
Ok. That's a new one. Someone looks at a weed in their garden and cries, "Fluffy!!" |
Not a weed....ground cherries. Don't try to make me out as a weirdo. :P |
I grew several varieties of ground cherries on purpose last summer, hoping to get fruit for pies and jelly. The plants became huge monsters up to 4-5' tall and about as wide. They encroached on everything around them and really didn't produce all that much fruit. It was such a small amount that I didn't even pick it . We were in various stages of drought, which likely didn't help. Granted, they were in the new back garden which was planted for the first time last year and the soil wasn't improved at all, but other veggies, flowers and herbs grew great all around them and were very productive, so I don't think the soil was the issue. I considered them a total waste of space. This year I going to put down cardboard on the ground where they grew and cover it with a thick layer of half-rotted hay and grass clippings. I want to be sure that these plants and their descendants don't grow in our garden this summer or ever again. We have them growing wild along a roadside a couple of miles from our house---along a fence line beside a gravel road near an old farmstead where someone runs cattle but nobody lives. I've marveled at how tough the native ground cherry plants are, considering they get no care whatsoever and we spend much or all of most summers in drought. I've never noticed that they produce very much, though they do flower and form the little paper husks in the summer months. These are not something I'll ever plant again. Maybe they are productive in better soil and with more rainfall, but in our garden about the best thing you could say about them is that they survived a dry, hot summer. Okievegan, Because they are in the nightshade family and could be harmful to Cookie if she ate them, I'd kill those invasive things. I don't know if you can dig down deeply enough to get the roots. If you use synthetic herbicides, one of those products might kill them. I don't use herbicides so I am going to try smothering them before they sprout out back. Dawn |
- Posted by wbonesteel 7 (My Page) on Sun, Apr 20, 14 at 9:58
See! I was right! Kill it. okievegan, we're gardeners. We're ALL kinda weird, really. :D Have you ever noticed the looks your family and friends give you when you go on and on about your garden? You're all excited and enthusiastic, while behind that fixed smile on their faces, they're thinking, 'Gardening? What's exciting about that??' Or even strangers..."That's a beautiful garden!" they say, just before they give you The Look. ;) ...because you've got dirt under fingernails and mud on your knees...and the wind has blown your hair into a disheveled mess. ...while your face is plastered with the biggest smile in the world. |
Hahahahahaha....wbonesteel, that is exactly how I view people who DON'T garden! Dawn, my yard is full of things that are poisonous to dogs. Cookie, thankfully, has never been the type to graze or chew on anything other than dirt, occasionally, when she has a stomachache. However, I will continue to snap off those ground cherry seedlings because I certainly don't want them to take over the whole place. Digging them up just isn't possible. Last year, I watered the area really well and then tried to the next day...couldn't find roots! I'd be digging around a little seedling, looking for the root, when it would suddenly snap off and it would be like a root never existed beyond the few centimeters left on the seedling. |
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Rick Santorum suggested Thursday that Republicans would be taking such a risk with Mitt Romney's "Etch A Sketch" shifts on core principles that they should instead reelect President Obama, drawing immediate criticism from his GOP rivals.
"You win by giving people a choice. You win by giving people the opportunity to see a different vision for our country, not someone who's just going to be a little different than the person in there," Santorum said while campaigning in Texas.
"If they're going to be a little different, we might as well stay with what we have instead of taking a risk of what may be the Etch A Sketch candidate for the future," Santorum said.
To read more on this article at The Hill go to http://thehill.com/blogs/blog-briefing-room/news/217765-gop-rivals-blast-santorum-for-suggesting-obama-preferable-to-etch-a-sketch-romney


