text:
Hughes Excited About Opportunity to Be Part of Nebraska Brand
Rutgers' 2015 OT Commit Flips to Gamecocks
Michigan Football: 5 Biggest Offseason Goals for Wolverines
Jim Harbaugh has assembled his coaching staff and is working with an " enthusiasm unknown to mankind " to rebuild Michigan. He attended Michigan's home basketball game this weekend and took time for some photos in the student section...
Penn State Football: AD Sandy Barbour Apologizes for '409' Hockey Decal
Penn State hockey honored Joe Paterno on Friday with a "409" decal on their helmets, commemorating his win total after the NCAA restored his vacated victories from 1998-2011 on Friday...
5-Star TE Lauds 'Intense, Awesome' Harbaugh
ANN ARBOR -- Chris Clark knows more about the University of Michigan than most uncommitted recruits at this point.....
QB Commit Torrance Gibson Says He's Going to "Marshawn Lynch the Media"
On Sunday, multiple reports claimed that four-star quarterback Torrance Gibson, an Ohio State commit, was thinking about flipping from the Buckeyes to another school...
Ex-Spartans DE Draws Praise at Collegiate Bowl
It was a familiar story for outgoing Michigan State defensive end Marcus Rush at the NFLPA Collegiate Bowl.....
Big Ten Football: The X-Factors That Could Prevent Ohio State from Repeating
Ohio State successfully pulled off one of the most difficult tasks in modern athletics: winning a college football national championship. What's more, the Buckeyes did it within the confines of the first-ever College Football Playoff...
Ohio State Football: Is 4-Star QB Torrance Gibson Wavering on Commitment?
Torrance Gibson is one of the prized recruits in Ohio State's 2015 recruiting class, but after a weekend visit to Auburn and a trip to LSU on the horizon, he could be wavering on his commitment to Urban Meyer and the Buckeyes...
Ohio Lineman Commits
Ohio Larry Wells committed to Purdue this weekend after being offered a scholarship during his official visit...
3-Star WR Miller Decommits from Illini
"@Admiller_9: I have decided to decommit from the University of Illinois... @DamonSayles " has visited UK .....
Photo: CFP Trophy Delivered to Meyer at OSU
The Ohio State football team now has proof that it won the 2014 College Football Playoff National Championship Game.....
Video: Urban Meyer Tells David Letterman About the Tattoo He's Getting
A ring isn't the only thing Urban Meyer will be getting as a result of Ohio State's national championship.....
Penn State Students React to Reinstatement of Coach Joe Paterno's Wins (video)
Michigan's Jim Harbaugh, on Value of Football
Photo: Penn State Hockey Is Wearing "409″ Decals on Its Helmets Tonight
Fisch Announced as Pass Game Coordinator
Big Ten Future Riding on Jim Harbaugh and Urban Meyer Rivalry
If you want to know why the Big Ten is really " back, " don't look at January 12. That, of course, is when Ohio State capped an unimaginable run to win the first College Football Playoff National Championship...
Michigan Announces John Baxter as ST Coordinator
Paterno Family on NCAA Decision: A 'Great Victory'
Paterno Family on NCAA Decision: A 'Great Victory'
Cardale Jones' Decision Is Everything That's Right with College Football
COLUMBUS, Ohio — With all due respect to the reporters in attendance, the most important question of Cardale Jones' Thursday press conference announcing his return to ...
J.T. Barrett's High School Coach Blasts Texas for Not Recruiting Him
Things That Will Be Different This Offseason, Now That B1G Is Tops
New Husker Coach Mike Riley Says Recruiting Goal Is to 'Own This State'
As the NCAA recruiting dead period lifted Thursday and Nebraska staffers spread out around the country, Husker head coach Mike Riley made the short but important drive up Interstate 80 to Omaha...


text:
The Armo Power Stove is true to its name; it kicks out a serious amount of heat, offering two-channel reheat and windscreen design for efficient combustion and consistent power.
Product Features.
- Compact fold-away design
- Supplied in a carrybag
Technical Specifications.
- Material: Stainless steel
- Dimensions: 9cm x 7.5cm (folded)
- Weight: 308g
- Max power output: 3500W

subset: commoncrawl


text:
Fellows' Blog Archives
Apprenticeship: All Posts
Photo Blog 1
by Yui Lee | November 24, 2014
These are pictures of my first couple months in Ecuador featuring Fellows, families, and Ecuadorian nature.
The banner is from a road trip I took with my family and their families to Puyo in the Pastaza province.
2. The view of Mt. Chimborazo from the rooftop of my house.
3. One of my workplaces: the school, La Escuela Milenio. 4. A trip to Lake Atillo with Fellows Alcy, Bailey, and Alcy's co-worker/our guide, Angel. 5. A trip to Baños with Fellow Alea and her family. 6. Christmas tree in our house in Guano. 7. My sister and I at…Read the rest »
3. One of my workplaces: the school, La Escuela Milenio. 4. A trip to Lake Atillo with Fellows Alcy, Bailey, and Alcy's co-worker/our guide, Angel. 5. A trip to Baños with Fellow Alea and her family. 6. Christmas tree in our house in Guano. 7. My sister and I at…Read the rest »
A Glimpse of Lagoa do Peri
by Kendall Yee | November 24, 2014
Have you ever seen an episode of National Geographic and wanted to jump through the screen to be right where they were? Or look through their magazines in awe and wish it was you visiting such a wondrous part of the world? As I was kayaking in Lagoa do Peri, it became surreal to me that I was not in one of these episodes or articles – but I was living in one. The beautiful community of Florianópolis, Brazil.
This past week, I finally got grounded with my apprenticeship at Projeto Lontra, a conservation and observatory for rescued otters who…Read the rest »
An Average 24 Hours
by Rachel Swartz | November 21, 2014
Wake up at 5:30AM.
5:30AM-6:15AM: Generally spent washing clothes in Rio Napo.
6:15AM-7:00AM: Breakfast. Usually a combination of rice, eggs, bread, plantain, and of course, guayusa.*
7:05AM-3:30PM: Off to work at Sinchi Warm. There is no such thing as an average day at Sinchi Warmi. Potential activities include:
- Organizing our artisanship displays.
- Jungle Walks! Learning about indigenous practices with native plants.
- Occasionally translating for non-Spanish speaking tourists.
- Cleaning the cabanas.
- Feeding TING-TING! Sinchi's pet huatusa.
Festivities of Cuenca
by Aliya Habib | November 21, 2014
Fridays nights are usually spent in the yogurt room outside the house. Two huge vats await my host mom and other women, ready to turn plain yogurt into delicious concoctions. This Friday night was a little more special because in two days, it would be the Independence Day of Cuenca and we were in full production. With a little over 40 liters of milk, yogurt had been forming since morning. With the unveiling of the pots, the process had started. Marmalades were being blended into the plain yogurt and then bottled, color coded, and labeled. Into the night we had…Read the rest »
The Most Important Choice
by Bennett Quintard | November 21, 2014
A few weeks ago I started my apprenticeship at an organic finca (farm) about 20 minutes outside of my community of El Juncal. Below are my first two experiences at my new job:
Experience 1:
Due to my decision to stay up late the night before, I was running on six hours of sleep as I trudged towards the bus stop for my first day of work. Even though I arrived at the agreed upon 7:00 AM, my new coworker arrived to meet me there around 7:45 AM. By the time we got to the farm the hot Ecuadorian sun…Read the rest »
by Georgia Reid | October 7, 2014
[Wiser – Old Man Canyon, Phantoms & Friends E.P.]
Monday, the 6th of October, marks the beginning of my sixth full week here.
The first three weeks in Quito (the capitol city of Ecuador) I lived with a host family, attending language school and training seminars, squeezing in bits of exploration as I could. I summitted Volcán Pichincha, at 15,796ft above sea level, pushing the personal limits I thought previously existed a little bit further. I found a little, unassuming coffee shop where the owner, Gladys, imports green beans and roasts them herself in-house; accompanied by her homemade tamales and…Read the rest »
Year In Review
by Russell Gens | July 1, 2014
The old cliché tells us that a picture is worth a thousand words. As painful as it is to hear this trite little expression, I think that it holds true. As such, I thought that for my last blog post of the program cycle I would throw together a little gallery of some of my favourite photos from the year to provide a concise little window into the past eight months of my life. Enjoy!
Party Time
A local wind band comes out to celebrate the festivals of San Miguel, the patron saint of the town of Puela. The…Read the rest »


text:
Users Online Now:
Who's On?
Visitors Today:
Pageviews Today:
Threads Today:
Posts Today:
Join Our:
GLP Poker Rooms
Check Out:
GiveMeGossip.com - Gossip Forum
Donate To GLP
Adv. Search
Back to Forum
Back to Thread
Message Subject
Why are we still waiting ?
Poster Handle
Post Content
I am waiting because I live on the streets without a single cent to my name; and I don't intend to invest myself into the structure which is on the verge of collapsing.
Now, if there was anyone interested in seeing things be corrected; the unfoldment of timelines within the spatial field - then I might once and for all be out of this 'holding pattern' / 'null zone'.
I am not going to enslave myself under the auspices of the planetary power pyramid, I would rather suffer & live on the streets - eat out of the trash.
I wait for you to wake up; I did my work; have given of my self essence freely - asking for nothing in reciprocation; there simply isn't a support structure that exists upon this planet for people like mysef ...
I work for those who designed the core at the central axis of the entirety; which the entirety emanates out of.
Their payment plan doesn't exist upon earth at this time ...
I've done my job otherwise, it's a thankless pursuit.
link to uenc2012.blogspot.com
Agent144/Unimatrix0 963968
It may be thankless now. but you are not alone. i may not be on the streets but i will be with nature totally soon. And so will you. You can be with nature also, and live with the growing culture now. You know where to find them. Why wait on the streets when you can meet in the woods bro?
Please verify you're human:
Reason for reporting:
English speaking soldiers in Ukraine and 20 other things you should know
Smoking gun' Benghazi documents finally obtained
Your home appliances will soon be remotely controlled by the government
The Shemitah: The Biblical Pattern Which Indicates That A Financial Collapse May Be Coming In 2015
Plan C: The Top Secret Cold War plan for Martial Law in the USA
Vitamin D combined with exercise is crucial for reversing insulin resistance in type 2 diabetics, study shows
$100 Trillion American Economic Collapse
New Strain of Pig Virus Affects Minnesota Farmers
Scientists Debate Whether Solar Lull Could Trigger Another 'Little Ice Age'
CDC's Own Data: Vaccine-Infant Death Link
Global Warming Mounting Weird Comeback in 2015 - Agenda 21 Looming
Millennials: Escape the Credit/Debt Matrix
Public Water Fluoridation Being Challenged in Dallas
Cali Doctor Says, Don't Vaccinate Children
Supreme Court: Cops can do illegal things if it's an honest mistake
Ferguson Scared the Super-Rich So Bad They're Planning Exits
Obamacare program costs $50,000 in taxpayer money for every American who gets health insurance, says bombshell budget report
As The Middle Class Evaporates, Global Oligarchs Plan Their Escape Form The Impoverished Pleb Masses
Justice Dept spying on millions of US drivers - report
2.7 Magnitude Earthquake Shakes Up Downingtown, Pennsylvania
US Pacific Fleet Commander Drops Bombshell About Obama and Muslim Brotherhood
"Communist Party USA" Leader Drops Bombshell About the Democrat Party
State Of Maine Kicks 6,500 People Off Of Food Stamps
Think the New Underwear You Buy Hasn't Been Worn Before? Think Again.
Anchor Gives Obama The Finger and looses her job


