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Next PageAbstract: | Total parenteral ernæring (TPN) gis forebyggende eller korrigerende mot feilernæring til pasienter hvor oral eller enteral ernæring vanskelig lar seg gjøre. TPN inneholder glukose, fett og aminorsyrer i tillegg til viktige vitaminer, sporelementer og elektrolytter. TPN er en steril olje-i-vann (o/v) emulsjon, stabilisert ved hjelp av en lecitin-emulgator. Scenario hvor legemiddel og TPN må administreres samtidig, kan oppstå. Gjennom et Y-sett muliggjøres administrering av to komponenter parallelt, men per i dag praktiseres det i stor grad å stanse pågående TPN under medisinering. Dette fordi det foreligger en risiko for inkompatibilitet når komponentene møtes i Y-settet. Konsekvensene kan være alvorlige, dersom partikulær utfelling eller destabilisert emulsjon infunderes hos et barn. Tidligere kompatibilitetsstudier har i stor grad tatt for seg legemidler og parenterale næringer tilpasset den voksne befolkningen, og informasjon om kompatibilitet mellom legemidler og TPN tilpasset barn er etterlyst fra klinisk praksis. |
URI: | http://hdl.handle.net/10037/5395 |
Abstract: | The GPCR CXCR4 is a chemokine receptor that by activation of its natural ligand SDF-1α is involved in the pathology of several diseases like cancer metastasis, leukemia cell progression and rheumatoid arthritis. The finding that CXCR4 plays a critical role for HIV-1 entry into T cells prompts additional motivation for the design of CXCR4 inhibitor. The establishment of the possible binding mode(s) for the cyclopentapeptide FC131 is decisive for the development of such inhibitor. Induced fit docking, which allowed flexibility for both the ligand and receptor structure, was used to generate ligand-receptor complexes. The resulting poses were compared based on their XP score and two ligand binding modes were suggested. In addition to this, mutational analysis on three CXCR4 residues which are believed to be important for HIV infection of T cells was performed. |
URI: | http://hdl.handle.net/10037/2204 |
Abstract: | The use of genetically modified organisms - their release into the environment, import, and utilisation as food/feed or food/feed ingredients - is regulated in the European Union (EU). For placing onto the market, current legislations require a comprehensive and science-based risk assessment. This risk assessment (RA) is performed by applicants and then evaluated by national authorities in close cooperation with the European Food Safety Authority (EFSA). The EFSA Panel on Genetically Modified Organisms (GMO) has published a comprehensive set of guidance documents for applicants and risk assessors for the RA of GM plants (GMP), their products for food and/or feed use, and their cultivation. In those documents, the strategy and the criteria to conduct the assessment are explained, as well as the scientific data to be provided by the applicant. The assessment starts with the molecular characterisation of the GMP. If the GMP or products derived from it are to be consumed, the evaluation of its composition, potential toxicity and/or allergenicity, and nutritional value constitute further cornerstones of the process. The environmental risk assessment (ERA) considers biotic and abiotic interactions and the impacts of the management of the GM plant when it is intended for cultivation. In the case of GM trees special emphasis would be placed on assessing their characteristic features such as their longevity, ability to disperse and their ecological significance in a range of environments. The outcome of the assessment is reflected in a published opinion from the EFSA GMO panel that indicates whether the GMP and its products raise any safety issues. This scientific opinion constitutes one of the elements taken into account by the different European regulatory authorities prior to a decision regarding authorisation to commercialise the product. |
URI: | http://hdl.handle.net/10037/6332 |
Abstract: | Metridium senile, Halocynthia pyriformis and ParaParastichopus tremulus were subjected to organic and aqueous extraction. The aqueous extract was made with water, while the organic was made with dichloromethane and methanol in 1:1 ratio. The aqueous and organic extracts were fractionated on reversed-phase HPLC and tested for antiviral activity against Herpes simplex virus-1. All the three organisms displayed anti-viral activity in the primary screening, but when retested their activity were lost. During the work with the thesis Dendrodoa aggregata was included.Screening of D.aggregata had shown that deoxytubastrine had antiviral activity in pilot studies. Tubasterine has shown antiviral activity in earlier studies so it was decided to purify and test deoxytubastrine against HSV-1. Analysis on LC-MS ESI-TOF in positive mode indicated the active compound with m/z 178.0906 amu which gave us the elemental composition C9H11N30. The identity of deoxytubastrine was confirmed by LC-MS ESI-TOF in positive mode and 1H-NMR. However, pure deoxytubastrine did not show any pronounced anti-viral activity. |
URI: | http://hdl.handle.net/10037/4390 |
Abstract: | Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today's drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types of mucoadhesive liposomes, namely the chitosan-coated liposomes and chitosan-containing liposomes, where chitosan is both embedded and surface-available, were made of soy phosphatidylcholine with entrapped fluorescence markers of two molecular weights, FITC-dextran 4000 and 20,000, respectively. Both liposomal types were characterized for their size distribution, zeta potential, entrapment efficiency and the in vitro release profile, and compared to plain liposomes. The proof of chitosan being both surface-available as well as embedded into the liposomes in the chitosan-containing liposomes was found. The capability of the surface-available chitosan to interact with the model porcine mucin was confirmed for both chitosan-containing and chitosan-coated liposomes implying potential mucoadhesive behavior. Chitosan-containing liposomes were shown to be superior in respect to the simplicity of preparation, FITC-dextran load, mucoadhesiveness and in vitro |
URI: | http://hdl.handle.net/10037/7003 |
Abstract: | Calanus finmarchicus is a vast resource that until recently have been exploited to a minimal degree only. In the last few years harvesting and processing methods have been developed. There is a large market and great interest in products derived from marine oils. Most of the products today are derived from organisms at a high trophic level, i.e. products derived from cod liver oil. One disadvantage with these products is high levels of fat-soluble pollutants that require extensive purification before the products can be released to the market. As C. finmarchicus exists on the first trophic levels it is not polluted and is therefore very interesting as a substitution for cod liver oil, which is the main source for ω-3 fatty acids. In addition to this studies have shown that the oil extracted from the animal, Calanus oil, have beneficial properties and can reduce the risk for coronary heart disease, cancer and inflammation and this could be attributed to the contents of wax esters, high levels of a natural antioxidant, Astaxantine, and high levels of phytosterols. The aim of this thesis was to isolate and characterize the wax esters of the oil, and elucidate their structure. The wax esters were first separated from the Calanus oil with silica SPE and then transesterified to FAME and FAL. The two structures types were separated into two fractions with APS SPE. The FAME were analyzed as their picolinyl esters in GC-MS for structure elucidation and the FAL as their nicotinate esters and TMS ethers. The fractions from various SPE columns were tested by use of TLC and/or GC-MS to confirm that they contained the actual compounds. The FAME found were in a range of 14 to 22 carbon chain length, and there were saturated, monounsaturated and polyunsaturated FAME present. The PUFA were 18:4 (n-5, 7, 9, 11) and 22:5 (n-5, 7, 9, 11, 13). The FAL identified ranged from 16 to 22 carbon atoms in chain length, and were mostly monounsaturated, but one saturated compound was found. The next step would now be to analyze the wax esters in LC-MS to find the complete structure using the pieces of structure found in the FAME and FAL, as there are limited numbers of combinations of the FAME and FAL in a wax ester. |
URI: | http://hdl.handle.net/10037/3526 |
Abstract: | Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. The pectin- and chitosan-containing liposomes, namely pectosomes and chitosomes, were prepared by the modified solvent injection method. In order to optimize this novel delivery system, we used pectins and chitosans of both high and low degree of esterification/deacetylation (DE/DD), respectively. Sonication was applied to reduce the original vesicle size. All vesicles were characterized for their size, zeta potential, metronidazole entrapment, and stability. Both pectosomes and chitosomes were found to entrap more metronidazole than conventional plain liposomes. Preliminary data indicate that the polymer is present on the liposomal surface, embedded within inner liposomal bilayers, and entrapped inside the aqueous compartment. The next step in the evaluation of this system is the testing of its mucoadhesiveness. |
URI: | http://hdl.handle.net/10037/5590 |
Abstract: | Background: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant condition characterized by the appearance of hundreds to thousands of adenomatous polyps throughout the colon and rectum. If the condition is left untreated it will ultimately develop into colorectal cancer. Most of the articles available today concerning FAP focus on the adenomatous polyposis coli gene as this gene appears to be the most frequent mutated gene in FAP patients. Recent studies suggest that certain modifier genes may play an important role in the development of colorectal cancer in the general population this may also be true for FAP. Aim of the study: The aim of this study was to examine 199 Australian APC mutation positive FAP patients with a molecular diagnosis of FAP for polymorphisms in five loci on chromosomes 10p14, 8q23.3, 8q24, 11q23, 18q21 and the gene ATP5a1. Methods: The genotypes were determined for each individual by finding the polymorphic combination for the candidate single nucleotide polymorphisms (SNPs). When a genotype was determined for a particular DNA sample, the nucleotide present at the polymorpic site was reported. The results were analysed using statistical programs. Results: The result of this study revealed that there is an increased risk of developing polyps if a patient harbours the heterozygote or variant genotype of the SNP rs10318 compared to patients with the wildtype genotype. This appears to be a protective effect against early polyp development in FAP individuals who harbours the variant genotype of SNP rs3802842 compared with those with a wildtype or heterozygote genotype. Patients harbouring the variant genotype of the SNP rs4779584 have an increased risk of developing polyps and CRC at an earlier stage than patients harbouring a wildtype or heterozygote genotype. Conclusion: In conclusions the findings from this study indicate that modifier genes have an effect on disease expression in FAP patients. These results warrant further investigation in larger FAP populations that harbour APC mutations to confirm the associations reported herein. |
