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Please help.. I have a child that likes to visit the local park and play on the swing but, the only problem is that I notice... more
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Featured Neighborhoods in New Castle, DE
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- Barb's Farm Community
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- Colwyck Elementary School
- (302) 429-4085
- 12 Landers Lane
- New Castle, DE 19720
- Eisenberg (Harry O.) Elementary School
- (302) 429-4073
- 28 Landers Lane
- New Castle, DE 19720
Middle Schools
- New Castle Middle School
- (302) 323-2880
- 903 Delaware Street
- New Castle, DE 19720
- Bedford (Gunning) Middle School
- (302) 832-6280
- 801 Cox Neck Road
- New Castle, DE 19720
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- Multiple Alternative Program
- (302) 322-1718
- 626 Wilmington Road
- New Castle, DE 19720
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- (302) 323-2800
- 713 East Basin Road
- New Castle, DE 19720
Sex Offender Information for New Castle, DE
For most citizens, the easiest method to obtain accurate and timely sex offender information for their local area is to visit their state sex offender registry website. States are required to provide this information for free. You do not need to pay for this information.
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Map of New Castle, DE
Cities and towns near New Castle, DE
- Arden
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- Bear
- Beckett
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- Carneys Point
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- Edgemoor
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- Elsmere
- Glasgow
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- Hockessin
- Lower Chichester
- Mannington
- Newark
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- North Star
- Oldmans
- Penns Grove
- Pennsville
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- Pike Creek
- Salem
- Wilmington
- Wilmington Manor


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All of the recipes on this page are gluten free, and most can be made dairy free. To get recipes and tips in your inbox, subscribe to The Gluten-Free Homemaker.
Trying to find gf brownie recipe from you using gf chocolate cake mix.
Sorry, I don't have one. Most of my recipes are from scratch. A few older ones use a gf flour mix, but I don't think I have anything that uses a cake mix. Definitely not brownies.

subset: commoncrawl


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BOISE, Idaho -- People who buy kosher foods and consumers of natural and organic products are overlapping groups, a trend retailers are recognizing in their merchandising approaches. Albertsons here is piloting a new merchandising program at a Jewel-banner store in Evanston, Ill., in which its Wild Harvest natural/organic department is positioned next to its kosher department. "We've seen tremendous crossover," said Yakov Yarmove, the retailer's ethnic category manager. Likewise, Giant ...
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New Revised Standard (NRS) | New International Version (NIV) |
15 If anyone stirs up strife, it is not from me; whoever stirs up strife with you shall fall because of you. | 15 If anyone does attack you, it will not be my doing; whoever attacks you will surrender to you. |
New Revised Standard Version Bible, copyright 1989, Division of Christian Education of the National Council of the Churches of Christ in the United States of America. Used by permission. All rights reserved. (New Revised Standard Bible Version Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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The Most Romantic Hotels In Napa
Enhance a romantic getaway by staying at one of the most romantic hotels in the Napa Valley area.
Oakland Named by 'Traveler' Mag as Second Unfriendliest City in U.S. (Again)
Live 105 reports…Sticks and stones…
Bay Area August Events Not To Be Missed
The sun is out & summer is in full swing. With this list of August events, we're sure there's something to do for everyone!
StarDate: The Brick
The center of the Milky Way is already crowded with stars. But in a few million years, tens of thousands more could flare to life in a region known as the Brick. It's a vast cloud of cold, dark gas and dust that's shaped like a brick.
Travel Guide For Martha's Vineyard
Refer to this travel guide for the best dining, lodging and attractions on Martha's Vineyard.
StarDate: 'New' Stars
At Christmas of 1934, a bright "new" star exploded to life in Hercules. For a few days, it was one of the brightest stars in the night sky. It made the front pages of newspapers, and astronomers tracked it for months as it slowly faded from sight.
Best Sunvalley Shopping Center Stores For Outdoor Adventurers
Outdoor adventurers can equip themselves nicely at stores within the Sunvalley Shopping Center. From staying in shape and wearing the right sports apparel to taking it all in with the best backpack around, it's all there.
StarDate: Venus and Mercury
Mercury and Venus, the Sun's closest planets, team up in the eastern sky at dawn the next few mornings. Venus is the "morning star," so it's an easy target. Mercury is fainter, but it's not far to the lower left of Venus, which will help you pick it out.
Best Biking Trails Of Mount Diablo
Mount Diablo has a top reputation as the best place for East Bay mountain biking. With varied terrain and numerous trails, Diablo biking is best suited to strong intermediate cyclists.
Bay Area July Events Not To Be Missed
The sun is out & summer is in full swing. With this list of July events, we're sure there's something to do for everyone!


