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Ofran, Yishaia,b; Rowe, Jacob M.a,b
aDepartment of Hematology and Bone Marrow Transplantation, Rambam Healthcare Campus
bBruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Correspondence to Yishai Ofran, MD, Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel. Tel: +972 4 8542541; fax: +972 4 8542343; e-mail: firstname.lastname@example.com
Purpose of review: Despite enormous progress in the understanding of leukemia pathophysiology and novel transplantation protocols, the prognosis following acute myeloid leukemia (AML) relapse is still uniformly poor. In the current review, advances in risk stratification, protocols involving novel agents and allogeneic stem cell transplantation (ASCT) will be discussed in light of the vision of personalized therapy.
Recent findings: The role of ASCT in relapsed/refractory AML is well established and has been recently confirmed as mandatory for cure. Retrospective observations of different large cohorts categorized patients with early relapse, poor cytogenetics or fms-like tyrosine kinase receptor-3 internal tandem duplication mutation as the most challenging population. Multiple novel agents have been studied with various promising results; however, these agents can only serve as a bridge to transplantation. If ASCT is not an option, therapy should focus on prolongation of patient's life at its best possible quality. Accumulated molecular data open new horizons for personalizing therapy and assigning each patient to the drug or protocol from which the patient will benefit most.
Summary: Relapsed/refractory AML is a heterogeneous disease and no uniform protocol will provide cure to all patients. Molecular tests may contribute to future personalizing therapy resulting in improved outcome. Meanwhile, novel and more effective induction and postremission protocols are warranted to lower the relapse rate.
For acute myeloid leukemia (AML) patients who enter complete remission, maintaining remission is an imperative. The probability of relapse depends on the leukemia's molecular profile, patient's age and the type of postremission therapy administered. Moreover, with current intensive protocols, up to 20–30% of young and 40–50% of older AML patients will experience primary induction failure. Despite enormous progress in the understanding of leukemia pathophysiology, the prognosis following relapse is still uniformly poor and novel approaches are desired for the treatment of relapse.
Molecular and genetic methods enable the detection of scant leukemic cells reappearing in a morphologically normal bone marrow. The current review will discuss up-to-date therapies and how to interpret results of molecular tests in relapsed/refractory AML.
Only about 10% of patients survive after a relapse in AML [1,2]. For those select patients who have survived the relapse and responded to intensive reinduction therapy, AML may be curable by allogeneic stem cell transplantation (ASCT). However, physicians are often reluctant to administer aggressive therapy due to the unavoidable therapy-associated neutropenia and thrombocytopenia, especially in older patients. Nevertheless, susceptibility to infection and bleeding is often related to the nature of the disease per se. Of note is the fact that intensive chemotherapy goes together with and does not contraindicate palliative therapy [3]; alleviating suffering and symptoms is fundamental in any protocol, regardless of its curative intentions.
Prognostic factors predicting outcome following intensive chemotherapy for relapsed AML have been recently reported by two large retrospective studies of 1015 Japanese patients [4▪] and 138 patients from France and Israel [5▪]. An equivalent overall survival rate of 30% at 3 years and 36% at 2 years was reported. Patients were treated with cytarabine and anthracycline combinations and with addition of gemtuzumab ozogamicin in the French study. Early relapse (<1 year after complete remission 1) and unfavorable cytogenetics were poor prognostic markers in both series. The presence of fms-like tyrosine kinase receptor-3 (FLT3) mutation was evaluated only in the French study and was found to independently predict for a poor prognosis. Importantly, contrary to previous works [1,6], age was not a significant prognostic marker in both series. Those previous publications included patients younger than 60 years of age and within this group, younger patients did better. Recent works enrolled patients of all ages and demonstrated that patients younger or older than 60 years of age did as well with intensive chemotherapy. This must be very carefully considered, as the more common practice of many clinicians is to be aggressive with intensive chemotherapy for patients in their 50s, while hesitating in administering the same protocols to patients 10–15 years older. As in newly diagnosed AML [7,8], the data for relapsed AML suggest that although outcome of elderly patients is generally worse, some do benefit from intensive chemotherapy.
Chevallier et al.[5▪] went a step further and created a prognostic score and validated it in a different group of 111 patients. The score that contains only three adverse factors (early relapse, FLT3 mutation and poor cytogenetics) discriminates well between patients with 0–1 and those with 2–3 adverse factors. The 2-year overall survival (OS) following intensive chemotherapy was in the range of 23–58% for low-score and 0–12% for high-score patients. This scoring scale encourages prescribing intensive chemotherapy for patients with low scores but should be carefully interpreted when treating relapsing patients with high scores. In the above-mentioned Japanese study [4▪], achievement of second remission and salvage ASCT emerged as the most important factors predicting longer OS. In the validation French cohort, patients with high-score relapse had a grave prognosis following intensive chemotherapy. However, the portion of patients who achieved second remission and proceeded for ASCT was not reported and might be low, as the validation cohort came from the LAM (lamivudine)-2001 trial [5▪], which included patients with no matched siblings.
Complete remission is fundamental for cure in first-line therapy of AML [9▪▪]. Failure to achieve a second remission in relapsed AML was recently demonstrated to be associated with reduced OS (hazard ratio of 3.23) in a large retrospective study [4▪]. Most clinicians agree that intensive chemotherapy aiming at second remission is appropriate in patients with good performance status, late relapse, no adverse cytogenetic or genetic markers and significant bone marrow blast counts [10,11]. For patients with early relapse, especially if poor cytogenetics or FLT3 mutation are present, chances to enter second remission with intensive chemotherapy are as low as 20% [12▪]. Moreover, with different reinduction protocols the 30-day mortality rate is as high as 20% [4▪,13–15]. Therefore, in patients with high-score relapse, intensive chemotherapy targeting second remission may be considered futile.
What should be offered to patients in whom an attempt to reach second remission is not considered? If cure is aspired, ASCT must be considered mandatory. Otherwise, the goal of therapy may be prolonging life of the best quality possible.
Conditioning protocols and donor selection in relapsed AML have been recently reviewed [16]. We will herein focus on patient selection for ASCT in the challenging clinical setting of relapsed AML when second remission has not been achieved. Scoring predicting transplantation success was developed in a retrospective survey of 1673 patients who underwent a myeloablative ASCT for AML in relapse. Patients with a very low score were demonstrated to experience a 3-year OS of up to 42% and those with a very high score had a dismal prognosis with only 6% alive at 3 years [17▪▪]. Unfortunately, the high score refers to the same group of patients in whom attempts to reinduce second remission are likely to fail. Patients with a short complete remission 1, poor cytogenetics, low performance status and/or circulating blasts present a major clinical challenge. These patients have a low OS rate when proceeding directly to ASCT, but chances to improve it by inducing second remission are also scarce and the impact of significant toxicity associated with induction regimens should not be underestimated. An interesting strategy of cytoreductive chemotherapy, followed by reduced-intensity conditioning (RIC) and prophylactic transfusion of donor lymphocytes in refractory and early relapse patients was created [18]. This German protocol known as the FLAMSA (fludarabine, Ara-C, amsacrine)-RIC protocol was reported in a prospective multicenter study involving 103 patients. The study recruited patients with early relapse and primary induction failure. The median survival of 16.4 months and the 4-year estimated OS of 32% are promising. The concept of the FLAMSA-RIC protocol inspired similar other sequential cytoreduction followed by RIC transplantation protocols with encouraging results [19–21]. This approach requires an HLA-matched donor available just when relapse is diagnosed. Therefore, for AML patients in complete remission 1 even if allogeneic transplantation is not scheduled, a search for a matched donor should be initiated to enable sequential transplantation in case of early relapse.
If no matched donor is available, cure may be accomplished by double umbilical cord or haploidentical ASCT, but with a very low success rate if transplanted not in remission [22▪], similar to the data when using matched unrelated donors [23]. Select patients may be cured with intensive chemotherapy followed by an autologous transplant [24]. In chemorefractory relapses when a matched donor is not available or the patient is unfit for ASCT, therapy should target prolongation of life instead of curing the disease. The ultimate objective of getting patients into remission should, therefore, be replaced by controlling leukemia and intensive chemotherapy by continuous chronic therapy with minimal side effects. For some patients such therapy will buy time until a suitable donor is available (bridge to transplantation). In other 'unfit' elderly patients, therapy that will yield significant prolongation of life of an acceptable quality will be favored.
Hydroxyurea, 6-mercaptopurine and low-dose Ara-C are old drugs with proven ability to control leukemia for a limited period of time. Novel agents and strategies in relapsed AML have been reviewed by Litzow [25]. Herein we will update those agents that have been shown to be effective in controlling leukemia in recent years and discuss benefits and drawbacks of each agent.
Clofarabine is a novel purine nucleoside analogue structurally similar to fludarabine and cladribine, developed with the aim of avoiding the neurotoxicity that limits the maximal tolerated dose of old-generation purine analogues. The role of clofarabine as intensive chemotherapy has been evaluated in several successful phase I/II studies [26▪,27]. A phase III study (ECOG-E2906) comparing clofarabine with traditional 7+3 (daunorubicin and cytarabine) as induction in newly diagnosed older patients with AML is currently recruiting. The efficacy of single-agent low-dose clofarabine or combined with other drugs in controlling relapsed or refractory leukemia has been evaluated [28], but so far with no significant breakthrough.
Mutation in FLT3 is well known to be a poor prognostic marker in newly diagnosed and relapsed AML [5▪]. Specific inhibitors of FLT3 such as sorafenib, lestaurtinib (CEP-701) and quizartinib (AC220) have been studied in relapsed or refractory AML. The largest trial was a phase III randomized trial of salvage chemotherapy with or without lestaurtinib, which failed to demonstrate a general benefit from the addition of lestaurtinib [29]. However, the target inhibition of FLT3 was achieved in only 58% of patients receiving lestaurtinib, although good inhibition did correlate with longer OS. Sorafenib was demonstrated to slow down disease progress in relapse but cannot induce second remission [30]. Quizartinib (AC220) is probably the most effective FLT3 inhibitor and results of large-scale trials in relapsed AML are still pending [31]. However, interim analysis of a phase I/II study has demonstrated that quizartinib provides clinically meaningful reductions in marrow blasts and successfully bridges to ASCT in a substantial proportion of patients [31].
Mammalian target of rapamycin (mTOR) was identified in vitro as an attractive target for therapy. Furthermore, gene expression analysis pointed to the AKT/mTOR signaling pathway as involved in Ara-C responsiveness [32]. Preliminary encouraging results were reported with deforolimus, sirolimus or everolimus [33–35], alone or in combination with other drugs, but confirmation in large-scale studies is warranted.
Hypomethylating agents are active in high-risk meylodysplastic syndrome but to a lesser degree in highly proliferative AML. 5-Azacitidine was shown in one study to prolong OS in elderly AML patients with low proliferative disease [36▪], and hence has drawn attention as an agent that may control low proliferative relapses. Indeed, a small retrospective study of 26 patients demonstrated that absence of peripheral blood blasts is the strongest predictor for OS in patients relapsing after ASCT. Interestingly, bone marrow blast counts of more than 20% failed to predict response in both this and other trials [37]. Responses, however, were observed in the minority of relapsing patients and were of short duration. If given with first signs of molecular relapse, azacitidine may delay relapse and allow some patients to proceed to ASCT [38].
Lenalinomide is an immunomodulatory agent with known activity in multiple myeloma. High-dose lenalinomide induced second remission in five of 31 (16%) patients, all of them with low proliferative relapse [39]. Trials combining lenalinomide with chemotherapy or hypomethylation agents are ongoing.
