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Re: New Ticket - [IT !XSN-549809]: FW: Russia: Surkov's Busy Week
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I bought this dress, not because of necessity but because it was such a great price. On On the positive side, the material ifeels great against the skin, the workmanship is excellent and the print is quite nice. on the negative side, the sizing runs small so order one size up. I ordered the medium and the elastic around my waist was snug. didn't like the elasticized waist so I carefully removed it. It now looks like a comfortable sheath dress and I like the dress much better now.If the weather warms up, I may be able to wear this dress before the summer is officially over.

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Harleyville Things to Do
Early one fall, we visited the Beidler Forest from our son's place in Summerville. We visited the little information center and took a self-guided tour on the boardwalk which runs through the old growth forest over the black swamp water. It was cool, calm and peaceful in the forest. We saw a few birds and some turtles sunning on the logs as we followed the tour pamphlet.
For groups of ten or more, a guided tour is available. There are also canoe trips which let you paddle the deep blackwater of the swamp and meet alligators and cottonmouths on their turf! You can gain another perspective by taking one of the night walks.
* Admissions: $7; ages 6 to 18 $3.50; Audubon members $6
* Days and Holidays Closed: M, New Year's Eve/Day, Thanksgiving, Christmas Eve/Day
* Days and Hours of Operation: T-Su 9am-5pm and occasionally on MondayRelated to:- Family Travel
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... let him tell it, we don't stand a chance. Their offensive line is too good for us. Sean Taylor is the best thing that happened to football since they got rid of the leather helmets. Coles avgs 18.3 yds per catch so that's obviously 2 TDs by him alone. And lets not forget the most telling stat of all stats .... last year, they lost all their games by less than 7 points. Why are we even showing up?
I know that this isn't the right way to look at the game, but we are better at every position up and down the field. Quarterback, running back, offensive line, wide receiver, tight end, cornerback, safety, etc. Parcells has a historical edge over Gibbs. The game is at home. All signs point to blowout.
Their OL might be good but they are not good enough to beat our DL rotation. Yeah thats why Taylor got burned last year by a 7th round draft pick. Coles isn't even on the Redskins. Redskins lost three games by more than 7 points. They lost players on their defense this year so we will see tonight how good they are.
did Norm seriously say all that or are you just being sarcastic? thank you for heavily confusing people.
No, I'm making it all up. (The preceding was sarcasm). Yes, Norm said that and I'm sorry if "people" got confused. BTW: Coles was a slip up ... any die hard football fan knows that I meant Moss. Let's use are brains here people. Forgive a sportsbabe for not having an editor :laugh2:
No, I disagree. If Campo was the coach, then yes, but what game have the Cowboys lost that they were supposed to win, since Bill has been coach? That's his trademark, his teams beat the teams they are supposed to beat and play competitively with everyone else.


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The Mt. Washington Auto Road has partnered with a variety of lodging properties, so you and your family can have a nice place to stay before or after your trip up the Auto Road.
Category Archives: Car Clubs
Runners, Minis, and Sunrise – Oh My!
The weather turned out to be pretty exciting and beautiful for the majority of the weekend. However, it rained during most of the morning on Saturday, and just a few minutes before the cannon fired for the start of the … Continue reading
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Mini's On Top 2009
Well after many days of unending rain, it seemed inevitable that rain would too hinder the gorgeous sunset that hundreds of Mini Cooper owners travel to see each year at the annual Mini's On Top event. If you haven't caught … Continue reading


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Principal Suspended
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Tulsa, OK – The former principal at Houston Elementary in Tulsa is charged with contributing to the delinquency of a minor. 50-year-old Vicki Smith is accused of orchestrating a fight between two students in the hallway at the north side school.
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SUBSTITUTE TRUSTEE'S NOTICE OF SALE (Atkins)
WHEREAS, on October 31, 2003, CYNTHIA ATKINS, AN UNMARRIED WOMAN executed a Deed of Trust to CTC REAL ESTATE SERVICES as Trustee for the benefit of MORTGAGE ELECTRONIC REGISTRATION SYSTEMS, INC., AS A NOMINEE FOR COUNTRYWIDE HOME LOANS, INC., which Deed of Trust was filed on November 5, 2003 and recorded in Book 184 at Page 424 in the Office of the Chancery Clerk of Tunica County, Mississippi; and
WHEREAS, BAC HOME LOANS SERVICING, LP FKA COUNTRYWIDE HOME LOANS SERVICING LP, the current Beneficiary of said Deed of Trust, substituted RECONTRUST COMPANY, N.A. as Trustee therein, as authorized by the terms thereof, as evidenced by an instrument recorded in Book 235 at Page 77 in the Office of the Chancery Clerk of Tunica County, Mississipp! i; and
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text:
The Sweetwater Police Department (SPD) received 34 calls for service, issued one citation and made three arrests on Jan. 18, 2012.
The SPD received 20, 911 calls.
Calls for service:
ŌĆó Family violence assault ŌĆö 1100 block of Crane.
ŌĆó Theft ŌĆö┬Ā900 block of Circle Drive.
ŌĆó Theft ŌĆö┬Ā1300 block of James.
Arrested by SPD:
ŌĆó Jason Ben Anderton, 18 ŌĆö┬ĀFelony warrant.
ŌĆó┬ĀByron Blueford, 23 ŌĆö┬ĀCity warrant and county warrant.
ŌĆó┬ĀTracy Huddleston, 29 ŌĆö┬ĀDuty on striking an unattended vehicle.
The Nolan County Sheriff's Office (NCSO) had eight calls for service, served no civil papers and made three arrests on Jan. 18, 2012.
Arrested by NCSO:
ŌĆó Jeremy Enoch Harendt, 28, of Blackwell ŌĆö┬ĀWarrant/injury to a child/elderly/disable with intent of serious bodily harm.
ŌĆó┬ĀBilly Joe McKay, 28, of Sweetwater ŌĆö┬ĀWarrant/motion to revoke probation.
Arrested by DPS:
ŌĆó Johnny Lee Parker, 39, of Lubbock ŌĆö┬ĀRandall County warrants/aggravated theft by check and motion to proceed capias pro fine.
Calls for service:
ŌĆó Illegal dumping ŌĆö┬ĀCR 274/CR 152.
ŌĆó┬ĀReckless driver ŌĆö┬ĀI-20 MM 256 west bound.
ŌĆó┬ĀStray livestock ŌĆö┬ĀI-20 east of MM 247.
ŌĆó Prisoner transport ŌĆö┬ĀTaylor County.
ŌĆó Gas theft ŌĆö┬Ā12th Street, Roscoe.
ŌĆó Reckless driver ŌĆö┬ĀI-20 MM 242 west bound.
ŌĆó┬Ā911 open line ŌĆö┬ĀFM 1230.
ŌĆó┬ĀProwler ŌĆö┬ĀCedar Street, Roscoe.
Total in Custody: 45


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Day of Caring and GOLF! United Way Morning Show
The hard working and effervescent Darla Lindbjerg, executive director of Swift Current's United Way joined the Magic Morning Show on Monday.
She talked about the day of Caring, and put out notice that they wanted golfers for their classic June 14th.


text:
22 Comments
Realtime comments disabled
richloft 1695 days ago
Great photo!
Websissy63 1699 days ago
Your face has healed up well! Good luck in Lux!
Coolfire1982 1699 days ago
to avoid misunderstandings: this took place BEFORE the start of the race!
simpsonsports1 1700 days ago
loos like thi pic was taken super early.. wakey wakey lil big Lancey
Coolfire1982 1700 days ago
Hey larrybirdy and suzzi4u, then tell me why other riders just stopped and gave autographs?
clmimi 1700 days ago
I love the photo!!!
RikCelie 1701 days ago
Hey Lance, I can't wait seeing you win the Tour for the 8th. time. A Belgian Armstrong & Merckx fan
off2ride 1701 days ago
Lance, your face looks like it's pasted to the pic. Wut da.....
new_ortega 1701 days ago
Hey Lance, you look great! Go there and show them! Can't wait for TDF!
crzybiker 1701 days ago
Let me know if you'd like to set something up with the US AMB to the Netherlands when you're here
bibupoes 1701 days ago
I don't see any scars from the accident in TOC?
bluberi01 1701 days ago
what a nice picture :)
suzzi4u 1701 days ago
Sorry Coolfire, I'm with LarryBirdy. Lance would probably love to give everybody an autograph, but the man needs to keep moving...it's his job!
LarryBirdy 1701 days ago
Hey Coolfire, you should pick your opportunities better man. Running alongside someone is a big turnoff and it's hard signing with two hands on the bar, right? Chill.
TSang45 1701 days ago
Assume you 2 were discussing her ability to influence road paving projects - project smooth ride
BigBadBlue96 1701 days ago
It appears someone is bitter they didn't get an autograph!
atreidez 1701 days ago
Who's that 20 year old guy that looks like armstrong?
Coolfire1982 1701 days ago
unfortunately you ignored me completey when I asked you for an autograph.
Coolfire1982 1701 days ago
remember the fan today at the start who ran by your side in the yellow shirt? this was me!
Coolfire1982 1701 days ago
would be nice, if you showed this enthusiasm to your fans...


text:
Comment: Re:"Computer" failure? (Score 1) 68
Comment: Re:Even I bought a PS1 and PS4 (Score 1) 101
I generally hate any game products from Japanese countries, since they're such nationalistic/xenophobic and conformist society (Japan always gets all the releases first, every game is on-rails with the same lame anime style, and so on).
I think there's irony somewhere in there. Or sarcasm. Or worse.
Comment: Re:510kph is airliner speed? (Score 4, Informative) 419
Comment: Re:FreeBSD (Score 1, Insightful) 123
Comment: Re:FreeBSD (Score 1) 123
FreeBSD was there first.
Lol, no. You're comparing the version of a kernel (Linux) with a distribution or flavour (FreeBSD). Slackware Linux 1.0 was released July 17th, 1993. Yggdrasil Linux was released in 1992.
Comment: Re:And so therefor it follows and I quote (Score 2) 353
Really? So you mean I can legally download it from Apple and install it on a VM or PC? Download link?
It's free as in beer. You have it for free when you buy an Apple product, while OEMs actually buy Windows licences, that's the point. Microsoft cannot say that it's free, since they get money from the OEMs, Apple can. It's not hard to understand.


