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- Conservatives join New Hampshire rally in support of campaign finance reform
- 11 public housing residents complete job readiness training
- Youth health care enrollment event at NIU Rockford Jan. 29
- More than 50 employers at Jan. 29 job fair
- School district's credit rating remains solid
- State Police seize LSD, cannabis, U.S. currency in I-80 arrest
- Park District names employee, team of the year
- A closer look at fracking for natural gas
- Susan Johnson, copy editor, moves on after 21 years
- Guest Column: Clean Water Act: Supporters of clean water must make their voices heard
Guest Column: PBS, NPR funding under attack
From 170 million AmericansTM For Public Broadcasting website, http://capwiz.com
Please be very concerned about all of the recent attempts and various pieces of legislation (H.R. 68, H.R. 69, H.R. 235, H.R. 408 and S. 178) that seek to eliminate funding for public broadcasting. Urge your U.S. senators and congressmen to oppose these pieces of legislation and any further efforts to cut or eliminate funding for this essential community resource.
Local public television and radio stations are critically important to the 170 million Americans who access public broadcasting services each month. The small cost per person—annually $1.35 per citizen—is far outweighed by the benefits derived from having a strong public broadcasting system to address local community needs and provide services unmet elsewhere.
Public broadcasting is one of the most successful public/private partnerships in America, with $6 in local support matching every $1 invested by the federal government. Cutting off federal dollars would have a cascade effect that would be catastrophic to the millions of people who use public broadcasting every day.
More than 1,000 local public television and radio stations exist in America, representing some of the last locally-owned, locally-staffed and locally-programmed media outlets in this country. These stations are in every community across the country and employ some 21,000 people.
Public broadcasting is an essential service to the American people—not a "luxury," as some contend. Without public broadcasting, communities would lose access to the safe haven of children's non-commercial educational content, the in-depth news and public affairs programming, access to the world of arts and cultural locally, nationally and internationally, and the local voice that weaves the diverse perspectives of American communities together.
In addition to the unparalleled programming offered by local public broadcasters, local stations are maximizing digital technology and their universal reach to provide critical resources to local communities. For example, public radio stations provide reading services for the blind, public television stations partner with state and local departments of education to provide teachers with online educational resources aligned with state standards, and both television and radio stations provide critical and targeted emergency communications in the wake of a disaster. Without federal funding, these critical resources will disappear, disenfranchising millions of Americans who depend on these services.
The minimal federal investment in public broadcasting stations ensures free and universal access to an array of high-quality, educational, non-commercial content and services. These services are too valuable to lose.
We are sure, as a constituent who highly values the programming and services of local public broadcasters, urge your U.S. senators and congressmen to oppose any efforts to cut funding for public broadcasting.
For a copy of this petition to sign, go to http://capwiz.com/170ma/issues/alert/?alertid=23448501.
From the Feb. 16-21, 2011, issue


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The Horizon Accords
View Single Post
Empire Veteran
Join Date: Jul 2012
Posts: 5,696
# 27
Originally Posted by
mimey, i think deleting or not using anything in the game is walking a path that will keep people away from agreeing on anything.
you go ahead, and use your snb doffs. i aim not to take anything away from anyone. but as i've stated in the accords, some one will notice you stripping their buffs.... and that will put your own future competitive game play at risk.
i would suggest being open about what you are running. be transparent. only 1v1 others with snb doffs, maybe take them completely off when you face an unexperienced pug. or, keep them on there when you notice a few good pilots on the other end. you will most likely only have to remember a few dozen names.
i, myself have attack pattern doffs, giving me 100% uptime on attack patterns....pretty sick right. and im not giving them up. they are great, and ive adapted my playstyle to them.
True indeed, but that was more a rhetorical question than anything else. It was more meant for you to ask it to yourself if you really would do it.
I said in my previous post, I wasn't going to use them in the first place...well, not use them in PvP that is. I have more important space DOFFs that I use on the character I bought them on. So there's no need to worry or fuss about that from me.
Attack Pattern DOFFs, eh? I know how good they can be, to always have Omega 3 up, along with the others. But it's easy to give up one thing, but not another. You say they are part of your play style, and that's perfectly ok. I'm just bringing up the point that 'that's not ok, but what I do is ok', or that's how it seems to look to me.
Now don't misunderstand all this, I do like this whole idea you have here Horizon, I'm just keeping a seperate, 'outsiders' view on this whole thing.
A mime is a terrible thing to waste


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Richard's sister Charlotte has been searching for her brother since 1964. She has had some professional even looking for him , with no luck. Richard was b. Bronx, new york, march 17, 1946, parents Anna Louise Bowman Schmitt(schmidt), father Alois Ambros Schmitt(schmidt). Richard's other siblings are 2 sisters., Mary and Rose. Richard went in the Army at Ft. Leonardwood MO. 1964 and has not been seen since. He called his sister Charlotte and said he would be home in Nov. of 1964, never came home. Description, Blond hair, hazel eyes, about 6 ft. tall, front tooth was chipped in 1964. thank you for any help betty firstname.lastname@example.com Notify Administrator about this message?
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text: Design for, a candy box US D130500 S Abstract available in Claims available in Description (OCR text may contain errors) ' Nov. 25, 1941. E. HUCH I Des. 130,500 CA B Patented Nov. 25, 1941 D 130,500 UNITED STATES PATENT OFFICE DESIGN FOR A CANDY BOX Emma Huch, New York, N. Y. . Application August 2, 1941, Serial No. 102,652 Term of patent 14 years To all whom it may concern: Fig. 1 is a perspective View of a candy box with Be it known that I, Emma, Huch, a citizen of the cover flap open, showing my new design. the United States and resident of New York city, Fig. 2 is a front elevational view of the same. in the county of New York and State of New Fig. 3 is a. top plan View of the same, showing York, have invented a new, original, and ornathe cover flap closed. mental Design for 2. Candy Box, of which the I claim: following is a specification, reference being had The ornamental design for a candy box, as to the accompanying drawing, forming a part shown. thereof. EMMA HUCI-I. In the drawing: Rotate |


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Publications (51)206.05 Total impact
Article: Location of Novel Benzanthrone Dyes in Model Membranes as Revealed by Resonance Energy Transfer.
[Show abstract] [Hide abstract]
ABSTRACT: Förster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine (AV-PC) as a donor and newly synthesized benzanthrones (referred to here as A8, A6, AM12, AM15 and AM18) as acceptors has been examined to gain insight into molecular level details of the interactions between benzanthrone dyes and model lipid membranes composed of zwitterionic lipid phosphatidylcholine and its mixtures with anionic lipids cardiolipin (CL) and phosphatidylglycerol (PG). FRET data were quantitatively analyzed in terms of the model of energy transfer in two-dimensional systems taking into account the distance dependence of orientation factor. Evidence for A8 location in phospholipid headgroup region has been obtained. Inclusion of CL and PG into PC bilayer has been found to induce substantial relocation of A6, AM12, AM15 and AM18 from hydrophobic membrane core to lipid-water interface.Journal of Fluorescence 03/2014; · 1.79 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Phosphatidycholines (PC) with two saturated acyl chains (e.g. dipalmitoyl) mimic natural sphingomyelin (SM) by promoting raft formation in model membranes. However, sphingoid-based lipids, such as SM, rather than saturated-chain PCs have been implicated as key components of lipid rafts in biomembranes. These observations raise questions about the physical packing properties of the phase states that can be formed by these two major plasma membrane lipids with identical phosphocholine headgroups. To investigate, we developed a monolayer platform capable of monitoring changes in surface fluorescence by acquiring multiple spectra during measurement of a lipid force-area isotherm. We relied on the concentration-dependent emission changes of 4,4 difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-labeled PC to detect nano scale alterations in lipid packing and phase state induced by monolayer lateral compression. The BODIPY-PC probe contained an indacene ring with four symmetrically-located methyl (Me) substituents to enhance localization to the lipid hydrocarbon region. Surface fluorescence spectra indicated changes in miscibility even when force-area isotherms showed no deviation from ideal mixing behavior in the surface pressure versus cross-sectional molecular area response. We detected slightly better mixing of Me4-BODIPY-8-PC with the fluid-like, liquid expanded phase of 1 palmitoyl-2-oleoyl-PC compared to N-oleoyl-SM. Remarkably, in the gel-like, liquid condensed phase, Me4-BODIPY-8-PC mixed better with N-palmitoyl-SM than dipalmitoyl-PC, suggesting naturally-abundant SMs with saturated acyl chains form gel-like lipid phase(s) with enhanced ability to accommodate deeply embedded components compared to dipalmitoyl-PC gel phase. The findings reveal a fundamental difference in the lateral packing properties of SM and PC that occurs even when their acyl chains match.Langmuir 02/2014; · 4.38 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The accelerated cell death 11 (acd11) mutant of Arabidopsis provides a genetic model for studying immune response activation and localized cellular suicide that halt pathogen spread during infection in plants. Here, we elucidate ACD11 structure and function and show that acd11 disruption dramatically alters the in vivo balance of sphingolipid mediators that regulate eukaryotic-programmed cell death. In acd11 mutants, normally low ceramide-1-phosphate (C1P) levels become elevated, but the relatively abundant cell death inducer phytoceramide rises acutely. ACD11 exhibits selective intermembrane transfer of C1P and phyto-C1P. Crystal structures establish C1P binding via a surface-localized, phosphate headgroup recognition center connected to an interior hydrophobic pocket that adaptively ensheaths lipid chains via a cleft-like gating mechanism. Point mutation mapping confirms functional involvement of binding site residues. A π helix (π bulge) near the lipid binding cleft distinguishes apo-ACD11 from other GLTP folds. The global two-layer, α-helically dominated, "sandwich" topology displaying C1P-selective binding identifies ACD11 as the plant prototype of a GLTP fold subfamily.Cell Reports 01/2014; · 7.21 Impact Factor -
Article: Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids.
