text:
(A neuron's presynaptic partners are adding neurotransmitters to the synaptic clefts either in pulses which correlate with presynaptic action potentials or continuously in a graded response to presynaptic activity.)
Models | Description |
3D model of the olfactory bulb (Migliore et al. 2014) | |
This entry contains a link to a full HD version of movie 1 and the NEURON code of the paper: "Distributed organization of a brain microcircuit analysed by three-dimensional modeling: the olfactory bulb" by M Migliore, F Cavarretta, ML Hines, and GM Shepherd. | |
A model of the femur-tibia control system in stick insects (Stein et al. 2008) | |
We studied the femur-tibia joint control system of the insect leg, and its switch between resistance reflex in posture control and "active reaction" in walking. The "active reaction" is basically a reversal of the resistance reflex. Both responses are elicited by the same sensory input and the same neuronal network (the femur-tibia network). The femur-tibia network was modeled by fitting the responses of model neurons to those obtained in animals. Each implemented neuron has a physiological counterpart. The strengths of 16 interneuronal pathways that integrate sensory input were then assigned three different values and varied independently, generating a database of more than 43 million network variants. The uploaded version contains the model that best represented the resistance reflex. Please see the README for more help. We demonstrate that the combinatorial code of interneuronal pathways determines motor output. A switch between different behaviors such as standing to walking can thus be achieved by altering the strengths of selected sensory integration pathways. | |
A simplified cerebellar Purkinje neuron (the PPR model) (Brown et al. 2011) | |
These models were implemented in NEURON by Sherry-Ann Brown in the laboratory of Leslie M. Loew. The files reproduce Figures 2c-f from Brown et al, 2011 "Virtual NEURON: a Strategy For Merged Biochemical and Electrophysiological Modeling". | |
A two-stage model of dendritic integration in CA1 pyramidal neurons (Katz et al. 2009) | |
"... In a two-stage integration model, inputs contribute directly to dendritic spikes, and outputs from multiple branches sum in the axon. ... We used serial-section electron microscopy to reconstruct individual apical oblique dendritic branches of CA1 pyramidal neurons and observe a synapse distribution consistent with the two-stage integration model. Computational modeling suggests that the observed synapse distribution enhances the contribution of each dendritic branch to neuronal output." | |
Activity dependent changes in dendritic spine density and spine structure (Crook et al. 2007) | |
"... In this work, we extend previous modeling studies [27] by combining a model for activity-dependent spine density with one for calcium-mediated spine stem restructuring. ... Additional equations characterize the change in spine density along the dendrite, the current balance equation for an individual spine head, the change in calcium concentration in the spine head, and the dynamics of spine stem resistance. We use computational studies to investigate the changes in spine density and structure for differing synaptic inputs and demonstrate the effects of these changes on the input-output properties of the dendritic branch. ... " | |
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013) | |
The role of amyloid beta (Aß) in brain function and in the pathogenesis of Alzheimer's disease remains elusive. Recent publications reported that an increase in Aß concentration perturbs presynaptic release in hippocampal neurons, in particular by increasing release probability of CA3-CA1 synapses. The model predics how this alteration can affect synaptic plasticity and signal integration. The results suggest that the perturbation of release probability induced by increased Aß can significantly alter the spike probability of CA1 pyramidal neurons and thus contribute to abnormal hippocampal function during Alzheimer's disease. | |
Balance of excitation and inhibition (Carvalho and Buonomano 2009) | |
" ... Here, theoretical analyses reveal that excitatory synaptic strength controls the threshold of the neuronal input-output function, while inhibitory plasticity alters the threshold and gain. Experimentally, changes in the balance of excitation and inhibition in CA1 pyramidal neurons also altered their input-output function as predicted by the model. These results support the existence of two functional modes of plasticity that can be used to optimize information processing: threshold and gain plasticity." | |
CA1 pyramidal neuron synaptic integration (Jarsky et al. 2005) | |
"The perforant-path projection to the hippocampus forms synapses in the apical tuft of CA1 pyramidal neurons. We used computer modeling to examine the function of these distal synaptic inputs, which led to three predictions that we confirmed in experiments using rat hippocampal slices. ... This 'gating' of dendritic spike propagation may be an important activation mode of CA1 pyramidal neurons, and its modulation by neurotransmitters or long-term, activity-dependent plasticity may be an important feature of dendritic integration during mnemonic processing in the hippocampus." | |
CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008) | |
The model shows how different input patterns (irregular & asynchronous, irregular & synchronous, regular & asynchronous, regular & synchronous) affect the neuron's output rate when 1000 synapses are distributed in the proximal apical dendritic tree of a hippocampus CA1 pyramidal neuron. | |
CA1 pyramidal neuron: Ih current (Migliore et al. 2012) | |
NEURON files from the paper: Migliore M, Migliore R (2012) Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations. PLoS ONE 7(5): e36867. doi:10.1371/journal.pone.0036867. Experimental findings on the effects of Ih current modulation, which is particularly involved in epilepsy, appear to be inconsistent. In the paper, using a realistic model we show how and why a shunting current, such as that carried by TASK-like channels, dependent on the Ih peak conductance is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions. | |
CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010) | |
The model demonstrates that CA1 pyramidal neurons support rebound spikes mediated by hyperpolarization-activated inward current (Ih), and normally masked by A-type potassium channels (KA). Partial KA reduction confined to one or few branches of the apical tuft may be sufficient to elicit a local spike following a train of synaptic inhibition. These data suggest that the plastic regulation of KA can provide a dynamic switch to unmask post-inhibitory spiking in CA1 pyramidal neurons, further increasing the signal processing power of the CA1 synaptic microcircuitry. | |
CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011) | |
NEURON files from the paper: A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. by M. Migliore, I. De Blasi, D. Tegolo, R. Migliore, Neural Networks,(2011), doi:10.1016/j.neunet.2011.01.001. Starting from the experimentally supported assumption on hippocampal neurons we explore an experimentally testable prediction at the single neuron level. The model shows how and to what extent a pathological hypofunction of a contextdependent distal input on a CA1 neuron can generate hallucinations by altering the normal recall of objects on which the neuron has been previously tuned. The results suggest that a change in the context during the recall phase may cause an occasional but very significant change in the set of active dendrites used for features recognition, leading to a distorted perception of objects. | |
CA1 Pyramidal Neuron: slow Na+ inactivation (Migliore 1996) | |
Model files from the paper: M. Migliore, Modeling the attenuation and failure of action potentials in the dendrites of hippocampal neurons, Biophys. J. 71:2394-403 (1996). Please see the below readme file for installation and use instructions. Contact firstname.lastname@example.com if you have any questions about the implementation of the model. | |
CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008) | |
NEURON files from the paper: Single neuron binding properties and the magical number 7, by M. Migliore, G. Novara, D. Tegolo, Hippocampus, in press (2008). In an extensive series of simulations with realistic morphologies and active properties, we demonstrate how n radial (oblique) dendrites of these neurons may be used to bind n inputs to generate an output signal. The results suggest a possible neural code as the most effective n-ple of dendrites that can be used for short-term memory recollection of persons, objects, or places. Our analysis predicts a straightforward physiological explanation for the observed puzzling limit of about 7 short-term memory items that can be stored by humans. | |
CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014) | |
The paper discusses the effects induced by an electric field at power lines frequency. | |
CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011) | |
NEURON mod files from the paper: Shah et al., 2011. In this study, using a combination of electrophysiology and computational modelling, we show that these channels selectively influence peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in CA1 pyramidal cells. This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy. | |
CA3 Pyramidal Neuron (Migliore et al 1995) | |
Model files from the paper: M. Migliore, E. Cook, D.B. Jaffe, D.A. Turner and D. Johnston, Computer simulations of morphologically reconstructed CA3 hippocampal neurons, J. Neurophysiol. 73, 1157-1168 (1995). Demonstrates how the same cell could be bursting or non bursting according to the Ca-independent conductance densities. Includes calculation of intracellular Calcium. Instructions are provided in the below README file. Contact email@example.com if you have any questions about the implementation of the model. | |
CA3 pyramidal neuron (Safiulina et al. 2010) | |
In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. To compare the relative strength of CA3 pyramidal cell output in relation to their MF glutamatergic or GABAergic inputs in postnatal development, a realistic model was constructed taking into account the different biophysical properties of these synapses. | |
Ca3 pyramidal neuron: membrane response near rest (Hemond et al. 2009) | |
In this paper, the model was used to show how the temporal summation of excitatory inputs in CA3 pyramidal neurons was affected by the presence of Ih in the dendrites in a frequency- and distance-dependent fashion. | |
Calcium spikes in basal dendrites (Kampa and Stuart 2006) | |
This model was published in Kampa & Stuart (2006) J Neurosci 26(28):7424-32. The simulation creates two plots showing voltage and calcium changes in basal dendrites of layer 5 pyramidal neurons during action potential backpropagation. created by B. Kampa (2006) | |
Cerebellar Nucleus Neuron (Steuber, Schultheiss, Silver, De Schutter & Jaeger, 2010) | |
This is the GENESIS 2.3 implementation of a multi-compartmental deep cerebellar nucleus (DCN) neuron model with a full dendritic morphology and appropriate active conductances. We generated a good match of our simulations with DCN current clamp data we recorded in acute slices, including the heterogeneity in the rebound responses. We then examined how inhibitory and excitatory synaptic input interacted with these intrinsic conductances to control DCN firing. We found that the output spiking of the model reflected the ongoing balance of excitatory and inhibitory input rates and that changing the level of inhibition performed an additive operation. Rebound firing following strong Purkinje cell input bursts was also possible, but only if the chloride reversal potential was more negative than -70 mV to allow de-inactivation of rebound currents. Fast rebound bursts due to T-type calcium current and slow rebounds due to persistent sodium current could be differentially regulated by synaptic input, and the pattern of these rebounds was further influenced by HCN current. Our findings suggest that active properties of DCN neurons could play a crucial role for signal processing in the cerebellum. | |
Cerebellar purkinje cell (De Schutter and Bower 1994) | |
Tutorial simulation of a cerebellar Purkinje cell. This tutorial is based upon a GENESIS simulation of a cerebellar Purkinje cell, modeled and fine-tuned by Erik de Schutter. The tutorial assumes that you have a basic knowledge of the Purkinje cell and its synaptic inputs. It gives visual insight in how different properties as concentrations and channel conductances vary and interact within a real Purkinje cell. | |
CN pyramidal fusiform cell (Kanold, Manis 2001) | |
Pyramidal cells in the dorsal cochlear nucleus (DCN) show three characteristic discharge patterns in response tones: pauser, buildup, and regular firing. Experimental evidence suggests that a rapidly inactivating K+ current (I(KIF)) plays a critical role in generating these discharge patterns. To explore the role of I(KIF), we used a computational model based on the biophysical data. The model replicated the dependence of the discharge pattern on the magnitude and duration of hyperpolarizing prepulses, and I(KIF) was necessary to convey this dependence. Experimentally, half-inactivation voltage and kinetics of I(KIF) show wide variability. Varying these parameters in the model ... suggests that pyramidal cells can adjust their sensitivity to different temporal patterns of inhibition and excitation by modulating the kinetics of I(KIF). Overall, I(KIF) is a critical conductance controlling the excitability of DCN pyramidal cells. (See readme.txt and paper for details). Any questions regarding these implementations should be directed to: email@example.com 2 April 2004 Paul B Manis, Ph.D. | |
Coincidence detection in avian brainstem (Simon et al 1999) | |
A detailed biophysical model of coincidence detector neurons in the nucleus laminaris (auditory brainstem) which are purported to detect interaural time differences (ITDs) from Simon et al 1999. | |
Comparison of full and reduced globus pallidus models (Hendrickson 2010) | |
In this paper, we studied what features of realistic full model activity patterns can and cannot be preserved by morphologically reduced models. To this end, we reduced the morphological complexity of a full globus pallidus neuron model possessing active dendrites and compared its spontaneous and driven responses to those of the reduced models. | |
Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008) | |
In this paper, the model was used to show how neuroactive drugs targeting different neuronal mechanisms affect the signal integration in CA1 pyramidal neuron. Ferrante M, Blackwell KT, Migliore M, Ascoli GA (2008) | |
Contrast invariance by LGN synaptic depression (Banitt et al. 2007) | |
"Simple cells in layer 4 of the primary visual cortex of the cat show contrast-invariant orientation tuning, in which the amplitude of the peak response is proportional to the stimulus contrast but the width of the tuning curve hardly changes with contrast. This study uses a detailed model of spiny stellate cells (SSCs) from cat area 17 to explain this property. The model integrates our experimental data, including morphological and intrinsic membrane properties and the number and spatial distribution of four major synaptic input sources of the SSC: the dorsal lateral geniculate nucleus (dLGN) and three cortical sources. ... The model response is in close agreement with experimental results, in terms of both output spikes and membrane voltage (amplitude and fluctuations), with reasonable exceptions given that recurrent connections were not incorporated." | |
Cortical network model of posttraumatic epileptogenesis (Bush et al 1999) | |
This simulation from Bush, Prince, and Miller 1999 shows the epileptiform response (Fig. 6C) to a brief single stimulation in a 500 cell network of multicompartment models, some of which have active dendrites. The results which I obtained under Redhat Linux is shown in result.gif. Original 1997 code from Paul Bush modified slightly by Bill Lytton to make it work with current version of NEURON (5.7.139). Thanks to Paul Bush and Ken Miller for making the code available. | |
Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010) | |
Compartmental model of a layer 2/3 pyramidal cell in the rat somatosensory cortex, exploring NMDA-dependent sensitivity to the temporal sequence of synaptic activation. | |
Dendritic processing of excitatory synaptic input in GnRH neurons (Roberts et al. 2006) | |
"... we used electrophysiological recordings and neuronal reconstructions to generate computer models of (Gonadotopin-Releasing Hormone) GnRH neurons to examine the effects of synaptic inputs at varying distances from the soma along dendrites. ... analysis of reduced morphology models indicated that this population of cells is unlikely to exhibit low-frequency tonic spiking in the absence of synaptic input. ... applying realistic patterns of synaptic input to modeled GnRH neurons indicates that synapses located more than about 30% of the average dendrite length from the soma cannot drive firing at frequencies consistent with neuropeptide release. Thus, processing of synaptic input to dendrites of GnRH neurons is probably more complex than simple summation." | |
Dentate gyrus granule cell: subthreshold signal processing (Schmidt-Hieber et al. 2007) | |
Detailed compartmental cable models of 8 hippocampal granule cells of adult mice were obtained from dual patch-clamp whole-cell recordings and subsequent 3D reconstructions. This code allows to reproduce figures 6-8 from the paper. | |
Dentate gyrus network model (Santhakumar et al 2005) | |
Mossy cell loss and mossy fiber sprouting are two characteristic consequences of repeated seizures and head trauma. However, their precise contributions to the hyperexcitable state are not well understood. Because it is difficult, and frequently impossible, to independently examine using experimental techniques whether it is the loss of mossy cells or the sprouting of mossy fibers that leads to dentate hyperexcitability, we built a biophysically realistic and anatomically representative computational model of the dentate gyrus to examine this question. The 527-cell model, containing granule, mossy, basket, and hilar cells with axonal projections to the perforant-path termination zone, showed that even weak mossy fiber sprouting (10-15% of the strong sprouting observed in the pilocarpine model of epilepsy) resulted in the spread of seizure-like activity to the adjacent model hippocampal laminae after focal stimulation of the perforant path. See reference for more and details. | |
Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009) | |
"Inward rectifying potassium (KIR) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in ~40% of the neurons but not in the rest, which may lead to differences in input processing by these two groups. Using a 189-compartment computational model of the MS neuron, we investigate the influence of this property using injected current as well as spatiotemporally distributed synaptic inputs. Our study demonstrates that KIR current inactivation facilitates depolarization, firing frequency and firing onset in these neurons. ..." | |
Effects of synaptic location and timing on synaptic integration (Rall 1964) | |
Reproduces figures 5 - 8 from Rall, W. Theoretical significance of dendritic trees for neuronal input-output relations. In: Neural Theory and Modeling, ed. Reiss, R.F., Palo Alto: Stanford University Press (1964). | |
Electrically-coupled Retzius neurons (Vazquez et al. 2009) | |
"Dendritic electrical coupling increases the number of effective synaptic inputs onto neurons by allowing the direct spread of synaptic potentials from one neuron to another. Here we studied the summation of excitatory postsynaptic potentials (EPSPs) produced locally and arriving from the coupled neuron (transjunctional) in pairs of electrically-coupled Retzius neurons of the leech. We combined paired recordings of EPSPs, the production of artificial EPSPs (APSPs) in neuron pairs with different coupling coefficients and simulations of EPSPs produced in the coupled dendrites. ..." | |
Excitatory synaptic interactions in pyramidal neuron dendrites (Behabadi et al. 2012) | |
" ... We hypothesized that if two excitatory pathways bias their synaptic projections towards proximal vs. distal ends of the basal branches, the very different local spike thresholds and attenuation factors for inputs near and far from the soma might provide the basis for a classical-contextual functional asymmetry. Supporting this possibility, we found both in compartmental models and electrophysiological recordings in brain slices that the responses of basal dendrites to spatially separated inputs are indeed strongly asymmetric. ..." | |
Functional structure of mitral cell dendritic tuft (Djurisic et al. 2008) | |
The computational modeling component of Djurisic et al. 2008 addressed two primary questions: whether amplification by active currents is necessary to explain the relatively mild attenuation suffered by tuft EPSPs spreading along the primary dendrite to the soma; what accounts for the relatively uniform peak EPSP amplitude throughout the tuft. These simulations show that passive spread from tuft to soma is sufficient to yield the low attenuation of tuft EPSPs, and that random distribution of a biologically plausible number of excitatory synapses throughout the tuft can produce the experimentally observed uniformity of depolarization. | |
Gamma oscillations in hippocampal interneuron networks (Bartos et al 2002) | |
