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Search Engine
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from a company you can trust
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Search Engine Optimisation, PPC, Conversion Rates; Digital marketing can be a minefield of complex technology and incomprehensible terminology. Hallam Internet clear up the confusion and make it easy for you to understand how you can benefit from adopting Internet Marketing techniques to grow your business.
We work with some of the best companies across the UK, including Experian, the Victoria Centre, Ford, and the Arts Council . We also have specialist experience in B2B sectors including manufacturing, biosciences, as well as B2C sectors including the tourism and leisure sectors.
Our clients benefit from a complete digital marketing service, from developing a new website strategy to benchmarking the performance of a site using Google Analytics, driving organic SEO traffic or PPC traffic, building relationships with email marketing or social media.
Susan Hallam is engaging, impactful, direct and positively challenging to everyone and they all appreciated that on Monday. The fact that the group was so diverse in their understanding and use of digital opportunities would have made the brief to you more challenging, however you handled it really well, thank you!
Kate Fletcher | Vistage
I first attended a training session run by Susan Hallam in 2010 which was so good I've organised Susan to run training for both of the organisations I've worked for since then. Susan is the queen of all things web and social media related. A no nonsense approach that works, without the buzz words and hype.
Fiona Leinster-Evans | Trafford College
We've been absolutely thrilled with the results Hallam Internet has achieved for us over the years. Just 4 months following our new site launch, we have paid for 40% of the total website project in new business directly generated from the work Hallam has done. Nothing is too much for our consultant Ben even if it is not technically his "job description", and I couldn't be happier with what is being produced. I wouldn't hesitate to recommend Hallam Internet to other companies looking to grow their online presence.
Alex Balcombe | Harris Balcombe
We have worked with Hallam over the past 9 months. In this period of time we have seen our company website get on the first page of Google for many of our key search terms. We previously weren't in the top 100 results. The team at Hallam has been very helpful with our overall online strategy. The return on investment has been nothing short of phenomenal. We used to receive 1 or 2 strong leads a month, this has increased to between 8 and 10 strong leads.
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It is a pleasure to work with Hallam Internet. I have found their communication excellent, their response rates are great and they really listen to our requirements.
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We are trusted partner to some of the top brands in the UK, steadily delivering the results they need from their digital marketing. Most of our clients choose to work with us month after month, year after year. A strong working relationship combined with technical expertise is our key to success.
And we're also well respected by our peers. We speak at international industry conferences, write for the national press, and are leading member of the local business community.
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Many of our clients choose to stick with us year after year. You will have your own consultant that you will work with, who knows your business, is dedicated to your account, and is available to talk to you when you want to. We want to delight our customers, and with many of them staying with us for a prolonged period, we know we're delivering great service as well as great results.
We are a company you can trust. Established in 1999, Hallam has been chosen as a supplier by Experian, Ford, the Arts Council, and hundreds of smaller businesses. All of our consultants are top in their field, and we only deliver ethical search marketing services. We are in the industry for the long game, and our clients are, too


text: West Linn's Small Business Resource Center is located in the RAIN (Resources Aiding Innovation and Networking) room of the West Linn Public Library. The room is a space for small business owners and entrepreneurs to work, collaborate and hold meetings. It is open during West Linn Public Library's normal business hours.

subset: commoncrawl


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Featured Companies
Supplier of tree grates, tree guards, bollards and trench grates for the construction and design industry.
Lamboo is an engineered, high performance bamboo product that is used within architectural, structural and design applications, and is structurally superior to its wood counterparts. Lamboo products can be manufactured in both interior and exterior grade and have multiple grain patterns for a variety of aesthetically pleasing options.
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Allred Soffe Wilkinson & Nichols, Inc.
Alpha Precasts (Knecht & Berchtold Inc.)
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Enhance the function and style of your bedroom with handmade, natural solid wood night stands, bedside tables and night tables. Customize your night stand online in a variety of different styles and configurations to find the nightstand that perfectly suits your needs. Then sleep well knowing your night stand is 100% made in America with real, natural sustainably harvested hardwood.
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These vibrant INTENSITY® All Star women's baseball socks keep you comfortably moving at top speed on the field while bringing in-your-face fashion to the game. The ribbed top ensures the socks stay securely in place as you hustle, while compression in the arch delivers dependable support. Cushioning in the heel and toe absorbs impact during harder foot strikes.
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BEACHY KEEN: A chalk-white Dita Von Teese and a deeply tanned Jade Jagger turned up at the Loewe show in Paris on Wednesday. Jagger said she'd just landed in town for the presentation of her new signature clothing and jewelry line today. "There's very much an Ibiza feel to the clothing, with lots of embroidery," said Jagger, flashing a few chunky rings from the line.
BOOK MARK: Those looking for clues to the collaboration between Marc Jacobs and artist Richard Prince for Louis Vuitton had a doozy Wednesday morning. The tent being constructed in the courtyard of the Louvre for Sunday's show boasted a ceiling composed of vintage romance novel covers, all with the words "After Dark" in the title. The book covers are to be papered over with Vuitton's famous monograms.
HEAVEN SCENT: Alexander McQueen has dedicated his show on Friday to his late friend, Isabella Blow, who died in May at age 48. And the colorful fashion director would no doubt have been pleased with the designer's epic, poster-size invitation by illustrator Richard Gray. It depicts a triumphant Blow, in a McQueen dress and a Philip Treacy headdress, in a horse-drawn carriage ascending to heaven.
ALMOND EYES: Eighties icon Marc Almond crawled out of the woodwork at the Jeremy Scott after party at the Elysée Montmartre venue on Tuesday night — and the crowd went wild. Agyness Deyn and her fashion posse, Henry Holland and Gareth Pugh, were among the stage-hangers. Back at the bar, New York DJ act the MisShapes' Leigh Lezark, who appears in the upcoming Roberto Cavalli-H&M campaign, disclosed the group is launching a Web zine later this month. "There will be a lot of fashion content," she said, hinting they're also working on their first fashion collaboration.


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With Bendy: starting afresh. In for a penny, in for a pound. Today's the Day!
Will this mean that Wienerslav will vanish though?
Not with Boston Pirate being MIA.
I have from a Canadian informant word that ESKWeinerslav may be aiding the Mayans further their 12/21/12 end of the world threat.
Last edited by palbert; December 9th, 2012 at 12:39 PM.
Quasar's word from the Just A Kitten thread:
(my emphasis.)And should you wish to re-join in a few months time, I'll be more than happy to reconsider your ban. You'll have more fun IN here, than you will viewing things from the outside.
So we've had EnchantedSexKittenJustaKittenSomeLikeItHot. (Whew, that's a mouthful.) And the month is just ending. When and what next? Be alert!
Are magic amulets at work here?
Last edited by palbert; December 31st, 2012 at 01:47 PM.
^ That will be the end of it.
^^^ I feel it incautious of me to further comment.
And a very happy new year to us all.
We really do need to start a betting pool on the date of our youngun's return.
We should have an "In Memory" thread for all the sock puppets/trolls/billy goats that come along to entertain us in 2013. It saddens me one day we'll have forgotten all about EnchantedSexWaffles
That was so last week.
It took him less than 7 days to melt down (see angry kitty above) and post a shit smeared thread about the JUBBERS he didn't care for.
Resquiat in Pace Puss.
Author of Lost in a Dream. If you want to make me smile, read it and tell me what you think.
Oh, that is so sad. I love cats. This one has been so stressed that his lovable nature is hidden, gone, maybe dead. What happens to living creatures in their lives that so twists them as to make them somethnig they don't really want to be and really shouldn't be?
Are there enough healing arts in the world to go around? JUB alone could use a full-time staff cousellor/psychologist/doctor.
There's plenty of healing and counseling and tinctures to go around. But it's a long rough path from problem to solution, and rarely a simple one. That's why Americans went with a much simpler solution in the early 1980s - we shut down all the "mental hospitals" and so forth. The streets are our psych wards now.
I think he/she was just a pebble on a rocky beach.
I find no user name Angry Sex Kitten. Is that a characterization?


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Freja 950 Small Valandre
Freja 950 Small Valandre: The Freja is a serious bag for 4-season winter use, and perfect for 6000/7000m peaks.
