text:
Publications (41)156.76 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: Introduction Les désordres métaboliques comme le diabète, l'obésité et le syndrome métabolique sont des préoccupations majeures de santé publique. Malgré sa contribution à l'homéostasie énergétique par sa fonction d'absorption des nutriments, l'intestin a reçu peu d'attention concernant son rôle potentiel dans ces pathologies comparé au foie, muscles et tissu adipeux. Deux formes du récepteur nucléaire HNF-4, alpha et gamma, sont fortement exprimés dans l'épithélium intestinal. Nous avons démontré précédemment que HNF-4alpha contrôle l'homéostasie de l'épithélium intestinal et l'absorption des lipides alimentaires par l'intestin. Contrairement à la forme alpha, HNF-4gamma a été peu étudié. Notre objectif est de déterminer son rôle physiologique. Matériels et méthodes Nous avons utilisé un modèle murin d'invalidation totale et constitutive de HNF-4gamma présentant un gain de poids significatif dès 4 mois suggérant une perturbation métabolique. Résultats La perte d'expression de HNF-4gamma entraîne une augmentation de la tolérance au glucose et une hyperinsulinémie lors d'un test oral au glucose mais pas lors d'un test intrapéritonéal, démontrant la part intestinale du phénotype observé. Grâce à un antagoniste du GLP-1, l'exendine 9, nous avons montré que le GLP-1, une entérohormone incrétine, est directement impliquée dans cet effet. De plus, l'invalidation de HNF-4gamma entraîne une augmentation du nombre de cellules exprimant le GLP-1 dans le jéjunum et le côlon (×1,7) ainsi que la quantité plasmatique basal et en réponse au glucose de GLP-1. L'analyse morphologique du pancréas et fonctionnelle sur îlots de Langherans isolés montre que la perte d'expression de HNF-4gamma entraîne une augmentation du nombre d'îlots moyens et larges (respectivement ×1,5 et ×1,8) ainsi que de leurs contenus en insuline (×1,7) sans que leurs capacités sécrétoires soit affectées. Conclusion Nous démontrons pour la première fois un rôle spécifique de HNF-4gamma dans le contrôle de l'homéostasie glucidique soulignant l'implication de l'intestin dans le contrôle de la balance énergétique.Diabetes & Metabolism 03/2014; 40:A4. · 2.85 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Enterocytes, the intestinal absorptive cells, have to deal with massive alimentary lipids upon food consumption. They orchestrate complex lipid trafficking events that lead to the secretion of triglyceride-rich lipoproteins and/or the intracellular transient storage of lipids as lipid droplets (LDs). LDs originate from the endoplasmic reticulum (ER) membrane and are mainly composed of a triglyceride (TG) and cholesterol-ester core surrounded by a phospholipid and cholesterol monolayer and specific coat proteins. The pivotal role of LDs in cellular lipid homeostasis is clearly established but processes regulating LD dynamics in enterocytes are poorly decrypted. Here we show that delivery of alimentary lipid micelles to polarized human enterocytes induces an immediate autophagic response, accompanied by phosphatidylinositol-3-phosphate appearance at the ER membrane. We observed a specific and rapid capture of newly synthesized LD at the ER membrane by nascent autophagosomal structures. By combining pharmacological and genetic approaches, we demonstrate that autophagy is a key player in TG targeting to lysosomes. Our results highlight the yet unraveled role of autophagy in the regulation of TG distribution, trafficking and turnover in human enterocytes.Molecular biology of the cell 10/2013; · 5.98 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Rationale: Signal initiation by the HDL receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain (CTTM). The CTTM uniquely interacts with plasma membrane (PM) cholesterol. Objective: The molecular basis and functional significance of SR-BI interaction with plasma membrane cholesterol are unknown. We tested the hypotheses that the interaction is required for SR-BI signaling, and that it enables SR-BI to serve as a plasma membrane cholesterol sensor. Methods and Results: In studies performed in COS-M6 cells, mutation of a highly-conserved CTTM glutamine to alanine (SR-BI-Q445A) decreased PM cholesterol interaction with the receptor by 71% without altering HDL binding or cholesterol uptake or efflux, and it yielded a receptor incapable of HDL-induced signaling. Signaling prompted by cholesterol efflux to methyl-β-cyclodextrin (CD) was also prevented, indicating that PM cholesterol interaction with the receptor enables it to serve as a PM cholesterol sensor. Using SR-BI-Q445A, we further demonstrated that PM cholesterol sensing by SR-BI does not influence SR-BI-mediated reverse cholesterol transport to the liver in mice. However, the PM cholesterol sensing does underlie apolipoprotein B intracellular trafficking in response to postprandial micelles or CD in cultured enterocytes, and it is required for HDL activation of eNOS and migration in cultured endothelial cells and HDL-induced angiogenesis in vivo. Conclusions: Through interaction with plasma membrane cholesterol, SR-BI serves a PM cholesterol sensor, and the resulting intracellular signaling governs processes in both enterocytes and endothelial cells.Circulation Research 09/2012; · 11.09 Impact Factor -
Article: The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
[Show abstract] [Hide abstract]
ABSTRACT: With an excessive postprandial accumulation of intestine-derived, triglyceride-rich lipoproteins being a risk factor of cardiovascular diseases, it is essential to characterize the mechanisms controlling the intestinal absorption of dietary lipids. Our aim was to investigate the role of the transcription factor hepatocyte nuclear factor (HNF)-4α in this process. We used transgenic mice with a specific and inducible intestinal knockout of Hnf-4α gene. One hour after a lipid bolus, in the presence of the lipase inhibitor tyloxapol, lower amounts of triglycerides were found in both plasma and intestinal epithelium of the intestine-specific Hnf-4α knockout (Hnf-4α(intΔ)) mice compared with the Hnf-4α(loxP/loxP) control mice. These discrepancies were due to a net decrease of the intestinal uptake of fatty acid in Hnf-4α(intΔ) mice compared with Hnf-4α(loxP/loxP) mice, as assessed by the amount of radioactivity that was recovered in intestine and plasma after gavage with labeled triolein or oleic acid, or in intestinal epithelial cells isolated from jejunum after a supply of labeled oleic acid-containing micelles. This decreased fatty acid uptake was associated with significant lower levels of the fatty acid transport protein-4 mRNA and protein along the intestinal tract and with a lower acyl-CoA synthetase activity in Hnf-4α(intΔ) mice compared with the control mice. We conclude that the transcription factor HNF-4α is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.AJP Gastrointestinal and Liver Physiology 03/2012; 302(11):G1253-63. · 3.65 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: As arginine plays a key role in the regulation of liver ureagenesis, we hypothesised that a modulation of enzymes involved in arginine metabolism within the intestine contributes to the regulation of N homeostasis according to protein supply. Our aim was to study the influence of variations in protein or amino acid (AA) supply on intestinal arginase, glutaminase, ornithine aminotransferase (OAT), argininosuccinate lyase and argininosuccinate synthetase. We evaluated in vivo in rats the responses of these enzymes to short-term (ST, 16 h) and long-term (LT, 15 d) variations in dietary protein (10, 17 or 25 % protein diet). In addition, in order to test whether these responses could involve a direct action of AA on the gene expression and activity of these enzymes, Caco-2/TC7 cells were cultured for 3 d with increasing AA concentrations. In vivo, in the ST, both high- and low-protein diets increased arginase activity in the intestinal mucosa (ST25 %: 46 (sem 2) μmol/g per min and ST10 %: 46 (sem 2) μmol/g per min v. ST17 %: 36 (sem 3) μmol/g per min, P < 0.05). In the LT, OAT expression was increased in the LT10 % group (+277 %, P < 0.05) compared with the LT17 % group. Caco-2/TC7 cells showed inverse relationships between AA supply and arginase (P = 0.058) and OAT (P = 0.035) expressions. The present study demonstrates the regulation of intestinal arginase and OAT expressions in response to protein supply. Our in vitro experiments further indicate a direct AA-induced regulation of the mRNA abundance of these enzymes. In situations of limited protein supply, this regulation would increase intestinal arginine catabolism and, possibly via a decrease in arginine portal release, decrease hepatic AA oxidation, thus promoting N sparing.The British journal of nutrition 07/2011; 106(2):227-36. · 3.45 Impact Factor -
Article: 443 THE TRANSCRIPTION FACTOR HNF-4α: A KEY ACTOR OF THE INTESTINAL UPTAKE OF FATTY ACIDS IN MOUSE
Atherosclerosis Supplements 06/2011; 12(1):94-94. · 9.67 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The intestine is responsible for absorbing dietary lipids and delivering them to the organism as triglyceride-rich lipoproteins (TRL). It is important to determine how this process is regulated in enterocytes, the absorptive cells of the intestine, as prolonged postprandial hypertriglyceridemia is a known risk factor for atherosclerosis. During the postprandial period, dietary lipids, mostly triglycerides (TG) hydrolyzed by pancreatic enzymes, are combined with bile products and reach the apical membrane of enterocytes as postprandial micelles (PPM). Our aim was to determine whether these micelles induce, in enterocytes, specific early cell signaling events that could control the processes leading to TRL secretion. The effects of supplying PPM to the apex of Caco-2/TC7 enterocytes were analyzed. Micelles devoid of TG hydrolysis products, like those present in the intestinal lumen in the interprandial period, were used as controls. The apical delivery of PPM specifically induced a number of cellular events that are not induced by interprandial micelles. These early events included the trafficking of apolipoprotein B, a structural component of TRL, from apical towards secretory domains, and the rapid, dose-dependent activation of ERK and p38MAPK. PPM supply induced the scavenger receptor SR-BI/CLA-1 to cluster at the apical brush border membrane and to move from non-raft to raft domains. Competition, inhibition or knockdown of SR-BI/CLA-1 impaired the PPM-dependent apoB trafficking and ERK activation. These results are the first evidence that enterocytes specifically sense postprandial dietary lipid-containing micelles. SR-BI/CLA-1 is involved in this process and could be a target for further study with a view to modifying intestinal TRL secretion early in the control pathway.PLoS ONE 02/2009; 4(1):e4278. · 3.53 Impact Factor - PLoS ONE 01/2009; 4(1). · 3.53 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Intestine contributes to lipid homeostasis through the absorption of dietary lipids, which reach the apical pole of enterocytes as micelles. The present study aimed to identify the specific impact of these dietary lipid-containing micelles on gene expression in enterocytes. We analyzed, by microarray, the modulation of gene expression in Caco-2/TC7 cells in response to different lipid supply conditions that reproduced either the permanent presence of albumin-bound lipids at the basal pole of enterocytes or the physiological delivery, at the apical pole, of lipid micelles, which differ in their composition during the interprandial (IPM) or the postprandial (PPM) state. These different conditions led to distinct gene expression profiles. We observed that, contrary to lipids supplied at the basal pole, apical lipid micelles modulated a large number of genes. Moreover, compared with the apical supply of IPM, PPM specifically impacted 46 genes from three major cell function categories: signal transduction, lipid metabolism, and cell adhesion/architecture. Results from this first large-scale analysis underline the importance of the mode and polarity of lipid delivery on enterocyte gene expression. They demonstrate specific and coordinated transcriptional effects of dietary lipid-containing micelles that could impact the structure and polarization of enterocytes and their functions in nutrient transfer.AJP Gastrointestinal and Liver Physiology 09/2008; 295(5):G942-52. · 3.74 Impact Factor - Clinical Nutrition Supplements 01/2008; 3:199-200.
- [Show abstract] [Hide abstract]
