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Solving a Logarithmic Equation with Multiple Logs - Problem 4
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One strategy for solving equations with multiple logs is to get them on the same side of the equation and combine them into one single log. From there, if you have log x=log y, then x = y and you can solve. Don't forget to check for extraneous solutions: whatever you put into a log function must be greater than zero!
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What to do while on a vacation in India
See the Taj Mahal: Known as the symbol of love, the Taj Mahal in India is a must see monument. The exotic architecture and the beauty of the Taj Mahal will surely make you to see more of the Taj Mahal. Enjoy the food: You will get to taste different types of food in India. Almost every state in India has its own specialty. The only thing you have to do is to taste the specialties and experience the food culture of India.
Visit Kerala: Known as the God's Own Country, Kerala, a state in Southern India is a must visit destination. Your India tour is incomplete without visiting Kerala.
India is a beautiful country - See why
India is a beautiful country. Just like the United States, it is vast and has many places that attract tourists. The following are some of the best tourist destinations in India.
Agra: The home to the beautiful Taj Mahal, Agra is one of the best tourist destinations in India. If you are fond of ancient architecture, then Agra is the place for you to visit while travelling to India.
Jaipur: Also known as the pink city, it is one of the best places for tourists to visit. It contains a lot of ancient palaces and monuments known for their ancient architecture and beauty. Kerala: Known as the God's own country, Kerala is also one of the most revered destinations for tourists. Known for its greenery Kerala is the best for nature lovers.
Goa: If you are fond of beaches, then Goa is the place for you visit. It contains a lot of beautiful beaches.
These were some of the tourist destinations in India. If you are planning to visit India, then these are some of the places, which you need to include in your itinerary.
The European Union for Travelers
Europe and Europeans have been known for centuries to hold several dialects and languages, Switzerland is a great example as they have 4 national languages. The diversity in culture makes Europe one of the top attractions worlwide for vacationers. Those who want to see many different cultures and habits, hear different languages and see different people in a short period of time should travel around Europe. The climate shifts, from North and cold atmosphere to Mediterranean weather as it's near the Mediterranean sea.
Hotels, foods, measure's are what to expect in the 21st century developed countries, where you can enjoy the culture and comfort in beautiful places that show you history in every glance. Europe is always pushing itself forward to be a better tourist location.
The Beaches of Goa - India's finest
Goa, India is one of the most revered tourist destinations. Filled with exotic beaches, wonderful architecture and hotels for all budgets, Goa is one of the best places that you can visit for a holiday tour.
The main thing do in Goa is to explore the myriad beautiful beaches, churches and structures. You can also go scuba diving and other water sports while in Goa. There are various other things to do while in Goa.
Goa has a wonderful nightlife filled with lots of parties and pubs. If you are a party animal and love to enjoy yourself to the fullest while on a vacation, then Goa is the place, which you need to visit. It is fun and filled with lot of excitement as well as other activities that will help you to enjoy your holiday or vacation to the fullest.

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Futurist and policy analyst Sonia Arrison has been studying the effects of new technologies on human life for over a decade. Sonia Arrison is the author of '100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family and Faith,' which elaborates on the impending "longevity revolution" and the accepted notion that the first person to live to 150 has likely already been born.
In this short but captivating talk, Sonia Arrison discusses the implications of a longer life cycle on everything, but it will specifically invoke a need to name the new, emerging life stages, such as "adultlescence," the period after adolescence but before adulthood that many millennials are finding themselves in now.


