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Publications (29)123.19 Total impact
- Hipertensión y Riesgo Vascular 07/2013; 17(7):339–340.
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ABSTRACT: Abstract In Uppsala, extensive epidemiological and clinical studies on insulin resistance and diabetes have been ongoing for the past 30 years. A prospective cohort study of men born 1920-24, living in Uppsala County, was initiated during 1969-74 (the Uppsala Longitudinal Study of Adult Men, ULSAM). Risk factors for cardiovascular disease were examined in 2,322 men, and re-examinations have been performed every 10 years. At the first follow-up, when the men were 60 years old, insulin resistance was found to be a risk factor for development of hypertension and diabetes. In addition, treatment with antihypertensive medication was an independent risk factor for development of diabetes. These findings resulted in a series of clinical studies on metabolic effects of antihypertensive agents. At the second follow-up, when the men were 70 years old, the development of hypertension and diabetes was once again in focus, but at this time, cross-sectional and prospective studies of other cardiovascular determinants, such as circadian blood pressure pattern, left ventricular geometry and function, muscle morphology, ion status, fibrinolysis and cognitive function, were also performed. The cohort has furthermore been linked to the Swedish census and hospital discharge and cause of death registries, it has been used for studies on relationships between birth weight and cardiovascular disease, and genetic analyses have been performed, taking advantage of the long observation time obtained in this cohort. The cohort is currently being re-examined for the third time, and will hopefully continue to provide valuable information on the epidemiology of diabetes and cardiovascular disease in the future.Upsala Journal of Medical Sciences 03/2011; 105(2):135-150. · 1.71 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The hUNC-93B1 gene has the highest expression in the heart. We aimed to explore relationships between the hUNC-93B1 gene and cardiac function, morbidity and mortality in elderly men. Two sub-samples of the population-based ULSAM-cohort (n=330, mean age 71 years and n=152, mean age 75 years, respectively) were used to explore and validate relationships between genotypes of the hUNC-93B1 gene and cardiac phenotypes (ejection fraction, E/A-ratio, left ventricular mass index and relative wall thickness). In the two samples, subjects homozygous for haplotype H3 had 34% and 35% higher level of E/A-ratio compared to non-carriers (p=0.0002 and 0.017, respectively) independent of cardiovascular disease and medication. Using national cause-of-death and hospital-discharge register data with 29 years of follow-up, no heart failure patients homozygous for haplotype H3 were hospitalised for heart failure before the age of 75 years, compared to 25% for heterozygous and 55% for non-carriers (p<0.03). No homozygous subjects died during follow-up while 17% of the heterozygous and 15% of the non-carriers died (p=0.01). Haplotype H3 of the hUNC-93B1 gene seems related to E/A-ratio in elderly men. The relationship between the hUNC-93B1 gene and the age at onset of heart failure and mortality support a view of a clinically relevant impact of the gene.European Journal of Heart Failure 10/2005; 7(6):958-65. · 6.58 Impact Factor - Journal of the American College of Cardiology 03/2003; 41(6):173-173. · 15.34 Impact Factor
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ABSTRACT: In a population-based sample of 475 men the associations between muscle morphology, self-reported physical activity (PA) and insulin resistance (IR) syndrome were investigated. Also, we studied to what degree muscle morphology contributes to the association between PA and IR syndrome. Muscle morphology and the components of IR syndrome were compared in four groups categorized according to self-reported habitual PA data. We found a significantly higher percentage of type I fibres, fibre area and number of capillaries around the fibres and a lower proportion of type IIB fibres with higher level of PA. The relative distribution of type I fibres and capillarization were positively related to high density lipoprotein (HDL) cholesterol and negatively to serum triglycerides (TG) and plasminogen activator inhibitor-1 (PAI-1) activity. The percentage of type IIB fibres was were inversely related to HDL cholesterol and positively to serum TG, PAI-1 activity and resting heart rate. Insulin sensitivity was positively and independently related to PA level (P < 0.001). Regression analysis including all relevant variables regarding insulin sensitivity indicated that the significant explanatory variables left in the equation were body mass index (BMI), glucose intolerance, PAI-1 activity, serum free fatty acid concentration, proportion of type IIB fibres, HDL cholesterol level, drug treatment, PA level, and waist-to-hip ratio, which together explained 55% of the variation in the insulin sensitivity index. In conclusion, both fibre type distribution and muscle capillary density might contribute to the beneficial effect of PA on IR syndrome.Acta Physiologica Scandinavica 08/2002; 175(4):325-32. · 2.55 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to investigate to what degree the capillarization in the skeletal muscle explains the leg blood flow (LBF) changes during hyperinsulinaemia. Fifteen normotensive men from a population-based cohort of 70-year-old men in Uppsala, Sweden, were investigated. Their metabolic status (oral glucose tolerance test and euglycemic, hyperinsulinaemic clamp test results), serum lipid profile, muscle fiber distribution (myosin adenosine triphosphatase staining), and capillary supply (amylase-periodic acid-Schiff method) was evaluated. Doppler ultrasound was used before and after the clamp test to detect insulin-induced changes in LBF. Physiologic hyperinsulinemia (serum insulin, 107 mU/L) caused a moderate increase in LBF (15% +/- 11%; P =.07). Change in LBF was closely related to capillary density (r =.66; P <.01) independent of obesity, smoking and level of physical activity. An association was observed between LBF and serum free fatty acid (FFA) concentrations (r = -.57; P <.05). In multiple regression analysis, capillary density and serum FFA level together explained 71% of the variation in insulin-mediated LBF changes. Capillary rarefaction and elevated serum FFA values were associated with a vasoconstrictive effect of insulin. In conclusion, capillarization in skeletal muscle and serum FFA concentration seem to be determinants of endothelial function.Metabolism 09/2001; 50(9):1078-82. · 3.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: In humans, the Met326Ile missense variant of the p85alpha regulatory subunit of the phosphoinositide 3-kinase (PI3K) has been associated with either significant reductions in glucose effectiveness and intravenous glucose tolerance in Caucasians or a significantly higher insulin secretory response in Pima Indians. In the present study, we genotyped 1,190 Caucasian males to evaluate the impact in vivo of the Met326Ile variant of the p85alpha subunit of PI3K on the acute insulin response, intravenous glucose tolerance, insulin-mediated glucose uptake, and the prevalence of type 2 diabetes after 20 years of follow-up. We also expressed the variant in vitro to evaluate the impact on insulin-stimulated activation of protein kinase B (PKB). The Met326Ile variant of p85alpha was not associated with type 2 diabetes or with alterations in insulin secretion, insulin sensitivity, or intravenous glucose tolerance in vivo. Expressed in vitro, the Ile326 and the Met326 variant acted equally as a dominant-negative and prevented (60-70% inhibition) insulin-mediated activation of PKB by inhibiting the phosphorylation of PKB at Thr308. We conclude that the Met326Ile variant of the p85alpha regulatory subunit of PI3K is likely to be as functionally normal in vivo as in vitro.Diabetes 04/2001; 50(3):690-3. · 8.47 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To measure the effects of hyperinsulinemia on serum electrolyte status and associated hormones, and on serum free fatty acid (FFA) concentrations, in patients with essential hypertension. The serum electrolyte status (Na, K, Ca, ionized Ca, Mg, P, pH) and associated hormones [plasma renin activity (PRA), serum parathyroid hormone (PTH) and aldosterone concentrations], and FFA were measured during an euglycemic hyperinsulinemic clamp test in 49 patients with untreated essential hypertension. Serum potassium, phosphate, PTH, and FFA concentrations decreased during hyperinsulinemia, while serum ionized calcium concentration, pH, and PRA increased significantly (P < 0.05). The changes in serum potassium and magnesium were both inversely related to the insulin-mediated glucose uptake (r= -0.62, P< 0.0001; r= -0.31, P< 0.05, respectively). Both body mass index (BMI) and insulin-mediated glucose disposal were significantly correlated to the changes in serum aldosterone concentration during hyperinsulinemia (r = 0.41, P < 0.01; r = -0.40, P < 0.01, respectively). The change in serum aldosterone during the clamp test was not significantly related to the change in PRA, but tended to correlate to the change in potassium concentration (r= 0.25, P= 0.10). A less pronounced reduction in FFA during induced hyperinsulinemia was associated with low insulin sensitivity (r= -0.35, P< 0.05). Hypertensive patients with normal BMI and a more pronounced glucose uptake showed a larger serum potassium decline and lowered aldosterone concentrations during induced euglycemic hyperinsulinemia. Insulin-resistant patients showed a less pronounced reduction in FFA during hyperinsulinemia. The observations in the present study may indicate that alterations in aldosterone and FFA metabolism might be linked to the insulin resistance metabolic syndrome.Journal of Hypertension 01/2001; 19(1):107-12. · 4.22 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The purpose of this investigation was to examine to what extent variability in the muscle morphology and insulin sensitivity influence the correlation between them. Reproducibility of muscle characteristics was estimated in duplicate biopsies from the same thigh of 23 subjects from a cohort of 70-year-old men. The coefficient of variation (CV) for different characteristics of muscle morphology was between 11 and 42% in duplicate biopsies. Coefficient of variation for markers of insulin sensitivity ranged between 12 and 39%. The variability reflected by intra-class correlation ranged from 0.23 to 0.60 for muscle morphology and from 0.68 to 0.96 for estimates of insulin sensitivity. The correlation analysis between muscle morphology and insulin resistance was performed in a sample of 515 men from the cohort, correlation coefficients were calculated with (rtrue) and without (r) adjustment for intra-individual variation. Insulin sensitivity showed a positive relationship with percentage of type I fibres (rtrue=0.33, r=0.21; P < 0.0001) and capillary density (rtrue=0.43, r=0.21; P < 0. 