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspases 3 and 9 and is overexpressed and promotes chemoresistance in AML. AEG-35156 is an antisense oligonucleotide that targets XIAP. AEG-35156 at a dose of 350 mg/m2 was well tolerated and effectively knocked down XIAP expression. Combination of XIAP with chemotherapy yielded complete remission/CRp in 91% of patients who had been refractory to a previous induction chemotherapy [40].
Immune therapy for AML has been reviewed elsewhere [41]. We will herein discuss recent studies highlighting the immune therapy potential in relapsed AML. Vaccination with Wilm's tumor (WT)1 antigen-targeted dendritic cells induced complete remission 1 in two chemorefractory patients who achieved only partial response with induction protocol [42▪▪]. Adoptive transfer of T cells directed against different recipient minor antigens induced remission in seven AML patients relapsing after ASCT [43▪▪]. Most interesting is a study on infusion of HLA-mismatched stem cells that improves complete remission 1 and OS rates in elderly patients probably through an immune modulation mechanism [44▪].
With no consolidation therapy, all AML patients in complete remission 1 eventually relapse [45], suggesting that at least during the first months of therapy, undetectable minimal residual disease (MRD) exists in all patients. Traditional definition of chemorefractory AML requires the morphologic presence of 5% blasts in a bone marrow smear after recovering from conventional induction or reappearance of blasts in less than a year after achieving complete remission 1 [46]. New sensitive molecular techniques allow detection of sparse malignant cells or DNA, but does detection of MRD always predict for refractory disease? Two debates should be addressed to create an updated clinically meaningful definition of refractory AML.
First, how long after induction are molecular signs of MRD permissible? Rapidity of MRD eradication is a good prognostic marker in acute lymphoblastic leukemia [47]. In AML, rapid clearance of blasts and early reduction of WT1 transcripts from peripheral blood [48,49] predict for a good prognosis. The clinical challenge is how to consider patients who delayed but eventually attained complete remission. The presence of bone marrow blasts at day 14 of induction is definitely a surrogate marker for refractory AML. If reinduction was delayed until day 21 [50], prognosis is poor. Yet, with immediate reinduction, some patients will be rescued and OS for those who eventually attain complete remission is equal to those patients who obtained complete remission with single induction [51▪▪].
The second debate is whether any level of MRD justifies reinduction and ASCT [52▪]. The common wisdom is that leukemic cells should be completely eradicated. So, responding to any sign of molecular relapse should give patients a better chance for cure and a longer survival. This assumption probably will never be confirmed in prospective randomized trials because the 'watch and wait' approach ignoring molecular relapse may be considered unethical. A recent observation highlighted the contribution of a patient's own immune system to preventing relapse probably through its capacity to eradicate undetectable MRD. In 143 adult patients with AML in complete remission 1, adenine-adenine polymorphism in the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene was associated with higher incidence of leukemic relapse than the adenine-guanine polymorphism (56.4 vs. 35.6%, P = 0.004, respectively). This was translated to a lower overall survival at 3 years (39.4 vs. 68.4%, P = 0.004) [53▪▪]. One can speculate that some patients may be cured even if not all leukemic cells have been eradicated by chemotherapy.
Despite multiple novel agents available, prognosis of patients with relapsed AML remains poor. Progress in understanding molecular pathophysiology of AML may hold the key for future treatment approaches promoting proper assignment of patients to the most beneficial therapy. Advances in pharmacogenetics may in the future help identify such patients. This may direct clinical research into smaller trials focusing on genetically discriminated subgroups [32,54]. The above-mentioned CTLA4 polymorphism is an example of a potential path for personalizing therapy in AML. Immunotherapies may turn out to be more beneficial for patients with active CTLA4 polymorphism. Specific small molecules such as FLT3 inhibitors are only indicated in FLT3-positive AML and are most effective if significant FLT3 inhibition is achieved. Azacitidine is more likely to control disease in Ten-Eleven translocation 2 gene-mutated AML [55▪]. The personalized approach is promising but will bring about new challenges for treating physicians. Clinicians will have to switch their perspective from a general 'best available' protocol to sophisticated integration of multiple parameters. A meticulous workup will be mandatory to select the best protocol matching patient's condition, biological and genetic factors, and considering patient's wishes within a realistic context.
There are no conflicts of interest.
Papers of particular interest, published within the annual period of review, have been highlighted as:
▪ of special interest
▪▪ of outstanding interest
Additional references related to this topic can also be found in the Current World Literature section in this issue (pp. 127–128).
The largest retrospective study of prognosis after first relapse.
The scoring scale derived from retrospective analysis of GOELAM study results.
A retrospective observation emphasizing significant prognostic value of complete remission 1.
Prospective comparison between three different cytarabine-based induction protocols.
Large retrospective series from the Center for International Blood and Marrow Transplant Research.
A review discussing various aspects in choosing the best donor for allogeneic transplantation.
Results of using clofarabine in older patients with relapsed AML.
A prospective randomized study of azacitidine in elderly patients.
A proof of concept study demonstrating that remission can be induced by dendritic cell vaccine.
Description of a therapeutic potential of adoptive T-cell transfer targeting recipient's minor antigen and its side effect in a small series of patients.
A novel approach to improving induction protocol based on immunomodulation with an exact mechanism to be clarified.
A retrospective study of large-scale Eastern Cooperative Oncology Group data demonstrating the value of early (day 14) reinduction.
Important discussion of an appropriate incorporation of MRD monitoring into follow-up standards.
An impressive observation demonstrating the importance of endogenous immune system activity in maintaining remission.
First available data regarding personalized selection of effective therapeutic agents according to specific mutations.
This article has been cited 3 time(s).
allogeneic transplantation; complete remission 2; intensive chemotherapy; minimal residual disease; relapsed/refractory acute myeloid leukemia
© 2012 Lippincott Williams & Wilkins, Inc.
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Based out of beautiful San Luis Obispo, pARTy workshops teach hundreds of students across the Central Coast from Ventura to The Bay! We offer public and private classes in: And More! Wanna join the pARTy? Attend a Scheduled Workshop: Workshops are offered at tasting rooms, restaurants, community centers and more. Check our upcoming events page for an event near you! Or host your own pARTy! For just $35 per person we bring the "pARTy2U!" Includes art materials. 2 Person minimun. Suitable venue required. For inquiries email: email@example.com or call (707) 601-4672. We also offer private tutoring for students looking to futher their artistic skill. _____________________________________________________________ No matter how you join the pARTy no prior art experience is required! Beginners are encouraged! Students are guided every step of the way on how to re-create the featured project. We believe in learning by doing! We always nurture and support individual creativity. Every piece created with pARTy will be 100% the student's own work. You will finish each workshop with your completed project, which is yours to keep and show off! Most students come to pARTy with no prior art experience and leave pleasantly surprised with their creations! Artist/Instructor Skye has a practical, positive and upbeat teaching style, perfect for beginners. More advanced students are welcome to attend any class, and can stray from the featured theme if they wish. Creativity is always welcome! Our mission is to bring the joy of creative expression to people who were too afraid to try before. We want to create a clearly guided, welcoming and supportive creative environment to every single student where they can relax and grow artistically. So what are you waiting for?
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App Description
The little star has always dreamed of flying - but it might be too small to cover a long distance. Luckily the world is full of beautiful hills. Use the hills as jumps - slide down and fly! At least for a moment - until this annoying gravity brings you back down to earth.Procedural generated hills/Particle system(rain, snow ...) will make look different every day you play.
The next hill is waiting for you already, the world is changing every day!
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Mon, May 7, 07 at 2:32
I can't seem to find any information on this shrub. Does it go by another name? I have 3 planted in different spots in the yard for the past 3 years and none will bloom. Any advice?
Thanks, Rise' |
Follow-Up Postings:
- Posted by hoghaven_duluthmn 4 (My Page) on Mon, May 7, 07 at 9:12
This may be "flowering almond". I had a flowering almond when I lived in Zone 3. It would only bloom below the snowline, or after very mild winters. The blossoms were fantastic where it did bloom. However, it would blossom and then there would be a day or 2 of wind, and all blossoms would be "gone with the wind". Since I have moved into a zone 4 area, I did plant a shrub called "flowering plum" last year. It is supposed to be tougher--hopefully I will see some bloom this spring. It is just leafing out now, so perhaps next year. Shrubs usually need at least a year or 2 to settle in before bloom. Moving them around will set them back. Andie |
Mine looks like it is going to bloom well, but I'm surprised since it was sooo cold with basically no snow cover for so long. I resisted getting one for a long time because of the fact that they seemed to only bloom below the snow line, but a couple of mild winters broke my resistance. Now we'll probably be back to harsh winters...lol |
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Microsoft has filed a patent for an "immersive display system" which would project game graphics right into your living room, possibly in 3D, and allow you to interact with them using an enhanced version of Kinect. It's the Holodeck, in short.
The patent, filed 2nd March 2011 and published 6th September, notes that "interactive media experiences, such as video games, are commonly delivered by a high quality, high resolution display.
"Such displays are typically the only source of visual content, so that the media experience is bounded by the bezel of the display. Even when focused on the display, the user may perceive architectural and decorative features of the room the display is in via the user's peripheral vision.
"Such features are typically out of context with respect to the displayed image, muting the entertainment potential of the media experience.
"Further, because some entertainment experiences engage the user's situational awareness (e.g., in experiences like the video game scenario described above), the ability to perceive motion and identify objects in the peripheral environment (i.e., in a region outside of the high resolution display) may intensify the entertainment experience."
The proposed "immersive display system" comprises (deep breath) "a peripheral input configured to receive depth input from a depth camera; a primary display output configured to output a primary image to a primary display device; an environmental display output configured to output a peripheral image to an environmental display; a logic subsystem operatively connectable to the depth camera via the peripheral input, to the primary display via the primary display output, and to the environmental display via the environmental display output; and a data-holding subsystem" which allows the beast to track a user's position, output the aforesaid peripheral image such that it appears to be an extension of the image on-screen.
Elsewhere in the patent, the inventor elaborates that "the peripheral image may include images of scenery and objects that exhibit the same style and context as scenery and objects depicted in the primary image, so that, within an acceptable tolerance, a user focusing on the primary image perceives the primary image and the peripheral image as forming a whole and complete scene.
"In some instances, the same virtual object may be partially displayed as part of the primary image and partially displayed as part of the peripheral image."
The environment display could take the form of "a wide-angle RGB projection display device configured to project a peripheral image in a 360-degree field around the environmental display." Ergo, you'll be able to look at or even interact with things behind the telly.
It might also project in 3D, both the more usual kind where users don active shutter glasses, or the fancy 3DS kind where parallax barriers or lenticular lenses create an autostereoscopic "glassless 3D" effect.
The environment display and depth sensors could be built right into the Kinect unit, which may use eye-tracking to gauge the user's position.
Leaked Xbox 720 design materials from 2010 make mention of just such a combination of 3D, Kinect and environment projection. There's tonnes more through the link. Have a read and let us know what you think.


