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Featured Research
What can we learn by studying exercise and Parkinson's? PDF-funded researcher Kristen Pickett, Ph.D., is using magnetic resonance imaging to help find answers to improve life for people with PD.
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Causes and Pathology
PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research.
Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members? Please browse PDF's educational materials and programs - which are all available electronically or in print. Order for yourself, a loved one or in bulk for your patients or support group.
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USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
Christian N Cunningham, Joshua M Baughman, Lilian Phu, Joy S Tea, Christine Yu, Mary Coons, Donald S Kirkpatrick, Baris Bingol, Jacob E Corn
Nat Cell Biol 2015 Jan;
PMID: 25621951 [PubMed - as supplied by publisher]
Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice.
B Butler, J Gamble-George, P Prins, A North, J T Clarke, H Khoshbouei
J Addict Prev 2014; 2(2)
PMID: 25621291 [PubMed - as supplied by publisher]
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease.
George E Barreto, Alexander Iarkov, Valentina Echeverria Moran
Front Aging Neurosci 2014 ; 6:340
PMID: 25620929 [PubMed - as supplied by publisher]
Catalpol: A Potential Therapeutic for Neurodegenerative Diseases.
B Jiang, R F Shen, J Bi, X S Tian T Hinchliffe S Tian, T Hinchliffe, Y Xia
Curr Med Chem 2015 Jan;
PMID: 25620103 [PubMed - as supplied by publisher]
Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery.
Xiangmin Lin, Min Shi, Gunasingh Jeyaraj, Romel Dator, James Movius, Patrick Aro, Yoland Smith, Jing Zhang
Biochim Biophys Acta 2015 Jan;
PMID: 25617661 [PubMed - as supplied by publisher]
Glutamate and GABA concentration changes in the globus pallidus internus of Parkinson's patients during performance of implicit and declarative memory tasks: A report of two subjects.
Robert J Buchanan, Klevest Gjini, David Darrow, Georgeta Varga, Jennifer L Robinson, Zoltan Nadasdy
Neurosci Lett 2015 Jan; 589C:73-78
PMID: 25596441 [PubMed - as supplied by publisher]
Rotenone exerts similar stimulatory effects on H2O2 production by isolated brain mitochondria from young-adult and old rats.
Luiz G B Michelini, Tiago R Figueira, Edilene S Siqueira-Santos, Roger F Castilho
Neurosci Lett 2015 Jan; 589C:25-30
PMID: 25596437 [PubMed - as supplied by publisher]
Systemically administered neuregulin-1?1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease.
Candan Depboylu, Thomas W R÷sler, Anderson de Andrade, Wolfgang H Oertel, GŘnter U H÷glinger
J Neurochem 2015 Jan;
PMID: 25581060 [PubMed - as supplied by publisher]
New Roles of Glycosaminoglycans in ?-Synuclein Aggregation in a Cellular Model of Parkinson Disease.
Sonia Lehri-Boufala, Mohand-Ouidir Ouidja, VÚronique Barbier-ChassefiŔre, Emilie HÚnault, Rita Raisman-Vozari, Laure Garrigue-Antar, Dulce Papy-Garcia, Christophe Morin
PLoS One 2015 ; 10(1):e0116641
PMID: 25617759 [PubMed - as supplied by publisher]
Cystamine induces AIF-mediated apoptosis through glutathione depletion.
Sung-Yup Cho, Jin-Haeng Lee, Mi-Kyeong Ju, Eui Man Jeong, Hyo-Jun Kim, Jisun Lim, Seungun Lee, Nam-Hyuk Cho, Hyun Ho Park, Kihang Choi, Ju-Hong Jeon, In-Gyu Kim
Biochim Biophys Acta 2014 Dec; 1853(3):619-631
PMID: 25549939 [PubMed - as supplied by publisher]
Intracellular screening of a peptide library to derive a potent peptide inhibitor of ?-synuclein aggregation.
Harish Cheruvara, Victoria L Allen-Baume, Neil M Kad, Jody M Mason
J Biol Chem 2015 Jan;
PMID: 25616660 [PubMed - as supplied by publisher]
Recent advances in autophagy-based neuroprotection.
Khaled Radad, Rudolf Moldzio, Mubarak Al-Shraim, Barbara Kranner, Christopher Krewenka, Wolf-Dieter Rausch
Expert Rev Neurother 2015 Feb; 15(2):195-205
PMID: 25614954 [PubMed - as supplied by publisher]
Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ADHD research.
