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Now showing items 1-20 of 224
Next PageAbstract: | Chronic musculoskeletal pain is a common health problem and a major cause for disability pension in Norway. Increased pain and fear related to general activity and exercise may be a barrier to rehabilitation of patients with chronic muscular-skeletal disorders.
The aim of the present research was to investigate the occurrence of activity related pain, and to explore its association with fear, psychological distress, self efficacy and pain (duration and distribution). The second aim was to explore how these psychological aspects and activity related pain associates with individuals' readiness to adopt a self-management approach to pain, and how patients described and explained such pain experiences. Data were collected by questionnaires and qualitative interviews with out-patients at a Physical Medicine clinic at the University Hospital of Northern Norway. Results showed that a majority of the participants experienced increased pain during activity. Pain related fear of movement/(re)injury was a unidimensional construct, which was statistically significantly associated with increased pain during activity, also among individuals without psychological distress. Participants with high levels of fear of movement/(re)injury and psychological distress and weak sense of (pain) self efficacy were more likely to report pain during activity. They were also less ready to take a self-management approach to pain. Activity related pain was described and explained as a complex experience with diverse meanings. Initial fear of pain was re-interpreted under the influence of time, learning and own experience. Participating in social life situations was an important incentive to stay active despite pain. |
URI: | http://hdl.handle.net/10037/2500 |
Abstract: | Akutt hjertesvikt, spesielt ved sirkulatorisk kollaps, er en dramatisk tilstand med høy dødelighet. Forekomsten av akutt hjertesvikt er økende og tilgjengelig kunnskap om sykdomsmekanismene samt medisinsk behandling er begrenset.De siste tiår har det vært en revolusjonerende utvikling i behandlingen av og overlevelsen ved iskemisk hjertesykdom og akutt hjerteinfarkt. Tilsvarende utvikling har det dessverre ikke vært i behandlingen av akutt hjertesvikt som er et økende problem assosiert med høy dødelighet. Formålet med dette prosjektet har vært å kartlegge epidemiologi, behandling og prognose ved forskjellige typer akutt hjertesvikt. For å øke den patofysiologiske forståelsen av sirkulasjonsregulering ved de mest alvorlige former for akutt hjertesvikt (kardiogent sjokk) har vi gjennomført observajonsstudier av biokjemiske responser og perifer karfunksjon i sykdomsforløpet. Prosjektet har vært todelt. Vi har først har sett på forekomsten av forskjellige typer akutt hjertesvikt og behandlingen som ble gitt ved medisinsk og kirurgisk intensiv avdeling ved UNN over en 2 års periode. Tross moderne behandling med bla tidlig revaskularisering døde ca 1/4 av pasientene under sykehusoppholdet. Dårligst prognose hadde de med kardiogent sjokk der nesten halvparten døde. De med lettere former for akutt hjertesvikt hadde meget dårlige leveutsikter i perioden etter utskrivelse og kun 50 % var i live etter to år. Mer utstrakt og tidlig bruk av mekanisk sirkulasjonsstøtte (hjertepumper) kan potensielt bedre overlevelsen hos de med mest alvorlig og behandlingsrefraktær hjertesvikt. Hos pasienter med kardiogent sjokk og alvorlig hjertesvikt etter hjertekirurgi er dårlig respons på konvensjonelle blodtrykksøkende medikamenter forbundet med spesielt dårlig prognose. For å kartlegge de underliggende mekanismene ved sirkulasjonssvikt spesielt mtp perifer sirkulasjonsregulering har vi målt perifer karfunksjon (endotelfunksjon), markører på systemisk inflammasjon og sirkulerende NO-blokkere (ADMA) under sykdomsforløpet. Tilstanden var karakterisert av en betydelig systemisk inflammasjon samt redusert perifer karfunksjon. Høye nivå av ADMA var assosiert med organsvikt og graden av hypoperfusjon. |
Description: | The papers and the appendix of this thesis are not available in Munin: 1. Hermansen SE, Hansen M, Roaldsen M, Muller S, How OJ & Myrmel T.: 'Utilization and outcome of coronary revascularization and valve procedures in acute heart failure : an evaluation based on the classification from the European Society of Cardiology', Interactive CardioVascular and Thoracic Surgery (2008) vol.7, no.5:833-838. Available at http://dx.doi.org/10.1510/icvts.2008.175067 2. Hermansen SE, Hansen M, Roaldsen M, Muller S, How OJ & Myrmel T.: 'How many acute heart failure patients need a ventricular assist device?', Scandinavian Cardiovascular Journal (2008) vol.42, no.2:118-124. Available at http://dx.doi.org/10.1080/14017430701819113 3. Hermansen SE, Hansen M, Muller S, How OJ & Myrmel T.: 'Endothelial function during open heart surgery' (manuscript) 4. Hermansen SE, Kalstad T, How OJ & Myrmel T.: 'Inflammation and reduced endothelial function in the course of severe acute heart failure', Translational Research (2011) vol.157, no.3:117–127. Available at http://dx.doi.org/10.1016/j.trsl.2010.12.002 5. Hermansen SE, Lund T, Kalstad T, Ytrehus K & Myrmel T.: 'Adrenomedullin augments the angiogenic potential of late outgrowth endothelial progenitor cells', American Journal of Physiology Cell Physiology (2011) vol.300 no.4, C783-C791. Available at http://dx.doi.org/10.1152/ajpcell.00044.2010 Appendix: Hermansen SE, Naesheim T, How OJ & Myrmel T.: 'Circulatory assistance in acute heart failure : where do we go from here?', Scandinavian Cardiovascular Journal (2009) vol. 43, no.4:211-216. Available at http://dx.doi.org/10.1080/14017430802715962 |
URI: | http://hdl.handle.net/10037/4622 |
Abstract: | Avhandlingen presenterer behandlingseffekt, bivirkninger og livskvalitet hos lungekreftpasienter som får moderne cellegiftbehandling. Pasientene med performance status (PS) 2 er etterpå vurdert separat.
Avhandlingens tittel er "Advanced non-small cell Lung Cancer – Effects of Chemotherapy and Impact on Health Related Quality of Life". Den ble forsvart for graden PhD 13.03.2009. På verdensbasis er lungekreft den vanligste kreftsykdommen og den som forårsaker flest kreftrelaterte dødsfall. I Norge dør rundt 2000 mennesker av lungekreft hvert år. De fleste pasientene har langtkommet sykdom og kan ikke kureres. Målet med behandling er forlengelse av livet og best mulig livskvalitet. Avhandlingen tar utgangspunkt i VING-studien som ble gjennomført for å undersøke om det var ulik overlevelse, bivirkningsprofil og livskvalitet forbundet med to ulike cellegiftkombinasjoner. Ca 40 % av pasientene med langtkommet lungekreft er i dårlig allmenntilstand ved diagnosetidspunktet. I avhandlingen vurderes nytte og effekt av behandlingen for pasienter med PS 2. VING-studien var en nasjonal multisenter fase III studie utgått fra Norsk Lungekreftgruppe. Fra september 2003 til desember 2004 inkluderte 33 sykehus over hele landet 432 pasienter i studien. Pasientene fikk tre cellegiftkurer med tre ukers mellomrom, enten vinorelbin/carboplatin, eller gemcitabin/carboplatin. De fylte ut livskvalitetsskjema ved studiens start, før hver kur og deretter regelmessig ved kontroller. Sammenligning av de to behandlingsalternativene viste at overlevelse og livskvalitet var den samme, men at behandling med vinorelbin gir mindre tiltakskrevende bivirkninger. Som en konsekvens av dette, ble cellegiftkombinasjonen vinorelbin/carboplatin standardbehandling ved langtkommet lungekreft i Norge. Undersøkelser av hvordan PS 2 pasientene tålte behandlingen, viste at disse hadde gevinst av behandlingen. De oppnådde bedring i generell livskvalitet og pusteproblemer, samt mindre smerter, utmattelse, søvn- og appetittproblemer. Man frykter at cellegiftbehandling er en for stor påkjenning for de sykeste, men disse resultatene tyder på at man i større grad enn tidligere bør tilby behandling til pasienter som ønsker det. |
Description: | Papers number 1 and 2 of the thesis are not available in Munin, due to publishers' restrictions:
1. Helbekkmo N, Sundstrom SH, Aasebo U, Brunsvig PF, von Plessen C, Hjelde HH, Garpestad OK, Bailey A, Bremnes RM; for the Norwegian Lung Cancer Study Group: 'Vinorelbine/carboplatin vs gemcitabine/carboplatin in advanced NSCLC shows similar efficacy, but different impact of toxicity.' British Journal of Cancer (2007) 97, 283-289 (Nature Publishing Group). Available at http://dx.doi.org/10.1038/sj.bjc.6603869 2. Helbekkmo N, Aasebø U, Sundstrøm SH, von Plessen C, Brunsvig PF, Bremnes RM; for the Norwegian Lung Cancer Study Group: 'Treatment outcome in performance status 2 advanced NSCLC patients administered platinum-based combination chemotherapy.' Lung Cancer (2008) 62, 253-260 (Elsevier). Available at http://dx.doi.org/10.1016/j.lungcan.2008.03.003 |
URI: | http://hdl.handle.net/10037/1823 |
Abstract: | Age-related macular degeneration (AMD) is an important cause of visual impairment and blindness worldwide. The number of people affected by the disease is expected to rise due to increasing longevity. Development of adequate eye care for these patients should be based on knowledge about the prevalence of AMD. Further, preventive measures are the best strategy for any disease. The aims of this thesis were to estimate the prevalence of AMD and examine risk factors associated with AMD. We described prevalence rates of AMD among Caucasian elderly participants from the Tromsø Eye Study, a population-based study in Norway. The overall prevalence of late AMD was 3.5 % among the participants aged 65-87 years old. Neovascular AMD outnumbered geographic atrophy. Symmetry between eyes was relatively low. Prevalence increased strongly with age. No significant sex differences in prevalence rates of AMD were observed. Refractive error was lower in eyes with late AMD than in eyes without late AMD. We then analysed relationships between traditional cardiovascular risk factors and AMD. Daily smoking was a strong predictor for the presence of late AMD. We found a significant interaction between age and sex for late AMD, suggesting that age may be a stronger risk factor for late AMD in women than in men. Higher systolic blood pressure, higher pulse pressure, infrequent physical exercise and overweight or obesity were in adjusted analyses associated with late AMD in females, but this was not observed in men. Based on our observation of sex and AMD, we studied associations between female hormone related factors and AMD. We found a significant inverse relationship between duration of lactation and late AMD. No significant relationships were found between late AMD and exogenous oestrogen exposure in the form of contraceptives or hormone therapy. Nor did we find an association between late AMD and onset, end or length of fertile years, bilateral oophorectomy or parity as surrogate measures. |
Description: | The papers of this thesis are not available in Munin: 1. Bertelsen G, Erke MG, von Hanno T, Mathiesen EB, Peto T, Sjølie AK and Njølstad I.: 'The Tromsø Eye Study: study design, methodology and results on visual acuity and refractive errors', Acta Ophthalmologica (2012), Online before print. Available at http://dx.doi.org/10.1111/j.1755-3768.2012.02511.x 2. Erke MG, Bertelsen G, Peto T, Sjølie AK, Lindekleiv H and Njølstad I.: 'Prevalence of Age-Related Macular Degeneration in Elderly Caucasians: The Tromsø Eye Study', Ophthalmology (2012), vol.119(9):1737–1743. Available at http://dx.doi.org/10.1016/j.ophtha.2012.03.016 3. Erke MG, Bertelsen G, Peto T, Sjølie AK, Lindekleiv H and Njølstad I.: 'Cardiovascular risk factors associated with agerelated macular degeneration: The Tromsø Study' (manuscript) 4. Erke MG, Bertelsen G, Peto T, Sjølie AK, Lindekleiv H and Njølstad I.: 'Lactation, female hormones and age-related macular degeneration: The Tromsø Study' (manuscript) |
URI: | http://hdl.handle.net/10037/5155 |
Abstract: | Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that predominantly affects young women. Knowledge of the processes underlying the development of autoimmunity as well as end-organ disease manifestations is limited. One of the major contributors to morbidity and mortality in SLE patients is the development of nephritis. Using a murine model of SLE we have characterized changes occuring within the kidney during the development of lupus nephritis. The results demonstrate qualitative and quantitative alterations in the collagen IV matrix within the glomerular extracellular membranes, associated with increased proteolytic activity and the activation of the Wnt signaling pathway. Co-inciding with these events there is a downregulation of renal Dnase1 expression, which is associated with the development of severe nephritis. These data identify major biochemical alterations within the glomerulus during development of lupus nephritis, offering new insight into the development and progression of the disease. |
Description: | Papers number 1, 2 and 4 of the thesis are not available in Munin due to publishers' restrictions:
1. Tveita A, Rekvig OP, Zykova SN.: 'Increased glomerular matrix metalloproteinase activity in murine lupus nephritis', Kidney International 2008 Nov;74(9):1150-8 (Nature Publishing Group). Available at http://dx.doi.org/10.1038/ki.2008.308 2. Tveita A, Rekvig OP, Ninomiya Y, Sado Y, Zykova SN.: 'Lupus nephritis is associated with a glomerular collagen IV isoform switch', Lupus 2009 Apr;18(4):355-60 (Sage). Available at http://dx.doi.org/10.1177/0961203308100842 4. Tveita A, Rekvig OP.: 'Alterations in Wnt pathway activity in serum and kidneys during lupus development', Arthritis & Rheumatism 2011 vol. 63 Issue 2, February 2011, Pages: 513–522 (Wiley-Blackwell publisher's restrictions), available at http://dx.doi.org/10.1002/art.30116 |
URI: | http://hdl.handle.net/10037/2898 |
Abstract: | In the presented work the bacterial family Vibrionaceae was used as a model to investigate bacterial diversity on a gene level and to analyze the underlying concepts of bacterial niche adaptation and evolution. For this, the genomes of a diverse dataset of 64 Vibrionaceae isolates from various environments and temperature zones were analyzed using existing as well as newly developed bioinformatics tools. By building the pan-genome of the investigated isolates, i.e., determining the sets of shared and unique genes of each included isolate, the genetic diversity of members of this bacterial family was analyzed. Also, the distribution of the determined pan-genome on the chromosomes of all completely assembled genomes included in this study was analyzed with focus on speciation and evolution of Vibrionaceae. In a subsequent study general adaptation strategies of cold-adapted Vibrionaceae were investigated using membrane proteins that are conserved among all investigated isolates. In summary, the results presented in this thesis highlight the variety of different evolutionary processes that contribute to the adaptation and speciation of bacteria in general and Vibrionaceae in particular. |
Description: | Paper 2 of this thesis is not available in Munin: 2. Tim Kahlke, Alexander Goesmann and Peik Haugen: 'The Vibrionaceae pan-genome hints at gene expression as the major driving force for unequal gene distributions on Vibrionaceae chromosomes' (manuscript) |
URI: | http://hdl.handle.net/10037/5248 |
Abstract: | Mannens testosteronnivå påvirkes av genetiske variasjoner i androgenreseptorens lengde selv om sammenhangen er beskjeden. Studier på celler har også vist at den vanligste androgenreseptoren lengden er den mest effektive. I studien Androgen receptor CAG og GGN polymorfier in vivo og in vitro har vi studert sammenhengen mellom genetiske variasjoner i androgenreseptorens lengde og testosteronnivåer samt risikofaktorer for hjerte- karsykdom (Metabolsk syndrom). Vi har også på cellenivå studert hvilken betydning variasjoner i androgenreseptorlengden har på reseptorens effektivitet og evne til å skape det androgene uttrykk. Vi har i våre studier vist at testosteronnivået hos eldre menn er assosiert med en økende lengde på androgenreseptoren. Assosiasjonen var dog beskjeden sammenlignet med for eksempel betydningen av overvekt som er kraftig assosiert med lave testosteron nivåer. Man behøver derfor ikke å ta hensyn til reseptorens lengde ved undersøkelse av lavt testosteronnivå hos eldre menn. Videre fant vi at menn med kortere variasjon av reseptoren hadde flere risikofaktorer for hjerte- karsykdom. Hva gjelder reseptorens grad av effektivitet, så ble dette studert på cellenivå. Vi fant at det var den vanligste, middels lange reseptoren, som var den mest effektive varianten. Dette ble senere bekreftet blant eldre og yngre menn med kjent reseptorlengde, ved å måle mengden prostata spesifikk antigen (PSA), som en markør for androgenreseptor aktivitet. De med middels lang reseptor viste seg å ha den største mengden PSA i blodet. Dette skulle kunne ha betydning ved PSA screening for prostata kreft. |
Description: | The papers of this thesis are not available in Munin: 1. Skjærpe PA, Lundberg Giwercman Y, Giwercman A and Svartberg J.: 'Androgen receptor gene polymorphism and sex hormones in elderly men: the Tromsø study', Asian Journal of Andrology (2009) 11:222-228. Available at http://dx.doi.org/10.1038/aja.2008.7 2. Skjærpe PA, Lundberg Giwercman Y, Giwercman A and Svartberg J.: 'Androgen receptor gene polymorphism and the metabolic syndrome in 60-80 years old Norwegian men', International Journal of Andrology (2010) 33:500–506. Available at http://dx.doi.org/10.1111/j.1365-2605.2008.00942.x 3. Nenonen H, Björk C, Skjærpe PA, Giwercman A, Rylander L, Svartberg J and Lundberg Giwercman Y.: 'CAG repeat number is not inversely associated with androgen receptor activity in vitro', Molecular Human Reproduction (2010) 16:153-157. Available at http://dx.doi.org/10.1093/molehr/gap097 4. Nenonen H, Skjærpe PA, Lippolis G, Sajid A, Bjartell A, Svartberg J, Giwercman A, Sävblom C and Lundberg Giwercman Y.: 'Androgen receptor CAG length dependent amount of prostate specific antigen in serum and in tissue' (manuscript) |
URI: | http://hdl.handle.net/10037/4564 |
URI: | http://hdl.handle.net/10037/6660 |
Abstract: | In this thesis different factors that promote or inhibit heart remodelling induced by angiotensin II were studied. The following conclusions can be drawn: 1. The presence of elevated levels of Ang II in the perfusion buffer did not increase myocardial injury during ischemia-reperfusion. However, the ability to protect the heart by ischemic postconditioning was lost. This seemed to be due to blockade of ERK1/2 signalling and GSK3-β inhibition induced by postconditioning. Elevated levels of Ang II, which is seen in untreated cardiovascular disease and in kidney disease, could therefore contribute to limit the outcome of the potential clinical use of postconditioning. 2. Non-compensatory (non-hypertrophic) heart remodelling was triggered by high-dose Ang II. This leads to changes in the contractile apparatus and reduced tolerance to ischemia in the absence of cellular hypertrophy. Increased expression of key genes involved in fibrosis was followed by an increase in interstitial fibrosis in heart tissue, which partly explains the post ischemic diastolic dysfunction. 3. Pregnancy did protect against the detrimental effects of Ang II since cardiac remodelling, fibrosis and reduced vessel density were less prominent in pregnant rats. 4. Iso treatment induced heart hypertrophy in both genders, but increased fibrosis was found only in males. Unlike the situation with exposure to high concentrations of Ang II, female gender did protect against the increase in fibrosis after Iso treatment. In summary, we can conclude that female gender and the unique female physiological status of pregnancy protect the heart, and provide a better handling of various stress stimuli after moderate Ang II and β-adrenergic influence. When the angiotensin II exposure reaches sub-toxic levels the protection afforded by female gender is lost. |
Description: | Papers number 1, 3 and 4 of this thesis are not available in Munin: 1. M. B. Aljabri , T. Lund, T. V. Andreasen and K. Ytrehus: 'Angiotensin II abates the beneficial effects of postconditioning in ERK and GSK- 3β dependent manner' (submitted paper) 3. M. B. Aljabri, N. T. Songstad, T. Lund, M. C. Serrano, T. V. Andreasen, S. Al-Saad, S. Lindal, V. Sitras, G. Acharya, K. Ytrehus: 'Pregnancy protects against antiangiogenic and fibrogenic effects of angiotensin II in rat hearts', Acta Physiologica (Oxf) (2011) Apr;201(4):445-56. Available at http://dx.doi.org/10.1111/j.1748-1716.2010.02234.x 4. M. B. Aljabri , T. Lund, S. Al-Saad, J. Benjaminsen, T. V. Andreasen and K. Ytrehus: 'Chronic isoproterenol treatment enhances extracellular fibrosis and postischemic diastolic dysfunction in male but not female rat heart' (manuscript) |
URI: | http://hdl.handle.net/10037/3555 |
Description: | The papers of the thesis are not available in Munin:
1. Knut Johnsen, Jan Tore Gran , Knut Dale and Gunnar Husby: «The prevalence of ankylosing spondylitis among Norwegian Samis (Lapps)», J Rheumatol 1992; 19(10):1591-1594. Check availability 2. Knut Johnsen, Markku Mähönen and Per Lunde: «Prevalence estimation and follow-up of aortic regurgitation subjects in a Norwegian Sámi population», Scandinavian Cardiovascular Journal, 2009; Vol. 43, No. 3, Pages 176-180 (Informa Healthcare). Available at http://dx.doi.org/10.1080/14017430802535055 3. Knut Johnsen, Rasmus Goll and Olav Reikerås: «Acetabular dysplasia in Sámi population: a population study among Sámi in north Norway», International Journal of Circumpolar Health 67:1 2008 (International Association of Circumpolar Health Publishers). Available at http://ijch.fi/issues/671/Johnsen.pdf 4. Knut Johnsen, Rasmus Goll and Olav Reikerås: «Acetabular dysplasia as an aetiological factor in development of hip osteoarthritis», International Orthopaedics, Volume 33, Number 3 (Springer). Available at http://dx.doi.org/10.1007/s00264-008-0554-7 |
URI: | http://hdl.handle.net/10037/2597 |
Abstract: | Cationic antimicrobial peptides (CAPs) are found in many diverse species playing a part in the innate immune system. CAPs are important as antimicrobial agents in most organisms, being able to kill a wide range of bacteria as well as fungi, enveloped viruses and protozoa. Certain CAPs also exhibit direct cytotoxic activity against many different types of human cancer cells. Bovine lactoferricin (LfcinB) derived from the protein bovine lactoferrin found in cow milk has been the starting point for this thesis. LfcinB is a CAP which exhibits antimicrobial and antitumor activities. In the present work the main focus has been to explore the anticancer activity of LfcinB and the de novo designed peptide, LTX-302, which is a 9-mer cytolytic peptide optimalized from parental LfcinB.
We found that LfcinB kill cancer cells by necrosis due to a dual mechanism of the peptide on both the mitochondrial membranes and the plasma membranes. In vivo studies of the more active peptide, LTX-302, demonstrated a vaccinating effect against the murine A20 B-cell lymphoma in immunocompetent mice. Subcutaneously established tumors were treated with LTX-302 by intratumoral injection of the peptide and a majority of the tumors obtained complete regression upon LTX-302 treatment. The cured mice were found to be protected against a rechallenge with A20 cells, but not against Meth A sarcoma cells, indicating a specific immune response. The complete regression was T-cell dependent, and both CD4 and CD8 T-cells were required for the protection. These studies show that local treatment of cancer by a CAP can induce active immunization against the cancer, conferring a novel strategy for therapeutic vaccination against cancer. |
Description: | The papers of the thesis are not available in Munin:
1. L.T. Eliassen, G. Berge, B. Sveinbjørnsson, L. Vorland, J.S. Svendsen, Ø. Rekdal: 'Evidence for direct antitumor mechanism of action by bovine lactoferricin', Anticancer Research (2002), 22:2703-2710 (International Institute of Anticancer Research - publisher's restriction). Check availablility 2. Liv Tone Eliassen, Gerd Berge, Arild Leknessund, Mari Wikman, Inger Lindin, Cecilie Løkke, Frida Ponthan, John Inge Johnsen, Baldur Sveinbjørnsson, Per Kogner, Trond Flægstad and Øystein Rekdal: 'The antimicrobial peptide, Lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo', International Journal of Cancer, Volume 119, Issue 3 (p 493-500) (Wiley - publisher's restriction). Available at http://dx.doi.org/10.1002/ijc.21886 3. Berge, G., Eliassen, L. T., Sveinbjørnsson, Bartnes, K. Ø. Rekdal: 'Therapeutic vaccination against a murine lymphoma by intratumoral injection of a cationic anticancer peptide' (Manuscript) |
URI: | http://hdl.handle.net/10037/2373 |
