text:
Foreign Languages Publishing House
The name Foreign Languages Publishing House was given to two government-based publishing houses: a now-defunct publisher located in the former Soviet Union, and a currently existing one located in North Korea.
Moscow Foreign Languages Publishing House[edit]
The Foreign Languages Publishing House was a state run publisher in the Soviet Union that published Russian literature, novels, propaganda, and books about the USSR in foreign languages.[1] These included works by Lenin and Stalin.[1] It was headquartered at 21 Zubovsky Boulevard.
Pyongyang Foreign Languages Publishing House[edit]
The Foreign Languages Publishing House is the central DPRK publishing bureau of foreign-language documents, located in the Potonggang District of Pyongyang, North Korea.[2] It employs a small group of foreigners to revise translations of North Korean texts so as to make those texts suitable for foreign-language publication.
- ^ a b "Moscow : Foreign Languages Publishing House". University of North Carolina at Asheville. Retrieved 29 October 2013.
- ^ "Government Offices, North Korea Uncovered". Retrieved 29 October 2013.
External links[edit]
- A Year in Pyongyang, An autobiography of a foreign reviser, Andrew Holloway is available online.
- Foreign Languages Publishing House – electronic documents published by the Foreign Languages Publishing House in Pyongyang.
- Korean Publication – N. Korean official outlet
- North Korea Books – Canadian firm selling North Korean literature
See also[edit]
- Progress Publishers, another Soviet era printing house which published books and pamphlets in English on a wide range of topics.
This article about a North Korean company is a stub. You can help Wikipedia by expanding it. |


text:
Jonathan Lister is LinkedIn's vp/North American sales for marketing solutions, which means that he's in charge of growing the social network's brand advertising revenues.
It's a growing business—the company reported a 77 percent increase in ad sales to $50 million in Q4 2011.
We sat down with Lister recently in LinkedIn's regional office in New York, on the 25th floor of the Empire State Building (great views!). He told us how LinkedIn serves its clients, what kind of data it can offer, how it competes with Facebook ... and how LinkedIn could end up making your resume and your business card extinct.
Jim: Give my readers a broad overview of what you do and who you do it with.Jonathan: So I run North America marketing solutions. Marketing Solutions is our line of business that sells to partners. So we connect members with branding opportunities. We do this at scale, we do it globally. I happen to run the business in North America. That business is predicated on lots of information that members have chosen to give us about who they are, their identity, and who they know, their graph. Professionally who they're connected to – first degree, second degree, third degree.Jim: And this is different from the hiring solutions side?Jonathan: We have a line of business, Hiring Solutions, that sells to people who hire in the HR community. We have a line of business called Marketing Solutions that I run that sells to marketers. We also have a subscription line of business. Jim: And you have a new business with heads of sales organizations?Jonathan: We have a product that we sell into sales organizations, to heads of sales, that helps salespeople take advantage of some of the great things about LinkedIn. So specifically, one of the things it does is help people find people in organizations that they're not connected to. It helps people find people they would like to connect to at another organization via people at their organization who they're connected to. So what it does is it using the graph to find people at my company who are connected to someone that I would like to be connected to. In effect what's it's doing is helping businesses to eliminate the cold call. It's creating warm calls.Jim: So this is why sales people are obsessed with LinkedIn!
And your business card.
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subset: commoncrawl


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I wonder if anyone has come across a Mark Hammond POUNDER in Indiana, USA. He was the brother of my Grandmother and was born in Lambeth, Surrey in 1870 but was brought up in Bolton, Lancashire. I have just heard that he moved to Indiana in the USA (must have been sometime after 1891). I wonder if anyone knows anything about him? Martin Briscoe
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New York Rangers
Team Depth Chart of NHL Prospects
- Potential power forwards
- Defensive and two-way defensemen in system
- Depth in potential third/fourth line players
- No future number one netminder in system
- No purely offensive defensemen in system
Legend of Players' Leagues
- Pro
- Playing in N.A. Pro (NHL, AHL, ECHL, etc.)
- Playing in CHL (OHL, QMJHL, WHL)
- Playing in NCAA
- Europe
- Playing in Europe
- Junior
- Playing in Junior 'A' (USHL, BCHL, AJHL, etc.)
- Not Categorized Yet
Hartford's First Line of Defense: Tomas Kloucek"It's putting my 2 best defensemen together," is how Coach John Paddock responded when asked about teaming the rookie with senior defenseman Terry Virtue. Tomas played junior hockey from '95 to '98 in the Czech-Jr. League for Slavia Praha and last year for Cape Breton in the QMJHL. This year was his last year of junior eligibility and he said when asked about the Czech Junior Team winning the World Championship, "I almost went with the nationals. The National Team Organization decided to take only 5 players playing in North America, instead of 8. So, they dropped me." Coach Paddock assessed his rookie defenseman, "Well, Tomas Kloucek is a really, really good player and a really good prospect. He still could be playing junior hockey. He's only going to be 20 next year. He's a really solid defenseman and he kills penalties. His best assets are his skating, his strength, and his heart. He's going to be a number 4 defenseman in the NHL sometime soon." Linemate Terry Virtue said, "Tomas is a big, strong player that skates well. He's hard to knock down. He seems to be getting his feet wet on the ice more. He's really coming along well. I think what he has to do now, is skate with the puck more and see the ice better. That's going to come with time and experience. He's going to get a lot better." The Wolf Pack's new addition realizes that "there is always something to work on. I need to handle the puck better because here you clear the puck more." Reflections: A look at some Rangers ProspectsAs the season passes the mid point, hopes of a playoff birth grow with the better play each day of our beloved New York Rangers. However with many players in key positions hitting the wrong side of their careers one has to ask where the future is. With this years "successful" draft taking Pavel Brendl and Jamie Lundmark in the first round and later taking Dave Inman, Pat Aufiero and Johan Asplund later, what about the other drafts, one`s that showed so much promise and turned out, well not that promising. Rangers Quick Notes…with new blood inserted into the line-up in Radek Dvorak and back to back wins over the East leading Maple Leafs, the Rangers fall to lowly Carolina before a sparse crowd of 12,000. actually netted, many bright performers have been overlooked. I have added a little fun by using a "stats pack" projection based on how I think these players will do per season over the next 8 years or so. I welcome your opinions and stats pack guesstimate. Kim Johnsson-Defense Johnsson has been up and down of late but still remains a talented offensive GRADE: B+ FUTURE NHL STATS PACK PROJECTIONS: 76gp 11g 36a 47tp 63pim Mike York-Center GRADE: A- FUTURE NHL STATS PACK PROJECTIONS: 74gp 22g 39a 61tp 54pim Jan Hlavac-Wing Rangers News, Notes, Worlds and More….Pavel Brendl continues to impress the New York Rangers at the Junior Level. Brendl was named WHL player of the week after his 4-3-7 in 3 games performance and is currently leading the WHL in scoring with 33-31-64, one pt ahead of teammate Brad Moran(33-30-63). The upcoming World Junior A Championships begin Christmas Day and several New York Rangers prospects are to be donning their national team jersey. A preliminary listing includes: Pat Aufiero and Dave Inman (TEAM USA), Manny Malhorta and Jamie Lundmark (TEAM CANADA), Johan Asplund (SWEDEN), Arto Laatikainen (FINLAND). Of this group, many eyes will be on TEAM CANADA captain and seldom used New York Rangers center Manny Malhotra (6-3 218). Malhotra fell out of favor in New York with the emergence of Mike York and the resurgence of Alexander Daigle. Malhotra may be packaged to acquire a Keith Primeau or Bill Guerin type player. The World`s will provide him with the opportunity to showcase his talents and possible gain more ice time in New York. But Team Canada struggled early in a training match , falling 7-1 to SWEDEN. The USA fell to RUSSIA 3-1 as well. The baby Rangers continue to play well in Hartford (16-8-5-1) and one point behind Division Leader Portland. Derek Armstrong (11-20-31), Brad Smyth (17-13-30), Mike Harder (12-11-23) and Ken Gernander (8-13-21) are the leading scorers in Hartford and will represent Canada and Planet USA in the upcoming AHL all-star game. Tomas Kloucek has also been named to the Planet USA Team. |


text: The manga is looking pretty good... the series is okay, it only goes up to volume 4 of the manga though and Xebec messed up the animation style... so anyway, are they really going to make a season two? They should, to many things were left unexplained.. and oh my god did you see the kiss? I mean between Konoka and Setsuna.. why wasn't that in the manga... -sob-


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Demo Derby: Official PlayStation Magazine: Issue 58
Become Premium to Watch
The chaos and fun of Saints Row is fully intact in the underworld, but a new setting can only go so far.
Dimensions recaptures enough of Geometry Wars' thrills to stand as the best new dual-joystick shooter in quite a while.
The little mushroom man finally gets his name on the marquee, and the result is a charming, unique, and puzzle-heavy adventure.