Freja 950 Small Valandre Specs:
- Fabric: Asahi KASEI Impact 66 Polyamide WR Rip-Stop / Asahi KASEI Polyester WR Rip-Stop
- Down Quality: Goose 850+ cuin (US Standards)/Down Load: 33.7oz. (954g.)
- Total Weight: 54.4 oz. (1544 g.)(3 lbs 6 oz)
- Circumference: 62.2/55.9/33.8 Inch (158/142/86cm)
- Length (inside): 66.9 in./170 cm
- Temperature: -34.6F (-37C)
Freja 950 Small Valandre: This little masterpiece - signed Valandré, is quite a conservative bag in its baffle construction. it is "28 straight H box wall construction", fixing the down in independent compartments on the top and on the back. In the field, this offers you the guarantee that once you pull the bag out of the compression sac, the down filling will be exactly where it is designed to be, at the right and precise quantity. (Continuous baffle systems are not advised on a port ledge!).
Freja 950 Small Valandre: The baffles are "tuck stitched" from the inside of the outside fabric, stitching the baffles on to a double layer. Combined with an impressing strong Asahi Kasei fabric, this shell will not fail.....because quality gear are made to last. The zipper is a top quality, 68 inch (175cm), auto-blocking YKK. As the zipper automatically "blocks" in the selected position, the Freja offers an efficient way of regulating the ventilation. And the zipper is protected with a storm flap, to avoid icing of the zip.
Freja 950 Small Valandre: The hood is a perfect 3D "half moon" construction, offering a maximum of down insulation to the extreme forehead, so you can now forget sleeping with your woll hood on. Though very efficient, once drawn down, the hood of the Freja is large enough to offer a possibility of ventilation of the head, once the bag is used in higher temperatures. The draft collar is as perfected as the rest. Basically it's a 3D collar, where the shoulder width is compensated into the shape, hence offering more collars on the shoulders than on the neck and throat, which is calculated within the anatomical shape of the collar. Once again a semi-elastic draw cord is integrated into the collar, offering a precise adjustment and comfort.
In stock items will ship within the next business day. Available item(s) is/are available to order. Most available items will ship within 9 business days, sometimes the process is faster and of course it will ship to you ASAP. There might be some exceptions, example: supplier is out of stock or manufacturing delays. If you have any doubt your item is in stock please call us at 303-984-4649.
For shipping rates and/or international shipping rates and policies, please click here.
If you placed an order at 123Mountain and you don't like it just send it back for a refund, applicable for the item not shipping costs*. Ship it back and as long as your item is in unused condition with original tags, boxes, etc. Please follow the steps at Return Policy Page.
No returns on sale / promotional / discounted item(s).
* Even if the shipping was free we paid the carrier for the service provided and we will deduct $7.95 for Economy, $12.95 for Ground, etc.
Not stoked on your gear? Looking to return it? No problem, we have an Unlimited Return Policy as long as item(s) is/are in UNUSED CONDITION. We try to guarantee complete satisfaction with unlimited lifetime returns. If at any time - now, next month, in 30 years - you're not 100% satisfied, send your gear back for a refund. No questions asked. Check out Return Policy Page here. No returns on sale / promotional / discounted items, though.
PRICE MATCH WARRANTY x 2!
We need your help to always make sure 123Mountain has the best prices! You may even benefit in the process. If you find an identical product at a lower price and in stock through another online site we will refund two times the difference.
Here's how it works:
• Place the order on 123Mountain.com at our current price.
• Email us within 24 hours that you are requesting a price match, including a link to the site where you saw the lower price.
• We will adjust the price and take care of your refund.
For further information please go to 100% SATISFACTION page.
We offer three types of membership; Elite, Premium and Standard. Each membership group has fantastic advantages everything from store credit to an extra 10% OFF and FREE shipping.
Find out more which membership level that fits you the best, click here.


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Brandon Beachy (elbow) threw another bullpen session Friday.
Yankees signed RHP Scott Baker to a minor league contract with an invitation to spring training.
Rockies re-signed RHP Rafael Betancourt to a minor league contract.
Mike Wilner of Sportsnet 590 reports that the Blue Jays' minor league contract with Ronald Belisario has fallen through.
Brewers signed LHP Neal Cotts to a one-year, $3 million contract.
Phillies signed RHP Chad Billingsley to a one-year, $1.5 million contract.
Red Sox and OF Daniel Nava avoided arbitration by agreeing to a one-year, $1.85 million contract.
Jayson Werth will begin serving his five-day jail sentence in Fairfax County, Virginia on Friday.
Brandon Beachy isn't planning to sign with a team until sometime in early- to mid-February.
The Blue Jays have been in contact with the representatives for Francisco Rodriguez, according to Jon Morosi of FOX Sports.
Giants released 2B Marco Scutaro.
Mets and RHP Jenrry Mejia avoided arbitration by agreeing to a one-year, $2.595 million contract.


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1201 K St Sacramento, CA 800.232.7645
Dentists gained firsthand knowledge of practice model selection, contractual analysis, legal implications of claims and more at CDA's Dental Benefits Workshop. Held at CDA's headquarters in Sacramento, more than 70 people, including dentists and staff from 40 practices, attended the March 20-21 event. Attendees were able to earn up to 12 hours of continuing education and improve their skills analyzing and evaluating existing dental plan contract performance in their practices.
Top Stories: Dental benefit bills pass first test; CDA Presents offers tips on improving practices; Sacramento CDA Cares adds premier sponsor
Top Stories: CDA wins Medi-Cal rate court case; Dental team 'on board' for CDA Cares; Guide for New Dentist available on Compass website
Top Stories: CDA sues over Medi-Cal rate cuts; CDA member benefits grow to meet needs; Compass offers tips for marketing dental practices in 2012
Top Stories: Delegates okay Access recommendations; CDA Cares shines light on pro bono work; CDA takes action on dental benefit plans
Top Stories: Ban on fee caps among laws now in effect; Dental society, health center join forces to open clinic; CDA honored for 'vision' in promoting oral health
Top Stories: Governor signs CDA bill on fee caps; Art and Science of Dentistry: CDA Presents provides hands-on look at future; Access issues: Why dentists should pay attention
Top Stories: CDA bill to ban fee caps sent to governor; Precautions urged to prevent spread of pertussis epidemic; CDA studies evidence surrounding access
Top Stories: Dental Board to clarify dental assistant course requirement; State adopts 'timely access to care' regulations; Dental Benefit Plans: Payment dispute? These steps give you power


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The bride is the daughter of Sherry Cranfield of Decatur and the late Douglas McSpadden. She is the granddaughter of Ina McSpadden of Cleveland, the late George McSpadden, and Ray Williams and Hilda Williams, both of Cleveland.
The bridegroom is the son of Edward Fox of Cleveland and Mona Hunt of Ocoee. He is the grandson of Paul Fox and Joyce Fox, both of Cleveland, Melvin Dyer of Varnell, Ga., and the late Annette Dyer.
The wedding was performed by Dr. Edward Williams. The bride was presented in marriage by her uncles, James Burns, Jr., Daniel McSpadden, Roger Brookshire and Ted Selby.
The bride's sister, Amanda McSpadden of Cleveland, was her maid of honor. Bridesmaids were Jamie McSpadden of Charleston, her sister-in-law, and Casey Correia of Cleveland.
The bridegroom's brother Cory Fox of Cleveland was his best man. Groomsmen were David Beck and Tyler McGuire, both of Cleveland.
The reception was held at Black Fox Farms.
After a wedding trip to the Caribbean, the couple is at home in Cleveland.


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Lakegirl84 5pts I must say that I absolutely LOVE my 2013 Altima SV. The color is Pearl White and I think it is such a great looking and great handling car! I actually had a 2013 Metallic Slate Altima that was totaled when a young girl rammed us with her old Honda Civic at a highway off-ramp as we were waiting in traffic. I really can stand behind the safety of the Altima because our two young children (4 and 18 months) were in the back and were somehow unscathed. Altima's are #1 in my book!
Ken H01 5pts Test the 2013's Camary, Altama, Passat, Malibu, and the Accord. FORD NOT even in the competion. Have always been a GM person especially with Trucks. The 2013 Honda Accord should have been the top Car. Our decision after a week of shopping and doing our home work . Overall quality,resale value,comfort and 0.9APR. The Accord Touring V6 was a good choice for me and my wife. This is a very sound car.
ekim3129 5pts I believe the Altima should have 1st place based on my experience with my own. I drove all the others before buying. I got the SL with the works and a 2.5 engine. This car is awesome and with a list price of over 31k I got it out the door for 26.5k with 0% financing! I'm loving it! I've been driving for almost 50 years so maybe that's why I like a great car at a great price!
