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Researchers Decide Key Factor in Circadian Clock Velocity |
In a discovery which will result in new remedies for sleep issues, jet lag, and different well being issues tied to circadian rhythms, researchers at Dartmouth's Geisel Faculty of Drugs have recognized a determinant of the circadian clock's interval. Their findings seem within the January 29 concern of Science journal. Whether or not in fungi or human beings, circadian clocks affect almost all points of an organism's life. On a molecular degree on the core of those circadian rhythms, organic oscillators are current and key proteins comprising these cycles have a lifetime of roughly 24 hours. As a result of the interval of the clock matched the lifetime of the proteins it was assumed for a few years that the steadiness of the protein decided the interval size of those organic clocks. Nevertheless it's not that straightforward. Why this turnover happens inside 24 hours has lengthy been attributed to the clock proteins themselves, which bear coordinated and progressive modification-truly phosphorylation, which modifies protein construction and exercise-resulting in degradation and turnover. Primarily, clock proteins are slowly phosphorylated till they develop into unstable and disappear permitting the cycle of synthesis and destruction to start out once more. By analyzing in a well-known mannequin organism the elements resulting in interval willpower-and the longstanding causal loop uniting clock protein phosphorylation with stability-Dartmouth researchers have pinned down the determinant of the clock's interval. "All of us used to assume the circadian cycle ended when the necessary clock protein was degraded and that interval size was decided largely by how secure these proteins have been," says principal investigator Jay Dunlap, PhD, professor of genetics and biochemistry and chair of the Division of Genetics, in a launch. However Dunlap's staff, in work supported by the U.S. Nationwide Institute of Basic Medical Sciences and accomplished in collaboration with the lab of Luis Larrondo from the Pontificia Universidad Católica de Chile, discovered that phosphorylation itself was adequate to vary the effectiveness of the protein within the unfavorable suggestions of the oscillator in order that the clock protein was not efficient in suggestions. Though protein degradation is the ultimate consequence, protein construction, not modifications in stability, may very well be the important thing aspect figuring out clock velocity. "Surprisingly, we discovered that stability just isn't the important thing think about interval willpower," Dunlap says. "As soon as phosphorylation has handed a sure level it doesn't matter whether or not or not the clock protein has degraded as a result of at that time it's invisible to the clock equipment. "The circadian clock influences our day by day lives in additional methods than we will rely," Dunlap says, "and this work factors to how the clock is perhaps manipulated to enhance well being." |
Led By Home Neurology Enterprise, Natus Sees Report Progress |
"I'm more than happy with our fourth quarter outcomes as we achieved document revenues and earnings. Each our neurodiagnostic and new child care companies carried out effectively within the quarter led by excellent efficiency in our home neurology enterprise," says Jim Hawkins, Natus Medical president and CEO, in a launch. "Our non-GAAP fourth quarter gross margin of sixty two.9% and our non-GAAP full yr working margin of sixteen.1% for 2014 had been most satisfying as bettering margins had been a serious objective for Natus in 2014. We search for continued margin enchancment in 2015." For the fourth quarter ended December 31, 2014, Natus reported income of $ninety four.zero million, a rise of four% in comparison with $ninety.6 million reported for the fourth quarter 2013. For the complete yr ended December 31, 2014, the corporate reported income of $355.eight million, a rise of three% in comparison with $344.1 million reported for 2013. Money and money equivalents elevated by $eight.9 million to $sixty six.7 million throughout the quarter. Complete debt was lowered by $eight.zero million, as the corporate repaid in full its long run debt. Natus additionally repurchased $1.2 million of firm inventory throughout the fourth quarter. "Our latest acquisitions of NicView and World Neuro-Diagnostics (GND) together with the continued growth of our Peloton listening to screening service enterprise are increasing our served markets and driving development as we enter 2015," Hawkins says. "NicView expands our providing with an progressive resolution for streaming video to households with NICU infants, from any gadget-from wherever on the earth. GND brings Natus the management place in neurodiagnostic video EEG testing providers that may be carried out on the affected person's residence, hospital, or doctor's workplace. These new choices are the start of an increasing service enterprise and place Natus for accelerating income development and document earnings in 2015." |
At-Residence Sleep Apnea Check Lets You Keep away from Night time in Clinic |
A Newsmax Well being report examines the accuracy and effectivity of at-residence sleep apnea checks. |
Working four You: Lack of Sleep Contributing to Childhood Weight problems |
A Journal of Pediatrics research reveals that lack of sleep is a contributing issue to weight problems in youngsters, as reported by KXLY.com |
Sleep Improves, Buildings Toddler Reminiscence |
Whereas infants sleep they're reprocessing what they've discovered. Working with researchers from the College of Tübingen, scientists from the Max Planck Institute for Human Cognitive and Mind Sciences in Leipzig have found that infants of the age from 9 to sixteen months keep in mind the names of objects higher if that they had a brief nap. And solely after sleeping can they switch discovered names to comparable new objects. The toddler mind thus types common classes throughout sleep, changing expertise into information. The researchers additionally confirmed that the formation of classes is intently associated to a typical rhythmic exercise of the sleeping mind referred to as sleep spindles: Infants with excessive sleep spindle exercise are notably good at generalizing their experiences and creating new information whereas sleeping. The outcomes are revealed in Nature Communications. The stream of data from the sensory organs is essentially reduce off whereas we sleep, however many areas of the mind are particularly lively. Most mind researchers at this time consider that the sleeping mind retrieves current experiences, thereby consolidating new information and integrating it into the prevailing reminiscence by strengthening, re-linking and even dismantling neuronal connections. Which means sleep is indispensable for reminiscence. The Max Planck researchers have discovered this to be the case even in infants and toddlers. To be able to research the influence of sleep on toddler reminiscence, they invited mother and father to attend a research with their 9- to sixteen-month-previous youngsters. In the course of the coaching session, the infants have been repeatedly proven pictures of sure objects whereas listening to the fictional names assigned to the objects. Some objects have been comparable to one another, various solely of their proportions, colours or in sure particulars. The same objects, which belonged to the identical class in line with their shapes, have been all the time given the identical names. Throughout this course of, the researchers recorded the infants' mind exercise utilizing electroencephalography (EEG). One group of infants spent the subsequent one to 2 hours sleeping of their prams whereas an EEG was recorded, whereas the others remained awake, going for a stroll of their prams or enjoying within the examination room. Within the subsequent testing session, the researchers once more introduced the infants with image-phrase pairs-this time each in the identical mixtures as within the studying session and in new mixtures-and once more measured their mind exercise whereas doing so. The evaluation of mind exercise confirmed that the infants had discovered the names of the person objects in the course of the coaching session, regardless of their age. The state of affairs with categorization, nevertheless, was totally different: On the finish of the coaching session, they have been unable to assign new objects to the names of comparable objects which that they had heard a number of occasions. In the course of the subsequent testing session, the mind exercise of the infants who had slept after the coaching session was markedly totally different from that of the group who had stayed awake. Whereas the group who had stayed awake had forgotten the names of the person objects, the youngsters within the sleep group remembered the thing-phrase mappings. There have been additionally radical variations of their talents to categorize the objects. "The infants who slept after the coaching session assigned new objects to the names of comparable-wanting objects," says Manuela Friedrich of the Max Planck Institute for Human Cognitive and Mind Sciences, in a launch. "They weren't in a position to try this earlier than their nap, and nor have been those who stayed awake capable of do it. Because of this the classes should have been shaped throughout sleep." Whereas the youngsters's age had no impact, a specific sort of brainwave referred to as the sleep spindle has a big influence on studying outcomes. Sleep spindles happen when nerve bundles between the thalamus and the cerebral cortex generates rhythmic exercise of 10 to fifteen cycles per second. They're recognized to affect reminiscence consolidation in adults. "The higher an toddler's spindle exercise, the higher it could actually assign class names to new objects after sleep," Friedrich says. These outcomes present that sleep considerably impacts reminiscence group even within the toddler mind-and at a time when reminiscence is rising on an enormous scale. "The waking toddler mind shortly forgets newly discovered names, however throughout sleep, phrases are extra durably linked to things and imprinted," says Angela Friederici, director on the Leipzig-based mostly Max Planck Institute and head of the research. Sleep and sleep spindles additionally allow the toddler mind to pool comparable meanings. Apparently, when the mind is essentially reduce off from outdoors influences, it could actually manage its experiences and type new generalizations. "On this means, sleep bridges the hole between particular objects and basic classes, thus transferring expertise into information," Friederici says. |
Freedom from CPAP Ebook |
