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It's so easy to teach with tunnel vision. To go into your classroom, see your students, and do what you feel is best. You, the kids, and the learning. I honestly think there was a time when I taught with tunnel vision. I went to school, college, collected degrees, and thought I knew best. After all, my business card said "Teacher" and I was led to believe that that title made me the expert in the room. But, then I realized something. There is value in not knowing everything. There is even more value in openly admitting you don't know everything. But the most value? It's in being open to learning from others. Right now, there is another teacher somewhere that can benefit from what you have to share. And right now? There's another teacher somewhere that can teach you something. There's a kid you can learn from. There's a colleague who can make a statement to challenge your thinking. We are so uncomfortable being uncomfortable. We crave to know the answers and be the expert. But the magic? It happens when we learn, from each other. From the teacher next door, the teacher in another building, the teacher in another country. Inspiration is everywhere. We just have to keep our eyes and ears open.
Want Venspired In Your Inbox?
Hi, I'm Krissy Venosdale. This website is my little corner of the internet where I share my passion for teaching and learning. Named because I'm inspired by the people I connect with and the kids I've learned from, Venosdale + Inspired = Venspired. I've taught gifted education for 11 years where I developed my love of technology integration, STEAM, PBL, and authentic learning. The world is an awesome place, and we just need to connect kids to it with enthusiasm. I'm a forever learning, connected collaborating, Sharpie collecting, poster making, eternal optimist. I still wish on stars and consider creativity one of life's basic needs... just like breathing.


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Before (left) and after (right) the Confederate shell exploded. |
A better version of the photograph on the left before the shell exploded. The smoke coming from a fire in the shelter built into the canal in the background is obviously different from the smoke said to be coming from the exploding Confederate shell. |
Animated stereoview that looks like it was taken during the same photo shoot as the other two photographs. |
Source 1.
Source 2.
Source 3.

subset: commoncrawl


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1. Origin of Screen name? I love the ghost host so i though ghost hostess would be cool
2. Real first name?Tori
3. State, Country?UsA
4. Number of times you've been to Disney?DL=7 WDW=0
5. Favorite ride?Haunted mansion, the tiki room, pirates, jungle cruise
6. Favorite park?disneyland/MK
7. Spouse? Sig Other? # kids?... no children no spouse
8. Pets? My dog daisy, a ferret named critter
9. Occupation?.... disneyland/WDW addict
10. How you found DWT.com? the pod cast
11. Intereasting facts about yourself..? i love disneyland! i am hopefully going to WDW in september...
ummmmmmmm I speak whale


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- 63Promote
Art Print
Collect your choice of gallery quality Giclée, or fine art prints custom trimmed by hand in a variety of sizes with a white border for framing.
Really wonderful!~ You can totally tell that this took time and care to make, and it makes it even more fab knowing that! :D
Thank you, Ebi! Yup, I put together several months' worth of collected textures, actual physical discards (broken old roof slats to make the forest floor), 3-inch nails for trees, and lots more.
All made from bits of garbage: old roof slats, rusty nails, pens with blunted nibs... I had a lot of fun assembling this.
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| Email | Full Article (TrendHunter.com/id/134164) |
A rooftop helicopter landing doesn't sound like the most glamorous setting for a fashion photoshoot, but after catching the Magdalena Chachlica 'Stop & Look!' shots, you might be rethinking that assessment.
Lensed by photographer Numpo, the shoot captures the collaboration of talents by Fashion Color's model Magdalena, stylist Justin Ziarko, and sleek hair and makeup by King Zawila-Szeliga. Making good use of color blocking, Ziarko outfits Magdalena in an array of simple yet sophisticated pieces, complimented perfectly by dark smokey eyes and red lips. In photos that are more about the artistic composition than the fashion, Magdalena plays her part perfectly, leaving just enough room for the viewer to admire the gorgeous blue sky behind her.
For a look at sleek fall and winter fashion and a quick lesson in photography, don't miss the gorgeous Magdalena Chachlica 'Stop & Look!' story by Numpo.


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insert between pages 13 and 14 of regular story
Includes letters from David R. Wood, David Dark, Kevin Eldridge, Todd Goodman, Eric Young, David Pulleyblank, T.M. Maple, Them Bones, Robert T. Sumner and Dale Coe.
Includes a checklist of other DC titles on sale the week of June 20th, 1985.


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Reviewed Eggplant Parmesan Meatloaf
Sep 23, 2013 in Food Network Community Toolbox on FoodNetwork.com
"My husband watched this show and wanted to try this recipe. We loved it! This is the best meatloaf recipe we have ever made, not too mushy or too dry, it was perfect. We felt like we were eating a gourmet meal. We accompanied our meatloaf with roasted potato wedges and grilled zucchini with a rustic peach and raspberry tart for dessert. As for ""


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Nissan Pathfinder Bent Hatch
Posts: 1
I opened the back hatch of my pathfinder after an ice storm. apparently there was a thin layer of ice on the top. The hatch opened fine until I heard a crunch when fully opened. Now I have a 4 inch bend in the top of the hatch. The hatch and the roof of the pathfinder no longer match up. Is this a design flaw? Why did the hatch bend so much and so easily due to a thin layer of ice.
Has anyone else had similar experiences?
Any suggestions?
Has anyone else had similar experiences?
Any suggestions?
elproducto42 Posts: 5
This discussion has been closed.


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"best snack ever...I put it in a big tupperware bowl to keep in the pantry and the kids LOVE it!! also great when the rice and corn chex go on sale and I can match coupons :)"
"made great 'breakfast burritos' for dinner!! MY whole family loved it and it was super easy. even took the leftovers (there was alot!) on vacation w/us for quick and easy breakfast!! thanks so much! great w/ a simple fruit salad!"
"Sooo delicious! I definately needed to add the pepper flakes and I used 1/2 c. light sour cream instead of the milk powder. I too increased the turkey to 1 lb and next time will use 4 c. noodles instead of just 3 to make a perfect 9x13 dish. I diddn't have garlic so I substituted Tastefully Simple's "Garlic Garlic" instead. My family loved it!"