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Sleeps | 7 |
Bedrooms | 3 |
Bathrooms | 2 |
Half Baths | 1 |
Property type | cottage |
Minimum Stay | 3 - 7 nights |
Gorgeous, very private location on the ocean. Welcome to South Light Cottage. Read renters reviews to hear why others love this place! Newly remodeled spacious home, with large deck, great open kitchen living space and ample sleeping space. Spacious deck seats 10. New appliances, large well equipped kitchen. Wonderful space for an extended family vacation or reunion.
Located at Bailey's Mistake, known for its timeless natural beauty, absolutely spectacular scenery with headlands, islands packed with seals, beach roses and private beach. Few are fortunate to stay waterside in this lovely location. Hiking trails abound, the bicycling is great and bring your kayaks or rent them in town for an active vacation. Or cozy up to the view with your books or writing materials or artistic endeavor and you will forget your cares as the salt air refreshes your senses. Much more than the basics, this comfortable home and location provides a respite from the world. Lubec is a world apart.
Magnificent Location: Pristine Bailey's Mistake is situated on the Atlantic Ocean and this cottage is perched near the water's edge. A lovely island that can be accessed at low tide, a sheltered beach and nearly one mile of accessible shore land are just outside the door of this newly remodeled and open cottage. Spectacular views of the sunrise, shore birds, eagles, and the sparkling blue water of this hidden treasure will greet you each day. Tucked away in an untrafficked area, you will feel the peace and the beauty of Bailey's Mistake. Views out to Grand Manaan Island, in Canada.
Enjoy Campobello Island in New Brunswick and visit the Roosevelt International Park with the lovely Fireside Restaurant, a restored gem. Visit Jocie's Porch for coffee and interesting vistas across the bay. A unique car ferry can take you to Deer Island also in New Brunswick.
There is much to explore in our vast area ~ and this house is a great jumping off point. OR - simply relax by the shore with only the sea breeze to ruffle your feathers. Call or email for more information.
Hiking & Kayaking: Bring your kayaks for beautiful afternoon paddles at Bailey's Mistake. Or rent in town! Watch the seals on the islands and tuck into rocky coves. You can also rent kayaks and bikes in town. Hike the Bold Coast Trail in Cutler and experience Maine's Coast at it's most spectacular. Visit Quoddy Head State Park and the Easternmost Point of the Continental USA. Or hike Hamilton Cove, Boot Cove, the Pike Lands, Commissary Point .... and more.
Quietude: Enjoy the peace, the quiet of your surroundings. Reflect, read, totally relax in this inviting environment. The fog may surround you one day in a cocoon of vapor. Another may be a sparkling, crystal blue day with ocean breezes. Be ready for the pleasant surprises
Visit Canada - minutes away is Campobello Island and the Roosevelt International Park. Golfing, beach, trails, whale watching - also available on the island.
Rate Period | Nightly | Weekend Night | Weekly | Monthly | Event | ||||
May 29 2015 -
Jun 19 2015
3 night minimum stay
Jun 20 2015 -
Sep 5 2015
7 night minimum stay
Sep 6 2015 -
Oct 24 2015
3 night minimum stay
Pet Fee | $100 |
Tax Rate | 8.0% |
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.


