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Latest Headlines
Back in April, Merck rolled out its America's Diabetes Challenge: Get to Your Goals campaign, aimed at persuading patients to do what it takes to keep their blood sugar in check. Now, Merck has a new-but-similar campaign launching, but with a tighter focus: the Hispanic community, which is disproportionately affected by the disease.
Best-selling drugs did well for themselves in 2013, churning out more than $76 billion in sales. But big-name brands could stand the test of time and help the top 10 rake in more than $80 billion in 2020, according to a new report.
On this list of the best-selling diabetes drugs, you will find a mix of the old and new. According to data from EvaluatePharma, one of the big dogs of big pharma data, these top 10 drugs had more than $28 billion in sales last year. All of them, even number 10, were blockbusters.
On the Big Pharma scorecard, Merck remains on a downward slide. Yes, third-quarter earnings beat estimates, but expectations were low, and it was cost-cutting that delivered the day. And though the Singulair drag on Merck's top line is easing up a bit--pulling overall sales back by 4%, rather than 9% in the first quarter--the Januvia malaise continues.
As it announced cuts to its full-year sales forecast in July, Merck was able to point to growth in sales of Januvia and its offshoots, if only in the low-single-digit range.
The group of drugs, known as incretin mimetics, was cleared last week by FDA's counterparts in Europe.
Merck cut its sales forecast and posted a 50% drop in quarterly earnings as it continues to absorb major hits to its once-blockbuster Singulair. The fact that profits beat analyst expectations says as much about those expectations as it does about Merck's performance for the quarter.
Merck's Indian unit won an injunction in a patent fight over its diabetes drugs Januvia and Janumet, blocking generic versions of the two drugs to be made by Indian drugmaker Aprica Pharmaceuticals.
The prevalence of diabetes is growing globally, and with that the size of the diabetes drug market. But the market has gotten increasingly competitive and increasingly complex. All of the top 10 best-selling drugs in the diabetes category are blockbusters, according to EvaluatePharma. So who makes them? Check out the report >>
Pressure is building to take a deeper dive into the cancer risks of incretin mimetics, a class of drugs for Type 2 diabetes that includes blockbusters like Merck's Januvia and Novo Nordisk's Victoza.
Press Releases
- FDA expands approved use of Imbruvica for rare form of non-Hodgkin lymphoma
- Cepheid Reports Fourth Quarter And Full Year 2014 Results
- Ortho Clinical Diagnostics and Quotient Announce Agreement to Commercialize Innovative Transfusion Diagnostic Platform, MosaiQ
- FACT SHEET: President Obama's Precision Medicine Initiative
- Valeant Selected As Lead Bidder To Acquire Dendreon And Its Leading Immunotherapy Treatment, PROVENGE® (sipuleucel-T)
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Hear Arcade Fire Reverently Cover Prince's 'Controversy' in His Hometown
Band's set also sprinkled bits of songs by Lady Gaga, Guns N' Roses, and Aerosmith
"FUNKNROLL." That's the title of a new song Prince debuted last week. And it's an obvious prophesy his path and that of recently funked-up indie-rock heroes Arcade Fire could not remain uncrossed for long. Over the weekend in Minneapolis, Minnesota, the Reflektor-ers covered the Purple One's 1981 Controversy title track, and as you can hear below, it's brassy, percussive, and sure to get Prince's hometown crowd in a festive mood. According to Stereogum, Win Butler was wearing a box-shaped mask with the face of first Prince and then Minnesota pol Michele Bachmann during the performance.
The song had been on the set list for the U.S. tour opener last week, but the band had opted instead for the Rolling Stones' "The Last Time"; the Minneapolis set also featured snippets of Lady Gaga's "Do What U Want," Guns N' Roses "Sweet Child O' Mine," and, um, Aerosmith's "I Don't Wanna Miss a Thing." Local radio station The Current broadcast the whole show, and @ArcadeFireTube captured the audio for "Controversy," below.
Though Owen Pallett and Arcade Fire's Will Butler missed out on an Oscar for Best Score, the Canadian band recently hit Jimmy Fallon's Tonight Show. Prince just played a four-hour Hollywood show, after which, if he cooked any breakfast, it was more likely to be omelettes than his famous pancakes.
Don't miss our list Inorganic at the Disco: 40 Rock Bands Who Beat Arcade Fire to the Dance Floor.

subset: commoncrawl


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Nah. I dont even know who the second team is. I did get a whiff that the 49ers were involved.Is the whole Family Frijoles going to a sports bar to watch the big game?!
The wife is making wings and Mexican layer dip.
But in fairess to me, that counts as dinner too!
I bought an acoustic guitar yesterday on impulse and I think I will spend the afternoon figuring out how to play it.
Wings- mmm. Tomorrow I have a business lunch date at a burger bar and I cant wait. Havent had real red meat in weeks.


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1 to 4 (of 4 reviews) |
December 2, 2012
I got a 12 pack of these...
I got a 12 pack of these pens with 9 black and 3 blue this summer (not through
JetPens). When I took them out of the packaging, they wrote horribly-I couldn't
keep a steady ink flow and several times in one sentence I would have to
scribble on a scrap of paper to get it writing again, so I stuck them in a
drawer. Just recently I pulled one back out to try it again and it wrote
wonderfully. It is very smooth and the ink is very dark, and I have had
virtually no trouble with the ink flow. The only bad thing I can say now is
that the ink gets used up fast, but that is because I have been using it for
everything for about a week and a half and there is a noticeable difference of
about an inch in the ink level between the one I have been using and a new one.
I don't know what caused them to not work originally but now they are amazing
and I would recommend them.
2 people found this helpful
July 1, 2014
I owned a pen like this...
I owned a pen like this fella before it was stolen. It was a really a very good
EDC pen, too. It gave out shockingly clear and bold ink on paper every tine I
use it. I highly recommend this one rather than the 1mm (too bold and thick, if
you ask me). It's no Power Tank or even a Space Pen, but if you want a
reliable every day pen that's easy on the wallet and gives out clear ink, get
this one. You won't be disappointed.
September 20, 2013
This pen is very comfortable...
This pen is very comfortable and writes smoothly. It's almost like a gel pen,
but dries much faster. The only problem is that there aren't any refills, but if
you love the pen as much as I do, you won't mind buying the whole pen. A great
deal is buying them in a pack of 4 at Staples or Office Depot.
April 28, 2013
Good ballpoint like ink,...
Verified Purchase
Good ballpoint like ink, a bit glossy but not so much.
1 to 4 (of 4 reviews) |


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"I added in some tomoatoes and just used some onion flakes, as my husband doesn't like onions...either way...this recipe is REALLY good! I found that by adding in more cucumber, it'll soak up the extra liquid. Oh, and I also used reduced fat sour cream! Thanks for sharing!"


