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Category Archives: Yoga
43 post(s) found
Stop Waiting
I've preached quite a bit over the past year about all the ways yoga — specifically Bethany and Lyons Den Power Yoga — has impacted my life and powerfully changed the way I choose to live it. I really do […]
My 2014 Game Changers
For the past two years, I wasn't really into the "year end recap" thing. I cringed looking back on the two previous years, and wanted pretty desperately to just move forward. As I said time and time again, 2012 and […]
Posted in Celebrity Sightings, Crohn's disease, Family, Happy Things, NYC, NYC Marathon, Races, Running, Yoga and tagged 2014, Bethany Lyons, Bridgehampton Half Marathon, Bronx 10-Mile, Crohn's Disease, Dance Spirit, Family, Hawaii, JackRabbit, Katie Couric, Lyons Den Power Yoga, New York City Marathon, November Project, Races, Ragnar Relay, Ragnar Relay Adirondacks, Runner's World Half and Festival, Running, Solstice in Times Square, Spring Duathlon at Smolak Farms, Yoga-
Back On The Run
Blog? What blog? Eeeeesh, I suck. I know. To think I used to write daily here… But the absence is with good reason, you see. Last summer, I abandoned this blog for weeks at a time because I was too […]
Posted in Central Park, Crohn's disease, Family, Happy Things, NYC, Running, Work, Yoga and tagged Crohn's Disease, Marathon Training, November Project, Running, Steamtown Marathon-
I've been wanting to write for a while. A big reason I haven't been posting — so much for that "groove" I thought I'd hit — is that I simply don't have time. A bigger reason for the absence is […]
Posted in Biking, Crohn's disease, Running, Yoga and tagged Biking, clinical trial, Crohn's Disease, Cycling, Lyons Den Power Yoga, Methotrexate, Running, Steamtown Marathon, Study Drug, Yoga-
So here's something I have been wanting to write for a very long time: I am happy. Not just "I had a good day today!" happy, but more like, "I've had a lot of really good days in a row, […]
Posted in Central Park, Crohn's disease, Happy Things, NYC, Running, Stress, Yoga and tagged Aladdin, Crohn's Disease, Dance Spirit, JackRabbit Sports, Luke's Lobster, Lyons Den Power Yoga, Running, SoulCycle, Spinning, Work, Yoga-
On My Mind
First, a note about Boston: It seems wrong to write without acknowledging the one-year anniversary of the Boston Marathon Bombings. I hate that that's how we reference the anniversary. I don't like that "Boston Marathon" is attached to the word […]
Posted in Crohn's disease, Movies, Yoga and tagged Ann M. Martin, Baby-sitters Club, Boston Marathon, Instagram, Lurlene McDaniel, My Sister's Keeper, The Fault in our Stars, Yoga-
Last Friday morning, I was taking my usual obnoxious expensive cab to work, and the driver asked me the most annoying question a cab driver can ask, which is, "Which way do you want to go?" (I always think they're […]
Posted in Celebrity Sightings, Central Park, Crohn's disease, Happy Things, NYC, Running, Yoga and tagged Central Park, clinical trial, Crohn's Disease, Henry Winkler, Lyons Den Power Yoga, New York City Marathon, Running, Spinning, Yoga-
February 18
I was going to stop by the internet today to tell you about the very disappointing failure that was February 10. About how I showed up for my appointment, so excited in my tracksuit, and Study Lady was just shocked […]
It's Christmas Time In Contoocook
It's been a while! The excuse-truth for being anti-blogging: I'm Crohnsing pretty hard. I know I know I know I know. It's the never-ending shitstorm, and that's not even supposed to be a pun. Though the puns are practically unavoidable […]
Posted in Biking, Crohn's disease, Family, Holidays, NYC, NYC Marathon, Running, Travel, Winter Things Like Snow, Yoga and tagged Biking, Christmas, CitiBike, Contoocook, Crohn's Disease, Holidays, Lyons Den Power Yoga, New Hampshire, New Year's Resolutions, New York City, New York City Ballet, New York City Marathon, Radio City Christmas Spectacular, Running, The Nutcracker, Travel, Yoga-
Thankful Things Thursday: For Basically Everything Ever
People say the worst feeling in the world is heartbreak. I say the worst feeling in the world is when you come in from a frigid run and jump into a scalding-hot shower too fast, and then your legs turn […]
Posted in Central Park, Crohn's disease, NYC, Running, Thankful Things Thursday, Weddings, Yoga and tagged Central Park, Cooking, Crohn's Disease, Running, Thankful Things Thursday, Weddings, Yoga-


text: Heaven Sent Angel Wing Necklace by Suzy Q £36$68.68€47.40$60.27 17 customer reviews(17) In stock £2.75$5.24€3.62$4.60 mainland UK delivery - Order now and receive this item on or before Friday 30 January £2.75$5.24€3.62$4.60 mainland UK deliveryEstimated delivery: up to 3 days £9.70$18.50€12.77$16.24 Express Next Day 1pm - Order now and receive this item on or before Wednesday 28 January Express delivery available International delivery available chain lengthchain length (required)16 inch18 inchWithout chain (just charms) (- £12)chain length (required)16 inch18 inchWithout chain (just charms) (- $22.89)chain length (required)16 inch18 inchWithout chain (just charms) (- €15.80)chain length (required)16 inch18 inchWithout chain (just charms) (- $20.09) angel wing coloursangel wing colours (required)One Silver, One BronzeTwo Silver (+ £4)Two Bronze (- £4)angel wing colours (required)One Silver, One BronzeTwo Silver (+ $7.63)Two Bronze (- $7.63)angel wing colours (required)One Silver, One BronzeTwo Silver (+ €5.26)Two Bronze (- €5.26)angel wing colours (required)One Silver, One BronzeTwo Silver (+ $6.69)Two Bronze (- $6.69) quantity by Suzy Q Location: East Sussex, GB read seller's profile see seller's complete range more items from this seller Pine Cone Necklace £26$49.60€34.23$43.53 Silver Zodiac Constellation Necklace £34$64.86€44.76$56.92 Personalised Chunky Leather Identity Bracelet £39$74.40€51.35$65.29 Personalised Paracord Survival Bracelet £39$74.40€51.35$65.29 Two Peas In A Pod Necklace £25$47.69€32.91$41.85 Personalised Words Cufflinks £38$72.50€50.03$63.62 view all you may also like PRODUCT DETAILS CUSTOMER REVIEWS DELIVERY RETURNS ask seller a question A beautiful necklace with two stunning angel wing charms. 'I want to be the one who you believe in your heart is sent from heaven' - Keyshia Cole What a gorgeous way to say 'I love you', 'I'm thinking of you' or 'I want to be with you always'. So sweet and delicatly detailed, one silver angel wing charm and one bronze angel wing charm hanging from a silver curb chain. Available with 16 inch or 18 inch sterling silver chain. made from: Silver charm - solid sterling silver Bronze charm - bronze dimensions: Charms - length 2cm x width 0.5 cm product code: 198518 17 customer reviews Tue 25 Nov 2014 Excellent product and Suzy Q was efficient and prompt in delivery; and very helpful when I wanted to change my item and needed the new item quickly for a specific date. Mon 29 Sep 2014 Bought as a present and it's lovely. Wed 10 Sep 2014 Lovely necklace. Much daintier than it appeared in the image. Very pleased with my purchase Sat 08 Mar 2014 Lots of people commented on how pretty my necklace is, excellent value for money. Thu 06 Mar 2014 I LOVE IT! 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subset: commoncrawl


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Published: Sat, May 9, 2009
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Police: Wesleyan Suspect Wrote 'Kill Johanna'
The man who's charged with gunning down a Wesleyan University student made his first court appearance. Stephen Morgan was arraigned Friday in Middletown Superior Court. Officials found the 29-year-old the night before standing outside of
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Live 'Private Cloud' Spotted in New Jersey Rock Quarry
- Friday October 21, 2011
"We created a hybrid," says NYSE Technologies CEO Stanley Young. "It's a cross between the public cloud and the private cloud." To the average English speaker, this sounds like gibberish. But in the computing world, it makes perfect sense. No, really, it does.


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Document Type: | Book |
All Authors / Contributors: |
Christine Wertheim; Dodie Bellamy; Les Figues Press, |
OCLC Number: | 170922335 |
Notes: | Author uses pipe symbol to represent selected instances of the letter "i". "'For Love Alone' Christina'S-tead, bk. 1, vol. 2 ... doc. 001b, society for cUmIn' linguistics (scUm)"--T.p. "+I'me'S-pace (doc. 001.b_ is an introduction to a wider poetic examination of English, enttiled 'For Love Alone' Christina 'S-tead"--Afterword, p. 109. |
Description: | 109 p. : ill. ; 24 x 11 cm. |
Series Title: | TrenchArt, the casements series, 4 of 5.; TrenchArt, 2/3. |
Other Titles: | For love alone Timespace |
Responsibility: | compiled by Christine Wertheim ; with an introduction by Dodie Bellamy. |
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Monday 26 Jan 2015
By Martin Bailey. News, Issue 227, September 2011Published online: 07 September 2011
Durham Cathedral was not given an opportunity to buy the St Cuthbert Gospel, which is regarded by Durham Cathedral as a sacred relic. The Jesuits, who have owned the manuscript for nearly 250 years, are instead selling it to the British Library (BL) for £9m. Dating from the 7th century, it was discovered in the saint's coffin in the cathedral and is the world's oldest surviving book in its original binding.
