text:
Dr. Roland L. Chu, MD
Pediatric Hematology-Oncology, Childrens Hospital Michigan Emergency
- 3901 Beaubien St
Detroit, MI 48201 - 2 Office Locations
- (313) 745-5437
Dr. Roland L. Chu graduated from the Wayne State University School of Medicine in 1999. He works in Detroit, MI and 1 other location and specializes in Pediatric Hematology-Oncology. Dr. Chu is affiliated with Saint Joseph Mercy Oakland and Childrens Hospital Of Michigan. He speaks Chinese, English, French, German and Spanish.
Gender: Male
Years in Practice: 16 Years
Languages Spoken: Chinese, English, French, German, Spanish
Medical School: Wayne State University School of Medicine
Graduation Date: 1999
Hospital Affiliations: Saint Joseph Mercy Oakland, Childrens Hospital Of Michigan
Specialties: Pediatric Hematology-Oncology
*This physician has multiple office locations. See Appointments for details.


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TL : DR - Vlad doesn't really need work in my opinion, even though he is outshone by some other mages like Brand. If anything, he could use some increased CDR on his early Q (Transfusion), and some minor fixes to the confusing nature of his W (Sanguine Pool), but there's really nothing that glaringly wrong with Vlad. Over-nurfing or Over-buffing any piece of Vlad's kit has far reaching implications to the entire rest of his playstyle, and creative cooldown adjustments while keeping Vlad's damage numbers close to what they are now would provide Vlad a bit more of an edge versus his role's current competition.
Vlad has been my main for many many patches. I've seen him at the heights of his power and in his current state (which I don't really feel is all that under-powered as so many people seem to think). Vlad has some obvious and interesting issues early-game, but they aren't terribly challenging issues. This post will attempt to expound on my takes on Vlad as a champion, and provide some thoughts on possible directions his future development could take.
A Brief Overview of Vlad in 5v5
Vlad's best lane is a solo lane, be it mid or top. Vlad can do either well if the player knows how to be defensive. The main lane phase consists of rushing your Q (Transfusion) to max level as soon as possible, while taking ranks in W (Sanguine Pool) or E (Tides of Blood) as a secondary skill to max, depending on your strategy. Some Vlads attempt to play aggressive during the early levels, but I find that without a gank from Jungle or being against a careless lane opponent, it's very difficult to get a kill before you have R (Hemoplague).
My typical strategy is to buy a Doran's Shield, head to mid preferably, and play a last hit poking game with my lane opponent to get as close to tower as possible. From tower, with one rank in E (Tides of Blood) and a few ranks in Q (Transfusion), I can out-farm almost any typical middle lane, even sitting on the tower. It's very easy to learn how to play Vlad defensively while you need to farm Vlad is a preppy vampire aristocrat with expensive taste after all, and he does best if you can rush a Needlessly Large Rod and Boots with your first buy (my earliest first buy for both of those items was right around level 7).
As soon as I hit 9, i'm ready to push out middle and roam, because my Q (Transfusion) is at a low enough cooldown to effectively gank/harass/bully someone in bottom or top lane, or assist with Dragon fairly effectively. Hopefully I get a quick kill, or assist a lane in pushing a tower, and then I make my way back. If I got a kill, I'll usually go back to mid unless I'm below a quarter health. Vlad is great because even if he's low, unless your lane opponent can burst you down immediately, you can out-sustain if you just hug your tower right. If creeps are pushing too hard, Vlad's E/Q/W combo (Tides of Blood -> Transfusion -> Sanguine Pool) is a pretty effective wave clearer, but I usually make sure to keep the creeps up long enough to heal up to around half HP.
After this point, Vlad is pretty versatile. It really just comes down to build and play. Some people prefer to be very aggressive on Vlad lategame, which can be good. I prefer to play him as artillery, poking from the back or side of teamfights after dropping his R (Hemoplague). But that all really depends on your item build.
Item Builds
Vlad has two main concerns for his build; AP and HP. I prefer to focus on his AP, because his pool doesn't do much as far as consistent damage because the cooldown is so long.
You can build him defensively (which I prefer) and rush Zhonya's Hourglass to give yourself added survivability. This item also turns you into an incredibly baiting tool. If you pool towards your hiding team mates while being chased, you can pop Zhonya's after you emerge from your pool and your team initiates the gank.
You can also build Hextech Revolver to increase your sustain and damage, which combos well with Spirit Visage. This improves Vlad's sustain by massively increasing his healing capabilities. Popping Vlad's E (Tides of Blood) in a large creep wave or teamfight will heal you for more than the ability costs. Often with these items I can last indefinitely in the enemy's base during the endgame.
If you are building Vlad more offensive, you probably will want to rush Rabadon's, but I personally think Vlad is better off using his massive health to his advantage and being played more defensively in his current state.
I don't find HP items incredibly viable on Vlad, even considering his W (Sanguine Pool) stacks damage well with increased HP. The cooldown on his W simply doesn't make building HP to boost the pool's damage viable over buffing his AP to make his healing and sustain better from his Q (Transfusion) and E (Tides of Blood, if you build Hextech Revolver). The most HP I usually build on Vlad is a combo of Rylai's Scepter and Spirit Visage, but that's only if the game requires me to be playing incredibly conservative.
A Brief Overview of Vlad on Dominion
Vlad is great on Dominion. His consistent early-game nukes with his E (Tides of Blood) and his low cooldown poke and AoE late-game make him an awesome contributor to any fight. And that's not even mentioning how much 15% increased damage from his R (Hemoplague) does on Dominion, where characters are already hitting stupid damage heights never seen in Summoner's Rift. Even though Dominion reduces healing effects significantly, this only really seems to affect Vlad's early game, because his late game healing output is still pretty high if you build a humble amount of spell vamp.
I find that rushing Rylai's, followed by Will of the Ancients and then Zhonya's Hourglass makes you an incredibly mean fighter as well as tower defender. If you play right, and hit and run, you will be able to harass a lot of different characters that have currently been shutting people down as immovable tower guards.
I've dueled with Leona, Garen, Gangplank, Anivia, Akala, Alistar, Heimerdinger, Singed, and Mundo, ALL ON THEIR TOWER ON DOMINION, and STILL came out on top. Many of these were 2v1 situations. Because of the range on Vlad's Q (Transfusion) and E (Tides of Blood), Vlad is able to poke enemies, EVEN ON THEIR TOWER. It's a great counter to some of the turtles you see out there. Most of this is after you've reached level 9, because it requires you to be spamming fairly consistently and clearing out minions quickly, both of which Vlad excels at post 9.
Early game though, even despite Vlad's slow Q (Transfusion) ramp up, he can still be a threat if you effectively utilize his E (Tides of Blood). He can be a threat to anyone who's capping a point, whether they are doing it solo, duo, or whatever, as long as you can jump in there and range your AoE effectively. I've hit-and-run disrupted towers with Vlad very effectively, even versus as many as 3 opponents. It's not difficult, and it makes you an incredible asset to teams.
I wont cover Dominion build options in depth, because I haven't extensively tested too many alternative builds. I have been meaning to make note of the Hextech Sweeper though, because I think it could be a pretty mean item on Vlad. I'd really like to see a Hextech Sniper Rifle, built out of Revolver and Sweeper, so I wouldn't have to feel like I'm holding up a slot with an item which would be better filled with any number of other AP items.
Vlad has a strong set of abilities. Such a kit presents a problem to Riot, because balancing a kit of very powerful abilities all coupled with one another can make nurfing any of them seem as if they removing a core piece of Vlad, because they are mostly damage dealing abilities. Vlad doesn't really have CC, unless you're able to offensively use pool, which is always risky because of the cooldown until lategame. In this section, I'll explain each of Vlad's abilities and my perceptions of their pros and cons. I'm going to wait until the end of my posts before I say anything about how I think Vlad could be changed.
Passive - Crimson Pact
Every 40 points of bonus health gives Vladimir 1 ability power and every 1 point of ability power gives Vladimir 2 bonus health (does not stack with itself).
Vlad's passive is amazing. Since Vlad can't effectively make use of many of the items in the game designed for casters because he's not a mana-based champion, he needs an alternative means of generating value out of items. This passive does that very effectively. Build heavy AP and you're automatically beefy. Buy an HP item like Rylai's and you're not only increasing your CC, you're also increasing your AP and HP by more then the item would grant any other character.
The ratio has been nurfed a few times, but it makes sense. When the initial split of Zhonya's Ring occured, any Vlad who bought Rabadon's and Zhonya's was nearly unkillable. It was expensive, but the passive's ratio made it so easy to rick-roll people early, so it wasn't generally a problem to have both of these items before 25 minutes. All in all, the passive is solid. It doesn't really need work.
Q - Transfusion
Vladimir drains the lifeforce of his target, dealing 70 / 115 / 160 / 205 / 250 (+60% of ability power) magic damage and healing himself for 25% (+100% of ability power) of that amount.
Cooldown 8 / 7 / 6 / 5 / 4seconds
Range 550
This is Vlad's bread and butter ability. It's been tweaked more often and more drastically than any of the other abilities in his kit. Early in Vlad's history, this ability was game breakingly overpowered because of it's high damage and low cooldown. Lately, this ability has taken small hits to damage and a noticeable hit to it's lowest cooldown. Previously, with runes and items, you could get this ability to be castable on a 1.8 second cooldown, but now you can only get it down to 2.4 seconds.
This ability is problematic for a number of reasons to Riot. First off, there are two sets of numbers, each of which have unique AP ratios. Second off, it's Vlad's sustain ability and his most consistent source of damage endgame, both rolled into one. Thirdly, the ability is very powerful, so early-game it has to be balanced, which makes it seem weak early game, but necessary because the quicker you get it to 5, the quicker you can reach the ability's max utility.
I love this ability, and even with all of the nurfs, it's one of the most satisfying abilities in the game to use. It hits the target instantly. You don't have to wait for a projectile speed before your nuke demolishes the first part of their HP while your E (Tides of Blood) makes it's way over to them. It's great on any game mode, and it shines in Dominion, EVEN THOUGH one of the key aspects of the ability is fundamentally nurfed in that mode. I've reached a lot of turrets which were about to be fully capped, only to Q someone at the LAST SECOND to deny them the turret support.
W - Sanguine Pool
Vladimir sinks into a pool of blood for 2.5 seconds, becoming untargetable and slowing enemies above him by 40%.
Vladmir deals 15% of his bonus Health in magic damage over the duration and heals himself for 12.5% of that amount.
Cooldown 26/23/20/17/14 seconds
Cost 20percent of health
This is Vlad's escape, and it's one of the most infuriating escapes in the game to try to go against. This ability is essentially a steerable, slow motion, AoE flash. You can dodge projectiles, escape Lux's laser, be a scared little puddle of death if you get feared, or just troll just about any hero by pooling away from their main ability which was about to demolish you. This ability can also be used offensively if you are careful. The slow has been nurfed, but it's still viable if you are about to demolish someone with help from a gank/jungle. I use it often if I'm initiating a gank I've communicated to my team as a method of assisting my team mates as they close the gap.
This ability is also pretty complex and problematic for balance purposes.
-It deals Damage
-It slows
-It costs health
-It potentially heals if it damages enough enemies
-It has a scaling cooldown
-It is effective both offensively and defensively depending on the context of its use.
It's obviously meant to be a powerful escape, but it's also very powerful late-game as a dot/heal, and very powerful as a mid-game slow for ganks. It's also effectively a ghost, which makes it great for juking, but that's probably the lowest utility of the skill.
Historically, this ability has been fixed and nurfed a few times. It used to grant a tiny move speed increase while Vlad's character animation shifted into the pool, which was an unintended bug. The slow on the move speed has been nurfed by 10%, and the cooldown has been increased.
Regardless of the changes, this ability remains one of the best escapes in the game. A Vlad with flash, cleanse, Zhonya's, and Quicksilver Sash is ridiculously tough to kill.
E - Tides of Blood
Vladimir unleashes a torrent of blood dealing 60 / 90 / 120 / 150 / 180 (+45% of ability power) magic damage to nearby enemies.
Each cast gives him an Empowered stack (max 4), increasing his healing and regeneration by 8% each. Additionally, his next Tides of Blood deals 25% more damage and costs 50% more Health per stack.
Cooldown 8seconds
Cost 30 / 40 / 50 / 60 / 70 health
Range 300
Another amazing ability. In 5's, this increases your ability to farm exponentially. There's no max target number on this, which means if there's a creep-wave that's been building up for a long time, you can use one or two uses of this ability coupled with W (Sanguine Pool) to make hundreds of gold instantly. In Dominion, this ability allows you to hold a point without having to worry about a team of champions coming to assault you. Because of the AoE, it's very difficult for champions to juggle your turret while the other one attacks you. It keeps your turret as an effective weapon for you as the defender. I notice that E is a more effective ability early-game in dominion and have been considering altering my skill progression because of that fact and Q's (Transfusion's) slow ramp up.
Because this ability has no maximum number of targets and a flat health cost, in some situations it can generate health when coupled with Spell Vamp items. I always build at least one spell vamp item on Vlad because of this fact. The heal/damage stacking buff you get on this ability also stacks well with spell vamp.