ABSTRACT: Introduction et but de l'étude Le flux portal d'Arginine (Arg) est un élément clé de la régulation de l'uréogenèse hépatique. L'intestin est l'organe qui contrôle la disponibilité de l'Arg apportée par voie digestive. Cela dépendrait d'une modulation de l'expression de différentes enzymes (arginase, glutaminase, ornithine ami-notransférase (OAT) et argininosuccinate lyase (ASL) et synthétase (ASS)) par les apports en protéines de la ration alimentaire. Le but de ce travail a été d'étudier l'influence d'apports croissants en acides aminés (AA) sur l'expression de ces enzymes dans un modèle de cellules intestinales, les cellules Caco-2/TC7. Matériel et méthodes Des cellules Caco-2/TC7 ont été cultivées sur filtre semi-perméable pendant 15 jours en milieu standard puis ont été réparties en 4 groupes (n=3). Les cellules ont alors été exposées pendant 3 jours à différents milieux dépourvu d'AA (0), ou contenant des concentrations croissantes en AA, correspondant à une (1X), deux (2X) et quatre (4X) fois les concentrations physiologiques plasmatiques post-prandiales. Les ARNm codant pour les enzymes d'intérêt ont été quantifiés par PCR en temps réel. Les résultats ont été analysés par régression linéaire (test de Student sur la pente). Résultats Il existe une relation inverse entre les apports en AA et l'expression de la glutaminase (p= 0,028), de l'OAT (p= 0,035), de l'ASS (p= 0,028) et de l'arginase (p= 0,058). Conclusions Cette étude montre pour la première fois un effet direct des AA sur la régulation au niveau transcriptionnel des enzymes du carrefour intestinal de l'arginine en fonction de l'apport Tableau 1Les niveaux d'expression des différentes enzymes, rapportées à la quantité d'ARNr 18SView Within Article azoté. Cette régulation permettrait ainsi, dans des situations de faibles apports azotés, de favoriser la synthèse intestinale de citrulline et par conséquent la néosynthèse rénale d'Arg. Lors d'apports azotés plus importants, cela favoriserait le passage de l'Arg absorbée dans le système porte et donc une stimulation adaptée de l'uréoge-nèse hépatique.Nutrition Clinique et Métabolisme 11/2007; 21:53-54. · 0.62 Impact Factor - Gastroentérologie Clinique et Biologique 05/2006; 30(5):702-702. · 1.14 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Glucose-6-phosphatase (G6Pase) catalyzes the release of glucose from glucose 6-phosphate. This enzyme was mainly studied in the liver, but while detected in the small intestine little is known about the regulation of its intestinal expression. This study describes the mechanisms of the glucose-dependent regulation of G6Pase expression in intestinal cells. Results obtained in vivo and in Caco-2/TC7 enterocytes showed that glucose increases the G6Pase mRNA level. In Caco-2/TC7 cells, glucose stabilized G6Pase mRNA and activated the transcription of the gene, meaning that glucose-dependent G6Pase expression involved both transcriptional and post-transcriptional mechanisms. Reporter-gene studies showed that, although the -299/+57 region of the human G6Pase promoter was sufficient to trigger the glucose response in the hepatoma cell line HepG2, the -1157/-1133 fragment was required for maximal activation of glucose-6-phosphatase gene transcription in Caco-2/TC7 cells. This fragment binds the aryl receptor nuclear translocator (ARNT), cAMP-responsive element-binding protein, and upstream stimulatory factor transcription factors. The DNA binding activity of these transcription factors was increased in nuclear extracts of differentiated cells from the intestinal villus of mice fed sugar-rich diets as compared with mice fed a no-sugar diet. A direct implication of ARNT in the activation of G6Pase gene transcription by glucose has been observed in Caco-2/TC7 cells using RNA interference experiments. These results support a physiological role for G6Pase in the control of nutrient absorption in the small intestine.Journal of Biological Chemistry 06/2005; 280(20):20094-101. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Apolipoprotein (apo) A-IV, a component of triglyceride-rich lipoproteins secreted by the small intestine, has been shown to play an important role in the control of lipid homeostasis. Numerous studies have described the induction of apoA-IV gene expression by lipids, but the molecular mechanisms involved in this process remain unknown. In this study, we have demonstrated that a lipid bolus induced transcription of the apoA-IV gene in transgenic mice and that the regulatory region of the apoA-IV gene, composed of the apoC-III enhancer and the apoA-IV promoter (eC3-A4), was responsible for this induction. In enterocyte Caco-2/TC7 cells, a permanent supply of lipids at the basal pole induced expression of the apoA-IV gene both at the transcriptional level and through mRNA stabilization. ApoA-IV gene transcription and protein secretion were further induced by an apical supply of complex lipid micelles mimicking the composition of duodenal micelles, and this effect was not reproduced by apical delivery of different combinations of micelle components. Only induction of the apoA-IV gene by lipid micelles involved the participation of hepatic nuclear factor (HNF)-4, as demonstrated using a dominant negative form of this transcription factor. Accordingly, lipid micelles increased the DNA binding activity of HNF-4 on the eC3-A4 region. These results emphasize the importance of physiological delivery of dietary lipids on apoA-IV gene expression and the implication of HNF-4 in this regulation.Journal of Biological Chemistry 03/2005; 280(7):5406-13. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Aminopeptidase B (Ap-B), a ubiquitous enzyme, catalyses the amino-terminal cleavage of basic residues of peptide or protein substrates, indicating a role in precursor processing. The physiological function of Ap-B still remains an open question, even though its activity suggests that it could be involved in inflammatory processes and proliferation of tumor cells. This study was conducted to determine the expression of Ap-B in the developing and adult retina as a path to envisage physiological roles of Ap-B. RT-PCR and in situ hybridization were used to detect expression of Ap-B mRNA and activity tests, Western blotting and immunofluorescence microscopy were performed to identify and localize the enzyme in the rat retina. These biochemical and morphological methods show that Ap-B is expressed in the retina from embryo to adult. Expression level is restricted to specific layers (pigmented epithelium, outer and inner plexiform layers and ganglion cell layer) and is developmentally regulated. Moreover, a preliminary analysis indicates that Ap-B, the glucose transporter GLUT3 and choline acetyltransferase (ChAT) share a similar expression pattern in retina. Altogether, Ap-B appears predominantly expressed in neuronal cells lying in retinal layers containing neuritic extensions and synaptic junctions. Such expression is up-regulated during ontogenesis allowing to hypothesized that Ap-B participates in processes accompanying retinal neuronal cell differentiation.Experimental Eye Research 12/2004; 79(5):639-48. · 3.02 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The physiological significance of the presence of GLUT2 at the food-facing pole of intestinal cells is addressed by a study of fructose absorption in GLUT2-null and control mice submitted to different sugar diets. Confocal microscopy localization, protein and mRNA abundance, as well as tissue and membrane vesicle uptakes of fructose were assayed. GLUT2 was located in the basolateral membrane of mice fed a meal devoid of sugar or containing complex carbohydrates. In addition, the ingestion of a simple sugar meal promoted the massive recruitment of GLUT2 to the food-facing membrane. Fructose uptake in brush-border membrane vesicles from GLUT2-null mice was half that of wild-type mice and was similar to the cytochalasin B-insensitive component, i.e. GLUT5-mediated uptake. A 5 day consumption of sugar-rich diets increased fructose uptake fivefold in wild-type tissue rings when it only doubled in GLUT2-null tissue. GLUT5 was estimated to contribute to 100 % of total uptake in wild-type mice fed low-sugar diets, falling to 60 and 40 % with glucose and fructose diets respectively; the complement was ensured by GLUT2 activity. The results indicate that basal sugar uptake is mediated by the resident food-facing SGLT1 and GLUT5 transporters, whose mRNA abundances double in long-term dietary adaptation. We also observe that a large improvement of intestinal absorption is promoted by the transient recruitment of food-facing GLUT2, induced by the ingestion of a simple-sugar meal. Thus, GLUT2 and GLUT5 could exert complementary roles in adapting the absorption capacity of the intestine to occasional or repeated loads of dietary sugars.The Journal of Physiology 12/2003; 552(Pt 3):823-32. · 4.54 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Chlorzoxazone, a centrally acting muscle relaxant, was previously shown to be hydroxylated on carbon 6 specifically by cytochrome P450 2E1. Accordingly, this drug has been proposed as a potential noninvasive in-vivo probe for screening the hepatic P450 2E1 activity. This study was carried out to test the specificity of such a substrate when first experiments conducted by using human hepatocyte cultures showed that the chlorzoxazone 6-hydroxylation activity increased after 3-methylcholanthrene treatment of cells. Indeed, the ability of both rat and human hepatocytes to metabolize chlorzoxazone significantly increased after treatments by 3-methylcholanthrene alone or plus ethanol, suggesting the involvement of P450 1A enzymes in this oxidative reaction. Identical results were obtained by in-vivo treatment of rats with four inducers of P450 1A enzymes, namely, beta-naphthoflavone, isosafrole, Arochlor 1254, and 3-methylcholanthrene. Furthermore, the chlorzoxazone 6-hydroxylation activity was inhibited by both alpha-naphthoflavone and dimethyl sulfoxide, both known to inhibit P450 1A and P450 2E1 activities, respectively. Finally, the use of yeasts genetically engineered for expression of human P450 1A1, 1A2, 2C9, and 3A4 demonstrated that P450 1A1 was significantly involved in this catalytic activity. In conclusion, these results taken together suggest that chlorzoxazone should be used with precaution as in-vivo tool for evaluating P450 2E1. However, the relative Km of P450 1A1 and 2E1 for chlorzoxazone and, on the other hand, the relative levels of these two enzymes in the human liver suggest that P450 2E1 would generally be the major form metabolizing chlorzoxazone in-vivo.Chemical Research in Toxicology 04/2002; 6(6):852-7. · 4.19 Impact Factor - 12/2001: pages 15-21;
Article: Intestinal responses to xenobiotics.
[Show abstract] [Hide abstract]
ABSTRACT: The gastrointestinal tract represents the first barrier met by the exogenous compounds of food or orally delivered drugs. To be transferred to the whole body, drugs and xenobiotics have first to pass through the intestinal epithelium, where detoxification systems have to minimize the potential of damage from toxic xenobiotics. However, most studies on xenobiotic-metabolizing enzymes have focused on liver enzymes. Such a situation may be explained by the fact that this organ is the site of toxification/detoxification for both endogenous and exogenous compounds, and also because adequate in vitro hepatocytes models have been available for a long time. By contrast, normal cellular models for the in vitro study of the intestinal processes of biotransformation still remain difficult to obtain. In the present report we will thus focus on the most commonly used models, which are Caco-2 cells and their derivative clones, and we will report recent procedures that allow the isolation of normal enterocytes which maintain their functions and integrity for several hours or even several days. Their respective performance and advantages for the study of the induction of the drug-metabolizing enzymes will be discussed.Toxicology in Vitro 08/2001; 15(4-5):373-8. · 3.21 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Phosphorylation/dephosphorylation processes are known to control the activity of several transcription factors. The nutrition-dependent expression of sucrase-isomaltase and Na+/glucose co-transporter 1, two proteins implicated in the intestinal absorption of glucose, has been shown to be closely related to modifications of hepatocyte nuclear factor 1 (HNF1) activity. This study was conducted to determine whether phosphorylation/dephosphorylation processes could control HNF1 activity. We show that expression of the gene encoding sucrase-isomaltase is inhibited in the enterocytic Caco-2 clone TC7 by okadaic acid at a concentration that is known to inhibit protein phosphatases 1/2A and that does not affect cell viability. At the same concentration, phosphorylation of the HNF1alpha and HNF1beta isoforms is greatly enhanced and their DNA-binding capacity is decreased. The phosphorylation state of HNF1beta isoforms directly affects their DNA-binding capacity. In contrast, the decreased DNA-binding activity of the HNF1alpha isoforms, which was observed after the inhibition of protein phosphatases 1/2A, is due to a net decrease in their total cellular and nuclear amounts. Such an effect results from a decrease in both the HNF1alpha mRNA levels and the half-life of the protein. This is the first evidence for the implication of protein phosphatases 1/2A in the control of the activity of HNF1 isoforms. Moreover, these results emphasize a physiological role for the balance between phosphatases and kinases in the nutrition-dependent regulation of HNF1-controlled genes.Biochemical Journal 04/2001; 354(Pt 2):301-8. · 4.78 Impact Factor
Publication Stats
611 | Citations | |
156.76 | Total Impact Points | |
Top Journals
Pierre and Marie Curie University - Paris 6
- Centre de recherche des Cordeliers - UMR_S 872
Paris, Ile-de-France, France
Institut des Systèmes Complexes, Paris Île-de-France
Lutetia Parisorum, Île-de-France, France
Pittsburgh, Pennsylvania, United States
French National Centre for Scientific Research
- Centre de Biophysique Moléculaire
Paris, Ile-de-France, France
French Institute of Health and Medical Research
Lutetia Parisorum, Île-de-France, France -
Université René Descartes - Paris 5
Lutetia Parisorum, Île-de-France, France