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Cathedral dean Michael Sadgrove told The Art Newspaper: "We did not know that the St Cuthbert Gospel was on the market until the British Library approached us in confidence about six months or so ago, but by that time the process was well underway. It was all kept very quiet. I am sorry that we were not consulted." Nevertheless, Sadgrove is pleased that a tripartite agreement has been reached between the library, Durham University and the cathedral. The British Library has promised that the Gospel will be displayed in the north-east of England for alternating 18-month periods with London.On 14 July the library announced that it had been offered the chance to buy the St Cuthbert Gospel from the British Province of the Society of Jesus. The National Heritage Memorial Fund has pledged £4.5m. A further £1.75m has been raised, including £250,000 from the Art Fund and £250,000 from the Garfield Weston Foundation. This leaves a remainder of £2.75m to be found before the 31 March 2012 deadline.Jesuit Father Kevin Fox points out that the St Cuthbert Gospel has been on loan to the library since 1979, so this "made it natural to offer it to them first". This was done by Christie's, the Jesuits' agent, in late 2009. Agreeing a valuation took nearly a year, and last December the BL informed Durham Cathedral about the sale and offered a loan arrangement. The Jesuits and Christie's made no direct contact with Durham Cathedral.The Gospel became separated from the other St Cuthbert relics during the Reformation, and the remainder are still at Durham Cathedral, including a pectoral cross and portable altar. Sadgrove said that the gospel was "used in funeral rites and visiting dignitaries were honoured by having it hung around their neck in procession".By coincidence, the cathedral has plans to move its own St Cuthbert relics from the present display in the former monastic dormitory to a new treasury in the 14th-century vaulted great kitchen. Permissions for the necessary alterations are now being sought and a £6m fundraising campaign for the work is to be launched this autumn.The new treasury, with up-to-date climate control, is scheduled for completion in summer 2013, when the BL has agreed to send the Lindisfarne Gospels to Durham University on a three-month loan. Dating from 715, the Lindisfarne Gospels were transcribed to celebrate the life of St Cuthbert. The cathedral hopes that it may also be possible to borrow the St Cuthbert Gospel which would be the first time that it has returned to Durham since the Reformation. If the new treasury is not ready, then both manuscripts are likely to be exhibited in Durham University's Palace Green Library, which lies very close to the cathedral. Lindisfarne to London in 1,300 yearsCuthbert died as a hermit on the remote island of Inner Farne in 687 and was buried at the monastery on the island of Lindisfarne, just off the Northumbrian coast. In 698, on elevation to the sainthood, his body was reinterred in a new coffin—and he was buried with the Gospel of St John. British Library curator Scot McKendrick believes that the Gospel was probably transcribed for this occasion, although it is possible that it was the volume which had been used by the saint during his lifetime. The Latin text was transcribed in the monastery of Wearmouth-Jarrow. Bound in red leather, it is small enough to fit into the palm of the hand. With the threat of Viking raids, St Cuthbert's coffin was evacuated from Lindisfarne in the ninth century and taken first to Chester-le-Street and later to Durham in 995. In 1104 the coffin was opened before being placed in a shrine behind the cathedral's altar, and it was then that the relics were removed.
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10 Sep 11 21:32 CET
Selling to the British Library, a secular institution, avoids the multiple ironies of a religious body, which acquired the manuscript as a gift only as recently as 1769, selling a Gospel Book and relic back to the shrine originally constructed by the Monks of Lindisfarne as a secure place to hold it and other of Cuthbert's relics. I suspect also Chrisite's may have been unaware of the Dean and Chapter of Durham's relative prosperity: unlike many other English cathedral chapters which have been in poor financial condition for much of the period post WWI, Durham did not commute the entirety of its lands, and other sources of income, for either a capital sum or fixed income under the various Ecclesiastical Commissioners Acts of 1836-66.
9 Sep 11 16:37 CET
The Jesuits have operating expenses the same as all organizations. Its my understanding that charitable contributions are way down. Alas, it has also become far more difficult to plunder from other civilizations, thus the need to cannibalize your own treasure to survive.
9 Sep 11 15:5 CET
Pity the Jesuits sold it -- seems cheap and I bet at auction it would have sold for twice that. Here in SF the Jesuits sold many treasures from the USF library to a storm of disapproval. All sold too cheaply and are irreplaceable. What is it they don't get about a mess of pottage?
7 Sep 11 22:25 CET
It's shocking that Durham Cathedral was not approached for the purchase. But at least it will be displayed in the NE of England "for alternating 18-month periods with London." Presumably, 'The Reformation' is the factor here.
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It's shocking that Durham Cathedral was not approached for the purchase. But at least it will be displayed in the NE of England "for alternating...
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Page 1 of 60
The Nintendo difference: Wii U's first two years
I feel a bit bad saying this, as I love Nintendo dearly, but Tom Bramwell picking out the Gamecube as one of his favourite consoles ever, got me thinking.
He's absolutely right - the Gamecube was Nintendo at its creative best. It launched some fantastic new franchises in Animal Crossing (at least in the West, where we never got the N64 version), Luigi's Mansion and Pikmin, it completely rejuvenated the Metroid franchise into something that was even better than the brilliant original, Zelda's art style was magnificently transformed in Wind Waker, and the core fan service was there in games like F-Zero GX, Smash Bros, MK Double Dash!! I even think Mario Sunshine deserves more credit than it gets.
And that's just Nintendo's output - add in the Capcom Five, Super Monkey Ball, Rogue Leader and even ports like Skies of Arcadia: Legends or remakes like MGS: Twin Snakes and Resident Evil, and it really was a console that had it all. And most of it was exclusive too.
Yet the console is largely considered a flop.
The Wii U doesn't even come close, and the big problem for me, is that I don't see Nintendo even trying to do the same thing.
If, like me, you've owned a GBA, Gamecube, Wii, DS and 3DS, and played most of the leading Nintendo-made games on those consoles, you've seen pretty much all Nintendo has to offer on Wii-U.
New Super Mario Bros - check. 3D Mario - check. Mario Kart - check. Pikmin - check. Smash Bros - check. Wind Waker is brilliant, but it's the same game! Check, check, check. I'm sure Splatoon is great fun, but it's not a system seller.
Nintendo doesn't need ports of Assassin's Creed or Call of Duty or Watch_Dogs. But it does need third parties making exclusive games that you can't get anywhere else.
That's what made previous Nintendo consoles - specifically the Cube and Wii - into perfect "second console" purchases. Great for the family; experiences you can't get anywhere else.
Nintendo's biggest problem now is that I can get those experiences somewhere else. Not the PS4 or One - it's on my previous-gen consoles and handhelds. Wii-U needs new Nintendo franchises or at the very least, old ones turned into something completely different, like Metroid Prime did.
I really do hope that Nintendo spark returns. I may skip on the Wii-U, but I'd love to be pulled back in day-one when it's successor arrives. Reply +12 -
Eurogamer vs Tom Bramwell
Lovely stuff. That was a great read and I do just want to say thank you, Tom, for everything you've done for my favourite website since I started reading it in 2002... Now there's a scary thought!
Most of all though, this:
"That dynamic did exist for a while with websites in the days before social media - people would come to Eurogamer and get to know the writers and the community and become part of it. "
This absolutely sums up what hooked me on EG in the beginning. The fantastic community of readers and writers coming together to share in a love of video games and gaming culture.
It felt unique and special then and I think it's perhaps something that is unlikely to get replicated ever again for the very reasons you say.
Anyway, I definitely feel privileged to have been part of EG's early community and I know I will still be along for the ride in whatever EG - and Tom Bramwell - do next.
Best wishes guys. Reply -1 -
Who needs games: PlayStation 4's first year
I bought my PS4 shortly after launch (Killzone bundle) and never regretted it for a moment. With the sole exception of Dark Souls II, all my game purchases in 2014 have been for my PS4.
Killzone was okay. Infamous: Second Son was great, and both look spectacular. I'm playing First Light now and having a great time being back in that Universe again.
Sure, I am still waiting for the PS+ edition of Driveclub that they promised, but equally, I've never been short of things to play. PS+ has delivered some really good games, right from Resogun, via Outlast and Velocity 2x. Sure, a big name retail title will be nice when it finally comes, but I'm realistic in realising this is still the first year of the console's life. Those games will come.
Also, the third party line-up hasn't been as bad as the article makes out. I'm firmly in the "Destiny is great" camp - I do see the complaints, but I've put more hours into that game this year than any other and enjoyed it a lot, so it must be doing something right. Wolfenstein was another great shooter that warrants a mention. You all know the list - the point I'm making is I've never been short of games to play and the PS4 has pretty much consistently been the best console platform on which to play those games. Reply +6 -
Battlefield 4: The redefinition of Early Access
Just curious, how many other multiplayer FPS games are there with this kind of scale, this month?
I take your point, but I'm starting to think that MP focused games like Battlefield are just not what I want to at any more.
I know it's not fashionable to say it, but I've really enjoyed Destiny. And before that, I'd say I had more fun with Wolfenstein than I did with BF3.
Far Cry 4 looks much more exciting to me than BF Hardline does.
I guess I see scale and scope in shooters in different ways - not that I'm saying other people are wrong. I'm not really that excited for this year's Call of Duty either.
The point is I already have too many games to play and not enough time. MP focused shooters demand a lot of time to get good at and if they're not fun from day one, I tend to think why bother?