Abstract: | Ampicillin er et antibiotikum som har vært brukt i flere tiår, og det er mange bakterier på sykehus og andre helseinstitusjoner som har utviklet resistens mot dette legemiddelet. Bakteriene blir resistente ved selv å utvikle eller ta opp resistensgener. Vi vet lite om bakteriene utenfor sykehusmiljøene har resistensgener mot ampicillin. Kunnskap om resistensgener i miljø hvor det er lite menneskelig påvirkning kan si oss noe om hvorvidt antibiotikaresistens oppstår i disse miljøene og så spres til klinikken eller motsatt. Glad ville videre finne ut hvilke typer bakterier som finnes i tarmsystemet til arktiske dyr. Hun har også studert samspillet mellom bakterier i reinens vom og det naturlige antibiotikumet usninsyre som finnes i laven reinen spiser. For å undersøke forekomsten av ampicillinresistens ble det tatt avføringsprøver fra isbjørn på Svalbard og fra sel i Vestisen. I tillegg ble forekomsten av resistensgener i jord og sedimenter på Svalbard og i Troms undersøkt. Glad var mest interessert i et spesielt gen, blaTEM-genet, som gjør bakteriene i stand til å ødelegge ampicillin, og brukte molekylære teknikker for å lete etter dette genet. Studiene viste at det var svært lite av dette genet i disse miljøene. Isbjørnene hadde en lite variert bakterieflora. Den var hovedsakelig dominert av stavformede bakterier kalt klostridier som også dominerer blant menneskets tarmbakterier. Dette bekrefter tidligere resultater som viser at kjøttetende dyr har færre bakterier og et mindre mangfold av bakterier i fordøyelsessystemet. Kjøttetende dyr fordøyer proteiner og fett raskt sammenlignet med fiberfordøyelsen hos planteetende dyr. Dette forklarer den lave diversiteten av bakterier i isbjørnens tarm. Hos selene derimot var flesteparten av bakterien ukjente og har aldri tidligere vært beskrevet. Hun fant også bakterier i reinens vom som var resistente mot usninsyren som finnes i lav. Disse bakteriene kan være involvert i nedbryting av usninsyre sånn at reinen kan spise og fordøye lav som er giftig for de fleste andre dyr og mennesker. |
Description: | Papers number 1, 3 and 4 of the thesis are not available in Munin: 1. Brusetti, L., T. Glad, S. Borin, P. Myren, A. Rizzi, P. J. Johnsen, P. Carter, D. Daffonchio and K. M. Nielsen:'Low prevalence of blaTEM genes in Arctic environments and agricultural soil and rhizosphere', Microbial Ecology in Health and Disease (2008), 20: 27-36. (Publisher's restriction) Available at http://dx.doi.org/10.1080/08910600701838244 3. Glad T., V. F. Kristiansen, K. M. Nielsen, L. Brusetti, A.-D. Wright and M. A. Sundset:'Ecological characterisation of the colonic microbiota in Arctic and sub-Arctic seals', Microbial Ecology (2010), 60: 320-30. (Publisher's restrictions). Available at http://dx.doi.org/10.1007/s00248-010-9690-x 4. Glad, T., P. Barboza, A. Kohn, R. I. Mackie, A.-D. Wright, L. Brusetti, S. D. Mathiesen and M. A. Sundset:'Effect of usnic acid, a natural antibiotic in lichens, on rumen microbial ecology and resistance in reindeer' (manuscript) |
URI: | http://hdl.handle.net/10037/3369 |
Abstract: | In this doctoral project we have examined the biological effects of Calanus oil in a mouse model of obesity. Calanus oil is extracted from the marine copepod Calanus finmarchicus and is one of the richest sources of poly-unsaturated fatty acids in nature. C57BL/6J mice were given a high-fat diet (HFD) over a 27 wk period in order to induce obesity, which was reflected in deposition of considerable amounts of fat in the abdominal cavity and liver. In mice receiving HFD supplemented with a small amount of Calanus oil (1.5%) fat accumulation was significantly less, despite no difference in food intake between the groups. Obesity was also associated with increased expression of genes (mRNA level) coding for pro-inflammatory molecules, as well as macrophage infiltration in adipose tissue, indicative of a local (low-grade) inflammation. Moreover, insulin sensitivity was impaired as documented by reduction in glucose tolerance. These obesity-induced alterations were clearly antagonized by dietary Calanus oil, irrespective of whether it was given from the onset of the feeding period or after obesity was established. Another important finding was that wax ester from Calanus oil (i.e. the pure lipid component of the oil, devoid of antioxidants and other bioactive substances) was as effective as crude Calanus oil for obtaining these beneficial effects, and the efficacy of wax ester in producing the anti-obesity effect was even stronger than that of the clinically used ethyl esters of purified EPA and DHA. Finally, the increase in blood pressure which occurred when obese C57BL/6J mice were challenged by angiotensin II infusion was virtually abolished in mice that had been pre-treated with dietary Calanus oil. Dietary Calanus oil also antagonized the reduction in body and organ weights associated with angiotensin II infusion. |
Description: | The papers of this thesis are not available in Munin: I. Höper, Anje Christina; Salma, Wahida; Khalid, Ahmed Murtaz; Hafstad, Anne Dragøy; Sollie, Selene Julie; Raa, Jan; Larsen, Terje; Aasum, Ellen. Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013; Volum 110. s. 1145 2186 - 2193. Available at http://dx.doi.org/10.1017/S0007114513001839 II. Höper, Anje Christina; Salma, Wahida; Sollie, Selene Julie; Hafstad, Anne Dragøy; Lund, Jim; Khalid, Ahmed Murtaz; Raa, Jan; Aasum, Ellen; Larsen, Terje. Wax esters from the marine copepod calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. Journal of Nutrition 2014; Volum 144 (2), s.164 – 169. Available at http://dx.doi.org/10.3945/jn.113.182501 III. Salma W, Franekova V, Lund T, Höper AC, Ludvigsen S, Lund J, Aasum E, Ytrehus K, Belke DD, Larsen TS. Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in obese mice. Manuscript submitted in American journal of Physiology. (Manuscript). |
URI: | http://hdl.handle.net/10037/7040 |
Description: | Papers 1,2 and 3 of this thesis are not available in Munin: 1. Augestad KM, Lindsetmo RO, Stulberg JJ, Reynolds H, Senagore AJ, Champagne B, Heriot AG, Leblanc F and Delaney CP.: 'International preoperative rectal cancer management: staging, neoadjuvant treatment, and impact of multidisciplinary teams', World Journal of Surgery (2010), vol. 34:2689-2700. Available at http://dx.doi.org/10.1007/s00268-010-0738-3 2. Augestad KM, Lindsetmo RO, Stulberg JJ, Reynolds H, Senagore AJ, Champagne B, Heriot AG, Leblanc F and Delaney CP.: 'International trends in surgical treatment of rectal cancer', American Journal of Surgery (2011), vol. 201:353–358. Available at http://dx.doi.org/10.1016/j.amjsurg.2010.08.030 3. Augestad KM, Lindsetmo RO, Stulberg J, Reynolds H, Champagne B, Senagore AJ and Delaney CP.: 'System-based factors influencing intraoperative decision-making in rectal cancer by surgeons. An international assessment', Colorectal Disease (2012), vol. 14(10):e679-88. Available at http://dx.doi.org/10.1111/j.1463-1318.2012.03093.x |
URI: | http://hdl.handle.net/10037/5167 |
Abstract: | Summary: According to the WHO, breast cancer is by far the most frequently diagnosed cancer, and the most frequent cause of cancer death among women in the world. Tobacco smoking is the single largest cause of cancer worldwide and has been linked to cancer in most organ systems. The aim of this thesis was to illuminate the association between smoking and breast cancer incidence, mortality, and to study the socioeconomic consequences of smoking-associated breast cancer in a large Norwegian cohort with a high number of female smokers. In Paper I we investigated the association between active smoking and breast cancer incidence. We found an increased risk of 15% for ever smokers overall, as well as an increased breast cancer risk with increasing number of cigarettes smoked per day, smoking duration, number of pack-years smoked, and lower age at smoking initiation. We found an increasing risk with longer smoking duration before first childbirth, and no increased risk among those who started to smoke after first childbirth. In Paper II we investigated the association between smoking and breast cancer mortality, which revealed a 15% increased risk of breast cancer mortality for ever smokers. Most of the results for the different smoking exposures considered were not statistically significant. In Paper III, we used level of education as a validated measure of socioeconomic status, and investigated whether level of education had an impact on the risk of smoking-associated breast cancer. We did not find an increased risk of smoking-associated breast cancer in women with high level of education, but we were able to confirm that smoking before first childbirth remains a risk factor for breast cancer, regardless of educational achievement. Smoking-associated breast cancer does not seem to have an important impact on social inequalities in health. Active smoking, in particular active smoking before first childbirth, emerges as a risk factor for breast cancer incidence. |
Description: | Paper 3 of the thesis is not available in Munin: 3. Bjerkaas E, Parajuli R, Engeland A, Maskarinec G, Weiderpass E, Gram IT: 'Social inequalities and smoking-associated breast cancer – results from a prospective cohort study', submitted manuscript. |
URI: | http://hdl.handle.net/10037/6799 |
Description: | Papers in this thesis:
I: Gram, Inger Torhild, Lund-Larsen, Per G., Rosenlund, Alf Frimann, Størmer, Jan: 'Mammografiscreening i Tromsø'. Særtrykk av Tidsskrift for Den norske Lægeforening nr. 10, 1989;109, s. 1040-1042. II: I T Gram and S E Slenker : 'Cancer anxiety and attitudes toward mammography among screening attenders, nonattenders, and women never invited',. American Journal of Public Health: February 1992, Vol. 82, No. 2: 249–251 (http://dx.doi.org/10.2105/AJPH.82.2.249) III: IT Gram, E Lund and SE Slenker: 'Quality of life following a false positive mammogram'. British Journal of Cancer, 1990 62, 1018-1022 (http://dx.doi.org/10.1038/bjc.1990.430) IV: Inger T. Gram, Harland Austin, and Helge Stalsberg: Cigarette Smoking and the Incidence of Cervical Intraepithelial Neoplasia, Grade III, and Cancer of the Cervix Uteri, Am. J. Epidemiol. (1992) 135 (4): 341-346. V: Inger T. Gram, Maurizio Macaluso, Helge Stalsberg: ' Oral contraceptive use and the incident of cervical intraepithelial neoplasia'. (Manuscript) Published version: American Journal of Obstetrics and Gynecology, Volume 167, Issue 1, July 1992, Pages 40–44 (http://dx.doi.org/10.1016/S0002-9378(11)91622-6) VI: Inger Torhild Gram, Maurizio Macaluso, Jeanetta Churchill, Helge Stalsberg: 'Trichomonas vaginalis (TV) and human papillomavirus (HPV) infection and the incidence of cervical intraepithelial neoplasia (CIN) grade III', 1992, Volume 3, Issue 3, pp 231-236 (http://dx.doi.org/10.1007/BF00124256) |
URI: | http://hdl.handle.net/10037/7033 |
Abstract: | Methods and aims We performed open, randomized, placebo-controlled experimental studies in intact, anesthetized pigs with the following main aims: Paper 1 To describe in detail the hemodynamic function with emphasis on left ventricular contractility during surface cooling, steady state severe hypothermia at 25°C, surface rewarming and in the post-hypothermic period of 2 h. Paper 2 1) To investigate the pharmacokinetic properties of DA in normothermia and hypothermia. 2) To carry out a detailed analysis of the cardiovascular response to incrementing dosages of dopamine (DA) at core body temperatures at normothermia, at steady state hypothermia at 25°C, and during rewarming in the temperature span of 30 - 34°C. Paper 3 To compare differences between immersion cooling and cooling by cardiopulmonary bypass (CPB) in cardiovascular function and global delivery and consumption of oxygen i) during cooling until deep hypothermic circulatory arrest; ii) during rewarming by CPB; and iii) during the 2 h post-hypothermic period following weaning from CPB. Main results and conclusions Surface cooling, followed by surface rewarming, resulted in a mild post-hypothermic systolic cardiac failure that was well compensated for. Diastolic function was unaffected (Paper 1). Pharmacokinetics of DA was seriously altered at 25°C and DA did not increase cardiac output, but had the adverse effects of increased systemic vascular resistance (Paper 2). Immersion cooling to hypothermic circulatory arrest, followed by rewarming taking place on CPB, resulted in severe and uncompensated cardiovascular failure not encountered in CPB-cooled animals (Paper 3). |
Description: | Paper 2 and 3 of this thesis are not available in Munin: 2. Filseth OM, How O-J, Kondratiev T, Gamst TM, Sager G, Tveita T.: 'Changes in cardiovascular effects of dopamine in response to graded hypothermia in vivo', Critical Care Medicine (2012), 40(1):178-86. Available at http://dx.doi.org/10.1097/CCM.0b013e31822d78de 3. Filseth OM, Hermansen SE, Kondratiev T, Tveita T.: 'Cooling to hypothermic circulatory arrest by immersion vs. cardiopulmonary bypass : worse outcome after rewarming in immersion cooled pigs' (manuscript) |
URI: | http://hdl.handle.net/10037/4366 |
Abstract: | Helsepolitikk for samer har bygd på antakelser om at språk- og kulturforskjeller mellom helsepersonell og pasienter fører til et underforbruk av helsetjenester og en dårligere helsetjeneste. Første studie i denne avhandlingen analyserer forbruket av sykehus, og avviser at det er et underforbruk av helsetjenester blant samer generelt, men finner at de eldste innbyggerne i samiske kommuner er noe sjeldnere på sykehus enn eldre ellers i landet. Siden 1963 har man forsøkt å forbedre helsetjenesten i samiske kommuner gjennom samisk kvote på helsefagutdanninger. Samisk kvote på medisin skulle resultere i flere samiske leger i samiske kommuner. En sporingsstudie i denne avhandlingen stiller spørsmål ved kvoter som egnet virkemiddel til dette i dag. En sammenlignende studie fra USA, Canada, Australia og New Zealand peker på at effekter av slike kvoteordninger sjelden undersøkes. |
Description: | Paper 3 of this thesis is not available in Munin: 3. Margrete Gaski: 'A comparative study of strategies for recruiting young Indigenous People to become physicians : nearly fifty years of preferential admission and support (accepted manuscript in Human Resources for Health) |
URI: | http://hdl.handle.net/10037/4142 |
Abstract: | Avhandlingens tittel er "Aspects of the primary assessment and management of anal incontinence - The introduction of a new treatment". Disputas for graden Ph.D. finner sted 05.04.2013. Ufrivillig lekkasje av luft og avføring er en relativt vanlig og belastende tilstand, og kan gi redusert livskvalitet. Det er utviklet en ny metode for å behandle denne lidelsen, som består i å injisere et rom-oppfyllende stoff i endetarmskanalen. Det sentrale målet i prosjektet har vært å vurdere om denne nye behandlingen er bedre enn eksisterende metoder. I tillegg har prosjektgruppen ønsket å utvikle metoder til å vurdere anal inkontinens bedre. |
Description: | The papers of this thesis are not available in Munin: 1. Norderval S, Dehli T, Vonen B.: 'Three-dimensional endoanal ultrasonography: intraobserver and interobserver agreement using scoring systems for classification of anal sphincter defects', Ultrasound in Obstetrics and Gynecology (2009), vol. 33 (3): 337-43. Available at http://dx.doi.org/10.1002/uog.6295 2. Dehli T, Martinussen M, Mevik K, Stordahl A, Sahlin Y, Lindsetmo RO, Vonen B.: 'Translation and validation of the Norwegian version of the fecal incontinence quality-of-life scale', Scandinavian Journal of Surgery (2011), vol. 100 (3): 190-5. Available at http://www.fimnet.fi/sjs/articles/SJS32011-190.pdf 3. Dehli T, Stordahl A, Vatten LJ, Romundstad PR, Sahlin Y, Lindsetmo RO, Vonen B.: 'Sphincter training or anal injections of dextranomer for treatment of anal incontinence: a randomized trial', Scandinavian Journal of Gastroenterology (2013) Vol. 48, No. 3. Available at http://dx.doi.org/10.3109/00365521.2012.758770 |
URI: | http://hdl.handle.net/10037/5047 |
Abstract: | During the last decade, child psychiatry has been a focus of the Norwegian government's plan to improve mental health care. Psychiatric assessment of children and adolescents is more complex than that of adults, and rating scales and diagnostic instruments have become increasingly important tools in both research and clinical practice. This dissertation investigates standardized assessment instruments used in routine clinical practice to assign diagnoses and severity of mental health problems. Both the reliability and the validity of some instruments were examined, and a main focus was the clinical usefulness of these instruments and their potential for more effective use of limited clinical resources. In paper 1 the agreement between diagnoses and severity ratings assigned by clinical specialists who were trained Child and Adolescent Mental Health Service (CAMHS) researchers examined. Information on 100 youths was obtained from multiple informants through a webbased Development and Well-Being Assessment (DAWBA). Based on this information, four experienced clinicians independently diagnosed (according to the International Classification of Diseases Revision 10) and rated the severity of mental health problems according to the Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) and the Children's Global Assessment Scale (C-GAS). Agreement for diagnosis was - =0.69-0.82. Intra-class correlation for single measures was 0.78 for HoNOSCA and 0.74 for C-GAS, and 0.93 and 0.92, respectively for average measures. Information obtained with the online DAWBA may be a sound basis on which to establish reliable clinical diagnoses and severity ratings for common mental health disorders in a clinical setting. A clinical practice that includes systematic, multiple independent assignments of diagnosis and severity, is preferable due to the resulting improved reliability of the severity ratings. In paper 2 the application of specific scoring algorithms for the Strengths and Difficulties Questionnaire (SDQ) was examined. Could available online norms be useful in screening for mental health disorders among children and adolescents in the CAMHS North Study? A total of 286 outpatients, aged 5 to 18 years, were assigned diagnoses based on the DAWBA. The main diagnostic groups (emotional, hyperactivity, conduct and other disorders) were then compared to the SDQ scoring algorithms using two dichotomisation levels: 'possible' and 'probable' levels. Sensitivity for the diagnostic categories included was 0.47-0.85 ('probable' dichotomisation level) and 0.81-1.00 ('possible' dichotomisation level). Specificity was 0.52-0.87 ('probable' level) and 0.24-0.58 ('possible' level). The discriminative ability, as measured by ORD, was in the interval for potentially useful tests for hyperactivity disorders and conduct disorders when dichotomised on the 'possible' level, but outside the interval for potentially useful tests for all diagnostic categories when dichotomised on the most common used 'probable' level. In conclusion, the ability of the SDQ to detect mental health disorders among patients referred to CAMHS is not sufficient for clinical purposes. When used as a screening instrument to determine whether further evaluation is warranted in a clinical CAMHS sample, the SDQ seems best suited to identify children and adolescents who do not require further psychiatric evaluation, although this also is problematic from a clinical point of view. In paper 3 the agreement between diagnoses and severity assigned by clinical specialists trained as CAMHS researchers, based only on DAWBA information collected online, and the routine clinical assignments by CAMHS clinicians was examined. Routine clinical assignment of diagnoses was compared to online clinical assignment of diagnoses for 286 patients from the CAMHS North study. Chi square analysis, kappa statistics and multinomial logistic regression analyses were performed. Raw agreement for diagnostic categories varied between 74% and 90%, resulting in kappa values of 0.41-0.49. The final multinomial regression models were significant. Agreement on mental health diagnoses can be fair when online clinical assignments and routine clinical assignments of mental health diagnoses are compared. This may be sufficient to replace the routine clinical assignment of diagnoses with an online clinical assignment in order to save time and resources. We also examined factors contributing to agreement or disagreement on the diagnoses. Age, gender and number of informants significantly contributed to the explanation of agreement and disagreement for 'emotional diagnosis' and 'hyperkinetic/conduct diagnosis'. However, the changes in odds were small in magnitude and the factors probably do not consistently contribute to the understanding of agreement or disagreement in any clinically meaningful way. Lastly, implications for further research on reliable and effective assessment methods are discussed. |
Description: | Paper 3 of this thesis is not available in Munin: 3. Brondbo PH, Mathiassen B, Martinussen M, Handegard BH and Kvernmo S.: 'Agreement on diagnoses and severity of mental health problems between a research and a naturalistic clinical setting' (manuscript). |
URI: | http://hdl.handle.net/10037/4521 |
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lois patiño
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Lois Patiño was born in Vigo (Spain) in 1983. He combined his Psychology studies in the Complutense University of Madrid with cinema studies at TAI School. He followed his cinema education at NYFA, in New York and with the Master in Cinema Documentary at Pompeu Fabra University in Barcelona. He has developed courses of videocreation under the guidance of Katherin Sieverding in the UdK of Berlin, and in different ateliers with artist and filmmakers such as Joan Jonas, Donald Kuspit, Pedro Costa, Víctor Erice, José Luis Guerín or Daniel Canogar. He has worked in collaboration with the director Mercedes Álvarez in her second feature film "Futures Market".
His works have been shown in art centres screens such as Casa Encendida (Madrid), Fundación CaixaGalicia (A Coruña), MARCO (Vigo), Fundación Luis Seoane (A Coruña)... and in international festivals as Locarno, New York Film Festival, BAFICI, Oberhausen, Roma, Vila do Conde, Media City, Jihlava, Punto de Vista, Las Palmas, Documenta Madrid... or in Rencontres Internationales París/ Berlín/ Madrid, which took place in Centre Georges Pompidou (París), Reina Sofía Museum (Madrid) and Haus der Kulturen der Welt (Berlin). With his work "Mountain in Shadow" won a Prize at the Oberhausen film festival, and in the 66th edition of the Locarno Film Festival he recieve the prize for the best emerging director with his work "Costa da Morte".
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September 10, 2014
Today, PayScale released its annual rankings of alumni salaries and return on investment for American colleges and universities — and, according to the company's nationwide employer survey, Wagner [...] Keep reading →
September 8, 2014
Princeton, Harvard … Williams, Amherst … It may seem like there are no surprises in the new U.S. News & World Report's overall rankings of top colleges and universities, released this morning. [...] Keep reading →
September 4, 2014
Wagner College ranked very high on the list of colleges chosen by students who were admitted to more than one school, according to the recently released Parchment Student Choice College Rankings 2015. [...] Keep reading →
August 21, 2014
Thursday, Aug. 21 was move-in day! Orientation coordinators Christian Grotewold and Darnell Kenney give us a behind-the-scenes look at the first day of orientation. Also with Dillon Quinn, Jennifer Beliard, [...] Keep reading →
August 19, 2014
Early this Thursday morning, Aug. 21, Wagner College welcomes the 451 members of its new freshman class for move-in to the recently refurbished Harbor View Hall high-rise residence facility and the beginning [...] Keep reading →
August 5, 2014
Wagner College was featured, once again, in the Princeton Review's "Best 379 Colleges" guide, which was released on Tuesday, Aug. 5. Special kudos went to the college's theater program and campus [...] Keep reading →
July 30, 2014
For the second year in a row, Wagner College appears on the Forbes 2014 Top Colleges list, produced in partnership with the Washington, D.C.-based Center for College Affordability and Productivity. This [...] Keep reading →
July 28, 2014
On July 28, Money magazine released its first-ever national ranking of best-value colleges -- and Wagner College ranked in the top third among all colleges and universities across the country, big and [...] Keep reading →
July 25, 2014
Wagner College hosts an MBA Program Open House on Wednesday, July 30 from 6 to 8 p.m. in the Spiro Sports Center. (See the campus map below for location.) This is an informal event where prospective [...] Keep reading →
July 8, 2014
Beginning this August, Wagner College's Evelyn L. Spiro School of Nursing will enroll the first cohort in its new Doctor of Nursing Practice program. An open house for those interested in the program [...] Keep reading →


