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On December 11, Lyric Opera of Chicago creative consultant Renée Fleming joined Chicago Symphony Orchestra creative consultant Yo-Yo Ma at a key event supporting arts education in the Chicago Public Schools.
To an audience of CPS principals, network chiefs, teachers, and students, Mayor Rahm Emanuel and CPS CEO Barbara Byrd-Bennett announced that 45 schools would be receiving funding for art learning opportunities. These awards are the inaugural grants from the newly created Creative Schools Fund, which is part of the CPS Arts Education Plan.
Among the 45 grantees are seven schools that have participated in Lyric Unlimited's educational programs this season: Charles R. Darwin Elementary School, George Armstrong International Studies Elementary School, Henry Clay Elementary School, Hiram H. Belding Elementary School, Jordan Elementary Community School, Kenwood Academy High School, and Lionel Hampton Fine & Performing Arts Elementary School.
After remarks from Lyric Opera general director Anthony Freud and the announcement from the mayor, Renée spoke passionately about the transformative power of arts in schools. The daughter of two public school music teachers, she described being a shy teenager who found her voice and a way of expressing herself through music and poetry.
The event featured performances from student groups, including a choir from Gallery 37, an afterschool choral program for CPS students that is also one of five participants in Lyric's Vocal Partnership Program. This expanded program, part of Lyric Unlimited, gives students the opportunity to learn about opera and develop their skills through special events such as Lyric Opera performances and rehearsals, backstage tours, and master classes and conversations with main stage artists.
Kiela Nelson, a member of the Gallery 37 choir, is also part of Lyric's new Youth Opera Council. She and her fellow singers met and mingled with Renée Fleming after the event.
Renée and Yo-Yo also performed a delightful rendition of "Winter Wonderland," a nod to the arctic temperatures in Chicago and across the nation.
Lyric and the CSO are the lead arts partners for the CPS Arts Education Plan. As part of that collaboration, Fleming and Ma have been named National Cultural Advisors, providing guidance to CPS and the Mayor's Office and raising awareness of the importance of the arts for every child in every classroom.
Both artists were present in October 2012 when Mayor Emanuel first announced the CPS Arts Education Plan at Perez Elementary School. And earlier that year, Renée and Yo-Yo joined members of the CSO and CPS students in a special performance at the Thompson Center designed to bring attention to the importance of the arts in the lives of students.
Get the full details about these grants from the Mayor's Office.
Read more from Mark Caro in the Chicago Tribune.
12/12/2013 04:36 pm
The Second City Guide to the Opera, the groundbreaking collaboration by Lyric Opera of Chicago and The Second City, wins Jeff Awards for Best Production: Revue and Best Director: Revue!
The Second City Guide to the Opera, the groundbreaking collaboration by Lyric Opera of Chicago and The Second City, won Jeff Awards for Best Production: Revue and Best Director: Revue during the 45th annual Jeff Equity Awards gala on Monday. The ceremony took place at Drury Lane Theatre in Oakbrook Terrace, Illinois. "This is the first time Lyric Opera of Chicago has been nominated, and to win this prestigious award is truly thrilling," said Anthony Freud, Lyric's general director.
The Jeff Awards are billed as "a celebration of excellence in Chicago theatre" and have honored outstanding theater artists annually since 1968. During the 2012-13 season, Jeff Awards judges attended opening nights of 143 Equity productions offered by 52 producing organizations. From these openings, 109 productions were "Jeff Recommended" and eligible for award nominations, resulting in 166 nominations in 36 categories.
The Second City Guide to the Opera premiered in a sold-out, one-night-only performance in the Civic Opera House on January 5, 2013. Lyric Opera creative consultant Renée Fleming had the idea to bring together the world-renowned comedy troupe and opera company, both legendary Chicago institutions, to see what kinds of creative sparks might fly. "This unexpected mash-up of opera and sketch comedy was a great way to show die-hard opera fans – and new audiences – a fun side of our centuries-old art form," said Fleming.
The resulting revue-style show featured opera-themed comedic sketches performed by ensemble members of The Second City and The Patrick G. and Shirley W. Ryan Opera Center, with Fleming and legendary stage and screen actor Sir Patrick Stewart sharing emcee duties and appearing in sketches and satirical vignettes. Lyric Opera Orchestra musicians and revue music director Jesse Case (music director for The Second City e.t.c.) provided accompaniment. Case, Tim Sniffen, and Kate James wrote the material; The Second City's Billy Bungeroth directed, and TSC's Kelly Leonard was executive producer.
The resounding success of the January performance led to a month-long run of cabaret-style performances May 31-June 30, with audience and performers onstage at the Civic Opera House. It was this 23-show run (including new material) that was seen by Jeff-Award judges.
Performers for the extended run were Second City ensemble members Joey Bland*, Molly Brennan, Lilli-Anne Brown, Beth Melewski*, Tim Ryder, and Timothy Sniffen*. Billy Bungeroth* was director, Jesse Case* was music director and writer, and Kate James* and Timothy Sniffen* were writers. Singers from Lyric were mezzo-soprano Lauren Curnow and tenor Bernard Holcomb*, both former members of the Ryan Opera Center. (*participated in the January show) Musicians for the early-summer shows were Jesse Case/piano and guitar, John Macfarlane/violin, and Laura Deming/cello (both members of the Lyric Opera Orchestra).
The Second City Guide to the Opera is a project of Lyric Unlimited, a multifaceted program of expanded community engagement and artistic initiatives.
All performances of The Second City Guide to the Opera were sponsored by PNC Bank.
For more information on the Jeff Awards, click here.
For more information on Joseph Jefferson III, the 19th-century actor for whom the awards are named, click here.
11/7/2013 01:48 pm
Join us in celebrating National Opera Week with A Week in the Life of Lyric Opera! October 25 through Sunday, November 3.
Join us in celebrating National Opera Week with "A Week in the Life of Lyric Opera"!
From Friday, October 25 through Sunday, November 3, Lyric will celebrate our wonderful artists, administrators, and audience members of all ages who participate in our wide-ranging programs—both at the opera house and in the community—by sharing photos on Facebook, Twitter, Instagram, and here on our blog (photos will be added throughout the week so check back often!). "A Week in the Life of Lyric Opera" showcases our vast Lyric family and community!
We encourage you to take pictures to show off the role opera plays in your life, too! Do you listen to a recording while you work out? Sing in a community chorus? Play an instrument? Or just sit back and relax with one of the classics and a glass of wine? Print and pose with one of our signs in your photos, or make your own! Then post your photos to your own social media accounts as often as you'd like throughout the week—simply tag Lyric Opera and use #operaweek to be included.
Facebook: facebook.com/LyricOperaTwitter: @LyricOperaInstagram: lyricopera
10/24/2013 09:51 pm
Lyric Opera of Chicago opens its doors to the public as part of Chicago Architecture Foundation's free Open House Chicago, October 19-20.
Get a soprano's-eye view from the stage! Art-Deco lobby, foyer, and theater of the Civic Opera House accessible Saturday, October 19, 9am–2pm and Sunday, October 20, 9am–5pm.
Brief onstage vocal performances hourly on Saturday between 10am and 1pm.
Lyric Opera of Chicago will open the doors to the Civic Opera House October 19-20 for free public viewing as part of The Chicago Architecture Foundation's Open House Chicago. Visitors will have access to the stunning Rice Grand Foyer and Ardis Krainik Theatre, and will have the opportunity to stand onstage for a soprano's-eye view!
On Saturday, guests may also experience live vocal performances with piano accompaniment. At 10am, 11am, 12pm, and 1pm, ensemble members of The Patrick G. and Shirley W. Ryan Opera Center of Lyric Opera of Chicago will perform in the auditorium of the Civic Opera House, which opened in 1929 and is noted for its beautiful Art-Deco décor.
Lyric Opera of Chicago is among the 150 sites featured during Open House Chicago, a free public festival that offers behind-the-scenes access to 150 buildings across Chicago for one weekend annually.
This is a project of Lyric Unlimited, a long-term, evolving initiative that encompasses company activities outside of Lyric's mainstage season. Lyric Unlimited offers a multifaceted program of community engagement and artistic initiatives and includes Lyric's longstanding education programs.
For more information: openhousechicago.org.
Follow Lyric on Twitter @LyricOpera. #OHC2013.
Saturday visitors to the Civic Opera House will have the added option of seeing Lyric's annual OPERATHON fundraiser being broadcast live on 98.7WFMT from the street-level Pedersen Room restaurant at the Civic Opera House.
10/17/2013 01:09 pm


