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Barbara Campling, MD
925 Chestnut Street
Suite 220A
Philadelphia, PA 19107
(215) 955-8874
Suite 220A
Philadelphia, PA 19107
(215) 955-8874
Most Recent Peer-reviewed Publications
- Modeling the overall survival of patients with advanced-stage non-small cell lung cancer using data of routine laboratory tests
- Current management of locally advanced head and neck cancer: The combination of chemotherapy with locoregional treatments
- Acute activation, desensitization and smoldering activation of human acetylcholine receptors
- Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab
- Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis
- Treatment-related acute esophagitis for patients with locoregionally advanced non-small cell lung cancer treated with involved-field Radiotherapy and concurrent chemotherapy
- Spontaneous smoking cessation before lung cancer diagnosis
- The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer
- The problem of platinum resistance
- A population-based study of lung carcinoma in Pennsylvania: Comparison of Veterans Administration and Civilian Populations
- Practice guideline for the role of combination chemotherapy in the initial management of limited-stage small-cell lung cancer
- Topotecan in small cell lung cancer: First or second line?
- Clinical implication of p53 mutation in lung cancer
- Clinical implications of p53 mutations in lung cancer.
- Therapy and disease concepts: The history (and future?) of antimony in cancer
- Constitutive activation of Met kinase in non-small-cell lung carcinomas correlates with anchorage-independent cell survival
- Clinical and molecular features of small cell lung cancer
- The role of single-agent docetaxel as second-line treatment for advanced non-small-cell lung cancer
- Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: Correlation of protein levels with drug response and messenger RNA levels
- Enhanced anti-cancer activities of some derivatives of titanocene dichloride


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We can only hope that one day soon there'll be no reason to single out women as a specific category when we look at up-and-comers in the world of business. But the current reality is this: While the number of U.S. companies owned by women is increasing faster than those of other groups, those companies are responsible for just 6 percent of the country's employees and 4 percent of revenue, according to a 2012 report commissioned by American Express Open. Meanwhile, many studies maintain that women have significantly reduced access to capital and encounter less favorable loan rates. And don't get us started on the discrepancies in compensation between men and women performing equal work.
As relevant (and dispiriting) as these financial truths may be, they are at odds with the fact that fundamentally women are a more powerful presence in business than ever, as a work force and as entrepreneurs, technicians and corporate leaders. Here, we've identified innovators from several significant sectors: science, technology, retail and health, not to mention social and business services. We are certain their contributions and influence will have a profound impact going forward.
Sophia Amoruso, Tastemaker
By Jennifer Wang
If Sophia Amoruso has her way, the world is about to get a lot more nasty. Last year the 28-year-old founder and CEO of Nasty Gal, an online purveyor of new and vintage fashion for women, rocketed to prominence from seemingly nowhere after scoring a $40 million round of funding from Index Ventures--investors in Skype, Dropbox and Blue Bottle Coffee. For a retailer with scant discounting and zero debt, Nasty Gal has racked up some seriously drool-worthy numbers: international sales of $128 million in 2012, four times higher than the year before; 535,000 Facebook fans; 420,000 Instagram subscribers; 68,000 Twitter followers; and more than 2 million monthly unique visitors to the website in September 2012.
In 2006 Amoruso was in her garage, watching bids roll in for the one-of-a-kind vintage clothing pieces she had put up on her eBay store. Seven years later she's got a view from Nasty Gal's 10,000-square-foot digs in downtown Los Angeles, boasting arched windows, high ceilings and droves of impossibly cool guys and gals. The bob-haired, bright-lipsticked Amoruso herself arrives in a rock 'n' roll black flared miniskirt, blue sneakers and a rainbow-fringed shag jacket.
At the heart of the brand's success is Amoruso's drive to satisfy the "crazy, freakishly loyal" community that clamors for Nasty Gal's ultra-affordable, young-skewing new merchandise, which is curated from an array of up-and-coming designers, as well as vintage items from luxury brands. "I will never stop making things and imagining cool and trippy things for those girls, and that will become a bigger part of what we do," she says.
Right now Amoruso is on the hunt for more office space in the neighborhood to house her ever-expanding staff--150 employees and counting, with 65 hires in 2012 alone--including executive talent poached from Stella & Dot, Shopzilla, Amazon, Jawbone and Gap. That's in addition to a 500,000-square-foot warehouse that opened in the fall in Louisville, Ky.; the launch of a mobile site; and the simultaneous debut of the biennial Super Nasty print magazine and the brand's first in-house collection, Weird Science, featuring color palettes inspired by computer cables and prints based on data-corruption visuals.
All this, Amoruso asserts, is just the beginning. "We are transitioning from a retailer to a full-fledged brand," she says. "Part of the reason I got to where I am is I never set a goal or look at the top. I like figuring out how to do things myself, and I like the idea of creating an online brand that will last a long time."
Like this article? Get this issue right now on iPad, Nook or Kindle Fire.
This article was originally published in the January 2013 print edition of Entrepreneur with the headline: Women to Watch.

subset: commoncrawl


text: How to Request Public Records Requests for public records can be submitted directly to the department from which a requestor is seeking information by contacting the appropriate Public Records Act Coordinator. Requests can also be submitted to the Open Government Manager or to the Office of the City Clerk. Public Records can be requested in writing, via the mail, email, or fax. Requests may also be made verbally on the phone or in person. However, to avoid confusion and to make certain that you obtain the records you want, it is best to put your request in writing. Although not required, the Public Records Request form is available online to assist requestors. Try to be as clear as possible when requesting records and put date limits on your request. Offer any search clues you can and if you are informed that the records you are requesting do not exist, discuss alternatives with the City staff to whom you are making the request. Fees & Charges for Duplicating The City does not charge for the time and costs incurred in searching for, locating, or collecting records. However, the City may charge for the actual costs of duplicating paper records. The current fee is $.23 per page and postage. The City may also charge for duplicating a record from one medium to another. Requestors of electronic records generally must pay for the cost of programming and computer services necessary to produce records that are not routinely produced.However, the City does not charge for access to data that is readily accessible without significant cost to the City. Appeals If you believe that you have been inappropriately denied access to City of San José public records, you may appeal that denial by contacting either the Open Government Manager by email or phone at (408) 535-8120 of the City Council Rules and Open Government Committee by emailing the Office of the City Clerk or calling (408) 535-1260 You may also file a lawsuit with the Santa Clara County Superior Court. Learn more about the public records appeal process.


