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Senior Member
EDIT: Whoops! Turns out that Ionic is about 1.1k less gold efficient than Wit's and Madred's! That's a lot more gimpy than I thought it was. This thing needs buffed hardcore. Allow me to suggest a bit of a rework... Chainmail (700) Dagger (420) Ruby Crystal (475) Combine cost (705) Total: 2300 Grants 45 armor (765) 50 IAS (1400) 300 HP (780) 100 damage chain-lightning (1050) Total: 3995 There! Now it's well in line in terms of cost-effectiveness with Wit's and Madred's.
I dont mind that it sucks or else. Whats the role of this item, What is Riot trying to achieve? Maybe trying to allow Ranged AD to deal with hard pushers? A proper solution would be to REMOVE PROMOTE. But really what is riot trying to achieve with this item?
Señor Pancho
Tale Feather
They wanted an option for certain melee carries without heavy AoE utilties to be able to clear minion waves faster and have better DPS in skirmishes and teamfights, that's what. Ionic Spark has its place on certain champions. Especially pusher ranged carries, or pretty much anyone who benefits from attack speed. It matches or betters Wit's End in situations which you are not fighting an AP heavy team as HP gives you a bit more longevity to begin with. It shares the 3rd item slot for me on me for a AS Kayle build, along with Wit's End and some specific champion-counter items.
Hugs From Momma
It's not very good for the price. Brackhar said he'd review it: http://na.leagueoflegends.com/board/showthread.php?t=1403893&page=2
The price could use adjustment, that's for sure. But it's use shouldn't be questioned. It's survivability + attack Speed + AoE magic damage all rolled into one, and it's very helpful in clearing creeps on a AS carry. Granted, all in small amounts, hence the price needs a slight adjustment. But it's not a terrible item in the least.
I used it on kog once, it had its uses but i was not impressed with it.
If you compare the cost effectiveness of Spark to Kit's Bloodrazor and Wit's it becomes very clear that this item is underpowered when contrasted with other IAS/OnHit items. If you count the magic damage as the same value as physical damage (silly I know, but it works out fine for this contrast) Bloodrazor and Wit's are both about 1.7k over-budget given the stats they provide. Ionic is about 600 gold over. Bloodrazor and Wit's both have 1.1k greater gold efficiency. Strike my first comment that this thing needs a minor buff. It needs to be buffed hardcore.
I've been getting it on Jarvan lately as an early item. I normally go bot, and the AoE damage is nice in push games. It's also nice, in that it in teamfights, it's an assist generator. I agree that when compared against similiar items, it is a bit underwhelming. However, damage on hit items are already fairly strong, and I would be wary of making too many that are too good were I in the designers shoes.
The AoE damage is actually pretty nice helping things without AoE keep bottom pushed, having said that the onhit damage feels a little low (75 to the dom minions, bleh), and as far as 'random things that give attackspeed' go it's got less attackspeed than say, malady, wit's end, nashor's, etc. making it a pretty hard sell imo.


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Kiko Jones
I think I read somewhere Walla saying that having that much of a hand in the production AND being a member of the band was taking a bit of a toll on him.
"Thom Yorke (who has already spoken out against Spotify) is constantly experimenting with new ways to release music in a way that is fair and beneficial to both musicians and consumers."
He's counting on the über fans who will pay upwards of $50 for the deluxe versions of his band's albums, since he knows the casual listener will download the album for free.
"People still attend concerts."
Concertgoers are paying for the misdeeds of freeloaders with exorbitant ticket prices, and that's not taking into account the artists who scalp their own tickets. I also don't understand how one can refuse to pay $10 for a record you love and can keep forever but pay $250 to see that artist play from crappy seats once.
"People still support the artists they love precisely because they have a deep respect for their craft. People freely share other artist's music precisely because they value it highly. People purchase vinyl even though they could (with less effort) freely load up a 150 GB iPod with entire catalogs of music."
The percentage of music lovers who support artists is minute in regards to the total amount of music consumers. If not, we wouldn't be having this discussion. I know folks who stopped purchasing music more than a decade ago, but they still find a way to get a ton of music. How dow they do it? Hmm…
Vinyl sales are largely fetish/cool factor driven: that's why people pay $25+ for wax but refuse to pay significantly less for CDs or high quality mp3s/FLAC, etc.
"Indie bands that have existed for barely over a year are playing in front of huge festival crowds. Old indie bands that could've easily faded into obscurity are experiencing a renaissance and re-forming to release new music (do you really think someone like Michael Gira would experience the most success he's ever had with Swans if it weren't for the internet?)."
Absolutely. But let's not confuse access and dissemination of info about an artist with illegal downloads. In other words, can we not conflate the internet as a vital tool with the specificity of "file sharing"?
"And the only people complaining about a decline in the quality of music correlating with the decline of the music industry are those who are unwilling to put in an effort to research new music. And even then, modern day music journalism (i.e. Pitchfork and the like) thrives because people need their music curated. If anything, the music world is being over-saturated with new artists. So instead of letting the Billboard charts decide what you pay attention to, you allow Pitchfork to shape your tastes."
There IS a significant dip in the quality of music within the mainstream: now that major labels have seen their revenues decrease dramatically, they are investing more than ever before in cookie cutter, sure thing music. And you know who doesn't "put in an effort to research new music"? The casual music fan, ie the vast majority of the music consuming public. The majority of which will never spend a penny on music ever again.
As for music journalism, don't get me started…I've come across too many reviews in the last decade in which the writer is too ignorant to know that the band whose fresh, innovative, visionary sound he/she is hyping is actually a bad Wire ripoff.
Aloe Blacc, who co-wrote Avicii's "Wake Me Up" says he saw $4,000 from 168 MILLION streams of that song. If that statement is true, ballgame over.
I don't need a dude who's financially set for life telling me to give away my shit and further rubbing it in by saying he doesn't care since he's playing Wembley soon. That's some clueless, self-centered, tone deaf bullshit right there.
Oh, and btw, in a standard recording contract from back in the day the artist (bandmembers) didn't get paid until the record recouped, but songwriters got paid from copy 1 that sold, regardless of recouping. So, let's say your major label album flopped to the tune of 75,000 copies, but you as an individual wrote all 10 songs, that's close to $70K songwriting revenue. Split with publishing and management, but still…
You make a good point re: artists. But we need to differentiate "artists" from "songwriters".
Let's use a fictional band as an example. The Earnest Ones are a three piece and Michael their singer/guitarist writes all the songs. Back in the day they were signed to a major label and although a tad popular, they sold a decent amount of records–say, 80,000 copies each album–but not enough to break even and for the label to pay the band. So, The Earnest Ones never made any money from those albums. But Michael did. As a songwriter, by law, he's supposed to get paid a royalty on every single album sold, starting from copy sold no.1. Doesn't matter if these albums recoup or not. So if The Earnest Ones had 3 albums with 10 songs each, all written by Michael–and if my math is correct–as a songwriter he got paid 90¢ per album (9¢ per song, split with his publisher), which is more than $70K per album. His bandmates, meanwhile, made zilch b/c they didn't have songwriting revenue and the artist revenue went to recouping the money spent on recording, promotion, videos, etc. which was charged to The Earnest Ones. Michael, made no money as the "artist" (ie a member of The Earnest Ones) but he got paid as the "songwriter".
"[D]udes like Daniel Johnston were recording albums for Atlantic Records" b/c the majors were out of the loop as to what the youth was consuming–for the first time since the second half of the '60s–and were flush with enough cash to experiment. We have the exact opposite situation now: they know what sells and are reluctant to spend even a dime on anything that doesn't smell like a sure thing.
Aloe Blacc says he made $4000 from "Wake Me Up", a song which he co-wrote for Avicii and streamed 168 million times. So, based on that math, it would take billions of streams to make $6m.
So, this tune is a hit?
- The six albums from the reunited "classic" lineup should be at the bottom of the pile.
- 'Do the Collapse' gets an unnecessary bad rap.
- Any album with such all-around consistency and no Tobin Sprout songs (yay!) like 'Mag Earwhig', deserves a much higher spot.
My 2¢.
Fwiw, here in NYC I frequently come across children of Gen-Xers in their early 20s who love classic rock AND the whole Seattle/alternative/"grunge" of the early '90s. (It's a question of authenticity for them: they feel the rock music of the 21st century is, for the most part, contrived and plastic; too tightly tethered to vague notions of hipness.)
I'm a Gen-Xer myself and 'Superunknown' is not the only record from that era which I still enjoy, but it's the only one I play regularly, as if it had been released in the last 5 years.
Ryan Leas can't put his finger on why the album feels massive to him. Perhaps it's due the fact that when you listen closely to this 70-minute, tour de force you can sense that the band knew it was onto something; that their songwriting had turned a corner and the need to make a lasting musical statement was in the air. In other words, it seems like the band approached this record as much more than their latest batch of songs. Hands down THE hard rock record of the '90s.
Yeah, that phone call was the way to go…IF she'd seen the video before it leaked. What was the point of Badu calling Coyne after the video was out there for all to see? I'm on Team People Need to Stop Jumping to Conclusions Before They Figure Things Out.