URI: | http://hdl.handle.net/10037/2205 |
Abstract: | SAMMENDRAG CXCR4 er en kjemokinreseptor som er involvert i en rekke biologiske prosesser i kroppen, blant annet angiogenese, neurogenese og dannelse av blodceller i embryostadiet. I voksne er CXCR4 funnet å være involvert i sykdommer som HIV, reumatoid artritt og kreft. I litteraturen finnes det potente CXCR4 antagonister (AMD3100, KRH1636, FC131) som har vist effekt mot HIV-1, reumatoid artritt og kreft. Cyklopentapeptidet FC131 er av de mest potente og har vist høy anti-HIV-1 aktivitet. FC131 inneholder to aminosyrer (Arg3 og 2-Nal4) som er helt avgjørende for antagonistisk aktivitet. I denne oppgaven har det blitt syntetisert analoger av FC131, der 2-Nal4 har blitt byttet ut med andre aromatiske aminosyrer for å studere struktur-aktivitets-sammenhengen. Valg av nye aminosyrer har basert seg på egenskaper til den aromatiske naftylgruppen i KRH1636 og FC131. |
URI: | http://hdl.handle.net/10037/2176 |
Abstract: | Studies have shown that fatty acids from fish and fish oils, like eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA) may have a beneficial role in cancer by inhibiting proliferation or inducing apoptosis of the cancer cells. Several mechanisms involving different metabolites (eicosanoids) of the fatty acids have been suggested for the anti-cancer actions, but the detailed effects are still not known. One of the eicosanoid groups of the fatty acids are epoxy-EPAs. Little have been investigated about epoxy-EPAs' effect on cancer cells. This experiment is based on previous studies from this laboratory that have shown an anti-proliferative effect of epoxy-EPA on murine endothelial cells (unpublished data). In this study the effect of 8,9-epoxy-EPA was tested on human breast cancer cell line MDA-MB-231. The epoxide was tested alone and in combination with an epoxide hydrolase inhibitor, N'N-dicycyclohexylurea (DCU). Different cell viability assays were assessed to investigate the effect of 8,9-epoxy-EPA on cancer cell proliferation. Cell cycle and immunoblotting were carried out to test if cell cycle regulatory proteins were affected. 8,9-epoxy-EPA was found to increase cell viability of MDA-MB-231. No change in cell cycle regulatory proteins was found. 8,9-epoxy-EPA was also tested on the MDA-MB-231 cells together with a well known anti-cancer drug, paclitaxel. Cell viability assay and cell cycle analysis were assessed. An increase in cell viability of cell treated with both 8,9-epoxy-EPA and paclitaxel compared to cell treated with paclitaxel alone was found. No effect of 8,9-epoxy-EPA on cell cycle was observed. Results from these experiments are not what we expected based on previous studies. Further studies on cell mechanism and apoptosis are required to investigate possible differences in cell response to epoxide n-3 fatty acids. |
URI: | http://hdl.handle.net/10037/1572 |
Abstract: | Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer's disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer. |
URI: | http://hdl.handle.net/10037/3877 |
Abstract: | Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate the low molecular weight part (< 10 kDa) of ES products from the dog hookworm Ancylostoma caninum and test their activity in a mouse colitis model that resembles human Crohn's disease. The results were inconclusive, but trends could be seen and it seems that two fractions might show activity in the future if the tests are scaled up. The second aim was to use Fmoc-SPPS to synthesise two disulfide-rich peptides that were identified in the transcriptome of hookworms. These peptides possess the cysteine framework of the sea anemone toxin ShK, which is able to block voltage-gated potassium channels. One peptide, Name2, was synthesised successfully and as predicted folded into a ShK-like domain as confirmed by NMR spectroscopy. The three dimensional structure of the peptide was determined and it was revealed to contain two helical segments that were braced by the three disulfide bonds. Difficulties were encountered in the synthesis of Acan1 and the correct peptide was not obtained. |
URI: | http://hdl.handle.net/10037/4321 |
Abstract: | Introduction The Edinburgh IMPACT (Improved Anticipatory Care and Treatment) is aimed at people with long term conditions, and focuses on improving patients' quality of life and reducing preventable hospital admissions. The service is nurse led, and recently primary care pharmacists have been added to the team to perform a medication review pilot. Patients would be referred to the pharmacist, who would go to their house and review their medicines. The aim for this project was to assess pharmaceutical care needs of patients with heart failure, design a clinical document for the use in the care of these patients, and to develop a questionnaire to evaluate the medication review service. Methods A model of pharmaceutical care was adapted from a previous project, and was modified in order to show the multidisciplinary care for patients with heart failure. A pharmaceutical care plan for heart failure was developed by using a pharmaceutical care plan from previous work done on diabetes. A patient questionnaire with closed-ended questions was designed in order to evaluate the existing anticipatory care service. The draft care plan was revised following feedback from pharmacists in NHS Lothian. The draft patient questionnaire was piloted in two patients that had been seen by the pharmacist. Results The output from the project was a tool kit for documentation of the anticipatory care service to heart failure patients. The toolkit comprises; a model of care for heart failure, a two page clinical document (patient profile and care plan) that can be used in the care of patients with heart failure, and a patient questionnaire that enables other to evaluate the anticipatory care service when it is up and running properly. Conclusion The researcher has developed a set of tools that after some redesign and modifications can be used to support the care of patients with heart failure, and to evaluate the medication review service. |
URI: | http://hdl.handle.net/10037/2179 |
Abstract: | Trauma to the skin in the form of severe wound, particularly burns, can facilitate colonization of potentially life threatening bacterial infections. To prevent infections of the wounded area, antimicrobial agents are recommended as standard treatment. Topical administration of antimicrobial agents, such as mupirocin, can provide local therapy, while avoiding the risks of systemic administration. Mupirocin-in-liposomes-in hydrogels were proposed as advanced delivery system for this purpose. Up to now, no liposomal mupirocin for topical administration has been reported. Chitosan was selected as hydrogel matrix due to its biodegradability and in-built antimicrobial and wound healing potentials. Phosphatidylcholine liposomes containing mupirocin, namely non-sonicated and sonicated liposomes, were characterized for vesicle size and size distributions. Non-sonicated vesicles entrapped in average 74 and sonicated 49 % of mupirocin calcium, respectively. Sonication reduced the original vesicle size from around 1 micron down to 135 nm. Liposomes (10 %, w/w) were incorporated in chitosan hydrogels and liposomal hydrogels evaluated for their textural properties. Hydrogels were found to exhibit satisfactory adhesiveness and cohesiveness, with corresponding stability profile. Microbiological assessment confirmed antibacterial properties of liposomally entrapped mupirocin incorporated in hydrogels. In vitro and ex vivo (on pig skin) drug release profiles of various formulations containing mupirocin were performed on Franz diffusion cells. Liposomal hydrogels were compared with marketed mupirocin product, Bactroban® cream. The release studies showed that liposomal size affects the release of the incorporated drug. Liposomal hydrogels were shown to provide sustained release of incorporated mupirocin. In conclusion, liposomal hydrogels developed for mupirocin offer the potential to increase retention time and provide sustained release of a drug, which are important parameters for improved treatment of wounds, including burns. |
URI: | http://hdl.handle.net/10037/3689 |
Abstract: | Background Hereditary non-polyposis colorectal cancer(HNPCC) is an autosomal dominantly inherited predisposition to a variety of epithelial malignancies most notable colorectal and endometrial cancer. Unlike other genetic predispositions to colorectal cancer HNPCC does not present with a premalignant phenotype, which as such makes it difficult to predict when or if an affected person will present with disease. The genetic basis of HNPCC has been conclusively shown to be due to mutations in genes involved in DNA mismatch repair; hMLH1, hMSH2 hMSH6 and PMS2. Methods Several reports suggest that genetic modifiers of disease risk are capable of influencing the age of disease onset in HNPCC and it is likely that many of them have not yet been identified. Recently several genome-wide association studies have revealed a number of colorectal cancer susceptibility loci on chromosomes 10p14, 8q23.3, 8q24, 11q23 and 18q21. These loci are of particular importance as they are associated with an increased risk of colorectal cancer and may therefore act as modifiers of disease risk in individuals diagnosed with HNPCC. Materials and methods 373 Australian and 311 Polish HNPCC patients with a molecular diagnosis of HNPCC have been examined for nine polymorphisms in the five loci described above. All DNA samples were genotyped to determine the allele frequency in the nine polymorphisms investigated. A statistically evaluation of the exact nature of the effect on disease risk was assessed using the statistical software package SPSS Graduate Pack Version 12.0. Results In this study, hMLH1 mutation carriers harbouring the variant genotype for polymorphism rs3802842 were associated to development of colorectal cancer (CRC) at an earlier age than hMLH1 carriers harbouring the heterozygous or wild type genotype. This suggests that the particular polymorphism might act as a modifier for disease development in hMLH1 mutation carriers. |
URI: | http://hdl.handle.net/10037/2206 |
