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Cardiovascular Disease
Within the cardiovascular space alone the forecasted economic burden on society for medical care is expected to rise substantially. Cell therapy offers the potential of alleviating much of the burdens of these chronic diseases in a cost-effective way.
- It is projected that by 2030, 43.9% of Americans – approximately 139 million people – will have some form of cardiovascular disease. Between 2012 and 2030, total direct medical costs of cardiovascular disease are projected to increase from $396 billion projected to $918 billion. Real indirect costs – due to lost productivity – for all forms of cardiovascular disease are estimated to increase more than 58% from $183 billion in 2012 to $290 billion in 2030. The combined costs are expected to increase to more than $1.48 trillion by 2030.
AMI (Heart Attack)
AMI patients, one of the target populations in our Ischemic Repair Program, are at significant risk of downstream adverse events including chronic heart failure, re-current AMI, significant arrhythmias, premature death or acute coronary syndrome. Treatment of these patients post-heart attack represents a significant financial burden for many managed care programs. We expect that this burden will increase as the "baby boomer" population ages. AMR-001, if approved for this subpopulation alone, could provide significant pharmacoeconomic benefits by preventing downstream cardiac adverse events.
- Acute myocardial infarctions ("AMI") are the sixth most expensive condition treated in U.S. hospitals, with a national hospital bill of more than $37 billion annually.
Chronic Heart Failure
An additional and related potential application for AMR-001 includes chronic heart failure (CHF).
- Chronic heart failure affects 5.7 million individuals in the U.S. alone. Each year, nearly 1 million people are hospitalized with CHF, of whom 30 – 60 % are "readmits." CHF is now a main or contributing cause of nearly 53,000 U.S. deaths each year.


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"I breathe, sleep, and have an obsession with hairdressing," admits seasoned stylist Susan Hardesty. Susan's passionate enthusiasm serves her well in the salon, where she draws from this intense dedication to transform hair with an array of styling services. She treats clients to luxurious scalp massages before snipping up new styles and taming frizz with conditioning treatments from premium product lines such as Kenra and Pureology. She also adorns hair with colorful feather extensions, lacy ribbons, and glamorous tinsel. To top it all off, Susan can expertly frame faces in both natural-looking and creative highlights, as she is particularly skilled at coloring treatments. The versatile beautician also extends her expertise to makeup, offering application services and makeup lessons that teach her clients how to recreate looks on their own.
Eyeliner can make you look youthful, or mature. It can balance the features, or throw off the face's symmetry and leave your look out of balance. These are just a few things aesthetician Jin Mi has learned in her 13 years applying makeup professionally. Her cosmetic skills have been a hit at New York Fashion Week, and her brow-shaping expertise has been featured in WAG magazine. Now in Orlando, Jin extends her know-how to beauty-seekers in need of makeup services, facials, and waxing.
Aesthetician Rachel brings out clients' best selves with an array of spa services. Hot-stone pedicures and spa manicures treat feet and hands to warm steam towels and aromatic oils, and facials and airbrush tans illuminate skin to bring out an inner glow. Waxes smooth over rough patches on the face, legs, or extra third leg, softening skin to complement its refreshed look.
Stylist Christina Duba doesn't always stick to the script when it comes to designing new looks. She often transcends the cul de sac of cutting and styling to invigorate strands with ombre color and keratin smoothing treatments. She also adds length to locks with hair extensions and revises eyebrows with expert waxing services.
When Kimberlea Isaac and Kelly Newton set out to start a spa, they made a commitment to the planet, to animals, and to their clients. When they concoct the products used in skincare, massage, and mani-pedi services, they do so by whisking organic and natural ingredients, making the products free of synthetic dyes, fragrances, and preservatives. Many of the items are chosen for their nonirritating qualities, and, just like the SATs, nothing has been tested on animals. Even the containers?which swaddle retail items in the onsite boutique?are friendly to the earth, and clients who bring in empties get a discount on future services. The rest of the packaging is recycled or recyclable, and printed with vegetable-based, biodegradable ink.

