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Ratings based on 101 Verified Reviews
They paid and stayed. We double-checked.
4.3 Room cleanliness
4.4 Service & staff
4.2 Room comfort
4.2 Hotel condition
They paid and stayed.
We double-checked.
We double-checked.
for Everyoneby A verified traveler
Great mid-priced motel
Posted Jan 16, 2015Pros: Convenient location, good amenities for the price. Friendly staff and a full breakfast, not just continental.
Cons: Hard to think of anything immediate; not much to complain about.
Location: Near plenty of shopping, Olive Garden, gas stations and very easy to get downtown or whereabouts. Decent museum and art gallery + local eats.
Stayed for some January eagle watching and weekend Ice Fest. Fairfield showed highest rating in the group and is reasonably priced.
for Everyoneby A verified travelerfrom wisconsin
Parents weekend
Posted Nov 3, 2014Very nice hotel for the money except we found a dirty q-tip in the drawer the breakfast was great and the facilities were nice
for Everyoneby A verified traveler
location distance to casino was about twice as far
Posted Oct 28, 2014Room# 200 trouble with air conditioning temp was about 75 could not get it to run the fan to cool room, extra $5 charge for internet service was a unpleasant surprise.
for Everyoneby A verified travelerfrom Mpls
Convenient to downtown and Galena
Posted Oct 20, 2014Pros: The pool, breakfast, beds, and location
Location: We went to the aquarium, very nice!
The room was clean. The bathroom was a little small. The pool area was in good condition. The breakfast was fine. The internet was a little slow, they sell an upgrade for faster internet, boooo. All together a pleasant place to stay, Olive Garden right next door and Target very close were convenient.
for Everyoneby A verified travelerfrom KC MO
Awesome Staff!!!!
Posted Oct 17, 2014Pros: Great Staff... Great room .... Tasty Breakfast!
Cons: Keep up the good work!
Location: Bicycle trail nearby... I need to check it out further.
This was the first time I stayed here... will not be the last
for Familiesby William l. Taylorfrom Burlington, Iowa
Watch Out When You Pay
Posted Sep 30, 2014 on Hotels.comThe room was fine. Paying for it was another matter. Paid cash, which included all charges, at the desk when we checked in. Left the next day. Got home and discovered my debit card had been hit for what I paid plus more by the hotel. That put me in an overdraft status. Called; manager said that's just how it's done. She also said it's normal for a hotel to tack on an extra percentage to the bill. She couldn't say why, when I paid on Sat., that the charge was run through on the day we left. Said the charges would "drop off' in a couple of days, which, again doesn't help the overdraft situation. Don't they have a night auditor that could have prevented this (if someone alerted them)? Is it really just "normal" and they're helpless to stop it from happening? I don't think so (neither did my bank).
Comment from Hotel Management
Jan 3, 2015 by Manager, Hotel Management
Dear Mr. Taylor, Thank you for your review. I'm very sorry for the negative experience you had at check in and for the stress it caused you. As I explained to you over the phone, when you check in we do authorize your card for the amount of the stay plus any incidentals you may incur to ensure the funds are available. We can bypass this for our guests paying in cash if they notify us ahead of time. Unfortunately, we had already swiped your debit card when you told us you wanted to use cash. At that point there is no way to undo this action, which causes the funds to be put aside by your bank. It varies between banks as to how long it takes for these funds to be made available to you again. Once again, I'm very sorry for the trouble this caused you, and I hope that you will allow us another chance to earn your business. Sincerely, Connie J. General Manager
for Everyoneby A verified traveler
Posted Sep 2, 2014
The beds are so comfortable, they'll make you late for check-out! Great facility and incredibly clean.
for Everyoneby A verified travelerfrom Wausau, WI
Great hotel
Posted Sep 2, 2014Pros: Breakfast and pool
Cons: Nothing
Location: Sister in law
Love our stay, very comfortable room, great breakfast and enjoyed using the pool and whirlpool.
for Everyoneby A verified travelerfrom PA
Nice hotel on the main drag of Dubuque.
Posted Jul 31, 2014Pros: Friendly staff, good location, easy access.
Cons: Marriott does a great job.
Chose this hotel on a visit to a family member. Easy access to all areas.
Comment from Hotel Management
Aug 1, 2014 by Manager, Hotel Management
Dear Guest, Thank you for reviewing your stay at the Fairfield Inn Dubuque. I'm so glad to hear that you enjoyed our convenient location and friendly staff. We hope to have the opportunity to host you on your next trip to Dubuque! Sincerely, Connie J. General Manager
Recommendedby Andy Bfrom NJ
Very comfortable stay
Posted Jul 22, 2014 on Hotels.comI booked two different hotels for a recent trip to Dubuque. This was one of them. The room was clean and comfortable and the staff very friendly. Breakfast was a notch better than I would have hoped for, and they offered me cookies and a cold bottle of water when I checked in. I would recommend the hotel. The only drawback to me was that it seemed to be a little expensive for the area.


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Here is the news: now pick and choose what you want to believe
Sometimes news items appear in the media that seem to have no connection with reality. Indeed, so unprepared are we for the way they drastically cut across conventional wisdom that we have to leave them alone, in the hope that they will go away as mysteriously as they arrived.
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High school football: Bingham coach shared championship ring to help players understand the ultimate goal
SOUTH JORDAN — When Bingham head football coach Dave Peck called Mahonrai Toki's name, the senior wept.
When he called on Chandler Wahlstrom, the linebacker couldn't speak.
Vaka Vehikite was simply shocked that his coach would trust him that much.
"I thought, 'He must love us to death to let us take his (state championship) ring home, and let us do whatever we want with it," said Vehikite. "It just shows how much Coach Peck really loves this team, how much he trusts this team."
Peck is one of the few coaches who will admit to discussing on a daily basis the dream nurtured by most high school athletes — winning a state title.
"A lot of coaches will say, 'Take it one week at a time,' and to a point, that's great," Peck said. "But you have to have that ultimate goal in mind. It gives you something to strive for. Our goal was to get ready to play in the state championship game every week, to be the best team in the state every week."
Instead of banning talk about state championships, Peck encourages it.
But as he talked with his players throughout the grind of spring weightlifting and the monotony of summer conditioning, he realized that a state title might be one of those things one had to experience to understand.
It was in trying to find a way to help his players understand the special joy of a state title that he decided to do something that shocked his players.
"Every week I give a different person my 2006 state championship ring," Peck said. "I tell them that other than my kids, it's my most precious item. ... I think it became a trust issue, as well. Some of them wore it all week. Some of them kept it at home in a trophy case. But they all got up when I gave it to them and said what it would mean to them to be a state champion."
When Vehikite saw the young men Peck was entrusting the ring to, he thought the honor would never be his.
"He even said, 'I never thought I'd give this kid my ring, but he deserves it,'" Vehikite recalled. The senior linebacker said he didn't feel worthy to wear it, so he kept it in its case at home.
"I didn't feel worthy to wear it because I'm not a state champion myself," he said, adding that he felt different just having the ring in his possession. "You feel like you have to step it up a notch because Coach Peck is a state champion coach, so you have to play like a state champion."
Toki, a 17-year-old defensive end, said he broke down when his coach asked him what inspired him.
"I started bawling," he said. "He asked me what drove me, and I told him it was my mom."
Toki's father has been hospitalized for two months with Crohn's disease, and his mother, Sela, has had the responsibility of caring for her seven children alone.
"She's really strong," he said.
He didn't plan to wear the ring much, but changed his mind once it was entrusted to him.
"I ended up wearing it every day," he said smiling. "Just because it was awesome." Most of the boys said they felt different with the ring in their possession. Nick Heninger, a senior outside linebacker, was the first to be trusted with it.
"You have to know what you're working for every week," he said. "And it's a state championship that we're working for."
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Date: 1918-12-22
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FIFA 12 takes top spot in UK chart
FIFA 12 is the new number one in the UK all-formats software chart, as last week's number one Gears Of War 3 drops back to second place.
EA's football title enjoyed the third-biggest launch week in history, beating FIFA 11's launch-week sales by 11 per cent, outselling Grand Theft Auto IV and beaten only by Call Of Duty Black Ops and Modern Warfare 2.
This week's top ten contains only one other new entry, with Sony's PS3-exclusive Ico & Shadow Of The Colossus Collection a pleasing sight at number seven. Further down, X-Men: Destiny debuts in 18th, with Ubisoft's Dance Juniors in 24th spot, and the PS3 release of Tetsuya Mizuguchi's Child Of Eden entering the chart at number 29.
02. Gears Of War 3 (Microsoft)
03. F1 2011 (codemasters)
04. Zumba Fitness (505 Games)
05. Dead Island (Deep Silver)
06. Deus Ex: Human Revolution (Square Enix)
07. Ico & Shadow Of The Colossus Collection (Sony)
08. Driver: San Francisco (Ubisoft)
09. Lego Pirates Of The Caribbean (Disney Interactive)
10. Call Of Duty: Black Ops (Activision)
Source: UKIE
Chart History


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Mandatory Newsletter
Get a weekly dose of MANDATORY by signing up for our newsletter.
Nothing is safe for children anymore.
From Bryan Cranston to Charlie Sheen, and many more in between.
Here are the best celebrity-cartoon lookalikes.
Even some cartoons come from broken homes.
They deserve some credit.
An elite group of cartoon voices.


