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Latest Becker's muscular dystrophy Stories
The saying "Knowing is half the battle" is never more true than when discussing early treatment of disease. Muscular dystrophy is one such disease where patients can benefit from early treatment.
- Funding supports continued focus on rare disorders - SOUTH PLAINFIELD, N.J., June 15 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC) today announced the receipt of two government grants to support clinical development programs in rare disorders. The U.S.
Researchers at the University of Minnesota Medical School have discovered a new therapy that shows potential to treat people with Duchenne muscular dystrophy, a fatal disease and the most common form of muscular dystrophy in children.
Boys show signs of Duchenne Muscular Dystrophy (DMD) for 2 ½ years before they obtain a diagnosis and disease-specific treatment, about the same length of delay children have endured for the past 20 years despite advances in genetic testing and treatment.
Researchers at University of Florida -- Gainesville, University of California -- Los Angeles to Receive $250,000 For Duchenne Muscular Dystrophy Research MIDDLETOWN, Ohio, May 5 /PRNewswire-USNewswire/ -- Patricia A.
Former New York Giants Jim Burt and Bart Oates Help Raise Money and Awareness for Duchenne Muscular Dystrophy FORT LEE, N.J., April 30 /PRNewswire-USNewswire/ -- Pat Furlong, Founding President and CEO of Parent Project Muscular Dystrophy (PPMD) announced today that former New York Giant stars Jim Burt and Bart Oates will join hundreds of guests for the 1st Annual Pour for a Cure, supporting PPMD, at the Hyatt Regency in New Brunswick, New Jersey on May 8, 2009.
Using a novel genetic technology that covers up genetic errors, researchers funded in part by the National Institutes of Health have developed a successful treatment for dogs with the canine version of Duchenne muscular dystrophy, a paralyzing, and ultimately fatal, muscle disease.
Muscular dystrophy, which affects approximately 250,000 people in the United States, occurs when damaged muscle tissue is replaced with fibrous, bony or fatty tissue and loses function.
- Monstrous in size or character; huge; prodigious; monstrously perverse, savage, cruel, etc.


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Recent Comments
- 1 month ago All the best!
- 2 months ago Internet access is human rights!
- 2 months ago WP will never close the gap to Android, coz WP don't have apps called "Task Killer", "Memory clean" :P
- 2 months ago Samsung is a lousy looser, they will eventually eat its own shit!
- 4 months ago The few dictatorship government
- 4 months ago Agreed!
- 4 months ago The world is better without China.
- 5 months ago Would appreciate if HTC can have the size of M7 not M8 for WP. :)
- 6 months ago The name should called "小三" hahahaha
- 6 months ago The world should ditch the China Market, they are another dictatorship government
- 6 months ago I stick my life to it, if M$ ditch WP, I'll never use Android either, buy an apple is better to support the copycat
- 6 months ago That's the most stupid thing that M$ can do.
- 7 months ago Agreed, at lease for the next century
- 7 months ago Agreed
- 7 months ago Sure it's nit a good news, but it is a GREAT news !!!
Recent Forum Posts
- Member for
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subset: commoncrawl


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Email Alerts
FAST, Trading Standards piracy campaign heads for South East
The Federation Against Software Theft (FAST)and Trading Standards areto bringtheir anti-software piracycampaignto London and the South East, writes Linda Endersby The 'Software - Stay Legal' programme for the region mirrors initiatives in northern En... News | 05 Apr 2012
Resellers credited with input into IBM big data product launch
In conjunction with business partners IBM has developed software specifically designed to tap into the growing demand for big data solutions. Big Blue's DB2 and InfoSphere Warehouse applications have been four years in the making and involved input ... News | 03 Apr 2012
Red Hat breaks through $1bn revenue barrier
Open source specialist Red Hat has broken through the $1bn revenue mark with the channel a key factor in the firm's success. The results for the full fiscal year ended 29 February saw the firm reach $1.13bn, a 25% year-on-year increase, and net inco... News | 29 Mar 2012
Channel braced for Microsoft volume licensing price changes
Microsoft's plans to unify its volume licensing pricing policy across the European Union will leave resellers passing on potential price increases to customers. The vendor has made the decision to unify pricing from 1 July and there are expectations... News | 29 Mar 2012
Sage highlighted as takeover prospect
City watchers have raised expectations that Sage could be the target of a takeover stoking interest in the software firm. The vendor has been linked with M&A deals in the past, often with an expectation Sage will be involved, but the latest spec... News | 29 Mar 2012
Atlantis hunts Citrix partners for XenApp virtualisation push
Virtual Desktop Infrastructure (VDI) specialist Atlantis Computing is taking its first steps into the world of server virtualisation to coincide with the imminent migration off Citrix XenApp 4.5 servers running Windows 2003, and is looking to the Cit... News | 27 Mar 2012
Power firm caught out by BSA
The Business Software Alliance has struck again in its ongoing battle to punish those that fail to pay for using software landing a £8,000 settlement with power conversion specialist Coverteam. The payment breaks down to include a settlement p... News | 26 Mar 2012
Software license growth buoys Oracle
Decent levels of software license sales managed to keep things looking positive at Oracle despite the vendor's ongoing weakness on the hardware side of the business. The vendor revealed that new software license revenue was up by 7% for the three mon... News | 21 Mar 2012
SAP sets sights on database market dominance
SAP is set to make a major announcement next month as it outlines ambitions to become a major player in the database market. The vendor has set 10 April as the date it plans to reveal its strategy in a move that many are seeing as one that will heig... News | 16 Mar 2012
Blackpool builders latest to be stung by BSA
A Blackpool-based building services company has become the latest firm to be caught using unlicensed software and forced to pay out thousands to get itself on the right side of the law. The Business Software Alliance (BSA) has revealed that George M... News | 14 Mar 2012


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shamarone November 28, 2012 2:08 PM re: "But the initial impressions are good, with a better feel in the fuel mapping and throttle control."news flash leo, it's a placebo effect. not a bad thing, but it's still a blade. there's prolly little to no measurable difference. however, so long as you "think" there's a difference...? well then there is and that's all that matters. Reply Report abuse 0 agree 5 disagree
everybodyseemstoknoweverything - Unregistered November 28, 2012 3:20 PM thankyou Sigmund Freud for your observations!!!! 0 agree 0 disagree
Paul - Unregistered November 28, 2012 6:36 PM If I didn't have shams comments to laugh at I'd be pretty bored joker in the pack 0 agree 0 disagree


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Dr. Bogdan I. Neughebauer, MD
Infectious Disease, Sentara Medical Walk In And Urgent Care
- 850 Kempsville Rd
Norfolk, VA 23502 - 1 Office Location
- (757) 261-5910
Dr. Bogdan I. Neughebauer graduated from the Univ De Med Si Farm Grigore T Popa, Iasi, Romania in 1992. He works in Norfolk, VA and specializes in Infectious Disease. Dr. Neughebauer is affiliated with Sentara Princess Ann Hospital, Sentara Leigh Hospital and Sentara Norfolk General Hospital. He speaks English, French, Spanish and Tagalog.
Gender: Male
Years in Practice: 23 Years
Languages Spoken: English, French, Spanish, Tagalog
Medical School: Univ De Med Si Farm Grigore T Popa, Iasi, Romania
Graduation Date: 1992
Hospital Affiliations: Sentara Princess Ann Hospital, Sentara Leigh Hospital, Sentara Norfolk General Hospital
Specialties: Infectious Disease


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Original Article
Validity of the Morse Fall Scale implemented in an electronic medical record system
Article first published online: 21 SEP 2013
DOI: 10.1111/jocn.12359
© 2013 John Wiley & Sons Ltd
Additional Information
How to Cite
Baek, S., Piao, J., Jin, Y. and Lee, S.-M. (2014), Validity of the Morse Fall Scale implemented in an electronic medical record system. Journal of Clinical Nursing, 23: 2434–2441. doi: 10.1111/jocn.12359
Publication History
- Issue published online: 22 JUL 2014
- Article first published online: 21 SEP 2013
- Manuscript Accepted: 11 MAR 2013
Funded by
- Ministry of Education, Science and Technology. Grant Number: 2010-0027077
- Abstract
- Article
- References
- Cited By
- accidental fall;
- electronic medical record system;
- Morse Fall Scale;
- validity
Aims and objectives
To examine the validity of the Morse Fall Scale by analysing the electronic medical records on fall risk during different phases of hospitalisation.
Regular monitoring on fall risk with a reliable and valid assessment tool is a key element in the fall prevention. In Korea, the Morse Fall Scale is currently being used in numerous medical institutions, yet it has not been comprehensively evaluated whether it is suitable and valid.
The study design was a retrospective case–control study.
The participants included 151 fallers and 694 nonfallers. Data were extracted from a university hospital implementing Morse Fall Scale in the electronic medical records between October 2010 and June 2011. The nonfallers were selected by the stratified random sampling method among the patients who were in the hospital during the same period as the fallers. The Morse Fall Scale scores during three different time periods of hospital stay were used for analysis: the initial assessment score upon admission, the last and the maximum scores recorded from admission to the fall or discharge.
With the maximum Morse Fall Scale score and the best cut-off point of 51, validity indicators showed the highest performance: 0·72 for sensitivity, 0·91 for specificity, 0·63 for positive predictive value, 0·94 for negative predictive value, 0·63 for Youden Index and 0·77 for the area under the receiver operating characteristic curve.
The Morse Fall Scale showed relatively high predictive performance for the Korean population.
Relevance to clinical practice
The study results recommend practice change in fall prevention. As the validity was highest when the patient was first classified into the high-risk group based on the Morse Fall Scale cut-off score 51, patients classified as high risk should be placed under special nursing interventions until the day of their discharge, regardless of change in the patient state.