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Required Reading: Essential Documentaries and Funny Superheroes
Features By Scott Beggs on September 4, 2014 | Be the First To CommentThe best movie culture writing from around the internet-o-sphere. There will be a quiz later. Just leave a tab open for us, will ya?
Fund This 'Notfilm': About the 1965 Film 'Film' Written by Samuel Beckett and Starring Buster Keaton
Features By Christopher Campbell on November 23, 2013 | Be the First To CommentBuster Keaton appeared in some very weird movies following the advent of sound pictures. There's that Mexican sci-fi comedy Boom in the Moon I mentioned on FSR a while back. There's the Eastman Kodak industrial film The Triumph of Lester Snapwell, in which he plays a clumsy photographer who travels through time so he can experience an easy-use Instamatic camera. And of course all those crazy '60s beach movies, where he performed silly slapstick involving bikinis, boobs and a politically incorrect portrayal of a Native American. But his oddest has to be Film, the 1965 short he reluctantly starred in, which was scripted by absurdist playwright Samuel Beckett (his only original written directly for the screen), helmed by theatre director Alan Schneider, produced by controversial publisher Barney Rosset, edited by Oscar-nominated documentarian Sidney Meyers (The Quiet One; The Savage Eye) and shot by legendary cinematographer Boris Kaufman (L'Atalante; On the Waterfront). Almost 50 years since its debut at the Venice Film Festival, Film is being restored by Milestone Films, the wonderful people who in recent years have resurfaced Killer of Sheep, Portrait of Jason, Word is Out and other classics in need. And its 2014 re-release will be in conjunction with a documentary feature/essay film (or "kino essay") titled Notfilm, directed by archivist Ross Lipman. Tons of bonus footage, including deleted, alternate and "lost" scenes, has been found from the production, and we'll get to see all that alongside interviews with Leonard Maltin, Kevin Brownlow and Haskell Wexler, among others (plus […]
Win a $500 Gift Card Just For Asking Us a Question For Comic-Con
Features By Scott Beggs on July 18, 2011 | Be the First To CommentComic-Con is around the corner, and while our dance card is filling up, we've carved out some time to hang out with veteran film critic, author, and film historian Leonard Maltin. Unlike two years ago when we ended up hanging out by the San Diego docks with Tom Jane and the Raw crew at 3am, we'll be keeping it a little tamer this year at the Movies On Demand lounge inside the Hard Rock Hotel on Saturday, July 23rd from 3-5pm. So what does our drinking in the afternoon have to do with you winning $500? Great question. Speaking of questions, we need them for our conversation, and we want to give you the chance to win that half-thousand-dollar gift card just for sending us yours. Here's how to enter:
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Connect with MAcc and MBT Ambassadors to learn more about USC Leventhal.Arvind RamachandranPrevious Industry/Function: Consulting / Strategy
Intended Industry/Function: Digital Media / MarketingWhy did you choose Marshall?
Choosing a business school means finding the best fit for you. Marshall was the only school that emphasized personal development on top of the standard career development program that other schools offer. This and the Centers of Excellence for academic research played a big part in my decision as I wanted to work with thought leaders.
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Grad schools are often walled from other programs in a university. From the first day I set foot in USC, I knew that I was a Trojan for life. The collaboration and affection between the different programs and schools at USC meant that I wasn't just restricted to my friends in the MBA program. My network now includes people as diverse as a professional football player, a film-major, a linguist and a policy maker.
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Labor's defeat by Boeing portends bad news for working class, decline for U.S.
Late last week while having my morning coffee I listened to an interesting news item aired on NPR. It briefly reported that the Boeing Company and its machinists agreed that if Boeing manufactured its latest model aircraft in the Seattle area, the machinists would give the company significant wage and benefit concessions.
One of the issues was whether or not the workers would switch their retirement program from a traditional "fixed benefit plan to a "fixed contribution plan" aka 401K plans, where the retirement benefit is not fixed, but variable and a function of how well the financial markets perform.
This will limit future retirement liability for the company and save it a bunch of money over the long haul.
For future retirees, however, it isn't so good. Depending on the vagaries of the financial markets, they could do well or they could end their days as poor as "church mice" even though they will have done nothing wrong.
Looking back over the years, we have seen a boom-bust cycle on Wall Street that has been horrible for investors while being great for Wall Street professionals.
To put it bluntly, investing is risky business, best left to professionals. PBS' Frontline did a great program on the riskiness associated with investing retirement programs in the stock market.
The deal was made, however, modifying the existing machinists' labor contract at a time that the union could not strike if the deal was rejected. Hardly a level playing field. The machinist union recommended a thumbs down vote, but deal passed nonetheless by a narrow margin.
On the face of it, the deal appears to be a good one. The jobs stay in Seattle and the workers get less wages/benefits. The wave of the future. The company significantly reduces its labor costs, which improves its bottom line. An improved bottom line equals higher salaries for management, especially top level, and a higher stock value for the stock holders.
I don't think it is so hot for the workers, however. The short term is rosy, that is if Boeing doesn't renege down the road, but the long term isn't so good.
The employee retirement plan is much less secure. Investing retirement plans in the stock market where it is subject to unscrupulous management and the ups and downs inherent in the market has proven to be very risky and is controvercial.
This corporate practice of threatening job loss if concessions are not forth coming has been going on for decades now. It guarantees corporate cost savings at the expense of American workers. It also contributes to the rampant income disparity that plagues America today and it has had a devastating effect on the working class.
It is no secret that the rich have gotten richer as the poor have gotten poorer as a result of this highly unethical practice. Look at Detroit. Once the symbol of American prosperity, it is now bankrupt.
Clearly our "free market" economy is failing. Measures must be taken to curb the corporate ability to shop jobs all around the world at a whim. Just as corporations are treated as persons politically, they must be required to pledge their alliegance to the United States, just as ordinary citizens are.
As far as I am concerned, when a company sends their manufacturing overseas, its management should be required to surrender their passports at the border and find a new home country.
What is the end game here? Wall Street has run amok, jobs have gone overseas and a growing number of American workers cannot find a job that pays a living wage. The inevitable result is that when the working class cannot spend on consumer goods, the economy is going to collapse and our country will continue its relentless decline.
I am now nearly 71 years old and I have watched as our nation has squandered its wealth. When I was 20 years old, anyone could vacation in Europe on $50 a day. Now $50 won't buy dinner at a good restaurant in Europe, or here, for that matter.
So every time I learn that an iconic corporation like Boeing or IBM has reduced its employee pay package, I see it as another nail in the coffin that will be America if we continue along the path we are on.
Somehow the people of this country must find a way to convince the powerful elites who run things to change direction and reverse this downward economic spiral or we will find ourselves a third world country.
Unfortunately we cannot look to government for relief. Wall Street, corporate America and wealthy individuals rule.
It is obvious that elected officials are only interested in campaign contributions. The more you contribute, the more influence you can buy.
David Browning
Peachtree City, Ga.
I listen to NPR and have for many years. In the old day (70's) they were a little less biased. They even had a weekly program where Edward Kennedy and Bob Dole debated a topic. In their current iteration a balanced format is not likely.


