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Community featured forum posts Ask a question to the Winsted, CT Community What's the BEST piece of wedding advice you've ever gotten/heard?(7075 views / 23 posts) Last Post by suzanH posted 4 days ago A Birthday Isn't A Birthday Without....(16245 views / 44 posts) Last Post by sonic1301890 posted 5 days ago What is the difference between an event planner and event coordinator(32712 views / 52 posts) Last Post by jodie1300242 posted December 24, 2014 The First 10 Steps for Wedding Planning(25977 views / 35 posts) Last Post by sonicsensations posted November 17, 2014 Just looking for cheap but classy not tacky wedding favours any ideas(15086 views / 46 posts) Last Post by rubyblancoutle posted November 7, 2014 start a new discussion see more posts
Top Articles featured event planning article Choosing the Right Providers for Your Wedding Posted by admin Planning your wedding can be overwhelming, but taking the time to choose the right venue, caterer, photographer, DJ, and other vendors will help create an unforgettable experience for you and your guests. Consider these tips as you begin your search and learn from the experiences of other brides. Read More
featured event planning article Party Planning 101 Posted by eventective Planning a party can be a very stressful task and many people don't know where to start. Eventective helps walk you through the process and guide your critical decisions. Read More


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What's that one measly can of soda a day -- your afternoon treat -- really going to do? Quite a bit, according to many leading health organizations.
Read Whole Story
Small changes in life can make a big difference. Meatless Monday is a step toward developing better habits. You can do it -- and you should feel better.
It's a little hard to believe, but just two years ago there was a single blogger talking about the merits of Meatless Monday.
Ultimately, this isn't about snatching your burger and throwing it in a lockbox. Nor is it about turning everyone into vegans and bark-eaters. It's about moderation, choice and starting the week off right.
Get top stories and blog posts emailed to me each day..


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I was wondering how you guys feel about the new remmington caliber the .17 Fireball.
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we'll see if it catches on, my bet is NO, the ammo wil not be cheap and so most will turn away from it, all the hype from the .17 HMRs has long gone now so only time will tell.
Since it's been around for 40 years as the .17 Mach IV, I'd say it'll last a while.
Last year I purchased a Remington 700 CDL SF Limited Ed 17 Fireball and mounted a Leupold 6-18 X scope on it . I also got five boxes of Remington 20 grain bullet ammo, darn it cost $24 per box of 20 ea. After test fireing the rifle I adjusted the trigger down to a three pound trigger pull and free floated the barrel. At 100 Yards I got 6/10 th inch five shot groups with the Rem ammo. Sofare I have shot about fifety prairie dogs at ranges between 125 and 280 yards with the factory ammo. I like the little 17 rifles and have a 17 HM2 and 17 HMR rimfire rifles and the centerfire 17 Rem rifle. I could see the pararie dogs being knock over with the scope set at 18 X and the low muzzle blast did not spook the other p dogs into their holes like when shooting them with a 22-250 Rem. My reloaded ammo using the Hornady 25 Gr HP bullet , 19.0 Gr ( MAX) of Benchmark powder, Federal 205 M primers, in Remington cases will put five bullets into .5 and .6 inch groups..MV avg is 3,880 ft/sec. When ever the snow melts I ll go out and try out the 25 Gr bullets on p dogs. I expect the 17 Fireball to make a fine 300 Yd p dog rifle where the 25 Gr bullet still has about 340 ft/lb energy. With the rifle sited in at 190 Yds the bullet is abut 7/10 th of an inch high at 100 Yds and 5.4 inches low at 300 Yds.


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Daily Headlines
The Sarasota Police Department has named 24-year-old Kyle Riley as a suspect in a sexual battery case with a 14-year-old victim.
+Turtle disorientations higher than usual
Mote scientists have documented 23 adult female disorientations during the first two-and-a-half months of nesting season.
+City Commission approves Laurel Park Overlay District
The City Commission approved the creation of the overlay district, which will require public hearings before the approval of nearby large developments.
Black Tie
+A Midsummer's Night Wish
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- Jan
29 LBK Chamber Annual Awards Luncheon
11:30 am - 1:30 pm - Jan
30 AJC's 2015 Winter Lunch & Learn
11:30 am - 1:30 pm - Feb
8 Sarasota Music Half Marathon
7:00 am - 6:00 am - Feb
12 Longboat Key Chamber of Commerce Networking Luncheon
11:30 am - 1:30 pm
Key gets high five from Krauthammer
The night before he was scheduled to speak at the Ringling College Library Association Town Hall lecture, Fox News commentator and syndicated columnist Dr. Charles Krauthammer arrived late Monday night, Jan. 12, for his stay at the Inn on the Beach Resort at the Longboat Key Club. -
OSU victory a gem for Holbrook
Karen Holbrook wore red and black to the Jan. 14 Longboat Key Rotary Club meeting. -
Paul Glosser takes turning 85 in stride
Longboat Key resident Paul Glosser isn't letting his 85th birthday slow him down.


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text:
Industry confidence down again
The Thai Industries Sentiment Index (TISI) was down from 93.5 in March to 92.9 in April, Payungsak Chartsuthipol, chairman of the Federation of Thai Industries (FTI), said on Friday.
- Published: 17/05/2013 at 01:46 PM
- Newspaper section: breakingnews
Industry confidence was down for the fourth straight month, and the fact the index remains below the 100 level shows low confidence overall in the industry sector, the FTI chief said.
Mr Payungsak attributed the drop in industry confidence to manufacturers' concerns about the baht's strength when compared to other currencies in the region, which affected the export sector, and global economic fluctuations, all causing them problems when taking orders.
In addition, manufacturers had begun to import cheaper raw materials, turning away from higher priced domestic supplies. This affected the supply chain of the country's upstream industry. At the same time there were no clear assistance measures from the state, he said.
Industry confidence for the next three months was also down, to 99.1 from 99.3 reported in March, on the back of declining overall orders, sales outlook, output and business performance.
The manufacturers were most concerned about the foreign exchange rate, followed by the global economic situation, oil prices, internal political conflict and loan rates.
They wanted the government to step in to stabilise the value of the Thai currency to stop it from strengthening more than those of other countries in the region, particularly Thailand's competitors.
Manufacturers also wanted the state to provide training courses for small and medium enterprises (SMEs) on the use of financial tools to prevent risk from the exchange rate, continue to boost domestic consumption, and find financial sources to provide low interest loans to ensure SMEs have sufficient liquidity, Mr Payungsak said.
About the author
- Writer: Online Reporters
- Position: Online Reporters