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This product has been discontinued
Revlon came out with this highlighter, and a larger, all over face powder highlighter, in 3 shades. This is definitely intended for lighter skin tones. It's lovely in the pot, HOWEVER, shows up as a green tint on my NC 30-35 skin. You really have to work at it to get product out of this. Luckily, I didn't pay much, got during WG BOGO. I would skip these and shell out the extra 12-15 bucks for MAC mineralize skin highlighter/finishes. Plus, the MAC pots are much bigger than this.
2 out of 3 people found this review helpful. Did you? Yes No
This is a gorgeous highlighter. Being someone who is not willing to cash out ridiculous prices for MAC's mineralize skinfinish Lightscapade, I figured it wouldn't hurt to try this product - at 8 bucks it's a steal! I tried it for the first time today, and it's gorgeous! Just sweep it above your cheekbone (a little will do) and it will bright a lovely glow to your face. I also like this product because it is not too warm or too cool, it is a nice neutral highlighter for anyone. Very pleased.
1 out of 1 people found this review helpful. Did you? Yes No
A great drugstore highlighter!! I picked up Revlon's 'Pure Confection' at my HEB from a LE display. I really love MAC's Mineralize Skinfinish Highlighters, but I certainly do not like their pricetags. At $5.95, I was able to come to a *very* close dupe of MAC's 'Lightscapade'....'Pure Confection' is a lovely blend of a creamy beige with frosty pink viens. It never looks garish or over the top. I use my cheapie Elf bronzing brush to pick up just the right amount of product and apply it at the top of my cheekbones. I just love the dewy, fresh finish it gives my skin! Rating: 4.5
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More reviews by themisanthrope
This is the first drug store item Ive been excited about in a while.. As soon as I saw it I knew I had to have it - and each Walgreens only has two... So I hid one (the one with the nicest veining) under my register... lol.
Ok, I finally picked it up and I used a flat squareish EOB brush (i don't want to contaminate my only foundation brush for the moment) and used this on my cheeks.. only one cheek - and showed the hubby. He said it brings them out and looks nice(wow a compliment from a guy!)
I agree, if you know how to stroke the brush onto it, you can get different variations of shimmer, color.. etc
I'm very pale and this looks very nice - not warm or cool - I think it can work with most people if they tried different techniques... Like all cosmetics, this should get some practice before dismissing it. This is nice for the price!
I picked this over the other MSF dupes because of the packaging - the packaging of this is much more elegant than the typical, boxy and bulky revlon packages..
I tried this in walgreens today. I am REALLy fair and I noticed that when I rubbed this into my cheeks with my fingers it looked shiny but also left white patches on my face where it was applied. It looked unnatural.
This is so pretty! I never really saw the point of highlighters. I've only used a couple and thought they were meh. But this looked so pretty and it was bogo, so I grabbed one and I'm glad I did! Last night I used a highlighting/skunk brush, and really liked the effect.
2 out of 2 people found this review helpful. Did you? Yes No
I have been looking for a decent highlighter for a while now. Most of the ones I've found have been white/silver based and this one is no exception. On my NW20 skin, the silver highlighters make me look really washed out. I used this under my NARS Orgasm blush and they do look absolutely stunning together. It's very gorgeous in the pan and it does look pretty on but I'd prefer it to be a little more subtle on me which the silver undertone does not allow. I will continue looking for my hg highlighter.
this is my new fav. highlighter. i absolutely love this. some say its a dupe for a msf but i personally have not used msf's so i cant compare. but i use it on the tops of my cheek bones and it looks so gorgeous on.
This caught my eye because it looked like a MAC MSF, especially it looks exactly like Lightscapade, which I do own and love. I decided to just buy it because if it was a Lightscapade dupe then I could swap mine haha...and if it wasent maybe it would give me a different glow that I might like. I love glowy highlighters, WnW AOL being my very very very fav. I dodnt think this could top AOS in the HG department for me and it didnt. It also is not really a accurate dupe for Lightscapade....which is much softer and more subtle...this is more like a failed dupe for Wet N Wild AOS. Its pale gold toned and does give a decent glow /shimmer look. I liked it but I didnt love it. It only duped Lighscapade MSF in the look of the product in the package, not the effect it gives when worn. I'll use mine but I doubt I would by this exact shade again, although I would try others if Revlon came out with them.
When I read on the boards that this product might be a dupe for MAC Lightscapade (a product which I've been lemming for ages) of course I went right out and got it. Now I don't have Lightscapade so I can't compare, but I do have other MSFs including Perfect Topping. Pure Confection is a tad shinier (more metallic) than Perfect Topping, and the shimmer particles are a TAD bigger, but not anything like huge glitter bombs. If you don't like noticeable shimmer particles though, I'd say skip this. Also, the Revlon product seems to have minimal veining, although there were only 3 at the store to compare, but most just have a dollop of pink and light blue veining in a sea of cream color. Needless to say, the payoff of the product is primarily a metallicy cream sheen with shimmer. I got Pure Confection for $8.99 at Walgreens and its .15 oz while MAC MSFs hover around .35 oz for around $27. I like it as a highlighter and would definitely buy again, but this will not end my lust for Lightscapade. Also I think Revlon supposedly has other colors available, but I saw just this on the display case at my store. Give it a try, especially if you lust for MSFs but don't want to spend the money.
4 out of 5 people found this review helpful. Did you? Yes No


