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Because He's Hot! Jon Hamm Sports Sexy Stubble at Lakers Game
Jon Hamm is a far cry from his clean-shaven character Don Draper now that Mad Men is on hiatus, but that's not to say we're not diggin' the facial hair!
Hailed as one of the sexiest men on television, Jon lived up to the title as he cheered for the home team on Tuesday and looked on as the Los Angeles Lakers beat the New Orleans Hornets 106-90. Dressed in a leather jacket, jeans and a button down shirt, the actor wasn't afraid to get out of his seat!
Get a good look at Jon while you can because he won't be returning to TV anytime soon.
This past March, news broke that the actor's award-winning AMC show Mad Men won't be returning for another season until 2012, leaving fans up in arms! There's also rumors swirling that the all-star cast might face some layoffs.
Meanwhile back at the game, Jon wasn't the only famous face! Soccer stud David Beckham, Entourage star Jeremy Piven and director Steven Spielberg were all at Game 5! There were also some ladies in attendance -- fashionista Whitney Port and Big Bang Theory star Kaley Cuoco showed up to cheer on their Lakers!


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**** no. I'm afraid of trains as it is.
My nickname is pronounced [kvoz/\luri]. Things I love: Dead Space, Propper (Hammer compiler), Win 8, coffee. Things I hate: TF2, Garry's mod, unnecessary graphical things like parallax and people who're praising these over anything else, and lack of real, widespread advancement in computer-user interface.
**** no. I'm afraid of trains as it is.
The gallery here says it's been a bit more than 14 months since the last [content] update. And you've just had an update about Steampipe, that one dating back less than a month ago. Sure you're counting it right? You do know that specifically ignoring updates to say there are no updates is not a great idea?
I could but I haven't decided which one I'm going to use. All of them are good in their own way (except for the cylindrical E3 one!).
I'm not even sure for how many YEARS it's been there. Maybe... 50?..
Is there a problem?
Я мог ещё озаглавить как Yay or nay?, но до меня поздновато дошло.
Believe it or not, это моя галерея, мои скрины, да и мод тоже мой - все 100% кастом-контента в нем. Я и его, прикинь, могу называть как хочу, если захочу.
Моих знаний достаточно для того, чтобы уметь выходить за рамки скучной формалистики. Заголовок тут, если угодно, есть пример крайней степени опущения [слов], оmission, что вполне уместно в инглише.
P.S. Минусовал не я.
Well I dunno guys. In this particular screenshot it looks nice but sometimes the clouds would pass before the Citadel and that's a huge 'Ugh' because fog effects and transparency and all are a bit terrible in Source 2013.
Not really. I'm not very good with making videos and especially with making trailers.
Died? Who told you that?
Hope for the continued development... I am developing. You don't need to hope that I'll continue since I just am working on it. You can check my profile here, I post smaller stuff there from time to time.
In terms of the concept - pretty much. Not so much in terms of details, gameplay, ambients, etc.
Is it you, Romanix? I did tell you not to come back, right?
>bed english
It's fine as long as you stay in the bed.
Basically it's the Leak body with Retail head put on it (the head comes from that glass jar in the Eli's lab). You can use it however you want.
Всему свое время, и российский триколор пойдет туда же. В очень скором темпе.
The archived thing is just an unfortunate nuisance. Bear with it a little longer. Oh, and while it says 'ceased development', the archiving also applies to mods that temporarily halted development (and I am developing at this very moment, so that's not the case either).
Resembles Dead Money's Ghost people very closely.
I know what that error mean, but how can entity number vary from player to player? What changes it? If there is an answer to this question, it would be an answer to the error.
I'm getting the ed_alloc error on d2_aires_02 as well now (with ed_alloc 4096, 8192 and 16384 all the same). Heh. It's sort of inconsistent and different to track down. I'll let know if I find a way to prevent it.
You mean bright red crosses everywhere? Those should be rain particles but they're not being precached, hence the engine 'missing particle' effect. Use r_drawparticles 0 console command to disable particle rendering, I'm not sure if there are other workarounds; forcing the game to precache the file needed doesn't help, and I think the problem lies in the rain tutorial from VDC (I assume the team tried to follow that tutorial).
For the ed_alloc thing, try launching the mod with command line parameter -max_edicts 4096 or -max_edicts 8192 added.
Looks nice. c17_03? Or just some apartment?
Story mods? As in, with in-game storyline being present and played through? Don't know of any, actually. Other than Missing Info if you count Borealis chapter with narrating done by a couple of voiced bits from the leak.
We've already passed the ten mods mark actually. In more or less chronological order w/o the ones pronounced dead:
1) Missing Information Moddb.com
2) Project 9 (I dunno, Hl2-beta.ru ?)
3) Old Story Moddb.com
4) Vertigo Hl2-beta.ru
5) Conscript Moddb.com
6) The Origin Moddb.com
7) Dark Interval
8) Insolence Moddb.com
9) RtB Moddb.com
10) Cremation Moddb.com
11) Depot Moddb.com
12) Town 17 Moddb.com
13) Dark Skies Moddb.com
14) Alpha Retaliation Moddb.com
And I might be forgetting some.
I wonder why haven't you mentioned Raising the Bar mod.
Have you simply forgotten, or didn't know it's there, or were you only counting presumably dead ones?
Машины надо заменять на американские 60-70х годов. Такие, как Ford Thunderbolt 1964, для него вот недавно обнаружили текстуру в бете, очень примитивную и неиспользуемую, но указывает всё на эту модель. Хотя, возможно, текстура для Thunderbird того же года, но это сомнительно, первая больше походит на остальные старые автомобили на картах стилем.
See, that's one of my problems with posting stuff that's WIP. I post it, and almost immediately make it better in some way or other.
Well, still, I think I'm heading in the right direction. Gonna work on surfaces now.
There are just lots of things the meaning of which is... mysterios at best times. In such cases I just remind myself that is has been 10 years of alien regime, and some amount of time of constant Xen invasions prior to it. So, many things could have came up. It also applies to the way many things in concepts blend (or rather don't do this well) in original City setting. I kinda love that, too. In some ways it is similar to "Blade Runner", which had some urban set pieces which were basically effeciency/function-oriented nonsense, with no damns given about whether it fits its surrounding, plus this special thing when you see pretty old, classical may I say, 'overgrown' with future tech. Because the world ended and no one cares about protecting humanity legacy now. Kinda same deal in original C17.
This all being said, I don't think that's a rebel thing. Well, except if it's out of the city, but that's doubtful. It doesn't look well defended or even hidden. Probably just some proles hiding here. Or it used to be their shelter.
mat_specular 0
mat_specular 1.
Also, try to learn a bit more about setting HDR up in Source. It takes a little more than just compiling maps with HDR settings, you also need to set up env_tonemap_controller entity to avoid the HDR getting too bright, as seen above.
Haha, but Source is old, too, to this matter.
Wow, cool! So you know your way around all tech stuff. You making you're own mod, then? Why aren't you making your own mod?
Wow, it looked like you smashed this dev guy in pieces, and he was all, like, flat, and bloodied! Did you really do that? It seemed so real. You're cool.
I'm not sure. Maybe it's 16? Source allows to have max 16 sounds per channel as I understand it, and amb_generics are on the same channel I guess. There are separate channels like CHAN_WEAPON, CHAN_VOICE, CHAN_BODY, and I suppose also for physics sounds and some else.
Sure is. The same way as with editing any particles' color. I guess I'll look into it someday. Plus, there's lots of ways to improve the fire... assign it with sounds (default HL2/Epx fires don't produce sounds on their own, the sounds are placed by level designer), add heatwave particles, maybe add fire spreading. The sound part is tricky though, when there are too many fires (i.e. if 3 or 4 cremators are fighting someone at the same time), there would be too many sounds and other sounds would be silenced.
I'm not really a person responsible for it... but yeah. The old fire just looked more alive, even. This one is just pale and... grainy, I dunno.
