text:
Send these regional cards in Bengali to your friends and family and send them the choicest blessings of Maa Durga on the magnificient festival of Durga Puja.
Sharodiyar Priti O Shubhechha..
Maa Mangal Moi Aradhonar Ananda Utsab.
Sharodiyar Priti O Shubhechha.
Ashwinner khete kasher uchhas.
Sharodiyar priti...
Send this Maa greetings to everyone on Durga Puja
Matribasir protikar...
Send your good wishes to your near and dear ones.
Happy Durga Puja
A Bengali card to wish happy Durga Puja....
May Maa bless you
Send this classic Durga Puja Bengali card to your near and dear ones.
Moments of togetherness.
Let's cherish the moments of togetherness ..
Ashtami-te tomar anjali..
May the blessings of
Maa Durga fill your
Sharater Shada Megha
Send this Bengali card to wish happy Durga Puja.
Durga Puja Bengali Card
Send your good wishes to your near and dear ones.
Warm wishes on Dugra Puja
Tomar Puja Anande Mukhorito Hoye Uthuk
Tomar Jibon Mongolmoy Hoye Uthuk..
Blessings for you...
Send this beautiful Bengali card to all on Durga Puja.
Good Wishes On Durga Puja
With all the auspicious signs, this card is perfect to send your wishes.
May Maa Durga Bless you
Send this graceful Bengali card to wish a happy Durga Puja.
Happy Durga Puja
Bengali card is apt to wish happy Durga Puja.

subset: commoncrawl


text:
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text:
The recidivism rate in Texas was at one time less than 10%, but then a FEDERAL judge got involved and said,"you can't make them work, in the fields to grow their own food, make their own clothes, etc..." Now they get to sit around all day and watch TV.The recidivism rate for convicted felons is about 50% nation wide. The reason for that can be debated all day long. The USA has the highest encarceration rate of any industrial country in the world. Why, don't ask me.
Before the FEDS got involved in Texas prisons, they produced almost all of their own food, clothing, and even other items that were sold to the cities and counties. The prison system was completly self-supporting. If the inmate wanted to eat, he had to work. There was almost no prison violence or gangs, because when you work 12-16 hours a day, you don't have the energy for much else. The Feds changed that for us.
Was Mr. Horn right? I don't know. But If a criminal gets shot for burgularizing a home, in Texas, that's his problem. Jang's examples of people who turned their lives around, doesn't change my opinion one bit. As I said, yes we put a higher value on property than life. Don't believe me, check out those standard bail amounts I mentioned earlier.


text:
Tea Tree Oil Mouthwash Spearmint 8 oz, Desert Essence
Customer Reviews:
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Shipping Rates
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Order Under $100:$6.99
Order over $100:FREE SHIPPING
Tea Tree Oil Mouthwash
- With Essential Oil of Spearmint & Organic Tea Tree Oil.
- Alcohol Free.
Recommended by many dentists, Desert Essence Tea Tree Oil Mouthwash naturally cleans, reduces plaque buildup and refreshes the mouth and gums. Tea Tree Oil is a completely natural plant extract with inherent antiseptic properties. It is distilled from the leaves of the Australian Melaleuca Alternifolia tree. Desert Essence clear Tea Tree Oil Mouthwash contains no alcohol, artificial colors or sweeteners and is flavored with the natural essential oil of spearmint. Desert Essence Tea Tree Oil Mouthwash, the perfect companion for part of your oral hygiene routine, leaves the breath minty fresh.
Purified water, glycerin, polysorbate 80, organic tea tree oil, aloe vera gel, witch hazel, distillate, ascorbic acid (vitamin C), calcium ascorbate, citric acid, essential oil of spearmint.
No animal ingredients or testing. No alcohol, artificial detergents, color or synthetic perfumes.
Use 1/2 oz of Desert Essence Tea Tree Oil Mouthwash and rinse to leave your mouth minty fresh.
About Time, Chocolate Peanut Butter, 2 lbs, From SDC Nutrition
The products and the claims made about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional.
Products image are NOT always exactly as shown on the photographs. We try to be as accurate as possible with photos. Please check the Title carefully before ordering.
All models are 18 yrs or older.
Copyright © 2002-2014 VitaDigest.com. All Rights Reserved.


text:
Open Water
The popularity of open water swimming has significantly increased so as to move it into a highly competitive part of USA Swimming. Open water swimming events, require thorough planning in order to provide the highest level of safety for athletes, coaches, officials and meet personnel involved in the meet. Georgia Swimming, and all open water swimming events sponsored by Georgia Swimming, Inc., will follow the procedure set forth by USA Swimming for Open Water Swimming. The procedure for establishing and sanctioning an open water swimming meet are outlined in the Georgia Swimming Rules and Regulations Manual (Section 11).
The following are the documents which will need to be completed in order to apply for a sanctioned Open Water Meet.
Open Water Application
Open Water Safety Checklist
Open Water Safety Checklist (Athlete)
If there are any questions regarding the application or sanction process for an Open Water meet, please contact Rob Copeland, Georgia Swimming's Open Water coordinator. firstname.lastname@example.com
Long Course 2014
SwimAtlanta Wins Senior State SwimAtlanta won the Senior State Championships held at UGA this past weekend. Dynamo was second and Stingrays third. Host ABSC won the medium-sized team division while Lanier Aquatics won in the the small team division. Yellow Jackets' Darelle Cowley and ABSC's Yousef Alaskari won the high point awards.
SwimAtlanta Wins Age Group State Champs SwimAtlanta defended its title this weekend at the Georgia Long Course Age Group State Champs at Georgia Tech natatorium. Dynamo Swim Club was second while Chattahoochee Gold finished third. Marietta Marlins won the medium sized team category followed by GCAT and Tidal Wave while Tifton won the small teams followed by AAAA and NGA. Individual High Point winners were: Harleigh Mobley, Nathan Jin, Samantha Mobley, Brendan Hausdorf, Tristen Ulett, Ross Valdez, Emma Alexander, Jack Dolan, Mike Jeschke, Jaclyn Hill, and Alex Ballard.
2014 Boys LC Top Ten 2014 Girls LC Top Ten
Short Course 2013-14
SwimAtlanta Wins AG State Champs SwimAtlanta won the Age Group State Champs held this weekend at Ga Tech. They finished about 1000 points ahead of 2nd place Dynamo, followed by Chattahoochee Gold. Marietta Marlins won the medium team division and Carpet Capital the small teams. Six state records fell. Donna Blaum broke her own 100 fly record and Dynamo (4) and GOLD (1) combined to break all the relay records in the 13-14 girls age group.
Results | Team Scores
Dynamo Wins Senior State Champs Dynamo Swim Club won the Georgia Senior State Champs this weekend at Georgia Tech. They were followed in the large team division by Swim Atlanta and Stingrays. Marietta Marlins won the medium team division while Lanier Aquatics won the small teams.
©2009 Georgia Swimming


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truck is "88" never a problem like this, has fuel, new filter,just cranks an cranks til...
Ford Q&A
Ask Your QuestionAll 1990 Ford F-350 questions
won't start, sat for less than 24 hrs.even a shot of either didn't work,any idea
I actually have a 89 ford f700 with a brake problem
Truck has a gerling brake system,and it has a thumping noise in the brake pedal and the pedal shi...
traveled from ca to az and back
when i came back to calif. i was about 3mi to go then i had engine power loss could not go up the...
a missing in my truck
my truck idles fine but when I go down the road it gets a mis in it I changed the plugs, coil, wi...
No pressure in both radiator hoses coolant smoked an melted resivior
Had just put my plow on went bout 30 miles on highway and smoke started to pour out of coolant ov...
1988 f350 7,3 diesel
If I don't start the truck daily oritsits formore than 10 hrs it won't start. runs smoo...
1989 Ford Econoline Chassis, with Jayco RV. Heater fan stopped.
Fuse was blown, but then, another fuse blew. Where should we have the interior electrical system ...
1987 Ford F350 no headlights or running lights and fuses good
1987 not 1990
why aren't my injectors working?
One day my 460 gas truck just quit running, for no apparent reason. Fuel pump cycles at turn of k...
i have an 88 f350 dually
please tell me why there is not juice to the fuel pum[?
and where is the fuel relay switch?
Not sure on the truck specifics
Who rebuilds water pumps for a Cat 3208 Truck?
ford f350 transmission shifts up and down
hello i have a f350 and when im just cruising throught own at like second gear the transmission w...
1980 ford 350 fuel gauge does not work where to start, tank or gauge?
Problem is fuel gauge has not worked for a long time, has fuel in tank 7 or 8 gals. Where to star...
throuttle body
My gas mileage on my f-350 super0duty is poor. I purchased the truck after it had sat for a year....
How do you take a heater out and replace it with a new one?
This week's top 10
1 pushrod | 6 Hal... |
2 CharlesAutomotive | 7 ziptie12 |
3 globalhelper | 8 autotruckequip |
4 csubak30 | 9 wrayauto |
5 asksteevies | 10 Angel A. |


