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Nightlife in Korea: Bars, Clubs, and Dancing
So today we're gonna talk about nightlife in Korea. DISCLAIMER: we didn't do everything there is to do with Nightlife in Korea. We've never been to booking clubs or host bars, but we have been to a bunch of bars and dance clubs. So, for the latter two we can speak about with a lot of experience. For the former two, we're basing this off of what our friends have told us.
Side note: none of our friends have actually gone to host bars themselves. They always tell the story like "well, I KNOW A GUY who goes and this is what he does" or "I've been with some people at a host bar and this is what they did, but I never did that myself." You know, now that we think about it, we're not even sure why we talked about host bars, because we doubt that any of you have ever went or actually have the desire to go yourselves. Do you? We made them sound, at first, like Ouran Host Club, but that's a bit misleading, because Ouran Host Club is wonderful and magical and makes you feel special on the inside. Host clubs in Korea, from how they've been described to us, are a lot more…umm. Not innocent. Anyhow, the whole point of talking about this is just for you to know that they, indeed, do exist.
Dancing, though, we know! We just don't do it that much. Hongdae's where we usually go dancing. Club FF is our favourite, because they play Indie Music, both Korean and international. Just last weekend we were there and they played Crystal Castles, which is our most played band on iTunes EVER. But that's just when it's the two of us wanting to go out dancing together. If we're with a group of friends and they're looking for something more danceable, we go to the more Korean-ized dance clubs that play THAT GODFORSAKEN SONG FAR TOO MUCH. What is that song with the soccer dance? You know what I mean, right? What's the name of this song? 100 points to the first team to name it! And if someone has a video of that dance, then 200 points! We never took a video of it ourselves. We got soooome footage of dancing at night when Martina broke her ankle, because she broke her foot when she tried to do another dance outside of the soccer dance. THAT DAMN SOCCER DANCE, I TELL YOU!
Otherwise, we talked about Hongdae's Free Park a bit at the end. We really like it there, but we didn't really describe it well. Basically, it's a really small area, not really even a park, but it's outdoors, by a swing set, with a few trees around it, and people just…hang out there. People bring their own drinks and just chat with friends. Other things happen around that area. Some people play live music. Sometimes there's a Silent Disco, in which you rent a set of wireless headphones and dance to music that the DJ's playing. It's totally awesome, because – to you – you're like "AHH YEAH DIS MAAH SONNNNGG!" and you can dance with a bunch of people, but to the outsiders, to those without headphones, it looks really weird watching people dance to music you can't hear. Last Saturday there was impromptu boxing. Yep. A dude had boxing gloves and boxing helmets and let people box. We saw one dude, really arrogant, get knocked on his ass. Great times! Nothing like foreigners beating each other up for sport! But, no, really: it's got a great vibe, the Free Park, and we hang out there whenever we get the chance.
Don't ask us much about Gangnam nightlife. We're a bit anti-Gangnam. Nothing against Psy. It's just too stooshy for our tastes. Too rich for my blood, I'd say.
So, yeah! That's a bit about nightlife in Korea. Long story short: hang out in Hongdae. It's the best!
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I have heard a lot about music being popular in Korea but I haven't heard much about sports in Korea. Is there as much enthusiasm with sports as there is in America or Canada?
Well if you ever film in a bar or club in Korea I have 2 requests. 1) Invite some fans that are in Korea so everyone can get an experience of ppl having thier first time at these places and 2) do it in early feb so I can include my wife when she visits me here lol!!!
OMG Hanging outin the Hongdae free park is da best. I totally discovered it by accident one night coming out of
Shuffle? dance? maybe?
I went to Korea for 2 weeks and I was lucky enough to experience most of the nightlife they describe minus the booking & host clubs ….was also fortunate enough to actually go to 2 different clubs in Gangnam for FREE and just it is VERY stuck up and snobby and you can get a beer for 15,000 wons!! F-ing insane…thats like $15! LOL Mojitos are $25 ..
Is it this one?
hi guys! you should definitively try Obeg (500) club in hongdae! that clubis amazing, its a kind of north african-indian style club (clay wall with ethnics paints)! When there is not special event, its super calm with indie music, sit on the floor with pillow and caddles everywhere, drinking sangria and smoking chicha…here you can find the very rare koreans rasta guy of seoul! ^^ its a total travel outside korea in heart of hongdae life!
Are you guys talking about this song?
http://www.youtube.com/watch?v=1GnyKTJZmM0 -
DId anyone ever figure out what the song/dance is?
I have a question that I have been wondering 4 a long-time: this place is near gangnam MRT, There's this group of very handsome guys ( 6 or 7 of them, level of handsomeness= like models) in smart suits standing outside a building. They invited girls only to go into a building. One pulled me and start talking in Korean. I was like 'What do ya want (cos I dun understand Korean)'. He refused to let go and continue to talk a lot . I finally said in English 'I AM A TOURIST', he then let me go.What I do notice is most korean girls that they approached either ignore or wave them away. Till now I could not find out what was that about. I do not think that they were selling a product, cos they were not holding anything. Other than the Famous Gangnam style song and the fact that SM entertainment agency is located there , and there are a lot of celebrity restaurants, what else is Gangnam famous for ? Maybe it can provide as a lead for me. Anyone can solve the mystery?
Interesting introduction to nightlife in Korea. How about livehouses? Like with live bands and stuff. Those are huge in Japan, not too bad in Taiwan and kind of pathetic in Singapore.
And that bit about organized dancing. Reminds me of Mambo Night in Singapore at Zouk. XD
What you said about the organized "soccer" dance, reminded me of how here in mexico, every party you attend, it doesn't matter if it's a wedding, a birthday, a baptism or whatever, the Spanish version of "Achy breaky heart" and other similar song MUST be played at some point of the party. And really, freaking everyone stands up to dance. The dancefloor gets so crowded it's nearly impossible to finish it without even getting stepped on feet at least twice.
here in Brazil is the oposite, you interact A LOT with strangers, mainly if you are drunk
i lost it when they martina sang kiss kiss fall in love >.<
Martina and Simon,
I wanted to share this funny story with you. I was on a subway train in Boston today, reading Dramabeans and listening to Clazziquai, as is my wont, and what do I hear over the dulcet tones of Alex and Horan but two college girls discussing your blog. Rather, one girl was telling the other all about Simon, Martina, Spudgy, Dr. Meemersworth, WANK-ing and SPANK-ing, and the other girl was looking at her like she had two heads — the way my friends and family look at me when I tell them about all things Korean. I thought I'll pass this on — Eat Your Kimchi Fighting! -
hi …i have always wondered why does korean or most of asians when they want to focus or to do something right and good they wear a wight headband ? exaple i saw a lot of scenes in korean dramas and movies where students waer it when they want to study for something big . so what does it means …?
hello! i've got a question, but it's not very easy to ask. here goes!
the country i would most want to visit is South Korea, because of the music, the culture, the food, the exceptional public transportation, and so on. the country i would least want to visit is North Korea, probably for obvious reasons. so my question is: how do South Koreans feel about people who have the same culture, the same history until so recently, living so near and so horribly. if the other half of MY country was living in poverty and misery, i think it would bother me every day.
any thoughts from Simon & Martina? -
to Martina: Did any korean man ever hit on you since you came to Korea?
I wonder what it's like in Korea for people who don't drink. I hate alcohol and refuse to drink even a sip during holidays where it's common to drink. I wouldn't want to be considered rude or weird but I wouldn't want to change that just because I was in a country where pretty much everyone drinks. I wonder if I lied about having an alcohol allergy if they'd be fine with me not drinking xD
Hmm…the organized dancing reminds me of the Macarena (good old 90s tune :P). Whenever any of my friends (of any age) hear this song, they all jump up and dance to this.
http://youtu.be/XiBYM6g8Tck -
I don't know if anyone has told you the name of the 'soccer dance song', it's 'Riverside mother fucker' I think. Search it on youtube! :3
Hum. I've got a question :)
In Montreal (Canada), people are very open and there are varieties of everything (Food, Style, Shops…) In Korea, how are they? Are they different?
Is this that electro song?? xP
i was wondering since poor martina broke her ankle i wanted to know how are the hospitals there i mean do you pay like cash or credit card or you have insurance how does it work?
Here's a video of the dance (maybe?), apparently to the wrong song, though, and the part in question starts about 1:40 :
http://www.youtube.com/watch?v=uW9pNDUZKj8The song here is a hard-rock cover of my introduction to K-pop, Clon's "Kkungttari syabara". I've no idea who does it and the uploader didn't say.
Here's another one, and the dance is apparently called the "KKokjijeom Dance (꼭지점 댄스)", meaning "Vertex Dance"(?):
http://www.youtube.com/watch?v=nzMdlIdtIwQMore quick YouTube searching yielded the title "오 필승 고리아" (O Pilseung Koria, "O Victory Korea")—which sounds nothing like the one you tried to sing:
http://www.youtube.com/watch?v=Dk6wnEkHZhQAnother search yielded the name of the original performer, the Yoon Do-hyun Band:
http://www.youtube.com/watch?v=r5Ao1baj6Mo -
I think the techno song you guys are looking for is Riverside by Sidney Samson :)
Dear Simon and Martina,
From my studies (and word-of-mouth) I know that South Korea has a very distinct drinking culture. A lot of emphasis is put on social drinking and, from what I've heard, if you don't drink you're considered anti-social.
I'm currently on my way to a Linguistics degree in hopes of moving to Korea to teach English. I don't particularly care for alcohol, in fact, I'd have to say that I downright don't like it. (Nothing against drinking, I just dislike the flavor of alcohol.) I don't want to seem rude when I get over there by not drinking, but I also don't want to be forced to do conform for the sake of being liked.
So my question is, is there anything that someone who dislikes alcohol can do to get around drinking without making the situation awkward? If not, how many drinks would generally be the minimum to consume in a social situation?-
When I was in Korea there was another foreigner that hung out with our group who didn't drink. People were a bit curious about it, but I think the thing that offended the Koreans was that he didn't want to pay for the alcohol (which, seriously, it's not that expensive) and this threw a wrench in the proceedings, because the Koreans were so used to just splitting the check. To figure out how much someone should have to pay without the alcohol was just a ridiculous extra complication. So if you're going to not drink, just don't make a big deal about it.
Of course this is just my experience as a student there for three short months.
And hey, I am also a Linguistics major (well, graduated a year ago) and I'm hoping to go back as a teacher too. Good luck with your plans!-
How interesting. I've always heard that splitting the check is considered atypical in Korean society. (I can't confirm or deny this, as I've yet to visit Korea. It's just the way I've learned things.) Perhaps it differs from person to person…
Fortunately, I'm very used to splitting bills out of habit, so I don't think I'd have too much of a problem with that myself. If paying an extra dollar or two means I can get away with not drinking, that's fine by me. Heheh.-
I think the splitting of the bill was really just because we were all students. I imagine that beyond the university world, they probably don't do that as much. Technically in Korea, I think the one who invites usually pays, but if the university students followed that, no one would want to invite a group of friends out because it would be too expensive.
Ah. Yeah, that would make sense. College students are broke no matter what country they live in, I suppose. XD
Hey guys! Have you ever been allowed to tape inside a "dance club?" I think we'd all like to see Simon trying to do a group dance (or rather to his own "nasty" version!).
On a more serious note…Simon – You looked so tired in the video. Were you guys taping late? I hope you aren't getting sick! Please take care of yourself and stay healthy! :-)
lol i'm also more of an organized dance person which is why i like kpop so much. Because I can actually learn the moves and dance to it! But with american or arab music i'm sooooooo lost and awkward and don't know how to move my body…this is what happens when you're a nerd i believe… O_O lol :P
LOVE CRYSTAL CASTLES. Yeah. Thats all I really wanted to say. ^^
Can you guys do a TL;DR on the proper way to desert my life in California, move to Korea, and work for you as a stylist/fashion designer/shopper? Is that too narrow of a topic? I hope not. I MUST KNOW!! haha! Forget idolizing the k-pop idols, you guys are my idols!!!! Also, Booking clubs sounds delightfully awkward. It would be so much fun to be the wingman waiter and hook up tables. I would feel diabolical! MWAHAHA!
The song they're referring is called "Riverside" http://www.youtube.com/watch?v=Pde2j70eiC8
I have a question, which is the perception of the Koreans with respect to latinos, it is different from that of the Americans???.. (sorry for my english, i use bing translator) :(
There were a couple latinos in the group of students I was with in Korea last spring. I didn't notice that they were treated any differently. We were all just foreigners. Some of the girls were quite fascinated with the girls' long eyelashes and big eyes… but nothing too out of the ordinary. Just another foreigner.
How cool is this! Less than $500 is needed to put our wonderful Simon and Martina over $100,000.00 in the fundraiser! AND there are still 24 days to donate!!!! WOW, they may actually get to sleep before this year is out!!!!! I am so proud of the Nasties! I am also proud and grateful to S&M for creating a place/product that is of such a quality that people fall over themselves to help them continue!!!!
Since food is such a huge part of culture and these things tend to be vastly different from one country to the next, can you tell us about Korean table manners?