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ABSTRACT: Phosphorylated sphingolipids ceramide-1-phosphate (C1P) and sphingosine-1-phosphate (S1P) have emerged as key regulators of cell growth, survival, migration and inflammation. C1P produced by ceramide kinase is an activator of group IVA cytosolic phospholipase A2α (cPLA2α), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid production, which contributes to disease pathogenesis in asthma or airway hyper-responsiveness, cancer, atherosclerosis and thrombosis. To modulate eicosanoid action and avoid the damaging effects of chronic inflammation, cells require efficient targeting, trafficking and presentation of C1P to specific cellular sites. Vesicular trafficking is likely but non-vesicular mechanisms for C1P sensing, transfer and presentation remain unexplored. Moreover, the molecular basis for selective recognition and binding among signalling lipids with phosphate headgroups, namely C1P, phosphatidic acid or their lyso-derivatives, remains unclear. Here, a ubiquitously expressed lipid transfer protein, human GLTPD1, named here CPTP, is shown to specifically transfer C1P between membranes. Crystal structures establish C1P binding through a novel surface-localized, phosphate headgroup recognition centre connected to an interior hydrophobic pocket that adaptively expands to ensheath differing-length lipid chains using a cleft-like gating mechanism. The two-layer, α-helically-dominated 'sandwich' topology identifies CPTP as the prototype for a new glycolipid transfer protein fold subfamily. CPTP resides in the cell cytosol but associates with the trans-Golgi network, nucleus and plasma membrane. RNA interference-induced CPTP depletion elevates C1P steady-state levels and alters Golgi cisternae stack morphology. The resulting C1P decrease in plasma membranes and increase in the Golgi complex stimulates cPLA2α release of arachidonic acid, triggering pro-inflammatory eicosanoid generation.Nature 07/2013; · 42.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Human glycolipid transfer protein (hsGLTP) forms the prototypical GLTP fold and is characterized by a broad transfer selectivity for glycosphingolipids (GSLs). The GLTP mutation D48V near the `portal entrance' of the glycolipid binding site has recently been shown to enhance selectivity for sulfatides (SFs) containing a long acyl chain. Here, nine novel crystal structures of hsGLTP and the SF-selective mutant complexed with short-acyl-chain monoSF and diSF in different crystal forms are reported in order to elucidate the potential functional roles of lipid-mediated homodimerization. In all crystal forms, the hsGLTP-SF complexes displayed homodimeric structures supported by similarly organized intermolecular interactions. The dimerization interface always involved the lipid sphingosine chain, the protein C-terminus (C-end) and α-helices 6 and 2, but the D48V mutant displayed a `locked' dimer conformation compared with the hinge-like flexibility of wild-type dimers. Differences in contact angles, areas and residues at the dimer interfaces in the `flexible' and `locked' dimers revealed a potentially important role of the dimeric structure in the C-end conformation of hsGLTP and in the precise positioning of the key residue of the glycolipid recognition centre, His140. ΔY207 and ΔC-end deletion mutants, in which the C-end is shifted or truncated, showed an almost complete loss of transfer activity. The new structural insights suggest that ligand-dependent reversible dimerization plays a role in the function of human GLTP.Acta Crystallographica Section D Biological Crystallography 04/2013; 69(Pt 4):603-16. · 7.23 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Among amphitropic proteins, human glycolipid transfer protein (GLTP) forms a structurally-unique fold that translocates on/off membranes to specifically transfer glycolipids. Phosphatidylcholine (PC) bilayers with curvature-induced packing stress stimulate much faster glycolipid intervesicular transfer than nonstressed PC bilayers raising questions about planar, cytosol-facing biomembranes being viable sites for GLTP interaction. Herein, GLTP-mediated desorption kinetics of fluorescent glycolipid (tetramethyl-BODIPY-label) from lipid monolayers are assessed using a novel, microfluidics-based surface balance that monitors lipid lateral packing while simultaneously acquiring surface fluorescence data. At biomembrane-like packing (30-35 mN/m), GLTP uptake of BODIPY-glycolipid from 1 palmitoyl-2-oleoyl-PC monolayers was nearly nonexistent but could be induced by reducing surface pressure to mirror packing in curvature-stressed bilayers. In contrast, 1-palmitoyl-2-oleoyl-phosphatidylethanolamine (POPE) matrices supported robust BODIPY-glycolipid uptake by GLTP at both high and low surface pressures. Unexpectedly, negatively-charged, cytosol-facing lipids, i.e. phosphatidic acid and phosphatidylserine, also supported BODIPY-glycolipid uptake by GLTP at high surface pressure. Remarkably, including both POPA (5 mole%) and POPE (15 mole%) in POPC synergistically activated GLTP at high surface pressure. Our study shows that matrix lipid headgroup composition, rather than molecular packing per se, is a key regulator of GLTP-fold function while demonstrating the novel capabilities of the microfluidics-based film balance for investigating protein-membrane interfacial interactions.The Journal of Lipid Research 01/2013; · 4.73 Impact Factor - Biophysical Journal 01/2013; 104(2):593-. · 3.83 Impact Factor
Article: Focusing the Glycolipid Specificity of Human Glycolipid Transfer Protein by Designer Mutation
Biophysical Journal 01/2013; 104(2):593-. · 3.83 Impact Factor -
Dataset: 103b J.Biol.Chem. 2010
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ABSTRACT: Phosphoinositol 4-phosphate adaptor protein-2 (FAPP2) plays a key role in glycosphingolipid (GSL) production using its C-terminal domain to transport newly synthesized glucosylceramide away from the cytosol-facing glucosylceramide synthase in the cis-Golgi for further anabolic processing. Structural homology modeling against human glycolipid transfer protein (GLTP) predicts a GLTP-fold for FAPP2 C-terminal domain, but no experimental support exists to warrant inclusion in the GLTP superfamily. Here, the biophysical properties and glycolipid transfer specificity of FAPP2-C-terminal domain have been characterized and compared with other established GLTP-folds. Experimental evidence for a GLTP-fold includes: i) Far-UV circular dichroism (CD) showing secondary structure with high alpha-helix content and a low thermally-induced unfolding transition (~41°C); ii) Near-UV-CD indicating only subtle tertiary conformational change before/after interaction with membranes containing/lacking glycolipid; iii) Red-shifted tryptophan (Trp) emission wavelength maximum (λ(max) ~352nm) for apo-FAPP2-C-terminal domain consistent with surface exposed intrinsic Trp residues; iv) 'Signature' GLTP-fold Trp fluorescence response, i.e., intensity decrease (~30%) accompanied by strongly blue-shifted λ(max) (~14nm) upon interaction with membranes containing glycolipid, supporting direct involvement of Trp in glycolipid binding and enabling estimation of partitioning affinities. A structurally-based preference for other simple uncharged GSLs, in addition to glucosylceramide, makes human FAPP2-GLTP more similar to fungal HET-C2 than to plant AtGLTP1 (glucosylceramide-specific) or to broadly GSL-selective human GLTP. These findings along with the distinct mRNA exon/intron organizations originating from single-copy genes on separate human chromosomes suggest adaptive evolutionary divergence by these two GLTP-folds.Biochimica et Biophysica Acta 11/2012; 1831(2):417. · 4.66 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Protein polymerization into ordered fibrillar structures (amyloid fibrils) is currently associated with a range of pathological conditions. Recent studies clearly indicate that amyloid cytotoxicity is provoked by a continuum of cross-β-sheet aggregates including mature fibrils. In view of the possible diversity of cytotoxicity mechanisms, the present study addressed the question of whether protein conversion into amyloid fibrils can modify its competitive membrane adsorption behavior. Using a combination of resonance energy transfer, dynamic light scattering and fluorescence quenching techniques, the competitive binding of either monomeric or polymerized lysozyme, and cytochrome c to the model lipid membranes composed of phosphatidylcholine mixtures with varying proportions of phosphatidylglycerol, phosphatidylserine or cardiolipin has been studied. The ability of fibrillar lysozyme to induce dissociation of cytochrome c from the membrane binding sites proved to be markedly stronger than that of its monomeric counterpart, with desorption process displaying cooperativity features upon increasing the charge of lipid bilayer. The decreased efficiency of tryptophan fluorescence quenching by acrylamide and short-wavelength shift of emission maximum observed upon membrane binding of lysozyme fibrils were rationalized in terms of fluorophore transfer into interfacial bilayer region. It is hypothesized that electrostatic interactions play predominant role in determining the lipid-associating and competitive abilities of fibrillar lysozyme.Chemistry and Physics of Lipids 10/2012; · 2.59 Impact Factor - Biophysical Journal 01/2012; 102(3):495-. · 3.83 Impact Factor