0001) and negative correlations with percentage of type IIB fibres (rtrue=-0.35, r=-0.24; P < 0.0001). Capillary density was inversely correlated to insulin. Thus, an obvious improvement of the correlation was seen after correcting intra-individual variation. In conclusion, owing to the low degree of reproducibility of muscle morphology variables and insulin sensitivity, implying a noticeable underestimation of correlations, the r-values should be adjusted for within-subject variation in order to demonstrate a more accurate estimate of the strength of the relationships studied.Acta Physiologica Scandinavica 06/2000; 169(2):125-32. · 2.55 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To compare the muscle morphology in hypertensive subjects with that in controls and to test the hypothesis of a relation between heart rate, development of hypertension and muscle morphology that is independent of glucose intolerance. We studied 43 glucose-tolerant, untreated hypertensive subjects and 113 healthy controls in a longitudinal cohort of 70-year-old men. Metabolic status (oral glucose tolerance test and euglycemic, hyperinsulinaemic clamp test), muscle fibre distribution (myosin ATPase staining) and capillary supply (amylase-PAS method) were evaluated. Blood pressure and heart rate data were available from both ages 50 and 70 years. Hypertensive subjects had a significantly smaller mean number of capillaries per fibre than controls (1.53 versus 1.64; P = 0.04). In hypertensive subjects, the proportions of type I and type II fibres were correlated to mean arterial pressure (r = -0.56 and r= 0.52, respectively, P < 0.05 for both). The increase in mean arterial pressure over 20 years was closely correlated to capillary density in mm2 (r= -0.62; P< 0.0001). Capillary supply was inversely related to resting heart rate both at ages 50 and 70 years. Skeletal muscle of glucose tolerant hypertensive subjects showed a lower capillary supply than that of controls. This capillary rarefaction was correlated to increase in mean arterial pressure over two decades and to supine heart rate. This is compatible with the suggestion that higher sympathetic drive might generate structural alterations in muscle capillarization.Journal of Hypertension 05/2000; 18(5):559-65. · 4.22 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The effects on glucose metabolism by the beta-blocker atenolol and the angiotensin-converting enzyme (ACE)-inhibitor trandolapril were investigated in a randomised double-blind parallel group study of patients with primary hypertension. Twenty-six patients were treated with 50-100 mg atenolol and 27 patients with 2-4 mg trandolapril o.d. Intravenous glucose tolerance tests, euglycaemic hyperinsulinaemic clamps and serum lipid measurements were performed after 8 and 48 weeks of active treatment. After 48 weeks insulin sensitivity was reduced by 23% by atenolol while it remained unchanged during trandolapril treatment (+0.5%, P = 0.0010 for difference between treatments, ANCOVA). The effect on triglycerides (+22% vs -8.5%) and high-density lipoprotein cholesterol (-13% vs +0.7%) also differed significantly between atenolol and trandolapril. Results after 8 weeks were similar. Glucose tolerance was not affected by either drug. Atenolol reduced diastolic blood pressure (DBP) better than trandolapril (-15.3 mm Hg vs -6.6 mm Hg for supine DBP after 48 weeks, P = 0.012). The difference in effect on insulin sensitivity between the drugs corresponded to 25% of the baseline values of insulin sensitivity, and persisted over 48 weeks of treatment. The choice of antihypertensive treatment could influence the risk of diabetes associated with treated hypertension. Journal of Human Hypertension (2000) 14, 175-180.Journal of Human Hypertension 04/2000; 14(3):175-80. · 2.69 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A polymorphism (PP1ARE) in the 3'-untranslated region of the gene encoding the glycogen-associated regulatory subunit of type 1 protein phosphatase PPP1R3 is associated with insulin resistance in Pima Indians. The aim of this study was to investigate whether two common variants in the PPP1R3 gene, Asp905Tyr and PP1ARE, are associated with reduced insulin sensitivity or can predict the development of impaired glucose tolerance (IGT) or type 2 diabetes during a 20-year follow-up period in 696 50-year-old Caucasian men. The allelic frequency of Tyr905 was 0.11 (95% CI 0.09-0.13) and of PP1ARE 0.34 (0.31-0.37) and the two polymorphisms were in linkage disequilibrium (chi2 = 46, P < 0.0001, Fisher's exact test). None of the polymorphisms was associated with the development of IGT or type 2 diabetes, but the PP1ARE polymorphism was weakly correlated to whole-body insulin sensitivity (r = -0.08, P = 0.04). In conclusion, we found no evidence in Swedish men that the PP1ARE or the Asp905Tyr variants over a 20-year period predict the development of IGT or type 2 diabetes, but the PP1ARE polymorphism could have a higher penetrance in other populations.Diabetes 02/2000; 49(2):298-301. · 8.47 Impact Factor -
Article: Blood pressure changes in relation to sodium and calcium status in induced hyperinsulinemia.
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ABSTRACT: Insulin increases renal sodium reabsorption which may contribute to hypertension. However, acute insulin administration may result in vasodilation. The aim of the present study was to investigate effects on blood pressure and alterations in ion status during hyperinsulinemia. Blood pressure and serum sodium and ionized calcium concentrations were measured before and at the end of euglycemic hyperinsulinemic clamp tests performed in 45 patients with essential hypertension. Both the systolic and the diastolic blood pressure decreased, by 4% (p < 0.05) and 3% (p < 0.05), respectively. Circulating ionized calcium concentration increased by 2% (p < 0.001), and the ratio between circulating sodium and ionized calcium concentrations decreased. The changes in circulating sodium concentration correlated to changes in systolic blood pressure (SBP; r = 0.36, p = 0.05). Both ionized calcium concentrations and the ratio between circulating sodium and ionized calcium concentrations correlated to changes in SBP during hyperinsulinemia (r = -0.41, p = 0.03, r = 0.56, p < 0.01, respectively). The changes in ion status were not significantly correlated to age, body mass index or insulin sensitivity. In conclusion, a more pronounced increase in circulating ionized calcium concentration and reduction in the ratio between sodium and ionized calcium concentrations was associated with a greater blood pressure decline during the hyperinsulinemic clamp test when performed in hypertensive patients.Blood Pressure 01/2000; 9(2-3):116-20. · 1.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to screen part of the putative promoter sequence in addition to 14 potential phosphotyrosine residues of human IRS-2 for genetic variability which might cause changes in protein expression or function. Furthermore, the potential impact on insulin secretion and sensitivity of a previously identified IRS-2 variant (Gly1057Asp) was analysed. The screenings were carried out by the SSCP-heteroduplex technique on DNA from Type II (non-insulin-dependent) diabetic patients. The impact of the Gly1057Asp variant was analysed in four glucose-tolerant Scandinavian study groups. The results showed no nucleotide substitutions in the promoter sequence, however, a novel heterozygous amino acid variant was identified (Leu647Val). In an association study, the new variant was found in 3 of 413 diabetic patients and in none of 280 glucose tolerant subjects. The variant did not affect the binding of IRS-2 to the insulin receptor or p85alpha of phosphatidylinositol 3-kinase when measured in the yeast two-hybrid system. Examination of the common Gly1057Asp variant in 363 young healthy subjects and in 228 glucose tolerant offspring of one diabetic parent showed no differences in insulin secretion or insulin sensitivity after an intravenous glucose tolerance test. Glucose tolerant middle-aged subjects homozygous for the polymorphism (n = 31), however, had on average a 25 % decrease in fasting serum insulin concentrations (p = 0.009) and 28 % (p = 0.01) and 34 % (p = 0.003) reductions in serum insulin concentrations at 30 and 60 min, respectively, during an OGTT compared with wildtype carriers (n = 107). In a cohort of 639 elderly Swedish men the amino acid variant did not have any detectable impact on insulin secretion after an OGTT. No genetic variability was found in the IRS-2 promoter. A rare IRS-2 variant at codon 647 has been identified in Type II diabetic patients. The prevalent codon 1057 polymorphism had no consistent effect on insulin secretion or insulin sensitivity. [Diabetologia (1999) 42: 1244-1249]Diabetologia 11/1999; 42(10):1244-9. · 6.88 Impact Factor - Journal of Human Hypertension 05/1999; 13(4):285-6. · 2.69 Impact Factor