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Arthur Phillips is the internationally bestselling author of Angelica, The Egyptologist, and Prague, which was a New York Times Notable Book and winner of the Los Angeles Times Art Seidenbaum Award for First Fiction. He lives in New York with his wife and two sons.
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Company Overview of The Rockefeller Foundation
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Friends of NRA's second to last episode of the season is airing this weekend. If you have the Outdoor Channel or know someone who does, you should definitely check it out this Sunday. Below is a clip from the coming episode and look at what Matt and Jessie are up to.
Episode 9 - Left My Heart In Texas
This week, Matt invites Jessie to trek down to Texas and pay a visit to his family's ranch.
It isn't all leisure at the range, however, as Matt puts Jessie's pistol marksmanship to the test and challenges her to take down a whitetail with one.
Joining the two this episode are both of the hosts' inspirations to become NRA Members, their fathers.
Both Mr. Duff and Mr. Harrison are still active NRA volunteers and lend their experience to help out a local high school shotgun shooting team who competes all over the United States.
Friends of NRA airs on the Outdoor Channel Sundays at 10:00 PM EST.
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Women's Wilderness Escape Rec Shooting Sports Specialist Samantha Olsen's take on the NRA's Women's Wilderness Escape.
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Word Puzzle ArchiveSunday 10th February 2013 [Word Puzzle 2746]
The hidden word is made up of the letters : GJLMNOPSU What would you like to do with this puzzle?
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Good morning Taj Mahal!
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Glioblastoma multiforme (GBM) tends to occur between the ages of 45 and 70. This relatively early onset and its poor prognosis make the impact of GBM on public health far greater than would be suggested by its relatively low frequency. Tissue and blood samples have now been collected for a number of populations, and predisposing alleles have been sought by several different genome-wide association (GWA) studies. The Cancer Genome Atlas (TCGA) at NIH has also collected a considerable amount of data. Because of the low concordance between the results obtained using different populations, only 14 predisposing single nucleotide polymorphism (SNP) candidates in five genomic regions have been replicated in two or more studies. The purpose of this paper is to present an improved approach to biomarker identification.
Association analysis was performed with control of population stratifications using the EIGENSTRAT package, under the null hypothesis of "no association between GBM and control SNP genotypes," based on an additive inheritance model. Genes that are strongly correlated with identified SNPs were determined by linkage disequilibrium (LD) or expression quantitative trait locus (eQTL) analysis. A new approach that combines meta-analysis and pathway enrichment analysis identified additional genes.
(i) A meta-analysis of SNP data from TCGA and the Adult Glioma Study identifies 12 predisposing SNP candidates, seven of which are reported for the first time. These SNPs fall in five genomic regions (5p15.33, 9p21.3, 1p21.2, 3q26.2 and 7p15.3), three of which have not been previously reported. (ii) 25 genes are strongly correlated with these 12 SNPs, eight of which are known to be cancer-associated. (iii) The relative risk for GBM is highest for risk allele combinations on chromosomes 1 and 9. (iv) A combined meta-analysis/pathway analysis identified an additional four genes. All of these have been identified as cancer-related, but have not been previously associated with glioma. (v) Some SNPs that do not occur reproducibly across populations are in reproducible (invariant) pathways, suggesting that they affect the same biological process, and that population discordance can be partially resolved by evaluating processes rather than genes.
We have uncovered 29 glioma-associated gene candidates; 12 of them known to be cancer related (p = 1. 4 × 10-6), providing additional statistical support for the relevance of the new candidates. This additional information on risk loci is potentially important for identifying Caucasian individuals at risk for glioma, and for assessing relative risk.
Determining the molecular changes that underlie phenotypic distinctions is a major thrust of cell biology. More specifically, identifying the precise DNA alterations in the genes and regulatory regions that underlie predisposition, initiation and progression of tumors is a central theme of biomedical research. Understanding the molecular changes associated with initiation and progression requires tissue samples from the tumor itself which are often difficult to obtain, as well as from a suitable control population. On the other hand, understanding molecular changes associated with predisposition requires only genomic DNA (e.g., from white blood cells) from the target and control populations, which can be obtained relatively readily. In this manuscript we focus on the latter, since that is where the preponderance of available information is. The methods can, however, be easily extended to the study of somatic genomic associations as control tissue samples from the brain become available.
Identifying predisposition involves (i) identification of the approximate genomic location of a change correlating with phenotypic distinction, which is usually done by finding correlative single nucleotide polymorphisms (SNPs), followed by (ii) the identification of genes or promoters in strong linkage disequilibrium with the SNPs, i.e. those that are coinherited. Following this is (iii) a search for mechanisms, such as point mutations, deletions, and translocations, which can be carried out by sequencing identified genomic regions in a sufficiently large number of samples from affected and control populations.
Here we focus on identifying regions and genes that predispose to glioblastoma multiforme (GBM) (i.e. (i) and (ii), above) by conducting a genome-wide association (GWA) study. A number of such studies have already been carried out for GBM and, as is typical for such studies, very few genes have been consistently identified across different populations [1,2].
The Cancer Genome Atlas (TCGA) samples
To identify risk variants for glioma, we conducted a principal component-adjusted genome-wide association (GWA) study on The Cancer Genome Atlas (TCGA) [3] SNP data. TCGA contains 226 blood samples from glioma patients. Genotypes were determined using the Illumina 550 K HumanHap SNP Array. We eliminated all samples for which more than 5% of the SNPs were missing, and eliminated all SNPs that (i) were determined in fewer than 95% of the samples, (ii) had minor allele frequency less than 5%, or (iii) had a Hardy-Weinberg p-value of less than 10-6. The procedure is outlined in Figure 1. In order to minimize the confounding effects of ethnicity-specific SNP frequencies in TCGA samples, we confined our study to European Americans, which was the predominant ethnic group in the data. Ethnicity was determined using a two-step screening procedure: (a) self-report of ancestry, and (b) computationally-assisted stratification. The latter was carried out using the EIGENSTRAT package [4]. After this screening, 179 TCGA samples remained. Of these, we used for confirmation only the 92 that were released after August 2009, since the majority of prior samples were included in the Adult Glioma Study (AGS) [1].
Figure 1. Subjects and single-SNP exclusion schema for genome-wide association studies.
Control Samples
Normal European American blood samples (n = 1366) were downloaded from the Illumina iControlDB (iControls) as the comparison group. After screening, 1306 control samples remained. Because the iControl has more than 3000 samples, we treat it as a background population for our TCGA analysis and use it as a control group (that is also used in AGS). Its treatment as a background population means that we would not expect the results to change with another sample from the same background population. As a partial check of this statement, we divided the glioma samples from TCGA into 2 independent samples, conducting a GWA analysis on each using the same iControl population. If the use of a single control created bias, we'd expect overlapping results. In fact the results have no overlap SNP at the 10-6 significance level (Additional file 1).
Additional file 1. Table S1. We divided the glioma samples from TCGA into 2 independent samples (P1 and P2), conducting a GWA analysis on each using the same i-control population. If the use of a single control created bias, we'd expect overlapping results. In fact the results are quite different.
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Statistical Methods
Association Analysis
Association analysis was performed using the EIGENSTRAT package, under the null hypothesis of "no association between the GBM and control SNP genotypes" based on an additive inheritance model [4]. The significance threshold p for association needed to be set stringently to allow for the large number of multiple tests in the GWA study. In particular, if we require that the probability of 1 or more false positives be less than 0.05, we must have 1-e-Np ≤ 0.05 or p ≤ 0.93 × 10-7 ≈ 10-7 with N, the total number of SNPs examined, taken as 550,000. At this level, few if any SNPs will be detected for typical glioma population sizes. The alternative is to accept a less stringent p-value, and to eliminate false discoveries by seeking confirmation in an independent study.
Rigorous methods for combining p-values from two independent studies were used. Since the AGS study has many more participants than TCGA, we used unequal weights and employed the method of Stouffer. In particular, the fused p-value is given by
where we take sample-specific weights (Wi) proportional to the square root of the "total number of individuals" and Zi = F-1(1-pi); F-1 (.) is an inverse standard normal CDF (cumulative distribution function). The false discovery rate is estimated as the fused probability multiplied by the total number of SNPs, which was 300,000 in the AGS study.
The procedure for calculating the fused p-values begins with lists of SNPs that have p-values of less than 0.001 in each population. We walk down this list, calculating a combined p value (equation (1)) for each pair, and accept all SNPs for which the false discovery rate (FDR) is less than 0.05 (or equivalently p12 = 0.05/300,000 = 1.7 × 10-7 ; see Table 1 and additional file 2). When p exceeds 0.001 in either population, P12 no longer meets the required threshold, and the walk stops. As a practical matter, the walk can be stopped at more stringent p values without changing the main conclusions. In particular stopping AGS at p = 10-5, and TCGA at 10-3, while requiring that p12 pass the genomic significance level (1.7 × 10-7), loses only 2 SNPs (rs12021720 and rs2810424), neither of which adds new genomic regions.
Table 1. Concordant SNPs recovered from TCGA and AGS data, and associated genes
Additional file 2. Table S2. The top 406 SNPs reported by Wrensch et al, (2009) with their AGS pvalues (P1), TCGA pvalues (P2), and Stoufer's combined pvalues(P12).
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eQTL Correlation
We use the coefficient of determination, R2, to identify the genes with strong eQTL correlation with the SNPs, identified by meta-analysis. R2 was calculated based on the correlation between gene expression level and SNP genotype, using the "SCAN: SNP and CNV Annotation Database" resource (http://scan.bsd.uchicago.edu/newinterface/index.html webcite). Genes/SNP combinations with R2 greater than 0.8 were considered to be strongly correlated.
Odds Ratio
The odds ratio for glioma susceptibility is defined and calculated as follows. For any pair or triplet of the above-mentioned risk alleles, define:
n11: number of individuals with the given risk allele combination in the glioma sample
n12: number of individuals without the risk allele combination in the glioma sample
n21: number of individuals with the risk allele combination in the control sample
n22: number of individuals without the risk allele combination in the control sample
Then the susceptibility odds ratio (OR) is given by
We identified 50 SNP pairs and 88 SNP triplets with significant odds ratios after ruling out combinations of SNPs that were within the same chromosome. Statistical analyses were implemented using R (v2.7) and PLINK (v1.07) [5]. Combinations with odds ratios greater than three, along with p-values, are shown in Table 2, which also shows that SNP combinations from chromosomes 1 and 9 are associated with the highest relative risk. Results for all possible pair and triplet combinations (including SNPs within 1 Mb of each other) of the 12 SNPs with OR > 3 and for which the risk allele occurrence frequency is > 0.05, can be found in additional file 3.
Table 2. Pairwise and triplet SNP combinations with odds ratios greater than 3
Additional file 3. Table S3. Pairwise and triplet SNP combinations with odds ratios greater than 3. Combinations of 12 Confirmed Glioma associated SNPs.
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Identification of Associated Pathways and Genes
Tumor initiation is associated with alterations in physiological processes that involve sets of genes and allelic variants in any of several such genes, not all revealed in a single population.
The standard method for identifying altered processes is a pathway enrichment analysis, which can be carried out using a single population [6]. In this case, pathways would be identified by showing that the number of significant SNPs/genes occurring in a particular pathway is above chance expectation. The procedure that we describe here extends this methodology to multiple populations. The assignment of a SNP/gene to a particular pathway using a single population is done using a significance threshold which is loose enough to allow multiple assignments from that population, but not stringent enough for an acceptable FDR in the single population. The FDR is brought down to an acceptable level, as described below, when both populations assign the same gene(s) to the same pathway.
The procedure begins as follows: (1) Identify SNPs having a p-value < 10-3 in either of the populations. (2) Identify genes that include these SNPs. (3) Assign the genes thus obtained to KEGG [7] pathways.
In any given pathway, genes identified by the AGS SNPs are generally different from those identified by our TCGA SNPs. Because the p-value is not stringent (p < 0.001), there is a reasonable chance that a number of SNPs, and therefore pathways, are false positives. We reduced the likelihood of false positives by determining whether, for a given pathway, the number of genes that are common to the two datasets is greater than expected by chance. In a particular pathway, if n1 genes are identified by TCGA data, and n2 by AGS (all at nominal p < 0.001), we calculate the hypergeometric probability of finding at least n genes (the observed number) common to the two sets. If we set an FDR = 0.05, we eliminate all pathways for which the hypergeometric probability exceeds 0.05 divided by the number of pathways to which genes were assigned.
Significant SNP candidates
Wrensch et al. [1] screened the Adult Glioma Study (AGS) population using p = 10-6 and inferred 13 SNPs, 3 of which were confirmed in the Mayo Clinic population at a multiple hypothesis corrected p-value of 0.0038 (0.05/13). In a similar fashion, we validated 4 of these 13 SNPs in the TCGA dataset: rs2736100 at chromosome 5p15.33, rs1412829 at 9p21.3, and rs7530361 and rs501700 at 1p21.2 (Table 1, boldface). The last two SNPs are reported as validations for the first time. The above confirmation-based method of correction used for multiple hypotheses is an approximation which gives primacy to one of the populations. The difficulty can be illustrated by first screening on the TCGA data set rather than on the AGS dataset. Using p = 10-6, two SNPs are found for the TCGA screen: rs11840214 in gene EFNB2 at 13q33 (p = 1.08 × 10-7) and rs1909486 at 8q24 (p = 4.3 × 10-7), and neither of these can be confirmed on the AGS population.
Joint rather than sequential analysis of data from two or more populations can increase the power to detect genetic associations [8]. In particular, using equation (1) in Methods, we identified 12 SNPs (Table 1), confirmed by AGS and TCGA at an FDR < 0.05, one of which was previously confirmed by Wrensch et al. [1] and Shete et al. [2]. Of the 11 remaining SNPs, 4 have been reported by Shete et al., and the remaining 7 SNPs are reported for the first time here. The 12 SNPs are distributed over five genomic regions, including chromsomes 5q15.33, 9q21.3, 1p21.2, 3q26.2 and 7p15.3. Two of these, 5q15.33 and 9q21.3, have been reported in previous studies [1,2]. The 12 SNPs are in strong linkage disequilibrium with 25 genes, 8 of which are known to be associated with cancer (indicated in boldface in Table 1). An additional SNP of interest is rs12341266 at 9q32, which has an FDR of 0.06 and is in the glioma associated gene, RGS3 (Additional file 2).
Odds ratio for combinatory SNPs
The analysis of TCGA and AGS identifies 12 SNPs, 7 of which have not been previously reported. One of the implications of identifying these additional SNPs is that the number of associated gene groups that can be used to estimate the odds ratio increases combinatorially. Consequently we can expect higher prognostic reliability for individuals possessing a combination of risk alleles, although at some loss of population coverage. We consider here all combinations of two and three SNPs, while constraining our choices to SNPs that are more than a mega-base (Mb) apart, in order to minimize redundant (disequilibrated) information. Specifically, the 12 SNPs are divided into 5 groups based on their chromosomal locations. Chromosome 1 has 5 SNPs clustered together within 1 Mb, and chromosome 9 has 4 SNPs within 1 Mb around genes CDKN2A, 2B. The remaining 3 SNPs are located on chromosomes 3, 5, and 7.
Genes Identified by Conserved Pathway Analysis
We identified 49 pathways (Additional file 4) that contain genes associated with loosely defined AGS or TCGA SNPs (p-value < 0.001). 13 of them meet the hypergeometric test at a p-value of 0.001 (an FDR of 0.05 divided by 49), i.e. pathways that are relevant to both populations. Each of the 13 pathways has one common gene from the two groups (Table 3). Five genes, FHIT, GABRG3, PRKG1, DCC, and ITGB8, occurred in more than one of these pathways.
Additional file 4. Table S4. KEGG pathways with SNPs (p < 0.001) from both AGS and TCGA studies. Boldface denotes pathways with significant genes that are common to both populations.
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Table 3. Pathways that contain significant SNPs (p < 10-3) inferred from both AGS and TCGA samples
Genes strongly correlated with SNP candidates
Eight of the 25 genes we identified are known to be cancer-associated. These include TERT [1,9,10], SLC6A18 [9], CLPTM1L [9,10], CDKN2A/B [1,11,12], SASS6 [13], ITGB8 [14], and MACC1 [15] (Table 1). Five of the genes, TERT, SLC6A18, CLPTM1L, and CDKN2A/B, have previously been shown to be associated with glioma by other GWA studies.
Our combined GWA/pathway analysis predicts four additional genes that are identified in the literature as cancer-related. We therefore predict 29 glioma-associated genes, 12 of them known from previous studies to be cancer-related. It is useful to evaluate the probability that as many as 12 cancer-related genes in a set of 29 would be found by chance. If we use the fraction of OMIM genes that are cancer-related as an estimate of the background frequency of cancer genes in the disease gene population, the probability that 29 genes include 12 cancer-associated genes by chance is 1.4 × 10-6. The fraction of OMIM genes that are cancer-related is 0.1 (750 cancer-associated genes in 7381 OMIM genes).
Each of the 8 cancer-related genes listed above plays one or more key roles in processes known to be altered during tumor initiation and development [16]. For example, MACC1 is a growth pathway regulator influencing angiogenesis and processes related to metastasis [15]; CDKN2A is a well-studied cell cycle regulator [12] and a known tumor suppressor whose loss results in a diminished ability to regulate growth and predisposition to cancer [11]; ITGB8 has been implicated in activities related to metastasis, including adhesion and migration [14]; and the telomerase enzyme (TERT) is linked to unlimited replication [1]. It is worth noting that CDKN2A, 2B are in strong linkage disequilibrium with rs1412829 at 9p21.3, which has now been identified in 3 independent studies and should therefore be considered an unusually high confidence cancer gene marker.
Aberrant processes
As noted in the Background, the identification of disease-associated SNPs by GWA studies tends to have low concordance when different populations are compared. An example is the above-mentioned verification in the Mayo Clinic population of only 3 out of the 13 SNPs identified in the AGS population. Our own results identified 12 SNPs based on a meta-analysis of TCGA and AGS. These include 5 of 14 glioma-associated SNPs that had already been verified by at least 2 other studies. There are many reasons for this, including possible differences in ethnicity and other less obvious stratifiers, and differences in sample size and background populations. We believe, however, that an additional reason of an entirely different nature is present which, roughly stated, is that different genes contribute to the same phenotype.
Recent evidence based in clinical epidemiology, computational genomics and various model systems [17-21] suggests that disease phenotypes emerge from dysfunction of one or more components of a functionally coherent gene module. Importantly, the dysfunctions (such as mutations in a gene or its promoter, post-translational modifications, multiple copy number variations, translocations) need not be the same, nor need they be in the same gene, in different individuals with the same disease phenotype. Since alterations in different genes in the same functional module (e.g. a pathway) can lead to the same dysfunction, low reproducibility rates in GWA studies -- aimed at identifying DNA loci having inherited alterations that predispose to complex disorders -- are not surprising. We might, however, expect greater concordance between populations if aberrant functional modules of genes were compared.
In fact we do find that some SNPs not invariant across populations appear in pathways that are invariant, suggesting that the SNPs, however different, are linked to genes that contribute to the same biological process, and that population discordance of SNPs can be partially resolved by evaluating processes rather than genes. Among the 406 AGS SNPs having p-value < 0.001, only 3% (12 out of 406) are invariant; i.e. have significant fused p-values. This contrasts with 19% of the non-invariant SNPs (75 out of the remaining 394) being in one of the 13 invariant pathways. In addition, as noted above, five genes, each appearing in two or more of these pathways, are invariant across the two populations.
ITGB8 was obtained by GWA study and discussed briefly above. Each of the other 4 genes also affects processes involved in cancer progression. More specifically, each has either been previously associated with cancer (DCC in the Online Mendelian Inheritance in Man (OMIM) [22]; FHIT and DCC in the Genome Association Database (GAD) [23]), or belongs to a gene family that has been previously associated with some form of cancer (the Kinase gene PRKG1, and the GABA receptor subunit gene GABRG3).
(a) FHIT (the fragile histidine triad gene) is believed to be a tumor suppressor, consistent with its deletion in a number of tumor types [24], including primary brain tumors [25].
(b) The crucial role of dysregulated signalling pathways in cancer development, and the frequent therapeutic targeting of kinases, makes association with the cyclic GMP-dependent protein kinase PRKG1 a plausible finding. This appears to be the first time this particular kinase has been associated with human cancer.
(c) DCC, the deleted colorectal carcinoma gene, has (as its name implies) been well studied and has been implicated in a number of cancers in addition to colorectal cancer [26]. DCC is an axon guidance receptor that responds to netrin-1 [27], and is a component of a pathway implicated in the regulation of angiogenesis, cell survival, apoptosis, and cell positioning and migration [28], all of which adds to the biological plausibility of this finding.
(d) The GABA-A receptor gene family encodes the major inhibitory neurotransmitter receptors in the central nervous system; changes in GABA-A receptor function have been implicated in diseases as diverse as alcoholism, epilepsy, schizophrenia, autism and Alzheimer's disease. Over 19 different subunit genes code for the pentameric GABA-A receptors, pharmacologically distinct forms of inhibitory neurotransmitter receptors that change their expression levels either during development or in disease [29]. Because of this complexity, elucidating molecular details of its role in many diseases is slow. The ligand GABA may be involved in metastatic prostate cancer [30], making association with aberrant forms of the receptor plausible, and the receptor itself has in fact been implicated in prostate cancer [31], and at least one of its subunits has been found to stimulate the development of pancreatic cancer [32]. This brief context, and the fact that glioma is also a disease of the brain, suggest that the association we find is biologically plausible.
In fact the finding that all 4 genes are plausibly associated with cancer may itself be significant. If we use the conservative estimate that two of the four (FHIT and DCC) are taken as cancer-associated because of their inclusion in GAD, we obtain 0.0015 as the probability of chance occurrence. We therefore expect that although the procedure we outline is perhaps more heuristic than rigorous, it yields highly suggestive candidates, which should be of interest to glioma researchers.
Odds ratios
It is evident that the greater the number of risk allele candidates, the greater the chance of identifying a potentially predisposed individual if all such genes are assayed. In addition, however, increasing knowledge of risk alleles affects not just the chance of identification, but the reliability, which will also increase to some extent. The reason for this is related to the chance of observing a combination of risk alleles in the same individual, and the fact that the number of combinations grows as a 2r, where r is the number of known risk alleles. As an example we calculated the odds for all doublet and triplet combinations for the 12 SNPs obtained by a meta-analysis of the AGS and TCGA populations, and list those with odds ratio > 3 in Table S3. Perhaps the most interesting result is the extremely high odds ratio (OR = 5) associated with the two alleles rs1412829 and rs4977756, both of which are in a cyclin dependent kinase.
In this paper we demonstrate that a meta-analysis of SNP data from TCGA which have not been previously analyzed, together with data from the Adult Glioma Study, identify 12 glioma-associated SNPs which represent 5 genomic regions -- 5p15.33, 9p21.3, 1p21.2, 3q26.2 and 7p15.3 -- three of these not previously reported. Of the 12 SNPs identified in this study, 5 have been previously reported and verified by other studies [1,2], while the remaining 7 are novel candidates. Eight genes known to be cancer-associated are included in, or are in strong linkage disequilibrium with, one or more of these SNPs. An additional 4 genes (PRKG1, FHIT, GABRG3 and DCC ) are identified by a combined pathway enrichment GWA analysis. In all we obtain 29 genes, of which 12 are known to be cancer related.
We have shown that the greatest relative risk occurs when risk alleles are present on chromosomes 1 and 9. Finally based on an analysis of the processes in which candidate genes are involved, we suggest that processes rather than genes are the most informative way to compare different populations, and have shown that such comparisons reduce discordance by approximately 19%.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
TY and CD participated in the design of the study. TY performed the statistical analysis. TY, MK, JH and CD conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
This work was supported by TCGA grant CA135882-02S1.
Wrensch M, Jenkins RB, Chang JS, Yeh RF, Xiao Y, Decker PA, Ballman KV, Berger M, Buckner JC, Chang S, et al.: Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
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Network CGAR: Comprehensive genomic characterization defines human glioblastoma genes and core pathways.
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Kang JU, Koo SH, Kwon KC, Park JW, Kim JM: Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer.
Cancer genetics and cytogenetics 2008, 182(1):1-11. PubMed Abstract | Publisher Full Text
Stacey SN, Sulem P, Masson G, Gudjonsson SA, Thorleifsson G, Jakobsdottir M, Sigurdsson A, Gudbjartsson DF, Sigurgeirsson B, Benediktsdottir KR, et al.: New common variants affecting susceptibility to basal cell carcinoma.
Nature genetics 2009, 41(8):909-914. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Bisio A, Nasti S, Jordan JJ, Gargiulo S, Pastorino L, Provenzani A, Quattrone A, Queirolo P, Bianchi-Scarra G, Ghiorzo P, et al.: Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma.
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Culhane AC, Quackenbush J: Confounding effects in "A six-gene signature predicting breast cancer lung metastasis".
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Boardman LA: Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer.
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Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
New American Standard (NAS) | New International Version (NIV) |
1 Now it came about in the days when the judges governed, that there was a famine in the land. And a certain man of Bethlehem in Judah went to sojourn in the land of Moab with his wife and his two sons. | 1 In the days when the judges ruled, there was a famine in the land, and a man from Bethlehem in Judah, together with his wife and two sons, went to live for a while in the country of Moab. |
New American Standard Bible Copyright © 1960, 1962, 1968, 1971, 1972, 1973, 1975, 1977, 1995 by The Lockman Foundation, La Habra, California. All rights reserved. (New American Standard Version - Holy Bible) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