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Limited Time Sale - 70% OFF! $2.99 -> $0.99
No. 1 business card scanning app, loved by 100 million users.
* Apple App Store Rewind 2011/2012 Top Business App
* Must-Have Apps for Salespeople - Inc.com
* The
business cards just jump into your phones. It's that easy to use! - CBS TV
* Bringing Order to the Chaos of a
Business Card Collection - The New York Times
CamCard reads and saves your business cards, remembering everyone you meet for business. It is the perfect fit for those who have lots of business cards or who love business social networking.
Cut Card Clutter
Quickly & accurately read business cards and save to your phone.
Exchange E-Cards
Exchange e-cards with contacts via QR Code, Card Radar or Private Group.
Contacts for Business Only
Make a standalone Contacts from your personal one. Make calls, send messages and
locate company address on map.
Personal Profile
Enrich your profile with more information. Your contacts will be notified with every update of
Keep You Posted
Get notifications on any updates of your business contacts. Be the first one to greet them on
their promotions, new jobs or others.
Share Easily
Share cards via email, social network or QR code.
Company News
Get to know your customer's company news instantly. Use it to break the ice and start a good
Lite CRM on your Mobile
Add notes in texts/image format, set reminders for follow-up. Remember every lead's
details to transfer them to a customer.
Manage Contacts on the Go
All your customer information can be synced across your smartphone, tablet and
computer for easy management on the go.
Support 16 recognition languages: Traditional Chinese, Simplified Chinese, Danish, Dutch, Finnish, Korean, Norwegian, Japanese, English, French, German, Spanish, Portuguese, Hungarian, Italian, Swedish, Russian.
Check out INTSIG's other apps
* CamScanner – Document scanning and sharing app
* CamDictionary – Snap
* IS Contacts Kit – Back up all your contact with one tap
We'd love to hear your feedback, email us at email@example.com
Follow us on Twitter @camcardintsig
us on Facebook with CamCard
Follow us on Google+: CamCard
In this update,
1.Optimized app interface & experience
2.Moved Group section to left side bar
3.Nearby Contacts upgraded to Card Radar, meet new friends nearby
4.Optimized Note feature: support image/text
note to keep track of all your communication activities
5.Show all your contacts near your current location in
6.Add additional email addresses and phone numbers to Profile
7.Exchange cards in Private Group via invite
8.Option to keep previous contact information when contacts update their cards
9.Other improvements and
bug fixes
In this update:
1.Optimized app interface & experience
2.Moved Group section to left side bar
3.Nearby Contacts upgraded to Card Radar, meet new friends nearby
4.Optimized Note feature: support image/text
note to keep track of all your communication activities
5.Show all your contacts near your current location in
6.Add additional email addresses and phone numbers to Profile
7.Exchange cards in Private Group via invite
8.Option to keep previous contact information when contacts update their cards
9.Other improvements and
bug fixes
1.Optimize map feature
2.Improved performance and fixed bugs
Perfectly working on iOS 7
All-new look, all-new design for better experience
In this update, we added
- Nearby Contacts: quickly exchange e-cards with contacts on spot
- Company News:
One-tap get more information about new contacts
- Multimedia notes: supporting texts and images
Notifications: get instant notice of contacts' information updates
- View nearby contacts on map
- Quick
dialing and editing options
Optimize card scanning process
Other improvements and bug fixes
- Improve recognition accuracy of email addresses
- Other improvements and bug fixes
1. Add updates push feature for AR Card
2. Optimize batch scanning feature
3. Capture card backside
4. Simplify the process of creating and verifying AR Card
5. Easily search contacts
6. Optimize card
sharing via WeChat
7. Optimize map feature
8. Support VoiceOver
9. Other improvements and bug
Make it easier to group cards, save cards to Contacts
Simplify sharing cards via messages
Add feature
"navigate contact addresses"
Other improvements
1. Your business card can play video now! Record or upload video from phone or via www.camcard.com
2. Link
your LinkedIn profile with AR Card instantly
3. Make your AR Card eye catchy with more templates
4. Easy
connect with others on social media
5. Full-screen viewing mode for faster card browsing
6. Automatically
capture card image(iPhone 4s, iPhone 5)
Brand New AR Card
* Augment Reality technology: add text, graphic, audio, video, files and links to your
business card
* Once your AR Card is created, partners will read your cards 100% accurately with 200+ languages
* Share AR Card via email, QR code and SMS
* Add or edit AR Card in CamCard web app
1. Enhanced Card Info Editing: Recognized text is marked on business card now.
2. Optimized for iOS 6 and
iPhone 5.
3. Bug fixes and other improvements.
✓ Group can be sorted manually
✓ Re-design mass email and SMS
✓ Compatible with more QR codes
Batch save cards to system Address Book. Batch import contacts to CamCard.
✓ Other optimization
✓ Fix
searching bug
Warning: This update version does not support iOS 4.0.x.
Performance is optimized for large quantity of cards.
Synchronization performance is optimized.
Fix other
Backup Cards in Cloud: All cards can be saved in the Cloud securely, privately and never missing a single card.
Restore Card: Restore cards in case of accidental deleting.
Cloud Sync across Multiple Devices: Scan a card with
one device, all updates will be synced across multi-devices.
Enhanced Group Management: Makes it much easier to
manage all cards and groups.
Introduce: Introduce your friends to each other and share cards between them.
Create a card with card templates: when creating a card manually or importing a contact from phonebook, a card will be
created automatically. You can choose from different card templates.
bug fixes
fix the crash problem of iPad2.
improve the performance of the camera
bug fixes of saving contacts to group
bug fixes
Attention: Due to compatible problem, for iPhone 3G, please do not upgrade this time!!!
Batching scanning and recognition
Card Holder Back-up
Generate QR Code from the card image
QR Code business card
Export card informaton to Excel file
Add Email Signature.
1.fix bug of camera in iOS4.1
2.fix bug of the keyboard in zip code input
minor bug fixes
Folder management in cardholder.
Double side business card image capturing.
Improve OCR recognition
Improve the cardholder's sorting & search function.
Share contact's information with Email.
Search contact's information in LinkedIn, send LinkedIn's invitations.
Add password of cardholder.
contact's information to different account.
Bugs fix.
bug fixes in iPhone OS 4
1.Add French, Spanish, Portuguese, German, Italian, Dutch,
Turkish, Swedish, Finnish, Danish, Norwegian,
Hungarian Recognition.
2.Auto extract business card images.
3.Auto beautify business card images
holder management.
5.Merge&Revert with existing contact.
6.IOS 4 bug fixes.
1.Add Group function.
2.Minor bug fixes
1.Add French recognition in app purchase.
2.Add anti-shake function.
3.Improve recognition rate.
1.remove 0 when country code is present in the telephone field.
2.add Portuguese Recognition function through
in app purchase.
3.add Spanish Recognition through in app purchase.
1.Improve the recognition rate, especially for the portrait card.
2.The recognition results are fixed to
match with iPhone Contact.
1.improve recognition speed
2.fix memory leak bugs
1.fix bug when saving photos to album.
2.remove auto adding zero to the start of telephone number.
exception alert when saving contacts to address book failed


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Grilled Tuna with Butternut Squash A delicious, heart-healthy, high-protein meal every guy can master.
Healthy Meals With Only 3 Ingredients The number of healthy meals you can make in minutes with these ingredients is almost infinite.
Recipe: Easy Peanut Noodles with Chicken This easy-to-prepare pasta dish will spice up the end of your day.


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Jazz 89.5-2 host
Co-host of BusinessWorld
Host, Performance Oklahoma
Local & Regional
9:09 am
Sat June 5, 2010
169 Shut Down in Rogers County
By KWGS News
Talala, OK – A semi overturned early Saturday on a stretch of Highway 169, one mile north of Talala in Rogers County. The Oklahoma Highway Patrol says the truck was carrying hazardous chemcials and the area around the accident has been sealed off until the spill is contained and the wreckage removed. The OHP says that is expected to take most of Saturday morning.
Northbound travelers are being urged to take Highway 20 to U.S. 75, then north of 75 to Bartesville. Take Highway 60 east back to 169.