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Prices of vegetables soared in Karur market as rain impeded free arrival of fresh stocks from various places. Continuous rain over the past week here as well as in their places of origin elsewhere in the state had a telling effect on the prices, traders said. In fact the prices have shot up in particular in the past week due to the slump in arrivals.
While brinjal and onion are being sold for Rs.40 per kg apiece, chillies go for Rs.30 a kg. Carrot too is being sold at Rs.40 for an equal quantity while beans is a bit dearer at Rs.45 a kg.
The same quantity of potato is being sold for Rs.30 and all vegetables are being sold at prices that are 15 to 20 per cent higher than what they were last week.
Even tomato costs Rs.20 a kg while ladies finger costs Rs.22 and radish is being sold at Rs.20 a kg.
The traders fear that if the planned transport strike next week really takes off then the prices might rise again or stabilise there itself without coming down adding to the pressure and burden of the common man. While the series of auspicious dates pushed up prices at the beginning of last month, the torrent allowed the prices to linger there. Now the threat of lorry completes the chaotic scene at the vegetable market.
Keywords: Karur vegetable market, price hike


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The implementation of the tests is on different schedules in the United States and in Europe. In the United States, the tests were originally scheduled to become effective Aug. 1, 2007, but the implementation date has been postponed to May 1, 2009 on the basis of comments received by USP. In Europe, implementation has three different schedules depending upon the situation:
2. Substances not covered by a monograph specification: use either the methods of the European Pharmacopoeia (A) or the harmonised methods (B) until January 2010. From January 2010: use harmonised methods (B).
USP ‹61› "Microbial Enumeration"
The microbial enumeration test is a basic, simple design to count the number of colony-forming units (CFUs) in a nonsterile product or raw material. The preferred method is to put the material into a solution and then plate the aliquots to determine the CFUs/g (or mL) of initial material. If the product cannot be put into a solution, the most probable number (MPN) method has several provisions to use. A full description of the MPN method is outside the scope of this article, but interested readers can refer to the discussion in the US Food and Drug Administration's Bacterial Analytical Manual (8).
The method of plating can be either pour plate, spread plate, or material filtration and then placing the membrane filter on an agar plate surface. The membrane filtration method should only be used when few CFUs are expected to be found in the material to be tested. Though membrane filtration is a good method to test a large volume of liquid, it can only count as many as 100 CFUs/membrane.
The harmonized method provides much more detail than any of the current pharmacopeial methods in terms of demonstrating method suitability (method validation) and media-growth promotion.
Ingredients InsiderCynthia ChallenerFDA Approves Novel Treatments in 2014
EMA Recommends Suspension of 700 Drugs Tested at GVK Site GVK Biosciences argues that EMA's recommended suspension of 700 drugs is disproportional to reported infractions.
Nelson Patterson has been elected to Pharma & Biopharma Outsourcing Association board.
There are significant differences between small molecules and biologics fill/finish capacity.
More Webcasts


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Carrie Underwood – Last Name
by Jermy Leeuwis | genre: Country | posted on March 13, 2008
I am still loving this song hence it deserves a thumbs up! Although its been over three months since it deserved a 'Thumbs Up' here at MusicRemedy. Okay, finally an oldie and classic song. This song will never leave the airwaves so bookmark this single. Never forget..Click on the 'play'-button and enjoy! I give it . |
Listen and/or watch the music video using the RED 'play', 'watch'-button or play/watch-links.
Listen To (short clip)
Listen To | N / A | |
Watch+playlist (should work always) Watch Video
Latest Carrie Underwood News
I never thought that any of this would actually happen to me. These kinds of things only happen to imaginary characters on television or in the movies…not real people. I began my life with the best family in the world already waiting for me. I was the last of three girl(...) Carrie Underwood: Some Hearts


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Serves 2
- 1/2 head romaine
- 1/2 small English cucumber
- 1 small shallot
- 1 small fresh jalapeño chile
- 1 garlic clove
- 2 tablespoons fresh lime juice
- 1 tablespoon soy sauce
- 2 tablespoons vegetable oil
- 2 teaspoons Asian fish sauce
- 1/2 teaspoon sugar
- a 1 1/4-inch-thick rib-eye steak (about 3/4 pound)
- 1/4 cup packed fresh mint leaves
Tear romaine into pieces into a bowl. Halve cucumber lengthwise and seed. Thinly slice cucumber crosswise and add to romaine. Chill romaine mixture, covered. Mince shallot, jalapeño, and garlic (wear rubber gloves when handling jalapeño) and in a large bowl stir together with lime juice, soy sauce, 1 tablespoon oil, fish sauce, and sugar until sugar is dissolved.
Pat steak dry and season with salt. In an 8- to 10-inch heavy skillet heat remaining tablespoon oil over moderately high heat until hot but not smoking and sauté steak 4 minutes on each side for medium-rare. Transfer steak to a cutting board and let stand 5 minutes.
While steak is standing, stack mint leaves and thinly slice. Toss mint with romaine mixture and all but about 2 tablespoons dressing until combined well. Divide salad between 2 plates and slice steak. Toss steak with remaining dressing and arrange on salads.


text:
Want a free ringtone? Audiko.net! It's easy to download a free Kingdom Hearts II ringtones for your iPhone or mobile. Select your favorite segment from your favorite award-winning track - Passion, Sanctuary, Dearly Beloved, or any other track. Then download the prepared Kingdom Hearts II ringtones to your phone, and enjoy Japanese music by Kingdom Hearts II every time your phone rings. If you like Japanese or maybe Soundtracks and Video Game Music music, then you will probably like Yasunori Mitsuda, Hitoshi Sakimoto, or Nobuo Uematsu as well. For all who want a free Kingdom Hearts II ringtone, we also recommend listening to Final Fantasy, and Game Soundtrack. You are welcome to have your tone both in the MP3 and m4a formats, compatible with both mobile phones and iPhones. Just select a track, and choose free Kingdom Hearts II ringtones download option.
Download Kingdom Hearts II Ringtones
Top free ringtones
Name | ||
Dearly Beloved | ||
Sanctuary | ||
Passion | ||
The 13th Struggle | ||
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Tension Rising |
Kingdom Hearts II
Kingdom Hearts II