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I recently cleared out the greenhouse for the season and have a few things that will not be able to fit after this season. I have a big Philippine mango (5'-6'), a Hak ip lychee (about 4'), a Emperor lychee (about 4'), and a Miracle fruit tree (about 2 feet and producing berries). All are too big to be shipped except maybe the miracle fruit. Just let me know what you have. I am in central FL but I'll be making a trip down to South FL this summer. |
Follow-Up Postings:
- Posted by mango_kush 10b Hollywood FL (firstname.lastname@example.com) on Mon, Mar 7, 11 at 19:16
Ill take the Miracle fruit off your hands, I think mine is toast. Let me know what you want. If you trade for things wont your greenhouse be just as full :) |
Yea, I am kind of looking to get rid of some things that are taking up a lot of space that I either have duplicates of or don't like the fruit of to make room for something that I might like better. I don't really have anything in mind. Just looking for something interesting that I don't already have. Let me know what you have available. |
I have a Cogshall mango in a 25 gallon pot . It is in OK condition, last season it produced 5 fruit to maturity. This year no flowers, as I did not really give it very much care. I sort of lost interest in growing a potted plant, and I already have a Cogshall in the ground. If you are interested, I will trade it for your Hak ip .. |
- Posted by tropicaliste 7b (My Page) on Mon, Mar 7, 11 at 22:50
It's a shame you're all the way in FL or I would definitely be interested! Especially your mango... :) |
ME too I second that. I would take the Phillipine off your hands. have you had any fruit from it? I thought I remember someone saying that the Phillipine is similiar in taste to the Atualfo. If there is any truth to that, I would be on a search for the Phillipine. Ah, on second thought maybe it would be better for me not to know!! Hey Sleep, Thanks for your input. I really would like to know since I have become crazed about growing mango trees in pots! Andrew |
- Posted by mango_kush 10b Hollywood FL (email@example.com) on Tue, Mar 8, 11 at 8:04
while Ataulfo and Philippine are similar, they are not identical like Ataulfo/manilla/champagne may be |
Andrew, I would guess that if taken care of well, the Cogshall would have produced more. I am very much a novice with potted plants, and I pay way more attention to my in ground trees. I also bought a 15 gallon Pickering last year from pine Island. I was amazed at how it had 5 large manogo's on it at the nursery, while it's trunk was only about as thick as my thumb. Fruit was very good. I planted it in the fall, and this year it did not flower. But I think that it would be a real winner for a potted mango. |
jsvand5, would you be interested in a Kwai muk tree for your emperor lychee? T- |
I may be interested in the kwai muk. What is the size on it? does it produce good fruit? The emperor is flowering for me now. 3rd season in a row it has fruited for me. I'll try to take a pic for you. Do you have a pic of you kwai muk? |
wow, I was not expecting to see such a large tree. I think that may be too tall for what I need. Thanks for the offer though. |
- Posted by tropicaliste 7b (My Page) on Fri, Mar 11, 11 at 17:34
Def a super nice tree. What's the issue with it, a lack of room in your collection/porch space? :) |
jsvand5 I'll get you a pix tomorrow. I haven't tried the fruit yet. It's an attractive tree though and not always available from what I've read. Tree is about 4' tall. |
That Cogshall could use some pruning. |
jsvand5, my camera is acting up so I'll take a photo with my phone and email it you in the morning. |
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Rowan Pattern Books - Mini Collection - Kidsilk Haze Stripe and Rowan Kim Hargreaves Pattern Books - Spirit are both similar books: women category.
You may enjoy taking a look at the , and Berroco Ultra Alpaca Coburg Pullover kits all using Berroco Pattern Books.
If you like Berroco Pattern Books, then you may be interested in the different ways we've used it. Visit our Baby Blanket, Baby Gift, and Crochet corners to see some ideas.


text: Ok, I just got an elliptical for Mothers Day, have never been on one in my life. After the first minute of being on it, my thighs were on fire and I could feel my heart pounding through my stomach, is this normal? Its a $200 Weslo Momentum from Walmart and seems a little hard to use. I have it on the easiest resistance level and it seems a little hard to get going. Im not sure if thats how its suppose to be, or If I have to keep using it to break it in. I hear you can burn 300 plus calories in 30 min, but I cant even stay on it for 5 minutes without feeling like Im going to die. Any feedback would be greatly appreciated,thx!


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how high well does my boat point?
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Re: how high well does my boat point?
Originally Posted by
Instead of shot gunning the problem, I'd suggest starting at the beginning. Someone said earlier fair the bottom. I assume they are referring to a new bottom paint to reduce unwanted drag. Next, loosen all your standing rigging and tune the rig properly. contrary to an earlier post, two year old dacron sails are new... two year old laminates are not. Properly cared for dacron sails will last 10, 12 years. Balance the boat when sailing. If it's not balanced, nothing else can be repeated on a consistent basis. Then you can send picture, gps tracks, apparent wind readings, etc. we can provide a lot of help with just a little more data as long as the conditions are repeatable...eg a balanced boat.
I didn't say two year old sails went any good, I said they would start to effect performance. If you look at any racing class that uses Dacron sails (the J-22 comes to mind) there is a definite replacement cycle for sails. When I was racing the 22's we replaced the sails before every big regatta. So a new set for midwinters, new set for nationals, new set for North Americans, ect... A jib with 10 races on it is a noticeably worse pointer than a new one.
Note that this would be stupid for cruising/day sailing, even performance sailing unless you are sailing at the top of the fleet.
Greg Rubin
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Wycliffe (WYC) | New International Version (NIV) |
15 I pray not, that thou take them away from the world, but that thou keep them from evil. | 15 My prayer is not that you take them out of the world but that you protect them from the evil one. |
Copyright © 2001 by Terence P. Noble. For personal use only. (Wycliffe Bible) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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Nancy Rhomberg
Nancy Rhomberg joined Vance in January 2005 in the circulation department and moved to The Packer sales staff in February 2006. She covers all territories, selling the directory and classified advertising for The Packer. Before coming to Vance, Nancy was part owner of a printing company for more than ten years. She was the customer service manager and handled several other aspects of running the business. Nancy enjoys spending time with her husband and three children, reading and walking their dog.
DIRECTORY AND CLASSIFIED SALES REPRESENTATIVEe-mail: email@example.com
phone: 913-438-0702
fax: 913-438-0692