This ability has never really been nurfed, and it's never needed to be. Because of the fact that this ability is so balanced, I think it may be the ultimate key to getting Vlad to a balanced and universally accepted champ.
R - Hemoplague
Vladimir infects the target area with a virulent plague. Affected enemies take 10 / 14 / 18% increased damage for 5 seconds.
After 5 seconds, infected enemies take 200 / 300 / 400 (+75% of ability power) magic damage.
Cooldown 120seconds
Cost 15percent of health
Range 700
Vlad's ult is and always has been great. It's a damage amplifier for your entire team, and it's an AoE. That alone makes it fantastic, even without the powerful delayed nuke. The demoralizing effect this ability has on an enemy team is astounding. When I land an ult on the majority of the team, I can see them scatter. The graphic, the sound, and everything about this ult makes it threatening. It's great versus Trynd, or any other character with spell/damage immunity.
Some people say that this ult is the only reason to play Vlad, but to me that is ludicrous. This ability is powerful, but the cooldown is fairly long and it DOES cost health to cast, unlike his Q. The damage amplification for your team makes this a great opener to fights, but I tend to drop it right after both teams have committed to the battle.
This ability is one of the main reasons you're able to stand your ground in a lane. Around level 6, some mid characters ramp up more quickly than Vlad and begin to try to bully him out of the lane. Dropping this while they are about to take a tower hit can be devastating when combined with your other abilities.
This ability also makes Vlad very viable in Dominion because of the bursty nature of the battles in that mode. Popping an extra damage buff on top of Poppy, Leblanc, Yi, Xin, Warwick, Trynd, or any number of other characters can spell doom for the enemy team. It also helps direct your team's focus if they are paying attention.
So, What Does Vlad Really Need Going Forward?
In my honest opinion, Vlad doesn't need much. Even in his current state, I do fine with him. I've always done fine with him. Because of the recent changes to Rylai's, Vlad is very effective at snaring enemies with the right amount of cooldown.
However, the recent consensus of the message boards and apparently Guinsoo is that Vlad needs work. I can understand these sentiments. I don't agree with them, but because of Vlad's intended role and previous heights of power, I could see how they have come up. What I believe Vlad needs depends very much on who's playing him. Some players might want more burst out of his Q (Transfusion) and might not care about a longer cooldown, whereas some players might want Q to be on a lower cooldown with less damage, and still other players might just want more health per use of Q. Because of the complex nature of Vlad's kit, it's hard to buff/nurf any piece of it without the entire kit feeling effected.
Vlad's main point of weakness is his early game, and it mostly stems from his cooldowns. His Q (Transfusion) isn't on a low enough cooldown to be effective until 9, but it's too important to rush to level because of it's last-hit utility, it's innate spell vamp, and it's range. His W (Sanguine Pool) is usually necessary to level second, because it's his escape, but it's also on a very long cooldown at early levels. If you pop your pool to avoid a skillshot and a jungler is hiding nearby, you're probably dead if you don't have flash. Because of the importance of these two abilities, his E (Tides of Blood) is usually left unlearned until 4th, and then usually left alone until W (Sanguine Pool) is at a comfortable cooldown at 3rd or 4th rank. I think it's a shame that Vlad's skillset pigeon holds him into a very cookie-cutter skill-up order.
Beyond his early game weakness, Vlad can easily be out-shone by other mages late-game. Brand is a good example of this. Why would I want a Vlad on my team, who, at max can have a slow if he chooses to build into it, when I could have Brand on my team who will be able to out-burst, out-CC, and out-damage Vlad? Sure, Vlad has a nifty escape and some cool survivability for himself, but how useful is that when Orianna could provide a ghost to the whole team that's also an AoE slow for the enemy team? Because of this, Vlad's last shining point is his ultimate, which keeps him unique, but it's a pretty big trade-off when placed next to the sheer damage that other mages in his class can generate with their ultimates.
So what can we do about these perceived issues? I've thought about how I'd tweak Vlad if given the chance for a very long time, and here's what I've come up with so far. Note that these ideas for tweaks aren't all meant to happen together, they are just ideas for changes based on my experience and understanding of Vlad. Vlad is too complex of a character to apply a large amount of changes to at once without damaging balance significantly.
Adjustments to Cooldown
Vlad's ability to pump out damage early game is very poor. Before 9, he can usually only pop his combo once before having to attempt to kite around the enemy while his Q (Transfusion) refreshes. His early game damage/healing is not high enough in my opinion to warrant as long of a cooldown as it has. I think on Q (Transfusion), the cooldown scaling should change from 8/7/6/5/4 to 6/5.5/5/4/3.
It's difficult to suggest a straight cooldown buff to the W (Sanguine Pool) because it's a very powerful escape. However, because of it's strength as an escape, it's rarely used offensively. I don't believe this is the intent of the design, because it has obvious offensive abilities. I think W (Sanguine Pool) should receive a bonus to it's cooldown one of two ways:
-If this ability does damage, make the damage done translate into increased cooldown to reward offensive play
-Link the pool to the buffs given from using E (Tides of Blood), and decrease the cooldown of pool by 5% - 8% per stack of Tides of Blood (maxing at 20% - 32% increased cooldown depending on the value assigned per stack). This would cause W (Sanguine Pool) to eat the buff stacks from E (Tides of Blood).
I think buffing the cooldown on W from using it offensively would make the ability less counter intuitive and more useful in varying situations. It would allow Vlad to utilize his only CC, which is a good CC move, but it's so risky to use as one currently.
Vlad's R (Hemoplague) also has a pretty long cooldown considering what it does. Brand's ult gets as low as 75 seconds without cooldown runes/items, and it does far more damage then Vlad's Hemoplague AND sets them up to potentially get stunned. Lux's Laser can get as low as 24 seconds, and can contribute to team-fights from great distances.
I think Vlad's Hemoplague should be buffed in a way that would reward skillful play. For every champion that Vlad kills or gets an assist on after Hemoplague, reduce the cooldown by 10 seconds.
Adjustments to Abilities
The heal from Q (Transfusion) is currently pretty lackluster unless you build spell vamp and stack your Tides of Blood pretty well. I think it would be better off if Vlad's Q always just healed him for a percentage of his health with a bonus % per 70 AP. This would allow for more variety in build options for Vlad, who is already pretty limited by the fact that he loses out on a lot of AP items by not having mana.
E (Tides of Blood) is a confusing skill to many new Vlad players. It's difficult to learn when to stack up the buff/debuff. Every cast makes this ability cost more to cast, but increases the vamp of your Q (Transfusion) and the heal from your W (Sanguine Pool). Do something more with this ability, because currently the buff is mediocre compared to the cost. I'll maybe heal 10-30 more HP off of my Q (Transfusion) endgame with 4 stacks. I really think there are valuable potential cooldown applications to this buff. It could work like Casseopeia's Deadly Cadence, but for cooldowns instead of mana.
Well, this wall of text is China Sized, and if you made it through the whole thing, you must really care about Vlad. I hope you've enjoyed my insights, and I'll be checking back in to respond to thoughts/criticisms.
TL : DR - Vlad doesn't really need work in my opinion, even though he is outshone by some other mages like Brand. If anything, he could use some increased CDR on his early Q (Transfusion), and some minor fixes to the confusing nature of his W (Sanguine Pool), but there's really nothing that glaringly wrong with Vlad. Over-nurfing or Over-buffing any piece of Vlad's kit has far reaching implications to the entire rest of his playstyle, and creative cooldown adjustments while keeping Vlad's damage numbers close to what they are now would provide Vlad a bit more of an edge versus his role's current competition.
Very well written, I am proud to say i read them all
Only part i may disagree with you is the % healing of transfusion, because it will probably cause the following problems:
-Early game healing is too low
-Mid game healing is ok
-Late game healing will be magnificent
It still depends on the numbers but this is what i think will come up and the qq will start again
Obviously other mages can out-range Vlad, but they are typically very squishy. Vlad's benefit from his passive is that he doesn't have to be too afraid of wading into battle, at least if there's support from his team or a turret nearby.
On Dominion, this is useful because he can walk up to a tower that's getting assaulted, walk right up to the people assaulting it, pop his E, and both of them are off of it, and any creeps that are assisting the assault are damaged.
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Lost Girl: Season 2, Episode 15Table for Fae (29 Jan. 2012) 7.6
Bo and her new Dark Fae boyfriend work together to track down the culprit behind the murder of a backpacker. Kenzi and Bo plan a double date, but humans and Fae don't always play nice. Director:David Greene |
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Have you had enough of all the neglect and abuse of ME/CFS patients? Gabby Klein says now is the time for a National PR Campaign for ME/CFS to impress a change. Join the Patient Revolution to restore power to ME patients ...
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Why is Australia so behind the rest of the world in tests and immune modulators??
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- Tania Ganguli of the Orlando Sentinel: "The Orlando Magic are well aware of how important this weekend. Center Marcin Gortat called it the most important weekend of the season. After practice on Friday, Magic coach Stan Van Gundy acknowledged that the season would be judged based on how the team performed in the playoffs. He said the expectations surrounding the Magic are a good thing and right where the franchise wants to be."
- John Denton of OrlandoMagic.com: "For two days since the Orlando Magic plummeted into a shocking 0-2 hole, Rashard Lewis has had plenty on his mind. He's thought repeatedly about ways to get himself more involved in the offense, he's steamed over the trash talk from the Boston Celtics and he's listened to the noise about how the Magic are done. All of it, combined with the frustration of losing the first two games of the Eastern Conference Finals, has raised the dander of the mild-mannered, soft-spoken Lewis. He vowed on Thursday that the Magic might be overlooked now and little expected of them, but by Saturday's Game 3 people will see there is still plenty of life left in this team."
- Dan Savage of OrlandoMagic.com thinks there's still hope for the Orlando Magic in the 2010 NBA Eastern Conference Finals: "With each step taking me closer to the Magic's locker room, I feared I'd see a room with heads held low and the look of utter defeat. But upon my arrival, I witnessed the near antithesis of my worries. The team's facial expressions and body language still reflected determination and a complete belief that they could turn this series around. And that's the moment that initiated my metamorphosis from a sullen disbeliever to an all-biases-aside-writer who sincerely thinks that Orlando's Finals run is far from over. "
- Rob Mahoney of ProBasketballTalk responds to Matt Barnes' comments about Paul Pierce being a flopper: "Paul Pierce is a fantastic player, but the infuriating thing about him is that he stands (or falls?) amongst the most egregious floppers. It's one thing for Paul to exaggerate a bump on the way to the rim, but the way he collapses on the floor after minimal incidental contact or pretends to be hit in the head while shooting seems like it should be beneath him. He's honestly too good of a player to be compensating like that. […] Barnes' quote applies more to a singular incident of Pierce's flopping than a general trend, but his point stands. However, that doesn't mean I'm here on a holy crusade to rid the world of the flopping abomination. That's the problem, actually. No matter how much we rant and rave, there isn't a convenient solution to get rid of this kind of play. Pierce will continue to go on rewarded for what he does, and there's really not much the NBA can do about it."
- Ben Q. Rock of Orlando Pinstriped Post: "A lot of things need to happen for the Magic to make this series interesting again. Three-point shooting is just one aspect. But it's an important aspect. Getting to the foul line more–[Dwight] Howard and [J.J.] Redick are the only two players do to it consistently–can offset the lack of three-point chances, but it's clear that the Magic need to rediscover what they did against the Celtics in the regular season. In those 4 games, Orlando got 27 of its 78 three-pointers from the corners, or 34.6%. Before the Conference Finals, the Celtics adjusted. Now, the Magic need to counter. Otherwise, they'll be vacationing sooner rather than later."
- Mickael Pietrus speaks!
- Assistant coach Patrick Ewing could play some basketball in his heyday.
- Austin Burton of Dime Magazine: "I think Vince Carter can shake his reputation as a crunch-time choker and overall soft player. All he has to do is play the game of his life tomorrow."
- The top 10 players of the 2010 NBA Playoffs, featuring Jameer Nelson and Dwight Howard … in that order.
- Bradford Doolittle of Basketball Prospectus: "It's apparent that the Celtics are not going to allow Rashard Lewis to become a big factor in this series. If that trend seems to be continuing in Game 3, I'd like to see Stan Van Gundy give more time to Marcin Gortat, who has been a spark whenever he's stepped on the floor in the first two games. I don't always love a Gortat/Dwight Howard pairing on the Magic frontline, but I do like it against the Celtics' starting unit. Orlando can dominate the glass and as long as Kevin Garnett is struggling with his jump shot, Gortat should be able to contend with him on the defensive end. So far, it's felt like Van Gundy has struggled to adjust to what Doc Rivers (or Tom Thibodeau, as the case may be) has thrown at him defensively. Going really big may force Doc to make some unwanted adjustments."
« Marcin Gortat and Dwight Howard Training Together
Media Log: 2010 NBA Draft Combine Media Availability Day 2 »
May 21