text: Our 5-in-1 and 3-in-1 Jackets have a concealed pocket on the back that holds a removable hidden ID panel. We've pre-printed panels with reflective "Police" and "Sheriff" so that you can zip or Velcro® them into the hidden pocket. When you get to a scene where you want greater visibility and identification, all you have to do is unzip the pocket and let the panel drape down your back for identification. Made of durable and supple nylon, these panels go un-noticed in the hidden pocket until you need them. They also add a bit of insulation for cold conditions.


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Delhi to Goa Itinerary
Our Delhi to Goa tour captures the chaos and inspiration of India at its very best. Visit the legendary Taj Mahal in Agra and the incredible sights of Mumbai, Delhi, Goa and more.
- 15
Total price tool tip
- Explorer
- Original
- i
Days 1-2 Delhi
Arrive in Delhi and soak up the sights, sounds and smells of the crowded bazaars and markets of Old Delhi. Perhaps consider an Intrepid Urban Adventure tour to whet the India appetite.
Hotel - 2
Day 3 Agra
Appreciate spectacular views from the Red Fort and be captivated by the timeless architecture of the Taj Mahal. Rise early and see an unforgettable sunrise over this iconic monument, built as an enduring tribute to a lovelorn emperor's late wife.
Hotel - 1
Days 4-5 Jaipur
Be captivated by the intricate pink latticework of the Hawa Mahal, commonly referred to as the 'Palace of the Winds'. Enjoy the quintessential Indian cinema experience at an optional Bollywood movie screening.
Guesthouse - 2
Days 6-7 Pushkar
Mingle with holy men in spiritual Pushkar, and perhaps take a walk to Savitri Temple for sunrise. Pushkar is famed throughout India for its annual camel fair in November.
Hotel - 2
Day 8 Heritage Stay
Get a taste of rural Indian life by visiting a local family, exploring surrounding villages and staying in heritage accommodation.
Heritage Property - 1
Days 9-10 Udaipur
Uncover India's most romantic city, which acts as a hub for artists and musicians. Why not indulge in a bowl of the local speciality at a rooftop restaurant overlooking Lake Pichola.
Hotel - 2
Days 11-12 Mumbai
Pay a visit to the holy Dhobi Ghats, admire the epic Gateway of India, stroll among courting couples on Chowpatty Beach or pick up some tickets to one of the city's famous Bollywood theatres.
Hotel - 1, Overnight sleeper train - 1
Days 13-15 Goa
Farewell the city and head for the sun-kissed beaches, yoga studios and Portuguese influences of Goa. With this enthralling introduction to India complete, perhaps hang around for a few extra days to enjoy the mellow vibe.
Hotel - 2
No trips.
Delhi to Goa Reviews
Our Delhi to Goa trips score an average of 5 out of 5 based on 10 reviews in the last year.
Delhi to Goa, March 2014
Drew Martinez
Perfect way to see India in 2 weeks. There is no way you could cover the same ground and have the amount of experiences on your own in 2 weeks. Our leader Ajay was terrific and provided great local suggestions and advice. The highlight for me was our sunset camel ride in the Pushkar desert!
Review submitted 18 Apr 2014
Delhi to Goa, March 2014
Treena Elliott
This was our first time using Intrepid as well as our first time in India. I didn't know what to expect but was so happy with all aspects of the trip. Pravar is an outstanding tour leader.
Review submitted 02 Apr 2014
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This amazing Millennium Falcon Cake was made by my favorite cake decorator, Mike's Amazing Cakes. The details on the Millennium Falcon's hull is amazing.
If you like this cake, check out some of Mike and his crew's other amazing cakes. Mike's made cakes of Jules Verne, Gilligan's Island, Wizard of Oz, Harley Quinn, Captain Hook, Doc Brown's DeLorean, Portal 2, and Halo. Each cake is a masterpiece.


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Full title reads: "Burry Point. First Atlantic flight by a woman - Sir A. Whitten Brown unveils column raised to commemorate achievement of Miss Amelia Earhart."
Burry Point, Burry Port, Wales.
Sir Arthur Whitten Brown comes forward to unveil a column to commemorate the trans Atlantic flight by Amelia Earhart that landed at Burry Point / Burry Port. A crowd has gathered to see the ceremony and lots of bunting and Union Jack British Flags are hanging up.


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> Vereen is in jail. His brother says he has mental problems and may not have
> been taking his medicine..."
> </>
The same horse - must have been a good date. Mental problems? I
guess so. But I really can't see putting him on a sex offender list
for it. What, the horse complained?


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Updated: February 25, 2013 6:13AM
Here's what Southlanders are accomplishing in college. News includes Homer Glen, Frankfort, Manhattan, Tinley Park, Orland Park, Oak Forest, New Lenox, Midlothian and Lockport.
Trinity Christian College
Several area students graduated from Trinity Christian College in Palos Heights.
Frankfort — Kimberly Wicks, Thomas Tighe
Lockport — Amy Pasik, Alma Farrell
Midlothian — Mark McEvilly
New Lenox — Brittany Host, Robert Ward
Oak Forest — Jeanne Fudacz, Lisa Rackauskas
Orland Park — Jennifer Binkowski, Susan Bratincevic, Rebecca Calhoun, Julie Rolston, Chaz Schutt, David Tadla Jr., Rosa Villanueva, Matthew Muir, Abigail Seyller, Debbie Swider
Tinley Park — Kevin Barron, Joel Kam, Frances Quesada.
Provided to the SouthtownStar


text: Does anyone have a favorite low carb ice cream? I know there's one by Atkins and I think Breyer's put one out. The only one I tried so far because I know they make good lowfat ice cream is Ben & Jerry's Chocolate CarbKarma and it is very good. (I knew I could trust B&J!). I just wish there was a low carb ice cream with some substance like Ben & Jerry's lowfat ones like Cherry Garcia or Chocolate Fudge Brownie although I can see why it would be hard to make this low carb. Has anyone tried any good low carb ice creams? Thanks for your response.


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In God We Vote
Romans 13.1-2 Let everyone be subject to the governing authorities, for there is no authority except that which God has established.The authorities that exist have been established by God. Consequently, whoever rebels against the authority is rebelling against what God has instituted, and those who do so will bring judgment on themselves.
I will be the first to admit that I have an issue with this particular scripture. I have heard many Christians refer to Romans 13 as a call to blindly follow and pray for the leadership that has been elected into office. This is absolutely untrue – it has to be, for we have free will. Should we pray for these godless leaders that are put into office? Yes, we should pray that they are removed.
It is our job as God's people to ensure that godly and morally correct men and women get elected into office. If a godless majority in any society is allowed to have free reign, then we are subject to godless leadership who will serve to destroy everything that we hold dear. Does this mean that God has put these people into office and we should obey them? I already hear the resounding "NO!", and it is at it's loudest today.
Our rights as Christians are being systematically abused and taken away by an increasingly godless society, and it is time to fight for Who's right. We are currently in the most groundbreaking political struggle that has been seen in a very long time. Denominations aside and nominations ahead, it is most clear who is serving God and who is not. I know many Christians who don't even vote, thinking that it does not matter. Could this be one of the reasons why these godless men are being put into office?
As for Romans, there are many biblical scholars who question that Paul even wrote this particular scripture. This is not the venue for that discussion. My point is that it is time to stand up as Christians for the Truth that we believe in and make our voices heard. Get out there and vote today but first, as you enter that little booth of red, white and blue, pray that He gives you guidance and discernment into who the righteous candidate is and that His will truly be done when the day ends.


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Safer cycling near HGV's
HGVs have significant blind spots where cyclist are invisible. Follow the tips below to protect yourself.
- Cycle sensibly and assertively to help yourself stay safe
- Recognise that lorry drivers may not be able to see you
- Never cycle up the left hand side of a lorry stopped at a junction
- Look out for lorries turning left from beside or behind you.
- Don't stop too close to the front of a stopped lorry.
- Take up a visible position at lights: three metres out in front and not by the left kerb or very close to the lorry.
If you wish to find out more you can watch a video clip produced by Transport for London on safer cycling near lorries.
Birmingham City Council and the Freight Transport Association (FTA) are forming a closer working relationship to improve cycling safety through greater driver and cyclist awareness.