Character »
Black Magic is one of the key types of magic in Final Fantasy games. Spells include those that deal damage, such a Blizzard and Thunder.
Eidolons are summoned creatures commonly found in the Final Fantasy series. They have alternatively been called terms such as Summons, Espers, and Guardian Forces depending on the Final Fantasy universe in question.
The Classical Elements are usually considered to be Earth, Water, Air and Fire. In modern science, the Periodic Table has increased the number of elements to 118.
The concept of affecting the universe through supernatural methods, breaking the fundamental laws of science.
An optional boss is a boss whose defeat is not essential to the plot and can be avoided. In some cases, they are stronger than the game's final boss.
Respawning is when a player or NPC dies and then reappears moments later - usually in a predetermined location or group of locations - while the game continues.
Enemies that are small, deal relatively low damage, and have low health, but make up for it by attacking in large numbers. Examples include Flood infection forms from Halo, Trites from Doom 3, or Crawlers from Resistance: Fall of Man.
A deceptively powerful enemy featured in many Final Fantasy games almost always wearing a brown cloak and equipped with a lantern and small knife. Infamous for being able to instantly KO one or all party members after slowly approaching them.
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I stayed for a business trip and found it very easy to locate the hotel. It's right off I 25, very close to many restaurants and shopping. It was a nice comfortable place to stay for a reasonable rate.
The only negative is the size of the fitness room. When I got up to work out I the morning there was actually a line to use the fitness room. 2 treadmills and an elliptical machine is just not enough. They do have a pool and whirlpool though.
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January 1 to January 30
Discover what you should be doing right now. Our experts share gardening advice, techniques, news, and ideas to make your garden the best ever.
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Found the same room at a different price? Tell us, and we'll offer to match it.
Directions - South Causey Inn, Stanley
4 | Visit England Assessed Inn | Ratings explained |
Located in over 100 acres of grounds, we overlook Beamish and are just a short drive away from the business and shopping centres of the Metro Centre in Gateshead, only 8 minutes away and the Cities of Newcastle and Durham with World Heritage Site Status. We overlook Beamish Museum, one of Europe's largest Open Air Museum's and other attraction nearby include Tanfield Steam Railway which is less than a mile away.
The Inn is also adjacent to South Causey Equestrian Centre, which houses 45 horses and a lively Riding School! Open all year. Archery instruction also available, as well as Air Rifle Shooting & Clay Pigeon Shooting. Plenty of free parking available. . Full Meeting Room facilities available. Discounted tickets for Beamish Museum (during Beamish Museums Summer season) & Tanfield Railway available.
DirectionsView directions provided by hotelFrom the South: Railway:Chester-le-Street Dunston Metro Centre (Gateshead) Newcastle Central Station Airport:Newcastle Airport Newcastle Airport Attractions:Beamish Wild Beamish Open Air Museum Metro Centre Diggerland |


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Recently nominated for a 2012 IDA Documentary Award for Best Feature and on the roster for the upcoming 2012 AFI Film Festival, The Central Park Five is based on Sarah Burns' best-selling book. In 1989, five black and Latino teens were arrested and charged for brutally raping a white woman in Ce...
Read More »Mr. SOUL!: Ellis Haizlip and the Birth of Black Power TV, the feature length documentary profiling one of the most controversial, successful, and socially significant TV shows in US history, is closing in on its final day of fundraising towards its $75,000 goal.
Read More »Nominations for the 6th annual Cinema Eye Honors will be announced November 2 at an AFI Fest reception at the Roosevelt Hotel. Honoring nonfiction filmmaking, the Cinema Eye Honors will announce ten feature film nominees as well as Outstanding Short Film.
Read More »The Cinema Guild has acquired U.S. distribution rights to Cindy Kleine's documentary "Before and After Dinner: The Life and Work of André Gregory," a portrait of the actor who most famously starred in Louis Malle's "My Dinner with André."
Read More »The International Documentary Association announced their nominees for their 2012 IDA Documentary Awards. It's really exciting to note that 4 of the 5 shorts are directed by women as well as 2 of the 5 features (and one of the other features nominated is The Invisible War).
Read More »From Frank Dawson and Abby Ginzberg, Agents of Change is a feature length documentary that tells the story of "the intersection of race, culture, and the American university."
Read More »It has been almost three years since Josh Fox debuted his anti-fracking documentary "Gasland" at the Sundance Film Festival. There, it caused spirited conversation amongst audiences and won a Special Jury Prize at the festival.
Read More »Katherine Fairfax Wright and Malika Zouhali-Worrall's essential human-rights documentary, "Call Me Kuchu," has gone to Cinedigm for US distribution...
Read More »There's been the little-seen "Charlie Is My Darling" and "Cocksucker Blues," Jean-Luc Godard's "Sympathy for the Devil," 1970's Altamont-focused "Gimme Shelter," Julien Temple's "Stones at the Max" and Martin Scorsese's "Shine a Light," and that's just scratching the surface when it comes to documen...
Read More »Cinedigm Entertainment Group has acquired all U.S. distribution rights to the documentary "Call Me Kuchu." The company plans an early 2013 theatrical run followed by release on digital platforms, DVD and TV.
Read More »


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The Malik Report
A Good Chance The Winter Classic Will Be Cancelled By Friday
by Paul on 10/29/12 at 02:17 PM ET
Comments (10)
from Chris Johnston of the CP at the Globe and Mail,
"While the game may be Jan. 1, I knew that (a decision on the Winter Classic) was coming sooner than people thought," sports marketer Brian Cooper said Monday. "Say you're a bank and you're going to bring down your top 150 wealth management clients and they're going to block off New Year's Day — you have to give that a lot of advance, especially if it's New Year's Day."
Cooper, the president and CEO of S&E Sponsorship Group, represents a number of corporate clients who do business with the NHL.
He views the pending cancellation of the Winter Classic as a significant moment in the league's ongoing labour dispute. The game at Michigan's "Big House" was one he thought had a tremendous amount of potential because of the inclusion of the Maple Leafs, the first Canadian team to participate.
"This is the first year that it really affects Canada," said Cooper. "There was going to be a lot of in-market (sponsorship) activations, there were going to be a lot of hosting opportunities, there were going to be consumer promotions. ...
"This was a big date."
Filed in: | The Malik Report | Permalink
So, am I going to get my ticket service charges back?
Posted by LivinLaVidaLockout on 10/29/12 at 02:49 PM ET
Last I heard from one of Malik reports, no. Go figure.
It'd go a long way towards fan support if the NHL took it upon themselves to do that, though. That'd be good PR, but the NHL will never do this. Having the greatest fans and all.
Posted by HockeytownOverhaul on 10/29/12 at 03:01 PM ET
It would not surprise me if the league jettisoned the Winter Classic sooner rather than later in order to put maximize pressure on the players. If this is truly the last leverage point the players really have over the owners, short of cancelling the entire season, my guess is the league would want that leverage out of the way as soon as feasible.
Posted by timbits on 10/29/12 at 03:20 PM ET
Seems strange that they'd cancel the Winter Classic so soon after canceling November games. I would have expected that they'd wait until at least the second week of November.
Posted by bleep bloop on 10/29/12 at 05:17 PM ET
For those wondering why the NHL would cancel the WC this week, the NYT reported in August the NHL would lose more money if the cancel after Nov. 3rd.
Plus there are logistics involved, moving the ice making equipment, preparing the field for the game, etc.
Posted by Paul from Motown Area on 10/29/12 at 05:22 PM ET
It would not surprise me if the league jettisoned the Winter Classic sooner rather than later in order to put maximize pressure on the players. If this is truly the last leverage point the players really have over the owners, short of cancelling the entire season, my guess is the league would want that leverage out of the way as soon as feasible.
Yep, totally agree.
The NHL makes a load of money at two times. The WC, and the Playoffs. Those are the two points of financial leverage the NHLPA has.
It is not inconceivable that Fehr has been using the lure of WC revenue as a goad to try and work the NHL off their stance. If that's the case, then 'cancelling' the WC pulls those particular teeth.
Although to be clear, if after 'cancelling' the game a deal is struck it's not like the thing can't be resurrected in fairly short order.
Posted by HockeyinHD on 10/29/12 at 05:25 PM ET
For those wondering why the NHL would cancel the WC this week, the NYT reported in August the NHL would lose more money if the cancel after Nov. 3rd.
Only that which UofM tried to pass off as expenses incurred as part of preparations to host the WC.
While I'm sure that UofM could make an argument to nickel-and-dime the NHL, there doesn't seem to be a strong argument that they're really ready to start spending that kind of money they'd expense back to the NHL in the event of a cancellation.
What's further, I'm not quite sure UofM would be too interested in nickel-and-diming the NHL, seeing as how they'd probably be very interested in getting the 2014 WC and the NHL continues to hold all the leverage.
Posted by J.J. from Kansas on 10/29/12 at 05:37 PM ET
Sad day in Hockey.
The hits just keep coming.