To examine whether an interneuron network with fast inhibitory synapses can act as a gamma frequency oscillator, we developed an interneuron network model based on experimentally determined properties. In comparison to previous interneuron network models, our model was able to generate oscillatory activity with higher coherence over a broad range of frequencies (20-110 Hz). In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling. | |
Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010) | |
A set of 9 multi-compartmental rat GP neuron models (585 compartments) differing only in their expression of dendritic fast sodium channels were compared in their synaptic integration properties. Dendritic fast sodium channels were found to increase the importance of distal synapses (both excitatory AND inhibitory), increase spike timing variability with in vivo-like synaptic input, and make the model neurons highly sensitive to clustered synchronous excitation. | |
GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011) | |
Phase response analysis of a GP neuron model showing type I PRCs for somatic inputs and type II PRCs for dendritic excitation. Analysis of intrinsic currents underlying type II dendritic PRCs. | |
Granule Cells of the Olfactory Bulb (Simoes_De_Souza et al. 2014) | |
Electrical responses of three classes of granule cells of the olfactory bulb to synaptic activation in different dendritic locations. The constructed models were based on morphological detailed compartmental reconstructions of three granule cell classes of the olfactory bulb with active dendrites described by Bhalla and Bower (J. Neurophysiol. 69: 1948-1965, 1993) and dendritic spine distributions described by Woolf et al. (J. Neurosci. 11: 1837-1854, 1991). The computational studies with the model neurons showed that different quantities of spines have to be activated in each dendritic region to induce an action potential, which always was originated in the active terminal dendrites, independently of the location of the stimuli and the morphology of the dendritic tree. | |
Ih levels roles in bursting and regular-spiking subiculum pyramidal neurons (van Welie et al 2006) | |
Pyramidal neurons in the subiculum typically display either bursting or regular-spiking behavior. ... Here we report that bursting neurons posses a hyperpolarization-activated cation current (Ih) that is two-fold larger (conductance: 5.3 ± 0.5 nS) than in regularspiking neurons (2.2 ± 0.6 nS), while Ih exhibits similar voltage-dependent and kinetic properties in both classes of neurons. Bursting and regular-spiking neurons display similar morphology. The difference in Ih between the two classes is not responsible for the distinct firing patterns, since neither pharmacological blockade of Ih nor enhancement of Ih using a dynamic clamp affects the qualitative firing patterns. Instead, the difference in Ih between bursting and regular-spiking neurons determines the temporal integration of evoked synaptic input from the CA1 area. In response to 50 Hz stimulation, bursting neurons, with a large Ih, show ~50% less temporal summation than regular-spiking neurons. ... A computer simulation model of a subicular neuron with the properties of either a bursting or a regular-spiking neuron confirmed the pivotal role of Ih in temporal integration of synaptic input. These data suggest that in the subicular network, bursting neurons are better suited to discriminate the content of high frequency input, such as that occurring during gamma oscillations, compared to regular-spiking neurons. See paper for more and details. | |
Interacting synaptic conductances during, distorting, voltage clamp (Poleg-Polsky and Diamond 2011) | |
This simulation examines the accuracy of the voltage clamp technique in detecting the excitatory and the inhibitory components of the synaptic drive. | |
Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) | |
" ... Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca21- dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals." | |
Large scale model of the olfactory bulb (Yu et al., 2013) | |
The readme file currently contains links to the results for all the 72 odors investigated in the paper, and the movie showing the network activity during learning of odor k3-3 (an aliphatic ketone). | |
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011) | |
The hippocampus in well known for its role in learning and memory processes. The CA1 region is the output of the hippocampal formation and pyramidal neurons in this region are the elementary units responsible for the processing and transfer of information to the cortex. Using this detailed single neuron model, it is investigated the conditions under which individual CA1 pyramidal neurons process incoming information in a complex (non-linear) as opposed to a passive (linear) manner. This detailed compartmental model of a CA1 pyramidal neuron is based on one described previously (Poirazi, 2003). The model was adapted to five different reconstructed morphologies for this study, and slightly modified to fit the experimental data of (Losonczy, 2006), and to incorporate evidence in pyramidal neurons for the non-saturation of NMDA receptor-mediated conductances by single glutamate pulses. We first replicate the main findings of (Losonczy, 2006), including the very brief window for nonlinear integration using single-pulse stimuli. We then show that double-pulse stimuli increase a CA1 pyramidal neuron's tolerance for input asynchrony by at last an order of magnitude. Therefore, it is shown using this model, that the time window for nonlinear integration is extended by more than an order of magnitude when inputs are short bursts as opposed to single spikes. | |
MEC layer II stellate cell: Synaptic mechanisms of grid cells (Schmidt-Hieber & Hausser 2013) | |
This study investigates the cellular mechanisms of grid field generation in Medial Entorhinal Cortex (MEC) layer II stellate cells. | |
Mechanisms underlying subunit independence in pyramidal neuron dendrites (Behabadi and Mel 2014) | |
"...Using a detailed compartmental model of a layer 5 pyramidal neuron, and an improved method for quantifying subunit independence that incorporates a more accurate model of dendritic integration, we first established that the output of each dendrite can be almost perfectly predicted by the intensity and spatial configuration of its own synaptic inputs, and is nearly invariant to the rate of bAP-mediated 'cross-talk' from other dendrites over a 100-fold range..." | |
Membrane potential changes in dendritic spines during APs and synaptic input (Palmer & Stuart 2009) | |
" ... Finally, we used simulations of our experimental observations in morphologically realistic models to estimate spine neck resistance. These simulations indicated that spine neck resistance ranges up to ~500 M Ohm. Spine neck resistances of this magnitude reduce somatic EPSPs by ~15%, indicating that the spine neck is unlikely to act as a physical device to significantly modify synaptic strength." | |
Motoneuron model of self-sustained firing after spinal cord injury (Kurian et al. 2011) | |
" ... During the acute-stage of spinal cord injury (SCI), the endogenous ability to generate plateaus is lost; however, during the chronic-stage of SCI, plateau potentials reappear with prolonged self-sustained firing that has been implicated in the development of spasticity. In this work, we extend previous modeling studies to systematically investigate the mechanisms underlying the generation of plateau potentials in motoneurons, including the influences of specific ionic currents, the morphological characteristics of the soma and dendrite, and the interactions between persistent inward currents and synaptic input. ..." | |
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010) | |
Cannabinoid withdrawal produces a hypofunction of dopaminergic neurons targeting medium spiny neurons (MSN) of the forebrain. Administration of a CB1 receptor antagonist to control rats provoked structural abnormalities, reminiscent of those observed in withdrawal conditions and support the regulatory role of cannabinoids in neurogenesis, axonal growth and synaptogenesis. Experimental observations were incorporated into a realistic computational model which predicts a strong reduction in the excitability of morphologically-altered MSN, yielding a significant reduction in action potential output. These paper provided direct morphological evidence for functional abnormalities associated with cannabinoid dependence at the level of dopaminergic neurons and their post synaptic counterpart, supporting a hypodopaminergic state as a distinctive feature of the "addicted brain". | |
Nonlinear dendritic processing in barrel cortex spiny stellate neurons (Lavzin et al. 2012) | |
This is a multi-compartmental simulation of a spiny stellate neuron which is stimulated by a thalamocortical (TC) and cortico-cortical (CC) inputs. No other cells are explicitly modeled; the presynaptic network activation is represented by the number of active synapses. Preferred and non –preferred thalamic directions thus correspond to larder/smaller number of TC synapses. This simulation revealed that randomly activated synapses can cooperatively trigger global NMDA spikes, which involve participation of most of the dendritic tree. Surprisingly, we found that although the voltage profile of the cell was uniform, the calcium influx was restricted to 'hot spots' which correspond to synaptic clusters or large conductance synapses | |
Olfactory Mitral cell: AP initiation modes (Chen et al 2002) | |
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite. | |
Pyramidal neurons switch from integrators to resonators (Prescott et al. 2008) | |
During wakefulness, pyramidal neurons in the intact brain are bombarded by synaptic input that causes tonic depolarization, increased membrane conductance (i.e. shunting), and noisy fluctuations in membrane potential; by comparison, pyramidal neurons in acute slices typically experience little background input. Such differences in operating conditions can compromise extrapolation of in vitro data to explain neuronal operation in vivo. ... in slice experiments, we show that CA1 hippocampal pyramidal cells switch from integrators to resonators, i.e. from class 1 to class 2 excitability. The switch is explained by increased outward current contributed by the M-type potassium current IM ... Thus, even so-called "intrinsic" properties may differ qualitatively between in vitro and in vivo conditions. | |
Role of active dendrites in rhythmically-firing neurons (Goldberg et al 2006) | |
"The responsiveness of rhythmically-firing neurons to synaptic inputs is characterized by their phase response curve (PRC), which relates how weak somatic perturbations affect the timing of the next action potential. The shape of the somatic PRC is an important determinant of collective network dynamics. Here we study theoretically and experimentally the impact of distally-located synapses and dendritic nonlinearities on the synchronization properties of rhythmically firing neurons. Combining the theories of quasi-active cables and phase-coupled oscillators we derive an approximation for the dendritic responsiveness, captured by the neuron's dendritic PRC (dPRC). This closed-form expression indicates that the dPRCs are linearly-filtered versions of the somatic PRC, and that the filter characteristics are determined by the passive and active properties of the dendrite. ... collective dynamics can be qualitatively different depending on the location of the synapse, the neuronal firing rates and the dendritic nonlinearities." See paper for more and details. | |
Spatial summation of excitatory and inhibitory inputs in pyramidal neurons (Hao et al. 2010) | |
"... Based on realistic modeling and experiments in rat hippocampal slices, we derived a simple arithmetic rule for spatial summation of concurrent excitatory glutamatergic inputs (E) and inhibitory GABAergic inputs (I). The somatic response can be well approximated as the sum of the excitatory postsynaptic potential (EPSP), the inhibitory postsynaptic potential (IPSP), and a nonlinear term proportional to their product (k*EPSP*IPSP), where the coefficient k reflects the strength of shunting effect. ..." | |
Spiking GridPlaceMap model (Pilly & Grossberg, PLoS One, 2013) | |
Development of spiking grid cells and place cells in the entorhinal-hippocampal system to represent positions in large spaces | |
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014) | |
"We use a computational model of a hippocampal CA1 pyramidal cell to demonstrate that spine head calcium provides an instantaneous readout at each synapse of the postsynaptic weighted sum of all presynaptic activity impinging on the cell. The form of the readout is equivalent to the functions of weighted, summed inputs used in neural network learning rules. Within a dendritic layer, peak spine head calcium levels are either a linear or sigmoidal function of the number of coactive synapses, with nonlinearity depending on the ability of voltage spread in the dendrites to reach calcium spike threshold. ..." | |
STDP and NMDAR Subunits (Gerkin et al. 2007) | |
The paper argues for competing roles of NR2A- and NR2B-containing NMDARs in spike-timing-dependent plasticity. This simple dynamical model recapitulates the results of STDP experiments involving selective blockers of NR2A- and NR2B-containing NMDARs, for which the stimuli are pre- and postsynaptic spikes in varying combinations. Experiments were done using paired recordings from glutamatergic neurons in rat hippocampal cultures. This model focuses on the dynamics of the putative potentiation and depression modules themselves, and their interaction For detailed dynamics involving NMDARs and Ca2+ transients, see Rubin et al., J. Neurophys., 2005. | |
Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009) | |
Simulations used in the paper. Voltage responses to current injections in different tuft locations; NMDA and calcium spike generation. Summation of multiple input distribution. | |
Synaptic integration of an identified nonspiking interneuron in crayfish (Takashima et al 2006) | |
This GENESIS simulation shows how a single or compound excitatory synaptic potential evoked by mechanosensory stimulation spreads over the dendrites of the LDS interneuron that is one of the identified nonspiking interneurons in the central nervous system of crayfish Procambarus clarkii. The model is based on physiological experiments carried out by Akira Takashima using single-electrode voltage clamp techniques and also 3-D morphometry of the interneuron carried out by Ryou Hikosaka using confocal laser scanning microscopic techniques. The physiological and morphological studies were coordinated by Masakazu Takahata. | |
Thalamic neuron, zebra finch DLM: Integration of pallidal and cortical inputs (Goldberg et al. 2012) | |
This is a single-compartment model of a zebra finch thalamic relay neuron from nucleus DLM. It is used to explore the interaction between cortex-like glutamatergic input and pallidum-like GABAergic input as they control the spiking output of these neurons. | |
Thalamocortical augmenting response (Bazhenov et al 1998) | |
In the cortical model, augmenting responses were more powerful in the "input" layer compared with those in the "output" layer. Cortical stimulation of the network model produced augmenting responses in cortical neurons in distant cortical areas through corticothalamocortical loops and low-threshold intrathalamic augmentation. ... The predictions of the model were compared with in vivo recordings from neurons in cortical area 4 and thalamic ventrolateral nucleus of anesthetized cats. The known intrinsic properties of thalamic cells and thalamocortical interconnections can account for the basic properties of cortical augmenting responses. See reference for details. NEURON implementation note: cortical SU cells are getting slightly too little stimulation - reason unknown. | |
Using Strahler`s analysis to reduce realistic models (Marasco et al, 2013) | |
Building on our previous work (Marasco et al., (2012)), we present a general reduction method based on Strahler's analysis of neuron morphologies. We show that, without any fitting or tuning procedures, it is possible to map any morphologically and biophysically accurate neuron model into an equivalent reduced version. Using this method for Purkinje cells, we demonstrate how run times can be reduced up to 200-fold, while accurately taking into account the effects of arbitrarily located and activated synaptic inputs. | |
Voltage attenuation in CA1 pyramidal neuron dendrites (Golding et al 2005) | |
Voltage attenuation in the apical dendritic field of CA1 pyramidal neurons is particularly strong for epsps spreading toward the soma. High cytoplasmic resistivity and high membrane (leak) conductance appear to be the major determinants of voltage attenuation over most of the apical field, but H current may be responsible for as much as half of the attenuation of distal apical epsps. |
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text:
Antichrist (2009), directed by Lars von Trier
If the aim of science and philosophy is to find order in the Universe, and the aim of religion and politics to impose order on the Universe, then it is not wrong to say that the dissolution of order is, above all else, what man fears most.
I knew Antichrist would be a dark film, but as someone who has spent a considerable time looking at the darker side of human nature, it's difficult for me to judge just how disturbing this film might be to someone not exposed to such content.
But before I continue, let me quote the product description from Amazon.com:
Lars von Trier shook up the film world when he premiered Antichrist at the 2009 Cannes Film Festival. In this graphic psychodrama, a grief-stricken man and woman—a searing Willem Dafoe and Cannes best actress Charlotte Gainsbourg—retreat to a cabin deep in the woods after the accidental death of their infant son, only to find terror and violence at the hands of nature and, ultimately, each other. But this most confrontational work yet from one of contemporary cinema's most controversial artists is no mere provocation. It is a visually sublime, emotionally ravaging journey to the darkest corners of the possessed human mind; a disturbing battle of the sexes that pits rational psychology against age-old superstition; and a profoundly effective horror film.
To me, Antichrist was certainly dark, but not nearly as psychologically disturbing as I expected it to be. I think I was more captivated by the emotional intimacy of this film than I was of the content or violence. It is definitely original, and I can think of no other film quite like it.
I wasn't entirely happy with the cinematography. Some of it was quite awkward and ineffective, and I just didn't like the editing. While the photography (especially in the woods) was very beautiful, I did find the brief intervals of CGI dream sequences to be unnecessary and ineffective. I just didn't see how any of it added to the film. It certainly could have stood alone without them.
As far as the themes of Antichrist, I'm not sure I want to get into that at this point, simply because it would take too long (as there are so many, most of which are metaphorical), and also because it would be irrelevant if you haven't seen the film. (If you have seen the film, we can discuss if you'd like.)
But suffice to say that I saw it as less about evil and more about a descent into madness. The bizarre behavior and violence reminded me more of Roman Polanski's Repulsion than it did of any other film in which a person takes pleasure in doing evil for evil's sake. Indeed, the evil of Antichrist is more about the disorder of the world -- the loss of what most people come to cherish as normal, acceptable, or predictible.
I also think the product description above overstates the events when it said they found "terror and violence at the hands of nature," as there didn't seem to be that much natural evil in the movie.
There is a lot of graphic sex and violence, so this is not a film for just anyone. I think this is an important film, and will be a must-see for any serious student of film. But I'm not sure I'm ready to say it is a "masterpiece."
Official Site
Wikipedia Page (lots of good links in the references)
Review from Variety (haven't read yet)
A blog post/essay (haven't read yet)
Tags: Antichrist, Charlotte Gainsbourg, Lars von Trier, Willem Defoe, cinema, female sexuality, film, madness, movie, violence
Yeah, from wikipedia:
The title was the first thing that was written for the film.[8] Antichrist was originally scheduled for production in 2005, but its executive producer Peter Aalbæk Jensen accidentally revealed the film's planned revelation: that Earth was created by Satan and not by God. Trier was furious and decided to delay the shoot so he could rewrite the script.
The idea that the world was created by Satan is an old one that some Christian sects believed.
Sorry Dallas, busy elsewhere. In a word, do you think this is a movie worth watching mate?
I just got through Diving Bell and the Butterfly the other night and that's a hell of a testament to the human "spirit".
Yes, I do think it is worth watching. It does have it's flaws -- namely that the artsy-fartsy stuff doesn't add a lot of genuine value to it, I think. But any student of film needs to see it.
Yes, DBB was just an okay movie, I thought, but you're right -- what a spirit he had.
Yeah. It certainly is.
I thought Von Trier was getting a bit above himself. Although the cinematography is superb in places, it's hardly Dogme 95 which Von Trier was part of.
Not being a kiss-arse, but I agree with your review, Dallas. Very much how it struck me - and no way a masterpiece.
That's okay. I like ass-kissers! : )
Glad you finally got around to seeing it. While not a masterpiece, I still think it will go down in the annals of cinematography as an important film.
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subset: commoncrawl