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Mercury Public Affairs has hired Adam Keigwin as senior vice president. He most recently served as chief of staff to Sen. Leland Yee of San Francisco. During his 10 years in the Capitol, Keigwin directed the Senator's public relations and communications as well as managed his political and legislative agenda.
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Russell Wilson Texas jersey on sale Sunday
Richard DurrettSURPRISE, Ariz. -- The Texas Rangers will be selling Russell Wilson merchandise just in time for the Super Bowl-winning quarterback's arrival at spring training next week and includes home white and royal replica jerseys and a "Seahawk Green" T-shirt...
Blog | February 28, 2014 -
Ticket plan for Monday's play-in game
Richard DurrettARLINGTON, Texas -- The Texas Rangers face the Tampa Bay Rays on Monday at 7:07 p.m. CT in the tiebreaker game to determine who gets to face Cleveland in Wednesday's AL wild-card game. Some information on tickets: • Tickets on sale now. Fans...
Blog | September 29, 2013 -
Trade targets: Chris Sale, Jake Peavy
Richard DurrettWith less than two weeks until MLB's trade deadline, we'll take a look in the coming days and weeks at some names that could be available between now and the deadline, then debate whether those names make sense for the Texas Rangers. Today's trade...
Blog | July 16, 2013 -
Rangers 20-game ticket plans on sale now
Richard DurrettThe Texas Rangers have 20-game ticket plans for the 2013 season on sale now. Here are some details: Fans can choose from three 20-Game Plan schedules or can select their own games with a Fan's Choice 20. The 20-Game Plans are available in nine sea...
Blog | November 27, 2012 -
Rangers to play Padres at Alamodome
Richard DurrettThe Texas Rangers announced Friday that they will play two exhibition games -- Friday, March 29 at 7:05 and Saturday, March 30 at 1:05 p.m. -- against the San Diego Padres at the Alamodome in San Antonio. Tickets go on sale to the general public at ...
Blog | November 16, 2012 -
Fan Fest tickets go on sale Thursday
Richard DurrettThe Texas Rangers announced today that tickets for the club's annual Fan Fest, held Jan. 11-12 at the Arlington Convention Center, will go on sale Thursday. You can go to the club's website or call 972-RANGERS. Admission is $25 for adults and $15 ...
Blog | November 14, 2012 -
AL wild-card game tickets now on sale
Richard DurrettFans interested in going to Friday's AL wild-card game between the Texas Rangers and Baltimore Orioles at Rangers Ballpark in Arlington can purchase tickets online at texasrangers.com/postseason or at the West Box Office at the stadium (open until 6 ...
Blog | October 04, 2012 -
Fewer than 100 tickets left for Opening Day
Richard DurrettSURPRISE, Ariz. -- Saturday was the first day for 2012 individual ticket sales and the Texas Rangers sold more than 100,000 tickets as of 4 p.m. CT. While less than 100 obstructed view and standing-room only tickets remain for Opening Day, you ca...
Blog | March 03, 2012 -
Club announces ticket specials, promotions
Richard DurrettSURPRISE, Ariz. -- The Rangers on Wednesday announced some ticket specials and promotion games for the 2012 season. Tickets for all 2012 home games go on sale Saturday at 9 a.m. at Rangers Ballpark in Arlington, texasrangers.com or by calling 972-...
Blog | February 29, 2012 -
Old bleacher seats for sale from Ballpark
Richard DurrettThe Texas Rangers are selling the old bleacher seats from Rangers Ballpark in Arlington, which won't be used now that the outfield area is being renovated and regular seats are being installed. The bleacher seats are $540 (includes tax) and were o...
Blog | February 10, 2012 -
Tickets for Cubs-Rangers in Las Vegas go on sale Monday
Richard DurrettTickets for the Rangers-Cubs series in Las Vegas on Saturday and Sunday, March 17-18, go on sale Monday, Feb. 13 at 2 p.m. central time. You can purchase tickets at the Cashman Field box office or through Ticketmaster at www.ticketmaster.com or 1-800...
Blog | February 08, 2012 -
Yu Darvish is Texas Rangers' gateway to Japan business
Richard DurrettThe Rangers will have chances to cash in on Yu Darvish's popularity in Japan.
Story | Conversation | January 25, 2012 -
Rangers announce 2012 FanFest details
Richard DurrettThis year's Texas Rangers Dr Pepper Awards Show and FanFest will take place Jan. 12-15 at the Arlington Convention Center. Tickets for both events go on sale Thursday (tomorrow) Dec. 1 at 9 a.m. at texasrangers.com and at 972-RANGERS. The club's rele...
Blog | November 30, 2011 -
Limited ALCS seats on sale 9 a.m. Saturday
Richard DurrettOAKLAND, Calif. -- The Rangers announced Wednesday that a limited number of reserved seats, obstructed view and standing room only tickets for possible ALCS games at Rangers Ballpark in Arlington will be on sale to the public starting at 9 a.m. Satur...
Blog | September 22, 2011 -
Josh Hamilton jersey 7th most popular
Richard DurrettSURPRISE, Ariz. -- The MLBPA released the most popular jersey sales for the 2010 calendar year. The top Ranger on the list was Josh Hamilton, at No. 7. Ian Kinsler was No. 17. Cliff Lee was No. 5 and his ranking reflects all three teams he was with i...
Blog | March 23, 2011 -
Ticket sales up 15 percent on first day
Richard DurrettSURPRISE, Ariz. -- The Rangers sold more than 108,000 tickets on Saturday, the first day of individual game tickets. That's an increase of 15 percent over 2010 and includes sales via web, phone and the ballpark. The number represents singles and grou...
Blog | March 05, 2011


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March 12, 2013
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SPI: The Plastics Industry Trade Association
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Brennan Georgianni
Hosted by: Michael Taylor of SPI, Paul Blanchard of IHS and Ana Gamboa of IHS
This is the second in a series of quarterly webinars hosted by SPI and presented by IHS (formerly CMAI) experts exclusively for our members. These webinars will represent customized reports centered around a portfolio of information on the global polymers markets. The objective of these offerings is to provide SPI and its membership with a significant amount of insight into the market dynamics for polymers of interest. A longer term goal is to develop an understanding of the plastics supply chain. This second webinar will focus on PBT, PC, ABS and PVC.
This special report newly released by PN and sponsored by The Conair Group examines current trends in the use of plastics in automotive, materials innovations and the changing landscape. It includes a review of legislative/regulatory activity impacting vehicle development and lightweighting, market opportunities & challenges for mold and toolmakers, innovative design strategies being implemented by major OEMs and suppliers, as well as a review of key indicators in Canada, Mexico, Brazil and China.
Learn moreThis report is a review and analysis of the North American Plastics Recycling Industry, including key trends and statistics based on 2013 performance. We examine market environment factors, regulatory issues, industry challenges, key drivers and emerging trends in post-consumer and post-industrial recycling.
Learn more
Plastics News BUNDLED package contains our in-depth Market Analysis of the Injection Molding segment. You will gain keen insight on current trends and our economic outlook.
As a BONUS this includes PN's updated 2014 database of North American Injection Molders RANKED by sales volume. Sort, merge, mail & prospect by end market, materials processed, region, # of plants and more.
January 27, 2015 - January 29, 2015AMI's Thermoplastic Concentrates 2015
January 28, 2015 - January 30, 2015BioPlastics: Re-Invention of Plastics via Renewable Chemicals
January 27, 2015 - January 29, 2015SPI: Fluoropolymers Division 2015 Meeting
January 26, 2015 - January 29, 2015Sprayfoam 2015 Convention & Expo
January 29, 2015 - January 29, 2015Decernis Portal Re-Launch for FDCPMC Webinar
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Reviewed Cucumber Salad
Jun 15, 2012 in Food Network Community Toolbox on FoodNetwork.com
"OMG!!!!!! Just like my (german) Grandma Schulte used to make. Absolutely loved it! Only changes: left out the dill (not a fan), used sweet&low (cuz I didn't have sugar) and made sure to sweat the cucumber before mixing. LOVE, LOVE, LOVE IT!! I feel like I finally found her recipe!""