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Last year I had cucumber and cantalope/melon vines continually wilt just as they were getting really productive. This happened over and over. Someone on one of the forums here recommended I try spraying with permethrin starting when the plants are set out, then stopping once they bloom. I have tried this although it did take me a couple weeks to find permethrin so the first several weeks my plants did not get sprayed.
I'm still losing one cucumber after another to wilt. I even tried covering some younger starts with insect cover and when I pulled it back there were the cucumber beetles under it! I have now also lost two of my muskmelon vines before they ever set fruit. I was spraying the permethrin once/week. Do I just need to give up on growing muskmelons? how do other people deal with this? I do scout my garden daily and squash every cucumber beetle I can find. They are fast unless I get them early in the morning. Thanks for any advice. |
Follow-Up Postings:
Permethrin is a synthetic form of an insecticide made from the roots of certain chrysanthemums, pyrethrins, and appears to not only be very broad spectrum but very persistant in the environment. Using a broad spectrum insecticide means that you will also be killing off any predators of the insect pests you have which then means the pest will return sooner and in larger numbers. Controlling Cucumber Beetles, Squash Bugs, Squash Vine Borers is the same and requires multiple methods, starting with your soil. The link below may be of some help. |
Here is a link that might be useful: Cucumber beetle control
Thanks, I really did hate to use the permethrin, after all the whole reason I am growing my own food is so that it will be healthier for my children. But the person here who recommended it seemed like he really knew what he was talking about and I am feeling desperate since despite picking off every beetle I can catch my vines wilt just before the fruit ripens. Very frustrating. That link was to the squash bug page but I found the cucumber beetle page. Most of what they recommend I am already doing but I will plan to try trap crops (which will take up alot of garden space I'd rather use for something I'm actually going to eat) and encouraging bats next year. Other than that there didn't seem to be a whole lot I could do. I have tried row cover, as I said. thanks for the advice |
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Chatting With Food Network Star's Susie Fogelson
by Maria Russo in Interviews, Judges, May 9, 2013For years on Food Network Star you've seen Bob Tuschman and Susie Fogelson guide, grow and, ultimately, judge and eliminate dozens of Star hopefuls, but how much do you know about these face of Food Network executives? Just in time for next month's all-new Star premiere, on Sunday, June 2 at 9pm/8c, FN Dish chatted with both Bob and Susie to learn a bit more about their roles at Food Network, their experiences in the kitchen, plus their thoughts on past seasons of competition and what makes an ideal Star candidate. Read on below to get the inside television scoop from Susie, senior vice president, marketing, creative services & brand strategy, then read an exclusive interview with Bob.
Tell us a bit about what you do. What does a typical day look like for you?
Susie: Busy! I have the best team in the business, but it takes a lot of meetings, brainstorming and work sessions to keep this ship sailing. We're all pretty much nonstop from the minute we get into the office, but we also all manage to have a good work/life balance, which is the most important thing.
Working at Food Network must mean you're surrounded by food all day, or at least thinking about it. Do you like to cook at home?
SF: Yes, my family recently moved to a new apartment in Brooklyn with a lovely, open kitchen, and we use dinnertime as family time. Cooking is a great relaxing way to unwind at the end of the day, have some fun with my kids and do something healthy for my family.
What's your favorite type of cuisine, whether to cook or eat out?
SF: I'm from Los Angeles, and you just can't beat the delicious authentic Mexican food I grew up eating as a kid. As a result, I'm a sucker for fresh, crunchy flavors like tortillas, salads, fish tacos and anything in a wrap.
Do you have a favorite Food Network recipe?
SF: Anything by Giada — my family loves her recipes.
What was your most-memorable meal? What, where, with who — details, please!
SF: My husband and I love Blue Ribbon in Brooklyn; they have amazing Kumamoto oysters that they shuck right in the front of the restaurant. We like to sit at the bar, have oysters and sip on their delicious ginger martinis. It's the perfect night out!
This is the ninth season of Food Network Star. Has it gotten easier for you to tell who the most-promising contenders from day one are?
SF: I think so, yes. You can usually spot that glimmer in someone's eyes that indicates they've got something special, some wildly creative or unique perspective that makes them stand out. But you also have to keep in mind that some people are like fine wine and they need time to ripen. Those are the folks that can surprise you, and it's worth being open-minded and patient and wait for them to reveal themselves during the process.
What's one of the most important things you've learned from past seasons of the show that you carried with you into this upcoming season?
SF: That you need to have an open mind because there are so many different ways to partner with talent and so many avenues to pursue. Oddly enough, I find that someone with a very distinct and strong point of view is often the person that reaches the most audiences. In this fragmented media landscape, a specific point of view is really attractive and important.
Has there ever been an instance when you and Bob have felt one away about a particular finalist, but the other judges — Alton Brown, Bobby Flay and Giada De Laurentiis — felt differently? How was it resolved?
SF: Of course. It happens every season! It's just not normal for five people to agree on everything, and I think that's one of the things that makes the show feel interesting and real. There's no one way to resolve a disagreement — usually it comes down to everyone passionately pleading their case until we come up with a resolution that feels right. There's a bit of lawyering involved.
Fill in the blanks: A Food Network star must be ________, must enjoy ________ and must be able to ________.
SF: Must be one of a kind and effusive, must enjoy food and people, and must be able to be consistent yet creative.
Related Reading:
Similar Posts
Luca Looks Back on a Wild Ride
Italian-born Luca Della Casa came into the competition with his heritage as a point of view, and while his culinary offerings were strong, he struggle...Comments (
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[...] For years on Food Network Star you've seen Bob Tuschman and Susie Fogelson guide, grow and, ultimately, judge and eliminate dozens of Star hopefuls, but how much do you know about these face of Food Network executives? Just in time for next month's all-new Star premiere, on Sunday, June 2 at 9pm/8c, FN Dish chatted with both Bob and Susie to learn a bit more about their roles at Food Network, their experiences in the kitchen, plus their thoughts on past seasons of competition and what makes an ideal Star candidate. Read on below to get the inside television scoop from Bob, senior vice president/general manager of Food Network, then read an exclusive interview with Susie. [...]
The Positives:
Effusive is a good quality in a Star.
It's also nice when we watch a contender and clearly see that twinkle or when we get that obvious feeling that He or She has--got it! I agree.
It's also a positive thing on the judges part to be open-minded enough to realize that some cooks bloom like a flower. This is a good thing, too. We have been surprised in past seasons. We have also seen people who were strong right out of the gate and consistent.
A concern I do have:
While it is good to have a point of view, specialty, or focus is that it rapidly becomes an iron straight-jacket and that as soon as a cook dares to go beyond their specialty or show some range of skill, they are pounced on about not being true to their roots or point of view. Sadly, we've seen this happen in past seasons. Consider this: Who is a better carpenter, someone who is very skilled at putting in a window (but that's about it) or someone who can expertly lay a floor, put on a roof, do wiring, and make custom kitchen cabinets? The one who can do-it-all and do it superbly wins! Why should cooking be any different? For example:Who says a Mexican cook cant also make top-notch desserts. Please don't let point-of-view become a confining prison. -
[...] FN Dish – Food Network Blog [...]
Will there be coaching this year?
last year, Bobby, Giada and Alton all coached and gave 1-on-1 advice to the people on their teams. I was glad to see that. But whether there will be or wont be this year, in the spirit of: there's-more-than-one-way-to-skin-a-cat, or cook a great meal, I really hope the judges will let the competitors be themselves. By that, I mean: if someone makes an Italian dish any different from how Giada might fix it, or a southwest dish any different from how Bobby would have done it, that it isn't automatically "wrong." As long as it tastes great, who cares? After all, I'm sure Giada does her own thing and its still wonderful, even if her Mom woulda done it differently. Something to think about. -
Hurray! The Videos are up. See who's who.
Thank you Food Network. http://www.foodnetwork.com/the-next-food-network-... -
Looking forward to it. Literallllllly have grown up with this show. and have seen changes. Some good some bad.
I didn't like the pitch room. They can leave that out this time.
Please please please why don't these execs have the women pull their hair back. It's all flying around in the food. Every food show is guilty of this.. Where are bob and Susie on this?
I see Susie, who didn't personally care for last season's Emily Ellyn , took note of the viewers feedback, and cast Stacy in the ROLE of Emily Ellyn for this seasons show. Really? Stacy says her POV is taking vintage and making it Modern. Hmm Where did we hear that before- Retro Rad maybe? Is Stacy's POV authentic, or scripted?
How would someone make vintage modern?
I am sad to see FN stoop to the level of other reality shows by keeping Danushka, who by the way, was in the bottom 3 for 2 weeks. You will never admit you are keeping her for the drama affect. But judging by comments elsewhere you have insulted your fan bases' integrity by thinking we would want to watch a show hosted by the likes of her. She has no personality whatsoever and is as boring as a rock! I have been a fan on FN for 20+ years, but have lost alot of respect....very disappointed!! As a footnote, I saw her the first time when she was on chopped and couldnt stand her narcissistic, stuck up demeanor then either!


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Traditional Chinese massage
I offer Chinese deep tissue massage , is good for relief back pain,shoulder pain ,legs pain and body pain . When after long day work or come back from gym ,is good to come here, for relax your mind and relief muscle pain. My shop is nice and clean, w


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The Venus flytrap (also Venus's flytrap or Venus' flytrap), Dionaea muscipula, is a carnivorous plant native to subtropical wetlands on the East Coast of the United States. It catches its prey—chiefly insects and arachnids— with a trapping structure formed by the terminal portion of each of the plant's leaves and is triggered by tiny hairs on their inner surfaces. When an insect or spider crawling along the leaves contacts a hair, the trap closes if a different hair is contacted within twenty seconds of the first strike. The requirement of redundant triggering in this mechanism serves as a safeguard against a waste of energy in trapping objects with no nutritional value.
Dionaea is a monotypic genus closely related to the waterwheel plant and sundews, all of which belong to the family Droseraceae.
A software bug is an error, flaw, failure, or fault in a computer program or system that produces an incorrect or unexpected result, or causes it to behave in unintended ways. Most bugs arise from mistakes and errors made by people in either a program's source code or its design, or in frameworks and operating systems used by such programs, and a few are caused by compilers producing incorrect code. A program that contains a large number of bugs, and/or bugs that seriously interfere with its functionality, is said to be buggy. Reports detailing bugs in a program are commonly known as bug reports, defect reports, fault reports, problem reports, trouble reports, change requests, and so forth.
Bugs trigger errors that can in turn have a wide variety of ripple effects, with varying levels of inconvenience to the user of the program. Some bugs have only a subtle effect on the program's functionality, and may thus lie undetected for a long time. More serious bugs may cause the program to crash or freeze. Others qualify as security bugs and might for example enable a malicious user to bypass access controls in order to obtain unauthorized privileges.
The Golden Age of Comic Books was a period in the history of American comic books, generally thought of as lasting from the late 1930s until the late 1940s or early 1950s. During this time, modern comic books were first published and enjoyed a surge of popularity; the archetype of the superhero was created and defined; and many of the most famous superheroes debuted, among them Superman, Batman, Captain America, Wonder Woman, and Captain Marvel.
Publishing of comic books became a major industry. The period also saw the emergence of the comic book as a mainstream art form, and the defining of the medium's artistic vocabulary and creative conventions by its first generation of writers, artists, and editors.
Carnivorous plants are plants that derive some or most of their nutrients (but not energy) from trapping and consuming animals or protozoans, typically insects and other arthropods. Carnivorous plants have adapted to grow in places where the soil is thin or poor in nutrients, especially nitrogen, such as acidic bogs and rock outcroppings. Charles Darwin wrote Insectivorous Plants, the first well-known treatise on carnivorous plants, in 1875.
True carnivory is thought to have evolved independently six times in five different orders of flowering plants, and these are now represented by more than a dozen genera. These include about 630 species that attract and trap prey, produce digestive enzymes, and absorb the resulting available nutrients. Additionally, over 300 protocarnivorous plant species in several genera show some but not all these characteristics.
Me Eat Meat, by John Ostrander
The Problems with Jainism
How Much Is Enough?
It's a trap! The Australian sundew plant that uses tentacles to catapult flies to their death
Beyoncé: I Was Really Nervous About Releasing New Album


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The Enchanted Cave 2
Delve into a strange cave with a seemingly endless supply of treasure, strategically choos
4.32 / 5.00 30,171 ViewsGhostbusters B.I.P.
COMPLETE edition of the interactive "choose next panel" comic
4.06 / 5.00 9,232 ViewsLog in to save your medals! Don't have an account? Create one for free!
This game is our love letter to the greatest movie ever made.
Please go see "The Room" by Tommy Wiseau. It will change you forever.
Press "f" during play for FullScreen mode.
WARNING, don't read this if you don't want help or spoilers.
To record everything, buy the recorder and place it on the living room phone.
To cool off, stand near the fridge and open the freezer door.
the music is from Blackbeatz513 Oo?!
Faqqin nice man ;)
PS: Game is A.W.E.S.O.M.E
That wakeup scene scares me
God there is a lot of talking in this game x.x
While I've never seen this movie, I don't think I want to; as GoofyGoober2 said "must have been a dumb movie"... yeaah >_> pretty much.
Also... why is the autosave screeen so damn creepy?
"Great job! Wow, its really Great Job!" - Tommy W.
This is such an incredible game, The music is amazing I love the hole 8-Bit Style of the its splendor and how you can interact with all of the buildings and people and how it captures some of the worst dialogue in movie history. I really really enjoyed this game, although I don't have the time to review it completely right now I thought it deserved a quick mention from myself and since I don't have the time to really play it full force I have sent this to all of my friends who are fans of the room and they are giving this game nothing but praise and love only playing it within' such a short time. Mr. Fulp you've created another master piece and we thank you.
when i first started playing this i thought it would be like some other games on here, shallow and no fun. but then the story got interesting, i wanted to see what happened next. this is what makes a game good, to catch the player's attention with an alluring story and to make them want to play it till the end. 10/10, 5/5. bravo guys! very well put together!