subset: commoncrawl


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APWith less than 30 days to go until the deadline to reach a deal on the fiscal cliff, conservative House Republicans are taking their cues from Grover Norquist, the anti-tax crusader behind the GOP's "no new taxes pledge."
Over the past two years, Norquist has become a household name, gaining notoriety for his role in shaping the Republican anti-tax dogma that rejects any additional revenues for the federal government. But there is more to Norquist than his tax pledge. The 56-year-old activist has a surprisingly backstory that makes him one of the most fascinating — and enigmatic — characters in Washington.
He's actually funny!
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CSA: Freedom Valley Farm
Operates: May-October
(1 review)
Contact Information
Jim Baughman
(317) 508-3845
Check out our Micro-greens option for the CSA. 2 oz. per week, for an additional $86.00 for the 24-week season!
CSA Details
Season: May through October
Type: single farm
Since: 2010
Full Share: $595 for the 24-week season. Partial season shares available, with a 12-week minimum.
1/2 Share: $355 for a half share for the 24-week season. Partial season half shares available with a 12-week minimum.
Work Req? No
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Bloomington Community Farmers Market
Members pick up their shares at the Bloomington Community Farmers Market,
401 N. Morton St
Bloomington, IN 47404
Bloomington Tuesday Market
May 6, 2014 through October 2014, Tuesdays, 4pm to 7pm. The Tuesday Market is next to Bloomingfoods Near Eastside store in Bloominton
316 West 6th Street
Bloomington, IN 47404