subset: commoncrawl


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text: ASTORINO/MOSS JOBS PLAN New York State once led the world in manufacturing, innovation and job creation but today it's largely propped up by a relatively strong financial services economy based in Manhattan. Recent third-party economic and business analyses have not been kind to New York. Due to our status as the highest taxed and most regulated state in America, the Tax Foundation ranks New York as having the 3rd worst business climate in the nation. The American Legislative Exchange Council ranks New York dead last in the nation for economic outlook. And a recent study conducted for the U.S. Conference of Mayors ranked 10 New York metropolitan areas in the bottom 20 out of 363 for economic growth forecast – Binghamton and Utica were dead last. Ask just about any New Yorker outside of a few select neighborhoods in Manhattan or Brooklyn and they'll tell you themselves how they, their neighbor or family member are unemployed or underemployed and how they have anxiety over the state of New York's economic condition and prospects for the future. Ask any of the 400,000 New Yorkers who have fled the state since 2010 and they'll tell you they left for better economic opportunities and a lower cost of living elsewhere. How did we get to this point? The housing crisis and the global recession only tell part of the story. New York State government has been hostile to private enterprise for many years and it has gotten no better – in fact, it's gotten worse – under Governor Cuomo as the state's decline steepens. Despite the millions of dollars in bogus and corrupt taxpayer-funded campaign TV advertisements run by Cuomo, New York is unfortunately not "open for business." Governor Cuomo's economic development strategy has too often relied on a mix of crony capitalism, backroom deals and marketing gimmicks. In his first State of the State address in 2011, Governor Cuomo promised "radical reform" but we've seen none of it. By any measure, we're either treading water at best or outright drowning at worst. As 30 states and President Obama support natural gas exploration, Cuomo stays mute, refusing to make a decision, and starving economically depressed upstate of tens of thousands of good-paying jobs that have transformed many other states. As every other state has labor laws that assign fault in worksite injury, New York maintains an 1885 law, known as the "Scaffold Law," that makes contractors, employers and property owners absolutely liable regardless of evidence of worker negligence. The Scaffold Law is typical of a hostile and anti-business regulatory environment in this state that's simply a job killer. Last year a bipartisan Senate regulatory reform group called the regulatory climate in New York, "death by a thousand cuts for businesses and entrepreneurs." It's more like 750,000 cuts. That's the number of regulations the business community must adhere to. And if that wasn't bad enough they must deal with high taxes and the infamous delays, uncertainty and costs that comes with the New York's outdated and unaccountable permitting, licensing and contracting process. An antiquated approach to hi-tech start up ventures is another job killer. California is often as misguided as New York in governing but when it comes to embracing hi-tech start-ups New York could learn a thing or two about leveraging and retaining the brainpower that comes out of our excellent colleges and universities. For example, there are 12,000 members of a San Francisco-based Cornell Alumni Group. Imagine if we were able to retain even just 20% of them and what that would mean for our economy. And while taxpayer money is being wasted left and right in this state, a universally accepted role of government to help the economy and safety of its citizens – investing in the state's infrastructure – is being neglected. Recent estimates show that 32% of New York's bridges are rated deficient; 40% of our roads are rated fair or poor; and 83% of our parks and dams are in disrepair. The Astorino/Moss Jobs Plan is a straightforward reform agenda to improve the business climate and promote economic growth in New York State. Government doesn't create private sector jobs but it can establish the climate where private investment flows and job creation flourishes. We did it in Westchester and saw the creation of 30,000 new private sector jobs over four years and we can do the same for New York State by: Eliminating job-killing regulations and mandates Reducing the tax burden Investing in the rebuilding of New York's deteriorating infrastructure Moving forward with natural gas development in Upstate Accelerating hi-tech start-up creation Modernizing our workforce with the necessary skills and training Strengthening our agricultural heritage and economy 1. Regulatory Reform -Sign executive order on first day instituting a moratorium on any new regulation and a thorough review of the approximately 750,000 regulations currently on the books. -Adopt the 2,219 regulatory reforms proposed last January and thoroughly vetted by a bipartisan Senatorial working group that conducted nine industry-specific forums across the state. Among the reforms: Repeal the Scaffold Law Reform the State Environmental Quality Review (SEQR) by reducing costly delays and redundancies and increasing timeframe predictability. Reform the Workers Compensation system to include adopting American Medical Association guidelines and American College of Occupational and Environmental Medicine treatment protocols to cut down on costs. -Require agencies to publicly post approval timeframes for permits and licenses and if not adhered to, compensate the applicant for permit and licensing costs. -Eliminate the incorporation fees for LLCs and Partnerships. -Allow small businesses with less than 50 employees the option of self-insurance that would allow numerous exemptions from ObamaCare mandates. 2. Tax Relief (a more comprehensive Tax Relief Plan will be unveiled in the coming weeks) -Reduce or hold flat state spending in each of the next four years to begin to get state expenses and costs under control. -Make permanent the property tax cap. -Reduce property taxes and strengthen the effectiveness of the property tax cap by passing mandate relief, including reforms to the Medicaid program and Pension system. -Repeal hidden taxes on health insurance premiums levied through HCRA -Eliminate the 18a tax assessment on utility ratepayers. 3. Invest in New York's Infrastructure -Start by investing the $3.6 billion BNP Paribas bank settlement money into the most desperately needed repairs to our roads, bridges and mass transit. -Use portion of BNP settlement money to pay Canal Corporation debt, separate Canal from the Thruway budget and free up money that would otherwise have gone for Canal debt service to pay for infrastructure projects like the new Tappan Zee Bridge. -Dedicate sales tax revenue from gasoline purchases to pay for investments in roads, bridges and mass transit. 4. Accelerate Energy Development -Move forward with natural gas exploration and drilling in Upstate. Use SBC (System Benefit Charge) funds now at NYSERDA to help pay for the cost of bringing natural gas distribution lines to communities where the service currently doesn't exist. -Renew the Indian Point Energy Center license, support Massena in their efforts to be approved for a new plant. -Alleviate transmission congestion and upgrade the power grid. -Support other renewable energy sources like Solar, Wind and Hydro and provide grants and low interest loans to farms and businesses that make energy efficient improvements. 5. Accelerate Technology Start-Up Creation -Offer individuals a state income tax credit to encourage private investing in qualified start-up ventures. -Streamline the tech-transfer process at state colleges and universities so students and professors can more easily commercialize their inventions. -Pass a law that bans the enforceability of "non-compete agreements" – keeping more top talent in New York as it would open up greater opportunities for hi-tech workers and entrepreneurs by eliminating unnecessary restrictions on the flow of talent between companies. -Support entrepreneurial networks with technical assistance to encourage collaboration across communities and organizations that support start-ups. 6. Increase Availability of Skilled Workers -Create regional councils comprised of local educators and employers to help high schools tailor vocational education programs to match the needs and demands of local employers. -Make job-training investments directly to community colleges to streamline the training of new workers for local industry needs. -Increase coordination between community colleges, local school districts and local industry so students can be properly counseled on the present and future availability of jobs, the types of jobs, their pay and benefits, and the skills needed to do these jobs. 7. Strengthening our Agricultural Heritage and Economy -Create a New York Farmer's EZ-Pass that eliminates Thruway tolls for New York farm-based trucks transporting farm-to-market products. -Support the Ritchie/Magee legislation (S.4260/A.6024) that reduces taxes, fees and regulatory burdens on New York's family farmers. -Support a pilot program where beginning farmers receive tax incentives to start a farm in New York State.


