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VersionOne is an all-in-one agile project management tool built from the ground up to support agile software development methodologies such as Scrum, Kanban, Lean, XP, SAFe and hybrid. From small teams to distributed enterprises, VersionOne's suite of right-sized product editions help companies scale agile faster, easier and smarter.
Take advantage of more than 45 pre-built integration connectors to extend VersionOne and create a single, synchronized agile software development environment. Connectors are available for all VersionOne product editions, or you can build your own using VersionOne's open, web-service API and SDKs (Java & .NET).
We offer world class agile and product training to help you quickly get started with agile and easily scale VersionOne across your organization. Whether you're looking for basic training or dedicated on-site coaching you'll find what you need to make your transition to agile faster and easier.
VersionOne has been selected and successfully deployed by over 50,000 teams in over 170 countries around the world and more than 35 Fortune 100 companies using agile software development and scrum development practices. Our customers include many of the leading technology organizations in the world.
We realize that the agile expertise that our partners offer is a critical part of a customer's success in adopting, transitioning and scaling their agile initiatives. By leveraging the unique expertise of our global partner network, VersionOne is able to offer superior agile training, coaching and consulting services based on our customers' specific needs
VersionOne helped pioneer the agile management tool in 2002 - way before it was the cool thing to do in the software development market. Today we remain the only enterprise software company that has been 100% dedicated to agile life cycle management since day one.
Transitioning from traditional QA to agile testing is one of the biggest challenges a development team will face. The transition from QA to agile testing must preserve the benefits of QA without impacting the benefits of iterative development.
This webinar provides a detailed demonstration of two of VersionOne�s newest and most exciting features.
This white paper is based on experience with hundreds of teams around the globe including many of the Fortune 100 and presents five commonly held myths associated with agile development.
With VersionOne, we're confident that we can take code in any direction, with speed and efficiency."
Warren Elliot
Director of Development
Eos Group


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Select () or exclude () categories to narrow your recipe search.
As you select categories, the number of matching recipes will update.
Find exactly what you're looking for with the web's most powerful recipe filtering tool.
I am a retired Dentist and a High School Golf Coach who loves to cook. I love to try new recipes and tinker with them until I get my desired result. Most of my recipes are family recipes handed down thru generations. Most of the men in our family love to cook, so a lot of the recipes reflect that. I also love to share favorite recipes and hope to one day write a cookbook to pass on to my children and grandchildren.
Italian Dishes, Stews, Breads, Grilling, and anything new and different. My favorite, I guess, are simple new bread recipes.

subset: commoncrawl


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hired 2 times on Thumbtack
I offer sport, newborn, family, senior, pet, wedding and event photography.
Send me a message to request a quote for your next session.
Bethany, OK 73008
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Parks and Recreation - Tennis
Show All Answers
How do I register for a tennis class?
Call 281-210-3950 and register over the phone, or go in person to The Woodlands Recreation Center, or register online by clicking the "Register for Rec Programs" icon on this Web site.
How old does my child need to be to begin tennis lessons?
Tennis classes begin at age 3.
How do I know what skill level or class to put my child in?
Class and level descriptions are on this website. The tennis director or Lead Pro can also evaluate a child's skills to help parents determine the class and level their child needs.
How old does my child need to be to begin tennis lessons?
Tennis classes begin at age 3.
If my child is on a waiting list how soon will I know whether or not they will be able to sign up for the class?
It can range from two days before the class begins to the day of the first class.
What if I sign my child up for some classes and then the instructor wants to move them up to a more advanced class?
The recreation center staff can easily transfer them to an open class at the correct level of instruction.
What if I sign my child up for 5 months of tennis and then the instructor wants to move them to a different class in the 2nd/3rd/4th month?
The recreation center staff can easily transfer them to an open class at the correct level of instruction, and your payments till transfer too.
Who do I talk to about signing up for private tennis lessons for an adult or child?
Please see the list of Approved Township Tennis Instructors on this Web site and at the Recreation Center. Private lessons are arranged with the instructor by the participant or parent of the participant.
Will the recreation center open up more classes if the one I want is full?
Possibly, if instructors and courts are available for an additional class.
How do we know when it is time for our child to move up to the next level?