text:
Wed, Jul 25, 12 at 23:36
Found this very small flower growing near the road. Height of flower stem (flowers along stem, no leaves to speak of) is about 6-8 inches. Flower is about an 1/8 inch across - very small. Plant leaves are at the base of the plant (approx. as rosette). Color is a bit off in this photo. More of a blue to blue-purple. Area is dry, very sandy. Bloom was early to mid-July. Cute little thing. |
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That is definitely it! Thank you very much for clearing up our mystery. |
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Do you have anything to add to this page? Have we made any mistakes... or do you ahve any additional information about Symphony In Slang? If so, we would love to hear from you. Please send us a quick note with your additions or corrections to this page, and we will make the corrections as soon as possible!
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Symphony In Slang
This page has been viewed 72 times this month, and 5164 times total.
- Theatrical Cartoon Pictures and Posters
- Featuring: John, Mary, St. Peter, Noah Webster.
- Originally Released on June 06, 1951.
- Originally Released Theatrically.
- Running Time: 6:45 minutes.
- TechniColor
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Below are comments about this cartoon submitted by people who have seen this show. Take a look and see what others have said about Symphony In Slang. We want to know what you think, too!! Feel free to share your own opinion- we do want to hear from you! You can add your own comments here.
Symphony in Slang
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This is a great cartoon to teach metaphors, similes, idioms, and hyperbole for the classroom - wish there were more video's like this to use in the classroom
0 of 8 people found this comment useful
Why is this cartoon in French??
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I love Symphony in Slang! But when I went to watch it from this site, it was all in French I think! Am I doing something wrong??
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Symphony In Slang
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After entering Heaven, John Brown said "What's cookin'?", "I got up with the chickens, to hunt a job." "He was short-handed." "I couldn't cut the mustard". "He gave me the gate." "I was... (read more)
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Your mom won't let you take the toaster apart, and your dad doesn't think it's a good idea to disassemble the computer and then reassemble it, and your sister won't let you see the inside of her favorite toy.
What's a kid to do?
Join us at the library as we take apart a variety of technological devices! Think you can make something better? Go for it!
This event geared towards kids 10-12.
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The Message (MSG) | New International Version (NIV) |
8 For the third test, the Devil took him on the peak of a huge mountain. He gestured expansively, pointing out all the earth's kingdoms, how glorious they all were. | 8 Again, the devil took him to a very high mountain and showed him all the kingdoms of the world and their splendor. |
Published by permission. Originally published by NavPress in English as THE MESSAGE: The Bible in Contemporary Language copyright 2002 by Eugene Peterson. All rights reserved. (The Message Bible Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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The problem that we face is the lack of cheap ,small battery holders
1.faber castle connecter sktechpens 2.button cells 3.some magnets 4.wire
take the cap of one of your connecter sketch pen and start putting button batteries into it and after putting all the batteries add 2 magnets on each ...
before each magnet add one wire each and you are done thanks for viewing
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Mon, Mar 17, 14 at 10:38
Follow-Up Postings:
a fabricator near me has a granite called golden beach as well. did you try the site for msi stone? |
Yes, I've looked at MSI, they have Golden Beach, but it is not the same. New Golden Beach is more white and grey than yellow. |
It looks quite a bit like astoria, at least in those pictures. Very pretty. |
You need to see this granite installed in your own home, with your lighting. You will probably be able to go in many different directions with this granite. What are your cabinets? |
msi has representation of older stones i think. i say this because their pics didn't match the actual stones i have seen. also i was at a granite yard this weekend and they had 2 typhoon bordeaux slabs, the older one was much darker than the newer one. new golden beach could be what they are calling the slabs coming out of the ground now also astoria doesn't have garnets splotches in real life (at least the slabs i have seen) and it more bland in color variation |
- Posted by athomesewing (My Page) on Mon, Mar 17, 14 at 12:22
ktj495 & athomesewing it does look a lot like Astoria. Thanks for your input! I found some pictures on marble.com when I searched for Astoria that show it in a kitchen with very similar colors to mine: http://www.marble.com/materials/granite/Astoria#1505 |
This post was edited by Mtkgal on Mon, Mar 17, 14 at 13:26
Nice kitchen! Are you planning to also do the 4 inch backsplash? I'm not a fan of it if you want to do a tile backsplash. For your cabinets, I would look for a cream toned tile. |
ellendi - no 4" backsplash, just tile. I think I am leaning to either a cream colored subway or maybe a travertine subway. Our counters get installed in 1 week, I'll begin my tile shopping once I see them in the space. |
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Case Foundation
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New Revised Standard (NRS) | New International Version (NIV) |
20 The time that Jeroboam reigned was twenty-two years; then he slept with his ancestors, and his son Nadab succeeded him. | 20 He reigned for twenty-two years and then rested with his fathers. And Nadab his son succeeded him as king. |
New Revised Standard Version Bible, copyright 1989, Division of Christian Education of the National Council of the Churches of Christ in the United States of America. Used by permission. All rights reserved. (New Revised Standard Bible Version Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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Fixed Blade KnivesBenchmade knives produce some of the finest fixed blade (non-folding) knives in the world. This selection is all USA made and the range includes many combat knives as well as survival and hunting sheath knives. |
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If the Dallas Cowboys thought last season was unpleasant, wait until they open training camp in Wichita Falls.
When the rough-and-tumble bikers known as the Bandidos gathered in San Antonio for the funeral of one of their beloved members, they swore a lot, drank a lot, defended themselves against the police and the public's misperceptions, and—amazingly— let a reporter observe the whole fascinating scene.
The state's public mental health system was woeful to begin with, and now legislative budget cuts have made it even worse. For thousands of mentally ill kids like Grant Williams, the only place to get treatment is a juvenile prison.
When you're underpaid, inexperienced, and overloaded with files detailing allegations of child abuse, there is a limit to how well you can do your job. Eight months in the life of an investigative team in the Travis County office of Child Protective Services.
Yvonne Stern knows that her husband, the wealthy Houston attorney Jeffrey Stern, had a steamy affair with a woman named Michelle Gaiser. And she knows full well that two years ago Gaiser hired a series of men to kill her. But she refuses to believe that Jeffrey was in on the plan.
A violent tackle in a high school football game paralyzed John McClamrock for life. His mother made sure it was a life worth living.
The young, tattooed men who are members of the Southwest Cholos, La Primera, La Tercera Crips, Somos Pocos Pero Locos, Mara Salvatrucha, and other Houston gangs are vicious career criminals who regularly rob innocent people in some of the city's most dangerous neighborhoods. They steal cars and break into businesses. They deal drugs on street corners. And they constantly wage war with one another.
Twenty-five years ago, in the wake of integration, he was the football star at my mostly white high school in Wichita Falls. Not much has gone right for him since.
It seemed like the perfect inside job: A respected cop conspires with his teller girlfriend to pull the biggest bank heist in San Antonio history. If they hadn't been so careless, they might have gotten away with it.
It was the most shocking crime of its day, 27 boys from the same part of town kidnapped, tortured, and killed by an affable neighbor named Dean Corll. Forty years later, it remains one of the least understood—or talked about—chapters in Houston's history.