text:
Graduate Mathematics Courses
MAT 508 Technology-Enhanced Mathematics Instruction I
Technology tools for the math teacher for lesson preparation and presentations. Techniques
for integrating dynamic computer software applications and the graphing calculator
and its applications in teaching. Designing technology-based activities for mathematics
instruction. Graphing calculator required. Prerequisite: MAT 151. 3 credits.
MAT 514 Teaching Mathematics to Accelerated Students and Low Achievers
Characteristics and needs of low achievers and accelerated students in mathematics,
and methods of effectively teaching those two student populations. 3 credits.
MAT 518 Technology-Enhanced Mathematics Instruction II
Techniques for creating new tools and using advanced options in dynamic software,
writing and using calculator programs to enhance mathematics instruction, and designing
inquiry-based activities using technology for mathematics instruction. Graphing calculator
required. Prerequisite : Grade of C or higher in MAT 508. 3 credits.
MAT 525 Probability and Statistics (Certification Program)
Descriptive statistics; introduction to probability theory; probability and sampling
distributions; hypothesis testing and estimation; non-parametric tests. 4 credits.
MAT 526 Probability and Applied Statistics II
Linear regression and correlation, analysis of variance and applications. Prerequisite:
Grade of C or higher in MAT 525 or departmental permission. 3 credits.
MAT 530 Foundation of Geometry
An axiomatic development of Euclidean and non-Euclidean geometries. Prerequisite
: Grade of C or higher in MAT 250. 3 credits.
MAT 541 Topics in Real Analysis
The real numbers as a metric space, limits in metric spaces, integration, topics
in calculus of two and three variables, applications. Prerequisite: Grade of C or
higher in both MAT 151 and MAT 250 and admission to M.S. Program in mathematical education
or departmental permission. 4 credits.
MAT 560 Topology
Metric spaces and fundamental concepts, topological spaces, subspaces and product
spaces, countability properties, separation properties, compactness, and connectedness.
Prerequisite: Grade of C of higher in MAT 250. 3 credits.
MAT 573 Algebraic Structures I (Certification Program)
Matrices and vectors; systems of linear equations; introduction to groups, rings,
fields and vector spaces; linear and affine transformations. Certification only. Prerequisite:
Grade of C or higher in MAT 250. 4 credits.
MAT 574 Algebraic Structures II
Direct products and factor groups; ideals and factor rings; polynomial rings; extension
fields; introduction to Galois theory. Prerequisite: Grade of C or higher in MAT 573
or departmental permission. 3 credits.
MAT 580 Introduction to Research in Mathematics Education
Examines a general overview of social science research, a brief history of mathematics
education research, and the application of experimental, descriptive, qualitative,
and meta-analysis methods in the field of mathematics education. Prerequisites: MAT
525 or equivalent.
MAT 590 Thesis Seminar
Research and writing of the thesis in the area of concentration, under the direction
of a mathematics department faculty member. For specific details, consult the chairperson
or graduate coordinator of the department. Prerequisite : departmental permission.
6 credits.
MAT 595 Seminar in Mathematics Education
Current issues in mathematics education. 3 credits.
MAT 600 Independent Study
Provides qualified students with an opportunity for independent study and careful
discussion from an advanced standpoint of selected topics in mathematics. Prerequisite
: departmental permission. 1-3 credits.


