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You're leaving Wedding Paper Divas to see the Deal of the Day at our parent site, Tiny Prints.
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"I am having a summer wedding in a garden, and these invites perfectly captured our wedding. They are simple, sturdy, and elegant. The design process was a breeze and we received our invites in days. I can't wait to send them out!"
"I was skeptical about ordering invitations online but had only heard wonderful things about Wedding Paper Divas, so we decided to go ahead and order. I am so glad that we did! The invitations turned out beautifully. The paper is incredibly nice, the design is flawless, and the color is just like what is shown on the site. We decided not to personalize the color as the color was very similar to our wedding colors. However, we did have an extra line we wanted added and our designer helped us with that tremendously! I also contacted Wedding Paper Divas with a few questions here and there, and they were always quick to answer and very helpful. Thank you for making our invitations so beautiful!"
"out of all of the samples we ordered, the one really stood out! the texture and quality of the paper is amazing, and the design is elegant enough but yet still casual, perfect for our outdoor wedding! we were able to completely customize the colors as well, so they match our colors exactly. We did meadow green blooms with navy accents and grey font. they are stunning in person!"
"We got the save-the-dates earlier along the same theme, and were pumped we found these invites to match. They look great, & they fit perfectly with our vintage-winery theme. Everything arrived early, packaged together, everything is organized, pulled together... exactly what I need right now in the wedding planning process!"
"I just ordered my wedding invitations with enclosure cards and I am in love with them! The personalizing process was a breeze. I was a little bit skeptical on how you have to buy the invites before you can see the designers changes that you want done, but it was well worth it! The designers changed everything I asked and level made some etiquette touch-ups that I didn't catch myself in my wording. They look fantastic and go with our overall theme wonderfully. Thank you WPD!!"


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Pros and Cons of manual conversion
After converting automatic to manual transmission, MVS user Japedo shares some first impressions:
-Increased fuel economy
-Drives faster from 0 to 120 km/hr
-Lots of fun to drive!
-The shifter nearly hits the cups in the cup holders when in 2nd, 3rd, or reverse.
-Harder to eat, drink, or text while driving (not that he does this)
-No more cruise control
- The wife has to learn how to drive stick now
Manual conversion first impressions


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I ordered this hat expecting what it is advertised as; black hat, silver ribbon 65% 35% mixed fabric, Faddism label. I received a black on black hat, made in China, 100% cotton. I actually returned this item so that I could receive the correct item. I was sent the same wrong hat so I returned the second one as well. I did not receive an invoice in either of the two orders either as I normally do when I receive items from Overstock. I requested a full refund and am awaiting this. Overstock needs to rewrite the description of this item.
- How did the color on site compare with the actual product? Did not. It is advertised as a black hat with silver ribbon; it was shipped as black hat, black ribbon
- Please tell us about the quality of the product. The advertised hat was 65% and 35% mixed fabric. I received a 100% cotton hat made in China. Not a Faddism hat. No label/no invoice
- How accurate was the sizing? correct
The hat is very VERY low quality. I am mainly aggravated with overstock because we paid for a 2 day shipping and we didn't get the hat until 7 days later. So we are very mad and will never shop at overstock.


text: YEAR MY PARENTS WENT ON VACATION TFF 2007 Narrative Feature Release Year: 2006 Runtime: 104 minutes Directed By: Cao Hamburger Country: Brazil It's the summer of 1970, and twelve-year-old Mauro's biggest concern is whether Brazil wins the World Cup-until his politicized parents are forced to flee the country, and he is thrust into the alien world of Sao Paolo's Jewish community. This sensitive drama shows an innocent caught up in a ferociously repressive dictatorship he knows nothing about. | Read More


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Many of us understand that we have moved beyond Web 2.0 and into Web 3.0 – sometimes called the Semantic Web. What does this mean for the future librarians? Here are 8 easy steps to becoming Semantic Web savvy.
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Linda M's curator insight,
June 9, 2014 8:42 PM
Another example of the importance of collaboration in today's digital age.
Ruth Snape's curator insight,
January 14, 2014 11:07 AM
An inside look at Rikkyo University's library in Tokyo, showing how when university libraries offer comfortable learning spaces for group discussions, and long opening hours, students visit the library more often for longer. |
Fliss Clooney's curator insight,
January 20, 2014 5:22 AM
Comprehensive listing of sources of free ebooks
Linda M's curator insight,
June 9, 2014 8:59 PM
21st Century libraries are more than just collections. We need to be about 'connections' as well in order to stay relevant and to meet our clients needs. |


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My husband and I moved to Norwood a few years ago and
have enjoyed learning about the town and community. One local feature that was a nice surprise
for me is Norwood Airport. I grew up
near a small airport and my family has long been interested in aviation and
airplanes. For me the noise of planes
flying overhead brings back memories of being out in the backyard during the
summer and looking up to see what kind of plane was overhead; one summer there
were some gliders which was exciting.
Many of today's municipal airports were sites of major
events in aviation history and served as training fields during World War I and
World War II. "Norwood: a history" by
Patricia Fanning provides some history on the Norwood Airport. In 1942 a small airfield was approved by the
town as the site of the Norwood Airport.
The new airport was used for military training until the end of World
War II. After the war, local aviation
company Wiggins Airlines moved their aircraft sales and repairs, and flight
lessons from Canton to Norwood and expanded their business to include passenger
and cargo operations (150-151). This
past fall the Wings of Freedom tour of historic World War II made its annual
stop here on Norwood Day. College Park
Airport in Maryland is considered to be the nation's longest continuously
operating airport and was the site of the Wrights' early military
demonstrations. Today it has a small
museum and is used for general aviation.
Pearson Airfield in Vancouver, WA is part of Fort Vancouver National
Historic Site and was the landing site of the first transpolar flight from
Moscow in 1937. My childhood airport was
near several early airplane manufacturers.
Alastair Gordon's "Naked airport: a cultural history of the world's most
revolutionary structure "examines the history of airports.


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Riad Farnatchi
Many medina properties are expanding, including Riad Farnatchi, which was opened in 2004 by British hotelier Jonathan Wix (who launched the Scotsman, in Edinburgh, and Paris's Hôtel de la Trémoille). Its five guest rooms—with large fireplaces, sunken bathtubs, and Modernist furniture—were so popular that Wix acquired an adjacent mansion and incorporated four more chic suites set around a maze of courtyards, terraces, and bhous (alcove seating areas).
Tune in on Wednesdays at 10PM ET for Top Chef: Boston, the 12th season of Bravo's Emmy-Award winning, hit reality series.


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News articles related to our company and products.
December 15, 2008 Source Kiwi
Dear Amy,
I tried the new Tamale Verde last night, and it was awesome! Thanks so much for another great tasting quick meal.
From Vanessa Lewis
Dear Amy,
Wow! I have just recently started buying your frozen dinners and am SO thankful for the wonderful vegetarian selection. I am an ovo-lacto
vegetarian and have craved "chicken" potpies for the past 8 years. I finally got my wish when I bought your vegetarian pot pies a few days ago. And now I'm hooked. Absolutely delicious! Kudos to you for your
excellent recipes!
From Emily Fry