- Biophysical Journal 01/2012; 102(3):495-. · 3.83 Impact Factor
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ABSTRACT: Human glycolipid transfer protein (GLTP) fold represents a novel structural motif for lipid binding/transfer and reversible membrane translocation. GLTPs transfer glycosphingolipids (GSLs) that are key regulators of cell growth, division, surface adhesion, and neurodevelopment. Herein, we report structure-guided engineering of the lipid binding features of GLTP. New crystal structures of wild-type GLTP and two mutants (D48V and A47D‖D48V), each containing bound N-nervonoyl-sulfatide, reveal the molecular basis for selective anchoring of sulfatide (3-O-sulfo-galactosylceramide) by D48V-GLTP. Directed point mutations of "portal entrance" residues, A47 and D48, reversibly regulate sphingosine access to the hydrophobic pocket via a mechanism that could involve homodimerization. "Door-opening" conformational changes by phenylalanines within the hydrophobic pocket are revealed during lipid encapsulation by new crystal structures of bona fide apo-GLTP and GLTP complexed with N-oleoyl-glucosylceramide. The development of "engineered GLTPs" with enhanced specificity for select GSLs provides a potential new therapeutic approach for targeting GSL-mediated pathologies.Structure 11/2011; 19(11):1644-54. · 6.79 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The glycolipid transfer protein (GLTP) superfamily is defined by the human GLTP fold that represents a novel motif for lipid binding and transfer and for reversible interaction with membranes, i.e., peripheral amphitropic proteins. Despite limited sequence homology with human GLTP, we recently showed that HET-C2 GLTP of Podospora anserina is organized conformationally as a GLTP fold. Currently, insights into the folding stability and conformational states that regulate GLTP fold activity are almost nonexistent. To gain such insights into the disulfide-less GLTP fold, we investigated the effect of a change in pH on the fungal HET-C2 GLTP fold by taking advantage of its two tryptophans and four tyrosines (compared to three tryptophans and 10 tyrosines in human GLTP). pH-induced conformational alterations were determined by changes in (i) intrinsic tryptophan fluorescence (intensity, emission wavelength maximum, and anisotropy), (ii) circular dichroism over the near-UV and far-UV ranges, including thermal stability profiles of the derivatized molar ellipticity at 222 nm, (iii) fluorescence properties of 1-anilinonaphthalene-8-sulfonic acid, and (iv) glycolipid intermembrane transfer activity monitored by Förster resonance energy transfer. Analyses of our recently determined crystallographic structure of HET-C2 (1.9 Å) allowed identification of side chain electrostatic interactions that contribute to HET-C2 GLTP fold stability and can be altered by a change in pH. Side chain interactions include numerous salt bridges and interchain cation-π interactions, but not intramolecular disulfide bridges. Histidine residues are especially important for stabilizing the local positioning of the two tryptophan residues and the conformation of adjacent chains. Induction of a low-pH-induced, molten globule-like state inhibited glycolipid intermembrane transfer by the HET-C2 GLTP fold.Biochemistry 06/2011; 50(23):5163-71. · 3.38 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Total internal reflection fluorescence microscopy (TIRFM) has been utilized to explore the effect of cationic protein lysozyme (Lz) on the morphology of solid-supported lipid bilayers (SLBs) comprised of zwitterionic lipid phosphatidylcholine (PC) and its mixture with anionic lipid cardiolipin (CL). Kinetic TIRFM imaging of different systems revealed subtle interplay between lipid lateral segregation accompanied by exchange of neutral and acidic lipids in the protein-lipid interaction zone, and the formation of lipid multilayer stacks. The switch between these states was shown to be controlled by CL content. In weakly charged SLBs containing 5 mol% CL, assembling of CL molecules into planar domains upon Lz adsorption has been observed while at higher content of anionic lipid (25 mol%) in-plane domains tend to transform into multilayer stacks, thereby ensuring the most thermodynamically-favorable membrane conformation.Colloids and surfaces B: Biointerfaces 10/2010; 80(2):219-26. · 4.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Human glycolipid transfer protein (GLTP) serves as the GLTP-fold prototype, a novel, to our knowledge, peripheral amphitropic fold and structurally unique lipid binding motif that defines the GLTP superfamily. Despite conservation of all three intrinsic Trps in vertebrate GLTPs, the Trp functional role(s) remains unclear. Herein, the issue is addressed using circular dichroism and fluorescence spectroscopy along with an atypical Trp point mutation strategy. Far-ultraviolet and near-ultraviolet circular dichroism spectroscopic analyses showed that W96F-W142Y-GLTP and W96Y-GLTP retain their native conformation and stability, whereas W85Y-W96F-GLTP is slightly altered, in agreement with relative glycolipid transfer activities of >90%, ∼85%, and ∼45%, respectively. In silico three-dimensional modeling and acrylamide quenching of Trp fluorescence supported a nativelike folding conformation. With the Trp⁹⁶-less mutants, changes in emission intensity, wavelength maximum, lifetime, and time-resolved anisotropy decay induced by phosphoglyceride membranes lacking or containing glycolipid and by excitation at different wavelengths along the absorption-spectrum red edge indicated differing functions for W142 and W85. The data suggest that W142 acts as a shallow-penetration anchor during docking with membrane interfaces, whereas the buried W85 indole helps maintain proper folding and possibly regulates membrane-induced transitioning to a glycolipid-acquiring conformation. The findings illustrate remarkable versatility for Trp, providing three distinct intramolecular functions in the novel amphitropic GLTP fold.Biophysical Journal 10/2010; 99(8):2626-35. · 3.83 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Resonance energy transfer (RET) from anthrylvinyl-labeled phosphatidylcholine (AV-PC) or cardiolipin (AV-CL) to cytochrome c (cyt c) heme moiety was employed to assess the molecular-level details of protein interactions with lipid bilayers composed of PC with 2.5 (CL2.5), 5 (CL5), 10 (CL10), or 20 (CL20) mol % CL under conditions of varying ionic strength and lipid/protein molar ratio. Monte Carlo analysis of multiple data sets revealed a subtle interplay between 1), exchange of the neutral and acidic lipid in the protein-lipid interaction zone; 2), CL transition into the extended conformation; and 3), formation of the hexagonal phase. The switch between these states was found to be controlled by CL content and salt concentration. At ionic strengths ≥ 40 mM, lipid bilayers with CL fraction not exceeding 5 mol % exhibited the tendency to transform from lamellar to hexagonal phase upon cyt c adsorption, whereas at higher contents of CL, transition into the extended conformation seems to become thermodynamically favorable. At lower ionic strengths, deviations from homogeneous lipid distributions were observed only for model membranes containing 2.5 mol % CL, suggesting the existence of a certain surface potential critical for assembly of lipid lateral domains in protein-lipid systems that may subsequently undergo morphological transformations depending on ambient conditions. These characteristics of cyt c-CL interaction are of great interest, not only from the viewpoint of regulating cyt c electron transfer and apoptotic propensities, but also to elucidate the general mechanisms by which membrane functional activities can be modulated by protein-lipid interactions.Biophysical Journal 09/2010; 99(6):1754-63. · 3.83 Impact Factor -
Article: The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment.