subset: commoncrawl


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Sounds like the Snowboarder Bandit was running a little low on cash after a wild weekend two in Coachella and decided he needed to pick up a little more spending money at the BBVA Compass branch at (get this) 420 S. Palm Canyon Drive, according to a story on MyDesert.com. He walked into the bank [...]
read more
Olivia Wilde and beau Jason Sudeikis leave their hotel after spending a weekend away together on Sunday (January 22) in Palm Springs, Calif. The 27-year-old actress and 36-year-old SNL funnyman were joined by Olivia's pup Paco! PHOT... Read Post
When we heard that Burton Snowboards was hosting a party at the Palm Springs Ace Hotel during Coachella we were kind of bummed that we learned about it on a Hollywood gossip site. Then we saw who showed up and it all made sense. Vam... Read Post
First there were the slew of "skateboard bandits" hitting banks, now police in Orange County, California are looking for someone they are calling the "snowboarder bandit," after a man robbed a Wells Fargo branch in Irvine, Californi... Read Post


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Physical Location
2486 Main Rd
East Pembroke, NY 14056-0190
Mailing Address
Po Box 190
East Pembroke, NY 14056-0190
Phone: (585) 762-8713
School Type: Regular
School Level:
Primary School
School Status: Operational
School District: Pembroke Central School District
County: Genesee
Location: Rural, Distant
Title I School: Yes
Students: 259
Teachers: 22
Student-Teacher Ratio: 11.8 to 1
Lowest Grade in School: Pre-Kindergarten
Highest Grade in School: 02
Students by Grade
Pre-K: 51
Kindergarten: 72
Grade 1: 66
Grade 2: 68
Ungraded Students: 2
Corrections to the school database are encouraged! School Edit Form.
Pembroke Primary School, NY
(< 0.1 mile) Pembroke Junior-Senior High School, NY (4.6 miles W) Pembroke Intermediate School, NY (5.2 miles WSW) Oakfield-Alabama Elementary School, NY (5.8 miles NNE) Oakfield-Alabama Middle School High School, NY (5.8 miles NNE) |
Robert Morris School, NY
(6.1 miles E)
New York State School for the Blind, NY (6.5 miles E) Jackson School, NY (6.8 miles E) Batavia High School, NY (7 miles E) Alexander Middle School-High School, NY (7 miles SSE) |
Genesee Christian Academy, NY
(4.3 miles NE)
Notre Dame High School, NY (6.1 miles E) St. Paul Lutheran School, NY (6.5 miles E) St. Joseph Elementary School, NY (6.9 miles E) St. John the Baptist School, NY (12 miles WSW) |
The Demographic Data for the 3,933 New York cities, towns, counties, ZIP Codes and Census Designated Places (CDPs) profiled in this gazetteer is updated annually. Last Update: July 1, 2014.
The ZIP Code maps and the data regarding the number of residential and business addresses in each ZIP Code are updated four times per year. Last Update: November 1, 2014.
The information on the 77,130 New York Physical, Cultural and Historic Features is updated six times per year. Last Update: December 2, 2014.
The School Attendance Zone Maps for 3,995 New York public schools are updated four times per year. Last Update: October 6, 2014.


