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Politics is a blood sport, and it's naive to think there won't be some serious injuries when playing in the political big leagues. Because the stakes are so high, people running for office put forth enormous efforts to scrub their past and curricula vitae of any information that could give the faintest whiff of scandal or irregularity. This leads to many self-inflicted wounds. Excessive fear of scrutiny breeds secrecy, which can inspire conspiracy theories, as the current occupant of the White House has proven.
All of the question marks lurking around President Obama's background could be answered with a little transparency. Fair or not, refusing to make college transcripts public makes a gossipy society curious about what someone has to hide. When a public servant doesn't provide clarity, the creative masses will fill in the blanks. As liberal MSNBC host Chris Matthews frustratingly asked about the hullabaloo over Mr. Obama's birth certificate, "Why doesn't the president just say, 'Send me a copy right now?' Why doesn't [White House spokesman Robert L.] Gibbs and [presidential Senior Adviser David M.] Axelrod say, 'Let's just get this crappy story dead?' Why not do it? If it exists, why not put it out?"
Democrats try to wave off the birther controversy as a right-wing tempest in a teapot, but the president, his own staff and backers are the rainmakers who have stirred the recent storm. Even when conservative critics of this administration try to ignore the numerous conspiracy theories flying around Mr. Obama, Democrats like Mr. Matthews keep bringing the issues to the fore and thus make the scandals more bipartisan and mainstream. Hawaii Democrat Neil Abercrombie - a left-winger who made his political debut in 1970 as a longhaired Vietnam war protester - is another example. After being elected governor in November, Mr. Abercrombie, an Obama supporter, vowed to put the birther issue to rest "as quick as we can" because it could have implications for the 2012 presidential race. Now he's backtracking and giving conflicting statements about what exists and what doesn't. With friends like these, the president hardly needs enemies.
The whole saga is tawdry. Like the constant drip of lurid revelations about Bill Clinton's adulterous affairs, it'd be nice if the smarminess all went away. There are enough substantive policy issues to fight this president over besides worrying about whether little Barry was born in Honolulu or Hartford or Havana. (Free scoop to the blogosphere: Check the Cuban archives.) The fact of the matter is this president gets treated with extra-sensitive kid gloves for fear of trampling on pseudo-sacred politically correct ground. For instance, many newspapers like this one typically use middle initials with names of public officials but don't for Barack Obama. Even though the White House's own website makes use of the presidential "H," which is short for Hussein, I don't on these pages to avoid distracting charges of Islamophobia or racism or just being mean to the historic first mixed-race president of the United States. Political correctness engenders self-censorship, even here.
A lot of Mr. Obama's problems can be chalked up to bad public-relations practices and incompetent crisis management. From major mistakes such as America throwing Egyptian President Hosni Mubarak under the bus to more run-of-the mill stories like the first family's constant expensive vacations on the taxpayers' dime, this president is being poorly served by his handlers. Check out the contradictory statements about Cairo from the White House and the State Department and it's hard to come to any conclusion other than that it's amateur hour in this administration. Drama engulfs everything these people do. At the end of the day, it's a head-scratcher: Why does everything about this guy have to be so weird? Why can't Barack be a little more normal?
The holdup is that this particular politician is not a transparent person. As a candidate and as president, Mr. Obama has been so stage-managed that it's not easy to know who the heck the guy really is, and his own aides get tangled up trying to decide what's true and what's spin. "Deconstructing Obama," a new book by Jack Cashill, pulls back the velvet curtain to give a glimpse backstage. His purpose is to provide an expose on a politician who has gone to great lengths to carefully manufacture a narrative for his whole life that is appealing for public consumption. There's often a difference between what's true and what sells, and Mr. Obama is a salesman. The product he's peddling is himself, so there's a need to know some of the other side of the story. "If the role of the postmodern writer is to construct a reality, the role of the postmodern critic is thus to 'deconstruct' it," the author explains.
The image of Mr. Obama is such an artificial construct that it's necessary to deconstruct some of the artifice. That work is not character assassination; it's how the game is played in the rough and tumble of Washington.
Brett M. Decker is editorial page editor of The Washington Times.
© Copyright 2015 The Washington Times, LLC. Click here for reprint permission.


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Publications (26)209.29 Total impact
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ABSTRACT: Emergence of bacterial resistance is a major issue for all classes of antibiotics; therefore, the identification of new classes is critically needed. Recently we reported the discovery of platensimycin by screening natural product extracts using a target-based whole-cell strategy with antisense silencing technology in concert with cell free biochemical validations. Continued screening efforts led to the discovery of platencin, a novel natural product that is chemically and biologically related but different from platensimycin. Platencin exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis. It does not exhibit cross-resistance to key antibiotic resistant strains tested, including methicillin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. Platencin shows potent in vivo efficacy without any observed toxicity. It targets two essential proteins, beta-ketoacyl-[acyl carrier protein (ACP)] synthase II (FabF) and III (FabH) with IC50 values of 1.95 and 3.91 microg/ml, respectively, whereas platensimycin targets only FabF (IC50 = 0.13 microg/ml) in S. aureus, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.Proceedings of the National Academy of Sciences 06/2007; 104(18):7612-6. · 9.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Bacterial infection remains a serious threat to human lives because of emerging resistance to existing antibiotics. Although the scientific community has avidly pursued the discovery of new antibiotics that interact with new targets, these efforts have met with limited success since the early 1960s. Here we report the discovery of platensimycin, a previously unknown class of antibiotics produced by Streptomyces platensis. Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis. We show that this anti-bacterial effect is exerted through the selective targeting of beta-ketoacyl-(acyl-carrier-protein (ACP)) synthase I/II (FabF/B) in the synthetic pathway of fatty acids. Direct binding assays show that platensimycin interacts specifically with the acyl-enzyme intermediate of the target protein, and X-ray crystallographic studies reveal that a specific conformational change that occurs on acylation must take place before the inhibitor can bind. Treatment with platensimycin eradicates Staphylococcus aureus infection in mice. Because of its unique mode of action, platensimycin shows no cross-resistance to other key antibiotic-resistant strains tested, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus and vancomycin-resistant enterococci. Platensimycin is the most potent inhibitor reported for the FabF/B condensing enzymes, and is the only inhibitor of these targets that shows broad-spectrum activity, in vivo efficacy and no observed toxicity.Nature 06/2006; 441(7091):358-61. · 42.35 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Condensing enzymes are essential in type II fatty acid synthesis and are promising targets for antibacterial drug discovery. Recently, a new approach using a xylose-inducible plasmid to express antisense RNA in Staphylococcus aureus has been described; however, the actual mechanism was not delineated. In this paper, the mechanism of decreased target protein production by expression of antisense RNA was investigated using Northern blotting. This revealed that the antisense RNA acts posttranscriptionally by targeting mRNA, leading to 5' mRNA degradation. Using this technology, a two-plate assay was developed in order to identify FabF/FabH target-specific cell-permeable inhibitors by screening of natural product extracts. Over 250,000 natural product fermentation broths were screened and then confirmed in biochemical assays, yielding a hit rate of 0.1%. All known natural product FabH and FabF inhibitors, including cerulenin, thiolactomycin, thiotetromycin, and Tü3010, were discovered using this whole-cell mechanism-based screening approach. Phomallenic acids, which are new inhibitors of FabF, were also discovered. These new inhibitors exhibited target selectivity in the gel elongation assay and in the whole-cell-based two-plate assay. Phomallenic acid C showed good antibacterial activity, about 20-fold better than that of thiolactomycin and cerulenin, against S. aureus. It exhibited a spectrum of antibacterial activity against clinically important pathogens including methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Haemophilus influenzae.Antimicrobial Agents and Chemotherapy 03/2006; 50(2):519-26. · 4.45 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Invertebrate glutamate-gated chloride channels (GluCls) are important targets for anthelmintics and insecticides such as ivermectin. To facilitate screening for novel GluCl modulators, the Caenorhabditis elegans GluCl alpha2beta channel was chosen as a surrogate for parasite channels not yet cloned, and an inducible stable human embryonic kidney cell line was generated. Functional expression of the alpha2 and beta subunits was confirmed by whole-cell voltage clamp assays. Using this cell line, a high-throughput assay was developed that detects membrane potential changes associated with the activation of GluCls. In this assay, membrane depolarization was quantified via changes in fluorescence resonance energy transfer between two membrane-associated dyes. Robust and reproducible signals were detected in response to addition of glutamate or ivermectin. This assay was used for the screening of over 180,000 samples from natural and synthetic sources.Assay and Drug Development Technologies 03/2005; 3(1):59-64. · 2.08 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. In the past decade, a few inhibitors have been identified for this pathway, but none of them lend themselves to drug development. To find better inhibitors that are potential drug candidates, we developed a high throughput assay that identifies inhibitors simultaneously against multiple targets within the FASII pathway of most bacterial pathogens. We demonstrated that the inverse t(1/2) value of the FASII enzyme-catalyzed reaction gives a measure of FASII activity. The Km values of octanoyl-CoA and lauroyl-CoA were determined to be 1.1 +/- 0.3 and 10 +/- 2.7 microM in Staphylococcus aureus and Bacillus subtilis, respectively. The effects of free metals and reducing agents on enzyme activity showed an inhibition hierarchy of Zn2+ > Ca2+ > Mn2+ > Mg2+; no inhibition was found with beta-mercaptoethanol or dithiothreitol. We used this assay to screen the natural product libraries and isolated an inhibitor, bischloroanthrabenzoxocinone (BABX) with a new structure. BABX showed IC50 values of 11.4 and 35.3 microg/ml in the S. aureus and Escherichia coli FASII assays, respectively, and good antibacterial activities against S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2 to 0.4 microg/ml. Furthermore, the effectiveness, selectivity, and the in vitro and in vivo correlations of BABX as well as other fatty acid inhibitors were elucidated, which will aid in future drug discovery.Journal of Biological Chemistry 02/2005; 280(2):1669-77. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The emergence of bacterial resistance to antibiotics is a major health problem and, therefore, it is critical to develop new antibiotics with novel modes of action. FtsZ, a tubulin-like GTPase, plays an essential role in bacterial cell division, and its homologs are present in almost all eubacteria and archaea. During cell division, FtsZ forms polymers in the presence of GTP that recruit other division proteins to make the cell division apparatus. Therefore, inhibition of FtsZ polymerization will prevent cells from dividing, leading to cell death. Using a fluorescent FtsZ polymerization assay, the screening of >100,000 extracts of microbial fermentation broths and plants followed by fractionation led to the identification of viriditoxin, which blocked FtsZ polymerization with an IC50 of 8.2 microg/ml and concomitant GTPase inhibition with an IC50 of 7.0 microg/ml. That the mode of antibacterial action of viriditoxin is via inhibition of FtsZ was confirmed by the observation of its effects on cell morphology, macromolecular synthesis, DNA-damage response, and increased minimum inhibitory concentration as a result of an increase in the expression of the FtsZ protein. Viriditoxin exhibited broad-spectrum antibacterial activity against clinically relevant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci, without affecting the viability of eukaryotic cells.Journal of Biological Chemistry 11/2003; 278(45):44424-8. · 4.60 Impact Factor -
Article: RdlDv, a novel GABA-gated chloride channel gene from the American dog tick Dermacentor variabilis.
[Show abstract] [Hide abstract]
ABSTRACT: The American dog tick Dermacentor variabilis is a major transmitter of bacterial and viral pathogens in human and animal populations, and compounds active against this species would benefit both human and animal health. Invertebrate GABA-gated chloride channels are validated targets of commonly used insecticides and acaricides. We cloned a novel member of the invertebrate GABA-gated chloride channel gene family from Dermacentor variabilis, RdlDv. The closest homologue of the predicted gene product of RdlDv is the RDL protein encoded by the GABA-gated chloride channel gene Drosophila Rdl (Resistance to Dieldrin), with which it shares 64% amino acid identity. When expressed in Xenopus oocytes, RdlDv produces GABA-activated currents blocked by the known insecticides and RDL antagonists fipronil and picrotoxinin. These results suggest that RdlDv encodes a GABA-gated chloride channel subunit, making it a potential target for compounds active against the tick D. variabilis.Insect Biochemistry and Molecular Biology 07/2003; 33(6):595-9. · 3.42 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: 35S-labeled derivatives of the insecticides nodulisporic acid and ivermectin were synthesized and demonstrated to bind with high affinity to a population of receptors in Drosophila head membranes that were previously shown to be associated with a glutamate-gated chloride channel. Nodulisporic acid binding was modeled as binding to a single population of receptors. Ivermectin binding was composed of at least two kinetically distinct receptor populations, only one of which was associated with nodulisporic acid binding. The binding of these two ligands was modulated by glutamate, ivermectin, and antagonists of invertebrate gamma-aminobutyric acid (GABA)ergic receptors. Because solubilized nodulisporic acid and ivermectin receptors comigrated as 230-kDa complexes by gel filtration, antisera specific for both the Drosophila glutamate-gated chloride channel subunit GluCl alpha (DmGluCl alpha) and the