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Popular Chess Terms
Petrosian and Spassky
The battle for the World Chess Championship has witnessed numerous titanic struggles which have engaged the interest not only of the chess enthusiasts but of the public at large. The chessboard is the ultimate mental battleground and the world champions themselves are supreme intellectual gladiators.
This magnificent compilation of play from the 1960s through to the 1970s forms the basis of the third part of Garry Kasparov's long-awaited definitive history of the World Chess Championship. Garry Kasparov, who is universally acclaimed as the greatest chessplayer ever, subjects the play from this era to a rigorous analysis, the examination being enhanced by the use of the latest chess software.
Garry Kasparov on My Great Predecessors - VOLUME III
This book brings together the two greatest names in the history of chess. The author, Garry Kasparov, is the world number one and, by common consent, the greatest player ever. The subject of the book, Bobby Fischer, is the only American to have become world champion and is probably the greatest natural talent the world has ever seen.
Garry Kasparov on My Great Predecessors - VOLUME IV
Korchoi and Karpov
This book, the fifth in Garry Kasparov's magnificent history of the World Chess Championship, catalogues the "post-Fischer" period in the 1970's and early 1980's. This period was dominated by Anatoly Karpov (world champion from 1975-1985) and his three-time challenger, Viktor Korchnoi. Anatoly Karpov gained the right to challenge Bobby Fischer for the world title by winning through the Candidates series in 1974. As is well known, Fischer refused to defend the title and in 1975 Karpov became champion by default. Although he did not have to contest a Championship match to gain the title, Karpov proved that he was a worthy champion by winning virtually every major tournament over the next decade.
Garry Kasparov on My Great Predecessors - VOLUME V
Do you instinctively know what to do in every type of chess position or are you often uncertain about how to proceed? Wouldn't it be really useful to know the best chess strategies and to recognise when they should be used? In this book Sam Collins examines key games from both the classical and modern eras. He analyses the major strategic ideas that have stood the test of time and notes their considerable influence on his own games.
Greatest Ever Chess Strategies
There is no easier way to win a game of chess than by luring your opponent into a devious trap. Similarly, there's nothing worse than being the one on the receiving end. Tricks, traps and swindles lie in wait everywhere, especially so in the opening phase of the game, and many battles can be won or saved simply through learning and mastering the most important ones. In this instructive and fun book, Gary Lane looks back through chess history and at modern times to create a list of his own favourite tricks and traps.
Greatest Ever Chess Tricks and Traps
Chess enthusiasts can find out where they stand in terms of chess mastery by facing off against 20 of the world's top players with this instructive and amusing guide. Looking closely at complete games played by the experts inspires players to form new ideas about their overall strategy. Grandmaster Daniel King based "How Good Is Your Chess" on his popular Chess Monthly column.
How Good Is Your Chess?
100 games analyzed simply and clearly, showing exactly how Karpov won. Over 300 chess diagrams.
How Karpov Wins - 2nd Edition
Emphasis throughout the book is on understanding principles, rather than memorizing moves, with the result that the reader will be able to apply Znosko-Borovsky's techniques to almost any situation that may arise.
How to Play Chess Endings
Mistakes are often made in the early part of the game - at all levels of chess - but a key skill is to recognize these critical moments as they happen and to exploit them with maximum efficiency. This is a skill which Grandmaster Simon Williams addresses in this book. Using instructive and entertaining games in which one side wins quickly, he examines all the typical mistakes chess players make in the opening and early middlegame, how you should look to exploit them, and how to avoid falling into similar traps yourself.
75% Off Books (Shown in Cart)
How to win at Chess - Quickly
In August 2008 Andres D. Hortillosa entered the New England Masters. It was a brave choice for an unrated player to compete in such a tough event, but it proved to be an inspired decision; he exceeded all expectations and was rewarded with a FIDE international rating of 2199. This, however, was no overnight success; it was the result of systematic work. How did he achieve such outstanding improvement? The answer lies in this book.
75% Off Books (Shown in Cart)
Improve Your Chess At Any Age
One of the best ways to improve is to study the games of a top Grandmaster, and Ivan Sokolov's uncompromising style and tactical flair make him a perfect role model. In this book Sokolov demonstrates the deadly effectiveness of his systems against openings such as the Nimzo-Indian, Queen's Gambit, Slav, and King's Indian.
Ivan Sokolov's Best Games
Viktor Korchnoi is a chess legend. In a career which has spanned over 60 years, he won countless grandmaster tournaments, was a four-time Soviet Champion, a multi-time World Championship Candidate, and twice fought for the World Championship in famous battles with his adversary Anatoly Karpov.
Korchnoi - Move by Move
Vladimir Kramnik is a giant of the chess world. He firmly secured his legendary status when he won the World Championship in 2000 by defeating the previously dominant Garry Kasparov - the only player ever to do so in a match. Kramnik held on to his crown for seven years, and today he remains one of the World's elite players. In this book, former American Open Champion Cyrus Lakdawala invites you to join him in a study of his favourite Kramnik games.
Kramnik - Move by Move
In this book, former American Open Champion Cyrus Lakdawala studies his favourite Larsen games and examines Larsen's skills in the key areas of attack and defence, initiative, exploiting imbalances, accumulating advantages and endgame play.
Larsen - Move by Move
Lasker's Manual of Chess is one of the greatest chess books ever written. The fact that it was first published over 80 years ago has diminished neither its relevance nor significance in today's modern chess world. Lasker was both a wonderful fighter and a deep thinker; his book is the quintessence of the exceptionally successful experiences he had over many long years, and his thoughts about them.
Lasker's Manual of Chess
A Complete Course
Learn Chess: A Complete Course provides everything you need to know to get started in chess. The first part is devoted to first principles, explaining the rules and basic strategies, whilst the second develops a thorough understanding of the various winning methods, and includes a systematic study of openings, an introduction to attacking techniques, and a guide to fundamental endgame themes.
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Learn Chess
Enhance Your Chess Strategy and Psychology with Boris Gulko
Club players are unaware of the subtleties that exist in grandmaster chess. Grandmasters can analyse chess at a depth that is unfathomable to amateurs. Moreover, they have extensive knowledge of chess history and opening theory, as well extraordinary endgame technique and tactical vision. However, having reached such a high level can make it difficult to understand what is lacking in the mind of the amateur.
Lessons with a Grandmaster
Improve Your Tactical Vision and Dynamic Play with Boris Gulko
This book is the much anticipated follow-up to the highly acclaimed and award-nominated Lessons with a Grandmaster.
Lessons with a Grandmaster II
Mikhail Tal, the "Magician from Riga", was the greatest attacking World Champion of them all, and this enchanting autobiography chronicles his extraordinary career with charm and humor. Dazzling games are interspersed throughout with anecdotes and witty self-interviews, and in typically objective fashion he relates both the ups and downs of his encounters.
Life and Games of Mikhail Tal
How Carlsen Beat Kasparov's Record
What is Magnus Carlsen's secret? How did an already world-class player succeed in reaching this unprecedented level where he was regularly beating the world's strongest grandmasters? In this book, International Master Colin Crouch provides answers to these questions. Crouch studies Carlsen's progress in recent years and demonstrates how he learned lessons from previous setbacks, turned weaknesses into strengths, losses into draws, and draws into wins. By doing so Carlsen was able to elevate his play to a stratospheric level, but any aspiring chess player can use similar methods to improve their game.
Magnus Force
Short Description for Mastering Chess Strategy - B0310EM
Mastering Chess Strategy
Following his highly acclaimed Mastering Chess Strategy and Mastering Opening Strategy, this book completes a trilogy of strategy books by Grandmaster and renowned chess teacher Johan Hellsten. In his new work Hellsten focuses exclusively on endgame play and covers every type of endgame: pawn, minor piece, rook and queen endgames. He examines not only the many fundamental positions that everyone needs to know, but also the key themes and characteristics of successful endgame play, including activity, creating and exploiting weaknesses, active and passive defence, fortresses and technique
Mastering Endgame Strategy
The games of Mikhail Botvinnik, world chess champion from 1948 to 1963, have been studied by players around the world for decades. But little has been written about Botvinnik himself. This book explores his unusual dual career--as a highly regarded scientist as well as the first truly professional chess player--as well as his complex relations with Soviet leaders, including Josef Stalin, his bitter rivalries, and his doomed effort to create the perfect chess-playing computer program. The book has more than 85 games, 127 diagrams, twelve photographs, a chronology of his life and career, a bibliography, an index of openings, an index of opponents, and a general index.
Mikhail Botvinnik - The Life and Games of a World Chess Champion
Did you ever notice how some famous GM games are more interesting to play through than others? For instance, tell me you have a Tartakower or Nimzowitsch game and I'm sorry, but I just can't get that excited. But tell me you have a Fischer, Alekhine, or Tal game you want to show me and woo-hoo!, break out the milk and cookies because I know I'm in for a real treat! And Mikhail Tal: Tactical Genius by Alexander Raetsky and Maxim Chetverik is loaded with enough tasty treats to satisfy the most demanding of palates.
Mikhail Tal - Tactical Genius
A Step-By-Step Guide to Brilliant Chess
Leading chess author Colin Crouch selects and explains over 30 sensational games, all from the new millennium. By studying battles between the world's best players, Crouch examines in detail all the key areas of modern chess
Modern Chess - Move by Move
A thorough analysis of Chess Games by the greatest player of all time, Paul Morphy. It features 54 against such masters as Anderssen, Harrwitz, Mongredien, Bird, Paulsen and others; 52 of the best blindfold games; 52 games at odds; and 142 in consultation, informally, etc. Detailed annotations of games by such expert analysts as Sergeant, Steinitz, Anderssen and Morphy himself.
Morphy's Games of Chess
This book, about the best chess player of the nineteenth century, analyzes Paul Morphy's games and positions in depth to reveal the essence of his style. The first collection in English of all 413 of Morphy's known games, the volume discusses other players of the period (Adolph Anderssen and Wilhelm Steinitz), Morphy's rare blunders and omissions, as well as selected endgames and openings.
Paul Morphy and the Evolution of Chess Theory
Winning at Chess the Adventurous Way
It was the chess legend Philidor who wrote: "The pawns are the soul of chess", and yet it is these modest infantrymen who are always the first to die for the cause. Pawn sacrifices are incredibly common in chess games, and yet for some unknown reason they have been rather neglected in chess literature... until now.
75% Off Books (Shown in Cart)
Pawn Sacrifice
Tigran Petrosian was a World Chess Champion and a true legend of the game. He was nicknamed "Iron Tigran" because of his incredible defensive skills that made him a formidable opponent who was virtually impossible to defeat. Petrosian was the master of restraint, prophylaxis and prevention. He could spot and defuse threats well before they were created, suck the life out an opponent's position and then seize a vice-like grip on the game. In this book, International Master Thomas Engqvist selects and examines his favourite Petrosian games, and shows us how we can all learn and improve our chess by studying Petrosian's masterpieces.
Petrosian - Move by Move
In this book the reader will discover the incredible power unconventional moves can have. These moves contradict the most fundamental principles of the "old chess", and yet most of them played by leading grandmasters.
Play Unconventional Chess and Win
An Introduction to the Moves, Strategies, and Philosophy of Chess from one of the World's Top Chess Players
'When most people learn to play chess, they usually memorize the movements of the pieces and then spend years pummeling away at each other with little rhyme and even less reason. Though I will show you how each piece leaps around, what it likes to do on holidays, the real purpose of this book is to teach you to understand the four major principles of my Seirawan method: force, time, space and pawn structure. Each is easy to understand and each is a weapon that will enable you to defeat most anyone you challenge to a game' -Yasser Seirawan
Play Winning Chess
495 Instructive Positions from Grandmaster Games
This complete guide, written by a grandmaster, can assist all players at every level in developing a more powerful strategic game. Spanning more than a century of chess, it presents examples on such themes as key squares, bad bishops, and pawn structures in ascending difficulty, with ample cross-references.
Positional Chess Handbook
The Definitive Guide to the Endgames that Really Matter
The Definitive Guide to the Endgames that Really Matter!
Welcome to a new type of endgame book. A book that includes...
The most common endgames you will ever encounter.
Examinations of material balances you will reach in almost half of your games.
Over 500 pages of grandmaster advice and analysis, assisted by the latest computer software.
Practical Endgame Play - Beyond the Basics
By addressing important practical aspects of the endgame in lively fashion, Mednis draws the reader into exploring the endgame in a painless and captivating manner. Here at last is an endgame book designed to be read from cover to cover!
Practical Endgame Tips
There's no escaping the fact: if you want to win chess games, you have to attack at some point. Many players are happy solving combinations in winning positions, when the hard work is already done, but the key to a successful attack undoubtedly comes much earlier. No-one can attack effectively if they haven't prepared properly, and yet planning in chess can be a difficult technique to master, even for experienced players.
Prepare to Attack
Endgame-Winning Moves, Strategies and Philosophy from One of the World's Best Chess Players
Random Shopworn Books These are books that are shopworn, but we only have one or two of. All of them are great books by lengendary authors, and all can be yours for a signifigantly reduced price! When you buy a random shopworn book, we cannot guranteea specific book selection. Please take this into consideration when purchasing. Books pictured are a sampling of the books available.
Random Shopworn Book!