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Ban Size Zero Models
Following recent revelations of diet-based deaths in size zero models and the commendable actions taken by Milan and Madrid Fashion shows to clamp down on size zero and unhealthy models. The London Fashion Show has decided not to follow suit. I hereby add my name to this petition and declare that the designers, organisers, and funding organisations of the London Fashion Show should ban size zero and unhealthy models (those with a BMI under 18). I believe that they have a moral responsibility, to not only protect vulnerable young girls and women from aspiring to unhealthy lifestyles and body ideals, but also to the oppressed models who struggle to unhealthily achieve the size zero image.
Recent signatures
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3 years ago Comments: nZ1wp2 jpfmjomixgfi, wjqusstpyxej, mlhbbsdyeozn, http://fkyrcwtsjmes.com/
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1983 Audi Ur quattro Coupe finished in Mars Red with Dark Brown full leather. The Audi Ur quattro (Ur, German for original or first of... More
PES G4 supercharged 2007 Audi RS4. Full PES G4 supercharger system, full Milltek performance exhaust, factory-optional Premium Package & rear side impact airbags. PES... More
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2007 Audi RS4 Quattro Sedan 4D Titanium Package, AFTER MARKET FEATURES -- Ohlins Stasis coilover suspension - with oil reservoirs; Giovanna 20" wheels; Brembo Gran... More
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Published on Nov 20, 2012 7:12 PM
AT 14 years of age, she started prostituting herself for amounts ranging from $10 to $100. Her clients were Bangladeshi cleaners and they would have sex at staircase landings in Hougang. The girl, now 15, is now being cared for at the Pertapis Centre For Women and Girls.
Five of her clients were jailed for between 10 and 17 months today by a district court. The men, aged between 23 and 31, had pleaded guilty earlier.
Then, the court heard that the girl's parents were also cleaners and she got to know some of the Bangladeshi workers.
Jojnal Jilhaque Khalifa, 31, a foreman of a cleaning crew, paid her $12 to have sex late last year. In July this year, he had sex with the girl's 14-year-old friend for $40.
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Cala Mesquida, Mallorca
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Traffic Control: BDNF Boosts SORLA, Reroutes APP
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The sortilin-related receptor protein SORLA (aka SORL1) controls the trafficking and processing of the amyloid precursor protein (APP), and thus serves as a key regulator of amyloid-β (Aβ) production in the brain. But what regulates SORLA? A new report from Thomas Willnow of the Max Delbruck Center for Molecular Medicine, Berlin, Germany, and Anders Nykjaer, Aarhus University, Denmark, provides an intriguing answer to this question. In work published in the December 9 Journal of Neuroscience, Willnow, Nykjaer and colleagues show that brain-derived neurotrophic factor (BDNF) induces SORLA expression in mouse neurons in vitro and in vivo, which leads to a reduction in APP processing to Aβ. Both BDNF and SORLA are lacking in the brain in Alzheimer disease, and the study links the two, raising the possibility that some of the protective effects reported for BDNF in AD might stem from diminished Aβ production.
Willnow and Nykjaer had previously discovered that SORLA regulates the travels and processing of the amyloid precursor protein (APP), steering it away from cell compartments that favor amyloidogenic processing and thus reducing Aβ production (Andersen et al., 2005). Consistent with this role, knocking out SORLA worsens pathology in an AD mouse model (see ARF related news story on Dodson et al., 2008). Human studies implicated SORLA in AD. Expression of the receptor is reduced in brain tissue from AD patients (Scherzer et al., 2004; Dodson et al., 2006), and SORLA gene variants are associated with the risk of late-onset AD (see AlzGene entry for SORL1).
To explore possible regulators of SORLA, first author Michael Rohe took a screening approach, testing nine different trophic factors for their ability to elevate SORLA mRNA in newborn mouse primary cortical neurons in culture. The best inducer by far was BDNF, which caused a seven- to 10-fold elevation of SORLA mRNA and a 60 percent increase in protein levels within 48 hours of treatment. In vivo, too, BDNF appeared to be a major regulator of SORLA levels. Brain extracts from newborn BDNF knockout mice contained 40 percent less SORLA protein than did their normal littermates. Also, SORLA levels were down in a mouse model of Huntington disease, where loss of BDNF is part of the phenotype.
Given that SORLA restrains the amyloidogenic processing of APP, the researchers asked whether BDNF had any effect on Aβ production. They found that adding the growth factor to primary neurons slashed Aβ40 production by 40 percent. This depended on SORLA induction, as BDNF had no impact on neurons from SORLA knockout mice, despite the normal activation of the BDNF receptor and downstream signaling pathways. BDNF increased SORLA expression and reduced Aβ40 and 42 production in neurons from PDAPP mice, an AD model that overexpresses a mutant human APP gene. In vivo, intracranial injection of the factor into the hippocampi of mice caused a 40 percent drop in Aβ40 levels. Consistent with the in vitro work, no change in Aβ production was seen under the same treatment regimen in SORLA-deficient mice.
Finally, Willnow and colleagues looked at the signaling pathways involved in SORLA induction by BDNF. Processing of SORLA by γ-secretase has been shown to downregulate SORLA expression, but the German scientists found that treating cells with γ-secretase inhibitors did not interfere with the effects of BDNF. On the other hand, inhibiting the MEK/ERK pathway could prevent SORLA induction.
BDNF replacement has been proposed as a potential treatment for AD, based on its downregulation in AD brain and recent studies showing that chronic delivery of the factor either by lentiviral expression (see ARF related news story on Nagahara et al., 2009) or via stem cells (see ARF related news story on Blurton-Jones et al., 2009) improves synaptic density and cognition in two mouse models of AD. However, in neither study was there any reduction of plaque load in response to treatment, and the authors attribute the effects of BDNF to its better-known trophic actions.
How to reconcile the disparate results? The studies are difficult to compare with the new study, Willnow wrote in an e-mail to ARF, because models, treatment regimens, and endpoints measured were quite different. "In our work, we aimed at testing the acute effects of high doses of BDNF application in the hippocampus and in primary neurons on upregulation of SORLA gene expression and local Aβ formation. Therefore, we determined the amount of soluble Aβ formed acutely during seven days of BDNF infusion into the hippocampus. This experimental condition will not clarify whether chronic application of BDNF will also induce SORLA gene expression and reduce long-term Aβ formation and senile plaque deposition," he noted.
"There is no doubt that BDNF has many pleiotropic effects on neuronal function and cognitive performance, some likely dependent, others independent of APP metabolism," Willnow concluded. For SORLA aficionados, the work opens up a new set of interesting questions about whether and in what way their favorite protein may support the trophic actions of BDNF in neurons.—Pat McCaffrey
Comments on News and Primary Papers
This paper provides solid support for the idea that BDNF can regulate SORLA expression via ERK activation. It presents interesting findings showing that BDNF, acting via SORLA, can decrease Aβ generation in wild-type mice and primary neurons.
This is a tantalizing finding, as previous studies, including our own, did not see altered Aβ in aged 3xTg-AD mice following neural stem cell treatment, despite the fact that the NSCs produce and elevate levels of BDNF (Blurton-Jones et al., 2009). Another group led by Dr. Mark Tuszynski also did not observe any changes in Aβ in the J20 mouse model following viral BDNF delivery.
There are a couple of likely explanations for the differences between the effects of BDNF on Aβ generation in the study by Rohe et. al. and our own data:
Firstly, the concentration of BDNF used by Rohe et al. in vivo (40 ug/hippocampus) is substantially higher than the elevation of BDNF we see in the brain following NSC delivery. We find by ELISA that brain levels of BDNF increase from about 10.5 pg/mg of tissue to 15 pg/mg. That translates to an increase in total brain BDNF from 4.2 ng up to about 6 ng. Thus, the supraphysiological levels of BDNF used in vivo by Rohe et al. may complicate the interpretation of these results. It would be very interesting to know if the converse is true; that is, do mouse Aβ levels decrease in the Huntington model or BDNF knockout mice that they utilized? We think this would more clearly address the physiological effects of BDNF on APP metabolism.
Another important difference between our findings and the current study is that Rohe et. al. examined the effects of BDNF in wild-type mice. Our study utilized the 3xTg-AD mice, and Dr. Tuszynski's study utilized the J20 line. Both of these transgenic models harbor the Swedish mutation that enhances β-secretase cleavage of APP. Thus, the effects of the Swedish mutation on APP processing might override any influence of BDNF and SORLA that might have driven non-amyloidogenic processing of APP in our study. This suggests that it may be very interesting and important to perform these kinds of experiments in mice that express wild-type human APP.
Overall, this study adds intriguing information about the possible connections among BDNF, SORLA, and AD. Although we would respectfully argue that studies that examine the effects of more physiologic reduction or elevation of BDNF would help to more precisely define the relationship between BDNF and APP processing in vivo.
Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, Laferla FM. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13594-9. PubMed.
The article by Rohe and colleagues presents data derived from in vivo and in vitro studies demonstrating a novel role for brain-derived neurotrophic factor (BDNF) in the induction of SORLA, which regulates intracellular trafficking and processing of APP into Aβ, via the ERK pathway. Despite the caveat that several of the findings presented to support this concept were derived from cultured primary cortical neurons from newborn mice—which are more indicative of developmental processes—evidence is also presented showing that BDNF acts as a physiological inducer of SORLA in a transgenic AD model of amyloidosis. Taken together, these findings lend support for the translation of their data to the actual disease state.
According to the findings of the Wilnow group, the induction of SORLA gene transcription may be part of the normal actions of BDNF in the brain. How are these proteins affected in AD? Cortical SORLA levels are reduced to a greater extent in those people with MCI who display a more pronounced cognitive impairment (Sager et al., 2007). Both BDNF protein and mRNA are decreased in the cortex and hippocampus beginning at the prodromal stages of AD (Peng et al., 2005). What would be the consequences of the concurrent down regulation of these proteins early in the onset of AD? One possible outcome may be the loss of the inhibitory role of BDNF on APP processing to Aβ, culminating in increased plaque formation in the brain during the development of AD. Hence, elucidating the mechanisms underlying BDNF reductions in the cortex and hippocampus may uncover a pathogenic pathway causing a double-hit in incipient AD: the loss of survival signaling via reduced neurotrophin receptor stimulation and the gain of toxic amyloid accumulation via SORLA downregulation.
Sager KL, Wuu J, Leurgans SE, Rees HD, Gearing M, Mufson EJ, Levey AI, Lah JJ. Neuronal LR11/sorLA expression is reduced in mild cognitive impairment. Ann Neurol. 2007 Dec;62(6):640-7. PubMed.
Peng S, Wuu J, Mufson EJ, Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem. 2005 Jun;93(6):1412-21. PubMed.
View all comments by Scott Counts -
The finding that BDNF reduces Aβ production by regulating the expression of SORLA is a potential link between degeneration of the locus coeruleus (LC), the main source of the neurotransmitter norepinephrine in the limbic system and forebrain, and the development of AD neuropathology. Although it is well established that LC neurons degenerate early in AD, the functional consequences are not well understood. In general, the LC appears to protect against Aβ neuropathology. For example, lesions of the LC enhance Aβ plaque formation in transgenic mice that overexpress mutant APP, a commonly used animal model of AD (Heneka et al., 2006).
Intriguingly, LC neurons express and release BDNF, and NE itself can promote BDNF expression in target neurons; thus, when LC neurons degenerate early during the early stages of AD, this source of BDNF is lost or greatly reduced. The newly described ability of BDNF to increase SORLA suggests that one consequence of LC degeneration could be a decrease in SORLA expression, leading to dysregulated sorting of Aβ and again resulting in greater amyloid plaque deposition in the LC denervated cortical and hippocampal target sites.
Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M. Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci. 2006 Feb 1;26(5):1343-54. PubMed.
We would like to comment on two aspects raised by the interesting paper by Rohe et al. (1), which elegantly shows that BDNF can control the amyloidogenic processing of APP by regulating the expression of SORLA. This pathway of regulation suggests that the expression of SORLA, a protein that controls a trafficking event—that of APP—could be itself controlled by another trafficking event, i.e., the axonal transport of BDNF.
This brings us to the hotly debated question of whether abnormal axonal transport is a cause, a contributing factor, or a consequence of the pathology in Alzheimer disease (2). The study by Rohe et al. (1) certainly points to the possibility that an impeded axonal transport of BDNF—described as a possible pathogenic factor in several neurodegenerative diseases—could lead to increased amyloidogenic processing of APP, through the downregulation of SORLA. Deficient transport of BDNF has in fact been proposed to occur in Huntington disease (3,4).
In AD, BDNF levels are reduced (5-7), and it is possible that this is also a result of reduced transport of BDNF.
In view of the present study, in all neurological disorders where BDNF trafficking is impeded, APP metabolism could—in principle—also be altered. If Rohe et al. (1) are correct, one could expect that APP is abnormally processed, in relevant brain regions, in all neurodegenerative disorders where the levels of BDNF are reduced.
We would also like to draw attention to the equally interesting comment by David Weinshenker, which points to the possibility that a deficient release of BDNF from locus ceruleus (LC) neurons could lead to increased production of Aβ in remote brain regions (e.g., hippocampus, cortex), where the LC neurons project. We have recently proposed that LC neurons could also provide the seed of aggregated Aβ that may nucleate the formation of the neuritic plaques in lesion-prone regions (8,9).
Interesting, in this way, the LC neurons could not only provide the seeds, but also trigger the generation of the soluble Aβ that aggregates into plaques. Thus, the AD pathology in the LC may not be a secondary event caused by Aβ poisoning of the projections of LC neurons. The deficiency of LC neurons, which—as pointed out by David Weinshenker—occurs early in AD (see also [10]), could be a cause and a facilitating factor rather than a consequence of the pathology in the lesion-prone brain regions.
See also:Muresan, Z. and V. Muresan, Brainstem Neurons Are Initiators of Neuritic Plaques. SWAN Alzheimer Knowledge Base. Alzheimer Research Forum
Rohe M, Synowitz M, Glass R, Paul SM, Nykjaer A, Willnow TE. Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci. 2009 Dec 9;29(49):15472-8. PubMed.
Muresan V, Muresan Z. Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?. Future Neurol. 2009 Nov 1;4(6):761-773. PubMed.
Dompierre JP, Godin JD, Charrin BC, Cordelières FP, King SJ, Humbert S, Saudou F. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci. 2007 Mar 28;27(13):3571-83. PubMed.
Gauthier LR, Charrin BC, Borrell-Pagès M, Dompierre JP, Rangone H, Cordelières FP, De Mey J, MacDonald ME, Lessmann V, Humbert S, Saudou F. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell. 2004 Jul 9;118(1):127-38. PubMed.
Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, Laferla FM. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13594-9. PubMed.
Laske C, Stransky E, Leyhe T, Eschweiler GW, Wittorf A, Richartz E, Bartels M, Buchkremer G, Schott K. Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm. 2006 Sep;113(9):1217-24. PubMed.
Peng S, Wuu J, Mufson EJ, Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem. 2005 Jun;93(6):1412-21. PubMed.
Muresan Z, Muresan V. Seeding neuritic plaques from the distance: a possible role for brainstem neurons in the development of Alzheimer's disease pathology. Neurodegener Dis. 2008;5(3-4):250-3. PubMed.
Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M. Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci. 2006 Feb 1;26(5):1343-54. PubMed.
View all comments by Virgil Muresan


