text:
1. Pilot Joe has been living in a hotel since separating from his wife, but he's starting to think about finding an apartment. Owen, who is one of the auto dealership's weakest salesmen, winds up with an embarrassing dealer car, and Terry goes overboard trying to…
2. Let it Go Joe has been living in a hotel since separating from his wife, Sonia, but he's starting to think about finding an apartment. Owen, who is one of the auto dealership's weakest salesmen, winds up with an embarrassing dealer car, and Terry goes overboard trying…
3. Mind's Eye Joe tries to connect better with his son, Albert, by teaching him golf. But when the school golf team is ready to compete in a tournament, Albert is reluctant to get on the bus.
4. The New Guy Owen and Melissa join Joe's ex-wife, Sonia, and her new boyfriend, Harold, for a charity function at their children's school. Terry does his annual duty as auctioneer for the event and meets an old flame, while Joe winds up hanging out with his bookie, Manfro.
5. Powerless The construction at Owen's house is shut down by the city when it is discovered that the contractor, who has now disappeared, never filed the proper permits. To make matters worse, the electricity is out, forcing Owen and his family to temporarily stay with…
6. Go with the Flow Joe recounts the tale of the first date he's gone on in 20 years. The wild misadventures include a black eye, a potentially embarrassing encounter with one of his employees, an unfortunate piece of advice from Terry, an anxious Little Leaguer and a poorly…
7. Father's Fraternity Joe goes to see his retired father (guest star Robert Loggia), who gives new meaning to the word grumpy. Owen's wife and mother get upset when a commercial for the auto dealership implies that Owen's co-worker, Marcus, is actually Owen Sr.'s son. And Terry…
8. You Gonna Do That the Rest of Your Life? Joe's bookie finds out Joe used to be a professional golfer and decides to use him to hustle a couple of guys. Owen's family becomes concerned over his increasing weight. And Terry gets a new apartment, but the apartment manager job that comes with it is a…
9. How to Be an All-Star Desperate to buy a house after his son develops anxiety issues related to their family situation, Joe decides to bet $25,000 on a basketball game.
10. Back in the S#!t Feeling guilty about his rapid downward spiral, which includes treating his son poorly and having to cut back on staff at his store, Joe decides to stop gambling.
Genres | Drama, Comedy |
Director | Scott Winant |
Starring | Ray Romano, Scott Bakula |
Supporting actors | Andre Braugher, LisaGay Hamilton, Richard Gant, Brian White, Kwesi Boakye, Brittany Curran, Braeden Lemasters, Little JJ, Isaiah Montgomery, Penelope Ann Miller, Jon Manfrellotti, Kyle Davis, Alanna Ubach, Lex Medlin, David Norona, Michael Hitchcock, Carla Gallo, Albert Hall |
Season year | 2010 |
Network | TNT |
Producers | Marshall Boone, Cary Hoffman, Victor Hsu, Warren Hutcherson, Jack Orman, Ray Romano, Rory Rosegarten, Mike Royce, Lew Schneider, Mark Stegemann |
Purchase rights | Stream instantly and download to 2 locations Details |
Format | Amazon Instant Video (streaming online video and digital download) |


text:
Celebrities at Paris Photo LA Opening | Photos
Fergie and Josh Team Up With Sean Penn at Star-Studded Art Opening
Fergie and Josh Duhamel rubbed elbows with Sean Penn, Kevin Bacon, and Rachel Zoe at Giorgio Armani and Vanity Fair's opening celebrations for the Paris Photo exhibition at Paramount Studios in LA yesterday. Other stars at the event included Minnie Driver and Emma Roberts, who is fresh off a whirlwind trip to the Tribeca Film Festival in NY and a stop in London to promote her new film, Adult World. Check out our interview with Emma Roberts from the festival to hear about her new flick!
Fergie has been slowing down on her pubic appearances since announcing her pregnancy earlier this year. She stopped by an amfAR fundraising gala in Sao Paulo, Brazil, earlier this month, but she's been laying low since then. However, she still has new music coming out, including her new song, "A Little Party Never Killed Nobody," that appears on the Great Gatsby soundtrack. She isn't the only Black Eyed Pea who has new tracks coming out — Will.i.am released his solo album, #WillPower, on Tuesday. On the day of the release, Fergie tweeted, "So excited for the brother will.i.am on today's release of his new solo album #WillPower."
Josh Duhamel
Kevin Bacon
Rachel Zoe
Sean Penn
- Eli Manning's wife, Abby, gives birth to a baby girl — Us Weekly
- Kim Kardashian has really mastered one kind of selfie — HuffPost Celebrity
- Who is Rachel McAdams's mystery dinner date? — Lainey Gossip
- Iggy Azalea backtracks after a social media rant — Dlisted
- Rihanna strips down for a sexy spread — ET
- Why Reese Witherspoon dressed up as a guy — JustJared
- Hilary Duff is one hot mom — Hollywood Tuna
- Eddie Murphy shares exciting SNL news — Pink Is the New Blog
- Why Suge Knight is under arrest — The Superficial

subset: commoncrawl


text:
kmychaj [at] gmail [dot] com
Kasia Mychajlowycz is a freelance journalist based in New York, with many trips to Toronto. She has been published by the Toronto Star, Shameless Magazine, on site review, Esquire.com, and The United Church Observer, among others. She's also helped produce radio for WNYC's On the Media.
Kasia graduated in 2012 with a Master's Degree in Journalism from Ryerson University in Toronto.


text:
Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
Saved Recipe The Best Easy Beef and Broccoli Stir-Fry by Chris from Kansas
Monday, Mar 24, 2014 on Food.com
Saved Recipe No Dough Meat Crust Pizza for the Low Carb Dieter by TheDancingCook
Monday, Mar 24, 2014 on Food.com
Saved Recipe Roasted Cauliflower & 16 Roasted Cloves of Garlic by Rita~
Sunday, Dec 22, 2013 on Food.com
Saved Recipe Roasted Cauliflower & 16 Roasted Cloves of Garlic by Rita~
Sunday, Dec 22, 2013 on Food.com
Reviewed Cheese Souffle
Sunday, Dec 22, 2013 on Food.com
"I was about to enter my mom';s recipe for my cookbook when I found this - exactly how we have made cheese souffle for years! Pretty much the Betty Crocker recipe from my 1971 edition. I love using extra sharp cheddar and about a 1/4 tsp. cayenne in the roux. Thanks for the tip about the waxed paper - I';m going to have to try that. This is... "
Reviewed Turkey Soup
Saturday, Nov 30, 2013 on Food.com
"My husband made this soup while I was working Black Friday, and I came home to possibly the best soup I';ve had. Ever. I';m not exaggerating! The flavor is so perfectly balanced, and I just love it. Thank you!!!" "
Saved Recipe Kittencal's Italian Melt-In-Your-Mouth Meatballs by Kittencalskitchen
Monday, Nov 18, 2013 on Food.com
Shared Recipe Creamy Crock Pot Chicken Noodle Soup
Monday, Sep 30, 2013 on Food.com
"This recipe uses no canned soups! I found it on Pinterest/Facebook and unfortunately can't credit the originator. I couldn't find it's equal among all the other Creamy Chicken Noodle Soups on Food.com, so here it is!"
Saved Recipe Greek Potatoes (Oven-Roasted and Delicious!) by evelyn/athens
Friday, Aug 2, 2013 on Food.com
Reviewed Pasta and Sausage in Tomato Cream Sauce
Tuesday, Jul 30, 2013 on Food.com
"I really love the flavor of this, but I like the sauce thicker, so I just do a gravy-like method of thickening with flour in cold water added to the sauce. SO yummy!" "
Shared Recipe Tuxedo Pasta (Served Warm)
Monday, Jun 17, 2013 on Food.com
"I love this recipe for a light summer evening meal. There are similar bowtie pasta salads, but this one is meant to be served warm. (So watch your timing, and have everyone ready to eat as soon as you have it all put together!) I have also started adding artichoke hearts to this recipe."
Saved Recipe Olive Garden Pasta E Fagioli Soup in a Crock Pot (Copycat) by ravensmith
Saturday, Oct 1, 2011 on Food.com
Saved Recipe French Dip Roast Beef for the Crock Pot by The Big Cheese
Saturday, Oct 1, 2011 on Food.com


text:
Fabric: Textile and Leather upper, Textile lining and Other Materials Sole.
Product Care: To maintain appearance we recommend removing any light marks with a clean damp sponge or cloth.
Style: Nylon Running.
Ellesse Rocco Skinny Poly Legging $60.50
Brave Soul Alpine Unfilled Jacket $30.50 RRP $75.50
Jack & Jones Athletic Polo Shirt $23.00 RRP $33.50
Crep Rain and Stain Shoe Care $15.00
Good For Nothing Cryptic Cut n Sew T-Shirt $45.50
Ellesse Exhibition T-Shirt $33.50
Converse Womens Chuck Taylor All Star Ox Leather Mono Trainer $83.00
Converse M19 Core Chuck Patch T-Shirt $33.50
Nike Roshe Run Trainer $105.50
Adidas Originals ZX Flux Mesh Trainer $105.50
Nike Air Max Thea Trainer $128.00
Adidas Originals Gazelle Indoor Trainer $101.00
Nike Free Run 2 Trainer $120.50
Adidas Originals Superstar Trainer $98.00
Adidas Originals Stan Smith Trainer $98.00
Nike Stefan Janoski Max Trainer $143.00
Converse Chuck Taylor All Star Ox Trainer $68.00
Nike Air Max 90 Leather Trainer $150.50
Converse Chuck Taylor All Star Hi Trainer $75.50
Adidas Originals Stan Smith Leather Trainer $116.00
Nike Air Force 1 Low Trainer $105.50
Our website uses cookies, as almost all websites do, to help provide you with the best experience we can. For more information on the cookies that our site uses click here. By continuing to use this website, you agree to the use of Cookies.