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No redemption for India; memorable debut by Bairstow
An agonising tour wound to a close without any redemption for the Indian team. England reigned supreme in the fifth and final match of the NatWest Series at the Sophia Gardens here on Friday night. The host won by six wickets and the triumph helped England blank India 3-0 in the series.
Losses may have plagued the Indian team right through the four Tests, solitary Twenty20 game and two ODIs while a tie at Lord's offered little consolation but India hinted at a last-match hurray after scoring 304 for six in 50 overs. Virat Kohli (107) and Rahul Dravid (69) combined well, M.S. Dhoni (50 n.o.) flourished in the slog and later the rain forced two revisions in the target.
England was staring at an asking rate that kept mounting from the starting 6.1 to 6.27 and finally to 7.08 as two rain-interruptions meant that the target was adjusted to 295 from 47 overs and the eventual 241 from 34 overs as per the Duckworth-Lewis Method. The home team found the men to make rapid runs amidst mounting tension and the brightest spark was Jonathan Bairstow.
The debutant presented a dashing picture on the big stage and his rousing unbeaten 41 (21b, 1x4, 3x6) helped England finish with 241 for four in 32.2 overs.
Interestingly Bairstow received his England cap from Geoffrey Boycott ahead of the game and unlike the legend from his county Yorkshire, known for obduracy and solidity, the first-timer in international cricket played with flair to surprise and shock India.
England lost Craig Kieswetter early as he flicked fours off his toes and then missed one that Vinay Kumar angled in to rap the pad. Immediately skipper Alastair Cook (50, 54b, 5x4) and Jonathan Trott (63, 60b, 3x4) continued the chase without fuss. Trott lofted Munaf Patel straight past the sightscreen. The seamer then watched Parthiv Patel pouch Trott off a no-ball and exult rather than throw for a run-out and much later Munaf slipped in the outfield and the resultant injury completed India's agony.
Cook and Trott raised 79 runs for the second wicket before Kohli broke the partnership. Cook, dropped by Dravid, took a mighty heave against Kohli's next delivery and lost his timber. England stayed alive through Trott and Ian Bell. The duo bludgeoned meaty blows especially in a Ravindra Jadeja over that cost 21 runs. India briefly winged back into the game when R.P. Singh and Jadeja triggered fatal shots from Bell and Trott.
At 166 for four, England needed a cameo and Bairstow produced an innings that was lit up by clean hits down the ground. Jadeja was hoisted and reverse-swept, Vinay was clattered and taking a clue, Bairstow's senior partner Ravi Bopara, also switched gears. Bopara flicked a six and four over fine-leg while R.P. Singh struggled.
Dhoni juggled around Vinay, R.P. Singh and Kohli during the critical batting Power Play (overs 29 to 31) and watched Bairstow and Bopara plunder 42 runs. The match was sealed then and gradually the creased foreheads in the England dressing room eased while Indian shoulders slumped.
Dravid honoured
Soon it was time to shake hands and while England exulted, Dravid, playing his last ODI, was given the honour to lead the Indian team back to the dressing room.
A glorious limited-over career had wound to a close and amidst the sorrow of defeat and a farewell, Dhoni's 'Man-of-the-Series' award was the lone bright spot for India.
Considering that the 'Men in Blue' also lost their last two ODIs in the West Indies, India has found its aura of being the World Cup champion being diminished while key players recover from a wide range of injuries.
Injuries continued to haunt the Indian team even on the last day of its England tour.
Munaf injured
Munaf Patel, who fell while fielding in the deep during the ODI match at the Sophia Gardens on Friday, suffered an ankle injury and is likely to be out of action for a few weeks.
India: 304 for six in 50 overs.
England: A. Cook b Kohli 50 (54b, 5x4), C. Kieswetter lbw b Vinay 21 (17b, 4x4), J. Trott c R.P. Singh b Jadeja 63 (60b, 3x4, 2x6), I. Bell c (sub) Tiwary b R.P. Singh 26 (21b, 2x6), R. Bopara (not out) 37 (22b, 3x4, 1x6), J. Bairstow (not out) 41 (21b, 1x4, 3x6); Extras (lb-1, w-1, nb-1): 3; Total (for four wkts. in 32.2 overs): 241.
Power Plays: One (Overs 1-8): 44/1; Bowling (9-11): 21/0; Batting (29-31): 42/0.
Fall of wickets: 1-27 (Kieswetter), 2-106 (Cook), 3-160 (Bell), 4-166 (Trott).
India bowling: Vinay Kumar 6.2-0-42-1, R.P. Singh 7-0-51-1, Munaf 4-0-26-0, Ashwin 4-0-25-0, Jadeja 5-0-52-1, Kohli 6-0-44-1.
Keywords: NatWest Series