For all the valid criticisms of Destiny's End Game, at least it was great fun getting from levels 1 to 20, and I'd much rather it was that way around. Reply +3 -
Sorry, but I think DICE - and the Battlefield franchise - have lost me, and there's no going back.
Bad Company 2 was without doubt my favourite MP shooter of the last generation. I don't really recognise that description of the Medic class being unbalanced. I thought all the classes were fun to play, and there were plenty of points to be had resupplying ammo or fixing up vehicles as there were healing people. Unlocks felt like true rewards, not just reskins of something I had 5 levels ago with minimal stat differences.
But the main thing was the maps. They were just so beautifully designed, memorable, balanced and fun to play, and they worked well for both squad players and the lone wolf.
Then Battlefield 3 came along with possibly the worst single player campaign I've played in a big budget shooter. And the MP - on console at least (which was where I played it) - was a massive step backwards from BC2. The maps were too big and running for 2 minutes real time just to get to some kind of action and then getting killed instantly by some sniper you never even spotted, only to have to run back all over again, was tedious. Jets were a waste of time. The classes didn't feel as fun to play either - the same features were there, but their abilities were kind of in the wrong order. "Features" like suppression and flashlights just made everything less fun when you were on the receiving end, with no real entertainment worth when you used them yourself.
So I skipped BF4 at launch and all the stories of how broken it was over the past year has meant I've never felt like picking it up. Now it's a year old, there's no way I consider it worth �40+ when there are so many new games due over the next month. An unlikely appearance on PS+ is about the only chance I'd play it now. Reply +43 -
Editor's blog: I'm leaving Eurogamer later this year
Wow. I genuinely thought this day would never come!
Since I started reading Eurogamer in 2002 - waaaay back in the days when the comments under each article were routinely hijacked by the community for wildly off-topic chat - there have been two main things that have kept me coming back to read the site:
One was the fantastic community of intelligent, witty and delightfully fanboy-free commenters and posters. In fact, I'm not even sure I knew the word "fanboy" back then...
Second was the first class quality of the writing of reviews, previews, news, analysis and editorial.
The first has changed... much as gaming and the internet has changed, I think. I'm far less active in the comments than I used to be and that's partly me and my lack of time in the day to post, but it's also the nature of all things internet. Many voices clamour to be heard, and it's harder to pick out the ones worth listening to.
But the second reason has never faltered and I still make Eurogamer my #1 web destination today. That's no mean feat, considering how many websites have come and gone in the past 12 years...
And I do believe that a large part of that is down to Tom Bramwell's editorship and contributions over the years. So, cheers Tom. Thank you for everything and very best wishes for your future endeavours.
And, of course, welcome Oli to the Editor's chair!
Here's to the start of the next 15 years! Reply +1 -
Microsoft UK confirms it is behind cheeky Destiny fragrance ad
I suspect this will disappear very quickly. Even if Sony and Activision don't set their lawyers onto this one pretty quickly, a simple trade mark search reveals the word "Destiny" is (unsurprisingly) already trade marked for perfumes and has been owned by L'Oreal since 1971... Reply +16
Xbox boss Phil Spencer makes case for Tomb Raider exclusivity deal
Sorry Phil, I'm not buying it.
Microsoft doesn't have an Uncharted-type game in its first party portfolio? Nor did Sony at the start of the PS3 generation. They made one. And then the same studio made The Last of Us as well.
Invest in talent - the games will come.
Dead Rising, Ryse - I get that. They were new IPs that might not have been made without Microsoft's money. Do invest in stuff like that.
Tomb Raider wasn't like that. It's an established franchise; the game was getting made anyway. Your money will help, I'm sure, but it could have been put to better use securing a game that otherwise might not get made.
And finally, be honest with consumers - all of them. If it's a timed exclusive, say so. Don't use weasel words because it just pisses people off.
The worst part about all this, is that Tomb Raider is the only thing anyone can remember about the Xbox conference at Gamescom. All this for a game that's not about for over a year? Is it really worth it? Reply +13 -
Not for everyone: exploring the strange pleasures of exclusivity
Great article.
It's become harder and harder to find great rarities in gaming though. I don't really buy into wilful obscurity - it usually means it's shite. Pretty much everything worth having in modern gaming is now available whenever you want it at the click of a button.
That, I think, is why we've seen Activision complaining about a drop in pre-order numbers. There's just nothing really that desirable about 99% of the DLC bonuses; the extra tat thrown into most "special" editions is not worth the premium in price, and the excitement of getting something DAY ONE is not what it used to be. Plus for me, DAY ONE is far less important than being able to pick up the same game in a month or two for half the price. I know I'll always have my PS+ backlog to keep me entertained in the meantime.
Then again, it doesn't seem that long ago that I bought Demon's Souls on import - the hype and excitement around that game was, of course, entirely deserved, but the lack of a formal release over here meant there was a real sense of excitement at being able to experience The Game They Didn't Want You To Play (in Europe) and the community that grew up around the title, with its wikis and camaraderie and forum chatter. I think that thrill was in large part due to the feeling of being in an exclusive club of importers.
Animal Crossing on the Gamecube did something similar, I seem to recall.
I think it's both good and bad that it's probably very unlikely we'll see the likes of that again. Reply +3 -
Newspaper report linking stabbing of Leeds teacher to Dark Souls disputed
Usual Daily Mail bullshit...
However, Dark Souls is rated PEGI 16 so even if there was any truth in this story (which there isn't) it's not the game's or the developers' fault someone under that age was allowed access to it.
Bullying drugs and depression are anyway far more likely culprits for this terrible tragedy. Reply +10 -
10 million posts and counting in the Eurogamer forum!
Great stuff. 10 million posts? Wow. And yet really good to see plenty of names I recognise from the old days. It's funny to think back to the days BF (before forum) when everyone just posted their chat and hooting underneath the news stories...
EG is still by far the best gaming site on the web. Reply +1 -
Report claims PS4 launch title Driveclub delayed until 2014
Not good news for Sony, but let's face it, this game was hardly likely to make a serious impact on the charts or make lots of money for Sony - of all the people I know who have pre-ordered a PS4, only one was looking to buy the retail version of the game. Everyone else was going to play it for free via PS+ and then see.
Killzone is still the big first party game, it's what is packed into most of the bundles and it's what matters.
I'd still like to see Sony announce an alternative PS+ game though - much as I am looking forward to Resogun, dropping DriveClub without replacing it would look bad. Knack seems the most obvious candidate.
I suppose the other option is that Sony / Evolution focus on getting the PS+ edition of the game ready for release on launch day and then the full retail edition can follow on later. All effort goes on getting the core engine working well, and the finishing touches can be applied to the extra cars and tracks after the "soft" release on PS+.
Whatever, I expect the delay in Sony replying is so they can put out a definitive message to say when the game will release, and what this means for PS+ subscribers. Reply +3 -
Digital Foundry: the complete Xbox One architects interview
Interesting stuff, but it still comes across to me as Microsoft on the defensive. Xbox One is outclassed by PS4 at a pure technical level. Period.
Talk of power consumption or efficiency is moot for most consumers - it's plugged into the mains. I don't care how much power it draws (sorry all you environmentalists!). I have a 750w PSU in my PC and it lets me put pretty much what I want in my PC case. That's a good thing. More power is better if it lets me have faster/better kit.
Second, this concept of "balance". I get that - it makes no sense to boost one area of the hardware, if something else can't keep up, but it seems to me that everything in the Xbox One design is pegged back to the DDR3 RAM.
The ESRAM might be fast, but there simply isn't enough of it in 32MB. As you say in the article, four 1080p render targets is 48MB, so developers have to use the DDR3 - they can't rely on that fast RAM all the time. Or - as seems to be the case with Ryse - they opt for a lower-than-1080p resolution (such as 900p) in order to cram those renders into the ESRAM. Is that fair?
So I get the point about "balance", but it just seems this design opted for DDR3 from the beginning and worked from there, choosing the ROPs, CUs and whatever to balance with that.
The net result seems to be a machine that is already struggling to realise the level of quality gamers expect and demand from a next-gen console. Reply +86 -
Battlefield 3 shipped with "the worst set-ups ever"
If they'd just remake Bad Company 2, keep the same classes, the same broad unlock system, the same size maps (please, massive maps are all very impressive, but they're fucking boring to navigate) and the same level of destructibility, it would be the best shooter ever.
Jets were crap. I wouldn't miss them.
Sadly, everything I read about this seems to indicate it's more like BF3 instead... Reply +8 -
Vanquish retrospective
Such a good game.
Like some others, I actually had far more fun playing it on easy, sliding around and doing cool things in slow-mo.
I really should play it again. Reply +4 -
Xbox One dashboard demoed in video leak
So... basically the Xbox One dash is just like Windows 8. Reply +17
Killzone: Mercenary review
7/10 is slightly disappointing, and considering you say this is "a new benchmark for portable shooters", it's hard to see what could have been done to justify a better score.
To be honest, I had no problems whatsoever with the controls in the Beta - they felt pretty much spot on in terms of accuracy and speed of movement, which is pretty good considering it's on a handheld. But if you can tweak the sensitivity, surely that shouldn't be an issue?
Checkpoints? Considering you can just pause and put the Vita into standby any time you like, that's hardly a concern either.
Plus it looks superb on that OLED screen.
As for the campaign, who cares if it does a Call of Duty? Surely all shooter campaigns these days are just training for the MP.