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You are here: home » archives » February, 2012
Welcome to Georgia Tech Wreck Racing club. We hope you enjoy your stay!
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Check out our trip back from the Engineer's Week Fair on campus to the shop. Thanks GTPD for the help.
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News Details
Horner: 'Mercedes favourites'
Red Bull boss Christian Horner has described Mercedes are the new favourites to win the 2014 F1 Constructors' Championship with the reigning World Champions suffering yet another fresh setback with the RB10 on Friday in Bahrain.After four successive World Championship doubles, Red Bull have endured a nightmare winter at the start of F1's new turbo era and completed just 28 laps on Day Three of the second test due to 'a mechanical issue that we hadn't encountered before'.
Although Daniel Ricciardo insisted afterwards that the team are "heading in the right direction," the RB10 has barely been seen on track since being unveiled at Jerez three weeks ago.
While Mercedes have enjoyed...
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St Etienne's London Soundtrack Is Good But Needs Movie
Get a taste of London's post-war past.
Get a taste of London's post-war past.
So much more than Downton.
This IS the event you're looking for.
Clare Stewart gives us the inside track.
Over 200 films to choose from in the capital.
And not a street dancer in sight.
Promising mix of movies returns.
Year-long retrospective.
Flash Gordon, The Day the Earth Caught Fire and The Man Who Fell ...
Five months of Chinese cinema begin in June.
Film, Super8 and VHS artists on the early 80s.
BFI's third Made In Britain season celebrates the independent producer.
Rare opportunity for Studio Ghibli fans to view its entire output.
Annual LGBT film festival, newly labelled.
Celebrating one of Hollywood's greatest actors..


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We recently stayed at the Haber Motel in Estes Park. Upon arrival we noticed the very lack of parking available - there are the exact number of spaces as there are rooms. We entered the office and were not greeted by the man, who I assume to be the owner of the property. Instead, we had to say Hi to... More
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Priceline and Odigeo so you can book your The Haber Motel reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


text: Athletics Video: Centenarian sets marathon record Add to ... The Globe and Mail Published Sunday, Oct. 16 2011, 9:50 PM EDT Last updated Sunday, Feb. 24 2013, 11:39 AM EST Fauja Singh has secured a spot in the Guinness World Records after completing the Scotiabank Toronto Waterfront Marathon at the age of 100, becoming the oldest person to ever finish a fill-distance marathon. Watch More Video: Super Bowl host city reeling over sports deals After a century of quiet ice, curling has returned to Brooklyn Kobe Bryant out for nine months after shoulder surgery The wild side of Super Bowl media day Excitement builds at Super Bowl media day Drought in Brazil spurs worries over Rio 2016 water events Son calls Gordie Howe's recovery progress a 'miracle' Just how does that yellow first down line work? Gary Bettman announces World Cup of Hockey comeback in 2016 Belichick on 'deflate-gate': We didn't cheat NHL player injuries provide chance for rookies at all-star game Cubs Hall of Famer Ernie Banks dies at 83 Patriots players express support for Tom Brady Former NFL QB explains deflated footballs Jeff Gordon says 2015 NASCAR season his last Tom Brady on 'deflate-gate': I didn't alter the ball in any way Don Cherry: Connor McDavid has had 'magic' for years Connor McDavid faces teammate at top prospects game NHL players excited for All-Star weekend Max Scherzer, Nationals agree to $210-million deal Comments AA