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Even more strangely for me, I am imagining it combined with big red spots on a white background. No way do I have such a colour in my stash.
Where are all these peculiar thoughts coming from?
Where are all these peculiar thoughts coming from?
Somebody say red spots???
yes I agree a very non Erica fabric - I went on a binge last year and for no real reason bought up a swag of dark browns and virulent citrus-y greens ... not moi at all but I'm sure that there was a reason ... or will be
[ and I lurvelurvelurve the photo of that marvelous orange fungi ]
here are all these strange thoughts soming from? MO design walls
I don't know Erica, but I have them from time to time too, and I don't usually do pretty either!


text: Niger Previous: #126 Pakistan Next: #128 Mozambique overall score55.1 world rank127 Rule of Law Property Rights30.0 Freedom From Corruption26.0 Limited Government Government Spending88.4 Fiscal Freedom76.8 Regulatory Efficiency Business Freedom35.2 Labor Freedom45.4 Monetary Freedom88.3 Open Markets Trade Freedom65.6 Investment Freedom55.0 Financial Freedom40.0 Embed This Data Create a Comparison Chart See how Niger compares to another country using any of the measures in the Index. vs Read more about Niger Economy. See more from the 2014 Index. Close Download PDF Quick Facts Population: 16.1 million GDP (PPP): $13.1 billion 11.2% growth 6.4% 5-year compound annual growth $815 per capita Unemployment: Inflation (CPI): 0.5% FDI Inflow: $793.4 million Embed This Data Niger's economic freedom score is 55.1, making its economy the 127th freest in the 2014 Index. Its score has increased by 1.2 points since last year, with improvements in the control of government spending, labor freedom, monetary freedom, and freedom from corruption outweighing a substantial decline in trade freedom. Niger is ranked 24th out of 46 countries in the Sub-Saharan Africa region, and its overall score is slightly above the regional average.Niger was first graded in the 1996 Index and since then has advanced its economic freedom score by over 9 points, reaching its highest score ever in the 2014 Index. Its scores have improved in seven of the 10 categories of economic freedom, especially market openness as measured through trade freedom, investment freedom, and financial freedom, although its business freedom has lagged compared to other countries.Effective implementation of deeper institutional reforms is critical to sustaining Niger's high levels of economic growth and ensuring long-term development. Systemic weaknesses linger in the protection of property rights and the effective enforcement of anti-corruption measures. The judiciary remains vulnerable to political influence. Read more about Niger Economy. Close Background President Mamadou Tandja was overthrown in 2010. Opposition leader Mahamadou Issoufou won elections in March 2011 and was inaugurated as president in April 2011. His political coalition also won a majority in the National Assembly. A Tuareg rebellion in northern Niger, spillover violence from conflicts in Libya and Mali, and the growing presence of al-Qaeda–linked groups remain serious threats. Niger is one of the world's poorest countries. With the exception of uranium, its substantial mineral resources, including petroleum and gold, have yet to be exploited. About 80 percent of the population depends on subsistence agriculture and herding. Infrastructure is poor, and extended periods of drought hinder food production. Niger is a major transit point for human trafficking. Rule of LawView Methodology Property Rights 30.0 Create a Graph using this measurement Freedom From Corruption 26.0 Create a Graph using this measurement The civilian government that took office in 2011 has committed itself to improving governance, implementing reforms, and supporting national reconciliation. However, corruption remains a serious problem, and observers have raised concerns regarding uranium-mining contracts. The rule of law is hampered by an ineffective judicial framework, and a weak court system remains vulnerable to political interference. Limited GovernmentView Methodology Government Spending 88.4 Create a Graph using this measurement Fiscal Freedom 76.8 Create a Graph using this measurement The top individual income tax rate is 35 percent, and the top corporate tax rate is 30 percent. Other taxes include a tax on interest and a capital gains tax. The overall tax burden equals 14.1 percent of gross domestic income. Government spending is equivalent to 20 percent of the domestic economy. Public debt has reached over 30 percent of GDP. Strong uranium-mining revenue should help the government cope with a recurring food crisis. Regulatory EfficiencyView Methodology Business Freedom 35.2 Create a Graph using this measurement Labor Freedom 45.4 Create a Graph using this measurement Monetary Freedom 88.3 Create a Graph using this measurement The burdensome regulatory framework hampers private-sector development. Inconsistent regulations impose substantial costs on business operations. The cost of completing licensing requirements is still over 10 times the level of annual average income. The labor market is poorly developed, and much of the labor force works in the informal sector. The state influences prices through state-owned utilities. Open MarketsView Methodology Trade Freedom 65.6 Create a Graph using this measurement Investment Freedom 55.0 Create a Graph using this measurement Financial Freedom 40.0 Create a Graph using this measurement Niger's average tariff rate is 9.7 percent. Tariffs are highest on products that compete with domestic industries. It can take weeks to import goods. The country's laws generally treat domestic and foreign investors equally. Some progress has been made toward modernizing the financial sector, but the number of available financial options for starting and expanding private businesses is limited. Country's Score Over Time Country Comparisons Regional Ranking rank country overall change 1Mauritius76.5-0.4 2Botswana721.4 3Cape Verde66.12.4 4Rwanda64.70.6 5Ghana64.22.9 6South Africa62.50.7 7Madagascar61.7-0.3 8Swaziland61.24.0 9Zambia60.41.7 10Uganda59.9-1.2 11The Gambia59.50.7 12Namibia59.4-0.9 13Burkina Faso58.9-1.0 14Gabon57.80.0 15Tanzania57.8-0.1 16Côte d'Ivoire 57.73.6 17Kenya57.11.2 18Benin57.1-0.5 19Seychelles56.21.3 20Djibouti55.92.0 21Mali55.5-0.9 22Malawi55.40.1 23Senegal55.4-0.1 24Niger55.11.2 25Mozambique 550.0 26Nigeria54.3-0.8 27Guinea53.52.3 28Mauritania53.20.9 29Cameroon52.60.3 30Liberia52.43.1 31Burundi51.42.4 32Comoros51.43.9 33Guinea-Bissau51.30.2 34Sierra Leone50.52.2 35Ethiopia500.6 36Togo49.91.1 37Lesotho49.51.6 38São Tomé and Príncipe 48.80.8 39Angola47.70.4 40Central African Republic46.7-3.7 41Chad44.5-0.7 42Equatorial Guinea44.42.1 43Republic of Congo 43.70.2 44Democratic Republic of Congo40.61.0 45Eritrea38.52.2 46Zimbabwe35.56.9 See Entire Region List › View all countries ›