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Republicans outline agenda for legislative session
Virginia Gov. Bob McDonnell and other Republican leaders want the General Assembly to cut government spending and foster economic development during the legislative session that begins Wednesday. At a press conference Tuesday, GOP officials outlined seven issues for the 2011 General Assembly. They dubbed their agenda "smaller government, stronger economy." "This is a positive, forward-looking agenda that recognizes the need for a smaller, smarter state government but also commits to job-creating efforts in the areas of transportation, economic development and higher education," McDonnell said. The Republicans said their joint agenda calls for: • Fiscal responsibility and restructuring, including spending cuts, a hiring freeze and changes in the Virginia Retirement System • Job creation and economic development • Higher education reforms and reinvestment • More funding for transportation • Protection of private property rights • Passage of a constitutional "repeal amendment" allowing states to federal laws for policy reasons • Protection of Virginia's right-to-work law by mandating that union elections be conducted by secret ballot While all those points are important, McDonnell said he believes the economy is "the first and foremost issue facing Virginia with 285,000 Virginians unemployed." Lt. Gov. Bill Bolling said the GOP's economic initiatives would help attract jobs to Virginia and support employers in bio-sciences, energy technology and communications. He called for legislation to provide $54 million in grants and incentives for job creation. Bolling also wants the General Assembly to approve a $25 million program to help small technology companies in Virginia. Another focus is renewable energy. Bolling said the Republicans' proposed Clean Energy Manufacturing Incentive Grant program would give financial assistance to companies that supply renewable and nuclear energy. "It's an important part of our overall effort to achieve the goal of making Virginia the East Coast's energy leader," Bolling said. McDonnell plans on continuing state budget cuts with permanent hiring freezes to save about $25 million. He said he wants to reduce funding for areas that are not government priorities, such as public broadcasting. The governor also proposed eliminating and reducing various vacant state positions, boards and commissions. Attorney General Ken Cuccinelli addressed private property rights of individuals. He said governmental entities should have to meet strict requirements before seizing a person's property. House Speaker William Howell of Fredericksburg touted the proposed "repeal amendment" to the U.S. Constitution. It would allow states to overturn a federal law by a two-thirds vote. "It would have the important effect of deterring further expansion of federal power at the expense of the sovereignty of the people and of the several states. This resolution is timely, practical and non-partisan," Howell said. Sen. Thomas Norment, R-Williamsburg, laid out the Republicans' plans for higher education reform. Norment, the Senate Republican leader, called for accessibility and affordability to ensure that Virginia students have access to top-tier universities without having to worry about financial restrictions. The General Assembly convenes at noon Wednesday for a 46-day session. On Wednesday night, McDonnell will deliver his State of the Commonwealth Address to a joint meeting of the House and Senate. In the speech, McDonnell said he plans to discuss Medicaid reform, energy policy, education and other issues. |
'Secret Keeper Girl - Crazy Hair Tour' returning to West End Assembly of God
Hundreds of 'tweens' and their moms will attend the Secret Keeper Girl Crazy Hair Tour at West End Assembly of God on Jan. 22 at 6:30 p.m., a popular Bible-based tour geared toward building and strengthening relationships between mothers and their daughters (typically ages 8 to 12).
The event will feature a full fashion show, oversized balloon sculptures and confetti cannons – all in the name of inner beauty, Biblical modesty and vibrant purity. > Read more.
OutRVA, 'Say I Do!' to give away all-expenses paid wedding at Lewis Ginter
Citizen Staff Reports 01/15/2015
OutRVA and Say I Do! have collaborated to offer LGBT couples an opportunity to win an all-expenses-paid wedding at Lewis Ginter Botanical Garden's Robins Tea House on March 7.
In September, Richmond Region Tourism launched OutRVA, a campaign designed to show people Richmond's strong LGBT community and highlight the area as a travel destination.
The winning couple will say "I do" in a ceremony coordinated by event designer and floral artist Casey Godlove of Strawberry Fields Flowers & Gifts and marriage concierge, Ayana Obika of All About The Journey. The couple will receive wardrobe and styling, a custom wedding cake, florals, an overnight stay at the Linden Row Inn (including a suite on the day of the wedding for preparation), and a post-wedding brunch at the Hilton Garden Inn on Sunday, March 8. > Read more.
No CVWMA collection delays for Lee-Jackson, MLK holidays
Citizen Staff Reports 01/12/2015
CVWMA residential recycling and trash collections will continue as regularly scheduled for the Lee-Jackson (Jan. 16) and Martin Luther King, Jr. Day (Jan. 19) holidays. Residential recycling collections on Friday, Jan. 16 and the week of Jan 19-23 will take place on normal collection day. Residents should place recycling container(s) out for pick-up by 7 a.m. on their regular scheduled collection day. > Read more.
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CAT Theatre announces auditions for 'Quartet'
CAT Theatre will hold auditions for Quartet on Saturday, Feb. 21, from 4 p.m. to 7 p.m., and Sunday, Feb. 22, from 3 p.m. to 6 p.m. Auditions will be held at the theatre, located at 319 N. Wilkinson Road in Richmond. Quartet will run May 22 through June 6 and will close out CAT's 51st season.
Director Laurie Follmer is seeking two males, ages 50-70 and two females ages 50-70. British accents are required for roles and are requested for auditions. There is no actual singing in the show. Singing ability and experience is not a requirement. Audition sides are available at http://www.cattheatre.com on the Audition Page. > Read more.
Restaurant watch
Find out how your favorite dining establishments fared during their most recent inspections by the Virginia Department of Health. > Read more.
Weekend Top 10
It's off to the theatre – this weekend in Henrico! "Two on Tap" at CACGA brings audiences back in time to an era when couples like Fred & Ginger and Mickey & Judy filled the silver screen. CAT Theatre's production of "Book of Days" begins tonight and runs through Feb. 7. Fans of the Emmy Award-winning 1970s Saturday morning cartoon "Schoolhouse Rock!" will love the live adaptation at the University of Richmond on Sunday. The Shanghai Quartet will also perform at the University of Richmond. For all our top picks this weekend, click here! > Read more.
Law would let Dominion hike electric bills
Health secretary urges Medicaid expansion
Bill would ease prescription hassles
Small fire extinguished at Mondelez factory
O'Bannon to seek re-election as supervisor
- More News
Print Edition
Jan. 22, 2015
Click here to read the print edition.Entertainment
CAT Theatre announces auditions for 'Quartet'
Restaurant watch
Weekend Top 10
Environmental Film Festival films to be screened at Tuckahoe Library
Weekend Top 10
- More Entertainment
Obituary – Charles Wilbur "Bill" Emery
Obituary – Susan O'Brien Dempsey
Obituary – Joseph R. Beckman
- More Obituaries
'Secret Keeper Girl - Crazy Hair Tour' returning to West End Assembly of God
OutRVA, 'Say I Do!' to give away all-expenses paid wedding at Lewis Ginter
No CVWMA collection delays for Lee-Jackson, MLK holidays
- More Community
Bored senseless
Announcing Henrico Restaurant Week
An actual holiday spirit
- More Opinions
Monument City Classic volleyball tournament returns to town this weekend
Richmond Strikers form girls lacrosse program
Virginia fisherman wins James River event in Henrico
- More Sports
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The gift of love
By Samantha Daniels | Photography by Photoplay Photography
Posted: Tuesday, Oct. 18, 2011
Some friendships last a lifetime Aki Wallace and LeJay Parker are betting on it. After meeting on the campus of Winston-Salem State University, the two became an inseparable (platonic) pair. They spent the next three years as close friends but the possibility of something more wasnt lost on LeJay. He would always joke about us being together and dating, recalls Aki. Eventually, his joking became reality.
The couple dated as they went through graduate school and started their careers. On Christmas Day in 2009, Aki and Parker were at Akis family home. Both of their families were gathered for Christmas dinner and fellowship. When it was time to open presents, Aki had a little something extra. The whole room gathered around as she opened her final gift. It was a pair of leather gloves and a little white box. Before she could say a word, she heard LeJay say her name. He had the box and ring in his hand and before he even kneeled down I started crying, says Aki. Surrounded by their family on Christmas, Aki and LeJay had the best gift of all. For the big day, Aki and LeJay knew they wanted a relaxing day that all their friends and family could enjoy. As a graphic designer, Aki designed all the graphic elements of her wedding from invitations to programs. Sadly, during the planning process, Aki lost her mother to breast cancer. It was difficult to continue moving forward after losing my mom, but we knew she would want nothing more than for us to stay strong, says Aki. Aki wanted to try to incorporate her mother into her wedding day as much as she could. On a hot, June day under the Carolina sun, Aki and LeJay were joined in holy matrimony. Aki wore her mothers engagement ring and band on her right hand during the ceremony. [My mom] enjoyed little things like that and I knew she would appreciate it, says Aki. The wedding was officiated by Akis father, Reverend Michael E. Wallace, which was a special element of the ceremony.Soon the wedding transitioned from outside ceremony to inside party. The Magnolia Room in Rock Hill proved to be the perfect reception area. The hardwood floors and beautiful light fixtures served as a foundation for the rest of the décor provided by Classic Party Rentals. The centerpieces for the tables featured orchids submerged in water. Everything was kept simple and elegant. When recalling her favorite moment of the day, Aki says it was, just looking around and seeing our families together and having a great time. Wedding consultant Ivy Honeycutt of The Silk Veil made sure the day went off without a hitch. Aki and LeJay were able to enjoy every moment. As one large wedding favor, Aki and Lejay made a donation to the American Cancer Society in honor of Akis mother, as well as other lost family members. As the night came to a close, Photoplay Photography captured final moments. Mr. and Mrs. Parker were whisked off to begin their new life together.After a relaxing honeymoon in Siesta Keys, Florida, the happy couple is now enjoying the married life. Their loving family members have been hinting at children but Aki insists, We want to wait awhile before we have little Parkers!Featured Vendors:PhotographyPhotoplay Photography
www.photoplaync.comReception location
The Magnolia Room
www.magnoliaroom.comRental provider
Classic Party Rentals
www.classicpartyrentals.comWedding consultant
The Silk Veil Events by Ivy
www.thesilkveil.com Wedding night hotel
Embassy Suites Hotel Charlotte
www.escharlottecatering.comContinue reading real wedding stories! Up next: 'All in good time'
The Charlotte Observer welcomes your comments on news of the day. The more voices engaged in conversation, the better for us all, but do keep it civil. Please refrain from profanity, obscenity, spam, name-calling or attacking others for their views.
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Find a copy online
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bvbr.bib-bvb.de Inhaltsverzeichnis
Find a copy in the library
Finding libraries that hold this item...
Genre/Form: | Aufsatzsammlung History |
Material Type: | Internet resource |
Document Type: | Book, Internet Resource |
All Authors / Contributors: |
Francisco Bethencourt; Diogo Ramada Curto |
OCLC Number: | 67361089 |
Description: | xx, 536 p. : ill., maps ; 24 cm. |
Contents: | The economy of the Portuguese Empire / Stuart B. Schwartz -- Costs and financial trends in the Portuguese Empire, 1415--1822 / Jorge M. Pedreira -- Markets and merchant communities in the Indian Ocean : locating the Portuguese / Michael N. Pearson-- The economic network of Portugal's Atlantic world (translated by Marguerite Itamar Harrison) / Luis Felipe de Alencastro -- The Portuguese in Africa / John K. Thornton -- Patterns of settlement in the Portuguese Empire, 1400-1800 / A. J. R. Russell-Wood -- Political configurations and local powers / Francisco Bethencourt -- Ecclesiastical structures and religious action / Isabel dos Guimarães Sá -- Portuguese expansion, 1400-1800 : encounters, negotiations, and interactions / Anthony Disney -- Portuguese imperial and colonial culture / Diogo Ramada Curto -- Language and literature in the Portuguese Empire / Luís de Sousa Rebelo -- The expansion and the arts : transfers, contaminations, innovations / Luís de Moura Sobral -- Science and technology in Portuguese navigation : the idea of experience in the sixteenth century (translated by Neil Safier) / Francisco Contente Domingues -- Portuguese expansion in a global context / Felipe Fernández-Armesto. |
Responsibility: | edited by Francisco Bethencourt, Diogo Ramada Curto. |
More information: |
Publisher Synopsis
"The collection will be of interest to both general readers and students." -Shantha Hariharan, International History of Maritime History "...this is a well-balanced book, whose articles fulfill the goals set in the introduction. Its value goes beyond the general information it provides about Portuguese expansion, offering excellent insight and an innovative framework for further research on this theme." -Catia Antunes, H-Atlantic this theme. "The field of early modern Portuguese global history has long lacked a solid one-volume overview in English." -Timothy J. Coates, Journal of World History "Portuguese Oceanic Expansion, 1400-1800 has fulfilled the aims of the editors and writers very well. it provides a well-balanced, modern, and interdisciplinary volume that is open to a diversity of opinions and approaches. Personally, I would like to extend warm thanks to the authors and editors of this volume for their valuable work." Canadian Journal of History, Jakub Basista, Jagiellonian University-Poland Read more...
Similar Items
Related Subjects:(17)
- Portugal -- History -- Period of discoveries, 1385-1580.
- Portugal -- History -- Modern, 1580-
- Portugal -- Territorial expansion.
- Portugal -- Colonies -- History.
- Portugal -- Civilization.
- Portugal -- Histoire -- 1385-1580 (Période des découvertes)
- Portugal -- Histoire -- 1580-
- Portugal -- Expansion territoriale.
- Portugal -- Colonies -- Histoire.
- Portugal -- Civilisation.
- Kolonialismus.
- Expansionspolitik.
- Außereuropäische Länder.
- Portugal.
- Civilization.
- Colonies.
- Territorial expansion.
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What does JHB mean in Companies & Firms?
This page is about the meanings of the acronym/abbreviation/shorthand JHB in the Business field in general and in the Companies & Firms terminology in particular.
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Use the citation below to add this abbreviation to your bibliography:
"JHB." Abbreviations.com. STANDS4 LLC, 2015. Web. 28 Jan. 2015. <http://www.abbreviations.com/term/141684>.
JHB also stands for:
- J. H. Belcher, C. P. A., P. C.
- James H. Burghart
- Johann Heinrich Bernhard
- Johannesburg, South Africa
- Johor Bahru, Malaysia
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The Enchanted Cave 2
Delve into a strange cave with a seemingly endless supply of treasure, strategically choos
4.36 / 5.00 34,803 ViewsGhostbusters B.I.P.
COMPLETE edition of the interactive "choose next panel" comic
4.09 / 5.00 12,911 ViewsDesktop versions are available from this link:
http://robotacid.com/flas h/ending/
Android and iOS versions are also available.
Awesome game, makes you think about whats going to happen next. It also makes sure you don't want do get hit. Although, it could use a bit more of sounds other than the bashing, it gets boring after awhile of that.