A e-book written by a board-licensed ENT and a dentist specializing in sleep apnea remedy is a brand new useful resource for sufferers who're keen on choices aside from CPAP to deal with their sleep apnea. Freedom from Cpap: Sleep Apnea Hurts, the Remedy Doesn't Have To by Dr David G. Dillard and Dr Mayoor Patel offers a uniquely complete overview of sleep apnea from each an ENT and a dental perspective. Dillard, a Navy veteran, is board licensed by the American Board of Otolaryngology, Head and Neck Surgical procedure. He has over a decade of expertise within the remedy of ENT issues and obstructive sleep apnea. He's the patent-pending innovator of a number of units and coverings which might be the results of his a few years expertise in his subject. Dillard held a tutorial appointment at Emory College Faculty of Drugs, at present holds a tutorial appointment on the College of Georgia Faculty of Drugs. Patel has earned a number of fellowships and quadruple board licensed the world of orofacial ache and dental sleep drugs. He presently is an adjunct school member with Georgia Regents College and The Atlanta Faculty of Sleep Drugs. Contributions have been revealed textbook chapters, numerous skilled and shopper articles. He additionally holds patents on oral equipment for sleep apnea and different associated merchandise. The e-book is obtainable from Lulu.com in each e book and paperback variations. |
Entire Well being Dentistry E-book |
Namrita Singh, DMD, the proprietor of Allen Entire Well being Dentistry in Allen, Texas, has written a guide referred to as Entire Well being Dentistry: Why Your Mouth is the Key to Your Physique's Well being. "The issue is that the majority of us see the mouth and its well being as a separate entity from the remainder of the physique. I need to emphasize that though the mouth is an important, delicate organ that requires its personal specialization, it's nonetheless part of the physique," she says within the ebook. With a dental examination by a talented dentist utilizing the present obtainable diagnostic instruments and procedures, reminiscent of oral DNA and scans, sufferers may be screened for sleep apnea, different airway obstructions, numerous inflammatory illnesses, most cancers, TMJ, STD virus, and extra, Singh says, including that the sector of dentistry has come a great distance and now stands beside different medical practices in its significance to illness detection and the entire physique well being of the person. The e-book is obtainable on Amazon.com in each Kindle and paperback variations. Chapter three focuses on sleep apnea. |
Lack of Sleep is Second Most Widespread Explanation for Tardiness Amongst Staff |
In line with a CareerBuilder survey, lack of sleep is the second commonest trigger for tardiness for workers, with 30% of staff citing it. The most typical trigger cited for tardiness is visitors (50%). Rounding out the highest 5 are:
When requested how typically they arrive in late to work, greater than 1 in 5 staff (23%) admitted they do it no less than as soon as a month, and 14% say it's a weekly prevalence for them. Greater than 2,one hundred hiring and human useful resource managers and greater than three,000 staff throughout industries participated within the nationwide survey, carried out on-line by Harris Ballot from November four to December 2, 2014. |
Athlete's Circadian Phenotypes Impression Athletic Competitors Outcomes |
The result of that massive sporting occasion you simply can't wait to observe might rely upon how the timing of the match aligns (or doesn't) with the interior organic clocks of the athletes on the groups, in line with a research reported immediately within the Cell Press journal Present Biology. Athletes and coaches would do properly to make word and regulate their schedules accordingly, the researchers say. The research discovered that the efficiency of competitors-degree athletes varies over the course of the day by as a lot as 26%. Individuals who would naturally choose to sleep in will give their greatest performances hours later within the day than early birds will. "If a 1% distinction in efficiency could make the distinction between 1st place and 4th place in a one hundred meter race and truly win you the gold medal on the Olympics, then think about what a 26% distinction in your efficiency might offer you," says Roland Brandstaetter from the College of Birmingham in the UK, in a launch. "Our analysis takes us away from the thought of 'time of day of the race' and directs us extra to inner organic time." In different phrases, he says, what time is it in your physique clock? Earlier stories had steered that athletes' private greatest performances are all the time within the night. However these research had not truly taken under consideration whether or not these athletes have been "night time owls" or "morning larks." Whereas a person's circadian phenotype typically does shift from childhood into adolescence and maturity, there are actual physiological variations between individuals based mostly on their pure sleep/wake patterns. Brandstaetter and his co-writer Elise Facer-Childs used a novel check to characterize the circadian phenotypes of greater than one hundred twenty athletes. They then chosen 20 athletes representing early, intermediate, and late varieties and examined their cardiovascular endurance in a regular health check at six occasions of day. These health exams revealed appreciable variation in particular person efficiency over the course of the day. The perfect predictor of how properly these teams carried out at a given hour was the time elapsed since their entrained awakening–that's, the time since they might have gotten up within the morning if left to their very own units, alarm clocks switched off. Whereas an early riser could also be at his or her greatest within the early afternoon, somebody who sleeps late hits his or her peak a lot later at night time. The findings "depart little question that the right willpower of an athlete's private greatest efficiency requires consideration of circadian phenotype, efficiency analysis at totally different occasions of day, and evaluation of efficiency as a perform of time since entrained awakening," the researchers conclude. And the findings might come in useful for the remainder of us, too. "Acquiring a private greatest efficiency is on everybody's agenda, however tips on how to do it, now that may be a totally different query," Facer-Childs says. One factor now appears positive: we'd be nicely suggested to shift our consideration from the clock on the wall to the one which's ticking inside every of us. |
Natus Medical Acquires International Neuro-Diagnostics |
Natus Medical Inc has entered the neurodiagnostic providers market via the acquisition of International Neuro-Diagnostics (GND). GND was worthwhile in 2014 with income of roughly $7 million. GND's service provides sufferers a extra handy method to full routine video EEG testing which may be carried out on the residence, hospital, or doctor's workplace. The service additionally supplies complete reporting and help to the doctor. "GND brings video neurodiagnostics to our rising service portfolio," says Jim Hawkins, president and CEO, in a launch. "GND efficiently pioneered this service in Texas and we look ahead to now increasing it to our clients all through america." |
Key aspect in circadian clock velocity found |
In a discovery which will result in new remedies for sleep issues, jet lag and different well being issues tied to circadian rhythms, researchers have recognized a determinant of the circadian clock's interval. |
As much as 2 per cent of Germany's inhabitants depends on hypnotics |
Yearly, the statutory medical insurance corporations cowl payments for some 230 million every day doses of benzodiazepines. |
OTC Sleep Aids with Anticholinergic Results Linked to Elevated Dementia Danger |
A big research hyperlinks a considerably elevated danger for creating dementia, together with Alzheimer's illness, to taking generally used drugs with anticholinergic results at larger doses or for an extended time. Many older individuals take these drugs, which embrace nonprescription diphenhydramine (Benadryl). JAMA Inner Drugs revealed the report, referred to as "Cumulative Use of Robust Anticholinergic Drugs and Incident Dementia." The research used extra rigorous strategies, longer comply with-up (greater than seven years), and higher evaluation of medicine use by way of pharmacy data (together with substantial nonprescription use) to verify this beforehand reported hyperlink. It exhibits a dose response: linking extra danger for creating dementia to greater use of anticholinergic drugs. And additionally it is the primary to recommend that dementia danger linked to anticholinergic drugs might persist-and is probably not reversible even years after individuals cease taking these medicine. "Older adults ought to be conscious that many drugs-together with some obtainable with no prescription, akin to over-the-counter sleep aids-have robust anticholinergic results," says Shelly Grey, PharmD, MS, the primary writer of the report, in a launch. "And they need to inform their well being care suppliers about all their over-the-counter use." The report tracks almost three,500 Group Well being seniors collaborating within the lengthy-operating Grownup Modifications in Thought (ACT), a joint Group Well being-College of Washington (UW) research funded by the Nationwide Institute on Getting older. "However in fact, nobody ought to cease taking any remedy with out consulting their well being care supplier," says Grey, who's a professor, the vice chair of curriculum and instruction, and director of the geriatric pharmacy program on the College of Washington Faculty of Pharmacy. "Well being care suppliers ought to repeatedly evaluate their older sufferers' drug regimens-together with over-the-counter drugs-to search for possibilities to make use of fewer anticholinergic drugs at decrease doses." For example, probably the most generally used drugs within the research have been tricyclic antidepressants like doxepin (Sinequan), first-era antihistamines like chlorpheniramine (Chlor-Trimeton), and antimuscarinics for bladder management like oxybutynin (Ditropan). The research estimated that folks taking a minimum of 10 mg/day of doxepin, four mg/day of chlorpheniramine, or 5 mg/day of oxybutynin for greater than three years can be at higher danger for creating dementia. Grey says substitutes can be found for the primary two: a selective serotonin re-uptake inhibitor (SSRI) like citalopram (Celexa) or fluoxitene (Prozac) for melancholy and a second-era antihistamine like loratadine (Claritin) for allergic reactions. It's more durable to seek out various drugs for urinary incontinence, however some behavioral modifications can scale back this drawback. "If suppliers have to prescribe a medicine with anticholinergic results as a result of it's the greatest remedy for his or her affected person," Grey says, "they need to use the bottom efficient dose, monitor the remedy recurrently to make sure it's working, and cease the remedy if it's ineffective." Anticholinergic results occur as a result of some drugs block the neurotransmitter referred to as acetylcholine within the mind and physique, she says. That may trigger many uncomfortable side effects, together with drowsiness, constipation, retaining urine, and dry mouth and eyes. Some ACT individuals comply with have their brains autopsied after they die. That may make it potential to comply with up this analysis by analyzing whether or not members who took anticholinergic drugs have extra Alzheimer's-associated pathology of their brains in comparison with nonusers. |