text:
Dept. of Pharmacology, SL 83
School of Medicine
Tulane University
1430 Tulane Ave
New Orleans, LA 70112
tel 504-988-5444 or 800-347-5935
fax 504-988-5283
Course Directors: Milton Hamblin, Prasad Katakam & Sarah Lindsey
(Dept Tel: 504-988-5444; Emails: email@example.com, firstname.lastname@example.com, firstname.lastname@example.com)
The format for the course will be similar to that of Advances in Pharmacology and will consist of 14 class sessions centered on specific topics (listed below). At each session there will be a presentation by a group of 3-4 students based on a manuscript selected by the course directors. Every student will participate in TWO (2) presentations for the class. At the first class meeting, students will have the opportunity to sign up for the 2 papers that they wish to present. Student groups must set up an appointment to go over their presentation with the faculty member for their topic at least ONE (1) week before their presentation.
By the end of the course you will have participated in the presentation of TWO (2) papers.
The three primary objectives of the course are to:
All students are expected to have thoroughly read each paper prior to the day of class, and to show up prepared to ask questions and provide criticism on the papers! Each team of discussants should
provide the class with a ~30-40 minute discussion that includes the following components:
Grading will also be based upon:
1430 Tulane Avenue, SL-83, New Orleans, LA 70112 504-988-5444 firstname.lastname@example.com


text:
Nintendo DS Cell Phone Charm
Totally Geeky or Geek Chic? Nintendo "DM" Cell Charm
If you're a hardcore Nintendo follower you have probably already feasted your eyes on the DS Cell Phone Charm, but for the rest of you here's a geeky - albeit girly - treat. When our resident tech spy wasn't snapping photos of LG ads in Korea and Japan, he managed to pick me up this adorable "Nintendo DM Lite" cell phone charm. Instead of the double LED screens it sports a "Dobble Mirror" so you can check and make sure your lip gloss is popping before making a call. A replica of the Nintendo DS Lite, this Nintendo DM Lite even features the token A, B, X, Y and D-Pads, but sadly does not include the new camera and Face Training game add on or Nintendo Wi-Fi connection. Sigh. A girl can only ask for so much. Is it chic enough to accompany your cell?
Thanks, Chuger!
Video games
- 7 cheap tech gadgets that actually work — PureWow
- The new wearable device that can track your pet's location — NotImpossibleNow
- Find out which studios own the rights to which Marvel characters — Co.Create
- The cocreator of the laser passes away at 99 years old — RealClear
- What to know about Microsoft's new Outlook app — ReadWrite
- Airpnp — basically Airbnb but for public restrooms — BuzzFeed Tech
- Fall asleep to the sound of Jeff Bridges's voice tonight — POPSUGAR Fitness


text:
Los Justicieros (Arcade)
missing cover art |
100 point score based on reviews from various critics. ...
5 point score based on user ratings. |
West life is nothing easy. Especially if we consider that in most of the towns exists a series of people who suffer from two defects: avarice and presumption. This is the case of the Zorton Brothers, two gunmen and real bad guys who think that they are the center of the world, and that all the other mortals must obey them. In addition, they enjoy killing the weakest and making them suffer, something that we are sure you, intrepid "justiciero", can't allow anymore.The Zorton Brothers have arrived at a calm, Pacific town whose sheriff acts as more decorative than practical. He is small, weak, without aim and too talkative. Before this panorama, the Zorton have decided to seize the town with the inestimable aid of their band. It is up to you to save the town from their clutches.
Los Justicieros is a conversion of the Laser Disc arcade game Zorton Brothers, made by Picmatic on 1993. It was the first Spanish FMV game ported to PC.
There are no Arcade screenshots for this game.
There are 16 other screenshots on file for other versions of this game.
Alternate Titles
- "Zorton Brothers" -- Arcade title
Part of the Following Groups
User Reviews
There are no reviews for this game.
The Press Says
There are no rankings for this game.
There are currently no topics for this game.
There is no trivia on file for this game.
There are no game credits on file for this release of the game. Everything in MobyGames is contributable by users.


text:
You have all followed me along this journey -- when I started with Nutrisystem and lost 80 lbs., then got sick last summer and gained 35 lbs back, and even when I lost those 35 lbs recently. I have talked about my health struggles and my struggle to lost weight. On a whim, I got some allergy testing done. Now, I had scratch tests done for … [Read more...]
What are you allergic to? #EyesonVISINE
As I have mentioned here many times, I am allergic to life. Yes, really! I had allergy testing many years ago, and I reacted to every single thing. I know that it is totally crazy, so of course it happened to me. I also will be having food allergy testing done shortly, because a food allergy keeps showing up in my bloodwork. However, I am not alone. Did … [Read more...]
Join Me At #WellAtWalgreens Twitter Party 3/18 1:00 PM EST
It is hard to believe that we are finally heading out of winter. With the fifty degree day here in Illinois, the snow is finally melting. (I'm purposely ignoring the fact that they are predicting snow tomorrow night!) That being said, with all these changing temperatures, Walgreens is my secret weapon for this time of year. This is the … [Read more...]
Back To School Tiny Prints Giveaway!
As you all know, I am a huge Tiny Prints fan. I've had nothing but great products and great customer service with them. They are known for their awesome Christmas cards, but did you know that you can go Back to School with Tiny Prints? A few of the Back To School Tiny Prints products include personalized notebooks (don't have to worry about your kids losing … [Read more...]
- 1
- 2
- 3
- 4
- Next Page»


text:
10 In To 15 In 4 In To 5 In Shower HeadsCurrent Filters
Diameter: 10 In To 15 In Height: 4 In To 5 In Refine your Results
style height Compare More Colors & Sizes Available Compare More Colors Available $220.99 to $240.49 Save up to 35% In Stock Compare More Colors & Sizes Available Compare More Colors Available $236.00 to $315.00 Save up to 50% In Stock
Ads by Google |
Your Recently Viewed Items
You have no recently viewed items. After viewing product detail pages or search results, look here to find an easy way to navigate back to products you are interested in.
Your Recommended Items
You currently have no recommended items. Browse a few more items to give us an idea of what you like.
©1999 - 2015
Copyright notice | Site Map | By using this site you agree to our Terms & Conditions of Use and Privacy Statement


text:
My Cart
Store Locator
VIP Membership Terms: Normally $24.99 per year, but your Web Exclusive deal means you enjoy 3 months of VIP Family Benefits for $1.99. Check out your savings and benefits below.
Cancellation: Rest assured you can cancel your new membership at any time during the year at a pro-rated rate, simply call your VIP Hotline at 800.543.7309 or click here to submit your cancellation request. Benefits and prices are subject to change.
Want more info? Click here and read 'til your heart's content or call your VIP Hotline at 800.543.7309
Mens Brooks PureGrit 2 Trail Running Shoe - Black/Neon 11.5
Available in Black/Neon
Men's BROOKS� PUREGRIT 2 :: Tackle any terrain in the ultra-light men's Brooks� PureGrit 2. Leap over obstacles and enjoy an ideal connection to Mother Nature in this minimalist trail running shoe. Get great grip on any surface with the updated aggressive outsole. Enjoy natural flexibility with Brooks� Toe Flex ...
Mens Brooks Adrenaline ASR 9 Trail Running Shoe - Red/Charcoal 9
Available in Red/Charcoal
Men's BROOKS� ADRENALINE? ASR 9 :: Feel like a fine-tuned all-terrain vehicle when you're charging on or off-road in the Men's Brooks� Adrenaline? ASR 9. This multi-terrain shoe is like an SUV for your feet. This lighter, less-bulky version feels as good as it looks, featuring excellent flexibility as well ...
Mens Brooks PureCadence 2 Running Shoe - Black/Neon 12
Men's BROOKS� PURECADENCE 2 :: Enjoy all the responsiveness, stability, light weight and flexibility of minimalist running with the men's Brooks� PureCadence? 2. Experience the low-profile styling, unique inverted heels and resilient, responsive feel of this innovative running shoe. You'll be quick on your feet, but you'll still have plenty ...


text:
Choose from our best hostels in Tbilisi, Georgia
Green House Hostel Tbilisi
- Akhvlediani Khevi 13, Tbilisi
- 26th Sep 2014
The hostel feels like a home away from home. The owner, Maia, is very helpful in organizing your trip. It was rather quiet with just a handful of guests when I was there, so if you are after partying in a big group, look elsewhere. For a comfortable, relaxed stay in Tbilisi, this hostel is
bkabelka (Austria) (Male) Avid Traveller
- 11th Sep 2014
After spending 3 nights at the green house hostel, I can honestly say that it felt like home. Maia (the host) is extremely kind and polite, always providing vital local knowledge of Tbilisi and interesting places to visit in Georgia. It is the perfect place to stay if you wish to meet
Anonymous (England) (Male) Novice Nomad
Envoy Hostel Tbilisi
- 45 Betlemi St, Tbilisi
- 19th Jan 2015
The staff at this hostel are fantastic! They were so helpful and friendly. We loved our stay at Envoy :)
Anonymous (South Africa) (Mixed Group) Novice Nomad
- 27th Dec 2014
The Staff were extremely knowledgeable when it comes to directions, city transportation, day trips and so on. They were all very friendly, polite and spoke english for the most part. Breakfast could use an egg, because its very sugary and starchy. The toilet facilities are limited and
lamartimmins (Canada) (Couple) Globetrotter
Boombully Rooms and Hostel
- 24 Rustaveli ave., Tbilisi
- 31st Dec 2014
Location, Rooms, Information, Local Party-Staff
Kitchen (old, little dishes), Noisy atmosphere (for people wanna have it relaxed)
It is a good hostel for people who want to get in touch with the local hosts, who take you to parties etc. The guys are really authentic und
Anonymous (Germany) (Male) Novice Nomad
- 31st Dec 2014
The location of the hostel was great, it was really clean and felt safe. My complaint is that it is a very loud hostel and there is no soundproofing between the rooms and the living area. I think its very unprofessional to have staff that is loud late at night. I was woken almost every
Anonymous (USA) (Female) Novice Nomad
Tbilisi Friends Hostel
- Old Tbilisi, Betlemi Str. #28-30, entrance up from ascent Tumaniani street 9, Tbilisi
- 1st Nov 2014
Very central location and friendly personnel. Definitely worth staying there when visiting the beautiful city of Tbilisi. Having some city info brochures or something similar would be also a good idea.
anarch (Bulgaria) (Male) Novice Nomad
- 22nd Oct 2014
Great atmosphere and very helpful and friendly staff. A lot of reviews mention one broken shower, both showers were working again in October 2014. Bathrooms could be a bit cleaner (and have a little more shelf space), but it's not that bad. The private room doesn't have a window, but if
Anonymous (Germany) (All Male Group) Novice Nomad
Why Not? Tbilisi - Legend Hostel
- Tabukashvili Street 15 Tbilisi, Tbilisi
- 4th Jan 2015
Great as usual. Very convienent localization - just few minutes on foot to metro station, in nearby road there is a bus stop for mashrutha to/from city centre and to airport, fair beakfast, and staff who willing to help you as often as you want, willing to give you information about things
roberth23186 (Poland) (Male) Globetrotter
- 27th Dec 2014
My 2nd time at the Why Not Hostel and probably not my last. I love the homely atmosphere and the amazing staff. Mabloba!
Anonymous (Netherlands) (MALE) Avid Traveller
Old Town Hostel
- Khodasheni str. 7, Tbilisi, Georgia, Tbilisi
- 19th Jan 2015
I LOVE this place! Staff is SO helpful in every way; when I got bit by a stray dog at the flea market, the staff made every effort to call hospitals and taxis and even the manager was so concerned he gave me his phone number in case I needed someone to translate for me at the hospital. The
Anonymous (USA) (Female) Novice Nomad
- 27th Dec 2014
A very good hostel in the Old city center. Stuff girl kindly explained us in English and Russian everything we asked her, even calling somewhere to ask for bus schedule for us. Rooms are all renewed in an old building. Beds are clean, bathroom is bearable, but not perfect. No breakfast
Anonymous (Russia) (Couple) Novice Nomad
Tbilisi Hostel
- Makhati Turn 22,, Avlabari, Tbilisi
- 10th Sep 2014
Loved my stay at Tbilisi Hostel have made friends for life at this hostel. I stayed for 2 nights, went to Mestia and Ushguli and then returned to hostel for 3 more nights. Stayed 5 nights total because the people and staff (Rauf and Zhenya) are awesome. Would recommend to any traveler that
petergaravito3176 (USA) (Male) Novice Nomad
- 20th Aug 2014
There are pros and cons - just make sure you know what you are getting into. The hostel is *not* centrally located. It's on an isolated street, though you can walk (~20 min) to the old town. The communal parts of the hostel are a complete mess. Pyramids of wine bottles, no "front desk" of
Anonymous (USA) (All Female Group) Novice Nomad
Hostel Georgia
- Chitaia 20, Tbilisi
- 23rd Dec 2014
Whoever wants fresh bedsheets should think twice about booking this place. Good only for meeting japanese travellers.
I changed for rooms hostel on Rustaveli av after 1 night.
Anonymous (Germany) (Male) Globetrotter
- 21st Dec 2014
Spent there one night instead of 8, because the shower was awful, it was cold in the room and not much space around. Lowest price in city, but we found much better place afterwards for the same price.
silingas (Lithuania) (Couple) Novice Nomad
Filter Result:
Price Range
Showing between
Showing between
Property Type
Room Type