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ABSTRACT: In order to study if the vasodilatory action of insulin is impaired in essential hypertension, 24 untreated patients were challenged with a 2 h euglycaemic hyperinsulinaemic clamp (56 E/m2). Cardiac index (CI) was measured by thoracic impedance cardiography and leg blood flow (LBF) by Doppler ultrasound. During the clamp procedure a significant decline in blood pressure was seen (3.0-5.6% over 120 min, P < 0.001). However, no significant effects on ejection fraction (+6 +/- 8 s.d.%), CI (-1 +/- 2%), heart rate (+2 +/- 1%) or total peripheral resistance (TPRI, -0.5 +/- 2%) were found. LBF increased by 22 +/- 35% (P < 0.005). These haemodynamic effects of insulin were not related to age, sex, body mass index, blood pressure or the insulin-mediated glucose uptake during the clamp. In conclusion, insulin increased LBF, but no changes in CI and TPRI were seen in the hypertensive patients. Furthermore, no association between the ability of insulin to induce vasodilatation and to promote glucose uptake was seen.Journal of Human Hypertension 02/1999; 13(1):41-5. · 2.69 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to investigate the relationships between angiotensin-converting enzyme (ACE) activity in serum and skeletal muscle to blood pressure and the long-term antihypertensive effects of fosinopril and atenolol. We examined 50 hypertensive patients randomized to receive 20 mg fosinopril or 50 mg atenolol daily for 16 weeks. ACE activity was measured in biopsy specimens from skeletal muscle. Measurements of office and ambulatory blood pressure, serum ACE, and left ventricular wall thickness were also performed. The same investigations were performed in a cross-sectional study of 50 healthy elderly men. Muscle ACE correlated inversely to blood pressure in cross-sectional analyses in both populations (p < 0.05). During atenolol treatment muscle ACE activity tended to increase (14%, p = 0.059), and this increase correlated inversely to the changes in standing systolic and diastolic blood pressure (r = -0.62, p = 0.0044, and r = 0.54, p = 0.016, respectively). Muscle ACE was also inversely correlated to left ventricular wall thickness when the two populations were pooled (r =-0.29, p = 0.0053). In the fosinopril group, muscle ACE activity was not different during treatment than at baseline (-2. 1%, p = 0.68). The inverse relationship between blood pressure and muscle ACE levels in this study indicate that muscle tissue ACE levels are influenced by haemodynamic factors in humans.Blood Pressure 01/1999; 8(1):16-22. · 1.61 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Human obesity is associated with an increased tumor necrosis factor-alpha (TNF-alpha) mRNA expression in adipose tissue. TNF-alpha decreases insulin-dependent glucose uptake by inhibiting autophosphorylation of the insulin receptor, suggesting that TNF-alpha may play a role in insulin resistance. In this study, we analyzed plasma levels of TNF-alpha in 40 70-year-old men with newly detected non-insulin-dependent diabetes mellitus and in 20 age-matched controls. Twenty of the patients had a moderate level of insulin resistance and 20 were severely insulin resistant. The plasma levels of TNF-alpha were higher in patients (4.00+/-1.53 pg/mL in moderately insulin resistant and 4.91+/-1.43 pg/mL in severely insulin resistant subjects) than in controls (3.27+/-0.79 pg/mL, P<0.001). TNF-alpha was significantly related to body mass index, fasting glucose levels, and serum triglyceride levels and inversely related to the high density lipoprotein cholesterol level. The finding of an association between high plasma levels of TNF-alpha and several metabolic abnormalities characteristic for the insulin resistance syndrome suggests that TNF-alpha may be involved in the pathogenesis of non-insulin-dependent diabetes mellitus.Arteriosclerosis Thrombosis and Vascular Biology 08/1998; 18(8):1199-202. · 5.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: A high plasma renin activity (PRA) has previously been related to several cardiovascular risk factors as well as to later cardiovascular events. As insulin resistance has been suggested as the unifying factor in the insulin resistance metabolic syndrome, insulin resistance was evaluated by the euglycaemic hyperinsulinaemic clamp technique in 50 untreated hypertensive subjects in whom PRA and serum aldosterone were measured together with lipids and an intravenous glucose tolerance test (IVGTT). PRA was inversely related to insulin-mediated glucose disposal during the clamp (r=-0.31, P < 0.05), as well as to fasting insulin (r=0.32, P < 0.05) and to insulin at 60 min at the IVGTT (r=0.30, P < 0.05), but not to other risk factors. Serum aldosterone was not related to any of the metabolic risk factors. In conclusion, the present investigation showed that insulin resistance is associated with elevated levels of PRA in patients with untreated essential hypertension. It thus seems as if a high activity in the renin system should be included in the disturbances included in the insulin resistance metabolic syndrome, a syndrome with a major impact on future cardiovascular events.Journal of Human Hypertension 06/1998; 12(6):379-82. · 2.69 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Left ventricular hypertrophy (LVH) has been associated with insulin resistance, a condition with an impaired insulin-mediated vasodilation in skeletal muscle. ACE-inhibitors have been reported to be superior to most other antihypertensive drugs in inducing a regression of LVH. In a double-blind study with parallel groups, 50 patients with essential hypertension were randomized to treatment with either fosinopril (20 mg o.d.) or atenolol (50 mg o.d.) for 12-16 weeks. Left ventricle wall thickness (LVWT, defined as the sum of interventricular septum and posterior wall), diastolic function (represented by the ratio between the E-wave and the A-wave of mitral blood flow) and femoral artery blood flow (FBF) were evaluated using ultrasonic measurements. FBF was measured at normoinsulinemia and after 2 h of euglycemic hyperinsulinemia. Before treatment, the insulin-induced increase in FBF was inversely related to the LVWT (r = -0.52, p < 0.02). The reduction in ambulatory 24-h SBP/DBP was 13/9 mmHg for fosinopril and 15/14 for atenolol, ambulatory DBP being significantly more reduced by atenolol (p = 0.03 for difference in treatment effect). However, only fosinopril treatment resulted in a significant reduction in LVWT (from 20.5 mm to 19.4 mm, p < 0.05). The degree of reduction in LVWT was related to the increase in FBF in the fosinopril group (r = -0.45, p < 0.05). For fosinopril (but not for atenolol), there was a positive relationship between the change in E/A ratio and the change in femoral artery stroke volume (r = 0.80, p < 0.01). Conclusion: Impaired insulin-induced stimulation of leg blood flow was related to an increased LVWT. Furthermore, during fosinopril treatment, regression of LVWT was associated with enhanced skeletal muscle blood flow during hyperinsulinemia. This indicates that impaired peripheral blood flow (and thereby increased afterload) may be a possible mechanism explaining the previously found association between insulin resistance and cardiovascular hypertrophy.Blood Pressure 05/1998; 7(2):118-26. · 1.61 Impact Factor
Publication Stats
603 | Citations | |
123.19 | Total Impact Points | |
Top Journals
Uppsala University
- Department of Public Health and Caring Sciences
Uppsala, Uppsala, Sweden
Steno Diabetes Center
Gjentofte, Capital Region, Denmark
Uppsala University Hospital
- • Department of Internal Medicine
- • Department of Geriatrics
Uppsala, Uppsala, Sweden -
Karolinska Institutet
- Institutionen för medicin, Huddinge
Solna, Stockholm, Sweden


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Hilltop Apartments
5601 Viewpointe Drive, Cincinnati, OH 4521301/12/15 by anonymous:
I have referred many to Hilltop when looking for an apartment in the Kennedy Heights area. It is secluded, yet still provides accessibility to many local businesses. The community as a whole is well maintained. Those are a few things that draw you to Hilltop, but the staff is what gets you to stay. They are always friendly and courteous. Ms. Etta goes above and beyond for the residents; providing more
Harper's Point
8713 Harperpoint Dr., Cincinnati, OH 4524912/30/14 by anonymous:
I like living here but am really worried about my upcoming rent increase - I've watched a lot more people than usual moving out over the last couple of months and not many folks moving in - has me expecting a big rent hike...was hoping to stay here for awhile but won't be possible if the increase is big. The apartments are clean and though older I think they are well kept. To date more
Estates at Fernview
2587 Fernview Court, Cincinnati, OH 4521201/20/15 by adak360:
No complains for The Estates at Fernview! The area is quiet and peaceful, for the price of the apartments you can't go wrong. Cindy, the property manager, tries her best to keep tenants happy with their stay. more
The Gramercy on Garfield
135 Garfield Place, Cincinnati, OH 4520209/02/14 by Verified Resident:
The location is wonderful. Easy access to downtown, the banks and OTR, so you are connected to multiple places. The building is nice and the size of a one bedroom is perfect for urban living. The pool and parking are also great to have in the same building. more
Centennial Station
4209 Erie Avenue, Cincinnati, OH 4522701/19/15 by Verified Resident:
Excellent service! I live in a pleasant location for my lifestyle and the Centennial Station makes that possible! All service requests were completed within 24 hours and all my encounters with the staff has been positive! Plus I enjoy their workout facility! more
Galbraith Pointe Apartments
8240 Galbraith Pointe Lane, Cincinnati, OH 4523112/05/14 by Dornetta Arnold:
I been here for 4year me and my son love it here it is home for us its a nice and clean community as long as Galbraith Pointe have me and my son this will be our home we are very happy here IM very happy for Decnisa Chaney she a wonderful manager we really care about the people here and make sure everyone is happy and the up keep of the apartment. more
Lofts at Shillito Place
151 West 7th Street, Cincinnati, OH 4520209/02/14 by Verified Resident:
A wonderfully situated, spacious, apartment complex right downtown with caring staff, well-maintained facilities, beautiful pool. There are incredibly fast responses to our very few maintenance requests and they were resolved completely. I love being able to quickly walk to Fountain Square, OTR, and the Banks/Riverfront area. more
Groton Lofts
704 Race Street, Cincinnati, OH 4520209/02/14 by Verified Resident:
I am very happy with my loft style apartment located downtown Cincinnati. Great location. I can walk to many restaurants and event. I have beautiful big windows! It also has a nice balance of hard wood floors and carpet. In apartment washer & dryer and a balcony would make this place absolutely prefect! more
Mt. Adams Living
1055 Saint Paul Place, Cincinnati, OH 4520209/02/14 by Verified Resident:
Mt Adams is a wonderful community to live in. The community is vibrant and active 365 days a year. While living in Mt. Adams you will have the opportunity to meet many of the great people of Cincinnati. I would definately recommend renting from Towne Property if given the chance. more
Olde Towne in Kenwood
6915 Lynnfield Court, Cincinnati, OH 4524309/02/14 by Verified Resident:
It has been a good experience overall. Just wish we had a washer and dryer hook up in this townehome. Sometimes the pool is a bit cold even on really warm days but has been better in the last couple years. Otherwise has been a good area to live and the rent is reasonable. more
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Learn from the Olympics
Blog Entry:
August 13, 2012 4:30 AM | Author: LAURA SHERIDAN
Laura Sheridan
Laura Sheridan is a brand strategist who leads
Viva La Brand
, the strategy firm focused on optimizing your brand to drive profitable growth.