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Judas Priest, one of the forefathers of heavy metal, undoubtedly reached their peak on this album. Recorded in 1977 and released the next year, when only Deep Purple, Black Sabbath, and a select few other bands had even set foot in the realm of metal, it made a mark on popular music like only landmarks such as Sabbath's debut had before. Priest's previous efforts had just as much power and ability, but Stained Class took their skills to a new level. While their first three albums had shown great blues-rock influence, Stained Class stripped down the blues and took a step into more all-out metal territory. Rob Halford arguably gives his best performance until 1984's Defenders of the Faith. K.K. Downing and Glenn Tipton, as always, create a twin guitar sound that nobody short of Dave Mustaine and Marty Friedman could surpass, and Les Binks' drumming is superb. The result is a near-perfect production, not too raw or too sterile, that perfectly complements the tone of the songs.
And the songs may be some of the best Judas Priest has ever written. Even the weakest song on the album shows potential. The lyrics are insightful and interesting; the delivery, powerful. A sample from the opener, "Exciter:"
"Racing 'cross the heavens, straight into the dawn
Looking like a comet, slicing through the morn
Scorching the horizon, blazing through the land
Now he's here amongst us, the age of fire's at hand!"
You'd have to be deaf not to love that. Halford does a great job of enhancing the epic lyrics with his outstanding vocal prowess. His style prompts comparisons to that of Ronnie James Dio or Bruce Dickinson, to an extent, but at the same time displays a power all his own. Halford can hit unbelievable highs and inhuman screams, but never loses an ounce of strength. Even without the instrumentation, Halford enthralls. He can be catchy when he wants to; at the end of "Savage," for example, he sings almost in a chant,
"Who's the savage?--modern man!"
After you hear that for the first time, you'll never forget it.
The guitars form another high point. Downing and Tipton are obviously very skilled. They play no shortage of amazing and memorable riffs, not to mention the solos. Oh, the solos... some of the best I've heard this side of Fade to Black. They go from strong and defiant ("Exciter") to mournful ("Beyond the Realms of Death"). They will keep you spellbound; they will grip you and not let go for years to come. Simply astounding.
Now for an in-depth description of the actual songs:
"Exciter" showcases Judas Priest's pure heavy metal side, abound with solos, great riffs, and cool lyrics. It's the first of a series of "alien savior" epics (see "Painkiller") and works perfectly as an opener. On the other side of the spectrum, "Beyond the Realms of Death" displays Priest's ability to write an epic masterpiece. It starts out slow and brooding, before exploding into a loud, defiant chorus. The song proves that slow solos can be just as awesome and memorable as fast ones.
"Savage" describes the American Indians' encounters with European explorers, much like Iron Maiden later would with "Run to the Hills," leading one to believe that Harris took some influence from Priest. It's fun and often sound like it was actually written by the Native Americans. It's great to sing along to, as well. "Invader," which is along the same lines lyrically, except the invaders are aliens, is also an amazing song. The music seems to go along better with the Indian theme, though.
"Better By You, Better Than Me" and "White Heat, Red Hot" are pretty funky, and well done at that. There's a little bit of groovy rhythm in "Saints in Hell" and "Stained Class," as well. Judas Priest does quite a good job of merging these styles of music while still fully retaining their heavy metal sound. "Better By You..." sparked a fairly well-known lawsuit involving a teen suicide. While of course the case was absolute bogus, it did give the song some much-deserved exposure. As usual, Priest have outdone themselves in adding a metallic edge to a cover song.
"Heroes' End" is the weakest song here, but despite that, it's still interesting to listen to. It's nothing special, though, making it the only reason I didn't give Stained Class a perfect score. It doesn't really matter, though - before it there's a 38-minute streak of sheer brilliance.
All in all, Stained Class is a near-perfect record, where Priest successfully fuse many genres while remaining heavy metal through and through. Priest would later experiment with glam and other popular (at the time) genres, but they ultimately would never surpass their work on this album. If you don't have it already, send your ears to paradise and check it out. I promise you will absolutely not be disappointed.