Posted by TheRealYooper from within sight of the edge of the Earth. on 10/29/12 at 08:39 PM ET
As Yooper said, the hits keep coming. When I think about the sorely needed revenue that will be lost to S.E. Michigan by the cancellation of these events, not to mention the psychological boost that would have been experienced by sports fans in the area, well, there are no words to describe how I feel about the NHL right now.
Posted by MsRedWinger from GlennieAbbyLand. Now in Flori-Duh. on 10/30/12 at 07:00 AM ET
there are no words to describe how I feel about the NHL right now.
Posted by MsRedWinger from Flori-duh on 10/30/12 at 08:00 AM ET
There are so many words that describe how I feel about the NHL right now but I dare not type them. T'would be much foul language, it would.
Posted by Vladimir16 from Grand River Valley on 10/30/12 at 07:12 AM ET
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Disease Resistance:
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Organic Seeds, Plants, and Supplies For seeds, OG means "organically grown" and signifies seeds harvested from plants grown organically, without synthetic fertilizers or pesticides and according to National Organic Program standards. |
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Pastel pink, round radish.
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Latin Name: Raphanus sativus
Days to Maturity or Bloom: 26
Plant Cycle: (A)
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Growing Information
CULTURE: Radishes require friable, well drained soils with a pH range of 5.8-6.8. Sow at any time during the season, beginning in early spring. Use 2-3" wide bands, seeds about 3/4-1" apart (about 35 seeds/ft. except 10 seeds/ft. for 624 Red Meat and 616 Nero Tondo), 1/2" deep, rows 1' apart, or any row or bedding scheme that will eliminate unplanted ground to discourage weeds. Radishes are adversely affected by hot, dry weather. They remain in prime condition only a few days and should be grown rapidly with plenty of moisture to be mild, tender, and attractive. If growth is checked, roots may become tough, pithy, and too spicy.
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AVG. DIRECT SEEDING RATE: 70'/oz., 14 oz./1,000', 21 lb./acre at 35 seeds/ft. in rows 18" apart, or 31 lb./acre in rows 12" apart.
SIZED SEEDS: Round red varieties only.
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Frank Lloyd Wright House Saved
A rare house from Frank Lloyd Wright's Usonian house period has been saved by the Crystal Bridges Museum in Arkansas. The dramatic rescue plan to disassemble and move the house to a site over 1,000 miles away is required due to frequent flooding of the home's existing site in Millstone, New Jersey. The Crystal Bridges Museum will rebuild and restore the house at a site on their 120-acre grounds.
Read on for more about this unusual preservation
40 Architecture Docs to Watch In 2014
This time last year we published our 30 Architecture Docs to Watch in 2013 featuring a fantastic range of films telling the tales of some of the world's greatest unsung architectural heroes. We now bring you eleven more for 2014, looking past the panoply of stars to bring you more of the best architectural documentaries which will provoke, intrigue and beguile.
A Bad Month for Frank Lloyd Wright Fans
December has been a month of disappointment for fans of Frank Lloyd Wright: first, a plan to build a house designed by Wright and adapted for the English countryside has been rejected by Wraxall Councillors (Bristol Post), who believe that Frank Lloyd Wright "can't be that influential". This was followed by the news that SC Johnson, the company for whom Wright designed the famous Johnson Administration Building, is trying to stop the high profile Sotheby's auction (ArtInfo) of a desk and chair designed for their building – claiming that the items were in fact stolen from them way back in the 1950s. More on the Bristol rejection here and the Sotheby"s controversy here.
Frank Lloyd Wright Building from 1939 Finally Built
54 years after the death of Frank Lloyd Wright, Florida Southern College, home to the largest collection of Frank Lloyd Wright buildings in the world, opened another structure designed by the famed architect last Friday. Originally called the Usonian house, it was envisioned as a professor's home in 1939 but wasn't built until this year using blueprints left by Wright.
Happy 146th Birthday Frank Lloyd Wright
"The greatest American architect of all time", Frank Lloyd Wright, was born 146 years ago today. One of the all-time architectural greats, his work has now been inspiring generations of architects for over a century.
Lloyd Wright is particularly interesting because of the unique period of history which he occupied: as a disciple of Louis Sullivan ('form follows function') in the late 19th century, his work forms something of a bridge between the traditional architecture of that era and the modernists which began to appear around the 1920s. His later work is formally modernist, yet still retains a sensibility rooted in that earlier period.
Frank Lloyd Wright is for many people the quintessential vision of the architect: he presented himself as a lone genius, fastidious down to the smallest details of his design, and his personality was often rather brash; if it weren't for the fact that he was almost always right, he might be seen as arrogant. But there is no denying his vision – and the timelessness of his designs continues to reveal just how strong that vision was.
On the occasion of his birthday, we invite you to take in part of the legacy that Frank Lloyd Wright left behind:
Landmark Preservation Versus Ownership
After years of disconcerting reports that the historic David and Gladys Wright House by Frank Lloyd Wright was under threat of demolition by developers, we announced that a generous benefactor saved it from its fate by providing funds to buy back the property. It seems that this particular story is not unique. An article on ArchRecord by Frank A. Bernstein lists several other modern architecture treasures that may soon fall under the same threat as they hit the real estate market.
Find out more after the break.
The Culture of Landmarks Preservation
Ada Louise Huxtable was a renowned architecture critic who started at The New York Times in 1963. Her probing articles championed the preservation of buildings regarded as examples of historic design still imperative to the life of the city. Her arguments were leveraged by research and an in-depth understanding of architecture as an ever-relevant art form ("the art we cannot afford to ignore"). Alexandra Lange of The Nation points to the connection between Ada Louise Huxtable's writing and its influence on the culture of preservation that eventually resulted in the establishment of the Landmarks Preservation Commission (LPC) in 1965.
More after the break…
Frank Lloyd Wright's Hoffman Auto Showroom Demolished
In late March, one of the few Frank Lloyd Wright designs in New York City was demolished quietly at 430 Park Avenue. This seldom-noticed interior retail space was home to the Hoffman Auto Showroom for over five decades and just as it was considered for preservation by the Landmark Preservation Commission, the owners of the building applied for its demolition. For many people, this may seem like an act of corporate greed or "corporate vandalism" and it may be so, but the landmark designation for interior spaces applies strictly to public space only according to NYC's landmark laws.
So was this space ever anything more than private property? Aside from having been designed by one of America's most famous architects, did the design have "special historical, architectural or cultural significance"?
More after the break…
A Candid Conversation with Frank Lloyd Wright
If you only know Frank Lloyd Wright for his classic works - Fallingwater and the Guggenheim among them – and not for his bristly personality, then you're in for a treat.
WNYC has just released a candid interview they recorded with Wright in 1957, two years before his death, in his Plaza Hotel apartment (where he'd moved to oversee construction of the Guggenheim, which he'd been working on for 14 years). The conversation covers a wide range of topics – from Wright's quirky personal views on American culture to the significance of architecture for mankind. Some gems from the interview include:
On the Guggenheim and its critics: "You're going to be awakened to the beauty of that thing [a picture, a painting] from a new point of view. And it's going to be so enlivening and refreshing, that it will make some of these painters quite ashamed of the protest that they issued against it."
More quotes from Frank Lloyd Wright, after the break…
Films & Architecture: "North by Northwest"
Our latest movie in our Films & Architecture series is another '60s classic, this time by the master filmmaker Alfred Hitchcock. In North by Northwest we see a New York in the heyday of its architectural glory, with one scene taking place at a newly constructed United Nations building. In fact, the last scene takes place in a "house" that, under Hitchcock's instructions, was meant to seem designed by Frank Lloyd Wright (in reality, the house was just another set design). The film shows a variety of urban spaces, and puts special emphasis on the contrast between the densities of urban and rural realms.
As always, enjoy and comment!
Oiio Reveals Proposal for Guggenheim Expansion
With many museums worldwide seeking to extend to accommodate larger collections, Athens-based Oiio Architecture Office has asked: "What if we decided we needed a little more of Guggenheim?"
Their solution is to stretch Frank Lloyd Wright's original building skywards, by continuing its iconic ramp, creating an additional 13 floors.
More on the design after the break…
LEGO® Architecture Landmark Series: The Imperial Hotel
LEGO® aficionados, the wait is over. LEGO® has announced the details of their first edition to the 2013 Architecture series! Who better to kick off the new year than LEGO® Architecture staple Frank Lloyd Wright with his Imperial Hotel in Tokyo.
The most celebrated of Wright's six Japanese buildings, the Imperial Hotel was designed in the, then very chic, Mayan Revival style and constructed largely of stone and reinforced concrete. It was lauded for having survived a sizable earthquake shortly after its opening, however in reality portions of the building sunk leaving residents navigating its wobbly corridors. Eventually it was decided to completely demolish the building in 1968 to make way for the high-rise building that stands on the site today.
But fret not, now instead bemoaning the loss of one of Wright's great works, for between $90-$100, big kids and little architects can reinstate this landmark building on their very own living room floor with 1,188 glossy miniature blocks.