The Olympics were a big winner for NBC and its viewers, and there's a lot to learn from the network's success. A sample of 50 random people provided these reasons for loving the ultimate contest between athletes.
Reason No. 1: They were fresh.
Nielsen reports a decline in overall TV viewing. Viewers are bored with reality TV, spinoffs of dramas, and 24-hour news shows, and are shifting their attention to the Internet.
Enter the Olympics. Viewership records were broken: 40 million Americans tuned in to watch the opening ceremony alone. Why the interest? They're different and they're relevant. Whether you ran track in high school and could relate to what it takes to train for the 400-meter dash, or you connected with gymnast Aly Raisman's parents -- who were caught on YouTube doing their own routine -- the event was full of surprises. And, marketers take note, Americans like relevant, fresh surprises.
Reason No. 2: They were easy.
Berets off to the broadcasters who provided just the right amount of information as they explained the events. Unlike the commentary during other sports events like the Tour de France, which erroneously assumes viewers understand the various stages and classifications, NBC shared tidbits about the scoring and athletes' personal lives that were dumbed-down so we could multi-task while watching and still feel a part of it.
Reason No. 3: They were focused.
Face it: Gold medal winners got there by identifying a niche and devoting virtually every hour of every day for many, many years to achieve greatness. There's a reason why you didn't hear about gold medal winners who had picked up the sport last year after dabbling in three others before that. Lacking focus doesn't result in success. Scattershot attempts waste time and money.
So, what can we marketers learn for the Olympics?
Be fresh. Give something new to prospects and customers.
Make it easy. You understand your products and web site, but can a newcomer?
Stay focused. Don't deviate from your core skill.
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My husband and I knew a Cornelius Laird in Louisiana who graduated from high school in 1957. He was very musically talented. The last time my husband saw him was in 1970. He was living in an apartment in Texas with several other people. His behavior and appearance, according to my husband, was probably what could be described as "eccentric". We lost track of him after that. He had a sister named Opal who graduated in 1955, I think. I was thinking about him this evening and searched the internet where I found your message which is several years old. Let me know if you found Cornelius. Notify Administrator about this message?
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Ethel is my grandmother, married William John Plog, my grandfather. They had 5 daughters and one son, who was my father. I am in contact with La Visa Cate's daughter, my cousin. Please let me know what information you need. Notify Administrator about this message?
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im a teenager and i really love to bake.i'd like to make some cute cupcakes and sell them at local craft shows or maybe have it where people can order them for parties or something.can i do this without a license or certificate from the health dept. or do i need one?thanks in advance!!
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We had a fantastic birthday dinner here tonight. I had grilled tuna and John had black & blue sirloin steak. The vegetables were perfect, as was the meat. We loved sharing the peanut butter pie served for dessert. What a treat!!
We had a fantastic birthday dinner here tonight. I had grilled tuna and John had black & blue sirloin steak. The vegetables were perfect, as was the meat. We loved sharing the peanut butter pie served for dessert. What a treat!!
Fresh fruit juices, homecooked bread, salad, my family loved the burger steak and sausages served at breakfast
We cannot say enough about the Benn Conger Inn. My husband's class from Groton, NY celebrated their 60th class reunion there on August 1, 2014. Peter and Doug are outstanding Innkeepers. The atmosphere is charming and the food was delicious. There were several waitresses and they are some of the best we have seen anywhere. We stayed at the Inn... More
We first went to tour the 1890 House in Cortland which was a very nice hour tour. My husband had made reservations at the Benn Conger Inn and restaurant for 5:00 p.m., and we were seated right away. We were greeted by the owners who were very pleasant to us. This is a very beautiful place, and the food was... More
As a small child, I grew up in Locke, NY. In 1986 our wedding reception was held at the Benn Conger. This August I was invited to the Moravia Central School class of 1974 40th class reunion in the area. I have many memories of Groton, Locke, and Moravia and of the Benn Conger. It was a pleasant surprise to... More
On Aug. 1, 2014, I dined at the restaurant for a 60th High School Reunion. Great atmosphere, food and service. Would highly recommend it. It is a Bed and Breakfast. I didn't stay there, but the classmates who did said really nice things about their stay. Dick Metzgar Clayton, GA The selections on first time visit do not go back... More
From the moment you arrive till you leave Peter and Doug and their staff make you feel welcome. Rooms are lovely and food wonderful. A very comfortable and relaxing place to stay in the finger lakes area of ny
We had a wonderful dining experience. The service was superb, the food excellent. And joining Peter for an after dinner drink in the cozy bar was a treat. We don't get to the Benn Conger as often as we would like, but every time we go, we wonder why we waited so long to return. You won't be disappointed!
This is probably the 4th or 5th time I have enjoyed a great meal at the BGI. The environment, the host (either Peter or Doug), the quality of the food and the wait staff always give you a outstanding time and for true value. If you are looking for delicious food, intimate and detailed dining experience this is definitely the... More
Visiting with family took us to this restaurant where we were treated like family and there was no need to ask for seconds! The prime rib, duck and veal oscar were out of this world and the accompaniments surprising! There were veggie towers that you couldn't stop eating, delicious sweet potato and zucchini fries and the coolest salad presentation I... More
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SunPower Corporation ( SPWR ) announced that it has invested in Diamond Energy Pty Ltd (Diamond Energy), a privately-owned, alternative energy project developer and clean electricity retailer headquartered in Melbourne, Australia. SunPower has acquired a minority stake of approximately 42% in Diamond Energy and under terms of the agreement has an option to increase its ownership percentage over time. SunPower will also assume a seat on the company's board of directors. Aligning with Diamond Energy will allow SunPower to offer more comprehensive and customizable clean energy solutions for customers in Australia. The unique partnership creates a one-stop shop for consumers, providing high efficiency solar electric systems, grid-source renewable energy, and retail services such as metering, billing, and management of exported electricity to the grid. Established in 2004, Diamond Energy specializes in developing, delivering and managing renewable generation, cogeneration and interruptible load projects with a breadth of experience spanning solar, bioenergy, wind and wave technologies. The company currently owns two biogas plants, has power purchase agreements with a number of third-party generators and as Australia's "Solar Friendly Retailer" sells clean energy through its retail divisions to its residential and Commercial Green customers. Diamond Energy holds licenses to deliver electricity across the National Electricity Market ("NEM") in Australia. SunPower and Diamond Energy will also work for the development of commercial and utility solar power projects in Australia, leveraging SunPower's experience, delivering more than 1,000 megawatts of cost-competitive, large-scale solar power systems worldwide. With a presence in the country since 2008, SunPower has deployed the utility-scale Uterne solar power plant in Alice Springs and delivered commercial-scale solar power systems for customers such as Crowne Plaza Hotel, Perth Zoo, Central Institute of Technology and Midland Redevelopment Authority. SunPower is a vertically integrated solar company with presence across the entire solar value chain. The company designs, develops, manufactures, markets and sells high-performance solar electric power technology products, systems and services worldwide for residential, commercial and utility-scale power plant customers. The company's semiconductor-based solar cells and solar panels, which convert sunlight into electricity, are manufactured using proprietary processes and technologies. SunPower is largely owned by French oil major Total S.A. ( TOT ). SunPower is witnessing falling ASPs and margins in its residential and small commercial markets segment which accounts for approximately two-thirds of its topline. We expect the trend to continue unabated in the near future with valuation further restrained by the higher cost structure of the company compared to its peers besides subsidy roll-back risk in Europe and foreign exchange risk. SunPower presently retains a short-term Zacks #3 Rank (Hold) that corresponds with our long-term Neutral recommendation on the stock. SunPower mainly competes with Suntech Power Holdings Co. Ltd. ( STP ) and First Solar, Inc. ( FSLR ).