Menopause Does Not Create Problem Sleeping |
Ladies of their late 30s and 40s who've hassle sleeping are greater than 3 times extra more likely to endure sleep issues throughout menopause than ladies who've a neater time getting shut-eye, in accordance with a brand new research by researchers from the Perelman Faculty of Drugs on the College of Pennsylvania. Solely 25% of girls who had reported no earlier sleep issues developed average or extreme insomnia or different sleep disturbances throughout a sixteen-yr interval round menopause. What's extra, the researchers say that these sleep woes didn't look like brought on by menopause itself, which can quell widespread fears about signs related to this part of life. The research, revealed within the journal Menopause, is among the many first to doc lengthy-time period sleep patterns in ladies within the years earlier than, throughout, and after menopause. "Sleep issues are a serious problem for ladies approaching mid-life, notably for ladies who've average or extreme sleeping issues earlier than reaching menopause as they're more likely to expertise elevated points all through the transition," says lead writer, Ellen W. Freeman, PhD, analysis professor within the division of Obstetrics and Gynecology on the Perelman Faculty of Drugs on the College of Pennsylvania, in a launch. "A small subgroup of girls with solely delicate sleep disturbance previous to menopause additionally skilled worsening sleep disturbance through the transition, however our outcomes present that for almost all of girls, menopause doesn't additional exacerbate present sleep issues or trigger new ones." The research assessed yearly the sleep patterns of 255 ladies collaborating within the Penn Ovarian Growing older Research who reached pure menopause throughout a sixteen-yr interval (1996-2012). At enrollment, all ladies have been aged 35 to forty eight years and premenopausal, with 28% reporting average-to-extreme sleep disturbances, which is analogous to the prevalence of insomnia signs amongst adults, and fifty six% reporting no sleep disturbances in any respect. Over the sixteen yr interval, eighty two% of the pattern skilled average-to-extreme points with sleep, whereas solely 7% had no poor sleep. The research additionally discovered that scorching flashes are strongly related to poor sleep as anticipated, however a big proportion of poor sleep in menopausal ladies occurred with out scorching flashes. The discovering, Freeman says, signifies that sleep difficulties within the transition to menopause in usually wholesome ladies shouldn't routinely be imputed to ovarian decline. "Our research raises the query of why a big improve in poor sleep ought to floor for a gaggle of girls who skilled solely delicate sleep issues earlier, however not amongst ladies who had average or extreme sleep issues," Freeman says. "That is an space for future research and lots of potential elements ought to be thought-about, akin to hormone fluctuations or modifications, stress, nervousness, relationships, life occasions, and well being issues." Freeman provides that clinicians ought to be alert to the robust risk that poor sleep in ladies approaching menopause shouldn't be merely brought on by menopause or scorching flashes. "Potential causes for poor sleep as an alternative might embrace well being issues, nervousness, and stress," she says, advising that clinicians ought to ask sufferers whether or not they had issues sleeping earlier than midlife in addition to get hold of info on the extent and period of earlier poor sleep patterns to plan the simplest remedies. |
Are Sensible Medicine Driving Silicon Valley? |
Off-label use of "cognitive enhancement" medicine resembling these used to deal with narcolepsy is an actual concern in Silicon Valley, reviews CNN Cash. |
ADHD or Sleep Dysfunction? New Research Suggests Comparable Signs |
A WFLA information report signifies that the American Academy of Pediatrics is alerting mother and father of the variations between ADHD and sleep issues. |
Luna–A Related Sensible Mattress Cowl For A Good Night time's Sleep |
In response to Forbes, Luna is a mattress cowl that may be a sensing system designed to collect knowledge to get an correct image of an individual's sleep. |
Smartphone App Detects Sleep Apnea |
Cellular know-how might fill a niche in medical analysis, reviews The Institute, which particularly studies on SleepAp. |
Jeff Bridges Lulls Listeners to Mattress With New Album 'Sleeping Tapes' |
In line with Rolling Stone, actor Jeff Bridges has launched a 15-track album referred to as Sleeping Tapes designed that will help you doze. |
Insomniacs Might Face Elevated Hypertension Danger |
Insomniacs who take longer than 14 minutes to go to sleep face a higher danger of hypertension, in accordance with new analysis within the American Coronary heart Affiliation journal Hypertension. The research, carried out at West China Hospital, is the primary to check whether or not insomnia with physiological hyperarousal, outlined as an extended time to go to sleep, is linked to hypertension. "We noticed a robust correlation between the diploma of physiological hyperarousal and hypertension," says Xiangdong Tang MD, PhD, co-writer of the research and professor of sleep drugs at West China Hospital, Sichuan College in Chengdu, China. "In different phrases, these insomniacs who have been hyperalert through the day and unable to loosen up and go to sleep through the A number of Latency Sleep Check (MSLT) had the upper danger of hypertension," says research co-writer Alexandros Vgontzas, MD, professor of sleep analysis and remedy within the Division of Psychiatry at Pennsylvania State College School of Drugs in Hershey, Penn. Insomnia is probably the most prevalent sleep problem within the common inhabitants. One-fourth to at least one-third of the overall inhabitants complains of difficuly falling asleep and about 10% have persistent complaints and search medical assist for insomnia. Researchers studied 219 persistent insomniacs and ninety six regular sleepers (common age forty and greater than 60% ladies). They outlined continual insomnia as problem sleeping for greater than six months. The individuals spent one night time monitored in a sleep lab and took the MLST the subsequent day. Monitoring included 4 20-minute nap alternatives at two-hour intervals: 9 AM, eleven AM, 1 PM and three PM. Half the members took 14 minutes or much less to go to sleep and half took greater than 14 minutes to go to sleep. People who took greater than 14 minutes to go to sleep have been thought-about "hyperaroused." Hypertension was based mostly on blood strain measures or a doctor's analysis. Researchers managed for confounding elements akin to weight problems, sleep apnea, diabetes, smoking, alcohol, and caffeine use. Continual insomnia mixed with an MSLT rating larger than 14 minutes elevated the chances of hypertension by 300%. MSLT scores higher than 17 minutes elevated the chances by four hundred%. "Lengthy latency occasions to go to sleep through the day could also be a dependable index of the physiological hyperarousal and organic severity of the dysfunction," Vgontzas says. Historically, insomnia has been perceived as a nighttime sleep problem; nevertheless, a number of research recommend it's a state of 24-hour hyperarousal. A extra biologically extreme sort of insomnia is related to 24-hour hyperarousal and vital cardiometabolic penalties like hypertension. The much less extreme type has primarily psychological roots. Feeling hyperalert or sleepy doesn't permit individuals to perform at their greatest, really feel properly through the day or sleep properly at night time, Vgontzas says. "Though insomniacs complain of fatigue and tiredness in the course of the day, their drawback is that they can't chill out and that they're hyper," he says. "Measures that apply in sleep-disadvantaged regular sleepers—napping, caffeine use, or different stimulants to fight fatigue—don't apply in insomniacs. In truth, extreme caffeine worsens the hyperarousal." Co-authors are Yun Li, MD; Julio Fernandez-Mendoza, PhD; Edward O. Bixler, PhD; Yuanfeng Solar, MD; Junying Zhou, MD; Rong Ren, MD; Tao Li, MD. |
Higher Sleep, Fatigue Options Make A number of Appearances on NTSB's 2015 "Most Needed" Record |
Underneath the broad matter of "require medical health for obligation," the Nationwide Transportation Security Board (NTSB) has recognized obstructive sleep apnea analysis and remedy as on its "most needed listing" of security advocacy priorities for 2015. In its rationalization, the NTSB states: "The aviation medical certification system will be the most strong, however pilots are more and more testing constructive for over-the-counter sedating drugs. Furthermore, though the NTSB has discovered that obstructive sleep apnea has been a think about a number of accidents, all transportation modes nonetheless lack an entire screening course of for this situation….Within the 2013 practice derailment in Bronx, New York, the engineer's sleep apnea was undiagnosed till the week following the derailment, regardless of many visits for occupational and private well being care. With a change in his work patterns, the mixture of the untreated sleep apnea and fatigue from his disrupted sleep schedule led to his fatigue on the time of the accident. Since 2001, the NTSB has recognized obstructive sleep apnea as a think about at the least 9 accidents in 4 transportation modes." To mitigate the danger associated to medical health, the NTSB has made suggestions for a complete medical certification system for security-essential transportation personnel, together with "particular historic questions and bodily examination procedures to determine candidates at excessive danger for sleep issues". Strengthening business trucking security is one other prime precedence for the NTSB in 2015, and it additionally includes the business higher addressing sleepiness and fatigue. The NTSB states: "Regulators have taken preliminary steps by sustaining science-based mostly hours of service guidelines and are within the means of rulemaking mandating digital logging units that may assist guarantee that drivers are adequately rested. Different essential rulemaking initiatives embrace necessities to display drivers for obstructive sleep apnea, different probably impairing medical circumstances, and probably impairing medicine." Within the matter of "implement constructive practice management in 2015," the NTSB additionally mentions the Bronx path derailment, this time stating "The practice's engineer had fallen asleep and did not sluggish the practice from over eighty two miles per hour (mph) to the utmost approved velocity of 30 mph because it entered a curve." The NTSB posits "constructive practice management" (PTC) as a mandated answer will forestall tragedies corresponding to that one. "Constructive Practice Management (PTC) can cease many rail accidents earlier than they occur….Every dying, every damage, and every accident that PTC might have prevented, testifies to the very important significance of implementing PTC now." |