Continental 5pts Really this segment should have been about: Altima, Optima, Mazda6, Accord, Hyundai and Fusion. Anyways clearly Altima should have been 1st followed by Accord, Fusion and GM.. that's it. Then include the Mazda6 in 2014 segment. People give Mazda's such a hard time. With the most advanced technology, Mazda6 will reign. I've had a few 6's and comparison to the others it's what driving should be -- fun, reliable, sporty and comfy. Toyota or VW can't always be "the" car. I believe Altima and Accord should've been the always picked but needy us has to have a Toyota because everyone has one. ANY car like Crapyota can be reliable if we took care of it and don't drive it hard. It makes sense! I would only buy American cars if they brought back the 3800 V-6's engines that powered the reliable Buick's and build them solid from late 80's to mid 90's. Other than that I'd rather take the bus or bike.
Chad McElravy 5pts I find it very odd that MT trashes the Altima for driving fun, yet it has the best acceleration(check the numbers) of any of them, while achieving best MPG. I do agree with the velour on the seats(terrible), you must get the leather. The rest of the interior is spectacular!
ssoeun02 5pts Based on the data shown, I will pick Accord and Altima as the first and second places respectively. Because power and fuel economy are the most important for me. Accord and Altima get from 0 to 60m/h in just 7.7 seconds and have the best fuel economy in their class 27/38 Altima and 27/36 Accord, and I have no doubt about good quality of these two. But the Malibu deserves its place. I'm not convinced yet about the reliability of the turbo engine Fusion. Ford has no record making a good turbo engine like BM and VW. The fuel economy and power has kept me away from the Passat showroom. It should get better mileage than this to attrack more fans, 22/31 even worst than Accord V6, 278 hp get 21/34.
TeamWidetrack 5pts I'm actually thrilled that the '013 Malibu lost.....badly. GM did too many things wrong with it, starting with eliminating the V6 option and putting an inconvenient, useless rocker switch ON TOP of the shifter as the manumatic. Dan Akerson pushed this car's debut up six months just to beat the Fusion to market and this car would go on to get beaten by pretty much every other car in the segment. This car as it stands is such a huge disappointment that even rental car companies deserve better than this. It's slogan should be "A third-rate midsize sedan from a third-rate CEO who knows nothing about cars." Or maybe that is too long? Either way, this highlights an ongoing problem with GM's many CEOs: they don't put half the effort into making great cars as they do promoting themselves.
olmster 5pts The biggest problem that I have with this comparison of vehicles is that there is a considerable difference in features and price among the vehicles being compared. The article states that the vehicles were ordered this way so it was not a case of vehicle availability that sometimes occurs with these comparison tests. If one has leather seats they should all have leather seats. A four door sedan consumer is not going to be realistically choosing between a $32,360 and $25,720 vehicle. (A 25% difference in price, not going to happen). The Ford Fusion could have been outfitted with the 2.0 Turbo and still be below the price of three of these vehicles. Comparing apples to apples is a difficult task when it comes to vehicles but this comparison could have provided a better analysis for your readers if the chosen vehicles had been more similar in features and price. Real buyers don't have cars given to them so price is a major determining factor.
Black Dynamite 5pts Malibu: A lost causeCamry: Interior is cut rate, but it has an efficient drivetrain and good roomAltima: Their CVT is love it or hate it. Looks more like a Maxima now.Fusion: Cut costs on the interior. You can have any color you want, as long as it's blackAccord: Probably the best car herePassat: Makes the Camry look sexy and stylish. The engine is so old and feeble, it should come with a crankBD
buyingconstant7 5pts Oh I'm sorry you Japanese and American car fan ***! MotorTrend picked this car for the Car of the Year 2012 and all the mid size comparo champion because its an amazing car! 95% of you havent driven one and stop bashing the car since you drive a Civic or Corolla and think that brand should win!
David Sivertsen-Neale 5pts Well... Car & Driver placed the Passat SE 4th out of 4, with the Accord as 1st, so you guys all need to go out for coffee or beers together now. :)
firstname.lastname@example.com 5pts I valet park cars for a living and have had a chance to park all of these cars except the 2013 Ford Fusion. I can find faults in all of them and also good parts to them. But I respect MT for their decision since they drive the cars for hundreds of miles and through different types of circumstances, while I just drive it for a few hundred yards. Here are my pro & cons:Chevrolet Malibu = + comfortable ride / - rear stylingFord Fusion (2012 or older) = + steering feel / - rental car interior qualityHonda Accord = + huge rear seat / - copy cat styling cuesNissan Altima = + I could not find anything good / - keyless key fob (you can drive away without key in car) & feels cheap inside tooToyota Camry = + much improved interior over previous generation / - absolutely no brake feel (touchy brakes)Volkwagen Passat = + best ergonomics & one touch up & down for all windows / - the most boaring interior of all
Vince Ng 5pts Passat the winner? Seriously? It scored the lowest 0-60 mph, old 2.5L I5 engine that sounds thrashy, questionable reliability and average mph....seriously, how much VW is paying you guys? IMO, the list should be as follow:1.Honda Accord2.Nissan Altima3.Ford Fusion4.VW Passat5.Toyota Camry6.Chevy Malibu
Christopher Lee 5pts Ok, I can see the title is the "Battle of the BEST SELLERS" but come on, no Mazda 6..... again!?!?! What the hell? You already have 6 cars, you can't do one more? I am a huge VW fan, but not including the Mazda 6 again for the 3-4th time in a row is a real shame and almost tells me that you're afraid to run it up against these cars. I just don't understand it.
Brian Rokosz 5pts For the past 2 years I've worked at an autopark in Urbana, IL that sells the Sonata, Optima, Camry, and Passat and have compared all of these in each engine choice...based on BASE model alone I'd choose the Optima, the Fully Loaded goes to the Passat, but that's with the V6...and still the Optima comes close (it would win if not for the sport tuned suspension which a Passat buyer wouldn't really like)...the Camry is really cheap feeling inside and the plastic is worse than the 2007 version I currently own....as for the Accord and Fusion...wow...I gotta say if I was picking a car today, it would be between those...HUGE improvements...choosing from Fusion 1.6L Ecoboost SE ($25,440) vs Accord Sport 2.5L ($24,900) I'd say the exterior of the Fusion needs to be seen in person to really get how rich it looks. The Accord's interior though (on the Sport) is probably the nicest sub-30k car I've ever sat in...Passat though...ya no, very plain interior...Lets put it this way..before the Accord Sport, my dad would be getting the Passat TDI and I'd be buying the Optima...now...I'd flip for who gets the Accord and who gets the Fusion
MotorCityRocker 5pts To Ray1340: Unless you're a kid or just don't know any better, VW has been selling cars in the United States for over 60 years. I don't expect them to die off anytime soon. They have some great cars presently, and more on the way. I'm not sure what reliability problems you're talking about? All auto manufacturers have had some problems here and there in their history, just look at the crap Toyota puts out! Isn't thar right BlackDynomite?
Ray1340 5pts After reading some of the comments I can only say that time will tell if VW fix their reliability issues, if not the company will die in America because right now the have a lot of customers and if these people are not happy they won't buy another VW ever again and the sales numbers will crash for VW.
CJinSD 5pts Motor Trend recently held a comparison test of all three engine variants of the Korean twins, the Camry, and the Passat. The Hyundai/Kia was worst in every category, lacking in performance and efficiency relative to the equivalent Camry 4 cylinder, hybrid and V6. The turbo Sonata was barely quicker than the hybrid Camry while using 10% more fuel than the V6 Camry that was 1.2 seconds quicker to 60 mph. The Passat was picked as winner in all classes with their I5, diesel, and VR6, but that increasingly looks bought. What gets me is that the Camry was 2nd in each category and received quite a bit of praise only to be panned in this competition. Motor Trend doesn't seem to think much of its readers.
