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State Rep. Mark Longietti today was sworn in for a fifth, two-year term representing the 7th Legislative District in Mercer County during a ceremony at the state Capitol that started the 2015-16 legislative session. Longietti, D-Mercer, will look to extend his eight-year record of perfect attendance when the House is in session. Read more
HARRISBURG, Jan. 26 – The Basic Education Funding Commission will hold a hearing beginning at 10 a.m. Thursday at Greenville Junior/Senior High School, 9 Donation Road, Greenville, state Rep. Mark Longietti announced. "This hearing will allow school officials from Mercer and neighboring counties to provide input about how the state distributes money to help support basic education," said Longietti, who is a member of the commission. "The hearing is open to the public, and we have set aside time at the conclusion of the meeting to listen to comments from local residents." The agenda for the hearing is: 10:05 a.m. – Testimony from Greenville Area School District Superintendent Mark Ferrara, Sharon City School District Superintendent Michael Calla, Hermitage School District Superintendent Daniel J. Bell and Sharpsville Area School District Superintendent Brad Ferko; 11:05 a.m. – Testimony from Austin Area School District Acting Superintendent Jerome Sasala; 11:35 a.m. – Testimony from Propel Schools Foundation founder and Executive Director Jeremy Resnick and Keystone Charter School CEO Mike Gentile; 12:15 p.m. – Testimony from Erie School District Superintendent Jay Badams and Corry School District Superintendent Bill Nichols; Public comments. The bipartisan, bicameral 15-member commission was created by Act 51 of 2014, and consists of senators and representatives from across Read more
HARRISBURG, Jan. 21 – State Rep. Mark Longietti, D-Mercer, was appointed to serve on four House committees for the 2015-16 legislative session: Commerce, Education, Tourism and Recreational Development, and Consumer Affairs. "I will be a strong voice for Mercer County residents as these committees vet legislation," Longietti said. "These committees handle legislation that affects the day-to-day lives of everyone in Pennsylvania, and I'm excited to serve on them." Longietti also was unanimously re-elected to serve as chairman of the Northwest Democratic Caucus. The Northwest Democratic Caucus is one of six regional caucuses within the House Democratic Caucus. "This position allows me to advocate for our region's interests," Longietti said. Longietti was reappointed vice chairman of the House Democratic Policy Committee by its chairman, state Rep. Michael Sturla, D-Lancaster. As a vice chairman, Longietti will help develop the caucus' policy agenda, determine topics for public hearings and act as a liaison to other caucus members on policy ideas. Longietti is serving on the Basic Education Funding Commission, which is charged with developing a formula to best distribute money from the state to help fund basic education. Longietti also serves as co-chairman of the 130-member, bicameral, bipartisan Early Childhood Education Caucus. Read more
June will be here before we know it, and many graduating seniors and their parents are thinking about college applications and, more importantly, how to pay tuition bills. I'm urging college-bound high school seniors and their families to consider applying as soon as possible for financial assistance by submitting the FAFSA – the Free Application for Federal Student Aid. The FAFSA is a must for determining eligibility for most need- and income-based financial assistance, including the Pennsylvania State Grant , Pell grants and other federal student loans, work-study programs and various scholarships. The FAFSA may be completed online at www.fafsa.gov . The form is also available on my website by clcking on the education tab under Help & Services. Read more
HARRISBURG, Jan. 8 – State Rep. Mark Longietti, D-Mercer, announced that two local libraries will receive state grants totaling nearly $83,000. The Community Library of the Shenango Valley will receive $53,150 and the Stey-Nevant Public Library in Farrell will receive $27,656. The Community Library of the Shenango Valley plans to make the front entrance and restrooms handicapped accessible, Longietti said. Stey-Nevant Library, Longietti said, will use the grant to replace old light fixtures, which use bulbs that are no longer being manufactured, with modern, energy-efficient lighting and replace back doors, which have become worn and are difficult to latch securely. "These libraries are important community resources, and I'm pleased that the state will be providing much needed assistance to make these upgrades," said Longietti, who wrote a letter of support for the libraries' grant applications. Stey-Nevant Librarian Margaret Orchard and Frank Gargiulo, board president for the Community Library of the Shenango Valley, welcomed the news. "This is the answer to my prayers," Orchard said. "It will certainly make a difference in the look of the library." "Our board and staff thank the state for viewing the project worthy of funding," Gargiulo said. "We appreciate the work and support of all those who contributed to this effort." The grants were awarded through the Keystone Fund Read more
HARRISBURG, Jan. 7 – State Rep. Mark Longietti announced that Greenville has received a $500,000 state grant to expand and renovate the Greenville Area Public Library. "During the past five years, the Greenville Area Public Library has had a 120 percent increase in attendance," said Longietti, who wrote a letter in support of the library's grant application. "The library needs improvements to properly serve the community, and this grant is critical to the borough's plan." "We are delighted that the commonwealth is investing in the Greenville Public Library," said John Hauser, president of the Greenville Area Public Library Board of Directors. "We have a dynamic program and this will help us move to the next level." Hauser thanked Longietti, former state Sen. Bob Robbins and current state Sen. Michele Brooks for supporting the grant application. The $1.4 million project includes additions to the west side and front of the library to add 1,535 square feet of space, moving the children's library to the lower level so it has more room to accommodate the growing children's program, and installing an elevator and making the entire building handicapped accessible. The work also includes adding a new meeting/reading room, renovating work room areas to improve efficiency, and installing LED light fixtures. This is the first renovation to the building since it opened in Read more
The 99th Annual Pennsylvania Farm Show will take place from Jan. 10 to the 17 in the Pennsylvania Farm Show Complex & Expo Center on North Cameron and Maclay streets in Harrisburg. The Farm Show is the largest indoor agricultural exposition in the nation, with nearly 6,000 animals, 10,000 competitive exhibits and 300 commercial exhibits. It features the hard work of Pennsylvanians statewide, who showcase their work year-round in county fairs, with civic groups and among trade organizations. Read more
Pennsylvania has a Children's Health Insurance Program that provides free and low-cost health insurance to children. CHIP is not welfare – it covers children of working parents whose employers don't offer coverage and who can't afford private insurance. If you can't afford health insurance for your children, chances are they are eligible for CHIP. Read more
Each year, the Pennsylvania Treasury receives millions of dollars of unclaimed property. It is estimated that roughly one in 10 Pennsylvanians has unclaimed property. Read more
Landmark legislation passed during the 2013-14 Legislative Session now allows first responders, including law enforcement, fire fighters, EMS or other organizations the ability to administer a medication known as naloxone, a life-saving opioid-overdose antidote. The law also allows individuals such as friends or family members who might be in a position to help a person at risk of experiencing an opioid-related overdose to obtain a prescription for naloxone. Additionally, Act 139 provides immunity from prosecution for those responding to and reporting overdoses. Read more
House Bill 993, which renamed the Pennsylvania Department of Public Welfare as the Pennsylvania Department of Human Services, was signed into law as Act 132 during the 2013-14 Legislative Session. According to advocates for the change, renaming the department was long overdue, and as the Pittsburgh Post-Gazette reported, the name change better reflects the department's mission. Read more
I am here to help you with any state government-related issue you might have. Below are some of the most common websites that can answer your questions. For more help, or to speak with me or a staff member about an issue, please don't hesitate to contact my office.


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I am developing an application connecting a PC with Android based device over bluetooth, I have established the connection and implemented most of my project ideas.
However, I would like to add streaming functionality from the PC to the device, I don't have any code yet as I am still in the planning stage! So I would like to ask for any helpful resources or tutorials? anything helpful as a first step?
I have implemented the PC side where I basically get the stream frames in the form of byte array, to be sent to the Android side...
Any help would be highly appreciated

subset: commoncrawl


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Definition of Melanoma, superficial spreadingMelanoma, superficial spreading: One of the four clinical types of malignant melanoma, the most common type in white people, which typically presents as a raised, irregular, colored area that starts in a mole-like shape and spreads across the skin. Source: MedTerms™ Medical Dictionaryhttp://www.medicinenet.com/script/main/art.asp?articlekey=11639 Last Editorial Review: 3/19/2012 Medical Dictionary Definitions A - ZSearch Medical Dictionary
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I often wonder if my mother realized how she was equipping me for a sustainable life style when she taught me crafts like crochet, knitting and making jewelry. Learning those crafts helped me with academics too. Reading patterns helped me…
My Perfect Pantry: 150 Easy Recipes from 50 Essential Ingredients
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I think everyone has their preference for the type of camera they purchase. I personally own a Canon EOS Rebel T5i and I'm not alone as it is the best-selling DSLR camera. Mine is easy to use and the advanced…


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According to industry estimates, the country's highly-fragmented mini-truck transportation industry is valued at between $4.8 billion and $9 billion.
A 'smart' microwave oven application built by a campus startup has met its crowd-funding target of $50,000 within just six days of the launch.
UTI Mutual Fund today said its 'Focussed Equity Fund - Series II' closed with an overwhelming response and garnered around Rs 900 crore.
The company's move comes after the US government's development finance institution OPIC agreed to invest $42 million in the fund.
A fast-growing segment of US retirement plans is using hedge-fund type strategies to bet a small but increasing slice of their assets.
The scheme aims to provide long term capital growth by investing in a well-diversified portfolio of equity and equity related securities across m-cap and sectors.
SBI MF, which had earlier plans to launch this scheme on December 1, is now reviewing the structure of the product.
Indiabulls Mutual Fund today said it has launched a new scheme Indiabulls Arbitrage Fund, which would predominantly be long cash market-short future market.