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Most Popular in:
New in Moisturizers (page 30 of 45)
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Elina Skin Care C-Skin Repair Lotion is a light lotion that contains healing ingredients including rose hips and seabuckhorn oil to hydrate and nourish all skin types. 877-384-8300, www.elinaskincare.com
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Between 1899 and 1962, physics was taught under the label "physical sciences." Classes were taught in the Peter White Hall of Science (pictured right), which was remodeled in the 1950s. By the early '60s, it was obvious that a new facility was needed and the West Science Building was constructed and opened in 1966.
The physics faculty has remained around five members since the 1960s. The introduction of computer courses, which occurred during the mid-1970s, was a significant change for the department. In 1972, a Sprinkle telescope was donated to the university and an observatory was placed in operation three years later. The addition of an astronomy class had drawn non-majors to lectures of 50-80 students. One change that has occurred in recent years is the shift from lecture-style courses to lab courses.
The Physics Department offers courses for majors and minors in other curricula: engineering, allied health sciences, biology, chemistry and education. It also offers courses that meet the natural sciences/mathematics liberal studies requirements.
Source: Pages 318-19 of A Sense of Time by Russell Magnaghi.


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Curt Byrum
Curt Byrum is a member of Golf Channel's live tournaments broadcast team, handling analyst duties for the network's coverage of the PGA TOUR and Champions Tour. Prior to joining the network in 2001, Byrum competed for more than 15 years on the PGA TOUR, accumulating 19 top-10 finishes, highlighted by winning the 1989 Hardee's Classic. His younger brother, Tom, also won the same year at the Kemper Open on the PGA TOUR. As a member of the Nike Tour (now the Nationwide Tour) he earned 18 top-10 finishes, featuring two victories: The 1999 South Florida Classic and the 1993 White Rose Classic. An All-American at the University of New Mexico, Byrum also will compete in select Champions Tour events in 2011.


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Tue, May 20, 08 at 15:34
I make Porcelain jewelry in many designs including dog breeds, cats, leaf and hosta pins and earrings, zoo animals, flamingos, loons, parrots, bone and paw print earrings and more. I'm looking for particular hosta including: Earth Angel, Cracker Crumbs, X rated, Templar Gold, Winsome, Medusa, Surprised by Joy, Ice Age Trail, Cherish, Faith, Hacksaw, Sunlight Child, Dragontails, Teeny Weeny Bikini, Frosted Mouse Ears, Corkscrew, Electocution, Fandance, Gypsy Rose, Hankey Panky, Indian Feather, May, Orange Marmelade, Queen of the Sea, Bridegroom, Rainforest Surprise, Solar Flare, Titanic, Tokudama Flavocircinalis,and Twilight Time. |
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Aug 15, 2014 7:29 AM by Lindsay MacLeod, KSBY News
Scientists say a newly developed vaccine may protect people against the Chikungunya virus.
The mosquito-borne illness, which causes severe joint pain, headache, and fever, has spread to the United States over the past year.
In a study, 23 healthy volunteers were given different dosages of the vaccine over a 20-week span.
All of them built up antibodies to the Chikungunya virus for at least 11 months after the final vaccination, including those who got the lowest dose.
Offensive or inappropriate comments are subject to removal. To report a comment, please e-mail us at email@example.com, and include the name of the story and information on the comment.
Thank you! KSBY.com
13 minutes ago


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Two couples are suing in federal court to overturn the gay marriage ban in Texas, while two others are taking to the state's Supreme Court for the state to grant them a divorce. Between the four cases, the ban on gay marriage in Texas could meet its end.
After eight years of lobbying, the Texas Federation of Animal Care Societies finally got the law in effect.
First the boy made the man—then the man re-made the boy.
Fred Thomas was young, poor, and black. Not only was he afflicted with the terror of schizophrenia, he was also faced with the chaos of the Texas mental health system.


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I bought a Cyclamen from homedepot some weeks ago, it's fading now, most of leaves become yellow, is it normal? I lived in Ontario, Canada. peter |
Follow-Up Postings:
It might be normal... Do you water it a lot? They're not into lots of water and they really don't like being left with 'wet feet'. Damp and free-draining is good. Has it been in a very warm place? Very sunny windowsill. Hot porch. It will have got the message that summer's coming and it's time to go dormant. It might need to 'reset' its growing system because they are often getting ready to come into leaf now. Let it rest until about the end of September, then repot in fresh compost and leave the top of the corm uncovered. Water once and not again until it puts out new leaves. When it has new leaves you can feed it each week. Some say it should not be watered from the top to avoid rot and mildew. More important than that is to ensure the plant is not bunched up in its pot - and air can easily move through the leaves. (Not draughts. Just fresh air.) Allow about 2cm clear all round. Use a half-pot if you have one available. There's less mix to stay soggy. The roots are more likely to fill the mix and use the water/food you're giving it. Keep an eye open for any little cormlets while you repot. It does happen. Keep it in a cool (9-12C) and well-lit place once it gets growing again. However. Ignore all that if, when you gently press the corm, your finger goes through into mush. That's the end. |
vetivert8 - I hope laopi appreciates that s/he has just received about the most sensible, lucid account of how to look after a cyclamen that I have ever read. You answers are always beautifully written and informative. Thanks. (I'm off to the rugby now, 1st home match of the season. Autumn is on its way.) |
thanks, I'll give it a try. |
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From Wikipedia, the free encyclopedia - View original article
Jess Walton | |
Born | Grand Rapids, Michigan, U.S. | February 18, 1949
Occupation | actress |
Years active | 1970 - present |
Spouse(s) | John James (1980-present;2 children) |
This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. (January 2010) |
Jess Walton | |
Born | Grand Rapids, Michigan, U.S. | February 18, 1949
Occupation | actress |
Years active | 1970 - present |
Spouse(s) | John James (1980-present;2 children) |
Jess Walton (born February 18, 1949, Grand Rapids, Michigan) is an American actress, best known for her role as Jill Foster Abbott Fenmore on the American soap opera, The Young and the Restless.
Born in Grand Rapids, Michigan, she attended the prestigious Loretto Abbey Catholic Secondary School in Toronto.[citation needed] Walton left home at the age of 17 and joined a Toronto theater company. In 1969, aged 20, she moved to Hollywood.
Walton briefly dated one of the managers for Joni Mitchell and Crosby, Stills, Nash & Young, and for a time, she associated with them and other musicians, including Laura Nyro and Neil Young. In an interview, Walton recalled a memorable occasion where Nyro taught Walton and Mitchell how to belly dance. Walton says that one of the houses featured on Joni Mitchell's Ladies of the Canyon cover belonged to her.[1]
In the 1970s, after signing with Universal Studios, she guest-starred on Kojak as the ex-heroin addict widow of a TV investigative journalist masquerading as a high-priced call girl. She also appeared on Gunsmoke, The F.B.I., Cannon, The Rockford Files and in the motorcycle movie The Peace Killers.
Walton portrayed the role of Kelly Harper on the soap opera Capitol, from 1984 until the show was cancelled in 1987.
Walton is perhaps best known for her portrayal of Jill Foster Abbott on the soap opera The Young and the Restless. She assumed the role in 1987, after prior portrayer Brenda Dickson left after an acrimonious fallout with producers. She is the fourth actress to play the part on a contract basis. Walton has been lauded for her portrayal of Jill, and is the only actress to win a Daytime Emmy Award for her work as Jill Foster Abbott. To date Walton has won two Daytime Emmy Awards for her work on The Young and the Restless.
Walton is married to John James, an author and founder of The Grief Recovery Institute. In an interview, Walton stated that "[B]efore [John James], I had always gone for bohemian, rock and roll types. John didn't fit the image; he was straighter." The couple have a son, Cole (b. 1981) and daughter, Allison and reside in Oregon.


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VueMinder Lite USB review
VueMinder Lite USB is a free calendar program that doesn't require installation. It looks good and offers all the features you'd want to stay organized and on time.
You'll have to extract VueMinder Lite USB's executable file from the ZIP file it comes in. When you first open it, you'll be prompted to upgrade to the Pro version, but you can opt out of that. Then just click the tiny calendar icon in your taskbar to view your calendar. The interface is polished and professional, with a standard File menu and toolbar at the top … Read more


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Erik Lamela Transfer: Tottenham's £93.2m Summer Signings (PICTURES)
Tottenham have taken their spending for the summer up to £93.2 million with the signing of Erik Lamela from Roma.
The 21-year-old is the sixth new arrival at White Hart Lane and the second on Friday after Vlad Chiriches was unveiled.
Here are the six newbies in Lilywhite...


