text:
Abstract: | Background: Recent publications on YouTube have advocated its potential for patient education. However, a reliable description of what could be considered quality information for patient education on YouTube is missing. Objective: To identify topics associated with the concept of quality information for patient education on YouTube in the scientific literature. Methods: A literature review was performed in MEDLINE, ISI Web of Knowledge, Scopus, and PsychINFO. Abstract selection was first conducted by two independent reviewers; discrepancies were discussed in a second abstract review with two additional independent reviewers. Full text of selected papers were analyzed looking for concepts, definitions, and topics used by its authors that focused on the quality of information on YouTube for patient education. Results: In total, 456 abstracts were extracted and 13 papers meeting eligibility criteria were analyzed. Concepts identified related to quality of information for patient education are categorized as expert-driven, popularity-driven, or heuristic-driven measures. These include (in descending order): (1) quality of content in 10/13 (77%), (2) view count in 9/13 (69%), (3) health professional opinion in 8/13 (62%), (4) adequate length or duration in 6/13 (46%), (5) public ratings in 5/13 (39%), (6) adequate title, tags, and description in 5/13 (39%), (7) good description or a comprehensive narrative in 4/13 (31%), (8) evidence-based practices included in video in 4/13 (31%), (9) suitability as a teaching tool in 4/13 (31%), (10) technical quality in 4/13 (31%), (11) credentials provided in video in 4/13 (31%), (12) enough amount of content to identify its objective in 3/13 (23%), and (13) viewership share in 2/13 (15%). Conclusions: Our review confirms that the current topics linked to quality of information for patient education on YouTube are unclear and not standardized. Although expert-driven, popularity-driven, or heuristic-driven measures are used as proxies to estimate the quality of video information, caution should be applied when using YouTube for health promotion and patient educational material. |
URI: | http://hdl.handle.net/10037/6675 |
Abstract: | Introduction: Helicopter emergency medical services (HEMS) aim to bring highly specialised crews to the major incident for triage, treatment and transport. When the site is difficult to access, HEMS may be the only mode of transportation of both personnel and patients. This systematic review will identify, describe and appraise literature regarding the role of HEMS in medical response to major incidents. We aim to improve knowledge on HEMS role in a major incident and provide a basis for future research. Methods and analysis: A systematic literature review will be conducted with search phrases that combine HEMS and major incidents to identify when and how HEMS have been used. Included literature will be subject to quality appraisal and data extraction. Ethics: No ethical approval is sought because this is a literature review. It will be submitted to a peer-reviewed journal and the PRISMA guidelines will be followed. |
URI: | http://hdl.handle.net/10037/6016 |
Abstract: | Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration in the general middle-aged population. A total of 1,560 individuals, aged 50–62 years without diabetes, were included in the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6). GFR was measured as single-sample plasma iohexol clearance. Hyperfiltration was defined as GFR >90th percentile, adjusted for sex, age, weight, height, and use of renin-angiotensin system inhibitors. Participants with IFG had a multivariable-adjusted odds ratio of 1.56 (95% CI 1.07–2.25) for hyperfiltration compared with individuals with normal fasting glucose. Odds ratios (95% CI) of hyperfiltration calculated for a 1-unit increase in fasting plasma glucose (FPG) and HbA1c, after multivariable-adjustment, were 1.97 (1.36–2.85) and 2.23 (1.30–3.86). There was no association between fasting insulin levels and hyperfiltration. A nonlinear association between FPG and GFR was observed (df = 3, P < 0.0001). GFR increased with higher glucose levels, with a steeper slope beginning at FPG ≥5.4 mmol/L. Borderline hyperglycemia was associated with hyperfiltration, whereas hyperinsulinemia was not. Longitudinal studies are needed to investigate whether the hyperfiltration associated with IFG is a risk factor for renal injury in the general population. |
URI: | http://hdl.handle.net/10037/4113 |
Abstract: | Background: Atrial fibrillation (AF) is associated with increased mortality and morbidity, including risk for cerebral macro- and microinfarctions and cognitive decline, even in the presence of adequate oral anticoagulation. AF is strongly related to increased inflammatory activity whereby anti-inflammatory agents can reduce the risk of new or recurrent AF. However, it is not known whether anti-inflammatory therapy can also modify the deterioration of neurocognitive function in older patients with AF. In the present study, older patients with AF were treated with intensive lipid-lowering therapy with atorvastatin 40 mg and ezetimibe 10 mg, or placebo. We examined the relationship between neurocognitive functions and inflammatory burden. Findings: Analysis of inflammatory markers revealed significant reductions in high sensitivity C-reactive protein (hs-CRP), fibroblast growth factor (FGF), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 receptor antagonist (IL-1RA), interleukin (IL)-9, IL-13 and IL-17, and interferon-γ (IFNγ) in the treatment group compared to placebo. Reduction in plasma concentration of IL-1RA, IL-2, IL-9 and IL-12, and macrophage inflammatory protein-1β (MIP-1β) correlated significantly with improvement in the neurocognitive functions memory and speed. Loss of volume in amygdala and hippocampus, as determined by magnetic resonance imaging (MRI), was reduced in the treatment arm, statistically significant for left amygdala. Conclusions: Anti-inflammatory therapy through intensive lipid-lowering treatment with atorvastatin 40 mg and ezetimibe 10 mg can modify the deterioration of neurocognitive function, and the loss of volume in certain cerebral areas in older patients with AF. |
URI: | http://hdl.handle.net/10037/6020 |
Abstract: | Background: In three previous Norwegian studies conducted between 1974 and 1993, the annual
incidence rates of hospital admitted head injuries were 236, 200 and 169 per 100,000 population.
The aim of this study was to describe the incidence of head injury in the Stavanger region and to
compare it with previous Norwegian studies.
Methods: All head injured patients referred to Stavanger University Hospital during a one-year period (2003) were registered in a partly prospective and partly retrospective study. The catchment area for the hospital is strictly defined to a local population of 283,317 inhabitants (2003). Results: The annual incidence rate was 207/100,000 population for hospital referred head injury and 157/100,000 population for hospital admitted head injury. High age- and sex specific incidence rates were observed among the oldest, and the highest rate (882/100,000) among men above 90 years. More than 50% of the injuries were caused by falls. Conclusion: Comparison with previous Norwegian studies indicates decreasing annual incidence rates for hospital admitted head injury during the last 30 years. |
URI: | http://hdl.handle.net/10037/2194 |
Abstract: | Objective To compare the incidence of obstetric anal sphincter injuries (OASIS) in two time periods, before and after implementing a training programme for improved perineal support aimed at reducing the incidence of obstetric anal sphincter injuries. The secondary aim was to study incidence of obstetric anal sphincter injuries in subgroups defined by risk factors for OASIS. Design Population-based cohort study. Setting University hospital setting in Oslo, Norway. Participants Two cohorts of all delivering women in the largest hospital in Norway during two time periods (2003–2005 and 2008–2010) were studied. After excluding caesarean sections and preterm deliveries (< week 32), the study population consisted of 31 709 deliveries, among which 907 women were identified with obstetric anal sphincter injury. Primary and secondary outcome measures Incidence of OASIS in two time periods. Maternal, obstetrical and foetal risk factors for OASIS were collected from the hospital obstetric database. Univariate analyses and multivariate logistic regression analyses, presenting adjusted ODs for OASIS, were performed. Results The OASIS incidence was significantly reduced by 50%, from 4% (591/14787) in the first time period to 1.9% (316/16 922) in the second. This reduction could not be explained by changes in population characteristics or OASIS risk factors during the study years. The reduction of incidence of OASIS between the two study periods was consistent across subgroups of women; regardless of parity, delivery method and infant birth weight. Conclusions A marked reduction in the incidence of OASIS was observed in all studied subgroups of women after implementing the training programme for perineal protection. Further, this reduction could not be explained by the differences in patient characteristics across the study period. These findings indicate that the training programme with improved perineal protection markedly reduced the risk of OASIS. |