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FCPA Compliance and Ethics Report-Episode 124, The Oscars and Compliance, Part I with Jay Rosen
FCPA Compliance and Ethics Report-Episode 123-Jim Moore on Translations as Preventative Tool in FCPA Compliance
FCPA Compliance and Ethics Report-Episode 122-with Matt Kelly on Alstom, Avon and Petrobras
FCPA Compliance and Ethics Report-Episode 121-FCPA Year in Review, Part II
MacEwen: Law Firm M&A Demands 'Cultural Due Diligence'
FCPA Compliance and Ethics Report-Episode 120-Prof. Andy Spalding on the problem of hiring family members under the FCPA
FCPA Compliance and Ethics Report-Episode 119-FCPA Year in Review, Part I
Why Every Day Is Proxy Season for Public Companies
FCPA Compliance and Ethics Report-Episode 118-the Alstom FCPA Enforcement Action
FCPA Compliance and Ethics Report-Episode 117-the Avon FCPA Enforcement Action
FCPA Compliance and Ethics Report-Episode 115-Tom Fox and Matt Kelly on COSO, Bruker Corp, Dallas Airmotive and Alstom
The FCPA Compliance and Ethics Report-Episode 114-Doing Compliance, The Book
FCPA Compliance and Ethics Report-Episode 111-Virna Di Palma on the TRACE Matrix
FCPA Compliance and Ethics Report-Episode 110-interview with Jonathan Armstrong
FCPA Compliance and Ethics Report-Episode 109-interview with Bill Michael on the SEC FCPA enforcement action against FLIR employees
FCPA Compliance and Ethics Report-Episode 108-Supply Chain Under the FCPA
fcpa Compliance and Ethics Report-Episode 106-interview with Gini Deitrich
Jeff Bell Video Law Bulletin: Unusual Purchase Price Methodologies in M&A Transactions
Zimmermann: "Two Class" Partnership Culture Emerging in BigLaw
FCPA Compliance and Ethics Report-Episode 104-interview with Russ Berland
On December 29, 2014, the Small Business Administration ("SBA") issued a proposed rule to implement the subcontracting limitation requirements mandated by the National Defense Authorization Act of 2013. Buried therein was a...more
On November 24, 2014 the Small Business Administration ("SBA") Office of Hearings and Appeals ("OHA") found that a mentor-protégé joint venture agreement between Kisan Engineering Company P.C. ("Kisan"), a small 8(a)...more
Aerospace and defense contractors engage in a wide range of mergers, acquisitions and joint venture transactions. Like all companies, aerospace and defense contractors need to be sensitive to antitrust considerations that...more
In this presentation: - M&A Landscape/Deal Structure - M&A Landscape/Deal Structure - Third Party Sale Alternatives - Excerpt from M&A Landscape/Deal Structure: Presentation Goals - -...more
We expect 2015 to be a very busy year for actions on new or proposed federal regulations in the absence of congressional legislation. That was confirmed on November 21, 2014, when the administration published its "Unified...more
It's well known that Medicare, Medicaid and commercial insurers hate the ever-increasing trend of hospitals buying facilities and practices and then charging provider-based (i.e., higher) rates than the facilities and...more
In this issue: - Court of Federal Claims Invalidates Key Component of the SBA's Nonmanufacturer Rule - At the Crossroads of M&A and Government Contracts – The Novation Process - What Every Business Owner...more
The U.S. defense industry is facing a new battle – financial distress. Withdrawal of U.S. forces from Afghanistan and Iraq combined with reductions in the defense budget and sequestration have taken a toll on many U.S....more
The US Department of Defense has published an Interim Final Rule assigning responsibilities and establishing requirements related to the National Industrial Security Program (NISP). See 79 Fed. Reg. 19467....more
In this presentation: - Federal Market Overview and M&A Trends II - Value Creation Strategies - Introduction to Aronson Capital Partners - Excerpt from Value Creation Strategies: - Key contracts are a...more
Recent developments in Canadian anti-corruption, economic sanctions, and export control laws are having a significant impact on the due diligence that should be conducted on potential targets in the context of mergers and...more
The Department of Defense and the General Services Administration, which together spend more than $500 billion annually on information technology, have released a joint report to the White House recommending steps to upgrade...more
Will the Bitcoin Become a New Tax Evasion Tool? by Joseph M. Donegan on August 19, 2013 Bitcoins, a controversial but highly popular global digital currency, is being used by more consumers to make several types of...more
On April 1, 2013, the U.S. Court of Appeals for the Sixth Circuit overturned an $11.1 million False Claims Act (FCA) judgment by the U.S. District Court for the Middle District of Tennessee against MedQuest Associates, Inc.,...more
How will the FY 2013 National Defense Authorization Act impact your business as a government contractor? The recently passed National Defense Authorization Act for Fiscal Year 2013 ("NDAA") includes a number of...more
In a recent decision, the Federal Aviation Administration's ("FAA") Office of Dispute Resolution for Acquisition ("ODRA") sustained a protest challenging the intent to award single source contract because, according to ODRA,...more
After negotiating an agreement for his client John, Attorney signs the agreement at the end stating that the agreement is "approved as to form and content." A dispute arises between John and the other party, Mike. Now Mike...more
With Congress unable to pass cybersecurity legislation by the August recess, the executive agencies are proceeding to regulate government contractors with access to government information. Specifically, on August 24, 2012,...more
Originally published in Federal Contracts Report, 98 FCR 210 on 08/14/2012. The mid-90s were a watershed for the federal procurement system. The Federal Acquisition Streamlining Act of 1994 (FASA) and the Clinger-Cohen...more
The mining code of the Democratic Republic of Congo [DRC] provides for a possibility of leasing and assigning mining and quarry rights. Since mining and quarry rights, as expressed in mining and quarry permits, are real and...more
On May 16, 2012, the U.S. Small Business Administration (SBA) issued a lengthy set of proposed regulations implementing various sections of the Small Business Jobs Act of 2010....more
In This Issue: • Federal Acquisition Regulation (FAR) updates • Defense FAR Supplemental (DFARS) updates • Industry topics ..Defense Contract Audit Agency (DCAA) Audit Guidance...more
Notes to accompany slides for TUPE presentation at ELG Conference on 1 June 2012. Paper provides an update on the most recent TUPE cases particularly in relation to cases on service provision change (what is an activity,...more
The lesson for all companies conducting operations in China, especially if affiliates or subsidiaries of US or UK headquartered companies, is that detailed compliance programmes will need to be instituted. Regulatory...more
My colleagues and I have published an article on unique challenges to mergers and acquisitions involving Federal Government contractors....more
Find a Mergers & Acquisitions Author »


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10:53 am
Wed September 18, 2013
Report Details Spending By Former Arkansas Senator
Documents released by the Arkansas Ethics Commission show that a former state lawmaker who resigned over violations could only identify less than a quarter of the $63,000 his campaign spent as legitimately related to his re-election bid.
The Ethics Commission on Wednesday released the file related to the investigation into former Democratic Sen. Paul Bookout, who stepped down last month after the panel ruled he spent thousands from his campaign on clothing, stereo equipment and other personal items.
The report said that Bookout in June could only identify 5 items totaling $13,964 spent by his campaign as legitimate expenses, but the panel said that $4,000 of that wasn't a proper expense.
The $4,000 was a donation Bookout made to the state Democratic Party.
Ethics Investigation
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Enrollment may fall again in Vancouver
TheVancouver school board is projecting a further decline in enrollment for the 2007-08 school year. "We could lose another 1,000 this year," NPA board chair Ken Denike told the Straight .
Denike said the gentrification of certain neighbourhoods on Vancouver's East Side could partially explain the drop in student population. He cited in particular what's happening in the neighbourhoods near David Thompson , John Oliver , and Sir Charles Tupper secondary schools.
"If you drive through them, there are a lot of new homes there," Denike said. "Who goes into these new homes are often families with very young kids. They're showing up in the elementary schools but not in high schools."
Denike also said that a number of immigrant families with school-age children aren't settling in Vancouver, opting instead for suburban areas where housing is more affordable.
NPA school trustee Carol Gibson told the Straight that if enrollment falls in 2007-08, it would be the second year in a row. "Last year was the first year we've seen such a decline," Gibson said. "The Vancouver school district had predicted its enrollment very accurately up until that point—within one percent."
Enrollment figures for 2006-07 showed a student shortfall of 1,030. There are approximately 56,000 students in the Vancouver public-school system, not including enrollment in adult and continuing education.
Denike and Gibson both said the board is looking at options ranging from the consolidation of programs to the closure of certain schools.
"We're really talking about doing major changes in 2008," Denike said. "We're going out for consultations and get a view of what the public thinks."


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Join FirearmsTalk.com Today - It's Free!
Are you a firearms enthusiast? Then we hope you will join the community. You will gain access to post, create threads, private message, upload images, join groups and more. Firearms Talk is owned and operated by fellow firearms enthusiasts. We strive to offer a non-commercial community to learn and share information.
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Engraving is something I've always sort of wanted to try but never got around to. One of these days I still might try it if I can ever run up on the tools cheap enough.
Sometimes you earthlings REALLY amaze me!
Not me, I'd be too afraid of butchering the firearm. I'll leave mine plane Jane like they come from the factory Your revolver sure looks nice though, congrats!
Member: NRA GOA ΜΟΛΩΝ ΛΑΒΕ Est sularas oth mithas "either way, you were guilty by association, so you were smited...." JD


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Five Dumbest Things on Wall Street: Oct. 17
AIG's Hunting Party
American International Group (AIG - Get Report) may have just gone on the government's dole for $123 billion, but that doesn't mean its executives can't have a jolly old time.
A handful of top executives from AIG allegedly racked up an $86,000 tab during a recent English hunting trip, even as the New York-based insurer was lobbying for an additional $37.8 billion from the Federal Reserve.
AIG spokesman Peter Tulupman said Wednesday that the event had been planned "months before" the Fed's loan to AIG, adding, "We regret that this event was not canceled."
Perhaps sincere regret carries a little less weight in these extraordinary times. What taxpayer wasn't overjoyed with learning that he or she helped sponsor another boondoggle, this one at a $440,000 price tag, for top AIG insurance agents at a posh California resort last month -- just days after the U.S. government stepped in to save AIG with $85 billion? White House Press Secretary Dana Perino called that event "despicable." This latest one, however, we'll call just plain stupid. Dumb-o-meter score: 95 -- Late Thursday, the company declared a moratorium on junkets or perks "not strictly justified by legitimate business neeeds." Tell that to the English big game.Check Out Our Best Services for Investors
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FRWC seeks to add clarity to debate over drinking water
Treatment process, not the Flint River, is source of chemicals in drinking water
Who should win the 2015 Golden Glove Award?
Flint River Watershed Coalition Opposes Rover Pipeline Project
at Federal Scoping Meeting: "Pipeline is Unnecessary."
Rebecca Fedewa, Executive Director of the Flint River Watershed Coalition, delivered comments at the December 10th Federal Energy Regulatory Commission's Environmental Impact Statement Scoping Meeting held at the Holiday Inn Gateway Center in Flint Michigan.
Copies of Fedewa's remarks are available at the following link: 2014.12.10.Fedewa FERC Comments
FRWC Board Passes Resolution Opposing Rover Gas Pipeline.
FERC Certification will grant this company powers of Eminent Domain.
Click here to read our resolution:
2014 October FRWC ET Rover Resolution
Federal Energy Regulatory Commission is taking Public Comment
Make your voice heard in Washington DC!
ET Rover has proposed building a new natural gas pipeline from West Virginia, through Ohio and Michigan before ending near Sarnia, Ontario. They must first secure a certification from the Federal Energy Regulatory Commission. Click on the Comment icon below to learn more about this project, the certification process and how to provide your comments to FERC.
Latest News about our Flint River in
Love the pictures we post here and on Facebook?
We have taken the best of the best and put them into a calendar
so you can enjoy the beauty of the Flint River Watershed all year long!
We have a few copies remaining of our 2014 FRWC Calendar (February 2014 to January 2015) The beautiful pictures featured in this calendar were taken by our members while out recreating or volunteering on our Flint River. The calendar costs $15 and can be picked up or mailed to you.
Contact Jaime Welch at email@example.com or at 810-767-7140 to order yours today.
Flint River Watershed Coalition
Partnering to Protect, Preserve, and Improve the Flint River Watershed.
The Flint River Watershed Coalition is a membership organization that promotes citizen stewardship of our natural resources by providing our members with the sources, knowledge, and capacity necessary to protect local water quality and watershed habitat.
Thank you for supporting our Flint River Watershed!
| FUN on the Flint River!Make 2014 the year you rediscover your Flint River or one of its many beautiful tributaries. See our calendar of events to get involved and have some fun! Email your photos, videos, or stories to firstname.lastname@example.com Share your photos with us on Facebook or YouTube Channel |
What to do with your fish from the Flint River?YES…You can eat your catch.Check out the State of Michigan's Eat Safe Fish website.This site lists safe fish from around the state, including a page on the fish found in the Flint River. | Looking for a gift for a special someone?Get the ones you love the gift of water quality with a membership to the Flint River Watershed Coalition. Contact us here, or click the "Donate Now" button on the left side of the page. We'll send you or your recipient a lovely certificate letting them know they are now a full member of the FRWC. |
// ]]>