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The Sino-Singapore Tianjin Eco-City Investment and Development firm has signed another three industrial land deals, involving over one billion yuan (S$203.9 million) in investments in the Eco Industrial Park and the Eco Business Park.
Tianjin House Construction Development Group Co Ltd, one of the largest eco-building-materials companies in China, intends to invest 300 million yuan to develop low carbon and energy-efficient green buildings in the Eco-Business Park to house the first sustainable housing R&D institute in the country.
Keppel DHCS, Keppel Integrated Engineering's wholly owned subsidiary, plans to operate and develop a district heating and cooling system in the park.
Sichuan Neautus Traditional Chinese Medicine will also invest 500 million yuan for the processing and dissemination of Chinese herbal medicine for Northern and Eastern China, as well as export markets.
Tianjin Eco City also announced a strategic partnership with three leading companies in the eco technology field – Singapore Technologies Electronics (ST Electronics), Japanese firm Hitachi Group and Chinese firm Envision.
"This will complement the eco development needs of Tianjin Eco-City and create high quality job opportunities to draw new residents into the Eco-City," said Goh Chye Boon, CEO of Tianjin Eco City, commenting on the steady stream of investors into the Eco City.
Tianjin Eco City also signed a nine-billion-yuan deal with one of the top developers in Malaysia, Sunway City Bhd (SunCity), for the development of an integrated LOHAS (Lifestyles of Health and Sustainability) community.
This joint venture, which includes mid- to high-rise apartments, retail malls, schools and premium waterfront villas, will have over 0.7 million sq m of gross floor area that can house about 5,000 households. It will also include unique features like green houses for organic farming, hydroponic gardens, youth parks and green spas. Earlier, Sunway had indicated an estimated price of about RM500 (S$215) psf for the SunCity houses in the Tianjin Eco-City.
The Sino-Singapore Tianjin Eco City is a joint development between the Singapore consortium led by the Keppel Group and the Chinese consortium led by Tianjin TEDA Investment Holding Co Ltd.


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Thanks guys, & please spread the word about this posting, maybe if enough of us cry out for this we may actually get some attention, & Ozzy may think about doing it, lets all keep our fingers crossed anyway!
Thanks again all!
"Being sober on a bus is, like, totally different than being drunk on a bus." - Ozzy Osbourne


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Is it better to seat the parents of the bride and groom at the same reception table or at different tables?
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See More: Wedding Reception Ideas , Wedding Receptions