text:
The Securities and Exchange Commission late Tuesday released guidance on how companies should comply with the agency's conflict minerals reporting rules in the wake of a U.S. court decision that struck down key provisions of the rule.
The number of accounting-related securities class-action lawsuits filed last year was almost unchanged from the year before, but that could shift as U.S. Securities regulators ramp up their focus on finding accounting fraud.
Just 47 accounting class actions were filed against companies in 2013, up from 46 in the previous year, according to a study by economic consulting firm Cornerstone Research on Tuesday.
In anticipation of new regulations, companies have instituted a wide range of so-called clawback policies, with no two exactly alike, according to a report issued to clients on Thursday by PricewaterhouseCoopers LLP.
Janet Yellen isn't sure if the recent stretch of bad weather is to blame for the soft economic data over the past few weeks. "A number of data releases have pointed to softer spending than analysts had expected," the Fed chairwoman told members of the Senate Banking Committee yesterday. "That may reflect in part adverse weather conditions, but at this point it is difficult to discern exactly how much." The Fed's uncertainty likely puts its policy plans on cruise control for now, meaning continued reductions in monthly bond purchases unless the weak data persist and change the officials' view about the economic outlook, write the Journal's Jon Hilsenrath and Pedro Nicolaci da Costa.
The IASB wants to clean up a category in companies' earnings statement that can obscure the true profit-and-loss picture. "Other comprehensive income," which includes items initially excluded from net income in a particular accounting period, has gotten a reputation as a sort of dumping ground where companies are allowed store information that would be damaging to earnings. IASB Chairman Hans Hoogervorst said in a recent speech in Tokyo that the board may restart its efforts to improve financial-statement presentation guidance in this area and bring more "discipline" to the way companies decide what is classified as profit and loss or other comprehensive income, CFOJ's Emily Chasan reports.
New reporting requirements for over-the-counter derivatives trades in Europe take effect on Wednesday, but companies are still uncertain about whether or not the regulation applies to them, according to a survey.
The European Market Infrastructure Regulation, known as EMIR, makes it mandatory for European and multinational companies to report over-the-counter and listed derivatives transactions with an EU-recognized trade repository.
The toughest challenge for companies hoping to capitalize on big data may be finding people with the know-how to unlock its value. Executives and recruiters point to hiring strategies that can get a big-data operation off the ground: They say they look for specific industry experience, poach from data-rich rivals, rely on interview questions that screen out weaker candidates and recommend starting with small projects, writes James Willhite in today's Marketplace section.
The CFO Report provides original real-time reporting, analysis and commentary on news and trends of critical importance to chief financial officers and other senior corporate finance executives: accounting, tax, regulation, capital markets, banking, management and strategy. The CFO Report is a core component of CFO Journal, which aggregates articles and data from The Wall Street Journal and other premium sources. Contact our editors with news items, comments and questions at: firstname.lastname@example.com.
Learn about the CFO Journal editorial team.
Upgrade your WSJ subscription to include CFO Journal for just $10/month. Don't miss your daily briefing on critical news most relevant for corporate finance professionals, including:
Add CFO Journal to your WSJ subscription at no additional cost. Don't miss your daily briefing on critical news most relevant for corporate finance professionals, including:
Add CFO Journal to your existing WSJ Digital subscription. Don't miss your daily briefing on critical news most relevant for corporate finance professionals, including:
CFO Journal is your definitive destination for news, analysis, and data most relevant to financial professionals, including:
Add CFO Journal to your WSJ Professional subscription at no additional cost. Don't miss your daily briefing on critical news most relevant for corporate finance professionals, including:


text:
It's wonderful to have Sunset Strip to give my Lomographs a touch of orange AWE-TUMN-NESS!
A few weeks ago, I ran into this Lomography product in the Lomography page. Like no other X-Pro film, the orangey-yellowish tone of the Lomographs caught my eyes, and I quickly made my way to Singapore Lomography Gallery Store to get myself a pack while stock last. Loaded with my favourite La Sardina camera, I began my journey with this lovely film.
I tried my best to test the film in all kind of conditions, from multi-exposure,
to long-exposure, love light streams!
With flash,
and some landscapes. It is interesting for the sky to remain a slight blue while, the orange tone cast over the lower part of the photo.
Other than the unique 'Autumnic' effect, the film is actually capable of produce a massive grains in low-light or cloudy condition.
It was a cloudy evening, me and a friend of mine were visiting Marina Barage, and I took a few shots with 'B' mode, for roughly 1 1/2 seconds, as the clouds were really heavy. Surprisingly, the results came out outstanding from the others. As it was no yellow or orange, instead there are a tint of greyish-blue.
This film actually resembles its ancestor, Lomography Redscale, while Sunset Strip distinguish itself with its stronger contrast and dramatic color tone. It is a fantastic film and I am looking forward to expose some more rolls.


text:
According to the Ministry of Foreign Trade, more than 80% of the UAE's private sector is comprised of SMEs, with around 200,000 companies currently in operation. The UAE Ministry of Economy recently revealed that SMEs contributed 60% of the national GDP in 2011.
"We need a powerful, competitive SME community across the UAE in order to maintain the country's fantastic growth and continue to create desirable and sustainable jobs," said Mahmoud Nodjoumi, CEO and Founder Nexus Group.
"Sometimes businesses in the region grow at an incredible rate and many aspects of company insurance are not fully understood until a problem arises. We must do everything we can to ensure that those contributing to the UAE's economy are equipped to succeed in the present business climate and to develop in the future."
Insurance specialists at Nexus Insurance Brokers believe that the most common problem faced by SME business owners is the sheer range of insurance that may be required by a business.
"True success stems from knowledge," added Nodjoumi.
"Those that do not have a full understanding of the insurance market can get caught out, so it is best to seek counsel from an independent financial advisor who can undertake a management exercise, which is usually free, and then offer advice based on a real understanding of the business."
Among the options open to SMEs is a policy developed specifically to address general insurance needs. This type of insurance can be cost effective and typically includes cover for property all risks (covers accidental loss or damage caused to business property and contents), loss of rent, stock in trade, business interruption (covers loss of business income caused by the perils covered under the property section), public liability, tenants liability, motor insurance, workers compensation, fidelity guarantee, electronic equipment, travel, petty cash, personal accident, goods in transit, machinery breakdown and deterioration of stock.
Insurance cover can be tailored to suit specific needs, but most will require property or public liability or workmens compensation.
"An area that needs to be emphasised concerns cases where people under-declare the value of their assets," warns Nodjoumi.
"Whilst this can reduce the insurance premium paid, it can badly affect the business should they have to make a claim, as they would not get fully indemnified for their loss. A better and more logical way to keep costs down is to ask for options based on a higher deductible, i.e. the first portion of the loss amount you have to bear in the event of a claim," advises Nodjoumi.
"A good investment for any SME is to invest time with an independent financial adviser, who will understand specific insurance needs and make cost effective recommendations for the insurance cover required.
Sep 25 2012 All News
Tuesday, September 25- 2012 @ 12:00 UAE local time (GMT+4) Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of Mediaquest FZ LLC.


text:
WEDNESDAY, Jan. 9 (HealthDay News) -- North Carolina, a tobacco-growing state, does a lot to protect smoking: Its cigarette taxes are nearly the lowest in the country, and it only banned smoking in most restaurants, bars and hotels in 2010. But a newly reported survey suggests that its teenagers aren't fans of tobacco.
More than 80 percent of 3,805 middle-school students surveyed said smoking shouldn't be allowed at home, indoors at work or in cars. Slightly fewer (78 percent) of 3,301 high-school students were onboard with these restrictions, but most still liked not allowing smoking in homes and a few other places.
The surveys didn't ask students about whether smoking in these areas should be legal. And, of course, they can't vote until they're 18, so their ability to push for change is limited, at least for a while.
Still, the results show that "it's very clear, that teens and youth want to eliminate smoking in indoor and outdoor places," said study co-author Leah Ranney, associate director at University of North Carolina at Chapel Hill's Tobacco Prevention and Evaluation Program.
The researchers surveyed students in 2009. "They're aware of the harmful effects of secondhand smoke exposure, and they understand the benefits of smoke-free policies," Ranney said. "It tells you how effective our campaigns were. We are a tobacco-growing state, which makes it more challenging for us to successfully promote prevention of uptake of tobacco or cessation."
Among the middle-school students, 86 percent supported never allowing smoking in indoor workplaces. The numbers for other places were: homes (84 percent), vehicles (82 percent), indoor public places (79 percent) and outdoor public places (63 percent).
Support for restrictions was slightly lower for high school students overall, and lowest for student smokers who did not want to quit. Among this group, 64 percent s
Copyright©2012 ScoutNews,LLC. All rights reserved |


text:
All daytime and evening classes will resume at their normal time starting Thursday morning (1-29-15). This includes all traditional undergraduate and Adult and Graduate classes at all campus locations, including all ECE locations.
Parking on and around campus is limited. Commuter students are encouraged to use public transportation or to carpool. The ENC shuttle to the E. Elm Campus and to the Old Colony Campus will leave the Wollaston T stop at 7:15am and 9:00am on Thursday Morning.
Campus Kinder Haus (CKH) will be closed tomorrow Thursday (1-29-15).
For more details, including a detailed shuttle schedule, go to: HERE
*Please note that unless other wise noted, Institutional Aid is applied to tuition only **In order to receive any federal financial aid program award a student must annually complete the Free Application for Federal Student Aid ("FAFSA") and maintain Satisfactory Academic Progress.
For more information on Federal programs vist these Federal resources: Federal Pell Grant Program, Federal Supplemental Educational Grant, Teach Grants, Federal Work-Study, Federal Perkins Loans and Federal Stafford Loans.