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Cue "O Fortuna," because this mansion is epic. It's three hours outside DC, but with nearly 30,000 square feet of living space, it could make a sweet weekend getaway for you and your two dozen closest friends. The main house—the one that looks like a Disney attraction—boasts 15,696 square feet and 11 bedrooms and bathrooms. Add in the four guest homes on the 273-acre property and you get a total of 25 bedrooms and 21 baths.
The estate dates back to 1848 and comes with lots of historic touches, including ornate crown molding, built-in bookcases, and nine fireplaces. You also get your own conference center with a "community kitchen," an indoor racquetball court, a tennis court, and a swimming pool. The grounds are filled with manicured hedges, neoclassical-style sculptures, and stone pathways leading to the guest cottages.
The house is on the market for $5.49 million. Take a peek at the pictures below, then head to the Rob and Brent Group of TTR Sotheby International for complete details.
For more real-estate picks, follow Open House on Twitter at @openhouse.
It's 15 miles from the White House, but you can play POTUS at home in the wood-paneled library/office of this decked out McLean mansion. Whether the flags flanking the desk convey is unclear, but they're probably worth negotiating for since they add to the room's House of Cards vibe.
What else can you find tucked away among the home's cozy 14,200 square feet? Lots of chandeliers—they seem to be everywhere, including in the six bedrooms. There are also ten bathrooms with some of the most ornate vanities you've ever seen. It would be a crime not to wipe up the drips after washing your hands in those things, and given that there are nine security cameras on the property, it wouldn't hurt to be on your best behavior.
The French Provincial style spread comes with a wine room, a gym, a movie theater, a sauna, a five-car garage, and plenty of privacy since it's surrounded by forest and secured behind an iron gate.
This home is on the market for $4.9 million. Take a peek at the pictures below, then head to Washington Fine Properties for complete details.
For more real-estate picks, follow Open House on Twitter at @openhouse.
Chateaus in Virginia, award-winning townhouses in Georgetown, and record-breaking penthouses in Bethesda—take a stroll down memory lane with a look at the year's most opulent listings.
10. At $3.9 million, this home was the most expensive ever sold in Logan Circle.
9. This $6.5-million historic schoolhouse near H Street came with nine rentable lofts in addition to a two-story owner's penthouse.
8. For $7.95 million, you can call this still-on-the-market Ritz Carlton penthouse home.
7. For buyers with traditional taste and $8.1 million to spare, this Georgian-style mansion on Embassy Row was just the ticket.
6. This $8.75-million estate in Potomac sits on 52 acres—yes, 52.
5. This Potomac Colonial's $9.75-million price tag included 16 bathrooms.
4. If it goes for the list price of $10.5 million, this Bethesda penthouse will become the most expensive condo ever sold in Washington.
3. Contemporary interiors made this $10.5-million award-winning Georgetown townhouse a standout.
2. Built in 1797, this $11-million Federal-style home in Georgetown came with plenty of history.
1. And finally, our most opulent listing of the year: a nearly $13-million chateau in McLean, in which it's impossible to imagine anyone ever feeling okay about wearing sweatpants.
This four-story mansion in Clifton, Virginia, originally listed for $9.8 million, boasts seven bedrooms, nine bathrooms, and an eight-car garage (because seven would be gauche). You probably won't even need to use the gym, since moving between the sitting room, spacious living room, and two kitchens will likely burn enough calories. The chateau also includes a formal dining room, a library, an elevator, and a sauna, natch. Not convinced yet? There are also five fireplaces, an indoor pool, and a three-story-high foyer with a chandelier that could pose a serious dusting challenge.
Take a look at the pictures below, then head to Jobin Realty for complete details.
For more real-estate picks, follow Open House on Twitter at @openhouse.
Sold: $5,000,000.
Listed: $5,500,000.
Days on market: 42.
Where: Georgetown.
Style: Colonial.
Bragging points: Seven bedrooms, six baths, large yard, eat-in kitchen.
Who: Bought by Michael Rankin, managing partner of TTR Sotheby's International Realty.
Sold: $6,833,333.
Listed: $7,495,000.
Days on market: 484.
Where: Wesley Heights.
Style: Colonial.
Bragging points: Seven bedrooms, 12 baths (including two in the master suite), four-car garage, swimming pool; on 1.4 acres.
Who: Bought by Mae Haney Grennan, chief counsel for the Franklin L. Haney Company, a real-estate investment firm.
Sold: $2,743,000.
Listed: $2,743,000.
Days on market: 1.
Where: Wesley Heights.
Style: Tudor.
Bragging points:Six bedrooms, seven baths; newly built custom home.
Who: Bought by Stephen and Randi Orava. Stephen is a partner at King & Spalding, where he chairs the international-trade practice.
Sold: $2,500,000.
Listed: $2,745,000.
Days on market: 886.
Where: Potomac.
Style: Colonial.
Bragging points:Five bedrooms, nine baths, outdoor kitchen, gated entrance; on two acres.
Who: Sold by retired NBA point guard Sherman Douglas, who played for Miami, Boston, Milwaukee, New Jersey, and the LA Clippers.
Sold: $2,580,000.
Listed: $2,950,000.
Days on market: 642.
Where: Potomac.
Style: Colonial.
Bragging points: Four bedrooms, six baths, with an interior by acclaimed designer Barry Dixon. Featured in House Beautiful and Decor magazines.
Who: Sold by a trustee of Patrick McGeehin, a senior managing director at FTI Consulting.
Sold: $2,700,000.
Listed: $3,250,000.
Days on market: 113.
Where: McLean.
Style: Colonial.
Bragging points: Five bedrooms,seven baths,library, wine storage, billiard room.
Who: Bought by Mehdi Tehranchi, chairman and CEO of Notable Solutions, an information-technology company.
Sold: $2,259,000.
Listed: $2,299,900.
Days on market: 68.
Where: McLean.
Style: Colonial.
Bragging points: Six bedrooms, seven baths, sunroom, walk-out basement, two-story foyer, pool.
Who: Sold by neurologist Sheila Jahan.
Some sales information provided by American City Business Leads and Diana Hart of TTR Sotheby International Realty. Sales listed were the most expensive of those with publicly available details.
This article appears in the December 2014 issue of Washingtonian.
This Spring Valley home, designed by award-winning local architect Robert Gurney, is a rare contemporary find among the neighborhood's more traditional styles. Outside, Gurney's use of rustic stone and clean lines lend a timeless appeal that keeps the house from veering too far from the area's classic aesthetic—but inside, it's a modern marvel. You'll find floor-to-ceiling windows, warm woods contrasted with metal and glass, and plenty of skylights. The home boasts six bedrooms and six baths, plus an indoor pool for year-round use. Other features include five fireplaces, tiered decks, and lots of outdoor entertaining space.
Take a look at the pictures below, then head to Sotheby's Realty for complete details.
For more real-estate picks, follow Open House on Twitter at @openhouse.
The DC Design House—an annual tradition that benefits Children's National Health System—doesn't open until spring, but we got an early look inside the under-construction custom home where this year's event will be held. This is the first time in the fundraiser's eight-year history that the Design House is located in Virginia, and only the second time that it's been in brand new construction.
The home is part of Mackall Farms, a 12-property development in McLean from Artisan Builders. True to the community's name, the house incorporates rustic, farmhouse-style features that Artisan principal Stephen Yeonas says are meant to make it look "like it's been there a while, like it didn't just pop up as a McMansion in the middle of nowhere."
The Design House has five bedrooms, five full bathrooms, and three half baths, spread over 9,000 square feet. Its various spaces, including hallways and foyers, will be divided among more than 20 interior designers to decorate. The public can tour the results from April 11 to May 10. After that, the home will hit the market for $4.5 million.
Here's a sneak peek inside.
You'll find this stone Colonial on 30th Street, Northwest, not far from the Naval Observatory and the Vice President's residence. The house boasts large, sunny living spaces, five bedrooms, an elegant formal dining room, and a spacious kitchen. Need a bathroom? There are eight to choose from, including two in the master suite. A finished basement, currently used as a contemporary home office, could also function as an au pair suite. The real draw, though, is the home's backyard, which features a waterfall and a pool.
Take a look at the pictures below, then head to Sotheby's Realty for complete details.
For more real-estate picks, follow Open House on Twitter at @openhouse.
This eight-year-old property boasts five bedrooms, eight bathrooms, two kitchens, six fireplaces, a gym, media room, and a library spread over three floors. Outside, you'll find an expansive entertaining space, a swimming pool, and yet another kitchen, all overlooking rolling hills and a pond. And if all that luxury just gets to be too much, the owners can retreat to a master suite that includes a sitting area, wet bar, and a huge bathroom with a soaking tub and its own TV.
Take a peek at the photos below, then head to Washington Fine Properties for complete details.
For more real-estate picks, follow Open House on Twitter at @openhouse.
Logan Circle saw its highest residential sale in history on Monday when an 11-bed, seven-bath rowhouse sold for $3.9 million, as reported by the Washington Post. Built in 1885, the Victorian mansion was originally listed at $4.445 million. The 9,880-square-foot home, filled with exposed brick, original molding, eight fireplaces, an in-law suite with its own kitchen, and a spacious patio out back, sold in two months.
Take a peek inside 1332 Vermont Ave., NW below, then head to TTR Sotheby's for all the details.
For more real-estate picks, follow Open House on Twitter at @openhouse.


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The Window Cleaner
A short muisc video based on the classic song "The Window Cleaner" sung by George Formby
4.39 / 5.00 6,121 ViewsThank you so much for the Front Page, Daily Feature, Weekly 3rd and my very first Review Crew Pick!
Check my site for updates on the 6 brand new episodes... www.kenmcintyre.com
this was pretty funny :D
hahaha ^_^ making jokes of retarded people is evil.
*roflrofl* but very funny
quite good
the best bit (& only funny bit) was when that evil fool says "because i'm going to kill you, & your going to die!!!! *evil laugh*". not that funny, i think it was meant to be funny to americans, i didn't find it that funny as im british.
was 'okay'
Since the movie was supposed to be funny, which to me it wasn't funny at all... I'll rate this a 5/10. I watched this with a straight face the entire time.
Btw- I thought the end was too predictable with the big explosion and having the retard win.
Go Super Retarded Dog!!!
This clip was fucking hilarious. You did a good job with the voice overs. Even though I don't like Acoustic, the song was also funny. I hope to see another episode of Super Retarded Dog.
That was funny...
This is definetly an instant classic. Going straight to my favorites list. Thanks for making this you did a great job!