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Straight after Friday Night Shuffle, we'll be replaying two of the best Summer mixes from British tastemaker Oneman and American duo Soul Clap!
updated 27/01/2015
This Saturday night at 9PM Nina Las Vegas has heaps of new club tunes for you!
Straight after her hour, you'll hear exclusive mixes from three touring acts including DJ EZ, Gent & Jawns and UK based Mele!
updated 27/01/2015
Do you like dancing? So do we. Lets dance together with some of the best dance DJ's locally and around the world. Yay! Dancing.


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Written on: 15/10/2001 by fatmandies. (1 review written)
Good Points
it has new buildings and has lots of new units.
Bad Points
the gdi have less powerful units then the nod.
General Comments
hmmmm - 8 out of ten.
As rated by real users
" Poor Services " Read More
" Docplay is a scam " Read More
" The good points are that you get 2 weapons for free when you start.... " Read More
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" Three Awesome RPG's " Read More
Written by jakewhit


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Eric Clapton With JJ Cale – Call Me The Breeze
Late Late Nite FDL: Clapton And Cale |
By: Eureka Springs Monday June 30, 2008 10:00 pm |
Sometimes an Acorn is Just a Nut. |
By: watertiger Monday June 30, 2008 7:57 pm |
Inflammatory alarmist puffery isn't just a hobby; it's a way of life!
This Is Just Stupid |
By: Phoenix Woman Monday June 30, 2008 6:30 pm |
The Bush Junta has been pressuring British banks to stop having financial dealings with Cuba — even though the British government isn't a party to the asinine embargo. That's stupid. But here's what's even stupider: Bush wants to invade Iran.
Red State Road Trip: The War on Our Streets |
By: GRITtv with Laura Flanders Monday June 30, 2008 5:45 pm |
Since 2005 writer, director, and guerilla filmmaker Chris Hume has been crisscrossing the United States on what he calls a "red state road trip." It's been a long and sometimes strange trip and here in episode eight, season 2 Hume looks at just how easy it is to buy a gun.
And I Don't Need No Hook For This Shit: How To Read Sy Hersh |
By: Spencer Ackerman Monday June 30, 2008 4:05 pm |
As a rule, I don't criticize Sy Hersh pieces. Reporters do not have the right to fuck with Hersh until they've run through a Georgia barracks trying to find Calley or learned about an entirely secret war that Congress never dreamed of or published excerpts of the Taguba report. You do this, you can criticize.
Taking the Presidential Debates on Grand Tour |
By: looseheadprop Monday June 30, 2008 2:30 pm |
During the Gilded Age, nouveau riche Americans trying to acquire a veneer of sophistication and polish would embark upon a version of the "Grand Tour" of Europe. They would develop a smattering of foreign language skills, visit the great cities of Europe, hire tutors to teach them about art and architecture–and sometimes deportment–and they would go to museums.
The F Word: So Much For Alternative Energy . . . |
By: Laura Flanders Monday June 30, 2008 1:45 pm |
So much for the Government's much touted commitment to alternative energy…
The New York Times reports the Bush administration has placed a nearly two year moratorium on the construction of new solar energy projects on public land. While the amount of oil drilling and gas drilling on public land has reached a new high…
Wes Clark Walks Into McCain's Giant Wood Chipper |
By: Jane Hamsher Monday June 30, 2008 12:06 pm |
I understand what Wes Clarke was trying to say about John McCain when he said that getting shot out of a plane doesn't qualify as foreign policy experience. I can also understand that every strategist on the Obama campaign must've had apoplexy when they heard the comment. It's exactly what the McCain campaign has been waiting for — the ability to turn McCain into Petraeus. Small wonder McCain won't accept Obama's denunciation. The whole "Betrayus" episode provides the perfect blueprint for how to turn the press corps into a bunch of pearl-clutching, histrionic nitwits.
Wingnuts: Only Bush And Rove Are Allowed To Question McCain's Military Record |
By: Blue Texan Monday June 30, 2008 10:30 am |
There's quite a bit of wingnut pearl-clutching over Wes Clark's rather mild comment over the weekend about McSame's military service. In their two minutes of hate, they seem to have conveniently forgotten what Karl Rove did to McCain in 2000 to get The Great Leader elected.
… Bush surrogates (several later involved in the Kerry swiftboating effort) skillfully turned McCain's service record against him (thereby deflecting questions about Bush's own service
Home Today, Homeless Tomorrow? |
By: Christy Hardin Smith Monday June 30, 2008 9:32 am |
Welcome to the US of A. Not something out of Dickens or the Dustbowl and the Jodes, but right now, right here: A "safe parking" program in Santa Barbara, CA:With numbers rising, New Beginnings, a homeless agency in Santa Barbara, California, has launched a Safe Parking Programme, aiming to provide a refuge of sorts for those who have nowhere to go other than their vehicle….


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Credits & Info
- Uploaded
- Jan 9, 2008 | 8:13 AM EST
If you liked this, check these out!
That's My Fulp 23 by MaddFlash
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Plenty more like this here!
That's My Fulp We don't actually act like this but it's funny to watch.
Author Comments
That's My Fulp Season 3 Episode 21: No Country for Old Fulp!
Rated 4.5 / 5 stars
Well i probably don't understand it completely considering i never watched that movie "No country for old men" but that doesn't take away from the fact that this was still funny as hell especially with Wade at the end.
Rated 4 / 5 stars
Oh god what is the name of that song - I heard it on TBL and I've wanted it - PLEASE?! oh and yeah the flash was pro.
Rated 3 / 5 stars
I am sorry but.
This series jumped the gun at the start of the 2nd season. You have been trying to put all this special crap in and look what happened! The scores are a lot lower because people don't like it anymore. I don't like the new seasons very much but the old ones were gold.


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Shoulder Pain / Shoulder Surgery Manhattan, NYC
Shoulder pain for many is a common occurrence that can greatly disturb one's comfort, especially for athletes or those who are active daily. Columbia Center for Shoulder, Elbow and Sports Medicine is a practice located in the upper west side of Manhattan, NYC easily accessible from Northern New Jersey, that provides the highest standard of care for people and athletes allowing them to recover from conditions such as shoulder pain. Each patient receives the highest level of medical care for shoulder conditions that may require complex shoulder surgery. If you are suffering and are in need of orthopaedic care, Call Columbia Center for Shoulder, Elbow and Sports Medicine today and schedule an appointment.
The combined experience of the professionals at Columbia Center for Shoulder, Elbow and Sports Medicine gives any of the patient's access to the latest and best in joint rehabilitation surgery. The shoulder is a very complex joint with many different parts working together to allow normal function. If any of these parts should weaken or become unstable, shoulder pain is a result. A wide variety of conditions can come about and many may be treated with the latest non-invasive, rehabilitative methods. Shoulder surgery is a procedure that is not always necessary for certain injuries. With the expertise at Center for Shoulder, Elbow & Sports Medicine, each patient is sure to receive the proper treatment for their injury or pain. If shoulder surgery is necessary, than on staff is some of the most skilled surgeons that work with you to achieve the best recovery possible. Doctors at Columbia Center for Shoulder, Elbow and Sports Medicine have served on professional teams such as the New York Yankees as well as prestigious collegiate teams providing their professional help and each patient that comes in is sure to be treated in the same manner.
The Doctors at Columbia Center for Shoulder, Elbow and Sports Medicine are experts in administering orthopedic solutions in:
- Arthroscopic Shoulder Surgery
- General Orthopaedics
- Sports Medicine
- Joint Replacement
- Shoulder, Elbow, and Arm surgery
If you have been suffering with shoulder pain, or are considering shoulder surgery, it would be best to visit a group of doctors whose treatment you can be sure of. Columbia Center for Shoulder, Elbow and Sports Medicine located in Manhattan, NYC is accessible from all parts of New York as well as northern New Jersey. Call today to schedule an appointment.
- ACL Injuries with NFL Players | Orthopedics
- Elderly Individuals Can Lower Their Risk of Type 2 Diabetes by Taking Short Walks
- Expert Commentary: Mary S. Burns, PhD 12/2/2009
- For Common Diseases, Exercise 'as Effective as Drugs'
- For Longevity Being Fit Is Paramount, Regardless of Weight
- One Simple Solution to Neck Pain: Good Posture
- Reduce Heart Failure Risk by Getting Fit in Middle Age
- Routine Exercise Raises Life Expectancy Even If Overweight
- Stay Youthful, Keep Running
- Want to Be Healthy? Then Work Up a Sweat


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We came to Knonau because we were invited by a workmate of mine to a house warming party.
Walking to her place we were pleasantly surprised to see the historical buildings in the village center.
- Pros:Some historical buildings
- In a nutshell:A pleasant place to live in
Reviews (6)
a lot of people put a pole with an appropriate sign in their garden or if they don't have a garden you will find it... more travel advice
As Knonau is situated in a more rural area, you may consider take a hike in the area. At the railway station you will... more travel advice
Another landmark in Knonau is the protestant church. The church was consegrated in 1519 to the holy Gertrud and... more travel advice
You may only view the good looking castle and it various buildings from outside as it is privately owned by some German... more travel advice
Been to Knonau?
Share your travels with the world!
Comments (9)
Nice that you were invited by a workmate of yours to a house warming party. I assume she is not the German person who lives in the castle, LOL.
I like the look of the buildings in your photos. It all looks so pretty and just like I imagine Switzerland!
Small wild location :) I am amazed how much infrastructure you have for hiking! :)
Knonau looks like a very pleasant village! Must say that a hike to a Rhodondendron Park sounds to be a nice thing to do.
Picturesque small town! Aren't the Germans in Switzerland a nuisance, buying everything? ;-)
I would also visit the Rhododendron park taking a hike in this area...
seems to be nice place for a little trip
There are some really great wooden and halftimbered houses in Knonau !
Lovely little page with brilliant photos of this little Swiss gem.
Knonau Travel Guide
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Reviews for Hotel Utama
Address: Calle Michell Perez esq., Copacabana, BoliviaRooms from: US$ 26.00
Ratings Explained
(Hostelworld.com and Affiliate sites)The following reviews were submitted by customers who booked through our sister site, Hostelworld.com, in the last 12 months.
The ratings in the rating box are based on all-time feedback for the property and are the opinions of the customers who submitted them; they do not express the opinions of Hostelworld.com or our affiliate sites.
Overall Rating (37 Ratings)
Customer Reviews for Hotel Utama
vraffelseder1023, from Austria ~ 3rd Apr 2014
willboarding4325, from England ~ 9th Apr 2014
normflemington6717, from Canada ~ 30th Mar 2014
ulstrup1991811, from Denmark ~ 17th Mar 2014
kategartner7323, from England ~ 3rd Mar 2014
jadebruckner5008, from Australia ~ 6th Mar 2014
margaretroberts404, from England ~ 4th Mar 2014
jwong22099516, from England ~ 25th Feb 2014
helencopsey5532, from New Zealand ~ 30th Jan 2014
diptiravi5091, from USA ~ 17th Feb 2014