text:
Currently viewing the tag: "James Walsh"
via Lobe Log
Last week I attended an event hosted by the Arms Control Association and the National Iranian American Council on how to make diplomacy work with Iran. I wrote about it here. Keynote speaker Zbigniew Brzezinski was the last to speak and showed up minutes before he took [...]
En Español
The Latest
From IPS News
- Zimbabwe Faces Troubling Spike in Cases of Multi-Drug Resistant TB
- After Nine Years of Foot-Dragging, U.N. Ready for Talks on High Seas Treaty
- OPINION: Greece Gives EU the Chance to Rediscover Its Social Responsibility
- General Assembly Holds Informal Meeting on Anti-Semitism
- Forced Disappearances Are Humanitarian Crisis in Mexico
- Obama-Congress Iran Sanctions Battle Goes International
- U.S. May Soon Stand Alone Opposing Children's Treaty
- Three Minutes Away from Doomsday
- A "Rosetta Stone" for Conducting Biodiversity Assessments
- OPINION: Banks, Inequality and Citizens
- Online fundraising for IPS Inter Press Service at Razoo


text:
Senior Member
So this is sorta a guide/theory on Mundo as a top tier character. Basically, Mundo goes where he pleases and this is the guide to get there. Skills: Q: Cleaver...so the purpose of this is to weaken opponents to 40% health so they don't get any crazy ideas of trying to rush you. If you weaken someoen below 40% they typically port out and heal to full so you just endangered yourself. This is doubly dangerous since you probably spent a bunch of your life to do so... Level this up behind... W: Burning agony... So this is a health based spell so 20 health does 40 aoe damage...If you are in the middle of 6-7 minions this does 240-280 dps...at level 1. This is technically the best skill in the game for dps. Technically this adds more dps when used properly then any other maxed out skill in the entire game. E: single target dps...yea..we'll uh...ignore this skill. You can't snowball out of control with single target dps. R: More fuel for W combined with an escape skill. So basically you want to level W > R > Q. E is optional to level beyond level 1 or at all. Theory: You basically automatically win if you have better gear then your opponents if they can't get any gold. This means you have to AOE minions to death so your minions get killed by their tower. Mundo has the highest sustainable AOE damage in the game....at the cost of health. So what would really be nice to start with would be say...2600 extra hitpoints to enable you to do 5200 AoE dps. So how do you start with 5200 extra aoe dps stored up? Duh...start with 13 healing potions... This is enough to shut opponents down every single wave until you get your ult at level 6...see below: Play: Wait tillt he tougher melee minions in front are at 2/3 life. Run in with burning agony exactly between the caster and melee minions and activate Burning agony. Attack each caster once for 50 and do the remaining 200-300 damage with BA. Collect your 150 gold. It helps to have a ranged lane partner so they don't try to jump you. (Nobody's really dumb enough to jump Mundo anyways. Watch your minoins get slaughtered by opponents tower. Opponents get 75 gold. Use a health potion every other wave as appropriate. Net result: you get 150 - 17 (half a health pot) = 133. They get 75. When you have to go back buy basic boots, a sunfire cape, then ninja tabi, then another sunfire, a gaurdian angel, then 2 more sunfires. Once you have your first sunfire cape you will no longer need health potions and this strategy will snowball. Especially since you can move through jungle form area to area. Runes: hp@18, hp quints. Masteries Defensive masteries 21 points, improved exhaust, 8 in utility (improved xp so you hit 6 first and can heal to full with ult before they get theirs and try gank you). Summoner spells: ignite/exhaust (in case they get frisky with you). Also prevents healing/lifestealing end game. Of course, having a ton of armor also stops lifestealing but thats another story. You will probably die a few times...my second game with this strategy (I'm improving atm): Notice Teemo and I got 190 minion kills in a lane and our opponents Kass and Sion got 70...difference of 120 kills @ 26 gold = 3k gold. (Our Sivir owned their spearchucker too in mid but thats another story). http://img19.imageshack.us/img19/3500/mundod.jpg
So uh...opponents get Exec Calling at 1350 gold. But I was making twice as much as they were so I was at 2700 and had a sunfire. So I could just backoff and ult to heal and didnt need as much W to wipe out all the minions anymore. I did think it was hilarious for them to waste 1350 (basically a ton of gold when your getting nearly 0) countering Mundo...especially since I didnt have a single hp regen item and could just back up to ult...lawlz. Try guess how well a carry with exec calling, berserker boots, and some zeals do against a tank spec mundo with exhaust, ninja tabi, and two sunfires...hahahah.
congratulations you managed to go 4/4/8 with a character that has no support skills
sigh...some people just don't understand the snowballing effect of denying 3k gold early on to the opposing team...
Ponies Gonna Pwn
Sigh... some people just don't understand what it means to be pretentious and suggest the worst build possible for a PDPS hero so... sigh.
^burning agony > sadist at early level. It is great for harassment, great for farming, and great for chasing. Not to mention the improvement on survivability. As a physical dps, mundo has no real advantage other than sadist....which become effective as mundo start dying. I'm not saying sadist is not a great skill, but it's more of a bonus dps for when you are finishing your tanking gear and you shouldn't prioritize it asap. Even if you are building mundo as carry and prioritize on damage, burning agony still should be your top pick as it provide a much more reliable form of dps and you will have easier time picking off fleeing opponent (more money = better carry amirite?). finally
Top Teir mundo would be ultra sick had they made the cool change of 30% more healing/regen to the spirit visage meaning enemies would cap out at 20% healing/healthregen reduction making mundo once again more powerful. if u curious end build runes 29 armor pen 6.7 dodge 8,9% cd reduction lvl 18 masteries 9 0 21 summoner spells ghost/exhaust final items warmog ninja tabi force of nature guardian infinity triforce (infinity/triforce are last items after I sell my 2x heart of gold.) the basic stats of this build at say lvl 18 would be 250ish attack damage (with E. spell used) 150ish magic resist 250ish armor just over 4k hp no runes or defense mastery. 450+MS base 550 with ult or ghost. (im between ultimate and ghost im always 500+ ms) Another tip/Item for mundo is Quicksilver sash maybe coupled with cleanse i go into a battle at full life run out into a bush or something in a fient retreat us quicksilver sash/cleanse pop ult get hp back this is of course for teams that spam HP REGEN REduction on you. EVERY SINGLE GAME I USE THE EXACT SAME BUILD. i may choose to build certain items at certain times but i always use the core 2x hearts of gold first every game. if u think mundo is op early game get two hearts of gold on him by 8 minutes hes damage reduction/HP dwarfs all other heros at that point. conclusion you gotta get in on the heros when they are fresh and OP before everyone exploits them and they get toned down. mundo good example and IM sure one day he will be op again but as of this point he isnt as game shattering as he was a few months ago. now AP sion theres an op hero at the moment. and will be until all yall exploit him like mundo was. ps when server comes up ill post a screen shot of my most played champions mundo is one of them
Solution Nine
MUNDO TOP TIER? LOL NO that is all
Malak al Maut
Most pDPS High Elo Mundo players go Warmogs/Frozen Mallet ~> Boots ~> Starks ~> Bloodthirster.


text: The Wolverine: Knight Of Terra wiki last edited by fesak on 09/30/14 02:52PM View full history In the otherdimensional realm of Geshem, Earth-616's Wolverine is recruited by the Shaman, Geshem's counterpart to Professor X, to put an end to the Beast, an alternate reality version of the homicidal Sabretooth. After a horrific and bloody battle, the Beast flees, leaving Wolverine badly injured. Meanwhile, in the capital of Geshem, the Shaman, along with Hector, the Nightcrawler of Geshem, formulate a stratagem to combat the evil Beast against Queen Rain's wishes. On Muir Island, the wolf's head pendant given to Wolfsbane by Wolverine begins to glow with mystical energy inside of her trinket box. Her mind is swapped with that of Queen Rain of Geshem, Wolfsbane's royal counterpart, and the queen attacks Bishop when Wolfsbane's screams draw him to her bedroom. Professor X uses mental telepathy to make Queen Rain sleep, and informs Bishop and Moira MacTaggert that the young woman's mind residing inside of Wolfsbane is not from their reality. Back in Geshem, Wolfsbane angrily attacks the Shaman for stealing her from Earth-616 once again, until she meets Geshem's version of the X-Men, and allows the Shaman to explain that one of Geshem's mystical pools requires bonding in order for the realm's wild magic to remain in check. Wolfsbane learns that she is married to Geshem's alternate reality counterpart to Cypher, while Moira MacTaggert learns in the medlab on Muir Island that Queen Rain is eight weeks pregnant with their first child. The Shaman then requests that Wolfsbane pose as their queen to rally troops against the Beast. The citizens of Geshem band together at Wolfsbane's "royal" proclamation to put an end to the Beast, once and for all. They wage a fierce battle, in which many die at the hand of the Beast. Wolverine succeeds at slaying the Beast's host body, and Wolfsbane meet Queen Rain for the first time. She proclaims Wolfsbane a peer to the realm, and Wolfsbane finally returns to her own dimension, much to the relief of her friends on Muir Island. Wolverine, having fulfilled Queen Rain's request, goes his own way once satisfied that his mission is complete.


text:
The carefree lifestyle at The Oaks of Louisiana focuses on living life to its fullest. Here you'll find a residential community designed specifically for adults 55 and older, with maintenance-free living and an active, healthy lifestyle, one that is surprisingly affordable. In fact, our one bedroom apartments start at $1,563. The Oaks includes independent living, assisted living and total care, all on one beautiful campus. Check out our options, Tower at The Oaks, Garden Apartments at The Oaks, Savannah at The Oaks, Health Center at Live Oak/North Pavilion, plus the wonderful amenities that include our Spa & Wellness Center, MarketPlace and Chapel. Visit us often for the latest developments.
Eighty-seven-year-old Ashley Youngblood had been a resident of The Oaks of Louisiana for just days when he signed up to go on a trip to Dallas to tour the George W. Bush Presidential Library and Museum on the Southern Methodist University campus....Read Story
The Oaks of Louisiana will hold its monthly open house on Sunday, Dec. 14, from 1 to 3 p.m., moving it from the third weekend of the month because of the holidays....Read Story
Copyright © 2015 The Oaks of Louisiana. All rights reserved.


text:
Sorry this item is currently sold out. Please use this discount coupon for an additional 5% off during checkout:
This Burton Patchwork Beanie has a unique earflap design that''s great for the slopes. Made with the fleece lining and all acrylic, you''ll love staying warmer. The Burton patchwork beanie gives you that extra character that''s always fun to wear.
Discontinued Colors


text:
Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
Sort by: Date | Rating | Most Helpful
"OMG this is SOOOOO goood!!!!!!! I'm on a diet right now and I've been wanting a healthy treat that will also be okay for my diabetes. this is it! I omitted the lemon juice and it still came out great! This one's a keeper!!! OMg!!!! I also tried it freezing it in the freezer and it I had it as ice cream, it is GREAT!"
"wonderful! I think it comes out better when you mix it REALLY well. I dont have a blender but I really whipped it with a fork :)"
"These were so so so good!!! I used green raisins and they turned out great!! Thanks for posting!!!"
"This was so delicious and easy!! I used honey and it came out great. This is seriously the best cookie I've ever made!!! :) *****"
"these are pretty tasty considering they are fatfree! Since I am diabetic, I didn't add the brown sugar and I didn't have allspice, but it still tasted wonderful. Thanks for a good cookie!"