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Publications (38)257.52 Total impact
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ABSTRACT: Although the role of transforming growth factor-β (TGF-β) signaling in the development and progression of cancer is now beginning to be understood, the importance of signaling by bone morphogenetic protein (BMP) ligands is just becoming clear, and much less is known about the mechanisms by which BMP signaling may mediate carcinogenesis. We have shown that the Smad proteins which mediate signals from the BMP cell surface receptors can interact with histone methyltransferases of the Suv39h family, and that this interaction can contribute to transcriptional repression mediated by BMP signaling. This provides the first evidence that BMP signaling can modulate chromatin structure through methylation, and may provide a mechanism for maintenance of suppression originally initiated by Smad signals. Aberrant regulation of this phenomenon is likely to be important both during tumorigenesis and subsequent malignant progression. Key WordsHistone methyltransferase-Smad-BMP-cell surface receptors-Suv39h family-chromatin12/2007: pages 383-393; - [Show abstract] [Hide abstract]
ABSTRACT: The transforming growth factor-beta (TGF-beta) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-beta receptor III is the most common TGF-beta pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.Journal of Molecular Endocrinology 12/2007; 39(5):329-32. · 3.62 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Transforming growth factor (TGF)-beta1 activity has been shown to increase vascular endothelial barrier permeability, which is believed to precede several pathologic conditions, including pulmonary edema and vessel inflammation. In endothelial monolayers, TGF-beta1 increases permeability, and a number of studies have demonstrated the alteration of cell-cell contacts by TGF-beta1. We hypothesized that focal adhesion complexes also likely contribute to alterations in endothelial permeability. We examined early signal transduction events associated with rapid changes in monolayer permeability and the focal adhesion complex of bovine pulmonary artery endothelial cells. Western blotting revealed rapid tyrosine phosphorylation of focal adhesion kinase (FAK) and Src kinase in response to TGF-beta1; inhibition of both of these kinases using pp2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), ameliorates TGF-beta1-induced monolayer permeability. Activation of FAK/Src requires activation of the epidermal growth factor receptor downstream of the TGF-beta receptors, and is blocked by the epidermal growth factor receptor inhibitor AG1478. Immunohistochemistry showed that actin and the focal adhesion proteins paxillin, vinculin, and hydrogen peroxide-inducible clone-5 (Hic-5) are rearranged in response to TGF-beta1; these proteins are released from focal adhesion complexes. Rearrangement of paxillin and vinculin by TGF-beta1 is not blocked by the FAK/Src inhibitor, pp2, or by SB431542 inhibition of the TGF-beta type I receptor, anaplastic lymphoma kinase 5; however, pp1 (4-Amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), which inhibits both type I and type II TGF-beta receptors, does block paxillin and vinculin rearrangement. Hic-5 protein rearrangement requires FAK/Src activity. Together, these results suggest that TGF-beta1-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src-dependent and -independent pathways.American Journal of Respiratory Cell and Molecular Biology 11/2007; 37(4):485-93. · 4.11 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and transformation. We demonstrate that SNIP1 functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc both by stabilizing it against proteosomal degradation and by bridging the c-Myc/p300 complex. These effects of SNIP1 on c-Myc likely contribute to synergistic effects of SNIP1, c-Myc, and H-Ras in inducing formation of foci in an in vitro transformation assay and also in supporting anchorage-independent growth. The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis.Molecular Cell 01/2007; 24(5):771-83. · 14.46 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Transforming growth factor-beta (TGF-beta) is the prototypical member of a family of growth factors that play important roles in normal development and human diseases. We identified the gene for fibroblast growth factor-binding protein 1 (FGF-BP1) as being significantly repressed following TGF-beta treatment. FGF-BP1 is an extracellular matrix bound protein that enhances fibroblast growth factor (FGF) signaling. We demonstrate here that TGF-beta signaling significantly represses FGF-BP1 expression in mesenchymal and neural crest cells undergoing in vitro smooth muscle differentiation. Analysis of the downstream signaling pathways shows that Smad2/3 are crucial for efficient FGF-BP1 repression by TGF-beta. Furthermore, we identified a novel element in the region from -785 to -782 bp of the FGF-BP1 promoter, which represents a known binding site for Hypermethylation in Cancer-1 (Hic-1), necessary for repression of FGF-BP1 by TGF-beta. These data define the molecular mechanism of transcriptional repression of an important target of TGF-beta signaling during angiogenesis.Biochemical and Biophysical Research Communications 07/2006; 345(2):595-601. · 2.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We recently reported that transforming growth factor (TGF)-beta induced the neural crest stem cell line Monc-1 to differentiate into a spindle-like contractile smooth muscle cell (SMC) phenotype and that Smad signaling played an important role in this phenomenon. In addition to Smad signaling, other pathways such as mitogen-activated protein kinase (MAPK), phosphoinositol-3 kinase, and RhoA have also been shown to mediate TGF-beta actions. The objectives of this study were to examine whether these signaling pathways contribute to TGF-beta-induced SMC development and to test whether Smad signaling cross-talks with other pathway(s) during SMC differentiation induced by TGF-beta. We demonstrate here that RhoA signaling is critical to TGF-beta-induced SMC differentiation. RhoA kinase (ROCK) inhibitor Y27632 significantly blocks the expression of multiple SMC markers such as smooth muscle alpha-actin, SM22alpha, and calponin in TGF-beta-treated Monc-1 cells. In addition, Y27632 reversed the cell morphology and abolished the contractility of TGF-beta-treated cells. RhoA signaling was activated as early as 5 min following TGF-beta addition. Dominant negative RhoA blocked nuclear translocation of Smad2 and Smad3 because of the inhibition of phosphorylation of both Smads and inhibited Smad-dependent SBE promoter activity, whereas constitutively active RhoA significantly enhanced SBE promoter activity. Consistent with these results, C3 exotoxin, an inhibitor of RhoA activation, significantly attenuated SBE promoter activity and inhibited Smad nuclear translocation. Taken together, these data point to a new role for RhoA as a modulator of Smad activation while regulating TGF-beta-induced SMC differentiation.Journal of Biological Chemistry 02/2006; 281(3):1765-70. · 4.60 Impact Factor -
Article: Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.
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ABSTRACT: Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) superfamily ligands to regulate the expression of target genes. In order to identify novel partners of Smad proteins in transcriptional regulation, we performed a two-hybrid screen using Smad5, a protein that is activated predominantly by bone morphogenetic protein (BMP) signaling. We identified an interaction between Smad5 and suppressor of variegation 3-9 homolog 2 (Suv39h2), a chromatin modifier enzyme. Suv39h proteins are histone methyltransferases that methylate histone H3 on lysine 9, resulting in transcriptional repression or silencing of target genes. Biochemical studies in mammalian cells demonstrated that Smad5 binds to both known mammalian isoforms of Suv39h proteins, and that Smad proteins activated by the TGF-beta signaling pathway, Smad2 and Smad3, do not bind with significant affinity. Functional studies using the muscle creatine kinase (MCK) promoter, which is suppressed by BMP signaling, demonstrate that Suv39h proteins and Smads cooperate to repress promoter activity. These data suggest a model where association of Smad proteins with Suv39h methyltransferases can repress or silence genes involved in developmental processes, and argues that inefficient gene repression may result in the alteration of the differentiated phenotype. Thus, examination of the Smad-Suv interaction may provide insight into the mechanism of phenotypic determination mediated by BMP signaling.Oncogene 08/2004; 23(30):5242-51. · 8.56 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: During vascular development, nascent endothelial networks are invested with a layer of supporting cells called pericytes in capillaries or smooth muscle in larger vessels. The cellular lineage of smooth muscle precursors and factors responsible for regulating their differentiation remain uncertain. In vivo, cells derived from the multipotent neural crest can give rise to vascular smooth muscle in parts of the head and also the cardiac outflow tract. Although transforming growth factor-beta (TGF-beta) has previously been shown to induce some smooth muscle markers from primary cultures of neural crest stem cells, the extent of the differentiation induced was not clear. In this study, we demonstrate that TGF-beta can induce many of the markers and characteristics of vascular smooth muscle from a neural crest stem cell line, Monc-1. Within 3 days of in vitro treatment, TGF-beta induces multiple smooth muscle-specific markers, while downregulating epithelial markers present on the parent cells. Treatment with TGF-beta also induces a contractile phenotype that responds to the muscarinic agonist carbachol and is not immediately reversed on TGF-beta withdrawal. Examination of the signaling pathways involved revealed that TGF-beta activation of Smad2 and Smad3 appear to be essential for the observed differentiation. Taken together, this system provides a novel model of smooth muscle differentiation that reliably recapitulates the process observed in vivo and allows for dissection of the pathways and processes involved in this process.Circulation Research 06/2004; 94(9):1195-202. · 11.09 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) receptors and regulate transcription of target genes. TGF-beta is implicated in the regulation of the smooth muscle cell specific gene SM22alpha, but little is known about how Smads are involved in SM22alpha gene transcription. In this report, we demonstrate that TGF-beta activation of the SM22alpha promoter is Smad dependent in C3H10T1/2 cells, BALB 3T3 cells and neural crest Monc-1 cells. We find that the promoter region from -162 to +41 is sufficient to up-regulate the reporter gene upon TGF-beta induction. Smad3, Smad1 and Smad4 are found in TGF-beta inducible complexes that bind to a region containing a Smad binding site (SBS) and a medea box. Both the SBS and medea box are necessary for complex formation and are functionally important. Smad4 is limiting for TGF-beta induction, and Smad3, but not Smad1, significantly contributes to maximal activation. Time course luciferase assays and time course gel mobility shift assays reveal that the Smad3/4 complex is largely responsible for the immediate response of the SM22alpha promoter to TGF-beta induction, and also contributes to the maximal promoter activity. We further demonstrate that AP-1 elements contribute to induction of the SM22alpha promoter by TGF-beta.Nucleic Acids Research 03/2003; 31(4):1302-10. · 8.81 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The intracellular signaling events of the bone morphogenetic proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding transcriptional modulators and shown to recruit the master transcriptional co-activator CBP/p300 for transcriptional activation. SNIP1 is a recently discovered novel repressor of CBP/p300. Currently, the detailed molecular mechanisms that allow R-Smads and Co-Smad to co-operatively modulate transcription events are not fully understood. Here we report a novel physical and functional link between Smad1 and the 26S proteasome that contributes to Smad1- and Smad4-mediated transcriptional regulation. Smad1 forms a complex with a proteasome beta subunit HsN3 and the ornithine decarboxylase antizyme (Az). The interaction is enhanced upon BMP type I receptor activation and occur prior to the incorporation of HsN3 into the mature 20S proteasome. Furthermore, BMPs trigger the translocation of Smad1, HsN3 and Az into the nucleus, where the novel CBP/p300 repressor protein SNIP1 is further recruited to Smad1/HsN3/Az complex and degraded in a Smad1-, Smad4- and Az-dependent fashion. The degradation of the CBP/p300 repressor SNIP1 is likely an essential step for Smad1-, Smad4-mediated transcriptional activation, since increased SNIP1 expression inhibits BMP-induced gene responses. Our studies thus add two additional important functional partners of Smad1 into the signaling web of BMPs and also suggest a novel mechanism for Smad1 and Smad4 to co-modulate transcription via regulating proteasomal degradation of CBP/p300 repressor SNIP1.BMC Cell Biology 07/2002; 3:15. · 2.84 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The zebrafish mutant violet beauregarde (vbg) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells flow through a limited number of dilated cranial vessels and fail to perfuse the trunk and tail. This phenotype cannot be explained by caudal vessel abnormalities or by a defect in cranial vessel patterning, but instead stems from an increase in endothelial cell number in specific cranial vessels. We show that vbg encodes activin receptor-like kinase 1 (Acvrl1; also known as Alk1), a TGFbeta type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants. Thus, vbg provides a model for the human autosomal dominant disorder, hereditary hemorrhagic telangiectasia type 2, in which disruption of ACVRL1 causes vessel malformations that may result in hemorrhage or stroke. Movies available on-lineDevelopment 07/2002; 129(12):3009-19. · 6.27 Impact Factor - genesis 03/2002; 32(2):76-9. · 2.04 Impact Factor
- genesis 02/2002; 32(2):76-79. · 2.04 Impact Factor
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ABSTRACT: The Smad family of intracellular signaling intermediates transduce signals downstream from the transforming growth factor beta (TGF-beta) family of receptor serine threonine kinases. The original member of this family, Smad1, has been shown to mediate signals from receptors for the bone morphogenetic proteins (BMPs), a large group of ligands in the TGF-beta superfamily that mediate important developmental events. We have targeted the Smad1 gene in mice and created mutants null at this locus. Smad1 mutant mice die at approximately 9.5 days postcoitum due to defects in allantois formation. In Smad1 mutant mice, the allantois fails to fuse to the chorion, resulting in a lack of placenta and failure to establish a definitive embryonic circulation. Although vasculogenesis is initiated in the mutant allantois, the vessels formed are disorganized, and VCAM-1 protein, a marker for distal allantois development, is not expressed. Smad1 null fibroblasts are still able to respond to BMP2, however, suggesting that the defect observed in the developing extraembryonic tissue is caused by a very specific loss of transcriptional activity regulated by Smad1. Our data further demonstrate that although highly similar structurally, Smad proteins are not functionally homologous.Developmental Biology 01/2002; 240(1):157-67. · 3.64 Impact Factor -
Article: Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner.
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ABSTRACT: Smad proteins transduce signals from TGF-beta receptors and regulate transcription of target genes either directly or in combination with other sequence-specific transcription factors. AP-1 sites and their cognate transcription factors also play important roles in the gene regulatory activities of TGF-beta. In this report, we have investigated the functional interactions of the Smad and AP-1 transcription factors. We demonstrate that Smad and AP-1 complexes specifically bind to their cognate cis-elements and do not interact with each other on-DNA, whereas off-DNA interactions occur between Smad3 and both c-Jun and JunB. Using both artificial constructs specific for either the Smad or AP-1 signaling pathways or natural promoters known to be TGF-beta-responsive, we have determined that Jun family members downregulate Smad3-mediated gene transactivation whereas AP-1-dependent promoters are synergistically activated by Smad3 and Jun proteins. We propose a model where the presence of Smad- and/or AP-1-specific cis-elements within TGF-beta-responsive genes allows dynamic modulation of gene expression, in contrast to the existing model where interactions between Smad and AP-1 proteins are merely an on/off mechanism to regulate TGF-beta/Smad targets.Oncogene 07/2001; 20(26):3332-40. · 8.56 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Members of the transforming growth factor-beta (TGF-beta) superfamily signal through unique cell membrane receptor serine-threonine kinases to activate downstream targets. TRAP1 is a previously described 96-kDa cytoplasmic protein shown to bind to TGF-beta receptors and suggested to play a role in TGF-beta signaling. We now fully characterize the binding properties of TRAP1, and show that it associates strongly with inactive heteromeric TGF-beta and activin receptor complexes and is released upon activation of signaling. Moreover, we demonstrate that TRAP1 plays a role in the Smad-mediated signal transduction pathway, interacting with the common mediator, Smad4, in a ligand-dependent fashion. While TRAP1 has only a small stimulatory effect on TGF-beta signaling in functional assays, deletion constructs of TRAP1 inhibit TGF-beta signaling and diminish the interaction of Smad4 with Smad2. These are the first data to identify a specific molecular chaperone for Smad4, suggesting a model in which TRAP1 brings Smad4 into the vicinity of the receptor complex and facilitates its transfer to the receptor-activated Smad proteins.Journal of Biological Chemistry 07/2001; 276(22):19495-502. · 4.60 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Sorting nexins (SNX) comprise a family of proteins with homology to several yeast proteins, including Vps5p and Mvp1p, that are required for the sorting of proteins to the yeast vacuole. Human SNX1, -2, and -4 have been proposed to play a role in receptor trafficking and have been shown to bind to several receptor tyrosine kinases, including receptors for epidermal growth factor, platelet-derived growth factor, and insulin as well as the long form of the leptin receptor, a glycoprotein 130-associated receptor. We now describe a novel member of this family, SNX6, which interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.Journal of Biological Chemistry 07/2001; 276(22):19332-9. · 4.60 Impact Factor -
Article: A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
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ABSTRACT: Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.Nature Cell Biology 01/2001; 2(12):915-21. · 20.06 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Members of the transforming growth factor-beta superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-beta family ligands are mediated by Smad proteins. To understand the mechanism of Smad function, we sought to identify novel interactors of Smads by use of a yeast two-hybrid system. A 396-amino acid nuclear protein termed SNIP1 was cloned and shown to harbor a nuclear localization signal (NLS) and a Forkhead-associated (FHA) domain. The carboxyl terminus of SNIP1 interacts with Smad1 and Smad2 in yeast two-hybrid as well as in mammalian overexpression systems. However, the amino terminus of SNIP1 harbors binding sites for both Smad4 and the coactivator CBP/p300. Interaction between endogenous levels of SNIP1 and Smad4 or CBP/p300 is detected in NMuMg cells as well as in vitro. Overexpression of full-length SNIP1 or its amino terminus is sufficient to inhibit multiple gene responses to TGF-beta and CBP/p300, as well as the formation of a Smad4/p300 complex. Studies in Xenopus laevis further suggest that SNIP1 plays a role in regulating dorsomedial mesoderm formation by the TGF-beta family member nodal. Thus, SNIP1 is a nuclear inhibitor of CBP/p300 and its level of expression in specific cell types has important physiological consequences by setting a threshold for TGF-beta-induced transcriptional activation involving CBP/p300.Genes & Development 08/2000; 14(13):1605-16. · 12.64 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The MSG1 nuclear protein has a strong transcriptional activating activity but does not bind directly to DNA. When cotransfected, MSG1 enhances transcription mediated by the Smad transcription factors in mammalian cells in a manner dependent on ligand-induced Smad hetero-oligomerization. However, the mechanism of this MSG1 effect has been unknown. We now show that MSG1 directly binds to the p300/cAMP-response element-binding protein-binding protein (CBP) transcriptional coactivators, which in turn bind to the Smads, and enhances Smad-mediated transcription in a manner dependent on p300/CBP. The C-terminal transactivating domain of MSG1 is required for binding to p300/CBP and enhancement of Smad-mediated transcription; the viral VP16 transactivating domain could not substitute for it. In the N-terminal region of MSG1, we identified a domain that is necessary and sufficient to direct the specific interaction of MSG1 with Smads. We also found that the Hsc70 heat-shock cognate protein also forms complex with MSG1 in vivo, suppressing both binding of MSG1 to p300/CBP and enhancement of Smad-mediated transcription by MSG1. These results indicate that MSG1 interacts with both the DNA-binding Smad proteins and the p300/CBP coactivators through its N- and C-terminal regions, respectively, and enhances the functional link between Smads and p300/CBP.Journal of Biological Chemistry 04/2000; 275(12):8825-34. · 4.60 Impact Factor
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15 Trendy DIY Color Block Crafts For Home Décor
Color blocking is an extremely popular trend, you can see it everywhere from home décor to weddings. We've rounded up the coolest color blocking tutorials of furniture and décor pieces to make your home super trendy in just a few steps! Color blocking is super easy: just choose some color that you love and buy paint or... More
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A bit of light reading and information broadcasting
Many organizations have achieved complete network visibility and better security with the Beacon product suite. If you'd like a sharper picture of how we can enhance your network and overall organizational experience, look no further.
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Dr. David W. Amory, MD
Orthopaedic Surgery, Orthopaedics Specialists Of North County
- 6121 Paseo Del Norte Ste 200
Carlsbad, CA 92011 - 2 Office Locations
- (760) 724-9000
Dr. David W. Amory graduated from the Tulane University School of Medicine in 1991. He works in Carlsbad, CA and 1 other location and specializes in Orthopaedic Surgery. Dr. Amory is affiliated with Tri-City Medical Center and Scripps Hospital Encinitas. He speaks English and Spanish.
Gender: Male
Years in Practice: 24 Years
Languages Spoken: English, Spanish
Medical School: Tulane University School of Medicine
Graduation Date: 1991
Hospital Affiliations: Tri-City Medical Center, Scripps Hospital Encinitas
Specialties: Orthopaedic Surgery
*This physician has multiple office locations. See Appointments for details.