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RJ Crap, all of it. Let's see, take a really bad situation with basketball cards this year and compound it with completely ambiguous REDEMPTIONS. Awful, awful, awful. Posted May 18, 2012 at 1:02 am | Permalink
RJ It's bad enough if, say, you want to buy a REDEMPTION card for Kyrie Irving, Jimmer Fredette or Anthony Davis, just because of the uncertainty of whether/how long it takes for them to sign and for how long you'll have to wait for your card. Now, you don't even know which REDEMPTION you have? Seriously, who thinks of this stuff? Do any of them read the forums/blogs? For what it's worth, I really like Panini basketball cards … I just think they did a horrible job this year, and to me, the lockout is only an excuse for the first product or two of the season. There is absolutely NO excuse for not having just base cards of rookies in a product that releases in the middle of May — almost five months after the season started! Posted May 18, 2012 at 1:14 am | Permalink
Richard Not the first time a redemption was not known who it was for. Finest had it such that you actually needed to look at the serial # to see who you were going to get. Posted May 18, 2012 at 3:12 am | Permalink
Heath chasing something you don't know what your chasing , and then having to wait until october to find out what you got ? The season is long over for these rookies, your telling me it takes this long to make an actual card of them, and then your going to try and spin it off in some redemption plan. maybe panini should have stayed in the sticker market overseas. They may as well just make National Treasures and be done . everything looks the same, and loaded with the same $2-4 hits. Posted May 18, 2012 at 6:08 am | Permalink
JeffNSU Blame the league and the players for the lockout. That caused all the problems this year. Some sellers on eBay are confused and are selling the 2011 auto redemptions based on the slot the player was drafted instead of knowing that it will be a random draw. I've been able to get a bunch of redemptions under $50 because of stupid sellers. Posted May 18, 2012 at 10:43 am | Permalink
Corey So where does that put the Irving National Card Convention Promo card, is it no longer going to be worth anything, or is it his true rc? Posted May 18, 2012 at 12:07 pm | Permalink
Steve Dear Panini, I really hope you are listening to this; I was a collector as a kid back in the early 90's. I collected all sports at that time, but later fell out of the hobby like many other people. I have since decided to re-visit the hobby, now in my late twenties. I decided I would focus my collecting only on basketball due to it being my favorite sport. I have bought many of your products this year, including boxes of Hoops, Preferred, and now a couple boxes of Past and Present. While I admire the artistic nature of all the cards you produce, I must say, the "redemption" cards are going to cause you to lose a lot of customers. I wish I could have been a fly on the wall in your marketing meeting when your team made this decision. Although, I don't think I would have been able to contain my laughter… This idea is simply ridiculous. The future of this industry lies in the hands of young people. And as a kid, the last thing I would have wanted to do was open a card and have to wait to "redeem" it several months down the road. How is that fun? Not only that, but the Past and Present set doesn't even allow you the opportunity to know what you're getting. This is a terrible idea… By the time you run your online "draft" for the cards, people are already going to be thinking about the 2012-13 season. No one is going to care about this season's rookie class anymore. I strongly encourage you to consider removing the redemption cards from all future sets. Keep in mind the future of the hobby, which includes a much younger generation of people than the ones making your marketing decisions. If you take the fun out of collecting, you are going to lose that valuable demographic. Thank you. Posted May 18, 2012 at 6:28 pm | Permalink
Nick Tegeler I agree with a lot of other posts on here. Panini is making a big mistake by using MORE redemptions. I hope this is not going to be a every year thing for basketball rookie cards. They already put WAY too many redemptions in their products. More than any other company out there, and that's not to mention they are also the worst at redeeming them or sending a replacement in a timely manner. Plus their customer service stinks to the heavens!!! I am still waiting on cards from 2009-10 and have asked for replacements more than 4 months ago for some and am still waiting on those as well. Every time I call they are having their phone service switched over and that's been going on now for over a month. They must be using cavemen to switch it over, I have NEVER heard of it taking this long to switch a phone service. Posted May 18, 2012 at 9:01 pm | Permalink
Charlie DiPietro Panini was strongly considering not producing any basketball products for 2011-12 because there was no way to economically acquire a significant number of rookie autographs before the season ended. Feedback received from collectors, card shops, internet retailers and distributers convinced Panini that collectors preferred having basketball product this year with draft pick redemptions over not having any basketball products at all. Understanding that people would prefer having actual autographed cards over redemptions, 2011-12 Past & Present Basketball has received very favorable response from box busters in my store. They love the retro designs, the autographs, the inserts and yes, they like pulling the 2011 Draft Pick Auto Redemption Card # 0. While I would prefer not to wait until late October to run the 2011 Draft Pick "Live Draft," no one has complained when they pulled the Card #0 in my store. The concept of running a "Live Draft" for the 2011 Draft Class soon after Panini has acquired the autographs at a signing event is a creative concept. It adds, and will continue to add interest to the product until the "Live Draft." Viewing the prices paid for the "Card #0" on eBay, a significant number of the people who buy cards don't seem to be bothered by the fact that they will have to wait to find out what RC they've won. Pulling a card that consistently sells on eBay from $50 to $150, is much better than pulling an autograph no one wants to buy for $5. Posted May 18, 2012 at 9:47 pm | Permalink
charles faires I would agree with Mr. DePietro that it would be hard for panini to make cards, to a point, they could have done a draft set w/ autos there was plenty of time for that, they do it in football every year, its started before the season begins, they know the teams they use the heck out of photo shop anyway, they use stickers autos all the time, i know even if you don't get complants at your shop, doesn't mean everything is ok, we are given very little recourse, and this doesn't sit well as you can see by most of the comments in this artical, ebay has a lot of bottom feeders, they will play on the posistion panini is forcing on collectors. i don't know, panini is growing as far as redemption king, and maybe thats a title thay don't want Posted May 19, 2012 at 1:57 pm | Permalink
steve yeah…….blame the league & the players-dont blame Panini for being just as corrupt as the owners, the league & most of all-THE PLAYERS !!!! ( these multi-millionaire players, in some cases, who need to sue card companies-for anywheres from a few $K to as much as $50K -I think that was Eli in the NFL…….but still need to 'squeeze' as much as they can because hookers & cocaine aint free people !!). WHO CARES !!!!! collecting was fun….when I started (and still is….most the time) Posted May 19, 2012 at 11:32 pm | Permalink
Kingbudd Will you classify these cards as 2011-12 rookie cards or 2012-13 rookie cards since they are numbered XRC? It would be nice to have a very short print rookie card since only P&P, Limited, and Gold Standard will have 2011-12 rookie cards. But it depends on how you classify these rookies will determine scarcity and drive the price either up or down. Posted May 20, 2012 at 12:46 am | Permalink
Lazer-A Panini: 1. Hire a few photographers. 2. Send photographers to NBA games. 3. Take pictures of rookies. 4. Make cards of said rookies 5. Put them in packs. 6. Don't worry about rookie autographs untill next year when we have a full season. Posted May 20, 2012 at 6:46 am | Permalink
chrisolds Lazer: It's actually simpler than that by using a photo service. Kingbudd: Should be 2011-12 cards. I don't know the final call, but my gut feeling is XRC is likely. Posted May 20, 2012 at 10:33 am | Permalink
XstreamINsanity I really wish I could see the license that the NBA and Panini have so maybe we could see what they state in there, if anything is stated in there, about rookie cards. Even still, regardless what Panini does, they would have gotten flack from somewhere. If they produced regular base RC, people who like RPM and AU RC would have complained. By them doing the draft for the rookie class, they get at least AU in there and maybe even GAME USED material instead of just Event Used material (though, I have a feeling it will be more towards event used). Also, even though I don't want it like this every year, there is something I do like about the draft aspect. When you have a draft that goes two rounds and then you have other signings done in the off season, you can potentially have 60+/- rookies in a year. Many times, the companies will put out rookies from higher picks and more well known schools. By them doing this draft redemption hopefully they'll choose the top performing rookies of the year rather than just who they think should be in it (though I think there are a lot of redemption cards, like 30 or something). That's a hope (and idea Panini if you're reading). However, because I don't know what the license says, I don't know whether Panini is on the hook for rookie cards this year or the league's license. Licenses change over time, so whatever happened 10+ years ago may not be in the contract this time. We'll have rookies in some respect and next year will be better. As far as the redemptions from Panini in general, you might want to check out their blog. They've hired a new CS manager and from the comments being left on there, and here on the forums, they've been getting them out faster and more timely. If you don't know where their blog is, paniniamerica.wordpress.com. They put out weekly updates of redemptions they've received and from whom, so you can check and see if yours is in. Also, Tracy is pretty good at responding to redemption questions in posts or directing you to someone who can help you. Posted May 23, 2012 at 10:04 am | Permalink


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By thatlad Comments
Wonder if they'll do a mini series on the fallout of being on x-force. They sort of did one with Warpath early in the run where he struggled with the killing but maybe another one would work well.
Say Elixir struglling with his turning gold problems
Angel and his Archangel issues, considering how his friends (beast, psylocke) are now scared and distrustful of him.
It'd have to be Warpath, Elixir or Archangel though. As Wolverine's not bothered by the killing (and he's in enough books), X-23 is getting her own mini, Domino's a mercenary plus she's getting featured in 'sex & violence' & wolfsbane's going to be in x-factor.