Battles between two gargs could be just awesome. But I personally am not so sure about fighting one in the wastes, since they show themselves best in tight, closed spaces, and when out in the open, they become fairly easy to evade. So maybe place one (or more) in some caves? Where it would break rocks, roars going echoing through the tunnels, all that.
Well, I know he designed the tech (which is SO resemblant of Combine tech), he made concept arts for game areas, dunno about characters. He is, what it's called? Art director, I think. Obviously there were other designers but you can say that Antonov made the look of the game, and it turn out to be absolute awesome. Some didn't like the game, which is totally unfathomable by me.
Erm… Dishonored is designed by Viktor Antonov who created the image of HL2 (except Ep2) back when he worked at Valve. Hence the visual similarity.
And this worked great actually.
A Sourse версия когда нбудь будет ?
I guess the Combine gets air support, choppers, gunships. Some unidentified flying vehicles dropping tripods, mentioned in the Weather control script. As I recall, the latter ones bombarded the Bradleys in the Arctic canyon rather easy.
P.S. The model is great looking. Hope there will be pretty dynamics as well; can it be destructible? Like, armor being blown off by enemy fire, explosive gibbing and such.
The child's head texture is messed up.
The lamps are lit from the ceiling instead of their own lightbulbs. Recommend making a small room outside the map with dark walls and a dim light_spot pointing up and an info_lighting placed above it, then set Lighting origin for the lamp props with the name of the info_lighting, plus putting a sprite in the lamps.
That, basically an NPC dispencer. Bit of a crude brush work, should polish those, turn into models.
Actually, the fake (or rather, prop) look of the walls and stuff makes perfect sense for Skolkovo context…
Anyway, the picture looks real nice. I wouldn't complain about the textures at all. You've got a good taste in level geometry, I can say that.
Yeah, I've probably overdid the vegetation on this map, but I don't think there can't be one at all. Ravenholm had trees, Xen flora and fauna seems more or less abundant in RtB scripts. But don't worry, the green life is made much less abundant already, and there isn't one really beyond the canals.
Actually I think that some colours may very well be quite uncomfortable for some people. I don't have problems with that sky (it's not very realistic, the way it lit, but in the same time it has some… intriguing and anxious feel in it), but e.g. the green-violet rocks texture in mappack makes my head hurt quite for real, and so does bright deep blue for example.
It's not actually that the testers were pussies, not by itself. I'd say it had more to do with Valve's perfectionism: "one person gets motion sickness - we can't allow it, cut it." And the Hydra deal was like that too - someone couldn't have fight it well, so Valve had decided that it doesn't worth polishing (hell, even I can dodge Hydra, and why not give it a more slow, swing-like attack?).
Um, not sure that I got you right. Do you ask whether it's possible to make a day/night lighting change? Well, it is possible technically but looks rather ugly as the smooth light transition on light_envrionment is broken. And if there is a same single letter pattern (i.e. mmm or www) there will be no transition obviously. So what I'm talking about is the use of this feature as a tool for tweaking.
If you (or anyone who's working with lighting) have long compile times, you can also try that: name the light sources that you're tweaking whatever you like (presumably with a same name). Next, you change their brightness in-game using ent_fire <entityname> setpattern <a-z> input. That'll let you carefully tweak the light's intensiveness, and next you just put the corresponding input into logic_auto and recompile (maybe even with -onlyents).
Oh, and the default setpattern value is m (or mmm, no matter). So for a light with 100 brightness «a» will be 1 (I think), «z» will be… 200? And «m» will be 100.
Additional ambient lighting, in terms of… raising the brighntess of the background a bit, so it's at least visible (like in nightfall) wouldn't hurt. Like, 1-2 light_spots with RGBb 100 140 190 50, and Constant around 50 000.
Ну бэк-то так, за минуту сделан. Бэк для бэка. Хотя ничего особо дурного в нем не вижу…
А я решил, что калька с бетовского — вон, спина же.
That's not my business (or is it partly? we are the people of the site and… well anyway), but I personally take it as that you are a bit overreacting. Things can be settled in a variety of ways, some of them are counter-attacking (never work in my opinion), but why choose those?
It's fine for regular maps, but sometimes it is not enough for me. And it works badly with huge models since you can't see them unless you get close to a model's center. So for example my Airex reactor model would be just a yellow cube if I look at it in Hammer from the map's floor or move away some distance.
So I see that the entities' render distance is pretty small, hm. I always set the map render distance to about 30'000 (it is beyound numbers Hammer itself has lol, so I do it via reg manipulation).
Two reasons for it. The first one is… well, why not. They are awful, they burn well, and I plan cremators for Ravenholm as well. I also doubt that they should harass citizens just like that. How I see it is that's rather, like, cremators have their «work hours» and work zones, and usually citizens don't run into them, but if you aren't careful enough, you'll get it in a dark alley.
The other thing is… if zombies aren't priority, they just tend to get close and slash slash slash a poor cremator. ) So I made mister C turn its attention to zombies and eliminate them first.
What about BM?
>The only time you will see a decrease of fog is beyond the Weather Control chapter, when the Air Exchange activity stop
And how about an ocean? Kinda figured out that the C. use the Weather Control to spread the Exchanger toxic fumes faster and farther and to get it over onto the City. Well at least that's my vision of the whole thing.
And the underground fog is… a weird stuff actually. Hot exhausts tend to go up in the atmosphere. And there were hobo camps in steam tunnels on some maps, should be breathable enough to live there… kinda. After all, think about a fog as a gameplay element too, or a gameplay _affecting_ element to be precise. I wouldn't like dwelling in a fog the whole damn time. As well as the game being almost monotone; it is obviously possible to make the picture both colorful and telling a player about toxic dangers.
Already a noon of April 2nd here, so I didn't get it until the end of the article… :D
Oh, I forgot to mention that the hollow brush should be converted to func_brush (guess you already figured this out from the fx alpha aspect, but anyway). It could be a simle hollow cube as well, but this being the case, the fog'll have a tendency to «condense» in the corners. An ideal thing will be a dome-shaped brush, but I think it doesn't worth it actually.
The buildings with their European style don't look that much «repurposed and integrated», to be honest. Although this can pass. After all, there surely are some European buildings in America.
How could it not be? It's Source. It (well, the Hl2's one at least) looks nearly identical whether you run it 2013 top PC and if you launch it on… I don't know… a stone. Just like ScarT said, the deal is with the colors. A kind of solution here is to implement a partly opague, hollow cylinder brush with tools\toolsblack texture — so the fog «from» sky_camera also casts partly (because of the partial translucency) on the brush and, therefore, on all sky. This way both the Citadel and the sky texture will become fogged with the same color. The most important detail here is to not make the skybrush-fog too intensive so it wouldn't just hide the texture behind it. So one should set the FX Alpha for the brush for… I'd say, 150. Well, you can change it in-game realtime with env_fire *** alpha <0-255> input to see which one will be a better fit.
Hope this helps.
The map went through so many variations that I think it has bits from all maps. Underground shafts with scanners from e3_industrial, starting area with smart gates from e3, streets and factories from early builds… everything.
Well, it only looks like this because there isn't a normal map for the model texture. When an env_projectedtexture casts light on a model with texture without a normal map, a z-buffer effect occurs. Easily fixable and it doesn't even matter until the release.
Really, AI problems are much more serious for me. Those imbecile stalkers and all.
>I didn't say everything. Stop taking things so personal.
All right. Excuse me for being instantly rude, then.
That's why I don't post updates. There're always two users who say that everything looks like ****, the lightning, the textures…
And I am going to use this lighting wherever I want, actually. You probably should be more concerned about your HDR and E3 crap.
Ah, wait, I mistook it with Camocity.
You just put them in the mod's root folder.
There is the readme file.
Huh. I would say that this is actually based a little too freely on the concept.
Erm... which concept is remade here?..
Correct, so this is a start (or pre-start, so to say) to the Airex chapter. After the train crash Alyx leads us through a riverbed to a dam (under a pressure from Combine patrols in the region) and then through tunnels to a cliff road which leads to the Alyx's stash, by the time Gordon exits the stash it's evening with red dying sun, so time on maps is correlated.