The Instructor will know based upon the child's skill level and will inform parents before it is time to enroll for the next month of classes.
What is 10 and Under Tennis?
USTA's program for children under the age of 10 to learn how to successfully play tennis. The court sizes are different and the "Speed" in which the ball bounces is slower to encourage learning and skill development.
What should my child wear and bring to class?
Temperature appropriate comfortable clothes, tennis style shoes – not running shoes, water bottle and a hat, be sure to apply sun screen before class begins.
Is it better for adults to start off in drills or lessons?
Lessons are best for beginner players since drills do not include any instruction.
What are drills?
Strategy based, fast paced repetition and movement to increase consistency in play and skill, they are also a great physical workout. Drills are usually with a group of four or more players with minor skill correction.
What should I do if I'm unable to make it to a lesson? Who do I contact?
You should contact your instructor to let hom/her know. If you do not have the instructor's contact information, you can obtain it from the Recreation Center.
Do you have a list of instructors?
Yes, please see the Approved Instructor List on the side bar of this page, or pick one up from the Recreation Center.
How much do the instructors charge for private lessons?
The fees range from $45 to $60 for an hour long lesson.
How do I get my name on the sub list for the ladder league?
Email email@example.com. You must include your name, cell number and email address. The tennis staff will add your contact information to the sub list.
Do you need my team name or team captain's name for our Jack Rabbit, North Country, or HLTA league?
No, that information is no longer needed. Team captains for each league will submit a roster, Recreation Center staff will then refer to that roster.
What should I do if I have joined a league and am unable to make it to a game?
E-mail or call someone from the Sub List who can take your place and play that day.
What days are each of the courts blown off?
Area courts are blown once or twice a week depending upon the season. Not all courts are blown.
Where do I find a list of parks with tennis courts and court numbers?
Please see the Township's Interactive pathway map on this Web site.
Can I reserve a tennis court? How much does it cost?
Yes, as long as space is available. The fee is $8 per court, per hour. How do I do this? Call 281-210-3800 and ask to reserve a tennis court.
Where would I find a list of parks with tennis courts and court numbers?
Please refer to the Township's Interactive pathway map on this Web site or pick one up at The Woodlands Township Recreation Center, 5310 Research Forest Drive, The Woodlands, 77381.
The Woodlands Township Parks and Pathway Map
Who is allowed to play on courts that are not reserved?
All courts are open to the public for tennis play. They are available on a first come first serve basis, unless someone has reserved the court and can provide a copy of their reservation permit.
If I reserved a court and someone is playing on it, what should I do?
Let them know the court is reserved and ask them to leave. If they will not leave, call 281-210-3900 and ask for a park ranger to come and assist.
What should I do if something is wrong with the court? For example, if the lights are not working or coming on, or if the net is damaged.
Please email email@example.com, please be sure to tell us which court you want to use and describe the problem on the court. We will then submit a work order for repairs to the court.
Are the times and days of the tennis classes tentative?
How soon should I register for the tennis classes?
As soon as possible, the tennis classes fill up quickly.
Why are the tennis classes monthly?
To provide consistent instruction.
Can I set up an automatic payment plan for tennis lessons?
Yes, automatic payments can be arranged at the time of registration.
Am I allowed to give my child lessons myself?
Am I allowed to give my child's friends lessons and charge for the lessons?
No, you cannot collect money for lessons or services unless you are an approved tennis contractor with The Woodlands Township Tennis Academy.
How do I choose an instructor?
You can arrange your instructor for private lessons based on your personal preference, availability and the instructors. Instructors for classes are arranged by The Woodlands Township Tennis Academy staff.
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This printable set includes: Tent Cards (blank), Tent Cards (pre-filled) Balloon Owl Decorations, Straw Flags (both blank and pre-filled), Party Circles/Cupcake Toppers, Juice Box Wraps, Bottle Wraps, Cupcake Wraps (2 styles) - Cool, huh?! :)
I love these little cute owls, and we have the guys at Hello My Sweet to thank for the gorgeous printables!