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F o r t y User ID: 453267 United States 10/14/2008 01:14 AM Report Abusive Post Report Copyright Violation | Friendly enough for you to coincidentally greet me on the boards when I awake in the morning. Personal friendly banter? I knew a kid who tried to commit suicide by jumping in front of a train, years ago. He lived. Some believe, you can't make it shorter or longer, no matter how much research you do. Quoting: the professional 437387[link to www.youtube.com] "You're nothing but a pack of cards." - Alice in Wonderland ahhh come now, do you really believe I know when you wake up in the morning? I'm up all night, so I monitor all these various boards...when someone else posts, I post. Or rather, when i realize someone else has posted, I post. I like to see myself talk maybe *shrugs*...but i certainly haven't the slightest clue who you are or what time you wake up. If I indeed posted "to you" just before or after you woke up and got on this board (or whatever you are referring to) it is merely a co-incidence...if such things truly exist...im not so sure they truly do, perhaps all things are connected. But I am certainly a friend and have no malicious feelings towards anyone here, there, or anywhere...unless of course they express malicious feelings towards me first I suppose. Take that however you must....but I am not malicious in any case....just an observer, and sympathetic let's say. The meek inheirit the earth perhaps, and then they aren't so meek anymore. |
fortwynt User ID: 453267 United States 10/14/2008 01:58 AM Report Abusive Post Report Copyright Violation | An important, though little known chapter in Scorpio lore is the placement of the Eagle in polarity to the Scorpion. Most Scorpios, if they dare be so revealing, would confess of an ongoing internal conflict between two distinct aspects of their nature. For individuals with a strong Scorpio influence, this may feel sometimes as a civil war of the self. |
Triggers Scared Me? AAIIEEE User ID: 437387 Canada 10/14/2008 09:23 AM Report Abusive Post Report Copyright Violation | Will Diamond Girl ever find love? Thread: Let's Get Serious: I Think It's Time To Talk SNIPER RIFLES. (Page 2) Quoting: marcusmaximusAnd oh yeah, free speech only works if you use it. Don't be afraid, or you've already lost. __________________________________________ Well said, I can't believe people are living in a place where they feel they need to censor themselves, yet they aren't having the same thoughts as you... It only gets worse folks. The result is the same in the end, your silence is only buying you time, and damning your children to slavery and oppression. If the deer population is allowed to run free with no checks and balances mankind will one day exists only to serve a few privileged deer. ______ This is why it's EXTRAORDINARILY important to teach the value (and public service!) of hunting to children. [link to www.liveleak.com] Look - two runaway MC deers try to escape Markusmaximus' hunting party. In a Shakespearean demonstration of dramatic irony, Lady wHenchpeck doth protest "Out, out foul nut", too loudly. Though apparently debilitated by a repetitive ritual, appearances are deceiving. Therapists counsel: 'Homicidal tendency is evidence suicidal impulse is decreasing immensely.' [link to www.youtube.com] Tiger: Their love relationship with dog and horse works out well and does not work well with monkey. Ox is the wedding star for these people and they are likely to find their soul mate in the year of ox. Keeping a stone or porcelain model of an ox in the northeast section of their house or carrying an ox key chain helps them in finding the right person. [link to www.targetwoman.com] |
Fort Scorpius User ID: 526332 United States 10/14/2008 07:24 PM Report Abusive Post Report Copyright Violation | Tiger people are difficult to resist, for they are magnetic characters and their natural air of authority confers a certain prestige on them. They are tempestuous yet calm, warm-hearted yet fearsome, courageous in the face of danger yet yielding, soft and mysterious. They enjoy a life full of challenges and unexpected events, like visiting unusual places and meeting interesting or outstanding people. Other people in their area are easily attracted by the tiger's enthusiasm and way of life. Tigers find pleasure in the unpredictable, and while other people would rather make a backward step, they are not afraid to explore the new and unusual. But it is not that simple to interest the Tiger. |
Fort User ID: 526332 United States 10/14/2008 07:29 PM Report Abusive Post Report Copyright Violation | The Indian Goddess Druga often rides a tiger. The tiger skin is worn by Siva in his destructive aspect. In Greek are the tiger is sometimes substituted for the leopard in depictions of the God Dionysus. The tiger is of great importance in the Chinese myth and symbolism; he takes the place of the lion in this yang aspect, as courage, prowess, authority, military might and ferocity. Tigers are also considered Lord of the land animals in China. In Japan, the tiger, although mythical is credited with an age of 1000 years and used to symbolize courage and the qualities of war heroes. Tiger indications are: to take action, no questions asked just do it. Unpleasant but necessary action only gets worse with procrastination. Find strength and will power to tackle an unpleasant task. |
Que User ID: 510209 United States 10/14/2008 07:41 PM Report Abusive Post Report Copyright Violation | |
wood water tigers User ID: 437387 Canada 10/15/2008 01:34 AM Report Abusive Post Report Copyright Violation | A tiger has grown wings and is relieved of the dogpile. [link to www.youtube.com] To a disintegrating Manchurian, the richest man in Babylon is poor. |
Frankie User ID: 437387 Canada 10/15/2008 01:37 AM Report Abusive Post Report Copyright Violation | A tiger has grown wings and is relieved of the dogpile. Quoting: wood water tigers 437387[link to www.youtube.com] To a disintegrating Manchurian, the richest man in Babylon is poor. "To interest a tiger." The mass media is an area of social control, they have been working on for fifty years or more. Project Mockingbird's codex of books and literature morphed easily into a need for hegemony on the internet. If a person has developed psychological disabilities as a result of being tortured in childhood, StrugholdStraggler's exploitation of heavy trauma loads in pursuit of expanding the shock doctrine's administration and cracking cosmic eggs will find them opportunisitc. Opportunistic, like bacteria's aggregate like. An experiment in compelling people to suicide in an mass media mind control model, that favors attacking people with psychological vulnerabilities? Thread: A STRONG WARNING TO VICTIMS OF MIND CONTROL--SRA/MPD/DID (Page 6) 'I think its funny that some people are talking about actual 4 legged antlered animals and others are talking about a different deer..... Thread: Let's Get Serious: I Think It's Time To Talk SNIPER RIFLES. (Page 7) Yeah...Aristocratic deer are best." - Markus Maximus Cybersniper the "she doesn't look disabled" invisibly disabled? "MPD, how do you know?" Atlantean Aristocrazy Maria? "The Internet is a weapon" in Stanford Streamlined Dogpiling. "Cabin pentagon psychic" project paperclip death whizzing. What if they aren't looking for fascist Islamists who suit a new world order, but want to demoralize your children. [link to www.youtube.com] Right under your nose - "In plain sight" wHitley's place of admiration for hiding deceptions - the Kamps oven's are firing up your very own children with cracked cosmic egg pedantry. Witness wHitlery's acute curiosity to understand how best to manipulate subliminally with verbal and written cues, triggers and traumatized shock doctrines. The Rumor Mongers Are Out In Force Again Saturday September 5th, 1998 [link to www.unknowncountry.com] "The UFO community has attracted many marginal individuals, poorly educated and credulous people, people with mental problems, the paranoid and the congenitally vicious. That was true ten years ago and thirty years ago, and it is true now. The Internet has amplified these voices, but it has not changed the fact that they are as wrong and as wrong- headed as ever." "Spectacularly crazy Rickie Mcfee" hasn't threatened to skin, mutilate, fritter or shoot anyone?!?! [link to www.theblackvault.com] Tales of My Author Tour: Speaking at the Pentagon Bookstore Thursday December 31st, 1998 [link to www.unknowncountry.com] "At the back of the small crowd, three more uniformed Air Force personnel stood alternately listening and chatting among themselves. I could not tell their mood. But the two directly in front of me never softened their expressions in any way. In fact, they looked almost paralyzed with hate. In my memory of six author tours on the UFO subject, I do not recall seeing such expressions on any other faces. To my eye, they were not sane expressions. Frankly, they were frightening." Pat Roberston has agreed with OSR! Pat Robertson Threat Early 1998 [link to www.unknowncountry.com] His "degenerate culture laughed it off with" tortures' mainstay: Sexual degradation. A Huge Question Answered Thursday October 16th, 2003 "..our degenerate culture was laughing it off with rectal probe jokes. " [link to www.unknowncountry.com] Would the compromised adult psyche maturation that occurs in early childhood trauma constitute: "Big Babyness." Big Babies--UPDATE Thursday May 18th, 2006 [link to www.unknowncountry.com] "...these so- called "researchers" are, for the most part, a bunch of big babies." "..would rather scrabble in the sandbox." - Waffle following dogpiling? Fight for psychological survival, or stand up to prescient deceptive PP trickle down death whizzing? "Critical Mass". The critical mass of the path of least resistance, which is the one, monkeys most enjoy, is staved off by incarnating a few 'light beings' from Master Balrog Brink's Krystal city. Should secrecy's relativity ever reach critical exploitability - they'd farm you all. Do you suppose there is a shared interest? Project Paperclip trojan psy ops and advertisers? "I realized, after years of hearing the church bells at the same time every day, that they werent bells at all, but recordings of bells. Randall Flagg says sit on the floor, as chairs are for liars. I am the trashcan man. Let's wait and see if the 14th brings the do-gooder aliens to save us from ourselves."