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15 Oct 2011 | #1 |
Would this hybrid HDD improve performance by much?
Newegg.com - Seagate Momentus XT ST95005620AS 500GB 7200 RPM 32MB Cache 2.5" SATA 3.0Gb/s with NCQ Solid State Hybrid Drive -Bare Drive
I'm considering putting that drive into my laptop. Specs of the laptop: Intel Core i7 740 QM 8 GB 1333 MHz DDR3 Radeon HD 5650 1 GB 500 GB 7200 RPM HDD 16 MB Cache Windows 8 Developer Preview Would this improve performance by much as far as boot speed and hard disk intensive apps? Or would I be basically throwing money down the drain ? |
My System Specs |
15 Oct 2011 | #2 |
I'd totally go for it. *drools*
My System Specs |
26 Oct 2011 | #3 |
just replaced my 250gb sata drive in my acer t650 desktop with one. boots about 50% faster. apps, like firefox, seem to load & run faster too.
originally ordered a 320gb version, but they were out of stock & i was told that seagates plant got flooded, so no more deliveries till around january. i had just seen the news over the weekend about the floods in thailand, & SE Asia, so i gather that's what they meant. my supplier actually had the 500gb in stock, so i had them send it instead. so far so good. if you decide to get one, be quick before stocks go. interesting tests on seagate's site. seems drive is equivalent to a velociraptor drive & is much faster than a 10000rpm or 7200 rpm equivalent conventional hdd, but slower than a real ssd. seagate uses a 4gb 'adaptive memory' chip to form a read cache that learns from your useage. it also has a more std. but larger than normal 32mb r/w cache. the system rating for my old hdd was 5.5, new hybrid is 5.9. interesting video on it HERE |
My System Specs |
26 Oct 2011 | #4 |
youll see read speads of about 270-300Mbps so about 2/3rds that of an SSD
They only come into their own after a few boot cycles once they have built up sufficient data on the SSD cache |
My System Specs |
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[1174] DOG1: A Novel Marker of Salivary Acinar Differentiation.
Jacinthe Chenevert, Umamaheswar Duvvuri, Jean H Kim, Raja R Seethala. University of Pittsburgh Medical Center, PA
Background: DOG1 (TMEM16A) is a calcium-activated chlorine channel expressed in a variety of normal and tumor tissues, most notably gastrointestinal stromal tumors. In murine models, DOG1 is highly expressed in salivary gland acini and noted to be critical for saliva secretion. We herein validate this finding in human salivary tissues and describe its distribution in normal salivary tissues and tumors.
Design: TMEM16A mRNA levels were evaluated by quantitative RT-PCR in 10 normal parotid and 10 normal squamous epithelial frozen tissue samples. Immunohistochemical staining for DOG1 (Clone 1.1, Zeta Co, Sierra Madre, CA, dilution: 1:50) was then performed on paraffin sections from 30 parotid tumors (25 with adjacent normal) as well as 3 submandibular sialadenitis cases and one sinonasal mucoserous gland biopsy. Tumors consisted of 18 acinic cell carcinomas (AciCC) and 12 non AciCC (6 salivary duct carcinomas, 4 pleomorphic adenomas, 1 Warthin tumor, and 1 sebaceous lymphadenoma). Immunohistochemical parameters evaluated included: cell type distribution, % of cells, intensity (scale: 0-3) and subcellular localization.
Results: TMEM16A mRNA levels were significantly higher (5-fold increase, p<0.05) in normal parotid tissue as compared to squamous epithelium. Immunohistochemical evaluation for DOG1 demonstrated diffuse 2+ apical (luminal) staining in normal serous acini in all non neoplastic salivary tissue types, 1+ apical staining in mucous acini, and very focal 1+ staining of intercalated ducts. Myoepithelial cells, striated and excretory ducts were all invariably negative. In tumors, DOG1 staining was almost entirely restricted to AciCC. All 18 cases contained 3+ apical staining with 16 cases showing diffuse staining (100% of cells). Truly solid areas showed far less apical staining, while areas with mainly vacuolated cells had only focal 1-2+ staining compared to other cell types in AciCC. 15/18 cases showed cytoplasmic staining 1-2+ and 10/18 cases showed membranous staining 1-2+. All the non-AciCC tested so far are largely negative, though 1+ apical staining was noted in scattered ducts of pleomorphic adenoma.
Conclusions: DOG1 is highly expressed in human salivary acini. It is retained in AciCC and can potentially serve as a marker of acinar differentiation. A preliminary survey of non-AciCC supports the specificity of DOG1 though this must be validated.
Category: Head & Neck
Monday, February 28, 2011 9:30 AM
Poster Session I Stowell-Orbison/Surgical Pathology/Autopsy Awards Poster Session # 158, Monday Morning


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Who do you think looks best today? (5 photos)
The best street style from London Fashion Week: http://ow.ly/p48HS via @StyleCaster
"Nothing opens up eyes at the end of the day like recurling your lashes," says Stiles. Crimping alone will do the trick, but a few swipes of clear mascara will help set your handiwork while avoiding the chunky mess you can get from too many layers of black. (Bonus: Clear mascara also doubles as brow gel.)
Laura Mercier eyelash curler, $16; at Nordstrom.Read MoreLess


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The week of SHOWS for the DCC took place Oct. 17-23 – Show Group Shows, Halftime Shows and Television Shows!
Our Show Group was the featured performers at three corporate events during that week in addition to nightly rehearsals in preparation for Oct. 23 game when the Cowboys defeated the St. Louis Rams.
We were working on our huge Halloween halftime show with elaborate costumes and a thrilling musical score.
Our cast of dancers included 34 Dallas Cowboys Cheerleaders, of course, who were joined by the legendary Kilgore College Rangerettes and dancers from the area representing several studios: Studio M Dance, Kitty Carter Dance Factory, Legacy Dance Centre, Coppell Dance Centre, Prodigy Dance and Performing Arts Centre, and our own Rhythm and Blues Dancers.
Also, the DCC's national television show on CMT, Making the Team: Season 6, debuted on Oct. 20 at 9:00 pm Central.
Cheers to a great week!


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"RACE WEEK " HAPPENINGS AT THE HOUSE HOTELThis year at The House Hotel, you can put your feet up and sip a glass of champers in our "Relax Lounge" or dance the evening away in our Cocktail Bar where we will have live entertainment, DJ's, BBQ's, fresh and fun cocktails, plus our Bistro Menu which will be served from 5pm every evening.
Entertainment on Wednesday, Thursday, Friday, Saturday & Sunday from 10pm that will definitely get you on the dance floor.All eyes will be on The House Hotel Ladies Thursday night at the Best Dressed Lady Competition. With fantastic prizes up for grabs for the winning outfit, including gifts from some fabulous Galway favoutites all topped off with cocktails and a luxurious night's stay in The House Hotel's swanky suite!
MONDAY TO SUNDAY The House Bistro & Cocktail Bar opens from 12pm till late to reserve your corner or book your table call us now – 091 538 900091 538 900Alternatively if you are feeling a bit peckish during race week, pop into us and we will be more than happy to look after you…
Wednesday to Sunday entertainment starts at 10pm wednesday to saturday & courtyard BBQ is served from 10pm
For more information or any questions you may have just ask us….
2 nights treat with festival cocktail on arrival to brighten up those winter days....
The Ultimate Romantic Getaway... from only €75pps