I can't wait to play Warzone. Reply +20 -
Mind the stopgaps?
I feel bad for Ascension. Yes in narrative terms it is clearly a stopgap title for the God of War series, but in technical terms, gameplay and puzzle design, I thought it was a real step forwards. It's a great game and well worth playing. Being a stopgap doesn't have to mean it's bad. Reply +15
Who believes what?
Lovely article which sums up - in my personal opinion - why, when it comes to games, Sony and Nintendo are the companies to watch. And indeed, why they always have been.
That's not to say Microsoft hasn't contributed - but it's clear MS's expertise is in systems and network infrastructure like Xbox Live, but much less so in the actual games.
That's important - even the most resolute Sony fanboy must recognise that Sony would not be in as good a position as it is today without Microsoft creating and curating Xbox Live and setting standard in terms of Achievements, Friends lists and so on.
Is connectivity and evolving games the next industry shake-up? Right now, I'm not so sure, but then I imagine most commentators would have had a hard time predicting the explosion in online play and importance of the MP mode in games that occurred since 2005.
It could well be that "Evolving" games is the next Xbox Live.
Or it could be that Evolving games is the next Kinect.
Xbox One seems to represent that bet. Reply +7 -
Microsoft reverses position on Xbox One DRM
Great decision by Microsoft - not like they had much choice if they didn't want the Xbox One to bomb, but still. I really thought they'd plough on regardless. Kudos where it's due.
But... I'll stick with my PS4 pre-order.
- �80 cheaper
- No Kinect nonsense
- Less TV nonsense
- More powerful machine
- Playstation Plus!
- Sony's commitment to indie games
Oh, and I get to play whatever masterpiece Naughty Dog makes next. Reply +25 -
Sony's E3 victory was a PR stunt, but PlayStation 4 is still the one to watch
Well I like the opinion pieces. Keep 'em coming EG!
I actually like the fact Sony isn't shaking things up too much next gen. PS3 had its problems at the start, but thanks to free online play and then PS+, not to mention some fantastic first party games and indie exclusives, it ended up my favourite console of this gen.
Most of all, I just feel that Sony is closest to what I want from gaming. I want big blockbuster shooters, action games and racing, but I also like quirky, bite-size indie oddities in between. I want a keen price for the hardware and I don't want a spy camera or onerous DRM check ins.
Sony just delivered. Simple as that. Reply +38 -
A list of every confirmed PlayStation 4 game
I loved the first two Infamous games so am definitely more excited by that than anything on the XBone list. Killzone's MP has always been a lot of fun too - I expect to be playing that far more than CoD or BF4, anyway.
I wouldn't discount Knack either - looks quirky and fun.
All in all, a pretty good list - not stellar, but very solid and you can bank on Sony to deliver on the first party games. We still don't know what Naughty Dog and Santa Monica have in store for PS4 yet, after all. Reply +15 -
Xbox One available this November in the UK priced �429
Day one achievement and DLC? How shallow does Microsoft think its customers are?
And �429... come on, even Sony realises - and has publicly admitted - that its PS3 launch price was a mistake...
I wasn't planning to get one before this conference. I KNOW I'm not getting one now.
Sony just need to come in under �400 - for a technologically superior console as well - and then surely, surely they've won this gen. Reply +8 -
XCOM: Enemy Unknown, Uncharted 3, and LittleBigPlanet Karting are coming to PS Plus' year-long Instant Game Collection
Great update. I played Uncharted 3 on release, but the other two are new to me and I've been meaning to give XCOM a go for some time now.
How any remotely sane gamer can't be looking to give Sony all their money next gen is beyond me. Reply +32 -
Xbox One's used game policies to lay with publishers
Sorry Microsoft, this is still shit.
1. I can only "give" games to people who have been on my friends list for 30 days. So that's the ebay / private resale market completely stone dead.
2. Loaning and renting is not happening - at least not for a while. Bye bye Lovefilm. Considering PlayStation Plus is basically a subscription-based game rental service and is widely regarded by core gamers as one of the best things any platform holder has done this gen, it's shocking that Microsoft hasn't thought this through yet. They clearly have no intention of competing with PS+.
3. Retailers have to "participate". It's unclear what this means, but it seems probably that many indie stores will find "participating" uneconomical.
4. Games can be shared with up to 10 family members. Define "family"? Do they have to live in the same house or can I elect to share all my games with my cousin who lives 300 miles away? Come on Microsoft, we want answers.
5. Regardless of all that, publishers seem to be free to make up their own rules. It seems highly unlikely those rules are going to be any better than Microsoft's.
Every announcement just brings more questions and makes me question why anyone would buy one of these things. All I can imagine is that Microsoft are betting that enough NFL and Call of Duty fans out there don't read gaming websites and it'll be too late once they realise this is the trade-in policy.
My bet? This story will be on BBC Watchdog inside 12 months after the machine launches. Reply +43 -
Namco Bandai confirms March 2014 Dark Souls 2 release date
Yes, yes and YES!
Can't wait for this. My only big question is whether they will make a version for PS4? Reply +11 -
Xbox One second-hand games will charge a fee to play
No used games. Just think about what that means for a moment.
Remember when Sony effectively did this with the PSP Go and retailers basically declined to support it? Remind me Microsoft - how did that work out for them?
The one sliver of hope is that the used game "fee" will represent a discount on a retail purchase, but I very much doubt that will be the case.
(Of course, Sony need to confirm that they're not doing this with the PS4 as well...) Reply +30 -
The Xbox One controller still takes batteries but has programmable trigger-feedback
Maybe you're more organised, but I hate having to hunt around for some AAs to put in my Wiimotes - usually I have to steal them from my kids' toys or something.
I have two Dualshock 3s and basically just alternate between them. When one needs charging, I plug it into the USB port and use the other. It doesn't take long (certainly quicker than rechargable AAs) to charge, so local multiplayer isn't a problem.
Seriously, batteries is soooo last-gen. Reply +13 -
Do me a lemon. Reply +22 -
Sony on Vita: "Sometimes you've had slow starts which have suddenly sprung into life"
I really do want a Vita, but I'm waiting for Sony to cut the price here like they did in Japan, and especially to cut the ridiculous price of the memory cards.
�150 with a game and 8GB (or better) mem card and I'll buy one tomorrow. I promise. Reply -1 -
Beyond: Two Souls special edition includes a 30-minute exclusive scene
Come on, �2.50, maybe �5 extra for the steelbook, soundtrack and early access to what will probably end up as DLC? That's actually pretty good as special editions go. Reply +4
ShopTo refuses to sell upcoming Activision games in row over Call of Duty: Ghosts
Surely the real story here is that even a specialist like Shopto can't make money from Call of Duty any more. The number and competitiveness of supermarket discounts year in, year out, on CoD games means there's practically no point in selling this title at release.
I've bought Call of Duty from Tesco on release for the past 3 years and never paid more than �25 for it.
With Blops 2, I paid �15 - the game plus �25 PSN credit = �50 total, reduced to �40 with an online discount code.
I'm all in favour of Tesco selling me stuff at a loss, but since I like Shopto's service, I'd much rather they didn't bother with this game and made some money instead. Reply +23 -
The quest for Shadow of the Colossus' last big secret
Nice article. Reminds me a lot of Ernest Cline's "Ready Player One" in the sense of a hidden quest within a virtual world. Great book btw.
I'm also really inspired now to give SOTC one more play through... Reply +9 -
Dragon's Dogma title update may corrupt your save, Capcom warns
@Killerbee. On the pawn thing, I believe Dark Arisen pawns are now separate from those in the original game because the old code obviously won't work with the new equipment and abilities on offer in Dark Arisen. That's why there seems to be less Pawn activity.
I've not had any save problems, but I'm glad PS+ is doing my backups for me! Reply +1 -
@Grimner - I played the original game to death and had no hesitation buying Dark Arisen too. It's worth having it on disk just so it doesn't take up space on my PS3's hard drive and it cost me all of �13. I'm happy more people will play Dragon's Dogma because it's a great game that deserved to do far better than it did originally.
Also Bitterblack contains way more than 6 hours of content. I've put that in already and feel like I've got ages to go. Reply +6 -
Dragon's Dogma: Dark Arisen review
Dragon's Dogma was easily my favourite game last year - played it more than any other title - and I can't wait to get my hands on this expansion.
Any newcomer who didn't play the original release would be mad not to snap this up. �13 from Asda online for an RPG adventure that will easily last you 50+ hours - more if you indulge in the side questing - is crazy value. Reply +17 -
Forza and Ryse to be next Xbox launch titles
I seriously think MS need to do better. Forza risks being seen as the same old same old racing, only with prettier graphics and new car models (and that's not fanboyism - I'm bored of Gran Turismo too), Ryse needs to overcome the stigma of being a Kinect game and the promise of third party FPS support is more than likely a reference to Call of Duty and Battlefield - which will more than likely be on PS4 as well.
At least you get the impression Sony are interested in making some new games. Killzone 4 is only one title - I can't wait to see what Naughty Dog have been up to. Reply +6 -
Diablo 3 on consoles: hell or high water?
I agree diablo 3 and Dead Nation are very different games, but I do think that if you're looking for a top-down action game, then Dead Nation is the better bet.
The loot, character levelling (which is utterly linear) and customisation options just aren't very good in Diablo 3. In fact, if those are the features you're looking for, Dragon's Dogma is a far better bet - in a different genre that actually suits and supports those concepts. Reply +3 -
Seems like a fair assessment. I bought it on PC, played through once (Demon Hunter) and I've never been tempted back.