The Sector 17 logo is on a wrong side of the tower, like in ШЛЫК's mod. I did'nt have a chance to tell him in the time, but I will not loose this chance this time.
P.S. I love the sky.
Well, snipers were nothing like that. They were either robots or like soldiers but with more massive camo suit, and a sniper on Borealis makes even less sense then a cremator, while it is not absurd for Combine soldiers to bring a cremator upon the ship to clean up the mess if Combine were planning to re-use the ship. And they did bring stalkers and alien assassins with them.
Размытые текстуры это олдскульно же. Древний графон.
Вообще, мы не показыаем слишком хороший графон, чтобы он оставался козырем на будущее.
Брашь пола\стен\чего угодно должна быть вот этой ентитью, и текстура на ней должна иметь соответствующий шейдер и параметры. Для примера смотри materials\glass\reflectiveglass002.vmt
func_reflectiveglass же! Это совершенно реалтаймовые отражения.
Самая что ни на есть совьет скамейка. RAZOR1703 очевидно не признаёт её потому, что СССР закончилось задолго до него…
Мрамор для Вертиго-Паласа, ржавь и грязные окна для города, камни и кости для Пустоши…
Nope. Какой это спойлер, это же и так все знают.
а) я таки не заглядывал на крематорскую фабрику.
б) они не нужны. Зачем?
в) они будут сделаны потом. Бесайдс, в Разломе им особо делать нечего, да и по улицам шляться не положено.
Great, reminds me of some of Antonov's steampunk works like Vulcanobros.

subset: commoncrawl


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Cooperative User - Network Interactions in Next Generation Communication Networks
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Executive Summary
Next Generation Communication Networks employ the idea of convergence, where heterogeneous access technologies may coexist, and a user may be served by anyone of the participating access networks, motivating the emergence of a Network Selection mechanism. The triggering and execution of the Network Selection mechanism becomes a challenging task due to the heterogeneity of the entities involved, i.e., the users and the access networks. This heterogeneity results in different and often conflicting interests for these entities, motivating the question of how they should behave in order to remain satisfied from their interactions. This paper studies cooperative user-network interactions and seeks appropriate modes of behaviour for these entities such that they achieve own satisfaction overcoming their conflicting interests.
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by James Matthews
A modular home being transported along US Highway 19-23 crashed into a bridge Monday morning (January 19).
The home, which was being transported via truck, struck the Weaver Boulevard US Highway 25-70 bridge that spans Future I-26, and continued without stopping. Read more...
Debris from the home's roofline was left strewn across the highway as well as stuck to the underside of the bridge. The Weaverville Fire and Police Departments, the Buncombe County Sheriff's Office and the NC State Highway Patrol all responded, shutting down one lane of traffic while the roadway was cleaned. Weaverville Fire Department Battalion Chief Tim Laster stated that as the department responded, they drove southbound along US 1923 and spotted two stopped vehicles. However, after turning around and coming back up US 19-23, those vehicles had left the scene. "Obviously no one was hurt." Laster did mention that according to a State Highway Patrol Motor Carrier Enforcement Officer, "There's no mobile homes permitted to move today, because today is a holiday," he said referencing Martin Luther King Jr. Day. "Looking at the shingles," he said, "it appears to be a used [mobile home]." A NC Department of Transportation engineer arrived and after a brief inspection stated that the bridge was undamaged and safe. The roadway was opened soon after.
Following two continuances, the Weaverville Town Council announced Friday (January 9) that the town manager would be resigning.The announcement came after a nearly two-hour closed session. The council then reconvened in the council chambers at Town Hall, where Mayor Dottie Sherrill read a prepared statement addressing the issue. Read more...
"Town Manager, James Michael Boaz, has resigned as Town Manager effective January 16, 2015, to explore other opportunities. Mr. Boaz is currently out of the office. In accordance with NC General Statute 160A-149, Mr. Boaz has designated Police Chief Greg Stephens as the acting Town Manager during Mr. Boaz's absence from the office."Sherrill went on to state, "Town Council has designated former Town Manager, Michael J. Morgan, to act as interim Town Manager, in accordance with NC General Statute 160A150, effective January 17, 2015, until another Town Manager is selected by Town Council." The statement concluded, "Town Council appreciates Mr. Boaz and all of his hard work on behalf of the Town of Weaverville and wish him well in his future endeavors."
For the rest of the story, pick up a copy of this weeks Weaverville Tribune.
December 2014
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The Irish Songbook
75 Songs from the Clancy Brothers
By The Clancy Brothers
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The Irish Songbook (75 Songs from the Clancy Brothers). By The Clancy Brothers. For Melody/Lyrics/Chords. Music Sales America. Irish, Folk, Celtic. Softcover. 186 pages. Music Sales #OK64188. Published by Music Sales (HL.14016248).
ISBN 0825602378. Irish, Folk, Celtic. 9x12 inches.
75 songs collected, adapted, written and sung by the Clancy Brothers and Tommy Makem. Piano/vocal plus chords. Illustrated.
- A Man Of Double Deed
- An Poc Ar Buile
- Ar Fol Lol O
- As I Roved Out
- Blackwater Side
- Blow Ye Winds
- Bold Tenant Farmer
- Boulavogue
- Bungle Rye
- Convict Of Clonmel
- Cruiscin Lan
- Eamann An Chnoic
- Eileenn Aroon
- Ever The Winds
- Fare Thee Well, Enniskillen
- Foggy Dew
- Four Green Fields
- Freedom's Sons
- Galway City
- Galway Races
- Hi For The Beggarman
- I Once Loved A Lass
- Index Of Recordings
- Irish Rover
- Isn't It Grand, Boys?
- Johnny Is A Roving Blade
- Johnny, I Hardly Knew Ye
- Lament For Brendhan Behan
- Lord Nelson
- Maderine Rue
- Maid Of Fife-E-O
- Master McGrath
- McPherson's Lament
- Mick McGuire
- Mr. Moses Ri-tooral-ay
- Mrs. Rockett's Pub
- My Son Ted
- Nancy Whiskey
- Nell Flaherty's Drake
- O'donnel Abu
- Oro, Se Do Bheatha 'Bhaile!
- Paddy Doyle's Boots
- Paper Of Pins
- Portlairge
- Redmond O'hanlon
- Rocky Road to Dublin
- Sally-o
- The 23rd Of June
- The Bard Of Armagh
- The Beggarman
- The Black Cavalry
- The Butcher Boy
- The Cobbler
- The Cockees Of Bungaree
- The Croppy Boy
- The Curlew's Song
- The Earl Of Moray
- The Holy Ground
- The Leaving Of Liverpool
- The Lough Neagh Fishers
- The Lowlands Of Holland
- The Maid Of Sweet Brown Knowe
- The Month Of January
- The Old Orange Flute
- The Parting Glass
- The Rapparee
- The Rocks Of Bawn
- The Wild Rover
- The Wind That Shakes The Barley
- The Wren Song
- Weela Wallia
- What Would You Do If You Married A Soldier?
- When I Was Young
- Whiskey, You're The Devil
- William Bloat
- Winds Of Morning
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The Irish Songbook
75 Songs from the Clancy Brothers
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75 Songs from the Clancy Brothers
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The Event Services Department handles the scheduling needs for almost all on-campus activities and the Student Union with efficiency and skill. With ten meeting rooms in the Student Union, table rentals, the SPX Gym, South Campus, the 7th Street BBQ pits and volleyball area, 9th Street Plaza, classroom locations, and the Art Quad, there are many places on campus to hold an event. In addition to all of this, Event Services also arranges for the rental and use of audio, visual, and lighting equipment. Call the Event Services Office at (408) 924-6300 to schedule a room or table.


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The Flagler County Sheriff's Office is asking for the public's help in identifying a vehicle used in an April burglary.
Detective said the burglary happened on Colchester Lane in Palm Coast. They said a black Dodge Charger was used.