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A new line of golf clubs from Nike is hitting the links without support from its one-time spokesman, superstar Tiger Woods. The "Victory Red" clubs get their name from Woods' habit of donning a red jersey on the final day of tournaments, but the marketing plan features golf pro Lucas Glover.
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The Grachan Moncur biography is missing.
Add it now.
Extended Analysis
More articles about Grachan Moncur
July 03, 2008
Grachan Moncur III: "Jammin' on the Hudson"
June 27, 2008Grachan Moncur III: Jammin' on the Hudson
March 23, 2006Grachan Moncur Band April 8-9 at the Iridium Jazz Club
January 07, 2003


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Ken Rosenthal
FOXSports.com Senior MLB Writer
Ken Rosenthal has been the FOXSports.com's Senior MLB Writer since August 2005. He appears weekly on MLB on FOX, FOX Sports Radio and MLB Network. He's a member of the Baseball Writers Association of America. Follow him on Twitter.
LATEST FROM Ken Rosenthal
Dodgers, Mattingly agree to three-year deal through 2016Los Angeles Dodgers and manager Don Mattingly have agreed to a new three-year deal that will take him through the 2016 season, a source confirmed on Tuesday.
Rosenthal: Dissecting the many dilemmas for the DodgersHow odd that the most expensive team in the majors also faces more unresolved issues than any other. But as we begin 2014, such is the state of the Los Angeles Dodgers.
Rosenthal: Now's best time for Angels to add payroll, pay luxury taxMessage to Los Angeles Angels owner Arte Moreno: You're eventually going to blow past the $189 million luxury-tax threshold. So, you might as well start this offseason.
Rosenthal: MLB, Yankees might be asking themselves same questionYankees' quest to get under $189 million in payroll, MLB's case against A-Rod have something in common.
Rosenthal: Analyzing and justifying my Hall of Fame ballot
I've always been flexible with my Hall of Fame ballot, adjusting as warranted. This year, I'm making two significant changes, the first because one of my old methods was ill-conceived, the second because certain exclusions were necessary due to the much-discussed crowded ballot.
Rosenthal: Rangers may be lefty-heavy now, but they're still stackedIf you want to nitpick the Rangers after their seven-year, $130 million agreement with free-agent outfielder Shin-Soo Choo, you can argue that they lack right-handed power.
Rosenthal: Is Seattle suddenly pinching pennies? If so, M-barrassing!If the Mariners are done spending then the only thing that can be said about their plan is that there was no plan at all.


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Department News
Reilly French Scholarship
Deadline December 12, 2014
Coming Up
The 4th Undergraduate Conference on Hispanic Linguistics (UCHL)
November 24th - Schulz Library 3001 December 1st - Stevenson Redwood Lounge, 1st Floor
Global Learning Experience for Freshmen
Our department offers a Freshman Learning Community in Humanities that focuses on International Education. The Global Learning Experience (MLL 161A/B) provides important GE units toward graduation, the ability to learn another language and, if desired, preparation for Study Abroad.
NEW ITDS Special Major: "German Cultural Studies"
The German Program is now offering a Special Major through ITDS in German Cultural Studies. Click here for more information.
The programs and courses of the Department of Modern Languages and Literatures make accessible to students the languages, literatures, and cultures of France and the Francophone world, Germany and other German-speaking countries in Europe, and Spain and Latin America.* * * * * * * * * * *
Félicitations! Herzlichen glückwunsch! ¡Felicidades!
On behalf of the faculty of the Department of Modern Languages and Literatures, I would like to thank our majors and minors for another successful academic year. I would especially like to congratulate our graduating seniors! We wish you well in your future endeavors.- Christine Renaudin, Chair, Modern Languages & Literatures


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WE ARE GETTING READY FOR spring growing 2014
please gave us a call for more details 352-789-5143
we will have starter plants avail in 1 month call or email for more infro
Season: May through December
Type: single farm
Since: 2009
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1/2 Share: 15.00 a month for 12 week min
Work Req? No
orkra and peppers
we deliver to the wholsalers
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U.S. lawmakers and officials said Sunday they expect both sides of the Israeli-Palestinian conflict to seek justice after a spate of back-and-forth violence that began with the kidnapping and murder of three Israeli teens last week.
Since then, violence has erupted on both sides and a Palestinian youth has been killed, potentially as revenge amid the widespread belief the extremist Hamas group is responsible for the trio's deaths.
"In both instances, we have to condemn acts of violence in the strong possible terms," Sen. Robert P. Casey Jr., Pennsylvania Democrat, told Fox News Sunday.
He said the Israelis appear committed to holding criminals responsible.
"I would hope and expect the Palestinians would do the same thing, but that remains to be seen," he said.
Ron Dermer, Israel's ambassador to the United States, said Israelis will not hold up their perpetrators as heroes, which the other side has been known to do.
"That's the difference between our societies and it's a difference we should never forget," he told Fox.
© Copyright 2015 The Washington Times, LLC. Click here for reprint permission.


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On the mend: Continuing healthcare reform laws will heighten demand for industry services
IBISWorld's Primary Care Doctors market research report offers insightful industry analysis and research into the market at the national level. IBISWorld's in-depth industry market research is presented in a logical and consistent format. The industry report contains key industry statistics, market size, industry trends, and growth and profit forecasts for a 5-year outlook period.
The Primary Care Doctors industry is an integral component of United States healthcare. However, the recession forced many consumers to cut back on doctor visits and restricted health insurance access to an increasing number of unemployed individuals. However, the main factor contributing to fewer visits was a decrease in the number of people with private health insurance, especially in 2009. Nevertheless, the industry is projected to benefit from the healthcare reform laws of 2010 and revenue will increase in the five years to 2019. As more individuals gain health insurance due to the reform, demand for primary care services will increase, growing industry revenue in turn... purchase to read more
Barriers to entry in this industry are at a moderate level. It is not expensive to establish a practice in the industry, as evidenced by the large number of small establishments. In addition, there are limited benefits to scale economies (i.e. being a large practice) in this industry; therefore, new entrants are not significantly burdened by their cost structure in the early stages of developing the practice and do not have to compete with firms that dominate the industry.
However, there are educational and regulatory barriers. An individual who wants to become a primary care physician must complete lengthy and expensive educational requirements, internships and residencies... purchase to read more
This industry comprises general practitioners that possess a Doctor of Medicine (MD) or Doctor of Osteopathy (DO) degree. These doctors primarily work using a broad understanding of all illnesses and do not restrict their practice to one particular field of medicine. Doctors in this industry are trained for comprehensive first-contact and continued care for individuals with any undiagnosed health concern.
Industry Definition Main Activities Similar Industries Additional Resources
Executive Summary Key External Drivers Current Performance Industry Outlook Industry Life Cycle
Supply Chain Products & Services Major Markets
Business Locations Competitive Landscape Market Share Concentration Key Success Factors Cost Structure Benchmarks Barriers to Entry
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I stayed at Hotel Hojarascas for a week while I was studying Spanish at the Intercultura School. The hotel is family owned and operated and it doesn't take long for one to feel right at home. Omar, one of the owners and an accomplished cook in his own right, prepares a different Costa Rican specialty every morning (the hotel offers... More
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Hi peeps Looking to take some decent photoes of my motor and give them a little extra kick with photoshop, just basics brushing etc and any other tips and tricks that you guys use but when i look about i all people making their car look completely different and no real help on how to do suttle stuff to your car but keep it looking the same. Can anyone post and useful links or comment to help me. Much appreciated Scott
hi, a neat trick i found was hdr, shoot in raw with your camera and open the raw file with bridge, then choose photoshop from the bridge, and then HDR, then play around with the sliders, if thats a bit much for you, try youtube for (no joke these are a good tutorial and how I learnt) "you suck at photoshop" they are funny and a cool way of learning!! gradients are always fun too, trying putting a gradient on a new layer and changing the blend mode above your layers pallette! hope this helps!
just spend time playing with photoshop, i'm a designer and still learning new tricks.... there are many plugins available. but with the more you have the more confused you will get. practice makes perfect.
Really good pics of your car. I have observed the main quality of your car and the quality is the design and color of your car. This is very attracting and in among the peoples.