GABA-gated chloride channel subunit Rdl (DmRdl) proteins were generated and used to examine the possible coassembly of these two subunits within a single receptor complex. DmGluCl alpha antibodies immunoprecipitated all of the ivermectin and nodulisporic acid receptors solubilized by detergent from Drosophila head membranes. DmRdl antibodies also immunoprecipitated all solubilized nodulisporic receptors, but only approximately 70% of the ivermectin receptors. These data suggest that both DmGluCl alpha and DmRdl are components of nodulisporic acid and ivermectin receptors, and that there also exists a distinct class of ivermectin receptors that contains the DmGluCl alpha subunit but not the DmRdl subunit. This co-association of DmGluCl alpha and DmRdl represents the first biochemical and immunological evidence of coassembly of subunits from two different subclasses of ligand-gated ion channel subunits.Biochemistry 06/2002; 41(20):6548-60. · 3.19 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Histamine has been shown to play a role in arthropod vision; it is the major neurotransmitter of arthropod photoreceptors. Histamine-gated chloride channels have been identified in insect optic lobes. We report the first isolation of cDNA clones encoding histamine-gated chloride channel subunits from the fruit fly Drosophila melanogaster. The encoded proteins, HisCl1 and HisCl2, share 60% amino acid identity with each other. The closest structural homologue is the human glycine alpha3 receptor, which shares 45 and 43% amino acid identity respectively. Northern hybridization analysis suggested that hisCl1 and hisCl2 mRNAs are predominantly expressed in the insect eye. Oocytes injected with in vitro transcribed RNA, encoding either HisCl1 or HisCl2, produced substantial chloride currents in response to histamine but not in response to GABA, glycine, and glutamate. The histamine sensitivity was similar to that observed in insect laminar neurons. Histamine-activated currents were not blocked by picrotoxinin, fipronil, strychnine, or the H2 antagonist cimetidine. Co-injection of both hisCl1 and hisCl2 RNAs resulted in expression of a histamine-gated chloride channel with increased sensitivity to histamine, demonstrating coassembly of the subunits. The insecticide ivermectin reversibly activated homomeric HisCl1 channels and, more potently, HisCl1 and HisCl2 heteromeric channels.Journal of Biological Chemistry 02/2002; 277(3):2000-5. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The fruit fly Drosophila melanogaster was used to examine the mode of action of the novel insecticide and acaricide nodulisporic acid. Flies resistant to nodulisporic acid were selected by stepwise increasing the dose of drug in the culture media. The resistant strain, glc(1), is at least 20-fold resistant to nodulisporic acid and 3-fold cross-resistant to the parasiticide ivermectin, and exhibited decreased brood size, decreased locomotion, and bang sensitivity. Binding assays using glc(1) head membranes showed a marked decrease in the affinity for nodulisporic acid and ivermectin. A combination of genetics and sequencing identified a proline to serine mutation (P299S) in the gene coding for the glutamate-gated chloride channel subunit DmGluClalpha. To examine the effect of this mutation on the biophysical properties of DmGluClalpha channels, it was introduced into a recombinant DmGluClalpha, and RNA encoding wild-type and mutant subunits was injected into Xenopus oocytes. Nodulisporic acid directly activated wild-type and mutant DmGluClalpha channels. However, mutant channels were approximately 10-fold less sensitive to activation by nodulisporic acid, as well as ivermectin and the endogenous ligand glutamate, providing direct evidence that nodulisporic acid and ivermectin act on DmGluClalpha channels.Proceedings of the National Academy of Sciences 01/2001; 97(25):13949-54. · 9.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A glow-type aequorin luminescence assay for measuring receptor-mediated stimulation of intracellular calcium levels is described and characterized. The human 5-hydroxytryptamine(2A) receptor stably coexpressed in human embryonic kidney cells with apoaequorin was used to characterize the system and showed that following the flash reaction, a stable luminescence signal could be measured using a microplate scintillation counter for between 3 and 7 h after the addition of receptor agonist. Furthermore, this luminescence was dependent on the concentration of agonist used and gave potency values that were stable over this time period. Testing a range of 5-hydroxytryptamine(2A) receptor agonists gave the expected rank order of potency for this receptor. The glow luminescence could also be inhibited by 5-hydroxytryptamine(2A) receptor antagonists, generating affinity values that directly correlated with those determined for inhibition of the flash reaction carried out under the same buffer conditions. The assay therefore gave pharmacologically relevant data and allows a significant improvement of throughput over the traditional flash-type measurements made using an injecting luminometer.Analytical Biochemistry 12/2000; 286(2):231-7. · 2.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A convenient functional assay for 5HT2a and 5HT2c receptors is reported utilizing the bioluminescent aequorin to detect intracellular calcium changes. Using this assay, the pharmacological properties of many 5HT ligands can be determined in a 96-well format. The data indicate that the aequorin detection method is superior to the inositol phosphate assay with regard to speed and scope. This system is also appropriate for kinetic studies of receptor desensitization. We showed that the human 5HT2c receptor desensitizes in a biphasic manner, with a fast desensitization of approximately 90% of the total response occurring within 15 minutes while the remaining 10% response remains for at least 3 hours.Journal of Receptor and Signal Transduction Research 12/1999; 19(6):927-38. · 1.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Glutamate-gated chloride channels have been described in nematodes, insects, crustaceans, and mollusks. Subunits from the nematode and insect channels have been cloned and are phylogenetically related to the GABA and glycine ligand-gated chloride channels. Ligand-gated chloride channels are blocked with variable potency by the nonselective blocker picrotoxin. The first two subunits of the glutamate-gated chloride channel family, GluClalpha and GluClbeta, were cloned from the free living nematode Caenorhabditis elegans. In this study, we analyze the blockade of these novel channels by picrotoxin. In vitro synthesized GluClalpha and GluClbeta RNAs were injected individually or coinjected into Xenopus oocytes. The EC50 values for picrotoxin block of homomeric GluClalpha and GluClbeta were 59 microM and 77 nM, respectively. Picrotoxin block of homomeric GluClbeta channels was promoted during activation of membrane current with glutamate. In addition, recovery from picrotoxin block was faster during current activation by glutamate. A chimeric channel between the N-terminal extracellular domain of GluClalpha and the C-terminal membrane-spanning domain of GluClbeta localized the higher affinity picrotoxin binding site to the membrane-spanning domains of GluClbeta. A point mutation within the M2 membrane-spanning domain of GluClbeta reduced picrotoxin sensitivity >10,000-fold. We conclude that picrotoxin blocks GluCl channels by binding to a site accessible when the channel is open.Journal of Neurochemistry 01/1999; 72(1):318-26. · 4.24 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: At present, leptin is quantitated using immuno-assays that measure leptin mass. Leptin biological activity is determined using protocols that measure feed consumption and weight reduction. These in vivo protocols are semi-quantitative and require large quantities of leptin. We describe a rapid, sensitive and quantitative in vitro assay