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Demo Derby: Official PlayStation Magazine: Issue 58
Become Premium to Watch
The chaos and fun of Saints Row is fully intact in the underworld, but a new setting can only go so far.
Dimensions recaptures enough of Geometry Wars' thrills to stand as the best new dual-joystick shooter in quite a while.
The little mushroom man finally gets his name on the marquee, and the result is a charming, unique, and puzzle-heavy adventure.
Company »
One of Hisao's classmates at Yamaku.
Head nurse as Yamaku.
Librarian at Yamaku.
A classmate of Hisao's at his old school, and indirect cause of his heart attack.
Hisao's homeroom and science teacher.
Mother of Emi Ibarazaki.
Kenji Setou is a supporting character in the visual novel Katawa Shoujo. He lives in the same dorm as the main character Hisao Nakai.
Akira Satou is one of many characters in the visual novel Katawa Shoujo. She's a successful business woman and is the sister of Lilly Satou whom is one of five love interests in the game.
Misha is the translator and friend of Shizune Hakamichi. Having spent so much time with Shizune she tends to forgot to control her volume, as cheerful as it may be.
Even though Shizune is deaf and a mute, she is a strong willed and competitive person that is also the student council president. She communicates with everyone with her friend and translator Misha.
Rin is a character and potential love interest in the visual novel/dating game Kawata Shoujo.
The president of Class 3-2, Lilly has been blind since birth. She is a elegant speaker and caring person, being the only friend of Hanako.
An extremely shy girl, half of her face was burned in a fire that took her parents' life. Although shy, she does find loyalty in another person who she seems to only trust.
Although she lost both of her legs below the knee, Emi is energetic and cheery as ever. Emi helps Hisao get into shape and is a possible love interest of his.
Hisao is the main character of Katawa Shoujo. Hisao suffers from Heart Arrhythmia and has to attend Yamaku High School in order to have people around to watch his condition.
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'The fighting could have been over by now if we would use the same tactics our enemies use'
July 18. Just came out of the secure room. The longest siren since the beginning. Three interceptions of the Iron Dome above us. Thinking of the absurdity of this round of violence. We started the ground offensive for humanitarian reasons. Yes, it sounds crazy but hear me out.
We have the ability to flatten the Gaza Strip from the air (remember what happened to Dresden in the Second World War?), but we do not do it because it is morally wrong. Thousand of uninvolved civilians can get killed, after all they are serving against their will as human shields. Since we cannot and will not do it from the air, we are now putting the lives of our soldiers on the line in order to save the lives of uninvolved Palestinians by searching for the tunnels on the ground and engaging the Az A din El Kassam terrorists on the ground, while they keep on targeting our cities with their missiles.