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Publications (11)72.34 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: The reaction of macromolecules such as enzymes and antibodies with cell surfaces is often an inefficient process, requiring large amounts of expensive reagent. Here we report a general method based on macromolecular crowding with a range of neutral polymers to enhance such reactions, using red blood cells (RBCs) as a model system. Rates of conversion of type A and B red blood cells to universal O type by removal of antigenic carbohydrates with selective glycosidases are increased up to 400-fold in the presence of crowders. Similar enhancements are seen for antibody binding. We further explore the factors underlying these enhancements using confocal microscopy and fluorescent recovery after bleaching (FRAP) techniques with various fluorescent protein fusion partners. Increased cell-surface concentration due to volume exclusion, along with two-dimensionally confined diffusion of enzymes close to the cell surface, appear to be the major contributing factors.Nature Communications 01/2014; 5:4683. · 10.74 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Patients requiring chronic red blood cell (RBC) transfusions for inherited or acquired anemias are at risk of developing transfusional iron overload, which may impact negatively on organ function and survival. Current iron chelators are suboptimal due to inconvenient mode of administration and/or side effects. Herein, we report a strategy to engineer low molecular weight iron chelators with long circulation lifetime for the removal of excess iron in vivo using a multifunctional dendritic nano-polymer scaffold. Desferoxamine (DFO) was conjugated to hyperbranched polyglycerol (HPG) and the plasma half life (t1/2) in mice is defined by the structural features of the scaffold. There was a 484 fold increase in t1/2 between the DFO (5 min) versus the HPG-DFO (44 hrs). In an iron overloaded mouse model, efficient iron excretion by HPG-DFO in the urine and feces was demonstrated (p = 0.0002 and 0.003 respectively) as was a reduction in liver, heart, kidney and pancreas iron content, and plasma ferritin level (p= 0.003, 0.001, 0.001, 0.001 and 0.003, respectively) compared to DFO. Conjugates showed no apparent toxicity in several analyses including body weight, serum lactate dehydrogenase level, necropsy analysis and by histopathological examination of organs. These findings were supported by in vitro biocompatibility analyses, including blood coagulation, platelet activation, complement activation, red blood cell aggregation, hemolysis, and cell viability. This nano-polymer based chelating system would potentially benefit patients suffering from transfusional iron overload.ACS Nano 11/2013; 7(12):10704-10716. · 12.03 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Modulation of cell surface properties via functional modification is of great interest in cell-based therapies, drug delivery, and in transfusion. We study the in vivo circulation, immuogenicity, and mechanism of clearance of hyperbranched polyglycerol (HPG)-modified red blood cells (RBCs) as a function of molecular properties of HPGs. The circulation half-life of modified cells can be modulated by controlling the polymer graft concentration on RBCs; low graft concentrations (0.25 and 0.5 mM) showed normal circulation as that of control RBCs. Molecular weight of HPG did not affect the circulation of modified RBCs. HPG grafting on RBCs reduced CD47 self-protein accessibility in a graft concentration-dependent fashion. HPG-grafted RBCs are not immunogenic, as is evident from their similar circulation profile upon repeated administration in mice and monitoring over 100 days. Histological examination of the spleen, liver, and kidneys of the mice injected with modified RBCs revealed distinct differences, such as elevated iron deposits and an increase in the number of CD45 expressing cells at high graft concentration of HPGs (1.5 mM); no changes were seen at low graft concentration. The absence of iron deposits in the white pulp region of the spleen and its presence in the red pulp region indicates that the clearance of functional RBCs occurs in the venous sinuses mechanical filtering system, similar to the clearance of unmodified senescent RBCs. HPG modification at grafting concentrations that yield long circulation in mice produced camouflage of a large number of minor blood group antigens on human RBCs, demonstrating its utility in chronic transfusion. The normal circulation, nonimmunogenic nature, and the potential to modulate the circulation time of modified cells without toxicity make this HPG-based cell surface modification approach attractive for drug delivery and other cell-based therapies.Biomacromolecules 05/2013; · 5.79 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Red blood cell (RBC) transfusion is vital for the treatment of a number of acute and chronic medical problems such as thalassemia major and sickle cell anemia (1-3). Due to the presence of multitude of antigens on the RBC surface (~308 known antigens (4)), patients in the chronic blood transfusion therapy develop alloantibodies due to the miss match of minor antigens on transfused RBCs (4, 5). Grafting of hydrophilic polymers such as polyethylene glycol (PEG) and hyperbranched polyglycerol (HPG) forms an exclusion layer on RBC membrane that prevents the interaction of antibodies with surface antigens without affecting the passage of small molecules such as oxygen ,glucose, and ions(3). At present no method is available for the generation of universal red blood donor cells in part because of the daunting challenge presented by the presence of large number of antigens (protein and carbohydrate based) on the RBC surface and the development of such methods will significantly improve transfusion safety, and dramatically improve the availability and use of RBCs. In this report, the experiments that are used to develop antigen protected functional RBCs by the membrane grafting of HPG and their characterization are presented. HPGs are highly biocompatible compact polymers (6, 7), and are expected to be located within the cell glycocalyx that surrounds the lipid membrane (8, 9) and mask RBC surface antigens(10, 11).Journal of Visualized Experiments 01/2013; - [Show abstract] [Hide abstract]
ABSTRACT: Hyperbranched polyglycerol (HPG) and polyethylene glycol (PEG) polymers with similar hydrodynamic sizes in solution were grafted to red blood cells (RBCs) to investigate the impact of polymer architecture on the cell structure and function. The hydrodynamic sizes of polymers were calculated from the diffusion coefficients measured by pulsed field gradient NMR. The hydration of the HPG and PEG was determined by differential scanning calorimetry analyses. RBCs grafted with linear PEG had different properties compared to the compact HPG grafted RBCs. HPG grafted RBCs showed much higher electrophoretic mobility values than PEG grafted RBCs at similar grafting concentrations and hydrodynamic sizes indicating differences in the structure of the polymer exclusion layer on the cell surface. PEG grafting impacted the deformation properties of the membrane to a greater degree than HPG. The complement mediated lysis of the grafted RBCs was dependent on the type of polymer, grafting concentration and molecular size of grafted chains. At higher molecular weights and graft concentrations both HPG and PEG triggered complement activation. The magnitude of activation was higher with HPG possibly due to the presence of many hydroxyl groups per molecule. HPG grafted RBCs showed significantly higher levels of CD47 self-protein accessibility than PEG grafted RBCs at all grafting concentrations and molecular sizes. PEG grafted polymers provided, in general, a better shielding and protection to ABO and minor antigens from antibody recognition than HPG polymers, however, the compact HPGs provided greater protection of certain antigens on the RBC surface. Our data showed that HPG 20 kDa and HPG 60 kDa grafted RBCs exhibited properties that are more comparable to the native RBC than PEG 5 kDa and PEG 10 kDa grafted RBCs of comparable hydrodynamic sizes. The study shows that small compact polymers such as HPG 20 kDa have a greater potential in the generation of functional RBC for therapeutic delivery applications. The intermediate sized polymers (PEG or HPG) which showed greater antigen camouflage at lower grafting concentrations have significant potential in transfusion as universal red blood donor cells.Biomaterials 07/2012; 33(31):7871-83. · 8.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The in vivo circulation of hyperbranched polyglycerol (HPG) grafted red blood cells (RBCs) was investigated in mice. The number of HPG molecules grafted per RBC was measured using tritium labeled HPGs ((3)H-HPG) of different molecular weights; the values ranged from 1 × 10(5) to 2 × 10(6) molecules per RBC. HPG-grafted RBCs were characterized in vitro by measuring the electrophoretic mobility, complement mediated lysis, and osmotic fragility. Our results show that RBCs grafted with 1.5 × 10(5) HPG molecules per RBC having molecular weights 20 and 60 kDa have similar characteristics as that of control RBCs. The in vivo circulation of HPG-grafted RBCs was measured by a tail vain injection of (3)H-HPG60K-RBC in mice. The radioactivity of isolated RBCs, whole blood, plasma, different organs, urine and feces was evaluated at different time intervals. The portion of (3)H-HPG60K-RBC that survived the first day in mice (52%) remained in circulation for 50 days. Minimal accumulation radioactivity in organs other than liver and spleen was observed suggesting the normal clearance mechanism of modified RBCs. Animals gained normal weights and no abnormalities observed in necropsy analysis. The stability of the ester-amide linker between the RBC and HPG was evaluated by comparing the clearance rate of (3)H-HPG60K-RBC and PKH-26 lipid fluorescent membrane marker labeled HPG60K-RBCs. HPG modified RBCs combine the many advantages of a dendritic polymer and RBCs, and hold great promise in systemic drug delivery and other applications of functional RBC.Biomaterials 04/2012; 33(10):3047-57. · 8.31 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The covalent attachment of hydrophilic polymers or biopharmaceuticals to the surface of red blood cells (RBCs) has previously been shown as a relatively compatible and effective method for a range of applications. Here, the first example of cell-surface grafting with a hyperbranched and multi-functional macromolecule is described. A range (3 kDa-101 kDa) of dense, globular, and blood compatible hyperbranched polyglycerols (HPG) were synthesized and functionalized with cell-surface reactive, succinimidyl succinate groups (1-12 groups per polymer). Subsequently, HPG was grafted to the RBCs, which were analyzed using physical characterization techniques such as aqueous two-phase partitioning and particle electrophoresis. It was found that the extent of grafting was enhanced by increasing HPG molecular weight, the number of reactive groups per HPG, HPG concentration, and reaction time. Good in vitro cell viability - as measured by lipid peroxidation, hemoglobin oxidation, cell lysis, osmotic fragility, stability in fresh serum and aggregation behavior - was observed for grafting concentrations up to 4.8 mm. The multi-functional aspect of HPG is highlighted by the following observations: using fluorescein-labeled Anti-D (monoclonal) antibody and flow cytometry, the detection of cell-surface Rhesus (RhD) antigens were significantly reduced upon HPG grafting. Secondly, the potential for using HPG as a multi-functional, delivery agent was demonstrated by attaching fluorescent markers to the HPG via degradable linkages prior to grafting.Biomaterials 02/2010; 31(14):4167-78. · 8.31 Impact Factor -
Article: Enhanced cell surface polymer grafting in concentrated and nonreactive aqueous polymer solutions.
[Show abstract] [Hide abstract]
ABSTRACT: Macromolecular cell surface modification techniques have shown tremendous utility in various biomedical applications. However, a major drawback concerns inefficient cell surface modification caused by the poor association of hydrophilic macromolecules with cell surfaces. Here, a novel, highly efficient, and universal strategy in which nonreactive "additive" macromolecules are used to modulate the grafting efficiency of cell surface reactive, hydrophilic macromolecules is described. Unprecedented enhanced cell surface modifications by up to 10-fold were observed when various concentrations of a suitable "additive" polymer was present with a constant and low concentration of a "reactive" macromolecule. The importance of this increased efficiency and the possible mechanisms involved are discussed. The cell compatible technique is demonstrated in the case of four different cell types--red blood cells (RBC), leukocytes, platelets, and Jurkat cells. A practical application of grafting macromolecules to cell surfaces in concentrated polymer solutions is demonstrated by the enhanced camouflage of RBC surface antigens for the development of RhD null RBC. In principle, the technique can be adapted to various macromolecular systems and cell types, with significant potential for biomedical applications such as live cell based technologies.Journal of the American Chemical Society 02/2010; 132(10):3423-30. · 11.44 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Conventional antithrombotic drug discovery requires testing of large numbers of drug candidates. We used computer-aided macromolecular interaction assessment (MIAX) to select antithrombotic molecules that mimic and therefore block platelet GPIb's binding to von Willebrand factor (vWf), an early step in thrombus formation. We screened a random array of 15-mer D-amino acid peptides for binding vWf. Structures of 4 candidate peptides were inferred by comparison to sequences in protein databases, conversion from the L to D conformations and molecular dynamics (MD) determinations of those most energetically stable. By MIAX, we deduced the amino acids and intermolecular hydrogen bonds contributing to the GPIb-vWf interaction interface. We docked the peptides onto vWf in silico to localize their binding sites and consequent potential for preventing GPIb-vWf binding. In vitro inhibition of ristocetin-initiated platelet agglutination confirmed peptide function and suitability for antithrombotic development, thereby validating this novel approach to drug discovery.Journal of Molecular Modeling 11/2008; 14(12):1191-202. · 1.87 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: RGD (arginine-glycine-aspartic acid) is a known peptide sequence that binds platelet integrin GPIIbIIIa and disrupts platelet-fibrinogen binding and platelet cross-linking during thrombosis. RGD peptides are unsuitable for clinical applications due to their high 50% inhibitory concentration (IC50) and low in vivo residence times. We addressed these issues by conjugating RGD peptides to biocompatible macromolecular carriers: hyperbranched polyglycerols (HPG) via divinyl sulfone. The GPIIbIIIa binding activity of RGD was maintained after conjugation and the effectiveness of the HPG-RGD conjugate was dependent upon molecular weight and the number of RGD peptides attached to each HPG molecule. These polyvalent inhibitors of platelet aggregation decreased the IC50 of RGD in an inverse linear manner based on the number of RGD peptides per HPG. Since HPG-RGD conjugates do not cause platelet activation by degranulation and certain substitution ratios do not increase fibrinogen binding to resting platelets, HPG-RGD may serve as a model for a novel class of antithrombotics.Bioconjugate Chemistry 07/2008; 19(6):1241-7. · 4.82 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: To clarify the interactions of liposomes with blood cells, this study examined the behaviour of liposomes of a range of compositions in the presence of purified human blood cells in buffer or plasma; or in whole blood, or in mice in vivo. Liposomes, labeled with the hydrophilic fluorochrome, carboxy fluorescein (CF), or with membrane-sequestering R18 or FITC-labeled phospholipids, were mixed with blood cells and the appearance of the fluorochromes in the blood cell population was monitored by flow cytometry. Irrespective of composition, with or without poly(ethylene glycol), all types of liposomes were found to interact rapidly and dose-dependently with red cells, leukocytes and platelets, both in vitro and in vivo. This took place equally in the presence and the absence of plasma proteins and functional enzyme cascades, suggesting that the prime facie interaction is opsonization-independent and is consistent with liposome-blood cell fusion.Artificial Cells Blood Substitutes and Biotechnology 12/2003; 31(4):395-424. · 0.71 Impact Factor
Publication Stats
69 | Citations | |
72.34 | Total Impact Points | |
Top Journals
Life Science Research Center
Halifax, Nova Scotia, Canada
University of British Columbia - Vancouver
- • Centre for Blood Research (CBR)
- • Department of Pathology and Laboratory Medicine
Vancouver, British Columbia, Canada
Société canadienne du sang
Ottawa, Ontario, Canada