text:
Dog Behavior Library
Cat Behavior Library
Caring For Pets
Pet First Aid Class
Emergency Pet Preparedness
Lost & Found
Feral Cat Tips
Contra Costa County Resources
Starting a Rescue Organization
Forming a Non-Profit Organization
The following is a list of additional Contra Costa County, California based animal welfare agencies that partner with ARF to combine resources and help make a difference in the lives of animals in Contra Costa County. Please contact the listed agencies for adoption opportunities, spay/neuter and specialized services.
Antioch Animal Services www.ci.antioch.ca.us 300 "L" Street, Antioch, CA 94509 925.779.6989
Shelter Hours: Monday, Wednesday, Friday, Saturday - 10 a.m. to 4 p.m. Tuesday, Thursday - 10 a.m. to 8 p.m.
Contra Costa Animal Services www.ccasd.org
Click here for a link to shelter and clinic hours.
Martinez 4800 Imhoff Place, Martinez, CA 94553 925.335.8300 - Main Desk 925.335.8330 - Volunteers
Pinole 651 Pinole Shores Drive, Pinole, CA 94501 510.374.3966 - Main Desk 510.724.1036 - Volunteers
Contra Costa Humane Society www.cchumane.org 609 Gregory Lane, No. 140, Pleasant Hill, CA 94523 925.279.CCHS
Feral Cat Foundation www.feralcatfoundation.org P.O. Box 1173, Alamo, CA 94507 Feral cat trapping and feral cat colony maintenance advise and support given.
Fix Our Ferals www.fixourferals.org Fix Our Ferals offers free spay/neuter clinics for homeless cats in Alameda and Contra Costa counties. They have helped more than 2,000 East Bay residents to sterilize over 9,600 cats since starting in 1998.
Homeless Animals' Lifeline Organization (HALO) www.eccchalo.org P.O. Box 2011, Antioch, CA 94531 925.473.4642
Back To Top
Back To Resources & Links
Back To Home
Follow ARF on: Facebook » Twitter » YouTube » Yelp » | Privacy Policy • Contact ARF
© 2012 Tony La Russa's Animal Rescue Foundation. All rights reserved.