for leptin using HEK-293 cells stably co-transfected with the leptin receptor Ob-Rb isoform and a STAT-inducible promoter regulating the firefly luciferase cDNA. The assay, performed in a 96-well format, has an EC50 of 150 pM and is linear from 3 to 700 pM of leptin. We demonstrate that the assay is capable of measuring leptin in plasma samples. We demonstrate that bacterially-expressed, recombinant leptin and in vivo expressed leptin are equipotent. Furthermore, we demonstrate that a leptin-derived peptide, leptin fragment 22-56, previously shown to be capable of reducing feed intake following ICV injection does not act directly through the leptin receptor.Molecular and Cellular Endocrinology 09/1998; 143(1-2):117-23. · 4.24 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Avermectins are a class of macrocyclic lactones that is widely used in crop protection and to treat helminth infections in man and animals. Two complementary DNAs (GluClalpha and GluClbeta) encoding chloride channels that are gated by avermectin and glutamate, respectively, were isolated from Caenorhabditis elegans. To study the role of these subunits in conferring avermectin sensitivity we isolated a mutant C. elegans strain with a Tc1 transposable element insertion that functionally inactivated the GluClalpha gene (GluClalpha::Tc1). GluClalpha::Tc1 animals exhibit a normal phenotype including typical avermectin sensitivity. Xenopus oocytes expressing GluClalpha::Tc1 strain mRNA elicited reduced amplitude avermectin and glutamate-dependent chloride currents. Avermectin binding assays in GluClalpha::Tc1 strain membranes showed the presence of high affinity binding sites, with a reduced Bmax. These experiments suggest that GluClalpha is a target for avermectin and that additional glutamate-gated and avermectin-sensitive chloride channel subunits exist in C. elegans. We isolated a cDNA (GluClalpha2) encoding a chloride channel that shares 75% amino acid identity with GluClalpha. This subunit forms homomeric channels that are gated irreversibly by avermectin and reversibly by glutamate. GluClalpha2 coassembles with GluClbeta to form heteromeric channels that are gated by both ligands. The presence of subunits related to GluClalpha may explain the low level and rarity of target site involvement in resistance to the avermectin class of compounds.Journal of Biological Chemistry 01/1998; 272(52):33167-74. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Two cDNAs, GluClalpha and GluClbeta, encoding glutamate-gated chloride channel subunits that represent targets of the avermectin class of antiparasitic compounds, have recently been cloned from Caenorhabditis elegans (Cully et al., Nature, 371, 707-711, 1994). Expression studies in Xenopus oocytes showed that GluClalpha and GluClbeta have pharmacological profiles distinct from the glutamate-gated cation channels as well as the gamma-aminobutyric acid (GABA)- and glycine-gated chloride channels. Establishing the evolutionary relationship of related proteins can clarify properties and lead to predictions about their structure and function. We have cloned and determined the nucleotide sequence of the GluClalpha and GluClbeta genes. In an attempt to understand the evolutionary relationship of these channels with the members of the ligand-gated ion channel superfamily, we have performed gene structure comparisons and phylogenetic analyses of their nucleotide and predicted amino acid sequences. Gene structure comparisons reveal the presence of several intron positions that are not found in the ligand-gated ion channel superfamily, outlining their distinct evolutionary position. Phylogenetic analyses indicate that GluClalpha and GluClbeta form a monophyletic subbranch in the ligand-gated ion channel superfamily and are related to vertebrate glycine channels/receptors. Glutamate-gated chloride channels, with electrophysiological properties similar to GluClalpha and GluClbeta, have been described in insects and crustaceans, suggesting that the glutamate-gated chloride channel family may be conserved in other invertebrate species. The gene structure and phylogenetic analyses in combination with the distinct pharmacological properties demonstrate that GluClalpha and GluClbeta belong to a discrete ligand-gated ion channel family that may represent genes orthologous to the vertebrate glycine channels.Journal of Molecular Evolution 06/1997; 44(5):501-8. · 1.86 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The leptin receptor (OB-R) bears homology to members of the class I cytokine receptor family. We demonstrate that leptin binding to OB-R stimulates formation of STAT-1 and STAT-3 complexes, thereby defining transcriptional motifs for genes that are under leptin control. Transfected fa OB-R bound leptin with equal affinity to that of wild type OB-R. fa OB-R abundance was about 7 fold reduced compared to control cells. Surprisingly, the low level of fa OB-R is fully capable of activating the STAT signal transduction pathway. We discuss plausible explanations for the obese phenotype in Zucker fatty rats.Endocrinology 12/1996; 137(11):5178-81. · 4.64 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Glutamate-gated chloride channels, members of the ligand-gated ion channel superfamily, have been shown in nematodes and in insects to be a target of the antiparasitic agent avermectin. Two subunits of the Caenorhabditis elegans glutamate-gated chloride channel have been cloned: GluCl-alpha and GluCl-beta. We report the cloning of a Drosophila melanogaster glutamate-gated chloride channel, DrosGluCl-alpha, which shares 48% amino acid and 60% nucleotide identity with the C. elegans GluCl channels. Expression of DrosGluCl-alpha in Xenopus oocytes produces a homomeric chloride channel that is gated by both glutamate and avermectin. The DrosGluCl-alpha channel has several unique characteristics not observed in C. elegans GluCl: dual gating by avermectin and glutamate, a rapidly desensitizing glutamate response, and a lack of potentiation of the glutamate response by avermectin. The pharmacological data support the hypothesis that the DrosGluCl-alpha channel represents the arthropod H-receptor and an important target for the avermectin class of insecticides.Journal of Biological Chemistry 09/1996; 271(33):20187-91. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.Science 09/1996; 273(5277):974-7. · 31.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Many of the subunits of ligand-gated ion channels respond poorly, if at all, when expressed as homomeric channels in Xenopus oocytes. This lack of a ligand response has been thought to result from poor surface expression, poor assembly, or lack of an agonist binding domain. The Caenorhabditis elegans glutamate-gated chloride channel subunit GluClbeta responds to glutamate as a homomeric channel while the GluClalpha subunit is insensitive. A chimera between GluClalpha and GluClbeta was used to suggest that major determinants for glutamate binding are present on the GluClalpha N terminus. Amino acid substitutions in the presumed pore of GluClalpha conferred direct glutamate gating indicating that GluClalpha is deficient in coupling of ligand binding to channel gating. Heteromeric channels of GluClalpha+beta may differ from the prototypic muscle nicotinic acetylcholine receptor in that they have the potential to bind ligand to all of the subunits forming the channel.Journal of Biological Chemistry 08/1996; 271(27):16035-9. · 4.60 Impact Factor
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209.29 | Total Impact Points | |

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Some Community Benchmarks Against The NVIDIA Tegra K1
Published on 02 May 2014 12:20 AM EDT
Written by
Michael Larabel
4 Comments
In continuation of the
Trying Out The Jetson TK1, NVIDIA's High-End Tegra K1 Board
Benchmarks Of The NVIDIA Tegra K1 and Its Hotness
articles, here's some results provided by the community compared to my early NVIDIA Jetson TK1 board with Tegra K1 SoC.