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Think Asia. Think DKSH.
We help companies to grow their business in new and existing markets
Market Expansion Services along your company's value chain
We provide access to a global sourcing network
Our unique sourcing network across more than 70 markets and a deep industry expertise enable us to provide any specialty chemicals and ingredients you need, while offering the perfect mix of cost-effectiveness, quality, and dependable supply. At the same time, we ensure compliance with safety and environmental regulations. With DKSH, you can expand your sourcing base and focus on growing your business.
We enable you to innovate for growth
In our application, formulation, and product development laboratories, we generate new product ideas, develop, and customize them. We work on new ingredients and technology applications, provide hands-on training, and run acceptance tests. We take the information gathered from our market activity, combine it with our expertise to conduct feasibility studies, and turn our market insight into strategic advice for our business partners.
We open up new revenue opportunities for you
We offer a complete array of marketing and sales services for consumer goods, luxury and lifestyle products, healthcare products, performance materials, and technology products. We have a long-standing track record in brand-building and service all relevant channels, customers, and outlets. In Asia Pacific, we offer comprehensive market coverage in Australia, China, Japan, Hong Kong, Korea, Laos, Malaysia, Myanmar, Singapore, Taiwan, Thailand, and Vietnam.
We deliver what you need, when you need it, where you need it
With our unmatched logistics infrastructure and its distribution centers, we can transport, store, and distribute your products efficiently and professionally. As part of our comprehensive package of Market Expansion Services, you can outsource many additional specialized services with us, including product registration, regulatory support, customs handling, importation, logistics, repackaging, invoicing, cash collection, and supply chain management.
We are at your service throughout the entire lifespan of your products
We offer a broad range of after-sales services and support, which ensure top quality standards, fast problem resolution, and the ability to establish a high-value image. Our expertly trained teams provide customer service, repairs and maintenance, on-the-spot training, and know-how transfer, offering real added value to suppliers and customers alike.
Feature of the month
DKSH opens a new healthcare distribution center in Myanmar
DKSH is strengthening its presence in Myanmar by opening a technologically-advanced 2,200 square meter (24,000 square feet) healthcare distribution center with capacity for further expansion to 5,000 square meters.
Strategically located for fast inbound and outbound transportation with easy access, the distribution center plays a vital role in addressing Myanmar's fast-growing demand for pharmaceuticals, consumer health and medical device products as well as for personal care and nutritionals.
DKSH's modern fleet will use the distribution center as a hub to serve more than 28,300 hospitals, clinics, pharmacies and retail outlets nationwide. The new facility strengthens DKSH's unique capillary distribution network in Myanmar, which guarantees customers in-time access to healthcare products even in the most remote parts of the country.
Which Business Unit can serve your needs?
Consumer GoodsDKSH's Business Unit Consumer Goods is Asia's leading Market Expansion Services provider with focus on fast moving consumer goods, food services and luxury goods.
Luxury & LifestyleLuxury & Lifestyle is a Business Segment of DKSH's Business Unit Consumer Goods, which provides Market Expansion Services for Western high-end and lifestyle watches, accessories and apparel, and household luxury goods across Asia.
HealthcareDKSH's Business Unit Healthcare is the leading partner for healthcare companies seeking to grow their business in Asia, offering a wide range of Market Expansion Services from product registration, marketing and sales to physical distribution.
Performance MaterialsDKSH´s Business Unit Performance Materials is a leading global provider of Market Expansion Services that sources, develops, markets, and distributes a wide range of specialty chemicals and ingredients.
TechnologyDKSH Business Unit Technology provides Market Expansion Services around a broad range of technology products, services and applications. In Malaysia we focus on integrated solutions, applications, and service support.
28/11/2014DKSH awarded top 3 ranking as "Best new listed company 2014" at European Small and Mid-Cap Awards
28/11/2014DKSH and Fermenta Biotech sign exclusive distribution agreement for nine Asian countries
03/11/2014DKSH starts strategic partnership with BASF in Asia
16/10/2014DKSH and Aspen expand reach in Malaysia
15/10/2014DKSH extends relationship with Roche across Asia


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Reporting third quarter revenue at $57.1 million, an 11.5% increase year-over-year, Higher One Holdings Inc. ( ONE ) provides financial services and data analytics to more than 1,600 college and university campuses in the U.S. Achieving more than 340% revenue growth over five years, the company recently received recognition, ranking 259th on Deloitte's Technology Fast 500 , a list of the 500 fastest growing technology, media, telecommunications, life sciences and clean technology companies in North America. The Fast 500 winners were chosen based on percentage fiscal year revenue growth from 2008 to 2012. Higher One's CEO Mark Volchek commented in a company press release: "Higher One is pleased to be regarded by Deloitte for the fourth year in a row. We have grown by truly focusing on the higher education market-helping colleges and universities allocate resources more efficiently to provide a higher quality of service and education to college students. With this direction, we are on a shared course for success with our customers." Five gurus traded ONE in the third quarter of 2013, and according to GuruFocus Real Time Picks , Glenn Greenberg of Brave Warrior Capital just made a reduction to his ONE stake. Higher One Holdings Inc. ( ONE ) Up 12% over 12 months, Higher One Holdings Inc. has a market cap of $465.5 million; its shares were traded at around $9.90 with a P/E ratio of 26.00. The company does not pay a dividend. Higher One Holdings Inc. reported financial results for the third quarter 2013 with revenue of $57.1 million, up from the same quarter of 2012, at $51.2 million. Due to a proposed settlement on class action lawsuits against the company, Higher One Holdings reported a net loss of ($5.5) million (GAAP) for the quarter. In the third quarter of 2012, the company's net income was $7.3 million (GAAP). Earnings in the reporting quarter were ($0.11) per GAAP diluted loss per share, compared to $0.13 in the same quarter of 2012. In the third quarter of 2013, the company's Campus Solutions modules total approximately 13 million. Up 5% from the same quarter last year, the number of OneAccounts at the end of the third quarter of 2013 was around 2.2 million, according to a company press release. Here's the GuruFocus analysis of ONE, showing two warnings. Tracking historical share price, revenue and net income: [ Enlarge Image ] Real Time Trade Guru Action: As of Nov. 27, 2013, Glenn Greenberg of Brave Warrior Capital reduced his position by 41.74%, selling shares in the average price range of $9.81. This latest reduction impacts his portfolio by -0.85%. Greenberg's current shares are 2,701,027 or 5.75% of shares outstanding. His holding history over seven quarters: [ Enlarge Image ] Third Quarter Guru Action As of Sept. 30, 2013, Paul Tudor Jones made a new buy of 13,400 shares at an average price of $9.15 per share, for a gain of 8.2%, his only gain in the trading history. In the first quarter of 2013, he sold out 27,300 shares at an average price of $10.17 per share, losing 2.7%. Jones has held ONE for 11 losing quarters out of 12. The holding's lowest point was a loss of 46.5% in the fourth quarter of 2010. In that quarter, he sold 75,000 shares at an average price of $18.49 per share. Also in the third quarter, Jeremy Grantham made a new buy of 13,300 shares at an average price of $9.15 per share, for a gain of 8.2%, his only gain in five quarters. In the second quarter of 2013, he sold out 44,700 shares at an average price of $10.22 per share, losing 3.1%. In four losing quarters out of five total, Grantham's new buy was the lowest point in the trading history. In the second quarter of 2012, he made a new buy of 20,400 shares at an average price of $13.79 per share, for a loss of 28.2%. Here's more third quarter action and insider selling of ONE. Check out the complete portfolio of Glenn Greenberg. Use the GuruFocus Value Screen to find 52-Week Lows and discover potentially deep value stocks held by billionaire Guru investors. GuruFocus Real Time Picks reports the stock purchases and sales that Gurus have made within the prior 2 weeks. The report time lag can be as short as 2 days after the date of the transaction. This feature is for Premium Members only. If you are not a Premium Member, we invite you for a 7-day Free Trial . About GuruFocus: GuruFocus.com tracks the stocks picks and portfolio holdings of the world's best investors. This value investing site offers stock screeners and valuation tools. And publishes daily articles tracking the latest moves of the world's best investors. GuruFocus also provides promising stock ideas in 3 monthly newsletters sent to Premium Members .
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From Seoul city council to the Korean Communication Commission, Uber faces serious legal trouble in South Korea.
The group that claims to have hacked Sony Pictures and has been publishing the information on the Internet says studio's employees have a chance to keep personal data private. It says more releases are coming.
Aimed at people in West Africa, the BBC will use the popular messaging app to provide updates about the spread of Ebola.
Although the West African nations stricken by the Ebola outbreak are not tech-savvy, text messaging, phone calls, and even radio are helping educate the most at-risk people.
The Data Cuisine project uses custom recipes to express data sets, often resulting in colorful culinary statements of information.
A pretty great grab-and-go camera bag, the Timbuk2 Informant camera sling is a perfect fit for dSLR or mirrorless camera users who want a lot of storage in a little bag.
Compact and fast, the Transcend ESD200 is an excellent storage and backup extension for your USB 3.0-enabled laptop.
The company has announced veteran security executive Alex Stamos as its CISO, confirming a rumor that he would be tapped for the role.
The current CIO of security firm Artemis and co-founder of the rebellious counter-conference TrustyCon will be Yahoo's first CISO in more than a year.
Dr. Glenn Singleman and his team of pilots will fly over the Grand Canyon in April, but not in the way you might expect -- they plan to make the world's first wingsuit crossing.


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1920s Jazz Age Costume Ideas
Street Style With a Downton Abbey Twist
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Street Style With a Downton Abbey Twist
Street style is a pretty recent phenomenon, but . . . what if it wasn't? The eight annual Jazz Age Lawn Party went on this past weekend on New York's Governors Island, and the stylish crowd came decked out in vintage-esque dresses and accessories straight from the '20s, with hair and makeup techniques to match the roaring times. See the ladies we loved (and some gents!), and let it inspire your next formal look.
Read More Street Style
Street Style
Link Love
- Say goodbye to the affordable Kate Spade shop — The Cut
- And the next face of Chanel is . . . — Style.com
- Joe Zee is the king of fashion, but it's not all fun and games — HuffPost Style
- Now you can get your hands on Shay Mitchell's jewelry — SheFinds
- Currently coveting: all of Victoria Beckham's must haves — Who What Wear
- You have to see Sarah Jessica Parker's latest shoe collection — InStyle
- Is there any hope for Coach? — Fashionista
- Dov Charney just can't let American Apparel go — Racked
- Put down the basic blazer — your work wardrobe, revamped — Lucky
Latest Fashion