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Cost of Teeth Implants in Seoul – Korea |
Updated: Jeff on March 30th, 2012 | no responses. |
Do you want to get your missing teeth replaced but are terrified by the mere thought of the cost of the dental treatment? Not anymore! If you know the right place to go to, low-cost dental implant treatment is very much a reality. The cost of teeth implants in Seoul, Korea is only a fraction of the cost of like-procedures in nations such as the US, Australia, Canada, and the UK. Though dental implants offer an effective solution to missing teeth, their extortionate costs, especially in the West, are a huge deterrent for dental patients. While many people choose to live with their dental problems, others do not mind traveling to distant lands to find affordable solution for their missing teeth. Dental tourism in South Korea has been propelled by the spurt in the number of state-of-the-art dental clinics that offer easy on the pocket treatments. Medical and Dental Tourism in KoreaMedical tourism in Korea is still in its nascent stage. As per a report titled Korea Reaps Surplus in Medical Tourism by Kim Tong-hyung published on the Medical Korea website on April 7, 2011, Korea earned a $2.2 million surplus in the medical tourism industry. As Korea has been recognized as one of the global stalwarts in terms of medical technology used and the quality of care provided, medical tourism, including dental tourism, in Korea is bound to experience an increasing trend. As per another article titled Korea Becoming a Hub for Medical Tourism by Tony Michell, Managing Director of Korea Associates Business Consultancy, published in the Korea Times on October 26, 2011, the Korean government has set a goal of receiving one million medical tourists by 2020. Tooth Implant Cost in Korea
Why Get Teeth Implants in Korea?Besides the low cost of teeth implants in Seoul Korea, here are some of the other upsides to choosing to get treated there -
The affordable cost of teeth implants in Seoul, Korea is a breather for people who cannot afford the exorbitantly priced prosthetics in their home countries. South Korea's reputable dental facilities dispense quality services and engage the services of qualified and skilled dentists. DentaVacation facilitates affordable dental treatments at various destinations across the world. For more information, submit the estimate-request form on the right. Related Posts |
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Sherry Dobbin
Adjunct Assistant Professor of Policy
Sherry Dobbin is the Director of Public Art for Times Square Arts, the public art program of the Times Square Alliance. Ms. Dobbin brings over 20 years international experience across performance and visual arts, and art in the public realm, where she has worked as producer, administrator, consultant and curator. Prior to Times Square, she was the Director of Robert Wilson's The Watermill Center and a Project Director of arts-led regeneration throughout London and Eastern UK. She is a Fellow of the Royal Society of Arts (UK), and holds a Masters with Distinction from University of London, Birkbeck College in Cross-disciplinary Arts History and a BFA in Theater Studies from Boston University College of Fine Arts.
Semester | Course |
Spring 2014 |
The Arts and Artist in Urban Revitalization
This seven-week course addresses the role of arts institutions, artists and public art in revitalizing cities, with an emphasis on comparative domestic and international examples of distinctive interventions and the larger lessons that can be drawn from them. We examine how the economic, geographic and social context shapes both art and its role with respect to public policy goals. Students will refine their ability to analyze existing projects and programs and plan creative interventions as tools for revitalizing cities. In the process, we will also examine and broaden the definition of public art. The class is appropriate for those interested in both public policy, planning and administration as well as arts-based practice and theory. Download Syllabus |


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Brand new 27x40 inch original US One Sheet movie poster of Jack Ryan: Shadow Recruit featuring Chris Pine and Kevin Costner and Keira Knightley
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California bungalows and craftsman bungalows were variations of an affordable housing type that swept across America in the early twentieth century. These homes used double hung and casement/awning windows with larger profiles and interesting grid patterns (often just at the top of a picture window). This architectural style is known for having many windows and abundant light. Many of these homes have wood features that the windows may match or complement. Fiberglass windows and French patio doors with wood interiors are an excellent choice for replacement windows and doors in these homes.
Craftsman/Bungalow Architectural Style (3 images)
Craftsman/Bungalow Recommended Windows
Double Hung grid windows in combination with casement/awning or picture windows help create the patterns that Bungalow style houses are typically associated with. Bungalow style houses typically have ample light, and combinations of larger grid windows provide plenty of natural light.
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Craftsman bungalows offer the perfect canvas for Essence or Ultra Series windows and doors – offering a broad range of styles to put the finishing touches on a Bungalow style home.


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Bass TabsBass Tabs v2ChordsChords v2TabsTabs v2Tabs v3Ukulele
My first tabs. C Am You don't always have to fuck her hard, In Dm G Fact sometimes that's not right ... to do. C Am Sometimes you gotta make some love Dm G And fuckin give her some smooches too Am F Sometimes you got to squeeze Am F Sometimes you got to say please C G Sometimes you got to say hey: C Am I'm gonna fuck you .... softly Dm G I'm gonna screw you gently C Am I'm gonna hump you.... sweetly Dm G I'm gonna ball you ... discretely--- Am F And then y ou say, Hey I brought you flowers C G And then you say, Wait a minute sally! C F Dm I think I got something in my teeth could you get it out for me? G That's fuckin' Teamwork! C Am What's your favorite posish? Dm G C That's cool with me it's not my favorite but I'll do it for you Am What's your favorite dish? Dm G I'm not gonna cook it but I'll order it from Zanzibar! Am F And then I'm gonna love you completely C G And then I'll fuckin' fuck you discretely Am F And then I'll fuckin bone you completely C But then... Dm G Dm F C I'm gonna fuck ---- you ----- haaaaaaaaaard------- FUCK YOU! Comments
Popular Tenacious D tabs & chords Song lyrics
↑ Back to top | Tablatures and chords are parodies/interpretations of the original songs. You may use it for private study, scholarship, research or language learning purposes only |


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Morgan Stanley
Morgan Stanley Sales and Trading Associate Salary
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Gordon User Guide: Managing Your Accounts
The show_accounts command lists the accounts that you are authorized to use, together with a summary of the used and remaining time.
[user@gordon-ln ~]$ show_accounts ID name project used available used_by_proj --------------------------------------------------------------- <user> <project> <SUs by user> <SUs available> <SUs by proj>
To charge your job to one of these projects replace << project >> with one from the list and put this PBS directive in your job script:
#PBS -A << project >>
Many users will have access to multiple accounts (e.g. an allocation for a research project and a separate allocation for classroom or educational use). On some systems a default account is assumed, but please get in the habit of explicitly setting an account for all batch jobs. Awards are normally made for a specific purpose and should not be used for other projects.
Adding users to an account
Project PIs and co-PIs can add or remove users from an account. To do this, login to your XSEDE portal account and go to the add user page.
The charge unit for all SDSC machines, including Gordon, is the SU (service unit) and corresponds to the use of one compute core for one hour. Keep in mind that your charges are based on the resources that are tied up by your job and don't necessarily reflect how the resources are used.
Unlike some of SDSC's other major compute resources, Gordon does not provide for shared use of a compute node. A serial job that requests a compute node for one hour will be charged 16 SUs (16 cores x 1 hour), regardless of how the processors-per-node parameter is set in the batch script.
The large memory vSMP nodes on the other hand can be shared by multiple jobs. Be sure to request as many cores as your job needs, but be aware that if you request all 128 cores within a vSMP node your job will be charged at the rate of 128 SUs per hour.


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Carnival Triumph Towed to Mobile Feb. 15, 2013
Friday, February 15, 2013 10:41 AM
Inappropriate photo? Alert us.
The Carnival Triumph is docked after being towed to the Alabama Cruise Terminal in Mobile, Ala., Friday, Feb. 15, 2013. Nicole Brown, a nurse from Dallas, left, pictured with relatives, collected approximately 3,000 signatures on two bed sheets from her trip aboard the cruise ship Carnival Triumph. (Mike firstname.lastname@example.com)
Related articles
- Carnival Triumph leaves Alabama Cruise Terminal where docking was 'perfect' February 15, 2013, 10:03 AM
- Ending five-day towing of Carnival Triumph, Coast Guard now turns toward investigation February 15, 2013, 10:08 AM


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The single released by this year's winner of The X Factor will also be the show's charity song, it has been announced.
The song, which has yet to be announced, will raise money for children's charity Together for Short Lives, which provides support for children with life-threatening illnesses and their families.
It will be performed by the last two finalists in the competition before being released after the winner is revealed next week.
Syco says it will donate 100% of its profits from the sale of each CD single and download to Together for Short Lives. This is expected to be at least £1 for each CD and 20p for each download.
Simon Cowell, who has worked closely with Together For Short Lives for many years, said:
"Together for Short Lives is such an inspiring and important charity for so many kids and their families who really need help and support. These hospices are really happy and positive places and are a complete lifeline for so many families."
I'm delighted that The X Factor's winner single sales will go directly to helping them.Simon Cowell
I'm delighted that The X Factor's winner single sales will go directly to helping them.
Simon Cowell
"Having worked with this charity for many years I have been able to see first-hand how they have impacted so many lives," he added.
Barbara Gelb, CEO of Together for Short Lives added: "We are so delighted to benefit from The X Factor Charity single this year.
"Together for Short Lives is the leading UK charity that speaks for all children with life-threatening and life-limiting conditions and all those who support, love and care for them. Our work helps to ensure that children can get the best possible care, when and where they need it.
"We work with the specialist services that care for these children and families, including children's hospices, and every single bought will make a huge difference. These services are a real lifeline and your money will help to support families with the challenges of daily life so children and families make the most of precious time together."
The single will be the fifth charity release from The X Factor, following last year's cover of the Rose Royce classic 'Wishing On A Star'.