Are Oral Home equipment Efficacious in Sleep Apnea Sufferers Who Drink Alcohol? |
Sheri Katz, DDS, revealed a case research exploring the impression of alcohol ingestion on a affected person with OSA who makes use of oral equipment remedy.Ingesting alcohol previous to sleep in sufferers with obstructive sleep apnea (OSA) exacerbates the severity and frequency of hypoxic occasions and should shorten the time from sleep onset to probably the most extreme occasion. Within the research, "Impact of Beer Ingestion on a Affected person with OSA whereas Utilizing Oral Equipment Remedy," revealed within the Journal of Dental Sleep Drugs, Sheri Katz, DDS, investigated whether or not oral equipment use will shield the affected person from the consequences of alcohol ingestion on respiration. Case Report TopicFor this case report, a sixty three-yr-previous feminine with average OSA (AHI of 15.eight) was fitted for an oral equipment after she stated she stated she couldn't tolerate CPAP with the beneficial full-face masks. The oral evaluation revealed that her tongue degree was excessive, she had a Mallampati III taste bud classification, and her tonsils have been grade 1. No different vital abnormalities have been famous. After making an attempt the equipment, the affected person reported subjective enchancment in her sleep apnea signs. Katz says the affected person reported "feeling refreshed within the morning and was not loud night breathing. With such a constructive report on her subjective signs, she and I have been each excited to validate her enchancment with goal knowledge." Katz gave the affected person an oximeter to make the most of that night whereas she was asleep together with her oral equipment. Case Report OutcomesThe affected person confirmed vital oxyhemoglobin desaturations quickly after retiring for the night time, based on the oximeter. The interval of instability lasted for about 1.5 hours and was not repeated for the rest of the night time. "Once I noticed the report, I used to be disillusioned and puzzled to see that the primary interval of the night time confirmed a big quantity of desaturations however then the outcomes confirmed enchancment for the remainder of the night time," Katz says. "I requested her if she felt she had a mean night time sleep. I confirmed her the outcomes and requested if she had felt unwell or had any congestion or allergic reactions at the start of the night time. That is when she advised me she had been out with buddies and drank two beers." The case report signifies that a subsequent research was carried out with no alcohol 1 month later and no such occasions occurred. Medical Ramifications and Future ResearchThe thought has been proposed that CPAP can offset the hostile results of alcohol on the higher airway, however this case research suggests oral equipment remedy won't be capable of supply the identical safety. The paper signifies that additional analysis is required to verify and probably broaden on this statement. Katz writes, "If oral home equipment are proven to inadequately shield the airway when drunk, sufferers have to be endorsed to this impact; CPAP could also be a greater choice for sufferers that select to make use of alcohol frequently." Katz says, "This is just one case research, however I need to use it as a car to boost questions on whether or not oral home equipment can maintain the airway open when sufferers are drunk. They could not be capable of and we, as clinicians, want to concentrate on this and counsel our sufferers accordingly." Katz provides, "As a result of alcohol consumption is so pervasive in our society and represented in all of our practices, I feel we might study lots from learning sufferers randomized to OAT and CPAP, with alcohol and with out alcohol." Katz says she doesn't have any present plans to pursue any additional analysis on this topic, however believes it might be an exquisite expertise to take part in analysis on this challenge. Cassandra Perez is affiliate editor of Sleep Evaluate. CONTACT firstname.lastname@example.com |
On-line monitoring system for sufferers with sleep apnoea |
The corporate Medco Well being on the Enterprise, Scientific and Technological Park, Espaitec, of the Universitat Jaume I of Castellón, has developed an help system based mostly on telemedicine utilizing... |
Good bedtime habits equal higher sleep for teenagers |
Youngsters acquire higher and extra age-applicable sleep within the presence of family guidelines and common sleep-wake routines, in response to sleep researchers. |
AADSM Launches On-line CE Alternatives in Dental Sleep Drugs |
With extra sufferers being recognized with sleep apnea and oral equipment remedy rising as a key remedy, a background within the administration of sleep-disordered respiration permits medical professionals to offer a lot wanted care to sufferers and develop their practices. The American Academy of Dental Sleep Drugs (AADSM) simply launched on-line coaching modules that provide a handy and easy option to proceed schooling in dental sleep drugs–and reap the benefits of the rising alternatives within the area. With these persevering with instructional packages, it's now simpler than ever to realize extra information and keep on the forefront of latest analysis and rising developments in dental sleep drugs. Every on-line studying module can simply be streamed on any pc or cellular gadget. The price is $35 for members and $50 for non-members, and registrants can entry the course at their comfort by way of the AADSM web site for one yr. Now obtainable, the primary course, "Introduction to Sleep and Sleep Disordered Respiration," offers an summary of the present understanding of the character and physiology of sleep in addition to the causes, danger elements, penalties, and efficacy of the remedy of obstructive sleep apnea with CPAP. Future programs will cowl the next subjects:
To buy or study extra, go to the studying modules part of the AADSM web site. |
A Good Night time's Relaxation: The Greatest Sleep Apps |
A Stay Science information report examines the perfect smartphone apps out there available on the market to watch and enhance sleep. |
On-line monitoring system for sufferers with sleep apnea |
An help system has been developed by scientists, based mostly on telemedicine utilizing info and communication applied sciences, that permits a web-based every day monitoring of individuals with sleep apnoea-hypopnoea syndrome. The tactic proposed by the corporate is especially targeted on affected person adherence to remedy as solely 30% of sufferers efficiently obtain to adapt to it. |
Over-the-counter sleep aids linked to dementia |
Greater dosage or lengthy-time period use of widespread medicine with anticholinergic results is linked to considerably elevated danger of dementia - together with Alzheimer's - says giant research. |
Elevated danger of hypertension in individuals with insomnia |
A big sleep-monitoring research has discovered a hyperlink between hypertension and insomnia, suggesting a connection between a 24-hour state of hyperarousal and raised blood strain. |
Why all-nighters do not work: How sleep and reminiscence go hand-in-hand |
Brandeis researchers observe an unknown connection between sleep and memoryWant to ace that check tomorrow? This is a tip: Put down the espresso and hit the sack. |
Morphine after tonsillectomy 'probably life-threatening' for youngsters |
Research halted after researchers discover that using morphine to aid ache in youngsters after tonsillectomy surgical procedure led to harmful respiratory issues. |
Good Bedtime Habits Equal Higher Sleep for Youngsters |
Youngsters acquire higher and extra age-applicable sleep within the presence of family guidelines and common sleep-wake routines, in line with sleep researchers. The researchers discovered that nicely-established guidelines for getting good sleep, comparable to restricted caffeine and a daily bedtime, led to enough sleep amount and sufficient sleep high quality. In distinction, when mother and father and youngsters had digital units on within the bed room after bedtime, sleep deficiency was extra probably. Decreasing the encroachment of know-how and media into sleep time and supporting properly-recognized sleep hygiene rules ought to be a spotlight of public well being intervention objectives for sleep well being, the researchers say. Orfeu Buxton, now an affiliate professor of biobehavioral well being at Penn State, led a staff conducting the 2014 Nationwide Sleep Basis Sleep in America Ballot, "Sleep within the Trendy Household," whose general goal was to acquire a present image of sleep in households with a minimum of one faculty-aged youngster. The outcomes are revealed at this time in Sleep Well being. The researchers evaluated US households with youngsters aged 6 to 17 years previous by way of Web-based mostly interviews. A complete of 1,103 mother and father or guardians of a mean age of forty two accomplished surveys; fifty four% have been feminine. "We have been concerned about parental notion of the significance of sleep period and sleep high quality, habits, and routines of the households and youngsters, and obstacles stopping sufficient sleep," Buxton says in a launch. In response to researchers, though nearly all of mother and father endorsed the significance of sleep, ninety% of youngsters didn't sleep the complete period of time advisable for his or her age group. A number of the main penalties of poor sleep amongst youngsters and adolescents are behavioral issues, impaired studying and faculty efficiency, sports activities accidents, issues with temper and emotional regulation, and a worsening of well being-associated points together with weight problems. Proof additionally signifies that in adolescence, lack of sleep could also be associated to excessive-danger behaviors reminiscent of substance abuse, suicidal behaviors, and drowsy driving. Vital predictors of age-adjusted adequate sleep period—estimated conservatively as at the least 9 hours for ages 6 by means of eleven years and a minimum of eight hours for ages 12 to 17 years—included mum or dad schooling, common enforcement of guidelines about caffeine, and whether or not youngsters left know-how on of their bed room in a single day. "We've got beforehand demonstrated the unfavorable impact that use of sunshine-emitting know-how earlier than bedtime can have on sleep, and now on this research we see how parental guidelines and routines relating to know-how can affect the amount and high quality of their youngsters's sleep," says Anne-Marie Chang, assistant professor of biobehavioral well being at Penn State and co-writer of the research. Chang and colleagues just lately confirmed that studying on an iPad earlier than bedtime, in comparison with studying a print e-book, can impair sleep, delay circadian timing, and degrade alertness the next morning. "An necessary consequence of our trendy-day, 24/7 society is that it's troublesome for households—youngsters and caregivers each—to get enough sleep," Buxton says. "Sleep within the household context frames sleep as involving interactions between all members of a family and interactions with the surroundings of the house in addition to exogenous elements like work or faculty affecting any member." A number of potential causes for poor sleep embrace using know-how within the bed room, difficult and busy day by day schedules with competing work, faculty, social, and leisure actions, in addition to neighborhood noise from vehicular visitors, business or industrial exercise, and neighbors. Inside the household dynamic, a constant bedtime routine improves sleep, whereas tv use within the bed room usually is related to curtailed sleep. "Good high quality and adequate sleep are very important for youngsters," Buxton says. "Identical to a nutritious diet and train, sleep is essential for youngsters to remain wholesome, develop, study, do properly in class, and performance at their greatest." |