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Publications (26)121.23 Total impact
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ABSTRACT: CAPN3/p94/calpain-3, a calpain protease family member predominantly expressed in skeletal muscle, possesses unusually rapid and exhaustive autolytic activity. Mutations in the human CAPN3 gene impairing its protease functions cause limb-girdle muscular dystrophy type 2A (LGMD2A); yet, the connection between CAPN3's autolytic activity and the enzyme's function in vivo remain unclear. Here, we demonstrated that CAPN3 protease activity was reconstituted by intermolecular complementation (iMOC) between its two autolytic fragments. Furthermore, the activity of full-length CAPN3 active-site mutants was surprisingly rescued through iMOC with autolytic fragments containing WT amino acid sequences. These results provide evidence that WT CAPN3 can be formed by the iMOC of two different complementary CAPN3 mutants. The finding of iMOC-mediated restoration of calpain activity indicates a novel mechanism for the genotype-phenotype links in LGMD2A.Proceedings of the National Academy of Sciences 12/2014; · 9.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Calpains comprise a superfamily of Ca(2+) -regulated cysteine proteases that are indispensable for the regulation of various cellular functions. Of these, the mammalian μ- and m-calpains are the best characterized isoforms. They are ubiquitously expressed and form heterodimers consisting of a distinct 80-kDa catalytic subunit (CAPN1 for μ-calpain and CAPN2 for m-calpain) and a common 30-kDa regulatory subunit (CAPNS1). To date, various expression systems have been developed for producing recombinant calpains for structural and functional studies; however, no low-cost, simple and efficient bacterial expression system for μ-calpain has been available, because the protein forms aggregates. Here, we established an efficient method for producing active recombinant human μ-calpain using an Escherichia coli expression system. This was achieved by co-expressing CAPN1 and CAPNS1 lacking the N-terminal Gly-rich domain (CAPNS1ΔGR) in the SoluBL21 strain. From 1 L of E. coli culture, over 2 and 6 mg, respectively, of μ-calpain and its active-site mutant μ-calpain:C115S (CAPN1:C115S+CAPNS1ΔGR) were purified by two successive column chromatographies. Compared to the native enzyme, the purified μ-calpain showed almost identical properties, demonstrating its suitability for use in structural and functional studies. This is the first report of the bacterial expression and the simple and efficient purification of active recombinant μ-calpain.Genes to Cells 06/2013; · 2.73 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: CAPN3/p94/calpain-3 is a skeletal muscle-specific member of the calpain protease family. Multiple muscle-cell functions have been reported for CAPN3, and mutations in this protease cause limb-girdle muscular dystrophy type 2A. Little is known about the molecular mechanism(s) that allow CAPN3 to be so multifunctional. One hypothesis is that the very rapid and exhaustive autolytic activity of CAPN3 needs to be suppressed by dynamic molecular interactions for specific periods of time. The previously identified interaction between CAPN3 and connectin/titin, a giant molecule in muscle sarcomeres, supports this assumption; however, the regulatory mechanisms of non-sarcomere-associated CAPN3 are unknown. Here, we report that a novel CAPN3-binding protein, PLEIAD (Platform element for inhibition of autolytic degradation, originally called SIMC1/C5orf25), suppresses the protease activity of CAPN3. Database analyses showed that PLEIAD homologs, like CAPN3 homologs, are evolutionarily conserved in vertebrates. Furthermore, we found that PLEIAD also interacts with CTBP1, a transcriptional co-regulator, and CTBP1 is proteolyzed in COS7 cells expressing CAPN3. The identified cleavage sites in CTBP1 suggested that it undergoes functional modification upon its proteolysis by CAPN3, as well as by conventional calpains. These results indicate that PLEIAD can shift its major function from CAPN3 suppression to CAPN3-substrate recruitment, depending on the cellular context. Taken together, our data suggest that PLEIAD is a novel regulatory scaffold for CAPN3, as reflected in its name.Journal of Molecular Biology 05/2013; · 3.91 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Calpain belongs to the superfamily of Ca(2+)-regulated cysteine proteases, which are indispensable to the regulation of various cellular functions. Of the 15 mammalian calpain isoforms, µ- and m-calpains are the best characterized. Both µ- and m-calpain are ubiquitously expressed and exist as heterodimers, containing a distinct 80-kDa catalytic subunit (CAPN1 and CAPN2, respectively) and the common, 30-kDa regulatory subunit (CAPNS1). To date, various expression systems have been developed for producing recombinant calpains for use in structural and physiological studies, however Escherichia coli systems have proven incompatible with large-scale preparation of calpain, with the exception of rat m-calpain. Here, we have established a highly efficient method to purify active recombinant human m-calpain using an E. coli expression system at low temperature (22°C). This was achieved by co-expressing CAPN2 with a C-terminal histidine-tag, and CAPNS1, lacking the first Gly-repeated region at the N-terminal. After three sequential passes through a chromatographic column, ~5 mg of human m-calpain was homogenously purified from 1 l of E. coli culture. Proteins were stable for several months. This is the first report of efficient, large-scale purification of recombinant human m-calpain using an E. coli expression system.Journal of Biochemistry 01/2012; 151(4):417-22. · 3.07 Impact Factor - Neuromuscular Disorders 10/2010; 20(9):598-599. · 3.13 Impact Factor
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ABSTRACT: Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease that is caused by mutations in the calpain 3 gene (CAPN3), which encodes the skeletal muscle-specific calpain, calpain 3 (also known as p94). However, the precise mechanism by which p94 functions in the pathogenesis of this disease remains unclear. Here, using p94 knockin mice (termed herein p94KI mice) in which endogenous p94 was replaced with a proteolytically inactive but structurally intact p94:C129S mutant protein, we have demonstrated that stretch-dependent p94 distribution in sarcomeres plays a crucial role in the pathogenesis of LGMD2A. The p94KI mice developed a progressive muscular dystrophy, which was exacerbated by exercise. The exercise-induced muscle degeneration in p94KI mice was associated with an inefficient redistribution of p94:C129S in stretched sarcomeres. Furthermore, the p94KI mice showed impaired adaptation to physical stress, which was accompanied by compromised upregulation of muscle ankyrin-repeat protein-2 and hsp upon exercise. These findings indicate that the stretch-induced dynamic redistribution of p94 is dependent on its protease activity and essential to protect muscle from degeneration, particularly under conditions of physical stress. Furthermore, our data provide direct evidence that loss of p94 protease activity can result in LGMD2A and molecular insight into how this could occur.The Journal of clinical investigation 08/2010; 120(8):2672-83. · 15.39 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Calpains constitute a superfamily of Ca2+-dependent cysteine proteases, indispensable for various cellular processes. Among the 15 mammalian calpains, calpain 8/nCL-2 and calpain 9/nCL-4 are predominantly expressed in the gastrointestinal tract and are restricted to the gastric surface mucus (pit) cells in the stomach. Possible functions reported for calpain 8 are in vesicle trafficking between ER and Golgi, and calpain 9 are implicated in suppressing tumorigenesis. These highlight that calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. However, there is no direct evidence implicating calpain 8 or 9 in human disease, and their properties and physiological functions are currently unknown. To address their physiological roles, we analyzed mice with mutations in the genes for these calpains, Capn8 and Capn9. Capn8(-/-) and Capn9(-/-) mice were fertile, and their gastric mucosae appeared normal. However, both mice were susceptible to gastric mucosal injury induced by ethanol administration. Moreover, the Capn8(-/-) stomach showed significant decreases in both calpains 9 and 8, and the same was true for Capn9(-/-). Consistent with this finding, in the wild-type stomach, calpains 8 and 9 formed a complex we termed "G-calpain," in which both were essential for activity. This is the first example of a "hybrid" calpain complex. To address the physiological relevance of the calpain 8 proteolytic activity, we generated calpain 8:C105S "knock-in" (Capn8(CS/CS)) mice, which expressed a proteolytically inactive, but structurally intact, calpain 8. Although, unlike the Capn8(-/-) stomach, that of the Capn8(CS/CS) mice expressed a stable and active calpain 9, the mice were susceptible to ethanol-induced gastric injury. These results provide the first evidence that both of the gastrointestinal-tract-specific calpains are essential for gastric mucosal defense, and they point to G-calpain as a potential target for gastropathies caused by external stresses.PLoS Genetics 07/2010; 6(7):e1001040. · 8.17 Impact Factor - Journal of Allergy and Clinical Immunology 02/2010; 125(2). · 11.25 Impact Factor
Article: Selective down-regulation of Th2 cytokines by C-terminal binding protein 2 in human T cells.
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ABSTRACT: Among several C-terminal binding proteins (CtBPs), friend of GATA (FOG) has been implicated in the down-regulation of GATA-3-mediated Th2 cell differentiation. Here we investigated the role of CtBP2 in Th1 and Th2 cytokine expression in human T cells. CtBP2 was introduced into human peripheral CD4+ T cells by a lentiviral transduction system. Subsequently, the expression of Th1 and Th2 cytokine mRNA was determined by quantitative real-time RT-PCR. CtBP2 significantly suppressed stimulation-induced expression of IL-4, IL-5 and IL-13 in human T cells. However, IFN-gamma expression was not affected by the introduction of CtBP2. CtBP2 selectively down-regulates Th2 cytokines, therefore it is a potential target for the treatment of allergic diseases.International Archives of Allergy and Immunology 01/2010; 152 Suppl 1:18-21. · 2.25 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The functional role of C-terminal binding protein (CtBP)1, a transcriptional corepressor, in Th1 and Th2 cytokine expression in human T cells was investigated. Upon introduction of CtBP1 by lentiviral transduction system, IL-4 synthesis was suppressed but IFN-gamma was weakly up-regulated in human CD4(+) T cells. In contrast, a reduction of endogenously expressed CtBP1 in Jurkat T cells using RNAi technology selectively augmented IL-4 expression. The down-regulation of IL-4 by CtBP1 was achieved at the level of gene transcription. Deletion mutation analysis revealed that N-terminal approximately 200 amino acid and C-terminal approximately 50 amino acid residues are participated in CtBP1-mediated suppression of IL-4 expression. CtBP1 expressed in human CD4(+) T cells crucially contribute to Th1/Th2 differentiation via selective down-regulation of IL-4 synthesis.Biochemical and Biophysical Research Communications 06/2009; 382(2):326-30. · 2.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Regardless of T(H)1/T(H)2 theory, CD4(+) T cells of patients with allergic asthma, a typical T(H)2 disease, and those of healthy subjects expressed equivalent levels of IFN-gamma, even though T(H)2 cytokines were significantly upregulated in asthmatic patients. The mechanisms underlying distorted T(H)2 cell polarization in human T cells were elucidated. Cytokine-producing activity and the expression of T(H)1/T(H)2-specific transcription factors in naïve, T(H)1/T(H)2, or both CD4(+) T cells derived from human peripheral and cord blood were comparatively analyzed. The mechanisms of the differential expression of T-box 21 transcription factor (T-bet) in the cells were assessed by determining the chromatin accessibility at the TBX21 gene. The functional roles of T-bet and other transcription factors in human T(H)1/T(H)2 differentiation were further investigated. T(H)2 cells derived from naive CD4(+) T cells in peripheral blood but not in cord blood produced IFN-gamma. T-bet was expressed in peripheral, but not cord blood, resting naive T cells. Consistently, the accessibility at the proximal TBX21 gene promoter in peripheral naive T cells was higher than that in cord blood naive T cells. IFN-gamma-producing activity was induced in T(H)2-differentiated cord blood T cells by means of ectopic expression of T-bet. In addition, a reduction of T-bet in peripheral T cells suppressed IFN-gamma production. T-bet not only upregulated IFN-gamma but also downregulated IL-4 and IL-13 gene transcription, independently of the modification of T(H)1/T(H)2 balance. The expression of T-bet at a naive stage is crucial for the development of IFN-gamma-producing T cells in human peripheral blood, even in T(H)2-related diseases.The Journal of allergy and clinical immunology 05/2009; 123(4):813-23.e3. · 12.05 Impact Factor - Journal of Proteomics & Bioinformatics 07/2008;
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ABSTRACT: p94/calpain 3 is a skeletal muscle-specific Ca(2+)-regulated cysteine protease (calpain), and genetic loss of p94 protease activity causes muscular dystrophy (calpainopathy). In addition, a small in-frame deletion in the N2A region of connectin/titin that impairs p94-connectin interaction causes a severe muscular dystrophy (mdm) in mice. Since p94 via its interaction with the N2A and M-line regions of connectin becomes part of the connectin filament system that serves as a molecular scaffold for the myofibril, it has been proposed that structural and functional integrity of the p94-connectin complex is essential for health and maintenance of myocytes. In this study, we have surveyed the interactions made by p94 and connectin N2A inside COS7 cells. This revealed that p94 binds to connectin at multiple sites, including newly identified loci in the N2A and PEVK regions of connectin. Functionally, p94-N2A interactions suppress p94 autolysis and protected connectin from proteolysis. The connectin N2A region also contains a binding site for the muscle ankyrin repeat proteins (MARPs), a protein family involved in the cellular stress responses. MARP2/Ankrd2 competed with p94 for binding to connectin and was also proteolyzed by p94. Intriguingly, a connectin N2A fragment with the mdm deletion possessed enhanced resistance to proteases, including p94, and its interaction with MARPs was weakened. Our data support a model in which MARP2-p94 signaling converges within the N2A connectin segment and the mdm deletion disrupts their coordination. These results also implicate the dynamic nature of connectin molecule as a regulatory scaffold of p94 functions.Journal of Biological Chemistry 06/2008; 283(21):14801-14. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: During pathophysiological muscle wasting, a family of ubiquitin ligases, including muscle RING-finger protein-1 (MuRF1), has been proposed to trigger muscle protein degradation via ubiquitination. Here, we characterized skeletal muscles from wild-type (WT) and MuRF1 knockout (KO) mice under amino acid (AA) deprivation as a model for physiological protein degradation, where skeletal muscles altruistically waste themselves to provide AAs to other organs. When WT and MuRF1 KO mice were fed a diet lacking AA, MuRF1 KO mice were less susceptible to muscle wasting, for both myocardium and skeletal muscles. Under AA depletion, WT mice had reduced muscle protein synthesis, while MuRF1 KO mice maintained nonphysiologically elevated levels of skeletal muscle protein de novo synthesis. Consistent with a role of MuRF1 for muscle protein turnover during starvation, the concentrations of essential AAs, especially branched-chain AAs, in the blood plasma significantly decreased in MuRF1 KO mice under AA deprivation. To clarify the molecular roles of MuRF1 for muscle metabolism during wasting, we searched for MuRF1-associated proteins using pull-down assays and mass spectrometry. Muscle-type creatine kinase (M-CK), an essential enzyme for energy metabolism, was identified among the interacting proteins. Coexpression studies revealed that M-CK interacts with the central regions of MuRF1 including its B-box domain and that MuRF1 ubiquitinates M-CK, which triggers the degradation of M-CK via proteasomes. Consistent with MuRF1's role of adjusting CK activities in skeletal muscles by regulating its turnover in vivo, we found that CK levels were significantly higher in the MuRF1 KO mice than in WT mice. Glucocorticoid modulatory element binding protein-1 and 3-hydroxyisobutyrate dehydrogenase, previously identified as potential MuRF1-interacting proteins, were also ubiquitinated MuRF1-dependently. Taken together, these data suggest that, in a multifaceted manner, MuRF1 participates in the regulation of AA metabolism, including the control of free AAs and their supply to other organs under catabolic conditions, and in the regulation of ATP synthesis under metabolic-stress conditions where MuRF1 expression is induced.Journal of Molecular Biology 04/2008; 376(5):1224-36. · 3.91 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The NFAT family transcription factors play crucial roles in immunological and other biological events; however, the functional differences among NFAT members have not been fully elucidated. This study investigated the relative contribution of NFATc2 and NFATc1 to the transactivation of cytokine genes in T cells. Ectopic expression of NFATc2 but not NFATc1, especially its short isoform, enhanced TNF-alpha synthesis in human T cells at the gene transcription level, whereas both NFATs augmented IL-2 expression. In addition, a reduction of the shortest NFATc1 isoform using RNA interference technology failed to suppress TNF-alpha expression. The promoter/enhancer activity of the NFAT-binding site in the TNF-alpha gene was up-regulated by NFATc2 but not by NFATc1, whereas both NFATs associated similarly with this region. A study of mRNA expression using NFATc2/NFATc1 chimeric molecules revealed that the enhancing activity of NFAT on the TNF-alpha gene was lost by truncation of its C-terminal transactivation domain. In addition, this domain derived from NFATc2 behaved as a dominant negative against the NFAT site in TNF-alpha promoter-dependent transcriptional activity in T cells. We conclude that the C-terminal transactivation domain in NFAT is crucial for TNF-alpha gene expression in human T cells.The Journal of Immunology 02/2008; 180(1):319-26. · 5.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Downregulation of a Th2 cytokine, IL-4, by a Th1-specific transcription factor, T-bet, has been demonstrated. However, the regulatory role of T-bet in another Th2 cytokine, IL-13, is not fully delineated. IL-13 mRNA expression in Jurkat cells was examined by quantitative RT-PCR, while the transcriptional activity of 5'-flanking region in the IL-13 gene encompassing -1077 to +49 was investigated by fluorescence-based promoter reporter assay. The effect of T-bet was investigated by transfection of the cells with the T-bet expression vector. Stimulation with phorbol ester plus Ca2+ ionophore clearly induced IL-13 gene transcription in Jurkat cells. Ectopically expressed T-bet significantly suppressed the inducible mRNA expression and promoter activity of IL-13. IL-13 expression was downregulated by T-bet at the level of gene transcription, independently of the modulation of Th1/Th2 balance. T-bet is the potential key factor in the development of Th1/Th2-related diseases.International Archives of Allergy and Immunology 02/2008; 146 Suppl 1:33-5. · 2.25 Impact Factor - Journal of Proteomics & Bioinformatics 01/2008;
- The Journal of Immunology 12/2007; 180(1). · 5.36 Impact Factor
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ABSTRACT: Calpains constitute a family of intracellular Ca(2+)-regulated cysteine proteases that are indispensable in the regulation of a wide variety of cellular functions. The improper activation of calpain causes lethality or various disorders, such as muscular dystrophies and tumor formation. nCL-2/calpain 8 is predominantly expressed in the stomach, where it appears to be involved in membrane trafficking in the gastric surface mucus cells (pit cells). Although the primary structure of nCL-2 is quite similar to that of the ubiquitous m-calpain large subunit, the enzymatic properties of nCL-2 have never been reported. Here, to characterize nCL-2, the recombinant protein was prepared using an Escherichia coli expression system and purified to homogeneity. nCL-2 was stably produced as a soluble and active enzyme without the conventional calpain regulatory subunit (30K). Purified nCL-2 showed Ca(2+)-dependent activity, with half-maximal activity at about 0.3 mM Ca(2+), similar to that of m-calpain, whereas its optimal pH and temperature were comparatively low. Immunoprecipitation analysis revealed that nCL-2 exists in both monomeric and homo-oligomeric forms, but not as a heterodimer with 30K or 30K-2, and that the oligomerization occurs through domains other than the 5EF-hand domain IV, most probably through domain III, suggesting a novel regulatory system for nCL-2.Journal of Biological Chemistry 10/2007; 282(38):27847-56. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The effects of selective CC chemokine receptor (CCR)-3 antagonists on antigen-induced leukocyte accumulation in the lungs of mice adoptively transferred with in vitro-differentiated T(h)1 and T(h)2 were investigated. Inhalation of antigen by mice injected with T(h)1 and T(h)2 initiated the migration of T cells themselves into the lungs. Subsequently, neutrophils massively accumulated in T(h)1-transferred mice, whereas eosinophil infiltration was specifically induced by T(h)2. CCR3 antagonists, SB-297006 and/or SB-328437, suppressed antigen-induced accumulation of T(h)2 as well as eosinophils in the lungs, whereas they failed to affect T(h)1-mediated airway inflammation. Not only T(h)2 and eosinophil infiltration but also cellular mobilization in T(h)1-transferred mice was attenuated by an anti-CC chemokine ligand-11 antibody. CCR3 antagonists reduced chemokine production in the lungs of mice transferred with T(h)2 but not T(h)1, suggesting that down-regulation of chemokine synthesis is involved in the selective inhibition of T(h)2-mediated eosinophil infiltration by CCR3 antagonists.International Immunology 09/2007; 19(8):913-21. · 3.18 Impact Factor
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your welcome babes you should post more pics so we can admire you some more j/p you know your an
another pic on the second
Baby you just keep on sending the pics... and we'd keep squirting over it...LOL... nah just playing... blessings to the beauty!
you sick child but yuh still meh boy....oh yeh i know that pic you look sweet there but i rather this one.... l8rz
ah waiting to see ah pic of you