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Douglas W. Kmiec: Democrats Steps Toward Honoring Life in Their Party Platform Comments
"Having drafted their platform, the Democrats should reopen doors that never should have been shut toward pro-life Democrats." says Doug Kmiec. Continue Reading
41 - 48 of 48 Comments
6 years ago
The Democratic Party and Senator Obama embrace abortion because to oppose it costs them votes. Bill Clinton tapped danced around the issue when his wife was running saying that very thing. They are the party of true cynics. To know that you are risking thousands of lives to gain votes. There is nothing idealistic in the support of abortion. The new Democratic Party has left me behind. I can no longer believe in or support the hypocracy that comes with supporting abortion. Attempts to make it acceptable or explain it away won't work. To do so aids the continuation of the threat to life. Senator Obama may have great "vision" but the devil is truly in the details here.
6 years ago
The Democrats will never oppose abortion any more than they will same sex marriage. A few years ago Howard Dean made the claim that the Democrat party does not and never has support abortions or same sex marriage. This, of course is a lie and, in my opinion, just about everything they say is a lie. They know that both abortion and same sex marriage are wrong but continue to support them and pretend they don't and believe that we are too stupid to know the difference. As long as the Democrats support both they will never get my vote.
6 years ago
This article is unreal. You are trying to tell me that the man who has gone out of his way to remind us that he has a 100% rating from planned parenthood is somehow pro-life? Explain to me how endorsing the freedom of choice act, which requires that the states provide on demand abortion, is anything less than endorsing whole sale slaughter of the most innocent of victims. A vote for Obama is a vote for an increase in abortions.
Even Hilary Clinton would be a better choice for a pro-life person and that is saying a lot.
The author needs to seriously reexamine his faith if he thinks that Barak Obama is an acceptable person to vote for. Abortion is not an issue of relativism, either you support the premeditated murder of the unborn or you don't. There is never a case where it is somehow acceptable. In a world of grays this issue is 100% black and white.
6 years ago
Is Obama's charm so overwhelming it can mesmerize Mr. Kmiec to the extent that he would urge us to abandon the effort to overturn Roe? It must. Otherwise there is no explanation for the muddle-headed hocus pocus emanating from Mr. Kmiec's brain.
"Barak Obama is a different type of candidate". He's not! He tried to pretend he is different and new and messiah-like. He fooled many for a while, but we've all seen through him by now. Why hasn't Mr. Kmiec? Obama tries to make the old Democratic ploys look new ("safe, legal and rare", prenatal help, and, of course, the "prevention first" hoax), and Mr. Kmiec buys it, as if he hadn't been hearing those ploys for years now, and as if Obama had not already proven to be the most pro abortion cndidate ever. Kmiec says Obama is new and different in that he regards abortion as a moral question which only the woman can decide. That is NOT new or different. I've heard Hillary, Al Gore and other prominent committed pro aborts mouth that shiboleth ten years ago to soften the hard edge of the pro abortion image. The greatest soft sell that the Democrats are trying right now is to persuade pro lifers to abandon the effort to reverse Roe in return for vague, fuzzy promises to support adoption or provide more contraceptives to reduce the number of abortions - which we know is fallacious. What a coup they would score if they could swing that. Mr. Kmiec, arise from your Obama-induced hypnosis and recover the objectivity you once seemed to have. Until you do, may I suggest you are not in a position to represent pro life. -
6 years ago
The Christian Defense Coalition uncovers that at a July 17, 2007 Planned Parenthood Action Fund event, Senator Obama said, "Well, the first thing I'd do as president is, is sign the Freedom of Choice Act."
I like you Doug Kmiec, but you are grasping at straws. PLEASE see the light. Obama is a baby killer, PERIOD.
6 years ago
Doug...all the Dems have done is suggest sex education augment their abortion-on-demand plan. We all know that sex education, particularly the liberal kind, does nothing to praise virtue and everything to tear down social and religious barriers to promiscuity.
Making the "safe, legal, and rare" argument is exactly the same as drawing a line between slave states and free states. Either the embryo/fetus/baby is a human being and Constitutionally protected, or they are not...and the Church says they are.
The Dems say the child is no different than an appendix that can be removed at will. Hogwash.
Professor...in the military vernacular, "you're pissing up a rope" on this one. -
6 years ago
Doug, there is a lot of good sense in this article, but two points you made really need to be challenged:
(1) You stated that Obama's theory of government "puts the person at the center--not to have the government impose from top-down": I think one could fairly argue that given his opposition to parental choice in schooling, and the huge new regulatory bureaucracy he is proposing as part of his Health Care plan, his theory of government is to put the GOVERNMENT at the center, as the universal nanny to look after the good of the human person. He does not seem to have much place in his theory for the Catholic principle of "subsidiarity." Remember also that Obama supports federal Freedom of Choice act, a top-down attempt to impose abortion on demand on all the states.
2. You wrote: "The Republicans are dug in on seeking the elusive 5th vote to overturn Roe....overturning Roe does nothing directly to save a life; it merely tosses the issue back to the states." C'mon, Doug: you know and I know that as soon as Roe is repealed, dozens of states will pass laws similar to South Dakota's anti-abortion law, and many lives of unborn children will thereby be saved.
Again, you are certainly right to argue that being pro-life means more than just supporting anti-abortion laws: it means creating a condition of welcome for every new life conceived, including adequate adoption-option support, maternity leave provisions, etc. But are the Republicans leaving such things out of their platform? Let's wait and see.
6 years ago
Some please challenge this fraud. Honestly, how does he even show his face at Mass? Nothing he has mentioned here is a change at all from any pro-death Democratic position. No wonder he doesn't even try to debate, but submits his articles hoping nobody will notice.
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Awful, just Awful
By Gary
from Pa
Comments about HFT 6 Pack 60 Yd. x 1 In. Blue Painter's Tape:
Worst tape I ever used. Can't peel more than 4-5 inches without it tearing. Contacted HF 2 weeks ago, still no response.
Comment on this review
(1 of 1 customers found this review helpful)
Bad Product
By HFT Customer
from Sacramento, CA
I've had nothing but problems with this tape. After applying it around windows and doors, the tape peeled up in a matter of minutes. "Low tack" is one thing but this is ridiculous. Very disappointed with the product.
(5 of 5 customers found this review helpful)
Absoute Garbage
By Car Nut
from Fallbrook, CA
This tape is absolute garbage. It's not possible to tear off more than a few inches without the tape tearing on its own. Also, if left on a project for more that a day, it leaves a residue and is hard to get off. This is in no way comparable to the "good" blue painter's tape. Do not buy this inferior product.
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Pilgrim at Tinker Creek is the story of a dramatic year in Virginia's Blue Ridge valley. Annie Dillard sets out to see what she can see. What she sees are astonishing incidents of "mystery, death, beauty, violence."
Publisher: HarperCollins e-books (October 13, 2009)
Collection: HarperCollins e-books
Format: EPUB
File size: 457 KB
Protection: DRM
Language: English
Awards: Pulitzer Prize for General Non-Fiction 1975 winner