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You know the old saying, right? First they say that you're a Communist and a thug. Then they reluctantly OK a national holiday in your name, Then they claim you were really one of them. OK, actually that's not an old saying at all -- but it's been irritating in recent years to see folks who -- a) had they been around in 1965 and b) had there been an infrastructure of Fox News, right-wing radio, and blogs -- would have been denouncing Dr. Martin Luther King as a common criminal 50 years ago now holding him up as a hero -- and insisting he was really just like them!
You can trace this back to (who else?) Ronald Reagan. Although let's give the Gipper a small dollop of credit -- he did sign the national holiday for King into law, after all -- he turned around and insisted that the activist's most-repeated line about judging by the content of character meant that he opposed affirmative action (he didn't). Soon the likes of Rush Limbaugh and Glenn Beck were piling on, claiming that the most important thing about King was that he opposed gay marriage (although arguably his closest adviser was gay) or abortion or that he wanted religion in America's public square. They even put up billboards claiming that King was a Republican (he wasn't). This fact-addled fog could almost make one forget the bus boycott, the fire hoses, or the Edmund Pettus Bridge.
But in the end, the far right's misappropriation of the MLK legacy is just comic relief. More insidious, in my opinion, are the moderate folks, many of them well-meaning, who confuse sainthood with sanitation, who want to make a man of peaceful, radical change into a man of peace -- and keep the change. Some of this is Monday morning quarterbacking from folks who would have been afraid of backing -- or maybe would have even opposed -- King's crusades for integration, voting rights, and later to end war and poverty.
Like Jack White, occasionally I have interesting side projects. Over the last couple of years, I've had the opportunity to help one of the nation's leading environmental attorneys -- Stuart Smith of New Orleans -- bring his story to life, and he has quite a story to tell. His book -- Crude Justice: How I Fought Big Oil and Won, and What You Should Know About the New Environmental Attack on America -- is out this week, and it's a great tome to kick back and kick off your 2015.
It's really two books for the price of one. At heart, it's a legal thriller. The first half of the book is a different type of southern-fried True Detective -- call it True Environmental Detective. Stuart tells the story of how, as a young lawyer, he was hired by two machine-shop operators from the backwoods of Mississippi -- whose land had been poisoned by radioactive pipes shipped there by Chevron, Shell, and other icons of Big Oil -- to take on one of the world's biggest corporation in court. It's a true David v. Goliath saga, and the momentum from that case propels Stuart all the way to the 2010s and the legal fight against BP, which has poisoned his native Louisiana with 5 million barrels of crude oil. Along the journey, he takes on the behemoth that is ExxonMobil, rejecting a paltry offer of less than $10 million in a radioactive dumping case to ask a jury for more than $1 billion(!). As they say at Upworthy, you won't believe what happens next.
But it's also more than a legal thriller. While Stuart went into his odyssey to occasionally get justice for the Little Guy -- and, of course, make a few dollars for himself -- he came to realize over time that the whole fossil-fuels game was rigged. From fracking to drilling on the Arctic to its leaky pipelines, Big Oil does all it can to squeeze every last dollar in profit from the earth, and it has no regard for who gets hurt along the way. In the Big Picture, he pleads for America to ween itself off oil and gas, as quickly as possible. But Crude Justice also leaves behind another pearl: It makes you appreciate one of the most, ahem, underappreciated players in life -- the Great American Trial Lawyer. When you've been wronged by the oil giants, and when all the pols from both parties are in their back pocket, who else you gonna call? The justice that Stuart Smith wins for his clients may indeed be crude, but it is absolutely essential. And so is this book.
Here's some bad (or, "bad") news, which is that there's not going to be much Attytood in January, at least not from me anyway. I'm off a lot of this month, and when I'm here -- like a couple of days this week -- I'm going to be trying to wrap up other non-blog things.
The good news is that, on an issue of great public import, a local writer has channeled my thinking so much that I can proudly highlight his work. There's an old saying that, just because you're paranoid doesn't mean they're not out to get you. Likewise, just because Kathleen Kane is a train-wreck of an attorney general doesn't mean there's not a sleazeball "old boy network" out to get her.
There are few things in this world we can all agree upon, once politics casts its long shadow. But I doubt you'll find many who don't believe that today's rally and solidarity march in Paris -- on behalf of the satirists, the police officers and the Jewish victims of Islamic fundamentalist terrorism in France last week -- was one of the most moving and powerful events we've seen in the public arena for a long, long time.
More than 1 million people packed the expansive Place de la République and surrounding districts, in what experts believe was the largest rally in the history of France, which is pretty amazing when you think about all the political convulsions that have rocked Paris from 1789 to 1968 and beyond. The march was noteworthy for all the world leaders -- not just from Europe but also Israel's Benjamin Netanyahu to many Arab kings, presidents and prime ministers -- who for at least one day were in lockstep (and shame on President Obama for not being there, and on the presidential hopefuls who were tweeting the NFL but forgot Paris). But what stood out was the diversity of the crowd, including a healthy showing of the "moderate Muslims" who get accused of never speaking out against terror. To borrow a phrase, it was liberty, equality and brotherhood at its best, overwhelming a week of senseless violence and sorrow.
Of course, the march was not only a condemnation of terrorism but a celebration of both free assembly and free expression -- the thing that two murderous thugs tried to stop Tuesday in their attack on the satirical magazine Charlie Hebdo that claimed 12 lives, the start of a bloody week in which 17 innocent victims died across the Paris area. It's a pretty safe bet that 99 percent, give or take, of Americans had never heard of Charlie Hebdo before last week; I know I hadn't. But within minutes, many folks -- especially journalists, cartoonists, and others who've devoted their working life to some form of creative expression -- raced to tweet or otherwise voice solidarity with the victims. An attack on a publication on the other side of the world is an attack on all of us. "#JeSuis Charlie," or "I am Charlie." I wrote that last Wednesday, and I proudly stand by that.
What does it mean when police make arrests? When you think about it, it's actually a complicated thing. Does it mean that a community is teeming with violent lawbreakers that the officers in blue are systematically clearing from the street, Or are the cops following a commander's quota system, taking in suspects or issuing summons for lesser, non-violent offenses -- like, say, selling loose untaxed cigarettes -- that don't necessarily require a SWAT team.
Or, put another way, does arresting a lot of folks reduce crime in a meaningful way, or does it RAISE the crime rate through statistics by putting so many violations on the books? There's no arguing that America has the highest incarceration rates of any industrialized nation. But is that from too much lawlessness... or too much policing and prosecution?
Thanks to the NYPD, we may finally find out. In one of the most bizarre twists to a major national story that I've seen in a while, rank-and-file cops are now showing their contempt for New York City Mayor Bill de Blasio through a massive work slowdown. With the flow of arrest papers and summons slowed to a trickle, the city that invented "broken windows" policing -- the theory that more arrests for lesser "quality of life (QOL)" crimes like graffiti or drinking a beer in public will curb more violent crime -- has just pulled a 180:
One hundred years ago, the Great War was fought with Gatling guns and biplanes. Today, global conflict is over the keyboard and the drawing pen. Here's the news article based on the carnage in Paris that I wrote for today's Daily News.
One glitch was that one of the nation's leading experts on free speech issues, Kyu Ho Youm from the University of Oregon, who's currently visiting at Nanyang Technological University in Singapore, got back to me just a little bit after deadline. But I thought his responses to my emailed questions were so interesting that I'd publish them here (with several passages highlighted):
1) Is "Free expression" becoming the global war of the 21st Century?
This was the most recent (but hopefully not the last) image sent out on Twitter by a French left-wing, anti-religious magazine called Charlie Hebdo. It shows the leader of ISIS, Abu Bakr al-Baghdadi, and for an explanation (of sorts) here's a little more. It may or not have been the last straw for a band of armed thugs and losers who've complained for years about cartoons satirizing Islamic extremism and who burst into the magazine's Paris office today and killed 12 people -- including some of best-known satirical cartoonists in France -- and wounded eight more. It was not only one of the worst terror attacks in the West in recent years, it was the most heinous assault on the practice of journalism I can remember.
I certainly have a lot of thoughts on this, and so do you, but as often with the case on a big international story I've a little jammed pulling together something for tomorrow's newspaper. For now, know that this is a barbaric attack not just on journalism but on the basic rights we all share -- to express our opinions freely. I'm outraged and horrified -- my condolences to the loved ones and friends of those who died, to the wounded, and to the people of France. Those who continued to express their views in the face of terroristic threats (including a 2011 firebombing) are true heroes, and their killers are a bunch of gutless cowards.
For guy whose job largely involves writing about politics, I'm really coming to dread elections. Take the 2016 presidential race...please. Of course, all kinds of crazy things ($1-a-gallon gas, ExxonMobil filing for bankruptcy) could shake things up between now and the '16 conventions, but it's hard to avoid the dreadful feeling that Jeb Bush and Hillary Clinton will be our major-party nominees. I'll already beginning my research on which countries offer political asylum to Americans.
Today, Bush (do we just call him Jeb? John E.? Bush 45?) took his nascient campaign to Facebook, and it was a bad day at BlackRock. Literally...as he made his pitch to the common man by posing in front of a Wall Street investment house called BlackRock. He also said that income inequality is a problem (ya think?) but that it can be solved with "conservative principles." Perhaps -- I mean, conservative principles caused income inequality in the first place, right? I'd say Clinton 45 had a better day, but who knows what she's up to...probably speaking at some university that pays her $300,000 and sorts out the green M&Ms for her.