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Peggy Louise Bogar, 51, of Ashland, passed away Sunday, May 26, 2013. She was preceded in death by her mother-in-law, Chessie Bogar, and stepfather, Elmer Creech. She is survived by her husband, David W. Bogar; son, Nate Bogar; her mother, Virginia B. Creech; two sisters, Marie Gori and Debbie Stanley, who was a loving caregiver; brother, Allen Davis; and a host of nieces, nephews, family members and close friends. Peggy was employed by Aunt Sarah's Pancake House for 35 years whom she felt were her second family. The family will receive friends Thursday, May 30, 2013, from 6-8:30 p.m. at Nelsen Funeral Home Reid Chapel, 412 S. Washington Highway, Ashland, where services will be held at 2 p.m. Friday, May 31, 2013, with burial at Signal Hill Memorial Park, Hanover, Va.
Alpheus Forrester Holmes, Sr., 85, of Richmond, retired Major in the U.S. military, passed away Saturday, May 25. He is survived by his wife of 21 years, Rowena; and daughter, Paris; and his first wife, Erma B. Holmes; and their five children, Alpheus F. Holmes Jr., Cynthia H. McCoy, Erica V. Holmes, Spencer L. Holmes and Errol S. Holmes; grandchildren and great-grand children. He was a caring husband, father, grandfather, great-grandfather and friend and will be missed by all those whose lives he touched. He served in the U.S. military 21 years. After the military, he graduated in 1970 from Virginia Commonwealth University with BA in education and 1973 from Old Dominion University with MA in English with emphasis in American Literature. He taught English in several universities in Virginia until retirement in 1990. The family received friends Wednesday at the Mechanicsville Chapel of Bennett Funeral Home, Mechanicsville, VA 23111 Graveside services will be private.
James F. Jenkins, Jr., of Richmond, went home to be with God after a lengthy illness May 19, 2013. He is survived by his wife, Lorene P. Jenkins, the love of his life; his wonderful son, Steve and his wife, Jean; and his grandchildren, Bryan and his wife, Stefanie, and Kristen and her husband, Camaron Ballard. In his earlier years, he was in a small country music band. He then was employed by Richmond Engineering Company for 37 years as Vice President. His next job was with CSX Corporation. Mr. Jenkins was a member of Northside Baptist Church for 57 years, where he taught Sunday School for many years. The family would like to thank his family and friends for all the love that was shown during his illness. The family received friends Wednesday, May 22, at the Mechanicsville Chapel of the Bennett Funeral Home, where services were held Thursday, May 23. Interment followed in Forest Lawn Cemetery. As an alternative to flowers, please consider a donation to Northside Baptist Church, 7600 Studley Road, Mechanicsville, VA 23116, or At Home Care, 4110 Fitzhugh Avenue, Richmond, VA 23230.
Mary Ziyacz Jones, 99, of Ashland, passed away Saturday, May 25, 2013. She was the widow of Thomas W. Jones, Jr. Born Oct. 19, 1913; she was five months shy of observing her 100th birthday. Mary was born in Youngstown, Ohio but her family moved to Claremont, Va. when she was a young girl. She was the daughter of the late Julia and Nicholas Ziyacz and was preceded in death by her younger siblings; Helen Ziyacz, Julia Z. Kovach and George Ziyacz. She is survived by her daughter, Juanita Jones, of Ashland; her daughter and son-in-law, Julia J. and Bruce Booker of Richmond; and her grandchildren, Kathryn Booker of Richmond and John Booker of Boston, Massachusetts. She is also survived by her sister-in-law, Jeanne J. Repine of Fayetteville, Ga., and a number of other relatives, including her niece, Helen K. Bachochin of Hellertown, Pa. and nephew, Joe Kovach of Bethlehem, Pa. She is also survived by many friends. Before her marriage she had several jobs, one of which was as a control operator at Richmond radio station WRVA, during the WWII war years and after. After her marriage, she devoted herself to family and home. She was also active in several local groups, including long time membership in Henry Clay Homemaker's Club and the Mt. Olivet Church's Young at Heart Club. Mary loved the Lord and her family and had a remarkable zest for life and learning. She was an inspiration to many and the world is a better place because she was here. The family received friends Wednesday, May 29, 2013, at the Nelsen Funeral Home Reid Chapel, 412 S. Washington Highway, Ashland, where funeral services were held Thursday, May 30, 2013, with burial in Signal Hill Memorial Park, Hanover, Va.
Calvin Mills, 82, of Ashland, went to be with his Lord Friday, May 24, 2013. He was preceded in death by two sons, Buddy and David Mills. He left behind his wife of 62 years, Nell Mills; one son, Mickey Mills; one daughter, Theresa Watson; 15 grandchildren; seven great-grandchildren; two brothers, Gene and Albert Mills; and one sister, Becky Miller. He was a member of New Found Church of Christ. He was a retired painting contractor. Memorial services were held at New Found Church of Christ at 3 p.m. Sunday, June 2, 2013.
Ann Downer Reid, 80, of Richmond, departed this life May 20, 2013. She was preceded in death by her husband, John Clifton Reid. She was the daughter of Mary Jeter and Grover Cleveland Downer; and is survived by her children, Karen Cridlin and her husband, Danny, of Mechanicsville, Gretchen Brown and her husband, Robert, of Fairfax, Ashley Kaufelt and her husband, Chris, of Mechanicsville, and Kevin Reid and his wife, Kathy, of Cape Charles. She leaves a legacy of eight grandchildren, Michael and Andrew Cridlin, Autumn and Tyler Brown, Bryce and Olivia Ann Reid, Lauren and Christopher Kaufelt; and a great-granddaughter, Lily Cridlin. The family received friends Wednesday, May 22, at the Mechanicsville Chapel of the Bennett Funeral Home. Graveside services were held Thursday, May 23, at Riverview Cemetery. In lieu of flowers, please consider a contribution to the Epilepsy Foundation, or a charity of your choice.
David William (Bill) Rhyne, 63, of Doswell, lost his courageous battle with cancer May 23, 2013, peacefully with his family by his side. Bill was born June 4, 1949 in Richmond to Sloan Alexander (S.A.) and Jane Johnston Rhyne. He graduated from the United States Military Academy at West Point and received his Master's Degree in Geography from Penn State. He proudly served in the Army for 22 years and retired as a Lieutenant Colonel. He then worked for 12 years as a middle school educator in Earth Science with Hanover County. He ended his professional career as a Coordinator with the Math and Science Innovation Center. His wonderfully patient and loving nature, beautiful smile, wicked sense of humor and positive outlook on life drew people to him wherever he went. He is survived by his wife of 41 years, Janice; daughters, Kimberly and Elizabeth, whom he was so proud; grandchildren, Kaya and Jayden, who brought him so much joy; his mother Jane and eleven siblings along with their families, who gave him constant support and love. He will be missed by so many. A memorial service will be held at Storke Funeral Home, Bowling Green, Friday, May 31 at 7 p.m. In lieu of flowers, the family requests a donation be made to the Wounded Warrior Project or the American Cancer Society.
Lila Theresa Hatfield Sipple, 79, of Ruther Glen, departed this life Friday, May 24, 2013. Born May 1, 1934 in Matewan, W. Va., She was preceded in death by her husband, Clifford Sipple. She is survived by her son, David Sipple and wife, Kimberly; grandchildren, Amy Kroll, Amber Whiting and Abby Heppert; and three great-great-grandchildren. The family received friends Sunday, May 26, at the Mechanicsville Chapel of Bennett Funeral Home. Services were held Thursday, May 30, 2013 at Quantico National Cemetery, Triangle, Va. The family would like to thank the caring staff at VCU/ Massey Cancer Center for their love and kindness.
Irene N. Smith, 85, of Mechanicsville, went to be with the Lord Tuesday, May 21, 2013. She was preceded in death by her husband, George Smith, Sr.; and a son, Sammy Smith; and is survived by her son, Mac Smith and his wife, Faye; four grandchildren, G.M. Smith, III, Crystal Leech, Jaime Brookman and Alan Brookman; five great-grandchildren, Madison, Kaden, Micah, Sierra and special great-granddaughter, Kaleigh; brother, Earl Nuckols; as well as a host of nieces and nephews. The family received friends Wednesday at the Mechanicsville Chapel of the Bennett Funeral Home, where services were held Thursday, May 23, 2013. Interment Forest Lawn Cemetery.
Bernard E. Sprouse, Sr., 80, of Henrico, went to be with his Lord Tuesday, May 21, 2013. He is survived by his loving wife of 35 years, Nancy; two daughters, Linda and Joyce; five sons, Bernard Jr., Carlton, Gary, Charles "Chuck" and Chris; 16 grands and 10 great-grands; one sister, June; and two brothers, Charlie and Eugene. He was a member of the Washington Henry Masonic Lode #344, ACCA Shrine, ACCA Provost Guard and the Ashland Moose Lodge. He worked for the Ashland Police Department, where he served as Chief, and the Ashland Volunteer Fire Department. The family received friends Friday, May 24, with a Masonic Service at the Mechanicsville Chapel of the Bennett Funeral Home, Mechanicsville.