Coldgame76 5pts CarAndDriver rated #1 Honda Accord#2 Ford Fusion#3 Nissan Altima#4 VW Passat.I think their rating is a lot more accurate than Motortrend's
midmac 5pts I cannot go with a VW product until they have long term reliability like the other participants and Hyundai/Kia. My son just had to sell his A4, which was coming off VW's short warranty because it was having the same engine control issues that my Audi had 15 years ago.
Black Dynamite 5pts It's pretty clear MT is on the VW payroll. If you didn't know after last year, now you know.....BD
joao pinto 5pts Im from europe,portugal,and here everyone buys german,mostly vw,they think they are upper status because of that,show offs. All magazines every week reviews 7 -8 german cars out of 10..what they dont tell you,is that they breakdown a lot,even 1year cars,,and regular maintenance is very expensive,(dsg gearbox needs regular expensive care). I have 20years old japanese car,always hardriving/trashing, just change oil,and its good to go. You say vw is new??completly ignorant, check the lights switch,the same as a 1989 golf! Doors close good? change the rubbers from the door. Iron block engine, wtf in the 21century?? dont be fooled. Just like europe,vw must be paying you a lot to write this reviews.
jimmy999 5pts Over here on the east coast, the smart money only goes for Toyota or Honda. Perhaps a Nissan. The Detroit stuff is unreliable junk. And, these message boards are full of Detroit operatives posting their pro GM ... pro Ford bull.
mdean60 5pts Why in blue blazes didn't you include the Hyundai Sonata in these tests? I bought a 2013 (traded in a 2005 Sonata) and it surpasses in every category the traits described here for the other makes! (especially mileage)MDean
Black Dynamite 5pts Americans don't buy Passats because they are about as trustworthy as Mitt Romney.MT can hand it all the wins it doesn't deserve. Doesn't change a thing. They sold less than 10k last month.....BD
gmokeg 5pts can not believe vw won, had gold tdi and was in the shop six months no fix, no customer support all documented......
nmonaco3 5pts The 2013 Fusion should of won this 100%!!First of all with an average Price As Tested of $28.6K, why was the Fusion that was tested a $26K SE w/Stick and No Options?!For $28.6K your could of tested a Fusion SE Automatic with the Luxury package (Heated Leather Seats + More) & Technology Package (8" Touch Screen & Dual Zone Auto Climate Control + More) & a Sunroof!!It would of blown everyone away with that interior if you are trying to compare apples to apples. This comparo is a joke MT..
heymatey 5pts Had high hopes for the Fusion, but even with a manual transmission, its 1.6l EcoBoost had lower performance and efficiency than most of the competition's automatics! I wonder how the carry-over 2.5l will work in this application.
BrunoT 5pts Hey, johnson1, they make Kia's about an hour and a half from my house. They BMW's in SC. Toyotas, Nissans, you name it. And many of these companies are public. Americans own shares too.
BrunoT 5pts Why did the Ford not win again? Quicker, better handling, better looking? Was it just the interior? I guess as a family hauler the Passat could have an edge, but certainly boring to look at and it's harder to write monthly checks for a car you don't love.
Mike Kraine 5pts I recommended an earlier generation Passat to my sister and it was the biggest piece of junk I've ever seen. She had a ton of electrical problems. It kept breaking down on the side of the highway putting her at risk. A complete nightmare. I really like the design of VWs but will never buy or could I in good faith, recommend one.
Griddle 5pts I'm going to agree with some of the others here...1.) The KIA Optima should have been included here. It's a solid performer, best warranty, and looks better than almost every car tested. (The Sonata and Mazda6 would have been good to.)2.) The interior of the Malibu DOES look ridiculous. There is FAKE WOOD on the STEERING WHEEL! Why, GM? Why? The outside of the car looks like it wants to be a Camaro, and the inside looks like it wants to be Grandpa's Buick Le Sabre. Chrome and fake wood everywhere! Disgusting. GM needs to look more closely at VW/Audi to understand what a tasteful interior looks like.3.) I don't care how good of a car the Passat is, it's THE most boring-looking sedan on the road. No other new car looks this boring. In fact, the design would have been boring had it come out in 2000. Dull, dull, dull.4.) The Ford Fusion looks really interesting to me. I like the British-style design and it sounds like a real driver's car. The SVT Fusion should be an AMAZING car. Can't wait.Read more
andyoo 5pts VW sucks. make in mexico or brazil. my wife's last golf has so much electronic problem it stays at the shop most of the time.the soft plastic material on knobs peels off and engin check light is on and off all the time. light blubs at the back brake light all died within 2 year...I have my acura for 6yrs and yet to change one bulb... cheap parts and cheap labor...all it's left is german engineering which don't do much to thoe junk.
Mezza Dave 5pts You guys kill me. 1.1 seconds slower 0-60 when compared to the Honda is more than significant. Only you guys can praise a car that had content removed as being better without the content. VW has been unable to prove they can build reliable cars and the dealers in my area always have a large inventory. That proves the people who actually buy cars know Honda rules. If you ever get over your German bias, so will you.
GRAYWOLF69 5pts Hmmm, no 200/Avenger, no Optima/Sonata, no Galant, no Imprezza...half-assed comparison!
Black Dynamite 5pts I wonder why Ford can't get more than 20% domestic content into the Fusion.http://www.caranddriver.com/features/a-graphic-representation-of-whats-really-made-in-america-featureWhat's up with that? Americans make car parts too!BD
wadeblakey 5pts I am not sure how you can compare $25,000 cars with $32,000 models and compare a manual with automatics. You should either set a "standard" price target for comparisons or you should set a "standard" model/trim level for them. Also, I drove the new 2013 Accord (4 and 6 cyl models), Malibu and Altima. The Accord was unacceptably noisy - engine, wind and road (very dissapointed in this as Honda states they did all kind of things to make it quieter - they failed). The Malibu seemed the quitest and the Altima the most fun to drive. I am waiting for the 2013 Fusion to arrive at the dealers to test drive it.
Chris Skalski 5pts @Continental Yes, I have one of the Optima's. I am constantly being approached at gas stations, Walmart, the grocery store, etc by people who love how my car looks. It is a Spicy red EX model with the 200 HP 2.4 liter 4, which is the most powerful base engine in the entire mid size sedan lineup, save for it's sister car, the Hyundai Sonata. With (real) leather, fog lights, dual zone climate control, dual exhaust, blue-tooth, USB, Sirius, Pandora, refrigerated glove box, rear A/C vents, and 35/24 mpg I paid $21,880. It stickered for $24,260. Also, it has a 10 year, 100 k warranty. My ONLY competition (IMO) is the 2014 Mazda 6. Nuff said. Also, I have no idea why ANYONE would want to buy a 5cyl Passat (they are discontinuing that engine... NOW!) with only a 3 year warranty, and only 170 HP. My engine makes 30 more HP. VW's are great until it breaks down and it's $500 for a $30 power window motor.
jshaw31 5pts @Black Dynamite Motortrend chose one thing, and the ONLY thing, VW did slightly better than the accord, and knocked it down. Yet, it ignored most other sites rating the Fusion above the Passat, why? At any rate, they are just looking to justify their Passat COTY award from last year. At any rate, I adblock this site, just for the heck of it. At least they haven't reached Consumer Reports levels of arrogance, yet. But they are inching there.
JBaustian 5pts @midmac Something must be wrong with my '03 Golf with 403k miles, because it doesn't have this reliability problem you refer to.
Elliott Ridge 5pts @Black Dynamite We get it: you hate the Passat. Ad nauseum. Find a new hobby. Sheesh...
JBaustian 5pts @andyoo All Golfs sold in the US and Canada since 2003 or 2004 have been built in Germany. I got one of the last ones from Brazil (and it's been a great car).
email@example.com 5pts @jshaw31 @Black Dynamite I find it funny that Car and Driver's review put the passat 4th behind the altima, fusion and honda. Then again the have a huge crush on the accord. I like the fusion personally. "best steering", "sportiest car". Best looking. Quite. But regardless, I like the fusion, accord and altima more than the passat. And I like the new mazda6 most of all. Those 4 are definitely all solid choices in the midsize market. Too bad the mazda6 is doing so poorly in sales along with the rest of mazda this month. I still think the 3 is the best compact as well.


text:
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Pousada Galeria Artes的到达路线
From the bus station:
Walk up three blocks to the main street (Rua Cel. Pilad Rebu�). Turn left into the main street and walk up-town until you see the sign Projeto Jiboia (Boa Project). Turn right into Rua Nestor Fernandes, pass the Boa Project on your left until you reach the next crossing (Rua Luiz da Costa Leite).