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I hope that someone out there is still working on this family and can give me some clues. I am trying to help a friend find the parents of her 4th gr. grandfather, Gideon Sands. The census information for his children in Ripley county, Indiana suggest that he was born in Virginia. He died in 1838 and is on the 1830 census in Ripley Co. We also find a Gideon Sands on the 1820 Census in Hamilton Co., Ohio. His children were born in Ohio, Pennsylvania and Kentucky but I realize we can't always trust those birth states listed on the census. His first child was born 1790 which makes me think he was probably born in the 1770 time period. Since finding the record about Sarah Sands, who had been disowned by the Quakers for having a son born out of wedlock, and seeing the of Edmund in Virgina who names a grandson, Gideon Sands the son of his daughter Sarah, I think there is a possiblity I am looking at the same person. The problem is that I can find nothing to prove anything - it is all conjecture! Is anyone out there who knows anything about the Gideon who ended up in Ripley Co., Indiana and his ancestors? Notify Administrator about this message?
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Showing blog posts tagged with Astrophysics
StarTalk Radio is an iTunes Best of 2014 Pick
by AMNH on
Hayden Planetarium Neil deGrasse Tyson's StarTalk Radio gets the nod from Apple for this year's top podcasts.
Frontiers Lecture: The Copernicus Complex with Caleb Scharf
by AMNH on
In this lecture, astrophysicist Caleb Scharf, author of The Copernicus Complex, takes us on a cosmic adventure like no other, from tiny microbes within the Earth to distant exoplanets and beyond.
Frontiers Lecture: The Universe and Beyond
by AMNH on
Cosmologist Alexander Vilenkin discusses new research suggesting that the Big Bang was not unique in the cosmic history.
Podcast: Frontiers in Astrophysics–Tracking Asteroids with Richard Binzel
by AMNH on
Space dust and asteroid fragments reach Earth's surface every day, but only rarely do extraterrestrial objects cause serious harm. In this podcast from the spring, MIT professor Richard Binzel evaluates the threat of asteroids and makes a case for how they might actually be useful to humans.
Dr. Binzel's talk, "Tracking Asteroids," from the Frontiers in Astrophysics lecture series, took place at the Hayden Planetarium on April 16, 2012.


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Editorial: Time To Take Action, Quit Smoking Jan 22 2015 - 5:06amCommentsIn 1964, the surgeon general published its first report on smoking and health.
Editorial: MLK Events Teach Valuable Lessons Jan 18 2015 - 5:08amComments On Aug. 28, 1963, Dr. Martin Luther King Jr. delivered his famous speech stating he had a dream that one day our nation, "will rise up and live out the true meaning of its creed: 'We hold these truth to be self-evident; that all men are created equal.'"
Editorial: Adult Education Changes Everything Jan 12 2015 - 4:05amComments As January is the traditional time for new beginnings and self-improvement goals, the timing couldn't be better for Arkansas' Adult Education's statewide campaign to draw attention to the number of Arkansans without a high school diploma and to the great opportunities they have to improve their circumstances.
Editorial: Taxpayers Have to Face Today's Bills And Tomorrow's Challenges Jan 11 2015 - 4:06amComments Let's face it: Sewers aren't sexy. Nobody, except some professionals we suppose, likes talking about them. Absolutely nobody likes paying for them.
Editorial: Still Time To Get On The Arc Dec 21 2014 - 4:35amComments We hope you've been as interested in the stories about The Arc for the River Valley as we've been.
Editorial: Park Still Source Of Controversy Dec 14 2014 - 4:35amComments So what does a land-locked city call its water park? And who's going to go there at that price anyway?
Editorial: Visit Humane Society Before Buying Pets Dec 13 2014 - 4:35amComments Recently, we came across an Internet list that seemed useful, which in itself was so remarkable as to merit an editorial. Given the season, it seemed especially germane.
Editorial: Participate In Annual Christmas Honors Dec 12 2014 - 4:35amComments It is unique to Fort Smith, this December tradition of placing an evergreen wreath on every headstone in the National Cemetery, one that brings a tear to the eye and a lump to the throat every year.
Editorial: Holiday Can Trigger Anxiety, Depression Dec 7 2014 - 4:07amComments It's the most wonderful time of the year. Isn't it?
Editorial: Season Offers Plenty of Light Dec 1 2014 - 4:35amComments The search for light in the winter is as old as humanity. When the days grow short and air bites cold, we seek not just the warmth of fire, but its brightness as well. Fires in caves and fires in kivas for prehistoric humans were replaced with gas lamps on the streets of London and burning candles on the tips of Christmas trees in Victorian England.
Editorial: As World AIDS Day Approaches, Optimism Meets Hard Work To End Epidemic Nov 30 2014 - 4:05amComments As World AIDS day approaches, we are reminded that the pace of new infections remains too high, and although treatments have made living with the disease easier, there still is no cure for AIDS or the HIV that causes it.
Editorial: Christmas Card Series To Benefit The Arc For The River Valley Nov 27 2014 - 4:35amComments Greetings to you this fine Thanksgiving morning! May your table be groaning, your home full of love and your heart full of gratitude.
Editorial: Think Before You Shop, Spend And Give Nov 23 2014 - 4:35amComments Despite our best attempts to keep Christmas madness corralled until after Thanksgiving, it arrives even earlier this year than last, which was earlier than the year before.
Editorial: New Congress Has Great Opportunity Nov 21 2014 - 4:35amComments It doesn't matter how one's candidate fared in the recent elections. There is always something festive in what Stephens Washington Bureau reporter Peter Urban calls a "biennial rite of passage": drawing lots for office space newly elected members of Congress will occupy during their terms.
Editorial: Cyberdating Abuse A Modern Expression Of Old Evil Nov 19 2014 - 4:35amComments As if parents didn't already have enough to worry them, a new study , published in the journal Pediatrics, suggests that 40 percent of teens surveyed said they had experienced cyberdating abuse in the context of a dating relationship in the previous three months.
Editorial: Girls Inc. Offers Girls Freedom To Excel Mar 30 2014 - 4:05amComments For 80 years, whether members called it the Fort Smith Girls Club or Girls Inc. of Fort Smith, the organization has helped Fort Smith girls become strong, smart and bold.
Editorial: Trail Of Tears Anniversary Celebrated Mar 26 2014 - 4:35amComments Although it might seem more the occasion for grief than celebration, we admire the take on the forced relocation of his ancestors that Cherokee Principal Chief Bill John Baker offered Monday.
Editorial: Don't Waive Districts' Responsibility To Teach Mar 24 2014 - 4:35amComments A teaching friend once noted that education appears to be the only American enterprise in which people want the least they can get for their dollar. It's a cynical and sweeping generalization, of course, but one with just enough accuracy to be painful.
Editorial: Execution System Still Broken Mar 23 2014 - 4:35amComments At some very near date, Arkansas and Oklahoma — and the country as a whole — will have to decide what they are going to do about the death penalty.
Editorial: Marshals Coins Moving Forward Mar 21 2014 - 4:35amComments It was exciting earlier this week to get a look at designs for the commemorative coins to honor the 225th anniversary of the founding of the U.S. Marshals Service.
Editorial: Absentee Ballot Confusion Grows Mar 17 2014 - 4:35amComments The problematic intersection between the state's new voter ID law and absentee ballots apparently has not been cleared since Attorney General Dustin McDaniel's Feb. 10 opinion on the subject.
Editorial: Democracy Messy, But Sunshine Laws Help Mar 16 2014 - 4:35amComments Moving resolutely toward spring, we note a benchmark: It is once again Sunshine Week .
Editorial: FEMA Offers Protection Before Catastrophe Mar 14 2014 - 4:35amComments We usually think of the Federal Emergency Management Agency after a disaster happens, but the agency has helped some rural firefighters before the catastrophe this time.
Editorial: New Building Projects Positive Signs For Region Mar 12 2014 - 4:35amComments A handful of interesting developments last week promise improved city and county services in the area in the near future.