text:
Security blanket—'safety' boosts Abu Dhabi hotel stays
Safety becomes main feature for travellers opting for Abu Dhabi for vacation, resulting in hotel revenues reaching AED2.53 billion so far in 2011 and as occupancy levels rising to 65 percent in July.
September 6, 2011 2:00 by Reuters
The number of hotel guests in Abu Dhabi jumped 38 percent year-on-year in July, boosted by arrivals from Gulf Arab and Middle Eastern countries ahead of Ramadan, the Abu Dhabi Tourism Authority (ADTA) said on Monday.
The gains also reflect a rise in hotel occupancy throughout the United Arab Emirates this year as some tourists changed travel plans in response to the unrest that has hit other countries in the region such as Syria, Bahrain and Yemen.
Occupancy levels in the hotels and hotel apartments of the oil-rich capital Abu Dhabi rose 9 points to 65 percent in July and revenue was up 6 percent at 271 million dirhams ($73.4 million), ADTA said.
"The regional upsurge could likely be attributed to (GCC) travellers opting to spend time in a destination they associate with safety for their families and with more of them choosing to holiday in July ahead of the holy month of Ramadan when they wish to be at home with their families," said Lawrence Franklin, the ADTA's strategy and policy director.
Ramadan, which this year fell in August, and the Eid holiday that immediately follows it, included shortened working hours and large family gatherings to break the daily fast.
Numbers of guests from the GCC region rose by 98 percent.
Abu Dhabi accounts for 55 percent of the UAE economy and invests billions of dollars in industry, tourism and infrastructure to diversify away from oil.
The emirate hosts many leisure and entertainment events, including a Formula 1 motor racing Grand Prix, as well as major conferences and exhibitions.
"Stability is a vital factor to attract tourists to this country," said Mohamed Amerah, economic adviser at the Ajman Chamber of Commerce and Industry. "Saudis or Kuwaitis used to go to Syria, but Syria is now out of the way, nobody goes there anymore (or) in the foreseeable future."
Year-to-date occupancy levels at Abu Dhabi hotels were up 10 percent to…
Pages: 1 2
More on Analysis
Top 5 things to do this weekend in the UAE
Abu Dhabi to get world's first UEFA concept store
Marina residents may need to recalculate their budgets
GCC education bets on smart learning
Did you know this about chocolate?
Grief on King Abdullah's death pours through social media
Middle East investors target Spanish Green shoots
Oil jumps as Saudi king's death feeds market uncertainty
UAE employees' most preferred job
Emirates, Dubai Mall top UAE's home-grown brand rankings
Dubai properties with surging rents
Top tips to run a marathon
UAE residents are not saving enough
Car rental takes over Dubai
Fear no flights, it's still safe to fly
Top 5 things to do in UAE this weekend
Demand for smart-homes rise in Dubai
Five DSF events not to miss
Temperatures to rise in the UAE
Austerity? Not for us, say rich Gulf states as oil slides


text:
Fashion House is an American nighttime soap opera that aired at 9:00PM Eastern/8:00PM Central Monday through Saturday on MyNetworkTV stations. The series premiered on September 5, 2006 and concluded on December 5, 2006. It was produced by Twentieth Television with directors David Hogan, Alex Hennech, Jim Slocum and Jeremy Stanford.
Register to update information, save favorites, post photos, news stories and comments.


text:
Natural Disasters
Technology Helps EMS Mitigate Lightning Risk
You can count the seconds between the thunder and lightning, but by the time you figure out a lightning strike is imminent, it might be too late. This companion article to "When Lightning Strikes" (April JEMS) will show you how weather information services can help you stay safe and evacuate patients by issuing advisories when there's a lightning risk in your area.
When Lightning Strikes: Bolting down the facts & fiction
Did you know that lightning does strike twice in the same place? Read on to test your knowledge of this dangerous natural phenomenon and learn how to treat your patients and keep yourself safe when responding to volatile—and electric—weather.
Buyer's Guide Featured Companies
Featured Careers & Jobs in EMS
Today's Featured Posts
EMS Airway Clinic
Improving Survival from Cardiac Arrest Using ACD-CPR + ITD
Using active compression-decompression CPR with an ITD has been shown to improve 1-year survival from cardiac arrest by 33%.
More >
Massachusetts Ambulance Company Prepares for Hazardous Conditions
Springfield AMR faces the winter storm.
Watch It >
Nightwatch Series Premiere Party
JEMS Editor-in-Chief A.J. Heightman attends the series premiere of A&E's new reality show, "Nightwatch."
More >
Field Bridge Xpress ePCR on iPad, Android, Kindle Fire
Sneak peek of customizable run forms & more.
Watch It >
VividTrac offered by Vivid Medical - EMS Today 2013
VividTrac, affordable high performance video intubation device.
Watch It >
The AmbuBus®, Bus Stretcher Conversion Kit - EMS Today 2013
AmbuBus®, Bus Stretcher all-hazards preparedness & response tool
Watch It >


text:
Aaron Hernandez
Trial of ex-Patriot Aaron Hernandez delayed by weather
ex-New England Patriots star Aaron Hernandez is being delayed by a snowstorm ..... is expected to resume Tuesday. Hernandez is charged in the June 2013 killing ..... testified Friday that Lloyd and Hernandez were cordial but not close, and
Openings expected in murder trial of ex-Pat Aaron Hernandez
New England Patriots star player Aaron Hernandez , as they deliver opening statements in his murder trial days before Hernandez 's old team is due to play in the Super Bowl on Sunday. Hernandez , 25, has pleaded not guilty to
Jury hearing Aaron Hernandez murder trial is sworn in
of former New England Patriots player Aaron Hernandez . The swearing-in happened Thursday ..... begin Thursday. That's just days before Hernandez 's former team plays in the Super Bowl. Hernandez has pleaded not guilty to killing semiprofessional
Hernandez won't be allowed to watch Super Bowl
Former New England Patriots star Aaron Hernandez won't be allowed to watch the ..... County Sheriff Thomas Hodgson says Hernandez is not allowed to watch television ..... other prisoners. Hodgson says Hernandez had always been subject to those
Opening statements likely Tuesday in Aaron Hernandez murder trial
FALL RIVER, Mass. -- Aaron Hernandez once seemed to be a man with a bright ..... will paint a different picture of Hernandez : they will portray him as a killer ..... semiprofessional football player Odin Lloyd. Hernandez was arrested days after Lloyd's
Full jury seated to hear murder trial of Aaron Hernandez
former New England Patriots player Aaron Hernandez . Bristol County Superior Court ..... just before deliberations start. Hernandez is charged with killing Odin Lloyd ..... Lloyd was dating the sister of Hernandez 's fiancee. He has pleaded not
Aaron Hernandez's fiancee could testify against him
Immunity deal for Aaron Hernandez 's beyond say is close to completion ..... Kevin you were in Fall River for the Hernandez hearing today why would Jenkins been ..... case including the sweatshirt and Hernandez was allegedly wearing when Lloyd
Immunity deal for Aaron Hernandez's beyond say is close to completion. In the hopes of her testifying for the prosecution in the former NFL star's murder trial. On the Jenkins has been accused of disposing of the gun used to kill Oden Lloyd spent more than an hour in a closed door hearing with her attorney. In order to consider an offer they could change the dynamics of the prosecution's case against turning and that's. We now welcome in our fox sports one investigative reporter Kevin Bonn who first reported this story. Now Kevin you were in Fall River for the Hernandez hearing today why would Jenkins been important witness for the prosecution. The inability to find the murder weapon has been a source -
Super Bowl the final act of the NFL's worst season
Domestic Violence. Neither the domestic violence crisis, nor the ongoing murder trial of former Patriots tight end Aaron Hernandez , nor any other off-field issue deterred fans or sponsors - who foot much of the bill for a $9 billion business
Immunity order for Aaron Hernandez's fiancee remains unsigned
murder trial for former football star Aaron Hernandez for nearly a week – ever since ..... first round of jury selection for Hernandez 's upcoming trial in the June ..... of the mansion she shared with Hernandez and ditched it – and she were
Aaron Hernandez trial start date drawing near as jury selection continues
charges against former NFL star Aaron Hernandez moved through its eighth day Wednesday ..... prosecutors, three defense attorneys, Hernandez , a court reporter and security officers ..... murder and weapons charges facing Hernandez , the former star tight end of


text:
Dr. Arthur M. Inoshita, MD
Internal Medicine, Arthur M Inoshita MD
- 3003 Loma Vista Rd Ste B
Ventura, CA 93003 - 1 Office Location
- (805) 652-1520
Dr. Arthur M. Inoshita graduated from the University of Arizona College of Medicine at Tucson in 1975. He works in Ventura, CA and specializes in Internal Medicine and Internal Medicine - Geriatrics. Dr. Inoshita is affiliated with Community Memorial Hospital.
Gender: Male
Years in Practice: 40 Years
Languages Spoken: English
Medical School: University of Arizona College of Medicine at Tucson
Graduation Date: 1975
Hospital Affiliations: Community Memorial Hospital
Specialties: Internal Medicine, Internal Medicine - Geriatrics


text:
Now Playing
Most Active Stories
- Find out about infant bones found in Ben Franklin's basement on Secrets of the Dead
- Magician Ricky Jay is profiled on American Masters airing Friday, January 23rd at 9 pm
- "The Black Keys" and "J. Roddy Walston" perform on Austin City Limits on the 31st
- Shakespeare Uncovered airs on Friday, January 30th beginning at 9 pm
- Genealogy Roadshow II visits the Franklin Institute in Philadelphia
Connect with Us
Podcasts & RSS Feeds
All Content |
View all podcasts & RSS feeds |
Shots - Health Blog
3:19 pm
Tue May 22, 2012
Woman Charged In Death Of Fetus Is Out Of Jail
Bei Bei Shuai is out of jail for the first time since March 2011.
Shuai, a Chinese immigrant who lives in Indiana, is still facing charges of murder and feticide following a failed suicide attempt in December 2010, when she was 33 weeks pregnant.
She was released today after posting a $5,000 bond.
A trial is set for Dec. 2, Emma Ketteringham, one of her lawyers, told Shots. A judge ordered Shuai to wear a GPS tracking device, which could cost $2,500 if she's required to wear until the trial begins, Kettingham said.
Shuai's case has galvanized women's groups across the country. They say that if she is convicted, it could set a precedent for further prosecutions on pregnant women for behaviors that could potentially endanger their fetuses.
Earlier this month, the Indiana Supreme Court refused to review a lower court ruling allowing the case against Shuai to go forward.
Shuai was charged after she was abandoned by the father of her baby, left a suicide note, and ingested rat poison.
She was saved and the baby, a girl, was born, but died three days later in her arms.
She is being prosecuted under laws originally intended to punish third parties who attack pregnant women and injure or kill fetuses.