We have 26 days left of exclusive, FREE party printables coming up - Don't forget to subscribe by email (on the blog's sidebar here) so you don't miss a thing! ;)


text: Bachelor of Science in Criminal Justice Bachelor of Science > The principal objective of the Criminal Justice Program is to deliver a comprehensive program of teaching and research to support the criminal justice system and the agencies and personnel who are delegated the task of public safety and service. The goal of the program is to ensure that potential and current criminal justice personnel have the opportunity to study the most comprehensive and contemporary methods and policies dealing with administration, management, human resources, intelligence, terrorism, and cultural diversity. The program is designed to prepare students with no prior related work experience for entry level positions within the criminal justice system as well as similar positions in the private sector. For criminal justice personnel, both sworn and civilian, the program prepares them for middle and senior management positions, building upon previous experience and training. The program is developed around a core curriculum of required courses within the range of subjects applicable to criminal justice. In addition, each student is required to complete a series of liberal arts courses to assure the broadest based educational experience and to support the general education goals of the University. Further, the student will have the opportunity to select from an approved list of elective courses to develop an area of interest. See the Undergraduate Catalog for detailed degree requirements. Associate in Science > The Associate in Science in Criminal Justice Program is designed to prepare students for entry-level positions within the criminal justice system. The curriculum focuses on the critical areas within the discipline, as well as relevant liberal arts courses, to provide students with the skills necessary to function within the profession. The core criminal justice courses of the curriculum are offered in an accelerated format which requires extensive outside study as preparation to comprehensive in-class development of materials. All credits earned from this degree are acceptable and apply towards the Hodges University Baccalaureate Degree in Criminal Justice. See the Undergraduate Catalog for detailed degree requirements. More About Criminal Justice > Hodges University's Criminal Justice Program emphasizes specialty areas of concentration to prepare individuals for service in unique and innovative areas within the criminal justice system. Such specialty areas include behavioral sciences, forensics, terrorism, and intelligence. The curriculum is structured to provide a logical sequence of courses in either behavioral sciences or intelligence and terrorism for students to progress from the associate level to the bachelor's level. The professors in the Criminal Justice Program possess the appropriate academic preparation as well as the practical experience in the real world application of their craft. The program draws upon the expertise of law enforcement officers, judges, probation and parole officers, corrections personnel and practicing attorneys. The learning environment of the class is further enhanced by the interaction of the various criminal justice students already working in the field. This blend of practical experience from both the professors and the students provides a real value to the graduates of this program. As society changes, so too, will our criminal justice system. Hodges University is committed to ensuring that its Criminal Justice Program remains contemporary so that graduates of the program will be prepared to serve the communities in which they serve.Click here to view Bachelor of Science in Criminal Justice Faculty Spotlight Archive Back


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NEW YORK - Little by little, a weapon against identity theft is gaining currency — but few people know about it.
It's called the security freeze, and it lets individuals block access to their credit reports until they personally unlock the files by contacting the credit bureaus and providing a PIN code.
The process is a bit of a hassle, and the creditreporting industry believes it complicates things unnecessarily.
But it appears to be one of the few ways to virtually guarantee that a fraudster cannot open an account in your name.
The freeze became an option in California and Texas last year, and Louisiana and Vermont will allow it beginning next July. However, the Texas and Vermont laws apply only to people who already have been victimized by identity theft.
Only 2,000 Californians have taken advantage of the freeze, according to Experian, one of the three major credit bureaus.
But identity theft watchdogs say usage is low simply because the credit bureaus don't publicize the option. Advocates hope the freeze gains national momentum. Congress resisted calls for a freeze rule during debate over a major credit law last year.
''It's the best protection we have,'' said Linda Foley, executive director of the Identity Theft Resource Center in San Diego.
While the freeze may be an extreme step, its backers say it is necessary because the existing system is broken.
The Internet and consumer databases have made it easier than ever to find someone else's social security number and apply for accounts in that name. Meanwhile, obtaining credit is a breeze, as zeropercent financing offers crowd our mailboxes and appliance stores make no-money-down come-ons.
People who suspect trouble can place fraud alerts on their credit reports. But identity theft watchdogs say the alerts are often ignored by creditors who are willing, say, to gamble that the potential plasma TV purchaser in front of them is legitimate, and write off any losses that might occur if the person turns out to be a con artist.