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Here's how to buy into the 'Amazon of India'
A former IRS agent gives you inside tips
Join the NASDAQ Community today and get free, instant access to portfolios, stock ratings, real-time alerts, and more!
Shares of Atlantic Power ( AT ) are up 12% after releasing a better than expected earnings report for Q1 2013. Earnings were released after the close on Wednesday.
AT - which owns and operates a diverse fleet of power generation assets in the United States and Canada - reported Q1 2013 earnings of $0.04 which beat estimates for a loss of $0.12 and were up 111% from the same quarter last year. Revenue came in at $140.20 million compared to some forecasts for near $122 million.
AT last traded at $5.36 and has touched $5.44, with a 52-week range of $4.44 to $15.18.
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Xperia Football Cancellation
We took out the biggest noise we
could find during the World Cup
– football itself
Xperia Z2 is the first smartphone with Digital Noise Cancellation. As official partner of the FIFA World Cup 2014, Sony wanted to reach both the ones who love the game, and the ones who don't. Together with Sweden's biggest news site, Aftonbladet, we developed Xperia Football Cancellation, a button that gave people an opportunity to take out the biggest noise there is during the World Cup – football itself.
Agency: CP+B Stockholm
My role: Art Director and Designer
Awards and press:
Eurobest – Interactive, Online Ad, WEB BANNER, Bronze
Epica Awards – World Cup Advertising, Silver
London International Awards – Digital Banners, Bronze Winner
Best Ads – Best interactive of the week
Resumé – Digital campaign of the month, Gold


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Welcome to Arbor Village
Apartments in Gulfport, Mississippi
At Arbor Village Apartment Homes you will come home to a place you deserve. Arbor Village combines upscale living and serene surroundings that give you an enjoyable, comfortable living environment. Our lush landscaping, abundant amenities and superior customer service will surpass your expectations. Our apartments in Gulfport are conveniently located between Keesler Air Force Base and the Seabee Naval Base on Pass Road, and we are just minutes from casinos, beaches, shopping, dining and entertainment.


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True Pablove 2014 **TICKETS AVAILABLE AT DOOR**The Pablove FoundationSaturday, February 8, 2014 from 11:00 AM to 3:00 PM (PST) |
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
Yes! Tickets are available at the door for $75/person.
Join us for unique Valentine-themed arts and crafts, live music, a silent auction, kids' activities, and great food and beverages...all to fight childhood cancer with love.
Where can I contact the organizer with any questions?
Please email email@example.com with questions about registration, sponsorships or to contribute auction items. For more info about The Pablove Foundation visit pablove.org.
Can I pay by check?
Yes. If you received an invitation in the mail, please return your reply card with a check. You may also download this form and mail it to The Pablove Foundation at 6607 W. Sunset Blvd, Los Angeles, CA 90028.
Do I have to bring my printed ticket to the event?
Your printed ticket is not required, but your check-in process might go smoother if you bring a copy.
Is my ticket refundable?
No. All donations and registrations processed are non-refundable.
Is my ticket transferrable?
Yes. If you would like to transfer your tickets to a different name please contact The Pablove Foundation at 323.657.5557.
Is my ticket tax-deductible?
No. If you would like to make a tax-deductible contribution to The Pablove Foundation in addition to attending this event as a ticketed guest, please consider one of our event sponsorships.
How do I get there?
View a map of 613 Imperial Street.
Where do I park?
There is copious free street parking around Lot 613 (remember to observe all street signs). A $5/car lot is available at 1345 East 6th Street, which is a 0.1 mile walk from the venue – The Pablove Foundation does not have authority over this or any public lots. Please remember to carpool and be green!
The Pablove Foundation is a 501(c)(3) public charity, IRS Tax ID 26-3006100.
All donations are tax-deductible as allowed by law.
When & Where
Lot 613 in the Downtown Arts District
613 Imperial St
Los Angeles,
Saturday, February 8, 2014 from 11:00 AM to 3:00 PM (PST)
Add to my calendar
The Pablove Foundation
At The Pablove Foundation, we are driven by one simple vision:
Helping kids with cancer live—
a love-filled life today, and a cancer-free life tomorrow.
The Pablove Foundation is named after Pablo Thrailkill Castelaz, the son of Jo Ann Thrailkill and Jeff Castelaz and the little brother of Grady Gallagher. Pablo was six years old when he lost his valiant yearlong battle with bilateral Wilms Tumor, a rare form of childhood cancer. With the love of our community, The Pablove Foundation's mission continues to grow as we:
• Invest in underfunded, cutting-edge pediatric cancer research
• Inspire cancer families through education
• Improve the lives of children living with cancer through the arts
Add it all together, and it's what we call fighting childhood cancer with love.
Where do I park?
There is copious free street parking around Lot 613 (remember to observe all street signs). A $5/car lot is available at 1345 East 6th Street, which is a 0.1 mile walk from the venue – The Pablove Foundation does not have authority over this or any public lots. Please remember to carpool and be green!
Will tickets be available at the door?
Tickets will be available at the door for $75/each. (Online ticketing at $60/ticket ends at noon on Friday, February 7.)
How do I confirm the number of tickets I purchased?
Please call Ruth Chun at 323.657.5557 before 5:00pm on Friday if you have questions about your order.
Get your imaginations geared up for:
♥ Cookie decorating
♥ Make-your-own instruments
♥ Handcut silhouettes
♥ Custom Converse
♥ Tassel crafts (plus Clare Vivier)
♥ and SO much more!
What is in the silent auction?
You won't want to miss:
♥ Artwork and photography by Shepard Fairey, Geoff McFetridge, Lauren Greenfield, and many more
♥ Family getaways to the California coast, a Montana cabin, and Mammoth Mountain
♥ Homewares from Kelly Lamb, Heather Taylor, and Le Feu de L'Eau (to name a few!)
♥ Goodies for attendees of every age, from lego baskets and Disneyland tickets, on up to Tory Burch handbags and LA Film Festival passes...get the full sneak peak online!
Bid early online for exclusive experiences like a private dinner for 12 at a.o.c. or a meet + greet with Katy Perry at charitybuzz.com/support/Pablove.
When do the bands play?
11:45 a.m.-12:30 p.m. – DidiPop
1:30 p.m.-2:00 p.m. – Rhythm Child
All Day – DJ sets from sodapop + The One AM Radio


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A proposal for a new Houston Astros/Washington Nationals spring-training complex in Palm Beach County is back from the dead after West Palm Beach officials say they'll look closely at a previously rejected land swap.
Tag Archives | houston astros
Land swap could lead to new Astros/Nats spring training complex
Astros, Hooks to play exhibition game
We're still seeing changes and additions to the spring-training schedule, and here's another: The Houston Astros and Corpus Christi Hooks (Class AA; Texas League) will play an exhibition game at Whataburger Field on April 2.
Astros 2015 spring training schedule posted
We've posted the Houston Astros 2015 spring training schedule for home games at Osceola County Stadium and some away games.
West Palm Beach deals another blow to new spring training complex
West Palm Beach city commissioners approved a three-month exclusive negotiating period to investors seeking a mixed-use development on a 160-acre site eyed by the Houston Astros and Washington Nationals for a new spring-training facility.
Astros, Nats spring complex shot down by West Palm Beach
The proposed West Palm Beach site for a new Houston Astros/Washington Nationals spring-training facility will instead be used for a mixed-use development, as local elected officials decide to keep the land on the tax rolls.
Astros, Nats expected to propose new Palm Beach County spring training plan shortly
The Houston Astros and Washington Nationals are expected to submit a revised plan for a new Palm Beach County spring training complex in the next few weeks, as the pair are working to finalize arrangements by the end of the year.
New site emerging for Toronto Blue Jays spring training in Dunedin
We have a site for a potential new complex for Toronto Blue Jays spring training in Dunedin, with city officials eying a former Nielsen Media land parcel for a ballpark, clubhouses and practice field.
Palm Beach County to move forward with new 'Stros, Nats spring complex
Palm Beach County Commissioners voted to move ahead with a $100-million plan for a new Houston Astros and Washington Nationals spring-training complex, but lots of work needs to be done on the funding plan.
Will the Toronto Blue Jays stay in Dunedin?
A recent news report suggests that the Toronto Blue Jays may bail out of a proposed spring-training facility to be shared with the Houston Astros, but with plans still up in the air it's hard to predict where things will be in five years.
Houston Astros Arizona site is viable alternative to Florida complex: team official
In what we're considering now as a rather crude negotiating maneuver, team officials say they'll look at a Houston Astros Arizona move if a suitable training site in Palm Beach County fails to materialize.
First Spring Training Game!
- Mesa, A's to celebrate Hohokam Stadium reopening January 26, 2015
- Goodbye Cubs Park; hello Sloan Park January 8, 2015
- Cubs game times, reporting dates added January 6, 2015
- Roger Dean Stadium's Fan Fest set for Friday January 5, 2015
- Land swap could lead to new Astros/Nats spring training complex January 5, 2015
- Mesa: Cubs, ASU need to agree on ballpark lease September 28, 2012
- Lee County to pitch Nats again on City of Palms Park August 22, 2013
- Atlanta Braves to visit Rome Braves at end of spring training August 28, 2013
- Developer holds key to luring Nats to City of Palms Park August 29, 2013
- Lee County begins overhaul of Twins spring training complex September 4, 2013
Touring the Spring Training Camps
Cactus League
Arizona Diamondbacks
Chicago Cubs
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Cleveland Indians
Colorado Rockies
Kansas City Royals
Los Angeles Angels of Anaheim
Los Angeles Dodgers
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Cactus League Master Schedule
Grapefruit League
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Baltimore Orioles
Boston Red Sox
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Houston Astros
Miami Marlins
Minnesota Twins
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New York Yankees
Philadelphia Phillies
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Grapefruit League Master Schedule
Spring Training Ballparks
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Camelback Ranch-Glendale
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Goodyear Ballpark
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Salt River Fields at Talking Stick
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Cactus League Master Schedule
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Bright House Field
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McKenchnie Field
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Grapefruit League Master Schedule


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Lobbyists representing Hess Corp, 2011:
Lobbying Firm Hired | Amount | Subsidiary (Lobbied For) | Lobbyist |
Akin, Gump et al | $400,000 | Hess Corp |
D'Arcy, Sean G Fitzgerald, Jayne T Goode, Chris Johnson, Charles W IV McMillen, Jeffrey Terhune, Henry A Tucker, James R Jr |
Delta Strategy Group | $200,000 | Hess Corp |
Driscoe, Lara Harper, Graham Newsome, Jim Parsons, Scott |
Federal Policy Group | $180,000 | Hess Corp |
Dolan, Matthew J Heflin, Jay Kies, Kenneth J |
Ogilvy Government Relations | $480,000 | Hess Corp |
Berman, Wayne L Daly, Justin Dow, De'ana Giblin, Chris Hogan, J Michael Maloney, Drew Mercado, Moses O'Neill, John J Taylor, Gordon Thompson, Ryan Tompkins, Elena G |
*Each quarterly filing is treated as a separate report.
Feel free to distribute or cite this material, but please credit the Center for Responsive Politics. For permission to reprint for commercial uses, such as textbooks, contact the Center.