More photos after the break…
Anonymous Benefactor Saves the David and Gladys Wright House
Christmas has come early for the international community of architects and preservationists, as an anonymous benefactor has saved the endangered David and Gladys Wright House in Phoenix, Arizona. Culminating a six month saga, the Frank Lloyd Wright Building Conservancy is proud to announce that it has facilitated the purchase of the historic property through an LLC owned by an anonymous benefactor. The transaction closed today, December 20, and is no longer a demolition threat.
The Wright home will now be transferred to the hands of an Arizona not-for-profit organization responsible for the restoration, maintenance and operation of the structure. The change in ownership guarantees the house will survive and be preserved. Landmark status is expected to follow shortly.
More information on the David Wright House after the break…
Controversial Frank Lloyd Wright-Designed Island For Sale
It turns out the David Wright House isn't the only unusual (and controversial) Frank Lloyd Wright-designed gem on the market.
Petre Island (sometimes called Petra Island) is an 11-acre, heart-shaped island 47 miles from Manhattan. While Wright hand-picked the site himself in 1949, and drew up plans for a 5,000 square foot "dream house" the following year, budget concerns forced him to scale down his vision, resulting in the construction of a smaller guest cottage.
Fast-forward 53 years later, and the island's new owner, John Massaro, decided to make those long-sitting plans reality; he hired architect and Wright scholar Thomas Heinz, who used ArchiCAD to model aspects of Wright's design that weren't obvious from the original renderings and updated the house with some modern amenities.
While the Frank Lloyd Wright Foundation refuses to accept the house as authentic (they even tried to sue Massaro for claiming so), that hasn't stopped AHALife, the web site featuring the island for sale, from proudly selling the "spectacular Frank Lloyd Wright-designed house" for $19,900,000 USD.
More images and info on this Wright-designed island, after the break…
David Wright House Again in Danger of Demolition
Just when we thought the saga was over, a whole new chapter has begun.
The David Wright House, an unusual home in Arizona that Frank Lloyd Wright designed for his son, has been in danger since July, when the developer-owners announced their plans to tear it down and split the lot in two. After considerable hubbub caused by preservationists, and an online petition that received thousands of votes, enough pressure was put on the Pheonix City Council to delay demolition until they could vote on whether or not to confer Landmark Designation on the house (this would delay demolition for another three years, but not safeguard the house from demolition).
However, the point became moot when a preservation-minded buyer swooped in to save the day. Now, just two weeks later, the buyer has backed out.
Find out more on the fate of the David Wright House, after the break…
David Wright Home Sold, (Probably) Saved
After months of following the David Wright House's brushes with demolition, we're happy to report that an anonymous, preservation-friendly buyer has bought the house.
According to Real Estate Agent Robert Joffe, who represented the sellers (the developers who wished to split the Frank Lloyd Wright house down the middle), the new owner intends to preserve and restore the home. It sold for its asking price of $2.38 million dollars.
The Pheonix City Council was slated to vote on the house's landmark designation tomorrow; however, the vote will probably be delayed in light of the sale. As Phoenix City Councilman Sal DiCiccio shared with The Pheonix Business Journal, "The next steps are for me and the Mayor to sit down and get some direction from the purchaser in regards to a long-term vision for the property."
Which is no bad thing – in Pheonix, landmark designation only saves a building for three years. Assuming that the buyer is indeed preservation-minded, the house will be saved for generations to come: the best outcome we could have hoped for for this unusual Wright gem.
Story via The Pheonix Business Journal and The Seattle Times


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The programs are designed to nurture and nourish. Facilitators take participants through activities that have the potential to reduce stress, keep the body and mind healthy, strengthen relationships, maintain a positive attitude to life, and learn about oneself in a new way. These retreats are designed around various themes such as Body, Mind & Soul, Wellbeing, OneFamily, MoveIT, DanceOn, CreativityOn, OnePlanet, SoulFood. Retreats can also be custom-designed for corporates and specific groups.
Auroville Retreat was started in July 2011 to facilitate an exchange between Auroville and the "outside" world. All workshops are facilitated by Aurovilians, giving participants an opportunity to meet and interact with long term Aurovilians. Activities are conducted in various venues in and around Auroville, giving participants a glimpse of life in Auroville.
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Let us entertain you! Vee Quiva Hotel & Casino features world-class entertainment venues that make any night feel like a night on the town. Check out the line up for:
It's all here at VQ. Players Club members get ticket discounts – be sure to sign up! Check back often to see what's coming next.
A multipurpose banquet hall where you can relish a great lineup of entertainment or book your own event. Our 6,000 sq.ft. Event Center is ready to accommodate meetings, receptions and more.
Details >Music comes to life at the West Valley's hottest entertainment venue, featuring signature martinis and an outdoor patio with picturesque views.
Details >Little Joe y La Familia are pioneers of Tejano and Tex-Mex music. With two Grammy Nominations and one Grammy Award Little Joe y La Familia have created a sound that strives to bring people together. In a span of forty years in the music industry the band has released over fifty albums and they continue to break musical barriers and prove why they are the biggest Tex-Mex band in the industry.
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Denny Hamlin driver of the FedEx Express Toyota and Travis Kvapil... News Photo 170699743Brooklyn - Michigan,Burger King,Denny Hamlin,Driver,FedEx Express Toyota,Horizontal,Michigan,Michigan International Speedway,Motorsport,Pepper Toyota,Sport,Sports Race,Sprint Cup Series,Stock Car Racing,Travis Kvapil,USAPhotographer Will SchneeklothCollection: Getty Images Sport 2013 Getty ImagesBROOKLYN, MI - JUNE 16: Denny Hamlin, driver of the #11 FedEx Express Toyota, and Travis Kvapil, driver of the #93 Burger King/Dr. Pepper Toyota, race during the NASCAR Sprint Cup Series Quicken Loans 400 at Michigan International Speedway on June 16, 2013 in Brooklyn, Michigan. (Photo by Will Schneekloth/Getty Images)


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My father Alfred, was William's brother and I remember Uncle Will and Aunt Ina well, together with their family. Joyce I think was the youngest. As children we visited them often at their home in Grangetown. We lived in Southwick. My father married Jane Smithson and had three children, Vera, Alfred and myself Ronald (Ron). Notify Administrator about this message?
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April 21-24, 2015
Woodworking Industry Conference (WIC)
Grand Hyatt San Antonio
San Antonio, TX
May 11-15, 2015
Hannover, Germany
Want to be part of the special WMMA pavilion at LIGNA? Contact Fred Stringfellow at email@example.com.
Posted: 01/26/2015
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Posted: 01/23/2015
Posted: 01/23/2015
Some people are extremely adept at appearing busy when they are actually doing very little productive work.
Posted: 01/23/2015
As the broader housing market continues its sluggish recovery, growth in home improvement spending is also expected to soften throughout the coming year, according to a quarterly forecast by the Remodeling Futures Program at the Joint Center for Housing Studies of Harvard University.
Posted: 01/21/2015
Nominations open for the Baldwin Award
Know an individual who has made significant contributions to the woodworking industry? Nominate them for WMMA's prestigious Baldwin Award. Click here to learn more.
IWF: And the Final Numbers Are...
The final numbers for IWF 2014 are in, and they're nothing short of phenomenal. The total at-show attendance (all days) was 23,463, which broke down as follows:
Attendance (General):
Verified: Advance-Registered: 7,422
Verified: On-site Registered (includes press, speakers, students): 6,915
Unspecified: 63
Total Verified Buyers: 14,400
Exhibiting Personnel: 9,063
Mark your calendar for the next IWF, August 24-27, 2016, and get ready for your own impressive numbers.
Hear what current WMMA members are saying about the valuable benefits and the many rewards of WMMA membership.
ANSI Update
The ANS standard O1.1-3, entitled O1.1-3 (2014) Safety Requirements for CNC Machining Centers for the Woodworking Industry, has been approved by ANSI. As a member company of WMMA, you are entitled to receive one complimentary copy upon request. Email WMMA Associate Director Jennifer Miller at email@example.com to request a copy. Additional copies can be purchased through ANSI at http://webstore.ansi.org/RecordDetail.aspx?sku=ANSI+O1.1-3-2014.
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December 4, 2014
Registration Open for WIC 2015
October 24, 2014
WMMA Celebrates U.S. World Standards Day
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Recently a family member was mistreated by our family physician of more than 15 yrs. The incident involved a stroke caused by undiagnosed hypertension. The trauma our family went through is unspeakable. Not knowing how to handle this, I decided to seek legal advise. Beth came highly recommended as a lawyer that may be able to help. As we presented our case, she listened intently and although she did not make any promises she agreed to review our case. During this last year, Beth has surpassed our expectations! Although compassionate and personable, she has gone above and beyond to seek the truth for my family. Her keen knowdlege of wrongful doings makes her strategy impressive and refreshing! To have her support and belief in our cause is a victory in itself! I must also mention Beth has an incredible staff. Her assistant, Mona, is also very impressive and professional. Mona is kind, very patient, and promptly replies to all my questions. My family feels blessed to have found Beth and to be representated by her organization. Beth and her staff will make you feel good about your cause. My family will always be grateful to her!