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We are feverishly planning and counting down to the WDW Radio Cruise 2.0!
Lots of exciting things in the works, so stay tuned!
A number of people have asked about going solo, or are thinking of going but looking for someone to share a room with. Is that you? Are you interested in joining us (and Richard Sherman!) on the cruise and want to share a cabin?
Post here or email me at email@example.com
Hope to see you there!


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StatusThe thesis was presented on the 4 December, 2012Approved by NCAA on the 20 December, 2012 Abstract– 0.95 Mb / in romanian– 0.78 Mb / in russian |
Dissertation structure: the introduction, three chapters, general conclusions and recommendations, the bibliography (177 sources), 137 pages of the basic text, 34 drawings, 77 tables and 29 appendices.
The purpose and dissertation tasks сonsists in development and application of model of optimisation of the finance wine industry enterprises. by means of application of financial instruments, that is it is necessary: to interpret concept «optimization of the financial management enterprise»; to develop model of optimisation of financial management enterprise; to conduct financial analysis of the wine industry enterprises by existing techniques; to make the analysis of use of financial instruments; to adapt use of a matrix of financial strategy for optimization of the financial management enterprise of Republic Moldova; to offer a technique of determination of optimum value of the sum of the credit agreement as one of the basic financial instruments of enhancement of strategy of financing of investment projects; to develop and practically to apply model of cost determination of assets at the conclusion of the lease agreement to optimization of the financial management enterprise.
Scientific novelty and originality of research consists in: specification of concept of optimization of the financial management enterprise; developments of model of optimisation of management by the enterprise finance; adaptations of a graphical method of the financial analysis for an estimation of an economic-financial situation of enterprises RM; application of a matrix of the financial strategy adapted for conditions of RM, for a choice of optimum strategy of development; uses of hybrid financial instruments for minimisation of financial risks; enhancement of elements of the credit agreement; developments of model of cost determination of assets at the conclusion of the lease agreement for optimization of the financial management enterprise.
The decision of a scientific problem in studied area consists in enhancement of management by the finance of the wine industry enterprises of Republic Moldova by application necessary primary and derivative financial instruments. Research has shown that events offered by us will allow: to optimise calculation of the sum of the credit agreement that, finally, will allow to receive economy at a rate of 3 % from the received sum of borrowed funds. The theoretical importance of research consists that the concept of optimisation of management developed in the dissertation the enterprise finance develops the theory of management of the finance enterprise.
Introduction of scientific results: models and some recommendations developed in given work, have been accepted for use at the several enterprises of Republic Moldova that confirms by adoption deeds of results of the research enclosed to the dissertation.
Under consideration [4] :
Theses Archive:


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MOVIES Tom Hanks, in cahoots with the mujahideen! His company just bought the rights to the new book Charlie Wilson's War, and he wants to play the real-life Texas congressman who worked with the CIA to train Afghan freedom fighters in the struggle against the Soviet Union.... Taxi! Jimmy Fallon will play a detective and Queen Latifah the cabbie who chauffeurs him round town, while Barbershop boss Tim Story directs this remake of a French comedy.... Adam Sandler's Happy Madison will produce a remake of Burt Reynolds' 1974 The Longest Yard; alas, Sandler isn't planning on playing the convict captain of a prison football team.... Vince Vaughn -- last seen admirably holding his own against Will Ferrell in Old School -- has joined Keanu Reeves, Tilda Swinton, and Vincent D'Onofrio in Thumbsucker, about a kid who can't stop sucking his thumb.... Jamie Kennedy is attached to star in The Afterparty, a comedy about a guy who gets so wasted at his bachelor party that a movie's worth of complications ensue.... Abandon Pictures reportedly plans to turn the comic strip Hagar the Horrible into a live-action feature; now option Beetle Bailey and Funky Winkerbean and let's have us a trilogy!
TELEVISION James Brolin is Ronald to Judy Davis' Nancy in CBS' four-hour The Reagans.... Crazy old guys on the loose! Comics legend Stan Lee and Playboy guru Hugh Hefner are teaming up for -- honest to goodness -- Hef's Superbunnies, a cartoon series about a hot team of Playmates who, led by Hef, fight bad guys.... Finally, in a deal that bodes well for the apocalypse, Rosanna Arquette (Having Babies II) is working with ABC Family on a sitcom loosely based on her life. We recommend Nicolas Cage for the role of the sulking movie-star ex-brother-in-law. Gregory Kirschling


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Large chunks of ice from Lake Erie pile up at the end of the Portage River.
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Look beyond soluble and insoluble fiber to resistant fiber. Proven by studies to aid with weight loss, resistant fiber can aid in weight control more so than any other type of fiber.
What is Resistant Fiber
Sources of Resistant Fiber
Adapted from Today's Dietitan magazine, sept 2012
follow me on instagram at @nutritionvault and check back for more health and nutrition tips :)
What is Resistant Fiber
- Resistant fiber helps keep you fuller for longer, increase your metabolism, and helps you consume less calories
- Resistant fiber has the highest satiety effect compared to all others fiber which helps with weight control.
- Resistant fiber is a type of fiber that is not digested in the small intestine, and is later digested by bacteria in the colon. For that reason, that piece of food yields less calories because the small intestine cannot break it down to get calories.
- The average american has about 4 grams of resistant fiber per day - NOT ENOUGH
- Aim for 15 to 20 grams of resistant fiber per day to get the maximum benefits
Sources of Resistant Fiber
- Natural sources
- Unripe banana
- Rolled oats
- Lentils
- White beans
- Pearl Barley
- Seek out pastas, flours, breads with added hi-maize starch (look on the ingridient list for cornstarch, corn bran, resistant corn starch)
- Hi-Maize corn starch - can be used as a supplement to increase the intake of resistant starch. It can be added to baked goods, flour replacement, sprinkled on top of oatmeal, smoothies, and added to sauces and casseroles.
Adapted from Today's Dietitan magazine, sept 2012
follow me on instagram at @nutritionvault and check back for more health and nutrition tips :)


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"Really Great. Nice and crisp with just the right amount of garlic and dill. I used seedless cucumbers qne the worked just fine."
"This was no doubt a wonderful fantastic recipe. We used fresh hanover tomatoes and fresh basil from our garden, our guest raved about it. I can not wait to make this again. Make you use frest tomatoes and fresh basil. This recipe is a guaranteed winner. Treat yourself and family and friends."
"This is a stone cold winner. Super easy and pretty.we followed the recipe down to the last word. we did put the watermelon in a colander to drain before putting everything together. Love the moderate heat from the peppers. This will be a summer regular. Thanks for the recipe"
"Sooooo Easy and so very good. we make smoothies all the time and this ranks high on the list. we will make it again an again. Thanks for the recipe"
"This was outstanding. The Jack Daniels flavor was just right. I followed the recipe in every way except I used Splenda. The recipe was a little hard for me to follow. For instance, where and when do you put the raisins? The exact order of things was confusing. STILL This is a clear 5 star keeper."
"Wow....Bursting with flavor. The veggies were fantastic and it was easy to make.. This dish will show up on our table on a regular basis..Thanks for this recipe. Made for Spring PAC 2014"
"Very good. The flavors blend nicely ane the smell is wonderful.. Prep time is more than stated, maybe an extra 10 minutes. Next time I will cut the orange marmalade by 1/3 an use only a couple teaspoons of sugar..Other than I will do this again soon."
"Even though there seems to be a lot of choping this is not a hard recipe. Fresh ingredients make it worth it. The only change I made was the use of a hand blendder to make it a smooth soup. I likedthe results and recommend you try it. I had way to much roux and frooze the left over .It last in the freezer about 30 to 60 days."
"Disappointing ,,,The recipe did not describe what size loaf pan to use. So I used a regular loaf pan. I cooked it 45 minutes which is to long. It turned out tasty but dry. The loaf came out about 2 inches high. I used ripe fresh persimmons. Opened for the first time spices; I think the chef should add what size pans to use. I did use splenda.I wou..."