text:
Young Scooter - Colombia (Remix)
Artist: Young Scooter
Featuring: Rick Ross, Baby aka Birdman, Gucci Mane
Producer: Lil Lody
Album: Street Lottery
Avg Rating: 2.5 ( 6 votes )
Birds of a feather flock together, so what better way to prove you're a big deal than rolling with a posse of rap kingpins? An unsigned Booth newcomer based out of Atlanta, Georgia, Young Scooter has managed to recruit Rick Ross, Birdman and Gucci Mane for the official remix of coke-slinging mixtape cut Colombia. Lil Lody's low-key trunk-rattler of an instrumental, the artist and his heavyweight collaborators rhyme about their shared love for the titular country, Cuban women and pushing that white powder. Feeling it? You can find the original version of Columbia and much more on the headliner's Street Lottery street album, available online as of January 1.
Young ScooterRick RossBaby aka BirdmanGucci Mane IndieStreet Banger
Written by richard on 02/20/13
Submit your Rating
You Might Like...
blog comments powered by DisqusTRENDING NOW
- Fast Food Music: How Our Hunger for More is Killing Hip-Hop
- Rihanna & Kanye's "FourFiveSeconds" is a Blue Collar Anthem
- What If Drake Didn't Sign To Young Money?
- Digging Up Your Favorite Rapper's Hidden Internet Gems
- The Liberation of Lupe Fiasco on "Tetsuo & Youth"
- No Money, No Family: Iggy Azalea's Insane Coming to America Story
- A Very Serious Lyrical Analysis of Lil Wayne's "Sorry 4 The Wait 2"
- 2014 Best of the Booth Award Winners (The Complete List)
- Who Was the Worst Rapper of 2014?
- Your Favorite Indie Rapper is Secretly Signed to a Major Label


text:
The Cromwell Arms
4 | AA Evaluado G | Clasificación |
The 17th century oak beamed coaching inn is a family run establishment and having been recently refurbished, has 12 tastefully decorated and comfortable en-suite rooms. One of which is a family room that can sleep up to 6 people. Our bar and restaurant offer a great range of cask ales, draught lagers and ciders, wines and spirits, as well as an extensive menu of fresh home cooked food and daily specials to whet your appetite. We have FREE Wifi throughout, a lawned beer garden with a pagoda and decking for those warm sunny days, two log fires to warm you on those cosy winter nights and a car park for approximately 20 cars.
So, whether you are on holiday, on business or just passing through, a visit here is highly recommended.


text:
From lowering gold and silver prices to sage grouse habitat protection, Nevada's mining companies today face challenges that hurt their bottom line. Yet, many continue to forge on, creatively tackling difficulties and working to advance projects. "Different aspects of the industry are struggling, but our ability to be sustainable is greater now than ever because… [More…]
October 2014: Around the State
Nevada Mining Association Seeks Successor For Long-Time President Tim Crowley, president of the Nevada Mining Association (NMA), has announced his intention to start a public affairs firm, Crowley & Ferrato Public Affairs (C&F). Crowley has reached an agreement with NMA to stay on temporarily as they search for his replacement. C&F is a partnership between… [More…]
Industry Focus: Mining
Mining in Nevada is an industry that has been thriving despite the economic instability of the past several years. Nevertheless, the industry still faces many challenges ranging from public perception and workforce outlook to restoration and regulatory delays. Mining executives representing companies from the industry recently met at the Reno offices of City National Bank… [More…]
Industry Focus: Mining
Mining in Nevada is one industry that has been thriving in recent economically tumultuous times. Even so, the industry is facing a myriad of issues from taxation to regulatory delays and public perception. Recently, executives representing various companies in the mining industry met at the Reno law offices of Holland & Hart to discuss these issues and what the future of mining looks like:
Fred Reeder, Reno-Tahoe Construction; Ben Veach, JBR Environmental; Jeff Thompson, University of Nevada, Reno – College of Science; Jim Faulds, Nevada Bureau of Mines and Geology; Corrado De Gasperis, Comstock Mining; Tim Crowley, Nevada Mining Association • Tom Clark, Holland & Hart [More…]
Is the mining industry paying its fair share? Monte Miller vs. Tim Crowley
Monte L. Miller is the president of Nevadans United for Fair Mining Tax, Inc and argues that the answer is no. In 1989, voters approved a constitutional amendment to the net proceeds of minerals tax of five percent which capped this tax at five percent in the Nevada Constitution. For 22 years, individuals and businesses… [More…]


text: Characters Edit History Talk6 10,439pages on this wiki Category page Sorting type: Most visited Most visited Alphabetical | Characters from the entire Grand Theft Auto series. Pages in category "Characters" Stretch (character) Dom Beasley Dave Norton Victor Vance Wade Hebert Cheetah (stripper) Carmen Ortiz Katie Zhan Kiki Jenkins Ron Jakowski Helena Wankstein Alexandra Chilton Fufu Denise Robinson Molly Schultz Denise Clinton Back 1 2 3 4 5 6 7 ... 125 Next Subcategories Friends " Soldiers who served in the "Fifteen Man Squad" during the Yugoslavian Wars. Fifteen Man Squad Pegorino crime family Characters in GTA 1 Arms Dealers Characters in GTA Liberty City Stories Characters in GTA 2 Artists Back 1 2 3 4 5 6 Next


text:
15 reasons why companies may fear social media
Posted on January 28th 2009
Some industries have built in fan bases and thus are naturals for social media implementation, so .. why the delay? Fear? Lack of expertise?
Fear of social media. It's more prevalent than you think. Sure some will say they are waiting for the true ROI to shake out. That might be true, but I doubt it's the main reason.
Leigh brought up some great points: "Is it Fear? Resources? Ignorance? Unwilling to be transparent?" She goes on to add without mentioning industries, "that some large orgs. are terrified of the VOLUME of feedback and detractors so much they can't see upside."
Can you imagine being so burdened with the fear of negative press or negative reaction, that you, as an organization, are paralyzed into doing nothing?
Leigh concludes: "They are just not comfortable with that level of transparency. Turning a blind eye negates the opportunity to turn around negatives…Treat customers with respect, respond - and identifyadvocates too!
Rachel then adds: I think the biggest inhibitor of adoption of new tools is that people are overwhelmed and don't have time to play with them. Sometimes I think you have to drag people into a room and make them play around with the tools until they are comfortable.
I couldn't agree with them more! So lets review this. Are these the things that are holding companies of all sizes back from utilizing social media?
- Fear
- Lack of experience
- Ignorance
- Waiting for ROI
- Lack of Resources
- Unwilling to be transparent
- Lack of time
- Confusion
- No Money
- Unawareness
- No expertise
- Lack of leadership
- Terrified of feedback/truth
- The "newness" of it, going to wait.
- High degree of skepticism
What else can we add to this list? How many of these are really legitimate?
I think these are all valid reasons many companies, non-profits and government agencies don't engage in Social media. I might ad from some experience that some fear loss of control of their message. What they fail to understand is that control of their message is an illusion. The conversations ABOUT them is already going on in the ether, they just don't know it and they could be helping their brand/cause by being a part of the conversation. These entities are spending resources on damage control rather than being proactive and building their reputation.
I also think that there is an assumption--an incorrect one--that companies aren't listening if we don't see them engaging. In other words, the assumption is that just because we don't see them engaging means that they "don't get" social media. This is a false leap. There are plenty of companies that are listening but have decided not to engage for a variety of factors. There is nothing wrong with that.
Social media is a tool, and a small one, for communications. It's more relevant to some industries than it is to others, too. A B2B company that manufactures steel tubes used in factory construction has little reason to engage in social media--what little benefit they could possibly gain is outweighed by the commitment needed to do social media right. A company that makes a B2C product like candy bars has a far greater need to participate, as its audience is present in large numbers on the web. Social media advocates who push the idea that social media is right/needed for all businesses risk overstating their case and will ultimately lose credibility. Please note that I am making a distinction here between listening and engaging. All companies--even the steel tube manufacturer example I listed--should have some sort of listening system in place, even if it's simply a Google Alert.
Thoughtful post, very interesting.
And, I agree with your point regarding B2B--that there are a lot of elements and that there's likely something that would work well. But, I think in this economic environment, most businesses are focusing on the nuts and bolts of P&L, and that there has to be a strongly compelling reason to change things at this time.
Again, great post and a lot to think about as social media moves forward.
I think a lot of companies fear the lack of control in social media. A minor customer service slip could 'go viral' and have a damaging effect. Companies should not be afraid of engaging their business in social media since almost everyone is into social media.
Social media is tool by which you can generate huge traffic to a perticular website,the main three reason behind companies may fear social media is Lack of experience to generate traffic,waiting for ROI as ROI cannot be generated overnight and confusion regards to the social media.
SEO Reseller


text:
30,642 Dojo and growing
Helping people find Dojo since 2004
Currently online: 1525 Visitors
Most of these Martial Arts Studios, clubs and gyms offer Karate classes for kids or Self Defense classes for children, men and women in Kirklin area. If you are looking for classes or lessons near your address in Kirklin, please use the following search box and see a list of Martial Arts Schools, clubs and organizations near you.
See Martial Arts Schools and classes in places around Kirklin, Indiana: Frankfort, Sheridan, Michigantown, Forest, Whitestown, Kentwood, Kempton.
If you are associated with a Martial Arts School in Kirklin, please list it with dojolocator.


text:
An Oklahoma state senator has introduced a bill that would protect public schools from lawsuits when the Bible is taught as history.
The fifth annual National School Choice Week begins today, January 23.
The Foundation for Individual Rights in Education has announced its Speech Code of the Month goes to Georgia Southern University for adopting an unconstitutional speech policy.
Following an interview with a Christian missionary, author Andrée Seu Peterson was compelled to delve into how political correctness in America has affected how English teachers teach. What she discovered is "a mandate to get rid of language that hurts people's sensibilities."
A California teacher is being investigated after complaints that he was distributing "Bible cookies" to students in class.
The ACLU is going after a Mississippi school district that's requiring students to obtain parental permission before joining a club that advocates for homosexual rights.
A group of Christian colleges and Bible schools has been pushed too far and wants the government of Illinois to butt out of its business. So they have gone to court to try to see that happens.
As school athletic associations are asked to allow transgender youth to play on teams of the opposite gender, Montana residents sent a loud message of opposition.
One researcher sees an opportunity for the GOP to put a stop to the Obama administration's "cradle-to-career" education system.
After the state legislature's approval of a new Arizona law Thursday morning, students who want a high school diploma will need to pass a citizenship test or the hats won't fly at graduation. The law was speedily approved by both houses later in the afternoon and signed by Arizona Gov. Doug Ducey in the evening of the same day.
An observer from a conservative think tank says the president's call for stronger student privacy protections is "bogus."
Forget sitting in the corner or getting sent to the principal's office. Not in Virginia, at least, where a four-year-old preschooler at an elementary school was handcuffed, shackled, and taken by a sheriff in a squad car to the police station. There he was forced to talk to jail inmates to "scare" him straight. And just for safe measure, the school threw in a suspension.
A skeptic of man-made global warming is speaking out against school curriculum in West Virginia.
A cultural analyst isn't satisfied with federal guidance being handed down to public schools as they struggle with how to comply with rules governing accommodation of gender-confused students.
Just a few years after "state-napping" a homeschooled seven-year-old boy from his parents after boarding an international flight to emigrate to India – and keeping them from seeing him for three years – Swedish officials are at it again. This time they are pursuing their agenda through Sweden's Supreme Court, as they continue to violate the human rights of a Swedish-American couple by denying their application to homeschool their elementary-age daughter.
Atheists and humanists from a few communities around the country are starting their own after-school clubs to push back against the Child Evangelism Fellowship, claiming the clubs sponsored by CEF are a negative influence.