Not Everybody's Inner Clock Is Set for the 9-to-5 |
Sleep issues put some staff out of sync with conventional schedules and are estimated to value employers $2,000 per worker in misplaced productiveness yearly, studies The Atlantic. |
Sleeping with Pet Might Worsen Sleep Points |
Baylor School's Dr Mary Rose says pets ought to sleep in beds of their very own. |
Mike Napoli Enduring Lengthy Restoration from Sleep Dysfunction |
Boston Purple Sox baseball participant Mike Napoli lately underwent surgical procedure for sleep apnea and recounted the small print to Comcast SportsNet. |
Swans' New Sleep Pods |
The Sydney Swans, an Australian soccer workforce, has added sleep pods to its change room to permit gamers to relaxation and recuperate, as indicated on a Swans Media information report. |
FAA to Situation New Sleep Apnea Steerage on March 2 |
On March 2, the Federal Aviation Administration (FAA) will challenge new medical steerage to Aviation Medical Examiners (AMEs), the company stated on Friday. The brand new steerage will incorporate business and Congressional suggestions balanced with FAA and Nationwide Transportation Security Board (NTSB) security considerations about pilots flying with obstructive sleep apnea (OSA). Based mostly on suggestions from business on the FAA's draft steerage, the brand new steerage doesn't depend on physique mass index (BMI) and permits a pilot to maintain flying throughout analysis and remedy. The FAA plans to publish the brand new steerage within the FAA Information for Aviation Medical Examiners on March 2, 2015. |
FMCSA: Medical Examiners Ought to Depend on "Medical Coaching and Experience" for OSA Analysis, Remedy |
In a bulletin issued this month by the Federal Motor Service Security Administration (FMCSA), the company reminds its licensed medical experts to make use of their "medical coaching and experience in figuring out whether or not a driver reveals signs and/or a number of danger elements for OSA [obstructive sleep apnea]." "The present laws and advisory standards don't embrace tips regarding OSA screening, analysis, and remedy," the bulletin states. "Medical experts ought to depend on their medical coaching and experience in figuring out whether or not a driver reveals signs and/or a number of danger elements for OSA, and they need to clarify to the driving force the idea for his or her choice if the examiner decides to concern a medical certificates for a interval of lower than two years to permit for additional analysis, or to disclaim a driver the medical certificates." The bulletin seems to provide medical experts large latitude in screening, analysis, and remedy choices. The bulletin states that house sleep checks that guarantee chain of custody are acceptable diagnostic instruments and that weight reduction and oral home equipment are included within the spectrum of acceptable remedies for truckers. Particularly, the bulletin states:
The FMCSA additionally states that drivers with "average-to-extreme OSA" are the first security aim, defining that as an AHI larger than or equal to fifteen. |
Progress with New Product Launches Helps ResMed Obtain Double-Digit Progress |
ResMed's income for the second quarter ended December 31, 2014, was $423.zero million, a ten% improve in comparison with the quarter ended December 31, 2013. Internet revenue was $ninety one.2 million, a rise of 5% in comparison with the quarter ended December 31, 2013. "We're happy to report robust double-digit income progress, demonstrating wonderful progress with our new product launches," says Mick Farrell, ResMed CEO, in a launch. "We achieved strong business efficiency throughout all areas, together with double-digit progress within the Americas." Farrell continues: "Through the quarter, we continued to roll out the ResMed Air Options Platform with the launch of our AirCurve 10 collection of cloud-related bilevel units. We additionally continued the worldwide roll-out of our new life help air flow system, the Astral platform. We drove shopper consciousness of sleep by launching the S+ by ResMed, the world's first non-contact sleep administration answer that helps you monitor and enhance your sleep well being; we additionally built-in the S+ with Apple HealthKit….We drove prime-line income progress within the first half of this fiscal yr by launching a robust, progressive portfolio of merchandise and options. Long run, we're targeted on our technique to proceed to develop our core sleep apnea market, in addition to to spend money on excessive-potential progress alternatives: serving to sufferers with COPD, neuromuscular illness, and cardio-respiratory circumstances. Our outcomes this quarter present that our options proceed to satisfy the wants of our key buyer teams, together with sufferers, physicians, healthcare suppliers, and payers. We're executing to our mission: enhancing affected person high quality-of-life, decreasing healthcare prices, and stopping persistent illness development." Evaluation of Second Quarter OutcomesWithin the second quarter of fiscal yr 2015, income within the Americas was $231.zero million, a 12% improve over the prior yr's quarter. Income in mixed Europe and Asia Pacific was $192.zero million, an eight% improve in comparison with the quarter ended December 31, 2013. Gross margin within the second quarter was sixty two.2%, decrease than the prior yr, primarily resulting from an unfavorable product combine and declines in common promoting costs, which have been partially offset by manufacturing and provide chain enhancements. Promoting, common, and administrative bills have been $122.5 million for the quarter, a ten% improve over the quarter ended December 31, 2013. SG&A bills have been 29.zero% of income within the quarter, in comparison with 29.1% within the quarter ended December 31, 2013, primarily as a result of larger advertising prices related to current product releases and a rise in variable worker compensation prices. Analysis and improvement bills have been $29.three million for the quarter, or 6.9% of income. R&D bills decreased by 1% in comparison with the quarter ended December 31, 2013. Working revenue for the quarter was $109.1 million and money move from operations was $106.zero million. Amortization of acquired intangible belongings was $2.three million ($1.7 million, internet of tax) through the quarter. Inventory-based mostly compensation prices incurred through the quarter of $eleven.7 million ($eight.1 million, internet of tax) consisted of bills related to worker fairness grants, and the corporate's worker inventory buy plan. |
Decreasing Work-household Conflicts Helps Individuals Sleep Higher |
A multi-establishment workforce of sleep researchers just lately discovered that staff who participated in an intervention aimed toward decreasing battle between work and familial duties slept an hour extra every week and reported larger sleep sufficiency than those that didn't take part within the intervention. The research is revealed within the inaugural difficulty of Sleep Well being, the journal of the Nationwide Sleep Basis. "Growing household-supportive supervision and worker management over work time benefited the sleep of a whole lot of staff, and even larger results could also be potential if sleep is overtly addressed in office interventions," says lead writer Ryan Olson, PhD, of Oregon Well being & Science College, in a launch. "The Work, Household, and Well being Community Research intervention was designed to scale back work-household battle. It didn't instantly tackle sleep, but sleep advantages have been noticed." The invention targeted on the US staff of an info know-how agency. Teams of randomly chosen managers and staff participated in a three-month social and organizational change course of that included interactive periods with facilitated discussions, position-enjoying, and video games. Managers have been additionally educated in household-supportive supervision and self-monitored how they utilized the coaching on the job. Knowledge have been collected by means of qualitative interviews 12 months after the intervention was launched and by actigraphy. Actigraphy measures of sleep high quality and amount have been taken initially of the intervention, to determine baseline measures for individuals, and 12 months after the intervention. Every of the 474 individuals' exercise recordings have been evaluated by two scorers, who recognized durations of sleep relative to every participant's waking actions. "I applaud the methodological rigor of Olson and colleagues' strategy to assessing the Work, Household, and Well being Community Research's impact on the sleep period and high quality of an actual world inhabitants," says Dr Lauren Hale, editor-in-chief of Sleep Well being. "This research demonstrates that interventions unrelated to sleep can enhance sleep within the inhabitants. Moreover, these findings function a reminder that there are alternatives to deploy progressive interventions to enhance sleep." The authors had hypothesized that each sleep period and insomnia can be improved within the research's twelfth month; secondarily, they hypothesized that any enchancment in sleep high quality and period can be mediated by staff' enhanced management over their work time and lowered work-household battle assessed on the sixth month after baseline. Researchers created a statistical mediation mannequin that accounted for the a number of temporal elements of actigraphic sleep knowledge and participant traits. "Right here we confirmed that an intervention targeted on altering the office tradition might improve the measured quantity of sleep staff acquire, in addition to their notion that their sleep was extra enough," says lead investigator Orfeu M. Buxton, PhD, Pennsylvania State College (with secondary appointments at Harvard and Brigham and Ladies's Hospital). "Work is usually a calling and inspirational, in addition to a paycheck, however work shouldn't be detrimental to well being. It's potential to mitigate a few of the deleterious results of labor by decreasing work-household battle, and enhancing sleep." The researchers plan to proceed this line of research and join future office interventions with personalised interventions to assist people enhance their sleep. |