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Latest News
VIDEO: Snooki Drops F-Bomb During Drunken Arrest
Remember when Snooki was arrested last summer for being drunk and being "criminally annoying?" That was in late July, and now for the first ti… READ MORE
VIDEO: No Sex — But Plenty Of Violence — On Jersey Shore
On Thursday's episode of MTV's smash hit Jersey Shore, J-WOWW and Sammi continued their knock-down, drag-out brawl, while the man with the golden a… READ MORE
PHOTOS: Stars Strip Down And Show Off Their Golden Globes!
These sexy stars may not be nominated for any big awards on Sunday, but they sure do deserve recognition for their Golden Globes.
PHOTOS: Booty Or Bust!? Bikini Bods From Every Angle
From the front to the back, these bikini babes are sexy without a doubt, but what are their most impressive assets? RadarOnline.com puts your favorite swim… READ MORE
VIDEO: Snooki, J-WOWW & Deena: 'We're NOT Wh*res!R...
Those wacky Jersey Shore girls want you to know they're not what you think they are.
Watch the video on RadarOnline.com
To the beat of LMFAO's &… READ MORE
EXCLUSIVE VIDEO BLOG: Snooki's Ex Emilio Talks Jersey Shore Seas...
Snooki's ex Emilio Masella gave us his brutally-honest, inside take on the free-for-all that was Jersey Shore's third season opener, in th… READ MORE
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Deena Cortese made a bold first impression in her Jersey Shore debut, stripping for The Situation and calling Sammi "Sweetheart" Giancola t… READ MORE
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The glorification of binge drinking has drenched MTV's Jersey Shore in controversy, and now RadarOnline.com has obtained exclusive photos that s… READ MORE
VIDEO: Drunken Deena Exposed Herself To The Situation On Day They Met
The cast of Jersey Shore (without Snooki) appeared on Good Morning America Thursday, as the third season of MTV's smash-hit hit is set to premiere.
EXCLUSIVE INTERVIEW: Jersey Shore's Angelina Tells Radar —...
Jersey Shore's Angelina Pivarnick has turned on former co-star Vinny Guadagnino, telling RadarOnline.com: "He is a bully and a hyprocite.… READ MORE
PHOTOS: Bikinis! The Sexiest 2011 Calendar Girls Stripped Down
From winter to summer, these smoking bikini bodies will be splashed on the walls all over the world, in the form of 2011 calendars. From Jersey Shore and Goss… READ MORE
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Jersey Shore was the pop culture sensation of 2010, and to complete their big year before the third season kick-off, the stars of the show all have exciting … READ MORE
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Pauly D's Jersey Shore spin-off has a working title. The show is being called Pauly's World, RadarOnline.com has exclusively learned.
EXCLUSIVE: Jersey Shore's Pauly D Gets His Own Show!
Paul "DJ Pauly D" Delvecchio is the first cast mate to be chosen by MTV to have his own show!
RadarOnline.com was the first to report that the spiky haired DJ of… READ MORE
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Elevated liver enzymes are an indicator of inflammation, an imbalance in the liver, or damage to the liver and liver cells. When a liver is not healthy, imbalanced or inflammed, the liver cells release or leak higher levels of certain chemicals which are an indicator of the imbalance that exists. These chemicals are measured by way of a blood test that will measure these elevated levels.
What Blood Tests Show Elevated Enzyme Levels?
What Causes Elevated Enzyme Levels?
Many conditions and ultimately liver diseases can contribute to elevated enzyme levels. These could be catagorized into short term or longterm conditions.
This list is certainly not all inclusive.
Can Liver Complete address any of these issues?
We believe it can. We have had clients that have used Liver Complete and have had significant improvements in a short period of time. Additional studies are being done, but we are confident as to the ability of Liver Complete to cleanse the liver, gallbladder, and pancreas while having the benefit of restoring mineral, pH and bile levels.
The strong ingredients used in Liver Complete have been doctor recommended for those involved with radiation and chemo-therapy treatments. It is a recommended treatment during and after the treatment due to the non-narcotic pain reducing capability, the cleansing abilities on the liver, as well as the healing and cellular rejuvination properties of the formula. Liver Complete have been used successfully in resolving issues with jaundice, toxic liver and hepatitis. The formula can eliminate ABP, also know as acalculous biliary pain which is caused when nomal bile flow is not properly moving due to sludge, debris or gallstones in the gallbladder. It can be used short term as a fast and effective cleanse or long term on a maintenance or preventative measure or as a means to correct long term, any imbalances or illnesses that might exist.
Long story short, it is not a miracle cure for everyone and as is the case with all things, it does not solve all problems for everyone. Despite the amazingly strong results for most, it has not worked on a few things for some. Sadly enough, it hurts any time there is a failure in not being able to resolve ever single health issue for every single person.


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Note: The 2012, 2013, 2014, 2015 publications have not been audited.
Jump to: Publications | Grants and Consultancies | HDR completions
Margaret Hicks may be from another institution or only recently joined Deakin University.
2014 External
Holt, Dale, Palmer, Stuart, Quealy, James, Munro, Judy, Solomonides, Ian*, Gosper, Maree*, Louka, Amgad*, Allan, Garry*, Hollenbeck, Robert*, Hicks, Margaret* and Sankey, Michael* (2014) Quality management of online learning environments: An evidence-based approach to implementing the 6EOLE Quality Management Framework, Australian Government, Office for Learning and Teaching, Sydney, NSW [A6]
DRO entry for this publication
No grants and/or consultancies found or audited – the 2014 HERDC financial return has not been completed or loaded as yet.
No completions found or audited.
DRO to publications collection last synchronised: Sunday 1st February 2015 10:04pm


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Article Last Updated: Friday, January 18, 2013 4:21pm
Sam Green/Cortez Journal
Jordan Ricca romps in the snow with her dogs, Graham and Rosebud. With school getting out early on Wednesdays, she has more play time in the middle of the week.
Email announcements to firstname.lastname@example.com and include "Community Calendar" in the subject field. Items submitted less than two weeks in advance will be less likely to be published. Entries and the calendar may be edited for length and content.Friday, Jan. 30Soups of the World to benefit the Bridge Emergency Shelter, 5-7 p.m. at the Montezuma County Annex on North Chestnut. Soups, salad, bread and...


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Brockerhoff Lab research data
Summary The overall goal of research in my laboratory is to understand the biology of the cone photoreceptor and apply this information to dissecting the molecular basis of human retinal disease. We use zebrafish as our model system because they have an abundance of cone photoreceptors and because biological problems can be tackled in zebrafish using many different experimental approaches.
Over several years we have identified zebrafish mutants that have impaired vision because of defects in cone photoreceptor structure/function. Mutations we have characterized previously alter unique aspects of the cone photoreceptor biology such as: phototransduction (nof); synaptic transmission (nrc); metabolism (noa); and cell viability (pob, pde6c).
Currently we have three projects in the lab that are all related to characterizing cell death in the pde6c mutant which lacks cone-specific phosphodiesterase. Without pde6c, cone photoreceptors degenerate soon after their formation. Our studies are aimed at dissecting the molecular triggers responsible for cell death. They take advantage of the clarity and genetic tractability of the zebrafish model system and the existing knowledge of the phototransduction signal cascade.
Projects In the absence of phosphodiesterase, cGMP levels increase. The hypothesis is that increases in cGMP lead to excessive Ca2+ influx through the cGMP-gated cation channel in the outer segment plasma membrane and that this triggers apoptosis of photoreceptors. We are evaluating the spatial and temporal changes in Ca2+ that occur prior and during cell death using genetically encoded Ca2+ indicators and live imaging of zebrafish larvae. A second aspect to this project is to use live imaging to evaluate the formation of reactive oxygen species during cone photoreceptor death.
The second project is to characterize a potential "bystander effect" associated with the death of cone photoreceptors. The most familiar example of the bystander phenomenon in vision is the loss of cones in retinitis pigmentosa, a disease where the mutation is present only in rods. The death of rods leads to a subsequent death of wild type (non-mutation carrying) cones, so-called bystanders. Our general strategy is to make mosaic fish containing mixtures of mutant and non-mutant cones to determine what parameters may influence the death of healthy neighbors in the presence of dying cones. Pharmacological and molecular strategies are being used to evaluate the molecular signals involved in this process. Understanding the spread of cell death from mutant to non-mutant cells is not only important for visual disease but is important in other degenerative diseases as well.
The final project is a genetic screen to identify suppressors of cell death in the pde6c background. The strategy is to use fish that are homozygous for the pde6c mutation and also carry a fluorescent protein specifically expressed in photoreceptors. In this mutant fish strain, the cone photoreceptor mosaic is absent due to massive cone degeneration. Dominant and recessive mutations that rescue the photoreceptor mosaic but not vision will be identified through microscopic evaluation, western blot analysis and visual behavior analysis. This project will produce novel insights into the fundamental processes of cone degeneration.