text:
Counselors in Denver
Denver counselors are trained to help residents handle any crisis, from family issues to marital problems that may require the intervention of a professional. Counselors are available through most health insurance programs and specialize in different areas depending upon the needs of the client. Denver counselors can also make referrals to clients should be they in need of more specialized or medical care.
Denver Hotel Deals
Best Western Inn & Suites Of Castle Rock
Castle Rock, CO
Avg per night
Popular Businesses
The Healing Chakra
750 East 9th Avenue #107
Quiet River Addiction Center
2500 Arapahoe St
Essence Ayurveda & Yoga Therapy
122 Garfield Street
Encompass Counseling, Llc
190 East 9th Avenue, Suite 350
Jeffco Addiction Assessment Clinic (jaac)
7475 W. 5th Ave., #150 D
Top Stories
Denver Counselors by Neighborhood
View AllPopular Neighborhoods
© 2015 Denver.com: A City Guide by Boulevards. All Rights Reserved. Advertise with us | Contact us | Privacy Policy | Terms of Use | Site Map

subset: commoncrawl


text:
Sue Bird
Storm look for new coach after Agler leaves for Sparks
there.'' He said he'll miss his players and it was tough telling them of his move. ''It was difficult telling Sue ( Bird ) and Lauren ... as they've been part of the foundation since I've been there,'' Agler said. ''But also I'm
Bird scores 22 as Storm beat Shock 74-68
SEATTLE (AP) Sue Bird scored 22 points and Camille Little added 16 to help the Seattle Storm ..... second-half deficit and beat the Tulsa Shock 74-68 on Sunday night. Bird , who scored 10 in the fourth quarter, hit four 3s as Seattle (12-20
UConn's Geno Auriemma not close to retirement
hasn't changed much since the first day I met him,'' said Sue Bird , who starred at UConn in the early 2000s and then played ..... It's the same method he used with Rebecca Lobo, Bird , Diana Taurasi, Tina Charles, Maya Moore and now Stewart
Bird , Langhorne lead Storm past Sky, 80-73
SEATTLE (AP) Sue Bird scored eight straight points late in the ..... Chicago Sky 80-73 on Saturday night. Bird and Crystal Langhorne each scored 19 points ..... death in her family, added 18 points. Bird 's scoring run included a 20-footer
Bird and Latta named WNBA All-Star replacements
NEW YORK (AP) Sue Bird and Ivory Latta have been selected as replacements ..... game by WNBA President Laurel J. Richie. Bird , who stars for Seattle, will join the ..... participating in the All-Star game. Bird will be making her eighth All-Star appearance
US and Spain to meet for gold at women's worlds
semifinals and the U.S. came away with a 36-point win. Sue Bird expects a different team to show up on Sunday. ''They're ..... thrive on emotion, screaming Vamos after every score,'' Bird said. ''When they've got it going, they really get
US women rout Angola 119-44, finish pool play 3-0
surpassing the 70-point win over Senegal in 1990. Point guard Sue Bird set her own mark, playing in a U.S. record 28th world ..... Tamika Catchings, Katie Smith and Delisha Milton-Jones. Bird is playing in a team-record fourth worlds. African teams
Mercury-Storm Preview
tip-off of Friday's 77-65 loss to Los Angeles. Starters Sue Bird , Camille Little and Tanisha Wright played a total of 14 ..... for our fans, and for each other.'' It seems likely Bird , Little and Wright will play bigger minutes on Fan Appreciation
Langhorne lifts Storm to 71-65 win over Stars
Antonio Stars on Sunday night. Langhorne scored seven and Sue Bird added five in the final three minutes of the game after ..... also had 10 rebounds. Camille Little added 15 points and Bird 10 for Seattle (10-20), which moved within 3 1/2
Women's hoops players undeterred by George injury
really long time that hasn't been the scenario,'' said Sue Bird , who has won three Olympic gold medals for the U.S ..... represent your country. It always was the end game.'' Bird went on to say that even if that scenario did exist she


text:
StartUpHire is the place to find Senior Graphic Designer jobs. Review the list of Senior Graphic Designer career opportunities to the left. These Senior Graphic Designer jobs represent some of the most rewarding careers available.
You can refine your job search for Senior Graphic Designer career opportunities by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options.
Don't see the employment opportunity you're looking for? Check back soon for more Senior Graphic Designer jobs, or sign up for an email alert (link below) to receive periodic updates on new Senior Graphic Designer jobs.
The Job The Senior Graphic Designer is responsible for creating beautiful and compelling digital marketing that helps to elevate the brand and seasonal campaigns online. This position focuses on building a seamless e-commerce experience that exudes the Tea story and personality.
1/7/2015 San Francisco, CA Save This JobMoki is looking for a self-motivated and driven Senior Graphic Designer interested in working in a fast growing technology company. Moki is located in a prime business complex at Thanksgiving Point equally convenient for Utah and Salt Lake County residence. Moki has a great
1/12/2015 Lehi, UT Save This JobAtTask is looking for an enthusiastic UI/graphic designer with 3-5 years experience designing web application and mobile interfaces. The ideal candidate is professional, detail-oriented, comfortable working independently, and familiar with building styleguides, icons, and
12/29/2014 Lehi, UT Save This JobWeb & Graphic Designer Aras is a fast growing, rapidly expanding global start-up that provides advanced Product Lifecycle Management (PLM) software solutions to business customers worldwide, including Motorola, XEROX, Honda, GE, Kawasaki and more. Learn more at www.aras.com and
12/31/2014 Andover, MA Save This Job1160, Battery Street, 4th Floor, San Francisco, California, 94111 Here at Mindjet we have a great opportunity for a full time permanent Senior Web Designer to join a fast growing, industry leading, driven, and committed company. Not forgetting to mention be part of the exciting
1/9/2015 San Francisco, CA Save This Job1160, Battery Street, 4th Floor, San Francisco, California, 94111 Here at Mindjet we have a great opportunity for a full time permanent Senior Web Designer to join a fast growing, industry leading, driven, and committed company. Not forgetting to mention be part of the exciting
1/9/2015 Cincinnati, OH Save This JobMore information about this job: What We're Looking For: The graphic designer will work closely with the brand marketing team, senior art director and copywriters to develop designs for marketing programs and plans for 2U?s partners. Key Responsibilities (include but are not
12/30/2014 Landover, MD Save This JobResponsibilities Research and understand the various complexities of our data and develop our user personas. Work with the Product & Client Services teams to clarify and define design requirements and user stories. Work with Director of User Experience & design team to design
1/29/2015 New York, NY Save This JobPosition Summary As Senior Lead Designer, you are a leader that inspires your colleagues to think bigger. You will have primary responsibility for execution of design projects across three key customer segments, ensuring consistency of the Blurb brand while developing
12/26/2014 San Francisco, CA Save This JobWe are currently seeking a Senior Visual Designer for contract and full-time opportunities to join our Philadelphia area team of professionals. Working under the supervision of the Creative Director, Senior Designers are responsible for look & feel exploration, conceptual and
12/8/2014 Conshohocken, PA Save This JobSpace Exploration TechnologiesWork to advance the course of human history and pave the way to Mars.SpaceX is a US based advanced technology company founded by residing CEO and CTO, Elon Musk. SpaceX builds rockets and spacecraft from the ground up including cutting edge
1/17/2015 Hawthorne, CA Save This JobThe Senior Interactive Designer will play a key role in designing and producing interactive video and mobile advertisements. The applicant must have a solid understanding of Flash animation including intermediate/advanced ActionScript, Photoshop, general mobile and web related
12/3/2014 Santa Monica, CA Save This JobSprout Social provides social media engagement, publishing and analytic tools for leading brands including GrubHub, Spotify, Urban Outfitters and Zipcar.
11/24/2014 Chicago, IL Save This JobAlkami is looking for a talented graphic designer who will be responsible for developing and preserving the company brand and translating it to a wide variety of marketing materials for web and print. Flexibility, attention to detail, the ability to learn quickly and communicate
11/26/2014 Plano, TX Save This JobWhat you?ll do As a Senior Designer, you will be responsible for partnering with the creative team and executing conceptual marketing driven projects that support the Belkin brand. These projects require a complete understanding of all visual communications including typography,
12/1/2014 Los Angeles, CA Save This Jobat Houzz Palo Alto Upgrade your career at one of the hottest startups in Silicon Valley! If you are great at what you do, thrive in a highly collaborative environment, and don?t mind the occasional meeting in the bathroom (don?t worry, it?s just one of our conference rooms), we
12/3/2014 Palo Alto, CA Save This JobHow often do you actually get to merge your creative bone with a day job? Rarely. But that's exactly what we expect out of our Associate Graphic Designer. You'll be joining the talented S6 creative team as visual support. Off the top of our head that could include asset
1/16/2015 Santa Monica, CA Save This JobWe are currently seeking an experienced Senior User Interface Designer with proven strong graphic and illustrative design skills, who can think broadly while executing with pixel-level eye for detail. In this role you will work in close partnership with product management,
1/26/2015 San Francisco, CA Save This JobWe are currently seeking an experienced Senior User Interface Designer with proven strong graphic and illustrative design skills, who can think broadly while executing with pixel-level eye for detail. In this role you will work in close partnership with product management,
1/19/2015 San Francisco, CA Save This JobStyleCaster Media Group is the media and advertising technology company for people that have a passion for style and culture. This disruptive digital media company empowers style enthusiasts and the brands that want to reach them. StyleCaster combines the art of traditional media
12/7/2014 New York, NY Save This Job