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Publications (56)126.54 Total impact
- Journal of endocrinological investigation 07/2014; 30(7):624-5. · 1.65 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. Results: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. Conclusions: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.Asian Pacific journal of cancer prevention: APJCP 05/2013; 14(5):2801-2803. · 1.50 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Background: Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic and gastric cancer. However, it is unclear whether there is such an association with colorectal cancer (CRC). In this study, possible relationships between ABO blood groups and Rh factor and KRAS status in patients with CRC were investigated. Materials and Methods: In 1,620 patients with CRC, blood group and Rh factor were examined and compared with the control group of 3,022,883 healthy volunteer blood donors of the Turkish Red Crescent between 2004 and 2011. The relationship of blood groups with wild type K-ras status was also evaluated. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (45% A, 7.2% AB, 16.4% B, 31.4% O, and 87.2% Rh+) and controls (42.2% A, 7.6% AB, 16.3% B, 33.9% O, and 87.7% Rh+) (p=0.099). However, there were statistically significant difference between patients and controls with respect to O vs. non O blood group (p=0.033) and marginally significant difference for A vs. non-A blood group (p=0.052). Among patients, the median age was 62 (range 17-97), 58.1% were male. There were no statistically significant differences respect to sex and K-ras status. Conclusion: In present study, the ABO/Rh blood groups were statistically significantly associated with the risk of CRC. There were no relationship between K-ras status and ABO blood group and Rh factor. However further studies with larger numbers of patients are needed to establish the role of blood groups and to define the mechanisms by which ABO blood type affect CRC.Asian Pacific journal of cancer prevention: APJCP 12/2012; 13(12):6097-100. · 1.50 Impact Factor -
Article: Relationship between antimetabolite toxicity and pharmacogenetics in Turkish cancer patients.
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ABSTRACT: Antimetabolites may cause severe toxicity and even toxic death in cancer patients. Our aim was to evaluate the relationship between antimetabolite toxicity and pharmacogenetics in patients with severe clinical toxicity or alanine transaminase (ALT) elevation after fluorouracil (5FU), capecitabine or methotrexate administration. Cancer patients with severe antimetabolite toxicity were evaluated for methylenetetrahydrofolate reductase (MTHFR) gene C667T, thymidilate synthase (TS) gene 5' UTR variable number of tandem repeats (VNTR), dihydroprymidine dehydrogenase (DPYD) gene IVS14+1G/A, Xeroderma pigmentosum (XPD) gene Lys751Gln and X-ray repair cross-complementing group 1 (XRCC1) gene Arg399Gln polymorphisms. Eighteen patients were enrolled, with a male/female ratio of 0.8. They had osteosarcoma in methotrexate group (n=7), gastrointestinal malignancies in 5FU group (n=9) and breast cancer in the capecitabine group (n=2). Mucositis and dermatitis occurred in all groups, together with ALT elevation in the methotrexate group and 2 toxic deaths were encountered. DPYD, TS, MTHFR, XPD and XRCC1 gene polymorphism rare allele frequencies were observed to be higher than in the general population. Pharmacogenetics might contribute to tailored therapy.Asian Pacific journal of cancer prevention: APJCP 01/2012; 13(4):1553-6. · 1.50 Impact Factor - European Journal of Cancer 09/2011; 47. · 4.82 Impact Factor
- European Journal of Cancer 09/2011; 47. · 4.82 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: This study was designed to assess the tolerability of chronomodulated infusion chemotherapy, individualized by the rhythm of peripheral blood cells. Twenty patients with metastatic gastric cancer were randomized to chronotherapy or day-time arms of 5-fluorouracil (FU) (600 mg/m2, 8 h inf.d1–5) and folinic acid (FA) (20 mg/m2, iv, d1–5) in the first cycle and crossed-over to the other arm in the following cycles. Ten of 18 evaluable patients were assigned to chronotherapy arm and eight to day-time in the first cycle. Although there was no significant difference between two arms on enrollment, chronotherapy arm yielded an improvement of 45% of QLQ-C30 scores (p = 0.021) and the day-time arm had 11% improvement (p = 0.575). After the crossing-over, chronotherapy arm, again, had a significant improvement in QLQ-C30 scores, compared to the day-time arm (14% vs. −18%, p = 0.001, respectively). Mucositis/diarrhea was significantly higher in the day-time arm compared to chronotherapy arm (p = 0.015). In conclusion, chronomodulated infusion of 5-FU might improve the quality of life.Biological Rhythm Research 11/2010; 35(4):259-268. · 1.22 Impact Factor -
Article: Fifty-one Kaposi sarcoma patients.
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ABSTRACT: Kaposi sarcoma (KS) is a mesenchymal tumor originating from lymphatic endothelial cells. Immunosuppressive patients have higher risk for KS. HHV-8 has a role in immunopathogenesis of KS. Aim Evaluation of demographical properties with tumor characteristics and treatment modalities of KS. Histopathologically documented KS patients were evaluated retrospectively. Anti-HIV seroprevalence was also evaluated with patient and tumor characteristics besides treatment regimens. Fifty-one patients were included between September 1998 and February 2009. Male/female ratio was 3.25 (39/12). Median age was 68 (31-94). Lower extremity was the most common site whereas excisional biopsy was the most common diagnostic procedure. Smoking rate was 42.8%. Twenty percent had family history for cancer. Anti- HIV seropositivity rate was 1.9%. Thirty eight percent had local monotherapy, and radiotherapy was most common (26%). Multidisciplinary approach rate was 44%. Most of them had surgery and radiotherapy combination. Two-third of the patients had radiotherapy alone or with other modalities. Rates were as 12% for chemotherapy and 6% for interferon. Vincristine-bleomycin-doxorubicin combination was the most preferred regimen (60%). Male patients in the sixth decade seem to have higher risk for KS. Smoking rate was almost as high. Local therapy might be sufficient in most of the patients. However, we may also consider systemic chemotherapy for selected patients, including vincristine, bleomycin and doxorubicin.Clinical and Translational Oncology 09/2010; 12(9):629-33. · 1.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The aim of the study was to evaluate the relationship among leucocytosis, thrombocytosis and serum vascular endothelial growth factor (VEGF) levels and their prognostic value in patients with NSCLC. Fifty-five patients with histopathological and/or cytopathological diagnosed NSCLC were enrolled into the study. The patients were grouped as patients with leuco-cytosis (>10.000/mm 3) and/or thrombocytosis (>400.000/mm 3) (group 1), and others with none of them as a control group (group 2). Serum VEGF levels were measured by ELISA. Group 1 had three subgroups: patients with leucocytosis (group 1a), patients with thrombocytosis (group 1b) and patients with both of them (group 1c). Survival of the patients were analysed by Kaplan-Meier method. There was no survival difference between group 1 and 2, although there was a trend in favour of control group. The patients with higher levels of serum VEGF had a shorter survival than others who had lower lev-els, when the mean VEGF level of control group (206 pg/ml) was defined as cut-off value in group 1. The patients with leu-cocytosis and thrombocytosis had significantly higher VEGF levels when compared with control group (p= 0.022). No sur-vival difference was observed for groups 1a, 1b and 1c when compared with control group. In conclusion, serum VEGF lev-els were significantly higher in patients who had leucocytosis and/or thrombocytosis although leucocytosis and/or throm-bocytosis could not have been shown as a prognostic factor in patients with NSCLC. The association between serum VEGF and leucocytosis/thrombocytosis could not have been concluded as a cause or result.International Journal of Hematology and Oncology. 01/2010; 20(1):14. - [Show abstract] [Hide abstract]
ABSTRACT: In aggressive non-Hodgkin lymphoma (NHL), CHOP (cyclophosphamide, vincristine, doxorubicin, prednisolone) regimen has been standard for decades, and rituximab has increased response rates and survival in CD20 positive patients, recently. The aim of this prospective trial was to evaluate the long-term efficacy and toxicity of MINE as a consolidation treatment in aggressive NHL patients who had achieved CR or unproven CR after six cycles of CHOP in the first line setting. The primary end-point was disease-free-survival (DFS). Thirty-eight patients were enrolled between February 1992 and May 2000. All of the patients received two cycles of MINE (mesna 1.3 g/m(2), ifosfamide 1.3 g/m(2), etoposide 65 mg/m(2) on days 1-3, and mitoxantrone 12 mg/m(2) on day 1, every 3 weeks) following response to CHOP. Initial bulky disease sites were also applied radiotherapy. Male/female ratio was 1.53(23/15). Median age was 49(30-73). Most of the patients had advanced stage (84.2% for stage >3) and high IPI score (79% for IPI score >2). Sixty percent had diffuse large cell histology. Median follow-up time was 118 months (9-195). Actual mean dose intensity was 88%. There were seven febrile neutropenia episodes. Two patients had grade two neuropathy, one had grade three mucositis and another one had non-neutropenic pneumonia. There was no early toxic death. No serious late toxicity was observed during long-term follow-up. Five- and 10-year DFS rates were both 65.3%. DFS rate in the patients with more than two poor prognostic factors according to IPI score is remarkably high (88%). Five- and 10-year OS was 62.5 and 59%, respectively. MINE regimen seems to be effective as a consolidation regimen, especially, in intermediate/high risk patients and has low early and late toxicities, and it warrants to be evaluated in phase III randomised trials with rituximab in CD20 positive aggressive NHL patients.Medical Oncology 09/2009; 27(3):942-5. · 2.06 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Telomerase is a specialized