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Wed, Jun 27, 12 at 19:13
i'm running some alum triplex in pvc conduit so i only need to go 18" deep and wondering if i should leave a gap in the low spots in case water finds it's way into the pvc somehow and collects there. i would protect the gap with a piece of larger pvc slipped over the open space. is this a worth-while idea or something to not worry about? |
Follow-Up Postings:
Underground conduit IS going to fill with water, and unless you have a one way valve, any gap you leave will do as much to allow water to enter as to exit. As long as the insulation is rated for use in a wet location (and ALL underground locations ARE WET) and not damaged the presence of water is not a problem. |
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As cool as the Raptor was when it debuted last year, there wasn't a whole lot to appreciate under the hood. Massive suspension modifications were enough to make the Raptor a hit among the niche set of off-roaders that wants to go fast in the sand but doesn't really want to build their own trucks. If you've never experienced a lifted truck with a properly dialed-in suspension, the Raptor is probably the most amazing truck in the world. But it came with a boat anchor for an engine.
A year later the same truck has an all-new 6.2-liter V-8 rated at 411 hp, an impressive 101 hp increase over the 5.4-liter V-8 offered before. One would imagine this increase in power totally transforms the truck, but that's not quite the case. With a 3-ton curb weight to overcome, the 6.2-liter engine still feels lackadaisical when you floor the gas pedal. Is it better than the 5.4? Certainly. But the 5.4-liter was not very good to start with, and the 6.2 doesn't significantly raise the performance bar for $3000.
Ford has made huge strides with its powertrain offerings in the past few years, in vehicles like the Fusion Hybrid and anything with an EcoBoost V-6. Hopefully the performance vehicles will be treated to worthwhile, modern powerplants soon. I'd love a Raptor that had the engine performance to match its aggressive looks.
- Phil Floraday, Senior Web Editor


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Scott Gessler: Database used to find illegal voters can have "lag time," feds say
Since August, Secretary of State Scott Gessler has been working with the federal government to try and identify voters illegally registered in Colorado in an effort to prevent voter fraud on election day. As of last Friday, 44 voters have been removed. His critics argue that the data he's using is not always accurate or up-to-date -- and officials with the federal agency that maintain these records confirm there can be "lag times" in the data.Scott Gessler
At the center of the controversies around Gessler's anti-fraud initiatives are debates over whether fraud is a serious problem that demands the resources that the Secretary of State has devoted to it. His critics say the effort has become too much of a priority and can confuse or intimidate legal voters.
Gessler has sent two rounds of letters to thousands of registered voters he suspects are not citizens. These are individuals who are registered to vote, but have a record on file with the Division of Motor Vehicles showing that they were at one point an immigrant. From there, Gessler's office was able to cross-check those names with records of a federal database that exist as part of the Systematic Alien Verification for Entitlements Program, or SAVE, which is a part of U.S. Citizenship and Immigration Services. That agency falls under the Department of Homeland Security. Sam Levin Secretary of State Scott Gessler.
Gessler has long sought access to the records of SAVE, a program that essentially verifies immigration status, and his team was finally able to use that information starting in late August. Any registered voter who came up as a citizen through the SAVE checks was sent a letter asking them to verify their citizenship or voluntarily remove themselves from the voter rolls. Their names were also sent to county clerks with instructions on how they can potentially challenge these voters. A first round found 141 potentially illegal voters. And he announced two weeks before election day that his team has identified 300 more.
As of Friday, 44 individuals had been removed from the rolls or were withdrawing as a result of these citizen checks.
The problem, his critics charge, is that there are circumstances in which someone could have become a citizen but still show up as an immigrant in the records maintained by SAVE. That means legal voters are receiving letters asking them to prove their citizenship, they say. In August, after the first round, we spoke with one legal voter originally from South Africa who became a citizen in 2010, but still received the letter. In the second round, we reached another letter recipient who has been a citizen since 2001 -- and also happens to be an immigration advocate.
So why are citizens receiving the non-citizen letter?
Maria Elena Upson, a spokeswoman with the U.S. Citizenship and Immigration Services, or USCIS, tells us that there can be delays in the updating of records maintained by the SAVE program.
We asked her if it's possible that someone might still be listed as an immigrant in the SAVE records even if they have become a citizen. She writes in an e-mail to us, "It is possible if an immigrant was recently naturalized and their record wasn't updated shortly after the change in status. Once an individual naturalizes, the source records need to be updated and there may be some lag time between naturalization and a SAVE check."
Asked for more specifics on the lag times -- and how long they could be -- she writes;
Lag times are dependent on when an individual's updated information is entered into a database accessed by SAVE. Generally, these lag times are not very long but there can be instances where an individual derived citizenship status from his/her parents years ago and it could take longer to confirm. If an individual believes that information returned from the SAVE Program is not current, they can submit additional documentation to help confirm citizenship status.This seems to be the case with the immigration advocate we spoke to two weeks ago and is a scenario we've heard about from other sources.
Continue for comments from one county clerk and response from the Secretary of State's office.
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Mining in Pakistan
Mining is an important industry in Pakistan. Pakistan has deposits of several minerals including coal, copper, gold, chromite, mineral salt, bauxite and several other minerals. There are also a variety of precious and semi-precious minerals that are also mined. These include peridot, aquamarine, topaz, ruby, emerald, rare-earth minerals bastnaesite and xenotime, sphene, tourmaline, and many varieties and types of quartz.[1]
The Pakistan Mineral Development Corporation is the responsible authority for the support and development of the mining industry. Gemstones Corporation of Pakistan looks after the interests of stake holders in gem stone mining and polishing as an official entity. Baluchistan is the richest province in terms of mineral resources available in Pakistan. While recently Sindh discovered coal deposits in Thar. Khyber Pakhtoonkhwa is rich in terms of gems. Most of the mineral gems found in Pakistan exists here. Apart from oil, gas and some mineral used in nuclear energy purposes which comes directly under federal control mining of other minerals is provincial issue. Currently around 52 minerals, are mined and processed in Pakistan.[2]
Coal is found in very large quantities in Thar, Chamalang, Quetta and other sites. Thar reserves are estimated to be 850 Trillion Cubic Feet. There is enough coal in Pakistan's Thar area ( though a part of the coal is not of good quality) that it can be used to generate power for the next 100 years without relying on other power sources i.e. hydro/oil resources. In March 2010, Engro Chemical announced that the group is investing a large amount of money to develop coal fields in Pakistan. The chemical company also announced to establish an energy park in UET Lahore, and start research on In-Situ Coal gasification and high pressure transport gasifiers.[3]
Mineral salt[edit]
Salt has been mined in the region since 320 BC. The Khewra Salt Mines are among the world's oldest and biggest salt mines. Salt is mined at Khewra in an underground area of about 110 square kilometres (42 sq mi). Khewra salt mine has an estimated total of 220 million tonnes of rock salt deposits. The current production from the mine is 325,000 tons of salt per annum.
Copper and gold[edit]
In Reko Diq, Balochistan, deposits of copper and gold are present. Antofagasta, the company which possesses the Reqo Diq field, is targeting an initial production of 170,000 metric tons of copper and 300,000 ounces of gold a year. The project may produce more than 350,000 tons a year of copper and 900,000 ounces of gold.[4] There are also copper deposits in Daht -e- Kuhn, Nokundi, Located in Chaghi district.
Iron ore[edit]
Iron ore is found in various regions of Pakistan including Nokundi, Chinot and the largest one in Kalabagh (Less than 42% quality), Haripur and other Northern Areas.[5]
Gems and other precious stones[edit]
A number of precious stones are mined and polished for local as well as export purposes. The centre point of this operation is Khyber-Pakhtoonkhwa. These include actinolite, hessonite, rodingite, agate, idocrase, rutile, aquamarine, jadeite, ruby, amazonite, kunzite, serpentine, azurite, kyanite, spessartine (garnet), beryl, marganite, spinel, emerald, moonstone, topaz, epidote, pargasite, tourmaline, garnet (alamandine), peridot, turquoise, grossular, quartz (citrine & others) and vesuvianite. The export earned from these gems is more than 200 Million dollars.[6]
Accidents in mining[edit]
Mining in Pakistan is a dangerous job, especially coal mining, as safety procedures are often neglected and accidents are quite common.[7][8]
- On 21 March 2011 at least 45 miners died due to an explosion in a coal mine in Surran range, some 35 km (22 mi) east of the provincial capital, Quetta.[9]
- On 14 of February 2011, 2 Chinese engineers died in a chromite mine collapse in Qila Saifullah, Pakistan [10]
- On 27 May 2004, 15 miners died after a gas explosion at a coal mine in Balochistan.[11]
See also[edit]
- ^ http://www.palagems.com/pakistanoverview.htm
- ^ http://www.mbendi.com/indy/ming/as/pk/p0005.htm
- ^ http://www.nation.com.pk/pakistan-news-newspaper-daily-english-online/Business/27-Mar-2010/Engro-Chem-to-invest-on-Thar-coal-development
- ^ http://www.bloomberg.com/apps/news?pid=21072065&refer=conews&tkr=ABX:US&sid=a5Tg_KsLeCxM
- ^ http://www.mbendi.com/indy/ming/iron/as/pk/p0005.htm
- ^ http://www.gsp.gov.pk/resources/gems.html
- ^ "Death In The Mines"
- ^ Pakistani Manifestation Condemns Deadly Mine Accident, Inaction in Retrieving the Dead
- ^ "52 Miners Trapped After a Coal Mine Accident in Pakistan
- ^ 2 Chinese engineers die in Pakistan mine collapse
- ^ "Fifteen die in Pakistan coal mine blast"
External links[edit]