Abstract: | Bakgrunn: Antibiotikaresistens er i dag blitt et signifikant problem på grunn av vårt misbruk – både overforbruk, underforbruk, feilbruk, manglende compliance, inadekvat dosering og ikke minst en likegyldighet til bruk. For alvorlige infeksjonssykdommer som sepsis kan dette gi dramatiske konsekvenser, da man er avhengig av effektive terapimidler da sykdommen er forbundet med høy morbiditet og mortalitet. Selv om Norge enda er et av de landene hvor resistensproblemet er minst så er det viktig at det tas på alvor, og at terapi følger gitte retningslinjer - blant annet ved sepsis hvor en initial bredspektret empirisk terapi raskest mulig bør endres til mer smalspektret terapi for å redusere risikoen for resistensutvikling. Formål: Formålet med denne studien var å undersøke om diagnostisk informasjon i form av mikrobiologisk bakterieidentifikasjon og resistensbestemmelse førte til endringer av bredspektret empirisk terapi ved bakteriemi. Karakterisering av endringer gjort og behandlingsregimer, og vurdere disse i forhold til gitte retningslinjer utarbeidet ved UNN i 2005 var også et mål med studien. Studien ble utført ved Avdeling for Mikrobiologi og Smittevern ved UNN, og sammenlignet med tilsvarende studie utført ved UNN i 2005 og ved St. Olavs Hospital i 2003. Metode: Studien er en deskriptiv observasjonsstudie basert på retrospektive data. Studiepopulasjonen var pasienter innlagt på UNN og med positive blodkulturer i 2006. Pasientjournaler og mikrobiologiske arbeidsskjemaer ble gjennomgått, og det ble registrert antibiotikabehandling og mikrobiologiske besvarelser for gitte registreringsperioder. Resultater: Av 276 episoder med reell bakteriemi ble det registrert endringer i terapiregimene i 34,1 % av besvarte episoder etter mikroskopifunn, 36,2 % etter preliminær resistensbestemmelse og 12,0 % etter definitiv resistensbestemmelse. Ved mistenkt bakteriemi var monoterapi med cefalosporiner eller kombinasjonsterapi med penicilliner og aminoglykosider mest fremtredende. Etter at mikrobiologiske data forelå bestod behandlingen av episoder med gram negative bakterier i hovedsak av monoterapi med cefalosporiner eller kombinasjonsterapi med enten penicilliner og aminoglykosider eller cefalosporiner og aminoglykosider. Behandlingen av episoder med gram positive bakterier bestod i hovedsak av monoterapi med penicilliner eller kombinasjonsterapi med penicilliner og aminoglykosider. Konklusjon: Resultatene tyder på at mikrobiologiske data hadde innvirkning på valg av antibiotikaregime ved bakteriemi. Det ble benyttet empirisk terapi anbefalt i antibiotikaveilederen i større grad ved UNN i 2006 enn ved UNN i 2002 og St. Olavs Hospital i 2002. Andelen monoterapi økte ved UNN fra 2002 til 2006. Resultatene av studien gir inntrykk av at terapien endret seg i henhold til bakterieidentifikasjon og resistensbestemmelse. |
URI: | http://hdl.handle.net/10037/1583 |
Abstract: | Iron homeostasis is regulated by the interaction between the hormone hepcidin and the iron exporter ferroportin. Hepcidin is a cysteine-rich peptide which is secreted by hepatocytes in response to inflammation, eryhropoietic demand and iron stores. Hepcidin binds to its receptor ferroportin, inducing its internalisation and degradation, thus regulating the export of iron from cells to plasma. One of the aims of this study was to determine the three-dimensional (3D) structure of hepcidin using nuclear magnetic resonance (NMR) spectroscopy. The structure calculated consisted of a β-sheet with a hairpin loop showing a flexible N-terminus. The overall aim of this study was to analyse the interaction between hepcidin and ferroportin. Recently, mutational analysis revealed that hepcidin binds to a 20 residue extracellular loop on ferroportin, called the hepcidin-binding domain (HBD). Techniques including NMR spectroscopy, isothermal titration calorimetry (ITC), circular dichroism (CD) spectroscopy and surface plasmon resonance (SPR) spectroscopy were used. The results from all the assays performed indicate, however, that hepcidin does not bind to the HBD peptide. Three hepcidin analogues was synthesised to elucidate which residues in hepcidin that are important for the binding to ferroportin. The N-terminus of hepcidin is essential for binding to hepcidin and serial deletion of the N-terminal amino acids showed to cause progressive loss of activity when all five residues were deleted. Gly 20 was shown to have a key role in the interaction between hepcidin and ferroportin. This is the first mutation outside the N-terminus region that has activity. |
URI: | http://hdl.handle.net/10037/2178 |
Abstract: | Background Pharmaceutical care as a health care service has already made its mark and been shown to make an important contribution to the health care system. However, there is still a demand from the NHS among others, that pharmacist to a greater extent must document their provision of pharmaceutical care. Tested out in this project, is the application of a Care Issue Categorisation System. Aims To compare two clinical settings in terms of the profile of pharmaceutical care delivered and the profile of medication use. The findings will be reported in a way which allows quantitative comparison of pharmaceutical care issues addressed by the clinical pharmacy service in a proposed reporting, and a modified categorisation system will be use to accomplish this. Method A literature review were performed on pharmaceutical care, medicines management, common chronic diseases etc. Process maps were produced to describe the delivery of pharmaceutical care at the General Medical Ward at Glasgow Royal Infirmary. An existing categorisation system was modified and a guideline developed and both used for the analysis of documentation made by the pharmacists. Inter rater agreement on the categorisation system was tested and pharmaceutical activity was compared between two wards. Result The existing categorisation system was modified in several parts and tested by four investigators. Process maps and analysis of the care issues documented reveal that there was a inconsistency between the pharmacist's provision of care and documentation. The comparison between two wards showed that the pharmacists had different priorities and documentation. Conclusion The modified categorisation system is tool that has the potential to aid future documentation of pharmaceutical provision of patient care. Comparison of pharmaceutical care activity between two ward showed that pharmacists are contribution to pharmaceutical care but that there are differences in their priorities and documentation of care issues |
URI: | http://hdl.handle.net/10037/1573 |
Abstract: | Low levels of glyphosate based herbicide induced significant negative effects on the aquatic invertebrate Daphnia magna. Glyphosate herbicides such as brands of Roundup, are known to be toxic to daphnids. However, published findings on acute toxicity show significant discrepancies and variation across several orders of magnitude. To test the acute effects of both glyphosate and a commercial formulation of Roundup (hereafter Roundup), we conducted a series of exposure experiments with different clones and age-classes of D. magna. The results demonstrated EC50 (48) values in the low ppm-range for Roundup as well as for the active ingredient (a.i.) isopropylamine salt of glyphosate (glyphosate IPA) alone. Roundup showed slightly lower acute toxicity than glyphosate IPA alone, i.e. EC50 values of 3.7–10.6 mg a.i./l, as compared to 1.4–7.2 mg a.i./l for glyphosate IPA. However, in chronic toxicity tests spanning the whole life-cycle, Roundup was more toxic. D. magna was exposed to sublethal nominal concentrations of 0.05, 0.15, 0.45, 1.35 and 4.05 mg a.i./l for 55 days. Significant reduction of juvenile size was observed even in the lowest test concentrations of 0.05 mg a.i./l, for both glyphosate and Roundup. At 0.45 mg a.i./l, growth, fecundity and abortion rate was affected, but only in animals exposed to Roundup. At 1.35 and 4.05 mg a.i./l of both glyphosate and Roundup, significant negative effects were seen on most tested parameters, including mortality. D. magna was adversely affected by a near 100 % abortion rate of eggs and embryonic stages at 1.35 mg a.i./l of Roundup. The results indicate that aquatic invertebrate ecology can be adversely affected by relevant ambient concentrations of this major herbicide. We conclude that glyphosate and Roundup toxicity to aquatic invertebrates have been underestimated and that current European Commission and US EPA toxicity classification of these chemicals need to be revised. |
URI: | http://hdl.handle.net/10037/5971 |
Abstract: | ABSTRACT Epidemiologic studies have indicated that n-3 polyunsaturated fatty acids (PUFAs) supplementation may reduce the incidence of breast cancer, also in vivo and in vitro studies have shown that n-3 PUFAs have an inhibitory effect on breast cancer cells. One important n-3 PUFA are eiocosapentaenoic acid (EPA), which are metabolized to five regioisomeric epoxyeicosatetraenoic acids (epoxy-EPAs) by the cytochromes P450 system. Further, these epoxides are metabolized by epoxide hydrolase (EH), which can be inhibited by N, N`-dicyclohexylurea (DCU), an epoxide hydrolase inhibitor (EHI). The effect of these five epoxy-EPAs and the combination of epoxy-EPAs and EHI on breast cancer cells is not known. In this study the effect of 8, 9-epoxy-EPA on the human estrogen responsive breast cancer cell line MCF-7 was tested. MCF-7 cells were treated with 8, 9-epoxy-EPA, DCU and a combination of 8, 9-epoxy-EPA + DCU. Both the treatment with 8, 9-epoxy-EPA and the combination of 8, 9-epoxy-EPA + DCU inhibited the growth of MCF-7 cells in the presence of FBS. Treatment with 8, 9-epoxy-EPA in the absence of FBS did not result in a change in cell viability, which indicates that the growth inhibition on MCF-7 cells by 8, 9-epoxy-EPA requires an additional proliferative stimulus. To examine the effects of 8, 9-epoxy-EPA on MCF-7 cell growth flow cytometry was used to monitor cell cycle progression. Cells treated with 8, 9-epoxy-EPA and the combination of 8, 9-epoxy-EPA + DCU for 16 and 24 hours were found to be arrested in G0/G1-phase, and did not progress through the cell cycle at the same rate as control cells. 8, 9-epoxy-EPA treatment for 24 hours also resulted in a corresponding decrease in G2/M-phase. The adding of DCU did not enhance the effect of the 8, 9-epoxy-EPA treatment on cell cycle progression significantly. Treatment in the absence of FBS showed no alteration in the progression of the cell cycle. The growth inhibition effect on MCF-7 cells of 8, 9-epoxy-EPA was further studied by examining changes in expression of different cell cycle regulatory proteins. The protein levels were found to be unaltered after 8, 9-epoxy-EPA treatment. The growth inhibition effect may be due to increased cell apoptosis as an alternative to decreased proliferation in MCF-7 cells. This possibility should be evaluated in further studies. |
URI: | http://hdl.handle.net/10037/1574 |
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Us treasury 310 xxva ch33? – yahoo! answers, Best answer: chapter 33 refers to education benefits paid by the va under the post-9/11 gi bill; i would imagine it is probably for the bah payment. check.
What is vaed treas 310 xxva ch33 – the q&a wiki, What is 36 treas 310 misc pay? appears to be payment from va (veteran's affairs) to provider for medical services. what is us treasury 310 xxva benefit?.
What is fsa treas 310 misc pay – the q&a wiki, What is ed treas 310 misc pay? worker. (someone that has lost their job in their known field.) the government pays for the cost. what is 36 treas 310 misc pay?.
Why did i get this check or payment? questions and answers, How do i make a contribution to the u.s. government and how can i return my tax relief payment to the treasury?.
Welcome to the gi bill web site | the home for all educational, Post-9/11 gi bill (chapter 33) payment rates for 2012 academic year (august 1, 2012 – july 31, 2013) for the 2014 academic year rates effective august 1, 2013 click here..
How to identify treasury checks | office of child support, U.s. department of health and human services 370 l'enfant promenade, s.w. washington, d.c. 20447.