The car was seen in video surveillance footage.
Witnesses told detectives that a black teen, between 16 and 19 years old, who stands about 5 feet 10 inches tall and has a thin build. Witnesses said he was wearing a white shirt and black shorts.
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In the previous movie we learned to use grep to search by using a simple text string as our search expression. Grep becomes even more powerful once we learn to use regular expressions. Now there is a lot to learn about regular expressions. We can have an entire course on them, and we won't too in-depth here, but in this movie we will cover the most essential concepts so that you can apply them and use them with grep. To begin with notice that in the Terminal I'm inside my user directory and I'll just change it to my unix_files directory. And the file that we're going to start by working with is the same fruit.txt file that we're working with in the last movie.
It's just a simple list of fruit that we can search inside of and see how regular expressions work. To begin with we saw that we can grep for apple inside fruit.txt. First thing I want to tell you about regular expressions is that it's a good idea to put quotes around it. Now they are not strictly required, you saw it worked just fine without them, but it's a good idea. And the reason why is because when we start working with regular expressions we're going to be using some special regular expression symbols. And some of those regular expression symbols also have a meaning to the Unix command line and by putting it in quotes we're helping the Unix command line to see ah, this is the expression.
The symbols that I see in there they are not for me to interpret and for me to do things with. They're meant to be part of the regular expression. So the single quotes are good habit to be in. Now the string that we've been searching for, apple, that is a regular expression. It's the simplest regular expressions that you can have, because it matches only the literal characters apple. Instead what we want to do is be able to provide some variation to that. So for example, we can replace those p's with periods. The period is a wild card character for regular expressions.
It says any character could match here. So now we're not just looking for apple we're looking for a followed by any character, followed by any other character, followed by l and e. It has to be 2 character. It can't be 1, but 2 characters, but we don't care what those characters are. So now it matches not just apple, but it matches ankle. Now it's not that useless in this case, because it really just does match apple just the same, but let's try another example. Let's do grep that file for .a.a.a inside fruit. Do you know what it's going to return? Now we get back both banana and papaya.
The reason why is because each of them matches the pattern that we've described. Any character followed by an a, any character followed by an a, and then any character followed by an a, and both of them match this pattern. And that's really what we're doing with regular expressions. We're defining patterns that we want to use for searching. So you can think of that. You can think of regular expressions as ways of defining patterns that we want to search for. Let's try another one let's just grep the file for e and a together, all right so, anytime that we have ea together. So it returned pear, peach, pineapple, and pear.
Now if we wanted to just get pear and peach, we can just put a p at the beginning, right? And that would rule out pineapple. That would no longer match our pattern, but if we wanted to get peach and pineapple and omit pear how we go about doing that? Well, we can say for example that we want the third character after the e and a to match either c or p, but not the r. Now you can see it returns peach and it returns pineapple, but it didn't return pear. We're going to talk more about the square brackets, but I want you to just understand the concept that what we're doing here is we're defining a pattern that we wanted to match and both eac and eap match our pattern.
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text: hmm, ergot, its been a good while since ive heard anything about that mentioned. Thanks for refreshing my memory on the subject. I do believe that is some circumstances that this would have been the cause of supposed witch curses, at the same time you have to note that science today does not have all of the knowledge that was there at that time and of the knowledge lost alot could be related to the occult things like witchcraft. Im sure youve heard of voodoo priests and zombie powder hmm? Be that as it may there could very well have been people versed enough in strange forms of science to create concoctions of varied enough sorts to cause alot of the things associated with witch craft sans the outright absurd(flying etc.) If memory serves I also believe that there is a disease that science has recently begun to associate with the legends of vampirism, its the one where the symptoms involve a pale complexion and extreme sensitivity to sunlight.


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27 November 2014 - 03:56 PM
Haven't been active on the forums for a while, but been lurking occasionally.
Saw this on another forum, and couldn't resist sharing!
21 February 2014 - 09:35 PM
Just been wondering - have any of you seen a FOC member (or other ford forum member) drive round near you on a few occasions/regularly?
Personally I am yet to see a FOC member, but I have seen an Orange Focus ST Mk2 with a Focus STOC.com sticker on the rear window many times.
09 January 2014 - 08:31 AM
Warning: Probably NSFW.
Read the headline, and then read the comments at the bottom, some of them are hilarious.
20 December 2013 - 08:04 PM
So today I saw this, and couldn't resist the temptation to take a picture:
Personally for me, this is the oldest police car I have ever seen in my county. Anyone seen older, still in use?
16 December 2013 - 08:03 PM
Hi guys,
Could someone please photoshop my car, and replace the current alloys with standard Focus steelies without the hubcaps?
I mean these sorta ones: (doesn't have to be those)
My car:


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DrunkSide Jedi
Junior Member
Just something I was thinking about earlier today. One of my favorite pairs in bottom-lane is Alistar and Trist since Trist has a lot of early game burst that can take advantage of the oppertunities that Alistar can create with his CC. But this pair has a flaw, in that they both have skills that push the lane, Trist's and Alistar's E so they become gank targets. But wait a second - they both have displacement skills as well. So my question is if a ganker were to enter from river near side, would Alistar's Headbutt followed by Trist's Buster Shot be enough to throw him under your own turret for a Rocket Jump or a Flash + Pulverize? And even if not, does it seperate the ganker from the enemy laners long enough to pull off a countergank? I'm curious if anyone has pulled this off with Trist + Alistar - how reliable is it?
Senior Member
the target gets knockbacked a huge distance but it needs good timing else alistar is charging with his target which end deadly. its basicly the same with vayne e and alistars w.
You can push the target from river into your tower.


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- The Justin Bieber meltdown continues: a male neighbor and the slowly-unraveling pop star had a "verbal altercation" yesterday because he was racing a Ferrari up and down the street. He's now been accused of battery by the neighbor but TMZ's sources say he never touched the guy. Sigh. [TMZ, Celebitchy]
- Hayden Panettiere is secretly engaged to her giant of a boyfriend, Ukrainian boxer Wladimir Klitschko. Reminder: she is 5-foot-2 and he is 6-foot-6. Those are going to be some awkward wedding photos. [US Weekly]
- Rachel McAdams has supposedly been calling up Ryan Gosling and "using him as a shoulder to cry on" after her split with Michael Sheen. Scandale! [Hollyscoop]
- Ugh, J.Lo, why are you hanging out with Chris Brown? Why, why, why? [World Of Wonder] Keep reading »
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Publications (191)826.77 Total impact