text:
Internet Resources - Encyclopedias
- Encyclopedia Britannica
Contains full text of encyclopedia articles, including illustrations such as photographs, drawings, maps, and flags. Also includes an atlas, dictionary, thesaurus, selected video clips, and links to over 200,000 related websites reviewed by Britannica editors.
Browse related subjects: Encyclopedias - Gale Directory Library
Online reference that includes Encyclopedia of Associations: International Organizations, Encyclopedia of Associations: National Organizations of the U.S., Encyclopedia of Associations: Regional, State, and Local Organizations, and National Directory of Non-Profit Organizations
Browse related subjects: Associations, Charities, Directories, Encyclopedias - World Book Online
The online version of World Book Encyclopedia includes more than 26,000 articles, 12,000 pictures and maps, and 7,000 links to editor-approved Web sites useful in helping students constructively explore topics further. In addition to the encyclopedia, features include an atlas, a dictionary, and resource guides on selected topics.
Browse related subjects: Encyclopedias, Teen Homework Help
Did You Know?
Geographic Facts - Santa Cruz City
* Latitude: 36.59 N
* Longitude: 122.02 W
* Area: 13.3 sq. miles
* Elevation: 20 ft. above sea level
Browse and search more fun and useful facts from the SCPL Reference Files!


text:
Search | About | Preferences | Interact | Help | ||
150 million books. 1 search engine. |
Mozart authority H.C. Robbins Landon leads a team of more than 20 of the world's greatest Mozart scholars in an exploration that touches virtually every facet of the composers life--from the profound influence of his father, to his emotional attachment to his wife, even to his personal attitudes toward death. Two 8-page photograph inserts.
Search under way...
Search complete.
New books: 1 - 25 of 28
Used books: 1 - 25 of 165


text:
Log inRegister | ||
Submit Complaint |
Share this site with othersRecently Updated ComplaintsLevis Jeans/commuters Jeans - Jeans altered short/ shrunk
I bought a commuter jeans at Infinity mall Malad and got... SBI - I want to know my CIF Number
Hi I want to know my CIF Number. My Account number is... Usha International Ltd - Pathetic after service by USHA…Now a big looser electric...
We logged a ticket on USHA customer care regarding my new... snapdeal - Not Returning my order
Hello snapdeal i have got the worst service from your site... LIC OF INDIA - Forgot Email ID, User ID and Password
I am registered costumer of LIC of India. But I am unable... Whatsapp - Temporary bannned
My phone number is +919465106184 My watsapp has been... samsung s3 - Lost/Stolen mobile
HI There, Today (26 Jan 2015) I lost my mobile at... NIRMAL BABA G - problems
baba ji ke charan mai koti koti pranam. mera nam hai j... snapdeal - Faulty Product
I purchased micromax knight A350 bu it is faulty product... email@example.com - name change
sir, this is to submit that i have filled a complaint... |
Reviews |
Complaints |
Submit Complaint |
View full list of Companies |
Latest Complaints |
Terms of Use |
Privacy Policy |
Contact Us
© Indian Complaint Board Forum |


text:
November 10th, 2011 at 9:13 am
'Burn Notice' Fans Can Chat Online with Show Creator Matt Nix During Tonight's Episode
answers fan questions and shares insight into the methodology of 'Burn Notice'
[Read-More]November 10th, 2011 at 8:57 am
Republican Presidential Candidate Rick Perry To Present Tonight's Top Ten List on CBS's 'Late Show with David Letterman'
this will be Gov. Perry's first visit to the CBS broadcast.
[Read-More]November 10th, 2011 at 8:54 am
ABC Dominates Wednesday with a Growing CMA Awards
With its broadcast of "The 45th Annual CMA Awards," ABC dominated Wednesday night, beating out its nearest competition on the evening by
[Read-More]November 10th, 2011 at 8:45 am
TV Ratings Wednesday: 'CMA Awards' Pace ABC Win; 'X Factor,' CBS Fall; 'Harry's Law' Rises, 'SVU' Sees Lows
ABC won the night with adults 18-49 and total viewers.
[Read-More]November 10th, 2011 at 8:08 am
New HBO Comedy 'Angry Boys' Premiere Moved A Week Earlier to January 1, 2012
will kick off it's 12 episode first season on January 1.
[Read-More]November 10th, 2011 at 8:02 am
Sullivan Stapleton and Philip Winchester to Return to Cinemax's 'Strike Back' Next Season
Rhashan Stone And Michelle Lukes Also Return
[Read-More]November 10th, 2011 at 7:57 am
ABC's Jimmy Kimmel Live Pulls in its Biggest Audience of the Season Oct. 31-Nov. 4
During the week of October 31, 2011, ABC's Jimmy Kimmel Live grew over the prior week by 6% in Total Viewers and
[Read-More]November 9th, 2011 at 11:10 pm
Tuesday Final Ratings: 'Dancing With the Stars' Adjusted Up; No Adjustment for 'New Girl'
Tuesday's final ratings.


text:
The Mummy: Tomb of the Dragon Emperor Gallery
Brendan Fraser returns as explorer Rick O'Connell to combat the resurrected Han Emperor (Jet Li) in an epic that races from the catacombs of ancient China high into the frigid Himalayas. Rick is joined in this all-new adventure by son Alex (newcomer Luke Ford), wife Evelyn (Maria Bello) and her brother Jonathan (John Hannah). And this time, the O'Connells must stop a mummy awoken from a 2000-year-old curse who threatens to plunge the world into his merciless, unending service. The Mummy: Tomb of the Dragon Emperor is released on DVD on December 1, 2008.
Roll your mouse over the left and right-hand sides of the image and then click to view more pictures.
Read our review of The Mummy: Tomb of the Dragon Emperor
Recent Galleries:
- The Revenant (Leonardo DiCaprio/Tom Hardy) First-look Photo Gallery
- Ex_Machina Behind-The-Scenes Photo Gallery
- Ex_Machina (Oscar Isaac/Domhnall Gleeson) Photo Gallery
- The film posters of 2015
- American Sniper (Bradley Cooper) Photo Gallery
- Whiplash (Miles Teller/JK Simmons) Photo Gallery
- Wild (Reese Witherspoon) Photo Gallery
- Taken 3 (Liam Neeson) Photo Gallery 2
- Birdman or The Unexpected Virtue of Ignorance Photo Gallery
- Exodus: Gods & Kings (Ridley Scott) - Photo Gallery


text:
The Hibiscus Flower Cutout measures to be 13" x 13" and can be hung indoors and outdoors. This cutout is perfect for luaus, pool parties, birthdays and more.
More..." Hello there. I am a bride on a budget trying to plan a wedding for December. I have been procrastinating buying all the little things for it cause... "