URI: | http://hdl.handle.net/10037/4938 |
Abstract: | In acute respiratory distress syndrome (ARDS) the recruitment maneuver (RM) is used to reexpand atelectatic areas of the lungs aiming to improve arterial oxygenation. The goal of our paper was to evaluate the response to RM, as assessed by measurements of extravascular lung water index (EVLWI) in ARDS patients. Materials and Methods. Seventeen adult ARDS patients were enrolled into a prospective study. Patients received protective ventilation. The RM was performed by applying a continuous positive airway pressure of 40 cm H2O for 40sec. The efficacy of the RM was assessed 5 min later. Patients were identified as responders if PaO2/FiO2 increased by >20% above the baseline. EVLWI was assessed by transpulmonary thermodilution before the RM, and patients were divided into groups of low EVLWI (<10 mL/kg) and high EVLWI (≥10 mL/kg). EVLWI was increased in 12 patients. Following RM, PaO2/FiO2 increased by 33 (4–65) % in the patients with low EVLWI, whereas those in the high EVLWI group experienced a change by only −1((−13)–(+5)) % (P = 0.035). Conclusion. In ARDS, the response to a recruitment maneuver might be related to the severity of pulmonary edema. In patients with incresed EVLWI, the recruitment maneuver is less effective. |
URI: | http://hdl.handle.net/10037/4927 |
Abstract: | Objectives. To determine whether increased levels of B-cell activating factor (BAFF) in patients with SLE are due to disease activity or genetic variations in the promoter region of the BAFF gene and BAFF gene expression. Methods. The case-control study included 101 SLE patients and 111 healthy controls. Five single nucleotide polymorphisms (SNPs) in the BAFF promoter region were investigated by melting point analysis: c.-2841 (T > C), c.-2704 (T > C), c.-2701 (A > T), c.-871 (C > T) and c.-514 (A > G). BAFF mRNA levels were determined by real-time PCR (BAFF-RQ) and serum BAFF (s-BAFF) levels were measured by ELISA. Independent predictors that might be correlated with increased s-BAFF in SLE patients were analysed by multivariate regression methods. Results. Although s-BAFF levels were increased in SLE patients (1.73 vs 0.98 ng/μl, P < 0.001), no specific BAFF genotype was found to associate with SLE. The different genotypes defined by the investigated SNPs were identified both in SLE patients and healthy controls with similar frequencies. No association was found between BAFF genotype and BAFF-RQ. s-BAFF was independent of other factors, correlated with CRP (β = 0.40, P < 0.001) and physician's visual analogue score (R = 0.21, P = 0.046) and inversely with haemoglobin (β = -0.32, P < 0.001) and IgA (β = -0.33, P = 0.001). Conclusions. Increased s-BAFF levels in SLE patients are associated with the acute-phase responses, CRP and haemoglobin, but probably not dependent on BAFF genotype or expression. This indicates that s-BAFF production occurs at sites of inflammation. |
Description: | This article is part of Gro Østli Eilertsen's doctoral thesis. Available in Munin at http://hdl.handle.net/10037/3594 |
URI: | http://hdl.handle.net/10037/3837 |
Abstract: | Background: Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased
sinusoidal flow per se and hence the shear-stress stimulus on the endothelial surface within the liver remnant which is the main stimulus to regeneration. In order to test this hypothesis we wanted to increase the sinusoidal flow without performing a concomitant liver resection. Accordingly, we constructed an aorto-portal shunt to the
left portal vein branch creating a standardized four-fold increase in flow to segments II, III and IV. The impact of
this manipulation was studied in both an acute model (6 animals, 9 hours) using a global porcine cDNA microarray
chip and in a chronic model observing weight and histological changes (7 animals, 3 weeks).
Results: Gene expression profiling from the shunted segments does not suggest that increased sinusoidal flow per se results in activation of genes promoting mitosis. Hyperperfusion over three weeks results in the whole liver gaining a supranormal weight of 3.9% of the total body weight (versus the normal 2.5%). Contrary to our hypothesis, the weight gain was observed on the non-shunted side without an increase in sinusoidal flow. Conclusions: An isolated increase in sinusoidal flow does not have the same genetic, microscopic or macroscopic impact on the liver as that seen in the liver remnant after partial hepatectomy, indicating that increased sinusoidal flow may not be a sufficient stimulus in itself for the initiation of liver regeneration. |
Description: | This article is part of Kim Erlend Mortensen's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/2893 |
URI: | http://hdl.handle.net/10037/2895 |
Abstract: | Objective: Atherosclerosis is a chronic inflammatory disorder that involves a range of inflammatory mediators. Although interleukin (IL)-9 has been related to inflammation, there are at present no data on its role in atherosclerosis. Here we have examined IL-9 and IL-9 receptor (IL-9R) systemically and locally in patients with coronary and carotid atherosclerosis. Methods: Plasma IL-9 was quantified by enzyme immunoassay and multiplex technology. IL-9 and IL-9R mRNA were quantified by real-time RT-PCR, and their localization within the lesion was assessed by immunohistochemistry. Results: The main findings were: (i) Patients with carotid atherosclerosis had significantly raised IL-9 plasma levels compared with healthy controls (n = 28), with no differences between asymptomatic (n = 56) and symptomatic (n = 88) patients. (ii) On admission, patients with acute ST-elevation myocardial infarction (STEMI) (n = 42) had markedly raised IL-9 plasma levels which gradually declined during the first week post-MI. (iii) T cells and monocytes from patients with unstable angina (n = 17) had increased mRNA levels of IL-9 as compared with controls (n = 11). (iv) Carotid plaques (n = 68) showed increased mRNA levels of IL-9 and IL-9R compared to non-atherosclerotic vessels (n = 10). Co-localization to T cells (IL-9 and IL-9R) and macrophages (IL-9) were shown by immunohistochemistry. (v) IL-9 increased IL-17 release in peripheral blood mononuclear cells from patients with unstable angina (n = 5) and healthy controls (n = 5) with a particularly enhancing effect in cells from the patient group. Conclusion: Our findings show increased IL-9 levels in different atherosclerotic disorders both systemically and within the lesion, suggesting a role for the IL-9/IL-9R axis in the atherosclerotic process, potentially involving IL-17 mediated mechanisms. However, the functional consequences of these findings should be further investigated. |
URI: | http://hdl.handle.net/10037/6004 |
Abstract: | Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression with VEGF-A in nonsmall cell lung cancer (NSCLC) patients. Tumor tissue samples from 335 resected stage I to IIIA NSCLC patients were obtained and tissue microarrays (TMAs) were constructed with 4 cores from each tumor specimen. VEGF-A expression was evaluated by immunohistochemistry, and in situ hybridization was used to evaluate the expression of miR-126. In the total material, miR-126 was a significant negative prognostic factor in both univariate (P = .005) and multivariate analyses (hazard ratio [HR] 1.8, 95% confidence interval [CI] 1.2-2.8, P = .01). Stratified by histology, miR-126 was only significant in squamous cell carcinomas (univariate: P < .001; multivariate: HR 3.1, CI 95% 1.7-5.6, P<.001). Stratified by lymph node status, miR-126 was significant only in the lymph node-positive subgroup (univariate: P<.001; multivariate: HR 4.1, CI 95% 2.0-8.4, P < .001). High miR-126 expression correlated significantly with high VEGF-A expression (P = .037). The co-expression of miR-126 and VEGF-A had a significant prognostic impact (P = .002), with 5-year survival rates of 68%, 51%, and 42% for low/low (n = 150), mixed combinations (n = 129), and high/high (n = 35) expression, respectively. miR-126 is a strong and independent negative prognostic factor in NSCLC, and its prognostic impact appears related primarily to histology and nodal status. Cancer 2011. © 2011 American Cancer Society. |
URI: | http://hdl.handle.net/10037/4072 |
Abstract: | Objectives. The objective of this study was to analyze the birth and induced abortion on demand (IAD) rate among women in Sami-speaking communities and a control group in Finnmark County, Norway. Methods. The 6 northern municipalities included in the administration area of the Sami language law (study group) were matched with a control group of 9 municipalities. Population data (numbers, sex and age) were accessed from Statistics Norway. Data on birth rate and IAD during the time period 1999 2009 were derived from the Medical Birth Registry (MBR) of Norway. Data on number of women in fertile age (15 44 years) were obtained from Statistics Norway. Between 2001 and 2008, this age group was reduced by 12% (Sami) and 23% (controls), respectively. Results. Finnmark County has a high IAD rate and 1 in 4 pregnancies (spontaneous abortions excluded) ended in IAD in the study and control groups. The total fertility rate per woman was 1.94 and 1.87 births, respectively. There was no difference between groups with regard to the IAD/birth ratio (P 0.94) or general fertility rate GFR (P 0.82). Conclusions. Women in the Sami-majority area and a control group in Finnmark County experienced a similar frequency of IAD and fertility rate. |