Later today I should be offering up my first "official" (proper) results of the Jetson TK1 ARM board with its Tegra K1 SoC sporting a Kepler GPU with quad-core Cortex-A15 CPU core (and companion core) while in the time since sharing yesterday's standalone Jetson TK1 results there's been some benchmark result uploads by the community.
From yesterday's standalone results in the aforelinked articles, it's as easy as installing the
Phoronix Test Suite
and then running
phoronix-test-suite benchmark 1405010-KH-NVIDIATEG94
For those really curious to see how this sub-$200 ARM board performs, some that have uploaded their initial comparison data publicly via our Linux benchmarking software includes:
- The Jetson TK1 results compared to an Intel Core i5 2500K "Sandy Bridge" system running Linux Mint 16.
- Some Arch Linux benchmarks against a single-core 2.13GHz 64-bit system.
- These are some results comparing the 32-bit Tegra K1 ARM development platform against an Intel Celeron J1900 quad-core 1.99GHz CPU while running Ubuntu 14.04... This result file should yield likely some of the most interesting data prior to our performance reveal in the coming hours.
- Some NVIDIA Tegra K1 Ubuntu Linux results compared to an Intel Core i5 750 system running openSUSE 13.1 with the Linux 3.11 kernel.
Stay tuned for more interesting Phoronix test data from the Jetson TK1 shortly! If you appreciate all this Linux benchmarking, please become a
Phoronix Premium subscriber
, which goes to support this site -- including the buying of the NVIDIA Jetson TK1 ARM development board.
4 Comments
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About The Author
Michael Larabel is the principal author of Phoronix.com and founded the web-site in 2004 with a focus on enriching the Linux hardware experience and being the largest web-site devoted to Linux hardware reviews, particularly for products relevant to Linux gamers and enthusiasts but also commonly reviewing servers/workstations and embedded Linux devices. Michael has written more than 10,000 articles covering the state of Linux hardware support, Linux performance, graphics hardware drivers, and other topics. Michael is also the lead developer of the
Phoronix Test Suite
, and
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or contacted via
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Snowball Finance is an online financial service firm pursuing value investment.
There are two sites under Snowball Finance. One is iMeigu.com dedicated to serve the Chinese investors in American stock. The other is iChinaStock.com, an English site targeting global investors in US-listed Chinese Companies. The company provides stocks quotes, business news and analysis reports.
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5 Tips to de-stress into your best orgasm by Diane Mallek Jan 19, 2011 Share Tweet Pin Share Save Having a great orgasm may seem like a dream to many women and it is no wonder that this is the case. These days, women are pulled in every direction and having an orgasm ranks pretty low on your list of priorities. Having a mind-blowing orgasm doesn't have to be a fantasy, though. Read on for five tips to help you de-stress into an amazing orgasm tonight. Read Full Story
Sex toys: How to introduce them into the bedroom by Diane Mallek Jan 19, 2011 Share Tweet Pin Share Save Did you know that only 30 percent of women can orgasm from intercourse alone? That means that many women are finding other ways to get the job done. While introducing a sex toy into the bedroom could add excitement to your sex life, it could also leave one partner feeling confused. With these tips, introducing a sex toy doesn't have to be such a touchy subject. Read Full Story
5 Fun sex toys to try with your partner by Diane Mallek Jan 19, 2011 Share Tweet Pin Share Save Looking to spice up your sex life with a sex toy? They can be a lot of fun, but the wide variety of sex toys out there can leave you feeling overwhelmed and even more so if you've never used a sex toy with your partner. Here are a few ideas that will spark your curiosity and leave you both feeling thoroughly fulfilled. Read Full Story
How to help yourself to a great orgasm by Diane Mallek Oct 03, 2010 Share Tweet Pin Share Save The number-one sex complaint among women is the lack of fulfilling orgasms. You don't have to settle for a sub-par climax, though. By taking a few tips into consideration right now, you'll be well on your way to an amazing orgasm tonight. Read Full Story


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Kathryn (Kay) Frances Kozelka, 64, was called to heaven on Sept. 23, after a long battle with cancer. She fought with grace and courage, always staying positive and living each day to the fullest.
She was born on Jan. 2, 1950, to Kenneth and Mary (Sabins) DuCharme. She grew up in rural Seneca, where she was proud to be raised on a farm, making memories with her brothers. Family remained the most important thing to Kay throughout her life.
John William Wilkinson, 78, of Mt. Hope, passed away on Wednesday, Sept. 24, at Gundersen Lutheran Medical Center in La Crosse.
Linda Schulkamp, 64, former owner/operator of the Valley View Inn and West Grant High School board member, has passed away.
Linda and her family were residents of Grant County for many years and met wonderful customers at the Valley View Inn who became friends. Linda employed many West Grant students and taught them about work ethic and success.
Linda is survived by her husband, Dan; her children, David and Darcie; and her grandchildren, Isaiah and Hayden.
Jenny Jeanne (Conlon) Manning, 51, of Harpers Ferry, Iowa died peacefully with her family at her side on Sunday, Sept. 21, at her home.
She was born on Nov. 23, 1962 to Rodger and Ann (Koenig) Conlon in Dubuque, Iowa. Jenny graduated from Wahlert High School in Dubuque, Iowa. She also attended Capri College for Cosmetology and graduated from Loras College in Dubuque, with a business degree. Jenny settled in McGregor, and worked as a cosmetologist in her own shop, "Jenny's Shear Magic," where she enjoyed her elderly clientele and the surrounding community.
Floyd F. Lemke, 91, of Prairie du Chien and formerly of Racine, passed away Friday, Sept. 19, at the Prairie Maison Care Center in Prairie du Chien.
He was born Dec. 23, 1922 in Kenosha, the son of Frederick and Nellie (Woodward) Lemke. He served in the U.S. Coast Guard during WWII. He married Lois Sheffer on Nov. 12, 1949 at Christ Methodist Church in Racine. Floyd worked as an engineer for Dynamatic Corporation in Racine for many years until his retirement. He was known as a great "handyman" among family and friends and was an avid fisherman.
Allen LeRoy Koecke, 88, passed away on Wednesday, Sept. 10.
He was born on May 14, 1926, in Prairie du Chien. Allen was united in marriage to Loretta Barrette. She preceded him in death. He was a veteran of the U.S. Army Air Corps proudly serving towards the end of World War II. Allen worked at various grocery stores and was a very loyal member of the Teamsters Union. He enjoyed traveling, exploring Europe and Alaska but truly treasured most the times spent at their summer lakeside home on Winter Lake.
Ronald Paul Martin, 68, passed away peacefully surrounded by family on Sept. 17 after a courageous battle with cancer.
Ron was born Christmas day, 1945, in Prairie du Chien to Paul and Cleo (Groom) Martin.
Ron leaves behind is wife, Ana; daughter Terri; sons Steven (Jenny) and David (Katie); grandsons Braylon and Jacob; and siblings Frank (Sue), Terri (Rich) Messling, Linda Messling, Mike (Deb). He was preceded in death by his parents, sister Rita and brother Steve.
