text:
Evaluation of enzyme inhibitors in drug discovery [electronic resource] : a guide for medicinal chemists and pharmacologists
- Author/Creator
- Copeland, Robert Allen.
- Language
- English.
- Edition
- 2nd ed.
- Imprint
- Hoboken, N.J. : Wiley, c2013.
- Physical description
- 1 online resource (xxxi, 538 p.)
Available online
- dx.doi.org Wiley Online Library
More options
- Bibliography
- Includes bibliographical references and index.
- Summary
- "There has been explosive growth in the hunt for new pharmaceutically agents globally. Traditionally, this has been the purview of the pharmaceutical industry, but today, this effort crosses academic, government, and industry laboratories across the world. Enzymes remain the most valued and common of drug targets; hence, a detailed understanding of their interactions with inhibitors is critical to successful drug discovery. This book provides a practical, readable, and comprehensive treatment of these topics that allows scientists to master the art of applied enzymology for drug discovery. The book addresses the opportunities for inhibitor interactions with enzyme targets arising from consideration of the catalytic reaction mechanism; discusses how inhibitors are properly evaluated for potency, selectivity, and mode of action, covers the potential advantages and liabilities of specific inhibition modalities with respect to efficacy in vivo, and provides valuable biochemical insights to help medicinal chemists and pharmacologists most effectively pursue lead optimization. It includes two new chapters, one on the pioneering idea of drug-target residence time fostered by Dr. Copeland, and the second on quantitative biochemistry. Five new appendices are added"--Provided by publisher.
Bibliographic information
- Publication date
- 2013
- Responsibility
- Robert A. Copeland.
- Note
- Machine generated contents note: Foreword.Preface.Acknowledgments.1. Why Enzymes as Drug Targets?1.1 Enzymes Are Essentials for Life.1.2 Enzyme Structure and Catalysis.1.3 Permutations of Enzyme Structure During Catalysis.1.4 Other Reasons for Studying Enzymes.1.5 Summary.References.2. Enzyme Reaction Mechanisms.2.1 Initial Binding of Substrate.2.2 Noncovalent Forces in Reversible Ligand Binding to Enzymes.2.2.1 Electrostatic Forces.2.2.2 Hydrogen Bonds.2.2.3 Hydrophobic Forces.2.2.4 van der Waals Forces.2.3 Transformations of the Bond Substrate.2.3.1 Strategies for Transition State Stabilization.2.3.2 Enzyme Active Sites Are Most Complementary to the Transition State Structure.2.4 Steady State Analysis of Enzyme Kinetics.2.4.1 Factors Affecting the Steady State Kinetic Constants.2.5 Graphical Determination of kcat and KM2.6 Reactions Involving Multiple Substates.2.6.1 Bisubstrate Reaction Mechanisms.2.7 Summary.References.3. Reversible Modes of Inhibitor Interactions with Enzymes.3.1 Enzyme-Inhibitor Binding Equilibria.3.2 Competitive Inhibition.3.3 Noncompetitive Inhibition.3.3.1 Mutual Exclusively Studies.3.4 Uncompetitive Inhibition.3.5 Inhibition Modality in Bisubstrate Reactions.3.6 Value of Knowing Inhibitor Modality.3.6.1 Quantitative Comparisons of Inhibitor Affinity.3.6.2 Relating Ki to Binding Energy.3.6.3 Defining Target Selectivity by Ki Values.3.6.4 Potential Advantages and Disadvantages of Different Inhibition Modalities In Vivo.3.6.5 Knowing Inhibition Modality Is Important for Structure-Based Lead Organization.3.7 Summary.References.4. Assay Considerations for Compound Library Screening.4.1 Defining Inhibition Signal Robustness, and Hit Criteria.4.2 Measuring Initial Velocity.4.2.1 End-Point and Kinetic Readouts.4.2.2 Effects of Enzyme Concentration.4.3 Balanced Assay Conditions.4.3.1 Balancing Conditions for Multisubstrate Reactions.4.4 Order of Reagent Addition.4.5 Use of Natural Substrates and Enzymes.4.6 Coupled Enzyme Assays.4.7 Hit Validation and Progression.4.8 Summary.References.5. Lead Optimization and Structure-Activity Relationships for Reversible Inhibitors.5.1 Concentration-Response Plots and IC50 Determination.5.1.1 The Hill Coefficient.5.1.2 Graphing and Reporting Concentration-Response Data.5.2 Testing for Reversibility.5.3 Determining Reversible Inhibition Modality and Dissociation Constant.5.4 Comparing Relative Affinity.5.4.1 Compound Selectivity.5.5 Associating Cellular Effects with Target Enzyme Inhibition.5.5.1 Cellular Phenotype Should Be Consistent with Genetic Knockout or Knockdown of the Target Enzyme.5.5.2 Cellular Activity Should Require a Certain Affinity for the target Enzyme.5.5.3 Buildup of Substrate and/or Diminution of Product for the Target Enzyme Should Be Observed in Cells.5.5.4 Cellular Phenotype Should Be Reversed by Cell-Permeable Product or Downstream Metabolites of the Target Enzyme Activity.5.5.5 Mutation of the Target Enzyme Should Lead to Resistance or Hypersensitivity to Inhibitors.5.6 Summary.References.6. Slow Binding Inhibitors.6.1 Determining kobs: The Rate Constant for Onset of Inhibition.6.2 Mechanisms of Slow Binding Inhibition.6.3 Determination of Mechanism and Assessment of True Affinity.6.3.1 Potential Clinical Advantages of Slow Off-rate Inhibitors.6.4 Determining Inhibition Modality for Slow Binding Inhibitors.6.5 SAR for Slow Binding Inhibitors.6.6 Some Examples of Pharmacologically Interesting Slow Binding Inhibitors.6.6.1 Examples of Scheme B: Inhibitors of Zinc Peptidases and Proteases.6.6.2 Example of Scheme C: Inhibition of Dihydrofolate Reductase by Methotresate.6.6.3 Example of Scheme C: Inhibition of Calcineurin by FKBP-Inhibitor Complexes.6.6.4 Example of Scheme C When Ki* << Ki: Aspartyl Protease Inhibitors.6.6.5 Example of Scheme C When k6 Is Very Small: Selective COX2 Inhibitors.6.7 Summary.References.7. Tight Binding Inhibitors.7.1 Effects of Tight Binding Inhibition Concentration-Response Data.7.2 The IC50 Value Depends on Kiapp and [E]T.7.3 Morrison's Quadratic Equation for Fiting Concentration-Response Data for Tight Binding Inhibitors.7.3.1 Optimizing Conditions for Kiapp Determination Using Morrison's Equation.7.3.2 Limits on Kiapp Determinations.7.3.3 Use of a Cubic Equation When Both Substrate and Inhibitor Are Tight Binding.7.4 Determining Modality for Tight Binding Enzyme Inhibitors.7.5 Tight Binding Inhibitors Often Display Slow Binding Behavior.7.6 Practical Approaches to Overcoming the Tight Binding Limit in Determine Ki.7.7 Enzyme-Reaction Intermediate Analogues as Example of Tight Binding Inhibitors.7.7.1 Bisubstrate Analogues.7.7.2 Testing for Transition State Mimicry.7.8 Potential Clinical Advantages of Tight Binding Inhibitors.7.9 Determination of [E]T Using Tight Binding Inhibitors.7.10 Summary.References.8. Irreversible Enzyme Inactivators.8.1 Kinetic Evaluation of Irreversible Enzyme Inactivators.8.2 Affinity Labels.8.2.1 Quiescent Affinity Labels.8.2.2 Potential Liabilities of Affinity Labels as Drugs.8.3 Mechanism-Based Inactivators.8.3.1 Distinguishing Features of Mechanism-Based Inactivation.8.3.2 Determination of the Partition Ratio.8.3.3 Potential Clinical Advantages of Mechanism-Based Inactivators.8.3.4 Examples of Mechanism-Based Inactivators as Drugs.8.4 Use of Affinity Labels as Mechanistic Tools.8.5 Summary.References.Appendix 1. Kinetic of Biochemical Reactions.A1.1 The Law of Mass Action and Reaction Order.A1.2 First-Order Reaction Kinetics.A1.3 Second-Order Reaction Kinetics.A1.4 Pseudo-First-Order Reaction Conditions.A1.5 Approach to Equilibrium: An Example of the Kinetics of Reversible Reactions.References.Appendix 2. Derivation of the Enzyme-Ligand Binding Isotherm Equation.References.Appendix 3. Serial Dilution Schemes.Index.
- Available in another form
- Print version: Copeland, Robert Allen. Evaluation of enzyme inhibitors in drug discovery 2nd ed. Hoboken, N.J. : Wiley, c2013 9781118488133 (DLC) 2012045179
- 9781118540404
- 1118540409
- 9781118540282
- 9781118354483
- 1118354486
- 9781118540398
- 1118540395