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ABSTRACT: The in vitro activity of the ceramide transporter, CERT has been studied using a fluorescence assay. CERT is responsible for the in vivo non-vesicular trafficking of ceramide between the endoplasmic reticulum and Golgi. In this study we have examined how the membrane environment surrounding the ceramide substrate, the membrane packing density and the membrane charge, are affecting the ceramide transfer activity. To examine this we have used an anthrylvinyl-labeled ceramide analogue. We found that if ceramide is in a tightly packed environment such as in sphingomyelin or dipalmitoylphosphatidylcholine containing membranes, the CERT transfer activity is markedly reduced. Ceramide in fluid membranes on the other hand are available for CERT mediated transfer. CERT also favors membranes that contain phosphatidylinositol 4-monophospate, due to its binding capacity of the pleckstrin homology domain towards phosphatidylinositol 4-monophospate. From this study we conclude that the membrane matrix surrounding ceramide, that is ceramide miscibility, is largely affecting the transfer activity of CERT.Biochimica et Biophysica Acta 09/2010; 1808(1):229-35. · 4.66 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: HET-C2 is a fungal protein that transfers glycosphingolipids between membranes and has limited sequence homology with human glycolipid transfer protein (GLTP). The human GLTP fold is unique among lipid binding/transfer proteins, defining the GLTP superfamily. Herein, GLTP fold formation by HET-C2, its glycolipid transfer specificity, and the functional role(s) of its two Trp residues have been investigated. X-ray diffraction (1.9 Å) revealed a GLTP fold with all key sugar headgroup recognition residues (Asp66, Asn70, Lys73, Trp109, and His147) conserved and properly oriented for glycolipid binding. Far-UV CD showed secondary structure dominated by α-helices and a cooperative thermal unfolding transition of 49 °C, features consistent with a GLTP fold. Environmentally induced optical activity of Trp/Tyr/Phe (2:4:12) detected by near-UV CD was unaffected by membranes containing glycolipid but was slightly altered by membranes lacking glycolipid. Trp fluorescence was maximal at ∼355 nm and accessible to aqueous quenchers, indicating free exposure to the aqueous milieu and consistent with surface localization of the two Trps. Interaction with membranes lacking glycolipid triggered significant decreases in Trp emission intensity but lesser than decreases induced by membranes containing glycolipid. Binding of glycolipid (confirmed by electrospray injection mass spectrometry) resulted in a blue-shifted emission wavelength maximum (∼6 nm) permitting determination of binding affinities. The unique positioning of Trp208 at the HET-C2 C terminus revealed membrane-induced conformational changes that precede glycolipid uptake, whereas key differences in residues of the sugar headgroup recognition center accounted for altered glycolipid specificity and suggested evolutionary adaptation for the simpler glycosphingolipid compositions of filamentous fungi.Journal of Biological Chemistry 04/2010; 285(17):13066-13078. · 4.60 Impact Factor
Publication Stats
501 | Citations | |
206.05 | Total Impact Points | |
Top Journals
Russian Academy of Sciences
- Institute of Inorganic Chemistry
Moskva, Moscow, Russia
Pacific Institute of Bioorganic Chemistry
Wladiwostok, Primorskiy, Russia
University of Minnesota Duluth
Duluth, Minnesota, United States


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Easy-to-follow video tutorials help you learn software, creative, and business skills.Become a member
In this lesson, you'll learn how to change existing attribute values and how to alter attribute definitions, without exploding their blocks. Open the Office 6 project file. Suppose we want to change the employee who works in Room 104 and we want to update their last name in this room tag. You can do that by going up here, to the Edit Attribute command in the block panel, which is on the Insert tab of the ribbon. This launches the command eatedit, which stands for Enhanced Attribute Editor.
Click anywhere on the room tag block to open this dialog box. It shows you both of the tags which are part of this particular block. Click on Lname, and you'll see its value appear down here. Highlight that and just type in the new employee name, which is Montgomery. (audio playing) Type it all in capital letters like all the other employee last names and click OK. (audio playing) Now we've successfully changed the value but this particular last name is too long to fit within the rectangle that was designed for this particular block. We can fix that by narrowing the width of this particular attribute. To do that let's go back into the enhanced attribute editor, but this time instead of going up here an selecting it, we'll just double-click on the block itself.
(audio playing) This automatically opens the dialog box. Select Lname, and then go to the Text Options tab. Here you can change the width factor, (audio playing) highlight the value and type 0.7. Click OK (audio playing) and this singular block reference has been updated. If you look at the other room tags, you'll see that they're just the same width as they were before. The text width is defined by the text style used in the attribute definitions. Suppose you wanted to update all the room tags now to use the narrower width that you see in Room 104.
That's possible with the Block Attribute Manager. You can open that here by clicking Manage Attributes on the Block Definition panel. The command is Batman. (audio playing) Select Room Tag from this drop-down menu. Notice that we don't see any employee last names here. That's because the Block Attribute Manager allows you to edit the attribute definitions. Double-click on Lname to open a secondary dialog box.
Then go to it's text options tab and change the Width factor to 0.7. Click OK and all the existing room tags are updated because we've changed the way the attribute definitions appear. Click OK. Now suppose you want to edit (audio playing) some of these furniture blocks. I'll double-click on this armchair (audio playing) and we see that the Enhanced Attribute Editor opens up. I could edit the price or manufacturer values down here. There's also a third invisible attribute that was defined within this block. model.
We don't see it here because it used a constant mode. So we're not able to edit that. When we insert the arm chair, we're asked to verify the price. But we're not asked about the manufacturer and that's because the manufacturer was set to the preset mode. However, you can edit that here (audio playing) in the Enhanced Attribute Editor. If you want to edit the model, you have to do that in the Block Attribute Manager.
Suppose we do want to change the model number, we'll cancel out of here, go to Manage Attributes, select Armchair (audio playing) and double-click on model. (audio playing) Let's change the default model number (audio playing) to A333. OK and OK. (audio playing) All of the armchair blocks in this drawing had been updated with that invisible default value.
So in this video, you'll learn how to edit attribute values and attribute definitions using the eatedit and batman commands. You now have the skills to design, implement, and modify attributes.
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text: Hmmm, looking at the images, it appears the gold has worn through to the base metal and separated in a line across the case. It hasn't...just a function of poor lighting I think. This little watch looks much better than that. Let me try again with some images here at my desk.


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The Legend of Korra - Book One: Air
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July 3 2012, 01:59 AM
Re: The Legend of Korra - Book One: Air
Mr Light wrote:
I really hope Iroh is a regular character now. He was so bad ass! Fall out an airplane? Oh no problem! Of course, in the old show, weren't fire-benders only able to fire-jet-fly under Sozin's Comet...?
I just saw this again, and nothing Iroh did really constituted "flying." He used the fire jets twice -- once to boost himself onto a plane that was a few dozen meters ahead of him, not long enough to constitute flight, and once when he was falling from a plane, to aim his descent so that he'd land on another plane.
But I have to wonder -- if he's commanding a fleet of ships, why is he General Iroh instead of Admiral Iroh?
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Alma-nac's Slim House named London's best extension
Alma-nac's 2.3m-wide house won the award for innovative extensions at the fourth annual 'Don't Move, Improve!' awards last night (05.12.13)
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Recent news
Press Release
BRIC and Brooklyn Historical Society Announce "Mapping Brooklyn" ExhibitionBRIC and Brooklyn Historical Society (BHS) are pleased to co-present "Mapping Brooklyn," a new exhibition featuring contemporary art works that use mapping and cartography as themes alongside actual historic maps. Curated by Elizabeth Ferrer, Vice President of Contemporary Art at BRIC, and spanning the galleries at BRIC House (647 Fulton Street) and Brooklyn Historical Society (128 Pierrepont Street), "Mapping Brooklyn" explores the myriad ways that maps can represent practical matters such as wayfinding, property ownership, population shifts and war strategy, while also navigating the metaphorical, the psychological and the personal. At both venues, historic maps and contemporary works will be in dialogue, suggesting common themes—the desire to explore, chart, and analyze territory—and highlighting the innovative ways that contemporary artists use mapping, cartography and exploration, to reveal data, ideas and emotions.
Press Release
BRIC Announces OPEN (C)ALL:The Artist's Studio ExhibitionBRIC will mount its first open-call exhibition, "OPEN (C)ALL: The Artist's Studio," from January 14 to February 8, 2015. The exhibition will be presented in the 3,000-square-foot Gallery of BRIC House and will be open to all members of the online BRIC Contemporary Artist Registry or to those artists who join the BRIC Artist Registry during the exhibition submission period (through Jan 7, 2015). BRIC's Registry is free and open to artists who were born, live, or work in Brooklyn.
For the "OPEN (C)ALL" exhibition, Registry artists may submit a single work of art of their choosing and representing their practice. All work submitted within guidelines will be shown, while space is available.
Press Release
BRIC Announces 2014–2015 Winners of "Fireworks" Residency ProgramBRIC is pleased to announce the 2014–2015 winners of "Fireworks," BRIC's residency and commission program. "Fireworks" is designed to bring together artists of different disciplines who share a vision in development of new, large-scale multidisciplinary work. BRIC provides technical and financial resources to facilitate the collaborative development of creative projects that cross or erase artistic boundaries. The 2014–2015 winners are Aisha Cousins, Greg Tate, and Burnt Sugar The Arkestra Chamber for their project "Brer Rabbit The Opera: A Funky Meditation On Gentrification" and Baba Israel, YAKO 440 and Leo Kay for their project "The Spinning Wheel."