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Copies of the financial schedules accompanying this press release are available at www.investor.jnj.com/historical-sales.cfm. These schedules include supplementary sales data, a condensed consolidated statement of earnings, and sales of key products/franchises. Additional information on Johnson & Johnson, including a pharmaceutical pipeline of selected compounds in late stage development and medical devices and diagnostics pipeline of selected products, can be found on the Company's investor website at www.jnj.com
(This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Johnson & Johnson. Risks and uncertainties include, but are not limited to, general industry conditions and competition; economic factors, such as interest rate and currency exchange rate fluctuations; technological advances and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approvals; domestic and foreign health care reforms and governmental laws and regulations; trends toward health care c
SOURCE Johnson & Johnson Copyright©2010 PR Newswire. All rights reserved |


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Uvalde County Ranch Information
Texas Ranches For Sale currently is working several nice ranches in Uvalde County that will be coming on the market soon. Please check our listings in nearby or adjoining counties. We also know about other ranches that are on the market, both listed and quietly on the market. If you have an interest in obtaining more information about these, please contact us to discuss your parameters - 830-249-9339. Keep in mind that we also research and locate on and off market ranches for Buyers.
County Seat: Uvalde
Area: 1,588 sq. miles
Location: Between San Antonio and the International Amistad Reservoir
Elevations: 700 to 2,000 feet.
Rainfall Average: 23.22 inches
Temperature: January low 37 degrees; July high 98 degrees
Rivers and Creeks: Nueces, Leona, Sabinal, Dry Frio Rivers