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"We're The Kids" now available on iTunes » bit.ly/10OakcA « Visit fb.com/paradeoflights for more info.
Instagram » instagram.com/paradeoflightsmusic
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Avean is a singer-songwriter and producer based in LA here to bring you some soul-stirring tracks.
Available NOW on iTunes: goo.gl/ka9SP
Like Avean on Facebook: www.facebook.com/aveanofficial
Pizza Guy, from the long awaited follow up EP to his classic singles 'Real Talk' (with Anna Lunoe) and 'Body Stop'.
This release also includes 'Show Me' and a 'Pizza Guy' remix by Lauer.
iTunes: bit.ly/1316ZbS
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With twelve tracks of languid harmony and reverb, Habit Shackles (available on July 16th) is certain to resonate with fans of Nico, Cat Power and their ilk.
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Here is a smooth remix by the up & rising french producer LE CRAYON, of our track 'Toy Boy' out in March 2013.
It is also featured on the compilation "Electro Lab vol.1" released thru Wagram
"Glitter and Gold" iTunes release date: 7/9/13
"Tunnel Vision" EP release date: 8/6/13
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Hello, My box is beginning to get a bit crowded, and I am thinking about taking some of the worms out to set up a composting bin for my friend. What is the most ideal way to transport them? Can I put them all in a small plastic yogurt container with holes in it for a few hours? He lives 45 minutes away from me. He will have the box prepared by the time I get there. Or should I just make an entirely new bin at my home and carry it all to my friends house? I don't want to do this because its so heavy and I am taking the bus, but if this is what I have to do to ensure the worm's safety, then I will. But I know that people order worms on the internet. What kind of packaging are they in?! |
This post was edited by homeinametronome on Sat, Feb 16, 13 at 21:54
Follow-Up Postings:
- Posted by billthewormman none (My Page) on Sun, Feb 17, 13 at 14:41
You will do alright if you just put them into another plastic container (like a yogurt jug) with some vermicompost and fresh bedding. Just make sure you poke lot's of holes to ensure it has good ventilation. The best way to get your friend going is to try and pick out breeding adults from your bin to give to him. That will ensure they begin to populate his bin immediately. |
What I would do is give your friend some vermicompost from your bin first (no worms). Have him mix this into his new bins bedding, wait a couple of weeks for the bedding to "ripen" and then give him the worms. The worms will basically be moving back "home" and there shouldn't be too much stress on them. The new bin will have the same microherd that were in the original bin at your house and will have had time to start the composting that feeds the worms. Also, the yogurt container will be fine for the transfer. |
I think sending them via carrier pigeon would be optimal. Just put them in a tub or bag and drive over. |
Go with the yogurt container. If it is only an hour or so, you don't really need to poke holes. Grab a handful or two of bedding from your bin, and the worms that come with it, put them in the yogurt container, and be on your way. The worms will be fine. |
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Reviewed By John B (BROOKFIELD, WI) Reviewed for a 2008 Audi A4 —5/29/2013 6:59 PM
Good Quality Mats Color I Chose...OEM Color...Not A Good Match
Reviewed By Kerry F (HOLLAND, MI) Reviewed for a 2009 Audi A4 —7/2/2014 4:37 AM
Great fit in both front and back. Lines up perfectly with the hold down tabs in front. Perfect line to line fit. The back mats fit great, but do have a tendency to move a little bit. Overall they look great. Have had them for only a little while, so don't know about durability yet. Kind of concerned about the heel point under the gas pedal. So far, very happy with the purchase. Nice thick, quality feel with solid seams around the edges.
Reviewed By Harold S (LEHI, UT) Reviewed for a 2013 Audi A4 —4/3/2013 7:49 AM
I have used your mats in my last 2 Audi's. The mats lasted and still looked good after 210,000 and 205,000 miles respectively. They give the car a feeling of luxury that is above the standard floor mats that Audi sends with the cars. The original mats are good but you mats are exceptional.


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The Neuropsychology Service provides a range of services to adults and children receiving treatment at the Comprehensive Epilepsy Center. Services for adults with epilepsy include neuropsychological testing and a group-oriented approach to memory treatment. Information from standardized testing helps identify difficulties in cognition and/or behavior that might influence a patient's diagnosis and treatment. Pediatric services include assessment of cognitive and behavioral disorders related to epilepsy, in addition to evaluations of learning and communication issues relevant to performance in a school setting.
Neuropsychological testing also provides detailed information for adults and children who are considered surgical candidates. The test results will help determine strengths and weaknesses and provide a baseline to measure postsurgical functioning. Members of the neuropsychology service also perform a range of specialized procedures for surgical candidates, including the Wada Test (link to wada test in "testings and services") and Brain Mapping (link to brain mapping in "testings and services") of language zones. All of these services are offered in both English and Spanish.
Other Clinical Services
The Neuropsychology Service welcomes referrals from neurologists, psychiatrists, and other medical professionals from NYU Langone Medical Center and the community at large. All of our staff neuropsychologists have extensive training in neuropsychological assessment of a variety and are board certified through the American Board of Clinical Neuropsychology.
Services are provided to patients receiving treatment through this center's Cognitive Neurology Program. These include neuropsychological testing of memory disorders, dementia, and other neurobehavioral syndromes. Our adult neuropsychologists accept referrals from the community for evaluation of similar issues. Specialized services involving forensic evaluations and assessment of sports concussion are also available. Our pediatric specialist also accepts referrals from local schools and pediatricians, for assessment of language, learning, and attention deficits in children.


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Card Idea: Morning GloriesMake this card using our rubber art-stamp designs!
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Hi all first time ford owner driven a few never owned one
I am now the proud owner of a 60 plate Smax titainium in ice white after trading in my grand c4 picasso. Absolutely loving the car although the converse plus system went faulty 3 days after delivery but ill save that for another post.
A big Hello the all.


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David A. Dorr, M.D., M.S.
- Specialty:
- Medicine
- Special Interest:
- Internal Medicine
- Accepting Patients:
- No
- Languages:
- English
Dr. Dorr earned his bachelor's degree in economics and his medical degree from Washington University, St. Louis. He then completed his internal medicine residency at OHSU, and earned a master's degree in medical informatics and health services administration from the University of Utah. He did several years of biostatistical consulting during undergraduate and medical school. His interests lie in collaborative care, chronic disease management, quality and the requirements of clinical information systems to support these areas. He also is interested in patient safety. Dorr is board certified in internal medicine.Dr. Dorr is interested in providing the best care for older adults and those with chronic diseases. He has worked on longitudinal care management systems that help keep better track of patients' needs and goals, help them to manage their own conditions better, and make them feel like a valued member of the team.
Internal Medicine -
Medical Informatics -
Internal Medicine


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Court of Appeals Visit
The Oregon Court of Appeals visits the law school annually to hear arguments in real cases. The event is held in the law school's courtroom, providing LRW students with an up-close observation of the Court of Appeals in action. Between arguments, students have an opportunity to ask questions of the judges and the attorneys. The court's most recent visit was Thursday, January 16, 2014. For information on the cases that were argued, please visit the links below.
Lisa Chernaik v. John Kitzhaber
Casey J. Deckard v. Diana L. Bunch
The photos on this page are from prior visits of the Court of Appeals: Judge David Schuman (now retired and teaching at Oregon Law) questioning an advocate; an attorney presenting his case; a law clerk (a UO grad) listening to arguments.


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Makes 8 servings
- 1/2 cup apricot preserves
- 1/4 cup sweet-hot mustard
- 2 teaspoons chopped fresh rosemary
- 2 tablespoons vegetable oil
- 18 ounces breakfast sausage links (such as pork links or hot and sweet links; about 20 links)
Whisk apricot preserves in heavy medium saucepan over medium heat until melted and smooth, about 1 minute. Add mustard and whisk until beginning to simmer, about 30 seconds. Remove from heat. Stir in chopped rosemary. Season glaze to taste with salt and pepper. (Can be made 1 day ahead. Cover and refrigerate. Stir over medium heat until heated through.)
Heat oil in heavy large skillet over medium-high heat. Add sausages and sauté until browned and cooked through, about 10 minutes. Transfer to saucepan with glaze. Stir over medium heat until sausages are glazed, about 1 minute. Transfer to platter and serve.
my notes
- Calories289
- Carbohydrates15 g (5%)
- Fat22 g (34%)
- Protein8 g (16%)
- Saturated Fat6 g (32%)
- Sodium677 mg (28%)
- Polyunsaturated Fat3 g
- Fiber0 g (2%)
- Monounsaturated Fat11 g
- Cholesterol37 mg (12%)