text:
The Throne by Edge Palace The Throne - over 1 year ago
"This is a company advertisement highlighting the throne tank made by custom ink." view full details
Operation Gator Roll by Swamp Tour 2013 - over 1 year ago
"The shirts were made to commemorate our buddy's bachelor party in New Orleans. The gator on our chests with the New Orleans symbols were inspired by our planned swamp tour where we saw wild alligat..." view full details
PanAsia with Poreotics Dance Crew by Panasia Poreotics Collaboration - over 1 year ago
"We designed these panda brotanks to celebrate the end of the University of Chicago PanAsia Spring Festival! At our Poreotics Dance Crew Event on May 10th, (they are an MTV ABDC Winner and have been..." view full details
made for me by made for me - over 1 year ago
"I had this shirt made to inspire other to be healthy. after losing a lot of weight i wear this shirt with pride and have encouraged othets to keep going." view full details
William&Mary Club Soccer by Tess Curry - over 1 year ago
"The last day of classes at William and Mary for the Spring 2013 semester, the Women's Club Soccer team wore matching tank tops with our club logo on the front (MCL). CustomInk was great and got us ..." view full details
KBG Weekend Girls by JulesK - over 1 year ago
"The event was Kappa Weekend for our sorority, Kappa Beta Gamma. During the year we all work hard in school, work, and keeping up with service events so we like to take one weekend out of the year t..." view full details
Arizona State Intramural Softball by Joshua R - almost 2 years ago
"This picture was taken following our last game. We definitely weren't the best team, but no doubt the best dressed team (consult picture). I was very pleasantly surprise with custom ink's custome..." view full details
Auburn University Dowell Darlings by Dowell Darlings - almost 2 years ago
"Dowell Hall, located at Auburn University, decided to attempt the Insanity Challenge. This group is now on Day 39 of the 60 day challenge." view full details
Turn Left Yeah by Turn Left Yeah Trophy Girls - almost 2 years ago
"This was a few of our Trophy Girls inside the Daytona 500 right before them and the rest of Turn Left Yeah was filmed by the Travel Channel for a new TV series called Fandemonium." view full details
Pappaw with all 4 grandsons by Heather - about 2 years ago
"I live in a different state than the rest of my family so I made my dad a tank top of my son. Then my sister took a picture of my dad in his top with his other 3 grandsons so all 4 boys could be to..." view full details


text:
I was recently told that the A/C company that installed my unit did not use an approved unit by Nordyne. They installed an un-insulated cabinet model of our natural gas heater in hot-humid attic. ...
Search:Type: Posts; User: ravinred99 Search: Search took 0.00 seconds.
Results 1 to 1 of 1


text:
Hugo, MN, USA < change city >
Photographers (84)
Florists (61)
Bands (52)
Caterers (51)
DJs (45)
Wedding Day Beauty (28)
Wedding Fashion (20)
Invitations (16)
Rentals (15)
Limos (14)
Coordinators (14)
Videographers (13)
Officiants (13)
Decorations (11)
Beverages (10)
Ceremony Sites (107)
Reception Sites (87)
See All Vendors >
Queen Of Cakes
7027 Amundson Avenue
Edina, MN, United States
11 ratings, 9 reviews, 13 weddings
Terri Leckas and the Queen of Cakes staff created a beautiful cake for our weddin...
Pine Tree Apple Orchard
450 Apple Orchard Road
White Bear Lake, MN, United States
Favors, Cakes/Candies
2 ratings, 2 reviews, 2 weddings
We had caramel apples from the orchard for each guest and they were a hit! The ap...
Jessica's Cakes
Minneapolis, MN, United States
2 ratings, 2 reviews, 2 weddings
Amazing - personal service and delicious!
Key's Cafe & Bakery
1960 West Broadway Avenue
Forest Lake, MN, United States
2 ratings, 2 reviews, 2 weddings
BEYOND awesome! We had so many people coming up to us telling us how delicious ou...
Taste of Scandinavia
2900 Rice Street
Saint Paul, MN 55113, usa
Restaurants, Cakes/Candies,...
1 rating, 1 review, 2 weddings
Ruth is fantastic, and the cake was delicious! She was such a pleasure to work w...
Fresh Fields Bakery and ...
1400 Frontage Road
Stillwater, Minnesota 55082, USA
Cakes/Candies, Caterers
1 rating, 1 review, 1 wedding
We had numerous compliments on our cupcakes, and the cost was less than half of s...
Deco Catering
2010 E Hennepin Ave # 9
Minneapolis, MN, United States
1 rating, 1 review, 1 wedding
We had the most unbelievable Scandanavian Torte cake, everybody raved about it.
Truffles And Tortes
72 Nathan Ln N
Plymouth, MN, United States
1 rating, 1 review, 1 wedding
They have a lot of different kinds of cakes so we got like 7 different kinds and ...
Jkb Cakes
New Hope, MN, USA
1 rating, 1 review, 1 wedding
(Ham Lake or Blaine...I think it's Blaine)....very good to work with and excelle...
Cedar Creek Baking Company
22001 Lake George Boulevard
Oak Grove, MN, United States
1 rating, 1 review, 1 wedding
Cherise at Cedar Creek Baking Company in Anoka, MN did an amazing job! She was hi...


text:
Hold down Control (PC) or Command (Mac) key + mouseclick to select more than one option
Rating | Avg. Dinner Entrée |
$$$$$ | Greater than $25 |
$$$$ | $18.01 - $25 |
$$$ | $12.01 - $18 |
$$ | $7.01 - $12 |
$ | Less than $7 |
Food | Value | ||
Service | Atmosphere |
Posted by Calla on 10/17/2010
I went yesterday to John's of 12th to try their brand new vegan menu. Finally, TRADITIONAL Italian food. I was with 5 friends, so we got to try a lot of their food. Everything was delicious from the bruschetta, to the pizza, ravioli, and especially the seitan parmigiana. John's is smart, avoiding all things soy. They use daiya cheese (tapioca based), seitan for scalopini, coconut and nut cream for the fillings of their vegan cannolis (yes, VEGAN CANNOLIS), and coconut creamer for coffee. They also have gluten free pasta one could substitute in pasta dishes. The owner was super friendly and excited to have customers trying out his vegan menu. He sat down and chatted with us for about half our meal--telling us all the ingredients to the vegan dishes, sharing personal stories, explaining that he thinks its only a matter of time before the world is vegan. He was absolutely delightful. For someone who is used to eating cheap, John's was a little pricey. But it's a nice, traditional Italian restaurant, so I suppose that's to be expected.
Posted by looking for amore on 08/16/2010
this is by far the best traditional italian food on the island of manhattan! we ordered the baked clams arreganata, bright and flavorful and tasty whole clams not chopped, the spedino which is simply amazing (one of a kinda!!!! worth every delicious calorie!) as starters. the garlic bread was crispy and great too! i had the shrimp parm for my meal which was amaaazing, and my family was completely delighted by thier dishes as well! amazingly we had room for dessert (these are not small protions people! this is like being fed by an italian grandmother!) and the chocolate cheese cake, key lime pie and panacotta were wonderful compliments to the meal! i reccomend this place for a good old fasioned italian family feast!!!
Posted by George on 04/13/2010
great italian food. Fantastic atmosphere.
Posted by John on 02/17/2010
Although I made a reservation for Valentine's Day over two weeks ahead, it was not honored on arival at the resturant. They just "Didn't have it". It was my error in not getting the name of the person who took my reservation, but more care needs to be taken by the staff. We were finally told that a table would be found for us. And it was. A postage sized table wedged in by the front door. With my wife sitting aginst the wall almost in the lap of the customer at the next table, and me in front of the door. I would have to get up from my chair and push it under the table every time someone came in. Needless to say, we won't be returning to a resturant we used to love.
Posted by Anonymous on 01/16/2010
I went with a group of 8 people and everything was perfect. We all had plenty of wine and great food and walked out paying, with tip, $25 each.
Posted by JAKEREMI on 01/04/2010
Hey, Don't come to JOHNS expecting the trends . This is the place to come for the EGGPLANT PARM that you may remember from your youth. The kind you will not be making at home anytime soon. This place should have landmark status for the atmosphere alone which is the witty and welcoming kind that every NABE in NYC used to have , the EAST VILLAGE is lucky to have this. Bring the family and an appetite and leave the pretensions at HOME!
Posted by John'sIsTheBest on 07/16/2009
This place is a classic New York establishment ... highly underrated in my opinion compared to other establishments of the same calibre. GREAT service, with a professional and classy tie-wearing waitstaff. Homestyle Italian cooking that is exactly what it should be. I don't have a bad word to say about the place. Unfortunately the slew of Italian-Fusion B.S. , or over priced Northern Italian places with corny names that have invaded the city have people fooled on what going out for Italian should be. If you like 'old school' down home Italian cooking, decor and atmosphere reminicient of a better and simplier time, and excellent service that makes you feel like royalty, then this place is for you. I'm not sure if they make their cheese on site (I wouldn't be surprised if they did) but the mozzerella they serve is some of the freshest and best I've ever had This place is for real people , not walking, talking amature food bloggers who are expecting the world every time they sit down in front of a plate. If you want to be reminded of a time where there were real neighorboods in Manhattan, with neighborhood people operating their own businesses based on tradition - instead of these lame corn-ball transplant celebrity chefs - come to John's. Ask for extra sauce if you're ordering anything with their marinara - its that good!


text: Stunning, private, waterfront retreat, designed by famed architect Monteforte is undoubtedly Oceanport's best kept secret. This luxury home features every finer detail imaginable. A meticulous blend of grand scale elegance and waterfront Island Retreat includes pool w waterfall, jacuzzi and 3rd floor deck. Timeless craftsmanship and design, including gas fireplace, hand carved Brazilian wood floors, intricate moldings,and exposed beamed ceilings. Truly grandiose in every way.


text:
26th Feb 2008, 12:16 AM | #1 |
Generic Browser window stretching items in view,
So unless I am mistaken, I'm am almost certain UnrealEd always properly arranged the thumnails of the items in the Generic Browser when you resized the window. I often resize and move it from monitor to monitor, and it keeps stretching, and never arranges itself like it used to.
I'm not sure if this is a 1.2 patch issue or what. Any ideas? |
Thread Tools | |
Display Modes | |


text:
Shahram Gholami
This biographical article needs additional citations for verification. (December 2012) |
Shahram Gholami | |
Born | 1974 (age 40–41) Tehran, Iran |
Genres | Iranian contemporary |
Occupation(s) | Musician |
Instruments | Oud |
Years active | 1995-present |
Labels | Avakhorshid, Ohrwurm |
Shahram Gholami, born in Tehran in 1974, is an Iranian Oudplayer.
Shahram Gholami was born in Tehran, Iran, in 1974 and began studying oud and traditional Persian music at the age of 20. Under the tutelage of Mansoor Nariman, Shahram began recording with composers such as Parviz Meshkatian and Ardeshir Kamkar. Shahram was a member of the Iranian National Orchestra for nine years and subsequently played at various festivals such as the 2003 Sufi Music Festival, Amir Khosro, in India, with the Rumi Ensemble,[1] and Oslo's World Music Festival with the Sarvestan Ensemble in 2006. He collaborated from 2007 until 2008 with the singer Shahram Nazeri. In Europe, Shahram has performed with the Rumi Ensemble, Javid Afsari Rad, Peyman Yazdanian and the Xenia Ensemble, and he performed solo in Paris' Theatre de la Ville, Abbesses in April 2009. After the show, he met Habib Meftah Bouchehri and decided to create the band Solouk Duo with him.
February 2009 marked the release of his solo album, Tolou-e-Kavir, inspired by nature and ancient Iranian fables. His new album entitled "Helheleh" in Iran and "Yell" for the rest of the world was recently released in 2012 with the collaboration of Habib Meftah Boushehri.
- 2009 : Tolou-e-Kavir (solo)
- 2013 : Yell (Solouk Duo with Habib Meftahbouchehri)`
- ^ "Sharam Gholami, Oud". Rumi Ensemble. Retrieved 11 December 2012.