On Tuesday, Sept. 9, at 3:01 p.m. our beloved Francesca Elise Brown Santoro was stillborn and left this world at 36 weeks of pregnancy. The Sunday prior, her heart stopped beating for no known reason and she was born a beautiful, perfect angel at 5 lb 14 oz, and 18 inches long. We were blessed to be able to give her the natural birth we had envisioned for her- it was peaceful and silent.
Phyllis M. Gokey, 88, of Prairie du Chien passed away peacefully in her sleep on Wednesday, Sept. 17, at her home.
Ann Forbes, 87, of Manawa, went to her heavenly home on Tuesday, Sept. 2, at Bethany Home in Waupaca.
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Many people believe the Clinger-Cohen Act of 1996 gives agency CIOs sufficient authority, but at least one prominent Senate lawmaker isn't so sure.
Recharging the CIO
Sen. Susan Collins (R-Maine) recently asked the Government Accountability Office to assess the statutory framework for CIOs and evaluate potential modifications to enhance the authority of CIOs.
"In 2011, it will be 15 years since the enactment of Clinger-Cohen and more than six years since GAO completed work on this topic; however, challenges in implementing and overseeing major information technology investments still persist," Collins wrote in a Feb. 12 letter to GAO. "Specifically, the position of CIOs is not equally respected across the federal government and according to a recent survey, CIOs still lack adequate resources to achieve technology efficiencies and improve organization performance."
Collins, ranking member of the Homeland Security and Governmental Affairs Committee, said in the letter that she is interested in learning about proposed legislative improvements to the existing law.
Per Collins' request, GAO has begun a study to examine the roles and responsibilities of agency CIOs, said Charles Young, GAO's managing director of public affairs.
Young said GAO is obtaining information from CIOs at 30 federal agencies and will hold a panel discussion with former CIOs March 22. The former CIOs will be asked to share their views regarding the statutory responsibilities given to federal CIOs, lessons learned in managing IT, and areas in which changes might be made to enhance CIOs' authority and effectiveness.
A spokesperson for Collins said GAO is expected to report on its findings sometime this summer, and those findings will determine the next steps, such as a hearing or legislation.
The idea of updating Clinger-Cohen isn't new, but it didn't have much momentum without a champion on Capitol Hill, observers say. Now that Collins is taking the lead on the issue, the debate about CIOs is far from finished.
About the Author
Alyah Khan is a staff writer covering IT policy.
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FCW is proud to support this Feb. 9 event to help the soldiers of Operation Iraqi Freedom and Operation Enduring Freedom transition to civilian careers.
Click here to learn more
FCW investigated efforts by the departments of Defense and Veterans Affairs to improve a joint data repository on military and veteran suicides. Something as impersonal and mundane as incomplete datasets could be exacerbating a national tragedy.
Despite delays, the program is at a critical point for determining the ultimate impact of cloud technology in the government space.
In an interview with FCW, the Department of Veterans Affairs' chief technology officer talks about overhauling the digital experience for VA customers.
The National Information Exchange Model's usefulness extends far beyond its origins in justice and law enforcement.
ACT-IAC'S Rick Holgate and Dan Chenok look ahead to what's next for federal IT in 2015.
A bill that will allow DHS to hire cybersecurity professionals faster and pay them more now heads to the president for his signature.
How NASA and other agencies are using contests to bring better ideas into acquisition.
ONC will focus more on data interoperability and the use of health IT to improve patient outcomes.
A new report from the DOD CIO offers soup-to-nuts guidance on security for commercial cloud providers and Defense Department customers.


text: I am glad to have been able to be a support. My life has been full of blessings since then. CHILD MENT My precious boy had a big hand in my beautiful rainbow baby. His little sister had a due date just 5 days later than his was and she was born just six days after I posted this thread. It was extremely hard to deal with that day, but I could feel his little arms around my neck letting me know that all is well. I pray that you are blessed with your rainbow babe(s) soon.


text: No recent wiki edits to this page. JitaJita is located in the Kimotoro constellation of the Forge region. With arround 1000 Pilots on average, and up to about 1500 Pilots at weekends, Jita is by far the crowdiest place in New Eden. Since several high level agents conducted their business from the system's stations many of the pod pilots started to trade at the Caldari Navy Assembly Plant orbiting the fourth Moon of the fourth planet. The facts that Jita is nearly in the Center of the other Trade Hubs in Empire (Amarr, Rens, Dodixie and Hek), close to 4 other regions (for price comparison) and near most of the Caldari starting Points are also helping in populating this System.Due to its High population Jita is a very vulnerable system when it comes to lag issues. All of Jita's Asteroid Belts (it used to have 8 Asteroid Belts and 3 Ice Fields) as well as the - at that time - busiest Gate (to Kisogo) have been permanently removed from the System in order to help removing the lag, or at least getting it down to acceptable levels. Jita is currently one of the 5 Systems in EVE that runs on its own dedicated Server Hardware.The current volume of trade conducted in Jita totals several billion ISK a day, more than all other Trade Hubs combined.


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"Instead of dreaming of being a teacher or a lawyer or a business leader, they're fantasizing about being a baller or a rapper."– First lady Michelle Obama, delivering the commencement address in Maryland on Friday to Bowie State University, an historically black university.
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I would like to breed my AKC Long Haired German Shepherd Arabella. I am a small hobby breeder of AKC Champion Finch bloodline Pomeranians for many years now. I have recently got into German Shepherds and will consider breeding my LCGSD if I can find the right stud for her. ...
Both are male and female. 347-440-4535
Lady Gouldian Finches for sale in the Allentown área. Male and female available, normal yellow and blue, starting from $65.00-$125.00
Hi Guys, I have finches for sale, they are 10 months old ready for breeding, If you are interesting in buying contact me at the following: 7812671272 or email me at [email removed]. Thanks.
For sale $65.00 This ad was posted with the eBay Classifieds mobile app.
I have 2 very cute 2 year old finches for sale. One is a Zebra finch and the other is a Society Finch. I don't know their genders. They absolutely love each other and cannot be separated. There's a small rehoming fee of $15. I need to minimize my flock so I need to find a ...
We have a limited amount of fully colored blue gouldian finches available now for only 85 each. Males and females available ready to breed.
Hi I have mostly Lady Gouldian Finches for sale from greens to silvers ranging from 60 to 120 .And i also have some other types finches just ask. Shipping now available thru USPS Thanks
for sale 3 lavender waxbill finch and one female start finch call me a (917)557-9161
Beautiful, young , healthy Gouldian Finches. Males and females available. Some non-related pairs. Sorry, no shipping! Normals on sale while supplies last Males (RHPB/RHLB) $65.00 Hens (BHPB/BHWB/RHPB/OHPB) $65.00 Also Owl Finches, unsexed, all related $65.00
I have a few male gouldians for sale. A RH/PB/BB $125 SOLD BH/PB/GB-split for BB $75 SOLD BH/WB/GB-split for BB $75 OH/WB/GB-split for BB $75 & an OH/PB/GB $65 SOLD. Please be sure of my location before contacting me. I cannot meet or ship & prices are firm. Located in ...