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ABSTRACT: Titanium has been widely used as a dental implant material. However, it takes several months for the implant body to bind with the jawbone. To develop new bioactive modification on titanium surfaces to achieve full osseointegration expeditiously, we used fibrinogen and fibronectin as bioactive scaffolds on the titanium plate, which are common extracellular matrix (ECM) proteins. We analyzed the features of the surface of ECM-modified titanium plates by atomic force microscopy and Fourier transform infrared spectrophotometry. We also evaluated the effect of ECM modification on promoting the differentiation and mineralization of osteoblasts on these surfaces. Fibrinogen had excellent adsorption on titanium surfaces even at low concentrations, due to the binding ability of fibrinogen via its RGD motif. The surface was composed of a fibrinogen monolayer, in which the ratio of β-sheets was decreased. Osteoblast proliferation on ECM-modified titanium surface was significantly promoted compared with titanium alone. Calcification on the modified surface was also accelerated. These ECM-promoting effects correlated with increased expression of bone morphogenetic proteins (BMPs) by the osteoblasts themselves and were inhibited by Noggin, a BMP inhibitor. These results suggest that the fibrinogen monolayer-modified titanium surface is recognized as bioactive scaffolds and promotes bone formation, resulting in the acceleration of osseointegration.Materials Science and Engineering C 01/2015; 46:86–96. · 2.74 Impact Factor -
Article: Polarization of osteoclasts on dental implant materials is similar to that observed on bone
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ABSTRACT: Objective Polarized osteoclasts form sealing zones, (also called clear zones) detectable as actin rings, and ruffled borders to resorb bone. They secrete protons and catabolic enzymes, including tartrate-resistant acid phosphatase (TRAP), through the ruffled borders. We previously reported that polarized osteoclasts develop areas of TRAP activity (TRAP-marks) when cultured on dentin slices [11]. In this study, we examined how osteoclasts recognize dental implant materials. Methods Osteoclasts obtained from murine co-cultures were cultured on implant materials such as titanium (Ti), alumina, zirconia, and sintered hydroxyapatite (sHA), in addition to dentin. Osteoclasts were also treated with reveromycin A (RM-A), which specifically acts on polarized osteoclasts and induces apoptosis. Polarization of osteoclasts cultured on implant materials was evaluated by measuring actin rings, TRAP-marks, and reveromycin A-induced apoptosis. Results Osteoclasts formed actin rings on all substrates examined. The formation of actin rings on Ti by osteoclasts was inhibited by the GRGDS peptide, but not by the GRGES peptide, suggesting an integrin-mediated polarization of osteoclasts on Ti. Calcitonin, an inhibitory hormone of osteoclast function, disrupted the actin rings that were preformed on Ti and sHA. Osteoclasts put TRAP-marks on sHA and dentin and formed resorption pits on dentin, but failed to form resorption pits on sHA. RM-A induced apoptosis in osteoclasts cultured on Ti and sHA; this was suppressed by calcitonin. Conclusions These results demonstrate that osteoclasts are able to polarize on dental implant materials similar to the polarization observed on bone.Journal of Oral Biosciences 08/2014; - [Show abstract] [Hide abstract]
ABSTRACT: Body surface tissues, such as the oral cavity, contact directly with the external environment and are continuously exposed to microbial insults. Cathelicidins are a family of antimicrobial peptides that are found in mammalian species. Humans and mice have only one cathelicidin. Cathelicidins are expressed in a variety of surface tissues. In addition, they are abundantly expressed in bone and bone marrow. Infectious stimuli upregulate the expression of cathelicidins, which play sentinel roles in allowing the tissues to fight against microbial challenges. Cathelicidins disrupt membranes of microorganisms and kill them. They also neutralize microbe-derived pathogens, such as lipopolysaccharide (LPS) and flagellin. Besides their antimicrobial functions, cathelicidins can also control actions of host cells, such as chemotaxis, proliferation, and cytokine production, through binding to the receptors expressed on them. LPS and flagellin induce osteoclastogenesis and the production of cathelicidins, which can in turn inhibit osteoclastogenesis. Thus, cathelicidins contribute to maintaining microbiota-host homeostasis and promoting repair responses to inflammatory insults. In this review, we describe recent findings on the multiple roles of cathelicidins in host defense. We also discuss the significance of the human cathelicidin, LL-37, as a pharmaceutical target for the treatment of inflammation and bone loss in infectious diseases, such as periodontitis.Odontology / the Society of the Nippon Dental University. 07/2014; - [Show abstract] [Hide abstract]
ABSTRACT: Osteoclasts, the multinucleated cells that resorb bone, originate from monocyte-macrophage lineage cells. Various hormones, cytokines and growth factors are involved in osteoclastogenesis, via interaction with osteoblasts. In this review, we summarize the regulatory mechanism of bone resorption by various cytokines derived from osteoblasts and hematopoietic inflammatory cells.Clinical calcium 06/2014; 24(6):837-44. -
Dataset: srep04493-s1
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ABSTRACT: [This corrects the article DOI: 10.1038/bonekey.2013.229.].BoneKEy reports. 02/2014; 3:522. - [Show abstract] [Hide abstract]
ABSTRACT: Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. Here, we showed that arctigenin inhibited the action of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), a key transcription factor for osteoclastogenesis. NFATc1 in osteoclast precursors was activated through two distinct pathways: the calcineurin-dependent and osteoblastic cell-dependent pathways. Among the several lignan-derived compounds examined, arctigenin most strongly inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast-like cell formation in mouse bone marrow macrophage (BMM) cultures, in which the calcineurin-dependent NFATc1 pathway was activated. Arctigenin suppressed neither the activation of nuclear factor κB and mitogen-activated protein kinases nor the up-regulation of c-Fos expression in BMMs treated with RANKL. However, arctigenin suppressed RANKL-induced NFATc1 expression. Interestingly, the treatment of osteoclast-like cells with arctigenin converted NFATc1 into a lower molecular weight species, which was translocated into the nucleus even in the absence of RANKL. Nevertheless, arctigenin as well as cyclosporin A (CsA), a calcineurin inhibitor, suppressed the NFAT-luciferase reporter activity induced by ionomycin and phorbol 12-myristate 13-acetate in BMMs. Chromatin immunoprecipitation analysis confirmed that arctigenin inhibited the recruitment of NFATc1 to the promoter region of the NFATc1 target gene. Arctigenin, but not CsA suppressed osteoclast-like cell formation in co-cultures of osteoblastic cells and bone marrow cells, in which the osteoblastic cell-dependent NFATc1 pathway was activated. The forced expression of constitutively active NFATc1 rescued osteoclastogenesis in BMM cultures treated with CsA, but not that treated with arctigenin. Arctigenin also suppressed the pit-forming activity of osteoclast-like cells cultured on dentin slices. These results suggest that arctigenin induces a dominant negative species of NFATc1, which inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways.PLoS ONE 01/2014; 9(1):e85878. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Calcification (biomineralization) is essential for maintenance of a life. The elucidation of "Osteoclast-mediated demineralization of biomineral" directly links elucidation for bone mineral balance (coupling of bone tissue) . Bone is continuously destroyed and reformed in vertebrates to maintain bone volume and calcium homeostasis. In this review, we summarize the regulatory mechanism of osteoclast-mediated demineralization of biomineral by osteoblast-derived osteoclast differentiation factor (RANKL).Clinical calcium 01/2014; 24(2):215-23. - [Show abstract] [Hide abstract]
ABSTRACT: Wnt regulates bone formation through β-catenin-dependent canonical and -independent noncanonical signaling pathways. However, the cooperation that exists between the two signaling pathways during osteoblastogenesis remains to be elucidated. Here, we showed that the lack of Wnt5a in osteoblast-lineage cells impaired Wnt/β-catenin signaling due to the reduced expression of Lrp5 and Lrp6. Pretreatment of ST2 cells, a stromal cell line, with Wnt5a enhanced canonical Wnt ligand-induced Tcf/Lef transcription activity. Short hairpin RNA-mediated knockdown of Wnt5a, but not treatment with Dkk1, an antagonist of Wnt/β-catenin signaling, reduced the expression of Lrp5 and Lrp6 in osteoblast-lineage cells under osteogenic culture conditions. Osteoblast-lineage cells from Wnt5a-deficient mice exhibited reduced Wnt/β-catenin signaling, which impaired osteoblast differentiation and enhanced adipocyte differentiation. Adenovirus-mediated gene transfer of Lrp5 into Wnt5a-deficient osteoblast-lineage cells rescued their phenotypic features. Therefore, Wnt5a-induced noncanonical signaling cooperates with Wnt/β-catenin signaling to achieve proper bone formation.Scientific Reports 01/2014; 4:4493. · 5.08 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Cathelicidin-related antimicrobial peptide (CRAMP) not only kills bacteria but also binds to lipopolysaccharide (LPS) to