text:
Click on more info to Add to bag and more
You are shopping on behalf of a Guest Customer
You have enacted a Registered Customer's account
ORDER BY 7pm for next day delivery ORDER by 10pm for next evening delivery
£81.67 per 100ml
Item No.1230720613
Clinique's New Even Better Foundation SPF15 oil free formula, a powerful foundation developed to deliver brighter skin. Helps even skin tone and SPF protection to help prevent future uneven skin tone. Provides moderate to full coverage, leaving skin instantly perfected with a unique mineral blend.
UK Home Delivery Free (UK orders over £30) or £3.99
Delivered within 4 working days
Next or Named Day Delivery
7 days a week between 8am - 6pm
Monday to Friday - order by 7pm - £4.99
Saturday & Sunday - order by 6pm - £4.99
Next or Named Evening Delivery
7 days a week between 6pm - 10pm
Monday to Sunday - order by 10pm - £6.99
Collect from store the next day - FREE
Order before 7pm for next day collection after 12pm midday
Show participating stores
Show countries and charges
Full Delivery details


text:
About Us
A pioneer in the South African online news space, Indie Does It is a one-stop shop for your very best music news, gossip, entertainment and commentary. Indie Does It offers a space for music enthusiasts to engage, share and learn about South Africa and its ever-progressing music industry.
5FM Love Sucks! – Anti-Valentine's Hoop Up
"Love is a grave mental disease" – Plato, Philosopher For the last four years, 5FM have hosted their anti-Valentine's day party. Come 2015 and they plan to make it bigger…
Understanding Your Voice: RJ Benjamin Free Workshop
In conjunction with Music Exchange and Paul Bothner Music, the award-winning vocalist, songwriter, composer and producer from Johannesburg, RJ Benjamin will host a FREE vocal workshop in Cape Town come end…
Cook It, Snap It and Win – Photo Competition for Foodies
InstaCook is a new photographic competition launched by Pick n Pay and designed to inspire amateur chefs and home cooks to plate and photograph their food. Entrants are required to recreate…
2015 Oscar Nominations
Who do you think is going to lay their hands on the coveted Oscar statues? The 87th Academy Award Nominations for the 2015 Oscars are listed below. In your view,…
Concerts To Look Forward To In 2015
Over the past two years or so, South Africa has witnessed an increase in international artists touring the country. Gone are the days when people bought tickets to see an…
Fashion-Hero Search: Marvel Inspired Designs
I've always been a fan of out-of-the-box thinking. People who are not afraid to experiment, to try new things and in turn discover endless possibilities. One such conception is the…
Album Reviews
Howie Combrink – Eat It While It's Hot
After much anticipation, Howie Combrink has released his debut album, Eat It While It's Hot - after a year in the making. The drummer, turned songwriter, spent many of his years…
The Hanging Gardens of Beatenberg
Rating: This is a fantastic debut. Beatenberg have artfully integrated a variety of age old sounds and made them sound fresh. Distinctly African meets Top 40; they have devised the…
Shaun Jacobs – Love Can
Shaun Jacobs is no stranger to the music scene. After many years of performing and writing music, Love Can hit the airwaves and elevated him to prime status. He achieved…
Michael Lowman – Crayon Boxes
Six months since the release of first single Your Lovin' Ain't Right, Michael Lowman's debut album Crayon Boxes has finally arrived and it doesn't disappoint. The singer-songwriter who launched his…
Gangs Of Ballet – Yes/No/Grey
Any band with such artful titles for their songs – Can't Do This On My Own, Fool With A Heart – is bound to capture my attention from the get-go….
Guy Buttery – Live In Kwazulu
Described as a "one man guitar orchestra", Guy Buttery is the real deal. His fingerstyle guitar playing is intricate and precise. Proudly South African, Buttery is a little awkward on…
Gig Reviews
Peter Pan Pantomime: It's a Scentsation
Janice Honeyman's pantomimes have been a smash hit among Joburgers year on year. Many families have turned the theatre experience into a family tradition, returning each year with their aging…
Review: Branden James – Up Close And Personal
The great thing about seeing a classical crossover artist like Branden James in concert is that you never know what to expect. From the more operatic numbers like You Raise…
Review: Casting Crowns Live In SA
"We were made to more than just survive, we were made to thrive," sings lead singer and youth pastor Mark Hall of Casting Crowns. The Christian rock band visited South…
Review: Freckleface Strawberry – The Musical
South Africa has immense musical talent. The problem: often people don't know where to find them. But we do! The National Children's Theatre is bringing Freckleface Strawberry: The Musical to…
Review: Simple Minds Return To SA After 18 Years
The best thing about watching a band that's been going for 35 years straight is a guaranteed tight performance. Formed in Glasgow, Scotland in 1977, Simple Minds reached the height…
Review: Gangs Of Ballet Yes/No/Grey Album Launch
If you haven't heard of Gangs Of Ballet, then you must be hiding under a rock. Taking into consideration the crowd that showed up to their album launch, Gangs Of…


text:
Advisory sent by Northern Regional Load Dispatch Centre
The Northern Regional Load Dispatch Centre (NRLDC) wants all constituent States, including Delhi, to be prepared for fog that leads to tripping of power lines and guard against grid collapse. In an advisory sent to all States, the NRLDC has asked for strict adherence to the grid code and a ban on over-drawing of power that threatens the safety of the grid.
To ensure there is no rampant over-drawal of power and the frequency is maintained, the NRLDC has asked all states to ensure under frequency relays are installed and load shedding through these relays is adequate. All State load dispatch centres have been asked to maintain strict vigil on deviations.
"Delhi adheres to the grid code, it does not overdraw and does not allow the frequency to dip below the critical levels, but several other States don't follow the same practice, which results in grid being endangered. Past winter there were several instances of power cuts in Delhi on account of over drawal and power lines tripping, because of negligence," said an official of the Delhi's Government.
The NRLDC has asked States to ensure that insulators are cleaned up before fog descends and all planned shutdowns of transmissions lines are deferred and not carried out from December to February. To minimise problems during an unexpected breakdown, all States need to have a contingency plan, which includes alternate path for incoming and outgoing feeders in sub-stations. All generating stations have been told to monitor the power flow in transmission lines and directions have also been issued to keep tabs on voltage control related issues with special attention paid to maintaining voltage flow during the night hours when power consumptions dips.
Weather monitoring to help assess the power demand has been stressed on as well. States have been asked to use weather data for fog monitoring to avoid problems of insulators tripping on account of deposits and for making adequate power arrangements.
Keywords: Northern Regional Load Dispatch Centre, fog related problems, winter season, grid collapse, power issues


text:
Comfort Suites West Dallas - Cockrell Hill 4275 DFW Turnpike/IH-30 Dallas, TX 75211 Phone: (214) 267-0100 Fax: (214) 217-5194 |
»Downtown Carroltown
Dallas has plenty of big malls but sometimes those little intimate Mom and Pop shops can be sorely missed. For one of those reminiscent moments stop over at the Downtown Carrollton shopping area. This old downtown still stands as a block of old shops that have been occupied by independent craft and antique sellers.
»Bishop Art District
The Bishops Art District is a shopping paradise found in the middle of Oak Cliff. This artistic, inviting district is a collection of unique, independent shops, restaurants, and galleries. There's a lot to explore, so wear your walking shoes. Whether you're looking for something for your home, your pet, or your friends, you'll find one-of-a-kind items to fit your needs here.
»Bishop Street Market
Bishop Street Market is less of a traditional market and more of a unique artistic gift shop with one-of-a-kind items ranging from sculptures to soaps to the most creative gift cards in the city. If individual is your style then you will meet your match here. Voted "Best Gift Store" by such notable sources as "D" Magazine, The Dallas Morning News, and Texas Monthly, how can you pass by without a stop?
Located in the Bishops Art District, this unique gift shop is a blast to visit. It is most commonly visited for the handmade soaps and bath items from natural products around the work. However, it should be noted for the amazing candles and unique gift items. The prices are very reasonable, which can be difficult around this shopping center. A stop here will be one of fun and complete relaxation after smelling the different products that will surely put you in a natural state of mind.
»Collars 2 Cuffs
Boasting a 4,000-square-foot showroom space, this specialty shop is one of Dallas' best-kept secrets. With its professional, high-quality service and long list of designer fashions at discount prices, it's no wonder so many men have wanted to keep this little jewel all to themselves. Shoppers will find custom shirts, business attire, golf and casual wear, formal wear, shoes and much more.
»Cozy Cottage
This clothing store, at the end of the Bishops Art District has more childrens clothes (girls 0-14) (boys 0-7) per square inch than can be contained. They even put racks out on the porch of this reused home. However, clothing and a few items that may belong in a diaper bag are the specialty so don't expect an array of children's items. The clothing is a wide variety and definitely tips the cuteness factor. If a baby shower is in the future, stopping here might just be what is needed.
»Emporium Pies
Emporium Pies serves up a selection of delicious gourmet pies that will surely change the way you think about this humble, classic dessert. Every pie is prepared using all natural, seasonal ingredients, creating a menu that changes with the seasons, offering new treats to discover and explore. Some popular regulars include the smooth operator with French silk chocolate and a pretzel crust, the cloud nine with caramel, butterscotch and brown sugar meringue, and the Drunken nut with bourbon pecan and shortbread crust. Sweet, scrumptious and unlike anything you have tasted before, these pies will certainly keep you coming back for more.
»Inessa Stewart's Antiques
Largest source for Continental European antiques in the USA, Inessa Stewart's Antiques boasts of a huge collection of collectibles in three showrooms in two states. The store is home to an amazing collection of antiques and art from all over the continent which are perfect for decorating and furnishing your home and office. The Inessa Stewart Collection is a brilliant assemblage of new items designed to complement the classic European look, with over 400 paintings, and hundreds of other decorative items. All items are hand-selected by Inessa and lovingly restored by their expert in-house staff. Shop from over 4,500 items on their comprehensive website which is updated daily. Check website for more details.
»Crystal Images
Choose a unique gift of personalized crystal, glass, and marble while at this store that carries a large variety of items to engrave including jade and starphire awards, coffee mugs, wine bottles, wall plaques, sports prizes, desk name plates, paperweights, and baby gifts.
»Art of Old India
Bringing to the US market rare Asian imports since 1974, Art of Old India is a renowned decorative showroom. This award-winning establishment presents valuable pieces which are highly sought after by designers, architects and builders. Find intricately carved ceiling panels, columns, arches, antique furniture, trunks, armories, rugs, velvet carpets, fine textiles, decorative doors, lightings, mirrors, and other fancy furnishings here.
»King's Cross Antiques
One of several antique dealers in the Knox-Henderson area, King's Cross offers a wide variety of English and French antiques. There are Georgian, Victorian and Edwardian pieces along with porcelains from Staffordshire and Majolica. Country French and Provencial furniture pieces complement the Flow Blue and Blue Willow pottery collections. Whether you're looking for something special to decorate your home or a unique gift, you're sure to find something here that catches your eye.
»Wild Bill's Western Store
For those who crave a true Texas experience, this specialty store is definitely a must-visit. Whether you are looking for a souvenir for your aunt, cowboy hats for your kids, a pair of cowboy boots for yourself, or even an extravagant gift for that special someone, you can find it all at Wild Bill's. The store caters to Dallas' out-of-town visitors by offering shipping worldwide.