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CraigHicks's past comments
@some14some ... "people aged 70 and over should be banned from riding bicycle."
Check out this book blurb on amazon "More Than a Race: Four 70-Year-Old Cyclists Ride the Race Across America ... Leaving Oceanside CA on June 12, 2012, the team and their hard-working support crew of 15 raced to Annapolis MD in 6 days, 13 hours, 13 minutes, at an average of 19.04 mph. They not only broke the 70+ record by 27 hours, but also bested the 60+ record by more than 3 hours."
Not so many people can do that even in their youth. Mental and physical health is never guaranteed, but anyone can live a lifestyle which is more likely than not to result in their safely being able to ride a bicycle at 70+. You too!
Posted in: Gov't to tighten penalties for dangerous bicycle riding
For added context, it is worth pointing out that in 2014:
Imports from Japan to Korea = 4.6 billion $US Imports from Korea to Japan = 2.9 billion $US
From my own first hand experience I met many Koreans working in manufacturing industry, dealing on a regular basis with Japanese counterparts, who could speak communicable Japanese, and would enjoy business eating and drinking "parties" with Japanese. (In contrast virtually none of the Japanese spoke any Korean at all).
So while the political drama regularly appearing in the newspapers is true, it only shows one aspect of a larger picture.
Posted in: S Korea balks as U.S. picks Japan, Australia to service F-35s in Asia
Abe better hurry up with the war, or the revolution will come first.
Posted in: 'Black companies' getting worse
I see so many obese people walking or sitting around sipping on sports drink, which is just fructose and water. Without the "sports", it builds up fat cells but provides nothing to build up the extra immune system requirements for all that extra flesh, leaving the body open to all kinds of diseases (including cancer) that it cannot fight off properly.
I know this is just a single aspect of the problem, but it might be a good place to start.
Posted in: Obesity clips up to 8 years off your life, says study
@HonestDictator ... Easily impressionable idiots and mentally disturbed people are the only ones who would believe what's done in a fictional game is what should be done in real life.
"Easily impressionable" and "mentally disturbed" sounds like a stage of development that a lot of teenage boys have always gone through. So maybe you're right, and these games are indeed one factor in the surge of school shooting massacres.
Posted in: Australian retail giant pulls Grand Theft Auto V after protests
Maybe Takata should take the big step and switch away from ammonium nitrate, the explosive chemical which is used by Takata, and not used by any other airbag maker. Apparently ammonium nitrate allows for a more compact design, so if a car was designed around a smaller airbag supplied by Takata, that could pose a big problem. Might require changing the airbag, the steering wheel, and maybe even the steering column!
I can't imagine that any new car designs would include ammonium nitrate airbags in the near future.
Posted in: Inside Takata, tantrums, but little sense of crisis over air bags
This new years I got a room with a "sea view" booked in a west Izu pension, only 3,500 yen per person per night! Hopefully the sunrise is included in the view, otherwise we'll go down to the seashore to watch.
If you are stuck in Tokyo, the Chuo line and Keio line trains run special early trains out to Takao-san so you can watch the sunrise. BUT, if you go all the way to the top of Takao-san, where it is most crowded with people and a Shinto priest chants a prayer over loudspeakers, the trees block the view, so I find it better to choose a spot further down where the sunrise can be seen. Be prepared for low temperatures slightly below 0 c.
A Tokyo-to mountain for fantastic sunrises is Kumotori-san, whose peak is at the junction of Tokyo-to, Gifu pref., and Yamanashi pref. The peak is over 2000 meters high. There are two yama-goya (mountain huts with futons which charge a fee) available about 30 minutes down from the peak, and there is a "free" emergency shelter on the peak where you can sleep in a pinch but you should bring a sleeping bag. I've experienced pre dawn temperatures of -12 c, but I've heard it can get much lower than that. (If you stay in the "new" yama-goya which is on the dark side of the mountain you will need eizen spikes on your boots to walk down the icy slopes). From Okutama station there is a bus to Kamozawa, where a trail on the sunny of the mountain begins - 3 to 4 hours to the top walking.
Posted in: Tokyo metropolitan gov't building accepting applications to watch first sunrise of 2015
"Formaldehyde—a substance found in ... embalming fluids—was present at much higher levels than carcinogens found in the smoke from regular cigarettes, the official said."
This is pretty efficient. Pre-embalming while imbibing carcinogens will make the whole funeral process go more smoothly.
Posted in: E-cigarettes contain up to 10 times carcinogens: Japan researchers
In an unfortunate and unwise choice of strategy to locate Osama Bin Laden, information was gathered under the false front of an immunization program in Pakistan. In fact it yielded no information of value, but incurred a great and lasting cost on health care efforts in Pakistan and elsewhere, and unnecessarily put health workers lives at risk. Could it be that both Muslim terrorists and Muslim haters would prefer to see moderate peaceful thinkers of any religion killed? I would hope the answer is no, but then I cannot understand how such a misguided was formed.
Posted in: Four polio vaccinators shot dead in Pakistan
@WA4TKG ... Sorry, I am one of those DREADED NRA members you obviously HATE.
Sorry, I wouldn't waste my mental energy hating YOU when I need that mental energy to think logically and clearly. An exponential increase in gun rage incidents/accidents (sometimes committed by juveniles) is logically incompatible with "open carry" laws. Your logic is broken - HATE is not acceptable substitute for logic.
Posted in: 12-year-old boy with fake gun dies after shot by Ohio officer
@Kearimashita - ... prolifeation of diseases that spread to the wild population ...
If these are caused by virus or bacteria to which their farmed siblings are immune, it is likely the wild fish will eventually also develop immunity, especially if they interbreed.
Posted in: Surrogate sushi: Japan uses biotech for bluefin tuna
@WA4TKG ... When an ARMED Policeman is ( likely ) pointing HIS GUN at YOU, DO WHAT HE SAYS.
Unless you are an "open carry advocate" backed by the NRA. Then you strut your feathers, fully armed with guns and secret camera in front of policemen hoping they will stop you and your can post your video on you tube, as well as suing the police department.
Go search on you tube for "open carry", I got 726,000 hits. You won't be able to watch them as fast as they are being added. Who needs logic when you've got guns.
Posted in: 12-year-old boy with fake gun dies after shot by Ohio officer
There has been a trend, a global trend, clearly seen if compared to circumstances 60 years ago, to denigrate engineers and engineering, and replace them/it in management with financial wizards and wizardry. Since financial wizardry has no tools but to lower costs and float imaginary balloons, the resulting entropy inevitably leads to a collapse of quality, long term financial ruin, injury and death. It can be seen clearly in the Takata case, where Takata engineers were overruled by Takata management who were unable to grasp the engineering risk and unwilling to defer to those engineers who could.
Fortunately there are companies that buck this trend, so there may be light at the end of the tunnel.
Posted in: Plant with troubled past at center of Takata air bag probe
Of course I think she is -probably- a murderess because of the circumstantial evidence and motive. However, reporting "traces" of cyanide in the men's bodies and in the trash, is highly irresponsible. The case is now prejudiced - as in "already judged". As a matter of principle the police (anywhere) should err on the side of caution before releasing information, unless perhaps it is necessary for the purpose of protecting the public or gathering more information.
For example, the police leaked information that Yoshiyuki Kouno was the man who released poison gas in Matsumoto, killing seven (that number seven again!), sickening many more and sending even his own wife into a coma. It was revealed that Kouno had a large amount of pesticides stored at his residence. But it later turned out that Kouno was not involved at all, it was in fact a test run executed by Aum Shinri Kyo in preparation for their Kasumigaseki sarin attack.
Trace amounts. Many many people have been wrongly punished for trace amounts of opiates showing up in their blood tests, when the actual reason is substances in poppy seeds commonly found on bagels, rolls, breads, and in salad dressing. Here is a partial list of cases: http://www.snopes.com/medical/drugs/poppyseed.asp
Being thorough about justice is well worth the effort.
Posted in: Police find cyanide at home of 'black widow' suspect
"and reportedly recovered cyanide from her trash"
Cyanide is present in acetonitrile false fingernail remover, and false fingernails are popular in Japan.
Posted in: Police find cyanide at home of 'black widow' suspect
She wanted the man to be "elderly" and "living alone," the paper said, citing an investigator. She also made remarks suggesting that "it would be better if he has an illness".
This statement should actually work in her favor, as it indicates that her partners were already likely to be close to death, so it is not unusual that they should die soon.
Furthermore, arsenic is ever present in the environment, and in our own bodies. Levels vary between individuals by a factor of 100 or more [http://www.greenfacts.org/en/arsenic/l-2/arsenic-3.htm]. In the debate over whether Napoleon died of arsenic poisoning it has been argued that the traces of arsenic found in his hair could have come from his environment [http://www.napoleon-series.org/research/napoleon/c_arsenic.html]. So the statement "traces of arsenic" taken literally is not proof of anything. It should be "levels of arsenic impossible to occur naturally, 10,000? or whatever times the normal for smoking, fish eating, elderly Japanese gentlemen living in an industrial area".
Posted in: 'Black widow' still on hunt as husband No. 4 died: reports
@WillB ... ISIS represents 100% pure, fundamentalist, unadulterated, Sunni islam. Which is precisely why they attract to so many fanatical believers. You can dislike them, but you can not argue against them on religious grounds.
You appear to have allied yourself with ISIS - "you can not argue against them on religious grounds". Just what they need as weapon against the majority of Sunni Muslims who argue against them on religious grounds.
Whose side are you on?
Posted in: Beheading of U.S. aid worker in Syria draws condemnation
@donAlbert ... Anyway, if passengers on the back seats were wearing seat belts, they probably had bigger chances to survive than without strapping in.
From the pictures, I agree with donAlbert. The back seat area is intact.
In my opinion, from the safety point of view, the design of passenger seats in cars, trains, and planes is completely wrong. They should all be facing backwards - then the impact would be absorbed without slack evenly along the back from head to bottom - there would be many fewer injuries - even if seatbelts weren't being worn!
Posted in: Dump truck, minivan collide, leaving four dead in Chiba Prefecture
"unspecified objective evidence refuting the claims of both the alleged victim and the eyewitness"
This is very vague. It's entirely possible that there is not really sufficient evidence to either convict the man of rape or the woman/eyewitness of perjury.
Posted in: Man jailed for rape released after accuser's testimony proven false
I imagine one or both of the ladies failed to show the proper obsequious deference towards Ruiz on his birthday, which caused him to throw a murderous temper tantrum.
Posted in: Honduras beauty queen, sister found dead