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The Dreamliner is the cover star of the 30 April issue of Flight International to mark its return to commercial flight after its long grounding following battery fires. In a two-page cover story we look at how Boeing plans to implement its technical solution to the battery problem and hopes the fix will restore its tarnished image. We list where the grounded 787s are situated, in 17 airports around the globe. And our Comment looks at the questions that remain over lithium-ion batteries, noting that there is "an inescapable sense of unfinished business with the battery fire investigation".
Our main feature package examines Turkey's fast-emerging aviation and aerospace industry, with profiles on Turkish Airlines and Turkish Aerospace Industries, partner with Airbus Military on the A400M and with AgustaWestland and aspiring manufacturer of a number of its own military aircraft designs.
We also focus on US regional aviation, with pieces on the slow retirement of the Bombardier CRJ200 fleet and Embraer's revamped E-Jet family.
In the news section, there are reports from the MRO Americas show in Atlanta and Aero Friedrichshafen in Germany. Plus: how Eurocopter's departing boss thinks vertical lift commuting could be the solution to airport congestion and why CFMI believes its Leap-1A engine is still in a strong position to power the lion's share of Airbus A321neos, despite rival P&W's early lead.


text: Went here last week to have the CHI Balance Massage. I have always been curious about the Chi Spa in Cebu Shangri-la Mactan (for the longest time) and was lucky to have had the opportunity to finally see the place for myself. The facilities are great and I found it more personalized as compared to The Farm in San Benito.... More


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Plastic Pink Flamingos for Minnesota
Minnesota needs to take the lead by recognizing the value and esthetic beauty added to our state year round by designating the Pink Flamingo as the \"Official Plastic Bird\" of Minnesota. By declaring Pink Flamingos the \"Official Plastic Bird\" of Minnesota, we hope to stop the proliferation of needless local statutes outlawing the display of this bird.
Sponsored by average citizens of Minnesota.
Recent signatures
Leah Tutin, United States
8 years ago State: OR
Country: US
Comments: I have a 6' flamingo in my lawn and am showing the flamingo pride!
Sheila Harvey, United States
9 years ago -
Joseph Ritchie, United States
11 years ago
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So we brewed a Citra Pale Ale and it just so happened that it was our first beer to keg. We poured- literally 2 oz and it just stopped....... As if there was no beer to be had. We're wondering if something is clogged (this brew is rather chunky).. Or if there is something else Going on? We kegged at 30psi for 24 hours and then moved down to 12. It was about 4 hours after turning it down that we "sampled". Should we cut the pick up line in the keg or what?
Probably some hop particles clogging the line. The most likely spot for this to happen is the poppet. Cutting the diptube shorter probably won't help things any. Disconnect the gas, vent the pressure, pull the liquid QD off, and remove the post to have a look at the poppet. You might also pull the diptube out to make sure it's not clogged too since the post will already be off. Remove any clogs and try again. If it clogs up right away again, you might consider carefully racking it to another keg with a paint strainer bag or nylon over the end of the racking cane to filter out the large debris. For future reference, you really need to make sure most of the large debris is filtered out before kegging.
Probably a dumb question, but did you make sure the little in-line valve near the gauge was turned back on allowing gas to flow again after you adjusted the pressure? I've done that and poured a glass and only a few ounces came out because there wasn't any gas flowing into the keg. It was confusing for a minute because the gauge still showed 12psi
------------------- "A witty saying proves nothing." - Voltaire


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Taylor and Selena back together!
There is harmony once again with former besties Taylor Swift and Selena Gomez. There are talking again! Not only talking but also hanging out and making up for long lost time. They were seen hanging out together in New York city goofing around and making silly faces at each other. Could this be a sign of coming back to BFF status?


