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Actress Raven Goodwin and Singer Kenny Lattimore Come Home to DC to ... PR Web (press release) Actress Raven Goodwin is a DC native who found success on the hit television sitcom, Good Luck Charlie and her star continues to shine on the current BET smash drama, Being Mary Jane. Singer Kenny Lattimore, also a DC native is a veteran singing ... |
Yareah Magazine | Famous Birthdays Today, June 24: Lionel Messi, Solange Knowles, Minka Kelly ... Yareah Magazine More famous birthdays today, June 23: Minka Kelly, beautiful actress born in California in 1980; JJ Redick, basketball player born in Tennessee in 1984, who played for the Orlando Magic, the Milwaukee Bucks and the Los Angeles Clippers; Raven Goodwin, ... |
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Tim Thomas named NHL's First Star of the Week | 01.24.11 at 12:34 pm ET |
The NHL announced Monday that Bruins goaltender Tim Thomas has been named the First Star of the Week for the week ending on Jan. 22. Thomas went 3-0-0 over three starts last week, recording a shutout against the Hurricanes Monday and following it with a season-high 43-save effort on Monday. He made 32 saves in the team's 3-2 win over the Avalanche on Saturday.
Thomas, who will play in this weekend's All-Star Game, leads the NHL in goals against average (1.83), save percentage (.945), and his tied with Rangers netminder Henrik Lundqvist for the league lead with seven shutouts. He is second in wins with 23.
This is the fourth time this season a Bruins player has received a "Star" distinction. Thomas was the First Star of the Week for the week ending on Oct. 31 and was October's Second Star of the Month. Patrice Bergeron was named Second Star of the Week for the week ending on Jan. 15.
Bruins recall Matt Bartkowski on emergency basis | 01.14.11 at 10:21 am ET |
The Bruins announced Friday morning that they have recalled defenseman Matt Bartkowski from Providence on an emergency basis. The news comes after Andrew Ference left Thursday night's game with an injury after the second period.
Bartkowski was called up on an emergency basis on Sunday and made his NHL debut against the Penguins on Monday. He was returned to Providence after Adam McQuaid made his return to the lineup on Tuesday. The B's face the Penguins at home on Saturday.
Patrice Bergeron scores, but Flyers lead Bruins, 3-2, after two | 01.13.11 at 8:41 pm ET |
The Bruins got it done early on in the second period, but the Flyers finished the period stronger and take a 3-2 period into the third.
Patrice Bergeron scored his sixth goal in his last four games when he redirected a Steven Kampfer shot from the point past Brian Boucher just 45 seconds into the period. The Bruins continued their offensive pressure early on the period, with Boucher coming up big for the Flyers.
A turnover caused by Zdeno Chara led to Nikolay Zherdev's 14th goal of the season. Chara's shot was blocked and sent up ahead to Zherdev in the neutral zone, and the Russian winger tied it up on a breakaway. Jeff Carter made it 3-2 with 36 seconds left in the period.
Tim Thomas made 10 saves for the B's in the the second, most notably making a huge stop on a Scott Hartnell breakaway in halfway through the period. He was also the beneficiary of a couple of pucks clanking off posts.
Milbury on D&H: Patrice Bergeron didn't score three goals | 01.12.11 at 2:05 pm ET |
Mike Milbury of NESN, NBC Sports, and Hockey Night in Canada made his weekly appearance on Dale & Holley on Wednesday, discussing all things Bruins and his feelings on the NHL All-Star game.
Milbury was quite direct in speaking about Patrice Bergeron's first career hat trick, which he scored in Tuesday's 6-0 win over the Senators. Blake Wheeler appeared to have scored what was ruled Bergeron's second goal, and Milbury wasn't happy with how it was credited.
"The guys that do the scoring have the responsibility to get it right. They have to do everything to get it right. Do they fudge a little on [an assist] once in a while? I bet they do, and I think that's OK, but they've got to be honest and true to it," Milbury said. "Somebody's got to tell me there's a different angle that showed Bergeron scoring the goal, because I watched it several times, and pretty clearly, Blake Wheeler with a backhand [scored]. '¦ I didn't think there was any question whose goal that was."
Milbury said that given the fans throwing their hats twice — Brad Marchand's second-period goal was initially credited to Bergeron, which at the time would have been his third goal of the game — the Bruins and Bergeron are better off leaving the matter alone rather than giving Wheeler his due credit.
"It would be tough to do that after the three or four times they showered him with hats," Milbury said, adding that Bergeron should just "take the damn hat trick."
As for the state of the Bruins, who have been a Jekyll and Hyde team all season with their ups and downs, Milbury said it's difficult to gauge what type of team the Bruins are given their inconsistent nature. The Bruins have won their last two games after blowing a 2-0 lead in a 3-2 overtime loss to the rival Canadiens on Saturday.
"This is a hard team to pin down right now. I'm trying to figure out, what are they? '¦ I'd just like to see this team hit on all cylinders so I can figure out how good they are," Milbury said. "Now, they're a good team, not a great team. They're going to have to rely on some great goaltending and solid defense. '¦ I'm still not sure just how good this group is."
Since returning from post-concussion syndrome, center Marc Savard, who is in the first year of a seven-year deal, has struggled to regain the form that made him one of the league's elite playmakers. He has made costly mistakes and has been benched by Claude Julien in multiple situations. Milbury said the Bruins will need him to get back to where he was for the team to be competitive late in the season and in the playoffs.
"It's going to be critical to their success to have Savard finding the way back to his game," Milbury said. "Most guys who have injuries of big magnitude, of some sort of significance, take a long time. '¦ Hopefully by the end of the year, Savard will have found his rhythm and they find the right match for him with linemates."
Milbury has been one of Nathan Horton's biggest critics since the Bruins acquired the forward from the Panthers over the summer. He said that Horton's play "troubles" him, and that he's unsure of why the talented winger is so prone to disappearing in games.
"I don't know if it's focus, or if it's his level of competitiveness, but this guy form a tools standpoint has a hell of a lot more to offer on a regular basis," Milbury said.
"You have got to be involved. You've got to be involved on the forecheck, and hopefully you're involved in the physical side. He's not afraid, but it doesn't come naturally to him."
With Tim Thomas and Zdeno Chara both being named to the All-Star game, Milbury criticized the weekend for being "silly" and wondered whether the players would rather have the time off.
"Think of the players. They don't want to be there," Milbury said. "Except for the guys that just got named to their first or second All-Star team and want to be in the elite group — I can understand what an honor that's got to be — but once you're through that thrill, if it's not in your city, it's got to be [tiring].
"They're going to be escorted around all these nonsensical events '¦ and then play a half-assed game, and then they'll go home tired," he added. "Good idea."
Milbury's dislike for the All-Star festivities wasn't limited to the NHL. He said he feels the same way about the Pro Bowl and All-Star games of the MLB and NBA.
"I know it's a celebration of the sport, but for me it's not celebrating the sport. It's denigrating the sport."
Patrice Bergeron, Brad Marchand, Tyler Seguin score for Bruins in second period | 01.11.11 at 8:42 pm ET |
The Bruins opened up a 5-0 goal lead in the second period with some scoring, some fighting, and hundreds of hats thrown prematurely.
Patrice Bergeron, Brad Marchand, and Tyler Seguin all scored in the period. Bergeron's second goal of the game came when he banged one past Brian Elliot point-blank at 2:50. He was believed to have recorded the third goal of his perceived hat trick at 14:07, but after fans showered the ice with hats and the play was reviewed, it was determined that the puck went off Sergei Gonchar's skate and it was credited to Marchand. Seguin picked up his seventh goal of the season just over a minute later.
The period also featured a couple of fights. Nathan Horton dropped the gloves with Jesse Winchester and the two seemed to still have words from each others' respective penalty box. Shawn Thornton went with Matt Carnker at 10:26.
Andrew Ference has the only minor penalty of the period, and through two periods, the Bruins have not had a power play. The Bruins are outshooting Ottawa, 27-22. The shutout remains intact for Tim Thomas.
Adam McQuaid returns to Bruins lineup | 01.11.11 at 6:59 pm ET |
Defenseman Adam McQuaid will make his return to the Bruins lineup in Tuesday night's game against the Senators. McQuaid was considered a game-time decision after missing Monday's game in Pittsburgh with an undisclosed injury.
With McQuaid back in the lineup for the B's, rookie Matt Bartkowski, who made his NHL debut on Monday, will be a scratch.
Zdeno Chara, Tim Thomas named All-Stars | 01.11.11 at 2:11 pm ET |
Zdeno Chara and Tim Thomas were named to the 2011 NHL All-Star Game roster on Tuesday, the fifth selection for Chara and third for Thomas.
Chara is third in the NHL in average time on ice per game (26:38) and leads all Bruins' defenseman in goals (six) and points (18). Thomas leads the NHL in goals against average (1.84), save percentage (.944) and is tied for the league lead in shutouts (five).