The loot "hook" just didn't work for me. I usually love collecting and upgrading my equipment in RPGs, both in terms of maxing my stats and getting the visual look of my character just right, but D3 threw so much rubbish loot at you that it all became very tedious. By the end I hardly bothered picking anything up that wasn't a yellow "special" item and none of the vendors sold anything better than what I had (unless it was locked out because of my character class or level).
The thing is, without the loot, Diablo is just click, click, click. Fundamentally quite dull gameplay. I swear, even Cannon Fodder on the Amiga had more depth to its combat.
Add to that a pretty crap attempt at a story, and I can't quite work out why the PC game got such positive reviews.
The FMVs were nice I suppose.
Personally I'd advise PS3 owners to look elsewhere. In fact, go and play Dead Nation - heaps more atmosphere, better combat options and definitely more fun. Reply +42 -
UK chart: God of War: Ascension launch sales half that of GOW 3
Shame it didn't sell better, as I've been having a lot of fun with God of War: Ascension.
Yes, it's more "GoW3 part 2" than a fully fledged sequel, and I do wish they'd moved Kratos on to fight some mythical beasts and gods from some other culture, but it's still a lot of fun to play (as GoW always is) and looks spectacular.
I think it's a bit harsh to criticise God of War for being a tired franchise - it's not like CoD or Halo or Assassin's Creed that have had annualised releases. This is only the second God of War game on PS3.
That's not to criticise Tomb Raider though - it deserves to do well too. Reply +21 -
Infinity Blade is free for a week
It's shit. Crap controls, boring, repetitive gameplay like the worst possible MMO grind. Don't bother.
If you really want pretty graphics on iOS, RAGE HD is much better. Reply +3 -
The Halo trilogy, Fez and Dyad outed on the Steam database
Shame Microsoft have nixed any chance of Halo 3 making the transition to PC. They'd probably have got a sale out of me.
Still, the others look nice too. Reply 0 -
PlayStation 4 to launch in Japan and North America this year, but not reach Europe until early 2014 - report
I accept that Europe is more complicated than the US or Japan in terms of distribution, but I can't believe an organisation like Sony would really not be able to overcome that to the extent they have to delay the launch of arguably their most important product this decade - they did with the Vita and Nintendo did with the Wii U... Reply +3 -
I'm not sure I fully buy the delayed Euro launch and "distribution complexities" - Sony already have plenty of European distribution in place for the PS3 and all their other products. How hard can it be?
Maybe they really mean "manufacturing capacity issues" but then I'd still imagine a Euro delay to be a big concern for third party publishers. I mean, EA will probably be putting Battlefield 4 and FIFA 14 on the next gen hardware and Activision the same for CoD. That's just three examples where a huge amount of cost will be sunk into making next gen versions of those games and Sony is going to close off a third of that potential market for another 6 months?
I doubt it. Reply +4 -
PS4 only needs 6GB of RAM to match the next Xbox as it doesn't have the OS overheads. More realistic? Reply +10
Shooters: How Video Games Fund Arms Manufacturers
@PlugMonkey - yeah but how often do you drive your car in GTA or Need For Speed in accordance with the Highway Code?
;) Reply +2 -
Really, really good article. Thank you Simon and EG.
It strikes me that there are really two obvious problems here:
1) It needs to be recognised by far more parents that games like Call of Duty are NOT for kids. The analogy with candy cigarettes shouldn't hold up, but I accept that it does. The US games industry needs to accept more stringent controls along the lines used in the UK where an 18 rating is backed up by law. There is still a big enough market amongst adults for adult games. Kids don't need to be in the target market for CoD.
2) It should not be so easy to buy weapons. Yes the second amendment exists and creates a peculiarly American problem that only they can solve. Obama seems to have the right ideas but will struggle against the NRA and supporters who have their own interests at heart. But everyone surely must see that things need to change.
I hope it doesn't take another tragedy for people to wake up to that. Reply +11 -
Heavy Rain composer Normand Corbeil dies of cancer aged 56
Very sad. The music really made Heavy Rain for me. I've got the soundtrack on my iPod and listen to it from time to time - it's well worth getting. Haunting and beautiful. I hope we do get to hear his work on Beyond: Two souls.
56 is far too young to go. RIP Normand. Reply +6


text:
RAILWAY TECHNICAL RESEARCH INSTITUTE Patent applications | ||
Patent application number | Title | Published |
20140378312 | SUPERCONDUCTING CABLE, AND DEVICE AND METHOD FOR COOLING SUPERCONDUCTING CABLE - A superconducting cable comprises a superconductor | 12-25-2014 |
20140097049 | BRAKE LINING FOR RAILWAY VEHICLES AND DISC BRAKE EQUIPPED WITH THE SAME - A disc brake for railway vehicles includes a brake disc fixed to a wheel or an axle of a railway vehicle and a brake lining configured to be pressed against a frictional surface of the brake disc by a brake caliper. The brake lining includes a plurality of friction members arranged to be spaced from each other, each of the friction members having a surface that faces the frictional surface of the brake disc, a metallic backing secured to back surfaces of the friction members, and a base plate supporting the friction members on the back surface side via spring members. The base plate is mounted to a brake caliper; wherein the friction members are provided in pairs with each pair being formed by two adjacent ones of the friction members, and the metallic backing is a one-piece member provided for each pair of the friction members. | 04-10-2014 |
20100167047 | WATERPROOF SHEET FOR TUNNEL - The present invention is a waterproof sheet for a tunnel containing a base sheet containing a synthetic resin having on a surface thereof a silica-containing surface layer containing silica having a silicon dioxide content of 90% by mass or more in a ratio of from 30 to 200 mg/cm | 07-01-2010 |
20100031758 | ANALYTICAL SAMPLE DRYING METHOD AND DRYING APPARATUS - A soil for metal analysis having a high water content of 40% or more is dried up to 20% or less in water content within a short period of time. | 02-11-2010 |


text:
I'll most likely be using the 200X style as well. Mer Man has it covered vintage wise and just like Moss Man, Stinkor will use the alternate head with the tanks.
Vintage Style - Keeping it original
200x Style - love the tanks
Combination of the two
Keeping it MOC
I'm super excited about getting Stinkor next month. I plan on displaying him in the 200x style because as much as I'm partial to vintage figures, I hate having extra parts lying around. So how are you displaying your Stinkor?
My Trader Feedback: http://www.he-man.org/forums/boards/...mighty-He-Dad!
My Sales Thread: http://www.he-man.org/forums/boards/...-FT-WTB-Thread
I'll most likely be using the 200X style as well. Mer Man has it covered vintage wise and just like Moss Man, Stinkor will use the alternate head with the tanks.
Most Wanted MOTU Classics:
*MotU ~ Multi-Bot/Tung Lashor *PoP ~ Angella/Mermista *200X ~ Roboto/Calix *Filmation ~ Teela Na/Lord Masque
*Play-Sets ~ Snake Mountain/Fright Zone *Vehicles ~ Roton/Land Shark *Beasts ~ Night Stalker/Stridor
100% vintage!
I will be displaying him both ways, in his original classic style and also a custom 200x inspired version of him.
Can I get a "Hell Yeah" for Scorpia!!!
My Trader Feedback thread:
Keeping it old school! Stinkor should not be subject to his own smell. He is the Evil Master of Odors!
"Wheresoever on earth he dwells, man is prey to two weaknesses: the need to pray and the need to love."-Marquis de Sade
"It is not by reasoning or by our understanding that we have received our religion; it is by external authority and command."-Michel De Montaigne
Heretical Vintage Purist and Non-Fan Extraordinaire!
Mostly 200x-ish, but I think I'm leaving the little blue gas mask off.
After the forearms are switched out and repainted, I'll probably mix and match to get the Stinkor I like the best.
I didn't vote since the poll didn't allow me to choose multiples. I will have display 1 vintage, 1 200X, and 1 MOC.
Here's to the crazy ones. The misfits. The rebels. The troublemakers. The round pegs in the square holes. The ones who see things differently. Because they change things. They push the human race forward. And while some may see them as the crazy ones, we see genius. Because the people who are crazy enough to think they can change the world, are the ones who do. ― Apple Inc.
My Trader Feedback: http://www.he-man.org/forums/boards/...mighty-He-Dad!
My Sales Thread: http://www.he-man.org/forums/boards/...-FT-WTB-Thread
Here's to the crazy ones. The misfits. The rebels. The troublemakers. The round pegs in the square holes. The ones who see things differently. Because they change things. They push the human race forward. And while some may see them as the crazy ones, we see genius. Because the people who are crazy enough to think they can change the world, are the ones who do. ― Apple Inc.
I will display him alternating each month.
Top Ten MOTUC wants: Sagitar, Great Black Wizard, Fang-or, Dragstor, Peekablue, Skeletor's Skeleton Warriors, Despara, Evil Seed (all era) w/Odiphus, Illumina w/Sleetah, Lady Slither
I love the 200x look. always felt the merman head was no good even on merman.
Skeleton-Warriors, Ra-Jar, Spinwit, Rock Golem, Evil Seed, Lord Masque, Prahvus, General Tartaran, Hawke, Slob-Boar, King Agho, Hunga the Harpy, Sh'gora, Masks of Power Demons, Nocturna, Lizzor, Horde Wraiths, Sagitar, Crimson Fury, Lodar, Vizar, Angast, Negator, Melaktha, ABC Giants, Stridor
Probably the 200X look most of the time, though I may go vintage once in a while.