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2008 Domaine Lécheneaut Chambolle-Musigny 1er Cru
Approximate retail $70. A blend of two vineyards. Aged 18 months in 75% new French oak, otherwise vinified identically to the Chambolle-Musigny. · A clear step up in quality. More aromatic featuring deep red fruits and spice, mild tannins, and some length on the finish. An impressive wine. Reviewed August 23, 2012
Winery: Domaine Lécheneaut From article: Highlights of the Pinot University Seminars at IPNC


text:
Ireland exits Euros with 1.4m
Ireland's final appearance in the Euro 2012 tournament peaked with more than 1.4m viewers.
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At least there's that pretty girl in the last two photos. Probably made the trip worth it :)
Haha! That "pretty girl" was my best friend from the sandbox and on... She was like a sister to me until I went off the deep end by the time I hit my twenties and lost touch with everyone I knew growing up. And yes, getting to see her again was, by far, the highlight of my evening.


text:
Essential Eddie: Van Halen's Greatest Guitar Solos
Is this the Greatest Photograph in Rock History?
5 Unbelievable Facts About Marvin Gaye's "What's Going On"
Henry Rollins Weighs in on Cleveland's Punk Rock Past
5 Must-See Items in the Rock Hall's New Paul Simon Exhibit
What are Paul McCartney's Favorite Ringo Starr Songs?
Rock Hall 2015: Who's Getting Inducted, How to Get Ceremony Tickets and the New Exhibit in Cleveland
Ian McLagan and Small Faces/Faces Bandmates Light Up Inductions Stage with "Stay With Me" in 2012
Bobby Keys' Blistering "Can't You Hear Me Knocking?" Solo Live in Cleveland
Remembering 2012 Rock and Roll Hall of Fame Inductee Ian McLagan
How do you capture the dynamism of live performance on a two-dimensional screen? In celebration of Black History Month, the Rock Hall will present a special film series, "Double Exposure: African American ...
Categories: Black History Month


text:
June 18th, 2009 at 12:46 pm
Which TV Shows Generate The Most Advertising Revenue?
Which broadcast prime-time shows likely made the most advertising money during the 2008-9 season?
[Read-More]June 18th, 2009 at 12:32 pm
DVRs remain a much bigger threat to prime-time TV biz models than Internet viewing
nothing new here for regular readers, really, but USA Today is spinning the season ending DVR data: New DVR data for the
[Read-More]June 18th, 2009 at 12:18 pm
Posting its Best Numbers in Viewers and Adults 18-49 Since March, Jimmy Kimmel Live Delivers its Strongest Summer Performance in 3 Years
via ABC press release: Posting its Best Numbers in Viewers and Adults 18-49 Since March, "Jimmy Kimmel Live" Delivers its Strongest Summer
[Read-More]June 18th, 2009 at 11:10 am
Gunsmoke, Lonesome Dove Top List of Greatest TV Westerns
Of course, this is just the Western Writers of America's collective idea of the greatest, but it's still interesting. You can see
[Read-More]June 18th, 2009 at 10:44 am
CBS's Late Show in closest competitive position to The Tonight Show since December 2005
via CBS press release (you can see the NBC spin on the matter here): CBS's "Late Show with DAVID LETTERMAN" IN CLOSEST
[Read-More]June 18th, 2009 at 10:28 am
Conan takes week two in every key category, bests Letterman by 177% with adults 18-34
NBC spins the results of Conan's second week hosting The Tonight Show
[Read-More]June 18th, 2009 at 9:12 am
Wednesday Ratings: FOX and So You Think You Can Dance wipe out the competition
FOX won the night with So You Think You Can Dance, and ABC again got decent mileage out of Wipeout.
[Read-More]June 18th, 2009 at 12:09 am
Showtime picks up Tracey Ullman's State of the Union for a third season
via Showtime press release: SHOWTIME PICKS UP TRACEY ULLMAN FOR A THIRD SEASON LOS ANGELES, CA – (June 18, 2009) – Seven-time-Emmy®-winner Tracey


text:
Having a chronic illness like ME/CFS can make it hard to avoid problems that come from bad ergonomics. Jody Smith has learned some lessons the hard way ...
Discuss the article on the Forums.
Is CMV IgG antibody supposed to be lifelong positive?
Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by hixxy, May 22, 2012.


text:
The rapid fall in oil prices seems to have taken everyone by surprise. I've noted before that it puts the viability of the Keystone XL project in doubt. But its other effects are worth considering.
Overall, the fall in prices should have a beneficial effect on the U.S. economy. Since gasoline … More >


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This is one of my last projects – maternity wool reglain coat without linning. I made this construction myself.
100% wool
Mar 8, 2013, 07.14 PMby merimej
excellent work… i like it:)
Mar 6, 2013, 08.42 PMby adamante
This is an absolutely fantastic construction you made. I also liked the way you incorporated those dark brown details in your design. Well done :)
Feb 26, 2013, 08.23 AMby ladafl
This is so cool! I like your creativity!
Feb 24, 2013, 04.37 PMby mollytov
Gorgeous! The colour's so classy!
Feb 24, 2013, 02.30 PMby Mary Athey
Fab coat.and.pattern drafting. This.is.gorgeous.on you and congrats on your pregnancy x
Check out Denise's new video and find out why you should sign up now!
Why you should wear clothing made to fit YOU! (In GIF's)
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We have just extended registration to accommodate a few more students


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Posted By: | Antoine (Tony) Lamothe | |
Email: | ||
Subject: | Re: Jean-Baptiste Lamothe (pre- 1837) | |
Post Date: | July 11, 2009 at 07:07:45 | |
Message URL: | http://genforum.genealogy.com/lamothe/messages/383.html | |
Forum: | Lamothe Family Genealogy Forum | |
Forum URL: | http://genforum.genealogy.com/lamothe/ |
Hi Laurene, Unfortunately, I do not have any information regarding Mary/Marie Lamothe, who married John Baptiste Leith abt. 1866 in CT. When I conducted my search, all my family links were found in Ontario and Quebec, Canada. I was able to retrace my Lamothe Family liniage back to the early 1600's in France but no further. I guess I will have to travel to France one day to follow up further. Good luck. Salut. Tony (Antoine) Lamothe Ontario, Canada |