URI: | http://hdl.handle.net/10037/6069 |
Abstract: | Systemic inflammation and elevated circulating levels of the endogenous nitric oxide inhibitor asymmetrical dimethylarginine (ADMA) have been associated with increased risk in cardiogenic shock (CS). In this prospective study, we assessed, over 4 consecutive days, the changes and possible associations between vascular function, markers of inflammation, and circulating ADMA levels in patients with CS (n = 12) and postcardiotomy heart failure (n = 12, PC-HF). Vasodilator function was measured as a reactive hyperemia index (RH-index) using a finger plethysmograph. Blood samples were analyzed for plasma ADMA, interleukine-6, interleukine-8, intracellular adhesion molecule-1, and vascular adhesion molecule-1. Baseline RH-index was significantly attenuated compared with healthy controls (2.28) for both CS and PC-HF (1.35 and 1.45, respectively, P = 0.001). Although vasodilator function improved in PC-HF patients, it remained attenuated in CS. Inflammatory markers were markedly elevated followed by a significant fall during the observation period in both groups. ADMA levels increased significantly during the observation period for PC-HF, whereas no pattern of change was observed for CS. No association was found between the longitudinal changes in RH-index, markers of inflammation, or ADMA in CS. However, an improved RH-index was associated with decreasing inflammatory markers in PC-HF. ADMA correlated to arterial lactate levels and the degree of organ dysfunction in CS. In conclusion, CS and PC-HF were characterized by a marked inflammatory activation accompanied by an attenuated vasodilator function. ADMA was related to organ dysfunction and degree of hypoperfusion during CS but showed no correlations to inflammation or hampered vasodilator function. The pathogenic significance of these responses needs clarification |
URI: | http://hdl.handle.net/10037/4112 |
Abstract: | The knowledge about the relationship between health-related activities on the Internet (i.e. informed citizens) and individuals' control over their own experiences of health or illness (i.e. empowered citizens) is valuable but scarce. In this paper, we investigate the correlation between four ways of using the Internet for information on health or illness and citizens attitudes and behaviours toward health professionals and health systems and establish the profile of empowered eHealth citizens in Europe. Data was collected during April and May 2007 (N = 7022), through computer-assisted telephone interviews (CATI). Respondents from Denmark, Germany, Greece, Latvia, Norway, Poland and Portugal participated in the survey. The profiles were generated using logistic regressions and are based on: a) socio-demographic and health information, b) the level of use of health-related online services, c) the level of use of the Internet to get health information to decide whether to consult a health professional, prepare for a medical appointment and assess its outcome, and d) the impact of online health information on citizens' attitudes and behavior towards health professionals and health systems. Citizens using the Internet to decide whether to consult a health professional or to get a second opinion are likely to be frequent visitors of health sites, active participants of online health forums and recurrent buyers of medicines and other health related products online, while only infrequent epatients, visiting doctors they have never met face-to-face. Participation in online health communities seems to be related with more inquisitive and autonomous patients. The profiles of empowered eHealth citizens in Europe are situational and country dependent. The number of Europeans using the Internet to get health information to help them deal with a consultation is raising and having access to online health information seems to be associated with growing number of inquisitive and self-reliant patients. Doctors are increasingly likely to experience consultations with knowledgeable and empowered patients, who will challenge them in various ways. |
URI: | http://hdl.handle.net/10037/3862 |
Abstract: | Introduction We recently demonstrated that intravenously
infused recombinant human activated protein C (APC)
attenuates ovine lipopolysaccharide (LPS)-induced lung injury.
In this study, our aim was to find out whether treatment with
inhaled aerosolised APC (inhAPC) prevents formation of
increased lung densities and oedema and derangement of
oxygenation during exposure to LPS.
Methods: Sheep were anaesthetised during placement of intravascular introducers. After one to four days of recovery from instrumentation, the animals were re-anaesthetised, endotracheally intubated and mechanically ventilated throughout a six-hour experiment where the sheep underwent quantitative lung computed tomography. Sheep were randomly assigned to one of three groups: a sham-operated group (n = 8) receiving inhaled aerosolised saline from two hours after the start of the experiment; a LPS group (n = 8) receiving an intravenous infusion of LPS 20 ng/kg per hour and, after two hours, inhaled aerosolised saline over the next four hours; a LPS+inhAPC group (n = 8) receiving an intravenous infusion of LPS 20 ng/kg per hour and, after two hours, aerosolised APC 48 µg/kg per hour inhaled throughout the experiment. Data were analysed with analysis of variance; P less than 0.05 was regarded as significant. Results: An infusion of LPS was associated with a reduction of well-aerated lung volume and a rapid fall in arterial oxygenation that were both significantly antagonised by inhaled APC. Pulmonary vascular pressures and extravascular lung water index increased significantly during exposure to LPS, but inhaled APC had no effect on these changes. Conclusions: Inhalation of aerosolised APC attenuates LPSinduced lung injury in sheep by preventing a decline in the volume of aerated lung tissue and improving oxygenation. |
URI: | http://hdl.handle.net/10037/2171 |
Abstract: | Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Anesthetized sheep underwent right pneumonectomy, mechanical ventilation with tidal volumes (VT) of 6 mL/kg and FiO2 0.5, and were subsequently randomized to a protectively ventilated group (PROTV; n = 8) keeping VT and FiO2 unchanged, respiratory rate (RR) 25 inflations/min and PEEP 4 cm H2O for the following 8 hrs; an injuriously ventilated group with VT of 12 mL/kg, zero end-expiratory pressure, and FiO2 and RR unchanged (INJV; n = 8) and a group, which additionally received the inhibitor of nNOS, 7-nitroindazole (NI) 1.0 mg/kg/h intravenously from 2 hours after the commencement of injurious ventilation (INJV + NI; n = 8). We assessed respiratory, hemodynamic and volumetric variables, including both the extravascular lung water index (EVLWI) and the pulmonary vascular permeability index (PVPI). We measured plasma nitrite/nitrate (NOx) levels and examined lung biopsies for lung injury score (LIS). Both the injuriously ventilated groups demonstrated a 2–3-fold rise in EVLWI and PVPI, with no significant effects of NI. In the INJV group, gas exchange deteriorated in parallel with emerging respiratory acidosis, but administration of NI antagonized the derangement of oxygenation and the respiratory acidosis significantly. NOx displayed no significant changes and NI exerted no significant effect on LIS in the INJV group. Inhibition of nNOS improved gas exchange, but did not reduce lung water extravasation following injurious ventilation after pneumonectomy in sheep. |
URI: | http://hdl.handle.net/10037/4889 |
Abstract: | We describe a psychoeducational program integrated in a basic computer skills course for participants suffering from social anxiety. The two main aims of the course were: that the participants learn basic computer skills, and that the participants learn to cope better with social anxiety. Computer skills were taught by a qualified teacher. Psychoeducation and cognitive therapy skills, including topics such as anxiety coping, self-accept, and self-regulation, were taught by a clinical psychologist. Thirteen of 16 participants completed the course, which lasted 11 weeks. A qualitative analysis was performed, drawing on observations during the course and on interviews with the participants. The participants were positive about the integration of psychoeducation sessions in the computer course, and described positive outcomes for both elements, including improved computer skills, improved self-esteem, and reduced social anxiety. Most participants were motivated to undertake further occupational rehabilitation after the course. |
URI: | http://hdl.handle.net/10037/3593 |
Abstract: | Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under
development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result
in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting
in hybrid viruses with unpredictable characteristics. Previously, we confirmed that co-infecting in vitro a
Modified vaccinia virus Ankara (MVA) strain engineered to express influenza virus haemagglutinin (HA) and
nucleoprotein (NP) genes with a naturally occurring cowpox virus (CPXV-NOH1) resulted in recombinant
progeny viruses (H Hansen, MI Okeke, Ø Nilssen, T Traavik, Vaccine 23: 499–506, 2004). In this study we
analyzed the biological properties of parental and progeny hybrid viruses.