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A studio shot of a model from France who was studying here. I tinted the image as it enhanced the cold, hard, direct feel of the image.
Camera: | Can 5d |
Recording media: | RAW (digital) |
Title: | Amandine |
Username: | monstersnowman |
Uploaded: | 12 Oct 2010 - 4:35 PM |
Tags: | General, Model, Nude, Nude / glamour, Portrait, Portraits / people, Studio |
Votes: | 45 |
Excellent portrait. Really like the tones and the eye.
Nominating Constructive Critique
Thanks for the comments. @ Ron yes she was a beautiful model and my very first full session with a model that wasnt someone I knew .. come to think of it .. the last as well. Not done one since .. lack of confidence. Thankfully got quite a few 'keepers' from the session.
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Beautifully rendered....stunning image. Wonderful model but wonderful light and tones....this really is going straight into my favourites for further inspiration and straight onto the shortlist of just being so damn good.....wonderful image. Portraiture at its very simple and effective best.....
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Cheers johnnyboy114 .. glad you like it. It was my very first studio lit portrait and I hope to do some more.
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You should do more! If this is a first hit, loving seeing more in the future! And good PF too!
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text:
Reviewed Flour's Famous Sticky Buns
Jul 24, 2013 in Food Network Community Toolbox on FoodNetwork.com
"I have the Flour cookbook, and the reason 6 eggs ar listed is because the brioche recipe as listed here is not complete. The brioche recipe in the book goes on to make loaves of brioche bread, so you use the 6th egg as an egg wash if you are making loaves of bread. If not, you take the brioche you made, and make into into sticky buns, or several""


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The school board offered incentive for superintendent to move from Woodbury.
Valeria Silva
The St. Paul school district has approved $26,250 in relocation expenses connected to Superintendent Valeria Silva's sale of her Woodbury home and move to St. Paul this fall.
Her move came at the request of board members, who wanted her to live in the city she has served as superintendent for two years.
Silva had worked in the district for 25 years before she was hired as superintendent in November 2009. At the time, board members agreed it wasn't a good economic time to put her Woodbury house on the market, but in August of this year, they offered her a $40,000 relocation package as an incentive to make the move.
In October, according to real estate listings, she sold her house in Woodbury for $365,000 and bought a home in St. Paul, the district said.
By living in the district, "all the matters that affect the district are also affecting her personally as well as professionally," Elona Street-Stewart, the board chairwoman, said at the time. "This is nothing unusual or unique to our district."
The relocation package raised some public protest because the district had laid off employees to counter a $25 million budget shortfall.
The amount of the package was determined with the help of local housing experts, who gave board members estimates on the price of moving and how long it could take for Silva to sell her house.
According to an itemized list of Silva's moving costs approved by district officials last week, she spent $4,176 in moving fees, $2,241 in financing fees and $19,831 in closing costs and Realtor fees.
Daarel Burnette II • 651-735-1695 Twitter: @DaarelStrib


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See your white on these designs right now!
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Gorgeous invites and very helpful and quick responding staff
Tender Tree Rectangle Invitations I would absolutely recommend dealing with this company. Any changes or alterations to invites and staff was calling or emailing me almost instantly. Invitations were quick to arrive to Canada. Very high quality invitations!


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I am planning on using a dual body CO2 Beer regulator to dispense/carb two beers at one time... would i need an air distributor to serve multiple kegs?
Tap 1- JubelAle Clone Tap 2- Evening Bite Pale Ale Tap 3- Twilight Clone Tap 4- Dicks Danger Ale Clone "Today I felt like burning some calories....So I found a fat kid and set him on fire"
I use a dual body reg. I have 1 reg feed a single keg, and a 3-way on the 2nd. You can add as many kegs per regulator as you like. If you have a huge keezer, you can do 5 on each.... Without an air distributer, you will only be able to carb/serve 2 at a time. I just add a new keg and let it sit for 2 weeks at serving pressure, so it has time to carb up.
So, as long as I use only two kegs at a time (one to drink and one to force carb until it's ready)I will not need an air distributor?
Sweet guys! Thanks for the help!