- Fortwynt/lady wHenchpeck? "Is there really such a thing as coincidence?" Who are You? [link to www.unknowncountry.com] "Is there really such a thing as coincidence?" Subliminal threat is more effective than direct sniper parties, at triggering hyper vigilant trauma loads in the shock zone. Subliminal Sex [link to www.unknowncountry.com] "Researchers have discovered that we can be influenced by sexy ads on TV, even when they are subliminal—in other words, they flash by too fast for us to be consciously aware of them. " Sneaky Subliminal Advertising—Why it Works [link to www.unknowncountry.com] "Thirsty people can be made to drink more than they normally would by being exposed to subliminal facial expressions, which are not seen consciously. " Subliminal Message Found to Work [link to www.unknowncountry.com] "The study proves that subconscious learning may affect our conscious decisions without our knowing it. Says Merikle, "It's what advertisers have known all along: if we just keep the exposure rate up, people will be influenced." " How to Use Your Brain Better [link to www.unknowncountry.com] "..Human memory relies mostly on association; when we try to retrieve information... Neurobiologists are trying to get a better idea of how associative memory works. " Sounds like dramatizing heavy trauma loads: Association. What Do You REALLY See? [link to www.unknowncountry.com] "Subliminal messages ARE registered by our brains—despite the fact that we don't consciously see them. Alfred Hitchcock wove frames of the subliminal image of a skull-and-crossbones into his films in order to increase the tension for viewers. " TV Ads for Meds May Make Us Sick [link to www.unknowncountry.com] "Studies have shown that patients who go to their doctors and ask for a medicine they saw in an advertisement are likely to get it.." An interest for Project Paperclip's Inquisitor cum Pontius Pontifex of Las Vegas? The Power of Words [link to www.unknowncountry.com] "But new research suggests they may play a far greater role than simply replacing a proper name in a sentence—they help keep our brain from being overloaded." Speaking in Tongues [link to www.unknowncountry.com] "Now scientists are attempting to explain what actually happens to the brain of someone when this happens. Researchers at the University of Pennsylvania School of Medicine have discovered decreased activity in the frontal lobes, an area of the brain associated with self control." An army of psychologists paid to determine how best to manipulate your mind with a total awareness surveillance network, prescient in its dogpiling deceptions of relative secrecy. Recognizing the best targets for experimenting on with the Mass Media Mind Control Magic "Triggers? AAAIIEEE? Me Scared?!?!" Bullet. Personality Problems: Blame Your Cat [link to www.unknowncountry.com] "Women who are infected have what we have come to think of as typical female personalities: warm, outgoing and attentive to others. Infected men are less intelligent and somewhat boring—the typical image of the guy sitting in front of the TV with a beer. Both infected men and women feel more guilty and insecure." "Memory works mainly by association" - Like negotiating heavy trauma loads with dramatization. When Your Brain is at War [link to www.unknowncountry.com] "Carey writes: "Memory works mainly by association." Sarcasm—What is It? [link to www.unknowncountry.com] "Patients with prefrontal brain damage had trouble comprehending sarcasm, while the people in the other two groups had no such problems. People with damage in one specific part of the brain had the most trouble with comprehension. " Gamblers have the same psychotic brain dysfunction as internet addicts, suffering the highest suicide rates of all the addcitive patterns: no substance involved in the psychotic thinking, makes it harder to break the cycle of delusion. Gamblers May Have Brain Damage [link to www.unknowncountry.com] "Gamblers who lose more money than they can afford and who can't stay away from the slot machines may have a form of brain damage." Hypnosis Found To Alter Brain Activity [link to www.unknowncountry.com] "It seems clear that what hypnosis does is to increase suggestibility.." Lady wHenchpecks who doth caretake with zealotry, repetitively doth protesting too loudly "Out, out foul nut" can learn about "blurry shock moments" hypnotists exploit taking courses. Movie Psychology [link to www.unknowncountry.com] "Neuroscientist Uri Hasson started out by showing dramatic movies, such as Hitchcock films, to people and while watching to their brains with an fMRI machine, to see what parts of the brain "lit up" during which parts of the film. The Hitchcock film caused similar responses in the same area of all the viewers' brains" The Gov. is Trying to Read Your Mind [link to www.unknowncountry.com] "There may also be the problem of the enemy "thinking" lies, which could be even easier than trying to fool a conventional lie detector. " Like pornography, always a market for Horror. The most logical vehicle with which Project Paperclip scientists and advertisers would experiment a shared an interest in compelling with fear. Why is it Fun to be Scared? [link to www.unknowncountry.com] Psychologist David Zald says, " If something is safe, you don't have to pay attention to it." It's fun to have your "cosmic egg cracked" in pursuit of corporafasci Flagg freedom. Project Paperclip's Death whizzing projections, look more Freudian than psychic. "A legion of nuts" and those are the ones who haven't been presciently dogpiled with deceptions following skinned mutilation. You won't be brainwashed once they shoot you. |
Frankie User ID: 437387 Canada 10/15/2008 01:38 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 385176 United States 10/15/2008 01:40 AM Report Abusive Post Report Copyright Violation | Watch out for the MK Ultra Big Pharma Initiative doctors, coming to a Milton Friedman Gitmo on the catastrophic go go, near you. Quoting: specks on a cold river 437387"..fairly punctual, when she keeps appointments." Only fairly? "Condescending" "..forbids email.." Reminds me of Harlow's hard wire rack already. "Always tries to prescribe me a new drug" MK Ultra New Freedom Big Pharma Initiatives to continue on with Dr Cameron's work? [link to www.ratemds.com] Psychiatric INDUSTRY is split down the middle on the ethics of torture. Half of them are choosing to get Rich, Rich, Rich, by torturing people and some people are getting mutilated and locked away. "we must try to identify these people BEFORE they act and lock them away" [link to www.unknowncountry.com] There's a guy starting to realize that eternal fate has turned its back on him. Please surround yourself with trustworthy friends and or Christians (which are able to shield from the demonic onslaught soon to occur) St Michael perfects things, and perfect is enemy of the Good. What does Milton Freidman have to do with any of this? Linking to Anne Strieber, lol? She's as bad as Whitely and certainly reinforces his paranoia. |
Frankie User ID: 437387 Canada 10/15/2008 01:49 AM Report Abusive Post Report Copyright Violation | What does Milton Freidman have to do with any of this? Quoting: Anonymous Coward 385176Linking to Anne Strieber, lol? She's as bad as Whitely and certainly reinforces his paranoia. 'Lock him up before he hurts anyone.' [link to www.youtube.com] Got an autographed book, suckers. |
Anonymous Coward User ID: 385176 United States 10/15/2008 02:10 AM Report Abusive Post Report Copyright Violation | Do you all speak your own language or what! Quoting: Anonymous Coward 514144Explain it to the regular folk. AC, they are victims of mind control, attempting to communicate what they know, without triggering some kind of punishment programming. IOW, they aren't supposed to to talk. The ones that can communicate in a direct fashion are few and far between. One of the several reasons they were selected (a more mundane one) is their high intelligence. Unfortunately, that works against them, as they have demonstrated. What they are is Mancurian candidates. They were totured by gov't/private contractors/head shrinkers/acedemia and occultists (all rolled into one!) to be "perfect tools", or slaves of the evil ones running the planet. They are spies, drug mules, prostitues, sex slaves, courriers, assassins, etc., who are used by the people/entites who tortured and programmed them. They have multiple personality disorder/dissociative identity disorder, and each of the personalities or "alters" has different funtions. One alter can go out and commit an act, or perform a job, and the main person (host) is unaware (usually). Some remember and try to tell. The deal is they can be "switched on" or "triggered" by a word, a poem, a signal, ect., and they are off to do their programmed function. One of the thoughts is that the so called "alien abductees", who all seem to think they have some unknown mission that will suddenly become clear to them, will be triggered and go apeshit, causing havoc on behalf of the Satanic New World Order (their programmers and handlers). Many of them are the self described new age "ligtworkers" and Obamatards, lol. The others are fundies (fake Christians) who support the ZioNazis. /hth |
Anonymous Coward User ID: 385176 United States 10/15/2008 02:16 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 385176 United States 10/15/2008 02:19 AM Report Abusive Post Report Copyright Violation | |