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Ex-Tempe police officer pleads guilty to theft
PHOENIX -- A former Tempe patrol officer accused of stealing police property and cash last year has pleaded guilty in the case.
Maricopa County prosecutors said Aaron Smith entered his plea Friday and will be sentenced on June 7.
Smith was arrested last July after a month-long internal investigation on suspicion of theft, burglary and tampering with physical evidence.
Tempe police said they began to get reports of missing items in early July.
They said Smith had access to the areas where the property disappeared and his swing-shift hours matched up with when the items went missing.
Detectives later found two stolen police bicycles when they served search warrants at Smith's home, vehicles and work locker.
They said Smith admitted to stealing the property and claimed he was under extreme financial hardship.
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Gear Review
Christian Paul
It is back!
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text:
September 2011, Volume 75, Issue 2, pp 223-236,
Open Access
This content is freely available online to anyone, anywhere at any time.
22 Jun 2011
Basic and Refined Nomic Truth Approximation by Evidence-Guided Belief Revision in AGM-Terms
- Theo A. F. Kuipers
- … show all 1 hide
Straightforward theory revision, taking into account as effectively as possible the established nomic possibilities and, on their basis induced empirical laws, is conducive for (unstratified) nomic truth approximation. The question this paper asks is: is it possible to reconstruct the relevant theory revision steps, on the basis of incoming evidence, in AGM-terms? A positive answer will be given in two rounds, first for the case in which the initial theory is compatible with the established empirical laws, then for the case in which it is incompatible with at least one such a law.
- Alchourrón, C., Gärdenfors, P., & Makinson, D. (1985). On the logic of theory revision: partial meet contraction and revision functions. Journal of Symbol Logic, 50(2), 510–530.
- Cevolani, G., & Calandra, F. (2009). Approaching the truth via belief change in propositional languages. In M. Suárez, M. Dorato, & M. Rèdei (Eds.), EPSA epistemology and methodology of science. Launch of the European philosophy of science association, Ch. 5. Berlin: Springer.
- Cevolani, G., Crupi, V., & Festa, R. (this volume). Verisimilitude and belief change for conjunctive theories.
- Grove, A. (1988). Two modelings for theory change. Journal of Philosophical Logic, 17, 157–170. CrossRef
- Hansson, S. O. (1999). A textbook of belief dynamics. Dordrecht: Kluwer AP.
- Kuipers, T. (2000). From instrumentalism to constructive realism. On some relations between confirmation, empirical progress, and truth approximation, Synthese Library 287. Dordrecht: Kluwer AP.
- Niiniluoto, I. (1999). Belief revision and truthlikeness. In: Spinning ideas, electronic essays dedicated to Peter Gärdenfors on his fiftieth birthday.
- Rabinowicz, W. (1995). Global belief revision based on similarities between possible worlds. In Hansson and Rabinowicz (Eds.), Logic for a change. Essays dedicated to Sten Lindström on the occasion of his fiftieth birthday (pp. 80–105). Uppsala Prints and Preprints in Philosophy 1995–1999, Department of Philosophy, Uppsala University.
- Zwart, S. D. (2001). Refined verisimilitude. Synthese Library 307. Dordrecht: Kluwer AP.
- Title
- Basic and Refined Nomic Truth Approximation by Evidence-Guided Belief Revision in AGM-Terms
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Journal
Volume 75, Issue 2 , pp 223-236
- Cover Date
- 2011-09-01
- 10.1007/s10670-011-9292-0
- Print ISSN
- 0165-0106
- Online ISSN
- 1572-8420
- Publisher
- Springer Netherlands
- Additional Links
- Topics
- Authors
- Author Affiliations
- 1. Department of Theoretical Philosophy, University of Groningen, Groningen, The Netherlands


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This recipe is brought to you by the American Heart Association's Patient Education program. Recipe copyright © 2010 by the American Heart Association. Look for other delicious recipes in American Heart Association cookbooks, available from booksellers everywhere, and at www.heart.org/recipes.
Desserts and baked goods need not be forbidden fruit in a heart-healthy diet. This selection of light, fruit-based treats includes breakfast, snacks and dessert.
Serves 12; 1 muffin per serving
These flavorful muffins are a great way to fit fruit and fiber into a portable treat for breakfast or a quick snack.
1 cup whole-wheat flour
1 cup unprocessed wheat bran
½ cup sugar
1 teaspoon baking soda
¾ teaspoon ground cinnamon
½ teaspoon baking powder
¼ teaspoon salt
6 ounces fat-free plain yogurt
2 tablespoons canola or corn oil
1 large egg white
1 teaspoon vanilla extract
1 8-ounce can crushed pineapple packed in its own juice, undrained
1 medium carrot, shredded
Preheat the oven to 400°F. Line a 12-cup muffin pan with paper bake cups. Set aside.
In a large bowl, stir together the flour, wheat bran, sugar, baking soda, cinnamon, baking powder, and salt. Make a well in the center.
In a medium bowl, whisk together the yogurt, oil, egg white, and vanilla until well blended. Stir in the pineapple with liquid and the carrot. Pour into the well in the flour mixture, stirring until the mixture is just moistened but no flour is visible. Don't overmix; the batter should be lumpy.
Spoon enough batter into the bake cups to fill each about three-fourths full.
Bake for 18 to 20 minutes, or until a wooden toothpick inserted in the center comes out clean. Serve warm or at room temperature.
Unprocessed wheat bran is the bran removed from wheat kernels. A very good source of fiber, it makes a healthy, flavorful addition to many foods, including meat loaf, burgers, and baked goods such as muffins, breads, and cookies. Health food stores and many supermarkets carry unprocessed wheat bran, usually stocked near the oats.
(per serving)
Calories 120
Total Fat 2.5 g
Saturated Fat 0.0 g
Trans Fat 0.0 g
Polyunsaturated Fat 1.0 g
Monounsaturated Fat 1.5 g
Cholesterol 0 mg
Sodium 143 mg
Carbohydrates 23 g
Fiber 4 g
Sugars 12 g
Protein 3 g
1½ starch
© 2011 American Heart Association, Inc.
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text: We just had dinner on the 25 July 2012. We had entree, main course and dessert. I love this restaurant very much, definitely going back next time. The ambient was great, huge space and tidy. Staffs were extremely polite and helpful. We ordered a mix entree which was a bit small portion for 3 people but i still loved it.... More


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Family Fun Days
Sat, Aug 31 - Mon, Sep 2, 2013
Times: 9:30-5:00
Venue: Old Sturbridge Village
1 Old Sturbridge Village Road, Sturbridge, MA 01566
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Before summer winds down, families come to the Village for some old-fashioned fun. Play games, make crafts, launch toy fire-balloons, and see our craftsmen at work.
Rock Harbor: An Off-Season Gem on Cape Cod
The 'season' on Cape Cod typically lasts from Memorial Day through Labor Day, although...
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Footwear News
FN Summit 2012
FN Summit
Hot designers and bold entrepreneurs revealed how a powerful combination of vision and passion put them on the path to success. Each of their stories — from Blake Mycoskie on the rise of Toms to Stuart Weitzman's career-defining moments — drove home a single point: To be successful in today's tough retail environment, executives must transform the status quo.
Videos of the presentations are available at FNSummit12.FORA.tv.