text:
FL Studio 9 9.0.3 User Reviews
A newer version of FL Studio 9 is available.
Or, Learn More About FL Studio 9Excellent
"This is an Excellent program"
Version: FL Studio 9 9.0.3
This is very simple to use and extremely powerful. VST's load easily, kits added easily.
Recording is not very good,
This is great for up and coming producers
"Not your usual workflow, but extremely powerful"
Version: FL Studio 9 9.0.3
65% discount and free beginner vids here: http://nfurl.us/buyfl
FL is extremely powerful and has one of the best audio quality of any DAW. The program is always being updated. One of the strongest points is that you get free lifetime updates.Cons
Might have a steeper learning curve due it large amount of features. There is a limited time promotion to save 65% and get free beginner videos and access to over 2000 files (kits, projects) if you go here: http://nfurl.us/buyfl
There is a limited time promotion to save 65% and get free beginner videos and access to over 2000 files (kits, projects) if you go here: http://nfurl.us/buyfl
Bottom line is that this program is not only one of the best sounding and most feature packed programs for audio production, but it also has a great price point considering you will get free lifetime updates. -
Version: FL Studio 9 9.0.3
its easy to use lots of new features and zune up,and u can save stuffs in demo version
the price that first came out
"love I make Music With It www.youtube.com/musicwavesman"
Version: FL Studio 9 9.0.3
Very good user iterface. Come see my videos www.youtube.com/musicwavesman
It isn't free
I love this fl studio 9. check out why www.youtube.com/musicwavesman
"10% Discount http://affiliate.image-line.com/BFHEHAH486"
Version: FL Studio 9 9.0.3
+ Piano roll and step sequencer are so smooth
+ Tons of plugins included, fx and instruments
+ Samples are pretty nice.
+The FPC samples are really great, nice acoustic drum sounds.
+Free Lifetime UpdatesCons
- Playlist can be a little hard to keep organized.
- Wish it came with more color schemesSummary
You can't compare FL Studio to other software. It's so unique and fun. It's a must have for any computer musician. At least give it a try. Even if you don't use it much, the free lifetime updates makes it a great investment for now and the future.
I love how fast I can just create a beat in the Step Sequencer, paint that patterns into the playlist. Then create a melody in another pattern, and paint that in the playlist. It's so easy.
Recording audio is great with Edison. Slice-x is a great sample slicing tool. Maximus is a top notch mastering plugin, just a great value when included in the Signature Bundle.
I can use my computer's keyboard or a MIDI keyboard to record my notes. Or just paint them in the piano roll. So many options and so many ways to get things done. Just plain fun to create music with FL Studio.
Support is fantastic, the guys at Image-Line are great. They take good care of their customers. If you want to save some money buying it, buy it directly from Image-Line (lifetime free updates included), and use this 10% discount link http://affiliate.image-line.com/BFHEHAH486
You'll love it. Just practice with it and read up on tutorials. -
"practice is best. 2 thumbs up"
Version: FL Studio 9 9.0.3
i paid for the producer xxl i'm happy with it! in fact im listening to 85% artist use this for beats or wha ever
stretching the tracks in main colume are confusing cant get the 8 bars stretched to 10 or 24
this is not for lazy minds and self destructors, its easy enuff to keep trying and bettering the ART of making music. me myself i JUST DI IT!!! however i dont have the whole thing in the bag but i will get there so till then enjoy and music is the lover of many souls.
"Very Powerful Software!!!"
Version: FL Studio 9 9.0.3
Loads of studio control
More suited to making beats than real live recording
Good for recording and making beats, loads of control, able to be used inside other recording software (rewiring) e.g. inside Adobe Audition or Reason. Can be coupled with music keyboard through MIDI or you can use computer keyboard to play and record music.
"FL Studio is a serious music production studio"
Version: FL Studio 9 9.0.3
Very simple to use, great effects and loads of free samples included
Yes the top end version is a little expensive, but less than other products on the market
10% Saving - http://affiliate.image-line.com/BGCHFHH490
Forget the editors comments, FL Studio goes from strength to strenth. Compared to other software on the market it's very simple to use and you can be creating Drum & Bass through to Soulful House in no time.
Forget the editors comments, FL Studio goes from strength to strenth. Compared to other software on the market it's very simple to use and you can be creating Drum & Bass through to Soulful House in no time.
The top end version give us more than enough sounds and effects to create some nice tracks, but if you tight for cash make sure you buy the "Juice Pack" for the low end version. For the serious producers out there, FL Studio neatly interfaces with third party plugins such as Native Instruments "Komplete 6" givng you access to some really highend sound production.