Tyler Seguin will be one of 12 NHL rookies to participate in the SuperSkills competition. The All-Star Game will be played on Sunday, January 30 in Raleigh, NC.
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subset: commoncrawl


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Recent and archived news stories on: Apartments, Architecture, Brokers, Construction, Housing, Mortgages, Offices, Property Management, Realtors...Popchips to Move Headquarters to Los Angeles
San Francisco snack food manufacturer Popchips Inc. will move its headquarters to Playa Vista next month.
USC Embarks on Major Expansion
With the demolition of its outdated University Village complete, USC was expected to formally break ground Monday on the $650 million first phase of its $1.1 billion two-phase master-planned Village at USC.
Carwash Buyer Arrested for Money-Laundering
A downtown L.A. investor who recently purchased a prominent South Park development site was among those arrested last week when federal agents raided the Fashion District in connection with an alleged money-laundering scheme for international drug cartels.
Foreclosures and Home Sales Fall
Even as foreclosures fell to more normal levels, home sales in Southern California slipped to a four-year low in August as would-be buyers faced inventory and affordability challenges, according to separate reports released Thursday.
Los Angeles Real Estate More Valuable Than Ever
The value of the taxable property in city of Los Angeles rose by 6 percent over last year's figure, according to the 2014 Annual Report released on Wednesday by the Los Angeles County Office of the Assessor. The assessed values are the foundation of the property tax system and are used to divvy up tax revenue.
Disney Store Headquarters in Pasadena Acquired
The Pasadena building housing the world headquarters of Disney Stores USA has been acquired by Swig Co., a San Francisco real estate investment firm, it was announced Tuesday.
Retro Draw
If you're a fan of AMC's "Mad Men," then you've probably seen actor Jon Hamm lounging in sleek midcentury modern office furniture while sipping a stiff drink as his iconic character, Don Draper.
Sunkist Moving to Santa Clarita
More than a year after selling its landmark Sherman Oaks office building, Sunkist Growers Inc. announced Tuesday it will begin moving to its new home in Santa Clarita in September.
Golf Course Withdraws Application for 166-Foot Fence
The Los Angeles Country Club has withdrawn its application for a 166-foot fence to keep errant golf balls from straying onto a proposed development next door.
Chinese Developer Buys Robinsons-May Site
China's largest commercial developer has purchased the former Robinsons-May site in Beverly Hills, one of the most prominent retail locations in the Los Angeles area.
Chinese Investment Group Buys South Park Hotel
Shenzhen Hazens Real Estate Group Co., one of the largest development companies in China, has purchased the Luxe City Center Hotel and two adjacent parcels for $105 million.
SpaceX Headquarters Sold for Nearly $47 Million
A New Jersey real estate investment trust announced today that it has purchased the Hawthorne headquarters building of Elon Musk's Space Exploration Technologies Corp., also known as SpaceX, for $46.7 million.
CBRE Group Buys Australian Firm
CBRE Group Inc. of Los Angeles bought Paragon Project Management for an undisclosed price, the company announced Thursday.
TrueCar Inc. Moving to New Santa Monica Offices
Online car sales platform TrueCar Inc. announced that it will move its headquarters to 1401 Ocean Ave. from 120 Broadway, expanding its Santa Monica headquarters presence.
Upscale Co-Working Space NeueHouse Leases at Columbia Square
West L.A. real estate company Kilroy Realty Corp. said today that NeueHouse, New York's stylish members-only coworking space, signed a 15-year lease for 93,000 square feet at Columbia Square, a $400 million mixed-use project in Hollywood on the site of a former CBS broadcast studio.


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Steakhouse-Inspired Brasserie. Full Service Butcher Shop. Neighborhood Bar.
We accept reservations for parties of any size. These are taken on a first come, first served basis. Inquire by following the link to reservations or by calling the restaurant after 11:00AM.
Enjoy a drink or browse the butcher case while you wait. Walk-ins welcome in the bar! Please note:
"Part steakhouse, part butcher shop, 100 percent ode to all things meat - this is "The Year In Food" distilled into a single restaurant. All the good steakhouse cliches (fun, raucous) without all the bad ones (super-expensive, boys' club). - Andrew Knowlton


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Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
I come from a large Greek family and I learned how to cook at a very young age. I was always inspired watching my dad work his magic with garlic, lemon and olive oil and sitting at my papou's (grandpa) feet watching him make amazing soups. Today I take all those memories and recreate the dishes I grew up eating. It's funny that when you are a child you don't want to eat the dinner that mom and dad made and only want chicken nuggets- but once you are an adult you yearn for all those foods that you were gently force fed! I still try to get it just right and I think my dad would be proud with the legacy he left me!
Lamb, green beans, avacodos, fresh baked bread & mangos!


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| Email | Full Article (TrendHunter.com/id/177125) |
The Lupe Fiasco Vans OTW Stovepipe are kicks that you may not expect from the Grammy rapper who is well-versed in skater culture. Lupe Fiasco partnered with Vans beforehand creating a line of solid OTW minimalist sneakers. This time the rapper went with a little more pattern, mixing bright Native tribal patterns with a stark black background.
The footwear contains a canvas tongue, which holds most of the pattern. The rest of the dark exterior is crafted out of leather with a rubber midsole. The under sole is a bright golden yellow. The Lupe Fiasco Vans OTW Stovepipe shoes come with a drawstring backpack covered in the same eye-catching patterns found on the sneakers. When you open the solid black box they are packaged in, you'll be surprised with dizzying tribal print.


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Banks Optimistic on Economy Still Keep Cutting Expenses
NEW YORK (TheStreet) -- You could follow what banks say, or what they do. Or at least what they say they are going to do, which is cut expenses.
Cutting expenses is the theme that emerges from a review by Goldman Sachs financial services analysts of their most recent conference last week. The conference was held Tuesday and Wednesday and the latest report from Goldman (one of several they published on the conference) was published Monday.
"On the expense side, banks see opportunity to further reduce headcount and branches (albeit at a slower pace vs. 2013), and believe investments in technology, regulatory, and compliance costs should largely be in the run-rate by next year," Goldman's analysts wrote. "In terms of revenue improvements, commentary was more modest with banks noting they are managing what they can."
These phrases from Goldman's analysts offer a somewhat more bearish picture of the economy than the headlines (including our own) that came from CEO speeches.
Both Bank of America (BAC - Get Report) CEO Brian Moynihan and Wells Fargo (WFC - Get Report) CEO John Stumpf, for example, cited the mood of business banking clients in feeling more optimistic about the year ahead. Nonetheless, both CEOs said 2014 would be similar to 2013 in many respects. And much of their discussion of expenses, similar to that of JPMorgan Chase (JPM) CEO Jamie Dimon focused on legal and regulatory costs. Indeed, the bullish thesis on Bank of America for some time has been based on expense reduction, and Moynihan hewed closely to that theme in his comments last week. Moynihan said what Bank of America refers to as Legacy Asset Servicing expenses will go down by $1 billion per quarter next year as the bank lays off people it hired to address troubled home loans. Bank of America faced new scrutiny over its process for reviewing home loan modification requests Monday with the publication of a Bloomberg News story that focused on an outside contractor called Urban Lending. That contractor sent letters to troubled homeowners using stationary that said it came from the Office of the Bank of America CEO. However, the bank has already faced censures and fines from regulators as well as lawsuits for much, if not all of the activity described in the article, and the stock market shrugged off the report. Bank of America shares were up 0.92% to $15.32 in early trading Monday. Atlantic Equities analyst Richard Staite expects Bank of America 2014 non-interest expenses of $60.4 billion, down from an expected $67.8 billion in 2013. Revenue, meanwhile, will rise to $91.4 billion from $88.8 billion, according to Staite's forecasts. Staite has an "overweight" rating on Bank of America. As for Wells Fargo, Staite expects non-interest expenses of $47.7 billion for 2014, down slightly from his 2013 forecast of $48.5 billion. Staite sees revenue ticking up to $84.7 billion from $84.4 billion over the same time period. The analyst has an "underweight" rating on Wells Fargo. -- Written by Dan Freed in New York Follow @dan_freedCheck Out Our Best Services for Investors
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Tags alternative rock, remix, indie, dance
Genres hip hop, indie, rap, alternative, indie pop (beta) (flag as incorrect)
Published May 06, 2012
8 remix tracks. Original artists include Yeah Yeah Yeahs, Gotye, and The Xx. More tracks to come.
Cold by Zoe1218
winter, sleep, sad, cold
Go Hard or Go Home by Zoe1218
when the music hits you feel no pain.
edm, house, dance, pregame, party
Falling Leaves and Firesides: Fall 2012 by Zoe1218
fall, indie, folk, sleep, study
That Obligatory Fall Mix by Zoe1218
To be continued.
beautiful, sleep, fall, chill, calm


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Sleep deprived thanks to the 40 hour broadcast. I've stayed up way too late the last couple of nights watching it and it's made me want to be one of the Box People! Today's Wednesday! :thumbs:
I think I've got my Profile taken care of, now if I could only find the links to the 40 hour shows. I woke up this morning and couldn't find them on the site. Could that be a blessing in disguise? Might I actually get something done today?