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US 4721613 A Abstract A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.
Claims(1) 1. An oral delivery system for delivering a beneficial drug, the delivery system comprising:
(a) means for shielding a multiplicity of reservoirs from an environment of use having a pH up to 3.5 inclusive, including the stomach, said means a member selected from the group consisting of a cellulose acetate phthalate composition and a hydroxypropyl methylcellulose phthalate composition that substantially maintains its physical and chemical integrity in an environment having a pH up to 3.5 inclusive; (b) a multiplicity of reservoirs in the means, the reservoirs consisting essentially of: (1) a beneficial gastrointestinal administrable drug; (2) a wall surrounding the beneficial drug comprising a different composition than the means, which will composition is a member selected from the group consisting of an innocuous cellulose ester composition and an innocuous cellulose ether composition that release the beneficial drug in an environment having a pH greater than 3.5, including the intestine; and, (c) wherein, when the delivery system is in operation in (d) the environment of use having pH up to 3.5 inclusive, the delivery system maintains its physical and chemical integrity, and when the delivery system enters (e) the environment having a pH greater than 3.5, the means of the delivery system releases the multiplicity of reservoirs in response to this environment wherein the reservoirs deliver the beneficial drug over a prolonged period of time. Description This application is a continuation of U.S. patent application Ser. No. 06/448,956 filed on Dec. 13, 1982 now abandoned. This invention pertains to a novel system for delivering a beneficial drug in a selected environment of use. More particularly, the invention concerns a delivery system manufactured as a drug delivery device, and it comprises a multiplicity of tiny reservoirs containing a beneficial drug housed in a matrix formed of a pH sensitive material that releases the reservoirs in an environment having a pH of grater then 3.5. A critical and a pressing need exists presently for a delivery system that, (1) delivers a beneficial drug at a controlled rate and continuously in a biological environment having a pH of greater than 3.5 to 8.0 such as the intestine of an animal but, (2) does not deliver the drug in a biological environment having a pH of 1.0 to 3.5 inclusive, such as the stomach of an animal. The need arises because often it is contra-indicated and therapeutically undesirable to deliver many drugs in the stomach, and because often it is indicated and therapeutically desirable to deliver many drugs in the intestine. That is, some drugs do not lend themselves for delivery in the stomach, while some drugs lend themselves for delivery primarily in the intestine. For example, drugs where administration in the stomach should preferably be avoided include, (a) drugs that are digested or decomposed in the acidic environment of the stomach such as the antibiotics erythromycin and carbenicillium; (b) drugs that induce nausea and vomiting such as emetine, atabrine and diethylstilbestrol; and, (c) drugs that act as stomach irritants such as chloride and iron salts, and anti-inflammatory drugs like aspirin, flufenamic acid, and phenylbutazone. For example, drugs where administration in the intestine is preferred include, (d) intestinal antihelmitics such as bephenium hydroxynaphthoate, niclosamide, piperazine, thiabendazole and dichlorophen; (e) intestinal antibacterials such as methenamine, sulphasalazine and phthalylsulphthiazole; (f) antischistomals such as niridazoli; (g) antiprotozians such as dichlorophen; and, (h) drugs where it is desirable to dispense the medication in the intestine for initial absorption in the duodenum and jejunium, such as folic acid in the normal proximal jejunum. The above presentation clearly teaches both the necessity and the urgency for a unique delivery system that substantially avoids delivering a drug in the stomach, but which delivery system can administer a drug in a therapeutically effective amount in the intestine over time. It will be appreciated by those versed in the drug dispensing art in view of this presentation, that if a delivery system is provided that can fulfill these demands, such a delivery system would have a positive value and represent also a substantial contribution to the dispensing art. Likewise, it will be appreciated by those skilled in the art, that if a delivery system is made available for releasing drug at a controlled rate over time in the intestine for achieving therapeutic levels, such a delivery system would be clinically useful in the practice of medicine. Accordingly, in view of the above presentation it is an immediate object of this invention to provide a novel and useful drug delivery system that satisfies the necessity and the urgency for a delivery system that administers drug in the intestine for obtaining better therapy in the management of health and disease. Another object of the present invention is to provide a drug delivery system having the combined effects of prompt initial drug delivery on entering into the intestine, and prolonged continuous administration of drug throughout the remainder of the intestine. Another object of the invention is to provide a delivery system for administering a drug in the intestine, which system is relatively economical in cost to manufacture, provides the physician with a dependable drug delivery means, and is well-adapted for practical and acceptable patient use. Yet another object of this invention is to provide a delivery system embodying physical-chemical properties that prevent release of drug in the stomach to reduce the risk of unwanted effects, and yet readily make available drug for absorption in the upper intestine and throughout the intestinal tract. Another object of this invention is to provide a delivery system manufactured as a drug delivery device that is simple in construction and exhibits all of the practical benefits of controlled and continuous administration of drug during its prolonged residency in the intestine for executing a therapeutic program. Still another object of the invention is to provide a delivery device comprising, (1) a matrix formed of a material that maintains its physical and chemical integrity in a first environment having a pH of 1.0 to 3.5 inclusive, and (2) a multiplicity of drug reservoirs in the matrix, which drug reservoirs are shielded by the matrix from the first environment, and released by the matrix as the devices pass into a second environment having a pH of greater than 3.5 to 8.0. These objects, as well as other objects, features and advantages of the invention, will become more apparent from the following detailed description of the invention, the drawings, and the accompanying claims. In the drawings, which are not drawn to scale, but are set forth to illustrate various embodiments of the invention, the figures are as follows: FIG. 1 is a view partly in section of a mold receiving a multiplicity of tiny reservoirs of drug from a filling hopper; FIG. 2 is a view partly in opened section of a mold containing the tiny reservoirs of FIG. 1 and receiving a pH sensitive polymer; FIG. 3 is a view of the delivery system provided by the invention; FIG. 4 is an opened-view in cross-section of the delivery system of FIG. 3 as manufactured by the processes of FIGS. 1 and 2. FIG. 5 depicts a multiplicity of tiny reservoirs, some in opened cross-section on their release from the delivery system of FIG. 4. In the drawings and the specification, like parts in related Figures are identified by like numbers. The terms appearing earlier in the specification, and in the description of the drawings as well as embodiments thereof, are further described elsewhere in the disclosure. Turning now to the drawings in detail, which are an example of a manufacturing procedure and a delivery system provided by the invention, and which examples are not to be construed as limiting, one example of the manufacturing procedure and the delivery system are seen in FIGS. 1 through 5, considered together. Turning first to FIG. 1, there is seen the first manufacturing step in the assembly line leading to the delivery system of this invention. FIG. 1 illustrates a mold 10 comprising a mold cavity 11 for receiving a multplicity of tiny reservoir 12 from reservoir feeding hopper 13. Hopper 13 feeds a sufficient number of tiny reservoirs 12 into mold cavity 11 for filling said mold cavity 11. FIG. 2 illustrates another step in the manufacture of the delivery system. In FIG. 2, mold 10 is positioned at the assembly line station for receiving from polymer feeding hopper 14, a pH sensitive polymer 15 in liquid form, that fills mold cavity 11 and forms a solid polymer matrix for tiny reservoirs 12. FIG. 3 illustrates the delivery system 20 provided by the invention, and it comprises a matrix 21 that is adapted, shaped and sized for oral admittance into the gastrointestional tract of an animal, including a human. In FIG. 4, seen in opened section, matrix 21 comprises a solid, non-toxic polymer 15, represented by solid lines, which matrix 21 houses a multiplicity of tiny reservoirs 12 for the controlled delivery of a beneficial agent over time. The polymer material 15 forming matrix 21 is pH sensitive. That is, it is inert, or maintains its physical and chemical integrity at a pH up to and including 3.5, and at a pH of greater than 3.5 it looses its physical and chemical integrity and releases tiny reservoirs 12 for them to act both independently and collectively for delivering beneficial agent to the environment of use. In FIG. 5, individual tiny reservoirs 12 are seen in detail, some in cross-section, and they comprise a core of beneficial agent 22 surrounded by a wall 23 formed of a release rate controlling material. Tiny reservoirs 12 can have wall 23 formed of a single layer, or of more than one layer 24 comprising like or unlike release rate controlling materials. The layers comprising 23 and 24 can be of the same or different thickness. Additionally, the materials forming wall 23, 24, can be selected from materials that release agent 22 by different physical-chemical mechanisms. These mechansims include diffusion, osmosis, erosion, and metabolism in an environment having a pH of greater than 3.5. Various thicknesses of wall forming materials can be used as an aid for providing additional controlled release of beneficial agent. In operation, delivery system 20 operates by maintaining its integrity in an environment having a pH of from 1.0 to 3.5 inclusive, such as the stomach, and essentially does not release tiny reservoirs 12 in this environment. On passing into an environment having a pH of greater than 3.5 to 8.0, such as the intestine, system 20 undergoes change by dissolving, dissolution, or the like, and releases tiny reservoirs 12 into the intestine. In the intestine, tiny reservoirs 12 deliver agent 22 over a prolonged period of time. In accordance with the practice of this invention, delivery system 20 comprising matrix 21 is formed of a polymer 15 that keeps its physical and chemical integrity in a biological environment having a pH of from 1.0 to 3.5 inclusive. Polymer 15 forming pH -sensitive matrix 21 is nontoxic, is physiologically inactive, and it does not adversely effect drug 22 and a host. Polymer 15 dissolves, disintegrates, degrades, hydrolyzes, solubilizes, is digested, or it undergoes like change in a biological environment at a pH greater than 3.5 to 8.0, thereby pH-releasing tiny timed reservoirs 12 into the biological environment. The product of polymer 15 produced on releasing reservoirs 12 is nontoxic, chemically inert, and physiologically inactive. In operation, matrix 21 keeps its integrity and provides structural support for reservoirs 12 during the period of time delivery system 20 is in the stomach and travels therethrough. Then, as delivery system 20 passes into the intestine, matrix 21 release reservoirs 12 for reservoirs 12 to delivery drug over the prolonged period of time reservoirs 12 travels through the intestine. Examples of matrix forming materials suitable for the present purpose include, (a) polymers having at least one acidic group that enables it to keep its integrity in a low pH environment, but releases the reservoirs in a higher pH environment, (b) polymers that undergo change in a higher pH environment by enzymes present in that environment, (c) polymer compositions comprising a polymer and another agent that promote at a higher pH the disintegration of the matrix, such as a polymer and a fat, fatty acid, wax and the like, and correspondingly the release of the reservoir, and (d) polymeric compositions comprising a polymer and agent such as a bile, cholesterol, or the like, that form complexes that disintegrate in a higher pH environment and concomitantly release the tiny timed reservoirs containing drug. Representative of polymers that keep their integrity at a pH of 1.0 to 3.5 inclusive are polyacidic polymers having acid groups in an undissociated form in this pH range, such as vinyl derivatives of partially hydrolyzed styrene-maleic anhydride copolymer, methylmethacrylate-methacrylic acid copolymer, polymethacrylic acid ester, methylacrylate-methacrylic acid ester, partial alkylene glycol ether esters of C1 to C4 alkyl acrylate unsaturated carboxylic acid anhydride copolymers including maleic, citraconic or itaconic carboxylic acid anhydride, and the like. Representative of additional polymers that keep their integrity at a pH of 1.0 to 3.5 inclusive, are cellulose carboxylic acid esters, cellulose carboxylic acid ethers, such as cellulose ethyl phthalate, cellulose acetate phthalate, starch acetate phthalate, amylose acetate phthalate, hydroxypropyl methylcellulose phthalate, alkali salts of cellulose acetate phthalate such as sodium salt cellulose acetate phthalate, alkaline earth salts of acidic cellulose esters such as calcium salt of cellulose acetate phthalate, ammonium salts of acidic cellulose esters such as ammonium salt of hydroxypropyl methylcellulose phthalate, cellulose acetate hexahydrophthalate, hydroxypropyl methylcellulose hexahydrophthalate, and the like. Representation of other polymers and polymer compositions comprising at least two ingredients operable for the present purpose of keeping their integrity in a pH range of 1.0 to 3.5 inclusive, are polymers such as shellac, ammoniated shellac, formalized gelatin, polyvinyl acetate phthalate, polyvinyl acetate hydrogenphthalate, and the like; and polymer compositions such as a mixture of hydroxypropyl methylcellulose phthalate and triacetate glycerol in a weight to weight ratio of 99 to 1, shellac-formalized gellatin composition, styrene-maleic acid copolymer dibutyl phthalate compositions, styrene-maleic acid polyvinyl acetate phthalate, shellac stearic acid, and the like. The matrix forming polymer compositions can contain small amounts, about 0.01 to 3 weight percent, or slightly more of a plasticizer such as esters of saturated and unsaturated fatty acids, of hydroxy carboxylic acids with ols such as alcohols and clycols, mono and draikyl phalates, and the like. Also, the polymeric composition can include a small amount, about 0.01 to 3 weight percent, or slightly more, of a filler such as carbon, talc, waxes, and the like. The matrix forming polymeric compositions can include also a binder such as sucrose, gelatin, gums, polyvinylpyrrolidone, polyethylene glycol, and the like. Matrix 21 comprising polymer 15 and tiny timed release reservoirs 12 can be made by conventional manufacturing methods. These methods include solution forming and compression forming processes. In the solution forming process, polymer 15 is mixed with a solvent and poured into mold cavity 11 containing reservoirs 12. Then, the solvent is stripped from mold cavity 11 by heat, vacuum, air blowing, or the like, causing polymer 15 to solidify yielding matrix 21 with reservoirs 12 releasably contained therein. Solvents operable for this purpose include methanol, ethanol, acetone, methanol-ethycelloslove, alcohol-acetone, methylene-chloride, methylene chloride-ethanol, methylene chloride-acetone; and the like. Examples of polymer 15 and a solvent combination are polyvinyl acetatephthalate and acetone, methylacrylate-methacrylic acid copolymer and acetone, polyacrylic acid ester and acetone, hydroxypropyl methylcellulose phthalate and acetone, hydroxypropyl methylcellulose phthalate and methanol-acetone, hydroxpropyl methycellulose phthalate and ethanol-acetate, cellulose acetate phthalate and acetone, cellulose acetate phthalate and methanol, 2-methyl-5-vinylpyridine methacrylate-methacrylic acid copolymer and ethanol, and the like. The compression forming process is carried out by charging mold cavity 