text:
Sponsored By
Become a Sponsor
Spinitron Home Member Logon About Spinitron Charts KDHX's web site
SPINITRON home
Current playlist Program schedule KDHX's web site
BrowseArtists · Disks · Labels
Search the selected month Artists Disks Songs
Prince Buster merch
Disks by Prince Buster logged in KDHX's playlists:
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text:
After extensive field testing in the UK, USA and in the debate with Dr Calvin Smith on Revelation TV, "Has the Church Replaced Israel", I have revised and enhanced my paper 'Seven Biblical Answers to Popular Zionist Assumptions' You can access a text version here. The pdf version contains additional illustrations.
The fundamental question to ask is this: Does the New Testament teach that the coming of Jesus Christ was the fulfilment or postponement of God's promises to Abraham and purposes for the Jewish people?
This study is based on Zion's Christian Soldiers: The Bible Israel and the Church (IVP) and may be downloaded. A more comprehensive Bible study guide can be accessed from www.withgodonourside.com


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Jobs giant: how Matt Barrie built a global empire
Entrepreneur Secrets Matt Barrie's giant outsourcing marketplace, Freelancer.com, racked up $US35 million last year.
The $62 million man who proved his mum wrong
Entrepreneur Secrets In Ruslan Kogan's case, mum doesn't always know best.
Typhoon tycoon: the storm-chasing entrepreneur
Entrepreneur Secrets Serial entrepreneur Vincent Teubler, 47, embodies the saying "expect the unexpected". Teubler's "résumé" spans the spectrum.
Travel agent finds her niche in France
Entrepreneur Secrets At a time when many Australian tourism operators are doing it tough, Sue Heine considers herself fortunate.
The headache that sparked a $1.3 million idea
Entrepreneur Secrets Jack Fitzgerald had barely experienced a bad headache in his life but, three years ago at the age of 22, he suddenly developed one that lasted for years.
$100m software sold a year, not a single cold call
Asher Moses A billion-dollar business built by two Sydney friends in an apartment 10 years ago is widely tipped to be the first Australian tech start-up to go public.


text:
It's been the mother of all weeks thus far so the expression here seems appropriate! Was nice to finally get this one finished as it's been languishing in the remains of a sketchbook for the past three weeks. It's based on prints.
*This refuses to post any larger so click for detail!


text:
Sponsored by: Desert Diamond Casino
Feb 21, 2013 9:39 PM by Lupita Murillo
TUCSON - Next week, the federal sequestration takes hold with $85 billion, in mandatory cuts. That is unless there's a budget compromise. Cuts will start, automatically, next Friday.
Millions of jobs are on the line including those that protect our borders.
Art Del Cueto is a Border Patrol agent. He's also president of Local 2544 the Border Patrol Union which represents about 35,000 agents. "We understand we are going through rough times, but cutting down the security of our nation I don't believe is the way to go at it."
Homeland Security Secretary Janet Napolitano was in Nogales touring the border this week and said Border Patrol is now better staffed, having doubled the number of agents from 10,000 to more than 21,300 today.
Del Cueto says, "We have more agents but we don't have them doing border patrol work. We're actually helping out other agencies. Agencies that didn't receive additional personnel."
U.S. Customs and Border Protection recently sent an email to the National Border Patrol Council telling them about sequestration and the impact on agents, such as cutting overtime, and implementing a hiring freeze.
The day after that email was sent, a job posting went on the government website looking to hire Border Patrol Agents. The salary ranged from $38,000 to $63,000. "Why are they hiring these agents if they don't have the money to give these agents."
What really irritates Del Cueto about sequestration is neither Napolitano nor Congress are taking pay cuts.
"But the agents, that are truly putting their lives on the line, getting rocked, getting shot at, not having enough proper equipment, not having uniforms those are the people that are taking the hit," he says.
There's also mention of furloughs. Del cueto says, agents haven't had a uniform allowance since October. So many agents must buy their own boots to walk the rugged terrain of the Sonoran desert.
Border Patrol's budget is being slashed by $248 million.
1 hour ago


text:
Oct 22, 2012 8:36 PM by Kelly Orsini, KSBY News
A Santa Barbara man is in jail, accused of beating a man unconscious over the weekend.
Officers arrested Ran Tefft, 22, in the 500 block of Chapala Street just after 2 a.m. Saturday.
Witnesses said Tefft had punched and kicked a man during a fight at the intersection of Haley Street and Fig Avenue. Tefft told investigators the 26-year-old man had grabbed and broken his necklace, which he says was given to him by his late father.
Tefft was booked into jail.
The other man was taken to the hospital.
Offensive or inappropriate comments are subject to removal. To report a comment, please e-mail us at email@example.com, and include the name of the story and information on the comment.
Thank you! KSBY.com
3 hours ago


text:
Seventh Day Slumber Concert
Sunday, October 06, 2013, 6:00 PM - 9:00 PM
For directions click the following link: Lakeview Manor
Lakeview Manor of Fulton hosts Seventh Day Slumber with special guests Manic Drive, Submission Red, Havenstance and speaker Joseph Rojas Sunday, October 6 at 6pm. The concerts are sponsored by Cabin 3 Youth Group. For more information call 315-564-6133.


text:
Primanti Brothers is a chain of sandwich shops, founded in 1933. Locations are throughout Pittsburgh, Pennsylvania and its suburbs, with an additional three locations in the Fort Lauderdale, Florida area. Its signature items are its sandwiches, which consist of grilled meat, an Italian dressing-based cole slaw, tomato slices, and French fries between two pieces of Italian bread.
If YOU Love it, share your "Comments" with us on our Facebook page: http://www.facebook.com/waly1039
The original shop is located in Pittsburgh's Strip District, (READ MORE HERE.


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X-Rat is a labyrinth/arcade game full of action and logic.
*** AppAdvice said that: X-Rat Takes Labyrinth Gaming To New Levels.
link: http://appadvice.com/appnn/2011/05/xrat-takes-labyrinth-gaming-levels
*** Slide To Play said: It may look like a cute little puzzler, but this game isn't for the faint of heart.
link: http://www.slidetoplay.com/story/x-rat-review
*** AppSmile said that:X-Rat is a clever labyrinth-style game from CYCLONELAB that tasks you with leading a rat through complex mazes while collecting cheese and avoiding dangers http://www.appsmile.com/2011/05/25/quick-reviews/
FreeAppReport.com Featured App!
-Players Reviews-
It's easily amongst the best rolling-ball labyrinth games I've played. It's fine all the way through – level design, game mechanics, presentation, and music. Control response is a delight. It keeps interest well with clever level designs and the introduction of new kinds of enemies, obstacles or features (like switched gates and teleports) every few levels. It has some novel depth for a game of this kind, for instance being able to lure enemies and trick them into bumping each other off.
Not a "quiet" game though. The levels are timed but that's not it – the time limits are generous. It's the challenge of getting that poor rat through hectic levels full of death traps. Some levels seem almost impossible to overcome at first but come together rewardingly once you figure out a strategy.
-other McCoy (Australia)
Like labyrinth but funner!
– Chad-RS (United States)
Entertaining maze game with a cute theme, great art, and challenging obstacles. Please add tilt calibration option (and touch controls if possible!). Glad I caught this on slide to play .com or I would have never heard of this
-LobbyLibby (United States)
X-rat is a fantastic take on the labyrinth style, requiring fast reflexes, a sharp mind, and tons of patience as you'll inevitably be repeated crushed, drowned, electrocuted, and suffer every other imaginable indignity in the fine tradition of Nintendo Hard games, which just makes victory all the sweeter when you do get through. A very worthwhile purchase.
-Foxyshadis (United States)
Looks good, plays well, hard as nails. Easily worth 69p!
-Iphonechaos (United Kingdom)
Das Spiel macht sehr viel richtig, macht Spaß und unterhält eine Weile.
– Schön! (Germany)
– Manna890 (China)
– 水木子青 – (China)
Squitto, result of an experiment performed by a mad scientist has been abducted by a kind of evil aliens who enjoy to test its capabilities in a deadly maze full of enemies and traps.
Help Squitto! Tilt your device to move and find the way out of each maze as quickly as possible.
Make your way through obstacles, avoid traps and dodge laser guns fire. Lure and trick alien robotcrafts. Find and eat cheese, open doors, jump and run as fast as you can. Show the alien abductors you are smarter than them!
• 45 levels
• Physical Simulation
• Enemy AI
• Openfeint Leaderboards
• Facebook integration
• Original Soundtrack and Sound FX
• and more…
Coming soon:
• New level pack (15 additional levels)
• Survival Mode
gameplay trailer: http://www.youtube.com/watch?v=v9ZCgTb4_Ls
facebook page:


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TiVo to make version for those without cable
Here's a sign more households are going without cable or satellite TV: TiVo Inc. is making a digital video recorder just for so-called cord-cutters.
Here's a sign more households are going without cable or satellite TV: TiVo Inc. is making a digital video recorder just for so-called cord-cutters.
TV viewers increasingly are watching programs on their own schedule, according to a Nielsen company media study released Monday.
Dish Network is unveiling a new recorder system that can record eight TV shows at once, as long as four of them are from the broadcast networks ABC, NBC, CBS and Fox.
If you are on the road and want to watch live TV and recorded shows on your phone or tablet, there aren't many easy options.
The Xbox One won't quite replace your TV set-top box, but it comes awfully close. The latest game console from Microsoft takes a big leap toward being the main entertainment hub in your living room. It gives ...
Satellite TV company Dish Network says it has won a third federal court decision upholding the use of its Hopper digital video recorder, which allows viewers to watch recordings of hours of prime-time broadcasts with the ...
When I bought my first TiVo digital video recorder in 2001, I was a real trendsetter. "You can really pause live television?" friends asked with wonder. "You don't have to rewind a tape when you're done?"
TiVo Inc. wants to give television viewers more control over what they watch on traditional channels and over the Internet as the pioneer of digital video recorders unveils its fifth-generation devices.
Aereo is accelerating the expansion of its $8-a-month service providing broadcast television over the Internet.
(AP)—Aereo, which provides broadcast television over the Internet for $8 a month, says it will expand to Utah next month.
(AP)—Aereo, a startup that is trying to challenge cable and satellite TV packages with an $8-a-month offering over the Internet, says it will expand to Chicago in September.
For decades we've been watching TV. Now a new generation of televisions is beginning to watch us. Technological advances are giving the old clunky "boob tube" an IQ injection. Some of the new breed of smart TVs comes equipped ...
Aereo, the startup that offers television stations over the Internet starting at $8 a month, says it will start service in Atlanta on June 17.
Efraim "Efi" Arazi, a pioneer of Israel's powerful high-tech industry who helped develop technology that allowed for a video recording of the first moon landing, has died. He was 76.
(Phys.org)—A digital video recorder (DVR), used in homes and businesses for security, is helpful when not in the hands of criminals, The latter scenario is what is rattling some security blog and Forbes reader ...


text:
Breaking down the Class of 2014: Running Backs
The 2013 season was a great year for recruiting on the offensive side for Michigan State.
Before the rise of Jeremy Langford, the running back position was a big question mark for the Spartans. This year, MSU is adding some depth in the offensive backfield with three incoming freshmen.


text:
Results for cardiology Interventional Cardiology Moneta
Finding the right doctor is an important first step in managing your health and planning for your future. At LewisGale Regional Health System, you can choose from among the most experienced and highly trained physicians and healthcare professionals in their fields—over 700 doctors across dozens of convenient locations—and we can help you make the best choice.
LewisGale PhysiciansBrent W. Chapman, MD, FACC
400 Scruggs Road
Suite 2300
Moneta, VA 24121
(540) 719-0424
Map & Directions


text:
Home Congregations About Us Bookstore Press Room Giving
Page Navigation
Always face the person when you are talking to them. Most people who are hard of hearing rely on speech-reading to some extent.
Don't bend your head down while you're talking, because then your mouth is hidden. Keep your hands away from your face.
You don't have to talk loudly, or exaggerate the way you speak, but do speak clearly, without mumbling your words. Don't talk too fast.
Higher pitched women's voices are harder to understand; if you have a high voice, lower the pitch of your voice if you can.
Make sure the lighting is adequate, and try not to have bright light behind you when you talk so there is no glare, and your face isn't in shadow.
Background noise is a big problem for people who are hard of hearing and who, therefore, need to work harder following your conversation. Turn down music, turn off TVs and radios.
Hardwood floors, high ceilings, being situated in the center of a large room can all create acoustic problems. Choose a carpeted room and position yourself off to the side, or in a quiet nook.
Visual information helps. Use printed meeting minutes and agendas, flip charts, white boards, and Power Point presentations.
On Sundays offer printed texts of that day's sermon to people who are hard of hearing.
At meetings, it can be very confusing to follow the conversation if more than one person is talking at a time. Try to control multiple people talking at once.
Noise from phones, copy machines etc make it harder to concentrate. Try to schedule meetings and hold conversations in a quiet room, where the door can be closed and people can sit close together.
For more information contact access @ uua.org.
This work is made possible by the generosity of individual donors and congregations. Please consider making a donation today.
Last updated on Wednesday, April 20, 2011.
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Donate to Support This Program and the Ongoing Work of the UUA
Read or subscribe to UUA.org Updates for the latest additions to our site.
Learn more about the Beliefs & Principles of Unitarian Universalism, or read our online magazine, UU World, for features on today's Unitarian Universalists. Visit an online UU church, or find a congregation near you.


text:
National Festivals
National Kadampa Festivals are arranged each year in various countries.
These Festivals are taught by the Deputy Spiritual Director of the New Kadampa Tradition, Gen-la Kelsang Kunsang.
They are a wonderful opportunity for people to get together with fellow practitioners in their country to listen to teachings, practice meditation, and engage in discussion.
The proceeds from these Festivals are donated to the International Temples Project.
Date | Description | Check Back For Up Coming Events or Click For Calendar |


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Ok, this is the last photograph I am going to post from the weekend. During the shoot at Top Star yesterday, Alan and I decided to climb to the top of the Driving Screen which we did. It was SUPER dodgy and I cannot believe we are still alive and un-injured but we did it and I had to shoot a photograph at the top. I had an experimental weekend where I tried to basically break my camera gear by changing all the settings even more than I normally do and this was another result of that. The skyline was quite boring because of the time of day it was so I white balanced way off and then underexposed a bit as well as change a few otehr settings on camera. I have to go back and shoot a sunset there one day. I will, you'll see. Haha
Archives for April, 2008
Yesterday, Bloodline Ltd (the band) filmed a music video for one of their songs. They shot it at Top Star Driving and it was SUPER cold, SUPER windy and SUPER dusty so I didn't shoot much. I don't like getting dust and sand on / in my gear.
Anyway, I shot this photograph of a guy sitting on the bonnet of his car in between takes and hiding my camera in my bag. I had an idea in my head of how I imagined this to come out and tried to create it on camera by blowing out all the highlights and just boosting and dropping certain levels but it was a little rushed so it isn't completely what I had in mind but I do think it came out alright.
The Light
I have already posted a photograph of this street light before and I think that photograph worked well, but when I was shooting there again on saturday, the sky was super cloudy but so boring and grey. I decided to try something different and I shot this photograph with the white balance WAY off so that it would result in the entire photograph being blue. I like it.
Skating No More
On saturday, Rudi and I tried to hit up a skate session. It has been super long and I am not sure if the location was terrible or if it was just me but it seemed for the first time in my life that I actually didn't care much for it. Weird. I started skateboarding about 13 years ago and never once did I want to just pack up and leave. We did this and drove out to Nelson Mandela Bridge to try and shoot the sunset shots I have been wanting to do for ages. It rained so this never happened but we did get some good shots and it was just good fun being out there.
Mad Scientist
On set of the music video that I shot at yesterday for Zebra and Giraffe, I shot some photographs of an actor playing as a mad scientist. I love this portrait and everything about it. The "scientist" is standing in a lab set behind broken glass. The creator of the lab was Martin. I am so bummed that I don't know what his surname is because he deserves props for one of the craziest things I have ever seen in my life. SO much detail. Amazing. Please send me Martin's surname if you know it.
Filming the Knife
Zebra and Giraffe is ready to go and again I am going to push them because I think the album is awesome and going to do super well. Greg Carlin is the brains behind this project and this was my second shoot with him. I really like his ideas and am super excited to be working with him. He was filming a music video yesterday for his first single and these are some of the shots I got in between takes.
SA Photographers On a Sunday
Yesterday we had our second excursion as the SA Photographers Group and it was super fun even though we got rained out. Basically, a group of our friends has decided to try and go on little photography excursions at least once a month and then all post one photograph from the day that we can all crit on and hopefully this will help us all to learn a bit more and be excited about shooting.
Visit the site by clicking here and comment if you get the chance.
Zebra and Giraffe
The debut album for Zebra and Giraffe is going to be hitting shelves super soon and you really need to look out for it because it is amazing and definitely going to take off in a huge way. Greg Carlin is the mastermind behind the album and I shot some photographs with him on saturday for use with press articles about the album. These are just 4 of the bunch that I shot with him and they are honestly a bunch of my favourites. Remember Zebra and Giraffe or you will miss out.
Indulge in Cakes
I am busy working on a project for a new confectionery boutique that is opening up in Rivonia in the next month and a bit and the owners are really awesome. The company is called Indulge and they will specialize in wedding cakes and good confectionery as well as have a coffee shop to just sit and relax. I photographed a selection of their wedding cake options over the last week and I really was shocked at how amazing they were. I am just uploading 2 photographs as I am still busy logging them.
Indulge is coming soon, look out for them.


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For Travis Zajac, it's gotten to the point where I'm not even mad, I'm impressed. It's tough to avoid points when you get that much ice time.
Since the New Jersey Devils signed the young center to an eight-year, 46 million dollar contract ($5.75M cap hit through 2021) on January 16th, he's been nothing short of hot garbage.
I mean, the phrasing is a little harsh, but seriously, let's talk:
He averages over 20 minutes of ice time a night, a number only surpassed by Ilya Kovalchuk amongst Devils' forwards. And, he's played in all 27 of the Devils games this season. Some quick math, and that's 540 minutes, or nine hours on the ice.
He has four goals and four assists for eight points, good for tenth on the team. That's tied with Steve Bernier, and trailing Stephen Gionta and Ryan Carter, who combine to earn 36% of Zajac's salary (totalling $2.112M between them).
The last time he scored was February 24th, nine games ago, and incidentally, that was the last game in which he finished as a plus player. He's racked up a plus-minus of minus-10 since that game, only peppering in two assists along the way.
You don't give a guy a max-term deal at near six mill a season to not be your first line center, but here's what we're looking at as of today (from DailyFaceoff.com):
Instead, 22-year-old Andrei Loktionov (recently acquired for a fifth-round pick, makes $816k on his entry-level deal) is the guy lining up beside Ilya Kovalchuk, and sophomore Adam Henrique (854k, entry-level as well) gets Elias.
He has no goals and a solitary assist on the powerplay. He's only been used in a single shootout (missed). He's in the bottom half of the team in hits and blocked shots, if you value those stats.
He really only has few things going for him right now: he's winning a lot of faceoffs (56.8%, to be exact), he's driving play alright (9th on the team in Corsi, 9.82), and his shooting percentage is low-ish at 7.5%, so we could expect a mild uptick there (that contributes to his 979 PDO). But the black and white (and red) or it is, it's been a nightmare season aside from that whole getting rich thing.
The Devils have posted a couple wins after a rough stretch where they went 0-5-1, but they still have a tenuous grasp on a playoff spot, and need their best players to be their best players. If they hope to hang on and squeeze in, they're gonna need more from Zajac.