subset: commoncrawl


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Edinboro University associate professor, her collaborators win article award
06/13/2013An article by Lenore Barbian, Ph.D., associate professor of anthropology at Edinboro University, and two collaborators received the 2013 best article award from Archivists and Librarians in the History of the Health Sciences (ALHHS).
"Remains of War: Walt Whitman, Civil War Soldiers, and the Legacy of Medical Collections," co-authored by Barbian; Paul Sledzik, M.S.; and Jeffrey S. Reznick, Ph.D., appeared in the January 2012 issue of Museum History Journal.
Through their past work at the National Museum of Health and Medicine, the authors located the anatomical remains of four Civil War soldiers who were among the hundreds of wounded cared for by poet Walt Whitman as a volunteer in the war-era hospitals of Washington, D.C. Their award-winning journal article links the physical remains in the museum's collections with Whitman's descriptions of his experiences with the men.
The article is an outgrowth of a museum exhibit created by Barbian and Reznick that was part of the NMHM's permanent exhibit on Civil War medicine, "To Bind Up the Nation's Wounds." Reznick, now chief of the History of Medicine Division at the National Library of Medicine, is the former Senior Curator at the National Museum of Health and Medicine, where Barbian and Sledzik served as curators of the Anatomical Collections. The museum was created during the Civil War as the U.S. Army Medical Museum.
"To me, at its core, 'Remains of War' is about the re-contextualization of human remains – as medical data (specimens of morbid anatomy), museum specimens, memento mori, and as testimonies to the costs of war," Barbian said.
Barbian, a physical anthropologist with a specialty in skeletal biology, has studied human remains from prehistoric, historic, and forensic contexts. She was part of the Disaster Mortuary Operational Response Team (DMORT) that was deployed to Somerset, Pa., after the Sept. 11, 2001 terrorist attacks to identify the victims of Flight 93.
Prior to coming to Edinboro, Barbian worked at the American Museum of Natural History in New York City as the physical anthropologist for its Native American Graves Protection and Repatriation Act (NAGPRA) compliance activities, then joined the National Museum of Health and Medicine in Washington, D.C., where she worked for 10 years.
Her research interests include forensic anthropology, mortuary behavior, and museology, especially the history of human remains collections.


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Waka Flocka Flame tells Angie Martinez that he doesn't release music that degrades women because of the negative influence it may one day have on his 7-year-old stepdaughter:
"If I degrade women she going to grow up listening to that. If I make it cool to degrade women, she's gong to be like 'Damn, my nigga can degrade me.'"
So ladies, when Waka instructs you to "bounce that ass, shake that ass like the twerk team" he means it in the most empowering way possible. Watch their conversation below. | photo courtesy Billboard


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Brand new 27x40 inch original US One Sheet movie poster of Triumph of the Spirit featuring Willem Dafoe and Edward James Olmos and Robert Loggia
We promise to never spam you, and just use your email address to identify you as a valid customer.
This product hasn't received any reviews yet. Be the first to review this product!
Click the button below to add the TRIUMPH OF THE SPIRIT 500616 ORIGINAL POSTER to your wish list.
All prices are in USD Copyright 2015 The Movie Store. Sitemap | Shopping Cart Software by Bigcommerce


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Voluntary Student Organizations
VSOs can use Oregon State University, Oregon State or OSU in the organizations name and designs. However, the club's name must appear first and be followed by @ or at.
Not Allowed
VSOs cannot use any official university logo in their organization's name, logo, materials or products.


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Fri, Aug 23, 13 at 16:13
I have been in the market for a 30 inch NXR range, and have been watching Costco website for any sales and such. I noticed today that the costco.ca website has some new NXR models. These are BX models and have different burner sizes going up to 15K. It also comes with what looks like the center grate on the 30 inch model, plus a propane conversion kit. Not sure yet if these will be available in the US, or if the existing models will soon be replaced; I have a call into DuroCorp to find out if possible. |
Follow-Up Postings:
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I'm currently completing a new home, should be ready in about 6 weeks. We've stubbed up for a water softener in a closet accessible from the garage. I'd also like to do a whole house carbon filter, and yes I know there are those that advise against it. The house is 4,100 sq ft, 4 full bathes, and it's my wife and I plus our son - and we're expecting our second child so I'd like to size for four (4) people.
I filled a 4.5 gallon bucket in 32 seconds using my master tub. I also had a water test done, here are the results: Copper = 0 ppm
I'm looking at a Fleck based softener and carbon filter, I would of liked to have gone with Kinetico but I prefer to stay in the $1,500 'range' (or less of course). Please make your recommendations - I've read a lot of good info from justalurker on the web so hopefully he will chime in as well. Thanks Gardenweb! |
Follow-Up Postings:
- Posted by aliceinwonderland_id (My Page) on Thu, Nov 15, 12 at 17:50
If you are still looking for advise: A one cuft softener will do nicely for your situation. There are lots of threads on softeners and what to ask for and what to look out for so I won't repeat all of that information here. As to the carbon filter, do I assume correctly that you are on city water and want to remove chlorine? Or are there other contaminants you are concerned about? In order to size it correctly, you need to know what you are removing. Make sure the carbon filter flow rate exceeds the flow into your master tub. Also, DO NOT let any salesperson try to tell you that a mixed bed softener/carbon filter is a good idea. Two separate units should be installed. If you have any other specific questions, I'll keep watching this thread. |
Thanks for your reply, I can't believe how crazy it is to get all the real facts about water softeners and filters to make an informed decision. I've been recommended everything from Kinetico to Culligan, I was hoping to find some consistency in recommendations but they've been all over the map. The most popular has been a 1.5 cu ft Fleck 7000 based softener and a 2.5 cu ft Fleck based carbon filter. Some recommendations as high as 2.0 cu ft on the softener and 3.5 cu ft. on the carbon filter but I think that might be too high. Please let me know what you think about going with a 1.5 cu ft (48k grain) Fleck 7000 based softener and 2.5 cu ft. Fleck 7000 based carbon filter (I know you mentioned only 1 cu ft for the softener). I'd go with the catalytic carbon option in the filter due to the chloramines in the water. What upgrades or options / accessories should I include? Gravel underbed, media upgrade (SST-60?), upgrade brine tank size, upper baskets, noryl vs brass, etc etc etc. Thanks! |
- Posted by aliceinwonderland_id (My Page) on Fri, Nov 16, 12 at 15:16
What size is your plumbing? If 8.4 GPM is the maximum flow you are able to get, you can only use a 13" tank for your carbon filter, which is 2.5 cuft of carbon. If you can get a higher flow rate of 10 gpm, you could go with a 14" tank and up to 3 cuft of carbon. If you get a tank larger than you can successfully backwash, you will run into problems. As to softener size, a one cuft softener will regen every 7-8 days with optimum salt and water efficiency. If you get a 1.5 cuft softener you have to make a compromise. Either you allow it to regen every 12 days which causes more damage to the resin, or you regen every 7 days and spend more money on salt. If you have high-flow fixtures, such as a jacuzzi tub or a multi-head shower, or have frequent guests, it may be worthwhile purchasing the larger softener. You want: 1. Gravel underbed - REQUIRED You asked about: SST-60 resin: This is a great resin, but may be overkill for you. It is fine mesh, 10% crosslinked resin. I would recommend it if you had iron or were not installing a carbon filter since it has good oxidation resistance and works well when a bit of iron removal is required. |
It's 1" PEX stubbed for the softener / filter. Our meter is 5/8" and the builder ran 1-1/4" from the meter to the house. In the house is 1" to the main areas then down to 3/4" or 1/2" to the fixtures depending on flow requirements. I'm not sure how I can get more flow than what I measured at the master tub, I measure at an outside hose bib and the flow was slower there. Is 8.4 GPM relatively slow? I think I'd rather go with 1.5 cu ft and have capacity to handle more demand (understanding I'd be using more salt). Why would somebody recommend a 2.5 Cu. Ft 7000 (13x54 tank) for the softener and setting the override to 30 days? That was recommended to me earlier today. Thanks. |
- Posted by aliceinwonderland_id (My Page) on Fri, Nov 16, 12 at 17:27
Someone would recommend a 2.5 cuft softener because they have the bare minimum training necessary to sell a softener and have not clue one how they work, OR they just want the higher $ sale and will be happy to sell you new resin down the road when it fails earlier than it should. In my experience, most softener sales folks don't know a thing - they sell pretty much the same thing to everyone. |
Thanks again. I'm thinking back to your comments about flow rate and the 8.4 GPM I get at my master tub. How do I get a better idea of what the house's flow rate would be at the carbon filter? Wouldn't it be more than 8.4 GPM since that is just from the master tub? If I turn on other faucets at the same time isn't my overall SFR increasing? |
- Posted by aliceinwonderland_id (My Page) on Sat, Nov 17, 12 at 1:30
If you have a spigot close to the closet where the filters will be located you could measure there. Typically an outside faucet close to where water enters the house will give you a better picture. Or you could try a tub and a shower to see if you actually do get more flow. You might not - some tub faucets will take as much water as you can get there. 8.4 seems a little on the low side, but you may have obstruction somewhere, a valve not entirely open, any number of things. |
- Posted by justalurker (My Page) on Sat, Nov 17, 12 at 2:44
"I filled a 4.5 gallon bucket in 32 seconds" That's 9 gpm allowing for slightly sloppy timing. Not an uncommon SFR in many homes and right on the nose for what a 1 cube softener using standard hi-capacity resin would provide. I would expect a higher SFR for a 4 full bathroom home. You might discuss that with your builder and the plumbing inspector. |
Thank you all for the info. I have a follow up question... would a twin tank softener be of any advantage in my scenario? I find the efficiency aspect appealing (not the 24/7 availability), water is expensive in our neighborhood and the price will be going up more than usual over the next few years (per our newsletter). |
Please Note: Only registered members are able to post messages to this forum. If you are a member, please log in. If you aren't yet a member, join now!
Return to the Plumbing Forum
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- Please review our Rules of Play before posting.
- Posting is a two-step process. Once you have composed your message, you will be taken to the preview page. You will then have a chance to review your post, make changes and upload photos.
- After posting your message, you may need to refresh the forum page in order to see it.
- Before posting copyrighted material, please read about Copyright and Fair Use.
- We have a strict no-advertising policy!
- If you would like to practice posting or uploading photos, please visit our Test forum.
- If you need assistance, please Contact Us and we will be happy to help.
Learn more about in-text links on this page here