11 containing reservoirs 12 with polymer 15, or polymer composition 15 in powdered, particle, or like form, and then mold cavity 11 ingredients are compressed comparatively hard to form matrix 21 containing reservoirs 12. The term hard as used for the present purpose denotes a delivery system that keeps its physical and chemical integrity in the low pH range, thereby delaying release of the reservoirs and in vivo availability of the medicament until the delivery system passes into the higher pH biological environment. Matrix 21 can be formed by conventional compression machines such as Noyes, Stokes, Manesty machines, and the like. The pressure force applied to form the matrix-reservoir delivery system has a hardness of at least 4 kilograms, kg. More preferrably, the force is from 6 to 20 kg, and in a presently preferred embodiment, a force of 15 to 20 kg is applied over the surface of the ingredients in mold cavity 11. The force used is sufficient to minimize possible premature swelling of delivery system 20 in the low pH environment and it substantially prevents the passage of a low pH fluid into the delivery system. It is also presently preferred embodiment, that reservoirs 12 be disposed in mold cavity 11 such that polymer 15 forms an exterior perimeter to lessen reservoirs 12 contact with the exterior of matrix 12 for essentially eliminating premature release of reservoirs 12 and delivery of medicament 22. Generally, delivery system 20 can have any operable shape corresponding to the shape of the die, such as square, rectangle, round, oblong and the like. The compression process used by the invention provides advantages, such as a solvent is not needed to compress the matrix, it provides a system having a uniform release of reservoirs in the higher pH environment, tacky powdered polymer can be used as an aid in compressing the matrix, and the like. Tiny reservoirs 12 used for the purpose of this invention provide for the controlled delivery of drug 22 over a prolonged period of time. Tiny reservoirs 12 comprise a drug 22 surrounded by a wall 23 of a drug release rate controlling material that delivers drug 22 in the biological environment having a pH of greater than 3.5 to 8.0. The prolonged period of time for the purpose of this invention corresponds to the period of time reservoirs 12 are in this environment. The materials forming wall 23 are in a presently preferred proviso different materials than the materials forming matrix 21, and they can be selected from materials that release drug 22 by different physical-chemical mechanisms in a biological enivornment having a pH of greater than 3.5 to 8.0. These mechanisms include erosion, diffusion, osmosis, metabolism, and the like. Wall 23 can have various thicknesses and layers as an additional aid for providing timed release of drug 22. Wall 23 of tiny reservoirs 12 surrounding drug 22 can be a wall-forming composition consisting essentially of a fatty ester mixed with a wax, such as a triglyceryl ester selected from the group consisting of glyceryl distearate, glyceryl tristearate, glyceryl monostearate, glyceryl dipalmitate, glyceryl tripalmitate, glyceryl monolaurate, glyceryl didocosanoate, glyceryl tridocosanoate, glyceryl monodocosanoate, glyceryl monocaprate, glyceryl dicaprate, glyceryl tricaprate, glyceryl monomyristate, glyceryl dimyristate, glyceryl trimyristate, glyceryl monodicenoate, glyceryl didecenoate and glyceryl tridecenoate. The was included in the wall forming composition is a member selected from the group consisting essentially of beeswax, cetyl palmitate, spermacetic wax, carnauba wax, cetyl myristate, cetyl palmitate, cetyl cerolate, stearyl palmitale, stearyl myristale, and lauryl laurate. The wall forming composition comprising the ester and the wax can be coated around the drug by using an organic solvent such as a member selected from the group consisting of carbon tetrachloride, chloroform, trichloroethylene, ether, benzene, ethyl acetate, methyl ethyl ketone, isopropyl alcohol, and the like. The fatty esters, waxes, solvents and procedures for making tiny reservoirs that slowly disintegrate and continuously provide drug over a period of 10 to 12 hours are disclosed in U.S. Pat. No. 2,793,979. Wall 23 of tiny reservoir 12 in another embodiment is formed of an osmotic wall forming material that releases drug 22 at a controlled rate by the process of osmotic bursting over time. Drug 22 in this embodiment is present in the form of an osmotic solute, such as a therapeutically acceptable salt, and it exhibits an osmotic pressure gradient across wall 23 against an external fluid. The membrane material used to form wall 23 is permeable to the passage of an external fluid and substantially impermeable to the passage of drug 22. Typical material includes a member selected from the group consisting of cellulose ester, cellulose ether, cellulose acylate, diacylate, cellulose triacylate, cellulose acetate, cellulose diacetate, cellulose triacetate, cellulose acetate having a degree of substitution, D.S. up to 1 and an acetyl content of 21%, cellulose diacetate having a D. S. of 1 to 2 and an acetyl content of 21 to 35%, cellulose triacetate having a D. S. of 2 to 3 and an acetyl content of 35 to 44.8%, cellulose acetyl propionate, cellulose acetate butyrate, and the like. The osmotic wall can be coated around the drug in varying thicknesses by pan coating, spray-pan coating, Wurster fluid air suspension coating and the like. Wall 23 is formed using organic solents, including those mentioned above, and solvent systems such as methylene chloride-methanol, methylene chloride-acetone, methanol-acetone, ethylene dichloride-acetone, and the like. Osmotic wall forming procedures are disclosed in U.S. Pat. Nos. 2,799,241; 3,952,741; 4,014,334; and 4,016,880. Wall 23 in another embodiment can be made of a drug release rate controlling material that releases drug by the process of diffusion. That is, drug 22 dissolves in wall 23 and passes through wall 23 at a controlled rate over time to the biological environment having a pH of greater than 3.5 to 8.0. Exemplary materials useful for forming a diffusional wall include ethylene-vinyl acetate copolymer, ethyl cellulose, polyethylene, cross-linked polyvinyl pyrrolidone, vinylidene chloride acrylonitrile copolymer, polypropylene, silicone, and the like. The wall can be applied by the techniques described above, and materials suitable for forming wall 23 are described in U.S. Pat. Nos. 3,938,515; 3,948,262; and 4,014,335. Wall 23 in another embodiment can be made of a biolerodible material that bioerodes at a controlled rate and release drug 22 to a biological environment of use having a pH of greater than 3.5 to 8.0 Bioerodible materials useful for forming wall 15 include polyvalent alkali mobile cross-linked polyelectrolytes, polycarboxylic acid, polyesters, polyamides, polyimides, polylactic acid, polyglycolic acid, polyorthoesters, and polycarbonate polymers that erode in the pH of greater than 3.5 to 8.0. The polymers and the procedures for forming wall 23 are disclosed in U.S. Pat. Nos. 3,811,444; 3,867,519; 3,888,975; 3,971,367; 3,993,057; and 4,138,344. In the specification and the accompanying claims the term drug denotes pharmacologically beneficial substances that are absorbed in an intestinal environment by one or more of the following transport mechanisms: active transport, passive transport, pore transport, or facilitated transport to produce a local or systemic effect in animals. The term animals as used herein includes warm-blooded mammals such as humans. The beneficial drug that can be delivered in a biological environment having a pH greater than 3.5 to 8.0 are drugs that act on the central nervous system, depressants, hypnotics, sedatives, psychic energizers, tranquilizers, muscle relaxants, antiparkinson, analgesics, anti-inflammatory, hormonal, contraceptives, sympathomimetics, diuretcis, antiparasites, neoplastics, hypoglycemics, electrolytes, cardiovascular, anthelmintics, and the like. Exemplary drugs that are administered in an environment having a pH greater than 3.0 to 8 include hycanthone, aminophylline, aminosalicyclic acid, chymotrypsin, sulfoxone sodium, diethylstilbestrol, erythromycin estolate, erthromycin, orenzyme, carbomycin, riboflavin, thiamine, vitamin D2, vitamin D3, vitamin B12, nitrogen mustard derivatives, phenylbutazone, acetysalicylic acid, helmintheasis xanthones, helminthiasis thioxanthones, narcotics morphine and codeine, derivatives of pyrimedines including 5-fluorouracil and 5-bromouracil, quaternaly ammonium compounds including benzomethamine, oxyphenonium, hexamethonium, and tubocurarine, atropine, and the like. The beneficial drugs are known in the art in Pharmaceutical Sciences, by Remington, 1980, published by Mack Publishing Co.; Physicians' Desk Reference, 36 Edition, 1982, published by Medical Economics Co.; and, Medicinal Chemistry, 3rd Edition, Vol. 1 and 2, by Burger, published by Wiley-Interscience Co. Drug 22 can be present in tiny reservoirs 12 in various forms, such as uncharged molecules, molecular complexes, as therapuetically acceptable addition salts such as hydrochlorides, hydrobromides, sulfates, oleates, and the like. For acid drugs, salts of metals, amines, organic cations, quaternary ammonium salts can be used. Derivatives of drugs such as esters, ethers and amides can be used. A drug that is water insoluble can be used in a form that is a water soluble derviative thereof to serve as a solute, and on its release from the delivery system is converted by enzymes, hydrolyzed by body pH, or other metabolic processes to the original biologically active form. The amount of drug present in a tiny timed reservoir generally is about 10 ng to 25 mg. For some drug, a slightly higher amount may be present in the reservoir. The number of tine timed reservoirs present in a delivery system is about 10 to 1000, and preferably for an oral delivery system about 100 to 150. The tiny reservoirs comprising the wall and the inner drug core have a diameter of about 100 microns, and in a presently preferred embodiment a diameter of about 2000 microns. For oral use, the delivery system comprising the matrix and the tiny reservoirs homogenously or heterogenously housed therein, can have conventional shapes such as round, oval and the like. The delivery system can have a diameter of 4 mm to 15 mm, and the like. The following examples will serve to further illustrate the invention. A delivery system manufactured and sized, shaped and adapted as an orally administrable tablet containing tiny reservoirs of a sympathomimetic drug is prepared as follows: first, powdered drug is mixed with sucrose and the blend passed through a 15 to 30 mesh screen to yield a multiplicity of cores of drug. Then, a drug release rate wall forming composition comprising 85% glycerol monostearate and 15% beeswax in warm carbon tetrachloride is spayed over the cores in a revolving coating pan until a wall is formed that surrounds individually and separately each drug core. Next, the coating solvent is stripped from the tiny reservoirs, and a series of mold cavities are charged with 50 tiny reservoirs and 200 mg of a matrix forming pH sensitive powdered polymer. The matrix forming polymer, slightly tacky cellulose acetate phthalate, is a different polymer than the polymer composition used to form the wall of the reservoirs. Finally, the filled mold cavity is pressed under a pressure of 18 kg to yield the delivery system. Another drug delivery system is provided by coating a drug core, for example, procainamide hydrochloride, in a fluid air suspension with a wall forming compositions of ethyl cellulose in ethanol to surround the drug core with ethyl cellulose, to yield the tiny reservoirs. After the solvent is vacuum stripped from the tiny reservoirs, the reservoirs are blended with ground tacky shellac and pressed into an oral tablet. The aboce manufacture can be repeated by replacing the ethyl cellulose and ethanol with cellulose acetate having an acetyl content of 32% and methylene chloride-methanol solvent and then dispersing the tiny reservirs in a pH releasable matrix comprising sticky polyvinylacetate phthylate; or, by applying a bioerodible wall of poly(2,2-dioxo-trans-1,4-cyclohexane dimethylene tetrahydrofuran) around the drug core. The latter polymer is applied by heating the polymer to 80�-90� C., and then dispersing a multiplicity of tiny reservoirs in matrix forming polyvinylacetate phthalate. In another example, a delivery system is made by first preparing sustained intestinal release tiny reservoirs by blending 400 ml of ethyl cellulose-water, 70:30% solution, with 375 g of aminophylline, 150 g of mannitol and 475 g of magnesium stearate, and the blend kneaded and passed through an extrusion granulation machine. After drying at 115�-120� F., the reservoir forming drug cores are passed through a 20 mesh screen and then coated with a wall of ethyl cellulose in an air suspension machine to yield the tiny reservoirs. The number of coats surrounding the drug core is variable, usually 1 to 10 separate coats are used for the present purpose. Next, a multiplicity of reservoirs are blended with very slightly aqueous moist granulated sodium hydroxypropyl methylcellulose phthalate and the blend fed into the mold cavity of a tablet compressing machine. Then, the blend is compressed under a pressure head of at least 16 kg/cm2 and under vacuum to yield the delivery system. Other drug delivery systems are made by spraying nonpareil cores with an erodible, non-toxic adhesive and then dusting with drug. The drug-coated core is coated with an appropriate number of non-toxic intestinal drug release rate polymer composition to yield the tiny reservoirs. The number of polymer composition coating is variable, usually at least 1 to 20 separate coats. Finally, the tiny reservoirs are housed in a pH sensitive reservoir. The tiny reservoirs also can be made from a core carbohydrate, such as sucrose, dusted with a mixture of talc, starch and galactose, moistened with distilled or deconized water, then dusted with the desired medicinal, such as the antibiotic erythromycin, and then coated with a reservoir wall forming polymer composition. The reservoirs are dried and then suspended in a solid matrix selected from the group consisting of a polymer composition of at least two wall forming members such as shellac and ammoniated shellac, polyvinyllactate, phthalate, a blend of polyvinyllactate phthalate and polyvinyllactate phthalate, and the like. It will be appreciated by those versed in the delivery art the present invention advances the state-of-the-art by providing (a) a delivery system comprising tiny reservoirs that release drug in an environment having a pH greater than 3.5, which tiny reservoirs do not require an additional coat that prevents their releasing drug in an environment having a pH up to 3.5, inclusive, as they are individually housed in an environment protective matrix; (b) by providing a delivery system that substantially protects the drug from the digestive processes of the stomach; (c) by providing a delivery system that substantially eliminates irritating a mucous membranes of the stomach by shielding the drug from contact with the membranes; (d) by providing a delivery system that delivers drugs to the intestinal tract in their therapeutically active forms at a controlled and constant rate of delivery throughout the intestinal tract during the period of time the tiny reservoir traverse the intenstine, and correspondingly establishing in an animal recipient drug blood drug levels exhibiting a decrease in peak and valleys of drug which may lead to ing a decrease in peak and valleys of drug which may lead to unwanted results; and (e) by providing a delivery system that embodies delayed onset of delivery at a later time with the capability of dispersing drug delivered over the intestinal tract to enhance drug absorption and/or local treatment of the color. Also, it will be understood by those knowledgeable in the delivery art that many embodiments of this invention can be made without departing from the spirit and scope of the invention, and the invention is not to be construed as limiting, as it embraces all equivalents thereof. Patent Citations
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duti is a command line utility capable of assigning default applications for document types, called Uniform Type Identifiers, on Mac OS X.
Tags | Utilities Systems Administration Mac OS X |
Licenses | Public Domain |
Operating Systems | Mac OS X |
Implementation | C |
Release Notes: This release adds -s to set default handlers from command line arguments. It adds -x to print default application information for a given file extension. Before setting a default handler for a UTI, check to make sure the UTI conforms to a system UTI hierarchy.
No changes have been submitted for this release.