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Friday, November 11, 2005 - Page updated at 12:00 AM Book Reviews Caravaggio: From shadows into lightSpecial to The Seattle Times
"The Lost Painting: The Quest for a Caravaggio Masterpiece" "Caravaggio: Painter of Miracles" Garage-sale mavens with an eye for art have often thrilled to the tantalizing thought. What if that dusty old painting leaning against the back wall that looks a little like a Picasso, really is, well, a Picasso? Weirder things happen. And "lost" paintings by famous painters are occasionally found tucked away in attics or hung in plain sight of people who lack the art sophistication to know what they've got. If you're an art historian or an art conservator, however, "discovering" a lost painting is the Holy Grail. If an art professional is fortunate enough or smart enough to find a painting that was once known to exist but is now "lost" — meaning that art historians do not (now) know who owns it or where it is — the discovery can change the course of the discoverer's career. Jonathan Harr's fast-paced new nonfiction work, "The Lost Painting: The Quest for a Caravaggio Masterpiece," is such a tale. Written as an art-world page turner, the book describes how a couple of plucky Rome-based Italian graduate students and an Italian art conservator working in Dublin, Ireland, trace the whereabouts of "The Taking of Christ," a painting by Michelangelo Merisi da Caravaggio (1571-1610), the astonishingly gifted artist known simply as Caravaggio. Though records kept by Caravaggio's 17h-century patrons indicated that "The Taking of Christ" was painted, the painting had been "lost" for several hundred years. Coming up Jonathan Harr, author of "The Lost Painting," will read at 7 p.m. Monday at Third Place Books in Lake Forest Park (206-366-3333; www.thirdplacebooks.com). He will read at 7 p.m. Tuesday at Seattle's University Book Store (206-634-3400; www.ubookstore.com). The detective story starts in 1989, when the graduate students begin researching archives as part of a project to distinguish once and for all which of two versions of a famous Caravaggio called "St. John" is real and which is the copy. As they delve into archives located in remote parts of Italy, however, the students find references to "The Taking of Christ," a painting believed to show the dramatic moment when Judas kisses Jesus, betraying him to the Romans who will crucify him. One of the students, Francesca Cappelletti, is especially dogged. In the next few years her research takes her to archives, museums and auction houses in London, Rome and Edinburgh, in her effort to solve the mystery of the lost painting. Other characters include Sir Denis Mahon, a dignified 85-year-old English art historian who is the world's leading Caravaggio scholar, and Sergio Benedetti, an Italian art conservator who feels marooned in the art-world backwater of Dublin. But when Benedetti makes a courtesy call to a Jesuit monastery that wants a few of its dusty old paintings polished up, the story takes an exciting twist. Harr, who has written for The New Yorker and The New York Times Magazine, is a nonfiction writer of note, having won the National Book Critics Award for Nonfiction for "A Civil Action," a case study of the U.S. legal system. And in this book he uses his skills in literary journalism to outline Caravaggio's difficult and short life, while also shining a light on the arcane world of academic art history and restoration. Readers will learn, for example, that to reline an old painting with new canvas includes cooking up a pot of glue made of white vinegar, molasses and purified ox bile. As with all literary journalism, skeptics may justifiably wonder how Harr has re-created the exact dialogue of meetings to which he was not privy, and this reader found discussions of Cappelletti's romantic life little more than speed bumps in an otherwise brisk narrative. Still, for anyone who is remotely interested in art and art history, Harr's account of the lost Caravaggio is engaging. And if you haven't read the several much larger biographies of Caravaggio published in recent years, Francine Prose's "Caravaggio: Painter of Miracles," is a worthy alternative. One of the slim volumes in Harper Collins' Eminent Lives series, it is tautly written and insightful. Known for her fine essays and fiction, Prose also frequently writes art criticism for The Wall Street Journal. Copyright © 2005 The Seattle Times Company |


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Many assaults, batteries in October
Police reports show a number of assaults have been reported on campus and in Carbondale over the past 10 days.
Carbondale Police
Police arrested a Tennessee man after they received a report of shots fired near the 800 block of East Grand Avenue around ... Continue Reading →
Students robbed, battered on campus
The SIU Department of Public Safety is investigating a battery and robbery that occurred Tuesday on the south end of Anthony Hall.
The incident happened at 11:40 p.m. and involved a 20-year-old student, according to the DPS website. The student told police ... Continue Reading →


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We are in need of help designing the layout of our master bathroom in our new home. I have attached a copy of the layout our designer provided, for the sake of time we accepted the layout knowing that we would change it prior to construction of the home. I appreciate any comments: |
Image link: Need Help Designing Layout of Master Bath (32 k)
Follow-Up Postings:
- Posted by elizawhyza (My Page) on Thu, Sep 15, 11 at 6:01
My comment has nothing to do with layout per se, but would you consider not making a separate compartment for the toilet? I have never seen one I liked. :-) Actually, I feel like I've been sent to "time out" or something. The compartments always seem too small, and at least for me, my husband and I are not using the bath at the same time often enough for it to be an issue of privacy, if that is the concern. Knee walls work just as well, imho. I will look at the layout, too. Do you have any immediate likes or dislikes about it? |
- Posted by maggiepie11 (My Page) on Wed, Aug 22, 12 at 13:18
hi there. overall it looks like it will be a beautiful bathroom! i agree with the previous poster that toilet compartments aren't for us. we have a kneewall and it works just fine for us but to each his own. :) there are 2 other comments i'd make. 1) we have a giant walk-in shower with a bench that's all done in tile (floor, walls, bench, and ceiling) and it's ridiculously hard to keep it clean. it needs to be re-caulked every 6 months or so (as ours is on an exterior wall in a cold winter climate - i see yours is interior so no problem there), and i always feel cold despite 2 shower heads covering me with water. the warmth of the shower isn't contained because the space is so large. if you've had a big shower like this before and like it, just ignore these comments. :) 2) one thing i really miss in our master bath is a nice place to sit and primp. i have a large walk-in closet as well, and put a seat, little shelf, and mirror in there, but the lighting is terrible with no natural light. you have so much space that i'd suggest a place for a low vanity for sitting and styling hair and putting on makeup. (or standing and putting on makeup). maybe there's a nugget of something helpful in these ramblings? good luck! |
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For those of you that had the chance to read our review on the Kingston DT4000, today we take things one step further increasing FIPS 140-2 to Level 3 maintaining hardware based 256-bit encryption in the same compact USB flash drive form factor. The Kingston DT6000 may seem like a standard flash drive on the outside. Looking internally though, the flash drive combines years of intense research and development from Spyrus in security technology. Featuring Level 3 military grade FIPS 140-2 compliance, the DT6000 ensures your sensitive data will never be compromised. Compatibility extends to all modern Windows operating systems, along with Mac OS X 10.6+ Warranty is listed at five years. The DT6000 features the same rugged exterior design we found with the DT4000. Branding and capacity are listed on the front of the drive. The back of the drive houses the model identification and assembly information, along with the Spyrus logo. The Kingston DT6000 utilizes a capped design, which allows for the drive to be waterproof up to four feet. Setting up the DT6000, we first select our preferred language. Like the DT4000, the Kingston DT6000 allows 10 attempts at entering the correct password, before the drive is erased. | Going back into the settings. Here you can change your password, along with the password hint. The Kingston DT4000 is factory formatted with the FAT32 file system, insuring compatibility between Windows and Macintosh computers. The usable capacity after formatting is 29.6GB. For a quick performance check, we ran through CDM with the DT6000. Here we have 22 MB/s for sequential read and 12 MB/s for write. The Kingston DT6000 furthers the amount of security features we found in the DT4000 by quite a bit. Here we have the same 256-bit hardware encryption we found in the DT4000, but by partnering with Spyrus, the DT6000 sector-based USB encryption device implements Suite B high-strength cryptographic algorithms and advanced key management. In addition to this, the DT6000 does not store the PIN internally. Instead, the PIN is entered over a secure channel and is mathematically combined with other information using Suite B algorithms to generate a Master Encryption Key. Performance of the DT6000 met up with our expectations, being a secured flash drive never did the term performance cross our minds, and we knew this going in. However, the drive was able to accomplish 22 MB/s read and 12 MB/s write, which is rather decent performance for a USB 2.0 secured solution. Pricing for the 32GB Kingston DT6000 is set at $229.99 and can be found at many e-tailers and accordingly Kingston's online store. |
Kingston DataTraveler 6000 FIPS Level 3 Encrypted Flash Drive Review
In the market for military grade encrypted storage? Read on as we take a look at the Kingston DT6000 and see exactly what it has to offer.
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TweakTown Rating: 90%Manufacturer: Kingston
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text: Dragon Tiger Gate () is a martial arts academy established by two powerful martial artists to stand up for justice and protect the city citizens from the triad gangs. The school also acts as a haven for children who have become orphaned as a result of gang activities. Wong Fu Hu, one of the founders of the academy, has two sons, Dragon and Tiger, each with a different mother. When the boys are still small, Dragon's mother chooses to leave the Gate, and gives Dragon half of a jade amulet pendant, telling him that Tiger has the other half. When Dragon's mother is killed in a fire, Dragon is taken under the wing of Ma Qwun, a triad boss for a rival martial arts gang called Luosha Gate. Dragon grows up and becomes Ma Qwun's personal bodyguard. Years later, Tiger and his friends are dining at a restaurant on the same day that Ma Qwun is receiving the Luosha plaque. The plaque is a symbol that shows that he is the top triad boss in the Luosha Gate, second only to its leader, Shibumi. Ma Qwun and the leader of The White Lions gang are arguing over the Louosha plaque when Tiger stars a fight with three gang members. Tiger throws the boss into the ceiling and the impact causes the ceiling to break and the Luosha plaque to fall through. One of Tiger's friends takes the plaque. Ma Qwun's underlings attack Tiger, who is able to fend them off easily. Then Dragon arrives and fights off Tiger; both brothers don't recognise each other. Ma Qwun calls the fight off. Later that night, Tiger and his friends eat at a Japanese restaurant, and Dragon comes to take the plaque back. Tiger and his companions collapse as a result of having been drugged by Scaly, Ma Qwun's assistant, who also wants to get the plaque in order to show-up Dragon and become Ma Qwun's favourite. Scaly orders his minions to attack Dragon, who fights them off. Turbo, a fighter who had also been enjoying his dinner in the restaurant, is brought into the fight and helps Dragon defeat the hoard. The fight ends and Dragon leaves with the Luosha plaque. Tiger finds Dragon's half of the jade pendant that had been dropped in the fight, and realizes their connection. Turbo follows Tiger to Dragon Tiger Gate, where he tries to enrol to better his martial arts, but is kicked out by Master Wong Jiang Long, the current leader of the Gate. Turbo camps out at the school, promising not to leave until Master Wong agrees to teach him. Master Wong agrees to spar with him, and Turbo is soundly defeated. Turbo is humbled, and allowed in as a student. Ma Qwun returns the Luosha plaque in hopes of retiring, much to the approval of Dragon and his daughter, Xiaoling. Xiaoling wants for a simpler life, while Dragon hopes to return to the Dragon Tiger Gate. Seeing this as an insult, Shibumi sends his lead henchmen, the Double Devils to kill Ma Qwun. He uses his subordinate Rosa to lure Dragon away as the hit is performed. Dragon arrives too late to save Ma Qwun, but defeats the Double Devils. He leaves Xiaoling in Tiger's care and leaves to mourn Ma Qwun. Shibumi is impressed by the defeat of the Double Devils and goes to Dragon Tiger Gate to set a challenge. The challenge is accepted by Turbo, Master Wong, and then Tiger. Master Wong is killed, while Turbo and Tiger and seriously injured. Xiaoling takes Turbo and Tiger to Mount Bai Yun for Master Qi's help in healing. He heals the two martial artists and teaches each of them a new technique to use in their inevitable fight with Shibumi. Tiger and Turbo go to Shibumi's Black Pagoda to stop his evil doings once and for all. Though they both have greatly improved, Shibumi fends them off until Dragon arrives to kill Shibumi himself. Dragon lures him into close-quarters combat and unleashes his technique, the Eighteen Dragon-Slaying Palms. In the end Dragon defeats Shibumi. Shibumi is still alive and runs away. Dragon then returns to Dragon Tiger Gate with Tiger and Turbo at his side.