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Microsoft On List of Most Ethical Companies
samzenpus posted more than 3 years ago | from the a-nicer-domination dept.
465walterbyrd writes "Microsoft is among the world's most ethical companies, according to a list put together by the Ethisphere Institute in New York. Overall, 110 companies made the prestigious list, including Microsoft and 35 other newcomers. The complete list was reported by Forbes."


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So, what I thought to do today was share a little bit with you about our experiences sequencing primarily tumor samples. So, at OICR we're fortunate enough to have, you know, all of the toys and--with all the bells and whistles, and we can really select, you know, the various technology to go along with the various projects that we want to do and, you know, kind of use our expertise in sequencing to try and optimize the type of data we're receiving.
And mainly what we sequence are tumor samples, which come in all sorts of shapes and sizes. Largely we're dealing with biopsy samples, which can have either very little material in a given biopsy or you can get lots of tumor samples. Also, we're dealing with cellularity issues that--you know, tumors are extremely heterogeneous, both in, you know, normal stromal contamination within the tumor itself, and also with sub-clones within the tumor that can have different genetic profiles.
And then, you know, the big thing that we're dealing with is--are pathologists' favorite tool, the formalin-fixed material that can play all sorts of problems with our DNA samples. And so, these are the types of things that we're trying to deal with on a daily basis sequencing tumors.
And now, there's several different target methods out there. And the way we look at it is you pick your enrichment method based on what you're trying to do with the needs of your project. So, for a large-scale project, you might be looking at, you know, lots of targets, a large number of samples, using things like exome sequencing. But, with more of our clinical aspects, we've been using smaller targets and things like having a 100 percent coverage and fast turnaround become more important and being able to accept variable input from, you know, small biopsies, for example.
So, what I thought I'd do is I'd touch on two projects that we're currently working on, one large scale and one clinical project.
So, we're part of the International Cancer Genome Consortium, which is this worldwide project; 13 countries around the world. Our goal is to sequence, you know, between 20,000 tumors and various types.
In Canada, we're part of the Pancreatic Cancer Project, and so currently we're trying to get about 375 pancreatic cancer tumors. These are surgically resected in--mostly in Toronto. Some come from the US as well. A chunk of the tumor gets stored in our bio bank for long-term future studies, but we also take the primary tumor--we grow it up in mice xenografts so that we can have lots of tumor material. And then, we do all sorts of, you know, genome analysis to this thing.
So, one of these methods is we're using the SureSelect--the 50-meg target to do exome sequencing. We generally do about one high ceiling per exome, which gives us about 200x coverage, which is extremely important to have high coverage when you're dealing with these heterogeneous tumor samples.
To give you an idea of the number of variants that we're seeing--so this is the--each individual line is a different sample on the bottom, and this represents the number of predicted to be deleterious somatic variants that we're seeing per sample, but we're seeing about 18 to 30 on average. Interestingly, if you look at the cellularity of these samples, the higher cellularity samples we see more variants. Where we get down to some of these tumor samples, there's not much tumor in the chunk itself, and we're not seeing as many variants. So, this is kind of a bit of headache, and we're trying to tease this out.
When you start to look at the number of genes that are mutated in these samples, you know, the typical candidates pile up, K-ras, p53 and so on, but we actually have this tail of over 1,000 genes that we're seeing somatic variants in. So, you can imagine that this is a lot of work to try and follow up on all of these pathways and doing, you know, various types of analysis.
And even just trying to validate variants in tumor samples becomes a bit of a headache. And so, here's a quick example where, you know, just--we took PCR and amplified, you know, between 20 and 25 variants per sample and sequenced it using Sanger. We did other methods like Lapack Biowin [sp]. We can see that our validation rate differs depending on the depth of coverage and the type of sequencing technology.
Lee Tims [sp] has a poster on Thursday that talks about this whole verification pipeline and the problems associated with doing this in tumor samples.
So, I mean, this is a large-scale project, and I think the exome sequencing's proving to be--work really well. I think the key is to actually get lots of depth per sample, but the analysis is ongoing and will continue for the next several months.
So, to change gears a little bit, we're also looking at more of a clinical model to research cancer, and I think cancer is the perfect disease for this type of--because, obviously, it's a genetic disease, but we actually know a lot about somatic mutations that, you know, are predictive to be--provide benefits to targeted therapy. And so, with the latest in desktop or rapid sequencing technologies, we thought to undertake a project where we could sequence things and turn it around in a quick manner.
So, to give you a bit of a--more of a background on why we thought of doing this, if we just look at the number of somatic mutations in various cancer genes across various cancer types, we can see that while we are seeing the traditional ones, like BRAF mutations in melanoma samples or K-ras in colorectal, we're also seeing the same variants across multiple cancer types. So, the idea is that you could potentially think of tumors not based purely on what type of tumor it is, but more on the mutational load that it carries, and so there's opportunity to try and link treatments with these given biomarkers. And so, the challenge is, well, will this work, and what kind of clinical trial design do we need to do to actually show that this will work.
So, if you look at the current literature out, there really aren't many known actionable mutations, mutations that oncologists would actually consider guiding new therapy based on. They really fall into only a handful of genes. And so, you know, the groups at the Broad and Farber and so on, and MD Anderson, have started just using genotyping to look at these mutations and have screened between, you know, 200 and 1,000 samples. And what they're seeing is that around 30 to 40 percent of patients carry one of these known actionable mutations, and they can actually predict a therapeutic response to one of these.
So, with this in mind, this is where we set up to create our own trial where we recruited people with advanced metastatic disease. We didn't care what type of tumor they were, as long as they were a potential candidate for a clinical trial. Obviously, we needed to be able to biopsy their disease and that we needed adequate material.
To give you a bit of an overview of how this trial works, a patient comes in, gets consented for the trial, they undergo a biopsy through their radiology, we get blood as well so we can screen their germline genome as well--this all remains in the hospital clinical setting through tissue processing and DNA extraction. Up here, the sample gets split. We keep some sample always in the Cleo Lab so that anything can be validated without leaving the clinical setting. We receive an aliquot of the sample, undergo targeted sequencing, everything, as I mentioned, gets verified either by Sanger or Sequenom genotyping. This creates a final report that goes to an expert panel of clinicians and scientists that can generate this report and get it back to the patient. The key thing here is that we can do this whole pipeline. Our goal is to keep it under 21 days.
So, you can imagine that, you know, with the capabilities in next-gen sequencing and all the various assays and tests that we could do that you can envision reporting back something crazy and convoluted like this with the patient's genome and their metabolome and their--you know, all sorts of network and pathway analysis, but obviously this is just going to be completely overwhelming. And so, here's an example of the type of report that we print back to the physician. It has the name of the somatic variant, any relevant background information about this variant, the frequencies it's been seen in other cancer types, and any characteristics and potential therapies that are associated with it.
So, to give you a bit of overview, we're up to about 50 patients right now. We've been recruiting them from about five sites across Ontario. You can see that the primary diagnosis varies. As I said, we're cancer agnostic. But, what we have noticed is that the amount of material we get per biopsy and per site varies quite drastically. So, all of the biopsies get immediately fixed in formalin so that pathology can confirm the diagnosis and estimate cellularity. And then, we also, when we can--if they have a biopsy from their original diagnosis, we go and try to get that sample as well.
So, you can see that we're getting--you know, for these fresh, small biopsies we're not quite getting a microgram of DNA. Obviously, blood we're getting loads of DNA. And if we're lucky, we're getting on average just over a microgram for these archival.
The initial way we did this is we looked at the--things like the OncoCarta gene list. This is the Sequenom genotyping assay that covers 238 somatic--known somatic variants. So, what we did is we PCR amplify any exon that contains one of these variants. It's about 70 exons in total. After much optimization, we were able to multiplex this into 19 reactions.
We are continuing to expand, but one of the problems is, you know, just to amplify all the coding sequence for these 19 genes it's 400 amplicons and that multiplexing has become a bit of a headache. We plan to expand to about to about 200 genes in the next year or so, but as--to give you an example, to PCR those 200 genes, the coding sequence is around 6,000 amplicons. So, you can see that PCR, while it's working really well, it's just not scalable to increase our target size.
I mean, that being said, we're still seeing--finding somatic actionable mutations in about 30 percent of our patients. In addition to that, we've also found several novel somatic mutations that we've been following up with functional assays, and they seem to be interesting.
ohn McPherson [sp] is going to be talking about this project as a whole and kind of the plans to go on Friday, if anyone's interested.
So, the initial benchmark of the project was that we would find a variant in at least 30 percent of patients, and so the clinicians on the project are very happy because we're meeting our goals. But, you know, as a geneticist, I see that we're missing the mark in 70 percent of our patients. So, you know, I think it's probably because our target's not big enough yet, so this is where we're trying to expand this. And one of these ways that we're doing this is using this HaloPlex system.
So, our initial assay design was the complete coding sequence of these 19 genes. It's about a 61 kV target. And we've been pairing this with My Seek [sp] two-by-one 50 base pair reads. So, the result of that is that we're getting about two gigs of raw data, you know, almost 100 percent of map reads on target. And the nice thing is that we can go from library to sequencing analysis in just around three days, which fits nicely with our timeline of keeping it within 21 days.
So, I mentioned it's 19 genes. That's about 321 exons total. And you can see that using the Halo design report, they expected we'd have about 98 percent coverage. That's assuming a luminal two-by-100 high-seek runs. But, with the My Seek and the 150 paredine [sp] reads, we're actually getting, you know, over 99 percent coverage of our targets.
So, we've tried to throw as many different samples at this as possible, you know, things with high and low DNA content, FFP samples. The blue line here, this is a mouse sample. We sequenced a mouse to see how well that would work. And then, you can see that, you know, our average coverage is about 600x and that--you know, still at 50x we're getting over 90 percent of the targets covered.
I mentioned that we've got it down to 100 nanograms of DNA, and we don't see a significant drop off in coverage going down to a lower input. If we divide it by the type of sample--so here I have, you know, archival. These are--some of these FFP blocks are five to seven years old--blood. These are the fresh FFPs from the biopsy. We've started looking at whole genome amplified material, and we've done some of these mouse xenograft samples with the corresponding mouse and so on. And really, we're seeing a slight shift in the coverage curve for the FFP samples, but still, overall, we're getting, you know, five to 600x coverage and well over 90 percent at 50x.
This just shows you some more of these examples of comparing formalin fixed and blood at various input levels. And as I said, the formalin-fixed samples are showing a little less coverage, but still enough that we're happy with it. And here's the reproducibility. This is the same sample done 10 times, and you can see that some of these are within the same reaction runs, some of these are across multiple reactions, and we're getting a nice reproducibility.
Here's just looking at the coverage of these 321 targets. So, I guess, focus on the left now. So, these are all standard normal samples ranging between 100 and 900 nanograms. But, you can see that there are patterns. The coverage is consistent across multiple experiments. You know, we have peaks in the same areas and some valleys.
Where we start to see differences in the coverage--actually, interestingly, the only samples that we see this is when we have samples that are whole genome amplified or in the mouse sample. So, obviously, we know that whole genome amplification is not consistent across the entire genome, and it's preferentially amplified in certain areas. But, we're still getting coverage of every target.
So, more importantly for us, we wanted to look at the variants that are being culled. So, we try to run everything no matter sequencing technology we use. We have a standard pipeline where we can just take BAN [sp] files, cull variants, and that way everything gets processed the same way no matter what we're doing. So, if we look at just the number of--here are single nucleotide variants. And in those, you can see that across the various input levels it's consistent. Where we start to see this increase in the number of variants is when we look at the xenograft in the mouse model, and I'll touch on that a little bit later.
So, we had a lot of samples that had known variants, so this particular sample had a known K-ras variant, Q61H I believe. And you can see that testing the FFP sample at 900 nanograms, at 100 nanograms, and even the whole genome amplified we still can clearly identify the variant at around 60 percent, which is the proper percent of frequency.
In addition, where I get happy is now we've actually started to identify somatic variants that previously were unknown in some of these samples. In this example, we see that we had a heterozygote reference, and there's been a loss of heterozygosity in the primary sample. And we've actually confirmed this by Sanger sequencing, and this is a real variant that we're now following up functionally.
So, you know, one of the advantages of doing--of growing these tumors up in xenografts is that we can get a lot more tumor tissue and we can increase the cellularity. This particular sample, based on deep sequencing we estimated that it's--it was only about 4 percent tumor. And we can see that at about 4 percent, we saw this variant, which is what we would expect. Whereas in the xenograft model, we can actually--we see we've got a lot more tumor material, and we can amplify up this variant to about 73 percent, which makes things a lot easier to cull. Interestingly, in the mouse sample, there was a depth of about five there, but we didn't see any variants.
So, this can also be a bit of detriment because we often see things like this, and this is the reason that we're seeing more variants in mouse and xenograft models. If we look at the primary sequence, we'd see that nothing was culled and that the mouse--we see these homozygous variants that in the xenograft get culled as heterozygous, and these are simply just interspecies differences between the genomes. In this particular region of chromosome four in human and chromosome five on mouse, there happens to be four differences.
And so, we've done a lot of work to try and, you know, create databases of these interspecies variants, we're calling them, that can be filtered out. And when we do that, we can see that the number of variants actually goes back down to about the same for all sample types.
We've done some mixing experiments where we take cell line DNA for a tumor and mix it in various ratios with the corresponding reference material to see that--you know, if we can still detect variants at various cellularities. So, you can see here that at this point we only have 25 percent tumor and 75 percent reference, and we're still able to detect it at a rate around 15 percent, which is what you'd expect for a heterozygous variant.
For a loss of heterozygotes, we're seeing, you know, the opposite pattern to this where we're seeing the variant at about 50 percent in--for a heterozygote in the--when it's 100 percent reference and, you know, it goes down to about zero in a hundred when it's all cell line.
So, finally, I guess, recently we had some early access to the six-hour protocol, so this is--the nice thing about this is--for us, is in our hands we're able to go, in one day--get it in the morning, start the library prep and have it on the sequencer that afternoon. And we can see that actually the coverage so far in the samples we've done is even more consistent and just as high, you know, well over almost 95 percent at 50x. It's very reproducible. You know, there's a third line under here that you can't even see because it's exactly the same. And then, across various sample types at various inputs, we're still seeing this very consistent coverage. So, we're very happy that now we can change our whole protocol into a single day.
So, I just--I guess I'll conclude. So, if we look at--you know, there's a lot of talk on, you know, as the sequencing--the cost of sequencing gets lower and lower, you know, why don't we just sequence everyone's whole genome, why don't we just sequence everyone's exome, and then we can extract the data corresponding to the targets of interest?
So, here's just to compare to you--this is the coverage across these 321 targets for one sample, but I also took whole genome and exome data for this same sample. And we can see that, well, yes, the whole genome seems to be a little more consistent. Exome is a little more variable. Some areas are higher. Some areas are not covered at all. I guess the big thing we're talking about is time and cost. We're talking, you know, thousands versus hundreds of dollars, but, you know, weeks and months of actual library and sequencing and analysis versus, you know, we have this down to about two days to cover it.
In addition to that, obviously, we'd be dealing with, you know, huge numbers of variants when you start looking at a whole exome. So, these are just numbers--I averaged some numbers from some of the recent exome and whole genome papers, and we're talking about, you know, 75 to 200 potentially damaging mutations when we look at a whole exome, and this goes up to, you know, probably close to a thousand in a whole genome. So, just the headache of trying to deal with all this information, I mean, it just becomes completely unrealistic in a clinical setting to actually turn this around in a time that would be reasonable to affect patient care.
So, to summarize, you know, tumor samples are difficult for a number of reasons. We can have variant quantities, we can lots of heterogeneity within the--both within the sample and among samples that, you know, the method for enrichment for your given project is going to really depend on the needs; do you have a large target, a small target, how fast, how cheap, and do you want consistent coverage or 100 percent coverage? And that so far we've been very happy with this HaloPlex PCR. It's been rapid. We can get things on in a short period of time. And that when we combine it with a--you know, a clinical lab to validate any findings we make, it's going to be a--could be well integrated into a clinical trial setting.
And so, with that I'd like to thank everyone at OICR and our collaborators at Halo and have to recognize the government of Ontario for base funding. And I'd be happy to take any questions.