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Payment Systems, Inside Money And Financial Intermediation
Free registration required
Executive Summary
The authors assess the impact of introducing an efficient payment system on financial intermediation. Two channels are investigated. Innovations in wholesale payments technology enhance the security and speed of inside money as a payment medium for customers and therefore affect the split between holdings of cash (outside money) and holdings of deposits (inside money). Second, innovations in wholesale payments technology help establish well-functioning interbank markets for end-of-day funds. This reduces the need for banks to hold excess reserves and thus helps credit creation.
- Format: PDF
- Size: 568.4 KB


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I'm looking for a plush turtle from 1991 that winds up and plays Brahm's Lullaby. It has very light pastel colors (blue, green, pink and yellow shell, green limbs and head, and a white under belly. The material feels like it may have been super soft, but it's somewhat rough now due to age.
This was my first stuffed animal. Its lullaby sent me to sleep for years. My Labrador chewed the turtle's face off, and I can't afford to get him repaired. Even at age 22, I would do anything to have my turtle back.
If you can help Jordyn find this 90's Multi-color Pastel Turtle Windup Brahms, CONTACT US, including the POST CODE #25828, but if possible – PLEASE USE THE COMMENT BOX.
Searching for a toy – Originally posted [postdate format="M j, Y"]
Please be sure you Contact US with an email address that is correct, and that you will be using for a long time!! We can't help you if we can't contact you!!