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United Weavers Marshfield Master of the Meadow Natural Rug
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A series of blood drives at locations in Mesa, Gilbert, Chandler and Tempe are scheduled beginning Nov. 1, with a particular need to collect O-negative blood.
The drives, which end on Nov. 30, the drives will help United Blood Services' keep a sufficient supply of blood — the shelf life for a donation is 42 days — throughout the Thanksgiving holiday and beyond. Outside of the East Valley, United Blood Service will collect blood at locations in the greater Phoenix metro area.
For a full list of locations, dates and times for every municipality, visit bloodhero.com or call (877) 827-4376.


text:
Summary: Essentials of Health Care Finance stands firmly in its place as the leading textbook on healthcare finance. No other text so completely blends the best of current finance theory with the tools needed in day-to-day practice. Useful for all course levels as well as a professional reference, this text offers a comprehensive introduction to the field. The Seventh Edition has been thoroughly revised to reflect the current economic environment in the healthcare industry, with thoughtful de ...show morescriptions and real-world' examples. As the not-for-profit health care sector has increasingly come under attack by legislators seeking new sources of tax revenue, this edition also features a new chapter on assessing community benefits including an examination of the new Schedule H of the IRS 990 form.Ancillary instructor materials for the Seventh Edition have been significantly expanded and updated. PowerPoint lecture slides now include selected examples from the chapters. Electronic versions of many of the charts and tables in the chapters are provided to enable the instructor to re-create and modify existing examples. An expanded set of test questions with detailed answers will be provided for each chapter. New excel spreadsheets for selected chapters will be created to help both the students and the instructors perform a variety of financial analysis tasks with spreadsheet templates. The instructor's manual has been revised to include key learning points, chapter overviews, and guidelines for class discussion. ...show less
Edition/Copyright: 7TH 1118 more offers below.
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The New Year typically brings declarations to eat healthy, and we know that can be hard sometimes. But eating healthy doesn't have to be tasteless and boring – here are just a few of our favorite products for keeping that "be healthy" resolution. Want more information or recommendations? Just talk with one of our wellness consultants – they're happy to share their favorites with you!
Way Better Sprouted Snacks You don't have to give up your favorite salty snacks with Way Better Snacks. These tortilla chips are made with sprouted ingredients like organic sprouted quinoa, organic sprouted brown rice flour, sprouted black beans and broccoli and more. Sprouting has many benefits, including increased vitamins and minerals, increased antioxidants, increased digestibility and increased nutrient absorption.
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I Heart Keenwah Quinoa mixed with other natural ingredients like organic chocolate, almond oil and honey, these tasty little clusters are a sweet treat that makes a fulfilling and delicious snack. Quinoa contains all nine essential amino acids and is the only whole grain that's a complete source of protein. Try this to satisfy you sweet tooth without feeling guilty.
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This is a syndicated post from The American Catholic. [Read the original article...]
Click here to view the embedded video.
I agree with the President. So long as he is President nothing will change from the disaster he served up in his first term. More of the Same is the real Obama campaign slogan.
Click here to view the embedded video.


text:
High Schools in San Jose
Middle College High School Public • Grades 11-12
40 students • 20 student/teacher -
Lynbrook High School Public • Grades 9-12
1837 students • 21 student/teacher -
Leland High School Public • Grades 9-12
1845 students • 23 student/teacher -
University Preparatory Academy Charter Charter • Grades 7-11
324 students • 17 student/teacher -
Evergreen Valley High School Public • Grades 9-12
2737 students • 23 student/teacher -
Pioneer High School Public • Grades 9-12
1595 students • 21 student/teacher
Which schools are assigned to my home?
About San Jose
San Jose contains 58 schools. One of the best schools is Middle College High School, which has a rating of 10. The school has 40 children. The public schools in San Jose are in San Jose Unified School District or East Side Union High. Franklin-Mckinley Elementary School District is close and is rated worse than San Jose Unified School District. Nearby Mt. Pleasant Elementary scores lower, with a rating of 4.
School Districts Near San Jose
Disclaimer: School attendance zone boundaries are supplied by Maponics and are subject to change. Check with the applicable school district prior to making a decision based on these boundaries.


text: Find this wine Find this wine Papillon Wine 2009. Very good. And ver my big. Orin Swift. Pin It Tweet one year ago by Chris S. More posts Papillon Napa Valley Red Wine 2011 Plum, burnt rubber and BBQ meats. Rich body, heady but not overly so. Warm, pleasant tannins with a light fruit finish. 10 months ago by Joseph G. Napa Valley Papillon Red Wine 2010 92 pts One red door Hudson 60% cab, 37% merlot, petit Verdot , Malbec one year ago by cherjones Papillon Wine 175 cost. one year ago by Bryan T. Papillon Wine Papillon 2 years ago by Ryan J. Papill Papillon from Orin Swift. Gray wine. Let breath. 4 of 4. One of my favorites. 3 years ago by Kethomas


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Straddle Strangle Swaps
Fri, May 23, 2008 | Jared Woodard
To the right is a fun little trade called the Straddle Strangle Swap. Look familiar? It looks a lot like a simple calendar spread or a butterfly spread. In actuality it is both, making it what I consider a sort of super calendar spread. Now lets take a look at how to construct these and what qualities make them so super.
Straddle Strangle Swaps are a specific type of Double Diagonal. They involve selling a front month straddle and buying a back month strangle. In our WAG trade pictured we sold the June 35 strike put and call and bought the July 40 call and 30 put. As you can see it provides positive Theta, and in this case negative Vega. (Using a longer calendar spread such as June/Sept would provide positive Vega). Straddle Strangle swaps are typically delta neutral but this will depend on the strike of the straddle. Like a calendar spread it will have negative delta as the market heads above the strike and will have positive delta when the market heads below the strike. So with all these similarities to calendar spreads what makes it so super?
Looking at the June/July 35 Calendar (image to the lower right) you can see that it is not as wide as the swap. Its break even points are 33.95 and 36.16 vs 33.20 and 36.72. This gives the Straddle Strangle Swap a 1.31 of additional width. (Using a longer dated calendar spread such as Oct/June would widen the calendar significantly but would still not be as wide as the swap). The calendar has positive Vega but has only half the Theta of the swap.
Another good thing about the Straddle Strangle Swap trade is that it is executed for a credit rather than a debit. This allows you to earn interest on the credit plus the buying power it utilizes. With today's low interest rates it doesn't amount to much. However, if you use margin in your account this can be a good way to save a lot of money from margin costs since you will be using your own cash rather than your brokers.
Last but not least one should take note of commissions implications. If you pay commission on a per-contract basis the swap is significantly cheaper, requiring only 4 contracts. The calendar requires 12 contracts to utilize equivalent buying power which means about 3x the commissions. However, if you are charged by the number of legs in the trade, like many brokers do, the calendar spread option is half the cost of the swap. Of course you should never let the commission tail wag the dog but the commissions implications are certainly worth paying attention to. All other things being equal, commissions may be the margin upon which you choose one over the other.
Stay tuned for more on Double Diagonals such as the Straddle Strangle Swap.
Tags: calendar, double digaonal, straddle, strangle, swap, wag