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Imperial by name and imperial by nature, this swanky Chinese at Victoria station's Grosvenor Hotel has been regally decked out according to the principles of feng shui (think Victorian coved ceilings meet ornate calligraphy screens). The kitchen offers a hybrid of Cantonese and eclectic Hong Kong-style cuisine, with seafood showing up strongly in the shape of minced prawn balls, with crispy seaweed, steamed turbot with dried orange peel or baked black cod with pepper and honey sauce. Otherwise, expect a lively run from crispy duck salad to spicy 'water-boiled' beef or deep-fried pork ribs with sweet plum sauce. A big contingent of dim sum satisfies the lunchtime crowd, set menus offer an appetising snapshot of the cuisine, and the wine list features some impressive food-friendly Rieslings. Oriental high teas and Chinese-themed cocktails complete the picture.
The Grand Imperial London is, rather perplexingly, situated within the Grosvenor Hotel at Victoria station and is well hidden in plain sight of the road. I say this because despite passing through Victoria station almost every day, I'd never once noticed its presence, nor had it ever occurred to me to look at what lurked behind the hotel's doors.The decor is designed around the practice of Feng Shui – not something I would have known or recognised had I not read it on the website. To my eye, it's a luxurious room designed to scream both 'Chinese restaurant' and 'classy interior' all in one. A little... More from inher30s »
set off on a mission in search of a Peking duck that would leave me a sobbing mess as I reminisced of my childhood. Overly dramatic you say? Peking duck is serious stuff. My search lead me to Grand Imperial, one of two resident lobby restaurants of The Grosvenor and conveniently located next to the Victoria train and underground station. I'm not one to usually be tempted by the hotel restaurant when I am a guest let alone for a night out but I put my scepticism aside and decided to give it a shot. Of course my decision was swayed heavily by the prospect of a whole Peking duck and champagne for two for only £38... More from wetrykai »
I recently spent time in London which is not something that I do that often, due to a busy weekday schedule and my weekends being taken up with various other commitments.I have never had lobster Cantonese style before, as I usually eat lobster when I visit the Caribbean, due to lobster being very expensive within the UK. In my mind I remembered eating lobster in Jamaica where it was boiled with no additional sauce and the lobster meat was very tender and succulent. With my only experience of eating lobster being in the Caribbean I was surprised that the lobster was cooked in a mild ginger and spring onion... More from Food, glorious food »
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POPSUGAR Celebrity 2009 MTV Video Music Awards Photos of The 2009 MTV VMA Show by Celebrity 9/13/09 0 Shares Print 0 0 0 0 0 Previous Photo 1 of 111 View on One Page ADVERTISEMENT ( more slides) Next Share This Link Copy 1 Photos of The 2009 MTV VMA Show Previous Photo 1 of 111 View on One Page ADVERTISEMENT ( more slides) Next 0 0 0 0 0 Read More 2009 MTV Video Music Awards2007 MTV VMAs Get the scoop with our daily newsletter Enjoy the latest news on the celebs you love. TV A Listers Movies Young Hollywood Sign up with 5 years Enjoyed most of the show last nite. Taylor Swift and Beyonce showed alot of class after Kanye showed none.If it wasnt for Alicia Keys singing at the end would have tuned it off sorry but could not understand that JayZ said, said not sang thats not music.Keep up the good work"Twilight" saga actors and actresses, looking good! Link Love Cobie Smulders is out at Sundance three weeks after giving birth — Us Weekly Reese Witherspoon has one cute mini me — HuffPost Celebrity Idris Elba talks James Bond rumors — Lainey Gossip Justin Bieber hides a new haircut — Dlisted Amanda Peet thought Game of Thrones was an awful idea — ET David Beckham talks Bieber's Calvin Klein ads — JustJared Jessica Alba shows off her workout routine — Hollywood Tuna Diana Ross to have mini Vegas residency — Pink Is the New Blog Emile Hirsch gets into trouble at Sundance — The Superficial Taylor Swift shuts down her hackers —Newser Latest Celebrity
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Leicester police are looking for the owner of a dog believed to have been intentionally abandoned.
Help us find homes for these adorable pets
The female boxer mix was found in Leicester July 28. The dog has since undergone treatment for a prolapsed uterus, according to police.
Police have released a photo of the dog and have asked anyone who heard someone talking about a dog with a similar medical condition to call authorities. Anyone interested in adopting the dog can contact Leicester Animal Control at 508-892-7018.
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April's Art Direction: So there's this cosmic checkerboard, right? And on it we'll have Alexander the Great, a Samurai, and Napoleon just kind of chilling out, each in their own separate square, completely unaware of anything around them. Now we just sit back and wait for the money to roll in.
Published 1995
21 Responses to "The Gamester Wars"
A.R.Yngve Says:
June 8th, 2011 at 10:37 amYou know, 1945? That horrible year of devastation, Holocaust, Hiroshima, Nagasaki, starvation, death and misery?
Yep, those two guys claim responsibility for 1945. I have no idea why they want to carry that burden, but it's their trip.
A.R.Yngve Says:
June 8th, 2011 at 10:38 am"Where history and technology collide…"
But doesn't that always happen? Kinda redundant, eh? -
A.R.Yngve Says:
June 8th, 2011 at 10:39 amI'd rather have all my teeth pulled out with a pair of rusty pliers, than be credited as "co"-ANYTHING with Newt Gingrich.
Phil Says:
June 8th, 2011 at 10:53 amI thought "Newt Gingrich of 1945″ was a Busby Berkely movie, like "Gold Diggers of 1933″.
Where history and technology collide… inside Napoleon's jacket, apparently.
I didn't know that was Alex the Great (top left). I thought it was just some guy with a squashed face and bad hairpiece, carrying a melon.
THX 1138 Says:
June 8th, 2011 at 12:26 pmNo, no, no, they have it all wrong, it should be Paul Lynde in the centre square!
Seamyst Says:
June 8th, 2011 at 12:49 pmI'm guessing that the top line is supposed to read, "Coauthored 1945 with Newt Gingrich" (which, incidentally, is also active voice, as opposed to passive).
Unk Says:
June 8th, 2011 at 3:56 pmHistory and technology colliding? Why didn't anybody else think of that before!
Newt Gingrich of 1945:
fred Says:
June 8th, 2011 at 7:37 pmForstchen's "Lost Regiment" series should have spawned some horrid covers given its premise, but alas sanity ruled.
A.R.Yngve Says:
June 8th, 2011 at 8:32 pmApparently, "Gamester Wars" are like "Celebrity Squares" but played over a period of thousands of years.
A.R.Yngve Says:
June 8th, 2011 at 8:34 pmPhil:
There IS a "Newt Gingrich of 1945″ musical movie! Perhaps you've seen it:
http://www.youtube.com/watch?v=K08akOt2kuo -
Prudynce Says:
June 9th, 2011 at 4:14 amI'm mainly confounded by Newt Gingrich.
Ian Says:
June 9th, 2011 at 5:46 amThe trilogy
Game Wars
Gamest Wars
Gamester WarsEach book contains some "eye of newt"
Smith Says:
June 9th, 2011 at 8:03 amWow, this has 5 separate fonts.
Is that a GSS record?
And shouldn't "coauthor" be hyphenated?
As for the samurai, I am reminded of Lord Dark Helmet in Spaceballs.
Whatever happened to Rick Moranis?
Tom Noir Says:
June 9th, 2011 at 1:52 pmThank god, the complete Gamester Trilogy all in one volume. Do you know how hard it is to find these books individually?!?
A.R.Yngve Says:
June 10th, 2011 at 9:04 amSoon, other authors will also try to use politician "cred" to sell their books:
– "Coauthor with Sarah Palin of NOTES ON THE INSIDE OF HER HAND"
– "Coauthor with Anthony Weiner of SAUCY TWITTERS"
– "Coauthor with Bashar Al-Assad of TORTURE AND EXECUTION MEMO"
– "Coauthor with G.W.Bush of MY BIOGRAPHICY by George W. Bush"
Zycrow Says:
June 10th, 2011 at 4:01 pmSeems like there's a lot more colliding here than just history and technology. My head against a brick wall, for example.
Dalton H. Says:
June 20th, 2011 at 4:12 pmNewt Gingrich?!? The politician?!?
Anti-Sceptic Says:
June 29th, 2011 at 7:54 pmEveryone sing: "Here is the story…of a man named Brady…Who was busy with three boys of his own…They were four men, living all together,
Yet they were all alone. " – ah the good old days when family values meant something…I wonder what kind of family values you'd get with Alexander, a Samurai, and Napoleon? -
Jami Says:
August 5th, 2011 at 5:51 pmAh! I see I'm not the only one who thought of The Brady Bunch when viewing this cover.
Muttley Says:
August 5th, 2011 at 11:04 pmGiven the level of historical accuracy on show here, that's probably supposed to be Genghis Khan in the middle.
Tom Noir Says:
August 8th, 2011 at 9:29 pmGiven the author's connection to the noted Senator, Twitterer and 2012 Presidential Candidate, you'd think giving old Newt a square on the board wouldn't have been out of the question.


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Monaco Government Tourist and Convention Office
7 Upper Grosvenor Street
London W1K 2LX
Tel : +44 (0)207 491 4264
Fax : +44 (0)207 408 2487
A boxing event that is unique in Europe will take place on 30 March 2013
The African promoter Golden Gloves Ltd is joining forces with the Monte-Carlo Casino to announce the "Monte-Carlo Million Dollar Super Four," a boxing event that is unique in Europe.
On the same evening, this event will offer the WBA World Middleweight Championship, the European Junior Middleweight Championship and a unique elimination event featuring four world boxing stars, the "Super 4," with fights between Edwin Rodriguez (22-0, 15 KOs), Zsolt Erdei (33-0, 18 KOs), Denis Grachev (12-1-1, 8 KOs) and Ezequiel Osvaldo Maderna (19-0, 13 KOs).
On 13 July, the two winners of the Super Four will compete for a million-dollar prize. The final of the "Monte-Carlo Million Dollar Super Four" will also celebrate Nelson Mandela's 95th birthday.
The "Monte-Carlo Million Dollar Super Four" will be broadcast internationally, including western European countries, the United States, Russia, Kazakhstan, Ukraine and 50 countries throughout sub-Saharan Africa, as well as the neighbouring islands.
The Monte-Carlo Million Dollar Super Four
30 March 2013
At the Sporting Monte-Carlo
Further information and bookings:
Number of views : 554
Yoga Solstice Festival on the Terraces of Monte-Carlo Casino
83rd Rallye Automobile Monte-Carlo from 19 to 25 January 2015
Discover the Mediterranean with the Mediterraneo Monaco Association
Major Concert in Monaco to Celebrate Accordion Player Richard Galliano's Thirty-Year Career
Restaurants in Monaco are Taking Part in the "Goût de/Good France" Project on 19 March 2015
Grisha Bruskin is Exhibiting His Work for Russian Year in Monaco
7 Upper Grosvenor Street
London W1K 2LX
Tel : +44 (0)207 491 4264
Fax : +44 (0)207 408 2487


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COLUMBUS, OH - JANUARY 25: Patrice Bergeron #37 of the Boston Bruins and Team Toews controls the puck against Kevin Shattenkirk #22 of the St. Louis Blues and Team Foligno in the first period during the 2015 Honda NHL All-Star Game at Nationwide Arena on January 25, 2015 in Columbus, Ohio. (Photo by Gregory Shamus/Getty Images)
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used about something that makes an illness start
Click any word in a definition or example to find the entry for that word
to give someone an infectious illness
if a disease spreads, or if something spreads it, it affects more people as it is passed from one person to another
if something such as an illness or a piece of news is going around, people are giving or telling it to each other
English version of thesaurus of to cause someone to have an illness or feel ill
… a teaching method in which groups of children learn independently using a computer linked to the internet
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NCAAB Basketball - Preview
Xavier Musketeers vs. Duquesne Dukes | |
The Xavier Musketeers and the Duquesne Dukes will both be gunning for a victory on Saturday when they meet at A.J. Palumbo Center. Last time out for Xavier, they were a 73-71 loser as they battled Richmond on the road. They covered in the match as a 3.5-point underdog. Duquesne lost its last outing, a 79-57 result against George Washington on February 6. They failed to cover in that game as a 4-point underdog. Xavier: Team record: 12-9 SU, 11-8 ATS The total has gone UNDER in 7 of last 8 games on the road When playing on Saturday are 8-2 Team record: 7-15 SU, 5-13 ATS Current streak: lost 10 straight games. The total has gone UNDER in 5 of last 5 games when playing Xavier When playing on Saturday are 3-7 Xavier home to Fordham, Wednesday, February 13 Duquesne at Temple, Thursday, February 14 |


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The Delta State University Department of Music presents the Woodwind Chamber Ensembles concert Nov. 10 at 7:30 p.m. in the Bologna Performing Arts Center Recital Hall. The event features the DSU Saxophone Quartet and the
Tag Archives: Department of Music
The internationally acclaimed Jazz Ambassadors of Washington, D.C. continue their long tradition of presenting free public performances with a unique appearance at the Bologna Performing Arts Center on the campus of Delta
The Department of Music at Delta State University is pleased to announce the junior recital of Rory Dale Young II, a double major in music education and music performance. The recital will take place Nov. 6 at 1:40 p.m. in
The time has come again to recognize arts and humanities across Mississippi colleges and universities. The Mississippi Humanities Council celebrates each October by awarding one humanities faculty member at each state
The Delta State University Department of Music presents Dr. Joseph Frye, assistant professor of trombone at the University of Tennessee at Martin, in a faculty recital Oct. 13 at 7:30 p.m. in the Recital Hall of the Bologna