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The St. Louis Family
In January 1971, the St. Louis Globe-Democrat reported that the Missouri Task Force on Organized Crime had released the results of a yearlong study on organized crime in the state. The 15-member task force claimed that organized crime in St. Louis was "engaged in labor racketeering, gambling, infiltration of legitimate businesses, loan sharking, and narcotics traffic." Three factions were identified as cooperating in illegal activities. The first group was "headed by Anthony Giordano, with John Vitale second in command," and maintained strong ties with the Detroit syndicate." Aging, former Cuckoo gangster Jimmy Michaels headed the second group; and the last group was identified as "remnants of the East Side gang that was once headed by the late Frank "Buster" Wortman."
The report went on to state that the Giordano faction was heavily dependent on gambling, from operations in the north and northwest areas of St. Louis, as its main source of income. It also claimed that in addition to gambling, the group was into disposal of stolen property and had infiltrated legitimate businesses, including the Banana Distributing Company owned by Giordano, a produce trucking company, and the aforementioned Metropolitan Towing Company. The Task Force's findings accused the Giordano led faction of using the Metropolitan Towing Company to launder illegal income and provide an outlet to market stolen auto parts.
What concerned the committee was that all three factions had infiltrated organized labor. Authorities estimated that at least 30 mobsters were working as business agents for the unions, including relatives of both Giordano and Jimmy Michaels.
In conclusion to the committee's findings, it is interesting to note that in 1997, a former police official stated, "it behooved police to puff up the local organized crime situation because by doing so, the department became eligible for mob-fighting grants from the Nixon administration."
During the mid-1970s, Giordano was indicted after he attempted to gain hidden ownership in the Frontier casino in Las Vegas. Convicted with him were Detroit mobsters Michael Polizzi and Anthony Zerilli. Giordano was sent to prison in 1975 and released in December 1977. Giordano was nominated for Nevada's infamous Black Book on March 4, 1975, but because he had been sent to prison for the infraction, he was removed in April of the following year.
Another tie between St. Louis and Las Vegas was through Morris Shenker. Described as veteran defense attorney from St. Louis, Shenker represented Teamsters' President James R. Hoffa beginning in the mid-1960s and quickly made his way up the ranks of the "Teamsters' Bar Association." He also represented leading racketeers in St. Louis and was active in Democratic politics. His client list of organized crime figures not withstanding, Shenker was appointed by St. Louis Mayor A. J. Cervantes to serve as chairman of the city's new Commission on Crime and Law Enforcement. He resigned amid allegations that money from a $20 million dollar federal grant to fight crime was going unauthorized to the commission.
Former St. Louis Post-Dispatch reporter Ronald J. Lawrence said of Shenker:
"There is a tendency to dismiss as inconsequential the tremendous influence and power wielded inside and outside the underworld by Morris Shenker, a functionary for the St. Louis, Kansas City, Chicago and other families. This largely was because most local law enforcement officers were unable to comprehend the complexity of the man and his operations."
"Shenker, a lawyer who once represented Jimmy Hoffa, was a mover and shaker and a financial genius of the caliber of Lansky. It was Shenker who tapped the Teamster Union's Central States Pension Fund to finance much of the mob's penetration of Las Vegas casinos and other ventures. Shenker's influence extended far beyond the underworld and he was able to get two of his own federal indictments killed."
"St. Louis underworld interests controlled two Las Vegas casinos the Dunes, owned by Shenker, and the Aladdin."
As early as November 1974, the St. Louis Post-Dispatch was reporting that Vincenzo "Jimmy" Giammanco and Matthew M. Trupiano Jr. (both sons of Giordano's sisters) were in line to replace Giordano before he was sent away to prison. The paper also discussed the possibilities of a mob war between the mafia and the Syrians, led by Jimmy Michaels, for control of several labor unions.
On February 12, 1979, the St. Louis Post-Dispatch ran a story that Giordano was directing organized crime activity in Colorado. The paper quoted an unnamed source as stating, "Giordano is not just an errand boy. He is overlord for Colorado and he is the commission's representative here. Territories and geographical boundaries are not important. Relationships between people are paramount, and Giordano provides that relationship with the top of the mob."
The article went on to say that Giordano, working with the Smaldone Family Eugene "Checkers," Clyde "Flip Flop," and Clarence "Chauncey" oversees gambling, loan sharking, major fencing and investments into legitimate businesses. Giordano's dealings with the Smaldones began in 1973. Authorities believe it was through this relationship that "organized crime attempted to gain control of the Pueblo, Colorado Police Department in 1977 through the selection of two St. Louisans as candidate for chief of police."
The article also revealed that influences in Colorado by the St. Louis mob went back to the mid-1960s when St. Louis gangster Sam Shanks went there to help the Smaldones re-establish control of the gambling interests after they were released from a long prison term for jury tampering. During this time, Shanks murdered a gambler turned informant. Later Shanks retired to St. Louis and was a confidant of Giordano.
On August 29, 1980, Giordano died from cancer at his South St. Louis home. He was 67. Ten days before his death, a meeting was held at the Howard Johnson's Motor Lodge at Interstate 44 and Hampton Avenue. The meeting, with members of the Colorado underworld present, was called to choose a successor. Giordano's choice was said to be his nephew, Jimmy Giammanco. However, some family members balked at the decision and instead supported Joseph Cammarata, an ex-convict who had been keeping a low profile. Reports stated Giammanco threatened Cammarato when the decision was made to promote him. When neither candidate seemed to emerge, Anthony M. "Nino" Parrino, an officer of Teamster's Local 682, was considered.