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Is there a way to set the sort order in Sheet Set Manager for the Model Views tab? Seems like a few releases ago it was alphabetical - now its random and almost impossible to locate a specific drawing in a large project.
Tried changing MAXSORT and it did not have an effect.
Absolutely. I can't find anything! Surely there must be a setting or a fix? Or is nobody using SSM?
We just completed a 532 sheet project using SSM and had no troubles finding drawings in the sheet set..... that being said, you could always create subsets of one sort or another to help divide up your set and find things easier (we've done that from time to time and it helps somewhat).
I have the same issue with Model View, it is not maintaining the order of the folders in the directory structure which are alphabetized.
pkolarik wrote:
...you could always create subsets of one sort or another to help divide up your set and find things easier.
No, the OP is talking about the drawings listed on the Model Views tab, not the Sheet List tab.
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Document - Sudan: Six youth activists detained
UA: 37/12 Index: AFR 54/006/2012 Sudan Date: 06 February 2012 URGENT ACTION SIX YOUTH ACTIVISTS DETAINED Six members of the student-led movement Girifna were arrested on 25 January, after taking part in a public forum on human rights. They are at risk of torture and other ill- treatment. Amar Dirar, Nagi Musa, Gazi Eltayeb, Mohamed Mahjoub, Sharif Kamal and Omar Hamid took part in a forum organized by Girifna on 25 January in the city of Omdurman. The event was held to commemorate the 2005 Beja massacre at Port Sudan and to condemn the lack of justice for the victims. Immediately after the forum, Amar Dirar, Nagi Musa, Gazi Eltayeb, Mohamed Mahjoub and Sharif Kamal were arrested by National Intelligence and Security Service (NISS) officials and taken to an undisclosed location. Omar Hamid was arrested on his way home from the forum. On 29 January the six activists were reportedly transferred to Kober Prison in the capital, Khartoum. If they are being held solely for peaceful participation in the forum, Amnesty International would consider them prisoners of conscience. Nagi Musa and Amar Dirar had previously been arrested by the police on 29 November 2011. They had been taking part in a public forum with other Girifna members in Omdurman market and distributing pamphlets encouraging activism around the issue of deteriorating socio-economic conditions in Sudan. They were detained and reportedly interrogated and tortured by NISS agents before being released days later without charge. Girifna, or the "we're fed up" movement, was established in October 2009 in the lead up to Sudan's 2010 presidential and parliamentary elections, to campaign against President Omar al-Bashir and the ruling National Congress Party. Please write immediately in Arabic, English or your own language: Calling on the authorities to release Amar Dirar, Nagi Musa, Gazi Eltayeb, Mohamed Mahjoub, Sharif Kamal and Omar Hamid immediately and unconditionally, if they are being held solely for taking part in a public forum; Urging them to ensure that the six activists are not tortured or otherwise ill-treated, and are given immediate access to their families, lawyers and any medical treatment they may require; Urging them to immediately stop the harassment and intimidation of activists in Sudan and to respect their right to freedom of expression and peaceful assembly. PLEASE SEND APPEALS BEFORE 19 MARCH 2012 TO: Minister of Justice Mr Mohammed Bushara Dousa Ministry of Justice, PO Box 302 Al Nil Avenue Khartoum, Sudan Fax: +249 183 764 168 Salutation: Your Excellency Minister of Interior Mr Ibrahim Mohamed Hamed Ministry of Interior PO Box 873 Khartoum, Sudan Salutation: Your Excellency And copies to: President HE Omar Hassan Ahmad Al Bashir Office of the President People's Palace PO Box 281 Khartoum, Sudan Fax: +249 183 770 621 Email: firstname.lastname@example.com Also send copies to diplomatic representatives accredited to your country. Please insert local diplomatic addresses below: Name Address 1 Address 2 Address 3 Fax Fax number Email Email address Salutation Salutation Please check with your section office if sending appeals after the above date.
URGENT ACTION SIX YOUTH ACTIVISTS DETAINED ADDITIONAL INFORMATION Inspired by protests throughout the Middle East and North Africa that began in Tunisia at the beginning of January 2011, hundreds of demonstrators throughout Sudan took to the streets in 2011 calling for democracy and an improvement in socio- economic conditions. The police and the NISS in Sudan responded by frequently arresting and ill-treating peaceful demonstrators. Student movements and organizations are regularly targeted by the NISS. From mid-December 2011 into January 2012, students at Khartoum University peacefully demonstrated in solidarity with the Manaseer, an ethnic group that were forcibly displaced from their land due to the construction of the Merowe dam, in River Nile state. The demonstrations were violently dispersed on 22 December by police and security forces using batons and teargas. Large numbers of students were arrested during and after the demonstrations, and some were seriously injured by the security forces, who used excessive force. Student activist and Girifna member Taj Alsir Jaafar was among those arrested. He is believed to have been arrested and detained for participating in a sit-in at Khartoum university, in part to protest against police violence. He is being held incommunicado in an unknown location. The 2010 National Security Act provides the NISS powers to search and seize assets and to arrest and detain people for up to four-and-a-half months without judicial oversight. The act also grants NISS agents immunity from prosecution for any act committed in the course of their work. Names: Amar Dirar, Nagi Musa, Gazi Eltayeb, Mohamed Mahjoub, Sharif Kamal Gender m/f: Male UA: 37/12 Index: AFR 54/006/2012 Issue Date: 06 February 2012


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Israel and the Palestinian TerritoriesWith over 60 detailed maps, hundreds of recommendations on accommodations, and unvarnished coverage of the area's political history, this is essential reading for all travelers to Israel. The guide covers the important archaeological and biblical sites, provides a rundown on diving spots, trekking routes, and other outdoor activities, and offers a helpful guide to volunteer work throughout Israel. color. |
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Admission is free Akko Allenby St Arab beach Beersheba Beit Ben Yehuda St Ben-Gurion Ben-Gurion airport built buses cafes central bus station centre century Christian Church city's closed Saturday cost Crusader Damascus Gate David Dead Sea Dizengoff St Druze East Jerusalem Eilat entrance felafel Friday from 9 Galilee Gaza Strip Golan Haifa HaYarkon St Hebrew Holy Hospice Hotel Israel Israeli Jaffa Gate Jaffa Rd Jericho Jesus Jewish Jews Jordan Katzrin Kibbutz King Mamluk minutes Mitzpe Ramon monastery Monday mosque Museum Muslim Nablus Nahariya Negev NIS students noon Old City open daily open Sunday Palestine Palestinian park Places to Stay Quarter restaurant road Roman Shabbat sherut singles/doubles Square Steimatzky street Sunday to Thursday synagogue take bus there's Thursday from 9 Tiberias ticket tion Tomb tour tourist information office town visitors walk walls West Bank Yehuda St Zion