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Funeral services for Olympia Charmaine Coleman, 36, were held at 11 a.m., February 27 at Gospel Temple Cogic in Ackerman. Elder Ethen Gillespie officiated. Burial followed… Read more
Letter to the editor – Ramblin with Arlene
Praise the Lord everyone. God is so good and so worthy of all our praises. He is working in so many ways all around us. If we could only open our spiritual eyes and be … Read more
Alice Faye Farish Iverlett
Alice Faye, 68, passed away on Feb. 26, 2014 at her home on Center Hill Lake in Smithville.
She was born Oct. 12, 1945 in Philadelphia, MS, to the proud parents, Robert and Dorothy Farish of Noxapater, MS.
She grew … Read more
Mr. Arlon "Pete" Fulton
Funeral services for Mr. Arlon "Pete" Fulton will be held at 3 PM Thursday, March 6, 2014 from Spring Creek Baptist Church with… Read more
Richard H. Woodward
Mr. Richard H. Woodward, 54, died Friday, February 28, 2014, at Pioneer Community Hospital in Ackerman, MS. Funeral services were held at 11:00 A.M. Monday, March 3rd, at … Read more
Christene Hannah
Ms. Christene Hannah, 76, died Thursday, February 20, 2014 at home with her family. Ms. Hannah was born January 12, 1938, in Louisville, MS. She was a retired in-home healthcare provider, and a member of the McCool Church of God.… Read more