Glad to be here, folks!


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Whether you're inside Mackinaws Grill & Spirits or just out in the natural world, "Do Not Feed the Bears" should be an easy lesson to get behind. / Corey Wilson/Press-Gazette photo
• Where: 2925 Voyager Drive, Green Bay
• Phone: (920) 406-8000
• Online: www.mackinaws.com
• Hours: 11 a.m.-10 p.m. Sunday-Saturday, 9 a.m.-2 p.m. Sunday brunch
Kevin Quinn was settled in Seattle. Had a great information technology gig, an even better girlfriend. Still refers to the area as Gods country thanks to all that fresh seafood and gorgeous scenery.
But a fairly innocuous family conversation at a ski chalet out West brought him back home.
With his dad Pat, a longtime restaurateur at Green Bay establishments like Gippers Sports Bar, BrewBakers Pub and Oxfords Cafe, out from each and free to pursue retirement, boredom inevitably kicked in. Surrounded by wood walls and a cozy campfire vibe, Kevins brother Ryan looked around and offered a common sense proposal.
Dad, what about opening a restaurant with a log cabin theme?
January officially marked 10 years at Mackinaws Grill & Spirits, Pat and Kevins 10,000 square-foot rustic-meets-casual restaurant that doubles as an outdoorsmans paradise on Green Bays east side. There have been the requisite menu changes and expected advancements in service and production. But overall, not much as changed from the vision of that first day.
In fact, whenever Kevin runs his hand over the wood walls, he still feels a supreme sense of accomplishment having helped harvest roughly 220 Norway Spruce trees planted on the Quinn family farm when Pat was a child for the restaurants interior.
This never goes out of style, Kevin said, tapping on the wood. People always like coming in and seeing a log cabin. Especially for this part of the state, this part of the country. That up north, woodsy feel puts you in a nice state of mind. Its cozy, its comfort, its a vacation.
Yet having grown up in the restaurant business pulling shifts as a dishwasher, waiter, bartender, you name it Kevin said he was ready to step into something new post-college. An IT recruitment job in Chicago led to a promotion in Seattle, where Kevin and his now-wife figured theyd be set.
But something about that log cabin idea stuck. The opportunity to work with his dad again, to eventually own a business in the city he grew up in, felt too perfect to pass up.
To start it from the ground up and see how its done, to get that direct knowledge by working with a guy who had done it a number of times
yeah, I was leaving a comfortable position and taking a risk, but I felt better knowing I was in it with my dad, Kevin said. There was a real security there knowing that we had it in our control.
Likewise for Pat, working with his son meant reaching back to the sidelines during Kevins soccer days. Pat talks like the quintessential coach, his emphasis on teamwork and communication essential to the growth of Mackinaws. As planned, Kevin has since assumed majority ownership Always be my dad. Im the boss, but he still tells me what to do, he jokes while Pat plays to his strengths with community involvement and customer rounds.
Its a special partnership that has yielded impressive results. On any given night, cars spill onto Voyager Drive trying to find a place to park, Mackinaws neon immediate seating sign rarely given a chance to light up for incoming East Mason Street traffic. Specifically, Friday night fish fries and Sunday brunch have become the kind of weekly staples local restaurateurs dream about.
A decade in, whats the secret? Wouldnt other restaurants in Green Bay like to know
Im not a food expert. Neither is my dad, Kevin said. But what we do know is that you have to complement your interior, and that your style of place has to develop a good, strong relationship with people in the community. So from the start, we had to make sure that our log cabin theme and all those animal mounts on the wall were paired with a nice, big bowl of elk stroganoff. Same with our fish. Pan fried walleye, perch, Lake Superior whitefish: our core had to be those regional specific items that fit our theme. Thats what connects.
I think its the appreciation of seeing the owners here. The quality of the product and the consistency of the product, Pat added. Plus, people want to be recognized and appreciated. They want to be treated special. I think our staff does that. I know our staff does that.
Food wise, Mackinaws aims for variety with its selection of seafood, steaks, pastas, burgers, sandwiches and even Mexican dishes. Getting too big and too diverse sometimes allows the menu to get away from a restaurant, Kevin said. That was somewhat true at the outset, when as part of their wild kingdom décor mountain lions, caribou and bears, oh my! Mackinaws initiated a weekly wild game night, some of which became too exotic and expensive. Eventually, Kevin learned to stick with what endures buffalo and elk, for instance while offering enough variety to keep customers coming in for different entrees multiple times a week.
Couple that with a loyalty program aimed at rewarding regulars, and comfort food favorites like scratch soups, Saturday night BBQ ribs or just a gooey basket of cheese curds have kept business swinging mightier than Paul Bunyans axe. Those six fireplaces dont hurt in winter, either.
Get inside a log cabin with a roaring fire and you can envision eating steaks, envision eating perch and finishing it all off with a big pint of beer, Kevin said. That was our idea at the start, and weve kept an open mind to everything else as more ideas have poured in. Weve never taken our place in the community for granted.
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Publications (17)63.78 Total impact
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ABSTRACT: Background: The prognostic implications of the diagnosis of a papillary thyroid carcinoma (PTC) with tall cell features (TCF) are unknown. Methods: All PTC patients identified between 1985 and 2005 were analyzed histologically. Classical PTC (cPTC) were defined as having <30% tall cells, PTC TCF (30-49% tall cells), tall cell variant (TCV) (>50% tall cells). All cPTC, PTC TCF and TCV > 1 cm in size were included. Results: 453 patients satisfied the inclusion criteria (288 cPTC, 31 PTC TCF and 134 TCV). cPTC patients were younger than their PTC TCF and TCV counterparts (p<0.0002). There was an increase in tumor size from cPTC to PTC TCF and TCV (p=0.05). Extensive extra-thyroid extension and positive margins were more often present in TCV and PTC TCF than in cPTC . (p=0.0001, 0.03 respectively). Overall pathologic tumor (pT) stage was more advanced in TCV and PTC TCF than in cPTC (p<0.0001). Total thyroidectomy and radioactive iodine therapy were more often performed and administered on TCV patients than on their PTC TCF and cPTC counterparts (p=0.001, p=0.0001 respectively). Median follow up was 9.3 years. 10 year disease specific survival (DSS) was lower in TCV (96%) and PTC TCF (91%) than in cPTC (100%) (p<0.001). 10 year distant recurrence free (RFS) survival was higher in cPTC (98%) than in PTC TCF (89%) and TCV (96%) (p=0.03). In multivariate analysis, the presence of >5 positive nodes and extra-nodal extension were the only independent prognostic factors of neck and distant RFS respectively. Four (2.4%) of 165 PTC with TCF and PTC TCV developed poorly differentiated or anaplastic carcinoma in their recurrence while none of 288 classical PTC transformed into higher grades (p=0.017). Conclusions: 1) PTC TCF and TCV have similar clinico-pathologic features that are more aggressive than cPTC 2) PTC TCF and TCV have similar DSS and distant RFS but poorer than cPTC 3) PTC TCF are currently being treated like cPTC less aggressively than TCV 4) PTC TCF and PTC TCV have a higher rate of high grade transformation than cPTC. 5) Consideration should be given to use a 30% tall cells threshold to diagnose TCV.Thyroid: official journal of the American Thyroid Association 11/2013; · 2.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background: There continues to be controversy regarding what clinico-pathological features confer a higher risk of adverse outcome in papillary microcarcinomas (PMC). The aim of this study is to assess the prognostic values of a meticulous histologic examination in PMC. Methods: All papillary thyroid carcinoma (PTC) <1 cm in size without associated larger thyroid carcinomas (TC), identified between 1977 and 2002, were categorized as PMC and subjected to a meticulous histopathologic examination by 2 thyroid pathologists. Results: 148 PMC fulfilled the inclusion criteria. Within PMC, young age, male sex, tumor multicentricity, extrathyroidal extension, infiltrative and larger tumor (> 0.5 cm) correlated with the presence of >1 cm metastatic node (MN) or >3 MN at presentation (p<0.05). With a median follow up (FU) of 9.9 years. only one (0.7%) of 134 PMC patients died of TC and 3 (2.2%) had recurrences in the neck. The patient who died harbored a poorly differentiated carcinoma (PDC) in his MN. The presence of MN and especially a large size MN (>1 cm) correlated with worse Recurrence free survival (RFS) (p=0.005, p<0.0001 respectively). Except for one, all individuals with clinically adverse outcomes had >1 cm MN. Patients whose MN were predominantly composed of PDC or tall cell variant PTC had a significant shorter RFS (p<0.0001). Only 1 of 80 radioactive iodine (RAI) naïve PMC patients with absent or small MN (<=1 cm) recurred with a median FU of 9.2 years. Conclusions: 1) The size and histotype of the MN are predictors of outcome in PMC and should be recorded. 2) The very rare PMC who recur or even die of disease have usually aggressive histopathologic features at presentation. 3) PMC with nodal disease that is small or absent at presentation are at very low risk of recurrence and may be spared RAI therapy.Thyroid: official journal of the American Thyroid Association 06/2013; · 2.