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Kodak Cameras
Kodak Halts Camera Production: A Look Back at Its Vintage Beauties
Kodak Halts Camera Production: A Look Back at Its Vintage Beauties
Kodak announced today that it would be halting production of digital cameras, pocket video cameras, and digital picture frames in the first half of this year. The company will instead focus its business on retail-based photo printing and inkjet printers, camera accessories, and batteries, while seeking out licensing partners for future camera products.
Kodak introduced the first digital camera in 1975, but had an impressive lineup of film cameras prior to, and after, that date. We pay tribute to Kodak's legacy here, with a slideshow of our favorite vintage Kodak cameras. Click through the gallery to see more.
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Congratulations to Yvonne Kraker nominated by BizTimes as a Health Care Hero for 2012 in the Nursing category.
Yvonne, Franciscan Villa's Director of Nursing for Assisted Living, started out her career as a missionary in Africa, serving the population there for 17 years. Yvonne and her husband helped to train the village health workers and treated patients with rapid dog bites, snakebites, malaria and even leopard attacks. She returned to the states and sought out a career in long-term care, working with the elderly and Alzheimer's patients.
Yvonne has the patience of a saint and provides excellent nursing to those in her care. She is very compassionate about her job and believes every position in a health care setting is important. "Everybody needs to work together for the benefit of the patients."
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Publications (31)114.14 Total impact
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ABSTRACT: The Na/K pump hydrolyzes ATP to export three intracellular Na (Nai) as it imports two extracellular K (Ko) across animal plasma membranes. Within the protein, two ion-binding sites (sites I and II) can reciprocally bind Na or K, but a third site (site III) exclusively binds Na in a voltage-dependent fashion. In the absence of Nao and Ko, the pump passively imports protons, generating an inward current (IH). To elucidate the mechanisms of IH, we used voltage-clamp techniques to investigate the [H]o, [Na]o, and voltage dependence of IH in Na/K pumps from ventricular myocytes and in ouabain-resistant pumps expressed in Xenopus oocytes. Lowering pHo revealed that Ho both activates IH (in a voltage-dependent manner) and inhibits it (in a voltage-independent manner) by binding to different sites. Nao effects depend on pHo; at pHo where no Ho inhibition is observed, Nao inhibits IH at all concentrations, but when applied at pHo that inhibits pump-mediated current, low [Na]o activates IH and high [Na]o inhibits it. Our results demonstrate that IH is a property inherent to Na/K pumps, not linked to the oocyte expression environment, explains differences in the characteristics of IH previously reported in the literature, and supports a model in which 1), protons leak through site III; 2), binding of two Na or two protons to sites I and II inhibits proton transport; and 3), pumps with mixed Na/proton occupancy of sites I and II remain permeable to protons.Biophysical journal. 06/2014; 106(12):2555-2565. - [Show abstract] [Hide abstract]
ABSTRACT: Schistosomiasis affects over 200 million people worldwide with over 200,000 deaths annually. Currently, praziquantel is the only drug available against schistosomiasis. We report here that Schistosoma mansoni farnesyl diphosphate synthase (SmFPPS) and geranylgeranyl diphosphate synthase (SmGGPPS) are potential drug targets for the treatment of schistosomiasis. We expressed active, recombinant SmFPPS and SmGGPPS for subsequent kinetic characterization and testing against a variety of bisphosphonate inhibitors. Recombinant SmFPPS was found to be a soluble 44.2 kDa protein while SmGGPPS was a 38.3 kDa soluble protein. Characterization of the substrate utilization of the two enzymes indicates that they have overlapping substrate specificities. Against SmFPPS, several bisphosphonates had IC50s in the low micromolar to nanomolar range; these inhibitors had significantly less activity against SmGGPPS. Several lipophilic bisphosphonates were active against ex vivo adult worms with worm death occurring over 4-6 days. These results indicate that FPPS and GGPPS could be of interest in the context of the emerging resistance to praziquantel in schistosomiasis therapy.Antimicrobial Agents and Chemotherapy 09/2013; · 4.57 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Ca(2+)-ATPases are integral membrane proteins that actively transport Ca(2+) against substantial concentration gradients in eukaryotic cells. This active transport is energized by coupling ion translocation with ATP hydrolysis. In order to better understand this coupling mechanism, we studied the nucleotide specificities of isolated ATP binding domains (ABDs) of Solanum lycopersicon Ca(2+)-ATPase (LCA), a type IIA non-calmodulin regulated P-type pump found in tomato plants that is very similar to mammalian sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), and Arabidopsis Ca(2+)-ATPase, isoform 2 (ACA2), a type IIB calmodulin regulated P-type ATPase found in the endoplasmic reticulum of Arabidopsis cells. We used nucleotide protection against FITC labeling as a measure of binding since both LCA and ACA contained the KGAP(S,V,F)E motif, which has been shown to be modified by fluorescein isothiocyanate (FITC) in P-type pumps from animal cells. We demonstrated that the heterologously expressed GST-tagged ABDs from both LCA and ACA2 were modified by FITC and that ATP protects against this modification. Moreover, GTP was able to reduce, but not eliminate, the level of FITC labeling in both ABD constructs, suggesting that these plant pumps may also bind GTP with low affinity, which is in contrast to mammalian SERCA and PMCA type pumps which do not bind GTP.Plant Physiology and Biochemistry 08/2013; 71C:261-267. · 2.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Na,K-ATPase, an integral membrane protein, has been studied for over a half century with respect to its transporter function in the plasma membrane where it expels 3 Na(+) ions from the cell in exchange for two K(+) ions. In this study, we demonstrate a functioning Na,K-ATPase within HEK 293 cell nuclei. This subcellular localization was confirmed by western blotting, ouabain-sensitive ATPase activity of the nuclear membrane fraction, immunocytochemistry, and delivery of fluorescently-tagged Na,K-ATPase α- and β- subunits. In addition, we observed an overlap between nuclear Na,K-ATPase and Na/Ca-exchanger (NCX) when nuclei were immunostained with commercially available Na,K-ATPase and NCX antibodies suggesting a concerted physiological coupling between these transporters. In keeping with this, we observed an ATP-dependent, strophanthidin-sensitive Na(+) flux into the nuclear envelope (NE) lumen loaded with the Na-sensitive dye, CoroNa-Green. Analogous experiments using Fluo-5N, a low affinity Ca(2+) indicator, demonstrated a similar ATP-dependent and strophanthidin-sensitive Ca(2+) flux into the NE lumen. Our results reveal an intracellular physiological role for the coordinated efforts of the Na,K-ATPase and NCX to actively remove Ca(2+) from the nucleoplasm into the NE lumen (i.e. the nucleoplasmic reticulum).Journal of Cell Science 10/2012; · 5.33 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Blocking efficacy of whole soymilk, nonfat soymilk, SuperBlock, and nonfat milk was evaluated by performing standard protein immunoblotting procedures on both purified protein and crude nuclear extracts from HEK 293 cells. Nonfat soymilk was found to have superior blocking efficacy compared with other blocking agents in terms of high signal-to-noise ratio with the shortest blocking times. In addition, the presence of low concentrations of the detergent Tween 20 (0.05-0.1%, v/v) in the wash buffer as well as antibody incubations significantly lessened the background compared with including only the detergent during wash steps.Analytical Biochemistry 04/2012; 426(1):22-3. · 2.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The Na/K pump is a P-type ATPase that exchanges three intracellular Na(+) ions for two extracellular K(+) ions through the plasmalemma of nearly all animal cells. The mechanisms involved in cation selection by the pump's ion-binding sites (site I and site II bind either Na(+) or K(+); site III binds only Na(+)) are poorly understood. We studied cation selectivity by outward-facing sites (high K(+) affinity) of Na/K pumps expressed in Xenopus oocytes, under voltage clamp. Guanidinium(+), methylguanidinium(+), and aminoguanidinium(+) produced two phenomena possibly reflecting actions at site III: (i) voltage-dependent inhibition (VDI) of outwardly directed pump current at saturating K(+), and (ii) induction of pump-mediated, guanidinium-derivative-carried inward current at negative potentials without Na(+) and K(+). In contrast, formamidinium(+) and acetamidinium(+) induced K(+)-like outward currents. Measurement of ouabain-sensitive ATPase activity and radiolabeled cation uptake confirmed that these cations are external K(+) congeners. Molecular dynamics simulations indicate that bound organic cations induce minor distortion of the binding sites. Among tested metals, only Li(+) induced Na(+)-like VDI, whereas all metals tested except Na(+) induced K(+)-like outward currents. Pump-mediated K(+)-like organic cation transport challenges the concept of rigid structural models in which ion specificity at site I and site II arises from a precise and unique arrangement of coordinating ligands. Furthermore, actions by guanidinium(+) derivatives suggest that Na(+) binds to site III in a hydrated form and that the inward current observed without external Na(+) and K(+) represents cation transport when normal occlusion at sites I and II is impaired. These results provide insights on external ion selectivity at the three binding sites.Proceedings of the National Academy of Sciences 10/2010; 107(43):18718-23. · 9.81 Impact Factor - AJP Cell Physiology 08/2010; 299(2):C213-5. · 3.71 Impact Factor