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Tech Helproom
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Computer build, can you please help me?
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Posted February 20, 2013 at 7:32PM
Processor: i5-3570K 3.4GHz Quad-Core £161.99
CPU Cooler: Cooler Master Hyper 212 EVO 82.9 CFM Sleeve Bearing £24.99
Motherboard: Gigabyte GA-Z77X-UD3H ATX LGA1155 £117.99 Shipping Fee: £1.99
Memory: Corsair Vengeance 8GB (2 x 4GB) DDR3-1600 £38.99
Storage: Western Digital RE3 1TB 3.5" 7200RPM £44.34
Video Card: Asus GeForce GTX 660 Ti 2GB £236.09
Case: Corsair 300R ATX Mid Tower £59.99
Power Supply: Antec 620W ATX12V / EPS12V £48.61
Optical Drive: Lite-On iHAS124-04 DVD/CD Writer £12.98
Operating System: Microsoft Windows 7 Home Premium SP1 (OEM) (64-bit) £65.99
Total: £813.95
Can you please help me be more efficient through price and performance? My max budget is £820.
I'm a gamer, I would love outstanding FPS. However I also do multimedia processing, graphic design - not intensive stuff though.
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Posted February 20, 2013 at 8:47PM
Almost 40 views and still no replies?
Shameless self bump...
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Posted February 21, 2013 at 9:52AM
Nothing wrong with your component selection though I think a small SSD for operating system and programs would be an excellent addition.
You can save a bit of money by dropping the i5-3570K to the non K version. The K version means that the multiplier is unlocked which allows you to overclock/underclock the CPU.So not really necessary unless you are going to overclock.
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GREAT BEND - Gladys L. Cripe, 86, died November 17, 2011 at Cherry Village Nursing Home, Great Bend.
LIBERTYVILLE, Ill. - Joseph Henry Kimpler, III, of Libertyville, Ill., left this earth and took the fast track to heaven on Nov. 12, in Great Bend. He was celebrating the 20th annual family pheasant hunting trip when he suffered a fatal heart attack. There he was reunited with beloved wife, Margaret, and Jesus Christ, his Savior. "Now we know that if the earthly tent we live in is destroyed, we have a building from god, an eternal house in heaven, not built by human hands" (2 Corinthians 5:1).
WILSON - Alice Elizabeth (Zeman) Homeier passed away Nov. 18, 2011.
FORT WORTH, Texas - The Lord called Engle Scott, a retired U.S. Army colonel, home on Nov. 14, 2011. Engle Wayne Scott was born in Larned, on Jan. 20, 1937, the youngest of eight children of Silvey West Scott and Dixie Shumate Scott. Until the age of 5, he lived in Ash Valley, where his father was a grain elevator and feed store manager. During World War II, his family moved to Great Bend, where he graduated from high school in 1955. He attended Kansas State University where he met and married Miss Judith Ann Higgins on Aug. 31, 1958 ...
DODGE CITY - William "Bill" Richard Setzkorn, 91, died Nov. 16, 2011 at the Hodgeman County Longterm Care Center, in Jetmore.
CHASE - Linda R. Gilmore, 68, of Chase, died Nov. 17, 2011 at Clara Barton Hospital, Hoisington.
HOISINGTON - Lyle E. Stout, 75, died Nov. 15, 2011 in Hoisington.
Doris A. Starkey, 92, died Wednesday at Ellinwood District Hospital. Survivors and arrangements will be announced by Kimple Funeral Home in Ellinwood.
RUSH CENTER - Ray L. "Pete" Keener, 75, died Nov. 15, 2011 at Great Bend Health and Rehabilitation Center.
Kathleen Kimpler, 85, died Nov. 15 at Great Bend Health and Rehabilitation Center. Born July 8, 1926 in Ellinwood, she was the daughter of George Peter and Mary Ann (Kramer) Kimpler. A resident of Great bend since 1975, coming from Ellinwood, she was a principal and teacher in the Wichita and Dodge City Diocese Catholic Schools for 34 years.
COLUMBUS - Mary Cunningham Minott, 95, died Nov. 14 at Kansas Soldiers Nursing Home in Fort Dodge. Born Dec. 15, 1915, in Carterville, Mo., she was the daughter of R.W. and Effie R. Cook Cunningham. She was a resident of Fort Dodge for several years, previously of Larned and Columbus.
LEAWOOD - Debra Ann Rumble, 56, died Nov. 8 at her home in Leawood. Born May 20, 1955, in Manhattan, she was the daughter of Robert G. and Jean E. (Antenen) Rumble. Growing up in Great Bend, she was a graduate of Great Bend High School and obtained her Master of Library Science degree from Kansas State University. A resident of Leawood, she was a retired librarian for the Turner School District. Debbie was devoted to her cats, Maddie and Murphy, who along with her family and friends will miss her.
ELLINWOOD - Lorin Peter, 84 , died Nov. 12, 2011, at Ellinwood.
GREAT BEND - John Edward Sandberg was born Nov. 28, 1956 and he left this world on Nov. 13, 2011.
LYONS - Myron J. Behnke, 69, died Nov. 13, 2011 at Via Christi St. Francis Hospital in Wichita.
Joan Charles, 84, died Jan. 5, 2015, at her home in Great Bend. She was born Dec. 2, 1930, at Oswego, the daughter of Clyde and Evelyn (Claxton) Morain. She was a butcher at Don's Food Mart, Great Bend. Ms. Charles was a long-time Great Bend resident, also residing in McKinney, Texas, and Hutchinson.
CABIN JOHN, Md. - Lora Belle Renz passed away on Wednesday, January 14, 2015, at Holy Cross Hospital in Maryland. She was born April 19, 1935, at St. Rose Hospital in Great Bend, to Arthur and Bessie (Nordman) Tammen of Albert. She grew up on a farm south of Albert and attended District II Country School.
LARNED - Troy Dean Davis, 43, passed away Jan. 16, 2015, at his home in Larned. He was born Jan. 3, 1972, in Great Bend, the son of Jerrold Dale and Sheryl Lynn Suchy Davis. A lifetime area resident, he was a service technician at Harper Camper Land in Great Bend.
HOISINGTON - Robert Frank James, 83, died Jan. 15, 2015 at Cherry Village Nursing Home, Great Bend.