Coming Soon. My line of 5.5'' action figures. EonQuest.com
probably use the tanks and not the classic head. Dont know that I'll use that handle bit or the facemask. I'll try it all, I'll play with it to heck when I first get it. I may even use the classic head.
But mostly I imagine it wont be no classic choice/all modern choice. Deinately a mix, even if it is only small. Technically I said to my self, promised really, that since I wanted really bad to use the classic head on Merman but usually cannot (I do switch it out sometimes) I'd use it on Stinkor since it always looked more catlike.
I would have been fine if we only get the obvious vintage head, this is a case where a new head really wasnt neccessary. But since they made it I kinda want to use it. I almost wish they hadnt so I could use the old head with no question.
Also didnt need the handle flange, but cool they included it.
REally happy they got the gun. If had to choose, would want gun not tanks
but really like tanks too.
So again, all comes toword liking choices, and using some but not all.
I'll probably alternate quite a bit. I see his modern head as his angry face, and his 200X gear as upgrades to his armor (perhaps for the 2UB).
Not to sound like a creepy cheerleader for Uki, but it's nice to know there is at least one person on this forum who is extremely positive & friendly all the time. I don't think I could be that nice even if you paid me. If we ever give out awards for "forum member of the month", Uki gets my vote. -Mr. Shokoti
200X gets my vote.
This will actually be the first figure that I display 200x-ish. I always stick to vintage when I have the option but this figure will break that run. The combination of 200X head, tanks, and gun really add to this figure.
Stinkor can't stand his own odor, so the tanks, gas mask, the works if he's ever going to be effective.
99% vintage. I'll probably use the modern head to differentiate him from my Mer-Man, but other than that, vintage all the way.
Even though I won't be using them, I do see how the tanks could be useful for storing/creating a powerful concentrated blast of his "odor". However, I think Stinkor needing a gas mask to protect him from his own smell is pretty absurd.
"Oh Lord, Bless this M&M... and the mighty cockroach I slain in battle to get it." - Al Bundy
I needed multiple choice, I am getting 2, one for my MOSC display, and one to correct the arms and mess with, but he will likely have the 200X head and keep the rest vintage.
Recent.... Lizard Man
Wanted.... NA She-Ra, Jitsu....
Needed.... Dragstor
Oh man, did I forget to use these [sarcasm][/sarcasm] again? Sorry....
Check here for my My collection page, MOTU and more!
I'll be displaying him with his tanks, the modern head and no gas mask. Still not sure if I'll include the small handle on his armor or not. I'm really hoping he doesn't look that bad on hand (forearm issue) A few more weeks and he should arrive
I will be displaying him with an air freshner.
I prefer the vintage look, but I might get an extra and display both versions.
Not surprisingly, I chose 200X. However, I might get two Stinkors.
Don't get me wrong, I would display the 200X versions of Fisto and Stinkor from the rip and would show them more, but I like the vintage versions occasionally too.
The Blonde Teela (Battleground and Alcala Teela) Thread
MegaGearMax's 200X/MYP Screen Grabs
Sagitar 200X Prince Adam 200X Sorceress Evilseed (MYP)
I'll do both Vintage & 200x loose pose versions for sure. I'll also have one both. Hell..all of them. Man...I just can't wait to open him & release that great Nostalgic aroma. Yes...yes.....


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Publications (11)48.99 Total impact
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ABSTRACT: Primary hyperoxaluria type 1 displays a heterogeneous phenotype, likely to be affected by genetic and non-genetic factors, including timeliness of diagnosis and quality of care. As previous genotype-phenotype studies were hampered by limited patient numbers the European OxalEurope Consortium was constituted. This preliminary retrospective report is based on 526 patients of which 410 have the AGXT genotype defined. We grouped mutations by the predicted effect as null, missense leading to mistargeting (G170R), and other missense, and analyzed their phenotypic correlations. Median age of end-stage renal disease increased from 9.9 for 88 homozygous null patients, 11.5 for 42 heterozygous null/missense, 16.9 for 116 homozygous missense patients, 25.1 for 61 G170R/null patients, 31.2 for 32 G170R/missense patients, and 33.9 years for 71 homozygous G170R patients. The outcome of some recurrent missense mutations (p.I244T, p.F152I, p.M195R, p.D201E, p.S81L, p.R36C) and an unprecedented number of G170R homozygotes is described in detail. Diagnosis is still delayed and actions aimed at increasing awareness of primary hyperoxaluria type 1 are recommended. Thus, in addition to G170R, other causative mutations are associated with later onset of end-stage renal disease. The OxalEurope registry will provide necessary tools for characterizing those genetic and non-genetic factors through a combination of genetic, functional, and biostatistical approaches.Kidney International advance online publication, 2 July 2014; doi:10.1038/ki.2014.222.Kidney International 07/2014; · 8.52 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background Primary hyperoxaluria Type 1, an inherited disorder with increased endogenous oxalate production, leads to the development of urolithiasis, nephrocalcinosis and end-stage renal disease (ESRD). Contrary to the general belief that patients diagnosed during adulthood experience a relatively mild course of disease, we were confronted with several cases of ESRD caused by previously undiagnosed primary hyperoxaluria.Methods To study renal and patient survival in relation with genotype, age at onset of disease and therapeutic delay, we performed a nationwide search among all Dutch nephrologists and paediatric nephrologists.ResultsOf the 79 included patients, 38% was diagnosed at an adult age. ESRD was present at the time of diagnosis in 26% of paediatric diagnosed patients versus 52% of adult-diagnosed patients (P = 0.021). Homozygosity for the pyridoxine-responsive p.Gly170Arg or p.Phe152Ile genotype was found in 26% of paediatric diagnosed patients versus 68% of adult-diagnosed patients (P < 0.001). Of homozygous p.Gly170Arg or p.Phe152Ile patients, 48% developed ESRD at a median age of 37 years, compared with 48% in those with other mutations at a median age of 0.5 years (P < 0.001). Of the 16 patients found through family screening, 81% had a preserved renal function.Conclusions The high prevalence of pyridoxine-responsive genotypes and favourabl prognosis of timely treatment warrant early diagnostic screening for primary hyperoxaluria Type 1 in patients with recurrent urolithiasis. This will preserve kidney function and prevent diagnosis of adult diagnosed patients in ESRD.Nephrology Dialysis Transplantation 07/2012; · 3.37 Impact Factor -
Article: Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment.
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ABSTRACT: Primary hyperoxaluria Type 1 is a rare autosomal recessive inborn error of glyoxylate metabolism, caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase. The disorder results in overproduction and excessive urinary excretion of oxalate, causing recurrent urolithiasis and nephrocalcinosis. As glomerular filtration rate declines due to progressive renal involvement, oxalate accumulates leading to systemic oxalosis. The diagnosis is based on clinical and sonographic findings, urine oxalate assessment, enzymology and/or DNA analysis. Early initiation of conservative treatment (high fluid intake, pyridoxine, inhibitors of calcium oxalate crystallization) aims at maintaining renal function. In chronic kidney disease Stages 4 and 5, the best outcomes to date were achieved with combined liver-kidney transplantation.Nephrology Dialysis Transplantation 05/2012; 27(5):1729-36. · 3.37 Impact Factor - Clinica Chimica Acta 10/2007; 384(1-2):184-5. · 2.76 Impact Factor
Article: Primary hyperoxaluria remains undiagnosed in patients with hyperoxaluria and recurrent urolithiasis.