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Cars > pacethisguy's Garage
About pacethisguy's Garage
My first car
started the motoring life with a 73 Chevy Nova w/ a lil 307. after a slight bump that killed the allignment i traded for a 74 AMC Gremlin X(forest green with ta gold stripe) been an AMC guy since that day lol!
My dream car
2009 Audi R8
- Type of racing: drifting and ralley
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— Profile last updated: Mar 3, 2009
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Bluegrass Farmers' Market Winter Warmer Uppers!
Bluegrass Farmers Market -
Thursday January 16, 2014 - By Kentucky Proud
It looks like we might get hit with another round of winter weather...hopefully not nearly as cold as the last blast! The great news...only 85 days and a wake up until we'll be opening our 2014 market season! :) Mark your calendars because April 12 th is the...


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Welcome to lindyb's Member Page
See my Clippings See my Journal See my trade list Send me an email
I was formerly LindaPNW8. A change in email address got me messed up.
I've been gardening for over 30 years but am new to roses. In 2002 I became smitten by old garden roses. Fortunately, my husband and I live on a small farm in western Oregon with enough room to accommodate the size of some of these old girls.
Here's my list of roses I currently have:
Abraham Darby
Alister Stella Gray
Belle Isis
Belle de Crecy
Blush Noisette
Cardinal de Richelieu
Catherine Mermet
Celine Forrestier
Charles de Mills
Darlow's Enigma
Eugene de Beauharnais
Frances Dubreuil
Gloire de Dijon
Gruss an Auchen
Jacqueline du Pre
Jude the Obscure
Lady Hillingdon
La Ville de Bruxelles
Madame Alfred Carriere
Madame Isaac Pereire
Madame Plantier
Maman Cochet, CL
Marie Pavie
Odee Pink
Perle d'Or
Princess de Sagan
Rose de Rescht
Rose du Roi
Souvenir de St. Anne's
Souvenir du Docteur Jamain
Souveni d'un Ami
Stanwell Perpetual
The Impressionist
Vineyard Song
Women in Military
Mountain Music - gift from a friend
Morning Has Broken - gift
Robert Clements - gift
I live in: United States
My zone is: z8 OR
My favorite forum 1 is Antique Roses.
My favorite forum 2 is Rose Gallery.
First registered on July 08, 2004 .