cellular reverse transcriptase that adds telomeric repeats (TTAGGG) at the ends of each chromosome. Nearly the complete spectrum of human cancers has been shown to be telomerase positive. The understanding of the telomerase regulation in concert with other genetic alterations in the process of malignant transformation of human cells has important clinical and practical implications. Regulation of telomerase activity (TA) is highly complex, and both putative positive and negative regulators have been reported. However, the mechanisms involved in telomerase regulation are not fully established. Identification of additional telomerase components and associated proteins will certainly contribute to further investigations of the effect of telomerase in telomere elongation, telomere length maintenance, oncogenesis, and functionally new, unidentified cellular functions. In this study our aim was to determine the chromosomal localizations of putative unidentified telomerase activator(s) and/or repressor(s) by high resolution-comparative genomic hybridization (HR-CGH) in highly telomerase expressing gastric tumor samples. For this purpose TAs and genomic imbalances were identified in the same tumor samples and relation between these was evaluated. Genomic changes affecting telomerase activity in 50 gastric tumor samples were investigated by HR-CGH. We have found that genomic imbalances including 1q+, 8p+, 8q+, 10q+, 17p-, and 20p+ are associated with the higher telomerase activity. Our results suggest that 1q24, 8p21-p11.2, 8q21.1-q23, 10q21-qter and 20pter-p11.2 may contain putative telomerase activator(s), whereas the 17p12 region may harbor candidate telomerase suppressor(s).Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 02/2009; 17(10):455-62. · 0.92 Impact Factor - Cytopathology 02/2008; 20(2):117-20. · 1.47 Impact Factor
Article: Prognostic Significance of Serum Matrix Metalloproteinase 9 (MMP-9) Levels in Patients with Sarcomas
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ABSTRACT: Sarcomas are heterogeneous groups of tumors that are seen rarely. Although great efforts have been made to identify prognostic factors apart from grade, histology and tumor size, they're not so obvious yet. In this study, the prognos-tic role of serum matrix metalloproteinase (MMP)-9 levels in patients with sarcoma was evaluated. Eighty-eight patients with a diagnosis of sarcoma were included in the study. Additionally in 14 patients with osteosar-coma, serum MMP-9 levels were analyzed twice, one in preoperative period during neoadjuvant chemotherapy and one in postoperative period. Sixteen healthy volunteers composed the control group. Serum MMP-9 levels have been evaluated quantitively by ELISA method. Serum MMP-9 levels were higher significantly compared to control group (p<0.005). Patients with metastatic disease have higher serum MMP-9 levels compared to the non-metastatic ones which were statistically non-significant (p: 0.9). Similarly, no difference in serum MMP-9 levels was observed between patients with intermediate-high grade tumors and with low grade tumors. Moreover, statistically significant decrease in serum MMP-9 levels was observed in patients in postoperative period compared to preoperative period (p: 0.016). Although this study was performed in small number and heterogeneous group of patients, the difference in serum MMP-9 levels between sarcoma patients and control group, especially in the presence of measurable lesions and in postoperative period of the same patients, suggests that serum MMP-9 levels may be used as a tumor marker in patients with sarcoma. ÖZET Sarkomlu Hastalarda Serum Matriks Metalloproteinaz-9 Düzeyinin Prognostik Değeri Sarkomlar oldukça nadir olarak gözlenen heterojen bir tümör grubudur. Tüm çabalara karşın tümör histolojisi, greydi ve tumor boyutu dışında bir prognostik faktör tayin edilememiştir. Bu çalışmada sarkomlu hastalarda serum matriks metalloproteinaz-9 (MMP-9) düzeyinin prognostik değeri araştırıldı.01/2008; - [Show abstract] [Hide abstract]
ABSTRACT: There are few reports on use of symptomatic benefits as an alternative or adjunctive for the assessment of objective response in chemotherapy of the advanced cancer. This study is performed to assess the symptomatic benefits (the clinical benefit response), in addition to the efficacy and toxicity of cisplatin plus infusional 5-fluorouracil (5-FU) combination as second-line therapy in patients with advanced gastric cancer. Fifty-eight advanced gastric cancer patients with previous chemotherapy were enrolled into the study. Cisplatin 20 mg/m2 was given for 5 days, and 5-FU was given 1000 mg/m2 as 20 h continuous infusion for 5 days, repeated every 28 days. The overall objective response rate was 11.3%, and overall tumour control rate was 33.9%. The clinical benefit response, in terms of weight gain, reduction in analgesic consumption and the improvement in performance status observed in 12 patients [six patients with partial response (PR) and six patients with stable disease (SD)] (22.6%), while the rates of the clinical benefit response in patients with PR and with SD were 100% and 50% respectively. Cisplatin plus infusional 5-FU combination seems to improve disease-related symptoms (clinical benefit response) of patients with advanced gastric cancer, even in patients without objective response.European Journal of Cancer Care 12/2007; 17(1):26 - 32. · 1.31 Impact Factor - EJC Supplements 09/2007; 5(4):416-416. · 2.71 Impact Factor
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ABSTRACT: In this non-randomized study we aimed to assess the efficacy of the addition of low molecular weight heparin (LMWH) to gemcitabine (GEM) plus cisplatinum (CDDP) combination chemotherapy on survival by prevention of thromboembolic complications in patients with advanced pancreatic cancer (APC). Between November 1999 and February 2004, 69 consecutive patients with APC were treated with GEM (800 mg/m2, day 1, day 8) plus CDDP (35 mg/m2, day 1, day 8) every 21 days +/-LMWH (nadroparine calcium, 2,850 IU/day until disease progression). Ten out of 35 patients in LMWH group and 10 out of 34 patients in chemotherapy alone group had primary inoperable locally advanced disease and the rest of the patients had metastatic disease. Total response rate was 58.8% (11.7% CR) for the patients treated with LMWH and 12.1% for those treated without LMWH (P = 0.0001). LMWH group had a better median time to progression (TTP) and survival when compared to control group (7.3 vs. 4.0 months, P = 0.0001; 13.0 vs. 5.5 months, P = 0.0001). The toxicity was similar and acceptable in both groups. Addition of LMWH to GEM plus CDDP combination significantly improved the response and survival in patients with APC and the current schedule deserves to be tested in phase III trials.Journal of Surgical Oncology 06/2007; 95(6):507-12. · 2.84 Impact Factor - Southern Medical Journal 03/2007; 100(3):334-5. · 1.12 Impact Factor
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ABSTRACT: Malignant mesothelioma is a rare but notoriously chemoresistant tumor. An impressive activity of gemcitabine and cisplatin combination in malignant mesothelioma has been shown. However, the hematological toxicity and nephrotoxicity related to this regimen affect the patient's life negatively. The aim of this study is to investigate the efficacy and toxicity of divided dose of cisplatin combined with gemcitabine in chemo-naïve patients with malignant mesothelioma. Twenty-six eligible patients with malignant mesothelioma were enrolled onto the study. Cisplatin 35 mg/m(2) and gemcitabine 800 mg/m(2) were administered on days 1 and 8 as intravenous infusion in a 3-week cycle, up to maximum 6 cycles. Response and toxicity evaluations were performed in 26 patients. Male-female ratio was 11/15 with a mean age of 50.5 years (37-70). Locations of tumor were pleura in 16 patients, and peritoneum in 10 patients. All patients had epitheloid subtype of malignant mesothelioma. The partial response and stable disease were observed in 6 patients (23.1%) and in 13 patients (50%), respectively, with an overall tumor control rate of 73.1%. Seven patients (26.9%) had progressive disease. Median time to disease progression and survival were 4 and 19.5 months, respectively. Grade 3 nausea and vomiting were observed in one patient (3.8%), grade 4 neutropenia developed in one patient (3.8%) and grades 3-4 thrombocytopenia and nephrotoxicity did not develop. There was no treatment related death. Divided dose of cisplatin combined with gemcitabine, at the current dosage and schedule, appears to be an active regimen in chemotherapy-naïve patients with malignant mesothelioma, and well-tolerated.Lung Cancer 10/2006; 53(3):367-74. · 3.74 Impact Factor - Annals of Oncology 01/2006; 16(12):1981. · 6.58 Impact Factor
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ABSTRACT: Venous thromboembolism (VTE) is a well-recognized problem in malignancy. Patients with cancer who have VTE have a worse prognosis than other patients with cancer. Hypercoagulability in patients with cancer is related to malignancy itself and its treatment. These patients have multiple risk factors for thromboembolism, such as being immobilized, having central venous catheters, and receiving chemoradiation therapy. Cancer procoagulant, tissue factor, factor VIII, and thrombin have important roles in causing cancer-associated thromboembolism. Tumors require neovascularization for delivering oxygen and other nutrients. Therefore, angiogenesis facilitates tumor growth, invasion, and metastasis. New blood vessels formed by angiogenesis are thrombogenic. Hypercoagulability and tumor growth are closely related. Vascular endothelial growth factor (VEGF) is a proangiogenic factor that may also cause VTE in patients with cancer. The relationship between cancer, angiogenesis, VEGF, and thrombosis is reviewed herein. Studies are ongoing to enhance our understanding of this complex interaction.Supportive Cancer Therapy 10/2005; 3(1):28-34.
Publication Stats
304 | Citations | |
126.54 | Total Impact Points | |
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Ankara University
- • Department of Medical Oncology
- • Department of Internal Medicine
Ankara, Ankara, Turkey
Dicle University
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Amida, Diyarbakır, Turkey
Ibn Sina Hospital Dhanmondi
Baghdād, Mayorality of Baghdad, Iraq