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Papillary thyroid carcinoma (PTC) patients presenting with cervical lymph nodes (LN) metastases (M) have a variable outcome. The objective of this study is to assess the value of meticulous histopathologic examination and genotyping in stratifying these patients into clinically relevant prognostic subgroups. This was a retrospective clinical and histopathological review of PTC patients with lymph node metastases at presentation identified between 1980 and 2002 in a single institution. Primary tumors from patients who later recurred were matched to a group of patients who did not recur and subjected to mass spectrometry genotyping encompassing the most significant oncogenes in thyroid carcinomas. There were 246 patients who satisfied the inclusion criteria. The median follow-up was 10.8 years. The presence of >3 metastatic nodes was an independent predictor of decreased recurrence free survival (p=0.03). In patients <45 years, none of 45 with 1-2 metastatic LN recurred, including 26 patients followed for a median of 13 years without radioactive iodine (RAI) therapy. BRAF mutations were found in 28 (78%) of 36 genotyped tumors. Combined positivity for BRAF and extra-nodal extension was much stronger in predicting disease specific survival (DSS) (p=0.004) than the single analysis of BRAF (p=0.12) or extra-nodal extension (p=0.02). (i) The number of metastatic LN is an independent predictor of recurrence in all age groups and identifies a subset of young patients with excellent prognosis who may not benefit from RAI therapy. (ii) Combined positivity for BRAF and extra-nodal extension has additive prognostic value in predicting DSS. (iii) Classification systems that assign the same magnitude of risk for recurrence or death to all patients with N1 disease should be revisited.Thyroid: official journal of the American Thyroid Association 04/2012; 22(6):575-84. · 2.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background: Papillary thyroid carcinoma (PTC) patients presenting with cervical lymph nodes (LN) metastasis (M) have a variable outcome. The objective of this study is to assess the value of meticulous histopathologic examination and genotyping in stratifying these patients into clinically relevant prognostic subgroups. Methods: Retrospective clinical and histopathological review of PTC patients with LNM at presentation identified between 1980 and 2002 in a single institution. Primary tumors from patients who later recurred were matched to a group of patients who did not recur and subjected to mass spectrometry genotyping encompassing the most significant oncogenes in thyroid carcinomas. Results: 246 patients satisfied the inclusion criteria. Median follow up was 10.8 years. The presence of >3 metastatic nodes was an independent predictor of decreased recurrence free survival (p=0.03). In patients < 45 years, none of 45 cases with 1-2 metastatic LN recurred, including 26 patients followed for a median of 13 years without radioactive iodine (RAI) therapy. BRAF mutations were found in 28 (78%) of 36 genotyped tumors. Combined positivity for BRAF and extra-nodal extension was much stronger in predicting disease specific survival (DSS) (p=0.004) than the single analysis of BRAF (p=0.12) or extra-nodal extension (p=0.02). Conclusions: 1) The number of metastatic LN is an independent predictor of recurrence in all age groups and identifies a subset of young patients with excellent prognosis who may not benefit from RAI therapy. 2) Combined positivity for BRAF and extra-nodal extension has additive prognostic value in predicting DSS. 3) Classification systems that assign the same magnitude of risk for recurrence or death to all patients with N1 disease should be revisited.Thyroid: official journal of the American Thyroid Association 12/2011; · 2.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Anaplastic thyroid carcinoma (ATC) is a rare, aggressive malignancy. The potential for pathologic misclassification complicates interpretation of published data. One standard treatment option for locoregionally advanced disease is weekly low-dose doxorubicin with concurrent radiation therapy, and was previously developed at our institution. We evaluated our more recent experience with this approach, which included pathologic confirmation of all cases. A retrospective review was performed on patients identified through the Memorial Sloan-Kettering Cancer Center (MSKCC) Cancer Database. Inclusion criteria: pathologically confirmed ATC; locoregional disease encompassable within a radiation portal; treatment with curative intent at MSKCC with planned weekly doxorubicin (10 mg/m(2)) and concurrent radiation. Principle outcomes assessed were locoregional progression-free survival (LR-PFS) and overall survival (OS). Thirty-seven patients were included. Median radiotherapy dose was 57.6 Gy, and was ≥ 50Gy in 29 (78%), administered through hyperfractionated or once-daily schedules. One-year outcomes were LR-PFS, 45%; OS, 28%. The prognosis of patients with ATC remains grim and our current results appear inferior to those reported previously by our institution. More accurate histologic diagnoses and patient selection in the present series compared to the prior one may be responsible in part. Better therapy is desperately needed for this aggressive disease.Radiotherapy and Oncology 12/2011; 101(3):425-30. · 4.86 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The impact of varying degrees of extrathyroid extension (ETE), especially microscopic ETE (METE), on survival in thyroid carcinomas (TC) has not been well established. Our objective was to analyze ETE at the molecular and histologic levels and assess the effect of its extent on outcome. All cases of TC with ETE but without nodal metastases at presentation (NMP) were identified over a 20-year period and grouped into gross and METE. Twelve papillary thyroid carcinomas (PTCs) without ETE and NMP were also analyzed. Cases with paraffin tissues were subjected to mass spectrometry genotyping encompassing the most significant oncogenes in TC: 111 mutations in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, and AKT1, and other related genes were surveyed. Eighty-one (10%) of 829 patients in the database had ETE and no NMP. There was a much higher frequency of poorly differentiated and anaplastic carcinomas (12/29, 41%) in patients with gross ETE than in those with METE (3/52, 6%) (p < 0.01). There was a higher disease-specific survival (DSS) in patients with METE than in those with gross ETE (p < 0.0001). Except for an anaplastic case, no recurrences were detected in 45 patients with METE, including 23 PTC patients followed up for a median of 10 years without radioactive iodine therapy. Within patients with gross invasion into trachea/esophagus, tumors with high mitotic activity and/or tumor necrosis correlated with worse DSS (p < 0.05). Fifty-six cases with ETE were genotyped as follows: BRAFV600E, 39 (70%); BRAFV600E-AKT1, 1 (1.8%); NRAS, 1 (1.8%); KRAS, 1 (1.8%); RET/PTC, 3 (5%); wild type, 11 (19.6%). Within PTCs, BRAF positivity rate increased the risk of ETE (p = 0.01). If PTC follicular variants are excluded, BRAF positivity does not correlate with ETE status within classical/tall cell PTC. (i) PTCs with METE without NMP have an extremely low recurrence rate in contrast to tumors with gross ETE. (ii) High mitotic activity and/or tumor necrosis confers worse DSS even in patients stratified for gross ETE in trachea/esophagus. (iii) BRAF positivity correlates with the presence of ETE in PTC, but this relationship is lost within classical/tall cell PTC if follicular variants are excluded from the analysis.Thyroid: official journal of the American Thyroid Association 10/2010; 20(10):1085-93. · 2.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The follicular variant of papillary thyroid carcinoma usually presents as an encapsulated tumor and less commonly as a partially/non-encapsulated infiltrative neoplasm. The encapsulated form rarely metastasizes to lymph node, whereas infiltrative tumor often harbors nodal metastases. The molecular profile of the follicular variant was shown to be close to the follicular adenoma/carcinoma group of tumors with a high RAS and very low BRAF mutation rates. A comprehensive survey of oncogenic mutations in the follicular variant of papillary thyroid carcinoma according to its encapsulated and infiltrative forms has not been performed. Paraffin tissue from 28 patients with encapsulated and 19 with infiltrative follicular variant were subjected to mass spectrometry genotyping encompassing the most significant oncogenes in thyroid carcinomas: 111 mutations in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, AKT1 and other related genes. There was no difference in age, gender, tumor size and angioinvasion between encapsulated or infiltrative tumors. Infiltrative carcinomas had a much higher frequency of extrathyroid extension, positive margins and nodal metastases than encapsulated tumors (P<0.05). The BRAF 1799T>A mutation was found in 5 of 19 (26%) of the infiltrative tumor and in none of the encapsulated carcinomas (P=0.007). In contrast, RAS mutations were observed in 10 of 28 (36%) of the encapsulated group (5 NRAS_Q61R, 3 HRAS_Q61, 1 HRAS_G13C and 1 KRAS_Q61R) and in only 2 of 19 (10%) of infiltrative tumors (P=0.09). One encapsulated carcinoma showed a PAX8/PPARgamma rearrangement, whereas two infiltrative tumors harbored RET/PTC fusions. Encapsulated follicular variant of papillary thyroid carcinomas have a molecular profile very close to follicular adenomas/carcinomas (high rate of RAS and absence of BRAF mutations). Infiltrative follicular variant has an opposite molecular profile closer to classical papillary thyroid carcinoma than to follicular adenoma/carcinoma (BRAF>RAS mutations). The molecular profile of encapsulated and infiltrative follicular variant parallels their biological behavior (ie, metastatic nodal and invasive patterns).Modern Pathology 09/2010; 23(9):1191-200. · 6.36 Impact Factor -
Article: Anaplastic thyroid carcinoma: morphologic findings and PAX-8 expression in cytology specimens.