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US 4098767 A Abstract A new class of copolymers obtained via copolymerizing diethynylbenzene with an ethynyl substituted polyimide oligomer has been developed. The copolymers are thermosetting in character and are particularly useful for the fabrication of composite structures such as glass fiber reinforced laminates and molding compounds and graphite fiber reinforced laminates and molding compounds having zero void content.
Claims(6) 1. Composite materials prepared from copolymers comprised of an ethynyl-substituted polyimide oligomer comprised of the following general structure ##STR5## n=0 to 5, m=0 to 5, and
x=O, S, CH2, CO, SO2 coreacted with less than 20% of a di- or polyethynyl-substituted diluent and a reinforcing fabric, filler or chopped fiber. 2. A new class of copolymers comprised of less than 20% by weight of a di- or polyethynyl-substituted diluent coreacted with an ethynyl substituted polyimide oligomer comprised of the following general structure ##STR6## n=0-5, m=0-5, and
x=O,S, CH2, CO, SO2. 3. The copolymer of claim 2 wherein "n" is 2, "m" is 0, and said diluent is diethynylbenzene.
4. The copolymer of claim 2 wherein "n" is 2, "m" is 0, and said diluent is diethynyldiphenyl ether.
5. The material of claim 1 wherein "n"is 2, "m" is 0, and said diluent is diethynylbenzene.
6. The material of claim 1 wherein "n" is 2, "m" is 0, and said diluent is diethynyldiphenyl ether.
Description The invention herein described was made in the course of or under a contract or subcontract thereunder with the Department of the Air Force. In U.S. application Ser. No. 413,473, filed Nov. 6, 1973, by applicant and others and now issued as U.S. Pat. No. 3,845,018, a new class of ethynyl substituted polyimide oligomers which cure by addition is disclosed. The present invention utilizes oligomers of the class disclosed in U.S. Pat. No. 3,845,018 to form copolymers having superior physical and mechanical properties when compared to other polyimide polymers and/or copolymers. 1. Field of the Invention This invention may be classified as one relating to the preparation and formulation of polyimide polymers and copolymers. 2. Description of Prior Art Composite materials have been used extensively as structural materials in aerospace and other applications where high strength, light weight materials capable of withstanding high temperatures are required. Considerable efforts to extend the thermal stability range, while retaining good structural strength without increasing the weight of such materials has been expanded. Currently, addition polymers such as epoxy resins are used in conjunction with fibers or fabrics to provide essentially void free composite structures which exhibit good structural properties and are light in weight. These structures, however, are limited in their use temperatures to about 150�-175� C because of the thermal stability characteristics of expoxy resins. There are polyimides such as "P13N" from Ciba Geigy Corporation which give very low void content laminates which are useful at temperatures up to 288� C and there is a polyimide known as Kerimid 601 from Rhodia Corporation (a subsidiary of Rhone Poulenc Co.) which can provide void free laminates which can withstand temperatures of up to 260� C. Higher temperature laminating resins which cure through addition were unknown prior to the development of the polyimides No. described in the Hughes Aircraft Company U.S. Pat. No. 3,845,018, although there are condensation type polyimides which can be used to produce laminates which withstand temperatures up to 300�-320� C. These resins are limited in their usefulness because the laminates and/or composite materials produced from them exhibit void contents as high as 20-40%. The voids are primarily caused by outgassing which occurs during the condensation mechanism cure. Applicant herein, in conjunction with Drs. A. J. Landis and L. J. Miller of Hughes Aircraft Company, developed acetylene substituted polyimide oligomers which cure through addition rather than condensation in an attempt to solve the void problem discussed above and retain good thermal resistant properties. Polyimide composites with as little as several tenths to 1% voids were obtained even when molding pressures as low as 200 psi were used. These materials are described in U.S. Pat. No. 3,845,018. Applicant's present invention constitutes a substantial improvement over the invention described in U.S. Pat. No. 3,845,018 as well as the prior art in that it facilitates the preparation of laminates and composites having high thermal stability, zero void content, and better mechanical properties because of the lower viscosity imparted by the incorporation of the reactive diluent. This is especially true in applications where inpregnation of the oligomer into a highly porous substrate is important. Applicant has found that copolymers of diethynylbenzene and other di- or poly ethnyl-substituted diluents and an ethynylated polyimide oligomer such as one having the following general structure ##STR1## and wherein n = 0 to 5 m = 0 to 5 and x = O, S, CH2, CO, SO2 can be prepared which, when used to prepared fabricated laminates and other composite structures, result in void free structures having high thermal resistance with excellent mechanical properties. My invention is a new composition of matter formed via the copolymerization of di- or polyethynyl-substituted diluents such as diethynylbenzene or diethynyldiphenyl ehter with ethynyl substituted polyimide oligomers. One purpose of the invention is to provide a class of heat resistant copolymers which are thermosetting. A second purpose is to provide a class of heat resistant copolymers which cure through addition rather than through condensation. A third purpose is to provide thermosetting addition polymers which have sufficiently low viscosity to exhibit good melt flow characteristics, good molding properties and good coating characteristics, and a fourth purpose is to provide thermosetting resins which, when used in the fabrication of composite structures, yield cured resin matrices having very low or zero void contents. This latter purpose is very important since composite structures without voids can exhibit the optimum potential properties characteristic of their constituents. I have discovered that the incorporation of diethynylbenzene and analogous copolymerizable acetylene substituted diluents in a polyimide oligomer such as one having the following structure ##STR2## wherein x, n, and m are as defined previously, will yield products which allow me to produce laminates with essentially zero void contents, and such laminates are considerably stronger than analogous laminates with larger void contents. In the specific case where n = 2 and m = 0, the oligomer is one which I call HR600. This is the one which was used in several of my experiments. The advantage of this invention is largely attributed to the fact that my copolymer was produced from a polyimide oligomer and a liquid compound which could effectively interact with it during cure. The liquid effectively thins out the oligomer when the oligomer is heated and molded and allows the molten oligomer to flow readily into the pores and crevices in fillers and fabric reinforcements. Upon cure, the "thinner" coreacts with the oligomer and thus it doesn't have to be removed from the resin as an ordinary solvent wouuld have to be. The coreaction between the thinner and the oligomer during cure also yields a product with a higher cross link density than that which the cured oligomer alone would have. With HR600, the copolymers of this invention can be visualized as being formed as follows: ##STR3## Although the whole molecule is not illustrated, this partial structure adequately illustrates the high degree of complexity of the copolymers. Nuclear magnetic resonance spectroscopy supports the belief that cure occurs when aromatic rings are formed from the acetylene substituted polyimides. However, absolute proof of this theory has not been obtained and it may be that some other types of functional groups such as cyclobutadiene groups or bi-ethynyl groups might also be present to some degree. Nevertheless, the HR600 and diethynylbenzene obviously copolymerize as evidenced by the void free composite structure obtained when a laminate was made. One copolymer of this invention can be produced by mixing diethynylbenzene with the ethynyl substituted polyimide oligomer. It is important, however, to avoid the use of excess diethynylbenzene since this compound can polymerize explosively. I thus prefer using less than 20% by weight of the diethynylbenzene in the oligomer. It is possible to pre-react these materials by careful heating of the mixtures at temperatures of about 400�-450� F, but prepolymerization is not essential since the oligomer can merely be diluted with the diethynylbenzene and used directly as a molding or laminating resin. Various other di- or polyethynyl-substituted diluents could also function in this capacity. A specific example of how my copolymer may be prepared within the matrix of a laminate is described below. A section of glass cloth (181E glass having an A-1100 finish) was cut to 10 � 18 inches and then weighed. A quantity of powered HR600 was then weighed out sufficient to provide a 40% resin weight pick up on the fabric. To this amount of resin was added N-methylpyrrolidone, producing a coating varnish after heating the mixture to 325� F to promote dissolution. The glass fabric was dipped into, and slowly pulled through the hot solution in a dip tank at 350� F. The coating process was repeated until all of the varnish was consumed; however, the fabric was air dried for 30 minutes followed by 15 minutes at 350� F. after each coating. Subsequently the coated fabric was dried for 16 hours under vacuum at 160� F. Next it was cut in half, and 1 half was made into a 6 ply laminate by molding it at 485� F and 200 p.s.i. using a contact time of 90 seconds and a cure time of 2 hours. The other half of the fabric was brushed with a solution of diethynylbenzene (DEB) in hexane (20 ml.). Sufficient DEB was used so that its weight was equal to 10% of the HR600 resin weight. After a 5 minute air dry the coated "prepreg" fabric was placed into a "Teflon" film bag and the bag was sealed and stored for 7 days. After aging the fabric, a laminate was molded at 485� F and 200 p.s.i. using a contact time of 90 seconds and a cure time of 2 hours. A comparison of the properties of these two laminates showed the following: ______________________________________ WithoutProperty DEB With DEB______________________________________Thickness 0.050" 0.045"Density 1.91 g/cc 2.11 g/ccResin Content 23.0% 24.1%Void Content 5.0% 0%______________________________________ Void content calculations were based on a density of 1.40 g/cc for the HR600 resin and 2.51 g/cc for the glass fabric. The difference between the two laminates was startling since under the specific molding conditions used the laminate without DEB had 5% voids and the laminate with DEB had 0% voids. Other molding conditions would show a different differential. The advantage of adding DEB was even more evident when a comparison was made between the physical properties of the DEB containing laminate and several other HR600/181E glass laminates that had been fabricated earlier and tested previously. Results of this comparison are shown below __________________________________________________________________________ Flexural Flexural Void Strength Modulus,Laminate No. Content p.s.i. at 550� F. p.s.i. at 550� F.__________________________________________________________________________G 1996-31 3.5 26.5 � 103 1.25 � 106(no DEB)G 1996-22B 1.4 28.5 � 103 1.95 � 106(no DEB)With DEB/HR600 0 34.5 � 103 2.40 � 106__________________________________________________________________________ A chloroform solution of HR700 oligomer (whose structure is shown below) was mixed with sufficient diethynylbenzene (DEB) ##STR4## such that the oligomer DEB weight ratio was 10 to 1 and the mixture was poured into a small crystallizing dish. After the chloroform had evaporated, the oligomer mixture was pulverized and molded with heating at a pressure of 200 p.s.i. Microscopic examination of the cured resin showed no evidence of porosity. Having described my invention with sufficient particularity so as to let one know what is intended, the scope of my claims may now be understood as follows. Patent Citations
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On this installment, a topless woman is found in a park. She's hanging by bondage cuffs and covered in caramel sauce. From there, Castle and Beckett are off to the underground world of sexual domination.
Is the killer somewhere there?
Castle: Did you just use the word "veritable" in a sentence?
Beckett: Yes, I did.
Castle: Sexy!
Beckett: You should hear me say "fallacious."
- Permalink: Did you just use the word veritable in a sentence? Yes, I did....
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Castle:Alright, what aren't you telling me!?
Beckett:Oh so much Castle, so very very much.
- Permalink: Alright, what aren't you telling me!? Oh so much Castle, so ver...
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Happy Saturday, folks! Did you hear? Mitt Romney has announced his running mate for the presidential election — Congressman Paul Ryan (R-WI). Let's get to know him, shall we? Keep reading »
Zergnet: Simply Irresistible
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Happy Saturday, folks! Did you hear? Mitt Romney has announced his running mate for the presidential election — Congressman Paul Ryan (R-WI). Let's get to know him, shall we? Keep reading »
This morning, as the dull ache of cramps woke me from my slumber, I realized something kind of momentous. I have had my period for exactly 20 years. I mean, almost exactly, because I don't know the exact date or time that my Aunt Flow first came to visit, but I do know it was at the beginning of the school year, before I turned 13. I turn 33 in November, so, yep, that makes for 20 bloody years. That's a lot of tampons. Over the years, I've learned a few things about myself specifically in relation to tampons and their usage. Let me share them with you. Keep reading »
I want to climb into the womb of "TLC" and live there forever. The network really, really gets it. Um, did anyone see the preview for "Abby & Brittany," the new reality show about the conjoined twins? Holy crap, TLC. I bow down. Anyhow, last night's two-episode premiere of "Here Comes Honey Boo Boo" was more epic than I expected. Not only were most of my pressing questions answered, but I learned things I never expected to know in this lifetime. Bless you, Boo Boos, for how you've enriched my life. This is definitely my new favorite show. Bottom line. Here are the six very important things you might have missed on last night's episodes of "Here Comes Honey Boo Boo." Be prepared to have your mind blown. (Plus! Bonus clips of Alana on a new episode of "Toddlers and Tiaras," which also aired last night.) Keep reading »
We all go through dry spells. We all know what it's like. So let's give ourselves permission to laugh about those moments when you realize it has been entirely too long since you last had sex. Here are 15 signs. Keep reading »
Big tits and August don't mix. In this hot hot heat, sweating bullets could kill your good looks, no thanks to gross breast sweat. I once had a dude dip a finger in my cleavage on a 100-degree day only to retract his hand in horror. Oh strapless bra, you sold me down a river, literally! But since then, I've learned to beat the heat and you can too. So, don't let your melons become watermelons this summer. Save yourself with these tips… Keep reading »


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GTA: San AndreasAMAZING GTA SA HYDRA JET STUNT MONTAGE! 'VENGEANCE' -Throwback (youtu.be)
submitted by Original_Vauny
GTA: San AndreasIs there a fix for cars braking with the frame limiter off? (self.GTA)
submitted by OlSom
GTA 5Ron Paul Warned Us' Derby [Grand Theft Auto V Crew Event] (youtube.com)
submitted by hairybones1997
GTA 5[GTA V] Demanding COMPENSATION for every single player [GTA O] (self.GTA)
submitted by noahlauzier