Clinical Chemistry 09/2007; 53(8):1553-5. · 7.77 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The Zellweger spectrum disorders (ZSDs) are characterized by a generalized loss of peroxisomal functions caused by deficient peroxisomal assembly. Clinical presentation and survival are heterogeneous. Although most peroxisomal enzymes are unstable in the cytosol of peroxisome-deficient cells of ZSD patients, a few enzymes remain stable among which alanine:glyoxylate aminotransferase (AGT). Its deficiency causes primary hyperoxaluria type 1 (PH1, MIM 259900), an inborn error of glyoxylate metabolism characterized by hyperoxaluria, nephrocalcinosis, and renal insufficiency. Despite the normal level of AGT activity in ZSD patients, hyperoxaluria has been reported in several ZSD patients. We observed the unexpected occurrence of renal stones in a cohort of ZSD patients. This led us to perform a study in this cohort to determine the prevalence of hyperoxaluria in ZSDs and to find clinically relevant clues that correlate with the urinary oxalate load. We reviewed medical charts of 31 Dutch ZSD patients with prolonged survival (>1 year). Urinary oxalate excretion was assessed in 23 and glycolate in 22 patients. Hyperoxaluria was present in 19 (83%), and hyperglycolic aciduria in 14 (64%). Pyridoxine treatment in six patients did not reduce the oxalate excretion as in some PH1 patients. Renal involvement with urolithiasis and nephrocalcinosis was present in five of which one developed end-stage renal disease. The presence of hyperoxaluria, potentially leading to severe renal involvement, was statistically significant correlated with the severity of neurological dysfunction. ZSD patients should be screened by urinalysis for hyperoxaluria and renal ultrasound for nephrocalcinosis in order to take timely measures to prevent renal insufficiency.Molecular Genetics and Metabolism 09/2006; 88(4):346-50. · 2.83 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria type I (PH1) is a congenital defect in glyoxylate metabolism caused by a deficiency in the liver-specific peroxisomal enzyme known as alanine glyoxylate aminotransferase (AGT). The deficiency is due to mutations in the AGXT gene, located on chromosome 2q37.3, and results in the conversion of glyoxylate to oxalate. The crystallisation of oxalate with calcium results in symptoms varying from a solitary kidney stone to end-stage renal disease with systemic oxalosis. The diagnosis is based on increased oxalate and glycolate excretion in the urine, reduced AGT activity in liver tissue, and confirmed mutations in the AGXT gene. Over 50 disease-causing mutations have been identified in PH1, which are associated with a wide range of effects on the AGT enzyme. Homozygous Gly170Arg or Phei52Ile mutations are associated with a reduction in urinary oxalate excretion upon pyridoxine administration and long-term preservation of renal function when treatment is initiated in a timely manner. Homozygous 33insC and Gly82Arg mutations result in a much poorer prognosis. Mutational analysis of the AGXT gene in PH1 patients can be a useful tool for establishing the diagnosis and choosing an appropriate therapeutic strategy.Nederlands tijdschrift voor geneeskunde 08/2006; 150(30):1669-72. - [Show abstract] [Hide abstract]
ABSTRACT: The 625G>A variant of the short-chain acyl-CoA dehydrogenase (SCAD) gene is considered to confer susceptibility for developing 'clinical SCAD deficiency' and appears to be common in the general population. To determine the frequency of the 625G>A variant in The Netherlands, we analysed 1036 screening cards of 5- to 8-day-old newborns and found 5.5% homozygous and 31.3% heterozygous for the 625G>A variant. An increased blood/plasma C4-carnitine concentration is considered to be one of the biochemical characteristics of SCAD deficiency. To explore the correlation of C4-carnitine levels with the 625G>A variant, we determined the C4-carnitine concentration, as well as the ratio of C4- to free carnitine, in blood spots from newborns, who were detected as homozygous, heterozygous or noncarriers for the gene variant. No significant differences were found between these groups. Our study demonstrates a high frequency of the 625G>A SCAD gene variant in the Dutch population, but no correlation to significantly increased C4-carnitine levels in blood spots taken between the 5th and 8th days of life. This latter observation might be the result of the relatively late timing of neonatal screening in our country, implying that fatty acid oxidation disorders may be missed at that stage. If the 625G>A variant is associated with clinical SCAD deficiency, the high frequency of the variant suggests a possible involvement of SCAD deficiency in the pathogenesis of common disorders, probably in relation to other genetic and/or environmental factors. However, homozygosity for the 625G>A variant might be only a biochemical phenomenon, representing a 'nondisease'.Journal of Inherited Metabolic Disease 06/2005; 28(4):557-62. · 4.14 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria type 1 (PH1) is an inborn error of glyoxylate metabolism with an extensive clinical and genetic heterogeneity. Although over 50 disease-causing mutations have been identified, the relationship between genotype and clinical outcome remains unclear. The aim of this study was to determine this association in order to find clues for improvement of patient care. AGXT mutation analysis and assessment of biochemical characteristics and clinical outcome were performed on patients from a Dutch PH1 cohort. Thirty-three of a cohort of 57 PH1 patients, identified in The Netherlands over a period of 30 years, were analyzed. Ten different mutations were found. The most common mutations were the Gly170Arg, Phe152Ile, and the 33insC mutations, with an allele frequency of 43%, 19%, and 15%, respectively. Homozygous Gly170Arg and Phe152Ile mutations were associated with pyridoxine responsiveness and a preserved renal function over time when treatment was timely initiated. All patients homozygous for the 33insC mutation had end-stage renal disease (ESRD) before the first year of age. In two unrelated patients, a new Val336Asp mutation was found coupled with the Gly170Arg mutation on the minor allele. We also found 3 patients homozygous for a novel Gly82Arg mutation with adverse outcome in 2 of them. Early detection of Gly170Arg and Phe152Ile mutations in PH1 has important clinical implications because of their association with pyridoxine responsiveness and clinical outcome. The association of a homozygous 33insC mutation with severe infantile ESRD, resulting in early deaths in 2 out of 3 cases, warrants a choice for prenatal diagnostics in affected families.Kidney International 09/2004; 66(2):746-52. · 8.52 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria type 1 (PH1) is a phenotypically heterogeneous disease. To date the relationship between biochemical parameters and outcome is unclear. We therefore undertook a national cohort study on biochemical and clinical parameters and outcome in PH1. Review of medical charts of all Dutch PH1 patients, who were identified by sending questionnaires to all Dutch nephrologists for children and adults. Fifty-seven patients were identified. The prevalence and incidence rates were 2.9/10(6) and 0.15/10(6)/year, respectively. Median age at diagnosis was 7.3 years (range 0-57). Seventeen (30%) patients were older than 18 years at time of diagnosis, of whom 10 (59%) presented with end-stage renal disease (ESRD), in contrast to only nine (23%) of those aged under 18 years. Median age at initial symptoms was 6.0 years (range 0-50). In four of nine patients with infantile PH1, normal renal function was preserved after a median follow-up of 7.7 years (range 0.1-16). Progression to renal insufficiency was associated with the presence of nephrocalcinosis, as assessed by ultrasound (relative risk=1.8; 95% CI, 1.0-3.4) and with pyridoxine-unresponsiveness (relative risk=2.2; 95% CI, 1.1-4.2) but not with age at presentation, the extent of hyperoxaluria, or AGT activity. No apparent nephrocalcinosis was found in five of the 19 patients who presented with ESRD. Although more than one-half of the PH1 patients have symptoms under the age of 10 years, PH1 can present at any age. In adults, PH1 presents predominantly with ESRD, which may be due to misinterpretation of early symptoms. Although nephrocalcinosis is correlated with development of renal insufficiency, the latter can occur even in the absence of nephrocalcinosis. Pyridoxine sensitivity is associated with better outcome in PH1.Nephrology Dialysis Transplantation 03/2003; 18(2):273-9. · 3.49 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Hyper-IgD and periodic fever syndrome (HIDS) and mevalonic aciduria (MA) are two autosomal recessive disorders that both are caused by a deficient activity of the enzyme mevalonate kinase (MK) due to mutations in the encoding gene (MVK). The most frequently occurring MVK mutation, V377I (1129G>A), has been identified exclusively in HIDS patients. Other common mutations have been associated with both HIDS and MA. To estimate the incidence of MK deficiency in the Netherlands, we determined the carrier frequency of the V377I mutation in genomic DNA extracted from anonymised newborn screening cards by PCR-RFLP. We found 14 carriers among 2138 analysed samples (1 : 153). Based on the V377I allele frequency of 42% in patients diagnosed with MK deficiency, the carrier frequency of any MVK mutation in the Dutch population can be calculated as 1 : 65. This predicts a disease incidence between 1 in 5196 and 1 in 53 656, which is far more than actually observed. Although under-diagnosis of patients with MK deficiency remains possible, this discrepancy probably is due to a reduced penetrance of V377I homozygosity. Analysis of the distribution of the V377I allele within patients carrying MVK mutations revealed that this was not according to the Hardy-Weinberg equilibrium principle, most probably due to an under-representation of V377I homozygotes in HIDS. Homozygotes for V377I might exhibit a much milder phenotype of MK deficiency or no disease-phenotype at all.European Journal of HumanGenetics 02/2003; 11(2):196-200. · 4.23 Impact Factor
Publication Stats
202 | Citations | |
48.99 | Total Impact Points | |
Top Journals
Academic Medical Center (AMC)
Amsterdamo, North Holland, Netherlands
Hospices Civils de Lyon
Lyons, Rhône-Alpes, France
University of Amsterdam
- • Department of Paediatrics
- • Faculty of Medicine AMC
Amsterdamo, North Holland, Netherlands -
Academisch Medisch Centrum Universiteit van Amsterdam
Amsterdamo, North Holland, Netherlands


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Smithfield Organics is a new organic farm located in Smithfield NC. We have applied for organic certification in July of 2011 and should be hearing back any day now. We currently are growing tomatoes, bell pepper and Anaheim peppers.Along with the produce we grow we also grow plants and annuals such as fall mums. pansies, spring bedding plants and other blooming items. We sell our products at the State Farmer's Market in Raleigh and at the Smithfield Farmer's Market in Smithfield.After organic certification is complete, we will grow produce during the winter months in our greenhouses.
We sell our products at the State Farmers Market in Raleigh. Upon being organically certified we will sell our organic produce there also.
We sell at the State Farmers Market in Raleigh NC
We sell our plants at a roadisde stand on hwy 301 North in Smithfield NC.
We wholesale our plants to area garden centers and landscapers. When ortganic certification is given we will wholesale our produce.
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I just transferred my Irish red ale from prime to the second. Well it smelled fruity! This is my first batch and was just wondering what it should smell like. It looked great! I forgot to take a FG, so I'll just wait a few weeks and find out. I guess my question is what should green Irish red ale smell like? dabber
Primary: Secondary: Secondary2: Bottle: Up Next: Pale Ale, Irish Red Ale
post a recipe, that will help us figure this out. Could be from the yeast.
Primary: Secondary: Kegged: Smokier Smoked Porter
Fruity, flowery and like a dead skunk's fart... Pretty typical smells for a transfer brew. Congratulations on your first batch. Don't worry. It will be fine. Don't be shy about getting in there and stealing a sample for a gravity reading. Just be very sanitary. It's alos a good time to give taste. Though don't try to judge a green beer's taste this early in your brewing career.