Mind Researchers Uncover Similarities Between Dreaming, Wakefulness |
Researchers from the Max Planck Institute for Human Improvement in Berlin and the Max Planck Institute of Psychiatry in Munich have found that the mind space that permits self-reflection is bigger in lucid dreamers. Thus, lucid dreamers are probably additionally extra self-reflecting when awake. Lucid dreamers are conscious of dreaming whereas dreaming. Typically, they will even play an lively position of their goals. Most of them, nevertheless, have this expertise solely a number of occasions a yr and simply only a few virtually each night time. Web boards and blogs are filled with directions and recommendations on lucid dreaming. Probably, lucid dreaming is intently associated to the human functionality of self-reflection—the so-referred to as metacognition. Neuroscientists from the Max Planck Institute for Human Improvement and the Max Planck Institute of Psychiatry have in contrast mind buildings of frequent lucid dreamers and members who by no means or solely not often have lucid goals. Accordingly, the anterior prefrontal cortex, ie, the mind space controlling acutely aware cognitive processes and enjoying an essential position within the functionality of self-reflection, is bigger in lucid dreamers. The variations in volumes within the anterior prefrontal cortex between lucid dreamers and non-lucid dreamers recommend that lucid dreaming and metacognition are certainly intently related. This concept is supported by mind photographs taken when check individuals have been fixing metacognitive exams whereas being awake. These photographs present that the mind exercise within the prefrontal cortex was greater in lucid dreamers. "Our outcomes point out that self-reflection in on a regular basis life is extra pronounced in individuals who can simply management their goals," says Elisa Filevich, publish-doc within the Middle for Lifespan Psychology on the Max Planck Institute for Human Improvement, in a launch. The researchers additional need to know whether or not metacognitive expertise could be educated. In a comply with-up research, they intend to coach volunteers in lucid dreaming to look at whether or not this improves the potential of self-reflection. |
Continual insomniacs might face elevated danger of hypertension |
Insomniacs who take longer than 14 minutes to go to sleep face a higher danger of hypertension, in accordance with new analysis. This research is the primary to check whether or not insomnia with physiological hyperarousal, outlined as an extended time to go to sleep, is linked to hypertension. |
Good bedtime habits equal higher sleep for teenagers |
Youngsters get hold of higher and extra age-applicable sleep within the presence of family guidelines and common sleep-wake routines, based on sleep researchers. |
Interventions to scale back work-household battle 'enhance sleep' |
A brand new research has proven that decreasing battle between work and household duties led to an enchancment in sleep period and high quality. |
Decreasing work-household conflicts within the office helps individuals to sleep higher |
Staff who participated in an intervention aimed toward decreasing battle between work and familial obligations slept an hour extra every week and reported larger sleep sufficiency than those that didn't take part within the intervention, a research exhibits. |


text:
The year is 1792 and Conrad Saul (You) have been sent to Castle Gordianus because the village has been attacked by bandits for several days, and the Knights from Castle Gordianus were supposed to protect the village from any potentional threats. But the Knights hasn't been seen for weeks... where are they?
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The best work of one of Poland's greatest younger poets "I love to swim in the sea, which keeps" "talking to itself" "in the monotone of a vagabond" "who no longer recalls " "exactly how long he's been on the road. " "Swimming is like prayer: " "palms join and part, " "join and part" "almost without end." --from "On Swimming" This selection ... Read More The best work of one of Poland's greatest younger poets "I love to swim in the sea, which keeps" "talking to itself" "in the monotone of a vagabond" "who no longer recalls " "exactly how long he's been on the road. " "Swimming is like prayer: " "palms join and part, " "join and part" "almost without end." --from "On Swimming" This selection draws from Adam Zagajewski's English-language collections, both in and out of print; it also includes work from his early books, "Communique" and "Butcher Shop," as well as new poems that are among Zagajewski's most refreshing and rewarding: meditations on human frailty and vigor, they are vividly imagined, of great clarity of thought and scrupulous attention to the natural world. In Clare Cavanagh's lucid, graceful translations these poems share the vocation that allows us, in Zagajewski's words, "to experience astonishment and to stop still in that astonishment for a long moment or two." Read Less
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Near Fine in Very Good DJ. New and Selected Poems. 285 pp. 8vo. Quarter cloth in dj. Scuffing and lt edgewear to dj, sl. bumping to corners, very tiny tear to upper corner. Light edgewear to book, sl. bumping to sp. foot. Translated by Clare Cavanagh and Renata Gorczynski, Benjamin Ivry, and C. K. Williams.
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Perfect place 4 min walk to main place, superclean and cosy room, quiet, free wifi everywhere, nice breakfast, good price. I stayed 1 week and i can defenetly recommend ! Ps: all Sisters speak good Italian in case helpful !!!
- Also Known As:
- Bridgettine Convent Guest House Hotel Turku


text:
Yesterday an education panel was held at the New York Public Library. The panel, sponsored by the Wall Street Journal and Intel Corporation, starred three leftists who continued "the ongoing debate inside the Democratic Party…
Home Tag: New York Public Library
Topic: New York Public Library
Faculty Lounge
VCU ditches SAT scores for Applicants
Scientists Balk at Global Warming and 2014 was the "Hottest Year" claim
New York Times Columnist Screams Racial Profiling after Son is Detained by Yale Police
Obama drops his Tax on College Savings Plans
Out-Of-Print Humanities Textbooks will become Free e-Books
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Crapitalism: A Book Review of Crony Capitalists
Jason Mattera, a New York Times best-selling author and well-known for his interviews with less-than-reputable political figures in Washington, D.C., has written a new book entitled, Crapitalism: Liberals Who Make Millions Swiping Your Tax Dollars….
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Before you find him on offer as a university speaker or course, you may want to read the meticulously documented story of Cop killer Mumia Abu-Jamal by former Accuracy in Academia executive director Dan Flynn.


text: Meta Battle Subway PokeBase - Pokemon Q&A Login Register All Activity Questions Unanswered Tags Users Ask a Question Rules Chat What's wrong with my Zorua? 0 votes In my White Version 2, I got N's Zorua. Well, that's okay, but for some reason, when I throw it in the world tournament it doesn't use Illusion. I now understand why (it doesn't have a Pokemon after it in my team so it can't use Illusion), but it sparkles like it's shiny or something. I've looked and it's definitely NOT shiny. I'm REALLY confused. ~Disdestroyer~ problem black-white-2 zorua weird shiny asked Feb 11, 2013 by disdestroyer Please log in or register to add a comment. Please log in or register to answer this question. 2 Answers 0 votes It sparkes beacuse it is one of N's Pokemon.All of N's Pokemon sparkle. Upon encountering one of N's Pokémon, the game will notify by showing a sprite entry animation that is similar to the Shiny Pokémon sprite, but instead has its own sound and the Pokémon is surrounded by green and yellow diamond lights. -bulbapedia ILLUSION N's POKEMON answered Feb 11, 2013 by MK 42 edited Feb 11, 2013 by MK 42 Please log in or register to add a comment. 0 votes Illusion only works if a Pokemon is able to fight which is in the 6th place of your party and that Pokemon must not be another Zoura. Here is the link for illusion if I didn't fully answer: http://pokemondb.net/ability/illusion answered Feb 11, 2013 by Troll Patrol i think he asks why does Zorua sparkle. from experience with N's Zorua on my copy of black 2, Zorua sparkles when either the 6th pokemon is fainted or is out in battle (if it is a double or tripple battle) Please log in or register to add a comment. Related questions What's wrong with my Latios? What's wrong with my Dratini? Whats wrong with Arceus? What is wrong with my copy of Y? Can you get shiny zorua in black 2? If I breed a female Zoroark with a shiny male pyroar will I get a shiny Zorua? What's wrong with my Explorers of Sky Shaymin? What happened with my mystery gift? Useful Meta Posts How to change your username How to add a user avatar Why was my post hidden? The points system Question etiquette Flags vs Downvotes Anime FAQ


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Superman Caricature from a Photo Print
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This burger was one of the best I've had. Waitress said they use something special on them. My husband had the chicken fried steak and was very pleased. Beer batter fries also good. Biggest coke/tea glass I've ever had.
This burger was one of the best I've had. Waitress said they use something special on them. My husband had the chicken fried steak and was very pleased. Beer batter fries also good. Biggest coke/tea glass I've ever had.
The burger was juicy not greasy and cooked just right. I asked the waitress whether I should get the potato chips or fries - she told me to get the chips and she was right. Nice, fresh chips, with the right amount of salt. I went on a workday and got there a bit early to beat the crowd. The... More
Varied menu. Original and oh so tasty recipes. Wonderful and friendly service. Unique and awesome atmosphere. Has been featured on Texas Country Reporter and several other journals and magazines. Come see for yourself. I've been eating here for almost 40 years and still find something new to treasure each time I eat here. BTW - I'm not THAT old. Late... More
The new management has made some nice changes. Staff is friendly. Place has been packed at lunch so service has been a little slower but food is fresh and hot. Lunch special is reasonable. Fried pickles were good and crispy. Swiss burger was tasty with good sweet potato fries. Chicken fried steak was a little chewy. Waitstaff is not big... More
The Rosebud has NOT closed. Our hours are Monday-Friday 11:00 am to 2:00 pm. Friday evenings we are open from 5:30 pm to 9:00 pm with live music. We will be open on some Saturdays & will post them on Facebook.