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LUXOR, Egypt (AP) King Tut's face was unveiled for the first time in public — more than 3,000 years after the youngest and most famous pharaoh to rule ancient Egypt was shrouded in linen and buried in his golden underground tomb.
Archeologists carefully lifted the fragile mummy out of a quartz sarcophagus decorated with stone-carved protective goddesses, momentarily pulling aside a beige covering to reveal a leathery black body. The linen was then replaced over Tut's narrow body so only his face and tiny feet were exposed, and the 19-year-old king, whose life and death has captivated people for nearly a century, was moved to a simple glass climate-controlled case to keep it from turning to dust. "I can say for the first time that the mummy is safe and the mummy is well preserved, and at the same time, all the tourists who will enter this tomb will be able to see the face of Tutankhamun for the first time," Egypt's antiquities chief Zahi Hawass said from inside the hot and sticky tomb. "The face of the golden boy is amazing. It has magic and it has mystery," he added. Hawass said scientists began restoring the badly damaged mummy more than two years ago. Much of the body is broken into 18 pieces — damage sustained when British archaeologist Howard Carter first discovered it 85 years ago, took it from its tomb and tried to pull off the famous golden mask, Hawass said. But experts fear a more recent phenomenon — mass tourism — is further deteriorating Tut's mummy. Thousands of tourists visit the underground chamber every month, and Hawass said within 50 years the mummy could dissolve into dust. "The humidity and heat caused by ... people entering the tomb and their breathing will change the mummy to a powder. The only good thing (left) in this mummy is the face. We need to preserve the face," said Hawass, who wore his signature Indiana Jones-style tan hat. The mystery surrounding King Tutankhamun — who ruled during the 18th dynasty and ascended to the throne at age 8 — and his glittering gold tomb has entranced ancient Egypt fans since Carter first discovered the hidden tomb, revealing a trove of fabulous gold and precious stone treasures and propelling the once-forgotten pharaoh into global stardom. He wasn't Egypt's most powerful or important king, but his staggering treasures, rumors of a mysterious curse that plagued Carter and his team — debunked by experts long ago — and several books and TV documentaries dedicated to Tut have added to his intrigue. Archeologists in recent years have tried to resolve lingering questions over how he died and his precise royal lineage. In 2005, scientists removed Tut's mummy from his tomb and placed it into a portable CT scanner for 15 minutes to obtain a three-dimensional image. The scans were the first done on an Egyptian mummy. The results ruled out that Tut was violently murdered — but stopped short of definitively concluding how he died around 1323 B.C. Experts, including Hawass, suggested that days before dying, Tut badly broke his left thigh, an apparent accident that may have resulted in a fatal infection. The CT scan also provided the most revealing insight yet into Tut's life. He was well-fed and healthy, but slight, standing 5 feet, 6 inches tall at the time of his death. The scan also showed he had the overbite characteristic of other kings from his family, large incisor teeth and his lower teeth were slightly misaligned. The unveiling of Tut's mummy comes amid a resurgence in the frenzy over the boy king. A highly publicized museum exhibit traveling the globe drew more than 4 million people during its initial four-city American-leg of the tour. The exhibit will open Nov. 15 in London and later will make a three-city encore tour in the U.S. beginning with the Dallas Museum of Art. The Egyptian tourism industry is hoping to capitalize on that interest and draw tourists to Luxor to see something they could not in traveling exhibit — the mummy itself. The number of tourists who visit Tut's tomb is expected to double to 700 a day now that the mummy will be on display indefinitely, said Mostafa Wazery, who heads the Valley of the Kings for Egypt's Supreme Council of Antiquities. Most of Egypt's other identified mummies are on display in museums in Luxor and Cairo. But not every tourist was eager to find out that Tut's mummy was being moved to a modern, see-through case. "I really think he should be left alone in quiet, in peace," said British tourist Bob Philpotts after viewing Tut's tomb before the mummy was moved on Sunday. "This is his resting place, and he should be left (there)." Hawass said experts will begin another project to determine the pharaoh's precise royal lineage. It is unclear if he is the son or a half brother of Akhenaten, the "heretic" pharaoh who introduced a revolutionary form of monotheism to ancient Egypt and was the son of Amenhotep III. Sunday's unveiling ensured the boy pharaoh would remain eternal, said Hawass. "I can assure you that putting this mummy in this case, this showcase, can make the golden boy live forever," he said. Copyright 2007 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More Recipe Collections
Crystal's Creations From Friends
A Collection of different recipes I have received over the years.
(72 Recipes) Created by CLASSYCRYS
Recipes in this Collection
Incredible! 5.0/5
(5 ratings)
Very filling and tastes great. I grill my own chicken tenderloins with a little Lime Pepper Seasoning. I love this. With the dressing it's a little high in cal. & fat, but I splurge and have a great salad as a meal, and just watch my snacking during the day. Submitted by WANT2BEFITBY40 Carbs: 30.9g | Fat: 23.3g | Fiber: 5.9g | Protein: 19.3g | Calories: 464.5
Tangy feta and crunchy veggies work beautifully with hearty grilled chicken in this Greek salad recipe. It's hearty enough for a full meal! Submitted by CREATIVELIZA Carbs: 10.5g | Fat: 13.3g | Fiber: 2.7g | Protein: 24.1g | Calories: 255.2
Very Good 4.6/5
(80 ratings)
My family loves fried chicken, so when I saw something similar done on Biggest Loser, I had to try it. It's a great alternative to "fried" chicken. Submitted by JENNMARIE0830 Carbs: 20.4g | Fat: 1.8g | Fiber: 0.3g | Protein: 32.5g | Calories: 235.5
Very Good 4.5/5
(6 ratings)
A super easy to prepare, yummy crock pot meal! Submitted by SWEETPEAJESS Carbs: 38.4g | Fat: 1.1g | Fiber: 8.3g | Protein: 13.8g | Calories: 211.3
(no ratings)
Submitted by MERCEDES3414 Carbs: 20.3g | Fat: 8.5g | Fiber: 2.3g | Protein: 19.5g | Calories: 240.5
(no ratings)
This is my favorite recipe for breakfast! I'm pleased to see the not-so-bad nutrirional value. Submitted by MEYERMOMMA Carbs: 16.6g | Fat: 13.8g | Fiber: 1.4g | Protein: 17.7g | Calories: 263.4
Submitted by SPICEAHOLIC Carbs: 12.2g | Fat: 7.6g | Fiber: 0g | Protein: 35.2g | Calories: 265.2
Very Good 4.3/5
(61 ratings)
Cilantro, green pepper, onion, and garlic give this bean dish a spicy kick. Carbs: 16.4g | Fat: 0.4g | Fiber: 4.9g | Protein: 5.2g | Calories: 79.4
Very Good 4.8/5
(4 ratings)
Submitted by RAGGEDY_ANN Carbs: 38.7g | Fat: 16.5g | Fiber: 4.5g | Protein: 21.1g | Calories: 388.5
Very Good 4.8/5
(8 ratings)
Submitted by BREEHARDY Carbs: 18.5g | Fat: 23.3g | Fiber: 1.6g | Protein: 29.1g | Calories: 372.8
Very Good 4.7/5
(3 ratings)
This is from Eating for Life Cookbook Submitted by CATHIES Carbs: 14.7g | Fat: 6g | Fiber: 0.6g | Protein: 26.4g | Calories: 225.8
Very Good 4.3/5
(24 ratings)
Spicy and creamy shrimp, pasta and vegetables. Submitted by MOXIE6 Carbs: 54.2g | Fat: 2.8g | Fiber: 7.6g | Protein: 28.4g | Calories: 335.8
Incredible! 5.0/5
(9 ratings)
THIS IS A LIGHT DELICIOUS SALAD Submitted by BIGGTRAY Carbs: 8g | Fat: 3.2g | Fiber: 1.4g | Protein: 9.7g | Calories: 97.6
If you like shrimp, you'll love this recipe! Submitted by SPARKLES_MCGHEE Carbs: 7.2g | Fat: 7.8g | Fiber: 1.4g | Protein: 34.8g | Calories: 241.6
I used goat milk products. Submitted by RYEAXL1 Carbs: 24.7g | Fat: 9.1g | Fiber: 1.5g | Protein: 10.4g | Calories: 232
Very Good 4.7/5
(6 ratings)
Delicious Tortilla Soup Submitted by MLUDKE22 Carbs: 39.1g | Fat: 28.6g | Fiber: 10.7g | Protein: 31.3g | Calories: 520.8
Very Good 4.6/5
(7 ratings)
Great Breakfast that's high in protein and low in carbs. Submitted by CARRIEBEAR2 Carbs: 3.3g | Fat: 10.2g | Fiber: 0g | Protein: 24.7g | Calories: 217.3
This lighter version of an old classic is made with lower-calorie baking mix and ground turkey instead of beef. Submitted by TXCYNDI Carbs: 10.7g | Fat: 4.5g | Fiber: 0.3g | Protein: 21.2g | Calories: 166.5
Very Good 4.6/5
(19 ratings)
Meatballs in a pineapple sweet and sour sauce. Best served over rice. Submitted by DOITNOWM Carbs: 28.6g | Fat: 16.9g | Fiber: 0.9g | Protein: 15.5g | Calories: 330.8
Very Good 4.7/5
(3 ratings)
Submitted by WLFPACK1 Carbs: 22.7g | Fat: 50.9g | Fiber: 0.4g | Protein: 42g | Calories: 725.2