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Hot ringtones on Audiko.net! Just download a free Didier Super ringtones for your iPhone or mobile. Suit yourself your favorite episode from your favorite piece of art - Ingénieur Informaticien, Arrete de te la peter, Putain de Chinois, or any other track. Then download the prepared Didier Super ringtones to your iPhone, and enjoy Humour music by Didier Super every time your phone rings. If you are mad with Humour or maybe Punk and Humour Francais music, then you will probably like Mickey 3D, Renaud, or La Chanson du Dimanche as well. For all who want a free Didier Super ringtone, we also recommend listening to Chanson Francaise, français, and Chanson. Here you can download your tune both in the MP3 and m4a formats, compatible with both mobile phones and iPhones. Just select a track, and choose free Didier Super ringtones download option.
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Pyne defends appointment of Labor education critics
PUBLISHED: 10 Jan 2014 09:08:00 | UPDATED: 10 Jan 2014 12:21:29PRINT EDITION: 10 Jan 2014Education Minister Christopher Pyne says the three cross-curriculum priorities of indigenous history and culture, engagement with Asia and sustainability would be re-examined to ensure they are useful. Photo: Alex Ellinghausen
Joanna Mather
Education Minister Christopher Pyne has defended his decision to appoint critics of Labor's school funding reforms to review the national curriculum.
Mr Pyne announced on Friday that Kevin Donnelly, a former teacher, and University of Queensland professor Ken Wiltshire would review the curriculum and report to him in May or June. Changes would be ready in time for the beginning of the 2015 school year.
Dr Donnelly is a senior research fellow at the Australian Catholic University and former chief of staff to Liberal frontbencher Kevin Andrews.
He has written extensively on education issues. He believes the real problem in classrooms is rowdiness among students and that Australian children have been let down by a schooling system has given them an "inflated sense of their ability".
Dr Donnelly has heavily criticised Labor and its Gonski changes.
He has also lamented what he says is a desire by the Greens to "enforce a secular agenda on schools" and in 2010 wrote in relation to a booklet about Islamic perspectives in Australian schools that "some world views are preferable to others and some religious and cultural practices are un-Australian".
Mr Pyne said not everybody shared Dr Donnelly's views, but he was chosen for his intelligence and experience. "I'm very confident that Ken and Kevin will bring a balanced approach," he said.
Professor Wiltshire is the J.D. Story Professor of Public Administration and Leader of the Not for Profit Unit at UQ Business School. His research interests are in the fields of public policy and public sector management.
He has described the Labor government's handling of school funding reforms as a "disgrace".
Appearing alongside Mr Pyne in Adelaide on Friday, Dr Donnelly said he was a "curriculum nerd".
Australia should look to other high-performing countries in Asia and Europe for insights into successful curricula development, he said.
The national curriculum for English, maths, science and history has been finalised. Other subjects are yet to be finalised.
Mr Pyne also said the three cross-curriculum priorities of indigenous history and culture, engagement with Asia and sustainability would be re-examined to ensure they are useful.
Asked about one of the most contentious issues related to the curriculum, history teaching, Mr Pyne said students should be taught about the nation's indigenous and colonial roots to "celebrate Australia" overall.
Read more
People | Christopher Pyne, Kevin Andrews |
Topics | Education, Politics /Federal Politics |


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Barcelona are keeping tabs on two of Tottenham's rising stars, according to a report in the Daily Star.
Both Tottenham and Barcelona are in Group 1 of the NextGen Series competition, where youngsters from Europe's top clubs come face-to-face. After five games, Spurs are second, level on points with Barca, following a 4-1 away win for the Lilywhites last time around.
On target that day was Shaquille Coulthirst, who netted a hat-trick, while Alex Pritchard also scored his fourth of the competition.
The report claims the Spanish giants have been impressed with the performances of the duo, and will look to bring them to La Liga.
Pritchard, 19, has his contract expiring at the end of the season, meaning he will be able to leave, with compensation payable. QPR have recently been linked with signing the player.
Coulthirst was top scorer for the Under-18s last season, netting 11 goals in 21 appearances.
See what the expert tipsters at OLBG are tipping on Tottenham v West Ham
Chelsea striker Costa hit with violent conduct charge
Arteta signs new contract with Arsenal
Aston Villa given boost in pursuit of Man City's Sinclair
PSG considering loan move for Adebayor
Tottenham manager Mauricio Pochettino won't drop Vorm for FA Cup blunder
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Dr. Hunter Heath, MD
Endocrinology, Diabetes & Metabolism, Indiana University Medical Center Endocrinology
- 541 Clinical Dr Ste CL459
Indianapolis, IN 46202 - 1 Office Location
- (317) 274-1339
Dr. Hunter Heath graduated from the Washington University School of Medicine in 1968. He works in Indianapolis, IN and specializes in Endocrinology, Diabetes & Metabolism. Dr. Heath is affiliated with IU Health University Hospital and Eskenazi Health.
Gender: Male
Years in Practice: 47 Years
Languages Spoken: English
Medical School: Washington University School of Medicine
Graduation Date: 1968
Hospital Affiliations: IU Health University Hospital, Eskenazi Health
Specialties: Endocrinology, Diabetes & Metabolism


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Channel 6 News - Search Results
(WWMT) -- Lyme Disease is not the only reason to avoid ticks. Doctors say one of those bites may also make you allergic to red meat.
Researchers have found the allergic reaction can come after a bite from the "lone star tick." But it doesn't set in until three to six hours after you eat red meat for the first time after getting bit. The tick is listed as one of the three most common ticks in Michigan, according to the New York State Department of Health.
"Lone star ticks are becoming more common in New York State. They can carry the germ that causes human monocytic ehrlichiosis and are another rash illness that has been seen in over 20 other states. Adult female lone star ticks have a white dot on their back and are similar in size to deer ticks. They are most active from April through July."
[Click here] for more information on ticks.