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ABSTRACT: Listeria monocytogenes is a food-borne pathogen that grows at refrigeration temperatures and increases its content of anteiso-C(15:0) fatty acid, which is believed to be a homeoviscous adaptation to ensure membrane fluidity, at these temperatures. As a possible novel approach for control of the growth of the organism, the influences of various fatty acid precursors, including branched-chain amino acids and branched- and straight-chain carboxylic acids, some of which are also well-established food preservatives, on the growth and fatty acid composition of the organism at 37 degrees C and 10 degrees C were studied in order to investigate whether the organism could be made to synthesize fatty acids that would result in impaired growth at low temperatures. The results indicate that the fatty acid composition of L. monocytogenes could be modulated by the feeding of branched-chain amino acid, C(4), C(5), and C(6) branched-chain carboxylic acid, and C(3) and C(4) straight-chain carboxylic acid fatty acid precursors, but the growth-inhibitory effects of several preservatives were independent of effects on fatty acid composition, which were minor in the case of preservatives metabolized via acetyl coenzyme A. The ability of a precursor to modify fatty acid composition was probably a reflection of the substrate specificities of the first enzyme, FabH, in the condensation of primers of fatty acid biosynthesis with malonyl acyl carrier protein.Applied and Environmental Microbiology 03/2010; 76(5):1423-32. · 3.95 Impact Factor - Biophysical Journal 01/2010; 98(3). · 3.83 Impact Factor
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ABSTRACT: Gram-positive bacteria, including Listeria monocytogenes, adjust membrane fluidity by shortening the fatty acid chain length and increasing the proportional production of anteiso fatty acids at lower growth temperatures. The first condensation reaction in fatty acid biosynthesis is carried out by beta-ketoacyl-acyl carrier protein synthase III (FabH), which determines the type of fatty acid produced in bacteria. Here, we measured the initial rates of FabH-catalyzed condensation of malonyl-acyl carrier protein and alternate branched-chain precursor acyl-CoAs utilizing affinity-purified His-tagged L. monocytogenes FabH heterologously expressed in Escherichia coli. Listeria monocytogenes FabH showed a preference for 2-methylbutyryl-CoA, the precursor of odd-numbered anteiso fatty acids, at 30 degrees C, which was further increased at a low temperature (10 degrees C), suggesting that temperature-dependent substrate selectivity of FabH underlies the increased formation of anteiso branched-chain fatty acids during low-temperature adaptation. The increased FabH preferential condensation of 2-methylbutyryl-CoA could not be attributed to a significantly higher availability of this fatty acid precursor as acyl-CoA pool levels were reduced similarly for all fatty acid precursors at low temperatures.FEMS Microbiology Letters 10/2009; 301(2):188-92. · 2.72 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The Na/K pump actively exports 3 Na(+) in exchange for 2 K(+) across the plasmalemma of animal cells. As in other P-type ATPases, pump function is more effective when the relative affinity for transported ions is altered as the ion binding sites alternate between opposite sides of the membrane. Deletion of the five C-terminal residues from the alpha-subunit diminishes internal Na(+) (Na(i)(+)) affinity approximately 25-fold [Morth et al. (2007) Nature 450:1043-1049]. Because external Na(+) (Na(o)(+)) binding is voltage-dependent, we studied the reactions involving this process by using two-electrode and inside-out patch voltage clamp in normal and truncated (DeltaKESYY) Xenopus-alpha1 pumps expressed in oocytes. We observed that DeltaKESYY (i) decreased both Na(o)(+) and Na(i)(+) apparent affinities in the absence of K(o)(+), and (ii) did not affect apparent Na(o)(+) affinity at high K(o)(+). These results support a model of strict sequential external release of Na(+) ions, where the Na(+)-exclusive site releases Na(+) before the sites shared with K(+) and the DeltaKESYY deletion only reduces Na(o)(+) affinity at the shared sites. Moreover, at nonsaturating K(o)(+), DeltaKESYY induced an inward flow of Na(+) through Na/K pumps at negative potentials. Guanidinium(+) can also permeate truncated pumps, whereas N-methyl-D-glucamine cannot. Because guanidinium(o)(+) can also traverse normal Na/K pumps in the absence of both Na(o)(+) and K(o)(+) and can also inhibit Na/K pump currents in a Na(+)-like voltage-dependent manner, we conclude that the normal pathway transited by the first externally released Na(+) is large enough to accommodate guanidinium(+).Proceedings of the National Academy of Sciences 09/2009; 106(36):15507-12. · 9.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The red blood cell membrane is specialized to exchange chloride and bicarbonate; usually the pH gradient, the chloride ratio, and the membrane potential are tightly coupled. We review the evidence that led to the ability to separately vary inside and outside pH in red cells. The effect of pH on Na pump activity and on the selectivity of the inside and the outside transport sites is reviewed. In red blood cells, at high pH, the outside site is not selective. An increase in protons leads to an increase in K(+) affinity, thus making the site more selective. The pK for this site is different in rats and humans; because of the high conservation of residues in these two species, there are only a few possible residues that can account for this difference. On the inside, work from unsided preparations suggests that, at high pH, the transport site is highly selective for Na(+). Once again, an increase in protons leads to an increase in K(+) affinity, but now the result is a less selective site. During their maturation, reticulocytes lose many membrane proteins. The type and fractional loss is species dependent. For example, most reticulocytes lose most of their Na pumps, retaining about 100 pumps per cell, but animals from the order Carnivora lose all their pumps. We review some of the evidence that PKC phosphorylation of N-terminus serines is responsible for endocytosis in other cell types and species variation in this region.Blood Cells Molecules and Diseases 04/2009; 42(3):192-200. · 2.33 Impact Factor -
Article: A tomato ER-type Ca2+-ATPase, LCA1, has a low thapsigargin-sensitivity and can transport manganese.
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ABSTRACT: Recombinant Ca(2+)-ATPase from tomato (i.e. LCA1 for Lycopersicon esculentum [Since the identification and naming of LCA1, the scientific name for the tomato has been changed to Solanum lycopersicum.] Ca-ATPase) was heterologously expressed in yeast for structure-function characterization. We investigate the differences between plant and animal Ca pumps utilizing comparisons between chicken and rabbit SERCA-type pumps with Arabidopsis (ECA1) and tomato plant (LCA1) Ca(2+)-ATPases. Enzyme function was confirmed by the ability of each Ca(2+)-ATPase to rescue K616 growth on EGTA-containing agar and directly via in vitro ATP hydrolysis. We found LCA1 to be approximately 300-fold less sensitive to thapsigargin than animal SERCAs, whereas ECA1 was thapsigargin-resistant. LCA1 showed typical pharmacological sensitivities to cyclopiazonic acid, vanadate, and eosin, consistent with it being a P(IIA)-type Ca(2+)-ATPase. Possible amino acid changes responsible for the reduced plant thapsigargin-sensitivity are discussed. We found that LCA1 also complemented K616 yeast growth in the presence of Mn(2+), consistent with moving Mn(2+) into the secretory pathway and functionally compensating for the lack of secretory pathway Ca-ATPases (SPCAs) in plants.Archives of Biochemistry and Biophysics 12/2008; 481(2):157-68. · 3.04 Impact Factor -
Article: The reactive nitrogen species peroxynitrite is a potent inhibitor of renal Na-K-ATPase activity.