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found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
Find a pet to adopt |
My name is Huck Fin!
Facts about Huck Fin
- Breed: Polydactyl/Hemingway
- Color: White (Mostly)
- Age: Kitten
- Sex: Male
- Hair: Medium
Huck Fin's Info...
I am already neutered, in need of an experienced adopter, up to date with shots, not good with kids, good with dogs, and good with cats.
This beautiful boy as rescued from a high kill shelter. He is buff point, and just goureous. He is a little shy with people and will need a calm home with lots of cuddling. He loves other cats and would do well with a playmate or on his own. He does have kitty friends in his foster home and would love to take one of them home with him if you have room for two!
Other Pets at Ernie's Hope
Why Adoption is a Great Option
Huck Fin, a Escondido Polydactyl/Hemingway kitten was adopted! Here's how you can benefit by looking at adoption as an option to buying a Polydactyl/Hemingway for sale in Escondido, or seeking a Polydactyl/Hemingway kitten from a breeder in Escondido.
- Rescues and shelter volunteers in Escondido already know the personality and tendencies of their pets. This means they can match you with the right pet. That will makes it much easier transition to owning a pet for yourself and your new pet.
- On average adoption fees are much less than you'd pay a Escondido breeder, or pet store. Plus most often rescue pets have already been to the veterinarian for a check-up, had a round of vaccinations, and are spayed or neutered. That is a lot of savings!
- You will become a hero, and give a needy dog or cat a loving home. In fact, there are even Polydactyl/Hemingway breeders who help with Polydactyl/Hemingway rescue. One puppy or kitten adopted in Escondido paves the way for another one to be saved.


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Revised Standard Version (RSV) | New International Version (NIV) |
1 There was a certain man of Ramatha'im-zo'phim of the hill country of E'phraim, whose name was Elka'nah the son of Jero'ham, son of Eli'hu, son of Tohu, son of Zuph, an E'phraimite. | 1 There was a certain man from Ramathaim, a Zuphite from the hill country of Ephraim, whose name was Elkanah son of Jeroham, the son of Elihu, the son of Tohu, the son of Zuph, an Ephraimite. |
2 He had two wives; the name of the one was Hannah, and the name of the other Penin'nah. And Penin'nah had children, but Hannah had no children. | 2 He had two wives; one was called Hannah and the other Peninnah. Peninnah had children, but Hannah had none. |
3 Now this man used to go up year by year from his city to worship and to sacrifice to the LORD of hosts at Shiloh, where the two sons of Eli, Hophni and Phin'ehas, were priests of the LORD. | 3 Year after year this man went up from his town to worship and sacrifice to the LORD Almighty at Shiloh, where Hophni and Phinehas, the two sons of Eli, were priests of the LORD. |
4 On the day when Elka'nah sacrificed, he would give portions to Penin'nah his wife and to all her sons and daughters; | 4 Whenever the day came for Elkanah to sacrifice, he would give portions of the meat to his wife Peninnah and to all her sons and daughters. |
5 and, although he loved Hannah, he would give Hannah only one portion, because the LORD had closed her womb. | 5 But to Hannah he gave a double portion because he loved her, and the LORD had closed her womb. |
6 And her rival used to provoke her sorely, to irritate her, because the LORD had closed her womb. | 6 And because the LORD had closed her womb, her rival kept provoking her in order to irritate her. |
7 So it went on year by year; as often as she went up to the house of the LORD, she used to provoke her. Therefore Hannah wept and would not eat. | 7 This went on year after year. Whenever Hannah went up to the house of the LORD, her rival provoked her till she wept and would not eat. |
8 And Elka'nah, her husband, said to her, "Hannah, why do you weep? And why do you not eat? And why is your heart sad? Am I not more to you than ten sons?" | 8 Elkanah her husband would say to her, "Hannah, why are you weeping? Why don't you eat? Why are you downhearted? Don't I mean more to you than ten sons?" |
9 After they had eaten and drunk in Shiloh, Hannah rose. Now Eli the priest was sitting on the seat beside the doorpost of the temple of the LORD. | 9 Once when they had finished eating and drinking in Shiloh, Hannah stood up. Now Eli the priest was sitting on a chair by the doorpost of the LORD's temple. |
10 She was deeply distressed and prayed to the LORD, and wept bitterly. | 10 In bitterness of soul Hannah wept much and prayed to the LORD. |
11 And she vowed a vow and said, "O LORD of hosts, if thou wilt indeed look on the affliction of thy maidservant, and remember me, and not forget thy maidservant, but wilt give to thy maidservant a son, then I will give him to the LORD all the days of his life, and no razor shall touch his head." | 11 And she made a vow, saying, "O LORD Almighty, if you will only look upon your servant's misery and remember me, and not forget your servant but give her a son, then I will give him to the LORD for all the days of his life, and no razor will ever be used on his head." |
12 As she continued praying before the LORD, Eli observed her mouth. | 12 As she kept on praying to the LORD, Eli observed her mouth. |
13 Hannah was speaking in her heart; only her lips moved, and her voice was not heard; therefore Eli took her to be a drunken woman. | 13 Hannah was praying in her heart, and her lips were moving but her voice was not heard. Eli thought she was drunk |
14 And Eli said to her, "How long will you be drunken? Put away your wine from you." | 14 and said to her, "How long will you keep on getting drunk? Get rid of your wine." |
15 But Hannah answered, "No, my lord, I am a woman sorely troubled; I have drunk neither wine nor strong drink, but I have been pouring out my soul before the LORD. | 15 "Not so, my lord," Hannah replied, "I am a woman who is deeply troubled. I have not been drinking wine or beer; I was pouring out my soul to the LORD. |
16 Do not regard your maidservant as a base woman, for all along I have been speaking out of my great anxiety and vexation." | 16 Do not take your servant for a wicked woman; I have been praying here out of my great anguish and grief." |
17 Then Eli answered, "Go in peace, and the God of Israel grant your petition which you have made to him." | 17 Eli answered, "Go in peace, and may the God of Israel grant you what you have asked of him." |
18 And she said, "Let your maidservant find favor in your eyes." Then the woman went her way and ate, and her countenance was no longer sad. | 18 She said, "May your servant find favor in your eyes." Then she went her way and ate something, and her face was no longer downcast. |
19 They rose early in the morning and worshiped before the LORD; then they went back to their house at Ramah. And Elka'nah knew Hannah his wife, and the LORD remembered her; | 19 Early the next morning they arose and worshiped before the LORD and then went back to their home at Ramah. Elkanah lay with Hannah his wife, and the LORD remembered her. |
20 and in due time Hannah conceived and bore a son, and she called his name Samuel, for she said, "I have asked him of the LORD." | 20 So in the course of time Hannah conceived and gave birth to a son. She named him Samuel, saying, "Because I asked the LORD for him." |
21 And the man Elka'nah and all his house went up to offer to the LORD the yearly sacrifice, and to pay his vow. | 21 When the man Elkanah went up with all his family to offer the annual sacrifice to the LORD and to fulfill his vow, |
22 But Hannah did not go up, for she said to her husband, "As soon as the child is weaned, I will bring him, that he may appear in the presence of the LORD, and abide there for ever." | 22 Hannah did not go. She said to her husband, "After the boy is weaned, I will take him and present him before the LORD, and he will live there always." |
23 Elka'nah her husband said to her, "Do what seems best to you, wait until you have weaned him; only, may the LORD establish his word." So the woman remained and nursed her son, until she weaned him. | 23 "Do what seems best to you," Elkanah her husband told her. "Stay here until you have weaned him; only may the LORD make good his word." So the woman stayed at home and nursed her son until she had weaned him. |
24 And when she had weaned him, she took him up with her, along with a three-year-old bull, an ephah of flour, and a skin of wine; and she brought him to the house of the LORD at Shiloh; and the child was young. | 24 After he was weaned, she took the boy with her, young as he was, along with a three-year-old bull, an ephah of flour and a skin of wine, and brought him to the house of the LORD at Shiloh. |
25 Then they slew the bull, and they brought the child to Eli. | 25 When they had slaughtered the bull, they brought the boy to Eli, |
26 And she said, "Oh, my lord! As you live, my lord, I am the woman who was standing here in your presence, praying to the LORD. | 26 and she said to him, "As surely as you live, my lord, I am the woman who stood here beside you praying to the LORD. |
27 For this child I prayed; and the LORD has granted me my petition which I made to him. | 27 I prayed for this child, and the LORD has granted me what I asked of him. |
28 Therefore I have lent him to the LORD; as long as he lives, he is lent to the LORD." And they worshiped the LORD there. | 28 So now I give him to the LORD. For his whole life he will be given over to the LORD." And he worshiped the LORD there. |
Revised Standard Version of the Bible, copyright 1952 [2nd edition, 1971] by the Division of Christian Education of the National Council of the Churches of Christ in the United States of America. Used by permission. All rights reserved. (Revised Standard Version - Holy Bible) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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Auburn Youth Softball
Welcome to the Auburn City Rec. Youth Softball League! For additional information please contact the Softball Commissioner: Aric Harris (402) 274-7937.
2014 Softball sign-up meetings are now complete. If you still wish to sign your daughter up for softball, Auburn City Hall has sign-up forms available. You can also print the form below and drop it at City Hall along with payment. The deadline for sign-up is April 11, 2014.
The age division is determined by your daughter's age on January 1, 2014 in accordance with ASA rules. A copy of your daughter's birth certificate will be requested for tournaments.
Age Divisions:
10 & Under (9 and 10 years of age)
12 & Under (11and 12 years of age)
14 & Under (13 and 14 years of age)
16 & Under and 18 & Under has been combined for league play for the 2014 Season.