Turn left into Rua Luiz da Costa Leite. No 1053, Pousada Galeria Artes, is opposite. The overall distance from the bus station is about 500m.


text:
Toronto Police Traffic Services has made it really easy to file complaints about bad behaviour by drivers. You can now submit the complaint via email by following this link;
It opens as a PDF and you should be able to email it right from your desktop. Make sure you read all of the cautions. Key is that you are able to identify the driver. The police are under no obligation to take any action with respect to your report. Never embellish your reports. You do not need to name the section of the HTA you claim the driver violated.
What if I cannot identify the driver? It may be worthwhile still sending the report but ensure you indicate that you are not able to identify the driver. It may be helpful in the case of a serial bad driver. Do keep a copy of what you sent in. Same goes for any notes you took.
If you have been hit on the road or your life threatened do not wait to get home to file a report. CALL 911 as soon as it is safe to do so.


text:
Featured Research
What can we learn by studying exercise and Parkinson's? PDF-funded researcher Kristen Pickett, Ph.D., is using magnetic resonance imaging to help find answers to improve life for people with PD.
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Are you interested in furthering Parkinson's science? View PDF's open grant programs.
Genetics and PD
PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research.
Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members? Please browse PDF's educational materials and programs - which are all available electronically or in print. Order for yourself, a loved one or in bulk for your patients or support group.
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USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
Christian N Cunningham, Joshua M Baughman, Lilian Phu, Joy S Tea, Christine Yu, Mary Coons, Donald S Kirkpatrick, Baris Bingol, Jacob E Corn
Nat Cell Biol 2015 Jan;
PMID: 25621951 [PubMed - as supplied by publisher]
Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis.
Alberto Capurro, Liviu-Gabriel Bodea, Patrick Schaefer, Ruth Luthi-Carter, Victoria M Perreau
Front Neurosci 2014 ; 8:441
PMID: 25620908 [PubMed - as supplied by publisher]
An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene-environment interactions.
Michaela E Johnson, Larisa Bobrovskaya
Neurotoxicology 2014 Dec; 46C:101-116
PMID: 25514659 [PubMed - as supplied by publisher]
An association analysis of the R1628P and G2385R polymorphisms of the LRRK2 gene in multiple system atrophy in a Chinese population.
XiaoQin Yuan, YongPing Chen, Bei Cao, Bi Zhao, QianQian Wei, XiaoYan Guo, Yuan Yang, LiXing Yuan, HuiFang Shang
Parkinsonism Relat Disord 2015 Feb; 21(2):147-149
PMID: 25511328 [PubMed - as supplied by publisher]
Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Qi Shi, Li-Na Chen, Bao-Yun Zhang, Kang Xiao, Wei Zhou, Cao Chen, Xiao-Mei Zhang, Chan Tian, Chen Gao, Jing Wang, Jun Han, Xiao-Ping Dong
Mol Cell Proteomics 2015 Jan;
PMID: 25616867 [PubMed - as supplied by publisher]
Amyloid ? oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
Kirsten L Viola, William L Klein
Acta Neuropathol 2015 Feb; 129(2):183-206
PMID: 25604547 [PubMed - as supplied by publisher]
Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.
James M Gruschus, Zhiping Jiang, Thai Leong Yap, Stephanie A Hill, Alexander Grishaev, Grzegorz Piszczek, Ellen Sidransky, Jennifer C Lee
Biochem Biophys Res Commun 2015 Jan;
PMID: 25600808 [PubMed - as supplied by publisher]
The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway.
Feng Gao, Dong Chen, Jianmin Si, Qingsong Hu, Zhenghong Qin, Ming Fang, Guanghui Wang
Hum Mol Genet 2015 Jan;
PMID: 25612572 [PubMed - as supplied by publisher]
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease.
Alicia M Pickrell, Richard J Youle
Neuron 2015 Jan; 85(2):257-273
PMID: 25611507 [PubMed - as supplied by publisher]
A53T Human ?-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration.
Linan Chen, Zhiguo Xie, Susie Turkson, Xiaoxi Zhuang
J Neurosci 2015 Jan; 35(3):890-905
PMID: 25609609 [PubMed - as supplied by publisher]
Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Jing Yan, Ahmad Almilaji, Evi Schmid, Bernat Elvira, Derya R Shimshek, Herman van der Putten, Carsten A Wagner, Ekaterina Shumilina, Florian Lang
FASEB J 2015 Jan;
PMID: 25609428 [PubMed - as supplied by publisher]
PINK1- and PARK2-mediated local mitophagy in distal neuronal axons.
Ghazaleh Ashrafi, Thomas L Schwarz
Autophagy 2015 Jan; :0
PMID: 25607607 [PubMed - as supplied by publisher]
The reduction of vascular disease risk mutations contributes to longevity in the Chinese population.
Yong-Han He, Xiang Lu, Ming-Xin Bi, Li-Qin Yang, Liang-You Xu, Qing-Peng Kong
Meta Gene 2014 Dec; 2:761-8
PMID: 25606459 [PubMed - as supplied by publisher]
An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.
Hye Jin Yun, Hyejung Kim, Inhwa Ga, Hakjin Oh, Dong Hwan Ho, Jiyoung Kim, Hyemyung Seo, Ilhong Son, Wongi Seol
J Biochem 2015 Jan;
PMID: 25605758 [PubMed - as supplied by publisher]
Rare variants in ?-Amyloid precursor protein (APP) and Parkinson's disease.
Eva C Schulte, Akio Fukumori, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael HŘll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas BrŘcke, Benjamin Bereznai, Maria J Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters, Christian Gieger, Xavier Estivill, Thomas Meitinger, Hans A Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelmann
Eur J Hum Genet 2015 Jan;
PMID: 25604855 [PubMed - as supplied by publisher]
Head injury, potential interaction with genes, and risk for Parkinson's disease.
Jianjun Gao, Rui Liu, Edward Zhao, Xuemei Huang, Michael A Nalls, Andrew B Singleton, Honglei Chen
Parkinsonism Relat Disord 2015 Jan;
PMID: 25603768 [PubMed - as supplied by publisher]
CHIP is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Amy Marie Palubinsky, Jeannette Nicole Stankowski, Alixandra Cozette Kale, Simona G Codreanu, Robert J Singer, Daniel C Liebler, Gregg D Stanwood, BethAnn Marie McLaughlin
Antioxid Redox Signal 2015 Jan;
PMID: 25602369 [PubMed - as supplied by publisher]
Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.
C L Bethea, A P Reddy
Mol Psychiatry 2015 Jan;
PMID: 25600110 [PubMed - as supplied by publisher]
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Anke Van der Perren, Jaan Toelen, Cindy Casteels, Francesca Macchi, Anne-Sophie Van Rompuy, Sophie Sarre, Nicolas Casadei, Silke Nuber, Uwe Himmelreich, Maria Isabel Osorio Garcia, Yvette Michotte, Rudi D'Hooge, Guy Bormans, Koen Van Laere, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2014 Dec;
PMID: 25599874 [PubMed - as supplied by publisher]
Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle.
S Pablo Sardi, Seng H Cheng, Lamya S Shihabuddin
Prog Neurobiol 2015 Jan;
PMID: 25573151 [PubMed - as supplied by publisher]
Canonical Wnt Signaling Regulates Atrioventricular Junction Programming and Electrophysiological Properties.
Benjamin S Gillers, Aditi Chiplunkar, Haytham Aly, Tomas Valenta, Konrad Basler, Vincent M Christoffels, Igor R Efimov, Bastiaan J Boukens, Stacey Rentschler
Circ Res 2014 Nov;
PMID: 25599332 [PubMed - as supplied by publisher]
The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.
Gerwyn Morris, Michael Berk, Piotr Galecki, Ken Walder, Michael Maes
Mol Neurobiol 2015 Jan;
PMID: 25598355 [PubMed - as supplied by publisher]
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.
Yu Tang, Weidong Le
Mol Neurobiol 2015 Jan;
PMID: 25598354 [PubMed - as supplied by publisher]
Purine metabolism gene deregulation in Parkinson's disease.