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10th Annual
April 22-23, 2015
A mutli-disciplinary gathering where you can gain new insights and refresh on new ideas through networking and presentations Djamal B., Arisan Therapeutics
A mutli-disciplinary gathering where you can gain new insights and refresh on new ideas through networking and presentations
Fragment-based approaches to find new small molecule drug candidates are now part of most drug discovery campaigns. The challenge of fragment-based drug design campaigns has always been progressing fragment hits against the target compound to obtaining a clinical candidate. Via case studies on success stories and compounds moving forward or not in preclinical development, this conference will highlight best practices and pitfalls to avoid. Join fellow drug discovery colleagues for this day-and-a-half meeting in the second half of CHI's larger Drug Discovery Chemistry event.
Day 1 | Day 2 | Download Brochure | Register
Wednesday, April 22
12:30 pm Registration
1:30 Chairperson's Remarks
Daniel A. Erlanson, Ph.D., Co-Founder, Carmot Therapeutics, Inc.
1:40 FEATURED PRESENTATION: Using Fragment-Based Lead Discovery towards Alternate Mechanisms: Inhibiting Ubiquitin Binding to USP7
Till Maurer, Ph.D., Senior Scientist, Structural Biology, Genentech
Small molecule inhibitors targeting the deubiquitinase Ubiquitin Specific Protease 7 (USP7) have potential as cancer therapeutics. Using ligand-based NMR in an activity agnostic FBLD effort, we have identified binders to several sites in USP7 including a unique site in the "palm" of USP7. These could be shown to be active. The palm series imply a very distinct mechanism of action independent of the catalytic triad by binding in a region involved in USP7-Ubiquitin interaction.
2:10 Irreversible Tethering: Fragment-Based Drug Discovery Technology for Covalent Enzyme and PPI Inhibitor Discovery
Alexander Statsyuk, Ph.D., Assistant Professor, Chemistry Department, Northwestern University
We developed a new technology in which weakly bound electrophilic drug-like fragments are irreversibly trapped on the catalytic or non-catalytic cysteines of protein targets. Subsequent intact protein MS can be used to identify fragment hits, allowing one to screen 100 or more fragments/day without the use of special robotic equipment. The developed technology can be used to discover covalent drug leads for enzyme inhibitors and protein-protein interaction inhibitors.
2:40 Fragment Hopping to Design Selective Inhibitors for Beta-Catenin/T Cell Factor Interactions
Haitao (Mark) Ji, Ph.D., Assistant Professor, Chemistry, University of Utah
The aberrant formation of the β-catenin/T cell factor (Tcf) complex in the canonical Wnt signaling pathway has been recognized as the major driving force for many cancers and fibroses. Crystallographic and biochemical analyses reveal that the binding modes of Tcf, cadherin and adenomatous polyposis coli (APC) with β-catenin are identical. By using a fragment hopping technique, we have successfully designed and synthesized potent small-molecule β-catenin/Tcf inhibitors with high selectivities over β-catenin/cadherin and β-catenin/APC interactions.
3:10 The Application of Extended Huckel Theory for Pharmacophore Modeling
Alain Ajamian, Ph.D., Director, Chemical Computing Group
Rocky Goldsmith, Ph.D., Applications Scientist, Chemical Computing Group
Pharmacophore models play an essential role in drug discovery. Generating pharmacophore models which encode accurate molecular recognition features are highly dependent on properly defined annotation points. Here we have developed a new approach for pharmacophore modeling which is based on a semi-empirical method using Extended Hückel Theory (EHT). The pharmacophore features generated through the EHT annotation scheme take into account ligand resonance and electron withdrawing effects and are sensitive to non-standard interactions, such as C-H and halogen bond interactions, during pharmacophore screening.
3:40 Celebratory 10th Annual Refreshment Break in the Exhibit Hall with Poster Viewing
4:20 Kinetic Target-Guided Synthesis: A Fragment-Based Lead Discovery Strategy based on the Bioorthogonal Sulfo-Click Reaction
Roman Manetsch, Ph.D., Associate Professor, Department of Chemistry and Chemical Biology, Northeastern University
Kinetic Target-Guided Synthesis (TGS) has been developed, in which the biological target is actively engaged in the irreversible assembly of its own inhibitory ligand from a library of reactive fragments. The Manetsch laboratory developed the first kinetic TGS approach for the identification of compounds disrupting protein-protein interactions. We demonstrated that the sulfo-click reaction, an amidation reaction between thio acids and sulfonyl azides, is suitable for a kinetic TGS approach targeting proteins of the Bcl-2 family.
4:50 Identification of Fragment Hits that Bind the SAM pocket of COMT
Mark Hixon, Ph.D., Principal Scientist, Medicinal Chemistry, Takeda
5:20 Breakout Discussions
In this session, attendees choose a specific roundtable discussion to join. Each group has a moderator to ensure focused conversations around key issues within the topic. The small group format allows participants to informally meet potential collaborators, share examples from their work and discuss ideas with peers. Check our website in February to see the full listing of breakout topics and moderators.
6:20 Close of Day
6:30 Dinner Short Courses*
*Separate registration required; please see page 4 for details
Thursday, April 23
8:00 am Morning Coffee
Fragment-Based Drug Discovery: A Fifteen Year (Re-)Evolution
Harren Jhoti, Ph.D., President & CEO, Astex Pharmaceuticals
Fragment-based discovery has now been successfully established as an alternative approach to HTS and has produced multiple drug candidates that are in clinical trials. Some of the appealing features of the approach include the ability to efficiently sample chemical space and to produce drug candidates that have superior physicochemical properties. In this talk I will provide a perspective on how Fragment-Based drug discovery evolved over the last 15 years and challenged conventional thinking in Drug Discovery.
9:30 Coffee Break in the Exhibit Hall with Poster Viewing
Best Practices, Advances and Challenges in Fragment-Based Discovery
10:10 Chairperson's Remarks
Roderick E. Hubbard, Ph.D., Director, Chemistry, Vernalis Research and University of York
10:15 Fragment Libraries and Screening the "Undruggable"
Justin Bower, Ph.D., Head, Chemistry and Structural Biology, Drug Discovery, The Beatson Institute for Cancer Research
This presentation will outline our approach to fragment library design and how we have incorporated descriptors of shape and complexity to complement more traditional approaches. I will also describe our approach to targeting several GTPases implicated in cancer.
10:45 Design of the Merck Fragment Library 2014: Incorporating Biologically Privileged Motifs, the Ability to Efficiently Interrogate SAR, and Expert Chemists' Assessment
Peter Kutchukian, Ph.D., Associate Principal Scientist, ChemInformatics, Merck and Co.
As opposed to focusing on desirable properties for a library (shape, physical properties, etc), the more novel design principles applied to the library will be described. Namely, 1) an integrated chemogenomics database of internal and external data was used to identify biologically privileged motifs for incorporation in the library, 2) library members and expansion analogues were selected based on a "diversified portfolio" approach to fragment hit follow up as opposed to the more standard nearest neighbor follow-up, and 3) visualization tools were built to empower medicinal chemists to readily use these guiding principles to select (or design) fragments that fulfilled these goals.
11:15 Sponsored Presentation (Opportunity Available)
11:30 Experiences with Fragment Libraries at Astex
Alison Woolford, Ph.D., Associate Director, Chemistry, Astex Pharmaceuticals
The Astex library has been through multiple rounds of enhancement since the last publication. Armed with thousands of proprietary protein-fragment crystal structures, across a wide range of protein families generated over 10 years, we will discuss how later iterations of the fragment library have been constructed and analysed. We will show how the fragment hit rate varies with lipophilicity and heavy atom count, and compare the hit rates of 2D versus 3D fragments. We will also present a recently disclosed initiative involving minimal binding pharmacophore elements that are appropriate for fragments and show how they have been used to drive library enhancement. These privileged pharmacophores have added value by generating novel fragment hits for progression into hit to lead chemistry.
12:00 pm Ligand Deconstruction and Library Design: Why Some Fragment Positions Are Conserved and Others Are Not?
Sandor Vajda, Ph.D., Professor, Biomedical Engineering and Chemistry, Boston University
FBDD relies on the premise that the binding mode of fragments is conserved upon expansion to a ligand. This hypothesis is frequently tested by deconstructing ligands into their fragments, and by determining whether the fragments still bind, and if they do, whether their locations are conserved. We show that a condition for fragment conservation can be developed in terms of binding hot spots, i.e., regions of the protein where interactions with any ligand contribute a large fraction of the binding free energy. The condition can be used to predict fragment size and shape in a library to be screened for a specific target, including non-traditional PPI targets and proteins that can be targeted only by macrocycles.
12:30 Walk and Talk Luncheon in the Exhibit Hall with Poster Viewing (last chance for viewing)
1:40 Chairperson's Remarks
1:45 Attacking Cancer with Fragments: BCL-2, MCL-1, and Apoptosis
Andrew Petros, Ph.D., Associate Research Fellow, Research & Development, AbbVie
2:15 Choosing and Using Fragments in Oncology Lead Discovery
Fragment methods have been used successfully for many oncology targets – to assess ligandability, to provide chemical tools to probe and validate target biology, and to generate candidates to progress into clinical trials. I will review some of our recent experiences in using fragments for lead and candidate discovery, with particular emphasis on the very early stages of developing fragment and early hit SAR to decide on which series to progress.
2:45 Refreshment Break
3:00 Exploring Possible Drug Target Conformational Changes by Fragment Screening
Barry Finzel, Ph.D., Professor, Medicinal Chemistry, University of Minnesota
Inhibitors of Mycobacterium tuberculosis BioA with high ligand efficiency have been identified by screening for compound-induced Tm shifts with Differential Scanning Fluorimetry (DSF). Structures with bound fragments sample an ensemble of different active site conformations that correlate with ligand binding. DSF shows that some of the ligands destabilize protein folding, while others are stabilizing, even though dissociation constants obtained by ITC are similar. Destabilizing ligands should not be ignored when searching for lead compounds.
3:30 Use of FBDD in the Discovery of Two Series of Potent Methionine Aminopeptidase-2 Inhibitors
Chris McBride, Staff Scientist, Medicinal Chemistry, Takeda
This presentation will demonstrate the strategy used to identify two series of methionine aminopeptidase-2 (MetAP2) inhibitors. Fragment libraries were screened for hits with high ligand-efficiency (LE) and orthogonal hit confirmation led to a low affinity indazole core being selected for directed elaboration with the aid of structural information. Additionally, structural insight and SAR from the indazole series led to the design and accelerated knowledge-based fragment growth of the pyrazolo[4,3-b]indoles as MetAP2 inhibitors.
4:00 FBDD on Metalloprotein Targets
Seth M. Cohen, Ph.D., Professor, Department of Chemistry and Biochemistry, University of California, San Diego
Most inhibitors of alloproteins employ a functional group that binds to the active site metal ion. We have developed an FBDD approach to metalloenzyme inhibitors by developing a library of suitable metal-binding pharmacophores (MBPs). Thermodynamic and structural investigations are being used to provide insight into the influence of the protein active site on MBP binding. In this presentation, our efforts on utilizing these MBPs for metalloprotein inhibition will be discussed.
4:30 Close of Conference
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Conference At A Glance
Epigenetic Inhibitors: Discovery to Clinic
The Future of Fragments and PPIs
April 21-22
April 22-23
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Short Courses | Wednesday, April 22


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Reviewed Braised Beef Brisket with Onions, Mushrooms, and Balsamic
Jan 6, 2012 in Food Network Community Toolbox on FoodNetwork.com
"Both times I've made this, it was very good the first night, delectable with each reheating. Given the choice between this or a rib roast for Christmas dinner, my husband passed on the rib roast. It's that good."""
Reviewed Pulled Pork
Jan 6, 2012 in Food Network Community Toolbox on FoodNetwork.com
"I've made this twice, and it was a hit both times. The 2nd time around I used very dark beer, which really added depth of flavor. For the sauce, I added generous amounts of the braising liquid, which raised the heat level as well as tempered the vinegar bite a bit. But wow does that sauce almost knock me out every time I lean over the stove lo..."


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Seattle Seahawks tight end Anthony McCoy tore his Achilles and is placed on injured reserve for the second consecutive year.
McCoy has torn his Achilles each of the past two seasons.
"It's just a real heartbreaker," Seahawks coach Pete Carroll said. "He's worked so hard to get back."
The Seahawks signed wide receiver Ronald Johnson today.
Johnson played at USC. He has previously played for the Philadelphia Eagles and San Francisco 49ers.
Follow me on Twitter: @RavensInsider
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King James Version (KJV) | New International Version (NIV) |
15 And let them be for lights in the firmament of the heaven to give light upon the earth: and it was so. | 15 and let them be lights in the expanse of the sky to give light on the earth." And it was so. |
The King James Version is in the public domain. (The King James Bible Version Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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PROTECT IP Act Follows In COICA's Footsteps
Re:Time to move search engine companies (162 comments)
Exactly. Why should a non-american trying to search a access *outside* the U.S., limited to a list of sites approved by the U.S. law? Just because he's using an american search engine?
This sucks. It seems it wasn't enough for the U.S. to destroy the global economy, they want to destroy the internet, too?