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Comfort Inn & Suites 333 Roberts Street East Hartford, CT 06108 Phone: (860) 289-4950 Fax: (860) 761-0391 |
Arts & Museums
»Connecticut Science Center
The Connecticut Science Center is where kids can get immerse themselves in Forensics, Physics, Astronomy and Geology, by spending time in the stunning 3-D theater and educational laboratories. Over 150 interactive exhibits are up for viewing. Parts of the venue can be hired for children's birthday parties, seminars and luncheons where catering is taken care of. Check website for more details.
»Museum of Natural and Other Curiosities
Started in 1796, way before Ripley's came into the picture, Joseph Steward, a painter and a museum curator, put up a small exhibition of his curiosity cabinet. The collection became so popular that Mr. Steward had to shift it to a much bigger mansion. Reopened to the public in the '90s, the museum now features rare oddities like peculiar birds, a huge lobster claw, a scary mummified hand, most of which were a part of Steward's original collection. The newest addition and perhaps, the most fascinating of them all is a stuffed two-headed calf that steals the show.
»Old State House
One of the nation's oldest state houses, Hartford's Old State House dates back to 1796 and is on the site of the original structure built in 1637. A Federal-style building designed by famed architect Thomas Bulfinch, the Old State House has been restored on numerous occasions and has been on the list of National Historic Landmarks since 1966. Even though it has not served the Connecticut government since the construction of the new State Capitol building since 1872, the Old State House is a must-see for families and those interested in the history of the Constitution State.
»Wadsworth Atheneum Museum of Art
One of the best museums in the Northeast, the Wadsworth Atheneum Museum of Art houses some of the finest small collections of European art in the country. Fine Renaissance and Modern art by Caravaggio, Lorrain, Picasso, Degas, Cézanne, van Dyck, Monet, Van Gogh and Manet line the walls. One of the most outstanding collections at the museum is that of the Hudson River School and late 19th-century oil and watercolors from local artists. Open since 1842, the Wadsworth Atheneum Museum of Art is the oldest public art museum in the United States.
»CRRA Trash Museum
The Trash Museum in Hartford lets you take recycling and reusing to the extreme! This one-of-a-kind museum informs visitors of the history of garbage removal as well as watch live feed of the CRRA's recycling program.
»Wadsworth Atheneum Museum of Art
"America's oldest public art museum," this world-renowned museum's collections of more than 45,000 works of art include Hudson River School landscapes, Old Master paintings, modernist masterpieces, French and American Impressionist paintings, Meissen and S
»Butler-McCook House & Garden
Located in Hartford's Downtown neighborhood, Butler-McCook House & Garden is one of the oldest in the city. Established in 1782, the home was designed by Jacob Weidenman. A pretty Victorian garden surrounds the back of the home. The home was owned by the Butler and McCook family for two centuries. Butler-McCook House & Garden functions as a museum, with exhibits reflecting the four generations that lived in this house, and the changes that the neighborhood saw over the years. The home has been retained as it was originally built, along with its interior decor.
»Pump House Gallery
Tudor designed English cottage that is actually a working pump house and an art gallery. It's the only public gallery in a municipal park in Connecticut.
»Connecticut River Museum
In the scenic Middlesex County town of Essex is the Connecticut River Museum, home to collections and exhibits dedicated to the history of the Connecticut River. Enjoy one of the many exhibits or enroll the kids in one of their many summer programs that encourage young students to study and respect the River's habitats. Drive to the museum, or arrive in your boat and disembark on the dock.
»Museum of Connecticut History
A collection of many firearms, changing exhibits, and portraits of the governor. The main focus of the exhibits are Connecticut's government, military, and industrial history.
»Connecticut State Library
Connecticut State Library is located in Hartford, Connecticut. It is an executive branch agency of the state and is also the library of Connecticut. It provides a host of facilities to its citizens like a library, information, archives, public records, a museum, and administrative services. It also extends its service to students, researchers, as well as public libraries and town governments throughout the state.
»Harriet Beecher Stowe Center
The Harriet Beecher Stowe Center is dedicated to the author of Uncle Tom's Cabin and offers tours for history buffs and even specially designed ones for children. This is the home in which Stowe lived from 1873 until her death in 1893. The house includes authentic, restored furniture pieces as well as souvenirs from her journeys around the world. A library, located on the grounds of the nearby Day House contains books, manuscripts, images and more. Enjoy eight Victorian gardens on the grounds of the estate as well as several special events held throughout the year.


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Mattis to CENTCOM
- By Thomas E. RicksThomas E. Ricks covered the U.S. military for the Washington Post from 2000 through 2008.
Marine Gen. James Mattis is going to take over the Central Command post from Petraeus, Defense Secretary Gates just announced.
This is the best news I have heard in a long time. Just when I think Gates has lost his touch, he revives my faith by doing something like this. Readers of this blog will know that I think Mattis is terrific.


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Major League Baseball | ||||||||||||||||||||||||||||||||||||||||
· News · Current Odds · Gaming Matchups · Live Odds · Pitching Report Cards · Probable Pitchers · Scoreboard · Statistics · Teams Index · Transactions · Weather · College Baseball · Minor League Baseball |
American League · Injuries · Power Poll · Previews · Recaps · Rotations · Schedule · Standings · Statistics |
National League · Injuries · Power Poll · Previews · Recaps · Rotations · Schedule · Standings · Statistics |
(Friday, March 1st) Final Score: Houston 8, St. Louis 8 Kissimmee, FL (Sports Network) - Brandon Laird led off the ninth with a home run and Delino DeShields Jr. scored the game-tying run on a wild pitch, as the Houston Astros and St. Louis Cardinals played to an 8-8 tie on Friday in spring training action. Chris Carter clubbed a two-run blast and Brandon Barnes added a solo shot for the Astros, who saw starter Bud Norris allow two runs on two hits and a walk over three full frames. Adron Chambers belted a three-run shot, while Pete Kozma and Daniel Descalso each plated a pair of runs for the Cardinals. St. Louis starter Joe Kelly walked two over two scoreless innings. 03/01 16:49:21 ET Powered by The Sports Network. |


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21 Perfect Christmas Presents for Her
Wrap up something as special as she is: chic accessories, cozy treats, and cool kitchen accoutrements.
15 Lightened-Up Desserts to Make Tonight
Enjoy sweet treats without over-indulging with these healthy desserts.
17 Crafts To Get You Ready for Fall
Fashion your home for fall with these easy DIYs, perfect for cooler weather.
Scoop up amazing deals at the Country Living Fair
Join us in Rhinebeck, Columbus, or Atlanta for scads of vintage scores, plus gorgeous new jewelry, bags, dresses, and more.
Where you see only sparse pantry staples, she envisions an unforgettable dinner. Give a host who reigns over the range these copper measuring spoons to add some shine to her next meal prep.
($16, westelm.com)
Recipes & Food
Crafts & DIY Projects
©2015 Hearst Communications, Inc. All Rights Reserved. Being Green • Why did I get this ad?


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Narrow your search
Carnegie Mellon University showed off their newest creation this week: a robot with six incredibly articulate and stable legs. Even a hard shove by a human leg can't stop this thing, but we'll tell you why this kind of robot could be great for search and rescue.
On today's show, we take a look at a terrifying new robot with snake-bots for legs, cheer Sony's plans to actually release "The Interview," and watch ancient Greek art come to life with the help of some clever animations.
Behind the scenes: What happens when you wear a biosensor to the movies? CNET's Stephen Shankland traveled to Cannes to find out.
Get this, now there's a nightmare-inducing ride that will angle you out 30 degrees while you're 94 floors above Chicago. What will they think of next?
In an excerpt from a new book about Apple after Steve Jobs, little emerges that many hadn't already suspected.
Google has confirmed it's acquired a company that makes robots for the military. But what's it planning?
Amazon has outlined a terrifying future in which computer-controlled octocopters will deliver low-weight goods to your door in less than 30 minutes.
Technically Incorrect: A customer who tries to cancel cable service receives a bill with a new first name.
Find out what you should add to your watch list because these videos are either brand new or going offline very soon.
In "Unfriended," an anonymous Skype user seeks revenge on those who drove a friend to kill herself by posting a video to YouTube. It's scary because it's easy to imagine the scenario really playing out.