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Well it's very routine in the military. Also about running.. on a second thought I'm not starting to like it, scratch that lol.
Made a bench PR some weekend which I can't remember - 7x110kg.
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Congratulations to Dr. Kim Tucker and Missy Craig, who won the SU Holiday Decorating Contest! Their Ugly Holiday Sweater theme was a big hit and got us all into the holiday spirit!...
Biology, Biotech, and Environmental Science News
Biology faculty got in the holiday spirit during the annual door/office decorating contest with an Ugly Christmas Sweater theme. Dr. Kim Tucker is pictured here in front of the tree decoration in her ugly sweater, and the door to Dr. Merrie Durmowicz's office is decorated with "Merrie" wishes. Happy Holidays to everyone!...
The annual lecture held in memory of Department Chair and Professor of Mathematics, Susan Palmer Slattery, was held last Thursday, September 18, 2014. Dr. Slattery was an inspiration to both students and faculty and will always be remembered by the Stevenson Community.
This year's lecture featured Arlene G. Weiner, an Environmental Engineer for the Baltimore District of the US Army Corps of Engineers. Ms. Weiner utilized her 30 years of experience as an environmental professional to speak on building a career in Applied Mathematics. Following the lecture, Applied Mathematics major Anna Foote was named the 2014 Slattery Scholar. She was presented the award by Ms. Thea Zimmerman, Dr. Susan Slattery's sister. Congratulations to Anna and warm wishes to the Slattery family!
Congratulations to Dr. Blatch for receiving a Faculty Development Research Grant from Stevenson. Her project will help determine why only some fruit flies are able to survive with little folic acid in their diet. She and her research students "will test the hypothesis that with little folic acid in the diet, only some fruit flies can survive to adulthood because only some individuals have the "right" kinds of microorganisms living in them, those able to provide folic acid to the flies." Consequently, flies inherently lacking microbes that can provide the vitamin die, which causes the higher death rates seen in flies not consuming folic acid. They will also determine at which developmental stage(s) the flies grow faster and when they are more likely to die when they rely on folates from their microbes. Good luck this semester!
Congratulations to Dr. Tucker for receiving the Faculty Development Scholarship Grant from Stevenson. Her project is titled "Incorporating Electronic Laboratory Notebooks (ELNs) into an Introductory Ecology Course" and its purpose is to introduce students to ELNs and collect data to assess the effectiveness of incorporating technology into an introductory field-based ecology laboratory course (BIO115L). Dr. Tucker proposes to enhance the course by incorporating a collaborative ELN that is stored online via the cloud and accessible through a variety of interfaces (PC, tablet, smartphone). Specifically, student groups will use a tablet to record experimental methodology and observations in the field. At the end of each project, each student will analyze and document the group's data independently, as previously determined to meet the course objectives. Using the ELN will help students to more efficiently collect and share data among their groups. Incorporating ELNs in introductory courses will help to get students prepared to use ELNs in practice for their research and in upper-division undergraduate courses. Good luck this semester!
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Diwali is one of the biggest festivals in India and people from all walks of life try to enjoy it as they can. In the film industry, festivals are always celebrated with much enthusiasm. It is an opportunity to bond with friends and colleagues from the industry and also gives rise to newer equati
Shilpa's luxury anniversary gift
Shilpa Shetty spent her first wedding anniversary yesterday in Dubai with husband Raj Kundra at her new home on the ninetieth floor of the world's tallest building, the Burj Khalifa. Says a source close to the actress, "Shilpa was thrilled when Raj gifted her the luxury apartment. It's his wedding anniversary gift to her. He gifted her the keys in Mumbai a week ago. She had visited Dubai a few months ago, had loved the building and expressed a wish of staying there. The couple has taken a three-day break to celebrate their first wedding anniversary there. Raj also has something else planned for Shilpa - a lavish dinner with a few surprises thrown in." Shetty will design the interior of the apartment while she's there. She then heads to Bangkok to shoot a shampoo ad on November 26.
Raj Kundra
Only three days to go for the festival of lights and Bollywood is geared up for the Diwali and celebration kick-starts. In the weekend, Shipa Shetty and her businessman husband Raj Kundra threw a grand pre-Diwali party and close friends from the industry attended the party. Shilpa's paren
Shilpa Shetty and her husband Raj Kundra met with an accident. Fortunately, they escape unhurt. While coming back from Jalandhar, Shilpa and Raj narrowly escape the mishap. The couple went to Jalandhat to address some promotional event. The accident took place when the other car tried to