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Piazza Navona is one of the most famous areas in the city center and it is filled with boutiques, cafes restaurants and bars. It is also right around the corner from Campo di Fiori and the Pantheon. When people say they are going to meet you somewhere in the center, this is usually where they have in mind.
This charming apartment is located in a stunning traditional Rome building that is both bright and spacious, creating a welcoming space. The living room features parquet floors, high ceilings with wooden beams and large windows that allow in plenty of natural light. The room is furnished with a sofa bed, coffee table, dining table with seating for all guests and television. The kitchen is fully equipped with everything needed to prepare meals in the apartment.
The bedroom is stylishly furnished and features a double bed and ample storage space as well as an ensuite bathroom. The main bathroom features a shower, toilet and sink. The apartment also features a private paved garden, perfect for that morning coffee or evening glass of wine.
Just a short walk away is the famous shopping street Via dei Giubbonari which leads straight on to the renown Campo De Fiori. The apartment is within walking distance of the Colosseum and Foro Romano in the heart of the old Roman city centre. The Colosseum, opened in 80 AD, is perhaps the most iconic of sight of Rome. For close to 2000 years the Amphitheatre has captured the hearts and minds of locals and tourists alike and is often considered one of the greatest works of Roman architecture and engineering. The Foro Romano is equally impressive, considered the oldest part of the city and home to several important Government buildings dating from the height of the Roman Empire. Spending a few hours walking around the Forum gives you an idea of the just how impressive the city would have been 2000 years ago. Within walking distance of the apartment are some of the city's finest attractions including the stunning Trevi Fountain, the Spanish Steps, the Piazza del Popolo and the foot the Pantheon. The district also features an array of high quality restaurants and wine bars, the ideal place to spend some time after enjoying the sights of the city. If you do need to travel further afield, the apartment is well served by the Metro.Check-in: | From 14:00 Check-out: Until 10:00 |
Payment: |
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Internet: | Wi-Fi Internet free of charge in all rooms and general areas (lobby/reception etc.) |
Parking: | Public parking |
Pet policy: | Pets allowed Free of charge |
Rooms: | 1 |
General facilities: |
Extra common areas: |
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Please note that a non-refundable deposit will be charged on the given credit card and the remaining balance will have to be paid in cash at the time of check-in. The keys will be handed once the total amount of the reservation is paid. |
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Topics :: HIV prevention
1 thru 10 of 306 Stories
Three Artworks Auctioned on Feb. 1 to Benefit AIDS Help Key West
As a part of the celebration of their 25th Silver Anniversary, AIDS Help Art Auction's Committee invited three outstanding artists to submit a piece as a commemoration of the event. These works are to be raffled at the Art Auction on February 1.
Jeweler Harry Winston Provides Corporate Sponsorship to amfAR
Building on its legacy of philanthropy and charitable giving, international fine jeweler and watchmaker, Harry Winston, Inc. announced a groundbreaking new partnership with amfAR, The Foundation for AIDS Research.
GMHC and Monster Cycle Host 4th Annual Indoor Cycling Event
On Saturday, Jan. 24, Gay Men's Health Crisis (GMHC) and The Monster Cycle will host a three-hour indoor cycling fundraiser to benefit GMHC's programs.
Ask the Doc: The Hidden Risks of HIV Testing
In this installment of Ask the Doc, Dr. Howard Scheiner looks at what you really need to do to keep yourself healthy and disease-free.
Fighting AIDS: How Close Are We to Getting to Zero?
Eric Brus of AIDS Action gives a comprehensive look at what ASOs across the world are doing to "end the epidemic" of HIV/AIDS.
Top HIV Stories of 2014
This was a banner year for HIV, with many inspiring stories about advances in rights for people living with HIV in prisons, health care and even in remembering their legacies.
Top HIV Breakthroughs of 2014
In 2014, "cure" was the buzzword, with doctors across the globe racing to build on the success of The Berlin Patient.
Top PrEP Stories of 2014
This year saw the advent of Pre-Exposure Phrophylaxis for HIV with Truvada, a controversial new tool in the fight against AIDS. Research shows that when taking properly, PrEP may be up to 99 percent effective in preventing new infections.
The Top 15 HIV Fundraisers of 2014
Here's a list of 2014's top 15 HIV fundraisers. From Los Angeles to New York, see how these groups raise funds to help their clients living with HIV/AIDS.
The Beehive
Although it appears as if our shortcomings ares being exhibited, it is clear that a large majority of screened participants have been tested for HIV in their lifetime, which indicates San Diego's success with HIV testing campaigns.
1 thru 10 of 306 Stories


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Interview with Dorian Yates
Long interview where he talks about nutrition, training, steroids and so on.
Need to set aside some time to watch this. The short bit a skipped through sounded good. Great find Swedish.
Thanks for posting.
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Golf Ball Drop
A Golf Ball Drop is an exciting way to raise funds for your organization or charity. This is an increasingly popular way to host a raffle at your next function. HeliStream will gather the golf balls that you have pre-sold and while hovering over the designated hole at your pre- selected golf course, drop all of them… attempting to get a hole-in-one. The owner of the golf ball that lands in the hole, will win the prize! A guaranteed crowd pleaser, HeliStream performs many golf ball drops each year at special events and golf tournaments.
For more information on hosting a golf tournament with a golf ball drop, please call Mike McChristie at Tijeras Creek Golf Course. You can visit their website at www.tijerascreek.com.
Robinson R22 (holds up to 500 golf balls)
Robinson R44 (holds up to 1500 golf balls)
AStar (holds up to 5000 golf balls)
*All aircraft have a 1hr. minimum


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The Hawaii Supreme Court agreed today with a woman who said the city and county of Honolulu should have completed its archeological surveys before starting any construction on its $5.26 billion heavy rail project.
The city performed some of this work with the intention of doing more later, and is already building columns for the 20-mile long rapid transit system.
Paulette Kaleikini is a descendent of Native Hawaiians, and in her legal challenge to the Supreme Court said the city first should have accounted for burial grounds in downtown Honolulu and Kakaako.


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After watching American Psycho over the course of two evenings, I had to ask myself why? Why was such a film made? What started out as a rather engaging look into the mind of a sociopath ended up more like a weird video game than a movie headlining staring a talent like Christian Bale (The Machinist, Batman Begins).
Directed by Mary Harron (The Notorious Bettie Page) American Psycho is not as bloody as I initially thought it would be, but it is a violent film. Bale portrays Patrick Bateman a man seemingly in control of his ordered life. He tries hard to fit into society, but his mind is slowly slipping away; you see he likes to murder people in a variety of different ways. At first hes careful and thoughtful about who, how, where, and when he murders, but half way through the film, he loses it and starts to get sloppy; enter William Dafoe (Spider-Man, Platoon) as Detective Kimball; he is investigating the disappearance of one of Batmans victims.
After all was said and done, I wasnt even entertained by American Psycho, more like repulsed, and again I ask why?
Viewing Format: DVD
Video Occasion: None of the Above
Suitability For Children: Not suitable for Children of any age
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This American Life
This American Life is best described as a movie for radio. There are people in dramatic situations. Things happen to them. There are funny moments and emotional moments and—hopefully—moments where the people in the story say interesting, surprising things about it all. |
Daily two-hour series of evocative, ground-breaking music seamlessly bridges new instrumental, world fusion, new acoustic, impressionistic jazz and inventive vocal styles. |
A new project, called Detroit4Detroit, is launching in the city. It's part of the national organization, Citizen Effect. Craig speaks with Nicole Schneidman, a manager for the organization, and Eric Moss, the local program manager and Citizen Effect fellow. Detroit4Detroit is said to be "a movement of 150 passionate citizens, each committed to leading the fundraising for a community project in Detroit. If you are ready to have a direct impact on the city you love, we have the tools and support for you to bring your friends, family and social network together for the Detroit cause you believe in."
Click on the link to listen to this interview and feel free to add your comments below...
Image courtesy Detroit4Detroit.