Great meals for lunch! Quick service and awesome specials! I love the malts! Friday night they have singers and great ribeye cooked to perfection! Can't wait to Congr back!!!
We stopped for lunch in Victoria on our drive from Houston to Rockport. We each had the cheeseburger with sweet potato fries. Burgers were like homemade and the fries were just right too - not soggy nor overdone. I didn't think it could get any better until I ordered the old-fashioned chocolate malt on a dessert whim. Heavens to Betsy... More
Service was very slow. Food was good but took a long time to get served. They wait staff seemed to be overwhelmed.
If a good old fashion burger and fries or onion rings is what you are looking for, this is the place. Its not very fancy and not very big but has the bestest burger in Texas. Nuf said.
This place takes me back to the soda fountain fifties. Great ambiance and decor. The food is good, too. That's a bonus. Hamburgers, po-boys, and beer-battered fries all are made just right. Enjoy the history as well as the food. Entertainment some nights, check with them.
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Respond to Review of CLOSED: Vegetarian Delight
by fearless
Review: How much you would enjoy this place I think is quite dependent on the type of food that you enjoy eating. For me it was ok but really not the sort of thing I enjoy. For thos of you who live in Adelaide it is quite "Gouger St" in terms of the dishes being heavy on sauce and quite often having fillers like onion and potato thrown in because it is cheap. However, if you are a fan of a place heavy with mock meats do pay this place a visit.


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Resolution: standard / high Figure 8. Example of the similarity analysis in an artificial network. The network similarity σ for an ER graph (n = 250 nodes, m = 1245 edges) and its rewired versions has been computed as a function of the randomization
depth r (number of rewired edges). In each randomization step one endpoint of an edge is rewired
to another randomly chosen node.
Müller-Linow et al. BMC Systems Biology 2007 1:44 doi:10.1186/1752-0509-1-44 |


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I don't remember having seen this one recently. Since we just did LOs about us I thought it would be fitting that this challenge be about our DHs/SOs.
Deadline is midnight on Nov 22nd.
Please remember to remove your siggies.
Last edited by coolmama72; 11-15-2009 at 10:17 PM. Reason: remove sticky request in title
perfect! I just bought something this past weekend to do a layout about Wayne!
and I just had a photo printed of DH that I thought would be perfect for a layout. (but I didn't get printed the size I'd use for a layout ... now I will have to )
DH as dad.
Last edited by auret; 11-12-2009 at 02:49 PM.
That's really good Beckie. I bet she'd love to see that too. Great pic of them both!


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Elf Bowling 1&2 Cheats & Codes
| Cheats | Unlockables | Hints | Easter Eggs | Achievements
Be the first to submit a cheat for Elf Bowling 1&2.
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Game Details
Published by:
Ignition Entertainment
Developed by:
Black Lantern Studios, NStorm
Release Date:
United States: November 25, 2005
T for Teen
: Crude Humor, Mild Violence, Suggestive Themes
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An RPG similar to all the other main Pokemon titles: the story takes place over land and sea and pits you against Team Aqua and Team Magma.
POKÉMON RUBY and Sapphire take place in an all-new region known as Hoenn. When the game starts, you get to decide to control either a boy or…
We've seen the future, and it's all about Pokémon FireRed and Pokemon LeafGreen. The new games are set in Kanto, the region where Pokémon…


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Enriching the lives of children by working with the adults who affect their lives
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To enrich the lives of children by working with the adults who affect their lives – parents, caregivers,
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Crazy Taxi: City Rush releasing this ThursdayCrazy Taxi creator Kenji Kanno has returned to the beloved arcade racing property for a new game, Crazy Taxi: City Rush, which would normally be cause for celebration except this is designed for mobile. Drat. Our dream of new console installment remains exactly that -- a dream. Anyway, Sega says City Rush will be out on iPhone and iPad this Thursday, July 31. Maybe curiosity will get the better of you. The original game is available for mobile devices as well, but for me, it's the same crucial issue of not wanting to play Crazy Taxi with touch controls. Still have my Dreamcast, though. And that Offspring song in my head. Comments not appearing? Anti-virus apps like Avast or some browser extensions can cause this. Easy fix: Add [*].disqus.com to your software's white list. Tada! Happy comments time again.
Did you know? You can now get daily or weekly email notifications when humans reply to your comments.
The return of news on Dtoid's YouTube channel? Lets start with Pokkén Tournament 12:00 AM on 01.24.2015 Tekken 7 lead annoyed you don't like the catgirl so she's Asia/Europe-exclusive 1:30 PM on 12.09.2014 |


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2 Nowhere near as good as the BooksNicciD | 22/06/2009 | See all NicciD's reviews (1)This film lets the books down badly. Becky Bloomwood is british in the books and lives in the UK. But in the film she is suddenly American. Its VERY irritating to watch if you are a huge becky fan from reading the books. Isla Fisher does play Becky very well its just a shame its with the wrong accent.I wouldnt bother with the film. Stick to the books and you will get more laughs!!!!I know Sophie Kinsella has been slated on her website for allowing this awful americanised version of her book to be made and fans feel she sold out to hollywood and the cash.Its such a shame as i hope this film doesnt stop people reading the books as it just doesnt do them justice.
5 Isla Is So PrettyKimmykins83 | 05/08/2009 | See all Kimmykins83's reviews (108)I love love LOVE this movie so much it's untrue!It's the ultimate perfect girlie treat with something for everyone!I have yet to read the book, but will be doing so for sure very soon!
5 Oh my days - watch this movie!shoppinggirl | 27/04/2009 | See all shoppinggirl's reviews (13)I went to see this movie because i am a bit of a shopaholic myself and my dad said it would do me good! It was hallarious! It does help you cut down on your shopping as well but it is so funny! The main character Rebecca is a shopaholic and everythime she goes into a shop she has to buy something until her card was - declined. She realy wants to get back on track and wants to take up a job for her favourite fashion magazine but instead ends up working at a 'Savings magazine' and going to 'Shopaholic anonomous' and with the hepl of her best friend tries to pay off her bills and throw out her clothes, but she also falls in love and gets herself into even more trouble. You will have to watch it to find out waht happens. As I said it is extremely funny and I would recomend it to all girls as it is a Chic Flic. You only have to wach the trailor to get you hooked. So get this on DVD, I promise you won't regret it! I am deffinetley buying this.
5 amazin!!carlsberg21 | 21/02/2009 | See all carlsberg21's reviews (2)Sucha good film!saw it in cinema last night and was sore from laughin so much.girls true film, all shoes,bags clothes,just loved it!!esp bit with fan dancin!!!def recommend it!
4 Loved itlayla500 | 22/07/2009 | See all layla500's reviews (1)This adaptation was very different from the book, the story chose to go down different avenues and a few of the characters we missing which resulted in rebecca not having any depth. As a film on its own it was perfect to sit with friends and laugh with, a perfect feel good film that I could watch over again.


text: Had a very tiring day, helping out /going along to doctors appointments with a relative. We were passing by Zoup. So I decided to stop for a takeout. Staff were great. So nice & welcoming. Exactly what I needed after a long day. I tried a couple of samples. Had a cup of crab/corn chowder soup & a piece of... More


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"Escape the city for a day or two..." Singapore Off The Beaten Path Tip by lynnehamman
Singapore Off The Beaten Path: 211 reviews and 406 photos
We have visited Singapore many times, and felt the need to do something different, but nearby.
Bintan Island is only a one hour trip away by fast ferry, and I highly recommend it.
Being an Indonesian Island, one needs a visa, which can be obtained upon entry.
Bintan is ecologically very interesting, and has a few excellent golf courses, and beautiful flora.
The island itself has a few resorts, and we stayed at Bintan Lagoon resort, which was perfect in every way. Relaxing, great beach for walking (swimming we avoided because of strong currents)- fabulous food (breakfast is included) and lovely architecture. Our room was large, airy, with a balcony and sea view. There is a huge outdoor pool with pool bar, and a health/beauty spa for pampering.....
I recommend Bintan for a short getaway from the city.
(for more info, see my Bintan page)
You can book a trip to Bintan at the Singapore Visitors Centre in Orchard Road, or at travel desk of your hotel.
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News » Published 1 Week ago
Is this Nina Dobrev the Actor?
Share your thoughts on this image?
25th January 2015 @ 04:22pm
Rumours are circulating that Nina Dobrev is bothered by the relationship of ex-boyfriend Ian Somerhalder but her gorgeous look at the Nine Zero party in ...
25th November 2014 @ 08:12pm
The Vampire Diaries executive producer Julie Plec says that the Damon and Elena rain kiss was to please the fans
10th July 2014 @ 02:24pm
Alexander Ludwig is the envy of many men as he has just been selected the brand ambassador for Bulgari and is rumoured to be dating the beautiful Nina D ...