text:
Only in tournaments like these does more than 100 minutes of soccer boil down to 1 1/2 inches.
That was the margin of victory for 5A Division II stalwart Goodyear Millennium in a 1-1 (4-3 edge in penalty kicks) game against Chandler Hamilton on Saturday in the Dobson Mustang Classic championship match.
The width of a soccer ball hitting the crossbar was the difference between Millennium sprinting around the Mesa Dobson High School field and Huskies goalie J.D. Zehring left on one end with his head buried in his hands.
Those same hands helped the Huskies to an early advantage in the penalty kicks, when he made the first save of the shootout.
The teams traded penalty-kick goals until Zehring, the fifth and final participant.
Trailing 4-3, the Huskies could have forced sudden-death penalty kicks, but Zehring's boot hit square on the middle of the crossbar and bounced away.
"That's the odd thing about soccer," Huskies coach Nick Markette said. "You can create that many chances for yourself and still lose."
Millennium got on the board late in the first half on a breakaway, but Michael Markette tied the score with 15 1/2 minutes left off a corner kick. Millennium appeared to be in good shape to deflect the kick away, but the ball hit the back of a Tigers defender and bounced forward into the net.
With two minutes left, Hamilton's Kerel Bradford nearly went end-to-end with the ball, but the speedy and skilled forward couldn't get a shot off when he reached the goalie box, and the teams played two 10-minute overtimes. Neither side allowed the opposition any significant chances.
Despite missing a penalty kick, Bradford and forward Tanner Clay both played well for the Huskies (11-2), who host Gilbert on Tuesday.
The Huskies gave themselves plenty of chances to win outright in regulation with 11 shots on goal, but they went wide or punched up and over the net in front.
Still, the Huskies have 4-0 start in power-point matches, and the unlikelihood of the team's two captains missing penalty kicks again feels remote enough that the Huskies aren't concerned going forward.
"We could have one of those (opportunities) go our way, but they battled and stuck with the plan and fought it out," Markette said. "I'm not at all disappointed with the effort.
"We have no easy games left. The real stuff is about to start."