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Meet Designer Jeffrey Bilhuber
Lives in: New York, N.Y.
Worked for: Victoria Hagan, Wayne Nathan, Robert Stilin
Opened: Timothy Brown Studio in 2009
Website: timothybrownstudio.com
The dining room reflects his "clean, modern, edited" style. Brown had an "aha" moment when he found a contemporary table with splayed legs like those of midcentury chairs he had bought at auction: marry the two! The lines have an animation that softens the hard lines of the room.
Continue to US Site
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NFLPA asks for restraining order
NEW ORLEANS -- The NFL Players Association has asked a federal judge for a temporary restraining order that would allow players suspended in connection with the NFL's bounty investigation to rejoin their teams in time to play regular season openers.
The union, which filed the motion Tuesday on behalf of New Orleans defensive end Will Smith, Cleveland linebacker Scott Fujita, and free agent defensive lineman Anthony Hargrove, argues the players will suffer irreparable harm if they are forced to miss games while their case against the league proceeds.
More from ESPN Radio
In this clip from the Football Today podcast, Ross Tucker and Matt Williamson preview the Cowboys and Giants. Listen
Suspended Saints linebacker Jonathan Vilma had already filed a similar motion when his full-season suspension began earlier. The other three players' suspensions began this week.
The players ultimately want their suspensions thrown out because they argue the disciplinary process was fundamentally flawed and unfair.
U.S. District Judge Ginger Berrigan, who is hearing the case, has said she found the league's handling of the bounty matter to be unfair to the players and their punishments excessive, but she has also said she is not yet comfortable that federal courts have jurisdiction to rule on a process that was collectively bargained between the union and the league.
She has already indicated, in response to Vilma's earlier request for a temporary restraining order, that she was inclined to wait until players had exhausted their remedies under the league's collective bargaining agreement before she ruled.
Still pending on that front is a decision by a three-member panel that last week heard arguments in the NFLPA's appeal of a system arbitrator Stephen Burbank's ruling that commissioner Roger Goodell had the authority both to punish the players and hear their appeal in the bounty matter.
The union had argued that because actions alleged in the bounty matter happened on the field, the league's labor agreement calls for someone other than the commissioner to hear players' appeals of the commissioner's disciplinary action.
Saints Bounty Scandal
An NFL investigation found the New Orleans Saints operated a bounty system that rewarded 22 to 27 players for hard hits and for injuring opposing players. Profile »
The three-member panel has indicated that it hoped to rule by this week. If it rules in favor of the players, Berrigan would have no reason to act.
The NFL has said its investigators have concluded that the Saints ran a bounty program from the 2009 through 2011 seasons. The league said the program offered improper cash bonuses to defensive players for hits that injured opponents.
The players have admitted to a pay-for-performance program for big plays such as turnovers and big, clean hits, which also is banned but cannot be punished by suspensions. However, they have denied, some under oath in federal court, that there was a pay-to-injure program.
In addition to the four players suspended, the league also suspended Saints head coach Sean Payton the entire season, Saints general manager Mickey Loomis for half the season, and Saints assistant head coach Joe Vitt for six games. Former Saints defensive coordinator Gregg Williams, who is now with St. Louis and allegedly administered the bounty pool, has been suspended indefinitely.
Copyright 2012 by The Associated Press
- Kraft expects apology if NFL can't find culprit
- Report: NFL eyes Pats locker room attendant
- Browner's targeting plans sadden Seahawks
- Pro Bowlers: Arizona missing vibes of Hawaii
The NFL on ESPN.com
- Follow the NFL on ESPN on Facebook
- Fantasy Football on ESPN.com | Play
- NFL preview home | NFL Nation blog
- Fox: 49ers determined to reach goals
- Clayton: Packers, Patriots take it easy
- Schefter's 10 Spot: Rookie QBs ready?
- Story: Players' punishment lifted
- Bryant: Vilma's fight for his name
- Chadiha: Players' win a gut punch to Goodell
- Brandt: Ruling a blow to Goodell's power
- SportsNation: The right move?
- Ranks: Scouts top 150 | Kiper Big Board
- McShay: Top 150 numbers and trends
- McShay: Week 2 matchups to watch
- Kiper's top 5s: Seniors | Juniors
- Cheat Sheets: QBs | RBs | TEs | WRs | OL
- Defensive Cheat Sheets: DL | LBs | DBs
- Sprow: Packers have top WR/TE group
- Polian: Which rookie QBs can win now?
- Edwards: How Vontae Davis helps Colts
- Joyner: A rookie QB revolution is upon us
- Photo gallery: Art Modell
- Clayton: Modell was mostly a model owner
- Chadiha: Meet The Indispensables
- Double Coverage: Pats-Titans breakdown
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- Outsiders: Week 1 Upset Watch
- Joyner: Packers' D will take huge leap
- Hensley: Big Ben aims for 'elite' club
- MVP Watch: Rodgers a shoo-in?
- Rookie Watch: Why Luck is special
- Hill: A less fun NFL kickoff
- Scouts Inc.: Week 1 previews
- Seifert: Packers focused on four key stats
Who has the #1 spot this week? Jersey Report »
- Williamson: Ranking 32 NFL 'farm systems'
- Yates: How the Patriots were built
- Sando: Ranking the head coach hires
- Kiper: Regrading the 2014 NFL draft
- Insider: Offseason plans for every team