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Chevrolet Monte Carlo 2006 and Newer
chevygirl Posts: 18Hey all! Just bought my new Monte last week- 2006 LS, black on black! Fun to drive, handles well, hauls on the highway, room for 5, plug in your ipod... it is the nicest car I have ever been in! I paid $100 over invoice, got the GM extended warranty to 75,000 miles at S plan pricing, got $500 trade in assistance, even got 4.9% financing... If you are thinking about this car, I would recommend checking it out! I love mine!
Holly -
blacktie Posts: 1Turbo it, add an intercooler, exhaust cutouts and larger injectors. Now, its a "Grand Monte Carlo" much like the Buick GN's of old. I've done it and it'll eat Mustangs, Vipers and Corvettes. Don't believe me? ~ Check out a Pontiac GP 4 Door set up this way doing a 1/4 mi in [11.47 sec. @ 116.12 MPH] at my site: :P
'89 BEASTSTANG's CARCRAZY">link title
Here's my 'Monte: :shades:
BlackTie -
observer22 Posts: 41Two years ago Edmunds did not have an active Monte discussion. I test drove the base 04 Monte and found it to be a comfortable cruiser with fairly ugly styling and a lousy engine with problems (3.4).
That 04 Monte Carlo had a dash with some styling cues from the classic 70-72 Montes. It also had seats (base version) that seemed the equal of Volvo's (I did test drive a Volvo during the same period). Chevy borrowed Toyota technology for a frame immediately behind the dash. And copied Hyundai in making the rear side panel one piece. Don't forget those great crash test scores.
Now all of the good stuff (except for the dash styling) is mated with much better front end styling and a more reliable, more modern engine. The 06 Monte Carlo should have been the 2000 version. -
quietpro Posts: 702Well, of course Monte Carlo sales are falling. You can't expect a stale design to continue selling. I would've likely traded my '02 for an '06 but I didn't want the "same" car. I ended up with the Impala SS but already miss my Monte Carlos "B" pillar that didn't direct air into my ear while driving with the windows down. I also miss the sportier seats in my old Monte Carlo. Monte Carlos will sell again if they would only restyle it. As for the Camaro taking over the coupe slot, there is room for both if both are great cars. I like Camaros but would choose the Monte Carlo for higher comfort levels. Chevy used to be able to sell multiple lines of cars. Toyota does it today. As long as they all are quality built and have their distinct place in the lineup, the sales will follow.
Karen_CM Posts: 5,035A national personal finance magazine is looking to interview consumers who own a car which has cylinder deactivation technology and is happy/unhappy with the fuel mileage it receives. Please send an e-mail to firstname.lastname@example.com no later than Monday, July 3, 2006 by 2:00 PM PST/5:00 EST containing your daytime contact information and what car you own.
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Edmunds.comCommunity Manager If you have any questions or concerns about the Forums, send me an email, email@example.com, or click on my screen name to send a personal message.
sacstate1 Posts: 189Why would I want to spend my hard earned money on a rental car? Same with the Impala and other GM clones. When GM starts selling to individuals and not corporate rental fleets I might be interested in GM again.
Front drive, muscle car (SS)? Get real. That turn signal is the same design I had on my '82 Z28 when I was in High School. -
exalteddragon1 Posts: 735These cars look better now than they did B4 from some angles. The problem is that its the same car in side and out with a new radio and some new engines. It should have been redesigned like many here say.
Its sad that GM is gonna retire yet another great name. Good thing the Camaro is comming back.
The values of these things are also gonna drop if they stop production. -
uplanderguy Kent, OHPosts: 7,714There are a couple things I wish GM would do/would have done with the current Monte:
1) Put some chrome trim inside the taillights a la Nissan Altima...would spruce up the rear.
2) I cannot understand how starting with either the '04 or '05 model (can't recall which), they took the bodyside molding off, and it's not even an option! Makes the car look bloated, not to mention susceptible to parking lot dings! If I bought a new one, I'd have the dealer body shop install the moldings from the earlier car and charge me for it!
Bill P. from OH -
zepp_leppard Posts: 1I'm not sure what u have heard about the 06 monte SS, but it will eat up a new mustang GT. I traded in my 02 SS on the 06 and have had the pleasure of beating lots of mustangs, suped up GTP's, nitrous civics and hemi chargers. The RWD drive have traction issues off the line and i can take 3 lengths on them and usually hold it. I beat a beautiful black hemi charger last night, not by 3 lengths but a length none the less, nothing like seeing a losers headlights in your rear view. WHATEVER you have heard about not being in the same ball park is pure BS, this thing pulls so hard it is hard to explain, it hauls [non-permissible content removed], believe me, i have made some people very sad after they revved thier motors at me. Just because you read numbers in a magazine doesn't mean squat, GM did an awesome on this 5.3 V-8, nice rumble, revs like a frikkin f-1. As far as i'm concerned the Mustang GT is totally overrated.
stim001 Posts: 1I've recently read that Chevy will again lose the Monte Carlo line! What's up with this? Sales down? Can't sell em? I don't think they're trying hard hard enough! Every other model (well all most every other one) has massive incentives! Thousands off better rebates Etc, Etc, Etc. but every time I've tried to purchase a Monte they are higher priced than most people are willing to pay. I've owned 4 of the 6 generations, and have loved each one more than the next. My newest is a 2006 SS. I'll tell you all that this the hottest thing I've ever owned! It'll do 0-60 in less than 5 sec and without the traction control I'd burn the tires right off the beast! The MC I traded for it was a 2004 Supercharged SS. It had a good top end but it doesn't even compare to this 06! Now I've read where Nascar/GM is going to an Impala SS. Don't get me wrong I "Like" the Impala but I and so do alot of others "Love" the Monte Carlo! I hope it won't come to that again but.... I guess we'll see huh? Hey not everyone in this country is married with 2.5 kids! Two doors vs 4 I'll take the two!
nicklesage2000 Posts: 1I bought a used 06 Monte Carlo with the 3.9L about three months ago. At first I really liked but I have started to notice creaking and cracking noises coming from the dash and the door panels. I have taken it into the dealership and they have basically told me that this is the way the car is made. Just wandering if anybody else has experienced these same things. My wife seems to think that it is because I am crazy, but I still here it and it is driving me crazy. Any suggestion or comments?
observer22 Posts: 41I noticed that the seats in the non-SS Montes are not as comfortable in the slightly redesigned 2006 and newer Montes as the seats in the 2000-2005s. The 2000-2005 base and mid level Montes had seats that rivaled Volvos for comfort.
The good news for you is that the 3.9 is a much better engine than the troubled and dated 3.4 the Monte had from 2000-2005.
Be very specific about the noises that are driving you crazy. If you don't know where it is coming from or are not 100% sure, then tell them when and at what speed the sound occurs.
Example: once I owned a hatchback that had an intermittent squeak. I would insist to the dealer it was a problem with the hatchback's rear upswinging "door". The squeak was actually in the rear seat mechanism that held it upright on one side.
Anyone buying the evidently now discontinued Montes should bargain hard and be patient. Resale will be awful, perhaps almost at lowly Saab levels. -
snowandtorque Posts: 4I like the overall design and function of the new Monte Carlo. The sales are dropping on the Monte because they have no sales group particularly. Kids who want the speed and hoursepower think they are out of the movies, and go out and buy their little 100 hp civics and little rice burners like everyone else. It is a large 2 door car, with a V8 (well v6 if you don't have the SS) The Monte has a select market type. People like me who like it and respect the HP have kids and can be won over by the Impala due to having 4 doors. It is just a hard market out there for a large sized, 2 door V8 car. Alot harder than a 2 door gas sipper, or a 2 door small coverible coupe with 200 HP, or even a high powered 4 door sedan. Think of the Solara, or other like style cars....they have sales issue too, and Toyota pretty much owns the market right now for car sales. GM for the first time in a long time reported a profit, so if the best selling car in America (yes I hate to say it, but it is true) Toyota can't sell a large 2-door sedan, how can our beloved Chevrolet do it....I think they (short of small mods we would all like to see) Have designed the Monte in the best profitable way possible....."hey guys...we aren't selling these....what can we do to make our fellow Americans buy it?.........throw a big [non-permissible content removed] engine in it as an option...yeah that will do it" Hey it turned my head....haha
veeeeryunhappy Posts: 1yes i have a 07 model we bought about 5 month's ago we did'nt notice the paint comming off until about a month after we bought it the dealer wicth is royal oak's of paducah,ky said that we have gotten something on the paint but there is no way and they will not fix it there is a noise in the steering and the door's are rattling the stereo wont turn up right when you turn it down then it get's louder i dont think the car drive's as good as the other 5 monte carlo's i have owned.
karenpenn Posts: 2:mad: & :sick: I bought an 06 SS and I have had nothing but problems with it. I have replaced the dash twice and it is now coming apart again. The power steering pump is going out. There are creaking and cracking noises coming from up under my car. The back end had to be repainted, the tire sensors are constantly going off. I have never had this many problems with a vehical and Chevy will not do anything about it but give me the run around. I did not pay $32,000 for a car to end up in a rental all the time. So I know what you are going through.
karenpenn Posts: 2:mad: & :sick: I bought an 06 SS and I have had nothing but problems with it. I have replaced the dash twice and it is now coming apart again. The power steering pump is going out. There are creaking and cracking noises coming from up under my car. The back end had to be repainted, the tire sensors are constantly going off. I have never had this many problems with a vehical and Chevy will not do anything about it but give me the run around. I did not pay $32,000 for a car to end up in a rental all the time. I have test drove other 06 SS and the dashes in them were also lifting up. BE CAREFUL ABOUT BUYING AN 06 SS
defyant Posts: 1I recently purchased a 2007 Monte Carlo and was dissappointed to find the Chevy emblem on the airbag/horn cover was dented. Apparently the entire airbag has to be replaced to correct this visual defect. I researched and found other Chevy's have this same problem. The dealer claims because it is not recalled that it can't be fixed under the warranty. Has anyone else had this problem? Does anyone have any creative ideas on a way to cover that center emblem? I think Chevy could make a simple stick on replacement cover. I hope to hear some feedback.
redrider06 Posts: 2
redrider06 Posts: 2
new06owner Posts: 6
hatemy06ssmc Posts: 2Completely frustrated with my 06 Super Sport. It has 40k on it and at 15k the power steering went out, front bumper had to be repainted and now at 40k my power steering is on the #@*% list once again. 4 thousand miles out of warranty and I can not believe from what I have read on here that GM has not issued a recall on these vehicles. I went to their website to research recalls and the corvettes and silverados all have recalls on the steering issues. Has anyone else had a repeat of the steering going out? PLEASE REPLY!!!!!! Common sense tells me that a ma jority of these vehicles have all the same componenets as far as PAINT, POWER STEERING HOSES, PUMPS, STEREOS................. With the history I am really hoping that GM fixes my car at no expense to me because my husband wants a Vette!!!
hatemy06ssmc Posts: 2
new06owner Posts: 6
new06owner Posts: 6
thankgoditsav8 Posts: 2I bought an ' 06 new. So far, so good. Your question about the rally stripes may have been answered for you already. The ' 06 did'nt have that option available, but the ' 07 did. Your car, although, may have had that update added as I've been thinking about doing the same to my SS. A dealership bodyshop would be able to tell if it's a GM update. Hope that helps.