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Abstract: | Abstract Several psychiatric and neurological conditions affect the semantic organization and content of a patient's speech. Specifically, the discourse of patients with schizophrenia is frequently characterized as lacking coherence. The evaluation of disturbances in discourse is often used in diagnosis and in assessing treatment efficacy, and is an important factor in prognosis. Measuring these deviations, such as "loss of meaning" and incoherence, is difficult and requires substantial human effort. Computational procedures can be employed to characterize the nature of the anomalies in discourse. We present a set of new tools derived from network theory and information science that may assist in empirical and clinical studies of communication patterns in patients, and provide the foundation for future automatic procedures. First we review information science and complex network approaches to measuring semantic coherence, and then we introduce a representation of discourse that allows for the computation of measures of disorganization. Finally we apply these tools to speech transcriptions from patients and a healthy participant, illustrating the implications and potential of this novel framework. |
URI: | http://hdl.handle.net/10037/4094 |
Abstract: | The notoriously multi-resistant Staphylococcus haemolyticus is an emerging pathogen causing serious infections in immunocompromised patients. Defining the population structure is important to detect outbreaks and spread of antimicrobial resistant clones. Currently, the standard typing technique is pulsed-field gel electrophoresis (PFGE). In this study we describe novel molecular typing schemes for S. haemolyticus using multi locus sequence typing (MLST) and multi locus variable number of tandem repeats (VNTR) analysis. Seven housekeeping genes (MLST) and five VNTR loci (MLVF) were selected for the novel typing schemes. A panel of 45 human and veterinary S. haemolyticus isolates was investigated. The collection had diverse PFGE patterns (38 PFGE types) and was sampled over a 20 year-period from eight countries. MLST resolved 17 sequence types (Simpsons index of diversity [SID] = 0.877) and MLVF resolved 14 repeat types (SID = 0.831). We found a low sequence diversity. Phylogenetic analysis clustered the isolates in three (MLST) and one (MLVF) clonal complexes, respectively. Taken together, neither the MLST nor the MLVF scheme was suitable to resolve the population structure of this S. haemolyticus collection. Future MLVF and MLST schemes will benefit from addition of more variable core genome sequences identified by comparing different fully sequenced S. haemolyticus genomes. |
URI: | http://hdl.handle.net/10037/4354 |
Abstract: | Health care in Canada's north and circumpolar regions faces considerable challenges with the remote and widely dispersed population, harsh environmental conditions, and human resource challenges. Despite per capita expenditures that are among the highest in the world, health outcomes continue to lag behind the rest of Canada, and health disparities between the Indigenous and non-Indigenous populations within the north persist. While improving the health of northerners requires addressing underlying social determinants, transforming the health care system holds promise for health improvements in the short- and medium-term . The evidence required to inform a northern-focused and relevant transformation of health care systems remains to be generated and applied. This seminar set out to identify priority areas for a research initiative that will address systems challenges and engage decision-makers in these jurisdictions. The overarching objectives of the seminar were to explore the priority areas for health systems research in circumpolar regions, and to propose how we might best maximize our current resources, and facilitate partnerships for the advancement of a common agenda. |
URI: | http://hdl.handle.net/10037/6011 |
Abstract: | Chinese herbs are thought to be effective for type A H1N1 influenza. Series of Chinese herbs have been authorized recommended by the Chinese government, and until now a number of clinical trials of Chinese herbs for H1N1 influenza have been conducted. However, there is no critically appraised evidence such as systematic reviews or metaanalyses on potential benefits and harms of medicinal herbs for H1N1 influenza to justify their clinical use and their recommendation. CENTRAL, MEDLINE, EMBASE, CBM, CNKI, VIP, China Important Conference Papers Database, China Dissertation Database, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs) of Chinese herbs for H1N1 influenza till 31 August, 2011. A total of 26 RCTs were identified and reviewed. Most of the RCTs were of high risk of bias with flawed study design and poor methodological quality. The combination of several Chinese herbal medicines with or without oseltamivir demonstrated positive effect on fever resolution, relief of symptoms, and global effectiveness rate compared to oseltamivir alone. However, only one herbal medicine showed positive effect on viral shedding. Most of the trials did not report adverse events, and the safety of herbal medicines is still uncertain. Some Chinese herbal medicines demonstrated potential positive effect for 2009 type A H1N1 influenza; however, due to the lack of placebo controlled trial and lack of repeated test of the intervention, we could not draw confirmative conclusions on the beneficial effect of Chinese herbs for H1N1 influenza. More rigorous trials are warranted to support their clinical use. |
URI: | http://hdl.handle.net/10037/3961 |
Abstract: | TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may reduce wildtype p53 protein activity. Here, we explored the predictive and prognostic value of TP53 and CHEK2 mutation status together with MDM2 SNP309 genotype in stage III breast cancer patients receiving paclitaxel or epirubicin monotherapy. Each patient was randomly assigned to treatment with epirubicin 90 mg/m2 (n= 109) or paclitaxel 200 mg/m2 (n = 114) every 3rd week as monotherapy for 4–6 cycles. Patients obtaining a suboptimal response on first-line treatment requiring further chemotherapy received the opposite regimen. Time from last patient inclusion to follow-up censoring was 69 months. Each patient had snap-frozen tumor tissue specimens collected prior to commencing chemotherapy. While TP53 and CHEK2 mutations predicted resistance to epirubicin, MDM2 status did not. Neither TP53/ CHEK2 mutations nor MDM2 status was associated with paclitaxel response. Remarkably, TP53 mutations (p = 0.007) but also MDM2 309TG/GG genotype status (p = 0.012) were associated with a poor disease-specific survival among patients having paclitaxel but not patients having epirubicin first-line. The effect of MDM2 status was observed among individuals harbouring wild-type TP53 (p = 0.039) but not among individuals with TP53 mutated tumors (p.0.5). TP53 and CHEK2 mutations were associated with lack of response to epirubicin monotherapy. In contrast, TP53 mutations and MDM2 309G allele status conferred poor disease-specific survival among patients treated with primary paclitaxel but not epirubicin monotherapy. |
URI: | http://hdl.handle.net/10037/3971 |
Abstract: | Background: Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased
sinusoidal flow per se and hence the shear-stress stimulus on the endothelial surface within the liver remnant which is the main stimulus to regeneration. In order to test this hypothesis we wanted to increase the sinusoidal flow without performing a concomitant liver resection. Accordingly, we constructed an aorto-portal shunt to the
left portal vein branch creating a standardized four-fold increase in flow to segments II, III and IV. The impact of
this manipulation was studied in both an acute model (6 animals, 9 hours) using a global porcine cDNA microarray
chip and in a chronic model observing weight and histological changes (7 animals, 3 weeks).
Results: Gene expression profiling from the shunted segments does not suggest that increased sinusoidal flow per se results in activation of genes promoting mitosis. Hyperperfusion over three weeks results in the whole liver gaining a supranormal weight of 3.9% of the total body weight (versus the normal 2.5%). Contrary to our hypothesis, the weight gain was observed on the non-shunted side without an increase in sinusoidal flow. Conclusions: An isolated increase in sinusoidal flow does not have the same genetic, microscopic or macroscopic impact on the liver as that seen in the liver remnant after partial hepatectomy, indicating that increased sinusoidal flow may not be a sufficient stimulus in itself for the initiation of liver regeneration. |
Description: | This article is part of Kim Erlend Mortensen's doctoral thesis, which is available in Munin at http://hdl.handle.net/10037/2893 |
URI: | http://hdl.handle.net/10037/2895 |
Abstract: | Purpose. Activity related pain may be a barrier to rehabilitation in patients with chronic musculoskeletal disorders. This study investigated patients' reports of increased pain during activity, and the association between such pain and psychological factors and pain variables. Method. Questionnaires from 232 adults with chronic musculoskeletal pain measured pain intensity, spread of pain and pain duration. Pain during activity was assessed both on a 11 point Numeric Rating Scale (NRS), and operationalized as a dichotomous measure, where responders defined if they experienced pain during general activity and exercise. Psychological factors were measured by the Hopkins Symptom Check List 25, the Tampa Scale for Kinesiophobia and a subscale of the Arthritis Self – Efficacy Scale. Multiple and logistic regression was used to analyse associations between increased pain during activity and associated variables. Results. Increased pain during activity was reported by 69 % of participants. Fear of movement was a significant factor for reporting increased pain during activity, both general activity and exercise, also in a subsample with low psychological distress. Other significant factors were spread of pain and a low sense of self efficacy. Conclusion. Patients with high fear of movement, large spread of pain and low self efficacy were more likely to report increased pain during activity even in the absence of psychological distress. |
Description: | Accepted manuscript version, reprinted with permission (Informa Helthcare). Published version available at http://dx.doi.org/10.3109/09638280903567877 This article is part of Elin Damsgård's doctoral thesis which is available in Munin at http://hdl.handle.net/10037/2500 |
URI: | http://hdl.handle.net/10037/3549 |
Abstract: | Background: Admission with a multidisciplinary trauma team may be vital for the severely injured patient, as this facilitates rapid diagnosis and treatment. On the other hand, patients with minor injuries do not need the trauma team for adequate care. Correct triage is important for optimal resource utilization. The aim of the study was to evaluate our criteria for activating the trauma team, and identify suboptimal criteria that might be changed in the interest of precision. The study is an observational, retrospective cohort-study. All patients admitted with the trauma team (n = 382), all severely injured (Injury Severity Score (ISS) >15) (n = 161), and all undergoing an emergency procedure aimed at counteracting compromised airways, respiration or circulation at our hospital (n = 142) during 2006-2007 were included. Data were recorded from the admission records and the electronic patient records. The trauma team activation protocol was evaluated against the occurrence of severe injury and the occurrence of emergency procedures. A total of 441 patients were included. The overtriage was 71% and undertriage 32% when evaluating against ISS >15 as the standard of reference. When occurrence of emergency procedures was held as the standard of standard of reference, the over- and undertriage was 71% and 21%, respectively. Mechanism of injury-criteria for trauma team activation contributed the most to overtriage. The emergency procedures performed were mostly endotracheal intubation and external fixation of fractures. Less than 3% needed haemostatic laparotomy or thoracotomy. Approximately 2/3 of the overtriage represented isolated head or cervical spine injuries, and/or interhospital transfers. The over- and undertriage of our protocol are both too high. To decrease overtriage we suggest omissions and modifications of some of the criteria. To decrease undertriage, transferred patients and patients with head injuries should be more thoroughly assessed against the trauma team activation criteria. |