Results: Five CPXV/MVA progeny viruses were isolated based on plaque phenotype and the expression of influenza virus HA protein. Progeny hybrid viruses displayed in vitro cell line tropism of CPXV-NOH1, but not that of MVA. The HA transgene or its expression was lost on serial passage of transgenic viruses and the speed at which HA expression was lost varied with cell lines. The HA transgene in the progeny viruses or its expression was stable in African Green Monkey derived Vero cells but became unstable in rat derived IEC-6 cells. Hybrid viruses lacking the HA transgene have higher levels of virus multiplication in mammalian cell lines and produced more enveloped virions than the transgene positive progenitor virus strain. Analysis of the subcellular localization of the transgenic HA protein showed that neither virus strain nor cell line have effect on the subcellular targets of the HA protein. The influenza virus HA protein was targeted to enveloped virions, plasma membrane, Golgi apparatus and cytoplasmic vesicles. Conclusion: Our results suggest that homologous recombination between poxvirus-vectored vaccine and naturally circulating poxviruses, genetic instability of the transgene, accumulation of non-transgene expressing vectors or hybrid virus progenies, as well as cell line/type specific selection against the transgene are potential complications that may result if poxvirus vectored vaccines are extensively used in animals and man. |
URI: | http://hdl.handle.net/10037/2191 |
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text:
11-07-2013 12:44 AM - edited 11-07-2013 01:21 AM
Hi i'm SallyLoh. I've my first child who is 19 months old now- born March 2012 through
inducing although my baby not due yet and then, through ceacearean because he
passed-motion in my womb already. However, he is healthy when born, active and playful boy now.
I conceived him around less than a month immediately after my marriage. Now, I'm
trying for the second child but it seems difficult because its has been 6 months plus.
My hubby is already 41 yrs old and i'm 37 now. Is it because of our age or other
factors? We are not a smoker or drinker. We are of medium size. I seemed to conceive
very well for my first child but why not the second child now? Pls advise. If you are a doctor,
nurse or someone has the same problem, pls help.
It also took us 6 months to conceive our second kid. But most importantly, I think you need to relax more and don't stress with work. Remember to target your ovulation days. Good luck!
hi Mumsafari, yeah i may be worrying and afraid that it may takes a longer time. Actually i can't wait because of my age. May i know when you conceived your second child, did you have intercourse at daytime or nightime? I got my first child because i've my intercourse at nightime so i thought my second child will be the same. Did you do the same or otherwise? Please share. Thanks.
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subset: commoncrawl


text:
Chronic Compartment Syndrome
Pronounced: com-PART-ment SIN-drome
En Español (Spanish Version)Chronic compartment syndrome (CCS) occurs when pressure builds up within the body's muscle compartments. Compartments are made of sheets of connective tissue called fascia. These sheets are under the skin of the arms and legs. They wrap around groups of muscles, nerves, and blood vessels. When pressure builds up in the compartments, it disrupts or blocks blood flow to the muscles and nerves.
Unlike acute compartment syndrome, CCS is not an emergency. However, you should see your doctor to get treatment.
Compartment Syndrome in Lower Leg
Copyright © Nucleus Medical Media, Inc.
Last reviewedDecember 2014by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.


text:
to copy a design needs often a lot of time to rename.
If the copy should bei in the same folder, you have to delete at every file the " (2)" and rename it.
There are the options prefix and suffix but i think its not enough.With them you can olny add something, not replace ore delete.
With options like rename it will be quicker.
You have files with speeking filenames like this:
and want to make this:
you have need a lot of time.
Best regards
I forget something:
with PTC Intralink / Windchill you can make this example easy with:
Replace ".025" with ".026"
I think thats something for Vault, too.
Also add mass-selection for files in Copy Design. Thus you'll be able to select a "copy/reuse" option for several files at time.
You CAN do a replace function in Copy Design, at least as of Vault 2011.
In the file name or loction column, right click and choose replace. It takes some time, but is still a lot quicker than changing each one individually.
I try to set up my file name structure such that there is a common field in all of my file names, which is easy to replace in copy design... for example I prefix everything with the project number.
cbenner is correct. you have to make sure you right click on the cell and not on the column header, which is counter intuitive. But its definitely there.
I found it, too. It works. Thanks to cbrenner.
From my side, this thread can be deleted.
But with this hits, i seems, that others had missed this function, too.
It seems that this function is to hidden. I think the place at the front like prefix and suffix is the better one.
The rename/replace is really exists.
But what about selecting an option for several files at one time or applying option for children?
Hi all
Took me a while to find it too... there is a bit of a trick to the right-clicking
The renaming could definetly use more options
If they need ideas, it could have similar options to the freeware program 'Bulk Rename Utility'
I find that the 'Replace All' rarely works, and that I have to click 'Replace' for every instance... anyone else have this bug?
I am running Collaboration 2011
I find that the 'Replace All' rarely works, and that I have to click 'Replace' for every instance... anyone else have this bug?
I have exactly the same situation. 99% of the time I have to select every instance. And like others mentionded before, a well hidden feature. I never knew it. It will save us a lot of work. (esp. copy design of tube&Pipe, frame generator and stress files)
There is a replace funktion in the "Copy Design dialog" ..
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Incredible! 5.0/5
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This is really yummy, filling, and can be eaten even in phase 1of the diet with a nice side of (2 cup serving) salad greens Submitted by JLOSCOOPS Carbs: 46g | Fat: 6.2g | Fiber: 14.1g | Protein: 14.2g | Calories: 287.6
This quick and healthy side dish takes just minutes to prepare! And as a bonus, it's an easy way to get the kids to eat their vegetables. Submitted by MATCM81 Carbs: 7.3g | Fat: 1.6g | Fiber: 2.5g | Protein: 3.2g | Calories: 51.6
I stole this recipe from memebr MrsMohr.... she was on vacation and I wanted to add all the stuff together, so this is hers!! It is the only mashed cauliflower recipe I actually love! Submitted by SNAVELA1 Carbs: 5.8g | Fat: 7.9g | Fiber: 2.5g | Protein: 6.1g | Calories: 116.2
I love this recipe, I made this up to flavor up some chicken and eat it al the time since I have been dieting. It is so good! I hope you all think so too! I like this the best with the chicken cooked on the grill but you can do whatever method you like to cook the chicken. Submitted by SNAVELA1 Carbs: 5.5g | Fat: 8.2g | Fiber: 1.1g | Protein: 41.2g | Calories: 285.6
Yellow squash, eggplant, zucchini, onions, tomatoes all baked with a cheesy crust. Great vegetarian and low carb side dish. Submitted by MEGRENEE2 Carbs: 6.6g | Fat: 4.1g | Fiber: 1.9g | Protein: 7g | Calories: 89.7
Incredible! 5.0/5
(5 ratings)
This is a breakfast I used when I was on the South Beach Diet. It can be eaten in Phase one and was actually really good Submitted by GALNBLUE81 Carbs: 8.1g | Fat: 13.6g | Fiber: 1.1g | Protein: 22.3g | Calories: 245.3
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Submitted by CHAOSDAD71 Carbs: 2.6g | Fat: 7.9g | Fiber: 1.3g | Protein: 11g | Calories: 135.5
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text:
Vishay Precision Group To Announce Third Quarter 2011 Financial Results Tuesday, November 1
Vishay Precision Group, Inc. (NYSE: VPG) ("VPG or the Company"), a leading producer of precision sensors and systems, based on its resistive foil technology, will release results for the third quarter ended October 1, 2011 at approximately 8:00 a.m. (ET) on November 1, 2011.
A conference call and simultaneous audio webcast will take place at 10:00 a.m. (ET) on November 1, 2011. To access the conference call, interested parties may call 877-317-6789 or +1-412-317-6789 and enter conference number: 1000-4832, or log on to the IR page of the VPG website at http://ir.vishaypg.com for listen-only mode.
A replay will be available approximately one hour after the completion of the call by calling toll-free 877-344-7529 or internationally +1-412-317-0088 and using the conference number: 1000-4832. The replay will also be available on the IR page of the VPG website at http://ir.vishaypg.com. It will be available via phone and website for a limited time.