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text: EURAP An International Antiepileptic Drugs and Pregnancy Registry Interim Report May 2008 Central Study Coordinator Dr Dina Battino Fondazione I.R.C.C.S. Istituto Neurologico "Carlo Besta" Via Celoria 11 20 133 Milano, Italy Tel: + 39 (0)2 23 94 2230 Fax: + 39 (0)2 700 42 91 60 E-mail: firstname.lastname@example.com Chairman Central Project Commission Dr Torbjörn Tomson Department of Neurology Karolinska University Hospital S-171 76 Stockholm Sweden Tel: + 46 (0)8 51773705 Fax: + 46 (0)8 51773757 E-mail: email@example.com 1 BACKGROUND All old-generation antiepileptic drugs (AEDs) are considered to be teratogenic and AEDs are among the most common causes of adverse effects to the foetus. The risks associated with the treatment of epilepsy during pregnancy is therefore of major concern to all women of childbearing potential with epilepsy. The information on the comparative teratogenicity of these AEDs in humans is, however, conflicting, mainly due to inadequate sample size and methodological differences between previous studies. The teratogenic potential of newer AEDs is even less known, a situation that prevents a rational approach to AED treatment in women of childbearing potential. To address this problem, it is necessary to compile more information on outcome of pregnancies following maternal exposure to AEDs. Such information is needed to provide pre-pregnancy counselling concerning teratogenic risks, and possibilities for specific prenatal monitoring, including prenatal diagnosis of foetal disorders associated with specific medications. Given the current number of available AEDs and combinations, very large numbers of pregnancies have to be evaluated in order to establish the safety of each regimen. Large denominators are also needed because of the qualitative diversity of the main endpoint of outcome, major congenital malformations. A number of independent groups with experience and interest in maternal and foetal well-being in association with maternal AED use have agreed on a prospective international multi-centre study of pregnancies with AEDs. Data from all participating groups are shared in a Central Registry of Antiepileptic Drugs and Pregnancy (EURAP). EURAP was established in the first centres in some European countries and has since then gradually expanded to include more centres and countries now involving also Asia, Oceania and Latin America. OBJECTIVE OF EURAP The primary objective of EURAP is to evaluate and determine the comparative risk of major foetal malformations following intake of AEDs (old and new) and their combinations during pregnancy. METHODS EURAP is a prospective and retrospective observational study. Women taking AEDs at the time of conception, irrespective of the indication, may be included. To avoid selection bias, only pregnancies recorded before foetal outcome is known and within week 16 of gestation are included in the prospective risk assessment. Cases ascertained later in pregnancy are recorded as retrospective cases, as they may provide signals, but are not included in the comparative risk evaluation. Information on patient's demographics, type of epilepsy, seizure frequency, family history of malformations, drug therapy and of other potential risk factors is obtained, and follow-up data are collected once at each trimester, at birth and at one year after delivery. Networks of reporting physicians have been established in countries taking part in the collaboration. During the course of the pregnancy, and the follow-up time after delivery, the participating physician enters data into five Subforms (Subforms A-E) for each patient. Subform A is completed on enrolment of the patient, Subform B after the first trimester, Subform C after the second trimester, Subform D within three months after delivery, and Subform E within 14 months after birth. Immediately after completion, each Subform is submitted to the national coordinator for review. The 2 national coordinator transfers the reviewed and accepted Subform to the Central EURAP Registry in Milan, Italy. EVALUATION OF OUTCOME The physician records descriptively abnormalities observed in the offspring. The final assessment and classification of the type of malformation is the responsibility of the Central Project Commission (CPC). In order to facilitate a uniform and objective assessment, reports of malformations are assessed regularly by an outcome assessment committee, which is kept blinded with respect to the type of exposure. Outcome in relation to exposure to individual drugs or drug combinations will be assessed only after sufficient data is available for a meaningful statistical analysis. Determination of the sample size needed is complicated by lack of reliable information about the distribution of individual drugs and their combinations and about the prevalence of the teratogenic event. Applying the general empirical rule that the ratio between the overall number of events (teratogenic events) and the number of explanatory variables (predictors) should be at least equal to 10, a total sample size of at least 5,000 prospectively ascertained pregnancies would be needed to allow analysis of 25 predictors (different AEDs and other relevant risk factors) assuming a prevalence of malformations in the order of 5%. INTERIM REPORT EURAP was implemented in the first two countries in Europe in 1999 and has since then grown rapidly with increasing numbers of participating countries from Europe, Australia, Asia and South America. This development is also reflected by increasing numbers of enrolled pregnancies. The development since 1999 is illustrated in Fig. 1. 3 Fig 1 Number of participating countries and pregnancies reported to the Central Registry by May 2008. 40 Number of countries Registered pregnancies 12000 11463 35 10726 9832 30 8785 8090 8000 25 7236 6417 20 5558 15 4667 3962 4000 10 3219 2406 5 1738 661 1004 0 25 78 321 0 Se Se 00 Se 01 Se 02 Se 03 Se 04 Se 05 Se 06 Se 07 M M 0 M 1 M 2 M 3 M 4 M 5 M 6 M 7 ar ar ar ar ar ar ar ar ar pt pt pt pt pt pt pt pt pt ch ch ch ch ch ch ch ch ch 99 0 0 0 0 0 0 0 0 08 The present report is based on data available in the Central Registry by May 6, 2008. At that time more than 750 reporting physicians from 42 countries had contributed cases to the Central Registry. Countries that had been active are listed in Table 1. Table 1 Countries that have contributed with pregnancies reported to the Central Registry of EURAP Albania Argentina Australia Austria Belgium Belarus Chile China Croatia Czech Republic Denmark Emirates Finland France Georgia Germany Guatemala Hong Kong Hungary India Israel Italy Japan Lithuania Macedonia The Netherlands Norway 4 Philippines Poland Portugal Russia Scotland Serbia and Montenegro Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey Ukraine United Kingdom By the cut-off date for this report (6 May 2008), 11,628 pregnancies had been entered into the central database. Of these, 2,502 were retrospective, a further 1,308 are excluded for reasons specified below (point 1 and 2), 988 are pending (awaiting updates or corrections of different sub-forms), 1,208 are ongoing pregnancies and 5,292 are prospective which have completed the study including the one-year follow-up after birth. Reasons for not including pregnancies in the present interim report were: 1. Pregnancies that failed to meet inclusion criteria (n=47). 2. Lost to follow-up, including those failing to submit sub-forms within preset deadlines (n=1,261). 3. Pending pregnancies, awaiting updates or corrections of different sub-forms (n=988). 4. Ongoing pregnancies, updated and corrected (n=1,208). 5. Retrospective, but completed and corrected (n=2,014). 6. Retrospective, i.e. initially classified as prospective pregnancies but finally accepted as retrospective cases because one or more CRF subforms were submitted after the set deadlines (n=150). 7. Unclassifiable i.e. cases for which it was impossible to determine if there was a malformation or not (n=14). This includes fetal loss with unknown fetal status (n=3), induced abortion with insufficient information on fetus (n=2), and anomalies in livebirths where the information was insufficient to determine if qualifying for malformation diagnosis (in most cases abdominal hernias. 8. Pregnancies completed by the cut-off date, but too recent (after April 9, 2008) for having their classification of outcome completed in time for this report (n=235). 9. Treatment changes between different AEDs or mono- to polytherapy or vice versa during the first trimester (n=419). Thus in total 5,292 prospective pregnancies (enrolled at the latest during the 16 th gestational week) are included in this report. Seventy-six of these pregnancies (1.4%), that otherwise met our criteria for prospective pregnancies, had an ultrasound examination performed before enrolment. The classification of the epilepsy among the prospective pregnancies is given in table 2. Epilepsy was the indication for treatment in all but 50 (1%) of the pregnant women. 