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By Rebecca Silverstein
Is she or isn't she? That's the question I was left wondering about Katherine Heigl's "ungratefulness" after watching her on KTLA recently. During her interview, the "Life As We Know It" actress was asked about a recent New York Times profile of her that discussed her notorious "image problem." Katherine agreed that the article was "fair," adding, "I've spent a lot of time trying to figure out where I kind of went off track and how and why and what I can do in the future to avoid that." Whether that's motivated by legitimate remorse or the fact that "Killers" totally flopped is up for grabs.
RELATED: Check out Katherine's style profile
If there's one take home message from all this, it's that Katherine is thankful for her career. (Is it just me, or is it absurd that we applaud celebrities for appreciating what they have?) "I'm really excited and grateful to be in the position that I'm in now and have the opportunity to be in movies like this movie," she said. Yeah, I'm sure she said similar things about "Grey's Anatomy," the show that plucked her from obscurity, before she dumped on her supposedly "subpar" material and then just didn't show up for work. And she probably spouted similar lines about "Knocked Up," the movie that gave her a big screen career, until she called it "sexist" in Vanity Fair. But c'mon, folks, she's grateful!
Katherine is quick to point out that in the Times, the author notes that nothing she said was "scandalous -- it just had a tone." And while she's not willing to play prim and proper all the time, she's ready to turn it down a few notches: "That's the most important thing I've learned as I get older," she says. "I can let go of the tone. I'll say what I gotta say and be honest, but maybe not so edgy." But is it really edginess that she's guilty of? Susan Sarandon, Angelina Jolie, Scarlett Johansson -- they're all "edgy" women, but they don't have her diva reputation. What do you have to say about that, Heigl?
RELATED: Katherine: 'It's time to reevaluate and grow up'
Katherine's outspokenness has been useful though, as E! Online's Ted Casablanca points out: "We hearted the babe for standing up so vocally for pal T.R. Knight during Isaiahgate," he writes, "but unfortunately her good heart was trumped by her big mouth in a lot of situations." The difference is when her behavior is selfless versus self-absorbed; mouthing off about someone who's gay-bashing versus mouthing off about your writers.
I don't think Katherine's a bad person: I just think she got caught up in being a hot commodity. It happens. Plus, Hollywood likes to create its own villains, and Katherine fit the role so perfectly. What I give Katherine credit for, however, is owning up to her past mistakes. Whether or not it would have happened voluntarily, well, that's a different story.
RELATED: Stars who have chosen to adopt
Now that Heigl's (supposedly) outgrown the bratty, smack-talking actress role, who's going to take it on? Megan Fox, we've got our eye on you.
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We're back to Adam and his last showdown, he's got Orlando Napier (who had a stupid hat during the auditions and a bluesy voice) and Karla Davis (a soccer playing college student turned country singer) doing "Rich Girl." Orlando's never heard it, so Adam introduces him to the concept of iTunes. Orlando can't hit a single note, as the whole song is way too high for him. He thinks that it might be a bad song choice, so he opts instead for The Commodores' "Easy Like Sunday Morning." Karla momentarily freaked, but she's so happy-go-lucky that she seems OK with it.
Karla gets to work with Alanis, and gets some advice on stretching her belt (a belt who gets strangely dubbed "Bertha"), and it is much improved. She does a victory lap around the piano. Aw, she's kind of cute. Another contestant who I don't totally hate. That's mildly refreshing. Orlando works with Robin Thicke, and Robin calls him a vocal painter and "the Picasso of the group." Orlando again can't hit notes and Robin has to teach him rudimentary projection tips and how to work with vowels. Adam just looks tired.
Go away, Christina Milian. Your 20 seconds of screentime are entirely pointless.
I know I complain about the tacky outfits most of these people weird, but Karla's wearing a red and black flannel shirt (that has a little sparkle in it) and she seems underdressed to sing such a soulful song. Orlando's dressed in what looks like a chef's jacket, so he's not much better off. I mean, I'd at least wear Karla's sparkly flannel for chilling out on the weekend or country line dancing (if I were ever to do that). Orlando has this whispery flatness to his voice that doesn't resonate with me, it doesn't help that he has an innately punchable face. Neither of them really knock it out of the park, but if I had to pick who I'd rather listen to/look at again, I'd go with Karla.
Blake doesn't think that anyone ran away with this battle (we agree!), and he likes Karla's voice, but Orlando's stage presence. Christina was underwhelmed or bored because she's done with her people, and reluctantly goes with Karla. Cee Lo thinks Orlando was cooler. Adam stretches it out, and then goes with Karla. She's beside herself, and has a very odd cry face. Like if she got into it, she might be able to give Carrie on Homeland a run for her money. Her dad is SUPER PSYCHED. Adam's happy to be done.
Team Blake's last pairing. I don't even care, I'm just happy that I get to see more Kelly Clarkson. His remaining people are Jordan "Son of a Preacher Man" Rager and Naia Kete, and they are doing Jason Mraz's "I'm Yours." Blake calls Jordan "country as dirt," and it's no surprise that Jordan doesn't know the song at all... even though it was played EVERYWHERE for a whole damned summer. Naia was the street performer who Carson found on the side of the road and dragged in, then she sang "The Lazy Song" and flirted shamelessly with Cee Lo. Jordan was a country singer who mostly wanted to be Team Blake to meet Miranda.