text:
Small interfering RNA (siRNA) molecules mediate sequence specific silencing in RNA interference (RNAi), a gene regulatory phenomenon observed in almost all organisms. Large scale sequencing of small RNA libraries obtained from C. elegans has revealed that a broad spectrum of siRNAs is endogenously transcribed from genomic sequences. The biological role and molecular diversity of C. elegans endogenous siRNA (endo-siRNA) molecules, nonetheless, remain poorly understood. In order to gain insight into their biological function, we annotated two large libraries of endo-siRNA sequences, identified their cognate targets, and performed gene ontology analysis to identify enriched functional categories.
Systematic trends in categorization of target genes according to the specific length of siRNA sequences were observed: 18- to 22-mer siRNAs were associated with genes required for embryonic development; 23-mers were associated uniquely with post-embryonic development; 24–26-mers were associated with phosphorus metabolism or protein modification. Moreover, we observe that some argonaute related genes associate with siRNAs with multiple reads. Sequence frequency graphs suggest that different lengths of siRNAs share similarities in overall sequence structure: the 5' end begins with G, while the body predominates with U and C.
These results suggest that the lengths of endogenous siRNA molecules are consequential to their biological functions since the gene ontology categories for their cognate mRNA targets vary depending upon their lengths.
The genome of C. elegans contains two principal groups of small RNA species capable of interfering with gene expression. The first, microRNAs (miRNAs), are a class of relatively well characterized small RNAs of ~22 nucleotides (nt) in length derived from a hairpin precursor of ~65–70 nt, that regulate gene expression patterns during organism development and are found from almost all eukaryotes [1,2]. miRNAs are often derived from their own transcript or from intron sequences of protein coding genes [2,3]. Endogenous small interfering RNAs (endo-siRNAs) are a second class of endogenous regulators of gene expression. They are often derived from exons and match perfectly with mRNA sequence of a target gene [3-5]. In contrast, exogenous small interfering RNAs (exo-siRNAs) can be processed from a double stranded RNA (dsRNA) precursor derived from cellular transfections, microinjections, feeding, or from genetic material of invading viruses [7-10]. The biogenesis of exo-siRNAs appears to differ from endo-siRNAs and thus separate pathways for processing and mediating their silencing actions have been proposed [4,5].
According to the current model of siRNA biogenesis, both exogenous and endogenous siRNAs are processed from double-stranded RNA (dsRNA) precursors [7] by Dicer, a ribonuclease III enzyme (RNase III) that cleaves the long double-stranded RNA molecule to yield 21–25 nt siRNAs [2,4]. Subsequent loading of the siRNA into the RNAi silencing complex, followed by action of RNA-dependent RNA polymerase (RdRP) on target mRNA template, yields a population of secondary siRNAs that are able to interfere with gene expression through transcriptional repression, translational block, or mRNA cleavage [2,4,11-13]. RRF-3 is the first identified C. elegans RdRP homolog required for accumulation of at least a portion of endo-siRNAs [4,5]. rrf-3 mutants lack many endo-siRNAs and have an enhanced RNAi phenotype presumably due to release of it's associated pathway proteins from endogenous RNAi (endo-RNAi) to the exogenous RNAi pathway (exo-RNAi) [4,5,14]. Microarray expression analysis of rrf-3 mutants have suggested that endo-siRNAs produced from RRF-3 dependent synthesis regulate a large number of protein coding genes, especially those involved in spermatogenesis and protein phosphorylation [5,15].
Two studies that performed large scale sequencing of small RNA libraries cloned from mixed stage populations of C. elegans have provided initial material for grouping and classification of candidate endo-siRNAs [5,6]. From a preliminary analysis, the existence of a sub-class of endo-siRNAs, referred to as 21U-RNAs, have been discovered [6]. 21U-RNAs are precisely 21 nt long, begin with uridine 5'-monophosphate and originate from more than 5700, primarily non-coding, genomic loci which are dispersed in two broad regions of C. elegans chromosome IV. Absence of complementary mRNA matches suggests that this siRNA type does not operate by a "classical" mRNA degradation manner of RNAi but may direct alternative actions such as modifications in chromatin structure [6]. Another less abundant class of endo-siRNA that arises from non-coding genomic regions has also been described. These candidate siRNA sequences are dispersed all along the genome and are referred to as tiny non-coding RNAs (tncRNAs) [5]. The absence of corresponding mRNA sequence suggests that tncRNAs may function in a manner similar to 21U-RNAs. Both studies [5,6] observed a number of candidate siRNA sequences perfectly corresponding to one or several mRNA sequences. The mRNA match provides strong evidence that this particular class of endo-siRNA is capable of hybridizing with the gene product and interfering with gene expression by a "classical" mRNA degradation manner.
In order to understand the cellular functions regulated by endogenous siRNAs collected from C. elegans, we merged the libraries from two sequencing projects [5,6] containing all siRNA sequences currently available, resulting in a collection of 7136 candidate endo-siRNA sequences. We characterized their length distributions and the relationship of the siRNA with the function of genes targeted. We observed that different lengths of endo-siRNA molecules are associated with functionally different target genes. Moreover, we observe that some argonaute-related genes associate with siRNAs with multiple reads.
Length distribution of candidate siRNA sequences
The large libraries of candidate endo-siRNA sequences obtained by sequencing efforts of Lee and co-workers from the Ambros laboratory, and Ruby and co-workers from the Bartel laboratory [5,6] prompted us to merge the libraries and analyze them by length distribution. From the total of 7136 short RNA sequences, 4024 exhibited antisense complementarity to 2344 known mRNA sequences (Additional files 1 and 2). These putative siRNAs were derived from exon coding areas and corresponding mRNAs were defined as cognate targets.
Additional file 1. The collection of all 4024 siRNAs with putative mRNA targets. The sequences, lengths, and the putative target mRNAs for the siRNAs from two sources (Lee et al., 2006, Ruby et al., 2006) are presented.
Format: XLS Size: KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 2. The collection of all 7136 short RNAs. The sequences, lengths, and the 5'nucleotides of the entire RNA collection from two sources (Lee et al., 2006, Ruby et al., 2006) are presented.
Format: XLS Size: 3.8MB Download file
This file can be viewed with: Microsoft Excel Viewer
Length distributions encompassing all siRNA sequences from the two source libraries are shown in Figure 1a. siRNAs from Lee and co-workers are shown in Figure 1b and siRNAs from Ruby and co-workers are shown in Figure 1c. siRNAs with a mRNA match are shaded and siRNAs without a match are shown in lighter color. In both libraries, the short RNAs not matching with mRNA are widely distributed in length while siRNAs with a match exhibit a more centered distribution. Strikingly, siRNAs with no mRNA match are dramatically overrepresented in the library of Lee and co-workers, while in the library of Ruby and co-workers, the majority of siRNAs match with mRNA. In both libraries, the length distribution of siRNAs matching with mRNA shows a normal distribution arising from a length of 18- to 24-mers with the highest peak at 22-mers (Figure 1b and 1c). A difference arises from the existence of additional 24- to 26-mers in the library of Ruby and co-workers indicating selectivity in the cloning method for these specific lengths of small RNA molecules. In addition, 21-mers are underrepresented in the library of Lee and co-workers when compared with the amount of 21-mers in the library of Ruby and co-workers.
Figure 1. Length distribution of siRNAs. The siRNAs were obtained by high-throughput sequencing of mixed stage C. elegans populations from two library sources (Lee et al., 2006; Ruby et al., 2006). The height of the bars indicates the number of siRNAs for the respective length. The shaded portion of the histograms indicates the number of siRNAs with an mRNA sequence match. A) Length distribution of all 7136 available short RNA sequences from C. elegans available from the two library sources. The length of sequences ranged from 12- to 37 nucleotides. A total of 4024 siRNA sequences matched with an mRNA sequence from the two library sources. B) Length distribution of siRNAs from the library reported in Lee et al., 2006. C) Length distribution of siRNAs from the library reported in Ruby et al., 2006.
siRNA sequences with multiple reads
The abundance (or counts) of individual reads of siRNA sequences was available only for the data from Ruby and co-workers [6]. A total of 125 siRNA sequences were read three or more times with 102 of these matching with mRNA sequences. A list of candidate target genes with 3 or more identical siRNA reads are shown in Additional file 3. Groups of multi-read siRNAs were further observed to exhibit a trend towards overrepresentation of 26-mers (Figure 2). Upon closer inspection, many of the siRNAs with several reads targeted the same mRNAs. When the functions of these putative targets were identified, the "Argonaute and Dicer protein, PAZ" was observed to be significantly enriched as a nomenclature category. The argonaute-related genes targeted by multi-read siRNAs included C16C10.3 (contains PAZ and PIWI RNA-binding domains), F55C9.3 (PAZ) and F58G1.1 (PAZ/PIWI). F55C9.3 was targeted by 16 siRNAs which fell into two length categories: 19- to 20-mers were represented as a single read, while 25- to 26-mers were represented as one to ten reads. All siRNA sites along the gene F55C9.3 (transcript NM_075351) are presented as an example of the distribution of siRNAs along the sequence of the candidate target mRNA (Figure 3).
Additional file 3. The individual siRNAs with the most reads. The data from Ruby et al (2006) contained numbers of individual detections of the sequence and they are presented here.
Format: XLS Size: 989KB Download file
This file can be viewed with: Microsoft Excel Viewer
Figure 2. Length distribution of the multi-read siRNAs. Multi-read siRNAs were obtained from the library in Ruby et al., 2006 as described in the methods section. The lengths were calculated and the number of counts for each nucleotide length was plotted.
Figure 3. Length distribution and target sites of siRNAs complementary to Argonaute-related mRNA NM_075351 (F55C9.3). The siRNA identifier, number of reads, length, siRNA sequence, and position along the transcript is shown. The short bars indicate the position along the transcript and the numbers indicate the nucleotide position along the sequence. There are one to two nucleotide shorter versions of certain siRNAs that have been read multiple times. The number of reads was not available (n.a.) in some cases because those siRNAs were obtained from Lee et al. (2006).
Gene Ontology terms correspond to specific siRNA lengths
The targets for each length category siRNA were associated with the specific Gene Ontology (GO) terms shown in Table 1 and Additional file 4. The 18- to 22-mers were associated with the term embryonic development while 23-mers were uniquely associated with post-embryonic development. Longer siRNAs were linked to other GO terms. The 24- to 26-mer siRNAs were linked to phosphorus metabolism or protein modification.
Additional file 4. The full list of the enriched GO terms of siRNAs by length. Target gene lists were submitted to DAVID 2.0 as described in methods. The 10 most significant GO categories are shown for all siRNAs with a putative target. The 5 most significant GO categories are presented for the siRNAs according to their length.
Format: PDF Size: KB Download file
This file can be viewed with: Adobe Acrobat Reader
Table 1. The enriched GO terms for target genes of endo-siRNAs.
Nucleotide sequence of siRNA molecules
The starting nucleotide was previously shown to be guanine (G) among 85% of endogenous siRNAs in the library of Ruby and co-workers [6]. Thus, it was of interest to measure the most common starting nucleotide after combining libraries. After plotting the starting nucleotide of siRNA sequences against their length, we observed a similar trend with G as the most abundant first 5' nucleotide (Figure 4). Shorter siRNAs exhibited uracil (U), cytosine (C) or adenine (A) frequently as the starting nucleotide. Furthermore, we constructed frequency sequence graphs (logos) for 4024 siRNA sequences of 12–29 nt in length with an mRNA match (Figure 5). All lengths of siRNAs prefer G in their 5' end and C in their 3' end with both A and U largely represented along the body. All siRNAs from the combined library exhibited an average A/U content of 53.1%, while A/U content of all mRNAs was previously reported to be 42.7% [16] and 64.6% in the whole genome [17]. 12- to 16-mers exhibit variable 3' nucleotides (A, G or U) suggesting that short sequences are potential degradation products of longer sequences. To address this question, we aligned siRNA sequences and observed that 5 of 25 sequences (20%) among 12-mers and 3 of 22 sequences (13.6%) among 13-mers could be found from longer siRNA sequences (Additional file 5). Frequency sequence graphs were generated also for the combined library of 7136 RNA sequences (12- to 33-mers) including those without mRNA matches (Additional file 6). Results were similar between the two sets of frequency sequence graphs.
Additional file 5. Redundancy and fragments of short siRNAs. The number of short siRNAs that were aligned with longer siRNAs are presented on the first leaf. On the second leaf, the siRNAs (siRNA1) whose sequence is included in one or more longer siRNA sequences (siRNA2) with a perfect match are presented.
Format: XLS Size: KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 6. The frequency sequence graphs (logos) of the whole collection of short RNAs. The sequences included those without putative targets from Lee et al. (2006) and Ruby et al. (2006). The number of siRNAs in each length category is shown on the right.
Format: PDF Size: KB Download file
This file can be viewed with: Adobe Acrobat Reader
Figure 4. The distribution of 5' nucleotides in siRNAs grouped by the length. Each bar represents the percentage of siRNAs for the given length. The shading indicates the 5' starting nucleotide.
Figure 5. The frequency sequence graphs (logos) of siRNAs which have putative target mRNAs. siRNA sequences were collected and divided by size as described in methods. Sequence logos were generated using WebLogo http://weblogo.berkeley.edu webcite. The siRNA length is shown on the left and the number of siRNAs in each length category is shown on the right.
Conservation of candidate mRNA target sequences
The conservation of the putative target genes for the siRNAs was inspected by using pre-calculated BLAST similarities between C. elegans and C. briggsae (Wormbase release WS170). 14.4% of genes had perfect matches between the two species, while only 8.8% of the rest of the genome had this score reflecting conservation of siRNA associated genes (data not shown). However, the genes targeted by several different siRNAs were found to be more weakly conserved than the target genes on average (Additional file 7).
Additional file 7. Conservation of genes targeted by several siRNAs. Some genes (mRNAs) were putative targets for many siRNAs. The genes with the highest number of siRNAs appears to be poorly conserved in recent evolution. The homology between the C. elegans and C. briggsae was estimated by precalculated BLAST Expectation (E)-values. The smaller (down to 10^-300) the E-value, the better statistical value for the homology. Certain genes, such as K02E2.6 did not appear to have an ortholog in C. briggsae.
Format: XLS Size: 185KB Download file
This file can be viewed with: Microsoft Excel Viewer
The existence of endogenous siRNAs (endo-siRNAs) encoded by the genome in C. elegans has been reported by several groups [2,4-6]. The evidence for classification of these sequences as endo-siRNAs has been the observation that RNAi machinery is required for their accumulation. In addition, many RNAi pathway mutants exhibit elevated levels of gene expression indicating the loss of regulatory RNAs [5,15]. We combined datasets representing candidate endogenous siRNAs collected to date from C. elegans by high-throughput sequencing efforts [5,6]. Two electronic libraries of endo-siRNAs were gathered and annotated.
The length of siRNAs in a combined data set appeared to be about 22 nt on average, which was observed for siRNA sequences with either matching or non-matching mRNAs (Figure 1a). Examination of the siRNAs as separate groups by the source laboratory appeared to affect their length distributions with 26-mers more highly represented in the library of Ruby and co-workers [6] (Figure 1c). In both libraries, centered distributions of 18- to 23-mers suggest a uniform class of endogenous siRNAs with ability to hybridize with mRNA sequences (Figures 1a, 1b and 1c). siRNAs with no mRNA matches exhibited a wider length distribution. It is possible that siRNAs without mRNA matches represent a less uniform group suggesting alternative modes of synthesis for these sequences. siRNAs in the library of Ruby and co-workers [6] were enriched for siRNAs with matching mRNAs (Figure 1c) while siRNAs with fewer mRNA matches were more highly represented in the library of Lee and co-workers [5] (Figure 1b). A possible explanation could arise from the characteristics of the cloning method used by the two laboratories. The siRNA-library by Lee and co-workers was constructed using a 5' monophosphate ligation independent cloning manner, while the construction of the library by Ruby and co-workers utilized the linker sequence with bias to detect 5' monophosphate ends of siRNA molecules. The higher proportion of siRNAs with mRNA matches in the library by Ruby and co-workers could be explained through a case where the majority of these sequences captured with the 5' monophosphate arise from secondary siRNA synthesis on the mRNA template. Secondary siRNAs via the exo-RNAi pathway have been shown to prefer a 5' triphosphate end, while primary siRNAs are generally thought to contain 5' monophosphate in the Dicer dependent synthesis [9,12]. However, the 5' monophosphate could also be obtained by the activity of enzymes with ability to remove 5' γ- and β-phosphates such as C. elegans PIR-1 [4]. Another possibility to obtain a 5' monophosphate end would be the removal of the entire 5' nucleotide with the triphosphate [4,6,12]. The existence of abundant 25-mers along with even more abundant 26-mers provides support for this hypothesis. The argonaute-related gene F55C9.3 was chosen to model the distribution of siRNA sequences along the mRNA. A total of 16 unique siRNAs with 1–10 reads each, aligned on the F55C9.3 mRNA fall into two interesting length categories. The length difference between 19- to 20-mers and 24- to 26-mers reflects the existence of two individual classes of siRNAs on the mRNA. It is tempting to speculate that the shorter ones with only one read exhibit members of a class of primary siRNAs and the abundant longer ones with up to ten identical reads as secondary siRNAs synthesized by a RdRP. However, biochemical studies are needed to further characterize these classes of siRNAs.
Since the siRNAs from the two sources available so far have over 2200 candidate target genes in total, we categorized these genes by their Gene Ontologies (Table 1, and additional file 4). An interesting observation was that the lengths of endogenous siRNAs seem to determine the functional characterization of their putative target genes. The matching mRNAs for 22-mer siRNAs were associated with the GO term embryonic development while candidate targets for 23-mers were uniquely associated with post-embryonic development. It has been shown that some endogenous siRNAs and almost all miRNAs exhibit developmentally regulated expression patterns [1,2]. Interestingly, the 24- to 26-mer siRNAs were associated with phosphorus metabolism or protein modification. We hypothesize that the synthesis of these relatively long 25- to 26-mer endo-siRNA molecules could occur by specific RdRP such as RRF-3 and its associated proteins since a large group of phosphorus metabolism linked genes was observed to be over-expressed in rrf-3 mutant worm strains [15]. RRF-3 has shown to be required for the biogenesis of several classes of endogenous secondary siRNAs [4,5]. In addition, the C. elegans argonaute family of RNA binding proteins could exhibit specificity for the length of siRNA and direct silencing of genes associated with specific biological processes such as embryonic development, post-embryonic development, or phosphorus metabolism.
After plotting the starting nucleotide of siRNA sequences against their length, we observed that most siRNAs have G at their 5' end. In addition, sequence frequency graphs showed preference for C at their 3' end. A and U were largely represented along the body of siRNA molecules. A/U frequency might be needed to lower the energy required to remove newly synthesized endo-siRNA molecules and allow the RdRP complex to continue unprimed production of additional secondary siRNA molecules along the template [12,18]. Only short siRNAs of 12 to 16 nt in length exhibited variable 3' nucleotides (A, G or U) suggesting that these are potential degradation products of longer ones.
Target genes for the siRNAs were observed to be more highly conserved between C. elegans and C. briggsae than the genes on average. One explanation is that siRNAs target genes with conserved exons. It is also possible that evolutionary conserved target genes have had time to develop siRNA sequences, for example, to regulate their expression during specific developmental stages. When each target gene was classified by the number of associated siRNAs, it was observed that the target genes with more than three siRNAs tended to be poorly conserved between the two nematode species. This might indicate the accelerated production of secondary siRNAs for young species specific genes.
In order to understand the cellular functions regulated by endogenous siRNAs collected to date from C. elegans, we merged the libraries from two sequencing projects [5,6] containing all publicly available siRNA sequences resulting in a collection of 7136 endo-siRNA sequences. We characterized their length distributions and the relationship of the siRNA length with the function of genes targeted. The endo-siRNA sequences corresponded to functionally different target genes that were dependent upon the siRNA length: 18- to 22-mers match mRNA targets associated with embryonic development, targets of 23-mer siRNAs associate with post-embryonic development and targets corresponding to 24–26-mer siRNAs involve phosphorus metabolism or protein modification. Genes targeted with siRNAs with multiple reads included several poorly characterized argonaute-related genes. We conclude that the function of target genes of endogenous siRNAs appear to vary depending upon their length. These results also provide additional evidence for existence of a number of siRNA biosynthesis mechanisms capable of regulating gene expression associated with specific biological processes.
The siRNA sequences obtained from mixed stage C. elegans populations by high-throughput sequencing technologies were obtained from previously published studies [5,6]. Lists of 7136 siRNA sequences in total were annotated by using the NCBI BLAST server with Wormbase release WS170 nematode RefSeq mRNA database, which contains only high-quality sequences for gene transcripts. The results were filtered to contain only plus/minus hits against the known mRNAs representing the antisense siRNA sequences. The results were obtained as RefSeq mRNA identifiers that were unique to known transcripts.
Length distributions
siRNAs with equal sequence lengths were grouped together and the sequence frequency graphs were generated separately. Nucleotide frequencies of the included siRNAs were created using WebLogo (University of Berkeley, CA, USA). The same process was repeated for the subset of siRNAs that were associated with mRNA sequences.
Functional categories
The enriched functional categories for the siRNAs with different lengths were obtained using David 2.0 web service [19]. The descriptions for the genes that were targets of 8 or more siRNAs were obtained using Biomart together with WB180 genome. In order to study the conservation of the genes coding the putative target mRNAs, the precalculated BLAST expectation (E) values for the observed homologies between the putative target genes in C. elegans, and their orthologs in C. briggsae, were obtained using Wormbase WB180. SPSS version 14 was used in the graphical presentation of the results (SPSS Inc., Chicago, Illinois, USA).
Authors' contributions
SA conceptualized, planned, performed and designed the analysis and wrote the manuscript. LH performed the experiments and participated in writing the manuscript. GW participated in the design of the experiment, management of the project, and writing of the manuscript. MS performed the experiments, wrote the manuscript, and managed the data and submission. All authors read and approved the final manuscript.
We thank Vuokko Aarnio and Merja Lakso with helpful discussions. The Bartel Laboratory and Ambros Laboratory are gratefully acknowledged for making their data available. The Finnish Graduate School of Neurosciences provided funding for SA. The Saastamoinen Foundation provided funding to LH.
Pasquinelli AE, Ruvkun G: Control of developmental timing by microRNAs and their targets.
Annu Rev Cell Dev Biol 2002, 18:495-513. PubMed Abstract | Publisher Full Text
Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D: MicroRNAs and other tiny endogenous RNAs in C. elegans.
Curr Biol 2003, 13:807-818. PubMed Abstract | Publisher Full Text
Chapman EJ, Carrington JC: Specialization and evolution of endogenous small RNA pathways.
Nat Rev Genet 2007, 8:884-96. PubMed Abstract | Publisher Full Text
Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D Jr, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR 3rd, Mello CC: Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Cell 2006, 124:343-54. PubMed Abstract | Publisher Full Text
Lee RC, Hammell CM, Ambros V: Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans.
RNA 2006, 12:589-597. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Ruby J, Jan C, Player C, Axtell M, Lee W, Nusbaum C, Ge H, Bartel D: Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans.
Cell 2006, 6:1193-1207. Publisher Full Text
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
Nature 1998, 391:806-811. PubMed Abstract | Publisher Full Text
Timmons L, Fire A: Specific interference by ingested dsRNA.
Nature 1998, 29;395(6705):854. PubMed Abstract | Publisher Full Text
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.
Nature 2001, 411:494-498. PubMed Abstract | Publisher Full Text
Wilkins C, Dishongh R, Moore SC, Whitt MA, Chow M, Machaca K: RNA interference is an antiviral defence mechanism in Caenorhabditis elegans.
Nature 2005, 436:1044-1047. PubMed Abstract | Publisher Full Text
Sijen T, Fleenor J, Simmer F, Thijssen KL, Parrish S, Timmons L, Plasterk RH, Fire A: On the role of RNA amplification in dsRNA-triggered gene silencing.
Cell 2001, 107:465-76. PubMed Abstract | Publisher Full Text
Pak J, Fire A: Distinct populations of primary and secondary effectors during RNAi in C. elegans.
Science 2007, 315(5809):199-200. PubMed Abstract | Publisher Full Text
Grishok A, Sinskey JL, Sharp PA: Transcriptional silencing of a transgene by RNAi in the soma of C. elegans.
Genes and development 2005, 19:683-696. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Simmer F, Tijsterman M, Parrish S, Koushika SP, Nonet ML, Fire A, Ahringer J, Plasterk RH: Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.
Curr Biol 2002, 12:1317-9. PubMed Abstract | Publisher Full Text
Asikainen S, Storvik M, Lakso M, Wong G: Whole genome microarray analysis of C. elegans rrf-3 and eri-1 mutants.
FEBS Letters 2007, 30;581(26):5050-4. PubMed Abstract | Publisher Full Text
Zhang L, Kasif S, Cantor CR, Broude NE: GC/AT-content spikes as genomic punctuation marks.
Proc Natl Acad Sci USA 2004, 101(48):16855-16860. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Stein LD, Bao Z, Blasiar D, Blumenthal T, Brent MR, Chen N, Chinwalla A, Clarke L, Clee C, Coghlan A, Coulson A, D'Eustachio P, Fitch DHA, Fulton LA, Fulton RE, Griffiths-Jones S, Harris TW, Hillier LW, Kamath R, Kuwabara PE, Mardis ER, Marra MA, Miner TL, Minx P, Mullikin JC, Plumb RW, Rogers J, Schein JE, Sohrmann M, Spieth J, Stajich JE, Wei C, Willey D, Wilson RK, Durbin R, Waterston RH: The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics.
PLoS Biol 2003, 1(2):E45. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Sijen T, Steiner FA, Thijssen KL, Plasterk RH: Secondary siRNAs result from unprimed RNA synthesis and form a distinct class.
Science 2007, 315:244-7. PubMed Abstract | Publisher Full Text
Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA: DAVID: Database for Annotation, Visualization, and Integrated Discovery.
Genome Biology 2003, 4(5):P3. PubMed Abstract | BioMed Central Full Text