A 2003 study for the Federal Trade Commission determined that in the previous year, 3.2 million Americans' personal information had been stolen by thieves who opened new accounts or loans. On average, victims lost $1,180 and spent 60 hours resolving the problem.
The freeze costs nothing for ID theft victims in the states it is allowed. Louisiana's freeze is also free for people 62 and older.
For everyone else in California and Louisiana, the initial freeze is $10. Unfreezing it temporarily is $8 in Louisiana and up to $12 in California. But the cost of each step is multiplied by three because it must be performed with all three major credit bureaus, Experian, Equifax and TransUnion.
With the freeze on, if someone applies for credit in your name, the creditor will be unable to check your history, and the applicant will get rejected. (The freeze won't keep credit card offers out of the mail — those are generated through a ''prescreening'' process that doesn't require full examination of your credit until you actually apply for the card.)
If you want to apply for credit or let someone run a background check on you, you have to call the credit bureaus, provide the PIN, and say who — a landlord, for example — will be inquiring about your history. Or you can thaw the credit report for a given period of time — a week in which you're shopping for cars, for example.
''It's like putting a new lock and key on your security files,'' said Bridget Thomas of Prairieville, La., who lobbied for the freeze in her state after a woman with the same name — but a different middle initial — got Thomas' social security number and went on a spending spree that wrecked Thomas' credit status.
''This gives you a modicum of control. Instead of the social security number being the old key, this PIN is your new key.''
The time or money required to freeze and unfreeze credit reports probably will dissuade many people from doing it unless they've already been badly stung by ID theft.
The credit bureaus think it isn't wise for anyone.
The industry has fought the freeze, contending that fraud alerts and new protections in last year's federal Fair and Accurate Credit Transactions Act offer significant defense against identity theft.
Consumers are accustomed to quick mortgage approvals and other conveniences that exist because banks, retailers and insurance companies have efficient access to credit histories, Ellman said. The freeze, he said, would only gum up the works and confuse people.
''It's using a machine gun to get at a fly,'' he said.
That argument angers victims like Thomas, who says the best that the existing system offers is detection of the crime, while a freeze brings invaluable protection.
''The only thing you have in this world,'' she said, ''is your name.''


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Nov 20, 2012 6:23 PM by Associated Press
NATIONAL CITY, Calif. (AP) - Authorities in San Diego County say a 14-year-old girl fought off a would-be kidnapper who was then run over by a car.
Police tell U-T San Diego (http://bit.ly/QVYIok ) that the girl and her cousin were walking home from a convenience store in National City on Monday night when a BMW driver stopped and chased them.
Sgt. Julian Villagomez says the man grappled with the 14-year-old and punched her in the face but fled when her relatives heard the noise and ran to help.
Villagomez says the man lay down in the street and was hit by a car but jumped up and ran into a Jack in the Box. The girl's relatives then blocked the door until police arrived.
The man was hospitalized but there's no word on his condition.
Offensive or inappropriate comments are subject to removal. To report a comment, please e-mail us at email@example.com, and include the name of the story and information on the comment.
Thank you! KSBY.com
40 minutes ago


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Ball Motion on Uneven Ramp Rails
Name: Bea Status: educator Grade: 6-8 Location: GA Country: N/A Date: 8/17/2005
If a ball is rolling down a slanted ramp and the sides of the ramp expand and come back to the original or more narrow width how will this affect the speed or force of the ball?
So long as the ball does not make contact with the edge of the ramp, the ball will not "know" how wide the ramp is. If the ramp has a constant slant to it, width will not matter in most situations.
If the ball does come in contact with the edge, this can cause a little sideways motion. It can also affect whether the ball slips. If the ball is extremely close to the edge, air currents within the room may affect the motion of the ball. A rigid ball of significant mass will be less affected by these things than will a rubber ball or a ball with very little weight.
When using a ramp that narrows, watch out for changes in the smoothness of the ramp. Irregularities often occur near edges. As the ramp narrows, irregularities can become closer to the ball's path.
Dr. Ken Mellendorf
Physics Instructor
Illinois Central College
Click here to return to the Physics Archives
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Update: June 2012


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Narita M et al. – This study provides a cutoff future liver remnant (FLR) ratio for safe postoperative outcome after major hepatectomy in colorectal liver metastases (CLM) patients receiving six or more cycles of preoperative chemotherapy.