Press Release
BRIC presents the "BRIC Biennial: Volume I, Downtown Edition"BRIC proudly announces the launch of a major new initiative, the "BRIC Biennial," which will present Brooklyn artists creating work in a variety of different media and demonstrate the significance of Brooklyn as a vital center for art making and innovation, perhaps the most important in the world today. Each edition of the "Biennial" will focus on different geographic neighborhoods, providing the curators an opportunity to dig deeply and discover the diversity of talent to be found throughout the borough. The "BRIC Biennial: Volume 1, Downtown Edition," will survey artists based in Downtown Brooklyn and adjacent neighborhoods such as Fort Greene and Boerum Hill, a fitting focus given the location of BRIC House in Downtown Brooklyn. Volume I of the "BRIC Biennial" will include 27 artists who encompass different generations and cultural backgrounds and work with diverse artistic formats and themes. The exhibition will be on view from Sept 20-Dec14, 2014, with an opening reception on Sept 19, from 7-9pm.
Press Release
BRIC Presents "Transcommunality: Laura Anderson Barbata, Collaboration Beyond Borders"BRIC is pleased to present "Transcommunality: Laura Anderson Barbata, Collaboration Beyond Borders" this summer at BRIC House, July 10 - August 31. The exhibition documents the work of Mexican-born, New York-based artist Laura Anderson Barbata; focusing on the decade-long project she pursued with stilt-walking communities in Trinidad and Tobago, Mexico, and Brooklyn. Her project highlights the vitality of the moko jumbie stilt walking tradition and demonstrates the possibility of using this storied art form as a platform for social contemporary performance, group participation and protest.
Press Release
BRIC, Mark Morris, and Irondale present "Brooklyn Creative Arts Lab" Summer Youth Program, July 7-26Three of Brooklyn's leading arts and cultural institutions–BRIC, Irondale Ensemble Project and Mark Morris Dance Group–have teamed up to create Brooklyn Creative Arts Lab (BCAL), a new summer arts program that invites youth, ages 10-13 (rising 6-8th graders), to engage in an exceptional, multidisciplinary experience. Thirty-six participants will explore dance, media, theater and visual art under the direction of professional artists in the various forms. BCAL will take place July 7-26, weekdays from 9am-4pm (extended day options available).
Press Release
BRIC Presents "#InstaSelfieParadise: The 26th Annual Student Art and Media Education Exhibition" and Two Other Concurrent ShowsBRIC completes its inaugural exhibition season in the Gallery at BRIC House, the organization's new 40,000-square-foot multi-disciplinary facility in Downtown Brooklyn, with "#InstaSelfieParadise", BRIC'S "26th Annual Student Art and Media Education Exhibition." The show highlights student work by young artists taking part in BRIC residencies in public schools. On view May 14 – June 15, 2014 and curated by Hawley Hussey, BRIC's Director of Contemporary Art Education, this year's student exhibition features artistic contributions in the fields of art and media from students age 4-17, in 18 public schools across Brooklyn as well as in Queens and the Bronx. Two exhibitions will run concurrent to the student exhibition, "Expanded Practice: A Survey of Work by BRIC's Teaching Artists," curated by Jenny Gerow and "Small Solos: Vandana Jain | Melissa Godoy Nieto", curated by Elizabeth Ferrer. BRIC House is located at 647 Fulton Street in Downtown Brooklyn. Gallery hours are Tuesday–Sunday 10am–8pm, and Sunday 10am–6pm. An opening reception will be held on Wednesday, May 14, from 6-8pm.
Press Release
Summer is coming! BRIC Announces 2014 Celebrate Brooklyn! Festival LineupBRIC is pleased to announce the lineup for its 36th annual Celebrate Brooklyn! Performing Arts Festival, which will comprise 31 performances, June 4 – August 9. The programming, reflective of Brooklyn's eclecticism and diversity, will feature a wide array of free, world-class performances in the singular environs of the Prospect Park Bandshell.
The Festival welcomes Squarespace, a creative tools company based in New York City, as presenting sponsor. Serving Brooklyn's characteristically enterprising, creative and diverse communities, Squarespace offers services that, like BRIC, emphasize both accessibility and quality.
Press Release
BRIC Announces 2014 Celebrate Brooklyn! Dance Parties at Brooklyn Bridge ParkBRIC, producer of Celebrate Brooklyn!, the borough's premier outdoor summer festival, returns with the fourth annual Celebrate Brooklyn! Dance Parties. The free series, held on Brooklyn Bridge Park's Pier 1 on three consecutive Thursday evenings in May (8, 15 & 22), serves as a "bridge" to Celebrate Brooklyn's 36th annual season, which starts June 4 with a free performance by Janelle Monáe and runs throughout the summer at the Prospect Park Bandshell. Please find a schedule with programming details below.
Sponsored by Brooklyn Bridge Park Conservancy, the Celebrate Brooklyn! Dance Parties feature a varied lineup of bands paired with DJs, on a great lawn with spectacular views of the city, plus dance lessons, free valet bike parking, food trucks and more. The free dance parties will begin at 7:00 PM each night and end by 10:00 PM. Pier 1 can be entered at the foot of Old Fulton Street at the Brooklyn waterfront or from the new Squibb Park Bridge.
Press Release
BROOKLYN INDEPENDENT MEDIA RECEIVES NEW YORK EMMY® AWARDBRIC's Brooklyn Independent Media team has been recognized by the New York Chapter of the National Academy of Television Arts and Sciences with a New York Emmy® Award for Best Arts Feature/Segment.
This is the first win for Brooklyn Independent Media, BRIC's original production team, which has been nominated in the past for the New York Emmy Award, which focuses on filling the gap in Brooklyn.
For Public Relations and Publicity inquiries, please contact:
Binta Vann-Joseph
Director of Marketing & Communications
Blake Zidell & Associates
BRIC Contemporary Art Calendar
- January 14-February 8, 2015 · 10:00 AM-8:00 PMOPEN (C)ALL: THE ARTIST'S STUDIOGallery at BRIC HouseFREE
- February 25, 2015 · 7:00 PM-9:00 PMOpening Reception for Mapping BrooklynGallery at BRIC HouseFREE
- February 26-May 3, 2015 · 10:00 AM-8:00 PMMapping BrooklynGallery at BRIC HouseFREE
All Contemporary Art Events »
BRIC Performing Arts Calendar
- February 5, 2015 · 7:30 PM-9:00 PMB-Side: IampopulaBRIC House StudioFREE
- February 12, 2015 · 7:30 PM-9:00 PMB-Side: IndigeSoulBRIC House StudioFREE
- February 19, 2015 · 7:30 PM-9:00 PMB-Side: Tamar-kaliBRIC House StudioFREE
All Performing Arts Events »
BRIC Community Media Calendar
- January 1-January 31, 2015 · All DayHow To Get Your Own TV ShowFREE
- January 9-February 12, 2015 · All DayB Free Awards 2015 Submissions OpenFREE
- January 29-February 20, 2015 · All DayMedia Share: Non-Profits Apply Today!BRIC Arts | Media HouseFREE


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I've been doing a lot of writing lately. Not here, but in a blog that I share with only myself. After discovering that I had lingual nerve damage I completely shut down. I lost all motivation and I spent my days crying and feeling sorry for myself. It sure didn't help that I was staying up until 3 AM on message boards reading other peoples depressing stories about this injury. After almost 2 weeks of self-pity and shutting myself out from the world, I'm starting to feel like myself again. My nerves are healing, slowly yes, but progress is being made. I've learned quite a few things during this whole process and one of those things is that life is too short to be sitting in house and being afraid all the time. What happened to my nerve was devastating to me, but it could have been a lot worst. In fact, for a lot of people, a damaged lingual nerve would be a lot better than what they're going through. You know, I've spent pretty much my whole life saying "why me?" and the other day my husband made a good point. He told me that things happen to people every day, bad things... things that make people wonder "why them." Well, its because that's just a part of life. Having bad things happen to you is normal. You see someone with a physical or mental disability and you think that's not normal, but it is. Whatever problem you may have is normal and universal. No one is walking around this planet absolutely perfect and if they were, that wouldn't be normal.
I've really developed an appreciation for life. I'm not saying that this experience has healed me from my social anxiety, because it hasn't. However, this experience has shown me that life is too damn short to let this control my life. I went in to get my wisdom teeth pulled and now I could have permanent nerve damage. Anything can happen at any second and completely turn your world around. If it does, I promise you, you will look at your social anxiety and wonder, what the hell was I thinking. Why would I let irrational thoughts keep me from living my life. You only get ONE life, just ONE and once its over, its over. Live your life to the fullest. It doesn't matter how afraid you are, or what people may say about you, because at the end of the day this is your life and you're the one who has to be happy. |
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Phone Skins
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Martynas, I want to live in the world you have created. My next life will be lived inside your paintings!