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ABSTRACT: To evaluate the morphologic findings most encountered in anaplastic thyroid carcinomas (ATCs) and evaluate for the expression of PAX-8. The cytology specimens from 21 cases of ATC were evaluated for the following several cytologic criteria: cell morphology, pleomorphism, presence or absence of multinucleated cells, colloid, neutrophilic infiltrate and well-differentiated component. Immunohistochemical studies for PAX-8 were performed on cell blocks in selected cases. The most common morphology present was epithelioid, followed by spindle, multinucleated giant cell and rhabdoid, with 75% demonstrating more than 1 cell morphology. Marked pleomorphism (81%), neutrophilic infiltrate (90%) and necrosis (63%) were frequent. No nuclear grooves, colloid or well-differentiated component was identified in any case. Immunocytochemical stains for PAX-8 were negative in 5 cases in which a cell block was available. ATC is a tumor with diverse morphologic characteristics, and more than 1 cell morphology is usually present. A neutrophilic infiltrate is a common finding and represents a clue to the correct diagnosis.Acta cytologica 01/2010; 54(5):668-72. · 1.56 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming from their rarity, low-stage, high-grade appearance, and lack of long-term follow-up studies. All cases of EFHG were defined as encapsulated tumors of follicular cell origin with at least 5 mitoses per 10 high-power fields and/or tumor necrosis. Available tissues were subjected to a thyroid carcinoma platform for mass spectrometry high-throughput genotyping, which consisted of 111 known mutations in 16 different genes: BRAF, RET, NRAS, HRAS, KRAS, PIK3CA, AKT1, and other related genes. Twenty-five cases met the selection criteria. Tumor necrosis was present in 56.0% (n = 14). Extensive vascular invasion was identified in 24.0% (n = 6). Eight (32%) of 25 tumors were noninvasive. Twenty-two patients (88%) were free of disease (median follow up: 8.5 years). All 8 noninvasive tumor did not recur despite focal/extensive tumor necrosis in 3 cases and a median follow-up of 11.9 years. EFHG with no vascular invasion did not recur. In patients without distant metastases at presentation (n = 24), 33% (2/6) of patients with extensive angioinvasion relapsed, whereas none of 18 with absent/focal vascular invasion recurred (P = .054). Mutations were found in 10 (45%) of 22 cases tested: 8 had NRAS codon 61, 1 KRAS codon 61, and 1 had coexistent BRAF V600E and AKT1. There was a higher frequency of RAS (9/22, 41%) than BRAF mutations (1/22, 4.5%) (P = .009). Noninvasive EFHG have an indolent behavior even in the presence of extensive tumor necrosis. EFHG with absent vascular invasion have an excellent prognosis despite the frequent occurrence of tumor necrosis. NRAS mutations are the most frequent oncogenic event in EFHG.Human pathology 11/2009; 41(2):172-80. · 2.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC), and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality, particularly if positive on [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET). To obtain comprehensive genetic information on advanced thyroid cancers, we designed an assay panel for mass spectrometry genotyping encompassing the most significant oncogenes in this disease: 111 mutations in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, AKT1, and other related genes were surveyed in 31 cell lines, 52 primary tumors (34 PDTC and 18 ATC), and 55 RAIR, FDG-PET-positive recurrences and metastases (nodal and distant) from 42 patients. RAS mutations were more prevalent than BRAF (44 versus 12%; P = 0.002) in primary PDTC, whereas BRAF was more common than RAS (39 versus 13%; P = 0.04) in PET-positive metastatic PDTC. BRAF mutations were highly prevalent in ATC (44%) and in metastatic tumors from RAIR PTC patients (95%). Among patients with multiple metastases, 9 of 10 showed between-sample concordance for BRAF or RAS mutations. By contrast, 5 of 6 patients were discordant for mutations of PIK3CA or AKT1. AKT1_G49A was found in 9 specimens, exclusively in metastases. This is the first documentation of AKT1 mutation in thyroid cancer. Thus, RAIR, FDG-PET-positive metastases are enriched for BRAF mutations. If BRAF is mutated in the primary, it is likely that the metastases will harbor the defect. By contrast, absence of PIK3CA/AKT1 mutations in one specimen may not reflect the status at other sites because these mutations arise during progression, an important consideration for therapies directed at phosphoinositide 3-kinase effectors.Cancer Research 07/2009; 69(11):4885-93. · 9.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Struma ovarii (SO) infrequently harbor carcinomas that are histologically similar to those arising in the eutopic thyroid. We identified 10 such cases in our files. Eight patients presented with pelvic-related symptoms whereas 2 were incidentally discovered during pregnancy, all with disease confined to the ovary. There were 8 papillary thyroid carcinomas (PTCs) (2 classic and 6 follicular variant) and 2 poorly differentiated thyroid carcinomas. Two of the 10 thyroid carcinomas relapsed after an initial diagnosis of "benign" struma. Both occurred in young women with ovarian cysts discovered during pregnancy. The cystectomy from 1 patient showed thyroid follicles with nuclear features of the follicular variant of PTC whereas the cyst from the second patient showed thyroid follicles with subtle nuclear features, suggestive but not diagnostic of PTC. Both patients presented with disseminated PTC 3 and 4 years after the initial diagnosis, involving the pelvis in both cases and also the liver parenchyma in 1 case. The 2 patients received radioactive iodine therapy after thyroidectomy and are both alive with disease 6 years after diagnosis. The criteria separating hyperplastic nodules from well-differentiated follicular variant of PTC in the thyroid gland seem to be applicable to thyroid-type carcinomas arising in SO. The propensity for adverse clinical behavior does not seem to be related to the grade or histologic type of carcinoma in this small series. The hormonal milieu during pregnancy may lead to progression of malignant SO and such patients should be closely followed, particularly if their treatment consists of cystectomy alone.International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists 06/2009; 28(3):222-30. · 2.07 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Encapsulated papillary thyroid carcinoma (EPTC) can have a histologic growth pattern similar to the one seen in classical papillary thyroid carcinoma (PTC) or akin to the follicular variant of PTC (FVPTC). This study aims to assess the behavior of EPTC according to its growth pattern. All cases of thyroid carcinomas treated at our institution between 1980 and 2000 were reviewed and reclassified according to current histopathologic criteria. After review by two pathologists, 106 cases were included. Forty-three (41%) of the cases were identified as encapsulated classical PTC (E-CPTC) and 63 (59%) as encapsulated FVPTC (E-FVPTC). E-FVPTC had a higher rate of vascular invasion (16/63; 25%) than E-CPTC (2/43; 5%) (p = 0.007). In contrast, E-CPTC had a higher frequency of capsular invasion (28/43; 65%) than E-FVPTC (24/63, 38%) (p = 0.01). The lymph node metastatic rate was significantly higher in E-CPTC (11/43, 26%) compared to E-FVPTC (2/63, 3%) (p = 0.0014). All 34 noninvasive E-FVPTC lacked evidence of nodal metastases while 4 of 15 (27%) noninvasive E-CPTC presented with nodal disease (p = 0.006). Distant metastasis occurred only in four cases of E-FVPTC at presentation. These four FVPTC had extensive capsular and/or vascular invasion and no nodal disease. None of noninvasive EPTC recurred, including 30 patients treated by lobectomy without radioactive iodine (RAI) therapy (median follow-up: 8.9 years). E-CPTC resembles classical PTC in its propensity to metastasize to lymph nodes and its vascular/capsular invasive pattern while E-FVPTC behaves more like follicular carcinoma/adenoma group of tumors. Meticulous search for capsular and vascular invasion can reliably predict the metastatic potential of E-FVPTC but not of E-CPTC. The latter can therefore be treated like unencapsulated classical PTC. Noninvasive E-FVPTC could be managed like minimally invasive follicular carcinoma by lobectomy without RAI therapy. Invasive E-FVPTC seem quite indolent if no distant metastases are found at presentation.Thyroid: official journal of the American Thyroid Association 03/2009; 19(2):119-27. · 2.