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Secretary of Defense Leon E. Panetta and Deputy Secretary of Defense Ashton B. Carter have no public or media events on their schedules.
Deputy Assistant Secretary of Defense (Press Secretary) George Little and Acting Deputy Assistant Secretary of Defense (Media Operations) Capt. John Kirby will conduct a press briefing at 2 p.m. EST in the Pentagon Briefing Room (2E973). Journalists without a Pentagon building pass will be picked up at the River Entrance only. Plan to arrive no later than 45 minutes prior to the event; have proof of affiliation and two forms of photo identification. Please call 703-697-5131 for escort into the building.
The U.S. Army's third annual sustainability report shows a 17.2 percent reduction in accidental military fatalities, and a 12.6 percent decrease in civilian lost time and fatal claims during fiscal 2009.
The Department of Defense and the Office of Military Commissions will provide seats for news media aboard military chartered aircraft for travel to Naval Station Guantanamo Bay, Cuba, on Jan. 16, 2012, to cover a military commissions motions...
Check Other Events for additional listings, including air shows, band concerts, Congressional hearings, reunions and much more.
DoD News Now: 1500 January 26, 2015
℠2015 – National Guardsmen prepare to respond to a massive winter storm, the...
New System Allows Safer Transport of Contagious Patients
℠2015 – TRANSCOM unveils a new system to transport highly contagious patients.
DoD News Now: January 26, 2015
℠2015 – The National Guard deploys as a major storm threatens the Northeast, ...
Army Discusses Priorities in Europe
℠2015 - Leaders meet in Wiesbaden, Germany to look at future needs.
Contacts Additions and corrections for Today in the Department of Defense are invited and should be directed to the press desk by calling +1 (703) 697-5131 or +1 (703) 697-5132.
Media Questions News media representatives with questions for the Department of Defense may reach our press desk by calling +1 (703) 697-5131. Media representatives with questions after work hours should call +1 (703) 678-6162 for assistance.
Public Inquiries All others are invited to contact our public inquiries section by phone or U.S. mail or through the web. See our comment page for details.


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- Featured
- Newest
- Price
- Apt. Communities
Showing based on selected map area. Don't limit my results by the map.
Summary for Denver
Average price per square foot for Lakewood CO was $179, an increase of 3.5% compared to the same period last year. The median sales price for homes in Lakewood CO for Oct 14 to Jan 15 was $245,000 based on 626 home sales. Compared to the same period one year ago, the median home sales price decreased 1.2%, or $3,000, and the number...