URI: | http://hdl.handle.net/10037/3866 |
Abstract: | Introduction: The introduction of high-throughput technologies, also called -omics technologies, into epidemiology has raised the need for high-quality observational studies to reduce several sources of error and bias. Methods: The Norwegian Women and Cancer (NOWAC) postgenome cohort study consists of approximately 50,000 women born between 1943 and 1957 who gave blood samples between 2003 and 2006 and filled out a two-page questionnaire. Blood was collected in such a way that RNA is preserved and can be used for gene expression analyses. The women are part of the NOWAC study consisting of 172,471 women 30 to 70 years of age at recruitment from 1991 to 2006 who answered one to three questionnaires on diet, medication use, and lifestyle. In collaboration with the Norwegian Breast Cancer Group, every NOWAC participant born between 1943 and 1957 who is admitted to a collaborating hospital for a diagnostic biopsy or for surgery of breast cancer will be asked to donate a tumor biopsy and two blood samples. In parallel, at least three controls are approached for each breast cancer case in order to obtain blood samples from at least two controls per case. The controls are drawn at random from NOWAC matched by time of follow-up and age. In addition, 400 normal breast tissues as well as blood samples will be collected among healthy women participating at the Norwegian Mammography Screening program at the Breast Imaging Center at the University Hospital of North-Norway, Tromsø. Results: The NOWAC postgenome cohort offers a unique opportunity (a) to study blood-derived gene expression profiles as a diagnostic test for breast cancer in a nested case-control design with adjustment for confounding factors related to different exposures, (b) to improve the reliability and accuracy of this approach by adjusting for an individual's genotype (for example, variants in genes coding for hormone and drug-metabolizing and detoxifying enzymes), (c) to study gene expression profiles from peripheral blood as surrogate tissue to biomonitor defined exposure (for example, hormone) and its association with disease risk (that is, breast cancer), and (d) to study gene variants (single nucleotide polymorphisms and copy number variations) and environmental exposure (endogenous and exogenous hormones) and their influence on the incidence of different molecular subtypes of breast cancer. Conclusion: The NOWAC postgenome cohort combining a valid epidemiological approach with richness of biological samples should make an important contribution to the study of the etiology and system biology of breast cancer. |
URI: | http://hdl.handle.net/10037/1423 |
Abstract: | An increasing number of individuals with complex health care needs now receive life-long and lifeprolonging ventilatory support at home. Family members often take on the role of primary caregivers. The aim of this study was to explore the experiences of families giving advanced care to family members dependent on home mechanical ventilation. Using qualitative research methods, a Grounded Theory influenced approach was used to explore the families' experiences. A total of 15 family members with 11 ventilator-dependent individuals (three children and eight adults) were recruited for 10 in-depth interviews. The core category, "fighting the system," became the central theme as family members were asked to describe their experiences. In addition, we identified three subcategories, "lack of competence and continuity", "being indispensable" and "worth fighting for". This study revealed no major differences in the families' experiences that were dependent on whether the ventilator-dependent individual was a child or an adult. These findings show that there is a large gap between family members' expectations and what the community health care services are able to provide, even when almost unlimited resources are available. A number of measures are needed to reduce the burden on these family members and to make hospital care at home possible. In the future, the gap between what the health care can potentially provide and what they can provide in real life will rapidly increase. New proposals to limit the extremely costly provision of home mechanical ventilation in Norway will trigger new ethical dilemmas that should be studied further. |
Description: | This article is part og Knut Dybwig's doctoral thesis. Available in Munin at http://hdl.handle.net/10037/3692 |
URI: | http://hdl.handle.net/10037/3841 |
Abstract: | Home mechanical ventilation probably represents the most advanced and complicated type of medical treatment provisioned outside a hospital setting. The aim of this study was both to explore the challenges experienced by health care professionals in community health care services when caring for patients dependent on home mechanical ventilation, continual care and highly advanced technology, and their proposed solutions to these challenges. Using qualitative research methods, a grounded theory influenced approach was used to explore the respondents' experiences and proposed solutions. A total of 34 multidisciplinary respondents from five different communities in Norway were recruited for five focus groups. The core category in our findings was what health care professionals in community health care services experience as "between a rock and a hard place," when working with hospitals, family members, and patients. We further identified four subcategories, "to be a guest in the patient's home," "to be accepted or not," "who decides," and "how much can we take." The main background for these challenges seems to stem from patients living and receiving care in their private homes, which often leads to conflicts with family members. These challenges can have a negative effect on both the community health caregivers' work environment and the community health service's provision of professional care. This study has identified that care of individuals with complex needs and dependent on home mechanical ventilation presents a wide range of immense challenges for community health care services. The results of this study point towards a need to define the roles of family caregivers and health care professionals and also to find solutions to improve their collaboration. The need to improve the work environment for caregivers directly involved in home-care also exists. The study also shows the need for more dialogue concerning eligibility requirements, rights, and limitations of patients in the provision and use of ventilatory support in private homes. |
Description: | This article is part of Knut Dybwik's doctoral thesis available in Munin at http://hdl.handle.net/10037/3692 |
URI: | http://hdl.handle.net/10037/4065 |
Abstract: | The aim of this study was to explore the ethical challenges in home mechanical ventilation based on a secondary analysis of qualitative empirical data. The data included perceptions of healthcare professionals in hospitals and community health services and family members of children and adults using home mechanical ventilation. The findings show that a number of ethical challenges, or dilemmas, arise at all levels in the course of treatment: deciding who should be offered home mechanical ventilation, respect for patient and family wishes, quality of life, dignity and equal access to home mechanical ventilation. Other challenges were the impacts home mechanical ventilation had on the patient, the family, the healthcare services and the allocation of resources. A better and broader understanding of these issues is crucial in order to improve the quality of care for both patient and family and assist healthcare professionals involved in home mechanical ventilation to make decisions for the good of the patient and his or her family. |
Description: | This article is part of Knut Dybwig's doctoral thesis. Available in Munin at http://hdl.handle.net/10037/3692 |
URI: | http://hdl.handle.net/10037/3840 |
Abstract: | There is wide variation in the provision of home mechanical ventilation (HMV) throughout Europe, but the provision of home mechanical ventilation can also vary within countries. In 2008, the overall prevalence of HMV in Norway was 19.9/100,000, and there were huge regional differences in treatment prevalence. The aim of this study is to find explanations for these differences. We gathered multidisciplinary respondents involved in HMV treatment from five hospitals in five different counties to six focus group conversations to explore respondents' views of their experiences systematically. We based the analysis on grounded theory. We found that uneven distribution of ''enthusiasm'' between hospitals seems to be an important factor in the geographical distribution of HMV. Furthermore, we found that the three subcategories, 'high competence,' 'spreading competence,' and 'multidisciplinary collaboration,' are developed and used systematically in counties with 'enthusiasm.' This culture is the main category, which might explain the differences, and is described as 'wise enthusiasm.' The last subcategory is 'individual attitudes' about HMV among decision-making physicians. The most important factor is most likely the uneven distribution of highly skilled enthusiasm between hospitals. Individual attitudes about HMV among the decision makers may also explain why the provision of HMV varies so widely. Data describing regional differences in the prevalence of HMV within countries is lacking. Further research is needed to identify these differences to ensure equality of provision of HMV. |
Description: | This paper is part of Knut Dybwig's doctoral thesis. Available in Munin at http://hdl.handle.net/10037/3692 |
URI: | http://hdl.handle.net/10037/3839 |
Abstract: | Purpose: Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis.
Murine studies have indicated a close interplay between both FGF2 and platelet-derived growth factor –B (PDGF-B) as well as FGF2 and vascular endothelial growth factor -3 (VEGFR-3). This study investigates the prognostic impact of FGF2 and FGFR-1 in tumor
cells and tumor stroma of resected non-small cell lung carcinomas (NSCLC) and explores the
importance of their co-expression with VEGFR-3 or PDGF-B.
Methods: Tumor tissue samples from 335 resected patients with stage I to IIIA NSCLC were obtained and tissue microarrays were constructed from duplicate cores of tumor cells and tumor-related stroma from each specimen. Immunohistochemistry was used to evaluate the expression of the molecular markers FGF2, FGFR-1, VEGFR-3 and PDGF-B. Results: In univariate analyses, high tumor cell FGF2 expression (P = 0.015) was a negative prognostic indicator for disease-specific survival (DSS). In tumor stroma, high FGF2 (P = 0.024) expression correlated with good prognosis. In multivariate analyses, high expression of FGF2 in tumor cells (P = 0.038) was an independent negative prognostic factor whereas increased FGF2 in stroma (P = 0.015) was a positive prognosticator. Tumor cell coexpressions of FGF2/VEGFR-3 (P < 0.001) and GFR-1/PDGF-B (P = 0.002) were significant indicators of poor prognosis. Conclusions: Expression of FGF2 in tumor cells is an independent negative prognostic factor, and the co-expressions of FGF2/VEGFR-3 and FGFR-1/PDGF-B are strongly associated with poor survival in NSCLC patients. |