text:
Classic Rock Pick Of The Week – Hall Of Fame Rock-N-Roll Inductees [VIDEO]
The Rock-n-Roll Hall of fame inductions are at the Barkleys Center in Brooklyn on Thursday, including Peter Gabriel, Nirvana and Kiss.
Let's honor all three for our Classic Rock Pick of the Week!
Kiss formed in the Big Apple in 1973 with original members, Peter Criss, Paul Stanley, Ace Frehley and Gene Simmons


text:
Is This a Dig at Leo? Bar Refaeli Posts Joke On Twitter: 'Was I Drunk the Entire Relationship?'
Bar Refaeli had a little laugh via Twitter on Monday, but was it at her ex Leonardo DiCaprio's expense?
The supermodel, 26, re-tweeted a joke from her friend Valentina Micchetti that read:
"Have you ever Looked at your ex and thought: "was I drunk the entire relationship"???"Bar added a "Lol" at the end of this message.
Since breaking up this time last year, Bar and Leo have both moved on. Since the split, Leo has been connected with a few other models, Blake Lively and most recently, Victoria's Secret hottie Erin Heatherton.
Bar also had a new beau of her own David Fisher, though it's not confirmed it they're still together. She was also spotted out to dinner this weekend with a mystery male. What do you think? Was this re-tweet directed at Leo? Sound off in the comments!