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Bail for stock theft accused
Comment on this storyTheunissen - Ten men accused of stealing livestock worth more than R580 000 appeared in the Theunissen Magistrate's Court on Thursday, Free State police said.
Sergeant Ian Gaobepe said the matter was postponed to February 28.
The men are Maketola Radebe, 42, Senzile Jonta, 46, Ntsie Matlabe, 48, Lefu Ramathe, 16, Nzimine Mboya, 47, Vencont Malunga, 31, Jack Matheane, 30, Tetemane Mboya, 18, Friedrich Crots, 51, and George Coetzee, 43.
Gaobepe said a witness saw men loading 91 head of cattle into two trucks on Wednesday morning and called the owner, Sello Mokotedi, who alerted the police.
Coetzee and Crots were released on bail of R10 000 each. The others were released on a warning.
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Sarune Zurba
In love with photography since15 years. Love the freedom which it gives,the people which it brings, the routine which is never the same,
Find me at: http://www.sarunezurba.com
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The Hotel is all you need for your pilgrimage!! Situated just next to the Miraculous Chapel of Apparitions and at the Center of tourism in the North part of the Shrine. Has good breakfast for 3 stars hotel and a good daily menu with choices. But what impressed me what that, after reserving the hotel online and asking about parking... More
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Andy Bockelman: 1st 'Breaking Dawn' segment nears 'Twilight' conclusion
Wednesday, December 7, 2011
Movie at a Glance ...
"The Twilight Saga: Breaking Dawn — Part 1"
2.5 out of 4 stars; 117 minutes.
Starring: Kristen Stewart, Robert Pattinson, Taylor Lautner and Peter Facinelli.
Now playing at the West Theatre and at Steamboat Springs' Carmike Chief Plaza 4.
At one point or another during pregnancy, every expectant mother jokes that the new life growing inside her is trying to kill her.
In "The Twilight Saga: Breaking Dawn — Part 1," this mommy is right on the money.
The time has come at last for the wedding of Bella Swan (Kristen Stewart) and her vampire soul mate, Edward Cullen (Robert Pattinson). As preparations are made for her to walk down the aisle, Bella can't help but marvel at what the future will hold, a baffling concept since the phrase "Till death do we part" will have no significance once Edward brings her into his family as a bona fide vampire, with immortality only one of the perks.
A honeymoon on a private South American island sets the tone for an amazing life together. That is, until an uninvited guest changes everything.
When Bella discovers she's pregnant only days after their wedding night, Edward realizes they've created something entirely new: a creature that comes into the world as a vampire.
With the unborn child already draining Bella's life force from the inside the couple is forced travel back home for medical help, but the danger is even greater back in Forks, Wash.
Despite protests from Bella's spurned ex-boyfriend and shape-shifter Jacob Black (Taylor Lautner), the members of his wolf pack insist that the new life that's about to come into the world must never see the light of day, leaving their truce with the Cullens up in the air.
Stewart's never seemed entirely at ease playing Bella, relying more on aloofness and facial expressions than digging in for the role that has made her a star. At least she can finally put those anguished looks to good use as she starts to resemble a frail Mia Farrow in "Rosemary's Baby," unsure what might pop out of her and if she'll even survive.
Pattinson also has a better grasp on his character, feeling extreme guilt over his whole wedding, terrified at the prospect of bringing pain to his new wife and shamed at providing the DNA for the unseen thing that's sucking her dry.
And you dads thought you had it rough for nine months.
Lautner manages to keep his shirt on long enough to have some good moments as Jacob, who swears his allegiance in protecting Bella from his furry kin while still being at odds with the vampire household where she's holed up.
While certain cast members like Ashley Greene — who can't get enough screen time as Edward's clairvoyant sister Alice — are downplayed, some of the red-eyed Cullen actors get more of a focus than they have in previous installments, such as Edward's surrogate parents Carlisle and Esme (Peter Facinelli, Elizabeth Reaser), and burly older brother Emmett (Kellan Lutz). Nikki Reed is at her best yet as sister Rosalie, who's never cared for Bella but suddenly takes a great interest in her.
Or at least her uterus.
The penultimate "Twilight" film is one of the bloodiest so far, though not beyond what's going on in Bella's belly or in her nightmares. With Edward's clan's vegetarian leanings, you knew that already.
By now, viewers have come to expect that teen drama is the best action we can expect from these movies, with the possible exception of a vampire/werewolf showdown. And, what could be more dramatic than an unplanned pregnancy that could herald a new age in vampirism?
For something that so many Twi-hards have been looking forward to, the whole wedding scene blows by faster than you'd expect. If you considered William and Kate tying the knot to be overhyped, just wait.
Plus, the doozy of a wedding night is downright ludicrous once you see the couple's bedroom looking like a tornado went through it. The subtext behind the pseudo-debate about abortion isn't exactly fleshed-out either, but you have to pick your battles.
At least "Twilight" fans will enjoy seeing everything come to fruition, romance-wise before the big finale. Hey, you knew going into it that it's a series strictly for the fans.
The downside — or upside, depending on your taste — of "Breaking Dawn — Part 1" is knowing that there's another part of "The Twilight Saga" coming. Imitating the cliffhanger of the seventh "Harry Potter" movie is a good move in terms of story, even if one deathly pale man at the end of one film is vastly more intimidating than three in another.
Now playing at the West Theatre and at Steamboat Springs' Carmike Chief Plaza 4.
Click here to have the print version of the Craig Daily Press delivered to your home.
More like this story
TwiHARD13 3 years, 1 month ago
I guess this was supposed to be a review? Either you didn't go see the movie before you reviewed it or you just didn't pay attention. I have no problems with differing opinions- everyone has one. However, if you're going to review a film as wildly popular as one of the Twilight Saga films, WATCH THE MOVIE FIRST. Your information is all wrong. Bella and Edward had a half human-half vampire child. She was not a "creature that came into the world as a vampire". Also, Jacob was never Bella's boyfriend... ever. They've always been just friends. However, MOST importantly... the Cullens don't have red eyes. They're golden. That is one of the BIG details of this saga. Newborn vampires have bright red eyes until their choice of diet changes them. If they choose to consume human blood, they will change to deep crimson after a few months. BUT.... if they choose a diet of animal blood, they will change to a topaz/golden/amber color. AS ARE ALL OF THE CULLEN'S EYES... unless they're thirsty, then they're black. So, get your facts straight before you review another movie... especially one of this calibre. K. Thanks. :)
Tammy2 3 years, 1 month ago
Holy crow!!!! A few details about a crappy movie were gotten wrong. HOW WILL I GO ON WITH LIFE!?!?
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Hubby and I have settled on a Toro Recycler 20332 at Big Orange and we were wondering if there are any coupons or discounts offered anywhere for this mower? Anybody ever gotten a discount or larger warranty when buying a Toro mower from Big O or the dealer? Any help appreciated. |
Follow-Up Postings:
Never heard of big orange. Dealers will typically meet the box store price on models like the Recyler series made for box stores. When I bought a Toro I was focused on the long term so quality of build, durability,, quality of operation etc., were of primary importance. It was for those reasons I bought a Toro Super Recycler from a dealer and he offered $50.00 off list. 6 years after the fact I'm not sure exactly how much I paid - but the mower does a great job. There's a message in my message... |
I think she is referring to Home Depot as big orange. Toro generally offers discounts in the spring, they are better on the higher end Super Recycler which the great orange menace does not carry. H-D may offer additional perks with their card. |
Go to the post office, get a change of address kit and inside will be a Lowe's coupon 10 or 20 % I forget. Then, take the coupon to agent orange and they will accept it. |
- Posted by debra_boston Zone 5 - Boston (My Page) on Wed, Mar 24, 10 at 22:12
Tomplum: You Rock! Did zactly what you said and we got $36 back! |
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I am trying to start some grapevines from cuttings and I keep seeing several different how to's but just not sure one says cut-rooting hormone-stick in the ground- keep moist- (fine in cold weather just let them do thier thing) the other says cut-rooting hormone- wrap in napkin- wet- bag in fridge- pull out later- callous and roots should be there done then the next one is put in a jar of water and wait till roots form then the final way cut-rooting hormone- wrap in napkin- wet- put in a warm area (70-90) keep wet and then should root. now my problem is who do I believe what works best now our current temps outside at night is mid 30's and durring the day its between 50-60's and sunny out side. So what I have done is I took the cuttings trimmed them down to the proper size I did strip a little bit of the bark off the bottom of the cutting (exposing the green cambium (i believe that is what it is called) and put the bottom 2 inches in the water and then dipped them into rooting hormone and I put them in a pot of potting soil then I watered the potting soil then I split up the plants half went outside in a sunny area on a table (at night I cover them with other pots to keep them a little protected at night) and the other half went into an old clod frame greenhouse (it is not in the best of shape a hole in the back where the seam of the vinyl cover split a little bit but they are slightly in a protected area) but I just am not sure if that is ok or not because I hear other people saying keep them protected and in temp's in the 70-90 area clearly they are not in those temps outside in the greenhouse durring the day they get into the low 70's but thats it so I just want others opinions on if they will be ok outside with my temps I got 40 cuttings out there and really dont want to loose them. I keep thinking they should be ok because alot of methods have the cuttings in the cold like the keep in the fridge for storage basically I got them in a natural fridge and as the weather heats up they should grow right i dont know help Oh they are Concord's Catabawa's Crimson's Temperano's |
Follow-Up Postings:
I don't know what zone you are in but here in zone 5. I wait till late Febr. then I take hard wood cutting while they are dormant about 5 to 7 inches. Prune bottom end at a angle below a nod,dip in rooting hormone powder, make a hole for each cutting and put in moist sand at least 1/2 way or so and put them in a cool room or cave for the callous to form. Then when late March or early April I put them either in the ground with protection from the sun or in pots of potting mix or I mostly use sand perlite, and cover with plastic, but put in some props of some sort to keep the the plastic from touching the cuttings. keep out of the direct sun keep moist, but not wet and usually by May I've got top growth and I DON'T do the tug test just to see if there is resistance for proof of root growth. i'll find out by middle of June I carefully dig them out and pot up. Not all root, but most times I have at least 80% that do. What zone are you in? and the last two Muscadine varieties ? |
Am I reading most of these wrong or is it not clearly stated on most bottles of rooting hormone not to use on edible plants. |
I've always used the winter cuttings in the refrigerator method. Never had to ever use rooting hormone on them. Despite that, most commercial auxins (rooting hormones) are either indole acetic acid, indole butyric acid, or naphthalene acetic acid, and would have absolutely no affect on any grapes produced by those vines after they grew. Those statements are one of those general CYA requirements the government places in your way. George |
- Posted by Muscadines978 (email@example.com) on Wed, Jun 25, 14 at 5:48
I specialize in the propagation of Muscadine vines. I usually use a mixture of 3 part perlite t to 1 part peat moss. I use both a mist system and several Nearing Frames. I have equal success in both methods. Most of my cuttings set roots in about 5-6 weeks. In 8 weeks I pot them. If they haven't set roots in that period of time I pitch them. I usually have about a 95% success rate. Hans www.MuscadinesAndMore.com |
Here is a link that might be useful: Muscadines And More
- Posted by Muscadines978 none (firstname.lastname@example.com) on Wed, Jun 25, 14 at 5:54
Hi Guys, I had a special order from a lady who wanted 125 small grape vines this last May. She contacted me last Nov. and told me that no one else would grow them for her, so I accepted the order. Last Dec. I took about 400 cuttings, dipped them in Dip-N-Grow and filled a bunch of 1 gal containers with composted hard wood mulch. I stuck 25 cuttings per pot and then dug several trenches in one of my raised beds. Then I placed the pots in the trenches each one touching . I covered them with soil and left them alone all winter. In the beginning of April I dug them up and potted them having about a 99% success. A month later the lady picked them up, all 125 at an easy $4.00 per plant profit. I still had a bunch more small vines to sell. We were both happy!!! |
Here is a link that might be useful: Muscadines And More
Got a questions for Muscadines987 . What zone are you in? When you put the 25 cutting in each pot about how long were the cuttings? Were they in bundles and completely under the medium? Horizontally or vertically? Or How deep into the medium? If not buried How many buds below the medium or how many buds above did you strive for? What was the diameter of the pots? Then when you covered them with soil I take it the cuttings were then completely covered over and about how much soil above the cuttings if any? When you dug these up was it before any buds started to swell? and what kind of grapes did she want? |
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On Tue, 2006-07-04 at 03:51 +0700, Patrick Shirkey wrote:
That does not explain why the authors signed an NDA. I think it is more
likely that the "mystery company" had a (possibly vague and unlikely to
hold up in court, but what free software author could afford to take it
to court anyway) patent on some technique used by LinuxSampler, and
threatened them with a lawsuit if the authors didn't make sure that
LinuxSampler couldn't be used by some commercial competitor to the
mystery company, and promised not to mention anything about the whole
> [snip]
But we are still here!
Lars Luthman - please encrypt any email sent to me if possible
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LINUX® is a registered trademark of Linus Torvalds in the USA and other countries.
Linuxaudio.org logo copyright Thorsten Wilms © 2006.
Hosting provided by the Virginia Tech Department of Music and DISIS.