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Winnipeg Free Press - PRINT EDITION
Target to price-match online rivals permanently
NEW YORK -- Target Corp. said Tuesday that its pledge to match prices of select online rivals this past holiday season is now a year-round promise.
The second largest discounter behind Wal-Mart Stores Inc. in the U.S. said it will match prices that customers find on identical products at top online retailers, all the time.
The online list includes Amazon.com as well as the websites of Wal-Mart, Best Buy, Toys "R" Us and Babies "R" Us.
Target's holiday price-match program with online retailers began Nov. 1 and ended Dec. 16. Target is also making permanent its holiday offer of matching prices of items found at its stores with those on its website.
And for the first time it will include products that are out of stock on Target.com .
The moves follow a disappointing holiday shopping season for the Minneapolis-based retailer, hurt by stiffer competition from online rivals and stores such as Wal-Mart that have hammered its low prices.
It's also the latest step from brick-and-mortar stores to combat "showrooming" -- a growing trend for customers to browse their stores to check out products, and then go online to buy the same products for less elsewhere.
Mark Schindele, Target senior vice-president of merchandising operations, noted the discounter monitors prices of 30,000 items, and thousands more online, to make sure it's competitive.
But Target says it had to do more to give shoppers more confidence. "We believe that our prices are competitive year-round," Schindele said. "We also know that our guests shop in many ways."
It wasn't immediately clear if Target will offer the same policy to Canadian consumers when it opens its doors for the first time in Canada in March. The expansion, the first for the retail giant outside of the U.S., will see between 125 to 135 locations spring up at former Zellers stores, including four in Winnipeg.
Target is spending about $10 million per store in upgrades, and at some locations will be tripling the existing square-footage space.
The move by the U.S. discount giant is being called one of the most hotly-anticipated expansions into Canada since Wal-Mart opened its doors north of the border two decades ago. It has other Canadian retailers scrambling to figure out how to compete with another major player in an already-competitive market for consumer dollars.
A spokeswoman said Tuesday it's too soon to tell whether the Canadian subsidiary will adopt the price-matching policy.
In the U.S., many major stores already offer price-matching guarantees for local competitors' brick-and-mortar stores, but it wasn't until this past holiday season the focus was on matching online prices. That can be difficult, since online prices tend to be lower and fluctuate often.
Joel Bines, managing director and co-head of the retail practice at AlixPartners, praised recent moves.
"Retailers have finally gotten the message," he said. "You can't put an impediment between consumers and consumption." But he said that the policies can backfire, noting the move could turn out to be "profit-draining" as more people are encouraged to shop the web to get the lowest price.
-- The Associated Press
Republished from the Winnipeg Free Press print edition January 9, 2013 B8
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Songs of Faith and Devotion | ||||
Studio album by Depeche Mode | ||||
Released | 22 March 1993 | |||
Recorded | February 1992 - January 1993, Madrid, Hamburg, London[1] | |||
Genre | Alternative dance, synthpop | |||
Length | 47:26 | |||
Label | Mute (UK), Sire/Reprise Records (U.S./Canada) | |||
Producer | Depeche Mode, Flood | |||
Depeche Mode chronology | ||||
Singles from Songs of Faith and Devotion | ||||
Professional ratings | |
Review scores | |
Source | Rating |
Allmusic | [2] |
Robert Christgau | [3] |
Entertainment Weekly | (B)[4] |
New York Times | (favorable) [5] |
The Guardian | (favorable)[6] |
Rolling Stone | [9] |
Sputnikmusic | [10] |
Songs of Faith and Devotion is the eighth album by the British electronic music group Depeche Mode, released in 1993 on Mute Records in the UK and Sire/Reprise Records in the U.S. and Canada. The album incorporated more guitar textures than previous releases. Upon its release, Songs of Faith and Devotion reached number one in both the UK and US album charts. To support the album, Depeche Mode embarked on the fourteen-month Devotional Tour. As of 2006, Songs of Faith and Devotion has sold more than 920,000 units in the United States.[11]
Contents |
Songs of Faith and Devotion was recorded over eight months in a rented villa in Madrid during 1992[12] as well as later sessions in Hamburg and London.[1] Recording the album was slowed by Gahan's growing drug and alcohol addiction.[1]
A studio was set up in the basement with two drum kits using different spaces to achieve different sounds. The drum kits could then be processed through synthesisers such as the large Roland System 700 the band installed in the studio.[12] The band wanted to record something quite different from previous albums. They wanted to change as many things about their approach to making music as they possibly could.[12] The band members had become aware of getting caught in easy routines leading to boredom.
One new approach to recording was performance. On previous recordings the band had relied more on sequencing than playing.[12] The performance would then later be sequenced and processed in the studio. The band members did not feel capable of going into a room and playing together, they felt that applying technology made their sound more spontaneous and human. They wanted the sound of Songs of Faith and Devotion looser and less programmed.[12]
Tracks like "I Feel You," which was not originally the lead-off track on the album until Alan Wilder fought for it to be that way,[1] included real performed drums which were then sampled and sequenced to form drum loops, using Cubase, in a different structure from how they were originally performed; keeping all the dynamics of a human performance.[12] Some of the embellishments like reversed cymbals were added later in the recording process by Alan Wilder who was nearly always the one to suggest such experimentation.[12]
Further reversing techniques were used throughout the recordings such as the backwards piano recorded as part of the outro to the track "Mercy In You". The introduction to the track "Judas" has uillean pipes recorded normally with reversed reverberation mixed into the sound.[12]
"Walking In My Shoes" included a processed piano part during the introduction. The piano was processed through a guitar processor to add distortion, making it sound more edgy. A harpsichord sample was then played and recorded over the top making a different layered sound.[12]
The recording of the track "Condemnation" used some interesting techniques including all four band members recording one thing each in the same space - Andrew Fletcher bashing a flight case with a pole, producer Flood and Dave Gahan clapping, Alan Wilder playing a drum and Martin Gore playing an organ. The sound produced was very embryonic but gave the band a direction as to how the track should sound.[12]
The album has a lot of recorded guitar with the intention of creating the power of a rock guitar, without the playing technique. Guitar parts were processed through devices such as Leslie tone cabinets, originally designed for use with an organ.[12]
In 2006, Songs of Faith and Devotion was re-released with a bonus DVD. It was released as a part of the second wave of re-issues. (Along with A Broken Frame and Some Great Reward) The first CD was remastered and was released on a CD/SACD hybrid except for in the US where the remastered first disc was pressed to standard CD. The bonus DVD includes a 5.1 surround mix of the original album, the B-Side "My Joy" and the Jazz Mix of "Death's Door" (basically an extended mix of the original version) plus several other remixes.
Also included was a 36 minute documentary on Songs of Faith and Devotion called Depeche Mode 91-94 (We Were Going To Live Together, Record Together And It Was Going To Be Wonderful) named after a quote from Alan Wilder on the potential of living in their Madrid-area recording studio. It features interviews with Depeche Mode (including Wilder, who would leave the band in 1995) and other important DM figures like Daniel Miller, Anton Corbijn and Daryl Bamonte. There is also footage from the movie Devotional and the music videos. The documentary mainly focuses on the extreme difficulty of recording the album, and the even more frustrating 14-month tour that followed.
It was released on 2 October 2006 in the UK and 3 October 2006 in the US.
The remastered album was released on "deluxe" vinyl 2 March 2007 in Germany and 5 March 2007 internationally.
All songs written and composed by Martin Gore.
No. | Title | Length | |
1. | "I Feel You" | 4:35 | |
2. | "Walking in My Shoes" | 5:35 | |
3. | "Condemnation" | 3:20 | |
4. | "Mercy in You" | 4:17 | |
5. | "Judas" | 5:14 | |
6. | "In Your Room" | 6:26 | |
7. | "Get Right with Me" | 3:52 | |
8. | "Rush" | 4:37 | |
9. | "One Caress" | 3:32 | |
10. | "Higher Love" | 5:56 |
2006 re-release bonus tracks | ||||||||||
No. | Title | Length | ||||||||
11. | "My Joy" | 3:57 | ||||||||
12. | "Condemnation (Paris Mix)" | 3:21 | ||||||||
13. | "Death's Door (Jazz Mix)" | 6:38 | ||||||||
14. | "In Your Room (Zephyr Mix)" | 4:50 | ||||||||
15. | "I Feel You (Life's Too Short Mix)" | 8:35 | ||||||||
16. | "Walking In My Shoes (Grungy Gonads Mix)" | 6:24 | ||||||||
17. | "My Joy (Slowslide Mix)" | 5:11 | ||||||||
18. | "In Your Room (Apex Mix)" | 6:43 |
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Olympic Sports - SailingSailing first appeared in the Olympics in 1900 in Paris, but took a break in 1904 after which it has appeared on the menu for every Olympic Games. The sport was called Yachting throughout the twentieth century, and has only been given the title Sailing since the 2000 Olympic Games in Sydney. Women have always been able to take part in the sport, with separate womens events making their debut at the Seoul Olympic Games in 1988. Sailing events in the earlier twentieth century were dominated by big boats, often with several sailors. There was a gradual move - as sailing technology improved - towards smaller boats, including one-person craft. The London Olympics of 1908 saw sailing events at Ryde (Isle of Wight) and at Hunters Quay (on the River Clyde). Great Britain gained a host of medals the only other countries to gain medals being Belgium, Sweden and France - though this may largely have been due to the fact that at the time it was not seen as practical to bring overseas boats to the Games. In contrast the London 1948 Olympics boasted medal winners from nine countries including Cuba, Portugal and the USA. Great Britains only sailing achievement at these games was Gold in the Swallow class won by Stewart Morris and David Bond. Great Britain is surrounded by water; her inhabitants are used to inclement weather; thus it is not surprising that her sailors have done well in Olympic medal tables. Radio 4s The Shipping Forecast - updating ships travelling British seas four times a day on weather and sea conditions is a national institution. English sailing success is not just confined to Olympic competition for instance the inspirational Ellen MacArthur came second in the Vendee Globe round the world sailing race in 2001 when she was just 24 years old. Her early focus and steely determination to be a success at her sport seems similar to the drive of Shirley Robertson OBE. Robertson won Olympic sailing Golds at Sydney in 2000 and Athens in 2004, a unique achievement as no British woman had previously achieved Gold medals at consecutive Olympic Games. London 2012 Olympic sailing events take place at Weymouth and Portland, with six mens and four womens events, divided in to classes depended on type and size of boat. Ben Ainslie, three times Olympic Gold medal winner, heads the British team. Ainslie was one of a crop of sailing medal winners at the 2008 Beijing Olympics who included: - Ben Ainsley (Finn heavyweight dinghy) - Paul Goodison (Laser one person dinghy) - Iain Percy and Andrew Simpson (Star keelboat) - Sarah Ayton, Sarah Webb and Pippa Wilson (Yngling keelboat). London 2012, in waters that the Great Britain sailing team are likely to know better than their competitors, provides an opportunity for British sailors, male and female, to add to an already impressive collection of Olympic medals. If you are interested in finding out more about Olympic sailing successes you may enjoy Sailing Gold: Great Moments in Olympic Sailing History. If you are interested in learning more about the unique achievements of a woman who has mastered long distance sailing try Ellen MacArthurs highly readable autobiography, Taking On The World. I have provided links to both books below.
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Shot in the town of Koprivshtitsa, Bulgaria. Now the town was tranquil. Yet it was one of the centers of the April Uprising in 1876. Old houses along the street were remained in this town.
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I am collaborating on this project with a colleague, and we're marking this stuff up back and forth and making changes. In the olden days, what we used to do was print it out, send it to the other person, she'd mark it up, she'd send it back, I'd make the corrections. That takes a lot of time, and it kills trees. So a far more efficient way to do this is to use the tools in Adobe Acrobat. And two of the most commonly used tools are up here in the toolbar by default. So first off, I want to tell her that I want to use a bigger logo here. So I'm going to put on a sticky note.
When I click on that little icon and then I click on the page, it creates a sticky note. So you might think of this icon as sort of the anchor for the sticky note, but Acrobat puts the note out to the side. It's trying to not cover up content. But that's okay. I'm going to move it into position just because I want it to be apparent that it's related to that little icon. I can change some things about this. If I click this little tiny triangle, I get some options. When I go to Properties, I can choose the icon that represents the note. So there's a number of very festive icons that you could use.
I am sort of old-fashioned. I tend to stick with the old comment. And if I wanted to change the color of it, I can do that. In fact, what I like to do is make sure that each person that's marking up the file uses a unique color, and that way it's easy to recognize immediately who is making remarks. Then when I click OK, there we go. This little icon at the top-right lets me close a little note. Here is something else I want to mark up. This line spacing seems to be off. So to indicate that, I am going to get my highlighter--and it's just like a real-world highlighter, you just drag across the text.
It gets highlighted, but it looks like there's no note. There is. If I right-click on that highlight, then I have the option to open the pop-up notes. So you can add a note pretty much to any annotation that you place on the file. So I am going to drag this one over again and just tell her "Line spacing should be fixed." Again, if I wanted to check the properties, I can change the color of that highlighting if I want. I think I'll probably change it to my trademark green, click OK, and that makes it sort of obvious and then I can close the note.
So in the next few videos I am going to show you other markup tools, and then I am going to show you an efficient way to send just the markups. For now if I wanted to send this marked-up PDF back to her, that's sufficient information for her. But as you will see later on, rather than sending the whole PDF and the markups, you can sort of peel up the markups and send them all by themselves. So we'll do that in a subsequent video.
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Telephone: +39-02-57489830; Fax: +39-02-94375990
Cancer Stem Cells
Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion†‡§
Article first published online: 9 APR 2012
DOI: 10.1002/stem.1056
Copyright © 2012 AlphaMed Press
Additional Information
How to Cite
Ortensi, B., Osti, D., Pellegatta, S., Pisati, F., Brescia, P., Fornasari, L., Levi, D., Gaetani, P., Colombo, P., Ferri, A., Nicolis, S., Finocchiaro, G. and Pelicci, G. (2012), Rai is a New Regulator of Neural Progenitor Migration and Glioblastoma Invasion. STEM CELLS, 30: 817–832. doi: 10.1002/stem.1056
- †
Author contributions: B.O. and D.O.: conception and design, data collection and/or assembly, data analysis and interpretation, manuscript writing; S.P. and G.F.: data analysis and interpretation; F.P. and P.B.: data collection and/or assembly and data analysis and interpretation; L.F.: statistical analysis; D.L. and P.G.: GBM provision; P.C. and A.F.: data collection; S.N.: data interpretation; G.P.: conception and design, data analysis and interpretation, manuscript writing, and final approval of manuscript. B.O. and D.O. contributed equally to this article.
- ‡
Disclosure of potential conflicts of interest is found at the end of this article.
- §
First published online in STEM CELLSEXPRESS February 6, 2012.
Publication History
- Issue published online: 9 APR 2012
- Article first published online: 9 APR 2012
- Accepted manuscript online: 6 FEB 2012 12:19PM EST
- Manuscript Accepted: 20 JAN 2012
- Manuscript Received: 14 OCT 2011
Funded by
- FIEO fellowship
- Veronesi Foundation
- Regione Lombardia ASTIL
- Abstract
- Article
- References
- Supporting Information
- Cited By
Additional Supporting Information may be found in the online version of this article.
Filename | Format | Size | Description |
STEM_1056_sm_SuppFig1.pdf | 207K | Figure S1. Immunohistochemistry validation of the anti-Rai mouse monoclonal antibody. Rai expression in WT and Rai−/− adult mouse brains. (A-B) Representative H&E sections of WT and Rai−/−. (C-F) Immunostaining with the mouse monoclonal antibody raised against Rai: strong reactivity is observed in the cortical neurons of WT mice (C, E), while no Rai expression is detected in Rai−/− mice (D, F). | |
STEM_1056_sm_SuppFig2.tif | 297K | Figure S2. Cells grown under different experimental conditions express similar levels of Rai. Western blotting: Rai expression in hGBM NS derived from two patients grown under different experimental conditions: standard growing conditions (G) and after EGF and FGF withdrawal (S). Note that when cells are grown in the absence of growth factors the EGF Receptor (EGFR) is not tyrosine-phosphorylated (upper blot). The blot was cut and reprobed with an anti-EGFR antibody (middle bot) and anti-Rai antibody (lower blot). _-Vinculin was used as protein loading control. | |
STEM_1056_sm_SuppFig3.pdf | 517K | Figure S3. Rai silencing in GBM neurospheres results in improved mice survival. (A) Western Blotting: Rai protein levels in NT shRNA and Rai shRNA neurospheres derived from several patients. (B) Kaplan-Meyer survival curves: increased mice survival after injection of Rai-silenced cells into the nucleus caudatus of immunodeficient mice; **p = 0.0081 for 105 injected hGBM#7 cells, n = 6 mice for naϊve cells, n = 6 mice for NT shRNA cells, n = 15 mice for Rai shRNA cells; *p = 0.0246 for 105 hGBM#9 cells, n = 3 mice for each condition; p < 0.0001 for 105 hGBM#10 cells, n = 9 mice for each condition; *p = 0.0455 for 105 hGBM#18 cells, n = 3 mice for each condition; *p = 0.0224 for 105 hGBM#20 cells, n = 3 mice for each condition; **p = 0.0027 for 105 hGBM#22 cells, n = 5 mice for each condition. (C) H&E staining of xenograft tumors derived from NT shRNA and Rai shRNA hGBM#7 cells. Homolateral hemispheres, tumor centre and contralateral hemispheres are shown. Note the invasive tumor cells localized away from the main tumor mass, infiltrating the homolateral and the contralateral periphery in control brains, and the smoother borders of Rai-silenced tumors. | |
STEM_1056_sm_SuppFig4.pdf | 834K | Figure S4. Rai silenced tumors show reduced infiltrative growth. (A - P) Immunostaining for anti-human Nuclei on xenograft tumors derived from NT shRNA and Rai shRNA hGBM#7 (A - F) and hGBM#10 (G - P) cells. Low and high magnifications are provided. (Q) Maximal tumor areas measured per section (n = 3 mice per group), *p <0.05. | |
STEM_1056_sm_SuppFig5.pdf | 318K | Figure S5. Rai silencing does not affect proliferation in vivo. (A) Percentage of Ki67 positive cells in NT and Rai-silenced xenograft tumors (n = 3 sections per mouse). (B) Immunostaining for Ki67 on xenograft tumors derived from NT shRNA and Rai shRNA hGBM#7, hGBM#8, hGBM#18 and hGBM#22 cells. | |
STEM_1056_sm_SuppFig6.pdf | 349K | Figure S6. Rai silencing in GBM neurospheres results in reduced GBM invasiveness. (A) Immunostaining for Dcx and GFP on xenograft tumors derived from orthotopic injection of NT shRNA and Rai shRNA hGBM#7, hGBM#18 and hGBM#20 cells. (B) Immunofluorescence staining for Dcx (green) and human mitochondria (red) on tumors derived from orthotopic injection of NT shRNA and Rai shRNA hGBM#10 NS and on tumors derived from orthotopic injection of hGBM#7 NS isolated from serially transplanted xenografts. Nuclei were counterstained with DAPI (blue). Human mitochondria immunoreactivity identifies human tumor cells. | |
STEM_1056_sm_SuppFig7.pdf | 637K | Figure S7. Rai is distributed at the periphery of the tumor. Immunohistochemical staining for Rai on xenograft tumors derived from NT shRNA and Rai shRNA hGBM#7, hGBM#9, hGBM#10, hGBM#18, hGBM#20, hGBM#22 cells confirms its expression in control tumors, both in the tumor centre and at the edge (arrowheads), and its absence in silenced tumors, with the exception of rare cells at the infiltrative margin (arrowheads). | |
STEM_1056_sm_SuppFig8.pdf | 423K | Figure S8. The reduced GBM invasiveness associated with Rai silencing is a dosagedependent effect. (A) Western Blotting: Rai protein levels in NT shRNA and Rai shRNA neurospheres derived from GBM#11 patient. (B) Kaplan-Meyer survival curve: partial suppression of Rai expression by siRNA does not affect mice survival, compared to control tumors. n = 3 mice for each condition. (C) Tumors grown by orthotopic transplantation of partially Rai-silenced stem/progenitor cells show similar histology and express Rai at similar degree compared to control tumors. | |
STEM_1056_sm_SuppFig9.pdf | 582K | Figure S9. Rai silencing in GBM neurospheres improves mice survival in serially transplanted mice. (A) Western blotting: Rai expression levels in hGBM#7 and hGBM#8 neurospheres isolated from primary xenografts. (B - C) Kaplan-Meyer survival curves: reduced Rai expression in hGBM#7 and hGBM#8 neurospheres isolated from primary xenografts increases mice survival after orthotopic injection. (B) **p = 0.0002 for 105 hGBM#7 cells, n = 6 mice for naϊve cells, n = 6 mice for NT shRNA cells n = 12 mice for Rai shRNA cells. (C) p = 0.0224 for 105 hGBM#8 cells, n = 3 mice for each condition. (D) Secondary xenografts show histological features of the correspondent primary xenotransplanted lesions, and express the Rai protein at similar levels as assessed by H&E and Rai staining. | |
STEM_1056_sm_SuppFig10.pdf | 342K | Figure S10. Rai is expressed in the subventricular zone and does not affect either proliferation or apoptosis. (A) X-gal staining on coronal section of mouse Rai-LacZ knock-in brain: Rai_-gal is expressed in the SVZ. Higher magnification of the boxed areas shows Rai positivity (arrowheads) at the beginning of the RMS (box 1) and in some periventricular cells (boxes 2 and 3). (B - C) Cell count of Ki67 positive cells on coronal sections of WT and Rai−/− mice show the same amount of steady-state proliferating cells in the SVZ. (B) Representative image of immunofluorescence staining for Ki67 (green); nuclei were counterstained with DAPI (blue). (C) Quantification of the number of Ki67 positive cells in the SVZ of WT and Rai−/− mice; no differences were observed, as assessed by t-test: p = 0.8, n = 6, mean±SD. (D) Immunofluorescence staining for cleaved caspase-3 (red) on SVZ coronal sections of WT, Rai−/− and irradiated WT mice, which were used as positive control, since no positive cells were detected in WT and Rai−/− brains. Nuclei were counterstained with DAPI (blue). Higher magnification of the boxed areas shows cleaved caspase-3 positive cells at the beginning of the RMS in the irradiated control mice only. | |
STEM_1056_sm_SuppFig11.tif | 967K | Figure S11. Rai regulates cell migration and infiltration through novel multiple pathways. (A) Western blotting: phosphorylation status of Akt in control and Rai-silenced GBM neurospheres. (B) Western blotting: phosphorylation status of Akt in WT and Rai−/− normal neurospheres. (C) No association was observed between Rai mRNA expression level and pAKT as measured by IHC. The proportion of elevated pAKT expression is lower than expected in the proneural compared to the other subtypes (÷2 =16.4 *p<0.01 DF=4 after Yates' correction). One way ANOVA (F=1.41; p=0.25; DF=2;61). Multiple t-test with Bonferroni's correction: not significant. No association is observed between CGH ratios for the PTEN locus and Rai mRNA expression levels (F=1.39; p=0.29 with GLM-ANOVA), independently of the tumor subtypes (F=0.63; p=0.54 with GLM-ANOVA). No association is observed between EGFR gain or amplification and Rai mRNA expression levels (F=1.78; p=0.14 with GLM-ANOVA), independently of the tumor subtypes (F=0.06; p=0.94 with GLM-ANOVA). (D) Western blotting: phosphorylation status of _-catenin in control and Rai-silenced GBM neurospheres. (E) Western blotting: reactivation of the NF_B pathway in Rai-silenced GBM neurospheres transduced with a lentiviral vector carrying p65 cDNA and then stimulated with TNF-_ for the indicated time points. (F) Western blotting: Rai overexpression induces NF_B p65 subunit accumulation in the nucleus. T98G cells were transduced either with a retroviral vector carrying RAI cDNA or with an empty vector as a negative control, and then stimulated with TNF-_ for the indicated time points. (G) NF_B promoter driven luciferase reporter assay: Rai overexpression in 293T cells induces a significant increase in NF_B dependent gene transcription. Luciferase activity was measured 48h after transfection and normalized to the co-transfected Renilla luciferase construct; mean±SD, **p < 0.01. | |
STEM_1056_sm_SuppFig12.tif | 698K | Figure S12. Rai expression is higher in the Proneural subtype GBM. (A – B) Rai expression is higher in proneural subtype tumors compared to mesenchymal and proliferative subtypes. (A) Analysis of Rai expression in 75 GBMs derived from Phillips' work classified as proneural (PN), proliferative (Prolif) and mesenchymal (Mes). (B) Analysis of Rai expression in 200 GBM samples derived from Verhaak's work classified as proneural (PN), classical (CL), neural (NL) and mesenchymal (Mes). Data from samples assayed on three gene expression platforms (Affymetrix HuEx array-Broad202, Affymetrix U133A array-LBL202, and Agilent 244K array-UNC202) were analyzed. Y axes represent average expression values with a 95% confidence limit. The difference between groups was assessed by one-way ANOVA. To account for multiple comparisons, multiple t-test with Bonferroni's correction was applied. (C) Rai expression in gliomas from Phillips' work significantly correlates with Notch pathway activation: Rai expression is higher in those tumors which show a higher activation of Notch evaluated by IHC; proneural tumors are more frequent among high-Notch tumors (÷2=11.1, *p<0.05, DF=4 after Yates' correction). Statistical analysis: one way ANOVA (F=3.38; *p<0.05; DF=2;40); multiple t-test with Bonferroni's correction, Low vs High: Avg diff value = 0.85*; p<0.05, Medium vs High Avg diff value = 1.15**; p<0.01, Low vs Medium Avg diff value = 0.3 n.s.; p=0,87. | |
STEM_1056_sm_SuppTab1.pdf | 14K | Supplementary Table 1. | |
STEM_1056_sm_SuppTab2.pdf | 13K | Supplementary Table 2. | |
STEM_1056_sm_SuppTab3.pdf | 14K | Supplementary Table 3. | |
STEM_1056_sm_SuppTab4.pdf | 39K | Supplementary Table 4. |
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Staff Reporter
THIRUVANANTHAPURAM: Principal Sessions judge K. Ramakrishnan on Thursday sentenced Rajesh, a resident of Lalitha Bhavan, Kadinamkulam, in the district to 10 years rigorous imprisonment and a fine of Rs.1 lakh for carrying 2.5 kg of hashish two years ago.
The court also sentenced the second accused, Chandran, a resident of Thunduvila Veedu, Paravoor, to 10 years rigorous imprisonment for attempting to carry hashish and another 10 years rigorous imprisonment for hatching the plot.
The judge fined Chandran Rs.1 lakh each for the two offences.
Rajesh, the first accused in the case, was held with 2.5 kg of hashish from Sreekariyam on October 20, 2006, by a team led by the Excise Circle Inspector B. Suresh Kumar.