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Microsoft's Office 365 Prepping for June Launch
Microsoft's Office 365 Prepping for June Launch
Nicholas Kolakowski
Posted 2011-06-06
Microsoft is prepping Office 365 for a June launch, according to comments from CEO Steve Ballmer. Media has received invites to an Office 365 event in late June.
Expectations are high that Microsoft will launch Office 365 at the end of June. The cloud-based productivity software represents Redmond's current best chance at driving back the threat presented by Google Apps and similar platforms. The company has sent media invitations to a June 28 event in New York City, where Microsoft CEO Steve Ballmer will apparently take the stage to talk Office 365. The actual venue is the Skylight Soho, also the site of Microsoft's Windows 7 launch in October 2009.
While the invite is coy about this being Office 365's actual launch-"Be a part of the live audience in New York City with Microsoft CEO Steve Ballmer to hear the latest about Office 365" is the closest it comes-the choice of venue, combined with Ballmer's presence, suggests the release is indeed close at hand.
"We're pushing hard in the productivity space," Ballmer told an audience during a May 26 speech in Delhi, India,
according to a transcript released by Microsoft
. "We'll launch our Office 365 cloud service, which gives you Lync and Exchange and SharePoint and Office and more as a subscribable [sic] service that comes from the cloud. That launches in the month of June." Microsoft launched Office 365's public beta in June. The platform links together Microsoft Office, SharePoint Online, Exchange Online and Lync Online, all for a starting price of $6 per user per month. Microsoft is also offering an Office 365 Marketplace with productivity apps and professional services. Office 365 is essentially a rebranding of the company's BPOS (Business Productivity Online Suite), which bundled products such as SharePoint Online. That massive public beta followed a limited beta launched in October 2010. Office 365 represents yet another aspect of Microsoft's "all in" cloud strategy, which for the moment centers on pushing a variety of cloud-based IT services to corporations. The push comes just as Microsoft faces competition not only from Google, which wants to secure large IT contracts with corporations and government entities, but also upstarts such as Salesforce.com, which have taken to attacking Microsoft's desktop-centric software offerings as a herd of hopelessly outdated dinosaurs.
Microsoft is arguing that Office 365 will ultimately save companies the money and headaches associated with maintaining on-premises servers and other IT infrastructure. That subscription model also ensures Microsoft a steady stream of month-over-month revenue. But in order to seize that business market, Microsoft will need to face down Google, which is devoting similarly enormous resources to developing and deploying its own cloud-based offerings for small and midsize businesses, as well as the enterprise.
Nicholas Kolakowski is a staff editor at eWEEK, covering Microsoft and other companies in the enterprise space, as well as evolving technology such as tablet PCs. His work has appeared in The Washington Post, Playboy, WebMD, AARP the Magazine, AutoWeek, Washington City Paper, Trader Monthly, and Private Air. He lives in Brooklyn, New York.
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Goodreads helps you keep track of books you want to read.
Start by marking "The Prince of Paradise: The True Story of a Hotel Heir, His Seductive Wife, and a Ruthless Murder" as Want to Read:
The Prince of Paradise: The True Story of a Hotel Heir, His Seductive Wife, and a Ruthless Murder
John Glatt
A MILLIONAIRE PLAYBOYBen Novack, Jr. was born into a hotel empire, Miami's lavish Fontainbleau. But his luxurious, celebrity-studded lifestyle would ironically end in another hotel room—where the police found him bound up in duct tape, beaten to death.A HISTORY OF VIOLENCESeven years earlier, police found Novack in an eerily similar situation—when his ex-stripper wife Narc
Paperback, 464 pages
July 29th 2014
by St. Martin's True Crime
(first published June 26th 2012)
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I was fascinated by the story of the Fountainebleau Hotel. I remember going there as a kid in the 50's. It was an amazing place. It was the coolest place I'd ever seen. Right away I wanted to spend the rest of my life in a hotel. But I didn't. To this day, however, there's nothing like spending time in a reaaaly nice hotel. Of course, I hardly leave home. It's got everything I need, but I sure do miss the helpful fellows in white coats bringing stuff and cleaning up.
The guests at the hotel seeme ...more
The guests at the hotel seeme ...more
If it were possible, I would have given this zero stars. It took a semi-interesting true crime piece, stripped it of all interesting features and substituted lurid ones, and then proceeded to be one of the worst-edited books ever. Major characters names are misspelled, often being spelled differently in the same paragraph. Pieces of the story repeat over and over. The book ends abruptly. Awful.
I found this book interesting. The son of the the builder and owner of the famous Fountainbleu Hotel in Miami grows up indulged in all things. As an adult, he was more than capable of business affairs and became wealthy in his own life. Because of his lifestyle, he never fully matured and was prone to tantrums. He was unable to maintain healthy relationships with his friends and in his love life. Although he was married to his last wife, Narcy, for a long time, the marriage was tumultuous and of
Wow! This is a true story? It just proves one more time that the truth is certainly stranger than fiction (unless you are Neil Gaiman). This is an engrossing book, these people are not very nice, even most of the victims. There is some interesting history and lots of evidence of corruption, greed and downright disregard for civility. Wealthy people behaving badly could be the subtitle but the investigative reporting is well done. A little dry at times and seemingly too knowledgeable at others, i
I grew up in Miami Beach and enjoyed the first 150 pages or so about the Fontainebleau in the 60s and 70s. But then the book becomes excruciatingly detailed about Novack Jr. and his wife, repetitive, endless. Maybe true crime aficionados like it that way, but it was much more than I cared to know. A much more enjoyable book about the hotel was Everything by Design, by Alan Lapidus, whose father designed the hotel.
Ben Novack, Jr., son of the founder of the world famous Fountainebleau Hotel in Miami Beach, was raised in a glamorous lifestyle surrounded by musicians and movie stars, but pretty much ignored by his parents. When his father lost the hotel due to finances, Ben became wealthy in his own right. Unfortunately, he was a really peculiar guy with an obsession with all things related to Batman, a passion for the material trappings of wealth, strange sexual fetishes, and a manipulative, evil wife who w
I am in quite the book funk lately- now having started and put down a THIRD book this year.
I loved Magic City on Starz and the beginning of this book is like watching the show all over again (clearly the Fountainbleu's history is what the show was based on) However, this book was SO poorly written. Entire thing was he said/she said- never any actual author interviews with any of the books characters. I felt like he was retelling the 2001 Ocean Drive interview and excerpting parts of Steven Gaine ...more
I loved Magic City on Starz and the beginning of this book is like watching the show all over again (clearly the Fountainbleu's history is what the show was based on) However, this book was SO poorly written. Entire thing was he said/she said- never any actual author interviews with any of the books characters. I felt like he was retelling the 2001 Ocean Drive interview and excerpting parts of Steven Gaine ...more
Though I live in the area and am certainly familiar with the famous hotel, now a converted resort residence, I was not aware of the story behind the murders. The book presents a fascinating history of the founding of the Fontainebleu Hotel by Ben Novack and the struggles to keep it in the family.
Ben Novack Jr. the son and mother are murdered by his second wife and her brother in an attempt to take over what remained of the family fortune. Ben Jr. despite his nature as a spoiled only child did su ...more
Ben Novack Jr. the son and mother are murdered by his second wife and her brother in an attempt to take over what remained of the family fortune. Ben Jr. despite his nature as a spoiled only child did su ...more
I would give this book a zero if I could. The first part of the book giving the history of Miami Beach and how the hotel business was developed was very interesting. Then we get to Jr. The book became predictable and reading about this dysfunctional family was tedious and boring. I did not finish the book.
parent ben and maxine novack built world famous hotel, early 50s in miami florida. many stars of that era performed and helped make place famous. the son ben jr. grew up in hotel in luxury suite on 17th floor. he could do anything he wanted as staff was afraid of father. once went into kitchens and ordered head chef to give him ice cream. chef told him to have someone else get it for him. kid told chef he was fired and when daddy said if kid fired him then he was fired. this was chef in charge o
As my first true crime read, I have to say it was very engrossing to read. Also it made me sad to think that they're are some serious twisted people out there that would do almost anything to get money and riches. Was definitely impressed with John Glatt's novel that I'm definitely interested to see what else he has written.
Glatt is a polished and evocative writer, and this book shines in the first third, when giving the colorful history of the rise of Miami Beach and the Fountainbleau, as well as the downfall of the Novack family. But once it gets into the nitty gritty of the crime, the book loses its magic and its momentum. All the characters are so despicable, there's no one to root for. It's just a tragic tale of ugly, greedy people doing ugly, greedy things - both victims and perpetrators alike.
Jun 06, 2013
added it
Very compelling story that reads like fiction, but is unbelievably true. The book is at its best when focusing on the history of Miami Beach's iconic Fontainebleu Hotel, and its owners Ben & Bernice Novack. When it shifts into the murders of Bernice Novack and her son, Ben Jr., it seems that the book needed one more go-round with editing. Still enjoyed it, though, and would absolutely recommend it to aficianados of true crime.
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English-born John Glatt is the author of Lost and Found, Secrets in the Cellar, Playing with Fire, and many other bestselling books of true crime. He has more than 30 years of experience as an investigative journalist in England and America. Glatt left school at 16 and worked a variety of jobs—including tea boy and messenger—before joining a small weekly newspaper. He freelanced at several English
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Join the Global Quality Community in celebrating World Quality Month in November! World Quality Month provides a platform for acknowledging the efforts and accomplishments of quality and all who work to make it happen. This is a time to celebrate — a time to showcase the advancements and valuable quality contributions in businesses, communities, and institutions. Together — through our collective passion for improvement — we will raise the voice of quality worldwide. Learn more >
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I'm punkrockchic9
This was from Maybury Park the other day. I can't wait to go back!
They both wanted to ride the bike. This was their compromise.
This boy ❤
Ahoy matey's! Is mommy guilt normal? Cuz if it is, count me in. If it isn't, count me crazy. The amount of guilt I feel on a daily basis is ridiculous. I feel guilty when Harrison sits in the Rock and Play too long, even when he's content. I feel guilty when Franky builds Lego towers by himself while I fix lunch because I feel like I should be right by his side, building with him. I feel guilty when Marija plays with Legos because I feel like I should be teaching her about Barbie's. I feel guilty when I'm impatient, when I yell out of frustration because they didn't listen the first time, fought with each other, because they tested their limits or did something they weren't supposed to do. I feel guilty when I punish them. Does the guilt ever go away? Am I a horrible person when all I want at the end of some nights is a big friggin glass of wine instead of wanting to read a book to my kids?
He absolutely cracks me up!
He wasn't so sure about the swing. He got scared and freaked out, poor baby.
Ry with each of his babies on the days they were born. Top left is Franky, bottom left is Marija and right is Harrison. Ry had to work on Father's Day so we stayed home and had a pretty low-key day, which none of us minded. Ry and I are super low-maintenance with things like mother's/father's day, anniversaries, birthdays. We don't make a big to-do about it or get crazy gifts or anything like that and to be honest, I prefer it that way. If there's something one of us sees throughout the year that we know the other one would like, we get it even if there's no "special" occasion. Or if one of us wants something, we get it rather than waiting to give or receive it as a gift. We tell each other we love each other every day and find the time to sneak away whenever we need it even if it's not a holiday, anniversary or birthday. I like the random, unexpected, last-minute types of gifts and getaways more than the ones that are planned or expected. I hate feeling like I
to do something just because the day says so. I hate feeling pressured. So when it's an out-of-the-blue gift or getaway I appreciate it more and love that giddy feeling I get in the pit of my belly every time.
I'm having the hardest time losing the last of the baby weight and have been at a complete stand still. I'll lose a few then gain a few then lose a few then gain 'em and it's making me crazy. I only have around 5 lbs to lose to reach my ultimate goal, but my eating habits have absolutely sucked and I haven't been getting out for runs as often as I'd like. In an attempt to still be somewhat healthy while giving in to my sweet tooth lately, I've been making treats like this. Sliced bananas with a few tablespoons of Trader Joe's Cookie Butter. OMG this stuff is sinfully good. No joke. I've had a cookie butter and jelly sandwich, cookie butter mixed in my oatmeal, cookie butter with bananas and honey on crackers. You name it, I've probably had it in the last two days. I'm pretty much obsessed with Trader Joe's lately. Ry introduced me to it a few years back and we've shopped there sporadically over the years, but lately we've been doing our weekly grocery shopping there instead of making our usual Kroger or Meijer trips. I can't say I miss the other places and I'm thinking I'll be putting Trader Joe's into the same category as Target trips: better paired with a cup of Starbucks and sans children :)
Oh this bond...there is absolutely nothing better in life than this. I weaned Franky at 12 months and regretted it right after because neither of us were really ready. I let Marija decide when she was done and it was sometime around 20 months. I'll let Harrison decide as well, whether that be at 12 months or 24, it will be his choice.
I've been saying I want to get back to how I ate and worked out last year. I ate (mostly) clean and worked out no less than 5x a week. So it's funny, then, that as I was chanting it in my head this morning that I made a fairly unhealthy breakfast this morning, lol. These were potatoes that had cooked in the bottom of the pot when my MIL made her infamous meat and rice grapeleaves a few days ago. I pan-fried them in coconut oil with some chopped green peppers. Then I pan-fried some eggs in green pepper circles, topped them with white cheddar and drizzled them in sriracha sauce. It was somewhere around 450 calories and absolutely delicious.
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Occupational Therapy Assistant
Degrees & Certificates:
Course Descriptions
For course descriptions, please see the college catalog.
Contact Us:
- Career and Advising Center
ext. 2641
See also:
Occupational Therapy is a health discipline that provides services to people whose lives have been disrupted by physical injury, illness, and developmental, psychosocial, or aging-related problems. Occupational therapy means therapy that enables a person to gain the functions necessary to perform day-to-day work, self-care, and leisure activities as related to one's roles. For example, a person with a disability may need to relearn how to dress themselves, how to safely take a bus, or how to prepare a basic meal.
Ninety five percent of all Green River OTA graduates passed the National Board for Certification in Occupational Therapy (NBCOT) test in 2011. Current starting salaries usually range from $18 to $25 per hour. Many employers also offer excellent benefits.
Visit the Occupational Therapy Assistant (OTA) program site for detailed information on this exciting opportunity.
Accreditation Information:
The Occupational Thereapy Assistant Program is accredited by the Accreditation Council for Occupational Therapy Education (ACOTE) of the American Occupational Therapy Association (AOTA. They are located at:
4720 Montgomery Lane, Suite 200,
Bethesda, MD 20814-3449.
Phone: (301) 652-2682
Website: http://www.acoteonline.org
National Certification Exam
Graduates will be eligible for the national certification examination for the occupational therapy assistant administered by the National Board for Certification in Occupational Therapy (NBCOT). After successful completion of this examamination, the graduate will be a Certified Occupational Therapy Assistant (COTA).
Pass/Fail Rate
For the three most recent calendar years (2010, 2011, 2012), the performance of the graduates of the occupational therapy assistant program on the National Board for Certification in Occupational Therapy (NBCOT) certification examination was as follows:
Year | Number of program graduates | Number of first-time test takers | Number of first-time test takers who passed the exam | Percentage of first time test takers who passed the exam |
2011 | 37 | 32 | 30 | 94% |
2012 | 42 | 43 | 38 | 88% |
2013 | 41 | 42 | 38 | 90% |
Total 3 Year | 120 | 117 | 106 | 90% |
View pass rates for all OTA programs: NBCOT website.