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1969 Amphicar 770 Convertible '69 Amphicar 770 Convertible, red with tuxedo interior, very collectable, minor imperfections in the paint but still very presentable, very cool... More
1960 Bentley S2 Left Hand Drive '60 Bentley S2 Left Hand Drive, 2 tone dark blue with light blue, navy blue interior, A/C, upgraded to... More
Original car with matching # and 4.7 engine. Currently in Spain with Euro taxes paid but still has its US title. Needs paint, chroming, interior... More
1958 MG A roadster VIN HDR43 / 58142 Engine 16GA / U /276 Very good restoration project, stored inside since 1966 Body is very good except for... More
1962 Ford Thunderbird, hardtop, 2 Door with 390 Engine and slide-away steering wheel. This bird is in fair to good condition. The car was... More
1950 Ford woody wagon,a true "barn find",last on the road in 1975,and just retrieved today,11/11/14.This Ford seems to be 100% complete and original,accessorized with... More
This vehicle is equipped with a Cummins Diesel Engine as well as an Allison Transmission. In addition, the front cab is capable of safely seating 3... More
1958 MG A Roadster '58 MG A Roadster, red with black interior, comes with a soft top frame and tonneau cover, solid wheels, excellent original... More
Stk. 1915 1962 Volkswagen Beetle Rag Top This 1962 VW Ragtop is a three-owner, 69,210 mile North Carolina true survivor. The car was originally purchased... More
1959 Chevrolet Apache 31. Six cylinder, three on the tree. Electric Buckets. Box is off a 1990 Silverado.Truck came out of Florida. Paint and... More
1970 Chevrolet Corvette, # 's matching 454/390 BIG BLOCK! Great driver / candidate for restoration. $5,000 in work has just been done, new brake... More
1956 Ford Thunderbird convertible, yellow with new brown interior, convertible top, frame, rebuilt 312 engine, auto trans, new wiring, front suspension, brakes and tires,... More
1954 Morris Minor Coupe This is an all original Right hand drive version. Runs and drives. Solid body needing paint. Minor rust in the floor... More
1986 Porsche 911 Carrera Cabriolet '86 Porsche 911 Carrera Cabriolet, matching numbers, chassis#WP0EB091XGS171770, engine#64G06899, silver with navy blue interior, blue soft top, power windows, A/C,... More


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A Different Kind of Star Trek RP
View Single Post
Join Date: Jan 2013
Posts: 14
# 22
I checked out the site, both the main one and a few of the Duty Stations sites. Looks interesting.
I might try creating a character, and I'd definitely try for Starbase Horizon if I did. I won't bring in any of my STO Characters, though--while they will exist, they're busy having adventures in the Alpha and Beta Quadrants.
Instead, if I do join, I'd create a brand new character--most likely a Fighter Pilot testing out a new, experimental fighter design--the Messiah-Class Starfighter (heavily inspired by the VF-25 Messiah from Macross Frontier).
I'm still thinking about it, though--and I'll post here first if I do decide to join.
Well if you do I hope to walk with your character through the corridors of Horizon. Great group of people and we just ended our current plotline. Also, keep in mind that Star Trek Borderlands and STO have nothing in common what so ever. Both are different games with different playing styles.
It's nice to see you guys coming up with stuff too. Just keep in mind that not everything gets the green light and it all comes down to the chain of command. They have the real say on what is created and what not. At least to my understanding.