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ABSTRACT: Peroxynitrite is a reactive nitrogen species produced when nitric oxide and superoxide react. In vivo studies suggest that reactive oxygen species and, perhaps, peroxynitrite can influence Na-K-ATPase function. However, the direct effects of peroxynitrite on Na-K-ATPase function remain unknown. We show that a single bolus addition of peroxynitrite inhibited purified renal Na-K-ATPase activity, with IC50 of 107+/-9 microM. To mimic cellular/physiological production of peroxynitrite, a syringe pump was used to slowly release (approximately 0.85 microM/s) peroxynitrite. The inhibition of Na-K-ATPase activity induced by this treatment was similar to that induced by a single bolus addition of equal cumulative concentration. Peroxynitrite produced 3-nitrotyrosine residues on the alpha, beta, and FXYD subunits of the Na pump. Interestingly, the flavonoid epicatechin, which prevented tyrosine nitration, was unable to blunt peroxynitrite-induced ATPase inhibition, suggesting that tyrosine nitration is not required for inhibition. Peroxynitrite led to a decrease in iodoacetamidofluorescein labeling, implying that cysteine modifications were induced. Glutathione was unable to reverse ATPase inhibition. The presence of Na+ and low MgATP during peroxynitrite treatment increased the IC50 to 145+/-10 microM, while the presence of K+ and low MgATP increased the IC50 to 255+/-13 microM. This result suggests that the EPNa conformation of the pump is slightly more sensitive to peroxynitrite than the E(K) conformation. Taken together, these results show that peroxynitrite is a potent inhibitor of Na-K-ATPase activity and that peroxynitrite can induce amino acid modifications to the pump.American journal of physiology. Renal physiology 09/2008; 295(4):F1191-8. · 3.30 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We examined the effect of extracellular terbium (Tb(3+)) and divalent metal cations (Ca(2+), Sr(2+), and Ba(2+)) on (86)Rb(+) influx into rabbit and human red blood cells. We found that Tb(3+) at 15 and 25 microM was a non-competitive inhibitor of (86)Rb(+) influx suggesting that Tb(3+) is not binding to the transport site. This result reduces the usefulness of Tb(3+) as a potential probe for the E(out) conformation (the conformation with the transport site facing extracellularly). Ba(2+), Sr(2+) and Ca(2+), at concentrations >50 mM, had minimal effects on Rb(+) influx into red blood cells (1 mM Rb-out). This suggests that the outside transport site is very specific for monovalent cations over divalent cations, in contrast to the inside transport site. We also found that chrysoidine (4-phenylazo-m-phenylenediamine) competes with Na(+) for ATPase activity and K(+) for pNPPase activity suggesting it is binding to the E(in) conformation. Chrysoidine and similar compounds may be useful as optical probes of the E(in) conformation.Blood Cells Molecules and Diseases 07/2007; 39(1):7-13. · 2.33 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Eosin is a probe for the Na pump nucleotide site. In contrast to previous studies examining eosin effects on Na only ATPase, we examined Na,K-ATPase- and K-activated pNPPase activity in red blood cell membranes and purified renal Na,K-ATPase. At saturating ATP (3 mM) the eosin IC(50) for Na pump inhibition was 19 microM. Increasing ATP concentrations (0.2-2.5 mM) did not overcome eosin-induced inhibition, thus eosin is a mixed-type inhibitor of ATPase activity. To test if eosin can bind to the high-affinity ATP site, purified Na,K-ATPase was labeled with 20 microM FITC. With increasing eosin concentrations (0.1 microM-10 microM) the incorporation of FITC into the ATP site significantly decreases suggesting that eosin prevents FITC reaction at the high-affinity ATP site. Eosin was a more potent inhibitor of K-activated phosphatase activity than of Na,K-ATPase activity. At 5 mM pNPP the eosin IC(50) for Na pump inhibition was 3.8+/-0.23 microM. Increasing pNPP concentrations (0.45-14.5 mM) did not overcome eosin-induced inhibition, thus eosin is a mixed-type inhibitor of pNPPase activity. These results can be fit by a model in which eosin and ATP bind only to the nucleotide site; in some pump conformations, this site is rigid and the binding is mutually exclusive and in other conformations, the site is flexible and able to accommodate both eosin and ATP (or pNPP). Interestingly, eosin inhibition of pNPPase became competitive after the addition of C(12)E(8) (0.1%) but the inhibition of ATPase remained mixed.Blood Cells Molecules and Diseases 05/2007; 38(3):229-37. · 2.33 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The interactions of divalent cations with the adenosine triphosphatase (ATPase) and para-nitrophenyl phosphatase (pNPPase) activity of the purified dog kidney Na pump and the fluorescence of fluorescein isothiocyanate (FITC)-labeled pump were determined. Sr(2+) and Ba(2+) did not compete with K(+) for ATPase (an extracellular K(+) effect). Sr(2+) and Ba(2+) did compete with Na(+) for ATPase (an intracellular Na(+) effect) and with K(+) for pNPPase (an intracellular K(+) effect). These results suggest that Ba(2+) or Sr(2+) can bind to the intracellular transport site, yet neither Ba(2+) nor Sr(2+) was able to activate pNPPase activity; we confirmed that Ca(2+) and Mn(2+) did activate. As another measure of cation binding, we observed that Ca(2+) and Mn(2+), but not Ba(2+), decreased the fluorescence of the FITC-labeled pump; we confirmed that K(+) substantially decreased the fluorescence. Interestingly, Ba(2+) did shift the K(+) dose-response curve. Ethane diamine inhibited Mn(2+) stimulation of pNPPase (as well as K(+) and Mg(2+) stimulation) but did not shift the 50% inhibitory concentration (IC(50)) for the Mn(2+)-induced fluorescence change of FITC, though it did shift the IC(50) for the K(+)-induced change. These results suggest that the Mn(2+)-induced fluorescence change is not due to Mn(2+) binding at the transport site. The drawbacks of models in which Mn(2+) stimulates pNPPase by binding solely to the catalytic site vs. those in which Mn(2+) stimulates by binding to both the catalytic and transport sites are presented. Our results provide new insights into the pNPPase kinetic mechanism as well as how divalent cations interact with the Na pump.Journal of Membrane Biology 04/2007; 216(1):49-59. · 2.17 Impact Factor -
Article: Similarities and differences between organic cation inhibition of the Na,K-ATPase and PMCA.
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ABSTRACT: The effects of three classes of organic cations on the inhibition of the plasma membrane Ca pump (PMCA) were determined and compared to inhibition of the Na pump. Quaternary amines (tetramethylammonium, tetraethylammonium, and tetrapropylammonium, TMA, TEA, and TPA, respectively) did not inhibit PMCA. This is not to imply that PMCA is inherently selective against monovalent cations because guanidine and tetramethylguanidine inhibited PMCA by competing with Ca(2+). The divalent organic cation, ethyl diamine, inhibited PMCA but was not competitive with Ca(2+). In contrast, propyl diamine did compete with Ca(2+) and was about 10-fold more potent than butyl diamine in inhibiting PMCA. For the Na pump, both TEA and TPA inhibited, but TMA did not. TEA, guanidine, and tetramethylguanidine inhibition was competitive with Na(+) for ATPase activation and with K(+) for pNPPase activation, both of which are cytoplasmic substrate cation effects. Thus, these findings are consistent with TEA, guanidine, and tetramethylguanidine inhibiting from the cytoplasmic side of the Na pump; in contrast, we have previously shown that TPA did not inhibit from the cytoplasmic side. The divalent alkane diamines ethyl, propyl, and butyl diamine all inhibited the Na pump and all competed at the intracellular surface. The order of potency was ED > PD > BD consistent with an optimal size for binding; similarly, for the quaternary amines TMA is apparently too small to make appropriate contacts, and TPA is too large. Homology models based upon the high-resolution SERCA structure are included to contextualize the kinetic observations.Biochemistry 11/2006; 45(44):13331-45. · 3.19 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Current models of the Na(+)-K(+)-ATPase reaction cycle have ATP binding with low affinity to the K(+)-occluded form and accelerating K(+) deocclusion, presumably by opening the inside gate. Implicit in this situation is that ATP binds after closing the extracellular gate and thus predicts that ATP binding and extracellular cation binding to be mutually exclusive. We tested this hypothesis. Accordingly, we needed a cation that binds outside and not inside, and we determined that tetrapropylammonium (TPA) behaves as such. TPA competed with K(+) (and not Na(+)) for ATPase, TPA was unable to prevent phosphoenzyme (EP) formation even at low Na(+), and TPA decreased the rate of EP hydrolysis in a K(+)-competitive manner. Having established that TPA binding is a measurement of extracellular access, we next determined that TPA and inorganic phosphate (P(i)) were not mutually exclusive inhibitors of para-nitrophenylphosphatase (pNPPase) activity, implying that when P(i) is bound, the transport site has extracellular access. Surprisingly, we found that ATP and TPA also were not mutually exclusive inhibitors of pNPPase activity, implying that when the cation transport site has extracellular access, ATP can still bind. This is consistent with a model in which ATP speeds up the conformational changes that lead to intracellular or extracellular access, but that ATP binding is not, by itself, the trigger that causes opening of the cation site to the cytoplasm.AJP Cell Physiology 09/2005; 289(2):C302-11. · 3.67 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The quaternary amine, bretylium, is a class III antiarrhythmic drug used to treat ventricular tachycardia and fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. While the Na,K-ATPase has been the pharmacological target of cardiac glycosides for over a century, recent evidence has shown that bretylium may also inhibit the Na pump. Our experimental findings support and extend these previous reports and provide definitive evidence supporting the previous suggestion that bretylium and K compete for the Na pump. We find that bretylium inhibits the Na pump in a dose-dependent manner in both Na,K-ATPase (IC(50) 4.5 mM) and Rb flux experiments (IC(50) 3.5 mM). Furthermore, we show that bretylium and Rb(+) competes for an extracellular site by measuring ouabain-sensitive (86)Rb flux in intact human red blood cells; that is, there is an apparent increase in K(m) for Rb(+) in the presence of 5 mM bretylium, while V(max) remains unchanged. We also determined that unlike K(+), bretylium does not facilitate the hydrolysis of E2-P. However, it stabilizes this conformation by reducing the ability of K(+) to facilitate dephosphorylation. Finally, we show that bretylium, like K(+), reduces [(3)H]ouabain binding to the Na pump. Taken together, these data are consistent with bretylium binding to the extracellular facing cation site within the E2-P state of the enzyme. Moreover, these findings suggest that bretylium may serve as an effective tool for freezing the pump in an extracellularly cation-bound phosphorylated intermediate, which will aid in future structural analyses.Blood Cells Molecules and Diseases 01/2004; 32(3):394-400. · 2.33 Impact Factor
Publication Stats
253 | Citations | |
114.14 | Total Impact Points | |
Top Journals
Illinois State University
- School of Biological Sciences
Normal, Illinois, United States
Texas Tech University Health Sciences Center
- Department of Cell Physiology and Molecular Biophysics
Lubbock, TX, United States
University of Missouri
- Department of Medical Pharmacology and Physiology
Columbia, MO, United States
Oregon Health and Science University
- Department of Biochemistry & Molecular Biology
Portland, OR, United States


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The Royal Spyness series continues with an all-new mystery of "the British monarchy...a wedding in Transylvania...[and] wonderful characters." (#1 New York Times best-selling author Charlaine Harris).