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NPR Cities: Urban Life In The 21st Century
City Life Snapshot: Music In Austin, Texas
A different take on city as melting pot now, in this City Life Snapshot from Austin, Texas.
BALDOMERO FRANK ALVAREZ CUELLAR: I'm Baldomero Frank Alvarez Cuellar, and that's a mouthful. And I am one-half of the owners of Rancho Alegre Radio.
BLOCK: Back in the '70s and '80s, Conjunto music was everywhere in Austin, and Alvarez is trying to bring it back.
CUELLAR: We brought in bands that people hadn't seen here in years. One of them was Rene Joslin, who had to retire due to illness. He hadn't played in like 14 or 15 years.
CUELLAR: We were expecting a little rust and the man blew everybody away.
CUELLAR: With the Conjunto, you'll have the bass, the drums, the accordion. You'll have the vocals and the backup vocals, that's it.
RENE JOSLIN: (Singing in foreign language)
CUELLAR: Conjunto music comes from European, German influences, especially after World War II. And, you know, it's influenced by everything Spanish, Mariachi, and everything accordion which is far as Polish to Czech to German influences, polkas, and it all meshed. Because I know nowadays people think of migrant workers as being Mexican but back in the day, you know, from the stories that my father would tell me, if you were a foreigner you were a migrant worker.
CUELLAR: My family came from migrant workers. We picked everything from oranges, cherries, cucumbers. Back in the day, Conjuntos were the only ones who were coming to the fields to play. And dances were - we moved furniture out from a house for one night, and everyone did it.
JOSLIN: (Singing in foreign language)
CUELLAR: I'm not sure who coined it first, Conjunto, but it was the nightly gathering to mellow out - maybe have a beer or a drink of whisky or something and forget the woes from the next day's job. This will get you ready for the next week, no matter how hard you've had it.
Thanks to Delaney Hall at KUT in Austin for that City Life Snapshot. Delaney is part of Localore, that's a national initiative from the Association of Independence in Radio. Transcript provided by NPR, Copyright National Public Radio.


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My search has led to the Poplar Bluff Forum re: CUNNINGHAM/RUTLAND descendants of John LANCE and Arthula PHILLIPS. My understanding is that a Myrtle Rutland has been a gift to the community of Poplar Bluff, Missouri. I would like to make contact with a member of this family regarding a question of our ancestor James Lance of Franklin County, Illinois. Notify Administrator about this message?
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Leaders from various sectors called on the public to remain committed to the peace process amidst recent challenges, especially the tragedy in Mamasapano, Maguindanao, last January 25, which claimed nearly 50 lives.
The Philippines is a republic with a presidential form of government wherein power is equally divided among its three branches: executive, legislative, and judicial.
The three branches:


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Event Name
- OR - Select an option belowSome of the city's best steaks -- dry-aged Angus Charlet -- are grilled at Luke's, and all of them swim in owner Mike Lucas's signature slick of olive oil, garlic salt and oregano. The meat comes with a bowl of salad for the table and a huge side of starch; go for the oily pan-fried potatoes with onions. Kids under twelve eat spaghetti for free.


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Physical and speedy Darton (Ga.) College powered its way to a 2-0 win over Chandler-Gilbert Community College in the semifinals of the National Junior College Athletic Association Division I women's soccer championship hosted by CGCC on Friday.
Fifth-seeded CGCC (20-2-1) will attempt to finish third when it plays North Idaho at noon Sunday. Darton will play Lewis and Clark (Ore.) College at 2:30 p.m. Sunday for the championship.
"We worked hard, we had some opportunities midway in the second half, we made some adjustments, we hit the cross bar a couple of times, the ball just did not fall our way," said CGCC coach Jonathan Berzins.
The Coyotes came out strong with four shots on goal in the first half, but late in the half, top-seeded Darton (23-0-1) turned on its speed and went on the attack, resulting in a goal from Darton's JoAnn Saliba at 41:16.
Just two minutes into the second half, Darton's Stephanie Daniels ended up with a clear path to the goal to put the Cavaliers in control.
CGCC stayed in the fight and had a couple of opportunities, including a shot from Kayla Poe that bounced off the goal post with 10 minutes left in the contest.
Despite the loss, Berzins said he couldn't be more pleased.
"We had a great fan base this week," Berzins said. "We definitely had firsts for our school, winning our district, winning our region, making it to nationals, being in the top four in the country. I look forward to bigger and better things."
Berzins said he already has "about seven or eight kids" committed to play next year from various East Valley high schools.


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Stayed on 2 seperate occasions in September, I called to make my reservation and in all the times I have stayed here there has never been a mistake with my reservation. The hotel is not on the main drag but it is quiet and clean. \pleasant staff and free popcorn in the afternoon/evening.
The beakfast consists of coffe / juice/ and cereal and oast and coffee. \nothing fancy but the price of the room reflects this. \i have always had a decent bed and fresh linnens and towels. Also this hotel is adjacent to the hospital and helipad. So trauma patients are brought there, be glad it is ot you when u hear the chopper. and it does not go on all night!!. Very reasonable prices and quiet hotel. True no onsite pool or restaurant but if you got there it was probably by car so hop in it and drive to one of the many restaurants in the area.
- Official Description (provided by the hotel):
- Clean, Quiet, FriendlySituated Next to Benefis Healthcare and Great Falls ClinicClose to Shopping, Restaurants and EntertainmentComplimentary Continental BreakfastFree WiFiFitness Center24-Hour StaffingGuest Laundromat Valet Laundry ServiceEnjoy Our Cravens CoffeeOperable Windows, Individual HVACIn-Room Coffee, Hair Dryer, Iron & BoardReclinersConference Room ElevatorMicrowaves, Fridges AvailablePet Friendly AAA Approved ADA - Compliant Rooms AvailableFree Fresh Popcorn Every Evening ... more less
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- TripAdvisor is proud to partner with Hotels.com, Expedia, Booking.com, Travelocity, Orbitz, Cheap Tickets, Despegar.com and Odigeo so you can book your Great Falls Inn by Riversage reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Great Falls Hotel


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17" Compact Beverage Cooler with 2.5 cu. ft. Capacity, Double Pane Tempered Glass Door, Automatic Defrost, Factory Installed Lock, Interior LED Lighting and Commercial Use Approved
Our Price
30" Built-in Dual-Zone Beverage Center with 66-Bottle Capacity, Adjustable Wooden Shelves, LED Lighting, Digital Thermostats and Factory Installed Locks
24" Built-In Beverage Center with 6 Bottle Capacity, 126 Beverage Can Capacity, 3 Adjustable Tempered Glass Shelves, Digital LED Thermostat and Audible Alarm Alerts
24" Built-In French-Door Beverage Center with 61 Beverage Can Capacity, 21 Wine Bottle Capacity, 3 Adjustable Tempered Glass Shelves, 5 Full-Extension Wine Racks, Audible Alarm Alerts and Dual Temperature Zones
24" Built-in Beverage Center with 2 Cantilevered Glass Shelves, Automatic Defrost, Dynamic Cooling Technology, Integrated Door Lock, Interior LED Lighting and ADA Compliant
24" Beverage Center with 65 Can Capacity, 16 Wine Bottle Capacity, Dual Cooling Zones, 2 Beech-Trimmed Wine Racks, 2 Glass Shelves and Glass Door: Stainless Steel, Right-Hand Hinge with Door Lock
24" Undercounter Side by Side Dual Zone Wine/Beverage Cooler with 19 Wine Bottles Capacity, LED Lighting, Security Lock, Auto-Lock Controls and Electronic Controls
24" Built-in Refrigerator with 2 Cantilever Glass Shelves, 1 Glide-Out Large Capacity Crisper, Automatic Defrost, Stainless Steel Shelf Fronts and Door Lock Included
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text:
Stanley Hospital receives at least one cracker blast victim every alternate day
City hospitals have seen many fire accident victims since Deepavali but class VII student Kesavan is among the few who will recover albeit a few scars.
A resident of Manimangalam in Kancheepuram district, Kesaven is now recuperating from two major surgeries on his hands.
"I was holding a cracker in one hand and an ooduvathi (incense stick) in the other. I had turned away to respond to someone who called out my name when the lit end of the ooduvathi accidentally touched the wick of the cracker setting it off," Kesavan said.
The cracker blew up his hands, damaging his left thumb irreparably. The flesh on his right hand was burned in four places.
His family rushed him to Government Stanley Hospital's plastic surgery department which is renowned for re-implanting and reconstructing damaged limbs. Over the past fortnight, plastic surgeons have reconstructed his left palm and are in the process of creating a skin flap for his damaged left thumb.
Three months later, Kesavan will undergo another surgery where plastic surgeons will graft a bone from his rib to create a new thumb on the left hand. It will become as functional as his original thumb as he has several years of growth left, doctors said.
Kesavan is yet to recover from the shock of it all. "I will never again go near crackers," he said emphatically.
According to J. Mohan, head of department of the Institute of Hand and Micro Reconstructive Surgery, at Stanley Hospital, every alternate day, they receive at least one cracker blast victim. "People here burst crackers where to celebrate or mourn. Often, country bombs are the culprits and the damage can be severe."
Reconstructive surgeries done at the department are covered under the Chief Minister's comprehensive insurance scheme. So far, 434 patients have undergone treatment and another 100 or so are awaiting surgeries, Dr. Mohan said.
The department has received funds of Rs. 93 lakh under the scheme, of which, it has used Rs. 75 lakh to upgrade infrastructure and install facilities such as air-conditioners and a 240 KV generator.