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Rain Catcher? Anyone?
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Telstar 28
Join Date: Mar 2006
Location: New England
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Not on this planet... most rain is caused when moisture condenses around small particulates in the air... that would tend to indicated to me, that the rain has a fair bit of particulate matter in it. This doesn't even address issues like chemical pollutants, like sulphur dioxide, one of the primary components of acid rain, volcanic ash, airborne dust from drought stricken areas or a million other sources of pollution. Airborne pollution can travel long distances, so the water from rainstorms over the open ocean isn't much better than that near coastal areas. Go ahead, get a bucket and catch some rainwater in, and cover it and leave it sitting in the sun for a week. It won't be the "clean" water you think it is after that time is my guess. Plenty of pollen, microbes, mold spores, etc in that rain water.
Originally Posted by
RAIN WATER would seem to be naturally clean and pure most places. Water gets dirty when it hits the ground etc. Air generally contains very few bacteria etc. Bird poop etc is the most likely source of contamination. If you have a dedicated rain catcher that is stored clean until needed I doubt that any treatment is required..most places. Clean water does not support the growth of bacteria or algea. Microbes require nutrients such as phosphorus and nitrogen. rain usually does not contain many nutrients. I mean really rain is close to being distilled water!!!!!!
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Telstar 28
New England
You know what the first rule of sailing is? ...Love. You can learn all the math in the 'verse, but you take
a boat to the sea you don't love, she'll shake you off just as sure as the turning of the worlds. Love keeps
her going when she oughta fall down, tells you she's hurting 'fore she keens. Makes her a home.
Cpt. Mal Reynolds, Serenity
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Pay Range 23 Breakdown
Breakdown | Min | Max |
Annually | $64,045.82 | $96,068.74 |
Monthly | $5,337.15 | $8,005.73 |
Bi-Weekly | $2,463.30 | $3,694.95 |
Hourly (40 hrs.) | $30.7913 | $46.1869 |
Hourly (42 hrs.) | $29.3250 | $43.9875 |
Hourly (56 hrs.) | $21.9938 | $32.9906 |
Purchasing Manager
Range: $64,045.82 - $96,068.74 (23)
Position Number: 1662
JOB SUMMARY: This position is responsible for managing the procurement and warehousing functions of the city.
Establishes general goals for the warehousing and purchasing functions of the city; manages database programs to track and verify goals.
Forecasts inventory requirements; forecasts commodity costs for budgeting; administers the city's procurement program; prepares purchasing and surplus activities reports.
Reviews drafts of RFP or proposed contract; makes recommendations for compliance with state or city policies.
Reviews specifics of questionable transactions and takes remedial actions as necessary.
Trains, schedules, assigns, directs, supervises, and evaluates personnel.
Meets with City Council for award of bids, sale of surplus and other matters.
Conducts purchasing workshops for city employees.
Meets with citizens to discuss bid opportunities and surplus sales.
Meets with architects and engineers to discuss bids.
Performs other related duties as assigned.
Knowledge of the principles and practices of municipal purchasing activities.
Knowledge of the principles and practices of computerized financial information management.
Knowledge of relevant federal and state laws, city ordinances, and department policies and procedures.
Skill in utilizing financial computer software programs.
Skill in management and supervision.
Skill in operating office equipment such as a computer and calculator.
Skill in oral and written communication.
SUPERVISORY CONTROLS: The Financial Information Services Director assigns work in terms of division goals. The work is reviewed through conferences, reports, audits, and observation of division activities.
GUIDELINES: Guidelines include city personnel and purchasing policies, written contracts, architect's specifications, relevant federal and state laws and city ordinances, and city and department policies and procedures. These guidelines require judgment, selection, and interpretation in application.
COMPLEXITY: The work consists of varied management duties. The need to follow specific guidelines contributes to the complexity of the work.
SCOPE AND EFFECT: The purpose of this position is to manage the purchasing and warehousing operations of the city. Successful performance helps ensure the effectiveness of all city operations.
PERSONAL CONTACTS: Contacts are typically with co-workers, other city employees, elected officials, department heads, architects, vendors, state officials, and the general public.
PURPOSE OF CONTACTS: Contacts are typically to give or exchange information, resolve problems, provide services, and justify, negotiate, or settle matters.
PHYSICAL DEMANDS: The work is typically performed while sitting at a desk or table or while intermittently sitting, standing or stooping.
WORK ENVIRONMENT: The work is typically performed in an office, stockroom, or warehouse.
SUPERVISORY AND MANAGEMENT RESPONSIBILITY: This position has direct supervision over Buyer (2), Purchasing Technician (1), and Warehouse Technician (3).
Knowledge and level of competency commonly associated with the completion of a baccalaureate degree in a course of study related to the occupational field.
Experience sufficient to thoroughly understand the diverse objectives and functions of the subunits in the division/department in order to direct and coordinate work within the division/department, usually interpreted to require three to five years of related experience.
Ability to be bonded.