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Describe the Ugliest Scrubs You Have Seen! - page 8
Geez, I volunteer @ a hospital where I have seem more than my share of ugly scrubs! Interested to know what's the ugliest you have seen out there. I have 2 that come to mind: (1) NASCAR race cars... Read More
1Nov 11, '10 by PacoUSA, BSN, RNHopefully some people will learn!
The top 5 scrubs fashion blunders:
6 dos & don'ts for putting together great scrubs outfits:
http://scrubsmag.com/6-color-tips-when-picking-scrubs/JacobK likes this. -
3Dec 27, '10 by GitanoRN GuideI can't stand the huge Flower prints or the 3 million animal Zoo print, even if you work in Peds. The huge Flower print looks like Laura Ashley threw-up all over the place, and the Zoo print looks like they about to attack you that's what one 5yr. old told his mother on my facility. Try to tone down the prints especially if you're over weight.
5Dec 28, '10 by mushrooms4I worked with an old "hippy" kind of nurse, who didn't wear underpants under his scrubs, I found this out when he was performing CPR and his scrubs came untied (string caught on the bedrail) and down they came! (Roomful of people all saw more than they bargained for)
3Jan 6, '11 by fuzzywuzzyI hate the demin-look scrubs... do you wear denim head to toe outside of work? Ugghh.
0Jan 7, '11 by turnforthenurseRNThe scrubs themselves were cute, but not on this nurse! This nurse is really overweight and her scrub top was just a little too short...needless to say, you could totally see her foopah sticking out at the bottom!!
0Jan 7, '11 by ky_grl82Quote from Paco69Perfect example of what I am talking about, non-peds ... I call this a scrubs FAIL. Sorry for the blurry image, it's zoomed in and lost a lot of resolution but you get the idea of what the design is. The background color is poop brown (not the "nice" brown someone described previously), and bottoms are black!
wow, that scrub top looked like something from a bad acid trip.... or Fantasia! lol -
1Feb 1, '11 by DarkfieldA distribution person who wears a scrub top with high rise elastic waisted jeans.sevensonnets likes this.