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Kajal Exhibits Her Svelte Structure
Heroine Kajal Agarwal is the one lady who gave tough competition to other heroines in Tollywood and presently became work less as there are not much tempting offers in her kitty.
Rumors is buzzing that Kajal is giving more importance to remuneration irrespective of the story and director.Presently the lady shifted her focus into Kollywood and trying to prove her existence among Tamil audience.
Kajal is acting in a movie Named 'Jilla' and she is playing as powerful lady Cop in the movie. Here is the exclusive pic of Kajal .it's really surprising to see Kajal in a tight fitted attire which clearly reveals her curvy shapes.She wore black coloured top which is helpless to stop her forced assets. Of Course the spicy looks of the seductress and the way she bent on the vehicle is creating more heat among the viewers.
Recently Kajal expressed her desire to act in a fill length action movie and this may be the one for which she is looking for.The film, produced by R. B. Choudary under the banner Super Good Films will feature a soundtrack composed by D. Imman The film is scheduled for a release
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So right now I have 2 holsters.
I have a SERPA holster from Blackhawk that I use for being in the woods/hunting/carrying openly. But I don't want to carry openly in public so I need a concealed one.
Well, there are like no choices for a shoulder holster at Cabela's or Gander Mountain by me and I'm worried about getting one online and having it not fit me well or not fit the gun. I ended up getting this airsoft gun shoulder holster at Gander that a guy directed me to. It actually holds the gun pretty nice, but I don't care for how it fits on me. I returned it.
I then decided I'd get an OWB (I don't want IWB) that sat a bit higher so my gun would be more hidden under a shirt. Well I got some decent one for $35 but when I got home, I noticed it sat no higher really than my SERPA...so now I have to return THAT one too.
What reasonably-priced OWB holsters do you guys suggest? Preferably a clip on, so I can take it off easy when I get in the car.
What REASONABLY-PRICED shoulder holsters do you guys suggest? Many are sooo expensive. And I don't feel like spending over $30 for one (I know, that's cheap).
I carry a Ruger SR9 (which is kinda big to conceal in the first place)


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Dr. Corey L. Teigen, MD
Vascular & Interventional Radiology, Sanford Clinic Broadway
- 801 Broadway N
Fargo, ND 58102 - 1 Office Location
- (701) 234-2000
Dr. Corey L. Teigen graduated from the Johns Hopkins University School of Medicine in 1990. He works in Fargo, ND and specializes in Vascular & Interventional Radiology. Dr. Teigen is affiliated with Sanford Medical Center. He speaks English and Spanish.
Gender: Male
Years in Practice: 25 Years
Languages Spoken: English, Spanish
Medical School: Johns Hopkins University School of Medicine
Graduation Date: 1990
Hospital Affiliations: Sanford Medical Center
Specialties: Vascular & Interventional Radiology