text:
nature posters, scenic posters, sunset posters, landscape posters, new england winter scenic posters, maine winter posters, beautiful sky posters, beautiful clouds posters, shorelines posters, sunsets posters
All prints ship in durable cardboard tubes.
Fine Art America is one of the largest, most-respected giclee printing companies in the world with over 40 years of experience producing museum-quality posters and prints. All of our posters are produced on state-of-the-art, professional-grade Epson printers.
We use acid-free paper with archival inks to guarantee that your posters last a lifetime without fading or loss of color. All posters include a 1" white border around the image to allow for future framing and matting, if desired.
Posters ship within 3 - 4 business days in durable cardboard tubes.
Surrounded by ice and wind blown snow, granite boulders rise above the frozen surface of Meddybemps lake on a cold winter day in Downeast Maine about 20 minutes before sunset. Still illuminated by the setting sun, pastel clouds radiate out from the horizon. Canon 5DII, EF17-40 @17mm. Copyright 2012, Bill Caldwell / ABeautifulSky Photography. Large fine art prints are available up to 72 inches x 43 inches. Featured in Nature Photography Group and Dimensions Group. 2nd place, "Ice and Snow Images" contest, Jan 2014.
I grew up in southern California during the 60s and 70s surfing the waves whenever I could get to the beach. In junior high I took a photography class and I've been hooked ever since. I got a BA degree in photography at Brooks Institute in 1978, but by the time I graduated I realized that I was a lot more interested in the art of photography than the business of photography. So, to pay the bills, I went to work in residential construction with my brother and dad for about 4 years until I decided to pursue my other passion, aviation. I joined the U.S. Air Force and spent 20 years as a combat search and rescue (CSAR) navigator which also gave me the opportunity to travel and see many parts of the U.S. and Europe. Since I retired...
Our return policy is very simple:
If you're not happy with a purchase that you made on FineArtAmerica.com, for any reason, you can return it to us within 30 days of the order date. As soon as it arrives, we'll issue a full refund for the entire purchase price. Please note - Fine Art America does not reimburse the outgoing or return shipping charges unless the return is due to a defect in quality.
Fine Art America sells thousands of pieces of artwork each month - all with a 100% money-back guarantee.
If you've hesitated to purchase artwork online in the past, why not give us a try? You have nothing to lose!
We take great pride in the fact that 290,161 artists have chosen Fine Art America to fulfill their orders, and we look forward to helping you select your next piece!
Customer Service: 877-807-5901
(Call Any Time - 24 Hours Per Day)
All posters ship from our production facility within 24 hours of your order.
Please Wait...


text:
Shop Equipment
Food Service
Vehicles / Automotive
Musical Instruments
Portable Buildings
Computers / Electronics
Sporting Goods
Facilities / Maintenance
Printing / Graphic Arts
eBay #: 350161891904Near Pleasanton, CASold for $569.00
view more photos
Email us about this item
Description:This is a Complete Expresso Cart by Techni Brew International, includes H2O Pump system, Reneka Viva Expresso Machine and five gallon waste water system. They are used and being sold as-is.
Model:Techni- Brew Model RR45 Reneka Viva serial # 09970-C61660
Size:Stand W 55"D 31", H 35" Reneka Viva W 15", D 20", H 22" Techni-Brew Grinder H 24", D14", W 9"
Condition:This item is used and sold as-is. The item did power-on, but NO other functions were tested. May need service and/or parts to make fully operational.
| home | company | services | contact | site map | recently sold | current auctions | coming soon | © Copyright InterSchola 2006 - 2013


text:
'The fringe has invaded the middle'
PUBLISHED: 28 Jun 2013 00:33:10 | UPDATED: 28 Jun 2013 00:33:10PUBLISHED: 28 Jun 2013 PRINT EDITION: 28 Jun 2013Rob Oakeshott sent Julia Gillard a text message 10 minutes before the Wednesday night Labor leadership ballot that her father "would be proud of her".
Already a subscriber? Please login here
Stay with the story for less than $1.90 a day
Read more
People | Rob Oakeshott, Julia Gillard |
Topics | Politics /Federal Politics , Politics /NSW Politics |


text:
Proving the concept behind "iconcept" is still fresh, Art Center Sarasota hit the mark again this year with its high-energy fashion show. With designs by more than two-dozen visual artists, including Gale Fulton Ross and architect Carl Abbott, 2010's catwalk creations were even more provocative than last year.
Thanks to artists Sarah Ford and Suzanne White, bottle caps and pencils have never looked sexier. (Ford crafted a mini skirt out of No. 2 pencils, and White adorned a dress with recycled Heineken beer caps.) Even artist Daniel Petrov's "Mini Body Bag with Noose," made from canvas and rope and inspired by sailboats and executions, was oddly flirtatious.
"I wanted to introduce dark humor to maritime navigation," Petrov said. "I suppose you could wear it to your execution and still look stylish. It's meant to be tongue in cheek."
The event, which kicked off with a performance by Fuzión Dance Artists in Bahamian street parade masks and headdresses, was sold out. Every chair in the house was occupied, and even the stairs doubled as seating.
Hosted by cheeky cable television personality Lorenzo Hubbard, who stepped out in not one, but two, Gucci kimonos, the runway show with a reputation for rowdy dance music and even rowdier fashion had audiences howling for more.
"To get such artistic talent to create this kind of fashion is just fabulous," said Art Center board member Jeffrey Weisman. "It's just such a cool event. We've waited all year for it."
Contact Heidi Kurpiela at email@example.com.
Currently 0 Responses
- Jan
11:00 am - 1:00 pm - Jan
29 Masterworks Series: Enigma
8:00 pm - Jan
30 Start an Artists Sketchbook/Journal
10:00 am - 1:00 pm - Jan
30 The Jazz Club of Sarasota Presents "Jazz at Two" with Kevin Celebi and Harmonic Sanity
2:00 pm - 4:00 pm
Key gets high five from Krauthammer
The night before he was scheduled to speak at the Ringling College Library Association Town Hall lecture, Fox News commentator and syndicated columnist Dr. Charles Krauthammer arrived late Monday night, Jan. 12, for his stay at the Inn on the Beach Resort at the Longboat Key Club. -
OSU victory a gem for Holbrook
Karen Holbrook wore red and black to the Jan. 14 Longboat Key Rotary Club meeting. -
Paul Glosser takes turning 85 in stride
Longboat Key resident Paul Glosser isn't letting his 85th birthday slow him down.


text:
Break the Limits!
You are trapped in a room and the only thing you can do is think.
4.15 / 5.00 38,749 ViewsCap'n Marcela
Can you help Cap'n Marcela save her village from Evil Puffy shirt Morgan?
3.93 / 5.00 6,308 ViewsOriginally featured on Newgrounds in 1999, I still get a kick out of this one. It was the second episode of Pico, obviously much cooler than Darnell's episode but not as infamous as Pico's School, which soon followed.
My friend Sean provided the voice of Nene when she jumps out the window. The rest is all me... yay! Also note the cute Club a Seal reference (newgrounds.com/seals).
Why would she have milk in her room if she is lactose and tolerant... not mentioning her head blowing up xD
Not rating it too low because the little of what it is is somewhat entertaining. :)
when u kill her,or it, it says back to main menu. there is no main menu.
i'm nine and bad as crap! and the only thing that brought me here was the entertainment of nene killing herself but Newgrounds is still awesome. GO NEWGROUNDS! . WHOO!!!!!!!


text:
Edit Symbol List
Enter up to 25 symbols separated by commas or spaces in the text box below. These symbols will be available during your session for use on applicable pages.
Don't know the stock symbol? Use the
Symbol Lookup tool.
Alphabetize the sort order of my symbols
Investing just got easier…Sign up now to become a NASDAQ.com member and begin receiving instant notifications when key events occur that affect the stocks you follow.Access Now X |
News for CVR
Chicago Rivet & Machine Co.: A Debt-Free Cash Cow On Sale?
1/28/2015 2:02:00 PM - Seeking Alpha -
Deckers Is A Long-Term Value Stock - Cramer's Lightning Round (1/21/15)
1/22/2015 7:33:00 AM - Seeking Alpha -
Safeway Up on Sale of Property Development Centers' Assets - Analyst Blog
12/26/2014 5:30:00 PM - Zacks.com -
Chicago Rivet & Machine Co. (CVR) Ex-Dividend Date Scheduled for December 03, 2014
12/2/2014 9:00:01 AM - NASDAQ.com News -
Chicago Rivet & Machine Co. Declares Dividend
11/17/2014 11:40:00 AM - PR Newswire