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Myanmar democracy veteran Win Tin dies at 85
Win Tin, a veteran of Myanmar's pro-democracy movement, has died at the age of 85.
A founder of the Aung San Suu Kyi-led National League for Democracy, Win Tin was seen as highly influential in the push for reform in the South East Asian nation, formerly called Burma.
He served 19 years in prison under Myanmar's military rulers for his activism, but was released in 2008.
An NLD spokesman described him as a "great pillar of strength".
"His demise at this important political juncture of transition is a great loss not only to the NLD but also to the country. We are deeply saddened," said Nyan Win.
Win Tin was greatly admired by pro-democracy supporters - he had the guts to stand up to the military regime and also, when he felt it necessary, to opposition leader Aung Sang Suu Kyi. When he disagreed with her he would tell her straight, the only person in the National League for Democracy with the stature to do so.
For example, he publicly opposed her decision to contest by-elections in 2012 as part of a reform process. Win Tin argued that running for parliament was tantamount to endorsing a constitution that needed to be changed first. But he was loyal and believed in a united opposition - once Ms Suu Kyi made the decision, he stood by it.
People looked up to Win Tin as someone who held to his convictions right to his death.
There was no one else like him, and now he is gone it is not clear who, if anyone, might take on his counterbalancing role in the party.
Win Tin had been in hospital with respiratory problems since 12 March, the Associated Press news agency reported.
Blue shirt messageWin Tin was a newspaper editor before his political activism led to his arrest in 1989 and subsequent incarceration in Yangon's Insein prison.
Much of his time in prison was spent in solitary confinement and his sentence was twice extended.
Freed in 2008, he continued to wear his blue prison shirt as a protest because others were still being held.
"When I was released, there are about 500 or so political prisoners... behind the bars," he told the BBC in April 2013.
"I said that I am going to wear it in the future. So long as these political prisoners are behind bars, I must wear this shirt and this uniform, the colour of the prison, you see, blue colour. I want to show my solidarity with them."
Two years after Win Tin's release, Myanmar held its first elections in 20 years. The polls, nominally, aimed to replace military dictatorship with civilian rule, subsequently installing a military-backed civilian government led by former military officials.
The NLD boycotted the polls, but then re-entered the political fold as the government embarked on a process of reform that saw some political prisoners freed and media censorship relaxed.
The NLD now has a small presence in parliament and its key focus is the general election due in 2015.
After his release, Win Tin continued to work with the NLD despite recurrent health problems.
He was not afraid to criticise members of his own party, in particular those he saw as being too reverential towards Aung San Suu Kyi, reports the BBC's Jonah Fisher from Yangon, formerly known as Rangoon.
And while he welcomed the reform process - telling the BBC in March 2012 that he could see "light at the end of the tunnel" - he spoke out against what he saw as too conciliatory a stance towards the military, for whom 25% of the seats in parliament are reserved.
"We have to co-operate to some extent but we cannot compromise all the time," he told Reuters in April 2013.
"So, I might be a very lonesome voice, not a loud voice, but I must say so all the time."


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Read what other Viator.com travelers think about the Island Snorkel Cruise from Freeport with Lunch. What they loved, what they liked and what they think could be improved, it's all here to help you make the most of your next trip.
Click here for tour details, schedule and pricing
This tour was the highlight of my family's trip. It was such a nice day and everything went so smoothly! All of the tour guides were so nice and accommodating to everyone. The snorkeling was amazing and so was the private beach with lunch!! I would highly recommend this tour to anyone visiting Freeport.
Fantastic! One of the highlights of our trip. Snorkeling was great the deserted beach was even better with a good lunch and drinks. Bring extra cash for beer or soda. Def take this trip!
Wexcellent Tour, The Coral Was Nice, They Sold Dog Food which Is A Must Have If You Wanna See Fish. Lunch Was Great, But They Ran out Of Food After Everyone Had There First PlaTe, But It Was excellent Tasting. Over All Excellent Tour
The guides were incredibly helpful--the boat captain, the German fellow, and the young lady who stayed in the water with my wife when she was initially a bit worried about snorkeling. Peterson Cay was fabulous. The water was a bit choppy but it appeared to bring out more fish.


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Resources Home CSS3 and HTML5 Articles
User rating:
CSS Only Lightbox Viewer Using CSS3 Transitions
A case of CSS replacing JavaScript completely to create a intricate lightbox.
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CSS Circle Menu
This CSS example uses CSS3's border-radius property that's set to a very large value to create circle menu links.
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Pure CSS3 Post Tags
This article illustrates the use of two CSS techniques, CSS triangles and CSS circles, to create cool looking "tags".
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Newest Design Trends with Popular CSS3 Techniques
A look at some emerging trends based on popular CSS3 techniques on the web.
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Create Spinning Rays with CSS3 Animations & JavaScript
This article shows how to use CSS3's transform property plus a little JavaScript to rotate a background image periodically and create spinning rays!
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20 Excellent HTML5 Video Players
This post showcases a list of great HTML5 media players that you can use today.
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Designing Search Boxes with HTML5 and CSS3
Three simple demonstrations of using CSS3 and HTML5 to beautify a search form.
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Text-overflow CSS3 property explained
Using CSS3's text-overflow property, one can easily add an ellipsis to truncated text to indicate there is more text to follow.
User rating:
Creating a Speech Bubble With CSS3
Using the CSS3 pseudo-element :after plus the fact that borders in CSS are met at an angle, this article shows you how to create pure HTML speech bubbles.


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Welcome to Litin Eco
"Litin Eco. We make it easy to be green."
Learn more about World Centric Compostable Products.
Take a moment to shop World Centric, Earth Friendly, and other eco-friendly products on our Vendor Pages or click on the product icons that interest you. Call us for any questions and to place your order. We look forward to helping you, because at LitinEco...
We Think The Color Green Looks Good on Everybody.
Click the decal to learn how your business
can join Minnesota Waste Wise.


text:
CPSC Announces Recall
Posted: 04/10/2008 - FUNTASTIC recalls fake teeth due to violation of lead paint standard and Michaels stores recall seasonal writing pens due to violation of lead paint standard.
Posted: 04/10/2008 - FUNTASTIC recalls fake teeth due to violation of lead paint standard and Michaels stores recall seasonal writing pens due to violation of lead paint standard.
Posted: 04/10/2008 - Kentucky Education Commissioner Jon Draud says the state budget passed by lawmakers last week doesn't provide school districts with the resources they need.
Updated: 04/10/2008 - Kentucky's execution protocol is now public after the U.S. Supreme Court ordered its release as part of a case challenging lethal injection.
Posted: 04/10/2008 - The co-pilot and lone survivor of a deadly plane crash that killed 49 people will be interviewed later this month by attorneys for families suing Comair.
Posted: 04/10/2008 - One of the first responders to the crash of Flight 5191 is now being honored with a "Carnegie Hero" medal for his efforts.
Posted: 04/10/2008 - A federal judge has signed off on a settlement requiring Massey Energy Co. to pay a record $20 million fine for alleged pollution violations.
Updated: 04/10/2008 - A judge has denied Comair's request to have its case against the Federal Aviation Administration considered before a trial over the 2006 plane crash that killed 49 people.
Updated: 04/10/2008 - An investigation is now underway into what caused a deadly overnight crash in Laurel County.
Posted: 04/10/2008 - A worker at a southern West Virginia newspaper is accused of stealing a copper part worth hundreds of dollars and selling it for 34 dollars.
Posted: 04/09/2008 - Emergency management workers say it appears someone stole a gas pump from the Joshua Enterprise Coal Mine, causing some fuel to leak into nearby Feds Creek.
Posted: 04/09/2008 - A worker at a southern West Virginia newspaper is being accused of stealing a copper part worth hundreds and selling it for $34.
Posted: 04/09/2008 - Testimony continues in the federal trial of a Knott County secretary and her father charged with perjury.
Updated: 04/10/2008 - Some may find the video disturbing. Workers at a Southern Kentucky animal shelter are caring for a Great Dane they say is one of the worse cases of neglect they've ever seen.
Posted: 04/09/2008 - Some local attorneys who represent people who don't have the money to hire their own lawyer could lose their jobs.
Updated: 04/09/2008 - Road crews closed Highway 321 in Floyd County Tuesday and the road remains closed to everyone, including emergency vehicles.
Posted: 04/09/2008 - A former state representative that resigned just weeks before the 2008 General Assembly session now has a new job.
Posted: 04/09/2008 - Kentucky's primary is still more than a month away but county clerks say if you are planning to vote absentee, there are a few steps you have to take first.
Posted: 04/09/2008 - Police arrest a teenager in Southern Kentucky for allegedly making a bomb threat and you may not believe how police were tipped off.
Posted: 04/09/2008 - More than a dozen items taken from the Bobby Davis Museum in Hazard are recovered.
Updated: 04/09/2008 - The state has now filed charges against the owner of a Rowan County farm where dozens of dead horses were found.
Posted: 04/09/2008 - It happened on Highway 1247 near Science Hill.
Posted: 04/09/2008 - Preliminary statistics* indicate that eleven people died in eleven separate crashes on Kentucky's roadways from Monday, March 31 through Sunday, April 6, 2008.
Posted: 04/09/2008 - A Kentucky student won't be allowed to proceed with a lawsuit against his school district for instituting a policy that barred him from expressing his opposition to homosexuality, a federal appeals court ruled Wednesday.
Updated: 04/09/2008 - The audit shows more than one million dollars in FEMA grants unaccounted for and questions financial management under Former Leslie County Judge Executive Kenneth Witt.
Posted: 04/09/2008 - Gov. Steve Beshear today signed into law four bills passed by the current session of the Kentucky General Assembly.