text: Been puzzling over this lately, I know it is unpopular on here and it did badly at the box office having received pretty good reviews (the opposite of MOS really). But, it has its merits as well. Compared with MOS we got the caring, thoughtful Clark we are used to. Superman didn't kill anyone! Superman saved a jumbo jet from disaster by guiding it down to safety. Also, he took a bullet to the eye at point blank range and the bullet bounced off, all crumpled up...for me still one of the most impressive strength feats seen in any superhero movie ever. I also liked the story of Superman being the father to a superboy he fathered with Lois. I thought Kevin Spacey was quite good as Lex. Obviously there are elements to that film that make me cringe, but in time, do you think people will look back more favourably on it. I'm thinking of Superman traditionalists who hated MOS..


text:
- Bowhunter85
- 71 contributions
Anyone know if the USDA loan's are going to be extended for the fiscal year? Any details would be much appreciated!
Answers (4)
- Scott White, "swhite11"Lender
- 8 contributions
As of today, I know of at least three companies including Chase that are accepting applications for these loans. Chase sent out a memo detailing exactly how much money was in the coffer now, I'd say as far as USDA Rural is concerned, we're all back in business.
- Aaron Lazenby, "mortgagewithme"Lender
- 99 contributions
As Mitchel mentioned, there is currently a bill on the senate floor which may allow for additional funding. You can follow the progress of the bill here: http://www.govtrack.us/congress/bill.xpd?bill=h111-5017
- Mitchel Marriner, "Mitchel Marriner"Lender
- 15 contributions
There is a bill at the appropriations committee right now waiting to be passed for 55B addtional funds to get them through until Sept. 1 (their fiscal year start)
- James Dunn, "DunnRealtors.com"Agent
- 371 contributions
In my area they are. I would suggest contacting your local office and asking them directly. It's always best to get information straight from the horses mouth.