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Printable Area
By Moonmunkimama on July 12, 2009
Photo by gailanng
Photo by gailanng
"I had to post this online to preserve it so I could never loose it. It comes from www.TopSecretRecipes.com Tom Wilber has recreated BWWs Spicy Garlic. I love BWW sauce but hate the place. I was stoked to find this recipe."
Serving Size: 1 (341 g)
Servings Per Recipe: 1
"I made this just so I didnt have to get out in the yukky weather and as soon as the kids got home, they tore into it and put it on everything from hot dogs to ham and cheese sandwiches to breakfast burritos, I was able to get about a tablespoon to dip celery in before it was gone. Simple to make and so good to eat, just scaled the recipe to make 6 cups, then will try for gallon next. Maybe it will last longer than an hour this time."
"Awesome!! My husband and I always get spicy garlic wings from BW3 and I think this sauce is even better! We are making it again tonight (second time this week).
I used 1-1/3 cups Tennessee Sunshine instead of 1 cup of Franks; and butter instead of the oil, and it was delicious.
We mixed some with BBQ sauce for our son and it was really good too. I'm thinking of trying some with a dash of sesame oil too."
"I am a full-fledged Spicy Garlic authority and I agree with schertmark that this is the closest version of BWW's Spicy Garlic sauce. I also (accidentally) found that you can use an egg white instead of a yolk and it turns out just fine."
"Even BETTER than the original at BWW!!! Made it once and made it 10 more times! I LLLLLOOOOOOVVVVVVEEEEEE it!!!!"
"Amazing recipe!! I LOVE the buffalo wild wings spicy buffalo sauce and this tastes just like it. I LOVE IT."
"we used this on tofu and it worked really well! Tastes like the real thing. The only thing we did different was to cook the sauce a bit more after adding the egg white as we are skeptical of raw eggs - it didn't effect the consistency at all"
"This is a great recipe, just as good as BW3's sauce and it's easy to make it spicier (more cayenne or fresh pepper puree) if you like. I love it, thanks!"
"This came out super tasty. I only used half of the cayenne, and it came out really really spicy. But I tossed the wings to coat them in the sauce instead of dipping them, so that might have contributed to the extra spicy factor. I also added two cloves of garlic that I put through my garlic press, which I think added to the deliciousness."
"this is amazing. tastes just like the real thing. I added a little extra garlic, pepper, and franks hot sauce. This is def a keeper. no need to buy sauce from b-dubd now."
"If you really like garlic, you can use cloves as well. I did, and I did not regret it!"
"Care to join me in olfactory drama? Then make this recipe."
"I thought this was quite good, a nice sauce for wings and even for chicken on the grill, but I had never had the restaurant verion. My husband LOVES the Spicy Garlic Sauce from BWW so that's why I chose to make this recipe. He says 5 stars for being very close to the restaurant version. I'm so glad I can make this at home, with everyday ingredients I would typically have on hand. I'll definitely be making this one again soon."
"This is right on the money an excellent copycat closes I've ever had thanks for sharing. Great sauce"