Paula Garcia-Esparcia, Karina Hernßndez-Ortega, BelÚn Ansoleaga, Margarita Carmona, Isidre Ferrer
Neuropathol Appl Neurobiol 2015 Jan;
PMID: 25597950 [PubMed - as supplied by publisher]
Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acid in U373MG human astrocytoma cells.
Tadaatsu Imaizumi, Nina Sakashita, Yasuaki Mushiga, Hidemi Yoshida, Ryo Hayakari, Fei Xing, Liang Wang, Tomoh Matsumiya, Kunikazu Tanji, Yuki Chiba, Ken Furudate, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka
Neurosci Res 2015 Jan;
PMID: 25591911 [PubMed - as supplied by publisher]
The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: Possible significance in the transgenic model mouse of Parkinson's disease.
T Miyajima, E Ohta, H Kawada, T Maekawa, F Obata
Neurosci Lett 2015 Jan; 588C:142-146
PMID: 25562633 [PubMed - as supplied by publisher]
Possible involvement of iron-induced oxidative insults in neurodegeneration.
Takeshi Asano, Masato Koike, Shin-Ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai
Neurosci Lett 2014 Dec; 588C:29-35
PMID: 25549542 [PubMed - as supplied by publisher]
Therapeutic strategies in Parkinson's disease: what we have learned from animal models.
Jorge S Valadas, Melissa Vos, Patrik Verstreken
Ann N Y Acad Sci 2014 Dec;
PMID: 25515068 [PubMed - as supplied by publisher]
CSF tau and tau/A?42 predict cognitive decline in Parkinson's disease.
Changqin Liu, Brenna Cholerton, Min Shi, Carmen Ginghina, Kevin C Cain, Peggy Auinger, , Jing Zhang
Parkinsonism Relat Disord 2015 Jan;
PMID: 25596881 [PubMed - as supplied by publisher]
Overexpression of blood microRNAs 103a, 30b, and 29a in l-dopa-treated patients with PD.
Alice Serafin, Luisa Foco, Stefano Zanigni, Hagen Blankenburg, Anne Picard, Alessandra Zanon, Giulia Giannini, Irene Pichler, Maurizio F Facheris, Pietro Cortelli, Peter P Pramstaller, Andrew A Hicks, Francisco S Domingues, Christine Schwienbacher
Neurology 2015 Jan;
PMID: 25596505 [PubMed - as supplied by publisher]
COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese.
Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu
Mov Disord 2015 Jan;
PMID: 25594503 [PubMed - as supplied by publisher]
Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
Erik Cederfjńll, Lauren Broom, Deniz Kirik
Mol Ther 2015 Jan;
PMID: 25592335 [PubMed - as supplied by publisher]
Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns.
Kenneth K B Tan, Jason Y Tann, Sharvari R Sathe, Seok Hong Goh, Dongliang Ma, Eyleen L K Goh, Evelyn K F Yim
Biomaterials 2015 Mar; 43:32-43
PMID: 25591959 [PubMed - as supplied by publisher]
Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-? hydroxysteroid dehydrogenase type 10.
G Bertolin, M Jacoupy, S Traver, R Ferrando-Miguel, T Saint Georges, K Grenier, H Ardila-Osorio, M-P Muriel, H Takahashi, A J Lees, C Gautier, D Guedin, F Coge, E A Fon, A Brice, O Corti
Cell Death Differ 2015 Jan;
PMID: 25591737 [PubMed - as supplied by publisher]
A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes.
N K Magdalinou, R W Paterson, J M Schott, N C Fox, C Mummery, K Blennow, K Bhatia, H R Morris, P Giunti, T T Warner, R de Silva, A J Lees, H Zetterberg
J Neurol Neurosurg Psychiatry 2015 Jan;
PMID: 25589779 [PubMed - as supplied by publisher]
Role of ?-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease.
Heather E Allen Reish, David G Standaert
J Parkinsons Dis 2015 Jan;
PMID: 25588354 [PubMed - as supplied by publisher]
STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
Pradeep K Kurup, Jian Xu, Rita Alexandra Videira, Chimezie Ononenyi, Graša Baltazar, Paul J Lombroso, Angus C Nairn
Proc Natl Acad Sci U S A 2015 Jan;
PMID: 25583483 [PubMed - as supplied by publisher]
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Anne Vital, Sebastien Lepreux, Claude Vital
J Peripher Nerv Syst 2015 Jan;
PMID: 25582874 [PubMed - as supplied by publisher]
Comprehensive Analysis of the Mouse Brain Proteome Sampled in Mass Spectrometry Imaging.
Bram Heijs, Ricardo J Carreira, Else A Tolner, Arnoud H de Ru, Arn M J M van den Maagdenberg, Peter A van Veelen, Liam A McDonnell
Anal Chem 2015 Jan;
PMID: 25535922 [PubMed - as supplied by publisher]
Alpha-synuclein biology in Lewy body diseases.
Woojin Scott Kim, Katarina Kňgedal, Glenda M Halliday
Alzheimers Res Ther 2014 ; 6(5):73
PMID: 25580161 [PubMed - as supplied by publisher]
Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis.
Yongdui Chen, Siqi Li, Liling Su, Jinghao Sheng, Wen Lv, Guangdi Chen, Zhengping Xu
J Neurol 2015 Jan;
PMID: 25578179 [PubMed - as supplied by publisher]
Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.
Sophie E Winder-Rhodes, Adam Hampshire, James B Rowe, Jonathan E Peelle, Trevor W Robbins, Adrian M Owen, Roger A Barker
Neurobiol Aging 2014 Dec;
PMID: 25577413 [PubMed - as supplied by publisher]
A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia.
Jun-Ichi Satoh, Naohiro Asahina, Shouta Kitano, Yoshihiro Kino
Gene Regul Syst Bio 2014 ; 8:127-39
PMID: 25574134 [PubMed - as supplied by publisher]
Discovery of functional non-coding conserved regions in the ?-synuclein gene locus.
Lori Sterling, Michael Walter, Dennis Ting, Birgitt SchŘle
F1000Res 2014 ; 3:259
PMID: 25566351 [PubMed - as supplied by publisher]
Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on ?-Synuclein.
Nripesh Dhungel, Simona Eleuteri, Ling-Bo Li, Nicholas J Kramer, Justin W Chartron, Brian Spencer, Kori Kosberg, Jerel Adam Fields, Klodjan Stafa, Anthony Adame, Hilal Lashuel, Judith Frydman, Kang Shen, Eliezer Masliah, Aaron D Gitler
Neuron 2015 Jan; 85(1):76-87
PMID: 25533483 [PubMed - as supplied by publisher]
Application of next-generation sequencing technologies in Neurology.
Teng Jiang, Meng-Shan Tan, Lan Tan, Jin-Tai Yu
Ann Transl Med 2014 Dec; 2(12):125
PMID: 25568878 [PubMed - as supplied by publisher]
Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.
Fanny Charbonnier-Beaupel, Marion Malerbi, Cristina Alcacer, Khadija Tahiri, Wassila Carpentier, Chuansong Wang, Matthew During, Desheng Xu, Paul F Worley, Jean-Antoine Girault, Denis HervÚ, Jean-Christophe Corvol
J Neurosci 2015 Jan; 35(1):96-111
PMID: 25568106 [PubMed - as supplied by publisher]
Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data.
Kathrin Reetz, Imis Dogan, Ana S Costa, Manuel Dafotakis, Kathrin Fedosov, Paola Giunti, Michael H Parkinson, Mary G Sweeney, Caterina Mariotti, Marta Panzeri, Lorenzo Nanetti, Javier Arpa, Irene Sanz-Gallego, Alexandra Durr, Perrine Charles, Sylvia Boesch, Wolfgang Nachbauer, Thomas Klopstock, Ivan Karin, Chantal Depondt, Jennifer MŘller Vom Hagen, Ludger Sch÷ls, Ilaria A Giordano, Thomas Klockgether, Katrin BŘrk, Massimo Pandolfo, J÷rg B Schulz
Lancet Neurol 2015 Jan;
PMID: 25566998 [PubMed - as supplied by publisher]
Parkinson's disease: animal models and dopaminergic cell vulnerability.
Javier Blesa, Serge Przedborski
Front Neuroanat 2014 ; 8:155
PMID: 25565980 [PubMed - as supplied by publisher]
PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane.