text:
Comments about 'Evangelicals unveil immigration reform plan'
- Oldest first
- Newest first
- Most recommended
Get religion out of politics.
- 2:11 p.m. June 13, 2012
- Like (5)
- Report abuse
Great, here they go again with the liberal media joining with the churches
trying to fill their pews with more propaganda to get people to accept amnesty
for illegal aliens.
Didn't they try this just last year with the
"utah compact"? Then there was the "dream act" to let
lawbreaking illegals butt in line in front of legal citizens and other would-be
immigrants who are trying to it the right way legally.
At least they
got one thing right, in that our economy is bad - probably the worst it's
been since the great depression, and now is probably NOT a good time to discuss
amnesty for more law breakers wanting to stay in our communities and get more
freebies from the taxpayers.
- 2:16 p.m. June 13, 2012
- Like (7)
- Report abuse
The religious groups do not want to lose their paying customers. It is all about money!
- 2:41 p.m. June 13, 2012
- Like (7)
- Report abuse
Jazz Bass Man: if you actually look at the facts you'll see that government
spending on illegal immigrants is considerably lower per capita than on any
other segment of the population, and any real economist will tell you it's
quite plain that illegal immigrants have overall been a net boost to our
The US has had dozens of recessions in its history, and
irrational anti-immigrant fervor has skyrocketed every single time. Blaming the
Irish, the Germans, the Italians, the Chinese and Japanese, and now the Mexicans
is the same pattern of lazy thinking. Too many people would rather fall back on
racist prejudices than deal with the facts.
It's quite likely
that some of your own ancestors only made it to the USA because after
recession-linked anti-immigrant fervor started to die down clearer heads
prevailed in overturning bad immigration law.
- 3:22 p.m. June 13, 2012
- Like (4)
- Report abuse
"...opponents have misrepresented each other's positions as open
borders and amnesty versus deportations of millions. This false choice has led
to an unacceptable political stalemate at the federal level at a tragic human
The agenda of this group is obviously amnesty. They try
to draw a contrast where there is none. The Pro Legal Immigration crowd is not
for mass deportation of illegals. They are for controlling our borders and
enforcing existing laws against the hiring of illegal workers. You punish the
lawbreaking employers and you fix the problem. Illegal workers will self deport
when there are no jobs.
When all is said and done, the document is so
vague and generalized as to provide nothing new to the debate.
- 3:37 p.m. June 13, 2012
- Like (5)
- Report abuse
You're using the same misleading tactics that many in
the pro illegal immigration crowd try to use.
1. You lump legal
immigration in with illegal immigration and then pretend that they are the same
thing. By doing so you label the anti illegal immigration crowd as anti
immigration, a very misleading label. Its a tactic those of us in the know are
well aware of. In addition I would love for you to direct us to the study that
specifically states that illegal immigration is a net boost to the economy. In
all my searching the only studies I can find use the same tired tactic of
combining illegal and legal immigration in order to get their pro illegal
immigration numbers.
2. You insinuate that the anti illegal
immigration crowd is racist and devoid of facts when just the opposite is true.
Its the pro illegal immigration crowd that has resorted to misleading
information and name calling (i.e. racists). They use these tactics because
when anyone takes a little time to look at the issue with any level of scrutiny,
they begin find that the arguments of the pro illegal immigration crowd fall
- 4:14 p.m. June 13, 2012
- Like (6)
- Report abuse
There's nothing at all wrong with existing immigration laws except they
don't get enforced.
Lets arrest and/or force those illegal
trespassers already here to return home; THEN we can talk about changing the
- 4:40 p.m. June 13, 2012
- Like (7)
- Report abuse
There is a way for them to work towards citizenship, however most don't
want it, they just want the jobs. Of those who are awarded green cards, many
never claim their citizenship. A green card is looked at as a defense against
You want to enforce our laws and give them a chance for
citizenship? Give them a 90 day window to return home. Remove the 3-10 year
block and let them apply right away. As a condition, the business they work for
will be responsible for $2000 to help with their relocation. Let the compassion
come from those who abused the system. The rest can be returned home by denying
them jobs and an increase in judges and ICE personnel.
Allowing them
to stay and work,is amnesty. They came for the job, that needs to be taken away
to create a deterrent to future illegal immigration.
strangers in the land does not mean giving them others jobs or breaking
countries laws. God told us to obey the laws of the land also. Perhaps they
should read the entire Bible, including though shall not steal lie or covet.
- 4:53 p.m. June 13, 2012
- Like (6)
- Report abuse
Translation: Our organizations tie their growth to Hispanic congregations,
mostly from Mexico. We like that growth, even though many of them are here
illegally (at least 30%).
So, how about granting them amnesty so we can
continue to fill our churches with them?
It is nothing more than PC
pandering to our elected officials who need no encouragement to consider illegal
aliens a protected class until such time that they can seal the deal without
riling the citizenry.
- 5:39 p.m. June 13, 2012
- Like (3)
- Report abuse
Regardless of which side of the issue we all stand on, I find it shameful that 4
years later, no one wants to tackle the immigration issue.
And that's
not an Obama bash. It just continues to be the less important issue that always
gets pushed to the back burner.
No one wants to be the bad guy or take the
political fallout for taking a position.
Meanwhile, the situation gets more
complex and emotionally charged.
Inforcing the existing laws is a place to
start, but obviously that doesn't address all
of the issues at hand,
like the children of immigrants who came here illegally.
Too many skidish
old politicians in our government.
- 5:59 p.m. June 13, 2012
- Like
- Report abuse
Keep the pressure up. I'm a strong conservative who supports smaller
government less spending and amnesty for all illegals who have not committed a
more serious crime than overstaying their visa or fleeing a deportation
Grow the pie, let amnesty reign.
- 5:59 p.m. June 13, 2012
- Like (3)
- Report abuse
Rods in AZ is proof positive that you can succeed in America without the benefit
of correct spelling. So let the law breakers in, documented, educated or not,
but please extend that equitably to all countries and crimes. I really would
like a break on my outstanding speeding tix and that one accidental hit and
And I've been skittish about the skids I left on my
neighbors lawn, so let leniency reign and throw caution to the wind. Who values
the rule of law when none will enforce it anyway? What a joke. There's so
many wolves in the sheep pen that we're negotiating with the baby wolves
'cuz they're so cute and hungry.
- 6:28 p.m. June 13, 2012
- Like (4)
- Report abuse
@Hunt: you can turn anywhere in the literature to find these facts; it's
not just one isolated study, and I'm not your personal research assistant.
A few of the first google hits: in 2006 the Wall Street Journal, that bastion of
liberal thought, asked 46 economists whether illegal immigration was a net boost
or net drag on the economy; all but two said illegal immigration was a boost to
the economy. In Texas, illegal immigrants pay above $400 million more a year in
taxes (sales, property, etc) than they receive in total government services
(education, health care, etc). Everybody who has an incorrect SSN- almost all of
whom are undocumented immigrants- pays into the Social Security system through
payroll taxes but never receives benefits; the result is that Social Security
gets an extra $7 billion every year, helping keep it afloat. Illegal immigrants
produce a huge amount of goods, are paid 20% less than their jobs would normally
command, and thus give us less expensive consumer goods and higher growth.
Your knee-jerk defense of sticking your fingers in your ears and
ignoring the overwhelming evidence out there does your cause no favors.
- 6:39 p.m. June 13, 2012
- Like (2)
- Report abuse
@AZRods, Most of us are aware that children brought here illegally do have a way
to get straight with the law at 18. It's a law that allows them to return
home and come back legally on a student visa or residency. It's a short
wait, they are moved to the front of the line and asks a lot less of them than
the 18 year olds we sent to Vietnam to die.
Nothing has been done
because business and some Hispanic organizations do everything we they can to
fight any enforcement. They were for E-verify until they found out it was
effective, now they fight it in the shadows. If we save this countries
sovereignty we must demand business get it's act straight. The guest
workers are their latest tactic, instead of business paying for visas, the
taxpayer pay for them.
@Prodicus, the 2006 study by the journal
ignores the cost to taxpayers, it ignores the loss of income by Americans and
the 44 economists were on business grants or worked for pro-illegal companies.
Texas study showed a billion dollar loss once local costs were
added. Cost to taxpayers $113 billion per year
- 7:22 p.m. June 13, 2012
- Like (3)
- Report abuse
Alabama's unemployment has dropped considerably since their laws were
passed. A chicken processing plant lost 130 illegal workers, next day 250 people
showed up. White, Black, Hispanic, the plant finally has diversity.
Could the Deseret news try to be more moderate in their choice of articles
they pick? It seems we are getting one side all the time, a more balanced
approach would be more fitting considering the papers standards.
- 7:27 p.m. June 13, 2012
- Like (3)
- Report abuse
It's solidly amazing that people still buy into this "net boost" stuff, and other false rationalization for allowing unfettered invasion of this homeland, and unrestricted access to all the benefits we have that are covered by the good old U. S. taxpayer. Meanwhile, we spend literally trillions on the other side of the planet trying to remake their cultures and customs, in these unconstitutional, unaffordable, and unwinnable "wars." Every day I wonder what happened to this once-great, now bankrupt nation. We turned it over to people that were trusted, but obviously totally untrustworthy. Now we have the ecclesiastical community wanting the American taxpayer and citizen worker to carry their baggage as well, which is a genuine travesty, in my opinion. If they want to help out the poor little invaders, chaperone them back to their homelands, and help them build decent communities there. We can't carry and rehabilitate the entire planet--even though we keep trying.
- 7:30 p.m. June 13, 2012
- Like (3)
- Report abuse
@RRB: You can't face the evidence when it fails to confirm your
preconceived biases, so you invent fabrications about it instead so you can
dismiss the facts. The 2006 studies did not ignore any of the factors you
mention, and these economists are not on the payrolls of any pro-immigration
organizations (they're at top universities or the Fed or the CEA).
Try talking to somebody who actually has some expertise in economics
rather than deciding that you're the world's number one expert. It
really doesn't sound like you have even understood Econ 101 level concepts;
you seem to think employment is a zero-sum game.
- 9:14 p.m. June 13, 2012
- Like (2)
- Report abuse
Insulting the person instead of sticking to the facts loses the
None were government, as a matter of fact, the article is
still on the internet. Here is a quote, read the last sentence.
"David Wyss, chief economist at ratings agency Standard & Poor's,
said he believes that undocumented workers have been a net positive. But, he
said, "That doesn't mean there are no negatives, particularly for state
health and education costs."
Simple supply and demand, more
work, less workers, wages go up. Less work, more workers, wages go down. Surplus
illegal labor destroys the lifestyle of our low and middle class workers.
More important, it's illegal. Don't sidetrack the real issue.
- 9:39 p.m. June 13, 2012
- Like (2)
- Report abuse
I'm not going to respond to most of the fallacies that
you continue to perpetuate. RRB has done a good job of that.
I found
this quote from you particularly interesting:
"Everybody who has
an incorrect SSN- almost all of whom are undocumented immigrants- pays into the
Social Security system through payroll taxes but never receives benefits; the
result is that Social Security gets an extra $7 billion every year, helping keep
it afloat."
So in your argument for illegal immigrants you point
out one of the biggest crimes being perpetuated by them. Identity theft.
I'm still trying to wrap my brain around the fact that you think stolen and
falsified SSNs is a good thing. SSNs are being stolen at an alarming rate, over
50,000 SSNs of children in Utah alone. Some SSNs assigned to new born children
have already been in use for years. Identity theft and document fraud are not
victimless crimes despite our media's refusal to report on the damage. To
pretend that no harm is being done and that illegals present a net positive is
frankly laughable and a losing argument in the face of the real facts.
- 10:52 p.m. June 13, 2012
- Like (2)
- Report abuse
Not sure my original transmission got sent, so here goes (again).
Are you sure you want to make the claim that the Wall
Street Journal is "...that bastion of liberal thought?" If you do, then
both @Hunt and @RRB have good reason to question the validity of your arguments.
If you really believe the WSJ is a "...bastion of liberal thought...",
then apparently you are not aware that the Wall Street Journal is ultimately
owned by News Corporation, (a Rupert Murdock property), which also owns Fox
News, a broadcast media that most liberals love to hate.
As a
conservative Republican, I am a fan of the Wall Street Journal, because of all
things it is not a liberal rag like the New York Times - far from it.
- 1:34 a.m. June 14, 2012
- Like (1)
- Report abuse
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text:
Unlike most of the Republican Party establishment who live in the hermetically sealed bubble known as Washington and fight for nothing more than the next 24-hour news cycle, I actually talk on a daily basis to the people who do most of the living and dying in this country.
Based on those conversations, I can safely say any Republican in America who supports raising taxes in any way, shape or form and has aspirations of running for president in 2016 will be dismissed quicker than you can say Thaddeus McCotter.
I may host a nationally syndicated radio program, which debuted this week on WTNT in the nation's capital, but I still live in the first-in-the-nation caucus state of Iowa, which most in the ruling class consider flyover country. While writing about the 2011 Iowa Straw Poll for this newspaper, I correctly predicted the top five finishers in order. I did so not because I'm clairvoyant but because I talk to the patriots in the GOP grass roots, while most of the media talk at them.
Back when the 2011 Iowa Straw Poll was the first benchmark of the 2012 GOP presidential campaign, the debt ceiling was being discussed with the same level of panic the "fiscal cliff" is causing. Just two GOP presidential candidates back then urged the party to stand its ground in the name of principle and prudence -- Rep. Michele Bachmann and Rep. Ron Paul. Guess what? Those two lapped the rest of the field combined as the top two finishers.
Before any ruling class know-it-alls follow the cue of my state's party-establishment governor and dismiss the Iowa Straw Poll, perhaps they should have a conversation with former Minnesota Gov. Tim Pawlenty, because that event cost him his presidential campaign. True, neither Ms. Bachmann nor Mr. Paul eventually won the Iowa Caucuses (Mr. Paul finished a close third) but that was the first time in the history of the Iowa Straw Poll its winner didn't finish first or second in the Iowa Caucuses. Translation: The Iowa Straw Poll is historically a pretty accurate barometer of where the Iowa Caucus voters really are.
Despite misgivings about Mrs. Bachmann's lack of executive experience and Mr. Paul's foreign-policy ideas, grass-roots conservatives gave them the nod because they wanted to send a message to the national Republican Party that there is no more ground to surrender when you're bankrupt and printing a fiat currency. It's not just as simple as balancing the budget, but the size of government is too big -- and unsustainable to boot.
On the heels of yet another party-establishment candidate losing a presidential election, I'm hearing the same battle cry from these conservatives regarding the fiscal cliff.
I'm not just hearing that from Iowans. I hear it from listeners all over the country I talk to each night, including in South Carolina -- another crucial early state in the GOP presidential primary calendar.
They are furious with Speaker John A. Boehner's "surrender now before it's too late" negotiating. They have noticed that the same Republican Party establishment mouthpieces who told them Mitt Romney was the only candidate who could win "the most important election of our lifetimes" are many of the same people now going along with some of the president's fiscal policies they just told us had to be defeated at all costs. They couldn't care less about the soulless technocratic side of politics and its cynical adherents, such as Karl Rove, because they think they are fighting for no less than the survival of their very way of life.
Those same patriots do not want to cut deals with progressives whose utopian schemes have all but destroyed Western Europe. They want to defeat them before we follow in those footsteps. They're finished supporting candidates for high office who don't share their sense of urgency no matter how bad the alternative may be, which is why at least 7 million white voters who voted in 2008 didn't vote in 2012. That also may explain why fewer evangelicals and Catholics voted this year than four years ago and why Mr. Romney did even worse with his fellow Mormons than George W. Bush did in 2004.
Anybody who publicly supports or votes to extend President Obama's credit card while at the same time punishing those producing the very wealth (and jobs) this economy so desperately needs still hasn't gotten that message. This is why Republican primary voters will send them another message should they run for president in 2016.
That message is simply this: If you won't support freedom and prosperity, we won't support you.
Steve Deace is a nationally syndicated radio host (stevedeace.com).