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Gerda Stromberg Shyltan Glass Cut Butterfly Vase browse these categories for related items... All Items: Vintage Arts: Decorative Art: Glass: Scandinavian: Pre 1980: item # 1162106 Please refer to our stock # 2062 when inquiring.
Precious Treasures 11070 Applegate Circle Boynton Beach, Florida 33437 1-561-742-4079 Guest Book $45.00 |
$45.00 This signed vase has a butterfly and floral cut and is made of thick glass with a ground pontil. It was probably made around the mid century and is in excellent condition. It measures 5.5" high and 3.75" wide. The price is $45.00 plus postage and insurance. |


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The Norland Bed and Breakfast provides the finest in luxury accommodations. Unlike any other property on the prairies, the Norland is a rare 1910 Victorian mansion, architecturally restored with the finest materials imported from Europe. Private gardens surround the estate, beautifully secluded adjacent to the Gaol lake. The Norland boasts seven bedrooms, seven bathrooms, surrounded by five acres of private landscaped park. The Norland has expanded its venue to include a new ballroom that will accommodate up to 100 people for a sit down meal. This is an elegant and beautiful space with 80 of floor to ceiling windows with views to the garden for retreats, conferences, wedding receptions, and personal celebrations. All rooms have queen beds, TV and wireless internet, and most have a private phone, DVD or VCR player. Three rooms have ensuites that are equiped with heated granite or tile floors, and jetted or claw foot tubs.
Bed and Breakfast Rooms:
Studio Suites: Other galleries: *Alberta Tourism Levy may apply Room Rates |


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1. What is the best frozen pizza?
2. Your favorite thing to collect?
3. Do you consider yourself a good listener?
4. Do you like tv talent shows?
5. What is the longest you have ever gone without sleep??
Latest posts by Deb (see all)
- 7 Great College Football Players Who Never Conquered the NFL - September 26, 2014
- Team USA holds Finland to 2-point quarter, dominates FIBA World Cup opener - August 31, 2014
- Will Manziel Lead the Browns to the Promised Land? - August 10, 2014


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Love animals? Consider being a foster parent to a cat, kitten, puppy or dog until a permanent loving home can be found for them.
Kit Kat Rescue in Chandler is seeking volunteers, with the highest priority being foster homes for the animals it rescues. This 501(c)3 nonprofit group does not operate kennels, so the animals in its care must be placed in the private homes of volunteers. Through fostering you provide the pet with food, water and a loving place to stay until he or she is adopted at one of several Petsmart locations.
While the rescue is named "Kit Kat," it actually takes in many dogs too. And, it has many other volunteer opportunities available besides fostering. Volunteers must be at least 16; hours are flexible. Check out www.kitkatrescue.org for more information.
• A Helping Hand is our weekly spotlight on a volunteer opportunity in the East Valley. Find other ways to help at www.volunteermatch.org.