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Tap Here to view the Mobile Optimized TFLN
Call me when your ready for an explanation about the ham in your vagina.
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somebody got porked. literally.
Sweet121, something you should've learned in health class, babies are in your uterus, not your vagina...
Maybe he confused the discharge for cheese......even I'm grossed out by this comment.
College tuition? Is it really THAT exspensive?
The other white meat.
Taking beef curtains a little to seriously.
Whiskerbiscut that's just nasty.
Bone in or spiral cut?
Hopefully it was honey glazed.
Well nobles ham is not beef. At all
its better than tuna...
Is ham a euphemism for "baby"? If not I'm disturbed by this text.
Damn Just Damn
Chipped ham?
It's called a ham wallet for a reason
I'm going with a food fetish....
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Choosing from a plethora of moving companies in Apollo Beach? Receive the service you expect when you turn to Allied Van Lines, who will make your move a breeze. We're confident in the service we provide our customers because we adhere to strict safety standards and our agents employ dedicated, punctual professionals.
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Your favorite Apple, iPhone, iPad, iOS, Jailbreak, and Cydia site.
Thread: What Do Samsung's Plans mean for the App World?
09-03-2009, 01:03 AM #21Look forward it...
Horray samsung!!!
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muaddib, you do know, AS SOON as you said that, the thread was kaput... Why...WHY.
I'm sorry, but I'm sure if you put 2 and 2 together you'll find this pertains to Apple in some way. Telling a writer (an experienced one at that) to GTFO withis hardly appropriate behavior for someone with >1000 posts, is it?
The last time cash checked, most of the visitors used Internet Explorer; an Internet browser for Windows.
You are wrong.Last edited by dale1v; 09-03-2009 at 02:04 AM.
[/LEFT][QUOTE]Microsoft owns the internet through Hotmail. The .HTML is short for Hotmail, so all .HTML files are MS files.[/QUOTE][URL="http://twitter.com/dale1v"][SIZE=2][COLOR=Cyan][I]twitter.com/dale1v[/I][/COLOR][/SIZE][/URL]
^You are absolutely correct. It was just one of those days....I woke up, went through my inbox, and every comment I read had something to do with Windows or OSX bashing. So I clicked on the first one, muaddib's comment, and put my foot down so to say.
But you are right, this does pertain to us here and to the new writer, I apologize, keep up the good workIf I helped you, hit the button or be Banned!
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I based this dress on this picture I found on Google images: http://cloud.faout.com/S/201202/goods-img/1328830308267-P-226495.jpg . I used a Vogue pattern to base the bodice and sleeves on (opening up the neckline and making it more fitting), and the skirt pieces I measured and estimated, from my own body and by how much lace had (with some of my mom's help).
The skirt for the lining is an A line skirt, with two pleats in the front and two in the back (for fullness). And the lace skirt is a tiered gathered skirt.
I used a Rayon, cotton lace from my mom's stash, and a polyester purple fabric for the lining.
Apr 12, 2013, 03.34 AMby jaslyn117
Thanks all of y'all! :)
Apr 3, 2013, 12.15 PMby Kovu
this is beautiful!
Apr 2, 2013, 02.28 AMby neveenkarnes
very nice. great job!!!!
Apr 1, 2013, 10.45 PMby liliv-1
It's adorable!
Apr 1, 2013, 09.39 PMby Kocotte
it is so romantic, this fabric is wonderfull
Apr 1, 2013, 09.26 PMby SewNotWork
great job! very nice!
Apr 1, 2013, 06.25 PMby lmain83349
Love it, especially the purple underneath. Good job.
Apr 1, 2013, 05.53 PMby Mary Athey
its a really lovely lace fabric and the purple under it makes it stand out. it fits you very well and is gorgous on x
Web Seminar
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The kids are sure to steal the show in this charming collection of classic, elegant pieces.
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She made this dress for her high school graduation, and it looks fab!


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I recently took my Springfield 1911A1 Widebody to a great local 1911 gunsmith- Glen Riddle/G Square Custom to have some new sights,trigger job,hammer,and just a good going through. I must say he did a great job,and had fast service. He installed some Meprolight-Tru Dot adjustable night sights,and I really like them. He also recut and polished the ramp,new hammer,grip safety,and now I have a 3-4lb trigger that is really nice over what it had from the factory. I couldn't believe what he charged for all the work he did on this gun-$175.00 and that included the sights,they cost $120.00. What a great guy to deal with! You guy's need to check out his website,he builds some really nice custom 1911's. G Square Custom Here it is before: After: I haven't been able to get to the range yet,but I did put a few rds through it here at the house to make sure it functioned and to try out the trigger. It should be a great gun now!!
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Nice work and I can't believe the price!! Thanks for the link Tx!!
People get the government they deserve.
That's an outstanding price for that amount of work. Enjoy that rascal.
Very nice outcome Tx! I NEED to find a gunsmith like yours. Not for the price, but for the trust.
Thanks Cane. I know want you mean about trusting people with your firearms. I met this one several years ago,he always has a table at the Original Ft.Worth Gunshow,and he's a super nice and smart man when it comes to building 1911's. I talked to several people in the firearms industry before I decided to try him out. As far as the price of his work,that was a complete surprise and one I really liked!


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Stand up stands up
Ashraf Khalil explores how home-grown stand-up comedy could become a big business in Egypt. But will any of the aspiring comics be able to turn it into a career?
August 22, 2010 3:40 by Ashraf Khalil
The scene was the Sawy Cultural Center, a multi-stage performance space tucked underneath a busy bridge in the upscale central Cairo district of Zamalek. The room was badly ventilated and sweltering hot, with blinding stage lights that forced some audience members to don sunglasses. The event was essentially a massive night-long social and comedic experiment.
One after another, with the capacity crowd roaring at almost every line, more than a dozen comedians took what is essentially an Anglo-American art form and gave it a decidedly Egyptian spin.
Tamer Farag, a 35-year-old professional tour guide, riffed cleverly on the bizarre linguistic games Egyptians play – incorporating English words like "coffee shop," "upgrade," and "jacket" into Arabic, then randomly applying Arabic grammar rules to them.
"So what's the plural of jacket?" Farag asked the crowd in Arabic. "No, it's not 'jawaacket,' that's low-class! All the chic people say 'jacketaat.' What's wrong with you?"
Noha Kato, a young woman who wears the hijab, talked about how hard it is for veiled women to find places to swim. Her options are either to find a pool with women-only hours or opt for the slightly ridiculous "Islamic swimsuit." "For people who don't know, it's like a diving suit with a ballet dress stuck on it. So you end up looking like a Muskateer," she said, drawing a huge laugh.
Kato, delivering her routine in fluent English, joked that at age 22, her parents are already fretting about her never getting married. "I feel like a yogurt cup with an expiration date stamped on my forehead," she said.
The year 2010 may just be remembered as the one that homegrown stand-up comedy turned the corner in Egypt. If so, the Feb. 19 comedy showcase known as Hysteria may be the moment that proved Western-style could thrive here. The stand-up scene has been bubbling below the surface for several years. Clubs and coffee shops have started hosting occasional stand-up nights, drawing on a growing pool of locals eager to perform. "It's going to be very gradual. It will still take time for people to catch up to it," the manager of the Cairo Jazz Club, Shady Hamza, said.
Hamza started experimenting with stand-up nights earlier this year, bringing in two or three comics to perform brief routines as an opener to the night's band. To his surprise, he discovered that his nightclub – which normally doesn't start filling up until 11 p.m., was packed by 8:30. "I'm excited about the idea and I want to be part of its growth," Hamza said.
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Those of you that attended my workshop in Paris on Saturday can download the slides from the link below:
Slides from LAMSIG / LONDOSA
Here are the slides from my talk on Saturday, they are in pdf format so you can download and save them.
Image conference slides
You can download the slides from my workshop at the image conference here :
IATEFL Harrogate Talk
These are the slides from my talk in IATEFL, you can download them as a pdf by clicking / saving the link under the slides
Slides from Izmir 15.03
You can download a pdf version of my slides here.
Right click on the link to save them to your computer.
Tunis Slides
TESOL France slides
You can download the pdf of slides from TESOL France here – (right click to save and download)
Slides from Leeds and London
Y0u can download the slides as a pdf here – Mobilising Leeds
Brazil – projects slides
Here are the slides for the projecting talk – please note some of you saw different versions of this talk. Right click on them to download.
HP talk links and slides
Here are the slides from the talk:
right click to download them.
Here are all the sources I used in my HP Talk in Peru and Brazil
Why didn't Harry Potter use google?
Kids' Cognition Is Changing—Education Will Have to Change With It
Text messaging over takes talking
Guardian Article on handwriting
Students thoughts on wikipedia
21st Century Skills: Learning for Life in Our Times
Mark Pegrum's digital literaces (though I recommend them in full in his book)
UNESCO booklet on teachers and technology
Incidental links (i.e. I mentioned them in passing)
Screen recording - jing, screenr
Adding subtitles – Overstream
If you have any questions then please either contact me on the blog or by email firstname.lastname@example.com