text:
Special dividend -- On September 30, the Company paid a special dividend of $0.18 per ADS to shareholders of record at the close of business on August 31, 2011.
Share repurchase program -- On September 30, the Board approved a share repurchase program of up to $20 million of the Company's outstanding ADSs. Through November 11, 2011, Concord Medical has repurchased 140,623 ADSs, representing 421,869 ordinary shares, in the open market.
Pending acquisition -- The acquisition of the Chang'an Hospital is still pending the conclusion of the due diligence and the required government approval. Concord Medical will endeavor to complete the acquisition by the end of 2011.
Third Quarter 2011 ResultsNet revenues were RMB124.7 million ($19.6 million)(A) in the third quarter 2011, up 23.4% from the third quarter 2010, primarily due to an increase in patient cases at existing centers and centers we have added since September 30, 2010.
Cost of revenues was RMB41.8 million ($6.6 million) in the third quarter 2011, up 22.4% from the third quarter 2010, primarily due to higher consumables and equipment maintenance charges in support of higher revenues.
Gross profit margin was 66.5% in the third quarter of 2011 compared with 66.2% in the third quarter 2010. The higher gross profit margin was primarily due to higher net revenues, which more than offset the increase in consumables and equipment maintenance charges as a result of effective cost control.
Operating expenses, consisting of general and administrative expenses and selling expenses, were RMB25.0 million ($3.9 million) in the third quarter 2011, up 44.8% from RMB17.3 million in the third quarter 2010. The increase was primarily due to increases in office and travel expenses related to new centers opened during
SOURCE Concord Medical Services Holdings Limited Copyright©2010 PR Newswire. All rights reserved |


text:
New Mexico's 2015 Legislature is in progress, with the first Republican controlled house in 52 sessions. As such, there is cause for concern regarding reproductive choice issues as three anti-abortion bills are about to be introduced on the floor. On Jan. 29, more than 100 community...
Holiday Glow
posted by Charlotte Martinez
If you're looking for some Holiday adventures this month, two luminous and art-influenced spots to visit are Glow: A Winter Lights Event at Santa Fe's Botanical Garden, running Dec. 4-Jan. 3 on Thursdays-Saturdays 5-8 p.m. and Saturdays 5-9 p.m., and the twinkle-lit open house events at Madrid, an artist's destination on Turquoise Trail National Scenic Highway. On opening night, Dec. 4, Public Relations Director Fran Cole admires that along with the hundreds of holiday light fixtures illuminating Santa Fe's Botanical Garden, the nearly full moon adds its own ambiance. "Did we order that or what!?" she says. For the month of December, Cole...
The Maya Spectra
posted by Amanda Tyler
Jackalope sits down with musical group The Maya Spectra to discuss the release of the band's debut CD, The Music Box, in this audio visual interview.
Finding the Right Tattoo Shop
posted by Jen Hanson
Getting a tattoo is a mighty decision, as is choosing a place that fits you best. Ultimately, it begs the question: what should I look for?
HEC set to open
posted by Charlotte Martinez
Since January, those attending SFUAD, Santa Fe High School or running on De Vargas Middle School's track have watched construction at the corner of Yucca Street and Siringo Road transform a vacant lot into the 34,000 square-foot, two-story, energy-friendly structure it is today. The...
Stand Down 2014
posted by Luke Montavon
On Oct. 24-25, Santa Fe University of Art and Design opened its doors to homeless and veterans at risk in Alumni Hall, where an annual two day Stand Down was held by the Santa Fe Veterans Center in cooperation with Adventist Community Services. According to the Santa Fe New Mexican, roughly...
Shuttle Muddle
posted by Luke Henley
It is 8:29 p.m. on a Saturday night and the shuttle driver waits diligently for any more students to arrive for their free trip downtown. Right on the dot of 8:30 p.m., it is clear that I will be the shuttle's only passenger. The ride goes along smoothly down Cerrillos Road and after a few...
posted by Adriel Contreras
Jackalope talks with the movers and shakers behind SFUAD's Necessities store.
Some Girls Q&A
posted by Nick Martinez
Some Girl(s) opens Oct. 17, so Jackalope sat down with two of its leads, senior Jade Scott Lewis and senior Shenyse Harris, to discuss the show, playing unlikable characters and favorite recreational activities. Jackalope Magazine: Tell us a little bit about Some Girl(s). Jade Scott Lewis:...
New Provost in Town
posted by Nicholas Beckman
Jackalope Magazine checks in with SFUAD's new and interim provost, Debra Tervala, about her plans and thoughts for the school.
New Mexico Actually
posted by Charlotte Martinez
In celebration of New Mexico Archives Month, on Oct. 2, employees of the State Records Center and Archives coordinated a special topic forum, "Documenting New Mexico's Folk Traditions at The Screen.
Sunday Night Sound
posted by Luke Henley
"This is a really great way to put off your homework for Monday," said Greg Bortnichak as he poised his fingers across the fretboard of his cello. Bortnichak makes up one half of Teach Me Equals along with Erin Murphy, a duo from Florida that brought their blend of classical instrumentation...
Hobby Lobby Protest
posted by Nicholas Beckman
Protesters gather at Santa Fe's Hobby Lobby to denounce its policy on reproductive healthcare for women.
Day in the Life: Federico Barela
posted by Sandra Schonenstein
As students, we take for granted that everything at the university has to work, be clean and organized. It is easy to forget that there are people who every day keep this university going and clean up the messes left behind. One of them is Federico Barela, a humble and laughing man from Chihuahua, who has been working here for three years. Besides working at the university, Federico Barela also works as a gardener after his shift at SFUAD finishes at 5 p.m. He also has three kids and a wife who he sees after working all day long. Usually the family sits together—along with coworker and friend Alfredo Amaya—and enjoy a self prepared meal...
SFUADcast: Hamilton ...
posted by Nick Martinez
Entering his senior year, Hamilton Turner has a lot on his plate. Between a full class schedule, directing a show and Underwear Society—the student run sketch comedy group—Turner has hit the ground running. Turner recently sat down with the SFUADcast to talk about his upcoming projects. Last...
SFUAD Shines at AHA
posted by Zoe Baillargeon
A variety of SFUAD students showcase artistic talents at this year's AHA Festival of Progressive Arts.
Gritamos Por Mexico
posted by Adriel Contreras
This past Monday, Sept. 15, a celebration took place on campus at the Quad. Upward of 30 or 40 people attended throughout the night, a familiar scent in the air of fried beans, cheese and burning coals on the grill in anticipation of steak, onions and tortillas. Memories meld with a night as I realize that a lot of the people around me are experiencing this culture with fresh eyes. Historically speaking, Sept. 16 marks the day on which Mexico as a country fully succeeded from Spanish rule in the wake of Napoleon's invasion of Spain and imprisonment of then King Ferdinand VII. The 15th was the commencement of the celebration, capped by...
Ready to Ride
posted by Luke Henley
SFUAD students will soon have access to free transportation downtown, following the Santa Fe City Council's Sept. 10 approval of a pilot shuttle project. The program builds on the three-day Night Wave event held last summer. Night Wave was intended to provide a model for what project director...
SFUAD Fiesta Float celebrates history of school
posted by Zoe Baillargeon
There are few greater ways to kick off a school year than with a parade. Every year in early autumn, the city of Santa Fe mobilizes around its most cherished of local traditions, Fiesta. Originally established in 1712 to celebrate the Spanish re-conquest of the city, the Fiestas de Santa Fe may have a religious overtone, involving several masses throughout the week, but perhaps most beloved are the ritualistic burning of Zozobra, Desfile de Los Ninos, or as it is affectionately known, the Pet Parade, and the Historical/Hysterical parade, a salute to Santa Fe's past and current quirky citizens. This year, the broiling Sunday afternoon was...
Q&A: Rumelia
posted by Sam Podio
Rumelia is a contemporary Balkan folk band made up of four women based in Santa Fe, NM, a couple of whom have a history with the previous College of Santa Fe. Band member and SFUAD Contemporary Music Program instructor Deborah Ungar spoke with Jackalope about Rumelia.
Tales From The Trenc...
posted by Sara Malinowski
Outside Magazine Associate Editor Jonah Ogles visits SFUAD to talk to Glyph students about the magazine, freelancing and having a writing career.
Unbowed, Unbent, Unbroken
posted by Miranda Bass
By midnight the line already had wrapped around the building. My group was the second in line for the Game of Thrones Season 4 early premiere, beaten only by the eight or so people crazier than us who arrived at 10 a.m., waiting over 24 hours in line. We arrived at 8:30 p.m. that night and we thought we were crazy for getting there even that early. However, for those wanting to claim one of the sixty-some remaining coveted seats, arriving after about 4 or 5 a.m. was already too late.
First Principles
posted by Ash Haywood
Nicholas Chiarella and six local artists visited Mary Olsen's 6th grade art classes at Wood Gormley Elementary in February to collaborate on site specific installation and architectural intervention.
posted by Nicholas Beckman
"Don't let her death be in vain" read the signs of family, friends and concerned citizens who rallied outside the First Judicial District Court April 11 to raise awareness for the fatal shooting of Jeanette Anaya by New Mexico State Police on Nov. 7, 2013.
Mireya Ferro Talks Dreams
posted by Bego Aznar
Mireya Ferro is an international student from Spain. She is currently studying graphic design, but her true passion has always been performing arts. Even though she has not been able to pursue this dream in the past, she feels that SFUAD has given her enough confidence to give it a try. In this interview, she discusses the importance of following one's dreams and fighting for what truly makes one happy.
Coming Attractions
posted by Charlotte Martinez
This weekend, check out Le-Weekend, winner of Best Film in the 2013 British Film Awards, as well as other offerings April 11-17 at The Screen.
Go Here: Counter Culture
posted by Sandra Schonenstein
Go Here, a semi-regular feature highlighting venues in Santa Fe for SFUAD students. This week: the popular Counter Culture Cafe on Baca Street.
The Lyons
posted by Dana Murrell
When a play opens on a man's hospital deathbed there isn't a transparent opportunity for comedy readily available. In a different work, perhaps, the undeniably grim theme of death would have been spun into sugar by the power of love or given supposedly weighty significance by various characters' profound reflections on human mortality. But The Lyons, Nicky Silver's play centering on family dysfunction, which opened on March 27 at the Santa Fe Playhouse and will continue to run through April 13, isn't a play about people with delusions of idealistic outcomes.
An Aural Arrival
posted by Ash Haywood
On the evening of March 26, Radical Abacus showcased the talents of electronic soundscape artists Geological Creep, Gossimer, and SFUAD's own Angelo Harmsworth.
Hundreds protest ABQ shooting of James Boyd
posted by Luke Montavon
Jackalope Magazine covers the protests over the Albuquerque Police Department recent shooting of a homeless man.