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Meanwhile, from the driver's seat, the most vivid visual is a thin, polished steering column aimed directly at your chest. You worry that, in the smallest of crashes, the column will harpoon your thorax, killing you long before the precious car's owner arrives on the scene to do the job himself. Either way, it's a scary thought -- especially once you hit the gas and find that the supercharged Type 51 is modern-car fast.
The straight-eight starts quickly, idles perfectly, and responds instantly to throttle inputs. It's blatty and crude, with nothing of the sweetness we've become used to from eights arranged in a vee. It sounds more like two four-cylinders mounted together (which, in fact, it is); unmuffled (which, in fact, it is); and punctuated with the enormous clatter of a Scintilla magneto, which is sticking through the firewall and mounted in the dashboard. The pedals are laid out in the correct-modern-arrangement, but even the skinniest driving shoes are too wide to depress only the gas pedal. You learn to twist your ankle and use the side of your foot to actuate it.
To the right, outside the cockpit, is the long metal shifter. The four forward gears are arranged in the usual H-pattern, but with first and third toward the rear of the car. With no plastic bits or cables between your hand and the gears -- and Bugatti's zero-tolerance policy for machined parts -- the shifter's action is perfectly precise. So, too, is the clutch pedal, which is easy to use despite having what feels like less than an inch of travel.
The suspension seems to go on break when bumps arrive -- especially midcorner ones -- and the cable-actuated brakes are horrifying, to say the least, but the Type 51's effortless torque and shocking grip means it'll easily keep up with cars seventy years its junior.
After a few hours exposed to the elements, you're dirty, stinky, deaf, wind-blown, sunburned, and covered in a carcinogenic film of discarded motor oil. The experience is such a sweet assault on your senses that all of your reference points are null and void. You have no idea even how fast you're going. When I pulled out a GPS on an open section of Highway 1 along the Pacific coast, I was certain the device would mock me, showing a speed attainable by bicycle. Instead, we were heading due south at 72 mph, and the Type 51 felt like it had more than 50 mph left in it. Which it did.
Although the Bugatti car had plenty of reserve, Bugatti the company, it would transpire, did not.


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Challenge Awards Overview
Thanks to generous support from our state partners, Wisconsin AAA and PeopleForBikes, Fire Up Your Feet will award more than $5,000 to Wisconsin schools during the October 1-31, 2014 Fire Up Your Feet Fall Activity Challenge.
Final Challenge Awards: Final Challenge Awards are calculated by the following formula:
Total number of students, parents/guardians and school staff that tracked during the Challenge period, divided by school enrollment.
1 $1,000 first place award
1 $800 second place award
1 $500 third place award
Other Challenge Awards
1 $500 PeopleForBikes Challenge Award: The school with the most bicycling minutes during the month of October will win a $500 award and package of bicycling products and discounts from partners.
4 $300 Regional Wisconsin AAA Challenge Awards: $300 will be awarded to the school in each of the following regions* with highest participation rate for the entirety of the challenge period. Schools in these regions that win any other Challenges awards, including the the overall state awards, are eligible to receive the Regional Award as well.
*Regions: Milwaukee Public Schools, Dane County, La Crosse County, East Central Region (Calumet County, Fond du Lac County, Green Lake County, Marquette County, Menominee County, Outagamie County, Shawano County, Waupaca County, Waushara County and Winnebago County)
1 $300 Fire Up Your Walk to School Award: Schools with a minimum of 25 walkers at the end of the Challenge will be entered into a drawing for one Fire Up Your Walk to School Award. We strongly suggest these awards be used for Safe Routes to School encouragement programming activities. Click here for tips and ideas to help get the word out about this award offering.
Weekly Challenge Awards
- Week 1: 3-2-1 Blastoff Award: Any school with 20 participants tracking at least one activity using the coordinator or individual tracker between October 1-7 will be entered into a drawing for one $100 award.
- Week 2: "Walk it Out" Award: In honor of International Walk to School Day, the school that tracks the most walkers between October 8-14 will earn a $100 award.
- Week 3: Old School and New School Awards: The school with the biggest increase in participation from the previous Challenge will win a $100 award. New schools participating for the first time with the most participants tracking activity between the beginning of the Challenge and October 21 will earn a $100 award.
- Week 4: Reflect and Reward $100 Drawing: Between October 22-28, participants are invited to submit a short paragraph about how Fire Up Your Feet has benefitted their school. All submissions will be entered into a drawing for a $100 award. Please send paragraphs to firstname.lastname@example.com.
More About Awards
Participation levels may be subject to change in order to ensure a fair and equitable process. Questions should be directed to firstname.lastname@example.com