Frankie User ID: 437387 Canada 10/15/2008 02:33 AM Report Abusive Post Report Copyright Violation | There's a special place in hell for these handlers. Quoting: Anonymous Coward 385176___ yes there is and Unknown Country is crawling with them Controlling and handling comes naturally to all Ralph Klein's trickle down date rape cocktail charity peasants wounded by the Atlantean Aristocratic war on God. PP death whizzers capitalize on the waiting hunting parties for their beta sex slave girls. Tracy got invited out for a drive! The attraction of suicide for these women may be a way to gain power over their own fates." [link to www.psychologytoday.com] Earth Prisoner of War dilemmas. Abdicate fate - to Frankenstein's resurrection. [link to www.youtube.com] |
Anonymous Coward User ID: 385176 United States 10/15/2008 02:40 AM Report Abusive Post Report Copyright Violation | Sicilians don't like thieves, especially the ones who mutilate the crippled widowed orphans they steal from and then call their six year olds crazy for being suicidal, when they'd be crazy not to be. Quoting: Triggers scared AAIIEE me? 437387"A hostage situation" quipped the prescient Cassandra. Of the psychological ironies of threatening to fritter the apples. She feels better now, now that she fired him. But doesn't care to wait for paramedics to ignore her again, next time the secrets of relative gain find her vulnerable. "Also their will be many that are currently active and for various reasons are going to be killed/sacrificed." What like a 'cabin pentagon psychic audition winning' prescient dogpile witch burning? Didn't PnG wax on eloquently of sacrifice? [link to www.theblackvault.com] "Spectacularly crazy rickie MCfees?" as wHitlery described the only banned skinned and mutilated bunny? "No such thing as coincidence" said Puck, made Jessop a nut, added Levenda. Martin's blowing it out his cannon. Control freak controlling is very similar to torture doctoring. What diff StrugholdStraggler cognitive dissonance hypnotist mass media torturers? Time already belongs to the dead. You obviously have something important to say but your cryptic self talk isn't enlightening anyone here. just sayin' |
Anonymous Coward User ID: 385176 United States 10/15/2008 02:59 AM Report Abusive Post Report Copyright Violation | "The spiraling cost of healthcare demands that we ask ourselves, what is the value of a life? How much are we willing to spend to maintain a vegetative state of existence??" - Dannion Brinkley Quoting: torture doctors 437387There was a long thread at Unknown Country where WS argued for the death by starvation and dehydration of that lady in Florida. Funny how so many monarchs buy into the leftist political rhetoric of about "dying with dignity", which is really the fascist eugenics of those who torured them. clue: fascism and communism (left and right) come from the same "source". And, THAT is why you'll never find a monarch who supported Ron Paul, lol. |
Anonymous Coward User ID: 385176 United States 10/15/2008 03:00 AM Report Abusive Post Report Copyright Violation | from the Frankenkitty's BV thread (which is torture in itself): deathcultreject B.V. Info Seeker Joined: Oct 12, 2006 Posts: 663 Posted: Fri Sep 19, 2008 2:05 am Post subject: As far as I can see, survivers tend to be prickly people who suffer from terrible mental blocks against speaking out. If we say something suddenly, it might be because there's been a crack in the blocks against remembering or saying something. the block might come back with 'avengeance' the next day, and the anxiety could take the form of any kind of emotion strong enough to stop a person communicating or thinking straight. (usualy a negative emotion.) In the past, people have tried to make us feel discredited by demanding more information than was given during the 'remission phase' so it's a touchy subject. I think that the best way to find out what's been going on is to do some cultural equivalent of praying (or just pray) to protect and heal the survivers, but bear in mind that survivers might be very wary of all kinds of religious beliefs, not just because of past traumas, but also because other people's beliefs can seem too conceptualy crude and clumsy to deal with anything. |
Anonymous Coward User ID: 385176 United States 10/15/2008 03:37 AM Report Abusive Post Report Copyright Violation | Cracked eggs and Mutilation go together like psychologists and mental torturers, horses and carriages, social climbers and dogpilers. Quoting: torture doctors 437387They sure do. Yes, torture and doctors have been affiliated for centuries. Conclusively, he designed the new disfigurement with malevolent intelligence, intentionally to trigger psychological vulnerability. Then stipulated that to correct it, requires a complete abdication of patient control. The very thing that makes plastic surgery patients suicidal. Cutting losses is a runaway six year old's special. Who are the torture doctors you guys are talking about (names, please) and what is this surgery that you're referring to? |
Frankie User ID: 437387 Canada 10/15/2008 03:49 AM Report Abusive Post Report Copyright Violation | You obviously have something important to say but your cryptic self talk isn't enlightening anyone here. Quoting: Anonymous Coward 385176just sayin' Certainly, I don't speak for anyone else here at GLP. IMO - We hold these semantics to be self evident: " bunch of big babies." - Anne Strieber "laughing it off with rectal probe jokes." - Whitley Strieber Of cognitive dissonant subliminal baiting of the psychologically vulnerable trauma survivor, that is any form of abductee. Billy's in the basement with StrugholdStraggler's principality. [link to www.youtube.com] |
Anonymous Coward User ID: 525665 United States 10/15/2008 03:50 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 525665 United States 10/15/2008 03:52 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 385176 United States 10/15/2008 03:54 AM Report Abusive Post Report Copyright Violation | This movie is based on a "Signal" that comes over the TV / Radio which triggers the sleepers. Quoting: Xare[link to www.youtube.com] |
Anonymous Coward User ID: 385176 United States 10/15/2008 03:57 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 525665 United States 10/15/2008 04:01 AM Report Abusive Post Report Copyright Violation | onesmartrat isn't even on this thread? dunno who the OP is. don't like it, fuck off. Quoting: Anonymous Coward 385176This thread reeks of Onesmartrat and susano. I can smell them from seven hundred and seventy seven miles away, can you not? Bippity boppity boo! |
Don't Taze Me , Bro. User ID: 526707 United States 10/15/2008 04:57 AM Report Abusive Post Report Copyright Violation | |
Don't Taze Me , Bro. User ID: 526707 United States 10/15/2008 05:01 AM Report Abusive Post Report Copyright Violation | He finds his "Vitamins". (mommy, why am I so itchy?) the tiny abrasions inside her outer ear reveals to me the truth about her metabolism. (stay outta arms reach!) the message? its scrawled somewhere on the surface of one of his paintings! yeah thats right. boom, for real. DO NOT OPEN TILL XMAS!!! |
Don't Taze Me , Bro. User ID: 526707 United States 10/15/2008 05:05 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 385176 United States 10/15/2008 05:44 AM Report Abusive Post Report Copyright Violation | Look, doc Frankenstein: I think you're either working for Puck or a Munchausen's PhD like the ex husband date rape cocktail charity. Quoting: frankie 437387Every possible worst condition a plastic surgeon patient can be exposed to was experienced. 1 – Told I was getting bent bed on the first appointment – but there was no pull on the incision when I woke up flat on my back with my legs stretched out. 2 – Asked for a low incision, wasn't of interest to such a wealth of experience: "I've been doing this longer than you." Now I have to do it all again, and my belly button is between my first two ribs. 3 – Arrived with a rash, "That's only poison oak" wasn't a good enough reason to delay, just like a training cadaver. 4 – Fears of infection afterwards received a stitch in the sternum for two extra weeks. 5 – Initial disappointment met with attempts to shame "It was so grotesque before, just be grateful." 6 – Waited a six weeks to discuss "The incision will lower" and had that PTSD shocked hysterical appointment canceled – August 13th,. 7 – Arrive with a bruised hip flap end of August and ask for a revision that accommodates January employment – get a call four weeks later to cancel September's appt and book the revision for February. 8 – Express frustration at lack of control over my own body and presented with a prisoners dilemma that is certain to create psychological condition for suicidal ideation, in order to obtain a revision. "The attraction of suicide for these women may be a way to gain power over their own fates." [link to www.psychologytoday.com] And this is after I told the admitting nurse at the hospital that pre- admittance interview, that "I didn't want to live with my flap anymore." Sometimes the "master negotiators" are just jealous – of the Manchurians. You got something to say to me, put it in writing. um, do these posts indicate that you were mind controlled and then went through further trauma with an unsuccessful plastic surgery? kind of hard to follow. like reading someone's private journal (which seems creepy). |
Frankie User ID: 437387 Canada 10/15/2008 08:36 AM Report Abusive Post Report Copyright Violation | um, do these posts indicate that you were mind controlled and then went through further trauma with an unsuccessful plastic surgery? kind of hard to follow. like reading someone's private journal (which seems creepy). Quoting: Anonymous Coward 385176A demonstration of master baiting techniques. Fleurrys' de eMal Fob Not certain if it's wHitlery Strugholdstraggler or call it ham, that is the superior liar. Neither have any keys for man, Unless its for doors they made that lock them in, following torture. |


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Always enjoy stopping in and listening to your tunes! Kill it in Memphis!!