text:
Nov 30 2011 | 12:22pm ET
He's got just over a month to make it up to his investors, but John Paulson isn't waiting for the new year to offer his apologies for the disaster that was and is 2011.
"We are disappointed and apologize," he wrote.
Paulson told investors in his Paulson & Co. funds, who have seen their investments lose as much as 44% through October, that he and his colleagues "have learned form the 2011 experience," which Paulson called "the worst in the firm's 17-year history."
Paulson had confidently predicted a U.S. economic recovery, even launching a fund to profit from it. Needless to say, profits were not made.
"At the beginning of the year, we positioned our portfolios with net equity exposure appropriate for growth in the U.S. and an orderly resolution of Europe's sovereign credit issues," Paulson wrote. "As the year progressed our assumptions proved overly optimistic and net equity exposure was too great."
But Paulson promised investors, who gave the firm a vote of confidence last month when few chose to flee the hedge fund, that he is "committed to returning investors to high-water marks." And he'll have to if he wants to earn any more of the incentive fees that have made him one of the highest-paid hedge fund managers in the world during a string of double- and triple-digit returns dating back to 2007.
Jan 29 2015 | 12:37pm ET
In 2011, Filippo Pignatti Morano launched a fund to invest in classic cars. FINalternatives...
Jan 28 2015 | 8:48am ET
Davos, Switzerland seems to have become the hedge fund capital of the world—at...
Jan 30 2015 | 9:14am ET
When it comes to the hedge fund industry, the notion of "build it and it will...
Jan 23 2015 | 1:00pm ET
In our new section, FINtech Focus, we will profile one of these firms each week. While fintech is a broad category, we will be focusing on firms that specifically cater to the alternative investment industry. Read more…


text:
Dr. Charity V. Hix, MD
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- (304) 353-0318
Dr. Charity V. Hix graduated from the University of Iowa Carver College of Medicine in 2000. She works in Charleston, WV and specializes in Ophthalmology. Dr. Hix is affiliated with Thomas Memorial Hospital and Charleston Area Medical Center Memorial Hospital.
Gender: Female
Years in Practice: 15 Years
Languages Spoken: English
Medical School: University of Iowa Carver College of Medicine
Graduation Date: 2000
Hospital Affiliations: Thomas Memorial Hospital, Charleston Area Medical Center Memorial Hospital
Specialties: Ophthalmology


text:
World of Warcraft graffiti in China
[Via The Ironic Gamer]
Filed under: Fan stuff, Odds and ends
Filed under: Fan stuff, Odds and ends
I found this poster outside my apartment in Brooklyn. While not exactly graffiti, I totally thought it was amazing as at that time I was clocking like 50 hours a week leveling my first two alts.
Here is more WOW graffiti taken from the LAX bathrooms.
A rough translation of the OP's post:
Discovered this in a back street after a meal
!!! Pleasantly surprised haha~ the troll is still the coolest looking HOHO - I'll be coming by this place often to admire the work of this expert. Someone's finally using it as a signature piece haha ... the last picture is that of a playing card king! Look closely~ my hand must have shook when I took the picture
The subsequent posts are exclamations about how cool it is. Some are wondering if a ladder was used. Some snide remarks about bad neighbourhoods and vandalism and security not doing their job - seems like negativity is a universal trait :)
OMG the detail! Very talented artist.
But, some of those posts are right, graffiti is vandalism. While it is a work of art, I wouldn't want someone to paint it on the side of MY house.
@7 - Yes graffiti is art and yes it is graffiti. But there is no way a real graffiti artist (im not talking gang-graffiti) would ever spray anything on the side of your house. There is a sort of code that is followed by real graffiti artists and there are certain things that are off limits (personal property, cars, churches, etc.)
"your all worthless, go get laid"
bitch nigga i used to play WoW n i got pussy then n still do bitch
"your all worthless, go get laid"
Weird how someone who didn't think this was awesome managed to stumble upon the page. Kinda stalky, you think?
Anyone can find this site as it is advertised on AOL AIM Express login page! So I am suprised that more Idiots like #9 haven't posted more. Unfortunately that is the price of fame! LOL Long live WI!
This must be a result of not having "The Burning Crusade" until now, a year after the American market. I saw graffiti in a local dive bar bathroom stall, here in Seattle, it read "level 60 priest LFG".
Event | Date |
Love Is In the Air | 2/2 - 2/15 |
Blackrock Foundry Normal and Heroic open | 2/3 |
Darkmoon Faire | 2/8 - 2/15 |
Blackrock Foundry Mythic opens | 2/10 |
Lunar Festival | 2/16 - 3/2 |
Blackrock Foundry LFR wing 1 opens | 2/17 |
Blackrock Foundry LFR wing 2 opens | 2/24 |
Darkmoon Faire | 3/1 - 3/8 |
Blackrock Foundry LFR wing 3 opens | 3/10 |
Blackrock Foundry LFR wing 4 opens | 3/24 |
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text:
Dr. Minako Watabe, MD
Gynecology, Santa Paula Hospital Clinic
- 845 N 10th St Ste 3
Santa Paula, CA 93060 - 1 Office Location
- (805) 525-0215
Dr. Minako Watabe graduated from the Mount Sinai School of Medicine in 2006. She works in Santa Paula, CA and specializes in Gynecology. Dr. Watabe is affiliated with Ventura County Medical Center, Community Memorial Hospital, Simi Valley Hospital and Santa Paula Hospital. She speaks English and Spanish.
Gender: Female
Years in Practice: 9 Years
Languages Spoken: English, Spanish
Medical School: Mount Sinai School of Medicine
Graduation Date: 2006
Hospital Affiliations: Ventura County Medical Center, Community Memorial Hospital, Simi Valley Hospital, Santa Paula Hospital
Specialties: Gynecology


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this is a the best place that I see in wroclaw, It's very big, with artificial wave, thera are a very difficult slides. It's cheap
this is a the best place that I see in wroclaw, It's very big, with artificial wave, thera are a very difficult slides. It's cheap
The aqua park is very good, with several very fast slides, and both indoor and outdoor areas, but the real thing that makes it worth a visit is the sauna and wellness area. There is a biosauna, hot stone room, steam room, Jacuzzi and several Finnish saunas together with all manner of plunge pools, cold showers and an ice machine... More
Within a 10 mins tram/bus ride to reach a good quality water park is quite a rarity in many cities, however one can easily add this into their schedule in Wroclaw. The park itself is rather decent, modern facilities, okay price and well frequented by locals. The sauna area is clothing optional, and has a good mix of dry and... More
Good looking place, lots of attractions, maybe too little for middle aged kids who are too old for kids area and roo young for some serious attractions but still fantastic to spend time. Me and my younger sister were there twice day after day and enjoyed time. So many things to do, fun slides, jacuzzi, wave and other. You shouldn't... More
but good. Of course its cheaper than aquaparks in Berlin but much more expensive that one in Budapest (and smaller)
Well I'm English speaker wonder if here is any lifeguard course in English they could to I would like to have it.i been trying to find but couldn't .any one have idea?
This is a first aquapark I have been to of this scale. The premisses are excellent, everything is well thought out with lockers accessible with an electronic armband, and dedicated family changing rooms. There are plenty water attractions to choose from, from shallow pools for toddler to the crazy slides for the adults. There is also an outdoor area for... More
The place has a fitness center, a spa and an aquapark with both indoor and outdoor pools. We thoroughly enjoyed the place, which is both price-worthy and offers entertainment and relaxation for the whole family.
Inexpensive summer fun, nice slides, bit busy in the afternoon but worth every minute. The best aquapark I've been to in central Europe.
Every time I visit Wroclaw, I go to Aqua Park. Perhaps it is my favorite place, because I can relax there and get nice impressions. I like there everything - the pool, the spa center, even the building itself. It is in a good location, because it takes only 5-6 minutes from the bus station. All in all I am... More
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