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Sat, Feb 1, 14 at 8:21
Follow-Up Postings:
That is lovely! It would make a nice birthday gift for Lilo, especially with the droplets of water on the flower and the leaves. |
- Posted by anneliese_32 6 (My Page) on Sat, Feb 1, 14 at 10:38
Beautiful. For some reason garden irises don't do well in my garden, but I have two batches of crested dwarf irises which around here grow in the wild. |
- Posted by lilosophie (My Page) on Sat, Feb 1, 14 at 11:36
I have one similar to this, it always makes me happy when it appears |
- Posted by west_gardener (My Page) on Sat, Feb 1, 14 at 14:41
Just beautiful. |
It is a beauty. We have a similar one named "Pink Jabot". One of Georges favorites but he can never remember what a jabot is. |
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text: So...I yell at the coach on the other soccer team for standing in the Goal Box the whole time,Our girls would not kick the ball at an adult b/c they have NEVER HAD this happen to them before. I have a couple of the parents from our team look down their noses at me for doing so. Shut the FUCK up and look down your nose at someone that wont break it, cus Iam about to do so! You are not GOD!!


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Track Information
Devil's Bowl Speedway
Physical/GPS Address: 2743 Route 22A, West Haven, VT 05743
Office/Mailing Addesss: 261 Randbury Road, Rutland, VT 05701
Phone: (802) 265-3112
Fax: (802) 773-0147
Conveniently located on Route 22A in West Haven, Vermont, 4.6 miles north of Exit 2 off U.S. Route 4.
Racing every Friday night at 7:00 p.m.
Bond Auto Parts Modifieds
Late Models
Central Vermont Motorcycles Mini Stocks
SK Light Modifieds
Special Events:
American-Canadian Tour Late Models
Vermont State Late Model Championship Series
Northern Modified Challenge Series
Kart Series & Mini Cup Series
North East Mini Stock Tour
New England Antique Racers
Devil's Bowl Speedway Enduro Series
Daredevil "community" racing division
Sports Car Club of Vermont
Devil's Bowl Speedway has long been known as "Vermont's Fastest Half-Mile." The track was built by C.J. Richards and opened in 1967. Devil's Bowl Speedway has seen several transformations during its lifespan; it was dirt for its first four seasons before being paved in 1971. The dirt surface returned in 1975, and the track was again paved in 2010, complete with progressive banking in the corners. A new era for the track began in 2012 under the leadership of new owners Mike & Alayne Bruno; Mike Bruno was a second-generation Devil's Bowl Speedway competitor for 25 years.
The 2014 schedule features 15 asphalt race dates sanctioned by the NASCAR Whelen All-American Series, with four weekly racing divisions – open-wheel, dirt-style Modifieds; American-Canadian Tour-type Late Models; eight-cylinder Renegades; and four-cylinder Mini Stocks. Devil's Bowl Speedway has also has created a new Kart Series for aspiring young drivers to test their skills on a new paved infield track.
New for 2014, the dirt surface will return for a highly anticipated three-event series in September and October, with a full-time return to asphalt racing the spring of 2015.