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Dr. Kavita R. Kongara, MD
Gastroenterology, Atlanta Gastroenterology Associates
- 550 Peachtree St NE Ste 1600
Atlanta, GA 30308 - 1 Office Location
- (404) 881-1094
Dr. Kavita R. Kongara graduated from the University of Missouri, Kansas City School of Medicine in 1993. She works in Atlanta, GA and specializes in Gastroenterology. Dr. Kongara is affiliated with Dekalb Medical Center, Emory University Hospital Midtown and Piedmont Atlanta Hospital. She speaks English and Spanish.
Gender: Female
Years in Practice: 22 Years
Languages Spoken: English, Spanish
Medical School: University of Missouri, Kansas City School of Medicine
Graduation Date: 1993
Hospital Affiliations: Dekalb Medical Center, Emory University Hospital Midtown, Piedmont Atlanta Hospital
Specialties: Gastroenterology


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Date: 1912 ca.
Description: Glenn Curtiss sold two hydroplanes (NS 1 & 2) to the U.S. Navy and continued to test them independently from their base also located on North Island. This...
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Description: A view of the facade and side of a high school building. A postman walks along the sidewalk, looking at the camera, while a man sits in his carriage, also...
Date: 1947-05-11
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Date: 1941
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Date: 1912-09 ca.
Description: Two men sitting in a racecar, with the driver of the car, possibly Harry Endicott, wearing a leather mask with goggles. Two men stand in the background.
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Date: 1930 ca.
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Date: 1931-10-14
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Town Square
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Scherer found guiltyThe jury has found Ernest Scherer III guilty of charges that he killed his parents in March 2008, after ending their deliberations...
Original post made on Mar. 28, 2011Last comment by Anon, on Apr 5, 2011 at 6:57 pm | 25 comments | 2601 Views
Budget concerns, pension reform highlight meetings in San Francisco, San Jose, Sonoma CountyThe San Jose City Council voted Tuesday to move forward with an analysis of a proposal from Mayor Chuck Reed to rein in retirement...
Original post made on May. 25, 2011Last comment by Concerned, on May 31, 2011 at 1:03 pm | 25 comments | 1659 Views
Downtown's Farmer Restaurant to close June 5The Farmer Restaurant in the Pleasanton Hotel on north Main Street will close after its last diners are served on Sunday,...
Original post made on May. 26, 2011Last comment by common sense, on May 28, 2011 at 4:41 pm | 25 comments | 1220 Views
Supervisors propose boundary changes to split Pleasanton into 2 districtsTwo Alameda County supervisors took a plan for redrawing their district boundaries to Dublin last night in a public hearing...
Original post made on Jun. 1, 2011Last comment by common sense, on Jun 4, 2011 at 9:36 pm | 25 comments | 1388 Views
Complaints continue about parking at 24 Hour Fitness facilityParking has gotten better at 24 Hour Fitness's new facility on Willow Road, but there are still problems during peak hours,...
Original post made on Jul. 8, 2011Last comment by BMJC, on Jul 14, 2011 at 2:15 pm | 25 comments | 2104 Views
Council meets tomorrow on plan to add more affordable housingThe City Council is expected to wrap up more than a year of community meetings, public hearings and studies tomorrow night...
Original post made on Jul. 18, 2011Last comment by Norman, on Jul 22, 2011 at 8:53 am | 25 comments | 1458 Views
The Unfair Focus on Bachmann HeadachesI would like to think I'm a rationale human being. I look at the news and get upset just like everyone else. Unfortunately,...
Original post made by Holden on Jul. 20, 2011Last comment by Rivera, on Jul 26, 2011 at 10:53 am | 25 comments | 2133 Views
Hayashi, represented by attorney, skips court appearanceA state assemblywoman accused of shoplifting at a Neiman Marcus store in San Francisco's Union Square in October did not...
Original post made on Nov. 16, 2011Last comment by Gina Channell-Allen, on Nov 17, 2011 at 10:20 am | 25 comments | 1381 Views
Support group for depression and bipolar meets on WednesdaysDepression Bipolar Support Alliance, DBSA, is a support group for people who live with depression, bipolar and other disabilities....
Original post made on Nov. 25, 2011Last comment by Family member, on Nov 29, 2011 at 6:10 pm | 25 comments | 3368 Views
Why is there no longer Christ in Christmas ?All around town, I no longer see a lot of Christ in Christmas.Where are the Holy Family exhibits on people's lawns? Instead...
Original post made by Lee on Dec. 12, 2011Last comment by Resident, on Dec 15, 2011 at 4:16 pm | 25 comments | 1194 Views
Big bong battleWalk into any convenience store, and you'll probably find drug paraphernalia behind the counter in the form of rolling papers...
Original post made on Dec. 15, 2011Last comment by Sandi, on Dec 20, 2011 at 12:07 pm | 25 comments | 3984 Views
Police report: Foothill teacher was busted in drug sale stakeoutThe Foothill High School teacher arrested on drug charges in October was caught smoking oxymorphone, a narcotic, in her car,...
Original post made on Dec. 22, 2011Last comment by 925, on Jan 12, 2012 at 4:31 am | 25 comments | 2456 Views
California workers, Dems want to give you a 3% pay cutThe California Legislature, dominated by Democrats who hold a majority just shy of 2/3, have had difficulty convincing the...
Original post made by jimf01 on Feb. 24, 2012Last comment by Lewis, on Mar 2, 2012 at 10:34 pm | 25 comments | 2613 Views
Plesanton school board to consider borrowing from technology fund to pay for facilities planThe Pleasanton school board tonight will look at the possibility of borrowing money from a fund set up with the sale of property...
Original post made on Mar. 13, 2012Last comment by Radumton, on Mar 13, 2012 at 9:03 pm | 25 comments | 1588 Views
Where has all the fun gone?When I was growing up in the South Bay, the fun and recreation opportunities seemed endless. We had ice and roller skating...
Original post made by Curious on Apr. 13, 2012Last comment by Curious, on Apr 16, 2012 at 9:43 am | 25 comments | 2454 Views
Dublin Councilman Eric Swalwell seeking congressional seat in 2012 electionEric Swalwell, an Alameda County deputy district attorney and Dublin City Councilman, announced his candidacy Wednesday for...
Original post made on May. 1, 2012Last comment by Uh, on May 4, 2012 at 5:12 pm | 25 comments | 3131 Views
Good Place To Teach Teenager To DriveMy son hasn't had any lessons yet, he passed the written driver's test. I want to take him to some quiet area to give him...
Original post made by Sarah on May. 21, 2012Last comment by Maria, on May 13, 2013 at 12:07 pm | 25 comments | 4371 Views
Beyond Bias: Media Blackballs Anti-Obama Book (No. 1 on NYT Times for 4th Week)This is wayyyy beyond being biased. As the author of the following article states, "this is an in-kind contribution to Obama...
Original post made by Beyond Biased Media on Jun. 13, 2012Last comment by Enzo, on Aug 21, 2012 at 12:17 am | 25 comments | 2387 Views
Job fairs planned for Paragon Outlets mall, scheduled to open Nov. 8Hiring fairs for Livermore's new Paragon Outlets mall will be held from 10 a.m. to 2 p.m. Tuesday, Sept. 11 and Tuesday,...
Original post made on Aug. 2, 2012Last comment by Cholo, on Aug 19, 2012 at 9:13 pm | 25 comments | 31063 Views
Romney and Women's RightsFound this on the web - http://articles.sun-sentinel.com/2012-08-21/news/sfl-commentary-sobel-oped-82312_1_individual-rights-women-abortions...
Original post made by Gail on Oct. 3, 2012Last comment by Resident, on Oct 6, 2012 at 6:29 am | 25 comments | 2343 Views
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Cleaning my PC or cleaning my wallet?
By Roz Rogoff | 15 comments | 1,593 views
Selma Soliloquy
By Tom Cushing | 12 comments | 1,372 views
Swalwell running for Congress again, will pass on Senate campaign
By Tim Hunt | 3 comments | 1,330 views


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Good news, everyone! New stuff is starting to hit - I personally saw a Target in Phoenix, AZ have a couple of Wullfwarro/Wookiee Warrior and Sabine Wren/Stormtrooper Star Wars Mission Series 2-packs at $9.99 a pop this evening before dinner. (I didn't see any of the other new ones.) If you're in the market for these, either order online at your favorite store or gas up the car!
This is great! Tonight's episode of Star Wars Rebels is "Idiot's Array," which lets you know right from the start that this is an episode for the hardcore loyalists from the 1980s. Originally appearing in the novels and some other Expanded Universe materials, the episode title lets you know that a familiar face will make an appearance, voiced by one of two special guest voice actors. And it was really fun, too!