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Gear Review
Wooden Robots
Mellow Plaid
Keep the plaid on the mellow side. Slight contrasting coloring throughout. A really tone down mellow looking short. Look good feel good.
the black is really nice, it fits fine but it is maybe a little bit tight, i bought it on 32 which is usually the size i use and would prefered a 34.
View More Details on Analog Oliver Short - Men's


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"Honey, ya gotta wanna kiss him," were the wise words of an older, drunk woman at Blondie's Sportsbar over a decade ago. And she was spot on.
Read Whole Story
LOS ANGELES -- Actor and filmmaker Zalman King, who became known for his erotic work after writing and producing his breakthrough film "9 1/2 Weeks,"...
Pat Metheny's new album is titled What's It All About, which is based off a line from the song "Alfie." Since this is an unusual approach for Pat Metheny, he tracked him down to talk about it.
Every time you stand in the grocery line, you see that same headline about the secret tips to the best sex ever. Like, ever ever. But buyer beware, because you may just run into a few snags along the way.
Get top stories and blog posts emailed to me each day..


text: ?Easy Sun Lounger? is the quality legendary selection for all easy riders & outlaws outthere. Born to be wild, born to be chillin', a cruisin' trip of loungism ambient music. Sublimely crafted by some of the biggest producers around, including Cinemascope, Aqualise, Fancy Vienna, Lazy Hammock, Andrea Depp, Newton, 351 Lake Shore Drive and many many more freedism' productions. ?Easy Sun Lounger? is designed for a long road trip full of great music, to share with your motorcycle buddies the Route 66 . 20 wonderful lounge and chill out productions, plus an additional DJ MIX by the great rebellious lounge protagonist SMOOTH DELUXE !


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Business schools historically have focused on how to produce effective leaders. Increasingly we have to ask whether the organisations are responsible
53% of women who started out in a business role in a tech-intensive industry post-MBA left to take a position in another industry.
Colin Goodman, Darrell Read and Danny Wilkinson entered their pleas at London's Southwark Crown Court on Friday.
Mars robot Beagle 2 tried to make a soft touchdown on the red soil of Mars on Christmas of 2003, but no radio contact was ever made with the probe.
SC issued notice to Guj govt on a plea seeking compensation to families of debt-ridden 619 farmers who have allegedly committed suicide since 2003.
A British-built space probe that disappeared without trace more than a decade ago has been spotted on the surface of Mars- UK Space Agency
Amazon.com Inc said on Friday it drew more than 10 million new members to its Prime shipping and digital content service over the holidays and intends to offer one-hour shipping to more cities in 2015.
Western Australia state, once the "economic engine" of Australia, recorded its first budget deficit in 15 years as royalties from iron ore plummet.


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Deniz Huysal, editor-in-chief of T+L's Turkish edition, shares her favorite detours beyond Istanbul.Europe's Most-Visited Tourist Attractions
The new European Grand Tour counts museums, ancient ruins, churches, and some surprises.How to Plan a Trip on a Whim
When it comes to trip-planning, I tend to get serious: My husband E. would tell you that I sometimes spend too much time on pre-trip...Patricia Urquiola's Packing Checklist
The architect and designer opens her (well-edited) suitcase. "The less I pack, the more relaxed I feel," says the Spanish-born, Milan-based designer, known for...Insider Shopping Guide to Istanbul
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Living up to its moniker Istancool, Turkey's capital has a trio of stylish new places to stay. Channel your inner sultan at Hôtel Les Ottomans...Europe's Most Irresistible Restaurants
T+L's dining critic continues the European restaurant tour she first embarked on two decades ago.It List: The Best New Hotels 2011
From a pioneering farmstead in South Africa to a sexy Manhattan skyscraper, these are the year's best new hotels.World's Best Hotels 2012
The results of the annual Travel + Leisure survey are in! Which are the world's best hotels of 2012?Hoteliers Reinventing the Boutique Hotel
With their intimate, unconventional properties around the globe, these six trailblazers are transforming the boutique hotel.


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"I have two nieces (sisters) that are expecting within a couple of months of the other, so decided for the benefit of the guests (90% would have been invited to both showers) to do a joint shower. I was worried that creating an invitation would be tricky, but this was perfect. Both Moms-to-be were thrilled! The envelope option was a bonus."
"Awesome invitations and I liked that I was able to change the fonts and wording a bit to fit our event. Very happy with the quality of the product and also with the customer service department when I called in. Will definitely recommend to family and friends."
"This invite (sample) surpassed my expectations. High quality paper, lovely illustration…. I will be ordering these for my daughters baby shower in November."
"The quality and color was beautiful on this invitation. I love the rounded corners and square shape. My friend isn't finding out whether she's having a boy or girl, so the yellow really grabbed me. I was very pleased with how fast they arrived (3 days)."
"This invitation turned out perfect! The quality of the product is very well. I personalized it for a couples shower, and had tinyprints address/ship the invitations directly to the guests."