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Q: Explain how you work with both tenants and property owners at Soto Property Management.
A: When someone decides to take advantage of all the financial benefits of owning rental property and either doesn't want to or doesn't have the time to handle the day-to-day task of taking care of that property, they turn the management over to us. We take care of everything you could possibly imagine. Preparing a vacant property for a new tenant, finding a tenant, collecting the rent and taking care of any issues regarding that property and more. I like to tell my clients that their only job is to open the e-mail that I send them once a month telling them that their statement has been uploaded to our website and their funds have been deposited into their bank account. We are a real estate company so we can and do work with investors in finding property to add to their portfolio. That being said, the majority of our face time is with tenants or prospective tenants. We view our tenants as our customers and treat them with respect and do everything we can to provide them with a safe, comfortable and enjoyable place to live.
Q: When did you start this company and why?
A: I actually didn't start the company; rather I bought Wunderlich Realty and Property Management from Clinton and Doris Wunderlich. Doris still works for the company, bringing many years' experience with her. We closed the deal in June 2008. I decided that I had enough working for a large corporation and I wanted to control my own destiny. I find the real estate business much more enjoyable than the computer service industry.
Q: Tell me about your background and experience in the real estate business.
A: I've been a real estate investor for about 10 years. When I first started, I realized that it wasn't something I could do on my own so I hired a property management company, which I ended up buying. I got my real estate license about the same time. In order to keep your license you have to regularly attend continuing education. For my continuing education, I chose as many property management classes as I could. My background is in the computer service industry and the parallels between the two businesses are remarkable. I knew that I could apply my experience in computer service management in this business.
Q: What kind of person invests in real estate? Tell us about your clients.
A: Our clients are regular people who've decided to invest some of their money into real estate instead of stocks or mutual funds. They may invest in those too, but realize the advantages of owning real estate. Some of our clients are right here in this area and some are from different parts of the country. We even have one client from Saudi Arabia. They all have chosen to invest their money right here in Southeast Missouri.
Q: What advice would you give to someone who is interested in investing in rental property?
A: First of all, to get an education. I'm not talking about those late night infomercials; I'm talking about the many books, websites and podcast that are available that teach actual real estate investing. I've seen people who have jumped into this thinking that this is easy and have failed. If you've heard horror stories about rental property; these are more than likely the people you've heard it from. Second would be to understand that this is a business and treat it as such. Have a business plan, make sure to do a financial analysis and stick to it. Do your due diligence. And finally, surround yourself with knowledgeable professionals. Don't try to do this on your own. Even if you turn the management over to a company like ours it is critical to learn this business. Investing in real estate can be very rewarding financially, but only if it's done properly.
Q: Tell me about your work with the Missouri Association of Realtors.
A: I'm on two committees at the state level. Both are legislative and regulatory related. These committees monitor and recommend proposed state legislation, and we analyze its impact on home ownership in the state of Missouri. I'm also vice chair of the MARs property management section, and locally I'm a director on the Cape Girardeau County Board of Realtors Multiple Listing Service, and I'm president elect for the Southeast Missouri chapter of Women's Council of Realtors. I think if you're going to be in an industry, you need to be involved in the industry.
Q: With Southeast Missouri State University starting classes soon, have you been renting a lot of apartments to students?
A: Actually the students start inquiring about available rentals starting around May. Activity picks up in July and continues even into September. We enjoy working with the students, but they are a small percentage of our tenants.
Q: With the current economic conditions, are you having trouble keeping rental properties occupied?
A: Surprisingly we've only lost a few tenants who have had to move because they couldn't afford the higher rent, and when we can, we'll find them another property with lower rent. Overall our vacancy rate has remained consistent over the last few years.
Q: Tell me about your other community involvements here in Cape Girardeau.
A: I'm a true believer in giving back. I've been blessed in many ways and I try to contribute as much as I can. With my busy schedule the only time I have to give, I give to the Kiwanis in Jackson where I'm a member. I do give to different charities. Charity is actually a line item in my budget. I'm being locked up for MDA this month. I have a pretty aggressive goal of how much I need to raise. I hope I can achieve it.


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dc.contributor.advisor | Howard J. Herzog. | en_US |
dc.contributor.author | Bohm, Mark (Mark C.) | en_US |
dc.contributor.other | Massachusetts Institute of Technology. Technology and Policy Program. | en_US |
dc.date.accessioned | 2006-11-07T12:42:47Z | |
dc.date.available | 2006-11-07T12:42:47Z | |
dc.date.copyright | 2006 | en_US |
dc.date.issued | 2006 | en_US |
dc.identifier.uri | http://hdl.handle.net/1721.1/34517 | |
dc.description | Thesis (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2006. | en_US |
dc.description | Includes bibliographical references (p. 93-95). | en_US |
dc.description.abstract | A plant can be considered to be capture-ready if, at some point in the future it can be retrofitted for carbon capture and sequestration and still be economical to operate. The concept of capture-ready is not a specific plant design; rather it is a spectrum of investments and design decisions that a plant owner might undertake during the design and construction of a plant. Power plant owners and policymakers are interested in capture-ready plants because they may offer relatively low cost opportunities to bridge the gap between current coal-fired generation technologies without CO2 capture to future plants that may be built from the start to capture CO2, and reduce the risks of possible future regulations of CO2 emissions. This thesis explores the design options, technologies and costs of capture-ready coal-fired power plants. The first part of the thesis outlines the two major designs that are being considered for construction in the near-term - pulverized coal (PC) and integrated gasification/combined cycle (IGCC). It details the steps that are necessary to retrofit each of these plants for CO2 capture and sequestration. Finally, for each technology, it provides a qualitative assessment of the steps that can be taken to reduce the costs and output de-rating of the plant after a retrofit. | en_US |
dc.description.abstract | (cont.) The second part of the thesis evaluates the lifetime (40 year) net present value (NPV) costs of plants with differing levels of pre-investment for CO2 capture. Three scenarios are evaluated - a baseline supercritical PC plant, a baseline IGCC plant and an IGCC plant with pre-investment for capture. This analysis evaluates each technology option under a range of CO2 tax scenarios and determines the most economical choice and year of retrofit. The results of this thesis show that a baseline PC plant is the most economical choice under low CO2 tax rates, and IGCC plants are preferable at higher tax rates. Little difference is seen in the lifetime NPV costs between the IGCC plants with and without pre-investment for CO2 capture. The third part of this thesis evaluates the concept of CO2 "lock-in". CO2 lock-in occurs when a newly built plant is so prohibitively expensive to retrofit for CO2 capture that it will never be retrofitted for capture, and offers no economic opportunity to reduce the CO2 emissions from the plant, besides shutting down or rebuilding. The results of this analysis show that IGCC plants are expected to have significantly lower lifetime CO2 emissions than a PC plant, given moderate (10-35 $/ton CO2) initial tax rates. | en_US |
dc.description.abstract | (cont.) Higher (above $40) or lower (below $7) initial tax rates do not result in significant differences in lifetime CO2 emissions from these plants. Little difference is seen in the lifetime CO2 emissions between the IGCC plants with and without pre-investment for CO2 capture. | en_US |
dc.description.statementofresponsibility | by Mark Bohm. | en_US |
dc.format.extent | 99 p. | en_US |
dc.format.extent | 4371818 bytes | |
dc.format.extent | 4375914 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | en_US |
dc.publisher | Massachusetts Institute of Technology | en_US |
dc.rights | M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. | en_US |
dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | |
dc.subject | Technology and Policy Program. | en_US |
dc.title | Capture-ready power plants : options, technologies and economics | en_US |
dc.type | Thesis | en_US |
dc.description.degree | S.M. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Technology and Policy Program. | en_US |
dc.identifier.oclc | 70900723 | en_US |
Name | Size | Format | Description |
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text:
Kastet, Worrel
Lacey Kastet and Joseph Worrel, both Adrian, N.D., announce their engagement and forthcoming marriage.
Parents of the couple are Amy and Duane Kastet, Ypsilanti, N.D., and Laura and Steven Van Asperen, Ypsilanti, and Scot Worrel, LaMoure, N.D.
Lacey's grandparents are Glenice Kastet, Ypsilanti, and the late Leroy Kastet, and the late Rose Marie and Jack Nihill.
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2006 Hanzell Sonoma Valley Chardonnay
15.0% alc., 3,253 cases. Severe frost in March led to limited yields. Temperatures in the second half of July soared, peaking at 114ºF. 50% of wine was barrel fermented in this vintage. Aged 18 months in one-third new Sirugue French oak barrels. Michael Terrien winemaker. · Moderately deep golden straw color and clear in the glass. Aromas of poppyseed, lemon, vanilla, old book and flint. Modest fullness and creaminess (alcohol-driven) with good vim, offering flavors of lemon curd, honey, yellow peach and marzipan. Finishes with a hint of warmth on the finish. Drink or hold. Score: 88. Reviewed July 21, 2013
Winery: Hanzell Vineyards From article: Hanzell: Still Quality, Character and Reverence After 50 Years