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Photo provided by: HNTB Corp.
Dames Point Homepage
Dames Point - picture at night awesome pic
The Dames Point Bridge (also known as the Napoleon Bonaparte Broward Bridge or Dame Point Bridge) spans the St. Johns River northeast of downtown Jacksonville, Florida. Two miles long, and 175 feet above the main channel of the river, the Dames Point Bridge connects northern Jacksonville with the Arlington and Beaches area of east Jacksonville via Florida Highway 9A. Opened to traffic in 1989, it is a premier example of the beautiful simplicity of the cable-stayed bridge.


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found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
Find a pet to adopt |
My name is Jazz!
Facts about Jazz
- Breed: Rottweiler
- Color: Black - With Tan, Yellow Or Fawn
- Age: Adult
- Size: Large 61-100 lbs (28-45 kg)
- Sex: Female
Jazz's Info...
I am already spayed, housetrained, purebred, up to date with shots, good with kids, and good with dogs.
Jazz is approximately 3 years old. She is very good with people of all shapes, sizes and age. She is okay with other dogs. She is a dominant female,. and would do better with a male dog. She does great with small dogs and children. She has been loved like a child her whole life and never abused. Her parents had to move to Africa and unfortunately could not take her or her rotten rottie brother, Ky, with them. She is bonded to her male companion Malachi. She was 6 months old when Ky moved into her home as an 8 week old pup and she has loved him ever since. We would really like to keep her and Ky together if possible. They are a perfect pair of rotten rotties! She is house trained and knows basic obedience. They are inside dogs and will need to remain that way. She walks well on a leash, and doesn't pull at all. She is confident and fearless. She is not destructive, and she listens well. She is also crate trained.
Other Pets at Rotten Rottie Rescue
Why Adoption is a Great Option
Jazz, a Gilbert Rottweiler dog was adopted! Here's how you can benefit by looking at adoption as an option to buying a Rottweiler for sale in Gilbert, or seeking a Rottweiler dog from a breeder in Gilbert.
- Rescues and shelter volunteers in Gilbert already know the personality and tendencies of their pets. This means they can match you with the right pet. That will makes it much easier transition to owning a pet for yourself and your new pet.
- On average adoption fees are much less than you'd pay a Gilbert breeder, or pet store. Plus most often rescue pets have already been to the veterinarian for a check-up, had a round of vaccinations, and are spayed or neutered. That is a lot of savings!
- You will become a hero, and give a needy dog or cat a loving home. In fact, there are even Rottweiler breeders who help with Rottweiler rescue. One puppy or kitten adopted in Gilbert paves the way for another one to be saved.


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Help BCRC Rock the House during Amplify Austin!
We are thrilled to announce BCRC's participation in Amplify Austin's community-wide day of giving starting March 20th at 6pm until March 21st at 6pm!
Amplify Austin is a 24-hour online giving initiative presented by I Live Here I Give Here. Last year, your contributions made BCRC a huge success, raising over $35,000 from donors all across Central Texas and as far away as New York City!! BCRC also spent the entire 24-hour period ranked in the TOP FIVE on Amplify Austin's 2013 Leaderboard - boosting our profile within the Austin community!!
This year we want to come back BIGGER and STRONGER and we need YOUR help to Rock the House!!
Visit www.AmplifyAtx.org/BCRC
How to help BCRC Rock the House!
- Be a Donor – Make your amplify gift to BCRC during the 24 hour giving period (6pm, March 20 to 6pm March 21). Click here to donate!
- Be a BCRC Social Rock Star! – Help us spread the word and encourage your friends and family to participate through Facebook and Twitter! Share our Amplify Austin posts on your Facebook wall, retweet our #AmplifyATX tweets to your Twitter page, and let your followers know why you support BCRC!
Need Social Media Help? Check out our Amplify Austin Social Media Guide for helpful tips!!
Different Ways to Donate
While we encourage you to give you gift during the 24-hour giving-period, funds for BCRC can be raised anytime between February 1st and March 21st at 6pm.
1. Give your gift during one of BCRC's two "power hours" occurring within the 24-hour giving period. BCRC will announce our power hour times one week before via email and social media. This makes us eligible for additional prize money during the campaign. SEE BELOW.
2. Schedule* one-time donation ahead of time - 'set it and forget it'
3. Schedule* automated recurring (daily/weekly/monthly/quarterly) donations for a specific amount
*NOTE: Scheduled gifts help BCRC be in the running for the $5,000 "Drum Solo" grand prize, but do NOT count toward BCRC's chance to win an hourly $1000 "Bass Booster" prize.
Every dollar you donate to BCRC through www.AmplifyATX.org/bcrc during this 24-hour period becomes almost two dollars! Your gift to BCRC will be amplified by incentive matching dollars from Amplify Austin's generous sponsors, AND the St. David's Foundation is once again providing an additional match of $.50 for every dollar we raise up to $150,000.
Only funds donated from March 20 (6pm) to March 21 (6pm) will qualify for the incentive pool and prizes. Listed below are the different ways your donations during the 24-hour giving period will help us raise more money and drive BCRC to the top of the AmplifyATX Leaderboard!
4 "Drum Solo" Grand Prizes
- $5,000 for the nonprofit with the most dollars raised during the 6-hour period from 6pm, March 20 - Midnight March 21.
- $5,000 for the nonprofit with the most donations from unique Amplify Austin donors during the entire 24 hour event
- $5,000 for the nonprofit with the most total dollars raised during the entire 24 hour Amplify Austin event
48 "Bass Booster" Prizes (2 prizes awarded every hour on Amplify Austin)
- $1,000 will be awarded to the nonprofit with the most unique donors every hour during Amplify Austin
- $1,000 will be awarded to the nonprofit that raises the most dollars every hour during Amplify Austin


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Fighting poverty and ensuring access to basic services
Urban poverty and spatial segregation
As they develop and become wealthier, cities - the drivers of economic growth - are seeing inequalities and poverty gain headway within their borders. It is estimated that already one-third of the world's citizens live in shantytowns (70% in Africa) deprived of the most essential urban services: drinking water, sanitation, waste collection and transport.
Also visible, in all of the world's cities, is increasing spatial and social fragmentation. Even as they expand and globalise, cities are fragmenting into specialised territories, obeying a differentiation process that is both functional and social, with the best-equipped urban territories tending to step away from the underprivileged neighbourhoods, and even from their local environment. In the South, urban sprawl tends to come with greater instability for underprivileged populations, in particular in terms of access to land. In the shantytowns, the populations are also the most exposed to both the natural and health risks generated by the deterioration of the environment, pollution in the waterways, water tables and air.
Supporting delivery for basic services
The fight against poverty, access to all basic services and sustainable economic and social development are, in an environment where the socio-economic, health-related and environmental issues are treated jointly, priorities for French Cooperation toward attaining the Millennium Development Goals (MDGs).
One major challenge which the Southern cities must take up lies in delivery of basic services to the entire population, and in particular to informal settlement neighbourhoods.
With this in mind the Ministry of Foreign and European Affairs encourages the mobilisation of local resources, as well as the involvement of the private sector and civil society in the public institutions, through innovative partnerships. Public action at the State and local levels must provide leverage, in particular through the virtuous circle of tax policy, to guide investments and partnerships with private players toward the fight against poverty. However, beyond the financial resources and technical considerations, the main challenge in implementing basic services lies in establishing dialogue between national institutions, local powers, service providers and the populations around a shared, long-term project. That implementation process bears upon the responsibility of the public authorities, as guarantors of general interest.