About Vishay Precision Group
Vishay Precision Group produces precision sensors based on its resistive foil technology, and sensor-based systems. VPG provides vertically integrated products and solutions for multiple growing markets in the areas of current, stress, force, weight, and pressure measurements. As a spin-off from Vishay Intertechnology, the Company has a decades-long track record of innovation in foil precision resistors, current sensors, and strain gages, which serves as a foundation for its more recent expansion into strain gage instrumentation, load cells and transducers, weighing modules, and complete systems for process control and on-board weighing. Vishay Precision Group may be found on the internet at www.vishaypg.com.Check Out Our Best Services for Investors
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text:
A nano-positioning system for macromolecular structural analysis
Very often, the positions of flexible domains within macromolecules as well as within macromolecular complexes cannot be determined by standard structural biology methods. To overcome this problem, we developed a method that uses probabilistic data analysis to combine single-molecule measurements with X-ray crystallography data. The method determines not only the most likely position of a fluorescent dye molecule attached to the domain but also the complete three-dimensional probability distribution depicting the experimental uncertainty. With this approach, single-pair fluorescence resonance energy transfer measurements can now be used as a quantitative tool for investigating the position and dynamics of flexible domains within macromolecular complexes. We applied this method to find the position of the 5' end of the nascent RNA exiting transcription elongation complexes of yeast (Saccharomyces cerevisiae) RNA polymerase II and studied the influence of transcription factor IIB on the position of the RNA.
In recent years, high-resolution structural models of large macromolecular complexes such as the ribosome, the RecBCD helicase or RNA polymerases have been obtained using X-ray crystallography. Although these structures provide detailed insight into the molecular architecture of complex biological systems, the position of flexible domains can usually not be determined because of averaging effects.
Single-molecule methods, on the other hand, provide the possibility of directly obtaining structural information because they allow the study of real-time conformational changes of macromolecular complexes. In combination with fluorescence resonance energy transfer (FRET), a technique that has been termed a molecular ruler, one can in principle measure distances within a macromolecule in real-time. However, because of experimental problems such as variations in quantum yield or dependence of FRET on the orientations of the two dye molecules, there are few examples in the literature of quantitative distance measurements or position determination using single-pair FRET (sp-FRET). Instead, these data are more often interpreted in a qualitative fashion monitoring conformational changes and length increases or decreases.
Using triangulation of several FRET distance measurements, it is possible to determine a previously unknown position. Although these experiments are able to estimate the most likely position, they do not show how existing experimental uncertainties might affect the position determined. Therefore, these positions must be interpreted with great caution because one has no information about the experimental accuracy. In principle, one can conduct control measurements that provide validity tests of the position determined, but to arrive at a quantitative technique, experimental uncertainties must be taken into account.
Here we used bayesian parameter estimation, a probability-based analysis method, to compute the three-dimensional probability density function for the position of a so-called 'antenna dye molecule' (ADM) attached to a flexible domain within a macromolecular complex. By determining its position, we inferred the position of the flexible domain. We measured the FRET efficiencies between the ADM and several 'satellite dye molecules' (SDMs) attached to known positions. Within the bayesian framework we were able to account for errors (due to orientational effects) in the Förster radii determined, errors in the measured FRET efficiencies and uncertainties in the SDM positions (due to the attachment of the SDMs by means of flexible linkers). Moreover, we were able to account for geometric constraints such as occluded volumes and maximum distances. From the calculated probability density function, we directly obtained the most likely ADM position and the associated three-dimensional credibility regions reflecting the experimental uncertainties. This method has similarities with the Global Positioning System (GPS), and we therefore termed this technique 'Nano Positioning System' (NPS).
As an example, we used NPS to study the position of nascent RNA in yeast RNA polymerase II (Pol II) elongation complexes. We had previously used sp-FRET–based triangulation to follow the path of the nascent RNA and shown that RNA leaves the active-site cleft of the polymerase through the so-called exit tunnel and then follows a path across the dock domain.
Here we applied NPS to determine the position of an ADM attached to the 3' or 5' end of a 29-nucleotide (nt)-long RNA in a Pol II elongation complex. Moreover, we have investigated how the latter position is influenced by the presence of transcription factor IIB (TFIIB). The results allow us to explain discrepancies between recent RNA chemical cross-linking experiments and single-molecule fluorescence data on the position of the RNA, and they have implications for our understanding of the transition from transcription initiation to elongation.
"A nano-positioning system for macromolecular structural analysis"
Adam Muschielok, Joanna Andrecka, Anass Jawhari, Florian Brückner, Patrick Cramer, Jens Michaelis
Nature Methods 5, 965 - 971 (2008)
Adam Muschielok
since 2006
PhD student in the group of Prof. Jens Michaelis, LMU Munich
2001 - 2005
Diploma in Physics at the TU Munich
Selected Publication
J. Michaelis, A. Muschielok, J. Andrecka, W. Kügel, and J. Moffitt:
"DNA based molecular motors"
Physics of Life Reviews (2009)
Ioanna Andrecka
since 2009
Postdoctoral research at the LMU München in the group of Prof. Jens Michaelis
2005 - 2009
Doctoral Thesis, Supervisor: Prof. Dr. Jens Michaelis, LMU Munich
2004 - 2005
PhD Studies of Biochemistry and Biophysics, Jagiellonian University of Cracow, Poland
1999 - 2004
Interdisciplinary, Individual MSc Studies of Mathematical and Natural Sciences, Jagiellonian University of Cracow, Poland
Selected Publication
Andrecka J., Treutlein B., Arcusa M.A., Muschielok A., Lewis R., Cheung A.C., Cramer P., Michaelis J.:
"Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex"
Nucleic Acid Research 37 (17), 5803-9 (2009)


text:
Sad post-Thanksgiving news: Charlestown's much-loved seasonal sipping spot Tavern on the Water won't reopen in the spring, says Adam's Hospitality via the Boston Business Journal. Maybe the Legendary Restaurant Group, who owns the spot, is busy with their other endeavors, which include Downtown Crossing's new Sip/Avery Provisions and Somerville's soon-to-open protein palace Burger Dive?
We've reached out to the Legendary Restaurant Group's rep for the details, but we do have a sinking feeling, based on this recent missive from a fan on their Facebook page: "Is your restaurant still open? Some of your local neighbors came over the other night before Thanksgiving and were disappointed to find the place totally dark."
But there's no official goodbye on their page (yet), so maybe, just maybe, it's all just one big misunderstanding?
Update: A rep tells us that the closure is confirmed: "It was a business decision based on the current expansion plans and the concept didn't fit with the rest of their portfolio. Therefore, they decided not to resign the lease but rather focus on the core group of brands they are expanding."
Charlestown Navy Yard's Tavern on the Water shuts down [BBJ]
Related: Burger Dive Closes in on Opening, Thankfully


text:
Bird Construction (BDT.un) did not increase its distribution as you wrote. It must be a mistake.
I have asked my data supplier to review as I cannot find any news release which would confirm the distribution increase either.
Bird Construction (BDT.un) did not increase its distribution as you wrote. It must be a mistake.
scomac wrote:Metro (MRU.A) - Declared dividend of $0.125 per share, up 8.7%
Nexen Inc. (NXY) posted record first-quarter earnings on solid production, attractive commodity prices and high operating margins, leading it to double its quarterly dividend to 5 Canadian cents a share.
Davis + Henderson also announced its intent to increase its distributions for the month of May 2008, payable on June 30, 2008, to $0.1533 per unit (equivalent to $1.84 per unit annualized), subject to normal course regulatory requirements. This represents a 7.2% increase over distributions declared for the month of April 2008, which were equivalent to $1.72 per unit annualized. This increase in distributions recognizes the recent performance of the business, expectations of future performance and the need for the Fund to pay distributions sufficient to ensure the Fund itself is not taxable.
...declared a semi-annual dividend of 10 cents Canadian (C$0.10) per share on the Company's common shares. This represents a 14% increase from the previous semi-annual dividend the Company paid on its common shares. The dividend will be paid on June 30, 2008 to shareholders of record at the close of business on June 6, 2008.