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What Are Stem Cells? (Released December 2004)
Koegler, Gesine; Sensken, Sandra; Airey, Judith A; Trapp, Thorsten; Mueschen, Markus; Feldhahn, Niklas; Liedtke, Stefanie; Sorg, Ruediger V; Fischer, Johannes; Rosenbaum, Claudia; Greschat, Susanne; Knipper, Andreas; Bender, Joerg; Degistirici, Oezer; Gao, Jizong; Caplan, Arnold I; Colletti, Evan J; Almeida-Porada, Graca; Mueller, Hans W; Zanjani, Esmail; Wernet, Peter
Journal of Experimental Medicine [J. Exp. Med.]. Vol. 200, no. 2, pp. 123-135. 19 Jul 2004.
Here a new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described. This rare population grows adherently and can be expanded to 10 super(15) cells without losing pluripotency. In vitro USSCs showed homogeneous differentiation into osteoblasts, chondroblasts, adipocytes, and hematopoietic and neural cells including astrocytes and neurons that express neurofilament, sodium channel protein, and various neurotransmitter phenotypes. Stereotactic implantation of USSCs into intact adult rat brain revealed that human Tau-positive cells persisted for up to 3 mo and showed migratory activity and a typical neuron-like morphology. In vivo differentiation of USSCs along mesodermal and endodermal pathways was demonstrated in animal models. Bony reconstitution was observed after transplantation of USSC-loaded calcium phosphate cylinders in nude rat femurs. Chondrogenesis occurred after transplanting cell-loaded gelfoam sponges into nude mice. Transplantation of USSCs in a noninjury model, the preimmune fetal sheep, resulted in up to 5% human hematopoietic engraftment. More than 20% albumin-producing human parenchymal hepatic cells with absence of cell fusion and substantial numbers of human cardiomyocytes in both atria and ventricles of the sheep heart were detected many months after USSC transplantation. No tumor formation was observed in any of these animals.
Rice, CM; Scolding, NJ*
Lancet [Lancet]. Vol. 364, no. 9429, pp. 193-199. 0-16 Jul 2004.
Much excitement has surrounded recent breakthroughs in embryonic stem-cell research. Of lower profile, but no less exciting, are the advances in the field of adult stem-cell research, and their implications for cell therapy. Clinical experience from use of adult haemopoietic stem cells in haematology will facilitate and hasten transition from laboratory to clinic - indeed, clinical trials using adult human stem cells are already in progress in some disease states, including myocardial ischaemia. Here, with particular reference to neurology, we review processes that might underlie apparent changes in adult cell phenotype. We discuss implications these processes might have for the development of new therapeutic strategies using adult stem cells.
Pochampally, RR; Neville, BT; Schwarz, EJ; Li, MM; Prockop, DJ
Proceedings of the National Academy of Sciences, USA [Proc. Natl. Acad. Sci. USA]. Vol. 101, no. 25, pp. 9282-9285. 22 Jun 2004.
Cell fusion was recently reported to account for the plasticity of adult stem cells in vivo. Adult stem cells, referred to as mesenchymal stem cells or marrow stromal cells, from rat marrow, were infused into 1.5- to 2-day-old chick embryos. After 4 days, the rat cells had expanded 1.3- to 33-fold in one- third of surviving embryos. The cells engrafted into many tissues, and no multinuclear cells were detected. The most common site of engraftment was the heart, apparently because the cells were infused just above the dorsal aorta. Some of the cells in the heart expressed cardiotin, and alpha -heavy-chain myosin. GFP super(+) cells reisolated from the embryos had a rat karyotype. Therefore, the cells engrafted and partially differentiated without evidence of cell fusion.
Dor, Yuval; Brown, Juliana; Martinez, Olga I; Melton, Douglas A
Nature [Nature]. Vol. 429, no. 6987, pp. 41-46. 6 May 2004.
How tissues generate and maintain the correct number of cells is a fundamental problem in biology. In principle, tissue turnover can occur by the differentiation of stem cells, as is well documented for blood, skin and intestine, or by the duplication of existing differentiated cells. Recent work on adult stem cells has highlighted their potential contribution to organ maintenance and repair. However, the extent to which stem cells actually participate in these processes in vivo is not clear. Here we introduce a method for genetic lineage tracing to determine the contribution of stem cells to a tissue of interest. We focus on pancreatic beta -cells, whose postnatal origins remain controversial. Our analysis shows that pre-existing beta -cells, rather than pluripotent stem cells, are the major source of new beta -cells during adult life and after pancreatectomy in mice. These results suggest that terminally differentiated beta -cells retain a significant proliferative capacity in vivo and cast doubt on the idea that adult stem cells have a significant role in beta -cell replenishment.
Wagers, AJ; Weissman, IL
Cell [Cell]. Vol. 116, no. 5, pp. 639-648. Mar 2004.
Recent years have seen much excitement over the possibility that adult mammalian stem cells may be capable of differentiating across tissue lineage boundaries, and as such may represent novel, accessible, and very versatile effectors of therapeutic tissue regeneration. Yet studies proposing such 'plasticity' of adult somatic stem cells remain controversial, and in general, existing evidence suggests that in vivo such unexpected transformations are exceedingly rare and in some cases can be accounted for by equally unexpected alternative explanations.
Matsuura, K; Nagai, T; Nishigaki, N; Oyama, T; Nishi, J; Wada, H; Sano, M; Toko, H; Akazawa, H; Sato, T; Nakaya, H; Kasanuki, H; Komuro, I
Journal of Biological Chemistry [J. Biol. Chem.]. Vol. 279, no. 12, pp. 11384-11391. 19 Mar 2004.
Although somatic stem cells have been reported to exist in various adult organs, there have been few reports concerning stem cells in the heart. We here demonstrate that Sca-1-positive (Sca-1+) cells in adult hearts have some of the features of stem cells. Sca-1+ cells were isolated from adult murine hearts by a magnetic cell sorting system and cultured on gelatin-coated dishes. A fraction of Sca-1+ cells stuck to the culture dish and proliferated slowly. When treated with oxytocin, Sca-1+ cells expressed genes of cardiac transcription factors and contractile proteins and showed sarcomeric structure and spontaneous beating. Isoproterenol treatment increased the beating rate, which was accompanied by the intracellular Ca super(2+) transients. The cardiac Sca-1+ cells expressed oxytocin receptor mRNA, and the expression was up-regulated after oxytocin treatment. Some of the Sca-1+ cells expressed alkaline phosphatase after osteogenic induction and were stained with Oil-Red O after adipogenic induction. These results suggest that Sca-1+ cells in the adult murine heart have potential as stem cells and may contribute to the regeneration of injured hearts.
Sekiya, I; Larson, BL; Vuoristo, JT; Cui, J-G; Prockop, DJ
Journal of Bone and Mineral Research [J. Bone Miner. Res.]. Vol. 19, no. 2, pp. 256-264. Feb 2004.
We assayed gene expressions during adipogenesis of human MSCs. Microarray assays demonstrated time-dependent increases in expression of 67 genes, including 2 genes for transcription factors that were not previously shown to be expressed during adipogenesis. Introduction: Increased numbers of bone marrow adipocytes have been observed in patients with osteoporosis and aplastic anemia, but the pathological mechanisms remain unknown. Recently, microarray assays for mRNAs were used to follow adipogenic differentiation of the preadipocytic cell line, 3T3-L1, but adipogenic differentiation has not been examined in primary cells from bone marrow. Here we defined the sequence of gene expression during the adipogenesis ex vivo of human cells from bone marrow referred to as either mesenchymal stem cells or marrow stromal cells (MSCs). Materials and Methods: MSCs were plated at extremely low densities to generate single-cell derived colonies, and adipogenic differentiation of the colonies assayed by accumulation of fat vacuoles, time-lapse photomicroscopy, microarrays, and reverse transcriptase-polymerase chain reaction (RT-PCR) assays. Results and Conclusions: About 30% of the colonies differentiated to adipocytes in 14 days and about 60% in 21 days. Cell proliferation was inhibited by approximately 50% in adipogenic medium. The differentiation occurred primarily at the center of the colonies, and a few adipocytes that formed near the periphery migrated toward the centers. RT-PCR assays demonstrated that the differentiation was accompanied by increases in a series of genes previously shown to increase with adipogenic differentiation: peroxisome proliferator activated receptor gamma , CCAAT enhancer-binding protein alpha , acylCoA synthetase, lipoprotein lipase, and fatty acid binding protein 4. We also followed differentiation with microarray assays. Sixty-seven genes increased more than 10-fold at day 1 and 20-fold at day 7, 14, or 21. Many of the genes identified were previously shown to be expressed during adipocytic differentiation. However, others, such as zinc finger E-box binding protein and zinc finger protein 145, were not. This study should serve as a basis for future study to clarify the mechanisms of adipocyte differentiation of MSCs.
Alonso, L; Fuchs, E
Genes & Development [Genes Dev.]. Vol. 17, no. 10, pp. 1189-1200. 15 May 2003.
Although it seems unlikely that adult stem cells harvested from one tissue might be reprogrammed to take on the characteristics of a different cell type, several tantalizing results have encouraged researchers to consider this possibility. Before scientists can begin to define the limits of adult stem cell plasticity, they need to understand the signals that instruct multipotent cells to self-renew and differentiate within the lineages of their resident tissues. Skin is an excellent model system in which to explore these fundamental mechanisms, because skin keratinocytes are easily accessible and are one of the few adult stem cell types that can be maintained and propagated in vitro. These cells have already been engrafted long term to replace damaged epidermis on burn patients. Now skin biologists have begun to identify some of the key steps involved in generating a functional tissue from multipotent stem cells.
Lee, H-S; Crane, GG; Merok, JR; Tunstead, JR; Hatch, NL; Panchalingam, K; Powers, MJ; Griffith, LG; Sherley, JL*
Biotechnology and Bioengineering [Biotechnol. Bioeng.]. Vol. 83, no. 7, pp. 760-771. 2003.
Adult stem cells have potential use for several biomedical applications, including cell replacement therapy, gene therapy, and tissue engineering. However, such applications have been limited due to difficulties encountered in expanding functional adult stem cells. We have developed a new approach to the problem of adult stem cell expansion based on the suppression of asymmetric cell kinetics (SACK). We postulated that asymmetric cell kinetics, required for adult stem cell function, were a major barrier to their expansion in culture. As such, conversion of adult stem cells from asymmetric cell kinetics to symmetric cell kinetics would promote their exponential expansion and longterm propagation in culture. The purine nucleoside xanthosine (Xs), which promotes guanine ribonucleotide biosynthesis, can be used to reversibly convert cells from asymmetric cell kinetics to symmetric cell kinetics. We used Xs supplementation to derive clonal epithelial cell lines from adult rat liver that have properties of adult hepatic stem cells. The properties of two Xs-derived cell lines, Lig-8 and Lig-13, are described in detail and compared to properties of adult rat hepatic cell lines derived without Xs supplementation. The Xs-derived cell lines exhibit Xs-dependent asymmetric cell kinetics and Xs-dependent expression of mature hepatic differentiation markers. Interestingly, Lig-8 cells produce progeny with properties consistent with hepatocyte differentiation, while Lig-13 progeny cells have properties consistent with bile duct epithelium differentiation. A stable adult cholangiocyte stem cell line has not been previously described. Consistent with the principles of their derivation, the SACK-derived hepatic cell lines exhibit neither senescence nor tumorigenic properties, and their differentiation properties are stable after longterm culture. These characteristics of SACK-derived stem cell lines underscore asymmetric cell kinetics as an essential adult stem cell property with potential to be the basis for a general approach to expansion and propagation of diverse adult stem cells.
Ramalho-Santos, M; Yoon, S; Matsuzaki, Y; Mulligan, RC; Melton, DA*
Science (Washington) [Science (Wash.)]. Vol. 298, no. 5593, pp. 597-600. 18 Oct 2002.
The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in the genome. When compared to differentiated cell types, stem cells express a significantly higher number of genes (represented by expressed sequence tags) whose functions are unknown. Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology.
Avots, A; Harder, F; Schmittwolf, C; Petrovic, S; Mueller, AM
Immunological Reviews [Immunol. Rev.]. Vol. 187, pp. 9-21. Sep 2002.
Stem cell systems represent an effective and powerful approach for tissue development and regeneration of diverse tissue types. Common and defining features of these exceptional cells are the capacity for self-renewal and the potential for differentiation into multiple mature cell types. Recently, surprising new observations have indicated that stem cells isolated from one adult tissue can also give rise to mature cells of other cell lineages, irrespective of classical germ layer designations. This discovery has resulted in quantum leaps in both scientific knowledge and the potential applications of stem cells. The new findings contradict central dogmas of commitment and differentiation of stem and progenitor cells. However, the true potential of somatic stem cells is just emerging and the new findings have to be defined more fully and integrated into a unifying model of stem cell potential and behavior. Here we analyze the developmental potential of hematopoietic stem cells of mouse and man following their injection into the murine preimplantation blastocyst, an environment that allows the development of all cell lineages. In addition, we discuss the emerging lines of evidence of the developmental plasticity of hematopoietic and other somatic stem cells and consider how cellular memory of transcriptional states is established and may be potentially involved in this phenomenon.