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: External beam radiotherapy (EBRT) plays a controversial role in the management of nonanaplastic thyroid cancer. We reviewed our institution's outcomes in patients treated with EBRT for advanced or recurrent nonanaplastic thyroid cancer. Between April 1989 and April 2006, 76 patients with nonanaplastic thyroid cancer were treated with EBRT. The median follow-up for the surviving patients was 35.3 months (range, 4.2-178.4). The lesions were primarily advanced and included Stage T2 in 5 (7%), T3 in 5 (7%), and T4 in 64 (84%) patients. Stage N1 disease was present in 60 patients (79%). Distant metastases before EBRT were identified in 27 patients (36%). The median total EBRT dose delivered was 6,300 cGy. The histologic features examined included medullary in 12 patients (16%) and nonmedullary in 64 (84%). Of the 76 patients, 71 (93%) had undergone surgery before RT, and radioactive iodine treatment was used in 56 patients (74%). The 2- and 4-year overall locoregional control rate for all histologic types was 86% and 72%, respectively, and the 2- and 4-year overall survival rate for all patients was 74% and 55%, respectively. No significant differences were found in locoregional control, overall survival, or distant metastases-free survival for patients with complete resection, microscopic residual disease, or gross residual disease. Grade 3 acute mucositis and dysphagia occurred in 14 (18%) and 24 (32%) patients, respectively. Late adverse toxicity was notable for percutaneous endoscopic gastrostomy tube use in 4 patients (5%). The results of our study have shown that EBRT is effective for locoregional control of selected locally advanced or recurrent nonanaplastic thyroid malignancies, with acceptable acute toxicity.International journal of radiation oncology, biology, physics 09/2008; 73(3):795-801. · 4.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Radioactive iodine-refractory (RAIR) 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) positive thyroid carcinomas represent the major cause of deaths from thyroid carcinomas (TC) and are therefore the main focus of novel target therapies. However, to the authors' knowledge, the histology of FDG-PET-positive RAIR metastatic thyroid carcinoma has not been described to date. Metastatic tissue from RAIR PET-positive patients identified between 1996 and 2003 at the study institution were selected for histologic examination. The biopsied metastatic site corresponded to a FDG-PET positive lesion sampled within 2 years (87% of which were sampled within 1 year) of the PET scan. Detailed microscopic examination was performed on the metastatic deposit and the available primary tumors. Poorly differentiated thyroid carcinomas (PDTC) were defined on the basis of high mitotic activity (> or =5 mitoses/10 high-power fields) and/or tumor necrosis. Other types of carcinomas were defined by conventional criteria. The histology of the metastases and primary were analyzed, with disease-specific survival (DSS) as the endpoint. A total of 70 patients satisfied the selection criteria, 43 of whom had primary tumors available for review. Histologic characterization of the metastasis/recurrence in 70 patients revealed that 47.1% (n = 33 patients) had PDTC, 20% (n = 14 patients) had the tall cell variant (TCV) of papillary thyroid carcinoma, 22.9% (n = 16 patients) had well-differentiated papillary thyroid carcinoma (WDPTC), 8.6% (n = 6 patients) had Hurthle cell carcinoma (HCC), and 1.4% (n = 1 patient) had anaplastic carcinomas. The histopathologic distribution of the tumor in the primaries was: PDTC, 51%; TCV, 19%; WDPTC, 23%; and widely invasive HCC, 7%. A differing histology between the primary tumor and metastasis was observed in 37% of cases (n = 16 patients). In the majority of instances (63%; 10 of 16 patients) this was noted as transformation to a higher grade. Of the primary tumors classified as PTC, 70% progressed to more aggressive histotypes in the metastasis. Tumor necrosis and extensive extrathyroid extension in the primary tumor were found to be independent predictors of poorer DSS in this group of patients (P = .015). Approximately 68% of the PDTC primary tumors were initially classified by the primary pathologist as better-differentiated tumors on the basis of the presence of papillary and/or follicular architecture or the presence of typical PTC nuclear features. Several observations can be made based on the results of the current study. The majority of metastases in patients with RAIR PET-positive metastases are of a histologically aggressive subtype. However, well-differentiated RAIR metastatic disease is observable. Poorly differentiated disease is underrecognized in many cases if defined by architectural and nuclear features alone. The presence of tumor necrosis was found to be a strong predictor of aggressive behavior, even within this group of clinically aggressive tumors. Finally, there is a significant amount of histologic plasticity between primary tumors and metastases that may reflect the genetic instability of these tumors.Cancer 07/2008; 113(1):48-56. · 4.90 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Renal tumors may arise in the setting of end-stage renal cell disease. The risk is 100 times that of the normal population with an incidence ranging from 3-7%. The most common malignant tumor to arise in the setting of acquired cystic disease of the kidney is the acquired cystic disease-associated renal cell carcinoma (ACD-associated RCC). The cytomorphologic features of ACD-associated RCC, which has not been described previously, show moderately cellular specimens composed of clusters of cells with papillary configuration. The cells ranged from polygonal to columnar and contained abundant eosinophilic granular cytoplasm. The nuclei were round and centrally located, and the chromatin was finely granular with prominent central nucleoli that corresponded to Fuhrman's grade 3 nucleolar size. The main differential diagnosis is type 2 papillary renal cell carcinoma, from which it can be distinguished based on clinical findings only at this moment.Diagnostic Cytopathology 06/2008; 36(5):344-7. · 1.52 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Thyroid-specific transcription factors, Pax8, TTF-1, and TTF-2, are crucial for thyroid organogenesis and differentiation. Compared with TTF-1, the other two markers have scarcely been investigated in surgical pathology. The goal of this study is to evaluate the expressions of these markers in thyroid tumors of the full spectrum of differentiation, with special emphasis on anaplastic carcinomas. A total of 94 cases of thyroid neoplasms were studied: 17 papillary carcinomas, 18 follicular adenomas, 16 follicular carcinomas, 7 poorly differentiated carcinomas, 28 anaplastic carcinomas, and 8 medullary carcinomas. Immunostains for these three markers were performed. The antibodies to Pax8 and TTF-2 were also applied on 147 lung carcinomas as well as a variety of normal tissues and malignant tumors. All three markers were seen in papillary carcinomas, follicular adenomas and carcinomas, and poorly differentiated carcinomas in a diffuse manner, whereas their expressions in medullary carcinomas were variable. Pax8 was expressed in 79% of anaplastic carcinomas to a variable extent, whereas TTF-1 and TTF-2 were seen only in 18 and 7% of anaplastic carcinomas, respectively. TTF-2 was negative in all other neoplastic and non-neoplastic tissues including those of the lung. Pax8 was expressed in renal tubules, fallopian tubes, ovarian inclusion cysts, and lymphoid follicles as well as renal carcinoma, nephroblastoma, seminoma, and ovarian carcinoma, but not in normal tissue and carcinomas of the lung. Pax8 is a useful marker for the diagnosis of anaplastic carcinomas, particularly when the differential diagnosis includes pulmonary carcinoma. In differentiated thyroid neoplasms, no significant difference in expression was seen in all the three transcription factors.Modern Pathology 03/2008; 21(2):192-200. · 6.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The tall cell variant (TCV) is a histologic subtype of papillary thyroid carcinoma (PTC) that is more aggressive than "classical" PTC. Most authors believe that TCV's worse prognosis is related to older age at presentation, larger tumor size, and high frequency of extrathyroid tumor extension (ETE). To assess the biologic and clinical behavior of TCV without ETE, we performed a detailed comparative clinicopathologic analysis of classical PTC and TCV without ETE. TCV was defined as a PTC harboring >50% tall cells, while classical PTC was restricted to those tumors containing >1% papillae and <30% tall cells. Microscopic analysis and chart review identified 62 cases of TCV and 83 classical PTC without ETE. These patients were analyzed for various pathologic, imaging, and clinical parameters including outcome. There was no statistical difference between TCV and classical PTC in relation to age, gender, tumor size, risk stratification, type of therapy, and length of follow-up. TCV displayed more invasion of the tumor capsule and more often infiltrated into the thyroid capsule (p = 0.047 and 0.0004, respectively). Among patients with microscopically assessable regional lymph node (LN), 33 of 49 (67.3%) patients with TCV had LN metastasis at presentation, while only 24 of 60 (40%) classical PTC had positive nodes (p = 0.004). In multivariate analysis, histologic subtype (TCV vs. classical PTC) was the only independent factor associated with LN metastases (p = 0.007). In patients with adequate follow-up, 4 of 62 (6.5%) classical PTC and 7 of the 47 (14.9%) TCV had thyroid cancer recurrence (p = 0.202). TCV recurred at a distant site (3 of 47, 6.4%) while none of the 62 classical PTC developed distant metastases (p = 0.077). TCV without ETE is biologically a more aggressive tumor than classical PTC without ETE independent of age, gender, and tumor size.Thyroid 07/2007; 17(7):655-61. · 3.84 Impact Factor
Publication Stats
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Memorial Sloan-Kettering Cancer Center
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New York University
- Department of Pathology
New York City, NY, United States


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Select () or exclude () categories to narrow your recipe search.