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Bulldogs overcome 4 goal deficit for 4-4 tie.
The Siun Devils raced out to a 4-0 lead, but the short bench could not hold it. The red Bulldogs got a pair of goals from Jon Morin as he threw the Dogs on his back to salvage a 4-4 tie.
Perhaps being in first place all season has the gold Sun Devils a little complacent.
The newest Devil John Ragucci had a pair of goals, while Onello and Danaher had single tallies as the Sun Devils were cruising with about 6 minutes to play in the 2nd period.
Thoughts turned from hockey to the holidays on the gold bench, that's how happy they all were.
The Bulldogs though quietly chipped away at the four goal lead. Jon Morin and Marc Teal found the net before the 2nd period ended. Then in the third, the pattern repeated itself, as both Morin and Teal scored again to tie it at 4-4.
Rob Chiulli was on the ice for all 8 goals in his throwback white jersey.
OT came and went without a goal, which was a moral victory for the Sun Devils who "hung on" for the tie after blowing a 4 goal lead.
"We're like the St. Louis Rams," said Tony Onello. "We have a strong first half, then fall apart like a house of cards."
The tie now drops them out of sole possession of first place, and into a tie with the surging Ducks who won in OT in the other rink.
Hockeytown A; 17-Oct-2014 06:00 AM; 2014 Regular; Friday
Sun Devils (Friday) 4 vs Bulldogs (Friday) 4 OT
First Period
1. Sun Devils, Ragucci, John (Chiulli, Rob) 10:18
2. Sun Devils, Onello, Tony (Danaher, Gavin / Johnston, Lloyd) 13:52
Penalties - None.
Second Period
3. Sun Devils, Ragucci, John (Steigerwald, Jake) 10:02
4. Sun Devils, Danaher, Gavin (Chiulli, Rob) 12:46
5. Bulldogs, Morin, Jon (Smith, Joe) 16:27
6. Bulldogs, Teal, Marc (Melito, Mark) 17:06
Penalties - None.
Third Period
7. Bulldogs, Morin, Jon (Melito, Mark / Osbahr, Bill) 03:25
8. Bulldogs, Teal, Marc (Smith, Joe / Peterson, Al) 12:20 (gt)
Penalties - None.
First Overtime Period
No Scoring.
Penalties - None.
Goal - Sun Devils: Boccuzzi, Mike; Bulldogs: Fuji, Tom
Power plays - Sun Devils: 0-for-0; Bulldogs: 0-for-0
Officials: Vin, Adam


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Your Satisfaction is Guaranteed:
Yossarian says, "You're talking about winning the war, and I am talking about winning the war and keeping alive."
"Exactly," Clevinger snapped smugly. "And which do you think is more important?"
"To whom?" Yossarian shot back. "It doesn't make a damn bit of difference who wins the war to someone who's dead."
"I can't think of another attitude that could be depended upon to give greater comfort to the enemy."
"The enemy," retorted Yossarian with weighted precision, "is anybody who's going to get you killed, no matter which side he's on."
Mirabile dictu, the book holds up post-Reagan, post-Gulf War. It's a good thing, too. As long as there's a military, that engine of lethal authority, Catch-22 will shine as a handbook for smart-alecky pacifists. It's an utterly serious and sad, but damn funny book.
1. |
Catch 22
Heller, Joseph Quantity Available: 1
Book Description: Book Condition: Brand New. Book Condition: Brand New * All orders are processed and shipped from Las Vegas, NV USA *. Bookseller Inventory # 97808085140221.0 Bookseller & Payment Information | More Books from this Seller | Ask Bookseller a Question |


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Eric Asimov on how to pick the perfect wines for turkey day. New York Times
Washingtonians vote to privatize liquor sales. Seattle Times
The Chinese wine industry gains momentum. Reuters
Is coconut water more than just a passing fad? Slate
Looking to start a wine collection? These tips will get you going. Wall Street Journal
Exploring the evolution and nostalgia of the red Solo cup. NPR
Welcome to Imbibe Magazine's between-issues look at liquid culture with drink recipes, news and more. From coffee to cocktails, Imbibe celebrates your world in a glass.


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Changes related to "Researching Court Records"
From Ancestry.com Wiki
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category).
Pages on your watchlist are bold.11 January 2015
- (diff) (hist) . . m Overview of Court Records; 23:23 . . (-3) . . Affiliate141 (Talk | contribs) (→External Links: )


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The butterfly lives in a seamless realm, a matrix, poetically in the palm of God/dess's hand, not alien or estranged. Is it possible for us to find that kind of confidence, or trust in the nature of the Universe itself? Let's take a moment or two to think about Wisdom, and our place in the Universe. What kind of liturgy, or worship experience, would celebrate the kind of inclusive, nurturing community the butterfly knows without thinking about it?
read moreNow the star of Christmas
shines into our day,
points a new direction:
change is on the way –
THEME: The Interplay Between the Inner and Outer Worlds. The Journey to the place where we once began
read moreOut of this house where there is no room
For the little ones that to him belong
(He is weak but he is God)
This is no time for a child to be born,
With the earth betrayed by war & hate
And a comet slashing the sky to warn
That time runs out & the sun burns late.
The outside shed where Jesus lay
Was home to goat and ox;
It was a dirty place to be;
Fit for the shepherds' flocks;
Who is this Herod in my heart
That seeks to kill the child?
It is the one who measures life
Till all is weighed and filed;
Jesus was executed by the Romans and died a tragic death. But then afterward, we hear the voice of God's messenger telling the women who had come to the tomb to anoint Jesus' dead body with spices: "He is not here, He has been raised." God validated and vindicated Jesus' life, message, and ministry by raising him from the dead. God had not abandoned Jesus. God was with Jesus through the whole ordeal. And when we get to the end of Matthew's Gospel the cosmic Christ tells the disciples, "I will be with you through everything, even until the end of the age." The Really Real, the risen Christ, the cosmic Christ, the Holy Spirit (use whatever name you prefer) is with us through all of life, in times of joy and hope, and in times of pain and disappointment.
read moreIn Matthew's midrash of Isaiah's prophecy, Jesus tours all over Galilee, teaching in the synagogues, curing all kinds of diseases, and proclaiming that God's kingdom has come. The verses in Chapter 4 selected by the creators of the Revised Common Lectionary for the third Sunday after the Epiphany are the preface to Matthew 5:1 through 7:29, the great Sermon on the Mount. Jesus walks by the Sea of Galilee, and invites his disciples to leave their nets and become "fishers for people," traditionally interpreted to mean saving souls from hell. But John Dominic Crossan, points out that Jesus could have brought his message anywhere in Roman occupied Judea. Why Galilee? Why Capernaum?
read moreIn the midst of the liturgical progression from Epiphany to Lent, tradition calls the church back to the mundane details of Jesus' infancy. Luke's Chapter 2 fills in the story from birth to circumcision to presentation as the first-born son to the coming-of-age of a gifted religious leader anointed by God. In The First Christmas (HarperOne, 2007), Marcus Borg and John Dominic Crossan suggest that Luke's purpose was to set up the birth of the Jewish Messiah as a counter to the birth of the Roman Caesar – also hailed as the "Savior, Redeemer, Son of God." The scene in the temple in Jerusalem confirms the child Jesus as the expected one who would redeem Israel from bondage to imperial injustice and oppression.
read moreHigh steppin' camels one by one
See the wise men boogaloo
Down to Bethlehem to have some fun
In this New Year, let us lift our vision of what we can do and what we can achieve:
read more


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Social apps are a dime a dozen so when I come across an app or service that immediately proves it's value I am inclined to share. This website and app is a social network for your neighborhood. It's called Nextdoor and It's not Facebook and it isn't meant to be. You only connect to your neighbors.
From Nextdoors website:
I signed up and was surprised to see how many of my neighbors were already using Nextdoor. Additionally once I signed up they gave me the option of having Nextdoor send out 20 postcards to people in my neighborhood that haven't signed up yet. I personally am using it for crime-watch and to build stronger relationships with my neighbors. What do you think? Sound off in the comments if this is something you see value in for your neighborhood.
Source: The Verge