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A former three-sport athlete becomes a full-time father when he loses his job and becomes a stay-at-home dad. At first he doesn't know what he's doing and feels isolated from his friends, but it gets better. Spending time with his kids helps him communicate with his wife, he meets a new set of men who are also dads and he becomes and expert diaper-changer. "Being a househusband put this ex-sports jock in his place and showed me what it truly means to be someone's hero."
Tips For A Great New Year's Eve
Advice to make your New Year's Eve special, whether you're going out or staying in. Do drink Glogg; don't drink too much! Do know your party etiquette, don't spend too much time making appetizers. Do dress to impress, but don't worry if you're not going out!
'Julie The Tongue-Invader' And Other Tales On Kissing Well
A guy who loves kissing explains how he taught his girlfriends to kiss and love it, why making out is special and how to deal with a bad kisser. "I am an aficionado of the kiss. No other act is so simple and so intimate… A good kiss is a rapport enacted physically, like sex, but more erotic."
Dating Rules? This Dude Will Pass
When it comes to dating, there are so many rules. Rules, rules, rules. You can't call someone the day after you get her number. You're not supposed to wear a T-shirt with holes in it to your new flame's swanky birthday dinner. When someone says, "call me back—if you want to," the day after you have a "talk" about not "calling enough," maybe you should just call her back, even if you don't want to. If I just had a motorcycle and a leather jacket, I think things would be a whole lot easier. Those are rebel tip-offs. With a leather jacket, people know what kind of bad mamma jamma they are dealing with. And if, in your leather jacket, you wrote a poem about a girl, gave it to her, and then rode off on your motorcycle, she would be like, "Wow, he's so sexy," instead of being like, "Wow, ew." That's why I'm going to start smoking Rebel brand cigarettes. Maybe I should just get a pet snake or an electric guitar, too. Then they'll understand that rules don't apply to me.
Tales Of A Football Fan—And His Wife
My husband, James, is lying in bed, moping because his beloved Green Bay Packers just lost some football game. ?Frankly, I don't get it. Football is okay. I'm as happy as the next person to throw back a few beers and down greasy pizza on Sunday afternoon while watching men in tight pants run across a field. But the fact that James' mood revolves around weekly wins and losses? And that on any given Sunday for five months out of the year, his day can be made or ruined by a scoreboard? It boggles my mind.?? I don't understand why he's so upset. How can a game affect him so personally?? James stares at the ceiling and sighs. ??I'm about to remind him that he's not actually playing on the team he's so distraught over, but the lost puppy dog look he gives me makes me think better of it.??
We Broke Up Over Politics
I'm a social liberal, a product of my New England upbringing who thinks government can be run by professional Robin Hoods who redistribute wealth and carefully protect civil liberties. She is a fiscal conservative who thinks that the free market should be upheld at all costs. She's no war hawk, but she's no pacifist either. She thinks wars should be fought with hostile takeovers and marketing blitzes. I called her a robber baron, and she called me a socialist lite. They were like pet names. It's our luck that we met during the reign of Bush. We were equally disgusted by the ruling executive. Sure, we had different points of attack: I was horrified by the assault on civil liberties, while Karen was more concerned by the fiscal incompetence and costly doctrine of interventionism (she was, and still is, one of the few true isolationists I know). But we had a common enemy, and that allowed us to overlook the differences. But it was just that: an oversight.
Why Guys Control the Remote (& Other Stereotypes)
Why do men never seem to listen and always want to control the remote? One man sheds light on some of the most prevalent male stereotypes and explains that while they may not be fair, sometimes they hold a kernel of truth: "For me, having control of the remote combines two impressive skills; knowledge of TV programming and quick, hand-eye coordination in the form of button pushing. Wondering if Ace of Cakes reruns are on at 8:30? I can tell you yes, they are."
Do Successful Women Intimidate Men?
Over half of single women believe their success is intimidating to men. So, do women really intimidate men? We asked men what they thought and were surprised by their answers. Some men thought it was an excuse women use. Others said they never met a woman who intimidated them. Only a handful admitted it: "Honestly, when it comes down to it, all men have a little bit of both inside them, simply because of the historical dominance of males in society. Men inherit millennia years of social and hierarchical dominance and either knowingly or unknowingly have an irrational fear of losing their 'territory.'"
The Way She Looks: What Not to Say
It's the topic that every male in a relationship tries his best to avoid: What would you physically change about your partner? It turns out that "how do I look?" is a rather loaded question. Christopher Dickey explores the concept of body image and how it reflects on a relationship, and how flaws can sometimes be beautiful. Along the way he learns that "you look fine" is never an acceptable answer to any question.
How Scary TV is For Women: A Guy's Take
I never thought there was anything weird about television advertising until someone started leaving the TV on in my office during the day. The commercials that followed the overcaffeinated yammering of the morning talk show hosts gave me a glimpse into what it must be like to be a woman. And it scared the hell out of me. Most women I know don't live their lives in fear, but you wouldn't be able to tell that from watching the ads. On TV, women worry about stubborn stains. They face dilemmas about floor wax and carpet cleaners and toilet bowls and grape juice on T-shirts. The women I know have plenty to worry about, sure. They can't afford their apartments. They don't know how much to trust their boyfriends. They don't know how they're going to get ahead when the big dogs at work all wear suits and ties. But if any of them are watching daytime TV for a little escapism, all they have to do is wait for the commercials, and life turns ugly again, fast.
Do You Make More Money Than Him?
Dean Chandler gives advice to males on accepting a partner who outearns them.
Loving An Alchoholic Spouse
"When I think about her, I don't think: drunk. I think: runner. I think: artist. I see her dancing around our apartment, mouthing the words to Motown songs but miming disco moves. I consider how her voice deepens when she wants to talk about something serious, how she has no tolerance for indirect conversation or ambiguous language. I remember how my hands trembled when I met her. She wakes up in the morning in the middle of a conversation, asking, "What's the difference between a barnacle and a crustacean?" She has a long list of wacky endearments for me, including "my fresh coat of paint" and "my little prize-winning chicken," and she's in the very small group of people who think I'm fun--even when she's sober."
Why Guys Love Sports
From football to NASCAR, even men who can barely throw a wiffle ball are obsessed with sports. Yet, this fanatic phenomena isn't so crazy as it appears. One guy explains how for most men, the obsession with sports starts early, when they dreamed about being Nolan Ryan and Jerry Rice and grew when later their dreams of playing professional sports was cut short. Guy's, argues the writer, have had to settle for a lifetime of living vicariously through the wins and losses of their favorite teams: "We have been encouraged, if not pushed into, such pursuits, told to dream of becoming the next Tom Brady, LeBron James, or Derek Jeter. No one ever sends an eight-year old outside to play "write the great American novel" or "make an Academy Award winning film." If they did, we would have an entire generation of children arguing in backyards over who got to be Ernest Hemingway or Woody Allen instead of Manny Ramirez or Peyton Manning."
Why Do Nice Guys Finish Last?
Why is it that nice guys always finish last? So let's look into it with a deeper perspective. We all like being around nice people when it comes to friends and family but why doesn't it work when it comes to relationships? Why are nice guys always taken for granted? Learn some of the major reasons why women hate nice guys and what measures can be taken to stay away from that "Nice guy" image.
Why Is A Good Man So Hard To Find?
One man reveals where and how to find a good man, the man of your dreams. And guess what? It's not as hard as it sounds. Finding a good man boils down to defining "good" on your own terms, finding your passions and living a life that makes you feel happy. Join clubs and organizations around your hobbies and interests, live your life and don't worry too much about it. Guys are attracted to women who seem relaxed and happy. And keep an open mind. While you should know what a "good man" means to you, don't get so set in your expectations that you miss the opportunities right in front of you.