neutralize its activity. CRAMP is highly expressed in bone marrow. The expression of CRAMP is reported to be upregulated by inflammatory and infectious stimuli. Here, we examined the role of CRAMP in murine osteoclastogenesis. Osteoclasts were formed in cocultures of osteoblasts and bone marrow cells in response to 1α,25-dihydroxyvitamin D3 [1α,25(OH)2 D3 ], prostaglandin E2 (PGE2 ), and Toll-like receptor (TLR) ligands such as LPS and flagellin through the induction of receptor activator of nuclear factor-κB ligand (RANKL) expression in osteoblasts. CRAMP inhibited the osteoclastogenesis in cocultures treated with LPS and flagellin, but not with 1α,25(OH)2 D3 or PGE2 . Although bone marrow macrophages (BMMs) highly expressed formyl peptide receptor 2 (a receptor of CRAMP), CRAMP showed no inhibitory effect on osteoclastogenesis in BMM cultures treated with RANKL. CRAMP suppressed both LPS- and flagellin-induced RANKL expression in osteoblasts and tumor necrosis factor-α (TNFα) expression in BMMs, suggesting that CRAMP neutralizes the actions of LPS and flagellin. LPS and flagellin enhanced the expression of CRAMP mRNA in osteoblasts. Extracellularly added CRAMP suppressed LPS- and flagellin-induced CRAMP expression. These results suggest that the production of CRAMP promoted by LPS and flagellin is inhibited by CRAMP released by osteoblasts through a feedback regulation. Even though CRAMP itself has no effect on osteoclastogenesis in mice, we propose that CRAMP is an osteoblast-derived protector in bacterial infection-induced osteoclastic bone resorption. This article is protected by copyright. All rights reserved.Immunology 07/2013; · 3.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Colony-stimulating factor-1 (CSF-1) is widely expressed and considered to regulate the development, maintenance, and function of mononuclear phagocyte lineage cells such as monocytes, macrophages, dendritic cells (DCs), Langerhans cells (LCs), microglia, and osteoclasts. Interleukin-34 (IL-34) was recently identified as an alternative ligand for the CSF-1 receptor (CSF-1R) through functional proteomics experiments. It is well established that the phenotype of CSF-1R-deficient (CSF-1R(-/-)) mice is more severe than that of mice bearing a spontaneous null mutation in CSF-1 (CSF-1(op/op)). CSF-1R(-/-) mice are severely depleted of macrophages and completely lack LCs, microglia, and osteoclasts during their lifetime. In contrast, CSF-1(op/op) mice exhibit late-onset macrophage development and osteoclastogenesis, whereas they show modestly reduced numbers of microglia and a relatively normal LC development. In contrast, IL-34-deficient (IL-34(-/-)) mice show a marked reduction of LCs and a decrease in microglia. IL-34 and CSF-1 display different spatiotemporal expression patterns and have distinct biological functions. In this review, we focus on the functional similarities and differences between IL-34 and CSF-1 in vivo.Journal of Bone and Mineral Metabolism 06/2013; · 2.22 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Objectives The purpose of this study was to assess the association between the cortical shape of the mandible, as detected on panoramic radiographs, and trabecular bone structure, as assessed by cone-beam computed tomography (CBCT), in Japanese adults. Methods Panoramic radiographs and CBCT images of the mandibles of 50 subjects (18 men, 32 women), aged 45–86 years, were evaluated. An experienced oral and maxillofacial radiologist categorized the cortical shape of the mandible as detected on panoramic radiographs as normal, mildly to moderately eroded, and severely eroded cortices, respectively. All mandibles were scanned using CBCT. Four bone structure parameters of the basal portion of the mandible were calculated in three dimensions using an image-analysis system: total bone volume (mm3); cortical bone volume fraction (%); trabecular bone volume fraction (%); fractal dimension. One-way analysis of covariance with Bonferroni correction was employed to evaluate differences in the four bone parameters among the three cortical shape groups. Pearson's correlation coefficient was calculated to examine correlations between age and cortical and trabecular bone volume fractions. Results Progression of cortical bone erosion was significantly associated with increased trabecular bone volume fraction (P < 0.001) and increased fractal dimension (P = 0.01). Cortical bone volume fraction decreased significantly with age (P = 0.04). However, trabecular bone volume fraction tended to increase with age (P = 0.06). Conclusions The change in the trabecular bone structure of the mandible may differ from that of the general skeleton in Japanese adults.Oral Radiology 05/2013; · 0.15 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Objectives: Eroded inferior cortex of the mandible detected on panoramic radiographs is useful for identifying individuals with an increased risk of osteoporosis. However, there is no previous study about the association between this cortical porosity and trabecular structures of the mandible. We assessed this association in Japanese men and women by using cone beam CT (CBCT). Methods: Of CBCT images that were taken for the diagnosis of oral and maxillofacial diseases in Matsumoto Dental University Hospital, those of 16 men and 31 women aged 45 years and older who had also panoramic radiographs were used in this study. Matsumoto Dental University human subject committee reviewed and approved the study protocol. Cortical shape of the mandible was classified into 3 groups (normal, moderately eroded, and severely eroded) according to the previous study. Trabecular structures of the basal portion of the mandible between mental foramen and second molar were analyzed using TRI/3D-BON system (Ratoc System Engineering Co., Tokyo) on CBCT images. One way-ANOVA was used to evaluate the association between 3 cortical shapes and several parameters of trabecular bone of the mandible. Results: There was no significant differences in the whole bone volume among 3 cortical shapes (P=0.79). Subjects with severely eroded cortex had significantly larger trabecular bone volume (P=0.002), trabecular bone density (P=0.047) and fractal dimension (P=0.01) than those with normal and moderately eroded cortices. The rate of cortical bone volume significantly decreased with age (P=0.03). However, trabecular bone density significantly increased with age (P=0.04). Conclusions: Our results suggested that trabecular bone density and complexity of the mandible may increase with the progression of cortical bone porosity in the elderly.IADR/AADR/CADR General Session and Exhibition 2013; 03/2013 - [Show abstract] [Hide abstract]
ABSTRACT: Tetracyclines such as doxycycline and minocycline are used to suppress bacterial growth in patients with inflammatory diseases. Tetracyclines have been shown to prevent bone loss, but the underlying mechanisms are unknown. Osteoclasts and dendritic cells (DCs) are derived from common progenitors such as bone marrow-derived macrophages (BMMs). Here, we showed that minocycline converts the differentiation pathway, which results in DC-like cells and not osteoclasts. Minocycline inhibited the receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis of BMMs but had no effects on cell growth and phagocytic activity. It influenced neither the proliferation nor differentiation of bone-forming osteoblasts. Surprisingly, minocycline induced the expression of DC markers, CD11c and CD86, in BMMs in the presence of RANKL. STAT5 is involved in DC differentiation that is induced by granulocyte–macrophage colony-stimulating factor (GM-CSF). Midostaurin, which is a STAT5 signaling inhibitor and an anti-GM-CSF neutralizing antibody, suppressed the differentiation that was induced by GM-CSF but not by tetracyclines. In vivo, the injection of minocycline into RANKL-injected mice and RANKL-transgenic mice suppressed RANKL-induced osteoclastogenesis and promoted the concomitant appearance of CD11c-positive cells. These results suggest that minocycline prevents bone loss that is induced by local inflammation, including rheumatoid arthritis and periodontitis, through osteoclast-DC-like cell conversion.Journal of Oral Biosciences 02/2013; 55(1):16–22. - [Show abstract] [Hide abstract]