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Hughton Looks Forward
Chris Hughton said on Saturday ... "We are back where this club wanted to be. Chris Hughton: "We are back where this club wanted to be. "We know, of course, it will be a very tough season because we are in a very, very tough league. "You have to look forward to it. As a manager, as a group of players, as a club, it's where we want to be and we have worked very hard for it, so you have to look forward to it."
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Publications (250)1393.34 Total impact
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ABSTRACT: A number of N-alkylated polyethylenimines (PEIs) were covalently attached to glass-slide surfaces, and their virucidal efficacies against three different strains of influenza viruses were examined quantitatively. The anti-influenza activities of the modified surfaces varied widely, with the most potent, immobilized N,N-hexyl,methyl-PEI and N,N-dodecyl,methyl-PEI, reducing the viral titer by over three logs (i.e., > 99.9%). While the virucidal activities of the glass surfaces derivatized with N-alkylated PEIs displayed no discernible correlation with such surface properties as hydrophobicity, charge, protein affinity, roughness, adhesive interactions, and polymer-chain extension lengths, they exhibited a marginal correlation with the surface density of quaternary ammonium group as titrated by means of fluorescein binding. However, this correlation markedly improved (to the correlation coefficient of 0.97 with a two-tailed p value of 0.044) when the titration was instead carried out using a macromolecular conjugate, the dye coupled to the protein lysozyme, suggesting that the critical determinant of the virucidal activity is the density of the immobilized quaternary ammonium groups accessible to influenza virions.Biomacromolecules 12/2014; · 5.79 Impact Factor -
Article: Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial.
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ABSTRACT: The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N,N-hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli, and virucidal against human influenza virus.Applied biochemistry and biotechnology 10/2013; · 1.94 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Previously, polymer-attached zanamivir had been found to inhibit influenza A viruses in vitro far better than did small-molecule zanamivir (1) itself. The aim of this study was to identify in vitro-using the plaque reduction assay-a highly potent 1-polymer conjugate, and subsequently test its antiviral efficacy in vivo. By examining the structure-activity relationship of 1-polymer conjugates in the plaque assay, we have determined that the most potent inhibitor against several representative influenza virus strains has a neutral high-molecular-weight backbone and a short alkyl linker. We have examined this optimal polymeric inhibitor for efficacy and immunogenicity in the mouse and ferret models of infection. 1 attached to poly-L-glutamine is an effective therapeutic for established influenza infection in ferrets, reducing viral titers up to 30-fold for 6 days. There is also up to a 190-fold reduction in viral load when the drug is used as a combined prophylactic/therapeutic in mice. Additionally, we see no evidence that the drug conjugate stimulates an immune response in mice upon repeat administration. 1 attached to a neutral high-molecular-weight backbone through a short alkyl linker drastically reduced both in vitro and in vivo titers compared to those observed with 1 itself. Thus, further development of this polymeric zanamivir for the mitigation of influenza infection seems warranted.Pharmaceutical Research 09/2013; · 4.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: By attaching multiple copies of the influenza M2 ion channel inhibitors amantadine (1) and rimantadine (2) to polymeric chains, we endeavored to recover their potency in inhibiting drug-resistant influenza viruses. Depending on loading densities, as well as the nature of the drug, the polymer, and the spacer arm, polymer-conjugated drugs were up to 30-fold more potent inhibitors of drug-resistant strains than their monomeric parents. In particular, a 20% loading density and a short linker group on the negatively charged poly-l-glutamate resulted in one of the most potent inhibitors for 2's conjugates against drug-resistant influenza strains. Although full recovery of the inhibitory action against drug-resistant strains was not achieved, this study may be a step toward salvaging anti-influenza drugs that are no longer effective. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.Journal of Pharmaceutical Sciences 07/2013; · 3.13 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: This study examined the effects of BMP7 gene transfer on corneal wound healing and fibrosis inhibition in vivo using a rabbit model. Corneal haze in rabbits was produced with the excimer laser performing -9 diopters photorefractive keratectomy. BMP7 gene was introduced into rabbit keratocytes by polyethylimine-conjugated gold nanoparticles (PEI2-GNPs) transfection solution single 5-minute topical application on the eye. Corneal haze and ocular health in live animals was gauged with stereo- and slit-lamp biomicroscopy. The levels of fibrosis [α-smooth muscle actin (αSMA), F-actin and fibronectin], immune reaction (CD11b and F4/80), keratocyte apoptosis (TUNEL), calcification (alizarin red, vonKossa and osteocalcin), and delivered-BMP7 gene expression in corneal tissues were quantified with immunofluorescence, western blotting and/or real-time PCR. Human corneal fibroblasts (HCF) and in vitro experiments were used to characterize the molecular mechanism mediating BMP7's anti-fibrosis effects. PEI2-GNPs showed substantial BMP7 gene delivery into rabbit keratocytes in vivo (2×10(4) gene copies/ug DNA). Localized BMP7 gene therapy showed a significant corneal haze decrease (1.68±0.31 compared to 3.2±0.43 in control corneas; p<0.05) in Fantes grading scale. Immunostaining and immunoblot analyses detected significantly reduced levels of αSMA (46±5% p<0.001) and fibronectin proteins (48±5% p<0.01). TUNEL, CD11b, and F4/80 assays revealed that BMP7 gene therapy is nonimmunogenic and nontoxic for the cornea. Furthermore, alizarin red, vonKossa and osteocalcin analyses revealed that localized PEI2-GNP-mediated BMP7 gene transfer in rabbit cornea does not cause calcification or osteoblast recruitment. Immunofluorescence of BMP7-transefected HCFs showed significantly increased pSmad-1/5/8 nuclear localization (>88%; p<0.0001), and immunoblotting of BMP7-transefected HCFs grown in the presence of TGFβ demonstrated significantly enhanced pSmad-1/5/8 (95%; p<0.001) and Smad6 (53%, p<0.001), and decreased αSMA (78%; p<0.001) protein levels. These results suggest that localized BMP7 gene delivery in rabbit cornea modulates wound healing and inhibits fibrosis in vivo by counter balancing TGFβ1-mediated profibrotic Smad signaling.PLoS ONE 06/2013; 8(6):e66434. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: The aim of this study was to markedly lower the viscosities of highly concentrated protein, in particular antibody, formulations. An effective approach elaborated herein for γ-globulin and a monoclonal antibody is to replace aqueous solutions with equimolar suspensions in neat organic solvents. METHODS: Viscosities of aqueous solutions and non-aqueous suspensions of the model protein bovine γ-globulin and a murine monoclonal antibody were examined under a variety of experimental conditions. In addition, protein particle sizes were measured using dynamic light scattering and light microscopy. RESULTS: Concentrated suspensions of amorphous γ-globulin powders (up to 300 mg/mL, composed of multi-micron-sized particles) in absolute ethanol and a number of other organic solvents were found to have viscosities up to 38 times lower than the corresponding aqueous solutions. Monoclonal antibody follows the same general trend. Additionally, the higher the protein concentration and lower the temperature, the greater the viscosity benefit of a suspension over a solution. CONCLUSIONS: The viscosities of concentrated γ-globulin and monoclonal antibody suspensions in organic solvents are drastically reduced compared to the corresponding aqueous solutions; the magnitude of this reduction depends on the solvent, particularly its hydrogen-bonding properties.Pharmaceutical Research 03/2013; · 4.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The infectivity of high-titer, cell-free HIV in culture media and human milk is rapidly reduced upon exposure to polyethylene slides painted with the linear hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI). Accompanying viral p24 protein and free viral RNA analysis of solutions exposed to DMPEI-coated surfaces suggest that virion attachment to the polycationic surface and its subsequent inactivation are the likely mechanism of this phenomenon. Biotechnol. Bioeng. © 2013 Wiley Periodicals, Inc.Biotechnology and Bioengineering 02/2013; · 4.16 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, as well as inactivate the enveloped influenza virus (but not the non-enveloped poliovirus).Applied biochemistry and biotechnology 01/2013; · 1.94 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Many consumer goods must be protected from bacterial and fungal colonization to ensure their integrity and safety. By making these items' packaging biocidal, the interior environment can be preserved from microbial spoilage without altering the products themselves. Herein we briefly review this concept, referred to as active packaging, and discuss existing methods for constructing active packaging systems. They are based on either packaging materials that release biocides or those that are themselves intrinsically biocidal (or biostatic), with numerous variations within each category.Annual Review of Chemical and Biomolecular Engineering 01/2013; 4:171-86. · 8.11 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Covalently conjugating multiple copies of the drug zanamivir (ZA; the active ingredient in Relenza) via a flexible linker to poly-L-glutamine (PGN) enhances the anti-influenza virus activity by orders of magnitude. In this study, we investigated the mechanisms of this phenomenon. Like ZA itself, the PGN-attached drug (PGN-ZA) binds specifically to viral neuraminidase and inhibits both its enzymatic activity and the release of newly synthesized virions from infected cells. Unlike monomeric ZA, however, PGN-ZA also synergistically inhibits early stages of influenza virus infection, thus contributing to the markedly increased antiviral potency. This inhibition is not caused by a direct virucidal effect, aggregation of viruses, or inhibition of viral attachment to target cells and the subsequent endocytosis; rather, it is a result of interference with intracellular trafficking of the endocytosed viruses and the subsequent virus-endosome fusion. These findings both rationalize the great anti-influenza potency of PGN-ZA and reveal that attaching ZA to a polymeric chain confers a unique mechanism of antiviral action potentially useful for minimizing drug resistance.Proceedings of the National Academy of Sciences 11/2012; · 9.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The utility of plasmid DNA as an immunogen has been limited by its weak immunogenicity. In the present study, we evaluated the ability of a family of linear polyethylenimine (PEI) polymers, complexed to plasmid DNA, to augment DNA expression in vivo and to enhance antigen-specific adaptive immune responses. We showed that four of five structurally different PEIs that we evaluated increased in vivo DNA expression 20- to 400-fold, and enhanced DNA-induced epitope-specific CD8+ T-cell responses 10- to 25-fold in BALB/c and C57BL/6J mice respectively, when delivered intravenously. Functional studies of the PEI-DNA-induced CD8+ T-cell responses demonstrated that formulation of DNA with PEI was associated with increased numbers of cells secreting type I cytokines. In addition, PEI-DNA complexes improved antigen-specific T(H) 1-helper cell and humoral responses. Most importantly, the PEI-DNA complexes elicited memory cellular responses, capable of rapid expansion and accelerated clearance of a lethal dose of recombinant Listeria monocytogenes. Lastly, we identified physical properties of PEI-DNA complexes that are associated with enhanced DNA-elicited immunogenicity. These findings demonstrate that PEI polymers can play an important role in the development of DNA-based vaccines in the setting of infectious disease prevention and cancer therapy.European Journal of Immunology 08/2012; · 4.52 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: PURPOSE: To explore surface-immobilized and suspended modalities of the hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI) for the ability to reduce viral infectivity in aqueous solutions containing herpes simplex viruses (HSVs) 1 and 2. METHODS: Surface-immobilized (coated onto surfaces) and suspended DMPEI were incubated with aqueous solutions containing HSV-1 or -2 to measure the antiviral effect of the hydrophobic polycation's formulations on HSVs. RESULTS: DMPEI coated on either polyethylene slides or male latex condoms dramatically decreases infectivity in solutions containing HSV-1 or -2. Moreover, DMPEI suspended in aqueous solution markedly reduces the infectious titer of these HSVs. CONCLUSION: Our results suggest potential uses of DMPEI for both prophylaxis (in the form of coated condoms) and treatment (as a topical suspension) for HSV infections.Pharmaceutical Research 07/2012; · 4.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Using the plaque reduction assay, relatively simple bicyclic quinone molecules, as well as multiple copies thereof covalently attached to a long polyglutamate-based polymeric chain, were examined as new inhibitors of various naturally occurring strains of influenza A virus. The polymer-conjugated inhibitors were found to have a far greater potency (for some as high as two orders of magnitude when a long spacer arm was employed) than their corresponding parent molecules against the human Wuhan influenza strain. However, such polymeric inhibitors failed to exhibit higher potency compared with their small molecule predecessors against the human Puerto Rico and avian turkey influenza strains. These observations, further explored by means of molecular modeling, reveal the previously unrecognized unpredictability of the benefits of multivalency, possibly because of poor accessibility of the viral targets to polymeric agents.Journal of Pharmaceutical Sciences 07/2012; 101(10):3896-905. · 3.13 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To discover, elucidate the structure-activity relationship (SAR), and explore the mechanism of action of excipients able to drastically lower the viscosities of concentrated aqueous solutions of humanized monoclonal antibodies (MAbs). Salts prepared from hydrophobic cations and anions were dissolved into humanized MAbs solutions. Viscosities of the resulting solutions were measured as a function of the nature and concentration of the salts and MAbs. Even at moderate concentrations, some of the salts prepared herein were found to reduce over 10-fold the viscosities of concentrated aqueous solutions of several MAbs at room temperature. To be potent viscosity-lowering excipients, the ionic constituents of the salts must be hydrophobic, bulky, and aliphatic. A mechanistic hypothesis explaining the observed salt effects on MAb solutions' viscosities was proposed and verified.Pharmaceutical Research 06/2012; 29(11):3102-9. · 4.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Polyelectrolyte multilayer films assembled from a hydrophobic N-alkylated polyethylenimine and a hydrophilic polyacrylate were discovered to exhibit strong antifouling, as well as antimicrobial, activities. Surfaces coated with these layer-by-layer (LbL) films, which range from 6 to 10 bilayers (up to 45 nm in thickness), adsorbed up to 20 times less protein from blood plasma than the uncoated controls. The dependence of the antifouling activity on the nature of the polycation, as well as on assembly conditions and the number of layers in the LbL films, was investigated. Changing the hydrophobicity of the polycation altered the surface composition and the resistance to protein adsorption of the LbL films. Importantly, this resistance was greater for coated surfaces with the polyanion on top; for these films, the average zeta potential pointed to a near neutral surface charge, thus, presumably minimizing their electrostatic interactions with the protein. The film surface exhibited a large contact angle hysteresis, indicating a heterogeneous topology likely due to the existence of hydrophobic-hydrophilic regions on the surface. Scanning electron micrographs of the film surface revealed the existence of nanoscale domains. We hypothesize that the existence of hydrophobic/hydrophilic nanodomains, as well as surface charge neutrality, contributes to the LbL film's resistance to protein adsorption.Biomacromolecules 02/2012; 13(3):719-26. · 5.79 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To explore (i) the potential of polyethylenimine (PEI)-DNA nanoparticles as a vector for delivering genes into human corneal fibroblasts, and (ii) whether the nanoparticle-mediated soluble extracellular domain of the transforming growth factor-β type II receptor (sTGFβRII) gene therapy could be used to reduce myofibroblasts and fibrosis in the cornea using an in vitro model. PEI-DNA nanoparticles were prepared at a nitrogen-to-phosphate ratio of 30 by mixing linear PEI and a plasmid encoding sTGFβRII conjugated to the fragment crystallizable (Fc) portion of human immunoglobulin. The PEI-DNA polyplex formation was confirmed through gel retardation assay. Human corneal fibroblasts (HCFs) were generated from donor corneas; myofibroblasts and fibrosis were induced with TGFβ1 (1 ng/ml) stimulation employing serum-free conditions. The sTGFβRII conjugated to the Fc portion of human immunoglobulin gene was introduced into HCF using either PEI-DNA nanoparticles or Lipofectamine. Suitable negative and positive controls to compare selected nanoparticle and therapeutic gene efficiency were included. Delivered gene copies and mRNA (mRNA) expression were quantified with real-time quantitative PCR (qPCR) and protein with enzyme-linked immunosorbent assay (ELISA). The changes in fibrosis parameters were quantified by measuring fibrosis marker α-smooth muscle actin (SMA) mRNA and protein levels with qPCR, immunostaining, and immunoblotting. Cytotoxicity was determined using cellular viability, proliferation, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. PEI readily bound to plasmids to form nanoparticular polyplexes and exhibited much greater transfection efficiency (p<0.01) than the commercial reagent Lipofectamine. The PEI-DNA-treated cultures showed 4.5×10(4) plasmid copies/µg DNA in real-time qPCR and 7,030±87 pg/ml sTGFβRII protein in ELISA analyses, whereas Lipofectamine-transfected cultures demonstrated 1.9×10(3) gene copies/µg DNA and 1,640±100 pg/ml sTGFβRII protein during these assays. The PEI-mediated sTGFβRII delivery remarkably attenuated TGFβ1-induced transdifferentiation of corneal fibroblasts to myofibroblasts in cultures, as indicated by threefold lower levels of SMA mRNA (p<0.01) and significant inhibition of SMA protein (up to 96±3%; p<0.001 compared to no-gene-delivered cultures) in immunocytochemical staining and immunoblotting. The nanoparticle-mediated delivery of sTGFβRII showed significantly better antifibrotic effects than the Lipofectamine under similar experimental conditions. However, the inhibition of myofibroblast in HCF cultures by sTGFβRII overexpression by either method was significantly higher than the naked vector transfection. Furthermore, PEI- or Lipofectamine-mediated sTGFβRII delivery into HCF did not alter cellular proliferation or phenotype at 12 and 24 h post-treatment. Nanoparticles treated with HCF showed more than 90% cellular viability and very low cell death (2-6 TUNEL+ cells), suggesting that the tested doses of PEI-nanoparticles do not induce significant cell death. This study demonstrated that PEI-DNA nanoparticles are an attractive vector for the development of nonviral corneal gene therapy approaches and that the sTGFβRII gene delivery into keratocytes could be used to control corneal fibrosis in vivo.Molecular vision 01/2012; 18:2598-607. · 2.25 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Heparin covalently attached to a water-insoluble resin suspended in HIV-infected aqueous buffer or whole blood captures the virus; subsequent physical separation of the immobilized heparin reduced the viral titers by over 80 and 50%, respectively. The detoxification concept has been validated by both circulating an HIV-1 solution through a column packed with the heparin-sepharose beads and successively mixing an HIV-1 solution with fresh beads.Biotechnology Letters 12/2011; 34(5):853-6. · 1.74 Impact Factor -
Article: Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection.
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ABSTRACT: Adhesion of microorganisms to biomaterials with subsequent formation of biofilms on such foreign bodies as orthopedic trauma hardware is a critical factor in implant-associated infections; once a biofilm has been established, its microorganisms become recalcitrant to the host's immune surveillance and markedly resistant to drugs. We have previously reported that painting with the hydrophobic polycation N,N-dodecyl,methyl-PEI (PEI = polyethylenimine) renders solid surfaces bactericidal in vitro. Herein we observe that N,N-dodecyl,methyl-PEI-derivatized titanium and stainless steel surfaces resist biofilm formation by Staphylococcus aureus compared to the untreated ones. Using imaging, microbiology-, histopathology-, and scanning electron microscopy (SEM) experiments in a clinically relevant large-animal (sheep) trauma model, we subsequently demonstrate in vivo that orthopedic fracture hardware painted with N,N-dodecyl,methyl-PEI not only prevents implant colonization with biofilm but also promotes bone healing. Functionalizing orthopedic hardware with hydrophobic polycations thus holds promise in supporting bone healing in the presence of infection in veterinary and human orthopedic patients.Biomaterials 11/2011; 33(5):1245-54. · 8.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, we observed that HMPEI-derivatized materials exert an inhibitory effect on biofilm formation by Staphylococcus aureus clinical isolates, as compared to the parent poly(methyl methacrylate) (PMMA) and titanium. There was no additional corneal epithelial cell cytotoxicity of HMPEI-coated PMMA compared to that of control PMMA in tissue cultures in vitro. Likewise, no toxicity or adverse reactivity was detected with HMPEI-derivatized PMMA or titanium compared to those of the control materials after intrastromal or anterior chamber implantation in rabbits in vivo.Biomaterials 09/2011; 32(34):8783-96. · 8.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Mercury ions (Hg(2+)) are a highly toxic and ubiquitous pollutants requiring rapid and sensitive on-site detection methods in the environment and foods. Herein, we report an envanescent wave DNA-based biosensor for rapid and very sensitive Hg(2+) detection based on a direct structure-competitive detection mode. In this system, a DNA probe covalently immobilized onto a fiber optic sensor contains a short common oligonucleotide sequences that can hybidize with a fluorescently labeled complementary DNA. The DNA probe also comprises a sequence of T-T mismatch pairs that binds with Hg(2+) to form a T-Hg(2+)-T complex by folding of the DNA segments into a hairpin structure. With a structure-competitive mode, a higher concentration of Hg(2+) leads to less fluorescence-labeled cDNA bound to the sensor surface and thus to lower fluorescence signal. The total analysis time for a single sample, including the measurement and surface regeneration, was under 6 min with a Hg(2+) detection limit of 2.1 nM. The high specificity of the sensor was demonstrated by evaluating its response to a number of potentially interfering metal ions. The sensor's surface can be regenerated with a 0.5% SDS solution (pH 1.9) over 100 times with no significant deterioration of performance. This platform is potentially applicable to detect other heavy metal ions or small-molecule analytes for which DNA/aptamers can be used as specific sensing probes.Biosensors & Bioelectronics 06/2011; 26(10):4018-23. · 6.45 Impact Factor
Publication Stats
13k | Citations | |
1,393.34 | Total Impact Points | |
Top Journals
University of Missouri
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Columbia, Missouri, United States
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- • Department of Chemical Engineering
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Massachusetts Eye and Ear Infirmary
- Department of Ophthalmology
Boston, MA, United States -
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Philadelphia, PA, United States
University of Seoul
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Northeastern University
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Boston, MA, United States