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Hot answers tagged libgdx
Storing the completion information in a local file is a simple and perfectly acceptable method of doing so. Fundamentally, this is what every game will do to track progress (in some fashion, although the specific formats used for the data and the storage mechanism will differ).
Protecting the file from tampering is more difficult. If there's no compelling ...
You can create a replay file as proof of work while the player is playing. Start the game, save the starting conditions including the name of the level and the pseudorandom seed, record the exact timestamped input states (mouse movements, key or button presses, etc.) that your game's input layer passes to its logic layer, and stop recording once the ...
Here's a vector-based solution. I haven't tried it, but it seems fine conceptually.
I gather you've stored the shape as line segments. Here's the letter A represented with three line segments.
I've assumed that paths in the user's drawing are stored as lists of points.
We can "inflate" those line segments to allow an error margin when checking ...
Sarting with the clouds, a simple method is to draw them as three layers:
Layer 1 is the bottom layer, and is drawn first. It just contains the cyan background.
Layer 2 is the middle layer, drawn between the other two, and it represents the 3D highlights. The background in this layer would again be transparent (represented by a purple colour in the ...
You could achieve this effect using parallax scrolling by making the earth and each shade of green a separate layer. With a parallax effect, no 3D calculations are required, and you get to stay with the pixelated, simple color style you're using.
Note that parallax doesn't have to be limited to just horizontal motion. Vertical movement (when the camera ...
If you want to do this totally in the client side and you don't consider the private storage provided by your platform to be secure enough (e.g. if there's actual money involved in completing levels), what you need is a proof of work. Your save file must contain an information that is designed such that creating the information is difficult to calculate ...
I use Interpolation.bounceIn.apply(current_position, target_position, smoothness) to achieve this effect. Take a look at this.
Edit I found the answer on their site
MoveToAction action = Actions.action(MoveToAction.class);
action.setPosition(x, y);
That spacing is called font kerning. And that is exactly why there is padding in front. The purpose of kerning is so that letters fit nicely next to each other, and that they aren't too close or too far away from each other.
This issue happens with some MSAA or CSAA implementations.
Try disabling anti-aliasing and see if it goes away.
If that is the case you might need to force multi-sampling resolve before rendering your transparency.
The other solution would be to force some overlap of your tiles.
This problem is usually a sound design problem, not a coding problem. These problems occur mostly because of insufficient use of random variations in sound samples.
You should first make sure you are using a pool of different recordings of the same sound and play a random one each time you fire a bullet, or make small random variations of the pitch on the ...
Check out the principles behind stencil buffers and/or masking.
Essentially what you want to do is generate a mask/stencil to mark out your drawing area and use this mask to decide if the user can draw or not.
For example, take your shapes you want the user to draw on and render them as pure white into a full-screen buffer, with a default colour of black. ...
In this line
ball.applyLinearImpulse(new Vector2(0f, 5000f), ball.getPosition(), true);
I think the point where you put force it relative to object position, so you put impule in
ball.getPosition() + ball.getPosition()
Try to use
public void applyForceToCenter(Vector2 force, boolean wake)
ball.applyLinearImpulse(new Vector2(0f, 5000f), new ...
How the author specifically got that value was via experimentation. From the comments:
Q: Hi James, you set acceleration.y to 460. How did you find this number? Is it static?
A: Acceleration was experimentally determined. Its value does not change.
And this is often the case when determining values for your game. You pick a value and play-test ...
I suggest moving the target slowly rather than the angle. Try this:
Vector2 Target;
// Interp is a value between 0 and 1. When 0, the target never moves.
// When 1, the target moves instantaneously. Intermediate values cause the target
// to move at different rates.
void UpdateTarget(float interp)
Target = interp * Mouse.Position + (1 - interp) * ...
I think any linear function would be fine for this. You can keep two variables one for your spaceship's current angle spaceshipAngle = Math.PI*k, and one for the current angle that the user inputs with his cursor cursorAngle = Math.PI*p. And what you do is
if (Math.Abs(Math.PI*k, Math.PI*p) < Math.PI)
if (Math.PI*k < Math.PI*p)
k += ...
The conversion from a unit to another is a matter of a simple multiplication. You can implement a ConvertUnits static class with functions like ConvertToGameUnits(), and ConvertToBox2DUnits() to make it easier.
I haven't used libgdx or Box2D, but i have used Farseer Physics engine which is basically identical with box2D but made for C#. With that being ...
What makes you think this is the shader code that is slow ? In most machines nowadays, and especially mobile devices, the bottlenecks are not these purely calculation-fed (ALU loaded) shaders, but memory bandwidth.
Memory bandwidth is used by framebuffers being fed to shaders as textures, or by the ROPs writing to the render target. Especially bad when ...
If you prefer using an external file to hold save information and it is in a place that would be tamper-able by users you may want to read up on how encryption works and use that to prevent anyone from being able to make meaningful changes to the file.
Something like a Feistel Cipher should be a good starting point and would be sufficient to stop someone ...
To get rid of the lines, you need to set Pixmap.setBlending(Blending.NONE); before you draw the circle.
You should not do it like that. Use scene2d for your buttons and menus and use InputMultiplexer to set up multiple input processor.
If you let your library scale down the textures and drop the originals from memory then you will not have any problems with memory consumption. Your load times will however increase drastically, along with the download size and storage space needed for your game.
If you are going to ship on phones then you should definitely scale your textures lower than ...
I've never used libGDX but textures Cost a lot of memory in general.
Which isn't a big deal on PC but you have to watch out with mobile devices which have limited resources.
Let's say you have a device with 256MB of memory, you have 10 textures in your scene and each texture is about 8MB (assuming we're using 2048x2048 32-bit png).
Thats using about 30% of ...
With a camera you separate your game measurements from the screen size and ratio.
It is not always better. If you make a board game for example, you can just fit it to the width of the screen, the view will never move anyway.
When using pixels to measure, you have no floating point positions.
By the way i made a full pong like game without a camera.
When browser the libgdx documentation (for example at http://libgdx.badlogicgames.com/nightlies/docs/api/com/badlogic/gdx/maps/MapLayer.html), I don't see any mention of the image layer, so most likely this relatively new (and still quite limited) layer type is not supported by libgdx yet.
If you would like to see this supported in libgdx, I suggest opening ...
Gdx.gl.glClear : as .glClear suggests, this function clears the screen before drawing the next frame.
It depends where do you instantiate your font object (as you're using libgdx I guess you use BitmapFont to create your font object).
An approach could be to instantiate it in the main class (the one that extends Game), and whenever you want to draw it on ...
Only top voted, non community-wiki answers of a minimum length are eligible


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Space Is (Not) the Place, Says Professor 376
from the maybe-not-yet dept.
Want to read Slashdot from your mobile device? Point it at m.slashdot.org and keep reading!
Space is dark
It's hard to find
A place to park
Burma Shave
...the right thing with false reasoning.
There is no economic reason to colonize space. In fact, there is no economic reason for anything other than killing all people and let the last remaining person to live the remainder of his life as the supposed owner of the world. Here is your perfect solution, the whole Earth population (1 person) acquiring maximum possible amount of all possible resources and products per time (whatever he can lay his eyes on). But this is why economists should shut up and go back to whoring to the aristocracy. Hey, look, Austrian School is unpopular again, you have some work to do!
This is all ridiculous. The reason we aren't going to space is because we're a bunch of cowards--we insist that any mission have a ridiculously high safety expectation, complete with trip home.
We aren't going to even BEGIN to think about living anywhere outside our planet until someone driven enough to risk their life sits on top of a ton of explosives and fires themselves off to the stars with two middle fingers pointing back at the receding Earth.
Can imagine the crap she gets when she suggests maybe they should go on a cruise or buy a new car?
Sorry, I should have put a
Of course, after thinking about it - no one in government reads anything other than dry reports. There's probably not a decision maker anywhere who knows who Heinlein was. And, I don't think Harsh Mistress made it to Hollywood, so we're probably safe if we suggest a catapult!
If a thing's worth doing, it is worth doing badly. -- G.K. Chesterton


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Printable Area
By cookiedog on February 11, 2008
Photo by cookiedog
Photo by cookiedog
"These are little steamed dumplings that are usually served for brunch. When I make them, I usually serve them with some steamed rice and call it dinner! Unlike most dumplings, Siu Mai do not completely cover all of the filling- some of the filling should peak out from the top. Siu Mai (Su My) wraps are thinner than most wonton wrappers. These are a little time consuming to make, and I wouldn't suggest making them after a busy day at work. If you enjoy cooking, than you will like this recipe! I really love them with the Mustard Soy Dipping Sauce I have posted on zaar as well. From Martin Yan's Chinatown Cooking."
Serving Size: 1 (1646 g)
Servings Per Recipe: 1
"Delicious! Looked so pretty with the peas and carrots on top. I actually made these about a year ago and haven't had a chance to review. Reminded me of dim sum with my family."
"Very good as was the Mustard Soy sauce. Made for Chinese New Year Dimsum for my Red Hat group. Everyone liked these and I'll be making them again. Used ground turkey 'cause that's what I had in the freezer and some shrimp."