Stephan Gehrke, Zhihao Wu, Michael Klinkenberg, Yaping Sun, Georg Auburger, Su Guo, Bingwei Lu
Cell Metab 2015 Jan; 21(1):95-108
PMID: 25565208 [PubMed - as supplied by publisher]
Association of MTHFR C677T with total homocysteine plasma levels and susceptibility to Parkinson's disease: a meta-analysis.
Ying Zhu, Rui-Xia Zhu, Zhi-Yi He, Xu Liu, He-Nan Liu
Neurol Sci 2015 Jan;
PMID: 25564416 [PubMed - as supplied by publisher]
Fluorescence quenched substrates for live cell imaging of human glucocerebrosidase activity.
Anuj K Yadav, David Shen, Xiaoyang Shan, Xu He, Allison R Kermode, David J Vocadlo
J Am Chem Soc 2015 Jan;
PMID: 25562638 [PubMed - as supplied by publisher]
Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease.
Abhimanyu Krishna, Maria Biryukov, Christophe Trefois, Paul Ma Antony, Rene Hussong, Jake Lin, Merja Heinńniemi, Gustavo Glusman, Sandra K÷glsberger, Olga Boyd, Bart Hj van den Berg, Dennis Linke, David Huang, Kai Wang, Leroy Hood, Andreas Tholey, Reinhard Schneider, David J Galas, Rudi Balling, Patrick May
BMC Genomics 2014 ; 15:1154
PMID: 25528190 [PubMed - as supplied by publisher]
Beyond Mitophagy: Cytosolic PINK1 as a messenger of mitochondrial health.
Erin K Steer, Michelle K Dail, Charleen T Chu
Antioxid Redox Signal 2015 Jan;
PMID: 25557302 [PubMed - as supplied by publisher]
PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation.
Boram Min, Young-Chang Kwon, Kwang-Min Choe, Kwang Chul Chung
J Neurosci Res 2014 Dec;
PMID: 25557247 [PubMed - as supplied by publisher]
The link between the SNCA gene and parkinsonism.
Wei Xu, Lan Tan, Jin-Tai Yu
Neurobiol Aging 2014 Dec;
PMID: 25554495 [PubMed - as supplied by publisher]
Epigenetic mechanisms in Parkinson's disease.
Ya Feng, Joseph Jankovic, Yun-Cheng Wu
J Neurol Sci 2014 Dec;
PMID: 25553963 [PubMed - as supplied by publisher]
Functions and characteristics of PINK1 and Parkin in cancer.
Satoru Matsuda, Atsuko Nakanishi, Akari Minami, Yoko Wada, Yasuko Kitagishi
Front Biosci (Landmark Ed) 2015 ; 20:491-501
PMID: 25553463 [PubMed - as supplied by publisher]
Lipid rafts involvement in the pathogenesis of Parkinson's disease.
Shin-Ichiro Kubo, Taku Hatano, Nobutaka Hattori
Front Biosci (Landmark Ed) 2015 ; 20:263-79
PMID: 25553450 [PubMed - as supplied by publisher]
Exploring determinants of progression in Parkinson's disease. Is there a difference among Jewish ethnic groups?
Y Orlev, G Yahalom, O S Cohen, S Elincx-Benizri, E Kozlova, R Inzelberg, U Goldbourt, S Hassin-Baer
Parkinsonism Relat Disord 2014 Oct;
PMID: 25550275 [PubMed - as supplied by publisher]
Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M Griggs, Laura Zavala-Flores, Elsa M Reyes-Reyes, Javier Seravalli, Lia A Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franco
Neurobiol Dis 2014 Dec;
PMID: 25497688 [PubMed - as supplied by publisher]
ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter ?-Synuclein Metabolism in SH-SY5Y Cells.
Eun-Jin Bae, Cheolsoon Lee, He-Jin Lee, Seokjoong Kim, Seung-Jae Lee
Exp Neurobiol 2014 Dec; 23(4):365-71
PMID: 25548536 [PubMed - as supplied by publisher]
Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes.
Ji-Young Han, Ji-Soo Kim, Jin H Son
Exp Neurobiol 2014 Dec; 23(4):345-51
PMID: 25548534 [PubMed - as supplied by publisher]
ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.
Tomßs Lopes da Fonseca, Tiago Fleming Outeiro
Exp Neurobiol 2014 Dec; 23(4):314-23
PMID: 25548531 [PubMed - as supplied by publisher]
Alpha-synuclein function and dysfunction on cellular membranes.
David Snead, David Eliezer
Exp Neurobiol 2014 Dec; 23(4):292-313
PMID: 25548530 [PubMed - as supplied by publisher]
Hypothesis: somatic mosaicism and Parkinson disease.
Han-Joon Kim, Beom S Jeon
Exp Neurobiol 2014 Dec; 23(4):271-6
PMID: 25548528 [PubMed - as supplied by publisher]
Ultrasound-based motion analysis demonstrates bilateral arm hypokinesia during gait in heterozygous PINK1 mutation carriers.
Lucas NŘrnberger, Christine Klein, Simon Baudrexel, Julia Roggendorf, Marcel Hildner, Shu Chen, Jun-Suk Kang, RŘdiger Hilker, Johann Hagenah
Mov Disord 2014 Dec;
PMID: 25545816 [PubMed - as supplied by publisher]
Parkinson's disease correlates with promoter methylation in the ?-synuclein gene.
Lasse Pihlstr°m, Victoria Berge, Aina Rengmark, Mathias Toft
Mov Disord 2014 Dec;
PMID: 25545759 [PubMed - as supplied by publisher]
A 7.5-Mb duplication at chromosome 11q21-11q22.3 is associated with a novel spastic ataxia syndrome.
Janel O Johnson, Giovanni Stevanin, Joyce van de Leemput, Dena G Hernandez, Sampath Arepalli, Sylvie Forlani, Reza Zonozi, J Raphael Gibbs, Alexis Brice, Alexandra Durr, Andrew B Singleton
Mov Disord 2014 Dec;
PMID: 25545641 [PubMed - as supplied by publisher]
A De Novo ADCY5 mutation causes early-onset autosomal dominant chorea and dystonia.
Raphael Carapito, NicodŔme Paul, Meiggie Untrau, Marion Le Gentil, Louise Ott, Ghada Alsaleh, Pierre Jochem, Mirjana Radosavljevic, CÚdric Le Caignec, Albert David, Philippe Damier, Bertrand Isidor, Seiamak Bahram
Mov Disord 2014 Dec;
PMID: 25545163 [PubMed - as supplied by publisher]
Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers.
Rick C Helmich, Avner Thaler, Bart F L van Nuenen, Tanya Gurevich, Anat Mirelman, Karen S Marder, Susan Bressman, Avi Orr-Urtreger, Nir Giladi, Bastiaan R Bloem, Ivan Toni,
Neurology 2014 Dec;
PMID: 25540317 [PubMed - as supplied by publisher]
The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases.
Sahar Al-Mahdawi, Sara Anjomani Virmouni, Mark A Pook
Front Neurosci 2014 ; 8:397
PMID: 25538551 [PubMed - as supplied by publisher]
Correction: high-frequency stimulation of the subthalamic nucleus counteracts cortical expression of major histocompatibility complex genes in a rat model of Parkinson's disease.
PLoS One 2014 ; 9(12):e116365
PMID: 25536402 [PubMed - as supplied by publisher]
Glucocerebrosidase Gene Mutations Associated with Parkinson's Disease: A Meta-Analysis in a Chinese population.
Jia Chen, Wei Li, Tao Zhang, Yan-Jiang Wang, Xiao-Jiang Jiang, Zhi-Qiang Xu
PLoS One 2014 ; 9(12):e115747
PMID: 25535748 [PubMed - as supplied by publisher]
Vitamin C Facilitates Dopamine Neuron Differentiation in Fetal Midbrain Through Tet1- aND Jmjd3-Dependent Epigenetic Control Manner.
Xi-Biao He, Mirang Kim, Seon-Young Kim, Sang-Hoon Yi, Yong-Hee Rhee, Taeho Kim, Eun-Hye Lee, Chang-Hwan Park, Shilpy Dixit, Fiona E Harrison, Sang-Hun Lee
Stem Cells 2014 Dec;
PMID: 25535150 [PubMed - as supplied by publisher]
Silencing of PINK1 Inhibits Insulin-Like Growth Factor-1-Mediated Receptor Activation and Neuronal Survival.