ABSTRACT: To date, parathyroid hormone is the only clinically available bone anabolic drug. The major difficulty in the development of such drugs is the lack of clarification of the mechanisms regulating osteoblast differentiation and bone formation. Here, we report a peptide (W9) known to abrogate osteoclast differentiation in vivo via blocking receptor activator of nuclear factor-κB ligand (RANKL)-RANK signaling that we surprisingly found exhibits a bone anabolic effect in vivo. Subcutaneous administration of W9 3 times per day for 5 days significantly augmented bone mineral density in mouse cortical bone. Histomorphometrical analysis showed a decrease in osteoclastogenesis in the distal femoral metaphysis and a significant increase in bone formation in the femoral diaphysis. Our findings suggest that W9 exerts bone anabolic activity. To clarify the mechanisms involved in this activity, we investigated the effects of W9 on osteoblast differentiation/mineralization in MC3T3-E1 (E1) cells. W9 markedly increased alkaline phosphatase (ALP, a marker enzyme of osteoblasts) activity and mineralization as shown by alizarin red staining. Gene expression of several osteogenesis-related factors was increased in W9-treated E1 cells. Addition of W9 activated p38 MAP kinase and Smad1/5/8 in E1 cells, and W9 showed osteogenesis stimulatory activity synergistically with BMP-2 in vitro and ectopic bone formation. Knockdown of RANKL expression in E1 cells reduced the effect of W9. Furthermore, W9 showed weak effect on RANKL-deficient osteoblasts in ALP assay. Taken together, our findings suggest that this peptide may be useful for the treatment of bone diseases and W9 achieves its bone anabolic activity through RANKL on osteoblasts accompanied by production of several autocrine factors.Journal of Biological Chemistry 01/2013; · 4.60 Impact Factor -
Dataset: 9fcfd5046b81d5136f s 23da2
- [Show abstract] [Hide abstract]
ABSTRACT: Periodontitis, an inflammatory disease of periodontal tissues, is characterized by excessive alveolar bone resorption. An increase in the receptor activator of nuclear factor-κB ligand (RANKL) to osteoprotegerin (OPG) ratio is thought to reflect the severity of periodontitis. Here, we examined alveolar bone loss in OPG-deficient (OPG(-/-)) mice and RANKL-overexpressing transgenic (RANKL-Tg) mice. Alveolar bone loss in OPG(-/-) mice at 12 weeks was significantly higher than that in RANKL-Tg mice. OPG(-/-) but not RANKL-Tg mice exhibited severe bone resorption especially in cortical areas of the alveolar bone. An increased number of osteoclasts was observed in the cortical areas in OPG(-/-) but not in RANKL-Tg mice. Immunohistochemical analyses showed many OPG-positive signals in osteocytes but not osteoblasts. OPG-positive osteocytes in the cortical area of alveolar bones and long bones were abundant in both wild-type and RANKL-Tg mice. This suggests the resorption in cortical bone areas to be prevented by OPG produced locally. To test the usefulness of OPG(-/-) mice as an animal model for screening drugs to prevent alveolar bone loss, we administered an antimouse RANKL antibody or risedronate, a bisphosphonate, to OPG(-/-) mice. They suppressed alveolar bone resorption effectively. OPG(-/-) mice are useful for screening therapeutic agents against alveolar bone loss.Endocrinology 01/2013; · 4.72 Impact Factor -
Article: Vertical Ridge Augmentation Using Allograft and Synthetic Hydroxyapatites After Strategic Extraction
Clinical Advances in Periodontics. 01/2013; - [Show abstract] [Hide abstract]
ABSTRACT: Bone-resorbing osteoclasts are formed from a monocyte/macrophage lineage under the strict control of bone-forming osteoblasts. So far, macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG) produced by osteoblasts play major roles in the regulation of osteoclast differentiation. Recent studies have shown that osteoblasts regulate osteoclastogenesis through several mechanisms independent of M-CSF, RANKL, and OPG production. Identification of osteoclast-committed precursors in vivo demonstrated that osteoblasts are involved in the distribution of osteoclast precursors in bone. Interleukin 34 (IL-34), a novel ligand for c-Fms, plays a pivotal role in maintaining the splenic reservoir of osteoclast-committed precursors in M-CSF deficient mice. IL-34 is also able to act as a substitute for osteoblast-producing M-CSF in osteoclastogenesis. Wnt5a, produced by osteoblasts, enhances osteoclast differentiation by upregulating RANK expression through activation of the non-canonical Wnt pathway. Semaphorin 3A produced by osteoblasts inhibits RANKL-induced osteoclast differentiation through the suppression of immunoreceptor tyrosine-based activation motif signals. Thus, recent findings show that osteoclast differentiation is tightly regulated by osteoblasts through several different mechanisms. These newly identified molecules are expected to be promising targets of therapeutic agents in bone-related diseases.World journal of orthopedics. 11/2012; 3(11):175-181. - [Show abstract] [Hide abstract]
ABSTRACT: Osteoclasts are generated from monocyte/macrophage-lineage precursors in response to colony-stimulating factor 1 (CSF-1) and receptor activator of nuclear factor-κB ligand (RANKL). CSF-1-mutated CSF-1(op/op) mice as well as RANKL(-/-) mice exhibit osteopetrosis (OP) caused by osteoclast deficiency. We previously identified RANKL receptor (RANK)/CSF-1 receptor (CSF-1R) double-positive cells as osteoclast precursors (OCPs), which existed in bone in RANKL(-/-) mice. Here we show that OCPs do not exist in bone but in spleen in CSF-1(op/op) mice, and spleen acts as their reservoir. IL-34, a newly discovered CSF-1R ligand, was highly expressed in vascular endothelial cells in spleen in CSF-1(op/op) mice. Vascular endothelial cells in bone also expressed IL-34, but its expression level was much lower than in spleen, suggesting a role of IL-34 in the splenic generation of OCPs. Splenectomy (SPX) blocked CSF-1-induced osteoclastogenesis in CSF-1(op/op) mice. Osteoclasts appeared in aged CSF-1(op/op) mice with up-regulation of IL-34 expression in spleen and bone. Splenectomy blocked the age-associated appearance of osteoclasts. The injection of 2-methylene-19-nor-(20S)-1α,25(OH)(2)D(3) (2MD), a potent analog of 1α,25-dihidroxyvitamin D(3), into CSF-1(op/op) mice induced both hypercalcemia and osteoclastogenesis. Administration of 2MD enhanced IL-34 expression not only in spleen but also in bone through a vitamin D receptor-mediated mechanism. Either splenectomy or siRNA-mediated knockdown of IL-34 suppressed 2MD-induced osteoclastogenesis. These results suggest that IL-34 plays a pivotal role in maintaining the splenic reservoir of OCPs, which are transferred to bone in response to diverse stimuli, in CSF-1(op/op) mice. The present study also suggests that the IL-34 gene in vascular endothelial cells is a unique target of vitamin D.Proceedings of the National Academy of Sciences 06/2012; 109(25):10006-11. · 9.81 Impact Factor
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Matsumoto Dental University
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Sioziri, Nagano, Japan
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Нагахама, Shiga, Japan
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Day in Engineering History Archive - June 8| Jan | Feb |
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from postage stamps from the country where the person or event occurred.June 8 1625: Gian Cassini, after whom the division between Saturn's A and B rings is named, was born. 1786: In New York City, commercial ice cream was manufactured for the first time. 1851: Jacques-Arsène d' Arsonval, who invented the reflecting moving-coil galvanometers used to measure weak electric currents, was born. 1920: Augusto Righi, who first showed that radio waves displayed characteristics of light wave behavior in the manner of reflection, refraction, polarization and interference, died. 1940: U.C. Berkeley researchers announced the creation of element 93, neptunium (Np). 1949: "1984," by George Orwell, was published. 1953: The first propane fuelled gas-turbine locomotive was placed in service by the Union Pacific Railroad. 1955: Tim Berners-Lee, inventor of the World Wide Web, was born. 1959: The first official U.S. missile mail was launched from the submarine USS Barbero at about 100 miles off the Atlantic Coast. 1979: The Source, the first computer public information service, went online. 1995: U.S. Air Force Capt. Scott O'Grady was rescued by U.S. Marines after being shot down over Bosnia.
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Words have changed my life in a profound way. Whether they were spoken, read, or written, they have carried a notable and consistent weight that has either reinforced the walls where the dark monsters of my heart reside, or they have slowly stripped them away. Truthfully, in the moment, I haven't decided which is worse. Tear down the walls, unleash, and face the monsters... I beg you to have patience with everything unresolved in your heart and try to love the questions themselves as if they were locked rooms or books written in a very foreign language. Don't search for the answers, which could not be given to you now, because you would not be able to live them. And the point is, to live everything. Live the questions now. Perhaps then, someday far in the future, you will gradually, without even noticing it, live your way into the answer.
— Rainer Maria Rilke, Letters to a Young Poet
Giving Birth Is Messy
It's safe to say that as we progress in life, giving birth to something new is messy and challenging. Just as any woman in labor would tell you, pushing through to the end might seem rather impossible at times.