5 Table 2 Classification of the epilepsy in 5,292 prospective pregnancies. Epilepsy N % Generalized 2,212 41.8 Localisation-related 2,754 52.0 Undetermined 184 3.5 Missing information 92 1.7 No epilepsy 50 1.0 Total 5,292 100.0 The maternal age among prospective cases was 29.6±5.1 years (mean±SD), ranging from 14 to 45 years. The women were of Caucasian ethnicity in 89.6% and of Asian in 6.6%. The number of the current pregnancy in individual women is presented in Table 3. Table 3 Number of the pregnancy in prospective cases Gravida N % 1st pregnancy 2,432 45.9 2nd pregnancy 1,606 30.4 3rd pregnancy 725 13.7 4th pregnancy 311 5.9 5th pregnancy 132 2.5 > 5th pregnancy 86 1.6 Total 5,292 100.0 The outcome of the prospective completed pregnancies is presented in Figure 2. Out of the 152 induced abortions, 33 were for fetal indication (major malformation or other abnormalities detected by prenatal screening). 6 Figure 2 Outcome of prospective pregnancies. 5000 4666 4500 4000 Number of pregnancies 3500 3000 2500 2000 1500 1000 500 359 152 78 37 0 Livebirths Spontaneous Induced Stillbirths Perinatal deaths abortions abortions Of the pregnancies, 4214 (80.5%) involved women on a single AED, 872 (16.6%) were on two AEDs whereas 151 (2.9%) took three AEDs or more. Fifty-five women (1.0%) were not on AED treatment during the 1st trimester. The exposure to the different AEDs in monotherapy among the prospective pregnancies is presented in Figure 3. Figure 3 Number of prospective pregnancies with exposure to different AEDs in monotherapy 7 There were 179 different AED combinations. The most frequently used combinations were lamotrigine and valproic acid (n=135), carbamazepine and lamotrigine (n=75), carbamazepine and phenobarbital (n=52) and carbamazepine and valproic acid (n=51) (Table 4). Table 4. The most common AED combinations lamotrigine + valproic acid 135 carbamazepine + lamotrigine 75 carbamazepine + phenobarbital 52 carbamazepine + valproic acid 51 lamotrigine + levetiracetam 39 carbamazepine + levetiracetam 32 carbamazepine + topiramate 28 phenobarbital + valproic acid 26 lamotrigine + topiramate 26 carbamazepine + clobazam 24 clonazepam + valproic acid 23 carbamazepine + clonazepam 20 lamotrigine + phenobarbital 17 lamotrigine + clonazepam 17 phenobarbital + phenytoin 17 The number of pregnancies with exposure to different new generation AEDs taken in combination with other AEDs are listed in Table 5. Table 5 Number of pregnancies with different new generation AEDs in combination therapy AED N Lamotrigine 449 Topiramate 137 Levetiracetam 128 Oxcarbazepine 73 Gabapentin 39 Vigabatrin 32 Tiagabine 7 Zonisamide 5 Pregabaline 2 8 TERATOGENIC OUTCOME There were 280 major congenital malformations (MCM) and 47 chromosomal (CHR)/monogenic abnormalities in the prospective cohort of 4,933 pregnancies (spontaneous abortions excluded) as shown in Table 6. Table 6 Outcome Outcome classification N MCM Multiple major 24 Isolated major 254 Association* 1 Sequence‡ 1 280 CHR or monogenic CHR 36 Monogenic 11 47 Total 327 *idiopathic pattern of multiple anomalies arising during blastogenesis. ‡pattern of multiple anomalies derived from a single known or presumed prior anomaly or mechanical factor In this report we will confine our analysis to the 280 MCM including 28 induced abortions, five stillbirths and eight neonatal deaths. Of the 239 live births, 22 cases of malformations were ascertained prenatally, 130 were first reported at birth and 87 within one year after birth. Among the 280 cases with MCM, 53 were detected by ultrasound examination. Out of these 53, there were 27 induced abortions, 4 stillbirths and 22 live births. The 280 cases represent a malformation rate of 5.7% of all prospective pregnancies for which follow-up has been completed (280/4,933), and the same rate of 5.7% is obtained if the 68 cases with ultrasound before enrolment are excluded (276/4,865). The type of malformations is described in Table 7. 9 Table 7 CHR or APPARATUS / ICD-9-CM coding MCM monogenic MCM Nervous system 740 Anencephalus and similar anomalies 3 0 741 Spina bifida 24 0 742 Other congenital anomalies of nervous system 6 2 Eye 743 Congenital anomalies of eye 4 1 Congenital heart disease 745 Bulbus cordis anomalies and anomalies of cardiac septal closure 47 4 746 Other congenital anomalies of heart 6 0 747 Other congenital anomalies of circulatory system 8 2 748 Congenital anomalies of respiratory system 1 0 Oro facial clefts 749 Cleft palate and cleft lip 16 0 Digestive system 751 Other congenital anomalies of digestive system 5 0 Genital 752 Congenital anomalies of genital organs 38 1 Urinary 753 Congenital anomalies of urinary system 19 0 Limbs 755 Other congenital anomalies of limbs 2 0 755.0 Polydactyly 1 0 Musculo-skeletal deformities 754 Certain congenital musculoskeletal deformities 23 1 Other musculo-skeletal anomalies 756 Other congenital musculoskeletal anomalies 4 2 756.0 Anomalies of skull and face bones 5 0 756.6 Anomalies of diaphragm 4 0 Skin 757 Congenital anomalies of the integument 0 1 Other and unspecified congenital anomalies 759 Other and unspecified congenital anomalies 0 4 Association 1 0 Multiple Major 24 Sequence 1 Chromosomal anomalies 758 Chromosomal anomalies 0 26 Outside malformation chapter codes 210-229 Benign neoplasm* 3 1 550-553 Hernia of abdominal cavity 35 0 270 Disorders of amino-acid transport and metabolism** 0 1 320-389 Diseases of the nervous system and sense organs 0 1 Total 280 47 10 *Haemangiomas **Albinism In 238 out of 3,949 pregnancies with AED monotherapy one or more birth defects were observed (6.0%), as opposed to 87 out of 932 pregnancies with AED polytherapy (9.3%) as shown in Table 8. Table 8 Monotherapy Polytherapy N % N % MCM 198 5.0 80 8.6 CHR or monogenic 40 1.0 7 0.7 No malformation 3,711 94.0 845 90.7 Total 3,949 100 932 100 Outcome in relation to exposure to individual drugs or specific drug combinations will not be assessed or reported until more pregnancies have been completed (c.f. Evaluation of outcome section above). 11 ORGANISATION, FUNDING AND SUPPORT EURAP is a consortium of independent research groups working on a non-profit basis. The project is administratively organised by the Central Project Commission (CPC) with members representing different geographical areas and disciplines. The project has been supported by educational grants to the CPC from Eisai Pharmaceuticals, GlaxoSmithKline, Janssen-Cilag, Johnson & Johnson, Pfizer, Sanofi-Synthelabo, UCB Pharma and. In addition, national and regional networks may receive support from the same or other pharmaceutical companies. 12 APPENDIX Central Project Commission Dina Battino, Milano Erminio Bonizzoni, Pavia John Craig, Belfast Dick Lindhout, Utrecht Emilio Perucca, Pavia Anne Sabers, Copenhagen Torbjörn Tomson, Stockholm, (chair) Frank Vajda, Melbourne Central Study Coordinator Dina Battino, Milan Scientific Advisory Board Bernd Schmidt, Freiburg Martin J Brodie, Glasgow Outcome Assessment Committee Richard Finnell, Houston, Texas Francesca Faravelli, Genoa, Italy Elisabeth Robert-Gnansia, Lyon, France 13 National/Regional Coordinators Silvia Kochen, Argentina Frank Vajda, Australia Gerhard Luef, Austria Dick Lindhout and Klara Flipsen-ten Berg, Benelux Alejandro de Marinis, Chile Dinko Vitezic, Croatia Jana Zarubova and Robert Kuba, Czech Republic Anne Sabers, Denmark Reetta Kälviäinen, Finland Otar Toidze and Sofia Kasradze, Georgia Bettina Schmitz, Germany Patrick Kwan, Hong Kong Gábor Barcs, Hungary Sanjeev V Thomas, India Miri Neufeld, Israel Daniela Mamoli and Aldo Paggi, Italy bibiana! 28-7-08 10:15 Formattato: Non Evidenziato Hideyuki Ohtani, Japan Ruta Mameniskiene, Lithuania Gordana Kiteva-Trencevska, Macedonia Karl-Otto Nakken, Norway Weiping Liao, People's Republic of China Leonor Cabral-Lim, Philippines Joanna Jedrzejczak, Poland Alla Guekht and Oksana Lokshina, Russia 14 Aline Russell, Scotland Dragoslav Sokic, Serbia and Montenegro Vladimir Safcak, Slovakia Bostjan Cebular, Slovenia Meritxell Martinez Ferri, Spain Torbjörn Tomson, Sweden Barbara Tettenborn and Heike Juch, Switzerland Chi-Wan Lai, Taiwan Çigdem Özkara, Turkey John Craig, UK and Ireland 15


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I am a student of IIT,kharagpur and working on making compilers (like GCC) to be adaptable to multi-core architecture but I have am facing a problem that is I don't ...
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- 03-28-2013 #1
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which version of GCC is adapted to multi-core architecture
- 03-29-2013 #2
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As far as I know, all GCC versions since 4.x have multi-core optimizations available (RTFM); however, you need to use posix threads to maximize your utilization of the available cores. Reading papers is not a substitute for experimentation and experience...
Sometimes, real fast is almost as good as real time.
Just remember, Semper Gumbi - always be flexible!


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Today, Street View also covers over 50 landmarks and World Heritage sites, including iconic places in Malaysia such as Batu Caves, Taman Negara, Langkawi, Penang Hill, Malacca City and Presint 1, Putrajaya.
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While it's likely that there are no Texas drug rehab programs that provide specific treatment for people who can't keep their hands off their beeping cell phones, this study did have some findings that might be interesting for you, as you think about your addiction.
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