text:
Job Openings
Contact Us
thredUP Inc.
114 Sansome St
5th Floor
San Francisco, CA 94104
(617) 575-9676
Retail Pricing Specialist - San Leandro
We are rapidly scaling up our product offerings and are seeking an individual with a passion for fashion, brands, pricing, and ecommerce to help us establish and validate our brands and categories.
What You'll Be Doing
- Identify and establish value of new brands and categories
- Monitor pricing of existing brands and update as needed to ensure prices are being set appropriately
- Identify high-end brands and products, setting merchandise value.
- Research pricing anomalies
- Provides in-depth research on brand products and pricing to determine pricing structure, standards and range
- Provides on-site expertise for clothing valuation
- Assists in determining appropriate product categories and attributes.
- Assist in ad-hoc pricing and inventory analysis, as needed
- Interacts with Customer Service, Product Marketing, Merchandising, Warehouse Operations and Development organizations to help set and resolve pricing issues.
The Ideal Candidate
- A minimum of 2+ years retail, fashion, or other team oriented production environment or equivalent.
- Strong communication skills (reading, writing, presentation, and speaking).
- Strong teamwork skills with the ability to work well with others
- Passion for brands, fashion and pricing, and E-commerce
- Attention to detail, positive attitude, punctuality and reliability
- Ability to deliver results under tight deadlines
- Comfort with Microsoft Word, Excel
- Experience/dexterity using handheld electronic devices (e.g., scanners, cameras, and smart phones), desktop computers
- Preferred degree in fashion related program or equivalent. New Grads welcome to apply.
- Ability to lift/carry up to 30 lbs, push/pull wheeled clothing racks weighing up to 150 lbs, flexibly shift between multiple workstations, and actively use a smart phone for continuous periods up to 3 hours. I.e., this role requires moderate physical effort such as the ability to stand or walk for long periods of time, bend down, and reach overhead.
Just So You Know
- This position is based at 2992 Alvarado Street, San Leandro and is subject to the local labor and wage statutes of that city.
- At this time we are considering only local candidates who are able to work without employer sponsorship.
- We are an equal opportunity employer.
To Apply
If you are interested in applying for this job, send us a brief but thoughtful cover email to email@example.com explaining why you're perfect for this job and include a link to your portfolio.


text:
The Global Intelligence Files,
files released so far...
Index pages
by Date of Document
Our Partners
Al Akhbar - Lebanon
Al Masry Al Youm - Egypt
Asia Sentinel - Hong Kong
Bivol - Bulgaria
Carta Capital - Brazil
CIPER - Chile
Dawn Media - Pakistan
L'Espresso - Italy
La Repubblica - Italy
La Jornada - Mexico
La Nacion - Costa Rica
Malaysia Today - Malaysia
McClatchy - United States
Nawaat - Tunisia
NDR/ARD - Germany
Owni - France
Pagina 12 - Argentina
Philip Dorling - Fairfax media contributor - Australia
Plaza Publica - Guatemala
Publica - Brazil
Publico.es - Spain
Rolling Stone - United States
Russian Reporter - Russia
Ta Nea - Greece
Taraf - Turkey
The Hindu - India
The Yes Men - Bhopal Activists
Sunday Star-Times - New Zealand
Community resources
courage is contagious
The Global Intelligence Files
On Monday February 27th, 2012, WikiLeaks began publishing The Global Intelligence Files, over five million e-mails from the Texas headquartered "global intelligence" company Stratfor. The e-mails date between July 2004 and late December 2011. They reveal the inner workings of a company that fronts as an intelligence publisher, but provides confidential intelligence services to large corporations, such as Bhopal's Dow Chemical Co., Lockheed Martin, Northrop Grumman, Raytheon and government agencies, including the US Department of Homeland Security, the US Marines and the US Defence Intelligence Agency. The emails show Stratfor's web of informers, pay-off structure, payment laundering techniques and psychological methods.
B2* -- HUNGARY -- Hungary stocks, currency plunge on fears may be next Iceland
Released on 2013-02-13 00:00 GMT
Email-ID | 5087837 |
Date | unspecified |
From | email@example.com |
To | firstname.lastname@example.com |
By Zoltan Simon
Oct. 15 (Bloomberg) -- Hungary's key stock index and currency plunged on
investor fears that the country may the next to be engulfed by the
financial crisis that caused the meltdown of the Icelandic economy.
The benchmark BUX index plummeted as much as 7.7 percent and the forint
slumped 5.4 percent against the euro today. The stock market is the
world's worst performer in euro terms today, while the currency fell more
than any other, except the Paraguay guarani.
The global financial crisis is hitting more vulnerable emerging markets as
investors withdraw from riskier assets in a flight to safety. Hungary
lined up potential funding from the International Monetary Fund this week
as a ``last line of defense'' after what Prime Minister Ferenc Gyurcsany
called a ``significant and strong attack'' against local markets.
``There are market rumors, linked to the IMF agreement, that Hungary may
be next after Iceland,'' said Daniel Bebesy, an economist at Budapest
Investment Management. ``There isn't much basis for this but when there is
panic, a rumor is enough to cause a lot of damage.''
The forint traded at 263.75 per euro at 12:25 p.m., compared with 253.75
late yesterday. The BUX was down 7.6 percent at 15,184.62. OTP Bank Nyrt.,
the nation's largest lender, fell as much as 13.1 percent to 3,866 forint
and traded at 3,910 forint.
Hungarian assets are being sold off even after government officials and
analysts said that the banking system is stable and the country reduced
its external vulnerabilities. The government has cut the budget deficit
from a record 9.2 percent of GDP in 2006 to a planned 3.4 percent this
year and pledged to meet all euro-adoption terms next year.
Icelandic Implosion
Iceland's financial system imploded, precipitating the collapse of the
currency after the country's three largest banks amassed $61 billion of
debt. Iceland's Prime Minister, Geir Haarde, said yesterday the country
won't default on its state debt. Stocks fell 77 percent yesterday.
The Hungarian central bank has been organizing daily currency swap tenders
since Oct. 13 to boost liquidity, while the government has guaranteed all
bank deposits and said it will cut net bond sales this year and only issue
notes to replace expiring debt.
Suspended Loans
Oesterreichische Volksbanken AG's Hungarian unit has suspended Swiss Franc
and U.S. dollar loans, Nepszabadsag reported today, citing Erik Gobl, an
official at the local unit's marketing department. It will continue to
lend euros it has in reserves.
Bayerische Landesbank was the first bank in Hungary this week to announce
the suspension of new foreign-currency personal loans, saying the
volatility of the forint made them too risky for clients.
``There is concern about the banking system and over how much people have
borrowed in euros and Swiss francs to finance mortgages and personal
consumption,'' London-based RBC Capital Markets economist Nigel Rendell
Rendell said the forint, the world's second-best performing currency in
the second quarter, was overvalued given the size of the country's
current-account deficit. Still, the current slide in Hungarian assets was
``exaggerated'' because of the panic that reins over world markets, he
``We're not really living in a rational market,'' Rendell said. ``It was
driven by greed for years and now it's driven by fear.''


text:
Narrow your search
Whether you want a high-quality printer, an all-in-one workhorse, a compact photo printer, or a simp
The HL-2360DW is a strong choice if you're shopping for a text-only printer that can print from the cloud and won't empty your wallet on toner refills.
Pricing not available
The tech industry easily convinced the public to accept a myriad of free services for the price of some loss of privacy. But getting them to embrace the smart home is going to be a far harder sell.
The reborn Ford GT is the hottest car of the 2015 NAIAS in Detroit. We spoke with its designer, Moray Callum, to learn about how it went from sketch to concept car in just 14 months.
In a fascinating survey, IT managers reveal some of the dubious activities they view being perpetrated by employees on work computers. These cause the IT managers extra stress and work (as well as, no doubt, the occasional fascination).
Good news! Reverse password lookups are totally possible.
We sat down with the Briggs brothers at BAC to hear the story behind the Mono.
"Oh man! Destruction Derby!" Seniors have fun stealing and wrecking cars, shooting random people and running from the police as they play Grand Theft Auto V in this Fine Brothers video.
The contents of the bowels of an Italian medieval warlord have revealed his nefarious cause of death nearly 700 years later.
The UE Megaboom Bluetooth speaker one-ups its little brother with a range of improvements, including a larger size, bigger sound (particularly on bass), better waterproofing and extended battery life.
Pricing not available
LG Display expects to move 600,000 OLED panels in 2015 and 1.5 million in 2016, the company CEO said, with the promise to be leaders in OLED screen technology.


text:
- Added: 21 May, 2013
- Idol: Yuria Ayane
- Duration: 112 minutes 30 sec ( 4 scenes )
- 0%
- Add to Favorites
This DVD Movies
Featured model : Yuria Ayane
Inviting the new girl in the office out to get to know each other better means something way different between Yuria Ayane and her boss, as she quickly gets acquainted with his large cock before he´s ripping her pantyhose open and massaging her big tits. She shows initiative when she´s spreading open for him, and getting cum on her pretty face!
Office yeen Yuria Ayane fucked by her boss in ripped pantyhose
- 75%
- Movie size : 1 Gb
- Movie length : 33:45
Featured model : Yuria Ayane
Yuria Ayane nice Asian teen is in the office. She is in the break room and getting it on with a horny co worker! She gets her pussy licked through ripped pantyhose, and she is fingered before swallowing cock in a hot blowjob. She gets her big tits fucked in hardcore action and ends their group with cum on her pretty face!
- 100%
- Movie size : 773 Mb
- Movie length : 27:51
Featured model : Yuria Ayane
Her bosses are ready to test the new office girl out, and Yuria Ayane is up to the task in this threesome! She gets stripped to her thigh high stockings in their office, as they make good use of her holes. Her pussy feels the rub of a vibrator first, and then takes on their dicks one by one, as they shoot their loads in her mouth and on her face!
Asian teen Yuria Ayane fucked by two bosses with dicks and toys
- 80%
- Movie size : 958 Mb
- Movie length : 39:57
Featured model : Yuria Ayane
In the middle of her shift, Yuria Ayane gets naughty at work by dropping down on this guy and pulling his cock out from his zipper to suck him off. She swallows his whole cock, especially when he grabbed her head and throat fucked her. That´s how you know she wanted to do anything she could to make him shoot her for a cum facial!
- 0%
- Movie size : 301 Mb
- Movie length : 10:57
Our DVD's Archive
- IN Nampa Limited C..
- % min. sec.
- Fluid Exchange, In..
- % min. sec.
- New Comer - Exclus..
- % min. sec.
- Online Thick Syrup..
- % min. sec.
- New Amateur Sexymi..
- % min. sec.
- Ryohana Asakura - ..
- % min. sec.
- Supernova Ayaka Fu..
- % min. sec.
- I Love My Dildo Vo..
- % min. sec.
- A Woman´s Bo..
- % min. sec.
- this woman,. super..
- % min. sec.
- Premium Stylish So..
- % min. sec.
- Mikuri Kawai - Cut..
- % min. sec.