Methods- Between January 2000 and August 2010, a total of 101 consecutive patients with CLM underwent major hepatectomy after preoperative chemotherapy (≥6 cycles of oxaliplatin or irinotecan regimen with or without targeted therapies).
- The FLR ratio was calculated by two formulas: actual FLR (aFLR) ratio, and standardized FLR (sFLR) ratio.
- Predictors of postoperative overall morbidity, sepsis, and liver failure were identified by univariate and multivariate analyses.
- Fifty–eight patients (57.4%) had 95 postoperative complications.
- Sepsis and postoperative liver failure occurred in 23 (22.8%) and 16 patients (15.8%), respectively.
- On univariate analysis, small aFLR ratio was significantly associated with all complications, and sFLR ratio was associated with sepsis and liver failure.
- In receiver–operating characteristic analysis, the cutoff of aFLR ratio in predicting overall morbidity, sepsis, and liver failure was 44.8, 43.1, and 37.7%, respectively, and that of sFLR ratio in predicting sepsis and liver failure was 43.6 and 48.5%, respectively.
- On multivariate analysis, these aFLR and sFLR ratio cutoffs were independent predictors of all complications and of sepsis and liver failure, respectively.


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This came up last week when I was playing CE with my goddaughters, and it seems like the oblique answer in the FAQ is controversial. If Barbarian successfully makes a deal with his opponent, does he then pillage their hand? That certainly seems like a powerful disincentive to negotiate with him unless your hand is useless.
(For the record, we played that there was no pillage upon successful negotiation... perhaps self-serving since I wasn't the one playing as Barbarian, but it made sense at the time ).


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The Ristorante Fossa Mala offers not only traditional dishes but also refined specialities. Along with the many dishes that are inspired by the traditions of Friuli and Italy, you will also find specially created courses. All this is available with comfortable seating for 60, accompanied by wines from across Italy. Furthermore, during the summer moths, you can enjoy your meal outdoors in the company of the green countryside.
High quality cuisine is the product of the obsession of our chefs and the genuine products they use. From starters to desserts, with the passion of true artistry, our chefs can assist you with any special menu needs you may have.


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The EURO 4000
Europe's most powerful diesel-electric locomotiveTwo leading partners set new standards
Vossloh–a key player on the European market for designing and manufacturing diesel locomotives–has broadened its locomotive range in cooperation with the world's most successful manufacturer of diesel-electric locomotives, Electro-Motive Diesel, Inc. (EMD). The high-powered EURO 4000, which is fitted with an EMD high-efficiency diesel engine, electric driveline and proven auxiliary equipment, has been designed and is built by Vossloh Rail Vehicles to satisfy the specific needs of passenger and freight railway operators throughout Europe. Both Vossloh Rail Vehicles and EMD enjoy an excellent international reputation thanks to their 50-year history of jointly locomotives to countries such as Spain, Israel, the UK, and the USA.
Vossloh Transportation
As part of the Vossloh Group, Vossloh Transportation is the largest manufacturer of diesel locomotives in Europe. Comprising Vossloh Locomotives in Kiel, Germany, and Vossloh Rail Vehicles in Valencia, Spain, the Vossloh Transportation business unit is dedicated to the design and production of new and innovative products that provide sustainable solutions to growing international requirements.
EMD–Electro-Motive Diesel, Inc.
Throughout its long history, EMD (formerly known as the Electro-Motive Division of General Motors) has supplied over 58,000 EMD-powered locomotives worldwide. EMD engines are reputed to be among the best locomotive engines in the world, consistently delivering superior reliability, durability, and low life-cycle costs. The extremely powerful and fuel-efficient engine that EMD supplies for the EURO 4000 is based on proven solutions for North American customers such as Union Pacific, Canadian National, Norfolk Southern, BNSF, and CSX.