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''In each of us there are two natures,'' whispers a disembodied voice in the prologue to Frank Wildhorn's Jekyll & Hyde. Good and evil the ''primitive duality of man,'' he continues (there quoting directly from Robert Louis Stevenson's 1886 novella The Strange Case of Dr. Jekyll & Mr. Hyde). ''It is the curse of mankind that these polar twins should be constantly struggling.''
The same could be said of the 1997 musical itself, now receiving an overamplified, dry ice-drenched Broadway revival following a national tour: It's good and well, not evil, but head-scratchingly, laughably, even painfully bad. And one that you'll be constantly struggling to sit through.
As the titular schizophrenic scientist, American Idol alum Constantine Maroulis a 2009 Tony nominee for his turn in the '80s jukebox show Rock of Ages supplies hair-band-worthy locks and lungs of steel. His ''This Is the Moment'' (the 11 o'clock number that comes 45 minutes in) is indeed momentous a triumph of vocal pyrotechnics over clichéd phrases, misaccented lyrics, and throat-testing key changes. He also supplies an accent that travels the whole of the United Kingdom.
Playing Jekyll's clueless well-bred fiancée, Emma, Teal Wicks adopts an odd Lady Mary intonation and an unnecessarily competitive singing style that emerges during the show's treacly but immensely popular duet ''In His Eyes.'' Unfortunately for Wicks, R&B songstress Deborah Cox wins the belting match without breaking a sweat. In fact, Cox as Lucy, the hooker with the heart of gold and bustier of steel is quite terrific throughout. She even manages to make that ubiquitous cabaret tune/power ballad ''A New Life'' audible over the stadium-level orchestrations.
Oh yes, the tunes: Wildhorn has written some darn good ones. And they'll get lodged in your head so firmly that you'll need ''It's a Small World'' to clear them out. But, oh, the lyrics! Example: ''You've not heard/A single word I've said/My fear is he's in over his head!'' And in the song ''Murder'': ''Another murder! Just like that other murder!'' (Wildhorn and Steven Cuden share, ahem, credit for those particular gems with Leslie Bricusse.) Perhaps that's why the music is amplified to eardrum-splitting levels!
But there are so many puzzlements in this production, which is both over- and under-directed by Jeff Calhoun (whose credits include last season's Disney hit Newsies and Wildhorn flop Bonnie & Clyde). There are Maroulis' mutton chops, which threaten to take over his entire face; the choreography in Cox's bordello-set ''Bring On the Men'' an S&M-inspired, quasi-Cabaret, rope-swirling maypole-esque mess; and the ''Confrontation'' between Jekyll and Hyde, the song that's both a solo and a duet. I won't give away the trick, but Maroulis isn't doing the hair-tossing thing that Robert Cuccioli (and Sebastian Bach and Jack Wagner and David Hasselhoff) did in the original production. Calhoun came up with a good idea which then went terribly, terribly wrong. It is, I think, the curse of Jekyll & Hyde. C–
(Tickets: Ticketmaster.com or 800-745-3000)


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Posts: 4,331
Joined 21-Aug-09
Not the best photo, but i love these pj's i picked up for El and i made her headband and bow:) She's my Christmas baby
www.ourmicrosortstory.blogspot.com www.newbornlovenursery.blogspot.com
Posts: 1,342
Joined 7-Mar-10
Yes and yes:) I am going to search for them! I love photos
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Joined 4-May-10
Goodness she is precious! I wish I knew how to make bows, I have tried and failed miserably. LOL
Me(29)DH(28) & our little clan 9/22/00 5/8/2007 1/20/2009 and 9/20/2010
DH says we are done, but I will always dream of more!
Posts: 476
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Oh she is just beautiful! and adorable pj's and i love the headband!
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Joined 13-Mar-09
Gold Membership
Awww she is so cute.. love her expression Great job on the headband too!!
It's not my children's job to make ME happy, It's MY job to make THEM happy


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An innovative new car washing system which uses just half a litre of water per car has been installed at White River Place shopping centre, St Austell.
The car wash, located on the ground floor level of the White River Place car park, is operated by Plymouth-based company 2G Services Ltd and opened earlier this month. White River Place is currently the only site in Cornwall offering the eco-friendly car washing service, which uses a bespoke low mist vehicle washing system to drastically reduce the amount of water needed to clean the cars. According to the International Car Washing Association, a DIY hand car wash or a self service car wash uses on average 100 litres of water per vehicle – meaning that the 0.5 litres used by 2G Services is a 99.5 per cent reduction on the traditional methods. The unique mist cleaning method ensures that no water or waste reaches the ground, which in addition to reducing the amount of water used also prevents pollution from gasoline, oil and residues from exhaust fumes washed off the car entering waterways and causing damage to the eco-system. The car wash operates a drop off and collect service, which means shoppers can leave their cars to be washed while they shop, and collect them when they're ready to leave. Claire Daniel, White River Place Centre Manager said: "The new car wash is absolutely fantastic – you would never believe that you could get such a perfectly clean, glistening finishing using just half a litre of water but it really does work. Since slashing the parking prices earlier in the year the White River car park has been incredibly busy, and the introduction of the car wash is a great example of how we are trying to improve the experience for shoppers by offering extra services that they won't find elsewhere." Alan Beal, Managing Director of 2G Services added: "I'd like to thank Claire and all the team at White River Place for helping us to get settled in and promoting the car wash. The reaction we've had from shoppers so far has been fantastic – you really do need to try it for yourself to see just how efficient our eco-friendly system is." Car washes at White River Place are available from £6 per car, on the lower level of the car park. For more information about White River Place visit www.whiteriverplace.co.uk or follow us on Twitter @whiteriverplace or find us on Facebook. Ends Download full press release


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Blog | Comments |
WoW | 6 Comments |
Recent Comments:
Sleeper Cartel holds their Summer party (and Horde Diplomacy) {WoW}
Jul 21st 2008 2:53PM you have "June 27th" for the speeches
Forum menus tweaked, cleaner and easier to browse {WoW}
May 15th 2008 6:35PM old news
Scattered Shots: Hunter problems and predictions {WoW}
May 15th 2008 6:32PM Enhancement shamans are not a class... Blizzard has stated that they want to make at least 1 spec Arena viable for every class, enhancement is not the Shaman's. The problem with Hunters is that MM is our "Arena spec" and Blizzard's own arena representation numbers show that Hunters aren't really viable in Arena at all.
WoWWiki levels up {WoW}
May 15th 2008 6:30PM This is so last month...
Scattered Shots: Hunter problems and predictions {WoW}
May 15th 2008 6:25PM Your insight on the Hunter class is trash at best, stop writing about them.
Enter to win a $5k Dell WoW Edition notebook {WoW}
Dec 14th 2007 2:10PM Application for Horde


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The Spirit of France since 1805. In 1805, Henri-Louis PERNOD first created what was to become the most celebrated spirit on the cafe terraces of 19th Century Paris. Many famous artists, painters, poets and writers discovered its charms and their works included several references to their taste for this new aperitif. The secret of PERNOD's unique taste is well kept, but its flavour is derived from a distillation of star anise and aromatic plants and herbs.
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The seminar business is big these days, in demand by individual consumers, organizations, associations, small businesses and giant corporations alike. And although it's a fairly young industry, having only come into its own within the last two decades, it's primed for continued growth and success.
What's Inside
- Introduction
- Target Market
- Startup Costs
- Operations
- Finding Presenters
- Income and Billing
- Marketing
- Resources
More articles on import/export businesses »
Every year, hundreds of thousands of people pay to attend meetings, seminars, workshops and training programs where professional presenters encourage, enlighten and enliven them. Some of these folks are sent by their companies to learn new skills--everything from time management to basic math smarts to super sales techniques. Others attend on their own, seeking personal growth--how to communicate better with spouses, significant others and kids; manage stress; assert themselves; or invest for the future. Still others sign up for seminars and workshops as part of a professional or social association to learn everything from quilting to romance writing to tax preparation.
Operating Modes
As a seminar professional, you can choose from among three different operating modes. You can:
1. act as a speaker, trainer or presenter, working directly with your audiences and booking your programs on your own or through a speakers bureau (which is sort of like a talent agency)
2. act as a promoter, seminar company or training firm, setting up programs and engaging other people to do the speaking, training or presenting
3. do both, setting up programs at which you present and at which you also bring others on board to share the speaking or training chores
Most seminar professionals choose the first option, but you can go with any one that feels comfortable to you.
Do You Have What It Takes?
Not everybody is cut out to be a seminar production professional. This is not, for example, a career for the creativity-challenged. It takes lots of foresight to figure out what will be a winning program, to design and construct it so it sells, and to promote it effectively. If you're one of those folks who'd rather undergo a root canal than have to come up with peppy advertising copy, then you don't want to be in the seminar business.
This is also not a career for the time-management-deficient. Seminars must be planned and organized months in advance, with everything from the topic and speaker to the dining reservations nailed down early on.
And if you plan on presenting your own programs, this isn't--obviously--a career for the terminally shy or the terminally boring. You must be able to keep an audience interested and entertained for the length of your seminar and beyond. This doesn't mean you need to be trained by both the Royal Shakespeare Academy and the Ringling Brothers Circus school, just that you need to have a natural enthusiasm for your subjects and be able to communicate it.


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Job Description
We are currently looking for a Plant Manager to join our team.
To lead the plant's manufacturing team to produce the highest quality product at the in the most efficient manner possible, while operating the plant in compliance with all Pavestone policies and procedures. The Plant Manager is the direct representative of the General Manager in the manufacturing facility. He also works with the General Manager to establish production schedules, review maintenance issues, and production personnel readiness. Additionally, he is responsible for: 1) All aspects of production including: • Continuous improvement in product quality, including periodic product testing. • Maintaining the highest condition of equipment readiness, plant cleanliness and storage, and production line efficiency. • Maintaining an adequate inventories to satisfy sales volumes • Working closely with the Plant Maintenance Manager regarding all maintenance issues and scheduling preventive and corrective maintenance. 2) All aspects of the plant personnel's proficiency in equipment operations, maintenance, and adherence to company policies including: • Schedule production shifts in order to meet the required production schedule. • Training all operators and shifts to improve their level of knowledge and proficiency of machine operations and safety. • Conducts the weekly safety meetings. • Coordinating with the General Manager to screen, test, hire, and terminate plant personnel. • Performing employees evaluations and setting employee goals. Knowledge, Skills and Abilities:
• Willingness and ability to learn how to operate machinery and equipment.
• Demonstrated history of working in a team oriented environment with excellent written and verbal communication skills • Positive "can do" attitude and ability to motivate team. • Self-starter. Able to work independently, plan, prioritize, coordinate, delegate, manage and complete work. • Proficient basic mathematical skills. • Able to analyze problem circumstances, solve problems, and give direction regarding problem resolution in an expeditious fashion. • Possesses effective time management skills. Able to "switch gears" between tasks without losing focus. • Proficient in a variety of PC-based software applications. • Operate a motor vehicle and possess a valid driver's license and a satisfactory driving record.
• Must be able to read, understand and write general business communication. • Give and receive detailed information through verbal and written communication. Spanish speaking a plus. |
Pavestone |