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[CLOSED] 270 point 'Christmas Spirit Giveaway'Well, it's been awhile since I've been here at deviantART. How I missed thee! Guess I needed a break from it to fully concentrate because it was a little bit of a distraction from school. But, with that behind me, I'm planning on being active again. If you so happen to stumble upon this journal entry, I'm going to let you in on a little secret.I'm currently having a...........Christmas Spirit Giveaway!Deadline to enter: December 23rdDrawing to take place on December 25thIn this season of giving, I will be giving deviants a chance to win some prizes. These prizes will be different size point prizes. Now how can you participate in this great giveaway? Check the info below How To Enter The Giveaway (Free ticket for participating) Send a note or comment, provide either your profile, deviation, contest, kir
Happy Holidays Giveaway!! WINNERS!!EDIT: Okiiii! Time for the moment you have all been waiting forrr! The winners are!!!47 :iconchibichoco23: wins an icon! 3 :iconKibame: wins a chibi! 26 :iconAngelMarieTuran: wins a bust sketch. 50 :iconPearlDePalkia: wins a 1 month premium.Thank you all for participating! I hope everyone has a safe and happy holiday break! So, since the holidays are just around the corner I thought I too would hold a holiday giveaway of sorts!Anyone can participate! Watchers and non-watchers alike! All you have to do is:1. Fav this journal. (if you make a journal or pole spreading the word I would eternally love you! )2. Comment and tell me what you plan on doing for your holiday break!3. Have a good holidayyyy. c: Prizes will be announced on the 24thhh.Now for the good stuff, the PRIZES! There are 4!!ONE person will win an icon in this style!!! ONE person will win a fully coloured digital chibi.ONE
done ._.yep ill post the results soon
150 POINTS GIVEAWAY ! *CLOSED*Why the heck not !? We have decided that we should organize a Points Giveaway with the points that have been donated by you, the fellow members of ContributeArt, on the CAdonations profile. The rules are :1. You must watch Dzolee and thecauldronofjewelry (we will check)2. You must Favourite this Journal3. You must share this Journal in a Journal or Poll4. When you're done with the rules above, come back here and post a comment with a link to your Poll or Journal and we will give you a number and add you to the Participants List IF YOU DON'T FOLLOW ALL THE RULES YOU WILL BE KICKED OFF THE GIVEAWAY! The prizes are :1st place : 80 + 3 Watchers 3 Llamas and 10 favs from Dzolee,
POINTS GIVEAWAY!!!:iconcannotevenplz::iconcannotevenplz::iconcannotevenplz:POINTS GIVEAWAY!!!!!100TO JOIN THIS GIVEAWAY YOU MUST:WATCH MEFAV THIS JOURNALFAV EITHER: or (Or both :3)COMMENT "Done" In the comments belowBe cool :icongagaplz:DEADLINE: December 28th, 2014:iconatnightplz:(MAY BE EXTENDED)BEST OF LUCK TO EVERYONE!!!
Membership give away -winner-And the winner isMelmee :iconMelmee:on a side note if you want a feature I do take donations:if you donate I'll feature you1 - 5 1 feature6 - 10 2 features11 - 20 5 features21 - 50 10 features51+ have there own featured journal
RAFFLE [Winners]The winners are:1) #111 - paichi2) #292 - KeyboardingChihuahua3) #273 - EmadraThanks a billion to all those who participated! If I didn't llama you yet, just say so! I couldn't have done it without every single one of you~! Winners: NOTE the contributors to claim your prize!Here are the rules [or directions]: Comment that you will enter. Don't back out without notifying me, PLEASE. It will make life easier. Participate by 12/16/2012 Sunday, 12:00 noon PST The prize First A one-month premium membership from me 10 points from alterene A llama from Arlesienne, Enya-Adoptables, brainspewage, ArchaicLullabies, and GreenieCake :bulletwhit
Good Intention: PMs and Points Giveaway!:icongood-intention:In celebration of the incredible momentum that this group has gained in just a couple of days, I am holding an Introductory Giveaway!About The Group:Good-Intention is a group dedicated to the kind acts that take place daily around the deviantART community. From users spending their time on free resources, to those who choose to feature the artwork of others. No act is too small or too minor to not have a spotlight shone on it.Prizes: (1) - 1 Year Premium Membership (Or 2,396 ) (3) - 3 Month Premium Memberships (Or 636 ) (5) - 1 Month Premium Memberships (Or 396 ) (10) - 100 Prizes will be selected using: http://jklp.org/public/html/choose.html for impartiality.In the spirit of giving, you may elect to give your prize to another user on deviantART.
Help needed CI Give away ends 30th of SeptemberAttention Deviantart changed the rules and I cannot longer give someone a 3 month Premium membership it's not possible anymore sadly edit: they brought them back the 3 month Premium membership so I can give them again :3for those of you who do not know, I, *Tsuki-SoraRuki:decide to do a projectcalled project weekly give away here you can win Pm's for free how can I enter ?to enter simply fave this journalfeel free to share this journal with your friends or watcherswhat are the weekly prizes?1 month premium membership (for one lucky member3 month premium membership(for one lu
Membership Giveaway! ENDED Im out right now, but I'll announce the winner when I get home!I've decided to do a membership giveaway and it's open to ANYONE.The final date is October 20th, Noon, Pacific Time. Rules:You get more chances if you do one or all four of these things. Favorite this journal. +1 Make a journal linking to this journal. +1 (make sure you comment and let me know!) Comment on this journal. +1 Watch me. +1 (if you already do, you already get 1 point.)At the end, I'll put all the points together and put your name that many times in the randomizer, giving you more chances to win. (I will be using http://www.random.org/lists/ to choose).If you do all of the ways, I give you 4 chances to win!The prize? A 12 month premium membership!Good luck, everyone!Be friendly, or I kick you out.Edit: Please don't hate me if I don't comment. I'm reading all the comments, I swe
Point Giveaway + Free Feature [NYE - ended]EDIT: Winners have been found & announced; congratulations!Thanks to all participators - don't remove this from your Favourites yet;Donators have signed up to give you llamas for being part of my giveaway~Slowly but surely 2012 is ending - things will end, others will be begin, which means:Yup, I'm doing another giveaway and stepping up on the prizes once again Further more, there are extra chances to gain points~ and free features too, of course!*The Prizes: 1st place - 110 points (1 winner):iconStarija: 2nd place - 60 points (2 winners):iconpsycho-gummybearz: :iconShadowMiori: 3rd place - 30 points (4 winners):iconNynjaKat: :iconHalfInane-HalfMental: :iconIdellechi: :iconTheAnimeAddiction: 4th place - 15 points (10 winners):icondfox20: :iconmrunu95: :iconmisarieski: :iconLa-Nee: :iconmimiseor::iconShining-in-Darkness: :iconhappypurinsu: :iconMissMightyEagle: :iconStupidInLove: :iconmiloduh:- an
Friendship Giveaway - 2000 dA Points [Closed]This month's giveaway is a little different. If you win, you don't get the points. What?! Yes, this month's giveaway is about friendship! If you win the giveaway you may choose a friend who will receive the points. Your friend will receive the points with a note that they are from you!Friendship Giveaway <3 PrizesGrand Prize - 1000 dA Points(2) Runners-Up - 500 dA PointsHow to EnterJust +fav this journal! RulesYour account must be at least 2 months old as of February 23rd.No spamming or beggingGiveaway Ends February 23rd----------------------------------------------------TwitterFor alerts on my upcoming projects and contests, you should follow me on Twitter. I am AutodidactLaura.AutodidactivistI'm happy to announce one of my pet projects, Autodidactivist.com, will be online in April
help needed weekly give away ends 25th MarchRules have been changed if you want to enter this weekly give awayit's requirement to fav this journal!Edit: that means you don't need to write 5 comments anymorebut it's still allowed if you want to :3for those of you who do not know, I, *Tsuki-SoraRuki:decide to do a projectcalled project weekly give awaybut guys I really need help to continue with my projecthelp me out by donating points at Tsuki-SoraRukior click on the button<strong>
Help needed CI Give away ends 23nd of SeptemberAttention I need lots of support to keep running this project so if you have some couple of points to spare please donate them at my profile.Tsuki-SoraRuki or mariridoodleparadisefor those of you who do not know, I, *Tsuki-SoraRuki:decide to do a projectcalled project weekly give away here you can win Pm's for free how can I enter ?to enter simply fave this journalif you want to share this journal I will be deeply appreciative ,but it's not requiredwhat are the weekly prizes?1 month premium membership (for one lucky member3 month premium membership(for one lucky memberhowever...... I need lots of support
Comments giveaway project + 100 points!The winner:_____________________________________________________________please, support this journal with simple so more people can see it _______________________________________________________________Hello, dear deviants!Do you want more constructive feedback? You can get it for free.In order to participate you only have to:fav this journalandcomment on it.I will make sure I visit your page and comment on one of your deviations, giving it a constructive comment/critique.+one lucky deviant who participates in this project will get 100 points _Why am I doing this?I'm trying to show to deviants a real value of good feedback. It's something we should all learn to appreciate, when the comments aren't just pure words like awesome, wow, good, cool...Deviantart is a big community with many exposed/underexposed artists but all of us are the same when it comes to getting feedback. We all get good and bad.N
GIVEAWAY WINNERS!WINNERS!154: surge64 ----> PROOF: http://img14.imageshack.us/img14/9545/154esp.jpg45: GamerGirl14 ----> PROOF: http://img685.imageshack.us/img685/293/45693172.jpg157: sarafina10 ----> PROOF: http://img600.imageshack.us/img600/8890/157rn.jpgPROOF OF NUMBERS ----> http://img14.imageshack.us/img14/8210/numbersw.jpgThank you all for joining! Happy Holidays~! --------Hey guys! It's the season for giving, so I'm a doing a premium membership giveaway!YOU CAN WIN A 3 MONTH PREMIUM MEMBERSHIP!However... I am not just giving away one, not two, but THREE premium memberships!HOW TO ENTER? Please this journal to enter!HOW TO GET MORE ENTRIES? Advertise this giveaway in your journal! = +2 entriesI will be using a random number generator to pick 3 numbers.I will post screenshots of the numbers.THIS GIVEAWAY ENDS ON DECEMBER 15 AT 6pm GMTGood luck!*** If less th


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Hawthorne's Backyard's culinary architects animate the American fare, such as burgers, ribs, and roasts, depicted on the menu. An appetizer of loaded chili cheese fries, which swim in green onions and sour cream ($5.99), can prep palates for an appointment with a hearty entree. Momma's pot-roast sandwich, a pulled-pork tenderloin cooked in homemade barbecue sauce and set inside a hoagie bun, frolics across taste-bud territory ($8.50), and the backyard double cheeseburger dually satiates meat and dairy yearnings ($10.50). A full slab of signature baby-back ribs comes to tables drenched in barbecue sauce and, like a subpoena from a grandmother, is served with cinnamon apples and sweet-potato fries ($18.99).
Beneath the night sky's smattering of stars, Cascade Drive-In projects double features of the latest first-run films. Customers tune car radios to 88.5 FM or attach celebrity impersonators to their car windows to hear audio synchronized to the narratives unfurling onscreen. Throughout the evening, moviegoers can chow down on Cascade Drive-In's concessions or dump their own charcoal into the theater's onsite grill to simmer feasts for friends gathered in the picnic area.
At Bulldog Ale House, frothy suds and robust spirits flow from an expansive full-service bar to complement a hearty menu of all-American pub grub. Crisp tortilla chips plunge into pots of scratch-made queso, priming palates for hearty feasts alongside other meal starters such as the supergrandeplatter, a shareable plate piled high with boneless wings, mini corn dogs, and fried favorites such as mozzarella sticks and onion rings. Like a toddler's temperament, spicy buffalo wings offer diners mild to atomic eruptions according to their tolerance, and the pub's eight signature sauces, including Cajun and lemon-pepper, also await to dress hand-breaded chicken tenders and dry beards.
Owned by the Irish-pub experts behind The Kerry Piper and Tommy Nevin's, Muldoon's flaunts a deep-rooted pub pedigree. It doesn't need its restaurant brethren to prove that, though—the menu speaks for itself. Above the pub's weathered-wood floorboards that reflect the glow of stained-glass light fixtures, a parade of steaming plates brings forth such classics as shepherd's pie, corned beef and cabbage, and Harp-beer-battered fish 'n' chips. There are more unusual flavors to taste, as well. Take Muldoon's signature burgers, for instance, which are made from half-pound Angus beef patties that chefs pile with blue cheese and fried onions, smother in guacamole and grilled mushrooms, or stuff with oozing morsels of cheddar cheese and jalapeños. Meanwhile, sirloin, new york strip, and prime rib steaks—each aged 21 days and char-grilled to order—show the pub's upscale side, while the full bar's bounty of imported and domestic beers settles bets between physicists on how many black holes a pint of Guinness contains.
The Bank Restaurant, which was founded in 2007, draws ingredients from local farms including Elliot and Sons Bison, Catalpa Grove Lamb, and Piper City's T&J Free Range Poultry. The new menu is filled with specialties ranging from center-cut pork chops to thick burgers bracketed by soft brioche buns. Steaks arrive unadorned or tenderly rubbed with the restaurant's precise blend of spices, and seafood including Hawaiian style arctic char and "as seen on TV" seared scallops play well with their respective glazes and dipping sauces.
While the kitchen fills with culinary innovation that earned the restaurant the 2012 and 2013 Gamon Award for Restaurant of the Year, the dining room and surroundings exude vibes of timeless history. Built in 1875 to house the Gary Wheaton Bank, the building counts among its roster of notable visitors people such as football great Red Grange, journalism tycoon Colonel Robert R. McCormick, and the pink hippo from Hungry, Hungry Hippos.
Within Studio Movie Grill's expansive auditoriums, towering screens enrapture audiences seated in plush leather recliners and at dining tables. As the familiar celebrity faces in blockbuster and cult-classic features deliver Oscar-worthy lines, sneakily quiet waiters deliver meals from a full menu decorated with more than 100 items, including gourmet pizzas, smoked ribs, and cocktails infused with the spirit of Daniel Day-Lewis. Bartenders at the lobby bar dole out glasses of premium liquors, wines, and draft beer before and after shows.