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Ho, ho, ho!
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text:
Complete Jewish Bible (CJB) | New International Version (NIV) |
1 Yo'ash was seven years old when he began his reign, and he reigned forty years in Yerushalayim. His mother's name was Tzivyah, from Be'er-Sheva. | 1 Joash was seven years old when he became king, and he reigned in Jerusalem forty years. His mother's name was Zibiah; she was from Beersheba. |
Complete Jewish Bible Copyright 1998 by David H. Stern. Published by Jewish New Testament Publications, Inc. All rights reserved. Used by permission. (The Complete Jewish Bible Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


text:
Lower Gauley River Trip
by Chris Russell
Gauley Season begins when the Summersville Dam gates are opened in the fall to take the lake's water reserves down to winter pool levels. For COP boaters it is a chance to test their skills on Class IV water and catalog a new set of misadventures/adventures to share around the campfire.
The season began on the weekend of September 11 with a well run trip lead by Jim and Janice on the Lower Gauley River.
Here are a few photos of the adventure portions, the misadventures ( mostly experienced by a somewhat less than Dynamic Duo in a whitewater tandem kayak) required the attention of all hands working ( in tandem) to collect the runaway boat, gear and bodies hurtling downriver. The first photo shows Jimi Nixon hand paddling his way over a small waterfall at Rocky Top Rapid. Other photos include the Dynamic Duo with their heads above the water and and an adventurous Ben Harder disappearing into a hydraulic in Junkyard Rapid. |


text:
Synolocker 0-Day Ransomware Puts NAS Files At Risk
Re:What a load of FUD! (150 comments)
There is however the constant Nag from Synology to upgrade to the latest versions that system automatically kicks out to you along with the emails they send about the current patches that they recommend you apply to your system. No one auto-patchs NAS devices as bad things can happen to peoples data.


text:
16 May 2007 – Village Pothi, Block Punpun, District Patna
Arvind Kumar, student, 15 years: "In schools, girls are being forced to do work like washing clothes and dishes." Santosh Kumar, student, 14 years: "Poor children are not treated nicely by teachers. They are beaten up. That's why parents do not send their children to the school." Satyanarayan, villager: "Government cares about rich kids, not the poor ones." |


text:
choosing A too often made B a better bet. When A's payoffs dropped, some players noticed right away and quickly switched to choosing B more often. But others stuck with A, gambling that it would return to its previous high-payoff rate. It appeared that some brains are more inclined to take risks than others—some players play conservatively; others are risk-takers. (Actually, Montague said, more accurate labels for the two types of players would be "matchers" and "optimizers." "I call them conservative and risky because you can make good jokes about that," he said.)
To me, it sounds more like they should be called "switchers" and "stickers." But the labels don't really matter. The most intriguing result from this experiment is the revelations from the brain scans. Sure enough, patterns of brain activity differed in the two groups, particularly in a small clump of brain cells called the nucleus accumbens. It's a brain region implicated in drug addiction, and it's more active in the "risk-taking" game players (the stickers).
The neatest thing, though, is that you can tell who the risk takers and play-it-safers are from their brain scans just after the very beginning of the game, even while their behaviors are still identical. This is the sort of evidence that destroys the old behaviorist position that behavior is the only thing that matters (or that you can know). Early in the game, two players can behave identically, making exactly the same choices. Yet by looking into their brains you can see differences that allow you to predict how they will play later, when the payoff rate changes.
"The people that ended up on average being risky are different from these people right away—nobody even jumps categories," Montague told me. Even more intriguing, there appears to be a genetic difference between the two groups as well.
So neuroeconomics thus offers economists a tool they had not possessed before, giving hope that by getting inside people's heads, science might really be on the road to finding the Code of Nature that governs human behavior.


text:
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text:
Rate Dr. Jeffery A. Passer
Dr. Jeffery A. Passer's Ratings
This is a very busy office so they aren't super social. Not a lot of warm and fuzzy stuff going on. However they weren't unfriendly. I am not going there to socialize so it doesn't bother me. I have yet to see Dr a Passer but saw his APRN Tina on both of my visits and my next scheduled as well. She is great. She has taken me off of Synthroid and my synthetic Hormones. Put me on Nature-throid and bioidenticals.. I feel like a new person and am so grateful to this office. The only negative is I waited over 45 minutes but it is worth the wait in my opinion.
Was this rating useful? 0 [[ userState['ratings'][2466640].votes_count ]]
I am so happy I found Dr. Passer. He helped me when other doctors refused to even order simple blood tests and told me I was crazy. Dr. Passer ran tests and diagnosed me with underactive thyroid as well as other hormone imbalances. His treatments are natural and have made a huge impact on my daily life and wellbeing. He is easy to talk to and always treats me with respect! I'm a cash patient and they always work to keep my costs down while providing the best treatment.
Was this rating useful? 0 [[ userState['ratings'][2466639].votes_count ]]
I loved being a patient at Dr. Passer's office, but unfortunately my job required me to move out of state. I called the office to ask what I should about getting my records to a new doctor (-I had never done this kind of thing before, didn't have the first clue). I was transferred, and left a voicemail. That same day the office manager Kelli called me back expressed how sorry she was that I had to leave, but said she would be more than happy to copy my file for me, or fax it directly to another doctor's office, I picked up a copy the next day!
Was this rating useful? 0 [[ userState['ratings'][2137038].votes_count ]]
I have been a patient with Dr. Passer since 1996. I have been very faithful and not only do I receive a smile and friendly greeting from staff but Dr. Passer as well. He has always been there and would not consider anyone else for my Primary care Dr. Not only is he kind helpful and very knowledgeable in all but a few areas and if he doesn't know he does advise to who and where to find the specialized field only recommending the best Doctors in that field. Even when the office is busy Dr. Passer comes in with a smile handshake and says and makes the right choices for whatever the condition is. Living some distance away it has always been worth the drive and would highly recommend and never consider anyone else. Thanks you Dr. Passer for your sincere excellence I only hope that you able to help me for years to come.
Was this rating useful? 0 [[ userState['ratings'][2137036].votes_count ]]
I have been a patient of this clinic for six months. I have had two visits and many other interactions via telephone. I have seen the Physician Assistant both times. She is pleasant and knowledgeable in person, but at times can appear rushed. I was very pleased with the initial results I got from this clinic. I also feel their supplements are wonderful products, and have positively contributed to improvement in my overall health. The problem with this practice is the support staff. I have unfortunately never had so many negative interactions, even when attempting to be nice on the other end. I initially assumed this was due to a staff shortage, but there has been no change. I don't know how much longer I can take the poor treatment. This would be a wonderful practice if the support staff were positive and had a customer service attitude. I dread calling the office with questions or to schedule an appointment. I have heard the staff talk negatively about other patients while in lab. SAD
Was this rating useful? 0 [[ userState['ratings'][2137035].votes_count ]]
Dr passer was not helpful to me at all. He treated me simply like a number and didn't really care about my well being. I went back to see if it would be different but it was not! I would not reccomebd this doctor to anyone in the Omaha area. I also moved to Texas and when I called to get my records faxed they said they would but didn't.. So when I showed up at my new doctors office( which required my records) they didn't have them which made me have to reschedule my appoinent. Very disappointed with the staff and more in the doctor. Horrible service and didn't care about me as a human being
Was this rating useful? 0 [[ userState['ratings'][2137039].votes_count ]]
The staff is very rude which is why I quit going to Dr. Passer. He even agreed that they are rude and gave me his cell number to call! I did not call. What he was doing for me made no change in my condition. It was a very expensive ordeal for no help. The wait time was very long. Staff ignored me when I checked in to the counter. They were loud and obnoxious, not professional. I should have read these comments before I went. Didn't know so many others had the same experience and also didn't know Dr. Passer isn't well respected in the medical community. I wish I would have saved my hard earned money. I'd like a refund...feel robbed.
Was this rating useful? 0 [[ userState['ratings'][2137034].votes_count ]]
I am new to the Midwest and went to Dr. Passer because he seemed to have an approach to health that I appreciated. I have to say that I have been very disappointed with my experience as his patient over the last two years. The office staff is very rude, almost arrogant. The nurse practitioner who would see me in place of Dr. Passer was not very knowledgeable and did not evoke much confidence from me. I have been very patient - its been two years - because I was hoping it would improve. When I went for my annual physical, the PA suggested that I see a cardiologist but didn't have a recommendation - just told me to look one up. The same when she told me to see a neurologist. Since I had to find my own specialists, I asked about Dr. Passer and discovered tht he doesn't have a good reputation in the medical community. I have now been referred to a highly recommended doctor and will be moving my medical records over.
Was this rating useful? 0 [[ userState['ratings'][2137033].votes_count ]]
I have been going to Dr. Passer for about 2 years now and he has made my thyroid worse. He bases his diagnoses on symptoms not actual levels. At first I thought that was great to have a doctor think outside the box, but now other medical professionals have raised concern on my levels and the amount of thyroid he was prescribing. He was telling me my levels were okay but they were really off! The main thing that I would like to share with everyone considering this doctor is that basing prescription levels on symptoms and not blood tests has really affected my day to day life and I'm afraid it could also affect my long term medical future, and just just my thyroid but heart, and everything else. Please beware. If I could afford it, I would sue him for what he has done to me, just to maybe stop him from doing this to someone else.
Was this rating useful? 0 [[ userState['ratings'][2137032].votes_count ]]