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Critics Slam Jail-Like Atmosphere After Death of 11-Year-Old in Hyderabad Juvenile Home
India | Written by Uma Sudhir | Saturday January 24, 2015
The superintendent and supervisor of a government-run juvenile home in Hyderabad, where an 11-year-old was found dead in a mysterious condition this week, have been suspended. Police say that preliminary investigation point to negligence on their par...
13 Child Labourers Rescued From Cuttack
Cities | Press Trust of India | Thursday November 27, 2014
Thirteen child labourers, engaged in hotels, liquor shops and construction sites, were rescued by the Cuttack district Child Welfare Committee (CWC) with the help of police, a CWC member said today.
Jalpaiguri: Woman Takes Back Son After Selling Him for Rs 13000
Cities | Written by Monideepa Banerjie | Thursday June 12, 2014
The woman in West Bengal's Jalpaiguri who had sold her new born son for 13,000 rupees last month has now taken him back.
Trafficking: 59 Children from West Bengal to be Sent Home
India | Press Trust of India | Wednesday June 11, 2014
More than 100 children from Jharkhand, brought for orphanages in Kerala without proper documents recently, were sent back home while 59 boys from West Bengal would be returned to their home state in the next two days, state government said on Tuesday...
Aizawl: Mizo Boy, Missing for Five Years, Rescued From Haryana
Cities | Press Trust of India | Monday May 26, 2014
A 14-year-old Mizo boy, who was taken away from his poor parents by some people promising better life five years ago, was rescued from an ashram in Haryana, Mizoram Child Welfare Committee said today.
Delhi: Child Welfare Committee Formed for Rehabilitation of Fire Victims
Cities | Press Trust of India | Monday May 12, 2014
To facilitate expeditious decisions regarding care and protection of neglected children the Delhi government has constituted a new Child Welfare Committee at Lajpat Nagar, for the rehabilitation of fire victim boys and girls.
For fourth day, Kerala child in coma; father jailed for attempt to murder
India | Reported by Sneha Mary Koshy, Edited by Deepshikha Ghosh | Thursday July 18, 2013
Beaten mercilessly and tortured by his own parents, a five-year-old child is battling for life in a Kerala hospital, lying in coma, with extensive damage to his brain and lungs and horrifying injuries all over his body.
Three arrested in Delhi for alleged human trafficking, 20 girls rescued: Police
Cities | Press Trust of India | Sunday June 16, 2013
Police have arrested three people in Ghaziabad today for allegedly trafficking girls from Jharkhand to Delhi. The cops also claimed to have rescued about 20 girls from a railway station.
Over 2,150 rape cases in Karnataka in three years: House panel
South | Press Trust of India | Friday June 7, 2013
More than 2,150 rape cases were registered in Karnataka in the past three years, says a report of an official committee, calling for the need for non-bailable warrant against accused and bringing the crime under the stringent Goonda Act.
Norway custody row: After eight months, mother gets custody of children
India | Edited by Prasad Sanyal | Tuesday January 8, 2013
Eight months after her children returned to India after a lengthy legal battle in Norway, Sagarika Bhattacharya will be able to take them home. The 30-year-old had been granted custody of her son Abhigyan and her daughter Aishwarya by the Calcutta Hi...
Three-year-old raped by father, abandoned by mother, struggles for survival
Cities | Mid-Day.com | Friday December 21, 2012
On November 25, a brave 19-year-old girl caught her neighbour in the act of raping his three-year-old daughter, and rescued the child. Since then, the only family known to Asha (name changed to protect privacy) as she inches towards a recovery, are d...
Child Welfare Committee's press release on its order
India | ndtv.com | Friday November 9, 2012
The Child Welfare Committee of Burdwan (CWC) has passed interim orders for release of the siblings Abhigyan Bhattacharya (4 yrs) and Aishwarya Bhattacharya (23 months) from foster care and restoration to their mother, Smt. Sagarika Chakraborty.
Why India's helping this rickshaw puller's baby
Cities | Reported by Harsha Kumari Singh; Edited by Shamik Ghosh | Monday October 22, 2012
One-month old Damini is still in critical condition in hospital. But Baby Damini, who till two days ago was strapped by her father to his chest as he pulled a rickshaw in Rajasthan, now has a whole country looking after her.
Pune cops asks 15-year-old to get back with her husband
Cities | Mid-Day.com | Friday June 29, 2012
Officials of the Dehu Road police station have come under heavy criticism for allegedly turning down a 15-year-old's plea to register a complaint of domestic violence against her husband and in-laws. In addition, they allegedly asked the girl to go b...
NRI in Sweden claims son being held in foster care
India | Press Trust of India | Wednesday May 2, 2012
Close on the heels of the Norway child custody row, a similar case has come to light in Sweden where an NRI woman has claimed that her son is being held in foster care on charges of neglect and sought the help from Indian authorities.
Baby Afreen's grandmother summoned by State Welfare Committee
South | NDTV Correspondent | Wednesday April 11, 2012
Even as baby Afreen continues to be on life support in the ICU of a Bangalore hospital, after allegedly being beaten by her own father, the state Child Welfare Committee has issued a notice to the paternal grandmother of baby Afreen. The committee is...
'Baby bazaar' gets minister's attention
Cities | MiD-Day.com | Tuesday February 21, 2012
A day after MiD DAY's expose on the baby-selling racket flourishing in Ulhasnagar, even as Minister of Women and Child Welfare assured of necessary action in the matter, members of the Child Welfare Committee (CWC) called for an emergency meet at NGO...
36 children disappear mysteriously from Pune orphanage
Cities | Mid-Day.com | Friday June 17, 2011
Thirty-six children between the age of one to 18 have disappeared from the Niradhar Balsangopan Anath Ashram in Dapodi in Pune. The incident took place just two days after the Dnyanadevi-Childline social workers found all 36 children eating together in a single room on the ground floor of the two-st...