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Unbiased Reviews by Real People
Summary: So Im over at my friendly neighborhood Guitar Center the other day because I have to replace the case for my 1952 Gibson ES-5, which has completely fallen to pieces (the case, not the guitar) and was most recently a home for the itinerant ... read more
Summary: I was after the classic Gibson ES-335 overdriven rock tone but couldn't justify £2000 on a Gibson so set out to compare various ES-335 types for around £300-£400. Having compared a few including a Court Souce and Hofner Verythin (both ... read more
Summary: I bought my Transparent Cherry AS73 when they first came out. Back in 1975 I traded my Cherry Red 1963 335 for an Explorer and ever since I�ve been sorry for having trade-her in. I�ve played professionally for 20+ years and more than 40 overall; owned ... read more
Summary: I dropped by the local Guitar Center the other day looking for a 335 semi-hollow style guitar. Well, wouldn't you know it? They had just hung up on the wall some new Chinese AS73's. The appearance and price of just $299.00 caught my attention, and ... read more
Summary: I just bought my second guitar yesterday and went with the AS73 and couldn't be happier! I've been playing a hand me down acoustic for 20 years along with a Fender Telecaster I bought in 88 and wanted to upgrade. I have always liked the look of the ... read more
Summary: The Ibanez AS-73 is one of three initial jazz guitar models issued in recent years under the Artcore line. This particular model is inspired by the Gibson 335, but with its own unmistakable flair and style. I was originally given the AF-75 for Christmas ... read more
Summary: As a serious player and collector, this one caught my eye, it was only after a closer look i was amazed at the fact that this was made by Ibanez! Then the shock: The price!! WOW! I ripped it off the shelf and plugged it into the nearest Marshall stack in ... read more
Summary: I was helping a friend's son pick out his first electric guitar and wanted to show him some of the Epiphone Guitars I like. While he was playing the "Dot" I picked out for him to try, I picked up an Ibanez AS73. WOW! better action cleaner pickups,and ... read more
Summary: I have been playing guitar for about five to six (can't quite remember) years now and I have taken to forming a small collection. However, I am a college student and I don't have much of a budget. I have a Takamine EG540C, an Andreas model 52, a late 80s ... read more
Summary: It is extremely hard to get decent guitars for under $500 these days. So when I saw the Ibanez Artcore for only $299 at Daddy's Junky Music, for those familiar with the chain, I immediately fell in love with it. I plugged it into an amp, and just loved ... read more
Summary: I was going to the store to buy my new amp, but you gotta plug in a guitar so my friend hands me this one. Well, it took months to pick out my amp, but this guitar sounds so nice and looks so good it was a no-brainer. Yes you can buy nicer guitars. ... read more
Summary: This is simply an amazing guitar. When my guitar teacher showed it to me, I was immediately amazed. "Looks like an Epiphone but does it sound like one?" I thought to myself. I immediately plugged it into one of the store's Marshall stacks and I was ... read more
Summary: I picked up one of these for AU$640, and it's ridiculously good...the build and finish are superb, playability A1, great sound too. This is far better than I would've expected for a Chinese-built guitar...the finish in particular is a lot better than ... read more
Summary: Yes, it's an ES copy, but wait, it makes the Epiphone Dot look like piece of firewood, and compared to the Epi's price, sound like one too! The truth about it? Well, I was laughed at when I was going to buy it, and then given a cash offer once my Pro ... read more


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Despite being named Best Chiropractor in 2013 by readers of the Daily Herald, Doctor of Chiropractic Steve Baker and his staff at Baker Chiropractic and Accident Rehabilitation haven't let the praise go to their heads. Instead, they've kept their noses to the grindstone, scheduling everything from adjustments and physical-therapy sessions to massages and acupuncture treatments. The range of services can help alleviate an array of injuries, including dislodged discs from slouching in one's desk and whiplash from slouching in one's demolition-derby car.
The talented team at 56 West Salon and Spa helps clients look their best with hair, nail, and spa services. The stylists specialize in color and texture treatments and don't shy away from cutting men's and kids' hair. Not to be outdone, the nail technicians beautify fingers and toes with chip-resistant gel polish and colorful acrylic sets. With massage therapists and skincare experts also on hand, it's easy to plan a full day's worth of treatments at the spa.
Jessica Graff, the owner and manager of Prestige Salon & Spa, teamed up with Dr. Stanley Green to blend med-spa services, such as Botox, photofacials, and laser hair removal, with the relaxing and beautifying treatments of a salon. The experienced and personable staff— made up of a highly specialized team of stylists, nail technicians, aestheticians, laser technicians, and massage therapists—snips locks, sculpts nails, and lavishes bodies with massages alongside med-spa services. The unisex salon also helps men achieve well-groomed status with services such as haircuts, massages, and sports mani-pedis. Clients' eyes get in on the pampering at the salon's boutique, which carries designer bags, wallets, and aprons that keep your clothes clean while hosting dinner parties or refereeing a pudding-wrestling match.
Doctor of Chiropractic Joe Kepo'o, a certified Advanced 2 NAET practitioner, teams up with Dr. Daniel Luster to detect irritants through allergen testing and realign spines in chiropractic adjustments. The doctors consult with first-time visitors, discussing health problems and debating which species of dinosaur would have tasted the best.
Master Esthetics's staff keeps visages vibrant by administering 60-minute signature or acne facials. Recommended for dry, aging, or mummified skin, the signature treatment restores moisture to the face through gentle cleansing before beginning a process that includes two masks and a pore-cleansing steam session. The acne treatment pays extra attention to facial cleanliness, subjecting faces to two deep cleanses, extracting blackheads, and feeding the skin an essential blend of epidermal comfort foods. With as many as three facials at their disposal, customers can space treatments out—prolonging auras of effervescence for as long as possible—or redeem them all at once for a face that looks as fresh as it did the day it arrived in the mail in exchange for three Lucky Charms UPC codes.
Doctor of Chiropractic Joe Kepo?o puts his patients on the path of wellness with spinal adjustments, nutritional supplements, and natural allergy treatments. He sees patients of all ages and encourages whole families to come in together to tend to their health in unison.


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In her column, Minority Reports, Jennifer Vanasco analyzes how the mainstream media covers social minorities.
In the first obituaries about former astronaut Sally Ride, the news was easy to miss - buried at the end of the stories, after many hundreds of words about her achievements, was a variation of this sentence: "Dr. Ride is survived by her partner of 27 years, Tam O'Shaughnessy."
Many readers didn't understand, on first reading, that Tam was a woman. To the LGBT community, which had had no inkling that this American hero was in a same-sex relationship, the revelation was big news. But the question of what journalists should do when writing the obit of a semi-closeted public figure is one that comes up over and over again.
Chris Geidner, a political reporter at Buzzfeed whose beat is LGBT politics, was one of the first to focus on Ride and O'Shaughnessy's relationship (The other was the Broward-Palm Beach New Times).
"I think we live in a time when it does still matter when somebody comes out, as we've seen with Anderson Cooper and Frank Ocean," Geidner told CJR. "The reason I started looking into it is that initial tweets made it clear that people didn't know this about her."
When it became clearer to the general public that Ride had been in a longterm relationship with a woman, a spate of criticism was launched at the writers of the first obits, particularly The New York Times.
Andrew Sullivan, the Daily Beast writer whose blog hosted Cooper's coming out announcement earlier this month, called the Times's Ride obit a result of "homophobia." He wrote, "The NYT does not routinely only mention someone's spouse in the survivors section. When you have lived with someone for 27 years, some account of that relationship is surely central to that person's life. To excise it completely is an act of obliteration."
Achy Obejas wrote at WBEZ, Chicago's public radio station, that "No story was more awkward than The New York Times, which mentioned that Ride and her former astronaut husband, Steve Hawley, had decorated their bedroom with pictures of the moon 30 years ago but not, for example, that she and O'Shaughnessy had in the last few years co-authored several science books."
Clearly, the Times obit and others like it had touched a sore spot.
Denise Grady, the science reporter who wrote the Times obituary on Ride, said that she was worried about sensationalizing the issue. In an email to CJR, she wrote:
The question was, how much of a fuss should we make about this nowadays? How much a part of the story is it? What's appropriate? I think we wind up deciding case by case, because the circumstances vary and sometimes we have to make a call at the last minute. Personally, I would prefer to err on the side of appearing to have downplayed a person's sexuality, rather than look back and feel as if we had sensationalized it … . if you publish something crass or boorish or unsophisticated, you can't take it back. It's out there forever. And in an obituary, it may be the last word on an extraordinary person and a remarkable life.
Nevertheless, Grady added that, since O'Shaughnessy was a coworker in addition to Ride's partner (they co-wrote four books together and O'Shaughnessy is the chief operating officer of Sally Ride Science), "it would have been appropriate to mention" their work together in more detail. That did not happen at the Times because they found out that Ride had a partner very late, when they were up against a "desperate deadline."
There have been many follow up stories since that have delved into Ride and O'Shaughnessy's relationship, noted that the Defense of Marriage Act bans O'Shaughnessy from receiving Ride's NASA pension, or talked about the debate over whether Ride can be labeled a lesbian if she, as her sister said in Buzzfeed, "didn't use labels."
Labels or no, Ride's case seems fairly clear. The obit released by her family and published in Sally Ride Science included mention that O'Shaughnessy was her partner; Ride's sister, Bear Scott, who is herself gay, said O'Shaughnessy "was a member of our family" and that her sister "never hid her relationship with Tam." Though she wasn't out in public beforehand and was by all accounts a very private person, Ride came out posthumously and was clearly willing to have her relationship acknowledged.