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Publications (77)327.8 Total impact
Conference Paper: Dynamic Programming for Set Data Types
[Show abstract] [Hide abstract]
ABSTRACT: We present an efficient generalization of algebraic dynamic programming (ADP) to unordered data types and a formalism for the automated derivation of outside grammars from their inside progenitors. These theoretical contributions are illustrated by ADP-style algorithms for shortest Hamiltonian path problems. These arise naturally when asking whether the evolutionary history of an ancient gene cluster can be explained by a series of local tandem duplications. Our framework makes it easy to compute Maximum accuracy solutions, which in turn require the computation of the probabilities of individual edges in the ensemble of Hamiltonian paths. The expansion of the Hox gene clusters is investigated as a show-case application. For implementation details see: http://www.bioinf.uni-leipzig.de/Software/setgram/Lecture Notes in Bioinformatics (Brazilian Symposium on Bioinformatics, BSB 2014); 10/2014 - [Show abstract] [Hide abstract]
ABSTRACT: The elucidation of orthology relationships is an important step both in gene function prediction as well as towards understanding patterns of sequence evolution. Orthology assignments are usually derived directly from sequence similarities for large data because more exact approaches exhibit too high computational costs. Here we present PoFF, an extension for the standalone tool Proteinortho, which enhances orthology detection by combining clustering, sequence similarity, and synteny. In the course of this work, FFAdj-MCS, a heuristic that assesses pairwise gene order using adjacencies (a similarity measure related to the breakpoint distance) was adapted to support multiple linear chromosomes and extended to detect duplicated regions. PoFF largely reduces the number of false positives and enables more fine-grained predictions than purely similarity-based approaches. The extension maintains the low memory requirements and the efficient concurrency options of its basis Proteinortho, making the software applicable to very large datasets.PLoS ONE 08/2014; 9(8):e105015. · 3.53 Impact Factor -
Article: The CHR site: definition and genome-wide identification of a cell cycle transcriptional element.
[Show abstract] [Hide abstract]
ABSTRACT: The cell cycle genes homology region (CHR) has been identified as a DNA element with an important role in transcriptional regulation of late cell cycle genes. It has been shown that such genes are controlled by DREAM, MMB and FOXM1-MuvB and that these protein complexes can contact DNA via CHR sites. However, it has not been elucidated which sequence variations of the canonical CHR are functional and how frequent CHR-based regulation is utilized in mammalian genomes. Here, we define the spectrum of functional CHR elements. As the basis for a computational meta-analysis, we identify new CHR sequences and compile phylogenetic motif conservation as well as genome-wide protein-DNA binding and gene expression data. We identify CHR elements in most late cell cycle genes binding DREAM, MMB, or FOXM1-MuvB. In contrast, Myb- and forkhead-binding sites are underrepresented in both early and late cell cycle genes. Our findings support a general mechanism: sequential binding of DREAM, MMB and FOXM1-MuvB complexes to late cell cycle genes requires CHR elements. Taken together, we define the group of CHR-regulated genes in mammalian genomes and provide evidence that the CHR is the central promoter element in transcriptional regulation of late cell cycle genes by DREAM, MMB and FOXM1-MuvB.Nucleic Acids Research 08/2014; · 8.81 Impact Factor -
Conference Paper: Analyzing Chromatin Using Tiled Binned Scatterplot Matrices
[Show abstract] [Hide abstract]
ABSTRACT: Background: Over the last years, more and more biological data became available. Besides the pure amount of new data, also its dimensionality - the number of different attributes per data point - increased. Recently, especially the amount of data on chromatin and its modifications increased considerably. In the field of epigenetics, appropriate visualization tools designed for highlighting the different aspects of epigenetic data are currently not available. Results: We present a tool called TiBi-Scatter enabling correlation analysis in 2D. This approach allows for analyzing multidimensional data while keeping the use of resources such as memory small. Thus, it is in particular applicable to large data sets. Conclusions: TiBi-Scatter is a resource-friendly and easy to use tool that allows for the hypothesis-free analysis of large multidimensional biological data sets.4th Symposium on Biologial Data Visualization, Boston, MA, USA; 07/2014 -
Conference Paper: Comparative Detection of Processed Small RNAs in Archaea
[Show abstract] [Hide abstract]
ABSTRACT: Enzymatic splicing in Archaeal tRNAs is guided by bulge-helix-bulge structural elements, while much less seems to be known about splicing in other small RNAs (sRNAs). We conduct a genome-wide analysis of several archaeal genomes to identify putative BHB elements and compare our findings with available RNA-seq data. We also provide an analysis of the viability of using pattern-based and stochastic structural scanning algorithms for in silico studies of the occurrence of BHB motifs. Furthermore, we comment on splicing motifs in other small RNAs, which mostly do not fit the pattern of bulge-helix-bulge motifs. Appendix and supporting files available at: http://www.bioinf.uni-leipzig.de/publications/supplements/14-001IWBBIO 2014 (2nd International Work-Conference on Bioinformatics and Biomedical Engineering); 04/2014 -
Dataset: binder 2013-epi
- [Show abstract] [Hide abstract]
ABSTRACT: Most investigations into the large-scale patterns of protein evolution are based on gene annotations that have been compiled in reference databases. The use of these resources for quantitative comparisons, however, is complicated by sometimes vast differences in coverage. More importantly, however, we also observe substantial ascertainment biases that cannot be removed by simple normalization procedures. A striking example is provided by the correlations between protein domains. We observe that statistics derived from different computational gene annotation procedure show dramatic discrepancies, and even qualitative changes from negative to positive correlation, when compared to statistics obtained from annotation databases.Malaysian Journal of Fundamental and Applied Sciences. 07/2013; 10(2). - [Show abstract] [Hide abstract]
ABSTRACT: Eukaryotic histones carry a diverse set of specific chemical modifications that accumulate over the life-time of a cell and have a crucial impact on the cell state in general and the transcriptional program in particular. Replication constitutes a dramatic disruption of the chromatin states that effectively amounts to partial erasure of stored information. To preserve its epigenetic state the cell reconstructs (at least part of) the histone modifications by means of processes that are still very poorly understood. A plausible hypothesis is that the different combinations of reader and writer domains in histone-modifying enzymes implement local rewriting rules that are capable of "recomputing" the desired parental modification patterns on the basis of the partial information contained in that half of the nucleosomes that predate replication. To test whether such a mechanism is theoretically feasible, we have developed a flexible stochastic simulation system (available at http://www.bioinf.uni-leipzig.de/Software/StoChDyn) for studying the dynamics of histone modification states. The implementation is based on Gillespie's approach, i.e., it models the master equation of a detailed chemical model. It is efficient enough to use an evolutionary algorithm to find patterns across multiple cell divisions with high accuracy. We found that it is easy to evolve a system of enzymes that can maintain a particular chromatin state roughly stable, even without explicit boundary elements separating differentially modified chromatin domains. However, the success of this task depends on several previously unanticipated factors, such as the length of the initial state, the specific pattern that should be maintained, the time between replications, and chemical parameters such as enzymatic binding and dissociation rates. All these factors also influence the accumulation of errors in the wake of cell divisions.Journal of Theoretical Biology 07/2013; · 2.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.Nature 04/2013; 496(7445):311-316. · 42.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.Nature 04/2013; 496(7445):311-316. · 42.35 Impact Factor - Physical Biology 03/2013; · 3.14 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Chromatin-related mechanisms, as e.g. histone modifications, are known to be involved in regulatory switches within the transcriptome. Only recently, mathematical models of these mechanisms have been established. So far they have not been applied to genome-wide data. We here introduce a mathematical model of transcriptional regulation by histone modifications and apply it to data of trimethylation of histone 3 at lysine 4 (H3K4me3) and 27 (H3K27me3) in mouse pluripotent and lineage-committed cells. The model describes binding of protein complexes to chromatin which are capable of reading and writing histone marks. Molecular interactions of the complexes with DNA and modified histones create a regulatory switch of transcriptional activity. The regulatory states of the switch depend on the activity of histone (de-) methylases, the strength of complex-DNA-binding and the number of nucleosomes capable of cooperatively contributing to complex-binding. Our model explains experimentally measured length distributions of modified chromatin regions. It suggests (i) that high CpG-density facilitates recruitment of the modifying complexes in embryonic stem cells and (ii) that re-organization of extended chromatin regions during lineage specification into neuronal progenitor cells requires targeted de-modification. Our approach represents a basic step towards multi-scale models of transcriptional control during development and lineage specification.Physical Biology 03/2013; 10(2):026006. · 3.14 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Current genome-wide ChIP-seq experiments on different epigenetic marks aim at unraveling the interplay between their regulation mechanisms. Published evaluation tools, however, allow testing for predefined hypotheses only. Here, we present a novel method for annotation-independent exploration of epigenetic data and their inter-correlation with other genome-wide features. Our method is based on a combinatorial genome segmentation solely using information on combinations of epigenetic marks. It does not require prior knowledge about the data (e.g. gene positions), but allows integrating the data in a straightforward manner. Thereby, it combines compression, clustering and visualization of the data in a single tool. Our method provides intuitive maps of epigenetic patterns across multiple levels of organization, e.g. of the co-occurrence of different epigenetic marks in different cell types. Thus, it facilitates the formulation of new hypotheses on the principles of epigenetic regulation. We apply our method to histone modification data on trimethylation of histone H3 at lysine 4, 9 and 27 in multi-potent and lineage-primed mouse cells, analyzing their combinatorial modification pattern as well as differentiation-related changes of single modifications. We demonstrate that our method is capable of reproducing recent findings of gene centered approaches, e.g. correlations between CpG-density and the analyzed histone modifications. Moreover, combining the clustered epigenetic data with information on the expression status of associated genes we classify differences in epigenetic status of e.g. house-keeping genes versus differentiation-related genes. Visualizing the distribution of modification states on the chromosomes, we discover strong patterns for chromosome X. For example, exclusively H3K9me3 marked segments are enriched, while poised and active states are rare. Hence, our method also provides new insights into chromosome-specific epigenetic patterns, opening up new questions how "epigenetic computation" is distributed over the genome in space and time.PLoS ONE 10/2012; 7(10):e46811. · 3.53 Impact Factor -
Article: Modeling the dynamic epigenome: from histone modifications towards self-organizing chromatin.
[Show abstract] [Hide abstract]
ABSTRACT: Epigenetic mechanisms play an important role in regulating and stabilizing functional states of living cells. However, in spite of an increasing amount of experimental data, models of transcriptional regulation by epigenetic processes, in particular by histone modifications, are rather rare. In this article, we focus on epigenetic modes of transcriptional regulation based on histone modifications and their potential dynamical interplay with DNA methylation and higher-order chromatin structure. The main purpose of this article is to review recent formal modeling approaches to the dynamics and propagation of histone modifications and to relate them to available experimental data. We evaluate their assumptions with respect to recruitment of relevant modifiers, establishment and processing of modifications, and compare the emerging stability properties and memory effects. Theoretical predictions that await experimental validation are highlighted and potential extensions of these models towards multiscale models of self-organizing chromatin are discussed.Epigenomics 04/2012; 4(2):205-19. · 2.43 Impact Factor - IDS Bulletin. 01/2012;
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ABSTRACT: The transitions to multicellularity mark the most pivotal and distinctive events in life's history on Earth. Although several transitions to "simple" multicellularity (SM) have been recorded in both bacterial and eukaryotic clades, transitions to complex multicellularity (CM) have only happened a few times in eukaryotes. A large number of cell types (associated with large body size), increased energy consumption per gene expressed, and an increment of non-protein-coding DNA positively correlate with CM. These three factors can indeed be understood as the causes and consequences of the regulation of gene expression. Here, we discuss how a vast expansion of non-protein-coding RNA (ncRNAs) regulators rather than large numbers of novel protein regulators can easily contribute to the emergence of CM. We also propose that the evolutionary advantage of RNA-based gene regulation derives from the robustness of the RNA structure that makes it easy to combine genetic drift with functional exploration. We describe a model which aims to explain how the evolutionary dynamic of ncRNAs becomes dominated by the accessibility of advantageous mutations to innovate regulation in complex multicellular organisms. The information and models discussed here outline the hypothesis that pervasive ncRNA-based regulatory systems, only capable of being expanded and explored in higher eukaryotes, are prerequisite to complex multicellularity. Thereby, regulatory RNA molecules in Eukarya have allowed intensification of morphological complexity by stabilizing critical phenotypes and controlling developmental precision. Although the origin of RNA on early Earth is still controversial, it is becoming clear that once RNA emerged into a protocellular system, its relevance within the evolution of biological systems has been greater than we previously thought.Origins of Life 12/2011; 41(6):587-607. · 2.05 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: High-throughput experiments have produced convicing evidence for an extensive contribution of diverse classes of RNAs in the expression of genetic information. Instead of a simple arrangement of mostly protein-coding genes, the human transcriptome features a complex arrangement of overlapping transcripts, many of which do not code for proteins at all, while others "sample" exons from several different "genes". The complexity of the transcriptome and the prevalence of noncoding transcripts forces us to reconsider both the concept of the "gene" itself and our understanding of the mechanisms that regulate "gene expression".Biophysical Reviews and Letters 11/2011; 03(01n02). -
Conference Paper: Evolution of domain co-occurrences: some striking results
26th German Conference on Bioinformatics 2011. 7-9 September 2011; 09/2011 - [Show abstract] [Hide abstract]
ABSTRACT: Functional RNA elements can be embedded also within exonic sequences coding for functional proteins. While not uncommon in viruses, only a few examples of this type have been described in some detail for eukaryotic genomes. Here we use RNAz and RNAcode, two comparative genomics methods that measure signatures of stabilizing selection acting on RNA secondary structure and peptide sequence, resp., to survey the fruit fly genomes. We estimate that there might be on the order of 1000 loci that are subject to dual selection pressure. The used genome-wide screens also expose the limitations of the currently available methods.Biochimie 07/2011; 93(11):2019-23. · 3.14 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Teleost fishes have extra Hox gene clusters owing to shared or lineage-specific genome duplication events in rayfinned fish (actinopterygian) phylogeny. Hence, extrapolating between genome function of teleosts and human or even between different fish species is difficult. We have sequenced and analyzed Hox gene clusters of the Senegal bichir (Polypterus senegalus), an extant representative of the most basal actinopterygian lineage. Bichir possesses four Hox gene clusters (A, B, C, D); phylogenetic analysis supports their orthology to the four Hox gene clusters of the gnathostome ancestor. We have generated a comprehensive database of conserved Hox noncoding sequences that include cartilaginous, lobe-finned, and ray-finned fishes (bichir and teleosts). Our analysis identified putative and known Hox cis-regulatory sequences with differing depths of conservation in Gnathostoma. We found that although bichir possesses four Hox gene clusters, its pattern of conservation of noncoding sequences is mosaic between outgroups, such as human, coelacanth, and shark, with four Hox gene clusters and teleosts, such as zebrafish and pufferfish, with seven or eight Hox gene clusters. Notably, bichir Hox gene clusters have been invaded by DNA transposons and this trend is further exemplified in teleosts, suggesting an as yet unrecognized mechanism of genome evolution that may explain Hox cluster plasticity in actinopterygians. Taken together, our results suggest that actinopterygian Hox gene clusters experienced a reduction in selective constraints that surprisingly predates the teleost-specific genome duplication.Journal of Experimental Zoology Part B Molecular and Developmental Evolution 06/2011; 316(6):451-64. · 2.12 Impact Factor
Publication Stats
2k | Citations | |
327.80 | Total Impact Points | |
Top Journals
University of Leipzig
- • Interdisziplinäres Zentrum für Bioinformatik
- • Institut für Informatik
Leipzig, Saxony, Germany
Harvard University
Cambridge, Massachusetts, United States
Philipps University of Marburg
- Institut für Pharmazeutische Chemie
Marburg, Hesse, Germany -
University of Vienna
- Department of Theoretical Chemistry
Vienna, Vienna, Austria
Benaroya Research Institute
Seattle, Washington, United States -
Shanghai Institutes for Biological Sciences
Shanghai, Shanghai Shi, China -
Santa Fe Institute
Santa Fe, New Mexico, United States
University of Freiburg
- Bioinformatics
Freiburg, Lower Saxony, Germany
Arizona State University
- Department of Biomedical Informatics
Phoenix, Arizona, United States
Georg-August-Universität Göttingen
- Institute of Microbiology and Genetics
Göttingen, Lower Saxony, Germany
Yale University
- Department of Ecology and Evolutionary Biology
New Haven, CT, United States