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International Building Code 2009SOFTCOVER VERSION: Featuring time-tested safety concepts and the very latest industry standards in material design, the 2009 International Building Code? offers up-to-date, comprehensive insight into the regulations surrounding the design and installation of building systems. It provides valuable structural, fire-, and life- safety provisions that cover means of egress, interior finish requirements, roofs, seismic engineering, innovative construction technology, and occupancy classifications. This content is developed in the context of the broad-based principles that facilitate the use of new materials and building designs, making this an indispensable reference guide for anyone seeking a strong working knowledge of building systems. |
What people are saying - Write a review
Change is comin' this way.
User Review - gpdx - Overstock.comIt's a good price instead of paying full at the regular bookstore, and everyone wants the binder version to insert your local building codes. Get it now before it gets too hot. Easy to spot most of the changes from 2003. ... Read full review
Review: International Building Code 2003
User Review - Tobin Faucheux - GoodreadsRead in part only. Read full review
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accor accordance with Section applied approved area of refuge automatic sprinkler system braced wall line building official building or structure ceiling Chapter combustible comply with Section concrete constructed in accordance corridors dampers deep foundation doors ducts dwelling units elevator exceed Exception exit access exterior wall facilities fastened fire alarm fire barriers fire-resistance rating fire-resistance-rated floor foot framing gage glazing grade plane Group hazard height horizontal assemblies inches installed in accordance insulation interior International Fire Code International Mechanical Code joints joist less light-frame construction live load located materials maximum means of egress metal minimum nails NFPA noncombustible occupant load openings PC PC PC percent permitted plaster protection reinforcement requirements of Section resist rooms Seismic Design Category shear shear wall sheathing sleeping units slope smoke detectors spaces special inspection Specification square feet stairway Standard steel storage studs surface Table thickness tion Type vertical wallboard width


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By Sport
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Pam Shriver - All Columnists
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9 results for "maria sharapova"
Serena a favorite going forward
Pam ShriverSerena Williams won her eighth Grand Slam title in dominating fashion at the Australian Open. Pam Shriver writes how Williams proved she's the best total package in the game.
Story | Conversation | January 26, 2007 -
It's great to see Venus back
Pam ShriverPam Shriver's previews and picks for the women's semis at Wimbledon.
Story | Conversation | June 28, 2005 -
Serena has no intention of losing a third matchup
Pam ShriverSerena doesn't like to lose three matches in a row to anybody, so Sharapova probably won't reach the final.
Story | Conversation | January 24, 2005 -
Sharapova wins despite Serena's brave effort
Pam ShriverThe WTA Tour Championships final ended with another Russian winning and Serena Williams injured again.
Story | Conversation | November 15, 2004 -
If healthy, Serena should win title
Pam ShriverSerena Williams struggled, Maria Sharapova jumped onto the scene and Lindsay Davenport finished as No. 1.
Story | Conversation | November 13, 2004 -
Sharapova showed champion's mindset
Pam ShriverMaria Sharapova came out strong against Serena Williams at the start.
Story | Conversation | July 03, 2004 -
Serena should win third title
Pam ShriverSerena Williams should win this final, but Maria Sharapova should make it interesting.
Story | Conversation | July 02, 2004 -
Serena, Mauresmo should advance
Pam ShriverSerena Williams has the edge against Jennifer Capriati on a grass court.
Story | Conversation | June 29, 2004 -
Sharapova's chance to break out
Pam ShriverDramatic storylines lead off the second week of play at Wimbledon.
Story | Conversation | June 27, 2004


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A brand new episode of Disney Channel's "K.C. Undercover" is airing tonight, January 25, 2015! The episode is titled "My Sister from Another Mother…Board," and it will air at 8:30pm ET/PT.
Here's a description of the episode:
K.C. tries to convince her parents that her brother, Ernie, who is a genius with computers but pretty clumsy at everything else, is ready to become a spy. However, Craig and Kira have a different plan and introduce them to their new little sister, Judy – a sophisticated humanoid robot disguised as a precocious 10-year-old.
Zendaya will be live Tweeting during the episode! She told fans:
I'll be live tweeting 4 East Coast & West Coast on Sunday…might even have a few cast members join me!! b sure 2 tune in!! #KCUndercover
Will you be watching?


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The AAFP said it supports the Accuracy in Medicare Physician Payment Act, which Board Chair Glen Stream, M.D., called a "long overdue" bill that could significantly change how Medicare pays physicians who provide quality, efficient health care. The bill, introduced by Rep. Jim McDermott, M.D., D-Wash., would supplement work of the Relative Value Scale Update Committee with an expert panel to oversee the valuation of physician services in Medicare and help correct distortions in the fee schedule.
View Full Article in:
AAFP News NowPublished in Brief:


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A collection of news and information related to Chicago Sky published by this site and its partners.
Top Chicago Sky Articles
Displaying items 12-22
Champ Bailey cut by New Orleans Saints
Sky secure 80-77 victory in playoff opener
Sky win more than making history
UConn, Sun Represented On USA Invite List
Story | Aug 25, 2014 | 10:02 AMFormer UConn All-Americans Bria Hartley, Stefanie Dolson, current Husky All-American Breanna Stewart and Connecticut Sun rookie Chiney Ogwumike are among the 27 players who will begin training in defense of the USA's FIBA World Championship title on... -
Many With Connecticut Ties In Women's National Team Pool
Fever hold on for 71-67 win over Sky
Sky continue playoff push, beat Mystics 72-69
Sky clinch postseason berth
USA Basketball Sets Complete Exhibition Schedule for Women's National Team
Story | Aug 7, 2014 | 8:55 AMGeno Auriemma's 2014 USA Basketball Women's National Team will play a Red-White intrasquad game Sept. 11 at 7 p.m., at the University of Delaware's Bob Carpenter Center. This will preceed the Sept. 15 exhibition contest versus Canada at the Webster Bank... -
For Rewards, Increasing Risks
Tragedy Has Come Close To Many WNBA Players Overseas
Story | Aug 10, 2014 | 8:08 AMThe WNBA players who do not participate in the playoffs or have USA Basketball obligations can head overseas almost immediately after the WNBA season ends in early October. There are six teams in the Israeli pro league. Last season, Renee Montgomery,...


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......Star pps reaching $3.00 or breaking the $1.00 barrier? If you ask me, Star will break $1 and not reach $3.00 unless there is reverse split to prevent delisting. JMHO Regrets Drum
And with all your "Infinite Wisdom" you still managed to LOSE over 400 THOUSAND on RMBS?!! LOL
Sentiment: Strong Buy