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If you're looking for 810, you might want to keep an eye out for his Baltimore compatriot Black Sunn; the two innovative emcees travel in a pack these days. So although we hadn't heard from 810 since his Glass Half Full mixtape dropped months ago, as soon as I saw Sunn's Black Serenade pop up last week I knew some 810 freshness couldn't be far behind, and sure enough, today I've been bumping Save Me Now, a smoothly produced joint by kid wonder Mydus that 810 uses to flew his storytelling muscles, lyrically touching on the stories of a young woman desperate for love and a soldier in Iraq. To be blunt, I dare you to hate on this. That's right, I dare you. What? Save Me Now is off the same Ashley Outrageous Playlist mixtape that brought us BOOGNIGHTS and K. Sparks' Show Business; and for more from 810 keep an eye out for his, you guessed it, collabo mixtape with Black Sunn, dropping this spring and hosted by DJBooth.net.
Written by Nathan S. on 02/21/10
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First DJ Booth Appearance:
"Pay Day" (2009)
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There is 1 private schools in zipcode 04474, ME, serving 92 students.
Minority enrollment is 8% of the student body, which is less than the ME state average of 10%.
The student:teacher ratio of 9:1 is equal to the state private school average of 9:1.
04474, Maine Private Schools
- School Location Students Grades
OrringtonCalvary Chapel Christian School
154 River Rd
Orrington, ME, 04474
(207)991-9684(Christian)92 students | Gr. PK-12
Zipcode Statistics
About This Zipcode (04474) | Zipcode Statistics | (ME) State Statistics |
Population (Approximate) | 3,733 people | 1,319,840 people |
Age 25+ w/College Degree | 29% | 26% |
Median Household Income | $62,207 | $44,663 |
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Updated January 22, 2015
When making an important decision that will impact the lives of your children, you need to have all the facts in place. We compiled a list of the most important factors to consider when choosing a final private school for your child.
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Here are some more answers and resources to help you deal with tough questions such as "What do I do when my child doesn't test well?"


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An Actual Good Reason To Cancel GEICO Insurance
Submitted by Chris Madcowski on Tue, 01/29/2013 - 00:18They think it's funny to use bestiality jokes to sell their service:
Ha Ha! That girl is on a date with a pig! And now she wants to have intimate relations with him! Sexual activity with animals is funny and extremely appropriate! Mommy, what's going on? That pretty girl wants to kiss a pig!
BTW the 'GEICO cancels gun employee's policy' story is turning out to be a hoax or at the very least a big misunderstanding fanned by the recent gun control hysteria. It's not a private vehicle, it's a commercial vehicle, and the policy would never have been issued in the way it was if this had been disclosed initially.
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at least this makes more sense than the "Jewish Witchcraft" thread.
oy vey...
A signature used to be here!
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You mean, other than the fact that...
it is owned by Warren Buffet and pads his pockets.
its 'cos I owe ya, my young friend...
Rockin' the FREE world in Tennessee since 1957!
9/11 Truth.
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the pig and the doughboy should get together...
Tweeting occasionally as himself @cudnoski on the twitter.
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Jake Silbermann Guest Stars on Gossip Girl
Just how versatile is As the World Turns star Jake Silbermann? He can play a gay man in love with Noah one second… and a womanize...
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text: Evidentia 2.2.1 has just been released. This is a simple bug fixing release, and includes the following: Removed save button on create template Fixed error in mini-editor after pasting content Fixed object is not a function error after saving citation generated from new template Fixed misc Dropbox issues Fixed issue with digital file manager All current users are encouraged to upgrade to the latest release. You can find the links at http://evidentiasoftware.com/evidentia-upgrade/ … Continue reading


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Health Professionals: 1 to 20
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Medicaid Health Professionals in Palatka
Area auto widened to Putnam County -
only 2 Health Professionals were found in the city of Palatka, .
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Michelle Vitner
Massage Therapist, LMT, LPN
"Using Swedish massage, Shiatsu, Reiki and other modalities, I bring careful attention to knots and trigger points in fascia, muscle and soft tissue, as well as the energy field, so you can let go of old patterns in the body. I love working with all members of the family, from birth through old age, to bring about the balance of mind, body & spirit. I believe that massage is a beautiful way to increase health, prevent illness and feel more joy in our lives.I focus on integrating the physical, mental, emotional and spiritual dimensions for a healthy life.
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John F Rhodes
Dentist, DMD
"Our office encourages each patient to take control of his or her own health. We can help patients achieve optimum dental health and improve their quality of life. We desire relationships to patients that are always win-win, mutually beneficial. Our staff is kind, professional, and concerned, and we recognize that your dental healthcare options are many, so we do our level best to give maximum customer service. Our aim is to assess and to resolve any oral concerns you may have, as gently as possible.
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Lana Hathaway
Massage Therapist, LMT
"I have over 30 years of experience from specialized medical massage to relaxation message. I have helped people with several problems & injuries by listening to what they are experiencing and then tailoring my therapy to their needs. Whether you have a prescription from your MD or physical therapist for massage or you are just looking for someone to help with those nagging aches and pains, I will give you an honest and thorough assess and provide you viable treatment options. I have special equipment to make pregnant clients extra comfortable.
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Sue Degrazia
Massage Therapist, LMT
"I am an accomplished alternative healthcare professional, with over 17 years of hands on experience in the bodywork field. I am passionate about massage therapy because of what it has done for me personally, and the positive results that I have witnessed for so many of my clients. It is important to me as your massage therapist, to provide a treatment plan that is unique to you, and supports your health goals. I have experience treating a variety of medical conditions and have worked with adults as well as children. I also take no-fault insurance.
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Mark Schiffman
Massage Therapist, LMT
"With a degree from the Swedish Institute, I specialize in a number of techniques. Swedish massage employs firm but gentle pressure to improve circulation, ease muscle aches and tension, improve flexibility and create relaxation. Five-Element Shiatsu provides an Eastern perspective which emphasizes the flow of Qi, or energy, through the body. Shiatsu is an traditional, Japanese healing method and it means "finger pressure." Shiatsu utilizes acupressure points and stretching. It's a form of "touch manipulation," and is a safe and effective curing or preventative medicine that helps to balance a person's energy flow and strengthen vital organs.
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Jo Anne Tenzer
Acupuncturist, MS, LAc
"I am a New York and Connecticut State Licensed and Nationally Board Certified Acupuncturist. I maintain my practice in Mahopac and Yorktown Heights New York, and a newly established Stamford Ct. office location. I provide general, preventative and lifestyle acupuncture for all ages (from 3 weeks to 94 years of age).
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Carin Piacente
Massage Therapist, DC, MS, LMT, CDT-MLD
"My primary focus as a licensed massage therapist is to provide the utmost care and treatment plan to each and every client. I focus primarily on medically based massage. I am trained in pregnancy massage, Hot Stone Massage, and Complete Decongestive Therapy and Manual Lymphatic Drainage. I am currently pursuing a Doctorate in Chiropractic and a Masters in Nutrition.
I am A.R.T. certified in spine and lower extremities
Thomas Swisshelm
Naturopath, MEd, EdS
"I use EEG Neurofeedback and the Interactive Metronome to help the brain become better functioning. These methods work well with those challenged with ADD, Autistic Spectrum Disorder, Anxiety Disorder, Sleep Disorders, and Migraines. Neurofeedback is a non-intrusive therapy and can be used with children and adults without side effects. One of the goals of Neurofeedback is to decrease or eliminate the need for medications.
Keys Chiropractic Clinic
"I have been in practice 30 years and use full spine hands only adjusting. I utilize the Gonstead technique. I am also a certified acupuncturist. I was the team physician for the boys soccer team at Winfield high school for 7 years and enjoy working with athletes of all sports.
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Stephen Schachter
Acupuncturist, LAc, AP
"I began learning in 1976 with Macrobiotics, eventually studying Chinese Medicine via apprenticeship with a 5th generation Korean master and was licensed in 1982. I've been in private practice since then. My treatment style is a mixture of many approaches, with a main emphasis on "Taoist style." I am also certified in Acutonics Sound Healing. I specialize in treating pain, injuries and internal diseases. My treatments are known for their rapid effects and gentle touch. I am well versed in treating physical, emotional and psychological disorders, both acute and chronic. You will be deeply listened to and cared for.
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Susan B Hintze
Massage Therapist, LMT
"I graduated from the Connecticut Center for Massage Therapy in 2006. I have experience working at a Day Spa, a high-end Gym, in a corporate setting, and currently at a Chiropractic office. Each client presents as a unique case. I treat female and male clients from teens to seniors.
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Kathy Levine
Nutritionist/Dietitian, MS, RD, CDN
"I am a Registered Dietitian Nutritionist who is passionate about helping others attain optimum health and achieve a happier, healthier life. With a BS from Cornell and a MS from Columbia University, and an extensive background in nutrition and exercise science, I have developed specialties in weight management, diabetes, digestive issues, kidney disease and high cholesterol. With compassion, patience and an understanding of the frustrations and difficulties of dieting, I can teach you the tools and the strategies you need to reach your goal weight, while increasing your energy and longevity at the same time!
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Natalie Kasdan
Massage Therapist
"If you have been experiencing either acute or chronic pain and are looking for relief, then craniosacral therapy can help you. Craniosacral Therapy and Somato Emotional Release can help heal emotional trauma and provide relief from anxiety, stress, depression, and many other ailments. Receiving treatments during pregnancy can alleviate any discomfort or pain and create a more balanced environment for your baby. Whether you are newborn or 100 these healing arts can help you find physical and emotional relief. Helps with ADHD, autism, colic, ear infections in children. Also helps newborns and mommy with releasing birth trauma.
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Terry Jeanne
Acupuncturist, MSOM, L, Ac, Dipl, OM
"SORRY, TERRY IS NOT ACCEPTING ANY NEW PATIENTS AT THIS TIME. Different people respond differently to the many types of acupoint stimulation in Oriental Medicine. Terry's style is to find the best method for the best resolution. This makes her perfect for difficult to treat cases such as pain syndromes with nerve involvement or people who are easily made worse with various therapies or diets or even favorite activities. Anyone wishing to be proactive and work at a new level of self-understanding for better health will love this approach. Skeptics who want change are the best!
L. Terry Chappell
Medical Doctor, MD
"I practice INTEGRATIVE MEDICINE which combines the best of conventional and alternative medicine. I am well-known throughout the U.S. and internationally for my publications and teaching in this field. In my practice I deal extensively with chelation therapy, prolotherapy and environmental medicine. I also treat fibromyalgia, yeast/digestion problems, ADD/ADHD and I am a Defeat Autism Now "DAN" doctor that treats for autism
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Lagasse Nutrition Therapy
"Master's level Registered Dietitian/ Nutritionist with 13+ years experience in the field of Nutrition. I am a certified Intuitive Eating Professional with many years experience with disordered eating concerns and all eating disorders. I also have experience with general nutrition therapy, chronic disease/ conditions- such as diabetes, heart disease, & digestive diseases. All ages welcome.
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Patricia Ann Heraghty
Acupuncturist, LAc, Dipl, Ac, OT
"After working the past 20 years as an Occupational Therapist in a variety of healthcare settings, I became interested in approaching healing from a different perspective to help people become empowered about their health on all levels. I found acupuncture to resonate with my belief that medicine should be judged in terms of how effective it is in understanding and treating the problem as the patient experiences it. Safely, painlessly, acupuncture is able to address a wide variety of medical conditions. Both Western and Traditional Chinese Medicine have their respective strengths, and when appropriately combined, the patient is well served.
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Michael Gazsi
Naturopath, ND
"My training as a specialist allows me to treat my patients using clinical nutrition, herbal plant extracts, auricular accupressure, manipulation, exercise therapy, homeopathic dilutions, and counseling. I specialize in chronic fatigue and my focus is in using unique alternative testing, alternative therapies, and natural medicines to find relief for my patients, as well as, diagnosing and treating acute, chronic and irresolvable health issues. My methodology produces successful results in patients unable to find relief through standard medical treatments.
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CT Center for CranioSacral Therapy
Massage Therapist
"I have been practicing massage therapy and craniosacral therapy for more than 10 years. I am very passionate about how the body works and the connection between the physical and emotional aspects of ourselves. With advanced training in craniosacral therapy, and years of practical experience, I act as facilitator to your body's innate ability to heal itself by offering a gentle approach, specific CST techniques, an open mind and a safe, healing space. I have dedicated my heart and hands to CST and am committed to furthering my training and practice for years to come. "Body, Heal Thyself".
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Rennie J Statler
Chiropractor, DC
Medicaid Health Professionals If you have health insurance coverage with Medicaid, or you're looking for Medicaid Health Professionals in Palatka (or Palatka Health Professionals who accept Medicaid), please contact these Health Professionals and confirm that they are either in-network with Medicaid are or can help you with your Medicaid coverage.
How to tell if Natural Health is right for me? Palatka Health Professionals have broad skills and are able to work with a wide range of symptoms. Complementary and alternative health, natural health or holistic health is a non-medical path to well-being. It sees the physical, mental and spiritual aspects of life as closely interconnected and balanced. Advocates typically use a wide variety of alternative practices, the most common of which include: Acupuncture, Chiropractic, Homeopathy, Massage Therapy, Naturopathy, Nutrition, Osteopathy, and Physical Therapy. |