TORONTO, ONTARIO--(Marketwire - May 6, 2008) - Barrick Gold Corporation (NYSE: ABX)(TSX: ABX) today announced that its Board of Directors has increased its June dividend to US20 cents per share from US15 cents per share. The dividend is payable on June 16, 2008 to shareholders of record at the close of business on May 30, 2008.
TORONTO, May 27 /CNW/ - Scotiabank today increased the dividend on its common shares by 2 cents to 49 cents per common share for the quarter ending July 31, 2008.
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Protection issues - Crashes and Skulls.
Posted 26 November 2012 - 05:01 PM
I totally understand that those who have paid for GameMaker and are getting this are feeling very upset by the whole matter, and I can only apologise for the problems. As to why its in there should be reasonably clear. GameMaker has traditionally been one of the most pirated programs around, and its simply not right that some pay good money for it, while others simply pirate it. We try hard to make it as smooth an experience as possible for paying users, but are constantly fighting pirates understanding of the protection systems.
Wed LOVE to be able to remove the protection completely, but we know that vast numbers would simply copy it if it was that easy. There are many levels to the current protection system, and while many are visible like this, there are also many hidden so that we can always tell when a final game was created with a crack.
We expect an update to go out tomorrow to remove this protection, and will move away from the destructive protection like this, to more passive methods to help protect innocent users who through no fault of their own, somehow trigger it.
As to why we dont just switch into FREE mode, this is because crackers can simply activate features while the program is running, so doing this serves no purpose other than to annoy paying customers.
We're obviously well aware of this issue, so I'll close the other threads and you can feel free to attach yourself to this one. We'll keep you updated as things develop, and assure you we are working to get a new version out to you as soon as we can.
Posted 26 November 2012 - 07:25 PM
Posted 26 November 2012 - 09:51 PM
I completely support most methods to combat piracy. I really hate piracy because God forbid, if I don't buy that next module or that next iteration of GameMaker, Mike or Russell won't be able to feed themselves and I won't let that happen.
I actually know of people who believe in the notion that software should always be free, it is really staggering that these are their excuses to pirate.
Posted 26 November 2012 - 09:56 PM
Or is this crashing a totally different issue?
Posted 26 November 2012 - 10:03 PM
A certain number will NEVER buy - EVER! These folks are basically crooks, and you can not count these as lost sales. No matter how "cheap" you make it, some will simply never buy. A good case in point is the current sale. for $50, you can get pro+html5. This means your getting a massive 75% off, and Pro for $25 (about £15). This is incredibly cheap, yet I know lots of them will keep just stealing if they possibly can.
We simply don't care about them, but if I can piss them off, I will.
At the same time, there are some who simply can't afford it, and we want to encourage them to buy whenever possible. Sales like the current one (and I'm sure future ones) are a great chance for these folk to get on the ladder (as it were), but I realise some will simply never manage. I hold nothing against folk like this. Cheap for us, is not cheap for everyone.
Then there are the last load, who will copy because it's easy, so why bother buying. These are the ones who WILL buy, if they get annoyed enough with cracks that don't work correctly, or when they realise they can't release anything without being found out - because yes... we KNOW what games are created with cracks. So these are mainly the ones we look to convert with things like this. These and the previous group are the ones we care about. Those who never buy, will copy stuff mainly to just to say they "have it", and won't usually do anything with it (although some might). But these other 2 groups, are the ones who would like to do something, and we'd like them to buy where ever possible.
For those who can't afford it. We have a free version, and if coded correctly, you can make anything. We've left in specific "gaps" to allow you to do some large projects if you try.We also have Standard, which we let you upgrade to Pro for the difference in price. We might try and do more later, but this is the best we can do for now.
For those who CAN afford it, but find it just as easy to copy it. Well, rest assured, we know the games which get made, and if something does well.... I'm sure we'll be in touch.
I understand crackers doing it too. It's a challenge, and it's fun. Also the praise you get form folk wanting to use it, can be somewhat intoxicating. Being told by so many that your amazing or awesome, is always a great feeling. I have respect for those that crack it, and don't release it, and even for those that crack it, but "mark" the result in some way to make it obvious the user used a crack. This lets folk try it, but they know they can't truly use it. But these crackers are rare, which is a shame.
So yes.... we can never "win". Hardware dongles can be cracked and removed, all software can be "fixed". Only "online" can reduce piracy properly, and even that can be removed by some dedicated hacker. That said, the more the world moves online, the easier it gets to block, but we're not there yet, so we do what we can.
I said it before. If I could remove the DRM and know we'd get the same or more sales, I'd do it in a heart beat. I have HUGE respect for those that provide totally DRM free software, but for now, GameMaker is simply pirated too much.
I'm rambling now... Well... when I say NOW... I mean I have been for some time.
Posted 26 November 2012 - 10:55 PM
I also have a method for protecting the development tool if you want to know it, PM me. From this experiment, I'm gather there is someone at yoyo that is interested on the subject of piracy protection.
Posted 27 November 2012 - 12:25 AM
Here's an idea, make the program compile the code on your server...
Here I am assuming you're referring to the YoYoGames server.
This is a terrible idea when it comes to those of us who don't have a dedicated internet connection. Every once in a while I have to DL the license file, and so far that has worked well, even though at first I was hoping I wouldn't have to do that. This means I have to make a specific trip in to town to DL this file. Fine, I can live with that.
But then I've heard comments on here similar to this one, I paraphrase it very loosely:
"If you're serious about making games, then blah-dee-blah-blah [i.e. then you should also be serious about your internet connection]."
And no, that comment does not apply to some of us who are out of reach of conventional internet connections, living in a deep valley without cable internet or stable satellite or other over-the-air connection.
And aside from that, there are still large populations on this planet who pay heavily for each meg downloaded/uploaded. Cable-or-other-high-speed internet connection is a privilege, which sadly, is taken for granted by too many people both in the USA and Europe (and elsewhere, I assume but I've mainly had experience with those two).
Anywho, just my two pennies on that particular thought.
Posted 27 November 2012 - 12:51 AM
...dedicated connection
Note that I implicitly stated code compilation, expressing only the code would be sent to the server... About 200K of text (your code), coming back as byte code (smaller than source) to be build into the exe with the local resources (Megabytes stay local). Even a dialup connection can handle that.
And it would only do this when you make an exe
>>This means I have to make a specific trip in to town to DL this file. Fine, I can live with that.
That is sad. Do you not have at least a 56Kb modem access from home? Like we did in the 80's. 200K source + 75K return would take 45 seconds to transmit and receive.
Wait a minute... you are online now? Do you have to drive to town for that?
Posted 27 November 2012 - 02:06 AM
...Do you not have at least a 56Kb modem access from home?...
No landline at home. Have a cellphone with an awful connection at home but fine in town/elsewhere.
...Wait a minute... you are online now? Do you have to drive to town for that?
Online at work /> (And no, I'm not installing GM at work! /> /> )
Posted 27 November 2012 - 02:28 AM
Edited by angryempath, 27 November 2012 - 02:28 AM.
Posted 27 November 2012 - 03:55 AM
Posted 27 November 2012 - 06:19 AM
Edited by Big J, 27 November 2012 - 06:20 AM.
Posted 27 November 2012 - 07:38 AM
This protection has been in for some time, and does help keep pirates busy trying to figure out how to remove it, but I also agree it's unacceptable that it's effecting paying users - which is why this particular check is being removed just now.
If I thought for one minute we were going to effect customers, I'd never have put it in. Something we simply didn't expect has been happening on end users machines, and while we think we now know, again, I agree, customers should never - ever - be effected by it.
Of course, how I feel about effecting pirates project files is less...err... clear.
Remember the goal is to drive pirates to buy, and if they think a copy will destroy their game, that's a pretty strong incentive. However, we'll make sure our concern for paying customers now takes precedence over trying to force a sale from a pirate - which will probably not happen anyway.
We've become blinkered a little in trying to stay one step ahead, and for that I totally apologise, there are certainly other ways of doing this.
Posted 27 November 2012 - 08:35 AM
Posted 27 November 2012 - 02:05 PM
Posted 27 November 2012 - 02:31 PM
Would be nice to get a official solution rather then a discussion on the importance of DRM!! />
Oh, and I'm running WIndows 8 with version 1.1.666 after fresh intstall (and the folder/registry cleanup) and I still have the S & B's in my sprites.