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3. Karaoke at The Rickshaw
One thing that never fails to impress a date is whipping out a hidden gem that other dudes don't know about. Here's one from our vaults. Way up in the North End lives the Rickshaw, a Chinese dive bar/karaoke joint that gets hilariously rowdy until 2a. If she's the adventurous type, this is an unbeatable second date.
322 N 105th St, Bitter Lake (206-789-0120)


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Lady Luck
Lil Lady Bug Infant Costume
Ladybugs are said to bring good luck - let your little one be happy go lucky on Halloween in this adorable black, white and red Lil Ladybug infant's costume. It even includes a headband with antennae - so cute! be sure to take pictures to capture the memories.
Itty Bitty Lady Bug Baby Costume
Ladybugs are said to signify luck - get lucky on Halloween when you dress your little one in this cute as a bug's ear Itty Bitty Lady Bug costume. The absolutely adorable costume hasleg snaps for easy diaper changes, a darling hood with antennae and detachable wings, plus slip-on booties with skid…
Ladybug Mini Dress Adult Womens Costume
Have a lucky Halloween in this Ladybug Mini Dress adult womens costume. The red, zippered tube dress features black polka dots and comes complete with a matching headpiece along with sheer dotted wings. Flit, flutter and flirt all night in this sexy womens costume.
Cute as a Bug Girls Child Costume
Touch as many people as you can because you'll be a stroke of luck on Halloween wearing this Cute as a Bug Girls Child Costume. Fly from door to door in black and red polka dot dress, detailed wings, antennae and leggings.


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Select () or exclude () categories to narrow your recipe search.
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"My DH will eat anything but when he says, "Good job, Hon" I know it was a major hit. We both loved this. I doubled the sauce ingredients and added a pinch of cayenne as we like spice. I also sauteed some diced onion and minced garlic at the same time I stir fried the shrimp. I took the suggestion of another reviewer to add some cream cheese and..."
"My husband and I liked this a lot! I am not fond of rice in stuffed green peppers so this was a great find. I did add one third of a can of tomato soup to the meat mixture and poured the remaining two thirds of the soup over the stuffed green peppers. The measurements of the seasonings was perfect. Oh, I did use ground turkey."
"This was a very delicious recipe. I added 2 to 3 ounces of bleu cheese and served with parmesan basil wheat thins. I thi8nk feta would have mixed nicely with the roasted red pepper mix too."
"Excellent! I used 1/2 cup low fat peanut butter, 1/4 cup brown sugar, 4 cups chicken stock rather than 5 vegetable, and one can of fat-free evaporated cream. It turned out wonderful. My DH really enjoyed it and couldn't quite identify the peanut butter taste. To him it tasted like a soup cooked out over an open fire. This is a keeper. Thanks, ..."
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Thank you all for your thoughtful and charitable responses.
To those of you who missed it in the early part of the thread, I did say in response to a post Jerry made that I was not aware CM was intended to be for platonic friendships and fellowship as well as for folks searching for a spouse. I also was not aware that at one time, though Jerry is not sure if it is still the case, divorced Catholics were asked to sign an agreement not to use the site for dating purposes unless their marriage was annulled. Jerry also stated that divorced members are not allowed to use the match feature of the site. I am absolutely sure these safeguards are not intended as a punishment of any sort - or to make a judgement that anyone is bad or has done anything wrong. Like the teachings of the Church, these guidelines must be here to try and help us all remain faithful to the teachings of the Church which is an act of charity, otherwise CM would be supporting, in some way, adultery.
Some of you may have also missed in a early post the statement I made that, since CM is open to those also seeking fellowship or friendship, one could argue that including those who are not in agreement with the teachings of the Church might prove beneficial for all concerned.
From my perspective, from what I've been taught by people I respect VERY much, we're all here on earth with one primary goal - to get to Heaven and to help our brothers and sisters do the same. And I am heartened to hear that a number of you have experienced directly conversions of heart occurring on this site through interactions with others. Praise God!
Also from my perspective - no one has to agree with me of course! - I think it is an excellent opportunity to teach some of the truths of our Faith by providing a link with accurate catechesis about the 7 faith questions - what the Church teaches on each faith question and why - by providing a link directly next to each Faith question. For example, "Do you believe in the real presence of Christ in the Eucharist?" (click here to find out what the Church teaches and why) _____Yes ______No As a few other people suggested there could also be a comment area provided if the person wished to expound on their answer. Talk about opening doors to communication! :-) Not trying to tell CM how to run their site - I think they do a very good job! Just a few suggestions!
God bless you all.
In Christ's Love,


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This stunningly rich wood panel bed features convenient, built-in LED touch-lights.
An exceptional bed that seems fit for royalty, this wood panel bed featured absolutely gorgeous wood work with detailed carved posts at the four corners, beautiful scroll work in the headboard and a wonderfully rich and warm noir finish with distressing and burnishing for a textured, multi-dimensional look.
Our associates are standing by to assist you.