text:
Four NSSA Teams, (U10 Maroon Boys, U13 C1 Girls, U13 C2 Boys and U14 C2 Boys) received an OATHS Award for Fall 2014. Referees at every game evaluate players, coaches and ans are evaluated for their positive and respectful support of players, coaches and referees. Responses are tabulated and data analyzed to determine winners. Only one team from each level and gender is selected. Congratulations to our NSSA Teams for their hard work and respect for the game.
The NSSA U13C2 Boys received the award for the Fall 2014 season. Only ONE team from each level and gender is chosen each season. The OATHS evaluation box is included on every Match Report and referees are asked to rate players, coaches and spectators. Data is tabulated and analyzed to determine each seasons' winners. Congratulations to the team, teh coaches and their famns for representing the best of NSSA through their respectful and encouraging attitude.
NSSA has launched a new store through Planet Soccer for all of your club gear. You will find hoodies, t-shirts, caps, hats, blankets, backpacks and more. Click to visit store.
NSSA U10 Girls Maroon Stingrays have stellar Fall season!
This Fall (2014) the Stingrays faced the top academy soccer teams in Minnesota for their age group at the Fall Cup and the Woodbury Fall Classic. Going undefeated in all of those matches proves that hard work during training does pay off during matches. The team has an agreement in place in which they train during practice the way they play in a match, which is with high intensity. This group of girls have worked hard over the past several years and continue to grow together. Even though we don't focus on win / loss at the U9 / U10 levels it is hard not to notice as these girls certainly like to compete." The Stingrays are coached by Sean Stinnett.
The NSSA U12 C1 Girls had a successful tournament season with a Championship finish at the Lake Superior Open in Duluth and 2nd place finish at USA Cup. The girls prevailed in Duluth after rain delays and muddy fields. At USA Cup, the girls lost 2-1 to Winnipeg in the final 2 minutes of an exciting, defensive battle. The Blue Crew was coached this summer by Karin Meloch, John Reinart and Grace Hanson.
The NSSA Girls U12 C3 Team brought home first place at the St. Croix Cup in Lakeland, MN, May 30 - June 1. The girls worked hard through rainy conditions to take home the gold after adrenaline filled wins against St. Croix 5-2 and East Ridge (C2) 2-1. The championship game was rained out and our girls were awarded first place due to points. Great job ladies.
Congratulations to our NSSA U17 Premier ladies on their 2014 MYSA State Cup victory! For the second year in a row, they faced Shattuck St. Mary in the finals and came away with a 2-0 victory after advancing against St. Croix (2-0) and Tonka United (4-3) in the elimination rounds. The team traveled to Ohio to represent Minnesota in the Midwest Regional Championships June 2014. Yay NSSA Blast!
NSSA promotes youth soccer throughout the Roseville Area and Mounds View public school districts in the north metro area of the Twin Cities of Saint Paul and Minneapolis, Minnesota. We are volunteers serving approximately 1800 youth through organized In-House recreational soccer leagues for ages 7 through 18 and Traveling teams for ages 9 through 18. We welcome you to our Club!
A reminder that uniforms must be ordered by January 30. Click on Uniforms & Gear to the left for complete information.
Help your player gain an edge before heading outdoors this spring. Take advantage of NSSA's extra skills training! STARTING FEBRUARY 4: New 8-week course geared to our recreational and novice-select athletes. Our objective is to provide a developmental environment that enhances your player's ability to be comfortable on the ball, make quicker decisions and better understand movements off the ball. Sessions run Wednesdays starting Feb. 4 and ending March 25 at the Vadnais Sports Dome. Cost is $120.
Each player will take part in a progressive skills program that will work on all facets of the game. Our professional coaches work from a weekly curriculum that will focus on individual skill development, game play in small groups, and general game understanding. Space is limited to 20 players per course.
Footskills Session I: 7-8 pm: U8-U10 Boys & GIrls Footskills Session II: 8-9 pm: U11 - U17 Boys & GIrls
Complete Information (PDF Download) / CLICK HERE TO REGISTER NOW
It's cold outside now but summer is coming…
NSSA offers one of the top recreational programs in the metro area for ages U7 to U18. We offer a budget-saving, early bird registration fee until January 31, 2015. Registration will close February 21. After that date late registrations will only be accepted if space is available.
Please visit the Recreational Page for important details about fees, league dates and much more! Download and share this Flyer with friends and neighbors.
Pro Connect Soccer Center is offering 3v3 Intelligence Team Training for U9 through U12 teams and individuals. Located near Lexington and 694. Players receive technical instruction as well as game play. Session runs Feb. 28 - April 18. For more information contact Brad Fewell, 612-205-1091 or firstname.lastname@example.com
Pro Connect Flyer and Registration Form (PDF Download)
Referee training will be held in our area the following dates:
More details coming soon. For further information, click here.
NSSA club gear can be purchased through Planet Soccer including t-shirts, hoodies, fleece, backpacks, blankets, hats and caps, warmups and much more! Click to visit the store today!
Tuesday, July 21 – Thursday, July 23
Day 1
Day 2
Sunday, July 26
Wednesday, July 29
Tuesday, July 28
Monday, July 27
Rain Days
Thursday, July 30
Saturday, August 1
TRYOUT RESCHEDULES DUE TO WEATHER: the event of try-outs being cancelled due to weather, any age groups could be scheduled any time of day on these days: Rain Day 1: Thursday, July 30 / Rain day 2: Saturday, August 1 *Subject to change pending MYSA finalized calendar


text:
Best Players On Mario Kart
Don't agree with the list? Vote for an existing item you think should be ranked higher or if you are a logged in, add a new item for others to vote on or create your own version of this list.The Top Ten
Always play him he is very good and he is also really fun to drive :) (Yoshi)
4Bowser Jr.
5Diddy Kong
6Koopa Troopa
8Dry Bones
Every time I'm Dry Bone, I always win Dry Bones is really fast.
10King Boo
King Boo is beast. He is very underrated which sucks. Boo is misunderstood. So he tried to kill Luigi and Mario but that was because he's lonely! Boo has a great heart and lots of love.
Related Lists
Get CodeAdd This List to Your Site
The Contenders
11Donkey Kong
13Baby Mario
14Baby Peach
15Baby Luigi
In Mario Kart DS, he is one of the fastest racers. Do I really need to say anything other than that?
18Funky Kong
Comments About This List
Featured Lists
Popular Lists
New Lists
- Top Ten New Year's Resolutions for 2015
- Best Movies of 2014
- [NEW]Top Ten Home Mortgage Lenders
- Best Car Insurance Companies
- Best Credit Repair Companies
- Best Home Workout Programs
- Best Alternatives to YouTube
- Best Web Hosting Companies
Top Remixes of This List
Posts About This List
List Info
This list was created 3 years, 136 days ago and has been voted on over 0 times. This top ten list has been remixed 2 times.
Updated Wednesday, December 24, 2014
Updated Wednesday, December 24, 2014
List Error Reporting
See an item on this list that's misspelled, duplicated, or doesn't belong? Let us know. Click here to report the error.


text:
How to strategize your social media plan to get the most out of your social media marketing efforts. from the used car sales process
Archive for the 'social media' Category
So how do we move to a more sophisticated Social Marketing approach? Here are five ways you can develop your social strategies from shouty to sophisticated…
As a professional content marketer, you should place high value on beliefs that will make you successful in your business. Find out the beliefs of highly successful content marketer here.
Online market research is key when developing your small business branding. Here are some helpful tips to help you make the most of it.
Social media is finding increasing use in marketing these days. And it is opening up new horizons for both – social media platforms as well as the travel industry.
Over the last few years, a number of social media websites has experimented with their appearances to improve their performance. The latest in the list is Twitter. And the changes it has made are quite significant.
Dealing with a reputation attack is never easy, particularly for small business owners. These are my top 4 tips that could help.
This March I attended Social Media Marketing World in San Diego and while I was there I met Alex Houg, the twenty year old CEO of BlitzMetrics. I have been watching Alex's journey from afar over the past number of months and wondered, what could this young CEO teach me about Facebook marketing?
Growth hacking can be a term that sounds like the latest marketing buzz word, or even a replacement for marketing itself. It can be argued that ask three people what it means, and they will give you two different definitions each
You're an accountant and wondering why you should be on Twitter. What is all this you hear about tweeting, retweeting, hashtags and mentions?


text:
| |
COMMERCIAL DESCRIPTION Like Freigeist Abraxas, its also inspired by the style Lichtenhainer, but this version is stronger (6% alc.) and contains more lactic sourness. Brewed until 2012 at Braustelle (375 ml bottle), from 2013 at Göller in Zeil (330 ml bottle).
We Want To Hear From YouJoin us! RateBeer is made by beer enthusiasts for the craft beer community. Your basic membership is free and allows you to read all beer ratings. Click here to create your account... and give your opinion! Join Us » Page 1 2 3 4 5 » 32 |
More Grodziskie/Gose/Lichtenhainers By Style
Anderson Valley Highway 128 Blood Orange Gose 91 Sante Adairius There She Gose 62 Bayerischer Bahnhof Original Leipziger Gose 76 Birrificio del Ducato Kiss Me Lipsia 96 Bayerischer Bahnhof Goseator - Tequila Barrel 70 De Garde Hose 99 Rapp Lichtenheiner 91 Original Ritterguts Gose 95 |
about us About RateBeer FAQ Contact/Feedback New Beers |
add Advanced Search Add A Beer Add A Brewer Add A Place Events |
membership Log In Edit Personal Info Buy Premium Membership Your Messages |
the best RateBeer Best 100 Beer Club The Top 50 |


text:
Ah ha! It's the old shoe-on-the-other-foot thing here. King Koopa is getting a taste of his own medicine from Princess Peach. While waiting for Mario, who is still on World 1-4 instead of here at 8-4, Koopa got tired and fell asleep. Peach found this a golden opportunity to wrap duct tape around his snout, his feet, and chain his arms and feet together. When he woke up, Bowser realized he couldn't move. Worst yet, the roles of capture and prisoner had been reversed and the Princess was holding him hostage. Serves him right.
shizuruminamino (Fan Art Portfolio) Princess Peach Kidnaps Bowser
Promote This Work!
We now require registration to download high resolution fan art. Please take a few seconds to register absolutely free! Click here now. (Registering will also let you tell this artist how much you enjoy their work in the comments below.)
- Created
- 03/18/12
- Category
- Mario Fan Art
- Tags
- Bowser, kidnap, King Koopa, Mario, Princess Peach
- Views
- 2,845 views
- Votes
- 4 votes
- Favorited
- 1 member
- Member Dedication
- Everyone
- Feedback
- 1 comment
- Sourced By
- Available to use (but no submissions yet)!
You're allowed to use this piece for your wallpapers and ecards if you: (1) paste this page's URL when you submit them and (2) agree not to upload your new work outside theOtaku.com - Options
Share this
Sponsor Links
Anime-Posters.com - A great place to buy anime posters. More posters added every week.


text:
We returned today from a fantastic 3 night stay at Hotel Corallo and have to say how much we loved it. On arrival we were offered a room upgrade and shown around the hotel. We were then given a welcome drink and our bags taken to our room. The service throughout our stay continued in this way. We loved the view, the location, the beach below and enjoyed dinner in the restaurant on 2 evenings. Overall a great hotel at a reasonable price. We are already planning a return trip!
- Official Description (provided by the hotel):
- Hotel Corallo is situated on the cliff above the sea, to the end of the coast of Sant'Agnello, full of Orange and Lemons trees, on the top of Marina of Sant Agnello, at few minutes walking from the centre, with on front the whole Neapolitan bay.The main Sorrento square "Piazza Tasso" is at few minutes, or by taxi but it is pleasant a lovely walk. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Hotels.com, Orbitz, Priceline, HotelTravel.com, Agoda, Travelocity, TripOnline SA, Odigeo, Escapio and Tingo so you can book your Hotel Corallo Sorrento reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Corallo Hotel Sant Agnello
- Hotel Corallo Sorrento Italy/Province Of Naples