Description: | This is the accepted version of the article. Published version available at http://dx.doi.org/10.1097/JTO.0b013e31819f2e38, © Lippincott W&W, reprinted with permission.
This article is part of Tom Dønnem's PhD thesis, which is available in Munin: http://hdl.handle.net/10037/1879 |
URI: | http://hdl.handle.net/10037/2448 |
Abstract: | Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression with VEGF-A in nonsmall cell lung cancer (NSCLC) patients. Tumor tissue samples from 335 resected stage I to IIIA NSCLC patients were obtained and tissue microarrays (TMAs) were constructed with 4 cores from each tumor specimen. VEGF-A expression was evaluated by immunohistochemistry, and in situ hybridization was used to evaluate the expression of miR-126. In the total material, miR-126 was a significant negative prognostic factor in both univariate (P = .005) and multivariate analyses (hazard ratio [HR] 1.8, 95% confidence interval [CI] 1.2-2.8, P = .01). Stratified by histology, miR-126 was only significant in squamous cell carcinomas (univariate: P < .001; multivariate: HR 3.1, CI 95% 1.7-5.6, P<.001). Stratified by lymph node status, miR-126 was significant only in the lymph node-positive subgroup (univariate: P<.001; multivariate: HR 4.1, CI 95% 2.0-8.4, P < .001). High miR-126 expression correlated significantly with high VEGF-A expression (P = .037). The co-expression of miR-126 and VEGF-A had a significant prognostic impact (P = .002), with 5-year survival rates of 68%, 51%, and 42% for low/low (n = 150), mixed combinations (n = 129), and high/high (n = 35) expression, respectively. miR-126 is a strong and independent negative prognostic factor in NSCLC, and its prognostic impact appears related primarily to histology and nodal status. Cancer 2011. © 2011 American Cancer Society. |
URI: | http://hdl.handle.net/10037/4072 |
Abstract: | Angiogenesis is regarded as a hallmark in cancer development, and anti-angiogenic treatment is presently used in non-small cell lung cancer (NSCLC) patients. MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. In this study we aimed to identify significantly altered miRs related to angiogenesis in NSCLC. From a large cohort of 335 NSCLC patients, paraffin-embedded samples from 10 patients with a short disease specific survival (DSS), 10 with a long DSS and 10 normal controls were analyzed. The miRs were quantified by microarray hybridization and selected miRs were validated by real-time qPCR. The impacts of different pathways, including angiogenesis, were evaluated by Gene Set Enrichment Analysis (GSEA) derived from Protein ANalysis THrough Evolutionary Relationship (PANTHER). One of the most interesting candidate markers, miR-155, was validated by in situ hybridization (ISH) in the total cohort (n = 335) and correlation analyses with several well-known angiogenic markers were done. 128 miRs were significantly up- or down-regulated; normal versus long DSS (n = 68) and/or normal versus short DSS (n = 63) and/or long versus short DSS (n = 37). The pathway analysis indicates angiogenesis-related miRs to be involved in NSCLC. There were strong significant correlations between the array hybridization and qPCR validation data. The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r = 0.17, P = 0.002), though most prominent in the subgroup with nodal metastasis (r = 0.34, P,0.001). Several angiogenesis-related miRs are significantly altered in NSCLC. Further studies to understand their biological functions and explore their clinical relevance are warranted. |
URI: | http://hdl.handle.net/10037/4430 |
Abstract: | In recent years, microRNAs (miRNAs) have been found to play an essential role in tumor development. In lung tumorigenesis, targets and pathways of miRNAs are being revealed, and further translational research in this field is warranted. MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 in non-small cell lung cancer (NSCLC) patients. Tumor tissue samples from 335 resected stage I to IIIA NSCLC patients were obtained and tissue microarrays (TMAs) were constructed with four cores from each tumor specimen. In situ hybridization (ISH) was used to evaluate the expression of miR-155. There were 191 squamous cell carcinomas (SCCs), 95 adenocarcinomas (ACs), 31 large cell carcinomas and 18 bronchioalveolar carcinomas. MiR-155 expression did not have a significant prognostic impact in the total cohort (P = 0.43). In ACs, high miR-155 expression tended to a significant negative prognostic effect on survival in univariate analysis (P = 0.086) and was an independent prognostic factor in multivariate analysis (HR 1.87, CI 95% 1.01 - 3.48, P = 0.047). In SCC patients with lymph node metastasis, however, miR-155 had a positive prognostic impact on survival in univariate (P = 0.034) as well as in multivariate (HR 0.45, CI 95% 0.21-0.96, P = 0.039) analysis. The prognostic impact of miR-155 depends on histological subtype and nodal status in NSCLC. |
URI: | http://hdl.handle.net/10037/3864 |
Abstract: | Angiogenesis has been regarded as essential for tumor growth and progression. Studies of many human tumors, however, suggest that their microcirculation may be provided by nonsprouting vessels and that a variety of tumors can grow and metastasize without angiogenesis. Vessel co-option, where tumor cells migrate along the preexisting vessels of the host organ, is regarded as an alternative tumor blood supply. Vessel co-option may occur in many malignancies, but so far mostly reported in highly vascularized tissues such as brain, lung, and liver. In primary and metastatic lung cancer and liver metastasis from different primary origins, as much as 10–30% of the tumors are reported to use this alternative blood supply. In addition, vessel co-option is introduced as a potential explanation of antiangiogenic drug resistance, although the impact of vessel co-option in this clinical setting is still to be further explored. In this review we discuss tumor vessel co-option with specific examples of vessel cooption in primary and secondary tumors and a consideration of the clinical implications of this alternative tumor blood supply. |
URI: | http://hdl.handle.net/10037/6324 |
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For new questions please post at magento.stackexchange.com, the community-run support site for the Magento community. We will be providing updates on the new forum solution soon. For questions or concerns please email email@example.com.
Let's create a corner where all things Kiwi can be discussed: From NZ tax requirements to country specific questions. Maybe someone even wants to start a Maori translation for Magento.
I am confident there are enough NZ members here to get this forum going. And if there is enough interest I volunteer to organise semi-regular meet-ups in Auckland for Magento store owners and developers.
Please introduce yourself below outlining how you Magento.
FOOMAN is a small web and design company from Auckland. Since the early beta versions of Magento we were amazed by the potential it offers. We run our own online store on Magento and offer Magento as part of our eCommerce solutions.
We are keen to hear from other store owners and exchange experiences with like-minded developers.
Hi guys
We run www.sparxdesign.co.nz specialising in affordable web design solutions.
We use Magento as our Sparx Shop Pro package!
Would be great if there were better shipping options for Magento for New Zealanders though?
Talk soon
We are just about to drop our online clothing store...... has taken a wee while to get it sorted, but you guys know how it goes. I have also just finished a design for another company with the development to start asap.
Hey Sparx, what kind of shipping options were you after? More integration with the NZ shipping companies?
Hi all
I run www.unicycle.co.nz and am responsible for setting web strategy. The US store www.unicycle.com is going live on Magento shortly, with others to follow. I'm also doing stuff for some other customers, and building a few modules (event calendar, wiki, customer log).
It will be good to meet up and swap some ideas: I'm finding the lack of documentation really slows things down: a 15 minute job can take all day…
Hi All,
We run a web development company that are working on providing total Magento-based eCommerce solutions. We are currently working on building a customized server build that is being performance tuned to run Magento.
We have several stores up and running woth CRE Loaded but with all that's been going on with CRE we're looking at moving to a different platform and Magento is definitely a contender. We're also looking at a couple of other options but Magento seems to have the most potential.
Will be watching with interest to see how it develops.
Hi, I run an ecommerce store selling computers, parts and electronics. Currently moving from Zen Cart to Magento once i can get Magento to import CSV file i recieve from my suppliers!
Hi there My name is Bill Bailey
I love hacking around with PHP, XHTML , CSS, XML, MySQL
I found Magento well over a year ago and I have developed New Zealand Greenstone ( it is an old version!)
I use this for testing purposes I have some early experience and you have to able to stitch together PHP XHTML CSS XML OOP I will get back to Magento soon! just have a few monkeys on my back to unload
This software platform is fantastic, "I love the way magento think, it is complex! ( not for the faint hearted )" I will be happy to be of any assistance bearing in mind i have a lot on so answers may come slowly also Im very rusty it was a year ago
You Maybe interested
Free Business Blog this site passes PR its a blogging platform meaning you can start your own blog to promote your current Business you will rank in google with in minutes best results I've had on the title search of a post was 1 min
Hey see you all soon
Regards Bill007
Hey, this is a great idea, thanks Fooman! I'm Katie, a designer based in Auckland and use Magento when my clients want an online store
Thanks Fooman, great idea. I'm looking at Magento for my next e-commerce site.
@everyone: good to see a variety of people here. I am sure more will follow as Magento gains popularity. I will see what I can do to find a venue for an informal gathering.
@Sparx: don't hesitate to open up a separate discussion about what you had in mind about shipping options.
@uni-man: the documentation is definitely a bit lacking. I think the development speed of the early versions has put quite a few people off putting together documentation - the moment it was written it wasn't accurate anymore. Have you seen the auto-generated one:
http://docs.magentocommerce.com/ ?
@Bill007: good to see you are still around. Do you want me to add your store to the collection I started in the other thread?
Hey there,
I'm Waylon Kenning, owner of a small business IT consultancy firm, at www.kenning.co.nz. I'm really interested in Mangeto as it's the first truely interesting open source e-commerce platform tailored to the customer. Unfortunately this seems to make it a little more difficult for administrators to work with, but we'll get there.
The only site I have so far is at www.sovietbadges.co.nz where I use to evaluate software. It's a live site though, so you can purchase badges if you're interested:)
Waylon Kenning - www.kenning.co.nz
My name is Mark and I run the NZ arm (since moving back here in April 08) of www.teabagstudios.com
In the past we have developed e-commerce sites using Virtuemart, OS Commerce and Cube cart. Currently have a number of Magento sites under development or scheduled for development. We are so pleased with this product compared to the previous solutions that we have used!
Will post sites here as we get them launched.
Depending on our workload I may also be looking at forging relationships with other Magento (or HTML and PHP) people.
Kia Ora, Kia ora
we are a Retail Store in Napier and are working on a site right now. shipping is the big problem right now. but hey, we can work through it right..
Arohanui fellow kiwi magentians!
Great idea Fooman, I'm using magento for a wine project.
Cheers Bruce