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Kenny Chesney Helps Boston Bombing Victims
Kenny Chesney has established the 'Spread the Love' Fund to help the victims of the Boston Marathon bombings.
Stella Tremblay, New Hampshire Legislator, Says U.S. Government Planned Boston Bombing [Video]
Stella Tremblay, a New Hampshire Legislator is getting conspiracy theorists whipped up in a frenzy by stating she thinks the U. S. Government planned the Boston Marathon bombings.
Dzhokhar Tsarnaev Will Not Be Tried As Enemy Combatant, Charged With Conspiring To Use Weapon Of Mass Destruction
"We will prosecute this terrorist through our civilian system of justice," Carney said. "Under U.S. law, United States citizens cannot be tried in military commissions."
CNN Reporter Susan Candiotti Makes On-Air Blunder During Live Coverage Of Boston Bombings [Video]
Last week's horrible situation in Boston had news outlets all over the country scrambling to cover the events and bring us accurate information. CNN sent their seasoned correspondent Susan Candiotti to cover the bombings in Boston, and it was during this coverage she made a lil blunder. Susan, what does it seem like happened in Boston?
Bostonians Celebrate In The Streets In Moments After Bombing Suspect Arrested [VIDEO]
Students at Northeastern University crowded into the streets, clapping and cheering at passing police officers, waving American flags and singing the country's National Anthem.
Manhunt Over: Boston Marathon Bombing Suspect Captured
A massive manhunt that spanned several Boston communities has come to an end with Boston police announcing that 19-year-old Dzokhar Tsarnaev, the second suspect in the Boston Marathon bombing, has been captured.
Second Suspect In Boston Marathon Bombing Arrested
19-year-old Dzhokhar A. Tsarnaev has been taken into custody.
Boston Marathon Bombers: One Suspect Captured; One Dead [UPDATED]
The second suspect in the Boston Marathon bombing has been captured. Dzokhar Tsarnaev was taken into police custody Friday night -- five days after the bombing that left three dead and left more than 100 injured, police said. The 19-year-old was apprehended after a manhunt that began Thursday night with the fatal shooting of an MIT officer and extended into the evening hours on Friday.
Bombing Suspects' Uncle: 'We're Ashamed' And 'They Are Losers' [Video]
Today, we got to see the Uncle of the Boston Marathon suspects Ruslan Tsarni live on t.v. denounce the actions of his 2 nephews, their family, and called them "Losers". Check out the live interview below