text:
On June 6, the U.S. Court of Appeals for the District of Columbia Circuit handed down a ruling that will serve as important precedent for the ongoing federal legal battles over the Keystone XL and Flanagan South tar sands pipelines.
In the Delaware Riverkeeper v. Federal Energy Regulatory Commission (FERC) case, judges ruled that a continuous pipeline project cannot be segmented into multiple parts to avoid a comprehensive National Environmental Policy Act (NEPA) review. This is what Kinder Morgan proposed and did for its Northeast Upgrade Project.


text:
"A great loop on the mountainside of the Kingdom Trails with fantastic downhills and big climbing."
15.525.0 milesKilometers | 2,126'648 m Ascent | 2,053'626 m High | 5.2% Avg Grade |
90% Singletrack | -2,141'-653 m Descent | 824'251 m Low | 16.1% Max Grade |
2:15 average ride time for 17.0 miles. DetailsHighlighting J-Bar and Moose Alley, this loop is a fine introduction to this side of the trails. Need To Know
A day pass to the private trails costs $15/per person. There are shuttles to various locations on the weekends.
This loop starts and ends at the Burke Mountain Campground. However, it could be started at Middle Burke parking area as well.
Pedal up the switchbacks and wooded climb of Camp-town and take a right on the doubletrack traverse of CCC Road where you'll cross some of the Burke slopes. Take a right on J-bar where you'll enjoy an awesome and flowing downhill all the way down to Burke Lodge. The downhill is full of roots, jumps, bumps and a bridge or two. From the lodge, head back out to the road and take a right. From there hang a left on Dashney Road where you'll follow the gravel to Trillium. Here it gets slightly confusing as the Nordic trails are also on this section but not marked on the trail map. You'll follow Trillium to Magill Fields and cross the road. Then get on Moose Alley. Moose Alley is a long and super-fun downhill that goes through beautiful and serene forest with a nice flow. Once you spill out onto Smith Hill Road, you'll follow that across the main road where you'll cross a bridge, then take a left on White School. This trail will climb up to the top of Sky Dive which is another great signature downhill. Sky Dive will take you back to White School where you'll take a quick right, then left on Nose DIve. Then right on White School to follow the river back to East Darling Hill Road. A quick right up to Sugarhouse Run on the left where you'll take a left on Kitchel and enjoy the machined berms as you flow back to town. Then, last but not least, a rough road climb back up to the campground. COMMENTS OTHER RIDES NEAR HERE
Your To-Do List: Not on it Add it! | Your Full List »
Your Check-Ins:
Your Opinion:
Share This Page
Improve This Page


text:
Horsemeat scandal
Europe's mushrooming horsemeat scandal saw its first arrests Thursday _ and saw French authorities name a French wholesaler as the main culprit in disguising cheap horsemeat as ground beef for frozen foods sold around the continent. AP video. (Feb. 14)
advertisement | advertise on newsday
Forensics, bridges and eggs at Science Olympiad
Girl Scouts attempt to break Guinness record
Give me an U-N-D-E-F-E-A-T-E-D
Child calls 911, man rescued from fire
Opponents of casino file lawsuit
MTA urged to screen LIRR engineers for sleep disorders
Westbury casino plan faces towns' lawsuit
Woman struck by pickup truck in Copiague
Angie Carpenter named Islip Town supervisor
NICE to increase MetroCard bus fares by 25 cents
The North Fork digs out
Raw video: Blaze guts Uniondale home


text:
Ms. Jennifer B. Potter
Hematology/Oncology, Texas Oncology Medical City
- 7777 Forest Ln Ste D400
Dallas, TX 75230 - 1 Office Location
- (972) 566-7790
Ms. Potter works in Dallas, TX and specializes in Hematology/Oncology. Ms. Potter is affiliated with Baylor Medical Center and Medical City Dallas Hospital. Ms. Potter speaks English, Spanish, Tagalog and Vietnamese.
Gender: Not Available
Years in Practice: Not Available
Languages Spoken: English, Spanish, Tagalog, Vietnamese
Medical School: Not Available
Graduation Date: Not Available
Hospital Affiliations: Baylor Medical Center, Medical City Dallas Hospital
Specialties: Hematology/Oncology


text:
Your cart is empty!
Calms the skin and soothes irritation caused by the sun. Cooling and moisturizing herbal extracts give the skin a wonderful freshness. Provitamin B5, aloe vera, and allantoin protect the skin from dryness and support the recovery process.
Aqua (water), alcohol, glycerin sodium lactate, chondrus crispus (carrageenan), viola tricolor extract, xanthan gum, panthenol, scrose cocoate, hamamelis virginiana (witch hazel) extract, allantoin, phernethyl alcohol, achillea millefolium extract, aloe barbadensis leaf juice, chamomilla recutita (matricaria) flower extract, camphor, menthol, lactic acid and rosmarinus officinalis (rosemary) leaf extract.
Apply to skin after exposure to sun.
Solarcaine burn relief aloe extra gel - 8 oz
Our Price:$5.69
Fruit Of the Earth Aloe Vera Cool Blue Gel Bottle - 20 OZ
Our Price:$5.10
Neutrogena Ultra Sheer Dry-Touch Sunblock, SPF 55 - 3 OZ
Our Price:$8.71
Cover Girl Outlast All Day Lipcolor, Toasted almond #628, 2 ea
Our Price:$16.67
Product descriptions and images presented on the site are for representational use only and do not constitute or substitute for medical information from your health care or medical professional. Information on this site is provided for informational purposes only. You should read carefully all on correct product packaging and follow the instructions. If you have or suspect that you have a medical problem, promptly contact your health care provider. Information and statements regarding dietary supplements on this site have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease and may be for commercial. Image shown for reference only. Actual item you recieve may differ from shown.


text:
Batkid's IRL exploits tugged on our heart strings. Now Julia Roberts is making them into a movie.
Organize your Netflix queues accordingly.
Because he's the toddler Gotham deserves, but not the one it needs right now.
The latest Age of Ultron trailer is, like, really good.
Can Batman ever be happy? We'll have to wait til 2017 to find out.
A professional psychologist takes a deeper look at 'Batman: The Animated Series.'


text:
Now Playing
Connect with Us
Podcasts & RSS Feeds
All Content |
View all podcasts & RSS feeds |
Most Active Stories
Arts & Life
5:55 am
Thu December 27, 2012
Volunteers, Relief Groups Help Ala Storm Victims
Relief agencies and volunteers are helping out victims of the tornadoes that hit Alabama on Christmas Day.
The American Red Cross says volunteers have distributed bottled water, shovels, rakes and clean-up kits to people in Mobile and Prichard, where dozens of homes were damaged. They've also provided tarps to people whose roofs were damaged.
The Salvation Army says it has fed more than 1,000 people in Mobile, and it's also providing food in Troy. A tornado caused widespread damage in the southeast Alabama county.
The Alabama Emergency Management Agency says Mobile, Pike and Marengo counties were hardest hit by severe storms that pummeled Alabama on Tuesday.
No serious injuries were reported. State emergency management director Art Faulkner says people are taking weather warnings seriously since the April 2011 tornadoes.
Copyright 2012 The Associated Press.
Arts & Life
Arts & Life
Emergency Preparedness


text:
On Tour in T.O.
How to make the most of your Grey Cup visit to Toronto Add to ...
TORONTO — The Globe and Mail
Last updated
Tour Guide: Some pointers to football fans visiting Ontario's capital city for this year's CFL Championship game
Watch More Video:
Patriots or Seahawks? Animals predict Super Bowl winners
Justin Bieber posts video apologizing for recent behaviour
Fans gear up for Super Bowl of snacks
Seahawks fans hoist 12th-man flag in Victoria
Katy Perry drops hints about Super Bowl halftime Show
New legal woes for Lohan
Super Bowl host city reeling over sports deals
New Movies: Jessica Chastain and Oscar Isaac in 'A Most Violent Year'
Here's how room to breathe helped a Fashion District condo sell fast
All-female Ghostbusters cast announced via twitter
Canadians support troops firing on Islamic State militants, Harper says
Just how does that yellow first down line work?
Brad Pitt puts on his producer hat for Sundance
Start prepping now for your Super Bowl BBQ bash
Lotus releases pictures of 2015 Formula One car
Eddie Redmayne and Julianne Moore look forward to Oscars
Miss Colombia wins Miss Universe title
James Franco on why he didn't meet murderer
Axe-carrying suspect caught on security video in southern Ontario
Molly the 1,200lbs cow rescued from mineshaft in California


text:
Long delays. Hunger. Thirst. Cramped seats. Sick passengers. Paramedics called in. Information from the crew that turned out to be untrue.
The Supreme Court of Canada has rejected a claim for financial compensation by an Ottawa couple who sought damages from Air Canada when, among other things, they couldn't order a 7Up in French. In a 5-2 decision, the top court ruled Tuesday there was no dispute that the airline violated Michel and Lynda Thibodeau's French-language rights during three international flights in […]
Who knows how some rumours get started, but the story that Ottawa's international airport didn't really want a rail connection because it would cut into its parking revenue has been a persistent one. One thing is clear though: that theory didn't come from Mark Laroche.
The reality TV series Ice Pilots NWT provides a recap of NHL players' charity tour of the region in November 2012.
Snow removal crews worked through the night to clear the roads after Eastern Ontario was hammered by a storm, prompting Ottawa police Chief Charles Bordeleau, city staff and councillors to thank them on Twitter Saturday morning.
After dozens of cancellations over two days because of hurricane Sandy, air travel from Ottawa to the eastern United States is slowly returning to normal.
Superstorm Sandy grounded more than 15,000 flights across the Northeast and the globe, and it could be days before some passengers can get where they're going.
Airlines can be sticky about these instruments, no matter how rare and valuable.
WestJet Airlines Ltd. will be hiking its quarterly dividend to shareholders by 33 per cent and offering passengers more legroom for a new class of premium seating.