If you liked the more episodic one-shot stories of old and love easter eggs aimed specifically at fans like you, this is a real gem of an installment. I daresay it's my favorite of the season and those who hate spoilers, well, too bad. Read on for more!
The back half of Star Wars Rebels begins here with "Path of the Jedi," which treads very familiar ground. Like much of the series, various themes are brought back in a new form along with recreations of music and scenes you've seen in the movies and elsewhere. This week, we get the much-promoted return of Frank Oz as Yoda in a voiceover role during a Jedi temple sequence which does raise a number of in-Universe questions, like "So if there's only 10,000 Jedi, how come there are a bunch of very expensive, very ornate temples all over the galaxy?"
Now that we're back from break, let's see what's new in the Force. Read on for more!
This is a good one. Star Wars Rebels finds its voice with "Empire Day." There are cameos, there's a lot of action, and best of all it's a fun ride. You get to see some fun new things, and the episode not only shows you someone else with Lobot's cybernetic implant, but we actually get a decent hint as to what the future for this show may hold!
This is the episode you'll show your friends who have their arms crossed and refuse to give it a chance - it's just that good. Standard spoilers apply, plus a warning/guarantee of another Kenner cameo. Read on for more!
Now that the figures are hitting shelves, Star Wars Rebels ups its game with the exciting "Out of Darkness." Being trapped on an alien world with dangerous local life forms is nothing new (see: "Rookies") but this episode shifts the focus from a group of trained military men to Hera and Sabine. Star Wars has historically given women little to do, especially in groups - seeing two of our heroes take on some sort of cat roach menace during a supply run where they really have a reason to be afraid of the dark made for a good showing.
Gorgeous space scenery and space babysitting await you. Read on for more!
The pace of Star Wars Rebels continues to ramp up with "Breaking Ranks," an entertaining but still unfortunately small-scale tale of the Vader Youth. We get a couple of stock Imperial officers (plus a couple of returning faces), a group of kids, and a relatively familiar plot that (I hope) sets up an arc for the future.
You get a few seconds of the Inquisitor, a few new faces, and the first indication of a solid missed opportunity in the action figure line. Read on for more!
Now this is a bit better. In "Rise of the Old Masters," Star Wars Rebels gives us no rising and only one master. It also ties in perfectly with the bonus scene featuring Darth Vader, and aligns nicely with this week's Halloween holiday. You get some cool cameos, but still a very sparse episode - it is, however, more fun to watch and a little ghoulish to dwell upon.
Spoilers await you after the break, but let me tell you this: you get to se a new villain in action, a possible new recurring character voiced by a Star Trek alumnus, and the Phantom in action. Read on for more!
A very McQuarrieish Darth Vader's disembodied helmet floats above the Inquisitor in a Star Wars Rebels scene airing on ABC earlier tonight. In it, exposition takes place. Did you miss it? We embedded a crude copy of the 1-minute sequence from the YouTubes after the break.
As Fake Shemp was unavailable, James Earl Jones will voice Darth Vader on en encore of Star Wars Rebels: Spark of Rebellion airing on ABC Sunday before the Disney Princess Live Action Mom Placation Hour. (You can read our review of the original DisneyXD airing here.)
Star Wars Rebels goes back to square one, and gives us a shopping trip in Fighter Flight. In case you forgot you were watching a kid's show that isn't exactly being given a ton of thought, well, here we are. The good guys go grocery shopping and come home with a new toy. And you'll see some old toys off in the distance.
Bringing things back to the Star Trek spin-offs, Rebels is somewhat consistent. The first seasons of those shows had some pretty bumpy times as we watched Tom Paris and Harry Kim hang out. Zeb and Ezra are this show's bickering buddies, and their rivalry continues with a trip to go do the shopping.
Star Wars Rebels returns to a normal, shorter format with Droids in Distress. Is fan service enough?
If you know your sci-fi history, it's not uncommon to trot out guest stars early on a spin-off. Star Trek: The Next Generation's first regular episode was basically a remake of the original series' second episode - crazy drunk sickness crew, swapping the super-cool Sulu fencing for the super-creepy Data nailing Tasha Yar. Star Trek: Deep Space Nine had guest stars Lursa and B'Etor on its first regular installment, and The Clone Wars' first real installment? Yoda reenacts (preenacts?) Luke's Jedi training from The Empire Strikes Back. What Rebels does is bring back R2-D2 and C-3PO! The snappier exposition dump has more interesting battles than the pilot movie, and manages to do some more worldbuilding while having a bit more fun. Read on for more - and download the episode for free on iTunes until Apple changes their mind!
It's super tall! The Star Wars Rebels AT-DP Vehicle is able to seat one 3 3/4-inch scale action figure with another popping out the top hatch. It has moving legs, a firing rocket, and a rotating head - all of which you can see, after the jump.
Apparently Zeb has a cool hat! This is the Star Wars Rebels Hero Series Deluxe Zeb action figure. Enjoy it in good health. There are pictures after the jump.
Sometimes we get toys from movies and sometimes we get movies from toys. NYCC revealed a few good shots of Ezra Bridger's Lightsaber... Gun... Slingshot.... thing from Star Wars Rebels. Take a look!
Ah, armchair reporting! It's great. Hasbro sent along a batch of photos of new Star Wars goodness from their "Twas The Night Before Party." In here, you'll find 3 3/4-inch Star Wars The Black Series C-3PO, Princess Leia in Boushh Disguise, Mosep Binneed, Commander Thorn, Han Solo in Carbonite, and a pair of Jawas! What's not to love?


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OC3D Reviews ›› All
Bitspower ROG Full Cover Blocks Rampage Formula Hero Ranger Gene & Impact
CPU & Mainboard | 3rd November 2014
The whole current ROG motherboard range get some sexy Bitspower full cover loving!
Xigmatek Aquila Review
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The new Xigmatek. Perhaps a not so small, small form factor case?
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Had enough of colourful hardware? Want to go for the modern monochrome look in your next build? MSI have just the thing for you.
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Microsoft Lost The Plot Over Zune Advertising?
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Have Ballmer, and the gang at Redmond lost the plot over the Zune's advertising campaign? Read on to find out more...
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Matthew Fogg | 2nd January 2007
Intel's upcoming Santa Rosa platform for Notebooks employs something known by its code name as the "Robson" module, that incorporates NAND Flash in a solid state disk-cache design. Read about it here...
VIA Announces EPIA Mini-ITX Platform For x86 Consumer Electronics
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VIA Technologies today announced the VIA EPIA EX-Series Mini-ITX mainboards, the first of VIA's compact platforms to feature the new VIA CX700M2 system media processor.
The OCZ Nvidia GeForce 8800GTX Is Coming
Matthew Fogg | 29th December 2006
As many of you have heard from the soft launch at the APAC summit, OCZ videocards are on the way. Read on to find out more.
Intel Core i7 5820K Review
CPU & Mainboard | 29th October 2014
Fancy upgrading to the Haswell-E range but can't afford the 5960X? Perhaps the Core i7-5820K will be just the thing.
Roccat Tyon Mouse and Siru Surface Review
Input Devices | 27th October 2014
Roccat releasing a new mouse is a rare event, and we have their new flagship, the Tyon, up for review.
MSI X99S XPOWER AC Review
CPU & Mainboard | 22nd October 2014
It's a lengthy all caps review title and that can only mean one thing, the MSI XPOWER is back in the OC3D Bench system.
AMD Athlon 860K Black Edition CPU Review
CPU & Mainboard | 21st October 2014
If you want a budget gaming system, does AMD's budget oriented Athlon CPU cut the mustard?
Sandisk Extreme Pro 480GB SSD Review
Storage | 20th October 2014
The latest iteration of the Sandisk Extreme SSD is here and we give it a quick spin.
Alphacools New Range Of GPU Blocks For Nvidia 7950 GTX and 8800 series Cards
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Hot off the press! We have the latest news on the new range of GPU waterblocks from Alphacool. Read on to find out more...
New Crysis Screenies
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Wanting some more eye candy from one of the most anticipated games of 2007? Read on to find out more...
Sapphire Quad Crossfire Gets Closer
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Sapphire is making a dual RV570 board with internal Crossfire. Read on to find out more...
Americas Army Level Designer Released
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The latest version of the Army's own FPS, America's Army, is out, bringing with it a tool to make your maps and missions.
Intel Core 2 Quad Q6600 On The Horizon
Matthew Fogg | 22nd December 2006
It looks like Intel will make their lower priced follow-up to the quad-core Core 2 Extreme QX6700 processor available soon.
Changes To The Swiftech Waterblock Lineup
Matthew Fogg | 21st December 2006
There appears to be some changes occuring in the Swiftech waterblock lineup. Read on to find out more...