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What Would Jesus Really Do? The Power and Limits of Jesus Moral Teachings
The author is a professor of ethics at California State University at Fresno. This book examines what Jesus said or didn't say about abortion, euthanasia, the death penalty, war and peace, homosexuality and the family.
Aug 04, 2008


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The generational gap in oil & gas industry is getting bigger and bigger and the challenge here is to attract the Generation Y workers. Keeping the same old business model will not be sustainable in the workplace much longer.
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HR of both mergering companies can and have to play a pivotal role to guide all employees through the difficult process that starts with the announcement and ends with...
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Lazy Susan for Oils & Vinegars
By A Southern Soul on February 05, 2013
Over the past few months, I've received so many great questions about cooking and food. One of the most frequent..."what's your favorite thing in your kitchen?" Well, that's really hard to answer because I have several. So, I decided to share a few, starting with one of my TOP 3! I use a Lazy Susan to help me out with all of my oils and vinegars. It sits right beside a work space in my kitchen and keeps everything in easy reach. I wish I could take full credit for this great idea but unfortunately I can't. Last fall, my friend, Hope and I enjoyed a beautiful Sunday afternoon at the Greensboro Symphony Guild Tour of Homes. One of the stops on our tour had the most awesome kitchen - that's where I "borrowed" this idea! I grabbed my note pad and jotted down a reminder and I am so, so, happy I did! I already had this great marble Lazy Susan, so I cleaned it off, gathered my oils and vinegars and selected the perfect spot in my kitchen. Every bottle is in reach, I can clearly see what's on hand, it looks great and inspires me to be creative.
This is one of A Southern Soul's all time favorites!
Olive Oil~ Extra Virgin & Lemon Infused from Midtown Olive Press, Canola Oil, Balsamic Vinegar, Pomegranate Vinegar from Midtown Olive Press, Rice Wine Vinegar, Red Wine Vinegar.
What's YOUR favorite in the kitchen?
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The Wall
Categories: Pub & Nightlife > Massage parlours
Address: 36 Soi 1, Khampang Din Rd., Muang Chiang Mai, Chiang Mai 50000 Thailand See map
0 reply, 3,203 viewed
The Wall is a gay spa in Muang Chiang Mai district. It offers a variety of massages such as oil massage, cream massage, Thai massage, four hands massage and body scrub. Guest should try the coffee scrub that uses an exclusive and unique recipe. They also provide an outbound service.
- Open days
Monday, Tuesday, Wednesday, Thursday, Friday, Saturday, Sunday
Input price range
450 - 800 Baht/Day or 15 - 27 USD/Day
- Address
36 Soi 1, Khampang Din Rd., Muang Chiang Mai, Chiang Mai 50000 Thailand
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+66 (0) 5327 4275
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+66 (0) 80617 5000
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The Victoria and Albert Museum's "Vivienne Westwood" gathers more than 150 creations by the British designer who in the 1970's dressed the Sex Pistols in tartan bondage trousers. Her career may have begun with rubber T-shirts, but it soon progressed to elaborate ball gowns, suits, and ready-to-wear, all of which theatrically reinterpreted historical styles (the corset, the bustle, the hoopskirt). "The only reason I'm in fashion," Westwood told The Face in 1981, "is to destroy the word conformity." Could there be a better reason?April 1-July 11.
—Jaime Gross


text:
Harrison Township
March 07, 2014L'Anse Creuse's Richter reflects on run to state title match
By Jason Carmel Davis
C & G Staff Writer
Harrison Township L'Anse Creuse senior 171-pound wrestler Devan Richter placed second in his weight class at the 2014 MHSAA D1 state finals. Richter, left, is pictured during the 171-pound state title match, which took place March 1 at The Palace of Auburn Hills.
AUBURN HILLS — Harrison Township L'Anse Creuse senior 171-pound wrestler Devan Richter said he had a great experience competing at the 2014 Michigan High School Athletic Association Division 1 state finals.
Richter finished second in his weight class to Novi Detroit Catholic Central's Drew Garcia, who was able to hold on for a 5-2 win over Richter in the D-1 171-pound state title match, which took place March 1 at The Palace of Auburn Hills.
"It's been a great experience. It's my last year. I would have liked to come out of it with the title; that's the only thing I would have changed," said Richter, who ends the season with a 56-2 record. "I had a great time. I was here with my family and teammates. I couldn't have asked for a better time."
Lancers wrestling coach David Prince said it was a tough loss for Richter. His only two defeats this season came to Garcia.
"We watched a lot of video on what (Richter) needed to fix," Prince said. "He brought the aggression this time; however, he allowed Garcia to control the tie, which we didn't want him to do.
"Devan worked really hard to get to this point. I'm sad to see it end this way."
Richter said his wrestling career doesn't end with the loss in the state finals. He said he plans to enroll at a community college in Iowa and hopes to end up wrestling at a Division 1 university.
"This year's been awesome. I think I wrestled awesome, outside of a couple of matches," said Richter, who placed fifth at the state finals in 2013 to also earn All-State honors. "I had a great time with my teammates. I love my teammates. I wouldn't trade them for anything."
The top eight wrestlers in each weight class earned All-State honors.
"This was a great year for Devan," Prince said. "His only two losses are to Garcia. I wish I had another year with him."