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"Great dessert! I skipped the grated coconut and used white sugar instead of brown. I garnished it with fresh strawberries."
"It doesn't taste like frosting, but it does add a creamy sweetness to your cake."
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"This is yummy and very easy to make. I needed it to be more spicy though. I added some Thai sweet chili sauce and that made it perfect. "
"A very good recipe that is easy to prepare! I used canned LaSeur peas instead of frozen. My SO thought the dish tasted great."
"I bought canned lychees and substituted soy milk for the milk. I didn't need to add any sugar b/c the lychee syrup is super sweet. This is a surprisingly good dessert."


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Seventeen is all about color and energy.
My advice to anyone who wants to be on the cover of Seventeen Magazine is take good care of yourself.
A girl that's really approachable makes a perfect Seventeen cover model.
Channel that little girl in you. Don't try to be anyone else but yourself and those moments that are captured are the best.
Seventeen girls, they're vivacious, they're youthful, they got some pizazz to them. Everybody has their own little secret and that's probably gonna have to like find and pull out.
In one word, I think a Seventeen cover star is energetic and full of life and effervescent.
That's three words.
For me, my favorite Seventeen covers have been of people that invoke a feeling inside of you, you don't get anywhere else and I think that when you get that perfect smile and that perfect style outfit and that beautiful hair and makeup, there is nothing like it. You could see the image without seeing Seventeen and you know it's Seventeen.
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Application deadline: | Start in 1 September: April (non-EEA: April). |
Tuition fee: | Visit Programme Website |
Start date: | September 2015 |
Credits (ECTS): | 120 ECTS |
Duration full-time: | 24 months |
Languages: |
Location: |
Delivery mode: | On Campus |
Educational variant: | Full-time |
More information: | Go to university website |
You just visited a programme website!
Do you want to know everything about the causes of disease? Are you very eager to explore public health in depth? Then Biomedical Sciences is your Master's programme.
The Master in Biomedical Sciences is a two-year full-time programme. You can take up to two specializations, each lasting one year. You can choose from seven Biomedical research specializations: Infectious Diseases; Cardiovascular Diseases; International Public Health; Immunology; Cell Biology; Psychophysiology; or Medical and Behavior Genomics. You can also choose one other specialization (combined with one research specialization): Societal; Communication; or Education. Are you interested in infectious diseases and do you want to gain a deeper understanding of how our immune system works? Then you can take both these specializations. Does your scientific interest lie in cardiovascular diseases and your professional ambition in policy-making? Again, you can combine the two. However, you can also compile your own programme.
Programme internationalization:
This programme has a workload of 120 ECTS.
(non research)
Infectious Diseases:
International Public Health:
(non research)
Medical and Behavior Genomics:
(non research)
Societal specialization:
(non research)
Education specialization:
(non research)
Communication specialization:
(non research)
Written request: motivation, cv and references
Language test
Additional subject
Previous education: BSc in biomedical sciences or equivalent
Grade list: transcript
Additional language requirements:
IELTS band: | 6.5 |
CAE score: (read more) Cambridge English: Advanced (CAE) is part of the Cambridge English suite and is targeted at a high level (IELTS 6.5-8.0). It is an international English language exam set at the right level for academic and professional success. Developed by Cambridge English Language Assessment - part of the University of Cambridge - it helps you stand out from the crowd as a high achiever. | 60 (Grade C) |
TOEFL paper-based test score : | 580 |
TOEFL iBT® test: | 93 |
China Scholarship Counsil:
The scholarship programme is designed for good quality Chinese students who want to study or do research in the Netherlands for an academic year either during or after their studies in China. The main purpose of the China Programme is the exchange of talented Chinese and Dutch students.
For additional information: Website
Neso Indonesia:
StuNed Scholarships for Master studies, short courses and customized training programmes are available for Indonesian professionals with at least two years work experience in a development-related organization.
For additional information: Website
Fulbright/ NAF:
The Fulbright Center is a bi-national, non-profit organization established by international agreement between the United States of America and the Kingdom of The Netherlands. It promotes educational co-operation and provides information on study, research and internships in the United States.
For additional information: Website
The Ford Foundation International Fellowships Program (Ford-IFP) provides opportunities to exceptional individuals for advanced study. If you are a resident of an eligible IFP country and would like to study in Europe, Nuffic can act as a placement partner for you.
For additional information: Website
European Commission:
The Alban Scholarship programme aims at the reinforcement of the European Union-Latin America cooperation in the area of Higher Education.
* for postgraduate studies.
* for specialization studies at any of the eligible recognised organizations of Higher Training (companies included).
For additional information: Website
For additional information: Website
World Bank:
Successful applicants for the Joint Japan/World Bank Graduate Scholarship Program will be awarded funding covering all tuition and admission fees, as well as housing and subsistence allowance. Travel expenses between the awardees' home countries and Tokyo will also be provided.
For additional information: Website
United Nations:
For additional information: Website
Asian Development Bank:
This scholarship aims to provide an opportunity for well-qualified citizens of ADB's developing member countries to pursue postgraduate studies in economics, management, science & technology, and other development-related fields at participating academic institutions in the Asian and Pacific Region.
For additional information: Website
VU University Amsterdam:
VU University Amsterdam awards its own scholarships to outstanding students joining our international Master's degree programmes. The VU Fellowship is an amount of money between 2.500 and 15.000 Euros to cover a part of the study expenses. The general criteria for selection are excellence, motivatio
For additional information: Website
Accredited by: NVAO in: The Netherlands
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Drs. Feudtner, Lewin, and Cohen discuss the challenges that emerge when the community of providers have different and strong opinions about the benefit of innovative surgical interventions.. Using the example of hypoplastic left heart syndrome, they explore when physicians should discuss options that they personally believe are wrong, but that other doctors think are much better.
OMG, What R They Thinking? The Adolescent Brain, Risk Assessment and Decision-Making
Sconyers/Godfrey Ethics Grand RoundsDouglas Diekema, MD, MPH, University of Washington
Limitations of Resuscitation in Pediatric Patients
Treuman Katz Bioethics Lecture Joan S. Roberts, MD, University of WashingtonJonna Derbenwick Clark, MD, MA, University of Washington
Lessons Learned from Biobanking
Treuman Katz Bioethics LectureEllen Wright Clayton, MD, JD, Vanderbilt University
Ethics of Early-Phase Trials in Children with Cancer
Find out by selecting your child's symptom or health condition in the list below:


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U.S. Edition
CNN's Dr. Sanjay Gupta tells the story of a severely depressed patient, who underwent an experimental surgery in which doctors drilled two holes in her skull to implant a pair of battery-powered electrodes in her brain.
A small electrical charge then stimulates a part of the brain known as ³Area 25,² which is a junction box for the circuits that control our moods. The patients who undergo this procedure have not been helped by anything else. Not psychotherapy; not meds; not even electro-convulsive shock therapy. But about two-thirds of the experimental subjects using Deep Brain Stimulation have improved significantly.
Battery Powered Brain is one of three in-depth stories in one riveting hour hosted by CNN's Randi Kaye and Drew Griffin. CNN Presents premieres an all-new show tonight at 8pm ET, re-airing at 11:00 pm and 2:00 am ET.
He's a former tattoo artist who commands tens of thousands of dollars to speak to schoolchildren worldwide in the name of bullying prevention. While his tattooed face and outrageous tactics may capture the hearts and minds of kids, critics question whether he has a lasting impact.
CNN's Randi Kaye visits two Minnesota schools – one hoping the twenty thousand dollars the community paid Scary will help them solve the bullying problem, the other going a different route after a Scary experience.
The Scary Guy re-airs on CNN Presents this Saturday at 8:00 pm ET, 11:00 pm and 2:00 am ET.
Just how far will a college go to win the NCAA tournament? For a few teams the Secretary of Education calls "bad apples," it may be too far. These schools are not putting true student athletes on the court.
A new study of graduation rates will show almost half of the African American student athletes who will play in the NCAA basketball tournament will not graduate. And at some schools, the graduation rate for basketball players -black and white- is abysmal.
At UConn for instance, over the last four years, an average of only 25% of its men's basketball players graduated and only 14% of its African American players got a degree. Kentucky had a 31% graduation average. At Syracuse it's just about half. CNN's Drew Griffin investigates.
Don't miss 'The Real March Madness' this Sunday during an all new CNN Presents at 8:00 pm ET, re-airing at 11:00 pm and 2:00 am ET.
Law enforcement says it's one of the biggest, most brazen crimes in the U.S. – criminals stealing your tax refund by stealing your identity, going online, and getting the refund money. Police even call it the new "crack cocaine of crime," and in some Florida neighborhoods, it's actually replaced street level drug dealing. Police officials and the Tampa mayor blame the IRS because it allows the refunds to be put on debit cards, and sends out the return before completely checking the information.