text:
Horn of Africa food crisis
In the summer 2011, East Africa's worst drought in 60 years put more than 12 million at risk of starvation. Failed crops and dead pastures forced millions to leave their homes in search of food.
To date Mercy Corps teams in Ethiopia, Kenya and Somalia have helped nearly 2 million people caught in the grip of the crisis, saving lives with emergency food, clean water and cash to buy food and essential supplies.
We also created temporary jobs repairing water storage points and clearing roads; run mobile medical clinics to reach those with no alternative; kept livestock healthy with vaccines; and helped to keep families in their own homes, so they don't have to leave everything for life in tent camps.
Now, we continue to support people building resilience to future cycles of drought and hunger — finding new ways to earn money and support their families, strengthening markets to make food more accessible and affordable, training health workers to teach treat disease and promote healthy nutrition, replacing lost livestock and improving the health of their animals, cultivating drought-resistant crops and better managing their land and water supplies.
All stories about Horn of Africa food crisis
Kenya: Stranded and struggling eight miles from water August 11, 2011
These are the children of Qaraa. Covered in dust, thin and dazed, they are on the brink.
Somalia: A family torn to pieces August 11, 2011
Disasters take so many things from people; health, prosperity and hope can all fall victim. But no one can know what life has in store for them, and all we can do is carry on — just as women like Nadifo, who has struggled with some of the worst possible circumstances, has had to do.
Somalia: Testifying before the U.S. Senate about the Horn of Africa crisis August 10, 2011
Kenya: Helping little Fatima collect water for her family August 9, 2011
When I asked Fatima how old she was, she paused and looked away. Then she looked up, said ten and grinned. I got the distinct impression she'd picked a number at random.
Ethiopia: Helping ensure that Ethiopian herders don't lose everything August 7, 2011
Ethiopia: Dried-up lake in Gashamo district, Ethiopia August 6, 2011
This was a small lake that served the water needs of families and their livestock — now it's mostly dried up.
Ethiopia: 'I have not known it this bad in 30 years' August 6, 2011
Earlier this week in Ethiopia's drought-hit Somali Region, I saw a small boy kneel and drink from what was left of a pond.
Ethiopia: Feeding hungry children in remote Ethiopia August 4, 2011
Hibo — a tiny, chubby-cheeked three year old — seemed to take great delight in looking everywhere except my camera as I tried to take her photo. From her mother's hip she giggled, turned away and pulled faces by turns, to the amusement of all around.
Kenya: Providing clean water to 16 drought-affected Kenyan villages August 3, 2011
Ethiopia, Somalia, Sudan: Horror in the Horn of Africa: reflections and projections August 2, 2011
I first encountered extreme poverty and hunger in 1972 when I drove through Uganda, Kenya, Tanzania and Zambia on a church mission trip. It struck me in the heart and I felt helpless.


text:
Article ID: 960411 - View products that this article applies to. This article has been archived. It is offered "as is" and will no longer be updated. This article has been archived. It is offered "as is" and will no longer be updated. On This PageSymptomsWhen you install a Microsoft SQL Server 2008 service pack or hotfix that tries to update a custom resource DLL, the CLUSCTL_RESOURCE_UPGRADE_DLL control code fails with an "access denied" error message. Therefore, you cannot install the service pack or the hotfix. Additionally, you see an event that is similar to the following in the cluster log: 0000068c.00001370::date & time ERR [RCM] rcm::RcmResControl::DoResourceControl: ERROR_ACCESS_DENIED(5)' because of 'MoveFileEx( currentDllPath.c_str(), oldFileName.c_str(), MOVEFILE_REPLACE_EXISTING | MOVEFILE_COPY_ALLOWED | MOVEFILE_WRITE_THROUGH )' This problem occurs if the following conditions are true:
CauseThe Windows ClusterResourceControl API is used to update resource type DLLs in a Windows Server 2008 Failover Cluster environment. This API causes the computer to require a restart each time a resource DLL is updated, even if it is not necessary. If the computer is not restarted, the access denied error occurs. ResolutionA hotfix is available to resolve this problem. This hotfix resolves the problem for all products that use resource control to update a custom resource DLL. Hotfix informationA supported hotfix is available from Microsoft. However, this hotfix is intended to correct only the problem that is described in this article. Apply this hotfix only to systems that are experiencing this specific problem. This hotfix might receive additional testing. Therefore, if you are not severely affected by this problem, we recommend that you wait for the next software update that contains this hotfix.If the hotfix is available for download, there is a "Hotfix download available" section at the top of this Knowledge Base article. If this section does not appear, contact Microsoft Customer Service and Support to obtain the hotfix. Note If additional issues occur or if any troubleshooting is required, you might have to create a separate service request. The usual support costs will apply to additional support questions and issues that do not qualify for this specific hotfix. For a complete list of Microsoft Customer Service and Support telephone numbers or to create a separate service request, visit the following Microsoft Web site: http://support.microsoft.com/contactus/?ws=support Note The "Hotfix download available" form displays the languages for which the hotfix is available. If you do not see your language, it is because a hotfix is not available for that language.
Important Windows Vista and Windows Server 2008 hotfixes are included in the same packages. However, only one of these products may be listed on the "Hotfix Request" page. To request the hotfix package that applies to both Windows Vista and Windows Server 2008, just select the product that is listed on the page. PrerequisitesTo apply this hotfix, you must have the Enterprise edition or the Datacenter edition of Windows Server 2008 installed on the computer.Restart requirementYou have to restart the computer after you apply this hotfix.Hotfix replacement informationThis hotfix does not replace any other previously released hotfixes.Registry informationTo use this hotfix, you do not have to change the registry.File informationThe English version of this hotfix has the file attributes (or later file attributes) that are listed in the following table. The dates and times for these files are listed in Coordinated Universal Time (UTC). When you view the file information, it is converted to local time. To find the difference between UTC and local time, use the Time Zone tab in the Date and Time item in Control Panel.Windows Server 2008 noteThe .manifest files and the .mum files that are installed in each environment are listed separately in the "Additional file information for Windows Server 2008 and for Windows Vista" section. These files and their associated .cat (security catalog) files are critical to maintaining the state of the updated component. The .cat files are signed with a Microsoft digital signature. The attributes of these security files are not listed.For all supported x86-based versions of Windows Server 2008Collapse this table
For all supported x64-based versions of Windows Server 2008Collapse this table
For all supported Itanium-based versions of Windows Server 2008Collapse this table
WorkaroundTo work around the issue, you can restart each node of the cluster after each update to custom resource DLLs. StatusMicrosoft has confirmed that this is a problem in the Microsoft products that are listed in the "Applies to" section. More informationAdditional file information for Windows Server 2008Additional files for all supported x86-based versions of Windows Server 2008Collapse this table
Additional files for all supported x64-based versions of Windows Server 2008Collapse this table
Additional files for all supported Itanium-based versions of Windows Server 2008Collapse this table
http://msdn.microsoft.com/e n-us/library/aa367688(VS.85).aspx For more information about custom resource types, visit the following MSDN Web site:
For additional information, click the following article number to view the article in the Microsoft Knowledge Base:
Description of the standard terminology that is used to describe Microsoft software updatesPropertiesArticle ID: 960411 - Last Review: January 15, 2015 - Revision: 3.0 Applies to