I have decided to downsize & therefore all of my owl finches are available for sale. I have six birds left $60 each.Please be sure of my location before contacting me. I cannot meet or ship & prices are firm. Located in Benton PA 17814 *UPDATE* Two birds left.
FOR SALE, Beautiful Bird Art all custom hand painted on feathers, with frames ready to be displayed in your home, you can special order any bird you like, price very on birds. most measure 14" to 17" long & 7 1/2" to 8 1/2" wide. ALSO HAVE A GOLD FINCH , HUMMINGBIRD, RED ...
The Society Finches are $20 a pair
Java finch for sale we have them young, and adults. No more grey only white.
Parent raised Lady Gouldian Finches for sale. Healthy, closed banded 2014 males and females. Various colors and split to different colors. Normal greens, dilutes, split to blue, split to white chested, purple chested. Red, Black, Orange heads...various combinations. Call or ...
Big sale on canaries and finches text me for more information This ad was posted with the eBay Classifieds mobile app.
email me if interested [email removed]
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Best Schools in Civic Center
P.S.1 Charter School Charter • Grades 6-12
147 students • 15 student/teacher -
Life Skills Center of Denver Charter • Grades 9-12
232 students • 19 student/teacher
Which schools are assigned to my home?
About Civic Center
Civic Center has 3 schools. One of the highest rated schools is P.S.1 Charter School, which is rated 1. P.S.1 Charter School has 147 children. The public schools in Civic Center are in Denver Public Schools. Denver 1 School District is nearby and scores higher than Denver Public Schools. Nearby Englewood School District No. 1 In The County Of Arapahoe scores lower, with a rating of 3.
School Districts Near Civic Center
Disclaimer: School attendance zone boundaries are supplied by Maponics and are subject to change. Check with the applicable school district prior to making a decision based on these boundaries.


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Katie Holmes dropped a bombshell last week when she announced that after five years of marriage she would be divorcing Tom Cruise. But before filing for divorce , did Holmes hint that there was trouble in paradise? It certainly seems like it. Six weeks prior to announcing the split, Holmes sat down with Elle magazine for the August issue and may have suggested that she was ready to move on.
"He has been Tom Cruise for 30 years. … I know who I am and where I am and where I want to go," Holmes said. "So I want to focus on that."
Holmes, who began dating Cruise when she was 26, told the magazine that now that she is in her 30s, she is entering a new period in her life, finally becoming the person she wants to be.
"I definitely feel much more comfortable in my own skin. I feel sexier. I think in my twenties — it's like you're trying too hard to figure everything out. … I'm starting to come into my own," Holmes, 33, said. "It's like a new phase."
And that new phase will have her being seen as Katie Holmes and not Mrs. Tom Cruise. Holmes reveals that even though she was married to the highest-paid actor in Hollywood, it didn't make things any easier for her in terms of her career.
"Things are not handed to anyone," Holmes said. "If anything, you work a little bit harder when you're in such visible circumstances."
It seems Holmes knew at the time that she was headed for a divorce since in her filing she noted that her relationship had been "irretrievably" broken for more than six months.
On Wednesday, Holmes was swarmed by paparazzi in New York while running errands with daughter Suri.
"I'm all right," Holmes told a reporter from the New York Daily News. "Thank you."
The August issue of Elle magazine hits newsstands July 17.


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RSS Owl | RSS / RDF / Atom Feed Reader RSS Owl is a powerful application to organize, search and read feeds.
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Emonic Emonic (Eclipse-Mono-Integration) is a Eclipse-Plugin for C#. It provides color-highlighting, outline, word-completion and build mechanism via Ant or Nant. Tested on Linux and Windows with Mono and the Win-.net-framework.
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Turn Off Monitor This utility is used to turn off monitor for PC, notebook, or netbook which is have monitor. Just run the program, then your monitor will be turned off. Actually this program used for notebook or netbook which is used for conserve the battery.
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DRX DRX is a powerful exploration, auditing, and documentation tool that allows Documentum administrators and developers to quickly document vital information about their repositories and environments. DRX provides a simple UI to facilitate logging into the Documentum repository, configuring and running specific reporting modules, and viewing the resultant reports. DRX reports are generated in HTML for easy viewing and XML for more complex processing. DRX is distributed as an EXE file that contains all of the Java code, requisite libraries, JVM and the DFC required to run the program. Its compact distribution and simple installation (simply unzip it!) make it easy to run from a memory stick or move from one computer to another. See a missing module? Want enhancements to an existing one? Join the DRX Project Team! YourKit is kindly supporting the DRX open source project with its full-featured Java Profiler: http://www.yourkit.com/java/profiler/index.jsp
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Synthclipse GLSL shader prototyping tool based on Eclipse IDE.
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RESTful Plugin for Eclipse RESTful Plugin for eclipse helps the user to create a RESTful web service in one click. 1) Spring RESTful Webservice 2) Jersey RESTful Webservice 3) RESTEasy RESTful Webservice 4) Restlet RESTful Webservice Company URL : http://oneclicklabs.org Product URL : http://restful.karthy.me
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XML-Print XML-Print: typesetting arbitrary XML documents in high quality
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IusCL Delphi7 style, Windows Java SWT based component library and Eclipse development plug-in IusCL is an Eclipse plug-in that offers an application development style similar to Delphi7. It is built around a library containing a class hierarchy similar to VCL and based on SWT for the UI part. The library can be distributed with the developed applications, in the terms of the Eclipse Public License. The project is functional, but the documentation is not on a functional state yet. It should be installed as a normal Eclipse plug-in, and then its use should hopefully be intuitive, as this is one of the goals of the project.
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PC-Lint Wizard A GUI tool for easily setting up and maintaining PC-Lint for your projects.
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J'Equity Financial program
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High Overnight Blood Pressure Leads to Kidney Disease
A five-year study measuring overnight blood pressure in 75 adolescents and young adults with type 1 diabetes revealed that high nighttime blood pressure can lead to kidney disease.
Subjects wore blood pressure devices that measured levels around the clock at the beginning of the study and again two years later. Researchers subsequently continued to monitor the subjects for microalbuminuria.
The study reports that the 14 subjects who developed microalbuminuria had registered high levels of systolic blood pressure while asleep.
Microalbuminuria is defined as a urinary protein excretion rate of between 30 and 300 mg over a 24-hour period. Systolic blood pressure, the top number in the blood pressure reading, is the pressure measured as the heart beats.