Edited by Robto, 27 November 2012 - 02:33 PM.
Posted 27 November 2012 - 02:38 PM
I tested it running Steam in both offline and online modes and it crashes the same.
I'm using Windows 7.
I have tried deleting Game Maker through Steam and redownloading/installing it but that didn't change anything.
I have not tried deleting the appdata and reinstalling; I'll try that next and update this post if it made any difference.
Also, probably unrelated, but a few days ago it did give me the skulls using the free Studio version on Steam but it only happened once and thankfully I didn't save.
Finally and almost completely unrelated but I really feel you should know that the way Game Maker Studio is sold on Steam, if the software is uninstalled (delete local files) from Steam, like I just did, then it is wholly removed from your Steam library. I think it's because everything you buy is DLC for the free product but that was disconcerting to me but re-downloading the free version put it back in my Steam library. I'm sure it's not your fault but it's probably something you'd want to change or get Steam to fix as I can see a lot of complaints coming from that.
It still crashed for me but it took quite a bit longer this time... so... progress? Anyway, I'll wait for the update.
Edited by plural, 27 November 2012 - 03:02 PM.
Posted 27 November 2012 - 04:36 PM
@Steam: yes... the free one is actually the ONLY download, and it's all unlocked digitally once it's run.
Posted 27 November 2012 - 04:41 PM
skull all over my screen. hope the fix comes soon.
Posted 27 November 2012 - 04:44 PM
Posted 27 November 2012 - 04:55 PM
Posted 27 November 2012 - 05:25 PM
Posted 27 November 2012 - 07:49 PM
Posted 27 November 2012 - 10:09 PM
Posted 28 November 2012 - 01:27 AM
Posted 28 November 2012 - 01:37 AM
Posted 28 November 2012 - 01:47 AM
I am glad, you have decided to take out this type of DRM Mike, thank you.We have considered a lot of these options, and I agree with Futhark, the world isn't quite there yet. Perhaps as an option in the future or something, but not yet.
This protection has been in for some time, and does help keep pirates busy trying to figure out how to remove it, but I also agree it's unacceptable that it's effecting paying users - which is why this particular check is being removed just now.
If I thought for one minute we were going to effect customers, I'd never have put it in. Something we simply didn't expect has been happening on end users machines, and while we think we now know, again, I agree, customers should never - ever - be effected by it.
Of course, how I feel about effecting pirates project files is less...err... clear. />
Remember the goal is to drive pirates to buy, and if they think a copy will destroy their game, that's a pretty strong incentive. However, we'll make sure our concern for paying customers now takes precedence over trying to force a sale from a pirate - which will probably not happen anyway.
We've become blinkered a little in trying to stay one step ahead, and for that I totally apologise, there are certainly other ways of doing this.
Posted 28 November 2012 - 01:56 AM
If anyone is smart, they would make constant backups of their project files. Thankfully, my team has assigned days where each person updates the folder. Just had to replace the sprite directory with a simply copy and paste. It should not have set back too many people.
I hope you guys can find a better way to detect actual pirated copies. I figure it's tough to be a starting business as yourself, that's always the hardest obstacle for any company.
Posted 28 November 2012 - 05:12 AM
I'm not majoring in Law so I wouldn't know, but isn't targeting and destroying someone's data (in a malicious manner identical to that of a virus) of questionable legality at best? Regardless of whether or not the victim is committing a crime?
Here you have even stated that destroying data is the intent of this feature.if they think a copy will destroy their game, that's a pretty strong incentive.
From what UK law leads me* to understand, it's completely illegal "to impair [...] the reliability of any such data". http://www.legislati...k/ukpga/1990/18 section 3.2.c
*IANAL, and other countries will of course have (slightly) different laws
The point I am making is that not only is this (likely to be) illegal, but it is also one of these DRM problems that are less likely to affect pirates.
/minirant, got linked here by a friend and this is one of the few ways to really raise my ire.
As for a slightly more constructive and slightly less "oh god the horror" comment (relating to data recovery ) -
I wonder how practical it would be to keep GM projects under version control... If the GM IDE ever got plugin support, this could become more feasible with simple(r-than-commandline) right-click menus for your favourite VCS.
Alternatively, the GM IDE could support silent compiling via command-line (errors going to stderr instead of GUI, etc.) and people could use custom GM IDEs, which would sidestep the problem of plugin systems altogether.
inb4 delete
Edited by score_under, 28 November 2012 - 05:17 AM.
Posted 28 November 2012 - 05:28 AM
(see the comment section)
So this week, at least for me, is skull terror and failing windows week. Wow XD
Edited by greyzebra, 28 November 2012 - 05:30 AM.
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text:
New Revised Standard (NRS) | New International Version (NIV) |
14 But the woman was given the two wings of the great eagle, so that she could fly from the serpent into the wilderness, to her place where she is nourished for a time, and times, and half a time. | 14 The woman was given the two wings of a great eagle, so that she might fly to the place prepared for her in the desert, where she would be taken care of for a time, times and half a time, out of the serpent's reach. |
New Revised Standard Version Bible, copyright 1989, Division of Christian Education of the National Council of the Churches of Christ in the United States of America. Used by permission. All rights reserved. (New Revised Standard Bible Version Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


text:
Sep 3
Stoke on Trent is the main backdrop for the feel good, coming of age film Soulboy; set around the Northern Soul underground music scene. Soulboy is out now for general release, visit the official Soulboy website: www.soulboythefilm.com.
A host of venues across the city were used in the shooting of the new movie SoulBoy, including the Kings Hall in Stoke which played the part of legendary Wigan Casino (shut in 1981).
The Independent have today named it as the film of the week, by a distance. Read Anthony Quinn of The Independent's review here.
If you are looking for something to do this weekend, then here at Agog, we advise you to watch Soulboy at the cinema.


text:
Through the Sunlight: Sunlit Photography Showcase
- By Emily Williams
- Posted in Inspiration, Photography
- 19 comments
What can be more eye-catching and charming than a colorful sunlit photo slightly spiced with golden lights and deep emotions? Such fantastic pictures are best taken in the early morning or late afternoon, when the light direction and color is more usable than in midday. The time when the sunlight is warmer, red and yellow tints are stronger and all these tiny elements create an especially happy atmosphere.
Have a look at the sunlit photography showcase below and appreciate how skilfully the photographers captured their subjects, grabbing the most attractive angle, played with the colors and highlighted each magnificent detail. It seems that the whole World stops and admires the sublimity of the enchanting minute, its brilliance, brightness and clearness.
Through the Sunlight
Sun Rays in the Slot Canyon by Kaye Duncan
Toronto's Dales of Tales by Katrin Ray
Spotted eagle ray at sunrise by Barry Fackl
Every blade of grass by photos=happiness
Ray of Enlightenment by Kartik Jasti
A ring around the sun by Cynthia-E.-Wo
Beautiful Sun Ray by Richard Wong
Sun In My Mouth…!!! by Denis-Collette
Sunlight Through Kelp by Peter Liu
…and I wake up alone… by bqdockey
Sunlight Penetrates by Canis Major
among the dewy blades of grass…pfairman53
Tender Dawn Sunlight and Leaves by D. Sharon Pruitt
Sunlight through flower seeds by Alan Grinyer (soulman53)
Sunlight on Whitby marina by Andreadm66
Warmth of the Sun by brendan mills
Happy sunlights by George Dolgikh
Awesome Sun Ray by jasper vale
Embrasure For The Sun by Carlos Henrique Reinesch
Edge Of The World by Carlos Henrique Reinesch
Angel Of The City by Carlos Henrique Reinesch
The Hanging Time by Carlos Henrique Reinesch
Kiss Me Sunlights by Korpinkynsi
Secret Portal by Bladewing Flash
Through the Drawing Board by Gilderic Photography
Magic sealights by FlammingDev
Tainted Veins by onesynergy-d2vmunu
Bubbles: Sunlight by Bree Spawn
From a fairy's perspective by Cattereia
Not Quite Over
If you also have striking examples of photos with charming lights, just show your artworks to the curious Noupe audience, tell about your photography experience or simply share your thoughts and feelings on the post in comments section!