text:
Publications (76)332.76 Total impact
- Leukemia Research 05/2013; 37:S113. · 2.69 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: A subset of myeloproliferative disorders (MPN) and myelodyplastic syndromes (MDS) evolves to fibrosis of the bone marrow associated with haematopoietic insufficiency. We have been interested in chemokines involved in fibrogenesis within the bone marrow. Besides TGFβ we could identify a number of additional mediators including osteoprotegerin and bone morphogenic proteins. In MPN JAK2 or MPL mutation are not linked to the propensity for bone marrow fibrosis. The hypothesis that an increased intramedullary decay of megakaryocytes undergoing appotosis takes place within the marrow, thus liberating fibrogenic cytokines, could not be confirmed. On the contrary, megakaryocytes in primary fibrosis revealed low expression of proapoptotic genes such as BNIP3. Interestingly, BNIP 3 expression was down regulated in megakaryocytic cell lines kept in hypoxic conditions. Furthermore, expression arrays revealed hypoxia inducible genes to be up-regulated in primary myelofibrosis. Fibrotic MPN are characterized by aberrant proplatelet formation which represent cytoplasmic pseudopodia and normally extend into the sinus. In fibrotic MPN orientation of proplatelet growth appears to be disturbed, which could lead to an aberrant deposition of platelets in the marrow with consecutive liberation of fibrogenic cytokines.Fibrogenesis & Tissue Repair 06/2012; 5 Suppl 1:S21. -
Conference Paper: Longitudinal Molecular Profiling In Human Allografts
American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado; 05/2011 - [Show abstract] [Hide abstract]
ABSTRACT: After publication of our article 1, we realized the need for posting a correction note in order to prevent i) overinterpretation of some results by the readers and ii) concerns about potentially unintended misguidance by the authors.Journal of Translational Medicine 03/2011; 9:24. · 3.99 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n = 7) and chronic myelomonocytic leukaemia (CMML, n = 8) and were compared to BCR-ABL-positive chronic myelogenous leukaemia (CML, n = 10) and non-neoplastic haematopoiesis (n = 10). Down-regulation of miR-10a was found in CMML but also in CML (each p < 0.05, versus controls). Overexpression of miR-424 was detected in aCML (p < 0.05, versus CML and controls). Despite different compositions of bone marrow cells, expression of myelopoiesis-associated microRNA shows mainly similar patterns in aCML and its main differential diagnosis CMML and does not allow discrimination of these two MDS/MPN entities. Therefore, the link of deregulated microRNA expression to disease-related phenotype and the underlying molecular mechanism are still unknown.Annals of Hematology 03/2011; 90(3):307-13. · 2.40 Impact Factor - Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 03/2011; 25(6):1050-3. · 10.16 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm showing aberrant bone marrow remodeling with increased angiogenesis, progressive matrix accumulation, and fibrosis development. Thrombospondins (TSP) are factors sharing pro-fibrotic and anti-angiogenic properties, and have not been addressed in PMF before. We investigated the expression of TSP-1 and TSP-2 in PMF related to the stage of myelofibrosis (n = 51) and in individual follow-up biopsies by real-time PCR, immunohistochemistry, and confocal laser scanning microscopy (CLSM). TSP-1 was significantly overexpressed (p < 0.05) in all stages of PMF when compared to controls. Individual follow-up biopsies showed involvement of TSP-1 during progressive myelofibrosis. TSP-2 was barely detectable but 40% of cases with advanced myelofibrosis showed a strong expression. Megakaryocytes and interstitial proplatelet formations were shown to be the relevant source for TSP-1 in PMF. Stroma cells like endothelial cells and fibroblasts showed no TSP-1 labeling when double-immunofluorescence staining and CLSM were applied. Based on its dual function, TSP-1 in PMF is likely to be a mediator within a pro-fibrotic environment which discriminates from ET cases. On the other hand, TSP-1 is a factor acting (ineffectively) against exaggerated angiogenesis. Both features suggest TSP-1 to be a biomarker for monitoring a PMF-targeted therapy.Annals of Hematology 01/2011; 90(1):33-40. · 2.40 Impact Factor - Blood 12/2010; 116(23):5073-4. · 9.78 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Proplatelets represent pseudopodia of megakaryocytes which extend into bone marrow sinuses to release platelets. Proplatelets were visualized by immunohistochemical and confocal microscopy. In trephines from essential thrombocythaemia (ET, n=10), fibrotic (n=10) and pre-fibrotic (n=10) primary myelofibrosis (PMF) there was a significant increase of proplatelet density compared with normal bone marrow samples (n=10; p<0.001). Manifest fibrosis exhibited the highest density and volume ratio with significant differences to non-fibrotic PMF (p<0.001) and ET (p<0.001). This study demonstrates that besides megakaryocytic proliferation extensive pseudopodial proplatelet formation provides a hallmark of MPN. Fibrosing differ from non-fibrosing MPN by density and size of aberrant proplatelets.Leukemia research 11/2010; 34(11):1424-9. · 2.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Monitoring of minimal residual disease (MRD) after allogeneic (allo)-SCT for myelofibrosis (MF) allows recognizing the depth of remission and thus guides application of appropriate therapeutic interventions. MPL W515L/K mutations, which are detected in 5-10% of JAK2V617F-negative patients, may be useful for this purpose. Using a highly sensitive quantitative PCR method, we tested 90 patients with MF who underwent allo-SCT for the presence of MPL W515L/K mutations. Two patients with primary MF were found to harbor MPLW515L while no patient was positive for MPLW515K mutation. Both patients were JAK2V617F negative and cleared the mutation rapidly after allo-SCT and remained negative for a median follow-up of 19 months. The results of molecular monitoring correlated well with other remission parameters such as normalization of peripheral blood counts and morphology and complete donor chimerism. We conclude that MPLW515L can be cleared after allo-SCT and hence may be used as an MRD marker in a proportion of JAK2V617F-negative MF patients.Bone marrow transplantation 09/2010; 45(9):1404-7. · 3.00 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Obliterative airway remodelling is a morphological sequence in a variety of pulmonary diseases. Notably, bronchiolitis obliterans represents one of the key complications of lung transplantation, induced by (immigrating) myofibroblasts. A comparative expression analysis of obliterative airway remodelling in transplanted and non-transplanted patients has not been reported so far. Obliterated and unremodelled airways from explanted lungs (n = 19) from patients suffering from chronic allograft dysfunction, infection, graft-versus-host disease and toxic exposure were isolated by laser-assisted microdissection. Airways from lung allografts harvested shortly before and after transplantation (n = 4) as well as fibroblastic foci from lungs with interstitial pulmonary fibrosis (n = 4) served as references. Pre-amplified cDNA was analysed by quantitative real-time RT-PCR for expression of fibrosis, inflammation and apoptosis-associated genes. Composition of infiltrating cells and protein expression were assessed by conventional histology and immunohistochemistry. Bronchiolitis obliterans in transplanted patients showed a significant increase of BMP-7 expression (p = 0.0141 compared with controls), while TGF-beta1 and FGF-2 as well as BMP-4 and BMP-7 were up-regulated in fibroblastic foci in interstitial pulmonary fibrosis (p < 0.0424 compared with controls). Regarding other fibrosis-associated genes (BMP-6, SMAD-3, CASP-3 and CASP-9, FASLG, NF-KB1, IL-1 and IL-2) as well as cellularity and cellular composition, no significant differences between obliterative airway remodelling in transplanted and non-transplanted patients could be shown. Obliterative airway remodelling in lung allografts and in non-transplanted patients share many morphological and genetic traits. BMPs, especially BMP-7, warrant further investigation as possible markers for the aggravation of airway remodelling.Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 09/2010; 457(3):369-80. · 2.56 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n=12) and distinct cytogenetic aberrations (n=12). In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), -7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS. These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells.Leukemia research 09/2010; 34(9):1169-74. · 2.36 Impact Factor - American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans; 05/2010
- [Show abstract] [Hide abstract]
ABSTRACT: In damaged organs tissue repair and replacement of cells by connective tissue provokes a response of fibroblasts to cellular stress factors such as hypoxia.MicroRNAs (miRNA) are small non-coding RNA molecules which bind to their mRNA targets which eventually lead to repression of translation. Whether the response of fibroblasts to stress factors also involves the miRNA system is largely unknown. By miRNA profiling we identified down-regulation of miRNA-449a/b expression in hypoxic fibroblasts. Specific miRNA inhibitors and mimics showed direct evidence for targeting the serine protease inhibitor (serpin) protein (SERPINE1; plasminogen activator inhibitor-1, PAI-1) by miRNA-449a/b leading to SERPINE1 mRNA and protein up- and down-regulation, respectively. SERPINE1 expression in vivo could be located predominantly in areas of fibrosis and remodeling. Our study offers serious lines of evidence for a novel hypoxia-dependent mechanism involving hypoxia-induced decrease of clustered miRNA-449a/b, hypoxia-induced amplification of concomitant increase of targeted SERPINE1 (PAI-1) and its overexpression in tissues showing a hypoxic environment.Journal of Translational Medicine 04/2010; 8:33. · 3.99 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: In primary myelofibrosis (PMF) and essential thrombocythemia (ET) the megakaryocytic lineage characteristically shows aberrant proliferation and maturation in which the regulatory microRNA (miR) system might be involved. Laser-microdissected PMF and ET megakaryocytes were analysed with real-time polymerase chain reaction (PCR) low density arrays comprising 365 microRNAs. The highest megakaryocytic expression levels were observed for miR-223, which is known to be expressed also in granulopoiesis. Cluster analysis revealed a tendency of disease-specific megakaryocytic microRNA expression profiles indicating that a complex shift of microRNA expression appears to be the underlying defect. Increased accumulation of miR-146b was observed in cellular stage PMF (p = 0.0125) but not ET megakaryopoiesis. In conclusion, this is the first microRNA profiling of in situ-derived PMF, ET and normal megakaryocytes.Platelets 09/2009; 20(6):391-400. · 2.63 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We investigated whether, in myelodysplastic syndromes (MDS), aberrant expression of miR-150/miR-221/miR-222 and their designated target mRNA molecules MYB, p27 and c-KIT may be involved in insufficient haematopoiesis. In a series of MDS (n=52), an aberrant increase of miR-150 was found only in MDS with associated del(5q) (n=9; p<0.01). The mRNA expression of transcription factor MYB, the designated target of miR-150, was shown to correlate inversely with the miR-150 level. Acute leukaemia evolving from MDS (n=11) showed significantly decreased levels of miR-221 but not miR-222. We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q).Leukemia research 08/2009; 34(3):328-34. · 2.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Among Philadelphia chromosome-negative myeloproliferative neoplasms (Ph(-) MPN), essential thrombocythemia (ET) and the prefibrotic phase of primary myelofibrosis (PMF) represent two subtypes with considerable overlap. In this study, histopathological classification of 490 MPN cases was correlated with the allelic burden of JAK2(V617F) and MPL(W515L). Ph(-) MPN entities largely overlap with regard to JAK2(V617F) and MPL(W515L) allele burden, but ET displayed mutant allele burden <50%. PMF with different stages of myelofibrosis all yielded similar JAK2(V617F) allele burden. At initial presentation one-quarter of prefibrotic PMF cases exhibited an allele burden exceeding 50% (38% median JAK2(V617F) alleles, n=102). In ET, its main differential diagnosis, not a single case was found with >40% JAK2(V617F) alleles (median, 24% JAK2(V617F) alleles; n=90; p<0.001). Increase in JAK2(V617F) alleles during follow-up could not be linked to fibrosis or blastic progression but was related to polycythemic transformation in ET. MPL(W515L) was found in 3% of ET and 8% of PMF, with a significantly higher percentage of mutated alleles in fibrotic than prefibrotic PMF (median, 78% MPL(W515L) alleles; p<0.05). Histopathological categories ET and prefibrotic PMF correlate with significant differences in mutant allelic burden of JAK2(V617F), but not of MPL(W515L) which, by contrast to JAK2(V617F), shows a higher percentage of mutated alleles in fibrotic than in prefibrotic cases. Thus, for Ph(-) MPN in which ET and prefibrotic PMF represent the most probable diagnoses, a JAK2(V617F) allele burden >50% favors a diagnosis of prefibrotic PMF.Experimental hematology 08/2009; 37(10):1186-1193.e7. · 3.11 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by remodelling of the bone marrow, including progressive myelofibrosis and exaggerated angiogenesis. Advanced PMF frequently shows a full-blown fibre meshwork, which avoids aspiration of cells, and the expression profile of genes related to stroma pathology at this stage remains largely undetermined. We investigated bone marrow core biopsies in PMF showing various degrees of myelofibrosis by custom-made low density arrays (LDA) representing target genes with designated roles in synthesis of extracellular matrix, matrix remodelling, cellular adhesion and motility. Among a set of 11 genes up-regulated in advanced stages of PMF (P < or = 0.01) three candidates, PTK2 protein tyrosine kinase 2 (PTK2), transforming growth factor beta type II receptor (TGFBR2) and motility-related protein-1 (CD9 molecule, CD9), were investigated in more detail. PTK2, TGFBR2 and CD9 were significantly overexpressed in larger series of advanced PMF stages (P < or = 0.01 respectively). Endothelial cells of the increased microvessel network in PMF could be identified as a predominant source for PTK2, TGFBR2 and CD9. CD9 also strongly identified activated fibroblasts in advanced myelofibrosis. We conclude that PTK2, TGFBR2 and CD9 represent new target molecules involved in bone marrow remodelling of PMF and warrant further investigation for potential targeted therapy.British Journal of Haematology 07/2009; 146(5):510-20. · 4.94 Impact Factor - British Journal of Haematology 04/2009; 145(5):673-5. · 4.94 Impact Factor
Article: Opposite expression pattern of Src kinase Lyn in acute and chronic haematological malignancies.
[Show abstract] [Hide abstract]
ABSTRACT: Lck/yes-related novel (Lyn) tyrosine kinase overexpression has been suggested to be important for leukaemic cell growth making it an attractive target for therapy. By contrast, Lyn deficiency was shown to be responsible for a phenotype resembling myeloproliferative neoplasm (MPN) in mice. We aimed to shed more light on Lyn's role in haematological neoplasm and systematically investigated Lyn expression in MPN, acute and chronic leukaemia subtypes (n = 236). On top, B-cell chronic lymphocytic leukaemia (B-CLL) and chronic myeloid leukaemia significantly overexpressed Lyn when compared to de novo acute lymphoblastic leukaemia, de novo acute myeloid leukaemia (AML) and Philadelphia-chromosome-negative myeloproliferative neoplasms (p < 0.001). Most of acute leukaemia subtypes showed a notable down-regulation of Lyn mRNA but anyhow individual cases were labelled for the active form of Lyn protein. Intriguingly, secondary AML evolved in myelodysplastic syndromes revealed almost undetectable Lyn. Overexpression of Lyn in B-CLL was associated with a significant down-regulation of microRNA-337-5p suggesting that aberrant expression of this particular microRNA could be involved in post-transcriptional control of Lyn mRNA fate. We conclude that tyrosine kinase Lyn contributes to the malignant phenotype in certain leukaemia subtypes and therefore attracts targeted therapy.Annals of Hematology 03/2009; 88(11):1059-67. · 2.40 Impact Factor
Publication Stats
873 | Citations | |
332.76 | Total Impact Points | |
Top Journals
Hannover Medical School
- Institute for Pathology
Hannover, Lower Saxony, Germany
University of Veterinary Medicine Hannover
Hanover, Lower Saxony, Germany
Hochschule Hannover
Hanover, Lower Saxony, Germany
University of Southampton
Southampton, England, United Kingdom