The EURO 4000:
Since 2007 the EURO 4000 has been the most powerful diesel-electric locomotive available on the European market. The EURO 4000 features Co'-Co' axle configuration, two-cabin design and AC/DC traction. EMD's most fuel-efficient turbocharged V-16 two-stroke diesel engine (16-710) with electronic fuel injection serves to power the locomotive with an impressive 4,250 HP DIN. In conjunction with the optimum performance of the driveline, the unit is capable of hauling heavier and longer freight trains, thus increasing operator competitiveness and efficiency. Thanks to its high power rating and technical characteristics the EURO 4000 is fast enough to allow other passenger trains to operate at their own regular speeds without having to slow down.
Flexible operation
As the EURO 4000 runs independently of overhead power, it has a high degree of flexibility. Enhanced traction capacity means it can both be used to haul heavy trains up steep slopes as well as lighter trains at high speeds. The locomotive runs on both electrified and non-electrified lines. As a result, optimum use can be made of less busy lines and destinations can be reached more quickly. The EURO 4000 is also suitable for cross-border operations since it is easily adaptable to various European signaling systems and, last but not least, is fully prepared for ETCS installation. The EURO 4000 is fitted with a state-of-the-art communications system and GPS, the latter permitting the operator to keep track of each train at all times, choose the most favorable route and optimize logistics and intermodal activities. A GSM data transmission system ensures any M&R work required is immediatly relayed to the maintenance stations, thereby minimizing downtime.
Compliance with all European standards
The EURO 4000 was designed by leading specialists in the railway sector–Vossloh and EMD. These two companies have already supplied hundreds of customers around the world with diesel locomotives that assure a high degree of availability, optimum life-cycle costs and the added certainty of a ready supply of parts throughout the unit's service life. The EURO 4000 naturally also complies with all European norms (emissions, noise, crash, fire, etc.), is suitable for UIC-gauge lines and capable of running on rail networks throughout Europe.
Low operating costs, easy maintenance and eco-friendly
Minimum M&R costs due to:
- modular design permitting easy assembly, disassembly and complete module replacements
- amply dimensioned components with a long service life and low maintenance needs
- maximum standardization of parts and maintenance procedures
- easy access to components
- a reduced-wheelbase bogie with a high rail-adhesion factor and low maintenance costs
As maintenance has been reduced to a few simple operations, the locomotive can be in service for long periods of time. It has low fuel consumption also due to the highly efficient diesel engine, traction and optimized auxiliary systems.
Thanks to this low fuel consumption and a fuel-tank capacity of 7,000 liters the EURO 4000 can cover distances of up to 2,000 km without having to refuel, depending on nature of the operation. And it does all this with remarkably little noise since it complies with HS RST TSI standards for noise emission.
Comfort and safety
In addition to its impressive set of technical features, the EURO 4000 provides optimum driving conditions with a spacious cab offering increased visibility. The latter has been designed in accordance with the EM 12663, UIC 651 and DIN 5566 standards and includes state-of-the-art, European-style controls. Finally, the cab is separately air-conditioned, assuring agreeable conditions for the driver.
The shock-resistant, DIN 5566-compliant windshield not only further enhances the driver's safety but also ensures minimum noise levels in the cab, which features fire-protection in accordance with EN 45.545. Finally, the integrated TSI CR crash system makes sure both the driver and the locomotive are protected in the event of a collision.
The locomotive complies with UIC 518 gauge standards in terms of track strain, safety, and performance. It conforms with EN 12299 regarding ride comfort.
- Most powerful diesel-electric locomotive available on the European market
- Cross-border capability as the locomotive can run independently of overhead power
- Problem-free haulage of heavy trains up high slopes and light trains at higher speeds, thus improving operator competitiveness and efficiency
- Optional state-of-the-art telemetry system including GPS and GSM data transmission
- Prepared for ETCS
- Parts availability throughout the locomotive's service life
- Modular design
- Two air-conditioned cabs
- Maximum standardization of parts and maintenance procedures
- Covers distances of up to 2,000 km without having to refuel thanks to low fuel consumption and ample 7,000-litre fuel tank capacity


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Nolz Lab Research Interests
Trafficking of T cells out of the circulation and into various tissues is a highly orchestrated process involving multiple receptor – ligand interactions. In my laboratory, we utilize a wide variety of disease models combined with molecular and cellular approaches aimed at ultimately understanding the biochemical signals that dictate T cell localization in vivo.