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Synopsis: Residents of Los Angeles go about their day unaware that a mysterious event is about to change their lives. FBI agents Mark Benford and Demetri Noh are in a car chase; Benford's physician wife is in the middle of surgery; and Benford's friend Aaron Stark works on power lines high above the ground. Suddenly, something causes everyone in the world to black out for just over two minutes. During that time, each person sees a series of events in his or her own future -- some good, some bad, some apparently nonexistent. As people begin to piece together their visions on a worldwide website, Mark and Demetri use the information to try to pinpoint the cause of the blackout, and people are still trying to determine whether destiny can be changed, and what effect those changes may have on others.
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Language: English Release Date: 24 September 2009 Genres: Drama, Mystery Theme: Discovery,Mystery Time Period: 2000s,2010s
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The biggest reveals in the 'Game of Thrones' Season 5 photos
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Barbizon Grads had the opportunity to promote Eco- Friendly Eifi Designs and spend the day raising Environmental Awareness.
Taylor Blackistone, a Barbizon alum from Chesapeake Beach, MD, recently signed with W Model Management.
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text: Space Jam Inspired Art Exhibition Hits NYC Space Jam Inspired Art Exhibition Hits NYC SMU notified of allegations by NCAA SMU notified of allegations by NCAA Chargers WR Keenan Allen potentially out for rest of th... Chargers WR Keenan Allen potentially out for rest of th... Jon Lester featured on this week's Sports Illustrated c... Jon Lester featured on this week's Sports Illustrated c... Marcus Mariota shines on Letterman Marcus Mariota shines on Letterman Bobby Petrino's unique bonus Bobby Petrino's unique bonus Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire Tigers catcher Alex Avila will play in ALCS Game 6 two days after collision by Brian Kotloff Email Posted: Sat Oct. 19, 2013 Tigers catcher Alex Avila strained the patellar tendon in his left knee during a collision with David Ross on Thursday. (Ronald Martinez/Getty Images)Two days after suffering a knee injury in a violent collision at home plate, Detroit Tigers catcher Alex Avila will play in Game 6 of the American League Championship Series against the Boston Red Sox on Saturday, Tigers manager Jim Leyland said at his pregame press conference.Avila strained the patellar tendon in his left knee when Boston catcher David Ross barreled over him during a play at the plate on Thursday.He initially stayed in the game, but was replaced by backup Brayan Pena before his at-bat the next inning.Avila, who started 96 games at catcher in his fifth year with the Tigers, is considered the team's best defensive option behind the plate. The left-handed hitter is 5 for 27 with one home run in the postseason while starting each of Detroit's 10 games.Leyland provided an update on Avila's status on Saturday afternoon (via ASAPSports.com):"I have talked to him. I got on the plane with him yesterday. I just left him in the trainer's room ten minutes ago. He's ready to go. He feels pretty good. I don't think that will be any kind of a drawback where you're going ‑‑ the main thing from a manager's standpoint the one thing you don't want to happen is when you're dealing with an injury ‑‑ and I think Alex is fine now ‑‑ the one thing you don't want to happen is start the game and take him out in the second or third inning. That's one thing I try to guard against as a manager. If you can't go, that's fine; but if you can go, you want to be out for the entire game, if possible.CORCORAN: ALCS Preview: Tigers at Red Sox, Game 6 LEMIRE: Running Red Sox looking for an advantage one base at a time Promoted Stories Comments