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HoopsHype Andrew Nicholson rumors
The Orlando Magic have signed rookie forward Andrew Nicholson, General Manager Rob Hennigan announced today. Per team policy, terms of the deal are not disclosed. NBA.com
Evan Dunlap: St. Bonaventure coach Mark Schmidt has used the word "tremendous" at least six times describing Nicholson's offensive skill. Twitter
Adrian Wojnarowski: Nicholson will be the Bonnies first 1st round pick since Bob Lanier was selected first overall in 1970. Twitter
Andrew Nicholson is a hot name right now as teams in the late lottery are considering him and there's an excellent chance that he will land somewhere in the teens on draft night. There are a number of teams attempting to move up for him, and it's unlikely that he would fall past Orlando at 19 or Denver at 20. We hear OKC is one team that could be looking to add a mid-first rounder to grab him, with Eric Maynor as possible trade bait. NBADraft.net
The Heat also have a first-round pick, No. 27, this week that they are expected to use on a backup big man such as Fab Melo of Syracuse, Andrew Nicholson of St. Bonaventure or Festus Ezeli of Vanderbilt depending on who might be available. ESPN.com
Tom Moore: Evan Turner & Xavier Silas worked out after #Sixers predraft session. Lavoy Allen chatted with former A-10 rival Andrew Nicholson. Twitter
The Sixers, who have the 15th, 45th, and 54th overall picks in next week's draft, will bring in five more players Saturday, all of them big men. The group includes: John Henson, a 6-10 forward (13.7 points, 9.9 rebounds, and 2.9 blocks per game), and Tyler Zeller, a 6-11 center (16.3 ppg, 9.6 rpg, 1.5 bpg), both from North Carolina; Baylor 6-10 forward Perry Jones (13.5 ppg, 7.6 rpg); Mississippi State 6-10 forward Arnett Moultrie (16.4 ppg, 10.5 rpg), and St. Bonaventure 6-9 forward Andrew Nicholson (18.5 ppg, 8.4 rpg, 2.0 bpg). Philadelphia Inquirer
The Monday workout will also feature guard Cameron Tatum (Tennessee) and forwards Kevin Jones (West Virginia), Kris Joseph (Syracuse) and Andrew Nicholson (St. Bonaventure). Memphis Commercial Appeal
Two power forwards trending in opposite directions right now are Ohio State's Jared Sullinger and St. Bonaventure's Andrew Nicholson. Sullinger's stock appears to be plummeting after NBA doctors "red flagged" his medical report because of concerns about his back. There is at least a slim chance Sullinger could be available now when the Cavaliers select 24th. Akron Beacon Journal
The Nuggets welcomed four other draft prospects to the Pepsi Center on Monday, including 6-foot-9 forward Andrew Nicholson, a possible first-round pick from St. Bonaventure who averaged 18.5 points and 8.4 rebounds last season. Iowa State's Royce White rescheduled his Denver workout for next week, so the Nuggets brought in Colorado forward Austin Dufault to create three-on-three competition. Also in Denver were 6-6 guards Will Barton of Memphis and Kevin Murphy of Tennessee Tech. Denver Post
With the 2012 NBA Draft approaching, the Denver Nuggets evaluated six college prospects at Pepsi Center on Monday. Among the group was University of Colorado power forward Austin Dufault, a four-year starter who played in a school-record 136 games. It was Dufault's first NBA workout. "It's awesome (to be here in Denver)," Dufault said. "Over the last four years, I've turned into a Nuggets fan because they've been down the road (from Boulder). I've been to a couple of games and I'm familiar with their coaching staff. Just being able to come here and work out is a blessing and it's an opportunity that I'm very thankful for." Dufault was joined by Memphis guard Will Barton, Tennessee Tech guard Kevin Murphy, St. Bonaventure forward Andrew Nicholson, Kansas guard Tyshawn Taylor and Kentucky guard Marquis Teague. NBA.com
On Tuesday, the Suns worked out two big men who also are first-round candidates. In that workout, St. Bonaventure's Andrew Nicholson outshined Syracuse's Fab Melo, but neither is considered in the realm of Saturday's bunch, although Nicholson's stock is rising. Arizona Republic
Paul Coro: The #Suns held their first draft workout today. The group featured Syracuse C Fab Melo & St. Bonaventure PF Andrew Nicholson. Twitter
One general manager was wowed by St. Bonaventure's Andrew Nicholson, saying that Nicholson was using words during his interview that he didn't even know. It was tongue and cheek, but the point was that Nicholson is a mature player who will win over teams with his high character. Expect him to fall somewhere in the No. 21 to No. 24 range. ESPN.com
Chad Ford: Who impressed at #NBACombine ? Damian Lillard, Perry Jones, Terrence Ross, Meyers Leonard, Moe Harkless, Andrew Nicholson, Jared Cunningham Twitter
Any rumor missing? E-mail us at email@example.com.


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German prosecutors said Wednesday's attack on U.S. Air Force security personnel aboard a bus outside Germany's Frankfurt Airport appears to be motivated by Islamic extremism.
Two U.S. airmen were shot and killed in the attack. Two others were wounded.
Eyewitnesses said the terrorist shouted "jihad, jihad" as he began firing.
The shooter was identified as a 21-year-old legal German resident who worked at the airport. Officials said the shooter was a Muslim immigrant from Kosovo.
The military said the airmen were traveling to Ramstein Air Base, where they were to be deployed to support an overseas operation.
"I'm saddened and I am outraged by this attack that took the lives of two Americans and wounded two others," President Barack Obama said.
At least 12 U.S. military personnel were on board the bus, parked just outside the international terminals.
German authorities said the gunman walked up to the bus, began arguing with some of the airmen, and then pulled out a gun and started firing while shouting "Allahu akbar," Arabic for "Allah is great."
After firing nine rounds, his gun jammed.
"I want everybody to understand that we will spare no effort in learning how this outrageous act took place," Obama said.
German Chancellor Angela Merkel vowed to do everything possible to investigate the incident.
The alleged gunman's family released a statement, saying they could not imagine how something like this could happen, because they feel Americans are their brothers.
The gunman is in custody, but German authorities will continue their investigation Thursday to see if the shooting is linked to a larger terror plot.
Two U.S. Airmen Killed in Frankfurt Shooting
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ATLANTA, Oct. 24, 2012 — Some of the nation's busiest airports are — or were — also home to the most Transportation Security Administration (TSA) agents fired for theft, according to a new report from ABC News.
With 29 employees fired for theft between 2002 and 2011, Miami International Airport (MIA) topped the list, according to ABC News. JFK International Airport (JFK), Los Angeles International Airport (LAX), Hartsfield-Jackson Atlanta International Airport (ATL) and Las Vegas-McCarren International Airport (LAS) rounded out the top five, according to the ABC report published Tuesday.
Critics have long bemoaned the TSA as a bureaucratic mess while supporters say the federal agency, founded in the wake of the Sept. 11, 2001, terrorist attacks, is necessary to ensure the flying public remains safe. The report is the latest in a string of bad news for the federal agency.
On Friday, TSA officials said they want to fire 25 employees and suspend another 19 at Newark Star-Liberty International Airport (EWR) after the employees failed to properly conduct baggage screening, according to the TSA and published reports.
Earlier this month, the agency's Inspector General (IG) recently found shortcomings in the TSA's procedures, standards and oversight at Honolulu International Airport in 2010.
"I lay the blame at TSA because it's a bureaucracy that doesn't know how to manage an army of 65,000 employees," U.S. Rep. John Mica, R-Fla., said in a statement last week following the Newark airport announcement. "When are we going to learn that the problem is that this massive, bloated bureaucracy is in need of dramatic reform?" Mica added. "Every new security lapse, each one worse than the previous, demonstrates more that this agency is in disarray, and we must transform the TSA from a vast and unsuccessful human resources operation into a true security agency."
Mica isn't alone. In June, U.S. Rep. Paul Broun, R-Ga., suggested dismantling the TSA, a move he said would have saved taxpayers more than $5.5 billion.
His push fell short, and it wasn't the first time the Congressman criticized the agency. In May, Broun asked John Pistole, administrator of the TSA, to resign, saying in a letter the federal agency "has become nothing more than a bloated, broken bureaucracy."
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