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Is celebrating our 25th Class Reunion!!!!
And your registration reminder is in the mail!
Don't forget to register ASAP!!!!
5 short years ago we celebrated 20 years as alumni of NJIT. And now it's time to come together again to celebrate our 25th milestone.
Mark your calendars for the weekend of May 17 - 19, 2013!
Come to re-connect with classmates, see and learn about what is happening at our alma mater plus have an outstanding time.
We promise you won't be disappointed.
Details and reservation information will be mailed out in February '13.
For those of you who missed the 20th see the recap below.
The Class of '88 reunion Committee
RECONNECTING in 2008.
On the evening of Saturday, June 7th, a group of us gathered in the beautiful new Campus Center to celebrate our 20th class reunion.
The Reunion Dinner Dance was a first class party. An elegant cocktail reception hosted by President and Mrs. Altenkirch was followed by a great dinner and a terrific band. We thoroughly enjoyed not only spending time together, but also having the opportunity to compare notes on life at NJIT with both older alums and younger ones.
Those of us who hadn't seen the campus in years just couldn't get over the changes that have taken place, from the sparkling modern buildings and the elegantly restored Eberhardt Hall to the beautiful landscaping and athletic facilities. If you haven't been back in the last few years, we promise you, it's definitely worth the trip.


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WRUW would like to say a tremendous THANK YOU to everyone who donated to our 2011 Telethon! We were able to raise more funds than ever before for the station. It was our largest telethon in history. WRUW could not have done it without all of our generous listeners and supporters across the country and the globe.
At the end of April there were still donations pouring in, and we did not break our record of "best telethon" until October when we received a large check from an apologetic listener and reached $50,493.36 raised in total-breaking our 2006 record by $200!
All of the ordered premiums have been shipped and as everyone prepares for the New Year, WRUW is preparing for our 2012 Telethon. Please consider us in April as we begin to beg yet again. 2012 is an especially important year for WRUW: it is our 45th birthday as a radio station and the 10th anniversary of our upgrade to being a 15,000 watt station.
Please contact us if you did not receive your premium from the 2011 Telethon. If you have any comments or suggestions about why 2011 was such a great year for WRUW, please email email@example.com or firstname.lastname@example.com. If you have any observations of things we could improve upon, or items that you'd like to see available in 2012, do not hesitate to tell us. When we're not talking on the radio, we're actually very good listeners!
Happy Holidays and a very prosperous New Year,
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Stockton Diagnostic Imaging Serving all of Central California & Surrounding Areas
Introduction On July 3, 1977, the first MRI exam was performed on a human being. It took almost five hours to produce one image. Dr. Raymond Damadian, a physician and scientist, along with colleagues Dr. Larry Minkoff and Dr. Michael Goldsmith, labored for seven years to reach that point. They named their original machine "Indomitable." This machine is now in the Smithsonian Institution. As late as 1982, there were a handful of MRI scanners in the United States. Today there are thousands, and images can be created in seconds what used to take hours.
The basic design of an MRI machine resembles a cube, typically measuring 7 feet tall by 7 feet wide by 10 feet long, although new models are rapidly shrinking. There is a horizontal tube running from front to back through the center of the machine which houses an extraordinary strong magnet. This tube is known as the bore of the magnet. The patient, lying on his or her back, slides into the bore on a special table. Whether or not the patient goes in head first or feet first, as well as how far in the magnet they will go, is determined by the type of exam to be performed. MRI scanners vary in size and shape, and newer or specially designed models have some degree of openness around the sides, but the basic design is the same. Once the body part to be scanned is in the exact center or isocenter of the magnetic field, the scan can begin.
In conjunction with radio wave pulses of energy, the MRI scanner can pick out a very small point inside the patient's body and ask it, essentially, "What type of tissue are you?" The point might be a cube that is half a millimeter on each side. The MRI system goes through the patient's body point by point, building up a 2-D or 3-D map of tissue types. It then integrates all of this information together to create 2-D images or 3-D models.
MRI provides an unparalleled view inside the human body. The level of detail we can see is extraordinary compared with any other imaging modality. MRI is the method of choice for the diagnosis of many types of injuries and conditions because of the incredible ability to tailor the exam to the particular medical question being asked. By changing exam parameters, the MRI system can cause tissues in the body to assume different appearances. This is very helpful to radiologists who read MRIs in determining if something seen is normal or not. MRI systems can also image flowing blood in virtually any part of the body. This allows us to perform studies that show the arterial system in the body, but not the tissue around it. In many cases, the MRI system can do this without a contrast injection, which is required in vascular radiology.
Magnetic Intensity The biggest and most important component in an MRI system is the magnet. The magnet in an MRI system is rated using a unit of measure known as a tesla. The magnets in use today in MRI are generally in the 0.5-tesla to 3.0-tesla range.
Prior to allowing a patient or support staff member into the scan room, he or she is thoroughly screened for metal objects. Often however, patients have implants inside them that make it very dangerous for them to be in the presence of a strong magnetic field. People with pacemakers cannot be scanned or even go near the scanner because the magnet can cause the pacemaker to malfunction. Aneurysm clips in the brain can be very dangerous as the magnet can move them, causing them to tear the very artery they were placed on to repair. Some dental implants are magnetic. Most orthopedic implants, even though they may be ferromagnetic, are fine because they are firmly embedded in bone. Even metal staples in most parts of the body are fine -- once they have been in a patient for a few weeks, enough scar tissue has formed to hold them in place. Each time we encounter patients with an implant or metallic object inside their body, we investigate thoroughly to make sure it is safe to scan them. There are no known biological hazards to humans from being exposed to magnetic fields of the strength used in medical imaging today. Most facilities prefer not to image pregnant women. This is due to the fact that there has not been much research done in the area of biological effects on a developing fetus. The decision of whether or not to scan a pregnant patient is made on a case-by-case basis with consultation between the MRI radiologist and the patient's obstetrician. The Magnets There are three basic types of magnets used in MRI systems:
A very uniform, or homogeneous, magnetic field of incredible strength and stability is critical for high-quality imaging. It forms the main magnetic field. Magnets like those described above make this field possible.
Another type of magnet found in every MRI system is called a gradient magnet. There are three gradient magnets inside the MRI machine. These magnets are very, very low strength compared to the main magnetic field; they may range in strength from 180 gauss to 270 gauss, or 18 to 27 millitesla (thousandths of a tesla).
The main magnet immerses the patient in a stable and very intense magnetic field, and the gradient magnets create a variable field. The rest of an MRI system consists of a very powerful computer system, some equipment that allows us to transmit RF (radio frequency) pulses into the patient's body while they are in the scanner, and many other secondary components
Understanding the Technology The MRI machine applies an RF (radio frequency) pulse that is specific only to hydrogen. The system directs the pulse toward the area of the body we want to examine. The pulse causes the protons in that area to absorb the energy required to make them spin, or precess, in a different direction. This is the "resonance" part of MRI. The RF pulse forces them (only the one or two extra unmatched protons per million) to spin at a particular frequency, in a particular direction. The specific frequency of resonance is called the Larmour frequency and is calculated based on the particular tissue being imaged and the strength of the main magnetic field.
These RF pulses are usually applied through a coil. MRI machines come with many different coils designed for different parts of the body: knees, shoulders, wrists, heads, necks and so on. These coils usually conform to the contour of the body part being imaged, or at least reside very close to it during the exam. At approximately the same time, the three gradient magnets jump into the act. They are arranged in such a manner inside the main magnet that when they are turned on and off very rapidly in a specific manner, they alter the main magnetic field on a very local level. What this means is that we can pick exactly which area we want a picture of. In MRI we speak of "slices." Think of a loaf of bread with slices as thin as a few millimeters -- the slices in MRI are that precise. We can "slice" any part of the body in any direction, giving us a huge advantage over any other imaging modality. That also means that you don't have to move for the machine to get an image from a different direction -- the machine can manipulate everything with the gradient magnets.
When the RF pulse is turned off, the hydrogen protons begin to slowly return to their natural alignment within the magnetic field and release their excess stored energy. When they do this, they give off a signal that the coil now picks up and sends to the computer system. What the system receives is mathematical data that is converted into a picture that we can put on film. That is the "imaging" part of MRI.
Most imaging modalities use injectable contrast, or dyes, for certain procedures. MRI is no different.
MRI contrast works by altering the local magnetic field in the tissue being examined. Normal and abnormal tissue will respond differently to this slight alteration, giving us differing signals. These varied signals are transferred to the images, allowing us to visualize many different types of tissue abnormalities and disease processes better than we could without the contrast.
The fact that MRI systems do not use ionizing radiation is a comfort to many patients, as is the fact that MRI contrast materials have a very low incidence of side effects. Another major advantage of MRI is its ability to image in any plane. CT is limited to one plane, the axial plane (in the loaf-of-bread analogy, the axial plane would be how a loaf of bread is normally sliced). An MRI system can create axial images as well as images in the sagitall plane (slicing the bread side-to-side lengthwise) and coronally (think of the layers of a layer cake) or any degree in between, without the patient ever moving. If you have ever had an X-ray, you know that every time they take a different picture, you have to move. The three gradient magnets discussed earlier allow the MRI system to choose exactly where in the body to acquire an image and how the slices are oriented.
Advantages MRI is ideal for:
Disadvantages Although MRI scans are ideal for diagnosing and evaluating a number of conditions, it does have drawbacks as follows:
The Future of MRI The future of MRI seems limited only by our imagination. This technology is still in its infancy, comparatively speaking. It has been in widespread use for less than 20 years (compared with over 100 years for X-rays).
Very small scanners for imaging specific body parts are being developed. Functional brain mapping (scanning a person's brain while he or she is performing a certain physical task such as squeezing a ball, or looking at a particular type of picture) is helping researchers better understand how the brain works. Research is under way in a few institutions to image the ventilation dynamics of the lungs through the use of hyperpolarized helium-3 gas. The development of new, improved ways to image strokes in their earliest stages is ongoing.
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Van Til retains office despite Krieg volleys
By Carrie Napoleon Post-Tribune correspondent November 6, 2012 9:48PM
Lake County surveyor George Van Til (right) listens to updates with supporter Karen Steininger and chief deputy Lake County surveyor Gregory Sanchez as election results come in at Houlihan's in Schererville, Ind. Tuesday November 6, 2012. | Stephanie Dowell~Sun-Times Media
Article Extras
Updated: December 8, 2012 6:21AM
Incumbent George Van Til managed to hold on to the surveyor's position despite an acrimonious campaign with Republican challenger Eric Krieg and an FBI investigation of his office.
In what was likely the most bitter of political battles in Lake County this election, Van Til and Krieg traded barbs about qualifications, commitment and improprieties on a near-daily basis.
Van Til, a Democrat, grabbed an early lead and held on to it throughout the night.
"I am so very grateful for these opportunities to me for public service to do what I love and can do well, to make a real and positive difference for 40 years in this county that has been the Van Til family home for 110 years," Van Til said.
The surveyor said this race was the most negative he has been a part of throughout his political career.
"Irresponsibility and lack of civility or truthfulness has been more evident this year, more than ever before, and it is sad and a disservice to the people we try to serve," he said.
The incumbent surveyor said this will be his last term in office as he looks to leave behind a legacy of public service to the community.
"I will do my best, for as long as I can, to continue to serve the people that have been so good to me for so long and the county I care about so much," Van Til said.
Krieg said the outcome was disappointing but he did do better than most Republicans running in Lake County.
"We did pretty well for a Republican," Krieg said.
Krieg said anger among voters about statements made by Republican Richard Mourdock and lack of support from union labor, which he felt he had more of going into the campaign, hurt his chance.
While he said he was disappointed by the outcome, he does not plan to stop his investigations into how work is being conducted through the Surveyor's Office.
"This is not over with George Van Til. The FBI is still out there … there is more to this. I will be shifting from mere election to what's it going to take to really clean up the Surveyor's Office," Krieg said.


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Black Opal True Color Stick Foundation SPF8 Reviews
Great product!
I love that it hides all of my blemishes, without running or transfeering during social interactions. Very blendable and breathable. — 1 year agoThis review is: Helpful | Not helpful | Inappropriate | 0 of 0 people said helpful
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