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Newest release of open source suite comes as LibreOffice now claims 80 million active users around the world.
Technically Incorrect: The famous artiste says she dropped her iPhone in the toilet, dried it in rice and then...
A project by Australia's MS Society gives an inside look at what it's like living with the disease.
Microsoft is looking for love, your love, and it might just get it. Also, SpaceX CEO Elon Musk gets more money, and BlackBerry CEO John Chen makes a ridiculous request. All that and more in this look back at the week in tech.
Windows 10 on smartphones will look a little cleaner and behave a little better than before, but the biggest changes Microsoft made to its all-in-one OS come from the phone, not the other way around.
The Internet Archive has released a library of 2,314 classic MS-DOS games that you can download and play for free in a browser-based emulator.
An entity called Google Compare Auto Insurance Services is now licensed to do business in more than half the US, an analyst finds.
Big subs have huge advanatages over compact subs, so yet again the lesson is clear: for the best sound quality, size matters!
The software giant is trying to crack down on scammers that allegedly took advantage of consumers by claiming their PCs were infected with malware.
AV receivers are embarrassingly backward compared with the rest of your home theater gear. Here's how they can get back on track.


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CEU3215 Herbalism Professional Series Online-Herbs & Health
PAYMENT for your course(s) IS DUE WHEN YOU REGISTER. Register and pay online or by phone: 971-722-8888.
DROP/REFUND POLICY: You must drop a course at least one day before the class begins to receive a refund.
Course meets online 2-4pm PST (office hours online 4:30-5:30pm) or 5:30-7:30pm PST (office hours online 8-9pm). The Herbs and Health Module will include the study of specific herb properties, Ayurvedic and Chinese herbalism, the Respiratory, Urinary and Nervous systems, Preparations, Plant Chemistry, and Integrated Healing: Vitamins and Minerals. Extensive electronic materials provided. Texts required. View the Term Booklist at: http://www.pcc.edu/climb/health/documents/book-list-winter.pdf
PREPARE FOR THE FIRST CLASS. ONCE REGISTERED, STUDENTS MUST ACCESS THEIR PCC EMAIL ADDRESS. For directions as to how to login into your email account, please go to https://my.pcc.edu/cp/home/displaylogin or, contact Help Desk at 503-977-8200. Instructions to access online classes will be sent to registered students prior to class start.
Online courses require that students have basic to intermediate computer savvy, and are skilled in personal discipline, task organization and time management. Students should expect to invest a minimum of 2-3 hours of study time for every hour of lecture in order to be successful in this course.
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CRN | Campus / Bldg / Rm | Time | Days | Dates | |
13629 | Distance Learning / DST / TBA | 02:00 PM-04:00 PM | W | 07-Jan-2015 thru 25-Mar-2015 | |
Instructor: Karta Purkh S Khalsa
Notes: Lecture times: 2p or 5:30p student can attend either lecture Tuition: $899.00 Fees: $0.00 |
and | Distance Learning / DST / TBA | 05:30 PM-07:30 PM | W | 07-Jan-2015 thru 25-Mar-2015 | |
Instructor: Karta Purkh S Khalsa


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How can I disable php combobox's default option?
I'm in a bit of a quandary of this small snippet of code I'm trying to modify. It's not my code, by the way Anyway, this code works in a combo-box and here's the scenario that's giving me problems.
The default value in the box is simply text that outputs "[Archive]". When a user selects one of the valid entries the page is correctly redirect to a dynamic php page with the URL populated by the unique ID of whatever their selection was. However! - and this is the problem - if after making a selection, being redirected to the page the user clicks the back button in the browser taking them back to the page with the combo box; if they make the selection of the "[Archive]" value, they are then redirected to a page (as specified in the code) but with a "blank" ID in the URL.
All I want to do is make it so that if the user does click "back" and (un)intentionally selects "[Archive]" they're not redirected anywhere.
Here's the code that's at work (as far as I can tell):
Code:<?php class ccm_archive { var $DB_PREFIX; var $_db; var $_config; var $_common; function ccm_archive($db,$dbConfig,$config,$common) { $this->_db = $db; $this->DB_PREFIX = &$dbConfig->prefix; $this->_config = &$config; $this->_common = $common; } function listComicsSelectBox($showIDs='', $reverse='', $storylines='') { $order = (empty($reverse)) ? 'ASC' : 'DESC'; $result = $this->_db->Execute("SELECT id,date,comic_title,storyline FROM {$this->DB_PREFIX}comic WHERE live='1' ORDER BY date $order"); $r = '<select name="comicID" onchange="location.href=\'' .$this->_config->archive_comic_url."?comicID='+value;\">"; $r .= '<option value="">[Archives]</option>'; while (!$result->EOF) { list ($id,$date,$title,$sl) = $result->fields; $indent = (!empty($storylines) && (!empty($sl))) ? ' ' : ''; $r .= "<option value=\"$id\">"; $r .= (empty($showIDs)) ? "$indent $title" : "$indent [$id] $title"; $r .= "</option>"; $result->MoveNext(); } $r .= '</select>'; return $r; } } $ccm_archive = new ccm_archive(&$ccm_db,&$ccm_dbConfig,&$ccm_config,&$ccm_common); ?>
Thanks for your help everyone!
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toPHP Code:
$r = '<select name="comicID" onchange="location.href=\''
PHP Code:
$r = '<select name="comicID" onchange="if(this.value != \'\') location.href=\''
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Nick Jonas is sick of 'looking at himself' grabbing his crotch by Christina Marfice 3 days ago Share Tweet Pin Share Save As if we needed any more proof that Nick Jonas has left his Disney days completely behind him. Read Full Story
2014's Most charitable celeb isn't a surprise at all by Christina Marfice Dec 30, 2014 Share Tweet Pin Share Save This should come as a surprise to no one. Read Full Story
Demi Lovato reveals five other celebrities who kept her from relapsing by Caroline Goddard Dec 05, 2014 Share Tweet Pin Share Save Demi Lovato knows that maintaining her health is a daily battle — but she has some surprising celebrity inspiration to keep her on track. Read Full Story
'Demi Lovato Fatty:' Fan claims Lovato called her fat, bullied her by Sarah Long Dec 04, 2014 Share Tweet Pin Share Save Demi Lovato is facing some very, very bizarre accusations. Read Full Story
6 Times Demi Lovato and Wilmer Valderrama showed PDA on social media by Sarah Long Nov 18, 2014 Share Tweet Pin Share Save Are Wilmer Valderrama and Demi Lovato the sweetest celeb couple ever? All social media signs are pointing to yes! Read Full Story
Demi Lovato puts Meghan Trainor on blast for her eating disorder comments by Cailyn Cox Nov 14, 2014 Share Tweet Pin Share Save Demi Lovato wants the world to know that eating disorders are no joke — and that applies to you, too, Meghan Trainor. Read Full Story
12 Celebs who surprisingly believe in aliens by Tiffany Antone Nov 07, 2014 Share Tweet Pin Share Save SheKnows got to sit down with Eddie Redmayne and Felicity Jones, stars of the upcoming Stephen Hawking biopic The Theory of Everything, and we asked what they thought of Hawking's theories about extraterrestrial life. Their answers surprised us, and inspired us to compile this list of other Hollywood believers. Read Full Story
Demi Lovato gets real about Taylor Swift's dating history by Jaclyn Brandt Oct 22, 2014 Share Tweet Pin Share Save Demi Lovato has been through a lot in her life, experience that has given her the wisdom a 22-year-old might not normally have. Lovato may be a recovering addict, but she doesn't let that define her. She is first and foremost a strong woman and a good friend — and she says her new mission is "inspiring everybody to be honest." Read Full Story
Watch out, Wilmer Valderrama! Demi Lovato is engaged to another man (VIDEO) by Kristyn Burtt Oct 14, 2014 Share Tweet Pin Share Save This might be the video of the week, because it will give you the warm fuzzies after viewing the cutest proposal ever. Demi Lovato was in Moline, Illinois, on Saturday when she got the question of a lifetime from a most unlikely source. Read Full Story
Demi Lovato has a few choice words about Nick Jonas' package by James Dinh Oct 09, 2014 Share Tweet Pin Share Save Nick Jonas basically broke the internet when he posted a shirtless photo of himself on Instagram last year. Read Full Story