Thank you! We are going to try and get by to see you during one of your sets in Memphis!
Don't Touch My Liquor is the best song I have heard on ReverbNation. I love the band and the vocals are phrased beautifully. I won't touch your liquor when you travel through Seattle but will buy you a drink!! Check us out when you have a second.
We really enjoyed listening to "Mexico." Love your sound! If you're ever in the Nashville area let us know! We wish you all the best! - DS
Thanks so much! We just came through Nashville on the way to Mississippi last week. Next time we are in the area we will make sure to hit you guys up!
Hey.., Gooooood vibes here!!.......................
Please drop by and have a listen to our playlist if you have time ....We think you will enjoy it..x.....,TBBB
Heyyyy.. Cool stuff - like me,
The Album "MEIN BLICKWINKEL" now obtainable at Amazon and Musicload .
You will find the link on my homepage.
Good luck with your music...
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Wishing you the best with your music and have a great evening. Eddie Ray


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Pinot Noir Cahuil Vineyard is intense and with high complexity on the nose, with aromas of strawberries, red cherries and a hint of orange peel.
A great exponent of Pinot Noir, aromatically fresh and complex. A juicy, fruity and elegant wine. Bright colour. Clean and direct fruity nose, with hints of red cherries, raspberries and a subtle wild herb note. Delicate and refined on the palate. Juicy with ripe flavours of berries combined with mineral notes and a lively acidity.
Bright ruby red colour. A fruity nose with strawberries, hints of red cherries and a subtle wild herb notes with a delicate smokiness and tobacco. Refined on the palate, juicy and full of ripe berry flavours, a hint of minerality and refreshing finish.


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bio | website | novel.darknovagames.com |
location | Corpus Christi, TX | |
age | 26 | |
visits | member for | 3 years, 3 months |
seen | Apr 2 '12 at 13:51 | |
stats | profile views | 5 |
I aspire to be a video game programmer. In reality, it seems that I'll be pursuing a CE (hardware) degree, which I'm hoping will open the door to handheld gaming.
I'm fluent in C, C++, PHP, and regular old SQL. I know HTML and CSS, and work my hardest to keep my code as close to the standards as possible, except where Internet Explorer doesn't support any standard way to do what I want.
I play piano and tuba, and love to write my own music when I can find the time. My favorite video game is Final Fantasy IX.
Sep 22 |
awarded | Nice Question |
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Is it easier to play "softly" on a grand piano?
I guess I should point out: I will soon be auditioning for the music program at my college on piano, and although I'm not sure, I think the audition is on a grand piano. If that's the case, and there's a big difference, I suppose I need to go straight to that and avoid trying to adapt to the upright. |
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Does one play a song better after "sleeping on it"?
That makes a lot of sense when you think about it logically. After all, when you learn something, you're essentially creating or strengthening pathways in the brain-- those things don't grow instantly, it takes time for them to develop. The most optimal way to learn something, thus, is short daily sessions, as opposed to a few very long sessions. I think this is true regardless of discipline. |
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When singing, how to avoid being distracted by vocal harmony or other vocal lines?
This technique can fail for many types of choral music, so be careful. You'll need to be able to quickly mentally relocate your Do when the key changes. Songs that use unusual scales or that have lots of unwritten key changes with accidentals can be difficult to apply this to. (Consequently, these are the kinds of songs that I have a LOT of trouble with.) |
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answered | When singing, how to avoid being distracted by vocal harmony or other vocal lines? |
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asked | When should falsetto be used for a male voice? |
Oct 17 |
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Pacific Science Center is proud to offer two preschool programs at our main campus downtown under the arches and at Mercer Slough Environmental Education Center in Bellevue. Both programs are play-based and multi-aged for children 3 to 5 years old.
Proton Preschool
Proton Preschool is a school year program launching in January 2015 under the arches at Pacific Science Center. Using science as the catalyst for discovery and stimulation, Proton Preschool is designed to meet the developmental needs of early learners, while inspiring curiosity, cultivating a love for learning, and teaching basic science concepts all while utilizing the incredible resources Pacific Science Center has to offer. Learn more
Enrollment for the January - June 2015 session is currently full. To be added to the waitlist, please submit an application. Learn more
Polliwog Preschool
Polliwog Preschool is a school year program held at Mercer Slough Environmental Education Center in Bellevue. At Polliwog Preschool, nature-based themes and daily activities are designed to meet the developmental needs of early learners, while encouraging curiosity and fostering a love of nature and learning. Learn more


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User:Iris E. Sheu
From OpenWetWare
I am a new member of OpenWetWare!
Contents |
Contact Info
- Iris Sheu
- Email: isheu [at] mit [dot] edu
I learned about OpenWetWare from class, and I've joined because of 20.109 lab class.
- MIT Class of 2014
- Course 20
Research interests
- Tissue Engineering and Regenerative Medicine
- Goldbeter A and Koshland DE Jr. . pmid:6947258.
- JACOB F and MONOD J. . pmid:13718526.
leave a comment about a paper here - Mark Ptashne. A genetic switch. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 2004. isbn:0879697164.


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Home > News > World
Published: Saturday August 23, 2014 MYT 7:00:03 PM Updated: Saturday August 23, 2014 MYT 7:02:01 PM
ZURICH (Reuters) - A man was killed on Friday in a shooting at an Albanian mosque in St. Gallen, Switzerland, and another man was arrested, Swiss police said.
Police arrested a man with a handgun after they were called to the mosque in a suburb of the town after reports of gunfire, a spokesman for the cantonal police said.
A 51-year-old Serbian man has confessed to the shooting, police said in a statement on Saturday. The victim, also 51 years old, was a Swiss citizen with Albanian roots.
The victim's body was found in the prayer room of the mosque, the spokesman said, adding it was too early for the police to say what motive there might be for the killing.
Representatives of the El-Hidaje mosque, where the shooting took place, were not immediately available for comment. A former imam of the mosque, Fehim Dragusha, told Reuters the shooting was tied to a long-running feud between two families, whom he knew, and was not politically motivated.
"It's a personal conflict between two families, who were possibly settling a score," said Dragusha, who served as the imam of the El-Hidaje mosque for three years. "It's nothing political at all."
Roughly 400,000 Muslims live in Switzerland, about 5 percent of the population. Concern about immigration in general has been brewing in recent years in a country where foreigners make up nearly a quarter of Switzerland's population of 8 million.
People in the southern Swiss canton of Ticino voted to impose the country's first ban on face-covering veils last year.
In 2009, voters backed a ban on building new minarets and Switzerland's biggest party, the Swiss People's Party (SVP), has long made opposition to immigration a keystone of its electoral appeal.
Swiss voters narrowly backed the party's proposals to reintroduce immigration quotas with the European Union in February, calling into question Switzerland's bilateral accords with the EU.
(Reporting by Alice Baghdjian; Additional reporting by Joshua Franklin; Editing by Gareth Jones)
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Your Price: $367.36
Description of Part No. 711-5. Olympic Hydrolon paint five gallon Blue Mist.
Compatible with Chlorinated Rubber and Water Based Acrylic Only!
Compatible with these types of pools: Bare Concrete, Concrete, or Plaster. Coverage: Approximately 250 - 300 square feet per gallon.
This item cannot be overnighted! Shipped ground only. If you have any questions about shipping, please call our Customer Service Department.
Please Note: Paint is Not Returnable.
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