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Saturday, September 20 Seahorse Key Lighthouse Tour, 11 a.m.-3 p.m. Special opening of the historic lighthouse with tours provided by Cedar Key Historical Society (CKHS) docents in period dress. Shuttle boats to the island available at City Marina, A Street. Additional information available at CedarKeyHistoricalMuseum.org.
Sunday, September 21
Cedar Key hosted its Second Annual Pirate Invasion last weekend. Coordinator Joe Catalono, of Bard Productions LLC. out of St. Augustine, said the event was about twice the size it was last year, with about a dozen different pirate crews from Georgia and all over Florida staging reenactments and pirate dramas throughout town. Catalono coordinated the event with the Cedar Key Chamber of Commerce and the Levy County Visitors Bureau.
Recent retiree from the US Fish and Wildlife Service Ken McCain was honored with a formal ceremony last week, receiving the National Wildlife Refuge Employee of the Year Award for 2014. Dignitaries from the U.S. Fish and Wildlife Service, its Refuge System, Florida Fish and Wildlife Conservation Commission, as well as friends and family were in attendance for the celebration.
A dangerous toxin-producing organism known as Karenia brevis from a red tide bloom first spotted in the Gulf of Mexico near the end of July has made it to Cedar Key, according to officials. In early August, the bloom was 50 to 80 miles offshore, and testing for the organism, which can affect the nervous system of people and animals, confirmed that it had only reached areas near Pinellas County. But the bloom, over recent months, has migrated with the wind, coming as close to shore as 5 to 30 miles between Dixie and Pinellas counties.
State officials are cracking down on lionfish cultivation. The Florida Fish and Wildlife Conservation moved Wednesday to prohibit the harvest and possession of eggs (other than for destruction) from the fish and have made it illegal to intentionally breed the animals, which are recognized as an invasive species that is bad for habitat and native Florida fish.
BBQ chicken and Turkey Shoot Suwannee River Shrine Club is having a Barbecue Chicken Dinner and Turkey Shoot on Saturday, Sept. 13, from 11 a.m. – 3 p.m. at the Shrine Club on SR 26, 1/2 mile north of Fanning Springs. A $7 donation includes chicken dinner with sides and a drink. All proceeds benefit the Suwannee River Shrine Club.
MoMS to open in Cedar Key
Celebrate the past with historical re-enactors this weekend in Cedar Key. See how pirates lived on land when ashore. Watch the epic battle that is certain to be played out on the shores of Cedar Key. Learn from some of the finest re-enactors on the East Coast.
Folks who want to be heard on this year's property tax and assessments bills will have their opportunity at 6 p.m. tonight (Thursday) when the Levy County Commission holds a public hearing at 6 p.m. in Courtroom A of the Levy County Courthouse. The purpose of tonight's hearing is to determine the final assessments for emergency medical service, fire, solid waste and roads. At the end of the hearing the commission will vote on the final assessments.
The Smithsonian Institution's highly anticipated Museums on Main Street (MoMS) is set to debut this weekend in Cedar Key. Hosted by The Cedar Key Historical Society, MoMS has been made possible by the Florida Humanities Council. The physical exhibit, which is titled, "The Way We Worked," explores how work became a central element in American culture by tracing the many changes that affected the workforce and work environments over the past 150 years.


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Such a dope logo!
Barrett Wood
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This T feels like it's made of organic cotton. It's quite soft and comfortable right off the bat. The owl is freakin awesome! You can't see it in the pictures, but the left seam from the hem to the end of the sleeve is stitched in red.
The fit is slim, not skinny. I'm 6' 165# and the medium perfect.


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Weekend game deals: XCOM Collection $15, Hitman Pack $11 and a new Humble Bundle
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It is only when we silent the blaring sounds of our daily existence
that we can finally hear the whispers of truth that life reveals to us,
as it stands knocking on the doorsteps of our hearts.
- K.T. Jong
Note from Liz: Thank you for a wonderful 2014! Check back in early 2015 for next year's retreats!
- Being curled up by a fireplace, mug of tea in hand, feeling at home surrounded by candles and poetry and an invitation to be present to this moment.
- Sitting beside someone who is quickly becoming a friend as you each share your creative dreams and brainstorm how to live them into reality.
- Giving yourself the gift of time alone to spend in whatever way you choose without any expectation of what you need to do next.
- Baking cinnamon rolls and fresh coffee as your invitation to begin your day.
- Giving yourself permission to walk in the woods or along the water, to play with paper and glue and color, or to simply sit in the quiet remembering yourself.
- Finding your way to laughter and silliness and the decision that staying in pajamas all day is the perfect one for you.
- Having the space to simply listen to what you most need and then realizing that you are surrounded by women who will support you as you make it happen.
This is the Be Present Retreats.
This is a place where you can show up as you, and you will be given the gift of time to rest and recharge so you can find your way back to you. This is your invitation to come along on a journey to rekindle your creativity and create space for you.
The Be Present Retreats are an invitation to pause in your life and gather in an intimate, creative community to explore, create, discover, and soak up the world around you. Each retreat includes creative play + adventures combined with stories and "being present" exercises to encourage awareness of this moment. At each retreat, you will also be invited to practice self-care to rest and nurture yourself as needed.
Over the last few years, Liz has hosted more than 15 events and retreats. Each retreat helps her to continue to shape and nurture the retreats to come.
Photo credits: The majority of the photos taken in the slideshow are by Vivienne McMaster with others by Liz Lamoreux and Beth Hutson.


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Delmarva Today
12:01 am
Wed November 9, 2011
Delmarva Today 09/09/11- Memories of 911
By Don Rush
Dr. Rosemary Thomas, vice president of University Advancement and executive director of the SU Foundation,Dr. James Hatley, a professor in the Philosophy Department,Timothy Kane, an SU alumnus,Gail Phillips, Social Work Department


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Douay-Rheims (RHE) | New International Version (NIV) |
17 (39-18) But I am a beggar and poor: the Lord is careful for me. Thou art my helper and my protector: O my God, be not slack. | 17 Yet I am poor and needy; may the Lord think of me. You are my help and my deliverer; O my God, do not delay. |
The Douay-Rheims Bible is in the public domain. (Douay Rheims Catholic Bible Translation Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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FLAT RUBBR BELT8.8X0.187X0.034 Flat Belts, I.C.: 8.8 , Thickness: 0.034 , Width: 0.187
Login Here to rate and review this product.
108-145 - Temflex 1700 Vinyl Electrical Tape
PVC insulating electricians tape 7 mil x 3/4" 60' roll UL listed, CSA certified for 176°F
TL00180 - Electronic Screwdriver Set and Cutters
A high quality seven piece precision screwdriver and side cutter set. The ergonomically styled handles are color coded with revolving tops, and the blades are manufactured from nickel, chrome molybdenum steel with hardened, black tips. Ideal for electrical termina...
42-800 - Flat Belt
8.72X0.031X0.125/ 221.5MMX70.5X0.8X3.2 Flat Belts, I.C.: 8.72 , Thickness: 0.031 , Width: 0.125
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