For the first time, our investigation shows the fraud as it's happening on the streets of North Miami Beach and Tampa, Florida, we interview two police detectives who are themselves victims, and talk to a police informant who teaches people how to do tax refund fraud. In an exclusive interview, the IRS deputy commissioner says it's a "balancing act" to get the returns out fast to legitimate taxpayers and keep fraudulent ones from going to criminals. The IRS has identified $6.5 billion in ID-related tax refund fraud last year, but does not know how much was going undetected.
"Refund Robbery" is one of four riveting stories you won't want to miss this Sunday on CNN Presents at 8:00 pm ET, replaying at 11:00 pm ET and 2:00 am ET
It's been said that while baseball may be America's favorite past-time, football is its passion. The mentality of the sport is violent by nature, but some players and coaches crossed a fine line that separates fierce competition from thuggery.
The NFL has concluded that the New Orleans Saints have been involved in what's been referred to as "Bounty Hunting," where payoffs were made for inflicting game-ending injuries on other teams' star players.
Just how did the bounty or incentive programs work? And how prevalent are they in the NFL? CNN's Ed Lavandera investigates.
"Bounty Hunters" is one of four riveting stories you won't want to miss this Sunday on CNN Presents at 8:00 pm ET, replaying at 11:00 pm ET and 2:00 am ET.
CNN Presents focuses on fresh in-depth stories and investigative reporting.
CNN Presents airs Sundays at 8:00 pm ET and 11:00 pm ET, and replays Saturday at 8:00 pm ET and 11:00 pm ET.
If you have a tip or story idea, click here.
Click here to access transcripts from recent shows.


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Rush-Copley Medical Group
Home > Find a Job > Physician Opportunities
Rush-Copley has been part of the Fox Valley for over 127 years and has evolved into a busy community hospital with all the technology and interdisciplinary elements found at academic medical centers. Today, our medical staff totals over 500 physicians, with 94.9 percent of physicians being board-certified and representation from over 60 specialties. We are proud to boast physician satisfaction rates at the 97th percentile.**
With more services being offered than ever before, Rush-Copley is continuing our mission of providing advanced medicine with quality outcomes and extraordinary care. The following physician opportunities are currently available. Interested candidates can contact firstname.lastname@example.com for additional information.
Established, 70 plus provider, hospital owned multi-specialty group is adding a BC/BE family medicine physician. Candidate must possess strong clinical skills, as well as excellent interpersonal skills with both patients and fellow physicians. Call is 1:5. This traditional practice opportunity, including both outpatient and inpatient responsibilities, is located in Yorkville, Illinois, at Yorkville Healthcare Center. Rush-Copley Medical Group is a physician network that includes over 60 providers in over 20 specialties. Its close affiliation with Rush-Copley Medical Center provides access to the Fox Valley's best healthcare resource and some of the region's finest specialists. The group boasts overall physician satisfaction at the 99th percentile.*
Offering a competitive guaranteed salary with productivity incentives as well as a comprehensive benefit package including malpractice insurance. Great suburban location with top-notch schools, close to shopping and dining, just 50 miles west of Chicago. Interested candidates can email CVs to firstname.lastname@example.com.
Established, hospital owned cardiology practice is adding a full-time board-certified/board-eligible, non-invasive cardiologist to its physician panel due to growth. Candidate must possess strong clinical skills, as well as excellent interpersonal skills. Cardiac MRI and CTA experience preferred. Call is 1:3. This thriving practice includes seven cardiologists, three nurse practitioners and a seasoned staff with two locations in Aurora, Illinois and one in Yorkville, Illinois. Offering a competitive guaranteed salary with productivity incentives as well as a comprehensive benefit package including malpractice insurance. Great suburban location recognized for its top-notch schools, shopping, dining and overall quality of life just 40 miles west of Chicago. Interested candidates can contact firstname.lastname@example.com for additional information.
Established hospital owned multi-specialty group seeks a full-time certified nurse midwife for a busy, full scope, hospital-based midwifery practice. The position will provide independent management of women's healthcare to a diverse patient population focusing on pregnancy, childbirth, postpartum and primary care with attention to family planning and gynecological needs. We are looking for a dedicated and compassionate CNM committed to providing quality clinical care in a supportive and nurturing environment. Spanish-speaking a plus. Call is 1:2. VBAC and water births offered.
This is an outstanding opportunity to work in a community-based hospital offering a full complement of women's health services with physician collaboration from a five-person ob/gyne group. All deliveries at Rush-Copley, the first hospital in the country to receive the Gold Seal of Approval™ by the Joint Commission for Normal Delivery and Respiratory Distress Syndrome in the Preterm Infant. Rush-Copley also boasts the Fox Valley's only Level III Neonatal Intensive Care Unit.
The practice's location is in Aurora, Illinois, just 40 miles west of Chicago, on Rush-Copley's main campus. We offer a competitive salary and comprehensive benefit package. For more information, contact Mandy Bolander at 630-898-4646 or firstname.lastname@example.com.
Unique family medicine physician opportunity at a hospital-based Express Care setting. Flexible scheduling, competitive compensation and fully paid malpractice insurance. Full-time and part-time positions available now. For more information contact Mary Deans-O'Claire at (847) 697-8868 or by email at email@example.com.
"New Group" offering an outstanding career opportunity, partnership track for a full-time BE/BC Emergency Physician. Offering a professional environment with triple physician coverage and fast track in our award winning department. Current annual volume of 70,000 and growing! Excellent compensation, paid occurrence malpractice insurance and flexible scheduling. For additional information please call Mary Deans-O'Claire, at EMpact, LLC at (847)697-8868 or email your CV to email@example.com.
**2013 Press-Ganey annual physician satisfaction study, 150-299 licensed beds peer group.
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© Copyright 2015 Rush-Copley Medical Center • 2000 Ogden Avenue; Aurora, IL 60504
Main: 630-978-6200 • Physician Referral & Information: 630-978-6700 or 866-4COPLEY (866-426-7539)


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Thursday, August 28 12:19:11
Jameson Irish Whiskey's sales volumes reached 4.7 million cases for Irish Distillers' full year 2013/2014, marking 25 successive years of sales growth for the iconic brand.
Jameson volume growth was 9pc for the year and value growth was an impressive 12pc.
In its biggest market, the USA, Jameson's commanding sales performance continued to grow with 9pc volume sales rise.
The brand also reported growth across its other major markets South Africa (8pc volume) and Russia (4pc volume).
IMPACT Magazine, a key publication for the global spirits industry, ranks Jameson 17th in its top global brands, up a further 2 places since last year, and confirming its strong and consistent progress among the world's elite brands.
At home on the Irish market, there was less to celebrate with the total spirits market down by 11.5pc, according to Nielsen. Irish Distillers said the continued decline in the on-trade (-6pc volume for spirits) and off-trade (-13.9pc volume for spirits) combined with the October 2013 excise increase (15.5pc on spirits) has had a hugely negative impact on the spirits industry in Ireland and the Irish Distillers portfolio of spirits reflected this trend.
Commenting on the performance of Irish Distillers Pernod Ricard for the FY 13/14, Anna Malmhake, Chairman and CEO said: "The sustained progress of Jameson within the Pernod Ricard family of brands has been one of the group's most eminent success stories, growing from 466,000 cases when Irish Distillers joined Pernod Ricard in 1988, to approaching 5 million cases in 2014. Jameson is the No.1 selling Irish whiskey in the world, an Irish export story we should be truly proud of. In addition reaching No.17 in the International Spirits Brands Globally (Impact Ranking – Feb 2014) is a prominent achievement in another successful year for Jameson."
Jameson continues to invest in film as its core sponsorship platform. 2013 saw the launch of the 3rd year of First Shot - Jameson's major co-operation with actor Kevin Spacey and his production company Trigger Street Productions. Designed to discover talented screenwriters and directors from Russia, South Africa and the USA, Jameson First Shot comes with an incredible prize where one winner from each country will have their script made into a short film by Trigger Street Productions, this year starring Academy Award nominated actress Uma Thurman.
For more visit: www.businessworld.ie


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Receipe For 10 wings. Also can be used as a marinade. I usually make 2 bowls of sauce. 1 for marinade and the other for grilling. Marinade over night
servings10 Wings
1 cup water1 (6 ounce) can tomato paste
1/2 cup worcestershire sauce
1/4 cup honey
1/4 cup molasses
1 habanero pepper, minced
1 teaspoon crushed red pepper flakes
1 teaspoon ground black pepper
1/2 teaspoon onion powder
1/2 teaspoon chili powder
1/2 teaspoon dried onion flakes
1/2 teaspoon dried parsley
1/4 teaspoon garlic powder
1/8 teaspoon hickory liquid smoke
1/3 cup white vinegar
Combine all ingredients into pot except the white vinegar and bring to a boil. Next add white vinegar and simmer for one hour. Place wings on grill and baste with saucemy notes
recipe at a glance
type: Quick & Easy
main ingredients: Chicken
cuisine: American
holiday/celebration: Grilling