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Introduction In the Begining Proxy Wars Secret Front Lines The Race for SpaceAmerica's Cold War CultureTimeline |
In the Beginning |
"I have never been talked to like that in my life." |
Vyacheslav Molotov |
"Carry out your agreements and you won't get talked to like that." |
Harry Truman |
Many in the United States were unnerved by communism's success in Russia and in political parties throughout Europe. From 1917 to 1920 America passed through a period known as the Red Scare, where fear of political radicals and European immigrants combined with patriotism during World War I to produce laws that suppressed free speech and labor unions and exploited racial fears, resulting in the loss of property and freedom for tens of thousands.
Museum Home Library Home Education Center Home |


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Taking a look at the Lions, the Eagles' issues and more. Matt Bowen
NFL coaches want to break down the season into four quarters. Win three of four (or at least get a split) and you will be playing for something come December in this league. And after four weeks of football, I have five questions about what we have seen on the field. Let's check them out…
1. Did we overhype the Eagles?
No one predicted a 1-3 start for Vick and the Eagles back in August. And I see some real concerns for Andy Reid's ball club.
The problem with Philly isn't the skill set of Michael Vick, the talent they have outside of the numbers (on both sides of the ball) or the play of LeSean McCoy. Instead—when we look beyond the big names—it is obvious the Eagles have some issues. The O-Line is suspect, they aren't strong at the LB position and in the secondary the safety play is below average. At 1-3, the Eagles will have to string some wins together, start tackling on defense and keep Vick off the ground if they want to get back into the NFC East discussion.
2. Can we call the Packers and Saints the class of the league?
That's what I'm thinking after four weeks of football. Both clubs can move the ball on offense, have multiple weapons at the skill positions and when we break down their defenses, it is about pressure and taking the football away. I love what you get from both Dom Capers and Gregg Williams in their weekly game plans: pressure, man-coverage and unique looks that cause confussion. However, the key in Green Bay and New Orelans? The QB play. Rodgers and Brees and can put up numbers vs. any secondary in the NFL.
3. What do we make of the Steelers?
Sitting at 2-2, this isn't time to panic in Pittsburgh—but there are some serious questions about this football team. In two losses (Ravens and Texans), the Steelers were physically outplayed up front. We don't see that often, and on defense, where are the turnovers? Pittsburgh still doesn't have an interception and when combined with the sloppy play on offense, the Steelers are minus-10 in turnover ratio after four weeks. Can't survive (and beat the Ravens) playing like that. I still like this squad because I trust the scheme of Dick LeBeau and Ben Roethlisberger is a QB I want to give the ball to when I need a play. However, it is tough to look past the style of football we are seeing in Pittsburgh this season.
4. Are the Lions a legit 4-0 squad?
Don't blame the schedule for the 4-0 start, because the Lions have shown us the ability to come back, score points and make plays in crucial situations of the game. Plus, it is hard to win on Sundays in the NFL. I do have some questions about their running game and if this secondary can compete on a consistent basis with Green Bay, but there is no denying the production of Stafford and Calvin Johnson. And I want to see someone line up and run the ball on that D-Line in Detroit. This team plays hard and they should compete in the NFC North all season.
5. Which team is the biggest disappointment?
Could make a case for the Vikings (or even the Eagles) but I am going to look at the Rams here. Sam Bradford isn't playing good football, the offense isn't executing under new coordinator Josh McDaniels and they aren't making any big plays on defense. But I want to go back to Bradford. The 2010 Rookie of the Year doesn't look comfortable in McDaniels' scheme. The Rams have scored only 46 points (ranks 31st in the NFL) and that starts with the QB position. No question St. Louis has a serious lack of options in the passing game, but Bradford isn't developing at the rate we should expect after his production last season.
Follow me on Twitter: MattBowen41
JAN 20 Tony Villiotti
Following Monday's announcement of those declaring for the Draft, a look at the numbers.
JAN 19 Jeff Fedotin
Why Dave Toub deserves a head coaching job
Chiefs' special teams coordinator has unique football mind.
JAN 16 Tony Villiotti
Reviewing 2014: Scrimmage participation by playing position
Are certain positions more reliant on early round picks?


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Sales and Visual Merchandising (full-time and part-time)
The Container Store - Washington, DC This job posting is no longer available on The Container Store. Find similar jobs: Sales Visual Merchandising jobs - The Container Store jobs
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The Container Store is an innovative company that sells more than 10,000 unique storage and organization solutions. We are employee-first...


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Costa Rica
NSF offers auditing, inspection, certification, training, testing and consulting services in all countries of Central America and the Caribbean, plus Colombia. Located in San José, Costa Rica, we provide comprehensive services to companies in the agriculture, livestock, seafood, bottled water, food processing, food distribution, packaging, manufacturing, retail and hotel industries, among others. Our wide range of services includes training and consulting in the Food Safety Modernization Act (FSMA) and certification to Global Food Safety Initiative (GFSI) standards (GLOBALG.A.P., PrimusGFS, SQF, BRC, IFS and FSSC 22000). We also offer testing and certification services for food equipment, nonfood compounds, dietary supplements, drinking water system components and drinking water treatment chemicals. Additionally, management systems certification is available.
NSF International Appoints General Manager of Drinking Water Filtration Products
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Sleeps | 8 |
Bedrooms | 4 |
Bathrooms | 3 |
Half Baths | 1 |
Property type | house |
Minimum Stay | 3 nights |
# 2013010107
Beautiful Custom Built Home Located on #16 Fairway!
Privately fully fenced in property w/swimming pool & hot tub.
Paula's Place is the perfect home for family gatherings. Nestle upon your comfortable couch outside on the patio while watching your favorite shows under the stars or taking a relaxing nap, and take advantage of a the DVD Player, Wii or tune into the channels on Dish Network from your 50 in. TV Screen while relaxing on the couch(s) or loveseat in the living room. If you get sleepy, you can get to your comfy beds in just a few steps.
Since life doesn't only take place in the lounging area, your home is designed with plenty of kitchen space as well. With a kitchen large enough for preparing meals & seating 17 people down in the family room to enjoy those meals we offer Kitchen Aid double ovens, five top cooking gas range, a microwave, trash compactor, dishwasher, refrigerator, coffee grinder, coffee maker, spices and plenty of cookware. You won't be hard pressed to find what you need or to get around.
Here are some features of my home that I would like to share with you.
Great Room includes the Formal Dining (seats 8), Breakfast (seats 4), Oversized Kitchen Bar (seats 5) & the Living, Kitchen, Living, Dining and half bath are all on the main floor when you enter the home.
Master on lower level, King Bed, with direct access to pool & hot tub, Master Bath with walk-in tiled shower, garden tub & double vanity.
There are 3 more bedrooms on the upper game room level. One is a king and the other two are Full Size. The King Bedroom has it's own bathroom and the 2 double bedrooms have a Jack & Jill Bath with a separate shower and toilet.
Game Room, wet bar, pool table, baby grand piano and entertainment center that has it's own balcony overlooking the private backyard and golf course
Outdoor Propane Grill for your enjoyment
Custom Concrete Countertops & Floors throughout.
Custom Wood Shutters & Textured Walls
Custom Outdoor Decks
Surround Sound Inside and Out
Tile, Carpet, Wood & Concrete Floors
Sprinkler System
Beautiful Landscaping and lighting
Central Air & Propane
Alarm System
Outdoor Spiral Staircase from top floor that gives you direct access to the pool below.
Vaulted Ceilings
I grew up in North East Texas and went to Kilgore Jr. College 1983- 1985 following Kilgore I decided to attend school at SWTSU in San Marcos, TX. In 1987, I came to Austin to teach and coach middle school. I love Austin and I really love this town. I designed, built and finally moved into my dream home in 2001. I love watching and participating in all kinds of sports. Mainly, but certainly not limited to golf, water & snow skiing as well as water & sand volleyball! I work in sales and marketing for a local title company and have been doing so for almost 19 years! So to say the least, I work hard & smart and I play even harder!
Paula Reid Moore purchased this house in 2001
It's a beautiful home that offers peace and tranquility right outside your back door located near lots of shopping (Domain & Arboretum), restaurants and centrally located. Just 12 minutes from Downtown Austin!
Check out the link and you will see! http://www.tourfactory.com/553690
This property is located in North Austin off of Capital of Texas Hwy. also know as Hwy. 360 and South of Hwy. 183 also know as Research Blvd. near the Arboretum!
Rate Period | Nightly | Weekend Night | Weekly | Monthly * | Event | ||||
My Standard Rate
3 night minimum stay
Admin | $100 |
Property Damage Protection | $89 |
Cleaning | $250 |
Refundable damage deposit | $500 |
Tax Rate | 15.0% |
Notes | UT Longhorn Football Games, Formula One, National Holidays & various Music Festivals will be billed between $900- $1200 per night. Email me for an exact quote! |
* Approximate monthly rate. Actual rate will depend on the days of the month you stay.
Payment is usually accepted in the quoted currency (USD) unless the currency and the amount is specifically agreed in advance with the owner / advertiser.


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I've been really busy and haven't been able to share these Pictures until today For some reason I'm having trouble posting So I will save comments until the end.
DD4 and her fiancee just bought a home and this sombrero was left by the previous owners, it's perfect don't ya think? TFLookin Follow-Up Postings:
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