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Additional Information
Future promotes James Ranson to head London sales
Special interest publisher Future has promoted James Ranson to the role of sales director at its London office.
T3: Future technology title
As well as managing and directing the London advertising sales team, Ranson will work with Clare Coleman-Straw, Future's Bath-based sales director, and Nick King, digital commercial director, to maximise commercial potential.
The appointment follows the departure of advertising director Malcolm Stoodley to CBS Outdoor in September. Ranson has been promoted from head of sales for Future's technology group, which includes gadget magazine T3.
He will report to Mark Wood, Future's chief executive officer, who said: "Our business is changing at speed and our digital audience is growing rapidly. We need to keep rethinking and reshaping our approach to ad sales and James has already shown he is the person to do that. He heads a strong group of managers and a dynamic ad sales team. He has the ideas, drive and determination to make them the most formidable sales force in London."
Ranson joined Future in October 2009 as advertising sales director for T3 after working across tech and auto brands at Haymarket and Incisive Media.
Follow @DanFareyJonesThis article was first published on mediaweek.co.uk
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Tuition Remission Benefits for Your Dependent Children
Once you have satisfied the service requirements, each of your eligible unmarried dependent children may take up to eight semesters through the Tuition Remission Program, as long as they apply, are admitted to, and are enrolled in undergraduate degree programs at Boston University or as seniors at Boston University Academy. The amount of Tuition Remission benefits granted for their courses depends upon your length of eligible service with the University. Tuition Remission is not available for any graduate courses taken by dependent children.
If your employment ends before the first day of classes, your dependent will be required to pay full tuition for the courses taken that semester. If your employment ends before the last day of classes, your dependent's benefits will continue until the end of the semester.
In the event your unmarried dependent children have received eight semesters of Tuition Remission benefits and need an additional semester to complete their undergraduate studies, it may be possible to repay the University for one semester of Tuition Remission benefits that were previously received in exchange for Tuition Remission benefits for a prospective semester. Please contact Human Resources for additional information regarding this provision.