text:
Yesterday, I found this unique antique brass lamp at an estate sale. It's very heavy! I thought it had some very unique design elements to it. I've never really seen one like it. It is stamped M.S.L.C. on the bottom which stands for Mutual Sunset Lamp Company. This company was based out of Brooklyn NY. I've learned that the famous furniture and industrial designer, Gilbert Rohde, designed lamps for M.S.L.C. I haven't been able to find very many of his lamp designs that he did for M.S.L.C. but the ones that I have found, seem to carry some similar characteristics to this one. I was hoping someone here is more familiar with this designer or lamp company, that could help me determining if it's a Gilbert Rohde designed lamp. Or maybe someone knows of an expert in this field? I do think it's beautiful regardless of whether Rohde designed it or not. Thanks for your input in advance!! The last photo is a confirmed Gilbert Rohde designed S.M.L.C. lamp. |
Follow-Up Postings:
Maybe. It doesn't look much like his more famous, Deco-styled designs. Was the shade original? I'd guess it was made as a torchiere. I've linked to a Worthpoint entry that you've no doubt already seen. |
Here is a link that might be useful: Worthpoint
- Posted by palimpsest (My Page) on Fri, Sep 3, 10 at 17:23
The glass shade looks like a replacement. They still make them in that particular shape. The original glass shades would more likely have been some kind of a bowl shape with a flared top. They made floor lamps that were meant to carry a cloth shade just as your example with the shade sitting on the bowl at least into the end of the 1950s. They often held a mogul base light bulb which is 39mm across the threads unstead of 26mm. |
Gorgeous lamp - great find! |
- Posted by caseyandmelody (My Page) on Tue, Sep 7, 10 at 20:02
I agree that this particular lamp looks somewhat different from Rohde's more familiar deco styled designs, but I can also see some striking similarities. When I first saw this particular lamp, its (for lack of a better term) "stacked finials" at the base of the lamp, rise over 21" off the ground. I've never seen anything quite like it before. It's very unusual! I also think the saturn like design element near the top of the lamp is very deco/industrial age looking. The only other similarly designed lamp that I've ever seen like this one, is the one that I posted at the bottom. It's a M.S.L.C. lamp designed by Gilbert Rohde. I have also learned from a source that in the 30's, Gilbert Rohde designed over 35 different lamps for Mutual Sunset Lamp Co., but many were undocumented. I have a sneaking suspicion that this is one of them. I have seen other M.S.L.C. lamps but they are very "traditional" looking. Unlike this one. Maybe this is going to be one for the history detectives! ;) |
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Acer's Android Response to the iPad Mini
NEW YORK ( TheStreet) -- This is a review of the Acer Iconia A1. No, this is not a steak sauce. It is an Android tablet that's trying to mimic the form factor of Apple's (AAPL) iPad Mini. It's $199 and I don't recommend it for one reason: The crummy display.
The Acer Iconia A1 is very close to being a copy of the iPad Mini. It's got 7.9 inch display with 4x3 aspect ratio, and has a similar (low) screen resolution. On the plus side, the Iconia A1 has HDMI connector and MicroSD slot.
On the downside, it is thicker, is a bit slippery and doesn't feel like a high-quality build. Most importantly, the display is terrible. The viewing angles are the worst I've seen and the display is dim.
Comparing almost any web page, text, email, whatever with another tablet is not a flattering comparison. The Iconia A1 simply looks worse.
On the upside, the Aconia A1 has decent Android 4.2.2 software that feels mostly like a Nexus device. This means that it's got the easiest setup in the business, and has very little bloatware. It doesn't get much easier than this. Your need for tech support should be zero at all levels of ownership. Let me make a series of comparisons to illustrate how the $199 Acer Iconia A1 matches up with some alternatives you may have had in mind: 1. Apple iPad Mini: $199 vs. $329 for the iPad Mini is a big percentage gap, but I would argue the iPad Mini is a vastly better device. The quality of the screen is like night and day. In addition, the device has a different quality build, and it's thinner and shaped better. You can also pay another $130 and get the iPad Mini with embedded LTE for use on several of the major mobile network operators. 2. Asus Nexus 7: This device is about to be replaced any day by a Nexus 8 or whatever it will be called, but suffice it to say that the Asus Nexus 7 already blows the Acer Iconia A1 out of the water. Let's count the ways: A. The screen. Comparing anything side by side, it's not a close call. The Nexus 7 has a slightly smaller screen, but everything appears sharper, brighter, and doesn't suffer from the narrowest viewing angle.Check Out Our Best Services for Investors
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I'm ashamed to admit this, but I was watching Oprah at work the other day (hey, we only get a couple channels, okay?), and there was a story of a teenage girl who opened the door to her garage, and a bear was just outside the garage (garage door open, I guess). She shut the door, but the bear broke it down, saw the girls' mother and decided to eat her. The girl tried distracting the bear and punched it, but it was petty focused. She tried to get a gun but couldn't remember the combination for the vault. So she does the next best thing, opens the fridge and gives the bear lunchmeat. I'm not sure how the rest of it went, but mom got pretty messed up, but lived.
Bears in Cleveland? I don't think I'd beleive it if I heard from any journalist but Oprah herself.