text:
Five long months at 3 lbs per month. Ten to go. Nice to see my feet again. Nice to actually fit in size 36 pants.
This is a discussion on 15 down, 10 to go. within the Off Topic & Humor Discussion forums, part of the The Back Porch category; Five long months at 3 lbs per month. Ten to go. Nice to see my feet again. Nice to actually fit in size 36 pants....
Five long months at 3 lbs per month. Ten to go. Nice to see my feet again. Nice to actually fit in size 36 pants.
"The heart of the wise inclines to the right, but the heart of the fool to the left." Eccl. 10:2
Great job! Keep it up.
I have been on my own personal fitness crusade as well. Its been tough lately as I havent been working (on leave). It will be nice to head back to work, although I wont be with my wife for a couple months, I will get my diet back in check. She cooks too good!
Please take my posts with a grain of salt. I am frequently sleep deprived and always just on this side of "Krazy".
When bad men combine, the good must associate; else they will fall one by one, an unpitied sacrifice in a contemptible struggle. Edmund Burke
Congrats! However, I wish that you guys would stop losing all of this weight! Being the great detective that I am, I keep finding it!
You can educate ignorance, you can't fix stupid
Retired DE Trooper, SA XD40 SC, S&W 2" Airweight
dukalmighty & Pure Kustom Black Ops Pro "Trooper" Holsters, DE CCDW and LEOSA Permits, Vietnam Vet 68-69 Pleiku
Congrats! I've been trying to lose some also, down about 30 pounds in a year, still want to lose 5 more but for some reason the last 5 is impossible for me .
Keep it up.
Congrats, my other half is also trying to lose weight...and give it to me. She's trying to lose 30 before our wedding...in sept. So we joined a gym, and got a trainer.
I know not what this "overkill" means.
Honing the knives, Cleaning the longguns, Stocking up ammo.
Last year I went from 205 to 182, or so over the course of several months for NO APPARENT REASON.
Went to the docs, ran a boatload of tests, as I was begining to sweat it a mite, as I wasn't TRYING to lose the weight.
Doc said good for me, as it was nothing serious.
Long story short, it was probably due to stressing,
Wish I could have bottled whatever it was that happened to me, and sell it, I'd be filthy rich by now.
Still weigh around 188.
Who could figure?????????
I would rather die with good men than hide with cowards
If you want to make God laugh, tell him your plans.
Politics is the art of looking for trouble, finding it whether it exists or not, diagnosing it incorrectly, and applying the wrong remedy."
M&Pc .357sig, 2340Sigpro .357sig
Congrats, and keep it up! Lower weight and lower BMI generally a longer better life!
The tyrant dies and his rule is over, the martyr dies and his rule begins. ― The Journals of Kierkegaard
Been at it sice the first of the year, diet and going to the gym.Down two pants sizes, about 20. The last 15 are going to be tought, seem to have leveled off.
I'd rather be lucky than good any day
There's nothing that will change someone's moral outlook quicker than cash in large sums.
Majority rule only works if you're also considering individual rights. Because you can't have five wolves and one sheep voting on what to have for supper.
Thanks, guys, and kudos to y'all as well. It seems that the last five or ten are the most stubborn. "The stress diet". Works every time. When I was dating my wife her roommate had broken up with a guy. Dropped three dress sizes. She should break up more often. LOL!
Hiram - that was a gooder.
"The heart of the wise inclines to the right, but the heart of the fool to the left." Eccl. 10:2
Seems like many of us have been trying to loose weight. I have lost about 8 lbs in the last three weeks... i went from vegging out on couch to using my exercise bike 30 minutes a day, and hitting my Smith machine that has been collecting dust for years. It is good to be working in the proper direction, and have about 18 pounds more to go... 40 more if i listen to my doctor. I think a few extra pounds is actually a good thing.. helps you in the lean times. Congrats on your weight loss... are you afraid you will slowly gain them back over time? thats what i am worried about. Bunker
"6 P's of self defense "
Prior Planning Prevents Piss Poor Performance
My wife has tried just about every diet, and is currently on the same one Rush Limbaugh lost all that weight on - she's lost 30 lbs so far. I asked her which one would be the best for me and she told me the Weight Watchers Points. So I started it and I've lost 14 lbs in 9 weeks. Figure I've got about another 14 lbs to go, but so far so good.
If you have a smartphone (iPhone, Android, Blackberry), and you're wanting to lose some pounds, try the "Myfitnesspal" app. It's very cool - you input your current parameters and target weight, and then use the app to record your eating and exercise activities.
It gives you a daily calorie target and as you input your meals and snacks, it counts down. Stay within your daily allowance, you'll lose a pound a week. Go for a jog or something, you can add to your allowance and earn calories.
What we know about weight loss is that exercise is good for you, but it isn't all that great for losing weight. It's really about eating.
"It may seem difficult at first, but everything is difficult at first."


text:
People News
Ratings News
Scheduling News
Application News
Spoiler News
Show Updates
Features & Interviews
Image Gallery
Message Boards
Shows Listing
19 Kids & Counting
The Amazing Race
American Idol
America's Got Talent
America's Next Top Model
The Apprentice
Bachelor in Paradise
The Bachelor
The Bachelorette
Big Brother
The Biggest Loser
Dance Moms
Dancing with the Stars
Duck Dynasty
Hell's Kitchen
Here Comes Honey Boo Boo
Keeping Up with the Kardashians
Kendra On Top
Last Comic Standing
MasterChef Junior
Pawn Stars
Project Runway
The Real Housewives
Shark Tank
So You Think You Can Dance
Swamp People
Teen Mom
Top Chef
True Tori
The Voice
More Shows
American Idol
American Idol 2
'American Idol' Gay Idol Journal - "The Neil Sedaka Hits Edition"
By Reality TV World staff, 05/06/2003
Larry Johnson, a comedy writer currently working for Disney TV, has posted the latest installment of his weekly '
American Idol
' Gay Idol Journal diva rant, an exclusive to the RealityTVWorld
American Idol
message boards.
Check it out by clicking
American Idol Message Boards
RealityTVWorld: American Idol
RealityTVWorld: American Idol 1
RealityTVWorld: American Idol 2
RealityTVWorld: American Idol 3
RealityTVWorld: American Idol 4
RealityTVWorld: American Idol 5
RealityTVWorld: Clay Aiken
RealityTVWorld: Ruben Studdard
RealityTVWorld: World Idol
SirLinksALot: American Idol
More American Idol 2 News
Former 'American Idol' finalist Kimberly Caldwell gets married!
Clay Aiken loses Congressional bid in North Carolina but gains his own reality special on Esquire Network
Josh Gracin apologizes for suicide scare, says he's getting help
Former 'American Idol' finalist Josh Gracin reportedly on psychiatric hold after posting public suicide note
Clay Aiken: My political career is more difficult than 'American Idol'
'The Biggest Loser' crowns Toma Dobrosavljevic Season 16 champion, runner-up Sonya Jones loses by one pound
'The Bachelor' bachelorette Juelia Kinney: Chris Soules would be lucky to have Britt Nilsson
Bruce Jenner reportedly filming his own E! reality show documenting his "journey"
'The Bachelor' host Chris Harrison: Kelsey Poe is kind of a spoiled brat, Ashley Iaconetti is immature and obsessed with herself
Bruce Jenner steps out with fuller-looking lips
'The Bachelor' star Chris Soules: I think my Final 3 bachelorettes will surprise everyone
Farrah Abraham may still want to get her butt done despite recent botched lip injection procedure
Kim Kardashian on Kanye West relationship: It's so normal, he even makes me lunches
Ashley Hartman
Carmen Rasmusen
Charles Grigsby
Clay Aiken
Corey Clark
Josh Gracin
Julia DeMato
Kimberley Locke
Kimberly Caldwell
Paula Abdul
Randy Jackson
Rickey Smith
Ruben Studdard
Ryan Seacrest
Simon Cowell
Trenyce Cobbins
Vanessa Olivarez
Lil Wayne sues Cash Money for $51 million over breach of contract
Justin Bieber apologizes for his "arrogant" behavior
Taran Killam, Cobie Smulders welcome second child
Taylor Swift "died" after learning Madonna likes her music
Katie Cassidy "thrilled" to portray Black Canary on 'Arrow'
Kate Hudson stuns in cutout dress at Versace show
Zachary Quinto won't appear on 'Heroes Reborn'
Taylor Swift shares bikini photos of Hawaii vacation with Haim
Take Our User Survey
Page generated in 0.83368587493896 seconds
About Reality TV World
Advertise on Reality TV World
Contact Reality TV World
Privacy Policy
RSS Feed


text:
Series: Springer Optimization and Its Applications, Vol. 28
Pronzato, Luc, Zhigljavsky, Anatoly (Eds.)
Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.
You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.
After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.
price for USA
digitally watermarked, no DRM
Included Format: PDF
download immediately after purchase
Hardcover version
You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.
Standard shipping is free of charge for individual customers.
price for USA
free shipping for individuals worldwide
usually dispatched within 3 to 5 business days
Softcover (also known as softback) version.
You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.
Standard shipping is free of charge for individual customers.
price for USA
free shipping for individuals worldwide
usually dispatched within 3 to 5 business days
This edited volume, dedicated to Henry P. Wynn, reflects his broad range of research interests, focusing in particular on the applications of optimal design theory in optimization and statistics. It covers algorithms for constructing optimal experimental designs, general gradient-type algorithms for convex optimization, majorization and stochastic ordering, algebraic statistics, Bayesian networks and nonlinear regression. Written by leading specialists in the field, each chapter contains a survey of the existing literature along with substantial new material.
This work will appeal to both the specialist and the non-expert in the areas covered. By attracting the attention of experts in optimization to important interconnected areas, it should help stimulate further research with a potential impact on applications.
Content Level » Research
Keywords » Bayesian networks - SOIA - algebraic statistics - algorithms - gradient-type algorithms - linear optimization - optimal design theory - optimization
Related subjects » Applications - Computational Science & Engineering - Mathematics - Probability Theory and Stochastic Processes - Statistics - Theoretical Computer Science
Get alerted on new Springer publications in the subject area of Optimization.