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YOSEMITE NATIONAL PARK, Calif., April 3, 2012 – Delaware North Companies (DNC) Parks & Resorts at Yosemite President Dan Jensen led a community event and ribbon cutting ceremony today, April 3, to celebrate the completion of a $1.15 million dollar eco-friendly remodel of the Village Store, which serves millions of park visitors annually. Attendees joining Jensen in the celebration include Yosemite National Park Superintendent Don Neubacher, Tom Willey with T&D Willey Farms, Yosemite Valley students, Yosemite National Park visitors and community members. The event dedicated the newly refurbished store highlighting its 25 percent energy use reduction, sustainable design features and locally grown organic produce. This is one of the many ways DNC supports the National Park Service's Healthy Parks, Healthy People initiative.
Eco-Friendly Renovation Highlights Include:
· New energy-efficient refrigeration - equivalent of removing between 8-10 vehicles off the road yearly
· Marmoleum flooring incorporated in the store is made with 97% of natural raw materials, 70% of which are rapidly renewable, along with a 40% recycled content. Marmoleum is biodegradable and can be fully recycled
· Eco-friendly paint
· Energy-efficient light fixtures were installed that are California Title 24 compliant
· Produce moved upfront to promote healthier options to visitors and organic offerings were enhanced
· New retail displays and grocery shelving - previous displays and shelving were repurposed for Curry Village and Yosemite Lodge at the Falls, which resulted in less renovation waste to the landfill
· Upgraded store ventilation system, and DNC added R-19 batt insulation to reduce the need to heat and cool air
· Reclaimed lighting from the store was installed in the backroom areas to improve lighting
· DNC partnered with NPS to install a new cooling tower featuring a closed recirculating loop to cool refrigeration units - saving 2,500 gallons of water per day and nearly 913,000 gallons of water a year
"The Village Store remodel was a collaborative effort focusing on healthy options for Yosemite visitors and eco-friendly materials used in the design," said DNC Parks & Resorts at Yosemite President Dan Jensen. "We are committed to taking great care of our guests and the environment, which is why this project is so meaningful to us."
About Delaware North Companies Parks & Resorts
Delaware North Companies Parks & Resorts is an industry leader providing Stewardship and Hospitality in Special Places SM, with hotel, retail, food service, recreation and transportation operations at historic and scenic properties in North America and Australia. The company operates Kennedy Space Center Visitor Complex and in Yellowstone, Grand Canyon, Sequoia and Yosemite national parks, including The Ahwahnee and other Yosemite lodges; Tenaya Lodge at Yosemite & the Cottages at Tenaya Lodge; Harrison Hot Springs Resort & Spa in British Columbia; Niagara Falls State Park; The Lodge at Geneva-on-the-Lake in Ohio; Gideon Putnam Resort in Saratoga; Holiday Inn West Yellowstone, Gray Wolf Inn & Suites and Yellowstone Park Hotel. The company also owns and operates five luxury resorts in Australia: Lizard Island Resort, Heron Island Resort, Wilson Island Resort, Kings Canyon Resort and El Questro Homestead and Wilderness Park. To learn more about Delaware North Companies' hospitality management expertise, visit www.experiencednc.com.
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Editor's Note: Additional photos of the Village Store remodel celebration are available by emailing email@example.com


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Wow, this is so awesome of Martina McBride.
Martina took to her blog on Sunday to let fans know about her family's plans for this summer which includes heading to Los Angeles for a few weeks so that her daughter can pursue her acting dream.
From Martina's blog...
Hey everybody
Our family is getting ready to embark on a great adventure and I wanted to share it with all of you. We are moving to Los Angeles for the next few weeks! My middle daughter, Emma, has always wanted to try her hand at acting and so we have enrolled her in a couple of acting classes and workshops in LA this month so that she can see if it's something she wants to pursue.This could be the beginning of realizing her dream, which is a beautiful thing. I know how supportive my parents were at her age and how they did everything possible to help me be able to sing wherever and whenever I could and I'm happy we can do the same for her.
We just landed not long ago and got to check out the house we are renting while we are here. We love it! We are also excited about the food, the shopping, and the glorious weather. Especially the food and the shopping!
I am also working some while we are thre and I'm excited about being a part of the show Opening Act for E! Channel. It debuts Monday night, July 9, at 10/9 Central on E! I think it's a really cool show and idea. I love being part of making someone's dreams come true!
Anyway, I just wanted to share our latest news with you. The idea of picking up and moving somewhere new is kind of crazy and kind of amazing! will be tweeting and updating you on how everything is going over the next month so you can share in our journey. I have a feeling something really magical is going to happen, not only for Emma, but for all of us.
Stay tuned....
What a wonderful thing to be able to do for your kid. If my mom had been able to do this for me when I was a kid, I might have become the mime I know I was always meant to be.