The selectin family of proteins (L-, P-, and E-selectin) play a critical role in regulating immune cell trafficking and facilitate the initial interactions between T cells and vascular endothelium prior to chemokine-mediated signaling and integrin activation (Figure 1). Importantly, ligands for selectins require post-translational glycosylation (Figure 2) to become functional and both CD8+ and CD4+ T cells exhibit dynamic regulation of the enzymes that are responsible for generating these O-linked glycan structures. Furthermore, we have recently discovered that the generation of core 2 O-glycans within memory CD8+ T cell populations occurs in an antigen-independent manner, but rather is controlled by inflammatory cytokines (Figure 3). In addition, we have shown that this is a major regulatory mechanism controlling memory CD8+ T cell recruitment to inflamed tissue prior to antigen re-encounter. Thus, a comprehensive understanding of the molecular and biological mechanisms that regulate T cell O-glycan synthesis and trafficking could ultimately result in new disease prevention strategies by therapeutically directing (for vaccines and tumor immunotherapy) or inhibiting (for autoimmunity) T cell recruitment to target tissues.
Current projects in the laboratory include:
1) Mechanisms of CD8+ and CD4+ T cell recruitment to inflamed tissues and tumors
2) Molecular and biochemical regulation of core 2 O-glycan synthesis in memory CD8+ T cell populations
3) Regulation of core 2 O-glycan synthesis and T cell trafficking during chronic infections
4) T cell-mediated immunity against viral infection of peripheral tissues
5) T cell-mediated tumor immunotherapy
Figure 3: Naive CD8+ T cells express core 1 O-glycans, but not core 2 O-glycans and cannot bind to P- or E-selectin. Following antigen encounter, CD8+ T cells rapidly express extended core 2 O-glycans, bind to P- and E-selectin, and undergo chromatin remodeling at the Gcnt1 gene locus. Over time, most memory CD8+ T cells lose expression of core 2 O-glycans and cannot bind to P- or E-selectin during the steady state (non-inflamed) environment. However, the Gcnt1 gene locus remains in an open chromatin configuration and, following exposure to IL-15 during an inflammatory challenge, will rapidly generate core 2 O-glycans, bind to both P- and E-selectin, and efficiently localize to inflamed tissue.


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Item # LEKD3202 |
Reg. Price: $169.95
Sale Price: $109.95
You save $60.00 (35%)
End of Season Clearance!
In Stock! Ships Monday, January 26.
Ideal for hikers, mountaineers or trail-runners who value maximum collapsibility but aren't willing to skimp on adjustability, LEKI Micro Vario Ti aluminum trekking poles offer durable performance in pack-friendly dimensions.
Incorporating an ergonomic angle that preserves a natural position for your wrists, lightweight AERGON Thermo grips have an ovoid shape that can be palmed or held traditionally. A rubberized, dimpled top offers a textured grip point and easy-adjust straps reduce stress on your wrists and provide additional security and comfort. The extended length of the grips allows you to grasp lower on the shaft, eliminating the need to shorten the length of the poles every time you encounter a steep slope or side hill traverse.
The Speed Lock System consists of a concealed inner cord that runs through all three sections of the Micro Vario Ti poles. After each shaft section is aligned, the external Speed Lock lever flips down to tension the pole and lock each section securely in place. This innovate design saves weight and increases collapsibility while still delivering surprising strength and a short range of adjustability of 43.5"-51".
Carbide flex tips deflect up to 30 degrees without damaging the lower pole sections. This reduces the risk of pole breakage if poles get caught between rocks or tree roots on the trail. Small profile trekking baskets are included and are interchangeable with a simple screw on/off design that stays secure. Optional snowflake and deep powder baskets (sold separately) allow Micro Vario Ti poles to be converted for winter use.
LEKI Micro Vario Ti trekking poles are sold in pairs.
LEKI part number: T637 2075
Designed to fit over the ends of LEKI trekking poles and other comparable manufacturer's poles, LEKI Rubber Walking Tips allow you to use your trekking poles for inline skating, moderate Nordic walking or any other indoor or pavement activity.
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Lonely Planet's top 10 Toronto hotspots
On a clear day the views from the CN Tower are absolutely outstanding. (Eoin Clarke/LPI).