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I took my husband to see a show in Interlochen, MI, at the beginning of July. He was happy to drive me to visit Cedar Hedge Garden.
I finally got around to uploading the pics and made a slideshow. Just click on the link. The link is at the end of this post. Also, here are a few of my favorite hostas from the trip!
Here is a link that might be useful: Cedar Hedge Garden slideshow
Follow-Up Postings:
Thanks for sharing all this beauty. |
- Posted by steve_mass 5b (My Page) on Tue, Jul 24, 12 at 14:01
Beautiful specimens, grown well. Thanks for the pics. Steve |
- Posted by hostahillbilly Zone 4 (My Page) on Thu, Jul 26, 12 at 0:54
This place is within, about, a half hour from us, and we often enjoy visiting Donna, as she's a wild and crazy fun person. There's another 'hosta plase' very near there that we avoid, like a passion, but don't let that oft-mentioned b bad-attitude place keep you from spending the time and effort to go see the fun at Cedar Gardens hostas! Oh how we wish we lived where she does and can 'steal' the water from the lake she lives on. Ahhh, another life, we should live on a lake where we could git the water without the DNR busting us, dreaming. hh |
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From: Today
You can leave the apples in for longer in the cooling oven to crisp up more
From: Neven Maguire: Home Chef
If you prefer to bake the goat's cheese, simply cook it in an oven preheated to 180°C (350°F/gas mark 4) for another 5-10 minutes, until warmed through and soft. Look for Irish apples in the supermarket, particularly when they are in season, and if they're not there, ask the manager why! Apples are one of our few indigenous fruits and there is no excuse for the shops not supporting Irish farmers.
From: Four Live
Sometimes a bowl of these in the middle of a table at a drinks reception is just enough.
From: Kitchen Hero: Donal's Irish Feast
If you are looking for a slightly different starter this Christmas, this salmon gravadlax recipe is an ideal solution and can all be made well in advance, leaving very little to do last minute.
From: Today
Allow to cool slightly before serving.


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Select Contacts> Options > Settings > Contacts to Display > Phone memory.
Nokia 5233 - Why is the contact photo not displayed on my Nokia device?
Related FAQs
- How can I connect Nokia Symbian or Nokia S40 phone to my computer?
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- What can I do if my Nokia Symbian phone memory is low?
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- How do I calibrate the thouch screen on my Nokia Symbian (S60) phone?


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Mobility has become an important aspect of the customer experience, and customer care leaders must craft a specific mobile customer experience (CX) if they want to keep pace with customer needs and expectations. That means understanding the mobile customer, defining a mobile CX strategy, and putting that plan into place.
This year the number of mobile devices will exceed the world's population and global mobile data traffic will increase 18-fold between 2011 and 2016, according to a recent Cisco report. This means a growing percentage of the time customers engage with a company will be through a mobile device.
When crafting a mobile CX strategy, one of the most important steps is defining how the business's actual customers use mobile devices in relation to the company, according to Angel, a customer engagement solutions provider that blogs on the topic.
"For example, customer care teams should examine how the customer base usually interacts with the business throughout the entire lifecycle – and what characteristics are specific to the mobile customer," Angel noted in a recent blog post.
Questions that customer care leaders should ask when defining their mobile users, according to Angel, include whether there are core questions customers usually ask; whether there are certain services, products or content that are accessed more on mobile devices; what usual customer issues can be solved through automation; what issues consistently require a customer service representative; whether customers need support at the beginning of after a few months of using the company's product; and whether there is a certain stage in the customer lifecycle when support is usually needed.
Answering these questions helps the company better understand the needs of their mobile customers.
Angel noted that the answers to these questions should be combined with analytics and past customer data to help the company better understand the needs of its mobile customers. One solution that helps utilize past customer data is a CX dashboard such as Angel's Caller First Analytics solution.
Next, businesses will want to create a mobile CX strategy around these insights.
Mobile CX should not be a carbon copy of CX strategy from other channels, however. It requires additional capabilities. Angel outlined a few that companies might consider: branded mobile apps, interactive self-service tools, location-based capabilities, text message support, proactive mobile alerts, and interactions tailored to customers so as not to invade their personal device.
"Regardless of the specific features, a mobile CX is only as successful as its availability," Angel wrote in a blog post earlier this year. "If customers experience any downtime with a company's mobile features, they will lose trust in the channel and the business risks losing that customer for good."
Once a mobile CX strategy is developed, customer care leaders still need to implement. They should look to integrating mobile CX with interactive voice response (IVR), according to Angel. IVR helps alleviate staffing problems normally, but in a mobile CX environment it also can aid live customer reps by providing them business intelligence and giving them a way to interact with the mobile customer using the graphics, photos and texts mobile users are able to submit on a mobile platform.
"Imagine the possibilities that can result from combining a powerful IVR with all the benefits of mobility," wrote Angel. Pointing to its Caller FirstSM approach, it says the marriage of IVR with mobile CX "combines customer data with business intelligence to enable you to know who your customers are, cater to their preferences, anticipate their needs, respect their time and enable you to make real-time changes to fast changing business requirements."
Mobility is here to stay, so companies need to make sure they have a mobile CX channel in place and properly defined.
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Probe into Nuclear Fuel Services incident expanded
ERWIN, Tenn. — The Nuclear Regulatory Commission today said it is expanding its investigation into an incident at the Nuclear Fuel Services complex here on Oct. 13.
The NRC has formed an Augmented Inspection Team to further review the situation where unexpected levels of heat and nitrogen compound gas fumes were created as scrap metal containing low levels of uranium from Department of Energy projects were being dissolved. The reaction caused concern that key equipment used in converting radioactive material into nuclear fuel could have been damaged.
The NRC explained that an Augmented Inspection Team is formed to review significant incidents at NRC-licensed facilities and the team will expand the investigation being done by an NRC inspection team sent to the site earlier this week.
"This particular incident did not involve nuclear criticality issues, but it shows the need for NFS management to improve some aspects of their operational decision-making processes," NRC Region II Administrator Luis Reyes said in a statement. "Upgrading our inspection to an AIT underscores our commitment to evaluate these issues thoroughly and ensure they are being properly addressed."
The NRC said it will meet with Nuclear Fuel Services when the investigation is completed to discuss the AI Team's findings. The meeting will be open to the public. A report will be issued 30 days after the probe is complete.
The Nuclear Fuel Services incident occurred as the company works with NRC officials to renew the company's license to handle nuclear materials.
More details as they develop online and in Friday's News Sentinel.
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Results 1 to 6 of 6
- 11-17-2012, 07:53 PM Thread Author #1
Two issues - Battery indicator and Gallery running high overnight?
Hey all,
First off, I'd like to say that I absolutely LOVE my S3! I bought it about a week ago, and haven't put it down since. However, I've run into a couple of issues which I hope someone may be able to help me out with:
1) As of yesterday, I noticed that my battery indicator does not match the percentage of the battery life itself. I did a restart, pulled the battery out for about 10 minutes, powered it on, and still the same. Odd much:
2) After I charge my phone to 100% each night, I take it off the charger, turn SYNC and MOBILE DATA off, and only leave Wifi on. That's no big deal right? Anyways, I wake up the next day to find this:
I did further research, and discovered that Picasa was the typical reason. Cool...but I disabled Picasa the same day I bought the phone (the snapshot above is from this morning). Could Dropbox be responsible? -
- 11-19-2012, 12:02 AM Thread Author #3
Re: Two issues - Battery indicator and Gallery running high overnight?
Have you rebooted? Take a deep dive into every google app you have and check settings. I was amazed at 1)how much is going on behind the scenes in these apps and 2) how much control the settings give you. i e google maps logs everywhere you go in a huge list and tries to share this with your friends when they look you up via Google. Who knew...
S3 on Sprint - 16gb pebble blue + 64 - 11-20-2012, 03:35 AM #5
Re: Two issues - Battery indicator and Gallery running high overnight?
For the gallery thing and picasa go to gallery in the apps and clear data. That's how I fixed my gallery taking up battery problem
Sent from my MZ604 using Android Central ForumsPhone: LG G2
Android Version: 4.2.2
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Htc Evo 3d
Samsung Galaxy S3 -
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CPAP reduces GERD by half Gastroesophageal reflux disorder or GERD may be improved with the use of CPAP. Doctors at Duke University Me More >
Cardiovascular Effects of Continuous Positive Airway Pressure in Patients with Heart Failure and OSA Twenty-four patients with depressed left ventricular ejection fraction (45 percent or less) and obstructive More >
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Effect of Nasal Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients with OSA There is increasing evidence that obstructive sleep apnea (OSA) is an independent risk factor for arterial h More >
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text: Video: Skating legend Barbara Ann Scott remembered Add to ... CP Video Published Monday, Oct. 01 2012, 6:15 PM EDT Last updated Monday, Oct. 01 2012, 6:34 PM EDT Olympic figure skater Barbara Ann Scott is being fondly remembered at the Minto Skating Club in Ottawa. Club members say Scott, who passed away Sunday at the age of 84, never forgot the rink where she got her start. Watch More Video: Brad Pitt puts on his producer hat for Sundance Video: Ballet for urban spaces How this ad campaign reinvigorated Canadian basketball fans New U.S. visa rules cut red tape with China The hidden 'culture clash' stifling innovation Filipino artists paint murals of typhoon devastation to mark one year anniversary Three trick-or-treating teenage girls killed in California hit-and-run Hotels: Manitoba's child-welfare placement of last resort Vibrating 'SmartCane' device helps blind people avoid obstacles Bumgarner shuts out Royals, Giants lead World Series Cardinals outfielder Taveras dies in car accident PotashCorp CEO positive on demand, despite a miss in earnings Bif Naked talks about living on $3 a day for food Consultants should park their attitudes at the border No medical staff to West Africa without evacuation plan: Ambrose Tugboat tows ailing Russian cargo ship At least 12 people killed in avalanche, snow storm in Nepal Stuart Percy praised by Leafs for strong early performance Video: Pumpkin growers aim to squash record Malala: 'More powerful' with Nobel Peace win Comments AA More Related to this Story watch Video: Remembering Barbara Ann Scott watch Video: Immigrants embrace ice skating in Winnipeg watch Video: Chan headlines figure skating nationals