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Ice-Skating in the City
Four urban rinks worth a whirl.
Four urban rinks worth a whirl.
The Neon Museum in Las Vegas shines a light on the city's iconic signs.
The Austrian-born celebrity chef on the secret to a successful restaurant and how nothing beats the personal touch.
The jewellery designer, style icon and actor on the world's best tailors and where to eat Indian food in New York City.
In homage to the city's past, New York's new wave of German cuisine doesn't stop at sausage.
A second wave of innovation is hitting the home of Belgium's avant-garde.
The one-stop shop gets a modern-day update at these four spots.
The Canadian graphic artist on her favourite urban oasis and the power of linoleum.
With studios in London, Paris and beyond, our up-and-comers are finding the perfect fit internationally.


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Jackofalltrades, on 28 February 2013 - 08:58 PM, said:
You would be right, as I know several millionaires. Other's though, in that same class, seem to spend it recklessly.
Hard personal work to obtain wealth(careful with money), versus inheritance(loose with money)
My experience anyway from a very high-end golf club I used to work at.
Edited by pallidin, 28 February 2013 - 09:22 PM.


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Originally published Tuesday, February 19, 2013 at 9:20 PM
UW men's golfers taking charge at The Prestige | NW briefs
Washington's Chris Williams was tied for the individual lead and the Huskies men's golf team was in second place overall in Tuesday's second...
Washington's Chris Williams was tied for the individual lead and the Huskies men's golf team was in second place overall in Tuesday's second round of The Prestige at PGA West tournament in La Quinta, Calif.
Monday's first round was suspended by darkness and was completed Tuesday morning. Not all players completed the second round Tuesday. The final round is Wednesday.
Williams was 3-under par in the second round — with a double bogey on hole No. 2 but then six birdies the rest of the way. The Huskies trailed UCLA in the team standings but the Bruins still had a third of their second round to complete Wednesday morning.
Trevor Simsby, with a 2-under par round Tuesday, and Cheng-Tsung Pan of UW were tied for ninth.
"I'm really excited about our round," coach Matt Thurmond said. "Today was a test of our mental strength as a team."
Senior Charlie Hughes is 3-over and tied for 24th.
• Freshman Raychelle Santos claimed medalist honors for the second straight week and the Gonzaga women's golf team defended its title at the Folino Invitational Tuesday in Industry Hills, Calif. Santos, who won The Gold Rush in the spring opener last week, shot a final-round 1-under-par 70 for a 54-hole score of 218 to claim a 1-stroke victory over Aram Choi of Portland State. Gonzaga's Victoria Fallgren finished third.
• Seattle University lost to Portland 6-4 Tuesday night in a nonconference game at Bannerwood Stadium in Bellevue. Sean Narby of Auburn was 2 for 3 with a walk and a run scored for the Redhawks (1-3).
• Freshman Vicente Varas picked up a team-high sixth win of the spring and helped Gonzaga's men's tennis team down Eastern Washington 6-1 at the Spokane Racquet Club. The Bulldogs improved to 5-3 and Eastern Washington fell to 2-6.
From Web and school reports


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Chicago Cubs Not Contenders Yet
The Chicago Cubs improved dramatically so far this offseason, but they still have time before they can talk World Series. Read More
Grading Cubs' Signing Of Jon Lester
Was Jon Lester worth the 6 years and $155 million the Chicago Cubs gave him? Read More
Jake Peavy Will Be Next Move For Chicago Cubs
The Chicago Cubs broke the bank by signing Jon Lester and their next move will be bringing in Jake Peavy to further fortify their rotation. Read More
Grading The Cubs Trade For Miguel Montero
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5 Greatest Free Agents Cubs History
The Chicago Cubs fired up the hot stove Wednesday, signing Jon Lester to a six-year, $155 million contract. Check out the team's top free agents in league history. Read More
Justin Upton Would Put Cubs Over the Top
After signing ace Jon Lester, the Cubs are focusing their attention on Justin Upton. If they can land him, they will be a contender in the National League. Read More
James Shields Should Join Jon Lester With Cubs
The Chicago Cubs have become a contender with Jon Lester, and James Shields should seriously consider joining the team. Read More
Projecting Cubs' 2015 Rotation With Lester
After adding Jon Lester to the pitching rotation, the Cubs look like a very good team in 2015. Here's what their rotation looks like as of right now. Read More
5 Takeaways From Lester Signing With The Cubs
Jon Lester has signed with the Chicago Cubs, and that has far-reaching implications for the Cubs and the rest of the league. Read More
Cubs Signing Jon Lester The Ultimate All-In Move
Theo Epstein and the Chicago Cubs got their man, signing pitcher Jon Lester to a huge deal. Will it pay off with a title in 2015? Read More
Lester Signing Shows Cubs' Hunger To Contend
After signing ace Jon Lester, the Chicago Cubs are now contenders in the NL heading into 2015. Read More
Cubs Set To Land C Miguel Montero
The Chicago Cubs may have found their upgrade at the catcher position. Read More
5 Players the Cubs Should Still Try to Trade
The MLB offseason is coming to a close, but there are still moves to be made. Here are five players the Chicago Cubs could still look to move before opening day. Read More
Dealing For Hamels Makes Sense For Cubs
The Cubs have already added Jon Lester to their rotation, but if they want the best chance at a title over the next five years, they will trade for Cole Hamels as well. Read More
Colby Rasmus A Good Fit For Chicago Cubs
The Chicago Cubs have been connected to free agent outfielder Colby Rasmus recently. He could make a great platoon partner for youngster Arismendy Alcantara. Read More
Chicago Cubs Should Not Trade For Hamels
While the Chicago Cubs are trying to win now, they should hold off on trading for Cole Hamels. Read More
Cubs Make the Most Sense For Jake Peavy
Jake Peavy has plenty of options in free agency, but his best one is in Chicago. Joining the Chicago Cubs provides him opportunities few other teams can offer. Read More
Trading Travis Wood Makes Total Sense For Cubs
The Chicago Cubs are receiving interest in starter Travis Wood. Find out why they would be wise to move him if they can. Read More
Justin Upton Would Put Cubs Over the Top
After signing ace Jon Lester, the Cubs are focusing their attention on Justin Upton. If they can land him, they will be a contender in the National League. Read More
Jon Lester Wants $150 Million
Jon Lester has all the leverage this offseason, so he's reportedly upping his contract demands. Why not? Read More
Cubs Ensure Success By Not Trading Castro
It appears the Cubs are holding on to shortstop Starlin Castro for now, and that's the right decision by the front office. There's absolutely no reason to trade the star shortstop at this time. Read More
Cubs Not Listening To Offers For Castro Is Crazy
Starlin Castro has been rumored to be on the block for years, but with two shortstops ready to take over, the Chicago Cubs are rumored to be hanging on to him. This is a big mistake. Read More
Prediction For Cubs At 2014 MLB Winter Meetings
The Cubs were one of the most intriguing teams coming into the MLB offseason, but haven't done much yet. Expect that to change at the winter meetings next week. Read More
Lester May Reject Cubs Despite $135M Offer
The Chicago Cubs have reportedly offered Jon Lester a six-year deal worth more than $135 million. However, he may decide to sign somewhere else. Read More