Emily Williams is a passionate writer who proudly claims that girls can run design blogs too! To make sure why she is so confident of it just visit her blog DesignWebKit
- Pavlushka, 24 August 2012
Awesome collection! I like all the photos
Thank you, Emily for sharing!- Emily Williams, 24 August 2012
Thanks Pavlyshka) I also like your articles on Noupe ;) keep up a good work! ;)
- John, 24 August 2012
The "Through the Drawing Board" photo is fantastic. I wish I had a workplace that looked even remotely as inviting.
- Emily Williams, 24 August 2012
John thank you for your comment! ;) Yes, this workspace is really amazing and very inspiring! Looks like a secret magic place ;)
- Sagarsinh, 25 August 2012
Good collection :) "Beautiful Sun Ray" photo is beautiful :)
- mad madrasi, 25 August 2012
Fantastic collection. I like Sun Ray & Beautiful Sun Rays & Rays by Sumanth Suresh. I could keep watching them all day – so pleasing.
- Cyrus, 26 August 2012
I took some weeks ago a picture that might be in the same wave than these : http://www.flickr.com/photos/why-so-cyrus/7810509964
- Stacy Summers, 27 August 2012
Emily, your roundup is amazing! Happy sunlights by George Dolgikh is so inspiring! keep rocking :)
- Bas, 27 August 2012
Not the best collection if you ask me, I've seen much better.
- Nancy Young, 27 August 2012
I like it, Emily! Good job. I'd say, the pictures are mysterious and dreamy. Once again, thanks for sharing. In my opinion "The Handing Time" is the best one.
- George Dolgikh, 29 August 2012
Hey Emily! Thanks for including my photo in this great collection :) I'm so proud! 8)
- Gwen, 30 August 2012
There are some here too : http://www.behance.net/gallery/IRELAND/3944007
- Unaiz, 30 August 2012
Nice collection…! Like it
- Cristhian, 30 August 2012
Excellent article Em, lovely pictures :)
- Anny, 03 September 2012
Emily, the post is great! sunny pics look so great and make me smile
- Yelena, 09 September 2012
Thanks a lot for this great showcase!..
As we're invited to share more images of this kind, I'd like to offer you a couple of my own:
Both were taken in Sweden.
Hope to see more great photos on your page… - Mark, 30 September 2012
Hi Emily,
Thanks for including my photo. I'm honoured to be included in such a great showcase about light :) - mehul desai, 01 August 2013
awesome pics .. thanks
- Shushma, 18 March 2014
Awesome collection! Thanks for sharing. I like all the photos. Thank you Emily.


text:
A man has received serious head and facial injuries after he was attacked by a masked gang at a house in Londonderry.
Shortly after 2am on Saturday, three masked men entered the property on Ebrington Street and assaulted the man with hammers and bats.
He was treated in hospital for the injuries which are not thought to be life threatening.
Two men aged 26 and 41 years old were arrested following the incident and are helping police with their enquiries.


text:
Summary: A quarter-century after its first publication, A Shopkeeper's Millennium remains a landmark work--brilliant both as a new interpretation of the intimate connections among politics, economy, and religion during the Second Great Awakening, and as a surprising portrait of a rapidly growing frontier city. The religious revival that transformed America in the 1820s, making it the most militantly Protestant nation on earth and spawning reform movements dedicated to tempera ...show morence and to the abolition of slavery, had an especially powerful effect in Rochester, New York. Paul E. Johnson explores the reasons for the revival's spectacular success there, suggesting important links between its moral accounting and the city's new industrial world. In a new preface, he reassesses his evidence and his conclusions in this major work. ...show less
Edition/Copyright: (REV)0432 more offers below.
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text:
by Mary Wollstonecraft Shelley
Category: Classic Fiction / General
Publication date: 31 December 1995
Number of pages: 0
This new edition of Mary Shelley's classic text Frankenstein, edited by Marilyn Butler, is the first to show in detail why the 1818 edition should be preferred to the third edition of 1831, on which most modern editions are based. Drawing on new research, Butler places the novel in its original intellectual milieu, that of the radical sciences in the dynamic, difficult and dangerous climate for early evolutionism which followed France's defeat in the Napoleonic Wars. Marilyn Butler shows how the celebrated 'filthy experiment' relates to the public debate between champions of materialist science on the one side and received religion on the other. Frankenstein brought into the open some of the most feared innovations of evolutionism - topics such as degeneracy, hereditary disease, and mankind's status as a species of animal. Since its publication in 1818, Frankenstein has become one of the most famous nineteenth-century novels, inspiring countless imitators, devotees and critics. In Frankenstein - the story of an ambitious young scientist and the monster he unleashes - Mary Shelley (1797-1851) questions the mystery of nature and the 'principle of life'. She provides an unequivocal and moral comment on the industrial age. Mary Shelley's most famous work synthesises the prevailing philosophical attitudes of her day. Frankenstein has captured the public imagination with the questioning of scientific enlightenment, and its horrific subject matter throws into doubt the prevailing rational discourse. The Frankenstein of 1818 emerges as an expressive contribution to an important episode in the social history of science and ideas. It is also great black comedy: harder, wittier and cleverer than the pious version with which we are more familiar. The first authentic Frankenstein is a mocking expose of leaders and achievers who leave desolation in their wake, an unforgettable parable which shows mankind its choice - to live co-operatively or die of selfishness.
What the papers say:
'In this new edition of Mary Shelley's classic work, Butler ... sets the work in its historical and intellectual context. She shows in details why the 1818 edition should be preferred to the third edition of 1831, on which most modern editions are based, revealing the 1818 version to be wittier, more clever, and harder-edged than the pious version which is more familiar.' - Reference and Research Book News 'The first appendix, detailing the differences between the editions, is useful for Shelley scholars, and Butler's work on scientific debate nicely counterpoints and complements other recent work, which has tended to concentrate on more specifically feminist, social and political issues.' - Emma McEvoy, Goldsmith's College, University of London
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text:
Once upon a time we had a weedwacker even I could start. We are in our 70's and 80's now, still have lots of trees over large acreage to trim, and on our fourth gas trimmer. My DH has arthritis and can no longer pull much with his arms. If I remember right, our first weedwacker had a spool containing just one string. After starting the first time for me, I could go all over the farm and change my own string and restart the trimmer myself--with no problem. We have had three since then, all used just a few times, that sit in our garage. Battery trimmer was not powerful enough and too much area for electric trimmer.
If not, is there an engineer out there that would like to get rich--fast? Just invent a trimmer for me and others like me. PLEASE HURRY! |
Follow-Up Postings:
You might consider looking into one of the better (more $$) units like Sthil, or Echo. They really hold up, I have a Stihl that I've had for over ten years and it's still going strong. Also, the better units will take an attachment which allows individual very thick nylon strings to be attached. They're about 8" long and attach individually, that really saves the pain and anguish of fighting with rewinding, etc. Unfortunately, all two cycles have their particular "starting ritual" which, once mastered works well. A problem we currently have with the new gas with ethanol mixed in is carb fouling and issues like that. Get in the habit of putting a good stabilizer with good (I like the synthetic) two cycle oil in the can BEFORE you put the gas in. Good luck, Ev |
Am I seeing there are some electric start two cycle trimmers on the market? If so, do we have some personal owners that will share their experiences related to good or bad options on the trimmers? Cranking, Running, Durable Use (motor and line), all over a good period of time vs one year. Actually the three items might have to be separated since cranking is the issue and all requires different care. BUT! One brand or model might rate "User Friendly" in the three areas. Two Cycles appear to be Monsters to most people but they are not bad if you learn their nature and needs IMO. |
You might take a look at this one. Home Depot has them for $260. |
Here is a link that might be useful: Echo trimmer.
THIS IS INFORMATION ONLY - I DON'T HAVE ANY DIRECT KNOWLEDGE OF THE TRIMMER OR THE VENDOR. Here's an electric start string trimmer. Note that it is refurbished, but the listing says that it is warranteed. |
Here is a link that might be useful: Electric start trimmer
More Electric Start Info At: http://www.nextag.com/electric-start-lawn-trimmers/compare-html I need to see and use one of the systems before I can make direct comments. |
"Here's an electric start string trimmer."...If you get a Ryobi electric start trimmer it probably won't start, but at least you won't have to expend much energy. |
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