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The belated loquaciousness of retired Supreme Court judge Markandey Katju over the appointment of a corrupt judge in the Madras High Court has at least one big virtue: it forces us to re-evaluate all the lies we have been told, or the ones we have been telling ourselves, about the benign nature of the Sonia Gandhi-Manmohan Singh partnership in 10 years of UPA misrule.The biggest untruth we wanted to believe in was this one: that Manmohan Singh was an honest man caught in the tentacles of coalition dharma (or rather adharma) and that he was single-handedly trying to keep the flag of economic reforms and probity flying in difficult circumstances. So we dismissed all evidence pointing to the contrary, which showed his tacit, if not explicit, permission for corruption. In the 2G, Coalgate and CWG scams, we blamed others and assumed that Singh was forced to look the other way. Comrade Katju's dirty-linen washing act tells us otherwise. It now appears that Manmohan Singh openly batted for a corrupt judge, now identified as the late S Ashok Kumar. In a letter dated 17 June 2005, according to The Times of India, the PMO sent a note to the law ministry about this corrupt judge. The note said: "The Prime Minister has directed that clarifications be sought by the ministry of law and justice as to why the names of Justice S Ashok Kumar and Justice NR Kannadasan have not been recommended (for confirmation as additional judge). The proposal be resubmitted (to the collegium) with the clarification".Now, this is no sin of omission or about Singh looking the other way when bad things happened. This was Manmohan Singh's direct handiwork - a sin of commission in asking a reluctant judiciary to extend the services of a corrupt judge. This is evident from then Chief Justice RC Lahoti's note, which, inter alia, said: While the opinion of the collegium is clear....however in view of the sensitivity in the perception of the government, the matter can be postponed for being further enquired into. Justice S Ashok Kumar may be given an extension for a reasonable time as additional judge." (Italics ours). A Prime Minister piles on political pressure through the Law Minister HR Bhardwaj, and the judiciary bends to serve him. In this case Manmohan Singh's hand clearly was the one that fired the gun, and not merely the shoulder from which someone else did the firing.The obfuscating assumption that Singh was forced to do things despite his "honest" inclinations is clearly one we must question. Singh was not forced to write this letter. Even if his party boss wanted him to do this, he could have asked the law minister, the ever-willing-to-oblige Bhardwaj, a Gandhi family loyalist, to do the dirty work himself. This would have given the PM plausible deniability. But the PM did it all himself and Bhardwaj became the emissary.One can only speculate about why Justice Lahoti obliged. The fact that Manmohan Singh was seen as an honest man could not but have helped him justify his decision to wave Ashok Kumars extension through despite his misgivings.The unravelling of the "honest PM" claim helps us debunk a second and related lie: that Sonia Gandhi spurned the prime ministership because she did not lust after power. In fact, we now know that she not only wielded full power despite being only a party head, but wielding it was possible only with Manmohan Singh as PM. The projection of Singh as the honest saint was what enabled her to consolidate power and get everything she wanted done without anyone raising a note of protest.If we hark back to every scam, every dubious move of the government, and especially the ones the Dynasty was directly interested in, Congress spokespersons always pointed to Manmohan Singh's spotless record to debunk charges that the UPA was encouraging corruption. When allegations of corruption were flying thick and fast against Manmohan Singhs government in the heat of the Anna movement, Sonia defended Singh: The manner in which Opposition and some anti-Congress elements are, as part of a conspiracy, levelling baseless allegations against the Prime Minister, the UPA government, the party and some of our colleagues, is a matter of regret.Last year, with elections in sight, Sonia defended Singh even when her own son Rahul insulted him by calling the ordinance to protect convicted legislators from disqualification as nonsense. She said: They (the BJP) make fun of our party, they make fun of our Prime Minister. The whole party stands behind the Prime Minister.This was obviously stretching the truth, for the whole party was not behind Singh, but it emphasised Sonias deep investment in Manmohan Singh and his honest faade.By putting up Singh as mascot, the UPA government could allow all the scams to take place, including the coal blocks allocation scam in which Singh himself was the minister in charge. It also allowed Law Minister Bhardwaj to allow Sonias friend Ottavio Quattrochi, a beneficiary in the Bofors payoffs, to walk free and unfreeze his booty (read here and here). If Sonia had been PM herself, she could never have distanced herself from this. Ditto for the scheme to take over a Rs 2,000 crore property the Herald House real estate in a private trust where she and Rahul were the main shareowners. They used Congress party money to get this done.The art of using honest people to get dubious deals done has been used by the UPA political dispensation even before. Like Manmohan, former Defence Minister AK Antony is another honest Sam, never accused of taking a rupee anywhere. But under Antonys watch, defence scams were popping up everywhere. The biggest, and most hushed up one, was a Rs 10,000 crore deal done with Israel Aerospace Industries which involved the payment of Rs 600 crore as business charges. Nobody knows where these business charges went, and what their purpose was. But Antony could not be accused of any wrongdoing. So there was nobody to attack.Clearly, both Sonia and Manmohan Singh knew what their bargain was: Singh gets to be PM, and he allows all that she wanted done whether in the interests of managing the coalition, or securing her own dynastic interests.The third lie was debunked earlier this year, when the widespread belief that there was a dual power structure agreed between Sonia and Manmohan. Manmohan Singhs former media advisor Sanjaya Baru, in his book The Accidental Prime Minister, quoted Singh himself as admitting that there was only one power centre - Sonia Gandhi. Singh told Baru: I have to come to terms with this. There cannot be two centres of power. That creates confusion. I have to accept that the party president is the centre of power.The victims of this prime ministerial accident were the citizens of the country, once the easy growth years of UPA-1 got over.The larger point is this: since it is nobody's case that Manmohan Singh was a simpleton who had no idea he was being used by the dynasty for their own dubious political purposes, it follows that he was complicit in many of the sins of commission and omission committed during his watch.Dr Jekyll and Mr Hyde were one and the same person. We have to stop telling ourselves lies about what honest Manmohan Singh was all about.
from IANS
Around 50 pc voting in Karnataka bypolls
Around 50 percent of over 3.6 million voters cast their ballots Wednesday in the bypolls for two Lok Sabha seats from Karnataka, an official said.
from IANS
Mumbai gangrape: Politicians express shock
Political leaders cut across party lines on Friday to condemn the gangrape of a photojournalist in Mumbai.
from IBNLive
TDP MP N Harikrishna quits Rajya Sabha
Telugu Desam Party (TDP) MP N Harikrishna has resigned from the Rajya Sabha to protest against the formation of Telangana.
from IBNLive
Harshvardhan, Vijay Goel eye CM post
An all-out factional war has broken out between Harshvardhan and Delhi BJP chief Vijay Goel, with both vying for the Chief Minister's post if the party comes to power.
from CNN-IBN
Congress has 2 by-polls in Karnataka
It is a crucial day for the Congress in Karnataka as by-polls began in Mandya and Bangalore Rural constituencies on Wednesday.
from PTI
Social media can't help in elections: Tharoor
Shashi Tharoor on Tuesday said the platform alone cannot help win elections but gives new options of reaching out to public.
from IBNLive
'Centre only worried about saving its chair'
Gujarat Chief Minister Narendra Modi said the Centre was neither concerned about the economy nor the falling rupee but only worried about saving its chair.


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The EAFL - Probably the best Madden 15 PS4 online franchise league in Europe. Now in our 20th season!
eafl, european, american, football, league, madden, online, franchise, europe, gaming, e.a.f.l, playstation
Unofficial Worldwide LM. C Fanclub. Run by Fans, For Fans. We are unofficial and are not in contact with LM. C in any way.
family, lm.c, international, fanclub, forum, gang, maya, #aiji, denki, jrock, japanese, rock, music, visual, lyrics, translation, translations, team


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Am I right? currently there is no game loader for the ps3 iso out there?Sponsored Links
Am I right? currently there is no game loader for the ps3 iso out there?Sponsored Links
Correct- there is no current PS3 iSO Loader yet. However, the first step is really to start burning some of these images to Blu-ray recordable media and try "Hot-Swapping" with the PS3 disassembled. If they don't even allow the game to continue running when Hot-Swapped with an original disc of the same title, then chances are it'll be an uphill battle unless an exploit or something similar is discovered.Sponsored Links
This is some great information.Sponsored Links
Hopefully, someone will figure out how to run OS X on the PS3, which would be pretty bad ass.
Results should be pretty slow with Mac OS seeing like Windows XP is slow as hell. Both OS's would be sucking the hell out of the PS3 memory.
It sucks that the Other OS can only use 256MB of PS3 memory. Someday we'll probably be able to change that if the PS3 truly does function like a computer.
However, if OS X is running on its own without linux, then it might operate smoother than if it were emulated on linux.
Yes, just burn the Fedora Core 5 .iso to DVD via ImgBurn or DVD Decrypter, and burn the AddOn .iso to CD via Alcohol120%. then follow the install directions I posted earlier.
can anyone give me a link to CELL-Linux-CL_20061110-ADDON.iso. havent The link on the front page is busted. thanks
i have finished installing fedora core but now it is asking for new unix pw. what do i do at this point?