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- Feb 6:
- SMART, Greenbrae bike improvements, third lane on the Richmond-San Rafael Bridge in line for $110 million
- Dec 2:
- Marin Voice: New Marin freeway connector is critical
- Oct 22:
- Editorial: Highway 101 plan is a missed opportunity
- Oct 2:
- Dick Spotswood: Highway 101 bypassed in plans for traffic improvements
- Sep 27:
- County to spend $39.6 million on Greenbrae bicycle improvements, give $11.4 million to SMART
- County adopts $39.6 million Greenbrae interchange plan, gives $11.4 million to SMART
- Sep 25:
- Dick Spotswood: TAM chief's unusual timing on Highway 101 plan
- Sep 23:
- County to receive Greenbrae interchange working group proposals
- Sep 14:
- Marin Voice: No easy solutions for Greenbrae stretch of Highway 101
- Sep 6:
- Marin Voice: TAM needs to focus on connectivity, not just cars
- Aug 31:
- Dick Spotswood: Headway in finding agreement on Highway 101 plan
- Aug 29:
- Editorial: Highway 101 planning deserves a little more time
- Aug 26:
- Greenbrae interchange group reaches consensus on Hwy. 101 improvements
- Aug 21:
- Greenbrae interchange group discusses northbound lanes, has one meeting left
- Jul 24:
- Editorial: Highway 101 planning deserves more time
- Jul 23:
- Dick Spotswood: Is Highway 101 plan at a dead end?
- Greenbrae interchange group eyes southbound lanes, plans more meetings
- Jul 21:
- Greenbrae interchange working group members irked by lost meeting time
- Marin Voice: Marin has plenty of needs for bridge toll revenue
- Jul 12:
- Marin Voice: Time to change course on 101
- Jun 19:
- Editorial: TAM should give 101 ideas a fair shake
- Jun 18:
- Marin Voice: A less massive solution for Highway 101
- Jun 12:
- Group racks up $248,000 tab assessing options for Larkspur-Corte Madera stretch of Highway 101
- Jun 10:
- Public pitches ideas for improving Larkspur-Corte Madera stretch of Highway 101
- Jun 8:
- Citizens group creates plan for Larkspur-Corte Madera stretch of Highway 101
- Jun 2:
- Marin Voice: Priorities and challenges facing Highway 101 plan
- May 7:
- Marin Voice: Improving the Greenbrae/Highway 101 interchange plan
- Apr 30:
- Marin Voice: TAM should listen to the public on Twin Cities 101 plan
- Apr 14:
- Dick Spotswood: Who's really driving the Highway 101 plan?
- Apr 8:
- Greenbrae interchange working group focuses on Sir Francis Drake Boulevard
- Mar 25:
- Greenbrae interchange working group works on leadership 'trust issue'
- Mar 7:
- Marin Voice: Green opportunity for the Highway 101 project
- Mar 1:
- Dick Spotswood: Time to scale back proposed 101 project
- Feb 22:
- Larkspur demands new environmental plan for Highway 101 project
- Feb 15:
- Marin Voice: Some other options for 101 interchange
- Feb 12:
- Corte Madera demands new environmental plan for Highway 101 project
- Editorial: Faulty crash numbers latest stumble for Marin interchange project
- Feb 6:
- Dick Spotswood: Caltrans needs to do a full EIR for 101 project in Marin
- Feb 5:
- Officials call for committee to review Hwy. 101 interchange project
- Feb 1:
- George Russell: 101 interchange plans
THE SEARCH FOR possible alternatives to the proposed Larkspur-Corte Madera Highway 101 project got off to a bumpy start.
That is not surprising given the lack of trust and political collaboration that has gotten this debate to this point.
After the Larkspur City Council and Corte Madera Town Council rejected the plan designed and pushed by the Transportation Authority of Marin, officials decided to form a special working group to consider possible alternatives.
Larkspur and Corte Madera officials have demanded the design be subject to an environmental impact report that would include alternative designs. Their complaint is that the project's proposed flyover, a new elevated lane that would extend from Sir Francis Drake Boulevard next to southbound 101 to Wornum Drive, is too much of an "L.A. freeway" solution.
At last week's meeting, Corte Madera's gripe was that TAM's board president Alice Fredericks, a Tiburon town councilwoman, had already been assigned as the special committee's chair. Town representatives have criticized TAM's leadership for pushing the $143 million project forward without making sure every town supports it.
Corte Madera's representatives complained and asked to have a committee vote. Fredericks was elected to chair the committee on a 5-2 vote, with Corte Madera's representatives, Mayor Diane Furst and Councilwoman Carla Condon, casting the dissenting votes. Larkspur's two representatives, Mayor Dan Hillmer and Councilman Brad Marsh, joined the majority.
This vote was less about Fredericks than it was about TAM's push to get this project built, even though Corte Madera long had reservations the project has been driven by the availability of funding, not design.
The TAM committee hopes to solve those problems.
Condon says she's hoping the committee provides "the opportunity to get a fresh perspective."
With five of the committee's members being on the TAM board a different, more collaborative approach will be vital to a successful resolution. Obviously, there's a pressing need for officials on both sides of this debate to listen, and for all sides to feel that they are being heard.
That is what's been missing and why this project has hit a political dead-end.
Disturbing flaws in accident statistics TAM presented to make a case for the project did little to help build trust.
"This issue goes to the heart of the trust issue people are dancing around. Everybody needs to hear that loud and clear," Hillmer said at the summit. He's absolutely right.
The committee's approach will determine the effectiveness of its deliberations. This project has been hamstrung by a lack of trust and strong leadership, making sure that all parties were heard and onboard as it moved forward.
Now, a committee has been formed to address issues that should have been resolved years ago. Fredericks, who gave up her vote as a committee member in an effort to build more trust in the panel's efforts, is optimistic. We hope she's right.


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Waiting for the show to start
Foster the People concert at Aloha Tower Waterfront!! Awesome night :)
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Sponsored by: Desert Diamond Casino
Sep 9, 2013 1:44 AM by Erika Flores
SIERRA VISTA-Local religious leaders are weighing in on the debate in Syria.
Bishops of the Arizona Catholic Conference sent Arizona lawmakers a letter expressing their concern over potential military action in Syria.
Arizona bishops urged them not to resort to military intervention but instead work to end the violence through negotiations.
Bishop Kicanas said Arizona bishops are all in agreement that solving violence with violence just isn't the answer.
Instead, he said it is the United Nation's responsibility to find ways other than military intervention to solve the conflict in Syria.
As Bishop Kicanas preached to parishioners at St. Andrews the Apostle Catholic Church Sunday night, he passionately expressed his view on the conflict in Syria.
Arizona bishops sent a letter to Congress asking them not to support military intervention.
"It's already a tragedy, and to exercise military intervention at this point could only unleash further violence which will not be helpful in realizing what needs to be realized and that is a negotiated solution to this situation," said Bishop Kicanas.
Parishioners applauded as Bishop Kicanas called for a peaceful solution.
"Hopefully we can come together at the table and solve the problem without going to war," said parishioner Chuck Haith.
Members of Congress have been speaking out about the possibility of military intervention.
"I think the access between Syria and Iran, the capacity for chemical weapons and ultimately nuclear weapons with Iran and the security of our allies, Jordan and Israel, which ultimately involves our national security, is the reason we should act," said Representative Peter King.
This is the letter Arizona bishops sent to Congress:
September 6, 2013
Dear Senator/Representative:
As Catholic bishops we are praying for you as you take up the debate regarding the use of military force in Syria. We wish to offer our perspective as pastors of our Dioceses and your constituents.
The use of chemical weapons by any nation is morally reprehensible. The use in Syria has led to many deaths and intense suffering.
With you we mourn for the lives lost in so tragic a way and grieve with the families of the deceased. One hundred thousand Syrians in this civil war have lost their lives. Two million have fled the country as refugees, and more than 4 million within Syria have been driven from their homes by the violence. This tragedy cannot continue. We ought not to fuel violence but seek a negotiated resolution. We ought to learn from the Iraq tragedy that rushing to conclusions without clear evidence can have disastrous consequences.
We have heard the urgent calls of Pope Francis, and our suffering brother bishops of the venerable and ancient Christian communities of the Middle East. They have begged the family of nations not to resort to military intervention in Syria. We join our voice to theirs. We believe a military attack will be counterproductive, could exacerbate the situation, and could have negative unforeseen consequences.
We call on you as members of our Congressional delegation to urge the President to seek a negotiated political settlement. We believe that more lives and livelihoods will be destroyed by military intervention. On this question Pope Francis has been clear: "How much suffering, how much devastation, how much pain has the use of arms carried in its wake in that martyred country, especially among civilians and the unarmed!"
The longstanding position of our Conference of Bishops is that the Syrian people urgently need a political solution. We ask you to work with the President and Congress to engage other governments to obtain a ceasefire in Syria that protects the rights of all its citizens, including Christians and other minorities.
Please be assured of our prayers
Sincerely yours,
Most Rev. Gerald Dino
Bishop of Holy Protection
of Mary Byzantine Catholic
Eparchy of Phoenix
Most Rev. Gerald F. Kicanas
Bishop of Holy Protection Bishop of Tucson
Most Rev. Eduardo A. Nevares
Auxiliary Bishop of Phoenix
Most Rev. Thomas J. Olmsted
Bishop of Phoenix
Most Rev. James S. Wall
Bishop of Gallup
6 hours ago


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