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Mar 29, 2012, 11:42 PM | ||
SteveT |
Latest blog entry: My hangar...
Mar 30, 2012, 02:03 AM | ||
...does the opposite for me... great little engine, purrs like a kitten. many times I was thinking that it wasn't any more assaulting in person than a big electric. OS did their thing properly with the included muffler for sure, quite awesome. |
Mar 30, 2012, 02:13 AM | |
Sounded great to me Arron...."almost" enough to make me want a gasser.......
Hmmmmm....let me think about this......... Nah....too many "cons" for me....no place to keep it, don't want to haul a gasser in my car, and a few other things too... SteveT |
Latest blog entry: My hangar...
Mar 30, 2012, 03:47 AM | |
Going back in the day....when gassers were pretty much your only option for large planes.....was a pain....lugging around so much kit...the hassles of fuel storage mixing...pumping...priming...starting...mess mess mess....then can't get engine to start going back home again....Grrrrr With the electric you just charge and go....and bar the odd electrical mishap - is so much the now way to go.... So why do I hanker to go through all that grief again - looking longingly at 50cc engines..... |
Mar 30, 2012, 08:18 AM | ||
Mar 30, 2012, 08:51 AM | |
The problem I've had with hinges is not necessarily the pins coming loose from the wood (although I have had this happen too), it's the actual pin inside the hinge wearing out the plastic and causing failure. Actually had the rudder on my 72 depart ship during a snap once. Landed the plane with the rudder flappin in the breeze held on by only the servo linkage. That was exciting!
When I noticed the elevator hinges getting loose I opted to replace them since I did NOT want the elevator jumping ship mid flight. It didn't seem physically possible to install new hinges without cutting up the tail of the plane a little. I just couldn't get the elevator back far enough to make enough space to insert new hinges. Wound up cutting through the bit of wood at the bottom of the hole that the elevator joiner goes through, which allowed the elevator to fall into the lightening hole below it. This gave me the room I needed to work. I think I have a picture of this somewhere. I'll see if I can find it... Found it: And just for fun, here is a photo from when the rudder came off. |
Mar 30, 2012, 09:31 AM | |
I made some new gear for mine out of aluminum stock. It's a temporary fix but was really easy and doesn't even look that bad. It cost me less than $5 and took about 20 minutes + painting. I got the idea from a post on the 51 slick thread a few days ago. All you need is some 3/4 x 1/8 aluminum bar stock. You can find it at Home Depot for sure. Then I just held up the CF gear to it and marked the bend points. Used my little vice to bend it. Drilled some holes, knocked off the burrs with my dremel and painted it black. Good for plenty of landings till the new gear comes back in stock
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Darthula Fulcher is my gggrandmother. She married John Coleman Blaydes Fulcher, (3rd cousins) and they moved to Nashville after the war. EA Fulcher was at least a Capt with the 10th Vir Calvary. After the war he went into the whiskey business making Fulcher's Old Vir Mountain Whiskey. A few years ago I bought a back bar bottle which was hand lettered in white enamel "Fulcher's Old Vir Mountain Whiskey". My brother bought some paper labels that went on the regular bottles, and they had Edwins signature on them. Their father, William, is buried here in Nashville. My brother has the old family bible, but it's in bad shape. We have a cousin who's really into the family stuff (as if I'm not), who lives in Richmond, and she has access to a lot of info. Feel free to contact me direct as we would love to get pictures, etc. and share our info, but not the bottle! lol Notify Administrator about this message?
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Get your GMail offline1 comment One of the most popular services that Google has launched is without a doubt Gmail. The mailclient is being used by more and more users worldwide. Partly because of th...... read more
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Vkontakte goes contextual with A...1 comment One of the biggest social networks in Russia, Vkontakte.ru is planning on implementing a contextual ad network this summer.
The network will be a mash up between Goog...... read more
A bloggers view on search in Eur...2 comments [Editor]Last week we announced Dennis Sievers as one of the new bloggers at Searchcowboys. Dennis is a loyal Searchcowboysfan and is an SEO specialist from the Netherl...... read more
Yahoo being sued in Belgium1 comment Yahoo! is being sued in Belgium for not cooperating with the Belgian Justice Department. Today (Monday) the case will be handled in Dendermonde, Belgium.
The District...... read more
Microsoft fires Fast Search CEO ...1 comment A lot of things are happening in Norway these days. Last week Ask.com used Google to promote pirate websites, the week before it was Google itself who decided to leave...... read more
Watch YouTube in your Gtalk0 comments A pretty nice feature was rolled by Google last week: YouTube in GTalk. When you use GTalk from out of your Gmail and post a YouTube link to the person you're talking to both you and your chat-partner can watch the video within your chat.
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Calling Europe: Holland in Janua...2 comments Today we are proud to present the very first episode of "Calling Europe", a podcast in which we call search marketers from around Europe to find out what h...... read more
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5000 have to go at Microsoft1 comment The times are hardening. After the cutbacks at Yahoo and the elimination of contractors at Google now the third major player announces it has to do some heavy cutbacks...... read more
Ask uses Google to promote pirat...1 comment Apparently Norwegian companies, some of which in the record-business, saw their Adwords text adds appear on Isohunt, a Bit Torrent search engine. This news was shared ...... read more
Are you a Searchcowboy?0 comments As you may have noticed Searchcowboys got off to a rocking start. Since our 'official launch' only two weeks ago we saw an immense growth in visitors, posts and writers.
Off course we were very happy to introduce some new writers to you.
All writers with great knowledge of what's going on in search and in
Europe in particular.
Since the launch we received several e-mails from highly respected
search market from around Europe. You will see contributions from them
in the coming day...... read more
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Google kills two more products0 comments Google is cutting back heavily on its products and services. With the closing down of uploads to Google Video, Catalog Search, Notebook, Dodgeball, Jaiku and Mashup Ed...... read more
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pet June 5, 2011
tara patrick yan!
judas May 23, 2011
namit talaba ba!
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ramon January 10, 2011
that's TERA PATRICK, not patricia javier
romar November 10, 2010
pakU October 9, 2010
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wala lang!!!! January 15, 2011
sarap nang pipi in patricia parang strawberry pula pa!!!!!!!!!
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Ako free love
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vincedel August 2, 2010
rose,22o bayan ang snabe mo,tingnan natin,,,,
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hi rafael!ano number mo?
trer July 6, 2010
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parang hindi naman yan
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boy tigasin August 7, 2010
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text:
Total Time:
Prep Time:
Cook Time:
55 mins
20 mins
35 mins
Zurie's Note:
It's easy and tasty! It's slightly different from the usual shrimp recipes. I felt like a light cheesy sauce, and this is what developed. Prep time does not include time perhaps needed for cleaning shrimps.
My Private Note
Units: US | Metric
- 2 lbs large shrimp, headless (1 kg)
- 1 medium onion
- 1 green bell pepper
- 1 yellow bell pepper
- 1 teaspoon chili pepper flakes, dried, hot
- 1 tablespoon fish sauce
- 1 tablespoon oyster sauce
- 1 tablespoon lime juice or 1 tablespoon lemon juice
- 1/2 teaspoon salt
- oil (for frying)
- 1 tablespoon flour
- 1 cup milk (250 ml)
- 2 cups mild cheese, grated (I used Tilsiter and a young, mild Pecorino)
- 1/2 teaspoon nutmeg
- 1 teaspoon finely chopped garlic
- 1/2 teaspoon salt
- 1Start with the shrimps: depending on how you bought them, they might need picking over or peeling. Try to keep tails on. Rinse well.
- 2Remove seeds and ribs from bell peppers and cut flesh into bite-sized pieces. Peel and chop the onion. (Use any colour bell peppers you have).
- 3Use a wok over a high flame: it's easiest. Fry the onions and peppers in oil, stirring often, until they are soft and "reduced" and threatening to burn - about 20 minutes. During the frying, sprinkle in the dried hot pepper flakes.
- 4The wok should be quite hot at this stage, so add all the cleaned shrimps in one go. You might have to add more oil.
- 5Stir, moving the shrimps around, until they have all become pinky white and curled up.
- 6(If you feel the wok would be too crowded, remove the pepper-onion mixture to a bowl, add a little more oil, heat well, and then cook the shrimps on their own).
- 7Don't overcook the shrimps. While they're cooking, add the fish and oyster sauce, and the lime or lemon juice.
- 8When shrimps are cooked, take wok off heat. If you removed the pepper-onion mixture, stir back into shrimps.
- 9In another medium pot, whisk the flour into the milk, put over a high heat, and keep whisking until milk boils and thickens a little.
- 10Remove from heat, and stir in the cheese until it melts and the sauce is smooth. (Cheese do not like being boiled). Stir in the nutmeg, garlic and salt.
- 11Add this cheese sauce to the shrimp mixture and fold in well.
- 12Remove to an oven dish, cover, and keep warm until needed. You could garnish it with snipped spring onions or chives.
- 13Nice served with brown basmati rice. I also cooked chopped green beans to which I added 1 wheel, crumbled, of feta cheese.
- 14*The cheese: I used two mild cheeses; felt as if cheddar would be too strong. Use whatever you have, or cheese bits you need to use up.
Browse Our Top < 60 Mins Recipes
Nutritional Facts for Shrimps With Bell Peppers and Cheese Sauce
Serving Size: 1 (409 g)
Servings Per Recipe: 4
- Amount Per Serving
- % Daily Value
- Calories 325.2
- Calories from Fat 58
- 17%
- Total Fat 6.4 g
- 9%
- Saturated Fat 2.2 g
- 11%
- Cholesterol 354.1 mg
- 118%
- Sodium 1421.2 mg
- 59%
- Total Carbohydrate 14.9 g
- 4%
- Dietary Fiber 1.5 g
- 6%
- Sugars 2.2 g
- 9%
- Protein 49.7 g
- 99%
The following items or measurements are not included:
mild cheese
Ideas from Food.com


text:
Break the Limits!
You are trapped in a room and the only thing you can do is think.
4.16 / 5.00 37,747 ViewsCap'n Marcela
Can you help Cap'n Marcela save her village from Evil Puffy shirt Morgan?
3.93 / 5.00 6,135 ViewsWhoohoo! Frontpage, thanks! Thanks also for all your comments.
Hi All! Well this is the first new game from us for a while but I hope you'll agree it's a really nice one, i look forward to hearing your comments.
Anyway... Ray's got a death-wish and he's dancing on the front of your car. Will your driving skills keep him safe? This crazy driving game has you as the stunt driver on the shoot of a music video. Featuring some great animation (check out the death scene!), rocking soundtrack and really cool cut-scenes.
Use the mouse to move the car and hold down the left mouse button to speed up and score more points.
Whenever Ray falls off just flick the car to spring him back up.
Over all good game
too short but for the time you get to play its super fun


text:
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What your tongue says about your health
In 2003, Seau was traded to the Miami Dolphins for a conditional draft choice. He started 15 games that year, but was limited in 2004 by a torn pectoral muscle.
As new details about his death are released, look back at the 20-year career of the late NFL great Junior Seau.


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Posted 10/04/2012
I hope so!! I can't wait to see Stella :)
Nicole (30) Boys Circ'd, Girls Ears Pierced, Piggies Painted and Huggie Wearin, All Csection, Formula Fed and Vax'd!! And All are Overflowing with AWESOMENESS!!
Posted 10/04/2012
Yeah, she is pretty magical :) Love the bows!!! @ Berk, love cats! Have 4 cunty cats here!
Posted 10/04/2012
Simply said...I LOVE this thread. Its like we all get eachother!! When I talk random, you know, that no filter, what pops in your head talk, my husband cant keep up. :)
Caiden William 5-20-08
Kellen Edward 11-16-10...born with Prader Willi Syndrome
Chloe Marie 4-13-12
Posted 10/04/2012
And I totally just rhymed in my first line. :p Go me!
Caiden William 5-20-08
Kellen Edward 11-16-10...born with Prader Willi Syndrome
Chloe Marie 4-13-12
Last edited 10/04/2012
Nicole I want a bow to put on Jackson! As long as its auburn colors for DF and football related, it cant be too weird could it?! ;) my sweet baby has a double ear infection and hes just pitiful today :( I feel so bad for him. I just want to make it go away.
-Had our first baby boy on 4-11-12
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