text:
Gluten-Free Noodle Soup Recipes For Chilly Winter Nights
9 Recipes To Dress Up Your Winter Veggies
Get Mile-Long Looking Legs With This Style
Start on hands and knees with back straight, wrists directly beneath shoulders. Take three counts to simultaneously extend left arm and right leg in line with body (as shown); hold for two counts. Switch sides; repeat for one rep. Do 12 reps.


text:
Having a chronic illness like ME/CFS can make it hard to avoid problems that come from bad ergonomics. Jody Smith has learned some lessons the hard way ...
Discuss the article on the Forums.
Irritable Bowel Syndrome Clearly Linked to Gut Bacteria
Discussion in 'Other Health News and Research' started by Waverunner, May 26, 2012.
Page 2 of 3
Page 2 of 3


text:
0 resultsClear Search
Product Types:
We are primarily a CSA and will list "extras" here - anything that we grow in over-abundance! About Us New Family Farm connects people with good food by growing vegetables for people living in central Iowa. We promote soil health that allows us to grow food that tastes good and nourishes the people who enjoy it. We do this in healthy, biologically-active soil, controlling pests and weeds through pro-active management and gentle natural materials. We are working toward organic certification. New Family Farm is located two miles east of Elkhart on land that has been in the family since 1912. Browse through our Products for Sale Ingredients N/A Practices (our standards for raising or making our products) We follow organic practices. Please inquire if you would like specifics or to discuss growing practices. Additional Information We want to connect people with food, and by doing so increase awareness of broader ecological and social challenges in the world. Highlights this Month N/A |


text:
Local briefs for March 25, 2009
Published: Wednesday, March 25, 2009 at 6:30 a.m.
Last Modified: Wednesday, March 25, 2009 at 1:07 a.m.
Veterans groups to meet this week
The following meetings will be held March 25-31.
Kingdom of the Sun Chapter, Military Officers Association of America, noon, Ocala Shrine Club, 4301 S.E. Maricamp Road, Ocala. (368-6635)
Wall-Rives American Legion, 6 p.m., 10730 U.S. Highway 41, Dunnellon, bingo. (489-4453)
VFW Post 4209, 4 to 7 p.m., 4805 N.E. 36th Ave., Ocala. Fish fry $7. (732-7744)
Amvet Post 19, 4 p.m., 13050 N.E. County Road 316, Fort McCoy, 50s and 60s music. (622-4449)
Amvet Post 19, 5 p.m., 13050 N.E. County Road 316, Fort McCoy, karaoke. (622-4449)
VFW Post 10733, 9 to 11 a.m., 19241 N. US Highway 441, Orange Lake, breakfast $6. (591-4359)
Free OhSO concert tickets for kids
OCALA The Ocala Symphony Orchestra is offering free tickets to local youth for its OhSO Klassical Kids concerts April 4 and April 5, featuring winners of the recent Young Artist Competition. The concerts will be held at Ocala Breeders Sales Auditorium, 1701 S.W. 60th Ave.
Youth organizations, including Boys & Girls Club, Arnette House, Genesis House, Big Brothers Big Sisters, the Ocala Youth Symphony, Kids Central and area public and private schools are welcome. Chaperones are required.
A limited number of tickets are available and reservations must be made by April 1.
For more information, call Dorothy Pitone at 351-1606 or visit www.ocalasymphony.com.
Golf, poker tourney to benefit Hospice
OCALA Hospice of Marion County will hold a Holdem Fore Hospice golf and poker tournament on Saturday, April 4 at Golden Hills and Ocala Poker Room and Jai-Alai. Entry fee is $150 per person and will benefit the patient care program. For more information, call 629-7981.
Heart transplant fund established
OCALA A fund has been established for 15-year-old Forest High School ninth grader Marinna Shyrigh, who is in need of a heart transplant. Marinna has had heart and pulmonary conditions from birth that cause lessened oxygen supply to the body.
At level A-2, she must stay within two hours of Shands at the University of Florida should a donor heart become available.
Donations can be made at any Wachovia Bank to the Marinna Shyrigh Assistance account.
Water conservation a key topic in April
OCALA The State of Florida, Water Management Districts and Marion County Board of County Commissioners are working to increase awareness about water conservation during April Floridas Water Conservation Month.
The Marion County Extension Service has a program called Florida Yards & Neighborhoods that can help residents transform yards as they learn to conserve water resources and reduce pollution. For more information, call 671-8400.
Happening Today
mZuri performs: The Central Florida Community College Citrus Campus Student Activities Board will host mZuri in a portrayal of Fannie Lou Hamer in honor of Womens History Month from noon to 1:30 p.m. at 3800 S. Lecanto Highway, Lecanto. The event is free. For more information, call Adam Hayashi at 746-6721, ext. 6134.
Friendship Tea Time: The Dunnellon Christian Womens Clubs monthly breakfast is at 10 a.m. today at the Rainbow Springs Country Club, 19330 S.W. 83rd Place Road, Dunnellon. Cost is $9.50. For reservations, call Dot Satterwhite at 465-6153.
Book Sale: Friends of Freedom Public Library will hold their spring book sale from 10 a.m. to 6 p.m. Thursday and Friday and 10 a.m. to 1 p.m. Saturday at 5870 SW 95th St. Books, videos, CDs and puzzles will be available. Proceeds benefit the library. For information, call 861-0353.
Rummage Sale: A Habitat for Humanity rummage sale will be held from 8 a.m. to 1 p.m. Friday and Saturday at St. John Lutheran Church, 10495 Sunset Harbor Road, Summerfield. For more information, call 288-2041.
Antique Show: A Sawgrass Antique Show will be held from 9 a.m. to 5 p.m. Friday through Sunday at A Antique Mall, 17990 N.W. 77th Ave., Reddick. Admission and antique appraisals are free. For more information, call 591-3120 or email@example.com.
Walk MS: The Mid Florida Chapter, Walk MS, will hold 3K and 5K walks from 8 a.m. to noon Saturday at The Villages Polo Field, 1100 Main St., Lady Lake. For more information, call 888-950-9080 or visit, www.midfloridamswalks.org.
Green Thumb Plant Show: The second annual Green Thumb Plant Show will run from 9 a.m. to 4 p.m. Saturday on Pennsylvania Ave., Dunnellon. For more information, call 465-1460 or visit grumbleshouseantiques.com.
Motorcycle run: A motorcycle run to benefit the VFW Retirement Home begins with registration at 8 a.m. and ride at 9 a.m. Saturday at 4805 N.E. 36th Ave., Ocala. Tickets are $10 per person. For more information, call David Dale at 425-1095.
Cracker Village tour: Take a guided tour through the replica Cracker Village at 3 p.m. Saturday at Silver River State Park, 1425 N.E. 58th Ave., Ocala. Admission is $4 per car. For more information, call 236-7148.
Curious George visits the library: The Marion County Public Library is hosting Curious George at 2 p.m. Saturday at 2720 E. Silver Springs Blvd., Ocala. For more information, call 368-4515.
Expo: The annual Hands Are Not For Hurting Expo will be held from 10 a.m. to 2 p.m. Saturday at Paddock Mall, 3100 S.W. College Road, Ocala. The free event features entertainment, children performances, arts and crafts. For more information, call 438-5993.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
Comments are currently unavailable on this article


text:
- Conservatives join New Hampshire rally in support of campaign finance reform
- 11 public housing residents complete job readiness training
- Youth health care enrollment event at NIU Rockford Jan. 29
- More than 50 employers at Jan. 29 job fair
- School district's credit rating remains solid
- State Police seize LSD, cannabis, U.S. currency in I-80 arrest
- Park District names employee, team of the year
- A closer look at fracking for natural gas
- Susan Johnson, copy editor, moves on after 21 years
- Guest Column: Clean Water Act: Supporters of clean water must make their voices heard
Spring ice show at Carlson Ice Arena May 5
Staff Report
Rockford Park District's Carlson Ice Arena will host its spring ice show, "Skating Down Abbey Road," featuring hit music by The Beatles Saturday, May 5. Show times are 1 and 7 p.m.
Approximately 100 local skaters of all ages and levels from Rockford Park District Learn to Skate and Figure Skating programs will demonstrate their skills in performances featuring hit music by The Beatles. The 1 p.m. show will also feature special guest Kyle Shropshire, 2012 U.S. National Junior Competitor.
Ticket prices are general admission, $7 in advance, $8 day of show. Golden Admission tickets (includes both shows) are $10 in advance (not available at the door); admission is free for children ages 2 and younger. Tickets are on sale at Carlson Ice Arena at Riverside and Perryville in Loves Park, and at Park District Customer Service in downtown Rockford, 401 S. Main St.
For more information, visit www.rockfordparkdistrict.org/iceskate, or call (815) 969-4069. For information about accessibility and assisted listening equipment for people with disabilities, call (815) 987-8800.
From the May 2-8, 2012, issue


text:
Im I the only 1?
Comments (9)
Caleigh, Mom to Brody James 4/18/10
Madeleine Rose 1/28/13
A+C since 1/19/07
Angel baby 11/16/07 Rainbow Baby 4/03/09 (DS)
Pink Miracle due 2/14/13
I'm the same. I dont remember them being sensitive this long with any of my other 3 pregnancies. I have to wear a bra all the time because I cant even handle a shirt touching them. It sucks
Riley 3-2004 Kennedy 3-2006 Sawyer 4-2010
Baby Boy due 1-29-13
Definitely not. Mine are so sensitive, I don't even let DH touch them. My boos themselves are fair game, just not my nipples. I didn't really like them being touched/licked before pregnancy though either (sorry if TMI).
Married the man of my dreams 3/18/11
Welcomed our little love bug on 2/14/13!
EBF (.Y.) GOLD!!! 14 months!
i wont let my man near mine right now. every time they get hard (TMI) they hurt like hell


text:
Navigate the solar system with your spaceship. Land on or push any planet. Gameplay campaigns for humanitarian or destructive ends are in the works, so check back.
No news were found matching the criteria specified. We suggest you try the news list with no filter applied, to browse all available articles. Join now to share news with the community.