text:
FREE Email Newsletter
Federal Register: Circulatory System Devices Panel of the Medical Devices Advisory Committee; Notice of Meeting
February 18, 2010 9:41 am | by FDA (The Center for Devices and Radiological Health) | CommentsOn March 18, 2010, the committee will discuss, make recommendations, and vote on the premarket approval application (PMA) for the Cardiac Resynchronization Therapy Defibrillators (CRT-Ds) sponsored by Boston Scientific.
Erythropoiesis-Stimulating Agents (ESAs): Procrit, Epogen and Aranesp: Drug Safety Communication
February 18, 2010 9:40 am | by FDA MedWatch | CommentsFDA requires REMS that ensures that only those hospitals and healthcare professionals who have enrolled and completed training in risk management program will prescribe and dispense ESAs to patients with cancer.
Maalox Total Relief and Maalox Liquid Products: Medication Use Errors
February 18, 2010 9:40 am | by FDA MedWatch | CommentsConsumers who have a history of gastrointestinal ulcers or a bleeding disorder should not use Maalox Total Relief because it contains bismuth subsalicylate, a substance chemically related to aspirin.
Exjade (deferasirox): Boxed Warning
February 18, 2010 9:40 am | by FDA MedWatch | CommentsChanges to Prescribing Information re: risk of renal impairment/failure, hepatic impairment/failure or gastrointestinal hemorrhage.
Corporations, agencies infiltrated by hacking
February 18, 2010 9:34 am | by JORDAN ROBERTSON - AP Technology Writer - Associated Press | CommentsSecurity experts have found a network of 74,000 virus-infected computers that stole information from inside corporations and government agencies. The find reflects the dangers of having computers with sensitive data connected to the open Internet.More than 2,400 organizations, including...
Voxware narrows fiscal 2nd-qtr loss as costs dip
February 12, 2010 3:01 pm | by The Associated Press | CommentsVoxware Inc., which makes voice-driven software for use in warehouse operations, said Friday that its fiscal second-quarter loss narrowed as costs fell.For the quarter ended Dec. 31, Voxware reported a loss of $528,000, or 7 cents per share, compared with a loss of $1.7 million, or 26 cents per...
Capital projects questioned in lean budget year
February 12, 2010 2:01 pm | by BARRY MASSEY - Associated Press Writer - Associated Press | CommentsWith New Mexico cutting schools and health care services, lawmakers fumed Friday over a proposal to finance economic development projects benefiting corporations like the Hewlett-Packard Co.A proposal to allocate $38 million for capital improvements passed the Senate but not before several...
Google tweaks Buzz social hub after privacy woes
February 12, 2010 1:01 pm | by BARBARA ORTUTAY - AP Technology Writer - Associated Press | CommentsAs it introduced a new social hub, Google quickly learned that people's most frequent e-mail contacts are not necessarily their best friends.Rather, they could be business associates, or even lovers, and the groups don't necessarily mix well. It's one reason many people keep those worlds...
Rovi reports 4Q profit; beats Wall Street views
February 12, 2010 1:01 pm | by The Associated Press | CommentsRovi Corp. on Friday reported a profit in the fourth quarter as the company benefited from an increase in revenue and the absence of a loss from discontinued operations in the same quarter a year ago.Rovi, which provides TV listings data and related services, said Thursday that it earned $2.6...
Brazil opens the first home-grown Chip Fab south of the Rio Grande
February 12, 2010 11:39 am | by Alix L. Paultre | CommentsThe Chip de BOI (literally, "the Ox chip") is an excellent startup product for the nascent south-of-the border firm CEITEC. The facility, located in Porto Alegre , is the first of its kind south of the Rio Grande.
Justice wants cell-phone locations without warrant
February 12, 2010 9:36 am | CommentsShould the government be able to track your movements based on cell-phone records, without evidence of criminal wrongdoing? A legal showdown on the closely watched issue unfolded Friday in a federal appeals court in Philadelphia, as the Justice Department battled electronic-privacy groups.
Seeking comeback, Microsoft to show phone software
February 12, 2010 9:34 am | CommentsMicrosoft Corp. is expected to announce a major revamp of its phone software Monday, in an attempt to regain momentum in a crucial market where it's been overshadowed. CEO Steve Ballmer will be speaking at Mobile World Congress in Barcelona, Spain, the world's largest cell phone trade show, and analysts expect him to reveal Windows Mobile 7.
DirecTV suing Dish for ads saying it's cheaper
February 12, 2010 9:31 am | CommentsSatellite TV provider DirecTV Inc. is suing its rival, Dish Network Corp., for running an advertisement claiming that Dish delivers the same programs for less money. The TV commercial shows three TV sets broadcasting the same programs, with Dish costing $39.99 a month, DirecTV costing $63.99 and cable TV at $63.83.
General Dynamics awarded Army training contract
February 12, 2010 9:01 am | by The Associated Press | CommentsGeneral Dynamics Corp. said Friday that it has been awarded an Army training contract that could potentially be worth $387 million.The contract is for work on the Army's computerized simulations that are used to prepare soldiers for situations such as combat. It has an initial value of $56...
Video Industry Needs to Migrate Digital Rights Management Towards Content Monetization
February 12, 2010 8:55 am | by In-Stat | CommentsCopy protection, watermarks, digital fingerprinting, and conditional access are all Digital Rights Management (DRM) technologies used to enforce copyright protection of video content.


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Talk of Iowa
2:05 pm
Mon April 1, 2013
A Thing Called The Divine Fits and IPR's Java Blend
The band, Divine Fits, has been billed as an indie rock super group. The band was co-founded by Britt Daniel, most famous as the frontman for the band Spoon, and Canadian Rocker Dan Boeckner, of the bands Wolf Parade and Handsome Furs. Last year they released their first album, "A Thing Called Divine Fits."
In the second part of the program, the music continues! The host of IPR's "Java Blend", Ben Kieffer, shares his experiences over the years, interviewing musicians from Iowa and across the country.


text:
Griffin, CEO of Citadel, defended the industry as one that has helped market participants and lowered costs, but is also populated by firms that have to jealously guard their strategies and keys to success. "What's shocking to those of us in the community is how many important ideas can be expressed in two sentences," Griffin said Wednesday at the Delivering Alpha conference presented by CNBC and Institutional Investor. "Because they are often very simple to record, you have to be careful how you express those ideas."
In Michael Lewis' controversial and much-discussed book "Flash Boys" released earlier this year, Citadel was cited in an anecdote for its secrecy. One passage noted that it took an employee five ID card swipes simply to start her day. Griffin said that's probably about right, but he refused to apologize for the steps his firm takes to guard its intellectual property.
Comments (20)
oh yeah, well I have to swipe 8 times to start my day.
-guy who makes everything a pissing contest
To get into UBS at Stamford all you need is to be wearing socks OR shoes
…but yeah.
and this guy testified before Congress as though he was impartial?
This mother fucker tried to burn my god damn dick off!
Stop commenting.
yeah but you also have to walk by 3 smoke shows at 3 reception desks on your way to your desk at 131 s dearborn
Sucker, I only have to rub mine twice to get my day started
go on.
-guy who needs this -
Have to say, Kenny boy is looking pretty sporty these days. Either he has been exercising and dieting or has AIDS.
When someone looks thinner, your default assumption is that they have either been exercising/dieting or have AIDS?
And yes, I *know how to use the reply button* I just wasn't paying attention
AIDS affecting your focus?
Did you eat a lot of paint chips as a kid?
"hmm" guest is clearly going through some personal problems
"guest" or "Guest"
-really good at proof reading
BNP requires one functioning chromosome and a scarf must match your shirt. No capital markets experience required, you can learn on the fly. Of course we lend to terrorist nations, their money is green just like yours and mine! Mondieu!!
Watch it! BNP laundered all of my money and it came out clean as a whistle after Captain Phillips came out
No, hunger.
What do you think about this investment in Poland? https://www.indiegogo.com/projects/eco-fuel-becom…


text:
Siegfried Lenz, one of the great writers of German post-war literature is dead. He died on 7 October 2014, surrounded by his family. He was 88 years old.... more
With her first novel "The Hour Between Dog and Wolf," Silke Scheuermann has written her way into the top league of young authors. The story is, once again, of young women saddled with privilege and boredom. But the language is cool, underwater movement and its author as intelligent as she is subtle. By Ulrich Greiner
read more


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As suggested by prior blog posts, I am no fan of the direction the CFPB, OCC and FDIC seem to be going with respect to payday and deposit advance loans. These agencies have all signaled a willingness to prohibit these loans without regard to Dodd-Frank's definitions of the terms "unfair" and "abusive" and without applying the cost-benefit analysis required by the statutory language. My concerns are articulated in some detail in a comment letter I submitted to the OCC and FDIC yesterday on my own initiative. The apparent regulatory approach— which involves the substitution of visceral reactions in place of rigorous analysis—has disturbing implications that go well beyond the impact on payday loans and deposit advances.
Topics: CFPB, Deposit Advances, FDIC, OCC, Payday Loans
Published In: General Business Updates, Consumer Protection Updates, Finance & Banking Updates
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
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Donald GoodrichDonald Goodrich
SALISBURY Donald Chief Goodrich, 84, died Saturday, March 30, 2013, at his home following a brief illness.
He was born June 10, 1928, in Salisbury, the son of Wilbur and Irma (Douglas) Goodrich.
He married Mildred Phelps on Sept. 3, 1949, in Chittenden. Together with his wife, they operated the Goodrich Farm in Salisbury since 1955.
He enjoyed family gatherings, hunting trips, and working on his property in Illinois.
Survivors include a son, Ernie Goodrich of Salisbury; three daughters, Donna Lawton of Bridport, and Debbie Goodrich and Penny Supernaw, both of Salisbury; 10 grandchildren and eight great-grandchildren.
He was predeceased by his wife Mildred on April 5, 2009, a daughter Roxanne, and an infant.
A memorial service will be held Friday, April 5, 2013, at 1:30 p.m. at the Salisbury Congregational Church. The Rev. John Grivetti, pastor, will officiate.
Burial will follow in West Side Cemetery in Salisbury.
Memorial contributions may be made to the Salisbury Congregational Church at Main Street, Salisbury, VT 05769; or to the Addison County Home Health & Hospice at P.O. Box 754, Middlebury, VT 05753.
Arrangements have been entrusted to the Sanderson-Ducharme Funeral Home in Middlebury. www.sandersonfuneralservice.com.MORE IN ObituariesAgnes M. Reed Full StoryMilton A. Wilk Full StoryJames S. Hackett Rites Full Story -
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Reviewed Pork Tenderloin with Seasoned Rub
Oct 3, 2011 in Food Network Community Toolbox on FoodNetwork.com
"This was GREAT. It was delicious, the flavor was outstanding. I scooped out the garlic to prevent it from burning. The tenderloins were extremely tender and juicy. My husband couldn't get enough. I will definitely make this again."""