The researchers found that, in people with type 1 diabetes, high systolic blood pressure during sleep precedes the development of microalbuminuria, which is less likely to develop in those whose blood pressure decreases normally during sleeping hours.
-New England Journal of Medicine, September 12, 2002
Click Here To View Or Post CommentsCategories: Adolescent Boys, Adolescent Girls, Diabetes, Diabetes, Kidney Care (Nephropathy), Type 1 Issues


text:
From CCDA
6JSC/LC/12 Priority order of additions to authorized access points representing a person (184.108.40.206, 126.96.36.199, 184.108.40.206)
To enter your comments in this click on the [edit] link for the section where you want to comment. You must be logged in to comment.
Please include in your comments:
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Never copy and paste over the entire original wiki document.
General comments
NLM strongly supports this proposal.
-- Glennan (PCC) for NLM, 8/31/12


text: Pittella JE, Gusmão SN. Diffuse vascular injury in fatal road traffic accident victims: its relationship to diffuse axonal injury. J Forensic Sci. 2003 May;48(3):626-30. PubMed. Recommends Please login to recommend the paper. Comments Make a Comment To make a comment you must login or register. Comments on this content No Available Comments


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Print and e-file W2, 1099-MISC, 1099-INT, 1099-DIV, 1099-R and other tax forms.Windows Version 11.0.48 ... Added: 01/12/15Total Downloads36,756Last Week154
Erie drops you into a visually stunning, yet terrifying scenario where your goals are to investigate, survive, and finally escape.Windows Version 1.08 ... Added: 10/15/12Total Downloads21,635Last Week82
Plunder melds and run with this jewel.Windows Version 7.42 ... Added: 10/04/11Total Downloads42,480Last Week77
Introducing Photofy 3.0!Photofy is a super-easy photo enhancement app for consumers and businesses that combines the worlds largest collection of...iOS Version 3.0 ... Added: 11/04/14Total Downloads532Last Week30
2013 Big Ten Football ScheduleAndroid Version 1.0 ... Added: 08/26/13Total Downloads404Last Week14
Build houses and industrial buildings, produce goods, and deliver them to the shopping malls.Windows Version 2.5 ... Added: 06/01/11Total Downloads3,327Last Week14
The SHERATON CHICAGO HOTEL & TOWERS is Chicago's premier downtown riverfront hotel, just off Michigan Avenue, and within a short walk of Navy Pier,...iOS Version 1.1 ... Added: 09/03/10Total Downloads6Last Week8
Add a collection of Eminem images to your desktop.Windows Version 1 ... Added: 12/19/07Total Downloads2,968Last Week5
Play the classic card games in the Rummy family.Windows Version 3.15 ... Added: 01/14/15Total Downloads453Last Week5
Sex offender search shows the exact locations of all sex offendersAndroid Version 1.0 ... Added: 12/26/14Total Downloads33Last Week5
Improve your odds of winning lotteries with a result analyzer.Windows Version 6.0.6 ... Added: 01/31/13Total Downloads14,037Last Week5
Topos East is an app that provides access to download and view high resolution USGS topographic maps for the eastern region of the United States....iOS Version 1.1 ... Added: 02/01/12Total Downloads5Last Week1
Lake Michigan Credit Unions App is convenient, easy to use, free and secure.Android Version 3.0.2 ... Added: 11/09/14Total Downloads4Last Week4
PlayMaker Pro for iOS enables you to display PlayMaker Pro documents for American Football or Canadian Football on an iPad, iPhone or iPod Touch....iOS Version 1.4 ... Added: 03/02/13Total Downloads202Last Week4
Perform MySQL administration and development.Mac Version 11.1 ... Added: 08/25/14Total Downloads3,470Last Week4
Create a customized, state specific and printable Michigan Promissory Note.Windows Version 1.0 ... Added: 04/01/14Total Downloads133Last Week4
Developed by students at Harvard's computer science and Harvard's psychology department, as well as students from the University of Michigan's...iOS Version 1.1 ... Added: 07/01/12Total Downloads5Last Week1
Children of God Mary Doria Russell Ballantine Books December 18, 2007 Mary Doria Russell's debut novel, The Sparrow, took us on a journey to a...iOS Version 3.0.1 ... Added: 08/25/10Total Downloads18Last Week3
Tennessee Statutes (TN Laws & codes) on your Android devicesFeatures: Complete offline access -No need of Internet Connection nor any Printed books...Android Version 1.1 ... Added: 12/06/12Total Downloads6Last Week3
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fast facts about statesMobile Version 1.0 ... Added: 12/17/02Total Downloads81Last Week2
NOTE: Internet connectivity is required (Edge, 3G, or WIFI)! Campus to Campus is the official iPhone application for Magic Bus at the University of...iOS Version 1.0 ... Added: 01/13/10Total Downloads4Last Week2
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Proud recipient of the Childrens Technology Review Editors Choice Award and named a Top 10 App by Apps4Kids!This version is for iPhone and iPod...iOS Version 1.2 ... Added: 07/23/11Total Downloads2Last Week2
The future is already rooted in the presentit has happenedSpoken by Merlin in ExcaliburThis work of fiction is structured in episodes. Meetings...iOS Version 1.0 ... Added: 05/21/10Total Downloads7Last Week2
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When you're on the go, TV5 brings you Michigan coverage you can count on, via your iPhone or iPod Touch.Now you can get breaking news, local...iOS Version 2.8 ... Added: 08/05/11Total Downloads4Last Week2


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Quick Take: Invest in Tech Dividends With an ETF
NEW YORK ( TheStreet) -- Although a technology dividend ETF would have probably been a joke 10 years ago, First Trust recognizes its potential today. First Trust strategists Ryan Issakainen and TheStreet's Gregg Greenberg are here with the breakdown.
Over the last five or six years, investors have seen many more technology companies initiate dividend payouts. Due to their strong balance sheets, this is certainly a plausible strategy for maturing companies that still have strong cash flows.
In fact, technology stocks are actually the largest dividend contributor to the S&P 500's dividend payouts.
That's why First Trust decided that it made sense to have a technology dividend ETF. But does that mean that the companies in it are all but done growing?
Not necessarily, according to Issakainen. He said that while companies such as Microsoft (MSFT), Intel (INTC) and IBM (IBM) all have strong payouts, they also have strong free cash flows. Add in low debt, experience and a lot of cash, and it strengthens Issakainen's argument that these companies will continue to increase their dividends. Although dividends make sense for mature tech titans, what about the young companies? He says that new technology companies are likely better off reinvesting in themselves. He added that companies such as Facebook (FB) would do shareholders a disservice by paying out a dividend, rather than finding new potential growth outlets to exploit. -- Written by Bret Kenwell in Petoskey, Mich. . Follow @BretKenwellCheck Out Our Best Services for Investors
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