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Northeastern University School of Law
This article appears to be written like an advertisement. (May 2012) |
Northeastern University School of Law | |
Parent school | Northeastern University |
Established | 1898[1] |
School type | Private |
Dean | Jeremy Paul[2] |
Location | Boston, Massachusetts, USA |
Enrollment | 604[3] |
Faculty | 82[3] |
USNWR ranking | 93[4] |
Website | www.northeastern.edu/law/ |
Northeastern University School of Law (also known as NUSL) is the law school of Northeastern University. Located in Boston, Massachusetts, the school was originally founded in 1898 as the Young Men's Christian Association of Greater Boston's evening law program.[1][5] Northeastern University School of Law closed in 1956 but was reopened in 1968.[1]
Today the school enrolls about 600 students[3] and offers Juris Doctor (J.D.) and Master of Laws (LL.M.) degrees.[6] NUSL focuses on experiential education, guaranteeing its students a full year of practical legal work through the school's Cooperative Legal Education Program.[7]
U.S. News & World Report ranked Northeastern University School of Law 93rd in its 2014 ranking of American law schools.[4] According to NUSL's 2013 ABA-required disclosures, 45.4% of the Class of 2013 obtained full-time, long-term, bar passage-required employment nine months after graduation, excluding solo practitioners.[8]
Northeastern University School of Law was founded by the Young Men's Christian Association(YMCA) of Greater Boston in 1898 as the first evening law program in the city.[5] The program was incorporated as an LL.B.-granting law school, the Evening School of Law of the Boston YMCA, in 1904.[5] Additional campuses of the YMCA Law School were opened in Worcester, Massachusetts by 1917 and in Springfield, Massachusetts and Providence, Rhode Island by 1921, although those branches were all closed by 1942.[9] In its early days, the school "saw itself as the working man's alternative to the elite schools" and "boasted of being 'An Evening Law School with Day School Standards,'" using the case method of teaching, according to legal historian Robert Stevens.[9]
The school was renamed Northeastern University School of Law in 1922 and began admitting women that year.[5] NUSL was accredited by the University of the State of New York in 1943 and became a member of the Association of American Law Schools in 1945.[5] However, the school closed in 1956 due to declining enrollment and financial difficulties.[1]
NUSL reopened in 1968 with an emphasis on cooperative legal education.[1] It was accredited by the American Bar Association in 1969.[10]
Cooperative education program[edit]
The School of Law offers a Cooperative Legal Education Program. This program provides all students with a full year of hands-on legal experience gained through four, three-month internships in law offices, judge's chambers and other organizations throughout the world. More than 900 employers participate in the School of Law's program. By completing work placements with four different legal employers, students have the opportunity to experience the actual practice of law and to integrate practical experience with a theoretical foundation of in-depth classroom study. To accommodate this schedule, the academic year for second and third year students is broken into four quarters, with students alternating between classroom instruction and legal internships, in a program that is designed to blend theory and practice and provide students with a unique set of skills and experience to successfully practice law.
Master of Laws (LLM) Program[edit]
Northeastern University School of Law's LLM program offers law graduates from around the world the opportunity to study at the nation's top experiential law school. This hands-on LLM program is unique: based on Northeastern's Cooperative Legal Education Program, the LLM offers qualified students an 11-week, full-time legal practice experience (co-op). The LLM program offers a number of concentrations and dual-degree programs.
Post-graduation employment[edit]
According to Northeastern University School of Law's official 2013 ABA-required disclosures, 45.4% of the Class of 2013 obtained full-time, long-term, bar passage-required employment nine months after graduation, excluding solo practitioners.[8] NUSL ranked 152nd out of the 201 ABA-approved law schools in terms of the percentage of 2013 graduates with non-school-funded, full-time, long-term, bar passage required jobs nine months after graduation.[12]
Northeastern University School of Law's Law School Transparency under-employment score is 38.5%, indicating the percentage of the Class of 2013 unemployed, pursuing an additional degree, or working in a non-professional, short-term, or part-time job nine months after graduation.[13] 82.6% of the Class of 2013 was employed in some capacity while 0.9% were pursuing graduate degrees and 14.7% were unemployed nine months graduation.[8]
Massachusetts was the primary employment destination for 2013 NUSL graduates, with 70% of employed graduates working in the state.[8]
The total cost of attendance (indicating the cost of tuition, fees, and living expenses) for first-year students at Northeastern University School of Law for the 2014-2015 academic year is $64,717.[14] The Law School Transparency estimated debt-financed cost of attendance for three years is $238,203.[15]
Other notable features[edit]
The School of Law is recognized as one of the top public interest law schools in the nation. All students are required to complete a public interest co-op, and many students participate in the school's clinics and institutes, such as the Civil Rights and Restorative Justice Project,[16] which are dedicated to challenging existing boundaries of law in pursuit of economic and social justice. In addition, all students are required to complete a year long social justice project during their first year. Graduates of the School of Law enter public interest careers at a rate three to five times the national average for all law school graduates.
The Princeton Review's "The Best 172 Law Schools" ranks Northeastern #2 among all the law schools for both providing the "best environment" for minority students and for having the "most liberal" students.
Northeastern is one of the top 10 "Most Diverse Law Schools" according to The National Jurist.
Northeastern is one of the "Top Five Overlooked Law Schools" in the nation according to Above the Law.
WorldWideLearn, an online educational resource, says the Northeastern law website is among "20 Law School Websites That Set the Bar High."
The law school publishes an award-winning magazine, Northeastern Law Magazine
- Mary Bonauto, Civil Rights Project Director, Gay & Lesbian Advocates & Defenders; lead counsel in Goodridge v. Department of Public Health
- Dana Fabe, Chief Justice, Alaska Supreme Court
- Maggie Hassan, Governor of New Hampshire
- Janet Bond Arterton, Judge, United States District Court for the District of Connecticut
- Margot Botsford, Justice, Massachusetts Supreme Judicial Court
- Landya McCafferty, US District Court Judge for the District of New Hampshire
- Leocadia Zak, Director, US Trade and Development Agency
- Andrew Glincher, CEO and Managing Partner, Nixon Peabody
- Timothy Mark Burgess, Judge, United States District Court for the District of Alaska
- Marie-Therese Connolly, Elder Rights Lawyer, Recipient of 2011 MacArthur "Genius" Fellowship
- William "Mo" Cowan, US Senator (retired); Chief Operating Officer, ML Strategies
- Martín Espada, poet
- Delissa A. Ridgway, Judge, US Court of International Trade
- Rishi Reddi, short story writer
- Courtney Hunt, Best Picture Academy Award-nominated film director/screenwriter in 2009 for Frozen River
- Robin Kniech, Member, Denver City Council
- Victoria A. Roberts, Judge, United States District Court for the Eastern District of Michigan
- Dorothy Samuels, Editorial Writer, New York Times
- Judith A. Scott, General Counsel, Service Employees International Union SEIU
- Mary T. Sullivan, Justice, Massachusetts Appeals Court
- Urvashi Vaid, LGBT rights activist
- Kumiki Gibson, Chief Counsel to Vice President Al Gore (former)
- Peter Franchot, Comptroller of Maryland (former)
- Scott Heekin-Canedy, President and General Manager, [[New York Times] (retired)]
- Leslie Winner, North Carolina State Senator (former)
- Thomas A. Flaherty, (deceased) Member, US House of Representatives
- Harold Donohue,(deceased) Member, US House of Representatives
- John Psatore, (deceased), Governor, Rhode Island; Member, US Senate (representing Rhode Island)
- Francis J. Quirico, (deceased) Justice, Massachusetts Supreme Judicial Court
- ^ a b c d e "History and Mission". Northeastern University School of Law. Retrieved 22 July 2014.
- ^ "Welcome from Dean Jeremy Paul". Northeastern University School of Law. Retrieved 22 July 2014.
- ^ a b c "Section of Legal Education ABA Required Disclosures". American Bar Association. Retrieved 22 July 2014.
- ^ a b "Northeastern University". U.S. News & World Report. Retrieved 22 July 2014.
- ^ a b c d e "Northeastern Timeline". Northeastern University. Retrieved 22 July 2014.
- ^ "Quick Facts". Northeastern University School of Law. Retrieved 22 July 2014.
- ^ "The leader in experiential education". Northeastern University School of Law. Retrieved 22 July 2014.
- ^ a b c d "Section of Legal Education - Employment Summary Report". American Bar Association. Retrieved 22 July 2014.
- ^ a b Bocking Stevens, Robert (1983). Law School: Legal Education in America from the 1850s to the 1980s. Union, New Jersey: The Lawbook Exchange, Ltd. Retrieved 22 July 2014.
- ^ "Alphabetical School List". American Bar Association. Retrieved 22 July 2014.
- ^ "Employment Summary for 2013 Graduates".
- ^ Leichter, Matt. "Class of 2013 Employment Report". The Law School Tuition Bubble. Retrieved 22 July 2014.
- ^ "Northeastern University Profile". Law School Transparency. Retrieved 22 July 2014.
- ^ "Student Expense Budgets".
- ^ "Northeastern University Profile".
- ^ "The Goal: To Remember Each Jim Crow Killing, From The '30s On". NPR. January 3, 2015. Archived from the original on January 3, 2015. Retrieved January 3, 2015.
External links[edit]
- Northeastern University School of Law
- Northeastern University Law Journal
- The Emma Jean Lang Avery papers, ca. 1916-1931 are located in the Northeastern University Libraries, Archives and Special Collections Department, Boston, MA.
- The Samuel H. Becker papers, 1925-1962 are located in the Northeastern University Libraries, Archives and Special Collections Department, Boston, MA.
Coordinates: 42°20′21.15″N 71°5′26.93″W / 42.3392083°N 71.0908139°W