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Book your room at Pierre & Vacances Residence Les Terrasses d'Azur
1 bedroom apartment for 4
Max Occupancy: 4 guests (up to 3 children)Studio For 4
Max Occupancy: 4 guests (up to 3 children)1/2 bedroom apartment for 5/6
Max Occupancy: 6 guests (up to 5 children)3 Bedroom Apartment for 8 People
Max Occupancy: 8 guests (up to 7 children, 3 infants)Slopeside residence with downhill skiing
Located in the mountains, this ski-in/ski-out residence is in Isola, within minutes of Isoliane Adventure Park, Isola 2000 Ski Resort, and winter sports such as cross-country skiing and skiing lessons. Nearby attractions also include Col de la Lombarde.
Property Features
Pierre & Vacances Residence Les Terrasses d'Azur provides ski-in/ski-out access, ski storage, wireless Internet access (surcharge), and multilingual staff.
Room Amenities
Televisions come with satellite channels. Guestrooms also feature kitchenettes, refrigerators, and wireless Internet access (surcharge).
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The family that wrestles together ... Liberty Lake�s Beard clan known for grappling success
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Sports Brief 9/12/2012 11:29:16 AM
Weber, 18 and a recent Central Valley High School graduate, competed in the 100, 400 and 800 meter T54 races. She didn't qualify for the final rounds - just missing the 100 meter final by .08 seconds - but that didn't stop the University of Illinois-bound athlete from aiming for the future.
"Better watch out Rio," she said on her Facebook page, referring to the next Paralympic Games in Rio de Janeiro, Brazil, in 2016. "I'm coming for ya!"
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Feather & Black sales boosted by multichannel
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Adachi, Motonari, Lockwood, David J (Eds.)
2006, XVI, 318 p.
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Novel system performance through nanostructuring has been recognized in many branches of science in the last decades. The requirement for inventing a new technology paradigm has created research opportunities for scientists in very wide range of disciplines. In order to fully realize the tremendous potential of nanostructure science and technology, the extremely important challenges today are how to exploit synthetic methods for structures regulated at the atomic scale and to construct materials across the hierarchy of length scales from the atomic to mesoscopic and/or to macroscopic scale. This book comprises an overview of a wide variety of different approaches towards the synthesis of nanoscale materials and the hierarchical assemblies produced from them under the common theme of self-organization mechanisms via chemical and bio-inspired methods. The book covers many of the exciting and recent developments from basic research to applications in the field of self-assembly of nanostructures that are of general interest to a broad community of established and postgraduate researchers in physics, chemistry, biology, engineering, and materials science.
Content Level » Research
Keywords » Nanotube - biotechnology - chemistry - nanostructure - organization - physics - science - self-organization - sol-gel - surface - technology - thin films
Related subjects » Inorganic Chemistry - Materials - Nanotechnology - Optics & Lasers - Physical Chemistry
Get alerted on new Springer publications in the subject area of Nanotechnology.


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By: Hitsugaya
3 Second mode. Normal speed. Music didn't record so i put another song in there.
Views: 903 | Posted: 05/22/2011
By: aetharr
Just thought I'd upload this, this is me playing stage IX of Yuusha30, aka Half-Minute Hero. This game is awesome... for me, it has a feel of WarioWare, but obviously quite different.. anyway. I was gonna make something funny.. but couldnt be bothered in the end, something like It's a Mini adventure like the Mini car adverts.. but i dunno... anyway, enjoy :)
Views: 2,530 | Posted: 03/30/2010
By: panzerdrako
whoa!...that ost in the press start screen sound great...it is like those band cover old 8-bit music into metal...I WILL GET IT!!!!
Views: 820 | Posted: 02/19/2010
What is this gigantic thing that stands before me?
Views: 4,418 | Posted: 11/04/2009
Please wait, Father. I'll cure your illness right away!
Views: 3,587 | Posted: 11/04/2009
Ahahahaha, I set you up the bomb!
Views: 9,685 | Posted: 11/04/2009
What's wrong, my Sage? You shouldn't stand there.
Views: 3,385 | Posted: 11/04/2009
Ready for hard mode?
Views: 7,176 | Posted: 07/30/2009
Japanese Quest 6 Gameplay for the Hero character.
Views: 5,193 | Posted: 07/02/2009
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Release Date: 01/26/2015
The Original Macintosh 128k black and white and Apple IIGS 4-bit color versions of the MacVenture Series: Uninvited,...
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Release Date: 01/30/2015
Life is Strange is a five part episodic game that allows the player to rewind time and affect the past, present and...
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The new game from Dark Souls director Hidetaka Miyazaki.
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Book your room at Brisbane International Windsor
Deluxe Double Room
Max Occupancy: 2 guests (up to 1 child, 1 infant)Executive Room, 1 Queen Bed
Max Occupancy: 2 guests (up to 1 child, 1 infant)Deluxe Twin Room
Max Occupancy: 2 guests (up to 1 child, 1 infant)Executive King
Max Occupancy: 2 guests (up to 1 child, 1 infant)Hotel Suite
Max Occupancy: 2 guests (up to 1 child, 1 infant)4-star motel in Windsor with a restaurant
With a stay at Brisbane International Windsor in Windsor, you'll be close to Perry Park and Roma Street Parkland.
This 4-star motel is within close proximity of Twelfth Night Theatre and Royal Children's Hospital.
Make yourself at home in one of the 61 air-conditioned rooms featuring minibars and flat-screen televisions. Complimentary high-speed (wired) Internet access keeps you connected, and digital programming is available for your entertainment. Private bathrooms have complimentary toiletries and hair dryers. Conveniences include phones, as well as desks and coffee/tea makers.
Enjoy recreational amenities such as a fitness center and a seasonal outdoor pool.
Grab a bite to eat at the motel's restaurant, which features a bar, or stay in and take advantage of room service (during limited hours). Quench your thirst with your favorite drink at a bar/lounge.
Free self parking is available onsite.
Information missing or incorrect? Tell us!Hotel Amenities
Hotel Amenities
Brisbane International Windsor features a fitness center and a seasonal outdoor pool. The motel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink.
This Windsor motel also offers tour/ticket assistance and room service (during limited hours). Complimentary self parking is available on site.
Brisbane International Windsor is a smoke-free property.
- Tours/ticket assistance
- Total number of rooms - 61
- Bar/lounge
- Fitness facilities
- 24-hour front desk
- Number of floors - 3
- Restaurant
- Free self parking
- Smoke-free property
- Number of buildings/towers - 1
- Outdoor seasonal pool
Available in all rooms: Free wired high-speed Internet
Free self parking
Room Amenities
- Daily housekeeping
- Phone
- Private bathroom
- Complimentary toiletries
- Iron/ironing board
- Air conditioning
- Room service (limited hours)
- Desk
- Climate control
- Rollaway/extra beds available
- Digital TV service
- Flat-panel TV
- Free wired high-speed Internet
- Connecting/adjoining rooms available
- Cribs/infant beds (surcharge)
- Minibar
- Coffee/tea maker
- Hair dryer
Where to Eat
Va Bene Ristorante - This restaurant specializes in Italian cuisine and serves breakfast and dinner. Guests can enjoy drinks at the bar. Open select days.
Room service (during limited hours) is available.
Nearby Things to Do
Recreational amenities at the motel include a fitness center and a seasonal outdoor pool.
Guests under 16 years old are not allowed in the fitness facility.
Hotel Policies
Check-in time starts at 2 PM
Check-out time is 10 AM
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You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Crib (infant bed) fee: AUD 15.00 per night
- Rollaway bed fee: AUD 30 per night
- Onsite credit card charges are subject to a surcharge
We should mention
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
National Rating
Official Australia STAR Rating provided by AAA Tourism Pty Ltd
AAA Tourism Pty Ltd assigns an official STAR Rating for accommodations in Australia. This Motel property is rated 4 stars.


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Thu, Jul 31, 14 at 23:29
Follow-Up Postings:
- Posted by josephines67 5 ON (My Page) on Thu, Jul 31, 14 at 23:42
You sure have some premium hosta there, Mbug! Wow! Can't get over the size of some of them. Stag's Leap lept out at me! Love it for the elongated pointed end of beautiful leaf. Don't have any...am going googling for mature pics of your new babies/ teenagers, lol. |
- Posted by Don_in_Colorado 6a (My Page) on Fri, Aug 1, 14 at 4:48
What a bunch of cool plants, mbug...and now I'm hungry, too... Don B. |
- Posted by newhostalady 6 (My Page) on Fri, Aug 1, 14 at 9:34
Wow, that's a lot of new gorgeous hostas! Lucky you! |
- Posted by ThistleAndMaize Zone 5a- Eastern IA (My Page) on Fri, Aug 1, 14 at 12:05
I just received my Naylor auction hostas this week and I couldn't be happier. You definitely received some nice ones! (this makes me want to look at the auction list again...so tempting) |
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