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King James Version (KJV) | New International Version (NIV) |
5 Wilt thou be angry with us for ever? wilt thou draw out thine anger to all generations? | 5 Will you be angry with us forever? Will you prolong your anger through all generations? |
The King James Version is in the public domain. (The King James Bible Version Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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The Comic Strip
This page has been viewed 17 times this month, and 1893 times total.
- The Comic Strip Cartoon Episode Guide
- Rankin Bass Productions
- Distributed by: Lorimar-Telepictures
- Cartoon Characters: Karate Kat, Meow-Baby, "Big Mama" Katie McClaw, Katmandu, Cat Gut, Dracky, Wolfie, Mumm-O, Franklin, Blank-O, Sherman, Melissa, Gary the counselor, Lagoon the lifeguard, Caw, Melvin, Jinx, The Phantom, Clutz, Dr. Jekyll/Mr. Hyde, Doctor Slick, Big Mac, Spider, Honey Love Loretta, Moose the Loose, Snappy, Dolph, Doc Walro, Lorca, Mako, Spike Marlin, Bronc, T-Ray, Walleye, Lump, Dragonstein, Carper, Grunt, Captain Bizarrly, Hydra, Gobi.
- Voice Actors: Robert McFadden, Earl Hammond, Maggie Jacobson, Larry Kenney, Gerrianne Raphael, Jim Meskimen, Seth Green, Jim Brownold, Josh Blake, Danielle DuClos; Full Voice Cast ...
- Produced By Arthur Rankin Jr, Jules Bass, Lee Dannacher..
- Animated By Pacific Animation Corporation.
- Written By Peter Lawrence.
- Music: Bernard Hoffer.
- First Aired on September 07, 1987.
- Originally Released in Syndication.
- Running Time: 120 minutes.
- Color
Cartoon Summary:
This two-hour series was a marathon of four first-run cartoons in one episodic adventure each week. The four shows were: "Karate Kat," "Mini-Monsters," "The Street... (more)
Cartoon Production Information:
Stations had the option of running each of the cartoons individually to form a 30-minute daily series, although they could also run them together as a weekly two-hour series, typically on a Saturday.... (more)
Cartoon Video:
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Submit Additional Information:
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Report Errors / Submit Additional Information
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The Comic Strip
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The comic strip was without question one of the most unique cartoon experiences of my youth. It was one thing to enjoy a good cartoon in the golden mid-late eighties cartoon era, but to have four pretty well animated, very funny, and very entertaining shows... (read more)
3 of 7 people found this comment useful


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Originally published Sunday, June 29, 2014 at 8:03 PM
Drones, data, digital tracking: Someone's watching over you
We need to keep an eye on the technology that's keeping an eye on us.
Seattle Times staff columnist
In the future, I'm guessing, a drone hovering outside your window won't be alarming. We'll have adapted to the intrusiveness, or maybe there won't be a drone there because we will have created restrictions to preserve our privacy. It could go either way.
We humans are set apart from most other species not just by our really useful opposing thumbs, but by having the ability to think about the future and therefore to affect how it turns out. It's an ability that works well in the short term, but, as with weather prediction, the further we try to see into the future, the fuzzier our vision becomes. Still, we have to try because success gives us tremendous survival advantages.
A drone peeking through a window would be right at home in a sci-fi movie, but the incident was less dramatic than it first seemed. A woman in a 26th-floor apartment in downtown Seattle thought the drone was watching her get dressed. A company in Portland later said the drone belonged to it and was photographing property for a construction company, not spying on individuals.
The drone incident set me thinking about recent announcements from Amazon, Google and Apple that will shape our future. Those companies are keeping an eye on you, or at least on your data, and not secretly. Amazon announced this month that its new Fire Phone will make life easier for users to shop for and buy products from Amazon when they use a new app that can identify products phone owners are looking at or songs they're hearing.
Most of us are already having our habits analyzed. Netflix keeps track of what I watch so that it can suggest movies or TV shows, and Amazon does the same with books and other purchases.
Sometimes digital tracking still surprises me. I was shopping for shirts online at home recently and the next day the browser on my work computer showed me a couple of ads for shirts. Stuff like that happens from time to time and reminds me the Web can find me wherever I am. That's usually helpful, but sometimes it concerns me, though not enough to work at pulling the digital shades.
My auto-insurance company sent me an invitation to install a device on my car that would monitor my driving and send information to the company that could be used to lower my rates. It sounds like a good idea, but even benign information can be misused. I'm still thinking about it.
And I think it's reasonable to wonder what happens when one or two companies have fingers in multiple aspects of a person's life.
Google and Apple are also spreading their presence across multiple platforms and tying them together ever more tightly, not just phones and computers and tablets, but cars and home devices.
Apple has its home-automation product, HomeKit, which could take home automation to another level.
Google and Apple both announced new software for cars this year. It makes good business sense to draw customers ever more tightly into one universe. Companies have been doing more and more of that in recent years. It's hard to switch when all your stuff is in one company's cloud or to change any gadget when they're all tied together so nicely.
Most of these new capabilities are cool and convenient, but maybe we can't see the full effects yet.
Sometimes sci-fi images occur to me: the optimistic technological world of "Star Trek," or the suggestion of "The Matrix" that technology will turn the tables and control us, or maybe Hal from "2001: A Space Odyssey" just doing what it thinks is best for the mission.
Maybe there's a different script in which we gradually evolve from nation-states to company-states not defined by physical territory but by which systems define our lives: a Google person, an Amazon person. We'll be bundled people. Or, less dramatically, we'll just shop more, spend more and freak out if the power goes out.
Maybe there's nothing to worry about, but I think we probably should keep an eye on who and what's at the window just in case.
Jerry Large's column appears Monday and Thursday. Reach him at 206-464-3346 or firstname.lastname@example.com
Also in Local News
I try to write about the intersections of everyday life and big issues. I like to invite readers to think a little differently. The topics I choose represent the things in which I take an interest, and I try to deal with them the way most folks would, sometimes seriously, sometimes with a sense of humor. My column runs Mondays and Thursdays.
email@example.com | 206-464-3346


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Proctor District, Tacoma, Washington
This article does not cite any references or sources. (November 2008) |
The Proctor District is a business district in the north end of Tacoma, Washington. Primarily a center for locals to shop, the District has cultivated a small town "urban village" character.
The Proctor District is home to many unique, family owned small businesses. The venerable old Blue Mouse Theatre, built in 1923, is the oldest continuously operating movie theater in Washington State and is open seven days a week. The Blue Mouse celebrated its 90th birthday on November 12, 2013. Two Saturdays a month, Rocky Horror Picture Show brings in crowds. There are many restaurants including Europa Bistro, East West Cafe, Pomodoro, La Fondita, Knapps and Pour At Four. Proctor is also home to US Bank, Key Bank and Umpqua Bank. There is a veterinary clinic and a range of businesses that attract shoppers from surrounding areas as well as nearby neighborhoods.
The Pacific Northwest Shop (Proctor and North 27th) specializes in products made exclusively in the Pacific Northwest. For a complete list of shops go to http://proctordistrict.com/
An important development in the mid-1990s was the arrival of the supermarket Queen Anne Thriftway, now Metropolitan Market, which moved in across from Safeway at the corner of North 25th and Proctor.
The center of the Proctor District is located at the cross streets of Proctor Street and North 26th Street in Tacoma. The 1927 Proctor Street bridge just north of the district was rebuilt in 2006.
Schools and churches[edit]
The Proctor District is the site of two public schools (Washington-Hoyt Elementary School and Mason Middle School), a public library (Anna Lemon Wheelock Public Library), and a church (Mason United Methodist Church), as well as a number of charitable organizations.
Farmers' market and community activity[edit]
Proctor has a lively farmers' market, the second largest in the city, which runs from the last weekend in March through the second-to-last weekend in December on Saturdays from 9:00 a.m. to 2:00 p.m.
External links[edit]
- Proctor Association Website
- City of Tacoma
- North End Neighborhood Council
- Neighborhood Tacoma Business Districts - Proctor Business District
- Historical Proctor District
- Mason United Methodist Church
- Proctor Farmers Market
- Proctor District Store Directory
Coordinates: 47°16′16″N 122°29′20″W / 47.2711°N 122.4889°W


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I just made my first all grain stout. It was a lot easier than I thought it would be. I was a little off with my OG, but the barley was cracked at the store and I did not think it was cracked very well. Anyway, I was thinking of killing two birds with one stone. I only have a 6.5 and 5 gallon glass carboy, but if I put CO2 in the carboys first and then split the wort up, to get my creamy stout and stout, would that work? At the moment I can not buy 2 - 2 gallon carboys. Thanks in advance.
Fairy tales do not tell children that dragons exist. Children already know that dragons exist. Fairy tales tell children that dragons can be killed.
i say fill one all the way, brew another, then fill the other, but thats just me
I think that you are way too worried. The brew will not get oxidized while you are awaiting fermentation. People go to great pains to aerate before fermentation. Purging with CO2 is not necessary and I would split the batches if you want to. Was oxidation really your concern?
What's the plan/difference between your stout & creamy stout from the same wort? I um confused.
FYI - There's a great Mackeson's XXX milk (cream) stout recipe in Clone Brews; lots of lactose and lip-smackin' good


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Complimentary wireless high-speed Internet access is available to guests in public areas (one hour of free use). Other amenities include a 24-hour fitness center, 24-hour room service, and 11,690 square feet (1086 square meters) of meeting space.
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The hotel's 426 nonsmoking and modern guestrooms feature interactive televisions with video games, minibars, Internet access, and coffee/tea-making facilities.
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