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- 45Promote
Tote Bag
Our quality crafted Tote Bags are hand sewn in America using durable, yet lightweight, poly poplin fabric. All seams and stress points are double stitched for durability. Available in 13" x 13", 16" x 16" and 18" x 18" variations, the tote bags are washable, feature original artwork on both sides and a sturdy 1" wide cotton webbing strap for comfortably carrying over your shoulder.
What better way to celebrate your love of dinosaurs than with a loveheart shaped menagerie of prehistoric critters? c:
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12,109 views more info
Nirvana Albums, Discography
List of all Nirvana albums including EPs and some singles - a discography of Nirvana CDs and Nirvana records. List includes Nirvana album cover artwork in many cases, and if we are missing an album cover feel free to upload it in wiki fashion. This full Nirvana discography is alphabetical, however you can sort Nirvana album list by any column. Note that this complete list of Nirvana releases is based on official releases and does not always include promotional-only discs, although they are listed when we have data on them. List is made up of many different items, including Total Fucking Godhead and Classic Albums - Nirvana - Nevermind. You can use this factual list to create a new list, re-rank it to fit your opinion, then share it with your Twitter followers, Facebook friends or with any other social networks you use on a regular basis. (202 items)
The List
Rank Name
- 3
Songs of Love and Praise 1995
- 7
To Markos III 1970
- 35
Fatal Attraction 1994


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Updated: 07/02/2013 9:48 PM | Created: 07/02/2013 9:42 PM
Chef instructor Kerry Logan shows you how to make a fruit trifle perfect for 4th of July.
This Good Day New Mexico segment may include paid advertising content. It is not affiliated with KOB-TV's News Department.
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text: 5 Ways to Fix 3D Movies Low box office and complaining audiences have caused some to wonder if 3D's heyday is already over. Here, industry insiders such as James Cameron and Peter Jackson break down what's wrong with 3Dand how to fix it. By Erin McCarthy Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery Return to Gallery 6 of 6 Be PatientIt'll Get Better Truly, 3D in its current form is a separate entity from the kitschy 3D of decades past. And it is still relatively young. "3D, as a legitimate way to make movies, has only been around for four or five years," Cameron says. "We're the equivalent of the automotive industry in 1903. Certainly mistakes are going to be made and the market still needs to be fully defined." Cohen likens these growing pains to the early days of sound and color. "In silent pictures they had developed these fluid visual vocabularies," he says. "The early talkies were famous for doing these very staged scenes with random plants or lamps in the middle of the frame, because that's where they were hiding the microphones. It took awhile for technology to catch up to the point where they could do the same fluid, beautiful camera work that they had done for the silents. The same was true for color photography." Hollywood still has a lot to learn in terms of how to use the format creatively. "The form is still new, the technology is still evolving, and the technology hasn't caught up to the potential of the form," Cohen says. Most 3D movies these days have wide action shots, which is not ideal for the format because shooting far away decreases 3D and fast motion breaks it up. But increasing the frame rate from 24 frames per second up to 48 or even 60 frames per secondCameron's next big technological pushwill help with that. In fact, "Is 3D in trouble?" is really the wrong question. "The question is," Cohen says, "will it become more ubiquitous, or will it fall back to a state of just a few releases a year that are really special? I don't know the answer to that." Peter Jackson/New Line Cinema Return to Gallery Return to Gallery 0 SHARES 0 TWEET Return to Gallery Back Next Return to Gallery Return to Slideshow Related News Return to Slideshow


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The town of Avalon on Catalina Island
Pristine beaches, world class snorkling and beautiful hiking are difficult to find in the same place, but in Southern California, you can find all three on Catalina Island. Located just over 20 miles off the Los Angeles coast, Catalina never suffered the massive development of sprawling Southern California. As a result, it's an incredible place to escape from the city, and it only takes an hour long boat ride from ports at Marina del Rey, San Pedro, Long Beach and Newport Beach.
Catalina has five main campgrounds spread across the island as well as eleven primitive beach campgrounds accessible only by boat or kayak. Of the main campgrounds, Hermit Gulch is located within the main town of Avalon while Two Harbors Campground is adjacent to the village of Two Harbors on the other side of the island. While camping near a town might not seem desirable, the advantage is closer access to services like bike, snorkling and scuba rentals. Several small hiking trails can be found out of both sites.
Further off the beaten track, Little Harbor Campground is a beach-side location on the west side of the island. It's possible to take a bus here (which runs infrequently) or to make the hike from Avalon (16miles) or Two Harbors (about 7 miles). Prepurchased equipment rentals are also available here.
The two most primitive campgrounds are Black Jack and Parson's Landing. Located in the center of the island close to the highest point, Black Jack sits nestled in a pine forest, 1.3 miles from the main road which cuts across the island; numerous hiking trails spread out from around the campground which can be combined into various hiking loops. Parson's landing sits close to the island's far north point. Located on the beach, the site is a seven mile hike from Two Harbors. While wonderfully remote, even for Catalina, the site does not have fresh water so it's necessary to pack in enough for drinking and washing up.
In addition to these main campgrounds, numerous boat in campgrounds exist along the North/Eastern coast of the island between Avalon and Two Harbors. Since one of Catalina's main attractions lies beneath the water, this is a great way to copbine camping with kayaking, snorkling and swimming.
View Catalina in a larger map


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Robert Pattinson
fans rejoice: a brand new poster for
Bel Ami
has been revealed.
The new one sheet definitely exudes a
Dangerous Liaisons
vibe, with R-Pattz doing his usual soulful sulk while flanked by a bevy of well-attired ladies.
Check it out!
And as if that weren't enough, images from the film's world premiere in Berlin have also landed online. Pattinson attended the events with co-stars
Christina Ricci
and Holliday Grainger.
Check out a selection of pictures from the premiere, and press conference, below:
And if that wasn't enough
Bel Ami
for you, there's also a new clip to whet your appetite:
Bel Ami
opens in the UK on 9 March 2012. Keep up-to-date with at its
UK Facebook page
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Gambas al Ajillo - Garlic ShrimpEasy and tasty dish. Will definitely make it again. — sgrishka 4/8/2012 |
Italian Stuffed PeppersDelicious! There's no need to boil the peppers, they cook just fine on their own in the oven. I spread a little tomato sauce across the top of each pepper before putting the cheese on. — MichS220 3/27/2012 |
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Mar 18, 2014; Detroit, MI, USA; Detroit Red Wings center Gustav Nyquist (14) celebrates with center Riley Sheahan (15) after scoring a goal in the first period at Joe Louis Arena. Mandatory Credit: Andrew Weber-USA TODAY Sports
The only 10 Super Bowl recipes you will ever need
Forgot to plan a menu? We've got you covered.
Josh Gordon writes in open letter: 'I am not a drug addict'
Josh Gordon denied he had a drug problem and blamed his recent failed drug test on his age, upbringing and immaturity in a post on The (…)
Behind-the-scenes of ESPN's Super Bowl XLIX set in Arizona
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Robert Griffin III says God allowed his injury for a reason
Robert Griffin III had a rather disastrous 2014 season. The entire Washington Redskins organization had a pretty horrendous 2014 season (…)
Snickers' Super Bowl commercial stars Steve Buscemi and Danny Trejo
Steve Buscemi and Danny Trejo!
6 touchdown dances that stuck in football fans' heads
There are few surer ways for a football player to make an impression (for better or worse) than an elaborate touchdown celebration. All (…)
Provided by:Report: Jayson Werth will spend five days in jail for reckless driving
The Nationals outfielder was pulled over while driving 105 mph in a 55-mph zone.


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I almost feel guilty telling you to go to the movies this weekend, because at least half of this week's releases never had a chance. But on the brighter side, "9″ looks kind of amazing; "Tyler Perry's I Can Do Bad All By Myself" doesn't star Madea; "Whiteout" might help you survive an arctic murder mystery of your own one day; and characters you probably wouldn't like anyway die in "Sorority Row." Yay! Keep reading »
Zergnet: Simply Irresistible
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(05-08-2012 04:04 PM)cccupps420 Wrote: like the julio jones sp auth, got a leaf blue auto /25 of him
(05-09-2012 02:31 AM)BigBadBootyDaddy Wrote: I already have the blue /25, but I did send an offer your way as I saw something else I'm interested in. All other offers and messages returned.
(05-09-2012 04:30 AM)cccupps420 Wrote: just looked its actually the purple, its in my bucket under 2012 autos
(05-09-2012 12:30 PM)jkiddlridnour Wrote: What's the Rodgers-Cromartie dual GU #d to?
(05-09-2012 12:26 PM)titan fan Wrote: Check my bucket for the Julio lmk


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It has been quite a while since I have written about professional con artist Jennifer McKinney, known by some as MckMama from her blogging days. Previously, we have discussed her bankruptcy fraud (debts NOT discharged and forever payable by
Xyngular is a weight loss MLM (multi-level marketing) company which advertises quick, sustainable weight loss using their products. Last year I wrote a lengthy article about the Xyngular products, and I came to the conclusion that the products are
Xyngular Corporation recently sued Innutra LLC, a company that appears to be founded by a number of former Xyngers. You may recognize Xyngular as the company for which serial scammer Jennifer McKinney shills. Both companies are multi-level marketing companies
Yesterday Teresa Giudice and Guiseppi (Joe) Giudice were indicted by a federal grand jury in Newark, New Jersey on the following charges: Conspiracy to Commit Mail Fraud and Wire Fraud Bankruptcy Fraud Bankruptcy Fraud – Concealment Bankruptcy Fraud –
Several months ago I wrote an article on the Xyngular weight loss program being pimped by Jennifer McKinney (aka mommy blogger MckMama). The bottom line for me was that these programs do not work because: They create short-term weight
Readers of the Fraud Files are familiar with the story of Jennifer McKinney – – mommy blogger who calls herself MckMama – – who is prone to lies and exaggerations. She and her husband Israel were accused of lying
Jennifer McKinney – – former mommy blogger nicknamed MckMama – – has good news for the many creditors that she owes hundreds of thousands of dollars…. SHE CAN PAY THEM! This month's issue of Xyngular's Momentum magazine featured Jennifer
Multi-level marketing companies are getting lots of attention lately thanks to the Bill Ackman smackdown of Herbalife in December. MLMs offering "nutrition products" are of special interest to consumers, and with good reason. Companies like Isagenix, MonaVie , Usana,
For the last several months, we have been following the story of Jennifer "MckMama" McKinney and her bankruptcy filing from nearly a year ago. By spring, trustee Gene Doeling had her number, and was preparing to file a motion
Recently, watchers of the MckMama train wreck were treated to the news that blogger Jennifer McKinney has bought a home. This lovely home in West Salem, Wisconsin, was most recently on the market at $289,900. Jennifer "MckMama" McKinney bought