I think, anyways.
I've always known that giving birth is messy. Whether it's a woman in labor, building a company from...
Read more
To each there comes, in their lifetime, a special moment when they are figuratively tapped on the shoulder and offered the chance to do a very special thing, unique to them and fitted to their talents. What a tragedy if that moment finds them unprepared or unqualified for that which could be their finest hour.
— Winston Churchill
"There's nothing like being thrown off a cliff to make you discover that you have wings."
Just Drown Already
A while back, God spoke three words to me that completely changed my life:
Just Drown Already.
I found myself in a place of constant chaos and confusion as I was trying to lose my life while simultaneously holding on to it. Like a square peg trying to fit in a round hole, it's never going to work.
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The Spartans opened the week by beating Oak Creek in a hard-fought 48-38 victory Nov. 27 at home, then suffered their first loss of the year Friday at Waukesha South, 45-43.
Against Oak Creek, East led 13-8 after one period and that 5-point margin was the biggest of any quarter. The Spartans expanded the lead to 24-17 at intermission and after a 10-10 third period, used a 14-11 fourth period to reach the final 10-point margin.
"The game was about tempo," coach Matt Malett said. "We want to go faster, and they wanted to play possession basketball. They defended well in the backcourt and they hurt us with offensive rebounds. They had four in the first half."
Senior captain Ryan McBride led the way with 14 points, followed by Jake Wiesmueller's 13, Jonathan McGinley's 11 and senior captain Mike Eberle's 10, the only four Spartans to score.
McBride nailed two 3-pointers, and McGinley added two baskets to lead the first quarter run. McBride then scored five of the 11 points in the second period to finish with 11 points at intermission, while McGinley had seven.
Eberle then scored five of East's 10 third-quarter points and Wiesmueller poured in seven of his team's 14 fourth-quarter points as the Spartans had excellent balance throughout the game.
"I am happy guys are stepping up," said Malett when asked about the balanced scoring. "With the injuries (Brian Smith, Mike Nowak), guys who usually stay in the background have stepped up. I'm happy with the point distribution."
In the heartbreaking loss at Waukesha South on Friday, the Spartans led 10-8 after one quarter and then played to an 11-11 tie in the second quarter.
After the Blackshirts came out, they doubled the score (16-8) in the third quarter to overcome a 21-19 half-time deficit.
Waukesha South trailed 21-12 in the second quarter, when the Blackshirts started to find their rhythm and went on a 7-0 run to end the first half and an 8-0 run to open the second half. Trent Prater, who had nine points on 3s, hit two of them in that stretch.
The Spartans were hurt at the free-throw line, sinking nine of 16, while the Blackshirts finished 16-of-25.
"We kept at it; for the most part we didn't panic," Malett said. "We could have done a couple things better. Look at the free throws, we want that reversed."
McBride continues to lead the Spartans, drilling in 19 points, which included six of seven from the free-throw line. McGinley also stepped up with 11 points, while Eberle added six. Tyree Pope led Waukesha South with 15 points.
"Being a senior, Ryan has put in a ton of hours in the summer," Malett said. "He shot a lot of jumpers in open gyms. He is starting to see it pay off with his increased range."
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'Axe Cop' Runs for President in FOX's Latest Animation Domination HD Short
by Kevin Fitzpatrick January 15, 2013 @ 5:30 PM
Prior to FOX's official announcement of its summer Animation Domination High Definition line-up, the first animated short of 'Axe Cop' not only previewed what lay in store for the absurdist comic series, but also revealed that 'Parks and Recreation' star Nick Offerman would lend his voice to the axe-wielding crime-fighter. Now, with its premiere set for Saturday, July 27, FOX has released yet another 'Axe Cop' short to promote the upcoming block. See 'Axe Cop' as the United States president inside!


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by Jack Sobon, Roger Schroeder Item # 5386
Format: Paperback
Pages: 208
Availability: Usually ships within 24 to 48 hours unless otherwise noted in the product description.
Whether you want to have a timber frame home built for you or want to build one yourself, here are all the basics of building with timbers. Co-authors, Jack Sobon and Roger Schroeder explain how to design for both strength and beauty and includes a starter project (a 12' x 16' toolshed) to develop your skills.
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Mother Earth News Fair Tickets > Fair Selected Titles


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Local Cop News: March 13, 2008Pennsylvania: Pittsburg officer kills suspect during struggle over gun Texas: Wounded DPD Officer Warned SWAT Training Lacking Florida: Sheriff's office suspends Taser-happy deputy New Jersey: SWAT probe costing Hoboken Ohio: Police Shooting Leaves Suspect Dead Chicago: Knife-wielding man died after being shot in abdomen, authorities say |
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Category Archives: Online Dating
Dating sites without registration
Dating without registration is a myth! Yes, of course, dating sites without registration exist. However, is it worth using them, if you really want real dates? I believe it isn't. Such popular dating sites as, for … Continue reading
ESET: love promotes penetrating of viruses on your computer
Specialists of ESET Company warn, that conspirators actively use the Valentine's Day for spreading viruses. Writers of viruses often use big informational reasons to increase spreading of virus programs and to increase their profit. Valentine's Day – holyday … Continue reading
Why don't men want to get married?
The majority of men reluctantly devotes their life to marriage. And although they never confess it, they really are afraid of legalizing officially their relationship with a woman. Women are very impatient in this question. They are almost certainly ready … Continue reading
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Women on dating sites
There are thousand women's profiles on dating sites. You need a lot of time to even cursorily see them all. All profiles contain typical questions and reading girl's answers, we can imagine an image of a girl, her demands which … Continue reading
Why do young girls choose married men?
Many girls encounter with such a thing: they experience feeling to married men. The most part of them experiences this moment of their life quietly and continues a normal life, get married and give birth to children. Another part drags … Continue reading
Why do we need new affairs?
Modern life doesn't give time to modern people for dating in real life. What to do, in order to find an interlocutor or a soul mate? Where to search for him or her? How to form an affair? What to … Continue reading
First date safety tips
I wrote about it, however, I have new thoughts and wanna share them with you. Ok. Let's get started. Some time later after your first messages you understand, that virtual communication is not enough, and it's time to date in … Continue reading
Reasons of disappointments of internet dating
It's difficult, probably, to find a person on our planet, who doesn't dream to find the only better half. And we all want to share him or her our sincere and ardent love, jointly cover the rest of our life … Continue reading
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The Next Iron Chef Caption It: Funny Business
by Maria Russo in Shows, November 18th, 2011In this week's episode of The Next Iron Chef: Super Chefs, the seven remaining rival chefs head to a comedy club to cook up some humor in the form of all-star dishes that are made with a heaping helping of improvisation.
In this sneak-peek shot, Saturday Night Live comedian Kevin Nealon stops by to help host and chef Alton Brown choose the ingredients the competitors must incorporate into their dishes. Will Kevin and Alton go easy on the chefs, giving them common ingredients, or will they select the oddest of the bunch?
Before you tune in this Sunday at 9pm/8c to watch these guys in action, we're challenging you, Next Iron Chef fans, to write your best captions (tastefully appropriate, please) for this moment in the comments below.
Who's your favorite rival chef so far? Cast your Fan Vote up to 10 times per day.
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ALTON: "I have a bone to pick with whoever suggested Don Pardo should take my place as the host of The Next Iron Chef…"
KEVIN (a.k.a. "Mr. Subliminal") mutters…"Kevin Brauch…"
Kevin: "This guy gives me an idea for a new show on the foodnetwork…the chef is a "cereal" killer…we could call it "Silence of the Lamb Chop"….Genius!!!!"
Ah!, Anne is out. all the chef that have a personality is gone, except one. after this show you know where the judges loyality stands. Zakarian please don't be too cocky. show some extreme techniques, so the audience knows and see it through there own eyes that you got the stuff.
The Pre-Challenge joke
Alton: "This week's challenge will start at a comedy club."
Beau: "and this being Next Iron Chef, funny business will not be tolerated." -
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