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French Drugstore Beauty Products
10 Must-Have French Beauty Brands You Can Snag Stateside
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10 Must-Have French Beauty Brands You Can Snag Stateside
It used to be that a trip to Paris meant bringing along an empty suitcase to house all the drugstore beauty buys you'd stock up on. Fortunately, the days of product smuggling are just about over. Most of the products that travelers pine over are available stateside, thanks to that handy thing called online shopping. In honor of Bastille Day, click through to see the top 10 French brands you'll fall in love with . . . and keep your passport at home.
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The French pharmacy is my absolute favorite place to shop! There are so many awesome products. Here are some of my reviews and some of
my go-to French pharmacy beauty buys: http://thesweetseed.com/2014/1...
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- How makeup artists decide celebrity red carpet looks — Byrdie
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- An inside look at being a salesperson at a makeup store — Racked
- Rosie Huntington-Whiteley dishes on her new fragrance — Grazia Daily
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I'm now working on PyQt project and sometimes I need stop execution and debug some variables.
In past, I was a Ruby on Rails developer and my solution was always pry gem.
In Python and in special for PyQt application I found this solution after read some answers on ...
read more


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What I want to do
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My Role: Donor & Promoted Safe Sun Awareness.
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Metal forks are replaced by plastic
In the hall
Counseling Secretary talks about her day
Laurissa Marcotte, Staff Reporter
February 17, 2012
Filed under Movie/Book Reviews
We all forget things from time to time—our keys, our phone, our homework. But what would you do if you forgot an entire section of your life? The Vow is a classic romance about a woman, Paige, and her journey to... Read more »


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Gardening experts at DIY Network share top 10 secrets for making a food plot thrive.
By Marie HoferMore in Outdoors
DK - Vegetable Gardening © 2007 Dorling Kindersley Limited
Vegetables are divided into two categories: warm-season and cool-season crops. Gardeners in cooler climates with short summers may find better luck growing warm-season vegetables (such as tomatoes, peppers and squash) in a greenhouse to extend the growing season. While nearly all vegetables prefer full sun (6 or more hours daily), some cool-season crops, such as lettuce and radishes, can get by with 4 to 5.
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made from a vogue pattern. Easy to make, I've already got a Tshirt like that and finally decided to try the dress version. Material is a very smooth and comfy jersey, very pleasant to wear.
Dec 2, 2012, 02.06 PMby Mary Athey
This is lovely.on you. I love the gathers and the fabrics fab x
Dec 3, 2012, 09.01 AMby chula123
thank you so much ! xx
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I have a problem, I bottled my cider 11 days ago now my bottles are ferm to squeeze I put one in the fridge overnight as I am keen to try, when I grabbed the bottle from the fridge the next day it had appeared to have lost its gas as the bottle was no longer firm and bear was flat, can anyone advise me on what maybe the problem is
need details; was this a bear rug, or an actual 3D bear?
Not sure what rug or 3d is, yes I'm a newbie, it came in can and a satchel of brew enhancer followed the directions it fermented on the higher end of the recommended temp range finished fermenting in about 10 days started at 1.038 finished at 1.003 left for a couple of days before bottling added carb drops, from memory its supposed to be stored for 5 weeks but as I was keen to taste it I put a bottle in the fridge after 10 days the bottle was under pressure so thought that may haves carbed up but when I took it out of the fridge the next day it was deflated I could squeeze the bottle easily as though it had decarbed and opens it and yes it was flat cider only a few bubbles tasted like white wine
11 days may not have been enough, depends on the volume of yeast in the bottles and temperature. You can move the bottles to a warmer location to speed up the process. My graff took 3 weeks to get to the carb level I anticipated but it was 65 degrees in the cupboard where I was keeping it.
I used to have a six-pack, but now I have a keg.


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Kashmiri Shiite Muslims step on a US flag painted on the street... News Photo 156745317American Flag,Ashura,Century,Day 4,Grandson,Holding,Horizontal,India,Iraq,Jammu and Kashmir,Killing,Males,Memories,Muhammad,Painting,Parade,Religion,Seventh,Shi'ite Islam,Srinagar,Steps,StreetPhotographer TAUSEEF MUSTAFACollection: AFP 2012 AFPKashmiri Shiite Muslims step on a US flag painted on the street during a religious procession held on the fourth day of Ashura, which remembers the slaying of the Prophet Mohammed's grandson in southern Iraq in the seventh century, in Srinagar on November 20,2012. During the Shiite Muslim holy month of Muharram, large processions are formed and the devotees parade the streets holding banners and carrying models of the mausoleum of Hazrat Imam Hussain and his people, who fell at Karbala. Shias show their grief and sorrow by inflicting wounds on their own bodies with sharp metal tied to chain to depict the sufferings of the martyrs. AFP PHOTO/ Tauseef MUSTAFA (Photo credit should read TAUSEEF MUSTAFA/AFP/Getty Images)


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Aries Star CTR Ring (4.5)
by One Moment in Time
$9.95 List Price
Ships in 2 to 3 business days
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love it!!!
by Customer - reviewed on January 15, 2011
i bought this ring to dedicate myself more and i love it ! your getting a good ring for a good price. i wash my hands with the ring on and it has yet to leave a green ring around my finger it is extremely comfortable .


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You can now move and hear 3D sound all around you in Oculus' latest virtual reality prototype, and the demo is astounding.
Has Microsoft suddenly pushed us into the age of "Star Trek" and "Minority Report"? For those confused about what's actually going on with the company's new head-mounted gadget, here's the rundown.
Virtual reality is still a virtual reality; until certain aspects evolve, don't expect perfection any time soon. This was never more clear than at this year's CES show in Vegas.
With the major press events behind us and the doors officially open, CES has shifted into a different mode. Here are the highlights from Day 2 of the world's biggest tech show.
The crowds have hit the ground running at CES in search of the novel and interesting technology that wasn't covered on Press Day. Here's everything you need to know from Day 1.
Jack Gangwish says that as he was posing with a racccoon for a selfie, the animal bit him. He says he accidentally killed it with a crescent wrench.
Is a Bluetooth speaker that's always listening creepy? And how much would you pay for Office mobile apps? We'll address those questions and more in this look back at the week in tech.
The company is helping out with health education and emergency voice and data services, and giving its users an easy way to make donations.
"Crescent Bay" prototype promises a better display and new sensors to track player's movements while using the device.
We're right around the corner from a consumer version of Oculus Rift, and the improvements made in the newest version unveiled this past weekend? They're something to get excited about, at least in our opinion.


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Arizona Wildcats
Woman arrested after famous Austin mural defaced
AUSTIN, Texas (AP) - A woman has been arrested after police saw her defacing a well-known Austin mural painted by Texas singer-songwriter Daniel Johnston.
According to an arrest affidavit, 32-year-old Rebecca Guest was arrested Christmas Eve and charged with a Class A misdemeanor for the act of graffiti. An obscene word was spray-painted several times on the mural, which depicts a frog-like creature saying "Hi, How Are You."
Guest told police that she believed the mural was offensive and meant to personally insult her.
She was out of custody by Wednesday afternoon. An Austin phone number could not be found.
Johnston painted the mural in 1993 on the exterior wall of what was then a record store. The image was printed on a T-shirt, which Nirvana frontman Kurt Cobain once wore.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
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- Don MacLean, Pac-12 Networks basketball analystDon discusses the big UA basketball game against Utah coming up this weekend.
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15" Pajama Teddy Bear
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