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Publications (23)19.62 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: Anti-adipogenic and anti-obesity effects of a green coffee been extract (GCE) from unroasted Coffea canephora Robusta beans were investigated in vitro and in vivo. Insulin-induced adipogenesis in 3T3-L1 preadipocytes was inhibited by 25.6 and 87.9% following treatment with 100 and 500 μg/mL GCE, respectively. Expression of adipogenesis-specific genes was down-regulated. Body weight gains of C57BL/6 mice fed a high-fat diet (HFD) were suppressed in a concentration-dependent manner using GCE (0.3 or 1% in the diet), exhibiting a marked lower gain in 1% GCE-fed mice than in normal diet-fed animals. Decreases in body fat weights and the size of adipocytes were confirmed. GCE supplementation reduced concentrations of blood lipids and leptin, and attenuated hepatic steatosis. GCE inhibits adipogenesis by modulating cell signaling and improves dietary obesity by reducing lipid accumulation and the size of adipocytes.Food science and biotechnology 12/2014; 23(6). · 0.66 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1×10(9) CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10 or 100 mg/kg FEMY-R7 for 2 weeks. In Campylobcter-like organism-detection test, FEMY-R7 markedly reduced the urease-positive reactivity. In a clinical sudy, human subjects, confirmed to be infected with Helicobacter pylori, were orally administered twice a day with a capsule containing 150 mg FEMY-R7 for 8 weeks. FEMY-R7 significantly decreased both the Delta over baseline-value in urea breath test and the serum pepsinogens I and II levels. The results indicate that FEMY-R7 not only eliminates H. pylori from gastric mucosa of animals and humans, but also improves gastric function.Laboratory animal research. 09/2014; 30(3):131-5. - [Show abstract] [Hide abstract]
ABSTRACT: The effects of an ethanolic extract of Angelica gigas (EAG) on the vascular smooth muscle cell (VSMC) proliferation and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis were investigated. Rat aortic VSMCs were stimulated with platelet-derived growth factor-BB (25 ng/mL) for the induction of DNA synthesis and cell proliferation. EAG (1-10 µg/mL) significantly inhibited both the thymidine incorporation and cell proliferation in a concentration-dependent manner. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 0.5% cholesterol in diet for 10 weeks, during which EAG (1% in diet) was given for the final 8 weeks after 2-week induction of hypercholesterolemia. Hypercholesterolemic rabbits exhibited great increases in serum total cholesterol and low-density lipoproteins (LDL) levels, and finally severe atheromatous plaque formation covering 28.4% of the arterial walls. EAG significantly increased high-density lipoproteins (HDL), slightly decreased LDL, and potentially reduced the atheroma area to 16.6%. The results indicate that EAG attenuates atherosclerosis not only by inhibiting VASC proliferation, but also by increasing blood HDL levels. Therefore, it is suggested that EAG could be an alternative or an adjunct therapy for the improvement of hypercholesterolemia and atherosclerosis.Laboratory animal research. 06/2014; 30(2):84-9. - [Show abstract] [Hide abstract]
ABSTRACT: Objectives Since oils and fats can induce metabolic syndrome, leading to cardiovascular and cerebrovascular diseases, the present study was performed to find out whether the plant oils affect the cerebral hemorrhage in stroke-prone spontaneously hypertensive (SHR-SP) rats. Methods From 47 days of age, male SHR-SP rats were given drinking water containing 1% NaCl to induce hypertension, and simultaneously fed semi-purified diets containing 10% perilla oil, canola oil, or shortening. The onset time of convulsion following cerebral hemorrhage was recorded, and the areas of hemorrhage and infarction were analyzed in the stroke brains. Results In comparison with 58-day survival of SHR-SP rats during feeding NaCl alone, perilla oil extended the survival time to 68.5 days, whereas canola oil shortened it to 45.7 days. Feeding perilla oil greatly reduced the total volume of cerebral hemorrhage from 17.27% in the control group to 4.53%, while shortening increased the lesions to 21.23%. In a microscopic analysis, perilla oil also markedly decreased the hemorrhagic and infarction lesions to 1/10 of those in control rats, in contrast to an exacerbating effect of shortening. In blood analyses, perilla oil reduced blood total cholesterol and low-density lipoproteins which were increased in SHR-SP, but canola oil further increased them and markedly lowered platelet counts. Discussion Perilla oil delayed and attenuated cerebral hemorrhage by improving hyperlipidemia in hypertensive stroke animals, in contrast to the aggravating potential of canola oil and shortening. It is suggested that perilla oil should be the first choice oil for improving metabolic syndrome in hypertensive persons at risk of hemorrhagic stroke.Nutritional Neuroscience 05/2014; · 2.11 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Effects of FEMY-R7, composed of fucoidan and evening primrose extract, on the bacterial growth and intragastric infection of Helicobacter pylori as well as gastric secretion were investigated in comparison with a proton-pump inhibitor pantoprazole. For in vitro anti-bacterial activity test, H. pylori (1×10(8) CFU/mL) was incubated with a serially-diluted FEMY-R7 for 3 days. As a result, FEMY-R7 fully inhibited the bacterial growth at 100 µg/mL, which was determined to be a minimal inhibitory concentration. In addition, 6-hour incubation with H. pylori, FEMY-R7 inhibited urease activity in a concentration-dependent manner, showing a median inhibitory concentration of 1,500 µg/mL. In vivo elimination study, male C57BL/6 mice were infected with the bacteria by intragastric inoculation (5×10(9) CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10, 30 or 100 mg/kg FEMY-R7 for 7 days. In Campylobcter-like organism-detection test and bacterial identification, FEMY-R7 exerted a high bacteria-eliminating capacity at 30-100 mg/kg, comparably to 30 mg/kg pantoprazole. In contrast to a strong antacid activity of pantoprazole in a pylorus-ligation study, FEMY-R7 did not significantly affect gastric pH, free HCl, and total acidity, although it significantly decreased fluid volume at a low dose (10 mg/kg). The results indicate that FEMY-R7 eliminate H. pylori from gastric mucosa by directly killing the bacteria and preventing their adhesion and invasion, rather than by inhibiting gastric secretion or mucosal damage.Laboratory animal research. 03/2014; 30(1):28-34. -
Article: Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation.
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ABSTRACT: The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma was incubated with perilla oil and aggregation inducers collagen or thrombin, and the platelet aggregation rate was analyzed. Perilla oil significantly inhibited both the collagen- and thrombin-induced platelet aggregations, in which the thromboxane B2 formation from collagen-activated platelets were reduced in a concentration-dependent manner. Rats were administered once daily by gavage with perilla oil for 1 week, carotid arterial thrombosis was induced by applying 35% FeCl3-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Perilla oil delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. In addition, a high dose (2 mL/kg) of perilla oil greatly prevented the occlusion, comparable to the effect of aspirin (30 mg/kg). The results indicate that perilla oil inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is proposed that perilla oil could be a good candidate without adverse effects for the improvement of blood flow.Laboratory animal research. 03/2014; 30(1):21-7. - [Show abstract] [Hide abstract]
ABSTRACT: The effects of nattokinase on the in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin. Rabbit platelet-rich plasma was incubated with nattokinase and aggregation inducers collagen and thrombin, and the platelet aggregation rate was analyzed. Nattokinase significantly inhibited both the collagen- and thrombin-induced platelet aggregations. Nattokinase also reduced thromboxane B2 formation from collagen-activated platelets in a concentration-dependent manner. Rats were orally administered with nattokinase for 1 week, and their carotid arteries were exposed. Arterial thrombosis was induced by applying 35% FeCl3-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Nattokinase delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 160 mg/kg. In addition, a high dose (500 mg/kg) of nattokinase fully prevented the occlusion, as achieved with aspirin (30 mg/kg). The results indicate that nattokinase extracted from fermented soybean inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is suggested that nattokinase could be a good candidate without adverse effects for the improvement of blood flow.Laboratory animal research. 12/2013; 29(4):221-5. - [Show abstract] [Hide abstract]
ABSTRACT: The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.Biomolecules and Therapeutics 11/2013; 21(6):454-461. · 0.84 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Aging is characterized by progressive loss of cognitive and memory functions as well as decrease in physical activities. In the present study, a human neural stem cell line (F3 NSC) over-expressing choline acetyltransferase (F3.ChAT), an enzyme responsible for acetylcholine synthesis, was generated and transplanted in the brain of 18-month-old male ICR mice. Four weeks post-transplantation, neurobehavioral functions, expression of ChAT enzyme, production of acetylcholine and neurotrophic factors, and expression of cholinergic nervous system markers in transplanted animals were investigated. F3.ChAT NSCs markedly improved both the cognitive function and physical activity of aging animals, in parallel with the elevation of brain acetylcholine level. Transplanted F3 and F3.ChAT cells were found to differentiate into neurons and astrocytes, and to produce ChAT proteins. Transplantation of the stem cells increased brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), enhanced expression of Trk B, and restored host microtubule-associated protein 2 and cholinergic nervous system. The results demonstrate that human NSCs over-expressing ChAT improve cognitive function and physical activity of aging mice, not only by producing ACh directly but also by restoring cholinergic neuronal integrity, which might be mediated by neurotrophins BDNF and NGF.Neurobiology of aging 05/2013; · 5.94 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: According to a high anti-osteoporotic efficacy of Sigma Anti-bonding Molecule Calcium Carbonate (SAC), repeated-dose toxicities of SAC were investigated to assess its feasibility as drug or functional food ingredient. Male ICR mice were given drinking water containing 0.006, 0.02 or 0.06% SAC for 4 weeks. SAC feeding decreased the body weights and feed and water consumptions of mice in a dose-dependent manner, especially, leading to severe emaciation and 70% death in 3 weeks in the high-dose (0.06%) group. Not only kidney and heart weights, but also the levels of blood urea nitrogen, creatinine, aspartate transaminase, and creatine phospokinase significantly increased after SAC administration, indicative of nephrotoxicity and cardiotoxicity. Such renal and cardiac toxicities were also confirmed by microscopic findings, exhibiting renal crystals and cardiac fibrosis, which may be due to the insoluble crystal formation and calcium overload, respectively. In conclusion, it is suggested that no observed adverse effect level of SAC is lower than 0.006% in mice, and that a long-term intake may cause serious adverse effects on renal and cardiac functions.Laboratory animal research. 03/2013; 29(1):7-11. - [Show abstract] [Hide abstract]
ABSTRACT: Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intravenously (1 × 10(6) cells) or intracerebroventricularly (4 × 10(5) cells) transplanted into the brains of 18-month-old mice once or four times at 2-week intervals. Transplantation of ADMSCs improved both locomotor activity and cognitive function in the aged animals, in parallel with recovery of acetylcholine levels in brain tissues. Transplanted cells differentiated into neurons and, in part, into astrocytes and produced choline acetyltransferase proteins. Transplantation of ADMSCs restored microtubule-associated protein 2 in brain tissue and enhanced Trk B expression and the concentrations of brain-derived neurotrophic factor and nerve growth factor. These results indicate that human ADMSCs differentiate into neural cells in the brain microenvironment and can restore physical and cognitive functions of aged mice not only by increasing acetylcholine synthesis but also by restoring neuronal integrity that may be mediated by growth/neurotrophic factors. © 2013 Wiley Periodicals, Inc.Journal of Neuroscience Research 02/2013; · 2.73 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The anti-obesity activities of Rapha diet® preparation containing silkworm pupa peptide, Garcinia cambogia, white bean extract, mango extract, raspberry extract, cocoa extract, and green tea extract were investigated in mice with dietary obesity. Male C57BL/6 mice were fed a high-fat diet (HFD) containing 3% Rapha diet® preparation for 8 weeks, and blood and tissue parameters of obesity were analyzed. The HFD markedly enhanced body weight gain by increasing the weights of epididymal, perirenal, and mesenteric adipose tissues. The increased body weight gain induced by HFD was significantly reduced by feeding Rapha diet® preparation, in which decreases in the weight of abdominal adipose tissue and the size of abdominal adipocytes were confirmed by microscopic examination. Long-term feeding of HFD increased blood triglycerides and cholesterol levels, leading to hepatic lipid accumulation. However, Rapha diet® preparation not only reversed the blood lipid levels, but also attenuated hepatic steatosis. The results indicate that Rapha diet® preparation could improve HFD-induced obesity by reducing both lipid accumulation and the size of adipocytes.Laboratory animal research. 12/2012; 28(4):265-71. -
Article: Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract.
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ABSTRACT: The anti-inflammatory effects of fuciodan and Cistanche tubulosa (CT) extract were investigated in vitro macrophage culture system and in vivo carrageenan-induced air pouch inflammation model. CT extract inhibited nitric oxide production from activated RAW 264.7 macrophage cells, while fucoidan was inactive. In vivo air pouch inflammation model, carrageenan-induced vascular exudation and increased nitric oxide and prostaglandin E(2) concentrations in the exudates were synergistically suppressed by co-administration of fucoidan or CT extract. Moreover, tissue inflammation was substantially attenuated by the combinational therapy. However, there was no synergistic effect against the inflammatory cell infiltration, although fucoidan and CT extract each markedly reduced the cell numbers. Therefore, it is suggested that fucoidan blocks infiltration of inflammatory cells, while CT extract inhibits activation of the cells, and that their combinational treatment could be a promising candidate for the relief of various types of inflammation.Laboratory animal research. 06/2012; 28(2):91-7. - [Show abstract] [Hide abstract]
ABSTRACT: Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-α (TNF-α) and nitric oxide (NO), as well as prostaglandin E(2) (PGE(2)). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased PGE(2). The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase-2-PGE(2) pathways.Laboratory animal research. 06/2012; 28(2):137-40. - [Show abstract] [Hide abstract]
ABSTRACT: The effects of polarized-light therapy (PLT) on high-cholesterol diet (HCD)-induced hypercholesterolemia and atherosclerosis were investigated in comparison with that of lovastatin in rabbits. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 1% cholesterol in diet for 2 weeks and maintained with 0.5% cholesterol for 6 weeks, followed by normal diet for 2 weeks for recovery. Lovastatin (0.002% in diet) or daily 5-min or 20-min PLT on the outside surface of ears was started 2 weeks after induction of hypercholesterolemia. Hypercholesterolemic rabbits exhibited great increases in serum cholesterol and low-density lipoproteins (LDL) levels, and finally severe atheromatous plaques formation covering 57.5% of the arterial walls. Lovastatin markedly reduced both the cholesterol and LDL, but the reducing effect (47.5%) on atheroma formation was relatively low. By comparison, 5-min PLT preferentially decreased LDL, rather than cholesterol, and thereby potentially reduced the atheroma area to 42.2%. Notably, 20-min PLT was superior to lovastatin in reducing both the cholesterol and LDL levels as well as the atheromatous plaque formation (26.4%). In contrast to the increases in blood alanine transaminase and aspartate transaminase following lovastatin treatment, PLT did not cause hepatotoxicity. In addition, PLT decreased platelets and hematocrit level. The results indicate that PLT attenuates atherosclerosis not only by lowering blood cholesterol and LDL levels, but also by improving blood flow without adverse effects. Therefore, it is suggested that PLT could be a safe alternative therapy for the improvement of hypercholesterolemia and atherosclerosis.Laboratory animal research. 03/2012; 28(1):39-46. - [Show abstract] [Hide abstract]
ABSTRACT: Effects of egg york containing IgY specific for Helicobacter pylori on the bacterial growth and intragastric infection were investigated in comparison with a proton-pump inhibitor pantoprazole. For in vitro anti-bacterial activity test, H. pylori (1×10(8) CFU/mL) was incubated with a serially diluted IgY for 3 days. As a result, IgY fully inhibited the bacterial growth at 16 mg/mL, which was determined to a minimal inhibitory concentration. In vivo elimination study, male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1×10(8) CFU/mouse) 3 times at 2-day intervals, and 2 weeks later, orally treated twice a day with 50, 100, 200 or 500 mg/kg IgY for 18 days. After the final administration, biopsy sample of the gastric mucosa was assayed for the bacterial identification via urease, oxidase, catalase, nitrate reduction and H(2)S tests in addition to microscopic examination for mucosal inflammation. In CLO kit test, 75, 50, 12.5 and 12.5% of the animals revealed positive reaction following treatment with 50, 100, 200 and 500 mg/kg IgY, respectively, resulting in a superior efficacy at 200 mg/kg than 30 mg/kg pantoprazole that displayed 75% elimination. The CLO test results were confirmed by bacterial identification. Microscopic examination revealed that H. pylori infection caused severe gastric mucosal inflammation, which were not observed in the CLO-negative mice following treatment with IgY or pantoprazole. Taken together, IgY inhibited the growth of H. pylori, and improved gastritis and villi injuries by eliminating the bacteria from the stomach. The results indicate that IgY could be a good candidate overcoming tolerance of antibiotics for the treatment of H. pylori-mediated gastric ulcers.Laboratory animal research. 03/2012; 28(1):55-60. - [Show abstract] [Hide abstract]
ABSTRACT: The study investigated the correlation between infarction areas and behavioural deficits in middle cerebral artery occlusion (MCAO) and photothrombosis stroke models. In the MCAO model, a 0.38 mm-diameter silicone-coated thread was introduced through the left external carotid artery and advanced 18 mm via the internal carotid artery to the origin of middle cerebral artery of male Sprague-Dawley rats weighing 300-350 g. The thread was removed for reperfusion after occlusion for 0.5, 1 or 2h. In the photothrombosis model, after a midline incision on the scalp, a focused light (10,000 lux, 6 mm-diameter) was delivered 1mm anterior to the bregma and 3mm left of the midline for 5, 10 or 20 min. During the first 2 min of irradiation, Rose Bengal dye (30 mg/kg) was injected intravenously. Twenty four hours post-surgery, the animals were subjected to neurological scoring and behavioural performances, and were sacrificed for macroscopic and microscopic examinations of brain injury. Total infarction volumes in the MCAO model rats increased in an occlusion time-dependent manner, while the infarction volumes in photothrombosis model rats plateaued relatively quickly with no time-dependent increase. The MCAO model displayed neurological scores and behavioural deficits that correlated well with infarction volumes, while relatively poor correlation between infarction volume and neurobehavioural abnormalities was evident in the photothrombosis model. The results indicate the suitability of the MCAO model for studies on preventive or therapeutic compounds related to functional recovery, although the photothrombosis model might be useful to generate focused lesions leading to the location-related behavioural changes.Environmental toxicology and pharmacology. 11/2011; 33(1):60-9. - [Show abstract] [Hide abstract]
ABSTRACT: Since cyclophosphamide is metabolically activated to teratogenic acrolein and cytotoxic phosphoramide mustard by cytochrome P-450 type 2B (CYP2B), we assessed the effects of licorice, a CYP2B inducer, on the fetal defects induced by cyclophosphamide. Pregnant Sprague-Dawley rats were daily administered with licorice (100 mg/kg) by gavage for 7 days, from the 6th to 12th day of gestation, and intraperitoneally administered with cyclophosphamide (11 mg/kg) 1 hr after the final licorice treatment. On the 20th day of gestation, maternal and fetal abnormalities were determined by Cesarian section. Cyclophosphamide was found to reduce fetal and placental weights without increasing resorption or death. In addition, it induced malformations in live fetuses; 93.8, 41.1, and 100% of the external (skull and limb defects), visceral (cleft palate and ureteric dilatation), and skeletal (acrania, vertebral/costal malformations, and delayed ossification) abnormalities, respectively. When pre-treated with licorice, cyclophosphamide-induced body weight loss and abnormalities of fetuses were remarkably aggravated. Moreover, repeated treatment with licorice greatly increased mRNA expression and activity of hepatic CYP2B. The results indicate that repeated intake of licorice may aggravate cyclophosphamide-induced body weight loss and malformations of fetuses by upregulating CYP2B.Birth Defects Research Part B Developmental and Reproductive Toxicology 08/2011; 92(6):553-9. · 1.97 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Periventricular leukomalacia, specifically characterized as white matter injury, in neonates is strongly associated with the damage of pre-myelinating oligodendrocytes. Clinical data suggest that hypoxia-ischemia during delivery and intrauterine or neonatal infection-inflammation are important factors in the etiology of periventricular leukomalacia including cerebral palsy, a serious case exhibiting neurobehavioral deficits of periventricular leukomalacia. In order to explore the pathophysiological mechanisms of white matter injury and to better understand how infectious agents may affect the vulnerability of the immature brain to injury, novel animal models have been developed using hypoperfusion, microbes or bacterial products (lipopolysaccharide) and excitotoxins. Such efforts have developed rat models that produce predominantly white matter lesions by adopting combined hypoxia-ischemia technique on postnatal days 1-7, in which unilateral or bilateral carotid arteries of animals are occluded (ischemia) followed by 1-2 hour exposure to 6-8% oxygen environment (hypoxia). Furthermore, low doses of lipopolysaccharide that by themselves have no adverse-effects in 7-day-old rats, dramatically increase brain injury to hypoxic-ischemic challenge, implying that inflammation sensitizes the immature central nervous system. Therefore, among numerous models of periventricular leukomalacia, combination of hypoxia-ischemia-lipopolysaccharide might be one of the most-acceptable rodent models to induce extensive white matter injury and ensuing neurobehavioral deficits for the evaluation of candidate therapeutics.Laboratory animal research. 06/2011; 27(2):77-84. -
Article: Increased nephrotoxicity after combined administration of melamine and cyanuric Acid in rats.
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ABSTRACT: Renal toxicity by melamine in combination with cyanuric acid (1:1) was investigated. Male rats were orally administered melamine plus cyanuric acid (5, 50 or 400 mg/kg each) for 3 days. In contrast to a negligible effect by melamine alone (50 mg/kg, a no-observed-adverse-effect-level: NOAEL), co-administration with cyanuric acid markedly increased the concentrations of blood urea nitrogen and creatinine, as well as kidney weight. A high dose (400 mg/kg) of melamine plus cyanuric acid induced more severe kidney toxicity. The increased blood parameters for kidney toxicity and organ weight lasted longer than 4 days. Combined treatment with melamine and cyanuric acid (50-400 mg/kg each) resulted in many gold-brown crystals and toxic lesions in renal tubules, which were not observed in animals treated with melamine alone (50 mg/kg). These results indicate that only a 3-day exposure to melamine in combination with cyanuric acid causes severe renal damage, even at a NOAEL for melamine found in a 13-week toxicity study. Therefore, it is suggested that the tolerable daily intake or regulatory/management levels of melamine need to be re-considered for cases of co-exposure with cyanuric acid.Laboratory animal research. 03/2011; 27(1):25-8.
Publication Stats
75 | Citations | |
19.62 | Total Impact Points | |
Top Journals
Chungbuk National University
- College of Veterinary Medicine
Tyundyu, North Chungcheong, South Korea