*******Check Out My Rolling KegeratorBierMuncher Tried & Trues: Tits-Up IIPA (3-Time Medalist), Black Pearl Porter, Kona Pale Ale, Outer Limits IPA, Centennial Blonde (4.0%), Nierra Sevada (SNPA), SWMBO Slayer Belgian Blonde,
Temperature has a big impact on fruity flavors and aromas. What temp did it ferment at?
I had an irish red smell pretty fruity until it had spent a few weeks in bottles. It turned out okay thought.
It fermented between 68-72 degrees. Is this bad, should I be fermenting at a lower temp? dabber
Temp sounds fine to me, I wouldn't worry about it too much, wait and see how it tastes after it's been in the bottle for a few weeks, until then you won't really know.
Irish red ales have a LOT of grains in it. As long as you had a good fermentation, it will be good. This is the whole thing about the art of brewing. Every batch will be different and new. After time, you'll slowly start to realize what you like and what you don't like. From there, you go on to making your own recipes and then the fun really begins.
Some yeasts are more estery than others. What did you use? Sometimes all it needs is time to mellow it out. I had a scottish ale that tasted like sour apples until it had been bottled for 5 weeks.


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Do You Want "Security Analytics" Or Do You Just Hate Your SIEM?
January 27, 2015 Added by:Anton Chuvakin
Now that I've taken a fair number of "security analytics" client inquiries (with wildly different meanings of the phase), I can share one emerging pattern: a lot of this newly-found "analytics love" is really old "SIEM hatred" in disguise.
Comments (1)
Stealth Mode: Lying in Wait Inside the White House's Network
January 26, 2015 Added by:Wallace Sann
Federal agencies need to become more proactive and aggressive in protecting their biggest assets – their data.
Comments (1)
Dark Technology: Are You (Unknowingly) Putting Your Organization At Risk?
January 21, 2015 Added by:Tripwire Inc
As we go about our daily lives, we are leaving subliminal digital traces behind us from our logical footprint.
Comments (2)
The NERC CIP's Are Not Making the Grid More Secure or Reliable
January 20, 2015 Added by:Joe Weiss
The North American Electric Corporation (NERC) Critical Infrastructure Protection (CIP) cyber security standards were developed to increase the cyber security and reliability of the electric grid. Unfortunately, they are not doing either.
Comments (0)
Microsoft SysInternals is Prone to False Negatives When Testing for Escalation of Privileges
January 20, 2015 Added by:Amit Serper
If we didn't already get the memo in 2014, the Sony hack serves as a harsh reminder of how easy it is for attackers to hide undetected, inside a network for long periods of time.
Comments (0)
Network Segmentation: A Best Practice We Should All be Using
January 19, 2015 Added by:Brent Huston
It would be nice to be able to say that we are winning the war; that network security efforts are slowly getting the better of the bad guys. But I can't do that.
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The Five Things CSOs Need to Know About Software-Defined Security
January 19, 2015 Added by:Carson Sweet
Software-defined security changes the game for the CISO and their teams. Security can now move to being an enabler for enterprises that are taking advantage of the business value offered by cloud services and infrastructure, without sacrificing security or compliance.
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How Verizon and Turn Defeat Browser Privacy Protections
January 15, 2015 Added by:Electronic Frontier Foundation
Verizon advertising partner Turn has been caught using Verizon Wireless's UIDH tracking header to resurrect deleted tracking cookies and share them with dozens of major websites and ad networks, forming a vast web of non-consensual online tracking.
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Don't Trust your Router "Update" Feature
January 15, 2015 Added by:Dan Dieterle
With all the news of router exploits and compromised units being used by hacker groups for attacks, make sure you include installing router firmware updates as part of your scheduled maintenance routine.
Comments (1)
Should Networked Safety Systems be Connected to Control Systems in Critical Applications
January 06, 2015 Added by:Joe Weiss
The interconnected networking of control and safety systems is making these processes much more productive, but more cyber vulnerable, and potentially less safe.
Comments (5)
Let's Encrypt (the Entire Web): 2014 in Review
January 06, 2015 Added by:Electronic Frontier Foundation
We've been pursuing the ideas that turned into Let's Encrypt for three years, so it was a great pleasure to be able to share what we've been working on with the world.
Comments (2)
Does Your Valuable Data Belong to Hackers?
January 05, 2015 Added by:Thu Pham
Every organization, regardless of size, is comprised of a variety of sensitive data - from HR and payroll handling medical, financial and personally identifiable employee data to your precious intellectual property. And each of these data types can be sold for a price on the black market, making them valuable to attackers financially as well as for blackmail purposes.
Comments (5)
Addressing Mobile Risks in 2015
January 01, 2015 Added by:Rebecca Herold
We are literally putting more responsibility for the security of our business assets into the hands of our employees.
Comments (1)
3 New Year's Resolutions for Network Administrators
December 31, 2014 Added by:Patrick Oliver Graf
Although it's been a historically troubling year for the cybersecurity community, the advantage of a new year is that network administrators can make a fresh start.
Comments (0)
The Right Security Framework For Your Small Business
December 30, 2014 Added by:Tripwire Inc
A great way to begin to secure your organization is to get a baseline of where you are now and set goals to improve your security stature.
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NSA Published Reports Containing Declassified Compliance Errors
December 29, 2014 Added by:Pierluigi Paganini
The National Security Agency (NSA) has released a collection of compliance reports that details failures and errors in compliance to US laws on surveillance.
Comments (0)
Writing Mandatory Procedures for ISO 27001 /... sarakfeely B on 01-29-2015"http://www.essayscampus.com/Research-Paper-Writing-Services"
- Digital Reputation: Can't Buy it, Gotta Earn It
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- Interview with Accuvant co-founder Dan Wilson
- Suits and Spooks DC 2015: The Agenda - Last Chance to Register
- Thought Experiment: Mandatory Online Banking Security Standards
- Defeat The Casual Attacker First!!
- New Legislation on Threat Intelligence Sharing May Have a Chance
- Google Says It's Not Practical to Fix Flaws in Pre-KitKat Android
- Do You Want "Security Analytics" Or Do You Just Hate Your SIEM?
- Looking Logically at Legislation


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Sale of Channel 6 reflects value of local TV stations
Television reporters and anchors come and go. But TV stations are local institutions whose roots in the community can often date back decades.
Like other institutions today, they are facing challenges. But they also are increasingly valuable commodities because, as Will Rogers once said about real estate, they aren't making more of them. »Read Full Article(2)
Need a restaurant that's open on Christmas?
Whoops -- were you supposed to reserve a table for Christmas? Here are some more restaurants to consider, both nearby and far-flung for you travelers, that are open at night on Christmas Day. (Find last week's list after this latest batch of restaurants.)
Stone Bowl Grill: Korean restaurant serving a buffet from 9 p.m. to midnight Dec. 24, $25. 1958 N. Farwell Ave. (414) 220-9111. »Read Full Blog Post(16)
Aaron Rodgers is off the field, but still on television
Green Bay Packers quarterback Aaron Rodgers may not be on the football field, but he's still on television.
Those "State of Turbulence" State Farm ads featuring Rodgers continue to be in rotation and will remain so as the regular season ends and the playoffs begin, says Tim Van Hoof, State Farm's assistant vice president for marketing. »Read Full Blog Post(3)


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6 results for "coley harvey"
How elite of a pass-catcher is A.J. Green?
Coley HarveyCINCINNATI -- OK, so the question above isn't quite the one ESPN Insider Matt Williamson posed in a piece Monday morning, but judging from his answer, it's clear he holds Cincinnati Bengals receiver A.J. Green in high regard. As he tried to rank t...
Blog | April 07, 2014 -
Leon Hall still targets training camp return
Coley HarveyCINCINNATI -- Most times when Leon Hall walks through the Cincinnati Bengals' locker room these days, reporters are absent. Wednesday was a rare exception. As the cornerback and his booted right foot breezed through around midday after another ...
Blog | December 11, 2013 -
Rapid Reaction: Cincinnati Bengals
Coley HarveyDETROIT -- A few thoughts on the Cincinnati Bengals' 27-24 win over the Detroit Lions: What it means: The Bengals' win showed what we discovered last week: This team knows how to win at the buzzer and in the clutch. With the game on the line, kick...
Blog | October 20, 2013 -
Leon Hall of Cincinnati Bengals suffers Achilles injury
Coley HarveyCincinnati Bengals cornerback Leon Hall left Sunday's game against the Detroit Lions late in the first quarter after suffering an Achilles injury while matched up against Pro Bowl receiver Calvin Johnson.
Story | Conversation | October 20, 2013 -
Bengals at Lions: Numbers Watch
Coley HarveyCINCINNATI -- Among the many matchups to watch Sunday afternoon when the Cincinnati Bengals and Detroit Lions meet at Ford Field will be the battle between the offensive lines. The Bengals and Lions feature two of the NFL's premier pass-blocking u...
Blog | October 19, 2013 -
Green to share stage with mentor Johnson
Coley HarveyCINCINNATI -- It all started with a Bulldog and continued with a Yellow Jacket. During the summer of 2011, NFL players were unable to work out at team facilities and played the lockout waiting game unsure of what their immediate futures held. Mean...
Blog | October 18, 2013


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For those invincible reloaders, is it possible? recessed what 32 cal. bullet inside the cartridge.
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