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More information
To learn more about the connection between alcohol and the heart, visit the American Heart Association.
SOURCES: Stephanie Chiuve, M.D., instructor in medicine, division of preventive medicine, Brigham and Women's Hospital, and research associate, Harvard School of Public Health, Boston; Michael Davidson, M.D., director, preventive cardiology, University of Chicago Medical Center; October 2010 Heart Rhythm
Copyright©2010 ScoutNews,LLC. All rights reserved |


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Fall 2003
JPN 320K • Readings in Modern Japanese I
Unique | Days | Time | Location | Instructor |
28165 to 28170 | Multiple Sections |
Course Description
This course will mainly focus on developing reading and writing skills. Reading skills To build up vocabulary and kanji To become familiar with long, complicated sentences To become familiar with Japanese discourse styles To be able to use a kanji and Japanese-English dictionary To be able to rapid-read short essays and stories Writing skills To be able to express your own ideas in Japanese To be able to write simple essays and letters in Japanese To improve your handwriting as well as word processing and emailing skills in Japanese To be a self-directed learner Unfortunately learning a language takes a long time. You have to learn Japanese by yourself sometimes. Always monitor your progress or learning methods. Find out your own most effective and (cost and time) efficient ways to learn Japanese.
Grading Policy
(May vary) Lesson quizzes / Kanji quizzes / Final Exam / Vocabulary quizzes Compositions / Culture Notes quizzes / Homework / E-mailing Group Project - Newspaper Publishing
An Integrated Approach To Intermediate Japanese. 1994 by Akira Miura and Naomi H. McGloin The Japan Times


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King James Version (KJV) | New International Version (NIV) |
25 For he must reign , till he hath put all enemies under his feet. | 25 For he must reign until he has put all his enemies under his feet. |
The King James Version is in the public domain. (The King James Bible Version Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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quote:Fortunately, they arent allowed on Team Sweep.
quote:Good to see you back buddy
quote:I will be the one to say it ALL IN 4 LF
quote:why do people think he is getting suspended for a game or two? I never expected him to miss any game at all.. He just punched someone in the face...
quote:Team Sweep Assemble!!
quote:Team No Ceilngs
quote: I may be ignorant of the law but it just doesn't seem worthy of the court wasting the time of a judge.


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Department Scholarships
The Department of History and Paralegal offers a number of scholarships to majors within the department each year. The application and distribution of the scholarships is run through the Winona State Foundation. The exact application dates vary from year to year, but take place during the spring semester. Awards are granted during the same semester, applicable to the following academic year.
Students wishing to apply need to consult and review the scholarship process.
For questions on the application process, please email the WSU Foundation Scholarship Office at email@example.com.
Description of History and Paralegal Scholarships:
- Frederick A. Jederman Scholarship. Junior and senior history majors with a strong interest in historical research may apply for the Jederman Scholarship established in the memory of Frederick A. Jederman, who taught history at WSU from 1924 to 1964.
- Junior and senior history majors may apply for the Norman and Clare Sobiesk Scholarship, honoring Dr. Norman Sobiesk, who taught history at WSU from 1970 to 2005.
- History and Paralegal majors are eligible for the Marvin and Muriel Palacek Scholarship, honoring Dr. Marvin Palacek, who taught history at WSU from 1964 to 1985.
- History majors are eligible to apply for the Isaac Bera Scholarship, honoring former WSU student Isaac Bera.
- Paralegal majors are eligible to apply for the Henry Memorial Scholarship, honoring Steven R. Henry.
- Paralegal majors are eligible to apply for the Peterson Scholarship given in honor of Judge Duane Peterson and Patte Peterson.
- Paralegal majors are eligible to apply for the Paralegal Alumni Scholarship, established by the Paralegal Alumni.


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I'm trying to find Elizabeth Dollins who married Daniel Royce Moberly in Dallas, Texas area. I believe she was his second wife. His third wife was Catherine Boyer. I know of two children of Daniel Moberly: Hazel b. 1880 and Marion J. b. 1904. Not sure which wife was their mother(s). Thanks, Bettie Tripp Waddle
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bought a six pack dogfish head indian brown ale. It was incredible would love a recipe for that or anything even close. great beer to try.
Midwest makes a Indian Brown recipe that is pretty good. I'm not sure how close it is to DFH, but it's a start.
That recipe is in Calgione's book 'Extreme Brewing'
thanks ill check it out


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America's Coolest Hipster Hotels
Courtesy of Kennedy School
McMenamins Kennedy School, Portland, OR
This unique, scholastic-themed property embodies Portland quirkiness. Housed in converted classrooms—the building was once a neighborhood elementary school—guest rooms feature chalkboards, playful little water fountains, and children's coat hooks. While the TV show Portlandia may have relegated the city's McMenamins hospitality empire into the "over" category, the hotel's on-site microbrewery, art-house cinema, and moody cigar lounge (called the Detention Room) are still beloved hangouts for local hipsters.


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Probably the most infuriating, if entirely predictable, outcome of the Supreme Court's fusillade of 5-4′s this week was the MSM's dewy-eyed credulity that accompanied it. Now, I'm not implying that say, Adam Liptak of the NYT is a clueless ninth grader, but his reporting would have been considerably more respectable if he were. Pretending to parse the hastily concocted legal reasoning du jour behind decisions that were already made twenty years ago by the Court's right wing not only makes boring reading, but it insults the intelligence of anyone capable of tying one's own shoes.
Late Night: Condi's Anthem, SCOTUS Edition |
By: cocktailhag Thursday June 27, 2013 8:00 pm |
It's "Severely Conservative" [Intellectually Challenged] Week! |
By: Scarecrow Monday February 13, 2012 7:04 am |
Pull the cord on your parachutes, people; we're in intellectual free fall this week. After Mitt Romney earned the award for most preposterous political whopper by labeling himself "severely conservative," everyone became severely challenged.


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Receive a $10 mail in rebate, when you purchase a 6-dose package of Trifexis (spinosad + milbemycin oxime) from your veterinarian.
To receive your rebate, mail original dated cash register receipt showing product (s) purchased and completed certificate. See mail in rebate form for more details. Allow 8-12 weeks for delivery.


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40 minutes until Southland and Justified come on, our only weekly tv indulgence. Glad they came up with a DVR! Hopefully Justified will be worthwhile. At least it is in my beloved Kentucky, so it better be!
________________________________________ "I'm your brother, just make it count."
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I watched it. Seems like he has more than one service pistol. Shoots the first guy with a Sig p226. Later, it appears he has a 1911 in his holster. In a scene from the trailer, he has a Glock. I thought it was good with some good characters.
From C3Shooter: Skullcrusher, you are evil, sick, demented, twisted- and my hero!
I liked it, but I was hoping he'd carry a more manly gun.
I liked it okay.
I watched Justified last night. It seemed like it will be OK. I noticed the sidearm changing a lot too. I guess he has one of those secret rooms that opens up to show a huge stash of weapons He's a real quick draw with them all too. Being I lived in Somerset Ky. for years and still live close to there it's kind of cool to see a show that is set in the area. I just hope they don't have him killing a bad guy with that quick draw while jumping a shark


text: HomeMedia BiasCNN 'White Left Winger' Banfield Defends Kwanzaa ©2015 Black & Right January 5, 2013 Media Bias, Race, Society 5 Comments Do you think CNN's Ashleigh Banfield took offense to the "white left winger" label and used her television platform as an excuse to attack Wisconsin State Senator Glenn Grothman who makes legitimate points about Kwanzaa? The "ancient roots" of Kwanzaa, Ashley? Puh-leez. GoodMojo What was it again, that the Senator said that was untrue? White left-wingers… Can't live with them, can't flush them away. Tallyman Poor Dumba Ashley needed to use Bush as her source, while Dumbo Roland used Dumbo Biden's laughter as an intellectual argument. Who in Africa or all around the World celebrates Kwanzaa? Full of emotional sound and fury and signifying no intelligence. A fruit holiday for White fruits and nuts. The Machine Well, incarcerated violent criminals thinkin' up shit does date back to antiquity, no? Igor I don't give a rats ass if Ashleigh's feelings are hurt. Get over it, ya liberal witch with a capital B… Uncle Rick "Left-winger" clearly put a burr under Ashley's saddle. I wanted to hear why Sen. Grothman originally declined the interview with Roland; he indicated that Ashley had distorted his reason, which she seemed eager to prevent us from hearing. Karenga's background is a legitimate subject and very pertinent to this discussion. Is it likely that a violent separatist would create a holiday full of love, harmony and unity? That apparently makes perfect sens to Banfield.