text:
& Deals
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Wanna makes these at home? No problem. Grab a kitchen scissors and a container of Pillsbury refrigerated country Italian bread or crusty French loaf, and you're good to go. Just follow these steps:


text:
Gold Medal 2067M Customer Reviews
Product Code: 231-2067M
KaTom is great. They always have what I am looking for at a great price. I wanted something to use that would be easy and quick to fill with kettlekorn. I was using the 1oz bags but those were difficult to fill and to keep upright. The cones were easy to fill. It was a challenge to find a way to display them without them falling over. I found a milk carton with holes in it and placed the cones in the holes. This worked great! I could fit about 8 cones in the holes with very little kettlekorn falling out. Customers loved the cones because they could stick their tongues in and get a few kernels without using their hands (that was the actual feedback I got!).


text:
Third Millennium Bible (TMB) | New International Version (NIV) |
13 And the LORD said unto Moses, "Rise up early in the morning, and stand before Pharaoh and say unto him, `Thus saith the LORD God of the Hebrews: Let My people go, that they may serve Me. | 13 Then the LORD said to Moses, "Get up early in the morning, confront Pharaoh and say to him, 'This is what the LORD, the God of the Hebrews, says: Let my people go, so that they may worship me, |
Third Millennium Bible (TMB), New Authorized Version, Copyright 1998 by Deuel Enterprises, Inc., Gary, SD 57237. All rights reserved. (Third Millennium Bible Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


text:
Book your room at Hotel Kyriad Rouen Centre
Triple Room: 3 single beds
Max Occupancy: 3 guests (up to 2 children, 1 infant)Double Room
Max Occupancy: 2 guests (up to 1 child, 1 infant)Triple Room: 1 Double & 1 single bed
Max Occupancy: 3 guests (up to 2 children, 1 infant)Twin Room
Max Occupancy: 2 guests (up to 1 child, 1 infant)Rouen hotel with a restaurant
Situated in Rouen, this hotel is close to University of Rouen, Jeanne d'Arc Church, and Place du Vieux-Marche. Also nearby are Gros Horloge and Rouen Cathedral.
Hotel Features
In addition to a restaurant, Hotel Kyriad Rouen Centre features a bar/lounge. Other amenities include dry cleaning/laundry services and conference space.
Room Amenities
Televisions come with cable channels. Guestrooms also feature air conditioning, climate control, and coffee/tea makers.
Information missing or incorrect? Tell us!


text:
Developer Loses Single-Letter Twitter Handle Through Extortion
All right, I'll bite. (448 comments)
I will assume since it hasn't come up already that there is some reason Twitter can't just give him back the handle. What is it?
Announcing: Slashdot Deals - Explore geek apps, games, gadgets and more. (what is this?)
We are sorry to see you leave - Beta is different and we value the time you took to try it out. Before you decide to go, please take a look at some value-adds for Beta and learn more about it. Thank you for reading Slashdot, and for making the site better!
All right, I'll bite. (448 comments)
I will assume since it hasn't come up already that there is some reason Twitter can't just give him back the handle. What is it?
Waste of time (337 comments)
You can't raise the threshold high enough to weed out the stupid ideas because a lot of them are popular - the Texas succession petition got 125k. That said, the petition system was never going to be useful in the first place, so at least we're not using anything valuable.
Re:is it real (1198 comments)
That's why when I mug somebody in the US, I make sure to shoot them first.
Moria 2.0 (269 comments)
Construction will have to be stopped after they dig too deep and release the Balrog, though.
I wonder... (259 comments)
How long are we going to be using the phrase "worst nuclear disaster since Chernobyl"?
Oops (299 comments)
The final components will be accidentally dropped Tuesday at the Amarillo Crater...
The obvious name... (239 comments)
Well, somebody has to use the Quikster name, might as well be them.
Re:Excellent (111 comments)
Nobody with any sense complains about embryonic stem cells either, just the people who think humans can be single-celled organisms.
Re:as a European. (1040 comments)
Everybody knows the explosion of the deficit has nothing to do with Obama
No. No they don't. There are a lot of people trying very hard to prevent everybody from understanding the actual problems, and they're doing a pretty good job of it.
Re:Maximize profit (591 comments)
Joel Spolsky pointed out the problem with this a few years back: http://www.joelonsoftware.com/articles/CamelsandRubberDuckies.html When your unit production cost is small, you're better off (as much as possible) to adjust the price based on the ability of the consumers to pay and get something out of the poorer ones instead of nothing.
Re:Not only the carriers, also the NGO's (235 comments)
My grandfather always used to tell me that he would die before he ever gave to the Red Cross. When he was in Korea, the Red Cross used to show up and sell soldiers coffee and donuts (at a profit, no less). No money meant no coffee and donuts for you, G.I.
I'm not disparaging their work (I don't know enough to comment on that). I'm just saying that they need to be much more upfront with people about where their money is actually going.
Ten seconds on Snopes; http://www.snopes.com/medical/emergent/redcross.asp
There is truth to one of the rumors, however. During WWII the American Red Cross did indeed charge American servicemen for coffee, doughnuts, and lodging. However, it did so because the U.S. Army asked it to, not because it was determined to make a profit off homesick dogfaces.
Re:MPG Difference Explained (417 comments)
Woo, 10.5 feet per gallon.
Re:Cracked! (306 comments)
That's not the point. You were already allowed to see the image. What it tries to reduce is the ability of someone unrelated to find it n years later. You had to remember to save a copy at the time. Unfortunately, you're probably more likely to do so if it's an interesting picture.
It's not useless, and it's not perfect. Not a terrible idea though.
Hmm... (306 comments)
Sounds great, but the more interesting/risky/incriminating/etc the picture, the more likely it is that someone's going to keep an unencrypted copy around, no?
Re:What, exactly, is 3-SAT? (700 comments)
Romanes eunt domus.
Re:Yay, more Input Lag (202 comments)
Only in the future would you care about having 60,000 fps, though.
Re:Next step... (570 comments)
Was there any evidence you could have provided that would have provoked the response "Oh. I guess it's not true after all"?
Re:Vote or Die (836 comments)
Nothing happened yet. You will get all of those things eventually because McCain didn't win, die after 3 months in office, and have Palin start WWIII.
Or maybe you won't. But please don't confuse "Obama isn't perfect" or "Obama is flawed" or "Obama has serious problems" with "Obama is worse than the alternative."
Just to pre-empt it... (408 comments)
No, this does not get you down to a 6000-year old Earth. Sorry.
Re:Depends who you thnk teachers work for (629 comments)
The funny thing is, you sound exactly like the people who want to impress toxic social morals on their kids.