MarÝa J Contreras-Zßrate, Andrea Ni˝o, Liliana Rojas, Humberto Arboleda, Gonzalo Arboleda
J Mol Neurosci 2014 Dec;
PMID: 25534921 [PubMed - as supplied by publisher]
The RIT2 and STX1B polymorphisms are associated with Parkinson's disease.
Jian-Yong Wang, Mei-Ying Gong, Yang-Lie Ye, Jin-Min Ye, Guo-Liang Lin, Qing-Qing Zhuang, Xiong Zhang, Jian-Hong Zhu
Parkinsonism Relat Disord 2014 Dec;
PMID: 25534083 [PubMed - as supplied by publisher]
Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease?
Nino Spataro, Francesc Calafell, Laura Cervera-Carles, Ferran Casals, Javier Pagonabarraga, Berta Pascual-Sedano, Ant˛nia Campolongo, Jaime Kulisevsky, Alberto Lleˇ, Arcadi Navarro, Jordi Clarimˇn, Elena Bosch
Hum Mol Genet 2014 Dec;
PMID: 25504046 [PubMed - as supplied by publisher]
Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.
Pan Chen, Margaret R DeWitt, Julia Bornhorst, Felix A Soares, Somshuvra Mukhopadhyay, Aaron B Bowman, Michael Aschner
Metallomics 2014 Dec;
PMID: 25531510 [PubMed - as supplied by publisher]
PINK1 Catalytic Activity is Regulated by Phosphorylation on Serines 228 and 402.
Liesbeth Aerts, Katleen Craessaerts, Bart De Strooper, Vanessa A Morais
J Biol Chem 2014 Dec;
PMID: 25527497 [PubMed - as supplied by publisher]
Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra.
Beatriz Raposo Corradini, Priscila Iamashita, Edilaine Tampellini, JosÚ Marcelo Farfel, Lea Tenenholz Grinberg, Carlos Alberto Moreira-Filho
Biomed Res Int 2014 ; 2014:543673
PMID: 25525598 [PubMed - as supplied by publisher]
Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's Disease.
Janelle Drouin-Ouellet, Isabelle St-Amour, Martine Saint-Pierre, JÚr˘me Lamontagne-Proulx, Jasna Kriz, Roger A Barker, Francesca Cicchetti
Int J Neuropsychopharmacol 2014 Dec;
PMID: 25522431 [PubMed - as supplied by publisher]
Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.
Nathan C Rowland, Philip A Starr, Paul S Larson, Jill L Ostrem, William J Marks, Daniel A Lim
Mov Disord 2014 Dec;
PMID: 25521796 [PubMed - as supplied by publisher]
Detection of protein aggregates in brain and cerebrospinal fluid derived from multiple sclerosis patients.
Monique Antoinette David, Mourad Tayebi
Front Neurol 2014 ; 5:251
PMID: 25520699 [PubMed - as supplied by publisher]
Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.
Feng Zhang, Dan Xu, Ling Yuan, Yiming Sun, Zhiheng Xu
Nat Commun 2014 ; 5:5815
PMID: 25519973 [PubMed - as supplied by publisher]
Mutations in the glucocerebrosidase gene are responsible for Chinese patients with Parkinson's disease.
Zhe Yu, Ting Wang, Jun Xu, Wei Wang, Guifang Wang, Chao Chen, Lili Zheng, Li Pan, Dianrong Gong, Xueli Li, Huaiqian Qu, Fang Li, Bin Zhang, Weidong Le, Fabin Han
J Hum Genet 2014 Dec;
PMID: 25518742 [PubMed - as supplied by publisher]
PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.
Michel Belyk, Shelly Jo Kraft, Steven Brown
J Hum Genet 2014 Dec;
PMID: 25518740 [PubMed - as supplied by publisher]
Correction: cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals.
PLoS One 2014 ; 9(12):e116242
PMID: 25517621 [PubMed - as supplied by publisher]
Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats.
Cheng-Long Xie, Wen-Wen Wang, Su-Fang Zhang, Ming-Lu Yuan, Jun-Yi Che, Jing Gan, Lu Song, Wei-En Yuan, Zhen-Guo Liu
Sci Rep 2014 ; 4:7506
PMID: 25511986 [PubMed - as supplied by publisher]
Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra.
Rasajna Nadella, Merja H Voutilainen, Mart Saarma, Juan A Gonzalez-Barrios, Bertha A Leon-Chavez, Judith M Due˝as JimÚnez, Sergio H Due˝as JimÚnez, Lourdes Escobedo, Daniel Martinez-Fong
J Neuroinflammation 2014 Dec; 11(1):209
PMID: 25511018 [PubMed - as supplied by publisher]
Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing ?-synuclein.
Iddo Magen, Regina Ostritsky, Franziska Richter, Chunni Zhu, Sheila M Fleming, Vincent Lemesre, Alistair J Stewart, Bruce H Morimoto, Illana Gozes, Marie-Franšoise Chesselet
Pharmacol Res Perspect 2014 Oct; 2(5):e00065
PMID: 25505609 [PubMed - as supplied by publisher]
Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra.
Panojot Bifsha, Jianqi Yang, Rory A Fisher, Jacques Drouin
PLoS Genet 2014 Dec; 10(12):e1004863
PMID: 25501001 [PubMed - as supplied by publisher]
Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Ruth Chia, Sara Haddock, Alexandra Beilina, Iakov N Rudenko, Adamantios Mamais, Alice Kaganovich, Yan Li, Ravindran Kumaran, Michael A Nalls, Mark R Cookson
Nat Commun 2014 ; 5:5827
PMID: 25500533 [PubMed - as supplied by publisher]
Evolution of Prodromal Clinical Markers of Parkinson Disease in a GBA Mutation-Positive Cohort.
Michelle Beavan, Alisdair McNeill, Christos Proukakis, Derralynn A Hughes, Atul Mehta, Anthony H V Schapira
JAMA Neurol 2014 Dec;
PMID: 25506732 [PubMed - as supplied by publisher]
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Amaia M Arranz, Lore Delbroek, Kristof Van Kolen, Marco R GuimarŃes, Wim Mandemakers, Guy Daneels, Samer Matta, Sara Calafate, Hamdy Shaban, Pieter Baatsen, Pieter-Jan De Bock, Kris Gevaert, Pieter Vanden Berghe, Patrik Verstreken, Bart De Strooper, Diederik Moechars
J Cell Sci 2014 Dec;
PMID: 25501810 [PubMed - as supplied by publisher]
Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson┐s disease ┐ a multicenter study.
Malin von Otter, Petra Bergstr÷m, Aldo Quattrone, Elvira De Marco, Grazia Annesi, Peter S÷derkvist, Stephanie Wettinger, Marek Drozdzik, Monika Bialecka, Hans Nissbrandt, Christine Klein, Michael Nilsson, Ola Hammarsten, Staffan Nilsson, Henrik Zetterberg
BMC Med Genet 2014 Dec; 15(1):131
PMID: 25496089 [PubMed - as supplied by publisher]
Association between two ?-2-macroglobulin gene polymorphisms and Parkinson's disease: a meta-analysis.
Guo Xingzhi, Tang Peng, Li Xiaoqing, Chong Li, Zhang Xin, Li Rui
Int J Neurosci 2014 Dec; :1-19
PMID: 25495992 [PubMed - as supplied by publisher]
How E3 activity of Parkin is enhanced by damaged mitochondria].
Fumika Koyano, Noriyuki Matsuda
Seikagaku 2014 Oct; 86(5):676-82
PMID: 25509337 [PubMed - as supplied by publisher]
Differential Co-Expression between ?-Synuclein and IFN-? Signaling Genes across Development and in Parkinson's Disease.
Noa Liscovitch, Leon French
PLoS One 2014 ; 9(12):e115029
PMID: 25493648 [PubMed - as supplied by publisher]
Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker?
Rachel Saunders-Pullman, Anat Mirelman, Cuiling Wang, Roy N Alcalay, Marta San Luciano, Robert Ortega, Deborah Raymond, Helen Mejia-Santana, Laurie Ozelius, Lorraine Clark, Avi Orr-Utreger, Karen Marder, Nir Giladi, Susan B Bressman
Ann Clin Transl Neurol 2014 Sep; 1(9):670-8
PMID: 25493281 [PubMed - as supplied by publisher]


text:
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