Absolutly love this product
Peace Out
How3 Recordings
Updated on Mar 13, 2010
The top end version give us more than enough sounds and effects to create some nice tracks, but if you tight for cash make sure you buy the "Juice Pack" for the low end version. For the serious producers out there, FL Studio neatly interfaces with third party plugins such as Native Instruments "Komplete 6" givng you access to some really highend sound production.
Absolutly love this product
Peace Out
How3 Recordings -
"User-Friendly, Pro Software, Great for beginners"
Version: FL Studio 9 9.0.3
This program is easy to use, has 64 channels to work with, limitless loop channels, great automation features, and is just plain fun to operate.
It's a great program, but you'd better have a good computer to work with. Something along the lines of an "average" computer, and you'll be having issues after the eighth channel with effects. Slower computer problems consists of cracking sound,ect
I've been using this program for about two years now. When I started, I had zero knowledge of music production, or any music programs for that matter. I had a little knowledge of keyboards, piano, and guitar; and that was it. In about an hour I had my first loop spinning, and about a month later, was on my way to creating some cool trance beats. This program is very easy to use and maneuver through. It can also be a learning curve for those trying to get into music production. I highly recommend this program to anyone knew to the mixing world.
Now, for the cons.. The only con I will give this program is that is uses a good chunk of memory to run multiple effects on multiple channels. If your computer is the average computer, you'll do great in the beginning; but will need to render out small bits to figure out where you are later towards the end of your production. However, if you have a rather fast computer, you shouldn't have any worries at all. -
"the FL Studio 9.0.3 is an absolutli great programm"
Version: FL Studio 9 9.0.3
you can make everyting wat you want
there is nothing i like this product.
"the FL Studio 9.0.3 is an absolutel great programm"
Updated on Dec 15, 2009
Updated on Dec 15, 2009"Great program."
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Once grilled, eggplant comes into its full glory: tender, creamy flesh with a satisfying meatiness that makes it ideal for our Vietnamese-style Grilled Eggplant Banh Mi Sandwich.
Cooking Light JUNE 2013
1. Preheat oven to 375°.
2. Combine vinegar, sugar, and salt in a bowl, stirring until sugar dissolves. Add carrot; let stand 15 minutes, stirring occasionally. Drain.
3. Heat a grill pan over medium-high heat. Cut eggplant stem off. Cut eggplant lengthwise into 1/4-inch-thick slices; brush with oil. Grill 7 minutes or until tender, turning once.
4. Combine peanut butter, onions, ginger, miso, and juice in a bowl; stir well.
5. Hollow out top and bottom halves of bread, leaving a 1-inch-thick shell; reserve torn bread for another use. Place bread on a baking sheet, cut sides up. Bake at 375° for 5 minutes or until golden brown. Spread bottom half of bread with peanut butter mixture. Arrange eggplant evenly over peanut butter mixture. Arrange carrot mixture and cucumber evenly over eggplant; top with cilantro and jalapeño, if desired. Place top half of bread on sandwich. Cut into 5 equal pieces.
MyRecipes is working with Let's Move!, the Partnership for a Healthier America, and USDA's MyPlate to give anyone looking for healthier options access to a trove of recipes that will help them create healthy, tasty plates. For more information about creating a healthy plate, visit www.choosemyplate.gov.
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Grilled Eggplant Banh Mi Sandwich Recipe


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Tags pop, jazz, electronic
Genres jazz, 60s, oldies, pop, folk (beta) (flag as incorrect)
Published February 09, 2010
Ten tracks to begin life.
Songs to go to sleep to by louclaudio
Ten tracks to go to sleep to : a lullaby playlist.
pop, classic rock, musiques de films
YOU you by louclaudio
a love letter in thirty-three tunes.
rock, oldies pop, pop/rock
songs for this morning by louclaudio
Eight tracks including music by Aaron Neville, Duffy and Elliott Smith.
tsururadio, rock, indie rock
Lyrics go like this by louclaudio
Eight tracks including three random ones at the end.
soul, oldies, rock


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Kingston and PNY Caught Bait-and-Switching Cheaper Components After Good Reviews
Re:And another on the ban pile (289 comments)
The company will (temporarily) make some extra profit, which is good for management bonuses. And after a few years the manager moves to another company... Rinse, repeat!
Another option is that it is just a manufacturing hack (because of component shortage) without properly thinking about the consequences.