Penniless and 34th in line to the throne, Lady Georgiana Rannoch finds herself in a truly draining state of affairs. To escape her hateful brother, Georgie accepts an invitation from the Queen to represent the royals at a wedding in Transylvania. But at the macabre- looking castle, Georgie finds the bride with blood running down her chin, and a wedding guest is poisoned. Now it's up to Georgie to save the nuptial festivities before the couple's vows become: to love and to cherish, till undeath do them part.
©2010 Janet Quin-Harkin (P)2010 Audible, Inc.
Baltimore book lover
"A little predictable"
I love this series and this book is very good but I took one star off because there is some very cliche vampire stuff. Not a huge part of the book but enough to be just a little distracting. In general though, I love Lady Georgie. There is just enough scene setting to establish a very charming version of Europe in the late 30's and each character is distinct and interesting. The mysteries aren't all that challenging or complicated but I don't mind.
"Rhys Bowen hits another one out of the park!"
If you enjoy a historically based novel, have a background knowledge of the English royal family, enjoy a strong female character, like mysteries, & enjoy twisted humour - then you will love this series. There is a bit of romance, but it doesn't overshadow the storyline. The reader does a great job depicting the cast of characters. Would love to hear more by this author.
"Always good fun"
This is one of the series I thoroughly enjoy and is a new staple for me. Always delivers humorous fun. Very good reader, stories are fluffy but you know that before you buy the book. Entertainment value is solid.
"Performance is key!"
Once more, Katherine Kellgren has done a great job narrating the Royal Spyness series. I love how she's able to provide all the characters with a distinctive voice and her ability to do accents is amazing. I am not too keen about the whole 'vampire' storyline but, overall, it was fun to listen to.
"Bloody good!"
I love the Royal Spyness series! The story is entertaining and extremely well written. The narrator is TOP NOTCH! This series is fun and light.
"Very enjoyable"
This was lots of fun as well as a good puzzle. I am just disappointed that there seem to be only four Royal Blood stories. Since I use audio books as a sleep aid, this book and the rest in the series are perfect for my purposes. They are not so grizzly as to keep me awake, but still keep my interest so that I can hardly wait to get back to listening.
"Love this series!"
I love this series. Katherine Kellgren is my favorite narrator, and the Royal Spyness mysteries are just fun. Can't wait for the next one.
"Light but entertaining"
It is a very light mystery story but I found it entertaining. I will look for other books narrated by Katherine Kellgren, I enjoyed her performance.
"Royal Blood is Bloody Good"
I was surprised at who-dun-it...
Katherine is a wonderful reader...Coco
All these books are great pot boilers
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2 Broke Girls
2 BROKE GIRLS is a comedy about two young women waitressing at a greasy spoon diner who strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
2 BROKE GIRLS is a comedy about two young women waitressing at a greasy spoon diner who strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
8tracks is handcrafted internet radio. It offers a simple way for people to share and discover music through an online mix, a short playlist containing at least 8 tracks.
BIO is about real people who have extraordinary experiences in their real lives. We are up-close and personal, emotional, gritty and provocative, always unfiltered. BIO is about compelling, first person storytelling.
Break.com is the premier online entertainment destination with videos, picture galleries, Girls of the Day, games, and more. Break is more than a website - we are a cutting edge community for guys and the content they want to see. Break is populated with videos made by and hilarious original content we create. We know what guys want to see because we want to see it, too.
We talk about sports, sports, and well ... sports.
HISTORY is the leading destination for revealing, award-winning original non-fiction series and event-driven specials that connect history with viewers in an informative, immersive and entertaining manner across multiple platforms.
Hulu is an online video service that offers hit TV shows, feature films, and clips anytime in the US. Our mission is to help people find and enjoy the world's premium video content when, where and how they want it.
The first word on how technology is changing our world.
For the last 50 years our mission has been to stop the degradation of the planet's natural environment and to build a future in which humans live in harmony with nature.
We make funny videos with famous people. Will Ferrell is our boss. We like to laugh and watch kittens do adorable people things.
Burger Junkies is a burger review blog where you can read about the best burger reviews and witness some beautiful burger photography. Each burger is photographed, reviewed and rated on the 5 point BurgerJunkies Rating Scale that focuses on the 5 factors that make up a perfect burger.
Adult Swim is all up in your Internet. Why busy yourself being productive when you could be watching videos and clips from shows like Aqua Unit Patrol Squad 1, Family Guy, and Childrens Hospital? And if our shows don't scratch your itch, maybe you'd prefer galloping across a rainbow dreamscape or harvesting some industrial hemp? Robot Unicorn Attack and Hemp Tycoon are just two of the countless games we have waiting for you in our online amusement park. In between watching videos and playing games, you can read interviews with celebrities like Robot Chicken's Seth Green and porn star Joanna Angel. And don't miss our funny lists, weird links, music videos, bizarre tangents and other distractions of questionable value. It's like a treasure trove of digital doubloons. Rest assured; Adult Swim is taking this Internet thing very seriously.
Cosmopolitan is the channel for millions of fun, fearless females who want to be the best they can be in every area of their lives.


text: JANUARY, 2015 Exercise DVD The exercise DVD, Keep Moving with Alta Mae, can be ordered by clicking here. The cost is $15 per DVD. Click here to see a youtube video about the DVD. Free exercise class: Every Tuesday & Thursday at 10:00 A.M. at Ridgeway Baptist Church, Christian Life Center, 2500 Ridgeway Road, Memphis; led by Alta Mae Allison. 2nd Tuesday Lunch Bunch: Starting in 2015, the Lunch Bunch will meet on Tuesdays of each month. The Lunch Bunch will meet this month on Tuesday, January 13, 2015 at 11:30 A.M. at Owen Brennan's, 6150 Poplar Avenue, Memphis, TN. 4th Tuesday Regular meeting: The meeting will be held on Tuesday, January 27, 2015 at 2:00 P.M. in the Parish Hall at St. John's Episcopal Church, 3245 Central at Greer (Please enter through the door on Greer). The speaker this month will be Dr. Mark LeDoux, Neurologist and Movement Disorder Specialist sponsored by TEVA Pharmaceuticals. The topic is to be announced at a later date. Annual dues: Beginning in 2015, the Support Group annual dues will be $20 per family per year. Please mail your 2015 annual dues of $20 per family to the Mid-South PD Support Group, 198 Tuckahoe Lane, Memphis, TN 38117. You can also give it to Ann Pate at the next meeting. If you are paying in cash, please put your payment in an envelope with your name on it. |


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Lil Wayne's Trukfit Collection: The Martian Launches a Label That's Skate Boy Fresh
Endorse (From VIBE's April/May 2012 Issue)
Lil Wayne's Trukfit Collection
The Martian launches a label that's skate boy fresh --Mikey Fresh
VIBE: Rapper clothing lines were popping at one point, but then fizzled. What made you start one now?
Lil Wayne: I always had a clothing line. I never had the proper time, the proper name and never was really into it. It's probably been two or three years now, just never put it out. I was never satisfied with the design.
Many of the pieces are very skateboard influenced.
Yeah, it was just a natural thing. It represents where I'm at and what I'm about right now.
Who were some of your initial inspirations?
Just speaking to some of my homies that have clothing lines—Stevie Williams from DGK [Dirty Ghetto Kids], people like that.
Do you plan on expanding into jeans and accessories?
We're going to get into all that. I just have to approve everything. I approve all products and I'm a very strict, unreasonable guy. That's really the holdup on a lot of things.
Where do you envision Trukfit going—on the level of Gucci or Polo?
That's the beautiful part of it. I don't have a destination. Therefore, it can go wherever and I'll be excited about it.
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January 2012 Issue
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