A jigsaw puzzle of distinctly flavoured neighbourhoods, Toronto only really makes sense when you view it as a whole. But who wants to do that? Half the fun of being here is pretending you are eating noodles in Macau, wandering along a leafy Dublin backstreet or sipping ouzo in Athens. This is a city that takes the best of world cultures and delivers it to you in compact, neighbourhood-sized pieces. Graze from 'hood to 'hood, focusing on the parts without trying to define the whole. Here are ten of the best spots to visit.
CN Tower
This funky spike remains every bit as cool and iconic as it was when it opened in 1976. Its primary function is as a radio and TV communications tower, but riding the great glass elevators up the highest freestanding structure (553m) in the western hemisphere is one of those things in life you just have to do. On a clear day, the views from the Observation Deck are absolutely astounding. For extra thrills, tread lightly over the knee-trembling Glass Floor deck, or continue climbing an extra 101m to the uppermost SkyPod viewing area.
Air Canada Centre
Guided "inner workings" tours of the home of the Toronto Maple Leafs (hockey) and Toronto Raptors (basketball) take you where the players go, even into the dressing room, sans players. But you will enjoy the hi-tech arena more if you can actually score tickets to a game. Tours run hourly, events permitting, and highlight remnants of the 1941 moderne Toronto Postal Delivery Building that are incorporated into the structure of the ACC, which opened for business in 1999.
Toronto Islands
Once upon a time, there were no Toronto Islands. There was only an immense sandbar. On 13 April, 1858, a hurricane blasted through the sandbar, swallowed the hotel and created the gap now known as the Eastern Channel. Toronto's jewel-like islands were born - nearly two-dozen isles covering 600 acres. When you visit the close-knit, 800-strong artistic communities on Algonquin Island and Ward's Island, expect pangs of jealousy. They have a peaceful, trusting, kid-safe community, little pollution, photogenic clusters of cottages among tall maples and incredible city skyline views.
Kensington Market
Tattered around the edges, elegantly wasted Kensington Market is multicultural Toronto at its most authentic. Predictably, eating here is a joy. Shopping here is also a blast; local specialties include fresh produce, baked goods, vintage duds and discount clothing. Lining the underbelly of Kensington Market is a seamy bohemian element. The streets are full of artists, urban hippies, punks, potheads, junkies, dealers, bikers, goths, musicians and anarchists. Shady characters on bicycles whisper their drug menus to you as they slide slowly past; hooch and Hendrix waft through the air; graffiti says, "Resistance is Fertile!" The streets simmer with a mildly menacing, hung-over vibe, but it is rarely unsafe.
Royal Ontario Museum
ROM's collections bounce between natural science, ancient civilization and art exhibits. The Chinese temple sculptures, Gallery of Korean Art, and costume and textile collections are some of the best in the world. Do not miss the cedar crest poles carved by First Nations tribes in British Columbia; the largest pole (85m) was shipped from the West Coast by train, then lowered through the museum roof, leaving only centimetres to spare.
Museum of Contemporary Canadian Art
The new MOCCA, recently relocated from far northern Yonge St, is the city's only museum mandated to collect and promote works by living Canadian visual artists. It says a lot about West Queen West's consolidation as an arts and design strip that the museum chose this district for its new facility. The permanent holdings only number about 400 works, curated since 1985, but award-winning exhibitions focus on new artists from Nova Scotia to British Columbia.
The Beaches
To residents, "The Beach" is a neighbourhood of wealthy professionals down by the lakeshore. To everyone else, it is part of "The Beaches" - meaning the neighbourhood, the beaches and the parklands along Lake Ontario. Development took off here during the 1970s and the onslaught of beachfront construction has not stopped since. Fortunately, the side streets east of Woodbine Ave still have gardens bursting with colour and quaint lakeside houses. The three beaches themselves - Woodbine, Kew and Balmy - are good for sunbathing and picnicking.
The upper crust of Toronto's districts, luxury - at a price - can be found at Bloor-Yorkville, dubbed Toronto's "Mink Mile." It is worth exploring, as some of Toronto's most unique and specialized shops can be found in this area's nooks and crannies.
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