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Are you looking to dress up your front yard for Halloween? There is nothing better than making your own DIY Halloween yard decor. It's much more cost effective and best of all you can customize it to fit your needs, style, and space! I've put together a list of 40 Halloween DIY yard decor ideas. Whether your a beginner or a seasoned professional there are projects for all levels. Zombie Planted Hands from Sew Woodsy Halloween Arch from My Fun Projects Spooky Outdoor Hanging Decoration … [Read more...]
20 Pregnant Halloween Costumes
Looking to make a DIY pregnancy costume? Check out my list of 20 Pregnant Halloween Costumes that are easy to make in just minutes! Last year, while I was 4 months pregnant I scoured the internet for halloween costume ideas while being pregnant. I never got around to sharing this round-up and I wanted to share it this year. Pregnant women have the right to dress up for Halloween too, and what better time to dress up then when you have a cute bump to sport! Here is a list of 20 of the very … [Read more...]
Nine Tips for Reducing Lingering Odors in the Kitchen #HealthierHome
I am a Filtrete Brand blogger ambassador and was compensated for this post, but all opinions and selection of additional products used in this project are my own. Have you ever fried bacon on the stove top for breakfast and smelled it all day and night? If their is one thing we don't like it's lingering odors. We've come up with a list of nine things we do in our home to help combat odors in our home, specifically in the kitchen. Here are nine tips for reducing lingering odors in the … [Read more...]
15 Nursing Cover Tutorials
Before the baby was born I was busy sewing up some projects. I'm glad I sewed when I had the chance because I still have a few projects I want to get too, but I think they will be waiting for a few more weeks. One project that came to mind was a nursing cover. The big box stores charge on average $30 for a nursing cover. I think I made mine for under $10 and even better I got to choose the fabric I wanted! Since there are already tons of fabulous tutorials out on the web already, I really didn't … [Read more...]
DIY Mother's Day Craft Ideas Round-Up
I'm so excited to have my friend Claire, from A Little CLAIREification here today. We met last year at our local blog conference and chat frequently in our Central Florida DIY Bloggers Group. I'm so happy we finally have DIY bloggers where we live! She is sharing a great round-up of mother's day gifts to make today! ------------------------- Hi there Sew Woodsy readers! It's me, Claire, from A Little CLAIREification and I am so thrilled to be sharing here today while Katie is taking some … [Read more...]
25 Handmade Gift Ideas
Today, Lauren from The Thinking Closet is here to share her round-up of 25 Handmade Gift Ideas! Lauren is a fellow CFL blogger. We worked on the children's home office volunteer project together, attended Haven (see photo below), and attended CFL Blog Con together. Plus we chat via email, text, and Facebook! I'm super greatful she is here today to share her round-up of 25 Handmade Gift Ideas! --------------------------- Greetings Sew Woodsy fans! My name is Lauren, and I am tha-rilled to … [Read more...]
Up-Cycle Furniture Round-Up From My Repurposed Life
Today, we have our sweet friend Gail, from My Repurposed Life sharing some pretty darn amazing up-cycles. If you're not familiar with Gail's blog you need to go check it out asap. She is all about transforming thrift store finds into amazing new pieces! We met Gail 2 years ago at Haven and have stayed in touch with her since then. We typically chat via email and every time we see her its like we picked up where we last left off! We can't wait to see Gail in a few short months at Haven and … [Read more...]
Easter Craft Ideas
Today we have two lovely ladies that are near and dear to my heart; Bonnie and Trish from the blog, Uncommon Designs. I absolutely adore their blog and adore them. Today they are sharing some super cute (and easy) Easter Craft Ideas! ------------------- Hey y'all! We are Bonnie and Trish and you can find us at our blog, Uncommon Designs. We just adore Katie and are so happy to be here while she is enjoying some time with that sweet baby of hers. At Uncommon Designs, we blog about all … [Read more...]
Crafty and Creative Favorites From Simply Kelly Designs
First off, a little update. If you follow along on social media you know that the baby has not arrived yet. He is being stubborn! Hopefully, he will be here in the next few days. Today, my dear friend (in real life) Kelly from Simply Kelly Designs is sharing a few of her crafty and creative favorites. Kelly and I met a few years ago at a friends bunko night. We hit it off immediately and when I found out she was crafty and had a scrapbooking blog I knew we were a match made in heaven. Kelly … [Read more...]
10 Spring Projects from Homework
Today, I'm so excited to kick off a month full of guest post. Still no baby yet, but this in an effort so once he is here we can devote and spend some time with our baby! Our first guest is Carolyn from homework. She is sharing her top 10 spring projects. I've known Carolyn a few years now and she has guest blogged for us before. She made the most adorable pom pom snowman ornaments for the first ever 12 days of Handmade ornaments. Last week, was the official first day of spring, Carolyn … [Read more...]


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Date of the Event:
Friday, July 12, 2013 - 7:30pm On July 12th at 7:30pm, the Metaquizzical cafe at Lydia's Sunflower Center in Petaluma will present "a tribute to the moon and other heavenly bodies." Jim and Kathy ocean will serve up their unique blend of 'thought rock' for those seeking fresh lyrical commentary. Lydia's sunflower center is located at 1435 north Mcdowell boulevard. Suite 100. for details call Kathy ocean at (707) 869-9403.


text: I think this museum has been limited by the lack of space, a lot has been squeezed in, which leaves it a little disjointed. That said it is free and try's to present as much as possible of the history of the now gone Hampshire Regiment which is commendable. I would suggest it is visited as part of Winchester Military... More


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Nintendo Land is a fun and lively theme park filled with 12 different attractions, each with its own take on a Nintendo franchise. Each attraction features unique and innovative game-play experiences made possible by the Wii U GamePad controller. Depending on the attraction, players can compete solo or against other players, or even team up to play cooperatively. Up to five players can participate in dynamic multiplayer modes in select attractions. The experiences change every time, depending on whether players are using the GamePad, holding a Wii Remote or just watching others play on the TV screen.
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Lexham English Bible (LEB) | New International Version (NIV) |
29 {Otherwise} [after] he has laid the foundation and is not able to finish [it], all who see [it] will begin to ridicule him, | 29 For if he lays the foundation and is not able to finish it, everyone who sees it will ridicule him, |
Scripture quotations marked (LEB) are from the Lexham English Bible. Copyright 2012 Logos Bible Software. Lexham is a registered trademark of Logos Bible Software. (Lexham English Bible) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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Thanks to the generous sponsorship of Arc'teryx, the AMGA is bringing the Round Table Discussion on Advocacy to you. This is a great opportunity for members to connect with AMGA staff, hear about our recent initiatives and advocacy efforts, and discuss national and local guiding issues.
September 12, Friday, Seattle WA.
• Venue: Mountaineers Seattle Program Center, Goodman Rm., 7700 Sand Point Way NE, 98115.
• Time: 5-8pm PDT
A HUGE THANKS TO THE MOUNTAINEERS FOR SUPPORTING and HELPING ORGANIZE THIS IMPORTANT EVENT!!!
SPECIAL UPDATE FOR SEATTLE ROUND TABLE: The AMGA is excited to host, in partnership with Arc'teryx, the 3rd stop of our Round Table Tour on Advocacy at The Mountaineers in Seattle, Washington. This meeting will be unique in that stakeholders from all facets of the guiding/outdoor industry will be present to engage in a broader discussion about the U.S. permitting process and the common challenges we all face as commercial operators on our public lands. The goal of this distinctive round table discussion is to identify the common challenges of guides, guide services, outdoor educators, and volunteer groups etc. as it relates to accessing/utilizing our public lands and to begin building a conversation that focuses on creating a unified voice for advancing the greater needs of the outdoor recreation service provider.
We invite you to be a part of this very important dialogue. Light food and beverage will be
provided. We look forward to seeing you there!
December 3, Wednesday, North Conway NH.
• Venue: Eastern Mountain Sports Climbing School, 1498 White Mountain Hwy. 03860
• Time: 5-9pm EST
Topics of Discussion:
• Permitting Process on U.S. Public Lands
• Needs of AMGA Stakeholders
• Common Challenges & Opportunities
• Strategies for Moving Towards Improved Access
BE A PART OF THE CONVERSATION and COME TO A ROUND TABLE DISCUSSION NEAR YOU!