text:
Canadian food safety officials have outpaced their U.S. counterparts in requiring meat companies to label meat that is potentially hazardous to consumers. It's called mechanically tenderized beef, and it has caused illnesses in the U.S., Canada and elsewhere. And in most cases, consumers, restaurants and grocery stores had no idea they were buying it, because ...Continue Reading
Bread! KC is a series of micro-financing events that raises project funding for artists. Ashley Holcroft, a producer from KCPT's "Arts Upload," recently visited one of the group's events. Here's how it works: people purchase tickets which entitle them to a dinner and a vote. They hear three short presentations and then vote on which ...Continue Reading
Who in the news do you think deserves a pat on the back or kick in the pants? The Roasts and Toasts segment on the program is designed to be audience-generated. We know you have opinions… so, add your voice to the weekly food for thought fight on the news of the day and trends ...Continue Reading
Share your insights and experiences with KCPT.
Why We Love the Game VIDEO
There is no sport like baseball.
Joan Rivers was unapologetic in her comedy, often using her wit and wisdom to highlight injustices in society. Track the rise of women in the world of comedy, from the "dangerous" comedy of 70s sitcoms like "Maude" to the groundbreaking women of the 1980s American comedy club boom to today's multifaceted landscape: MAKERS: Women in ...Continue Reading


text:
15 unique illnesses you can only come down with in German
American Christianity is losing its grip on political power
Mitt vs. Mitt the movie
Gay funerals: What would Jesus do?
The latest Tweets on 'WikiLeaks'
An American Charlie Hebdo?
Thanks a lot, austerity! We could have had 2014's economic recovery in 2011.
American Christianity is losing its grip on political power — and that's good news for Christians
Rand Paul to drone fliers: 'Beware, because I've got a shotgun'
E-cigarettes labeled a 'health threat' in California report
Supreme Court orders Oklahoma to halt executions over lethal injection drug
Gossip: Erin Andrews


text:
Well I am 41. Not that young any more. But we have a whole pot of Pypers here in Northern Illinios. We have always been told of our heritage from Scotland but I have never traced it back. Love to hear from you. Cindi
Home | Help | About Us | Site Index | Jobs | PRIVACY | Affiliate |
© 2007 The Generations Network |


text:
Homewood Suites by Hilton Madison West
The Homewood Suites by Hilton Madison West Wisconsin hotel has 122 spacious studio suites, one-bedroom suites and two-bedroom suites that will make guests feel right at home. Each suite has a fully-equipped kitchen with full-size refrigerator, range top, microwave, dishwasher and sofa-bed in the living area as well as a large, flat panel TV with premium channels, including HBO, wireless and wired high-speed internet access, DVD player, iron and ironing board, hair dryer and coffee maker to name just a few of the hotel amenities.
Take US-12 W to Mineral Point Rd. Exit (#254). Turn left on Mineral Point Rd. Turn left on Commerce Dr.
- Pets Welcome/Inquire
On-site Hotel/Motel Amenities
- Fitness Center
- Internet
- Pool/Waterpark
Events: Near Homewood Suites by Hilton Madison West
Bolz Conservatory Exhibit: Innovations Inspired by Rainforests
11/1/2014-3/1/2015 - Madison - 9.73 miles away
UW Men's Hockey vs. Minnesota
1/30/2015-1/31/2015 - Madison - 6.4 miles away
Olbrich Gardens: Cocktails in the Conservatory
1/30/2015 - Madison - 9.73 miles away
Scandihoovian Winter Festival
1/30/2015-2/1/2015 - Mount Horeb - 11.2 miles away
Michael Feldman's Whad 'Ya Know?
1/31/2015 - Madison - 7.54 miles away
Orchid Quest
1/31/2015-2/1/2015 - Middleton - 2.23 miles away
2015 Frostiball
1/31/2015 - Madison - 6.92 miles away
Music Crawl
1/31/2015 - Belleville - 12.63 miles away
1/31/2015 - Madison - 6.41 miles away


text:
Most read:
- Oracle is quietly becoming a cloud giant
- Scared of 802.11AC Wave 2 Wi-Fi? Here comes Cisco Multigigabit to the rescue
- 8 Wi-Fi mistakes to avoid
- Microsoft finally does the right thing, makes Windows 10 a free upgrade
- Conference calls a waste of time? In 1915, this one made history
- Windows 10 to be free upgrade for many during its first year


text:
Home |
Very Fine Japanese Kutani Haisen, Compote browse these categories for related items... Directory: Antiques: Regional Art: Asian: Japanese: Porcelain: Pre 1910: item # 1024866 Please refer to our stock # 021158 when inquiring.
SANAI FINE ART & ANTIQUES P. O. Box 495633 Garland, Texas 75049-5633 Phone: 972-270-3960 Guest Book Sold |
The size of Compote: 5 7/8" Dia x 4 5/8" High. Japanese Porcelain Kutani compote. This is beautiful and exquisite works of painting done over the porcelain. The shape of compote is fine one. The top rim has waving work so evenly done. The workmenship is best one I have seen in Kutani piece. Some scholar also called Kutani Satsuma. Outside top area with four different window works. Each window has different subject, one with Peacock, next one with collectors or artist showing their works of paintings, third one with landscape. last one showing with writing scroll. Each of paintings are highlighted with fine gold lines. Between the windows, there are fine decoration of white chrysanthemum as well as Karakusa design. The gold works as well as the bottom of bowl has fine geometric designs. Inside bowl has the design of Daikoku(one of seven lucky God) with two boys playing with mouse by Uchideno-Kozuchi. The face expression are also wonderful. The photo could not caputured the fine detail workmenship of gold works. Around Daikoku, there are also the detail decoration of Kiku(chrysanthemum) flowers. Inside rim as well as just below, there are four square box(cut corner) design with another fine detail designs are painted precisely. It just keep your eyes going around the compote. The condition of Compote is Excellent, no chip, no crack and no hairline. There is little bit wear at the edge of outside, but over all condition is great one. It is marked, "Dai Nippon Kutani Sei(made)". It came with wooden box. The hole on the bottom is air escape hole when was in kiln. Dating from Meiji Period (1868-1912). |
Categories | Shops | Join | Terms | Critique | Map | Help |


text:
NEW Oxford United chairman Darryl Eales has a simple solution for any supporters sceptical of his intentions – just ask him.
The prospect of a private equity expert from Birmingham suddenly becoming interested in the club raised suspicion in some quarters.
But after acquiring a significant stake in the club, described as between 30 and 50 per cent, he was keen to make assurances and spoke frankly about what motivated the move.
Eales said he wants to be part of United's long-term plan, which means putting money in, rather than taking it out.
"You read some blogs talking about 'is he going to take money out of the club?'," he said.
"I'm thinking 'if I wanted to make sensible investments you wouldn't choose football'.
"I would say to supporters, 'come and speak to me'.
"If you want to know my views on something, come and ask me because I'm new to all this, but I think people who have worked for me will say what you see is what you get.
"I don't have agendas, politics I really dislike and I'm completely open."
He added: "I don't regard football as a business, but it's got to make sense economically.
"I'm not looking to make money out of this, but I'm not looking to lose money either.
"If we started earning a profit as a business – and clearly it's loss-making at the moment – I'm very happy for 100 per cent of that to be reinvested in the club.
"You can be the judge of this, but I don't think I've got a big ego, so I'm not doing this for a big ego trip.
"I'm doing this to test myself in a different arena – in the sport I love."
Top of the 53-year-old's 'to do' list is make funds available to help Michael Appleton, who has replaced Gary Waddock as head coach, strengthen the squad.
Discussions have already taken place with incoming chief executive Mark Ashton, but it will not be a spending spree.
He said: "I've said to Mark, within sensible bounds, tell me what you need from a playing perspective and I'll flex it.
"That's not millions – I might say 'you've got an extra £250,000 to spend'."
Patient progress is the aim of the game for the new chairman, who briefly considered getting involved with Birmingham City 18 months ago before deciding against investing in the club he supports.
Eales is confident United have what it takes to move up the football pyramid, but stopped short of setting a deadline.
He said: "Realistically, to me this should be a sustainable Championship club.
"That's what we've talked about, but what I think is foolhardy is to say we're going to do that within three or five years.
"That's just your inspiration, and all our efforts will be on trying to achieve that."
- Related stories
- It's all change at Oxford United as Eales, Ashton and Appleton come in and Waddock is sacked
- Disappointed rivals now backing United for the future
- Chief exec Ashton's priority is improving United's squad
Lenagan says the chairman role was tough but rewarding
Latest United news:
Oxford Utd 2 (Hylton 18, Roberts 90+2), Exeter City 2 (Davies 37, Nicholls 87)
5:01pm Saturday 24th January 2015
JAMES Roberts struck a stoppage-time equaliser as Oxford United stopped the rot with a draw at home to Exeter City.
Oxford United sign full back Joe Skarz
2:50pm Saturday 24th January 2015
OXFORD United have made their first addition of the January transfer window by signing Joe Skarz.
Johnny Mullins backing Oxford United's quality
9:00am Saturday 24th January 2015
Johnny Mullins says Oxford United's squad have the quality to get themselves out of trouble even without help from new signings.
Plea for noisy salute today to Oxford United fan Keith Pasfield
8:00am Saturday 24th January 2015
THE KASSAM Stadium will echo to a minute's applause this afternoon to mark the death of a lifelong U's fan.
Patrick Hoban in line for Oxford United start as Will Hoskins sits out training
2:00pm Friday 23rd January 2015
PATRICK Hoban is in the frame for his first Oxford United start tomorrow after Will Hoskins suffered a mild reaction to playing last weekend.
Time's ticking, but lack of new faces not down to Oxford United's position says Mark Ashton
9:30am Friday 23rd January 2015
Oxford United's failure to secure a signing during the January transfer window has nothing to do with their position in the table, according to chief executive Mark Ashton.
Oxford United boss guarding against becoming distracted by transfer window
9:10am Friday 23rd January 2015
THE search to strengthen the playing squad may have dominated the agenda at Oxford United this week, but Michael Appleton says he has had to be careful to avoid it becoming a distraction.
Sam Long reflects on bittersweet first Oxford United goal
9:00am Friday 23rd January 2015
IF Sam Long wasn't aware of how quickly fortunes can change in football before last weekend, he certainly does now.


text:
24/7 Customer Support
Chat with a Pro
In Stock — Ships Wednesday Guaranteed
1 Question & Answer
Genuine Whirlpool part. Whirlpool brands include Whirlpool, Maytag, KitchenAid, Jenn-Air, Amana, Magic Chef, Admiral, Norge, Roper, and others. See all items in Dishwasher Basket, Silverware Basket. Whirlpool also makes various appliance models for Sears / Kenmore.
Check your model number or use our Cross Reference Tool to determine if this part will work with your appliance.
Where can I find my model number?
Repair Video
More Product Images
Part Number 8562090 (AP3886364) replaces 1180267, 8539158, 9744545, AH1156222, EA1156222, PS1156222.
Step by step instructions on how to replace a Baskt-Ware #8562090 for Dishwasher made by Kenmore. Note: This video is intended to give you the general idea of the part replacement procedure. Your appliance may differ depending on the manufacturer and model.
Did you find this video helpful?
Kathy J. for Model Number Not Sure
Answer Kathy, I am showing 8268832 is replaced by 8562088 which measures approx. 5 1/2" H x 3 1/2" D x 5" W. 9744545 is replaced by 8562090 which measures approx. 5 5/8 L"W x 5" W x 3"D. Hope this helps you. Thanks!
Was this helpful?


text:
Chargers bring in Pro Bowl CB Flowers
San Diego, CA (SportsNetwork.com) - Cornerback Brandon Flowers, cut loose by Kansas City almost two weeks ago, has found a home with an AFC West rival.
No terms of the deal were disclosed by the Chargers, but the Union-Tribune reported it is a one-year contract.
Flowers posted 68 tackles, one sack and one interception over 13 games for the Chiefs in 2013, his sixth with the franchise. That effort resulted in his first Pro Bowl selection.
That wasn't good enough to earn the trust of the club which took him with a second-round pick out of Virginia Tech in 2008. KC released him on June 13 in order to save approximately $7.5 million in cap space.
Flowers arrives in San Diego having compiled 374 tackles, 17 interceptions (three for TDs) and two sacks over 88 contests.
Join the Discussion
Miami Herald is pleased to provide this opportunity to share information, experiences and observations about what's in the news. Some of the comments may be reprinted elsewhere on the site or in the newspaper. We encourage lively, open debate on the issues of the day, and ask that you refrain from profanity, hate speech, personal comments and remarks that are off point. Thank you for taking the time to offer your thoughts.