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Dr. Tessa M. Ricci, MD
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Dr. Tessa M. Ricci graduated from the University of South Florida College of Medicine at Tampa in 2000. She works in Jacksonville, FL and specializes in Family Medicine. Dr. Ricci speaks English and German.
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Years in Practice: 15 Years
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Medical School: University of South Florida College of Medicine at Tampa
Graduation Date: 2000
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Specialties: Family Medicine


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Daily award-winning interview and features program.
Originally published on Wed January 28, 2015 1:03 pm
In the years following the invasion of Iraq, it became a truism that Americans simply didn't want to hear about the war — especially at the movies. While there were scads of films about Iraq, including Kathryn Bigelow's Oscar-winning The Hurt Locker, none was able to attract a big audience. Until American Sniper.
Originally published on Wed January 28, 2015 12:42 pm
Teens can't control impulses and make rapid smart decisions like adults can — but why?
Research into how the human brain develops helps explain. In a teenager, the frontal lobe of the brain, which controls decision-making, is built, but not fully insulated — so signals move slowly.
"Teenagers are not as readily able to access their frontal lobe to say, 'Oh, I better not do this,' " Dr. Frances Jensen tells Fresh Air's Terry Gross.
Originally published on Wed January 28, 2015 4:46 pm
Between 1962 and 1965, The Beatles were featured on 53 BBC radio programs. For The Beatles: The BBC Archives, executive producer Kevin Howlett had to search for many of these recordings, and they weren't easy to find.
Originally broadcast Nov. 27, 2013.
Originally published on Mon January 26, 2015 12:17 pm
Almost Famous Women is the kind of "high concept" short-story collection that invites skepticism. These stories are about 13 historical women whose names you mostly might sort-of recognize. Beryl Markham, Butterfly McQueen and Shirley Jackson are slam-dunks, but Romaine Brooks and Joe Carstairs are a bit blurrier. While the family names of Allegra Byron, Dolly Wilde and Norma Millay betray their relation to important figures, we don't know what they did. And who the heck was Hazel Eaton or Tiny Davis?
Fresh Air Weekend highlights some of the best interviews and reviews from past weeks, and new program elements specially paced for weekends. Our weekend show emphasizes interviews with writers, filmmakers, actors, and musicians, and often includes excerpts from live in-studio concerts. This week:
New Orleans music didn't do as well in the 1960s, a few hits notwithstanding, as it had done. Musicians left town, major labels lost interest, and Motown and Memphis took over the black music charts. Nonetheless, the late Cosimo Matassa, who owned the only recording studio in town, kept busy. Fresh Air rock historian Ed Ward has the story today.
Originally published on Thu January 22, 2015 1:28 pm
When the Seattle Seahawks and New England Patriots meet in the 2015 Super Bowl on Feb. 1, the broadcast booth will be anchored by a man who has done the play-by-play for eight previous Super Bowls. Al Michaels, the announcer for NBC's Sunday Night Football, knows how to put emotion into his broadcasts.
In 2005, jazz composer and french horn player Tom Varner left New York for Seattle, where he put together a nine-piece band of local players. Their new album is called Nine Surprises. Fresh Air jazz critic Kevin Whitehead says that Varner can really write, and they can really play.