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My mom and I are both on Weight Watchers and we ate lunch together. 1 cup of your chili with 1 cup of whole-wheat noodles. We loved it! Only 5 pts too! Thank you for healthy, tasty, wonderful chili. We both appreciated it.
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Dr. Roderick A. Moore, MD
Podiatric Medicine, Dr Rodrick A Moore
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Spring Time Salad Dressing ~ Strawberry Vinaigrette
Are you one of those women who love to drench your salad in ranch dressing? I mean, drench your salad to the point where you can no longer see any green on the plate??? If yes, then today's post is dedicated to you.
Salads are the easiest thing to make to get more fresh greens into your body. I hear many women say that they get bored with the same salads all the time. However, if you know the basics of a good salad dressing, there is no end to the number of flavorful dressings you can create. Store bought salad dressings are filled with unhealthy fats, preservatives, sugar, and a number of other things that no person who is interested in living a healthy lifestyle.
When I make my salad dressings, I usually drench my greens in my homemade dressings (depending on what it is made of, of course…). This sweet and savory strawberry vinaigrette is one of those dressings you can coat your greens with. I paired it with some simple spicy arugula and a few slices of sweet yellow peppers. The dressing is rather strong, so it should be eaten with something that will withstand the flavor like arugula or even kale. Spring Mix may just wilt away and be too light for this dressing. Enjoy!
10 fresh strawberries, crushed
1/4 cup rice vinegar
1/4 cup extra virgin olive oil
1 clove garlic, minced
1 teaspoon honey
salt and pepper to taste
Put all these ingredients into a closed container and shake well. The measurements are approximate and can be adjusted to suit your tastes.
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My name is Halona Black and my life begins in the kitchen! What does that mean, you ask? It means I take responsibility for my own life by eating foods that nourish and heal. Want to learn how to do the same? Contact me at chef at GarlicAndLemonsLLC dot com.Categories
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I would certainly hope so. He's playing matches and scoring goals. What more could a striker want?


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Would like to locate information on the above family. Margaret Duff and John McCroskey were in Pendleton Dst. SC in the early 1800s..may have travelled to S.W. Kentucky with Agnes Carson Duff, widow of James DUFF, and sons, Samuel C., James Jr., dau. Nancy, and others. Margaret Duff was the daughter of James and Agnes Carson Duff- mentioned in James Will as well as her husband John McCroskey. Appreciate any info on these families. They may have moved into N.E. Texas in about 1820-30 time period. Will share what I have so far. Thanks. B. Smith Notify Administrator about this message?
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I believe Robert VanSandt may be my great great grandfather. The information I have on him though only gives the name of his wife as being a Sarah Kween (who I can't find any information on). My great grandfather was their son Thomas Lonzo VanSandt born 29 Jul 1887 in Springdale, Arkansas and died 26 Jun 1966. My mother knows there is supposed to be Cherokee on that side of the family which leads me to believe my Robert VanSandt is the same as yours. Notify Administrator about this message?
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Inter leapfrogs Hellas Verona with win
Inter Milan got back to winning ways with a 4-2 victory over promoted Hellas Verona in Serie A on Saturday for a first win in four matches.
Verona was in fourth, a point ahead of Inter, heading into the match but Walter Mazzarri's team stormed into an early two-goal lead after poor defending by visiting Verona.
A corner came out to an unmarked Jonathan, whose volley was deflected into the back of the net in the 10th minute, and Rodrigo Palacio chested in a second two minutes later after Fredy Guarin's effort was cleared off the line.
Verona grabbed one back shortly after half an hour when Luca Toni knocked the ball down to Martinho, who forced his way into the area and drove a fine strike into the bottom right corner.
However, Inter restored its two-goal cushion six minutes later. Yuto Nagatomo's shot crashed off the far post and Palacio stabbed the rebound goalwards for Cambiasso to tap in.
Rolando extended Inter's lead 12 minutes after the break, bundling the ball home from practically on the line for his first goal for the club since joining on loan from Porto.
Romula fired Verona back into the game in the 71st minute and Toni thought he reduced the deficit further five minutes later but his effort was harshly ruled out for a perceived foul on Inter defender Andrea Ranocchia.
Inter forward Ishak Belfodil and Verona defender Vangelis Moras were shown red cards after the final whistle for an off-the-ball scuffle.
Inter moved provisionally six points behind leader Roma, which has won its opening eight matches and plays Udinese on Sunday.
Earlier, Sampdoria picked up its second victory of the season with a 1-0 win over 10-man Atalanta.
Atalanta, which had won three matches in a row, should have taken the lead on the stroke of halftime but Cristian Raimondi headed off the crossbar.
Shkodran Mustafi headed Sampdoria in front 10 minutes after the break. Atalanta midfielder Luca Cigarini tried to hit the ball away from goal but couldn't prevent it from going in. The referee initially showed him a red card and awarded a penalty but then opted to allow the goal and keep Cigarini on the pitch.
Atalanta was reduced to 10 men seven minutes later when substitute Constantin Nica was sent off in only his second Serie A appearance after bringing down Eder.
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