Erin M Miller, Jorge E Quintero, Francois Pomerleau, Peter Huettl, Greg A Gerhardt, Paul E A Glaser
J Neurosci Methods 2015 Jan;
PMID: 25614383 [PubMed - as supplied by publisher]
Amyloid ? oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
Kirsten L Viola, William L Klein
Acta Neuropathol 2015 Feb; 129(2):183-206
PMID: 25604547 [PubMed - as supplied by publisher]
Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.
James M Gruschus, Zhiping Jiang, Thai Leong Yap, Stephanie A Hill, Alexander Grishaev, Grzegorz Piszczek, Ellen Sidransky, Jennifer C Lee
Biochem Biophys Res Commun 2015 Jan;
PMID: 25600808 [PubMed - as supplied by publisher]
Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats.
J Jimenez-Martin, L B Lezcano, M E G Fraguela, M-L DÝaz-Hung, T S Sßnchez, J L Almenares, L F Turner
Neuroscience 2015 Jan;
PMID: 25596320 [PubMed - as supplied by publisher]
Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson's disease.
S Mitra, N Chakrabarti, S S Dutta, S Ray, P Bhattacharya, P Sinha, A Bhattacharyya
Neuroscience 2015 Jan;
PMID: 25592425 [PubMed - as supplied by publisher]
Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders.
Joanna Ruszkiewicz, Jan Albrecht
Neurochem Int 2015 Jan;
PMID: 25576182 [PubMed - as supplied by publisher]
Fatty Acid Composition of the Anterior Cingulate Cortex Indicates a High Susceptibility to Lipid Peroxidation in Parkinson's Disease.
Sarah K Abbott, Andrew M Jenner, Adena S Spiro, Marijka Batterham, Glenda M Halliday, Brett Garner
J Parkinsons Dis 2015 Jan;
PMID: 25613350 [PubMed - as supplied by publisher]
The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway.
Feng Gao, Dong Chen, Jianmin Si, Qingsong Hu, Zhenghong Qin, Ming Fang, Guanghui Wang
Hum Mol Genet 2015 Jan;
PMID: 25612572 [PubMed - as supplied by publisher]
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease.
Alicia M Pickrell, Richard J Youle
Neuron 2015 Jan; 85(2):257-273
PMID: 25611507 [PubMed - as supplied by publisher]
Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease.
Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling Ma
Evid Based Complement Alternat Med 2014 ; 2014:729195
PMID: 25610480 [PubMed - as supplied by publisher]
Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD.
Philipp Mahlknecht, Alex Iranzo, Birgit H÷gl, Birgit Frauscher, Christoph MŘller, Joan SantamarÝa, Eduardo Tolosa, Monica Serradell, Thomas Mitterling, Viola Gschliesser, Georg Goebel, Florian Brugger, Christoph Scherfler, Werner Poewe, Klaus Seppi, ,
Neurology 2015 Jan;
PMID: 25609758 [PubMed - as supplied by publisher]
A53T Human ?-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration.
Linan Chen, Zhiguo Xie, Susie Turkson, Xiaoxi Zhuang
J Neurosci 2015 Jan; 35(3):890-905
PMID: 25609609 [PubMed - as supplied by publisher]
The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson's Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia.
Xiqun Chen, Pauline Wales, Luisa Quinti, Fuxing Zuo, SÚbastien Moniot, Fanny Herisson, Nazifa Abdul Rauf, Hua Wang, Richard B Silverman, Cenk Ayata, Michelle M Maxwell, Clemens Steegborn, Michael A Schwarzschild, Tiago F Outeiro, Aleksey G Kazantsev
PLoS One 2015 ; 10(1):e0116919
PMID: 25608039 [PubMed - as supplied by publisher]
Early Parkinson's disease symptoms in ?-synuclein transgenic monkeys.
Yuyu Niu, Xiangyu Guo, Yongchang Chen, Chuan-En Wang, Jinquan Gao, Weili Yang, Yu Kang, Wei Si, Hong Wang, Shang-Hsun Yang, Shihua Li, Weizhi Ji, Xiao-Jiang Li
Hum Mol Genet 2014 Dec;
PMID: 25552648 [PubMed - as supplied by publisher]
Extent of Inhibition of ?-Synuclein Aggregation in Vitro by SUMOylation Is Conjugation Site- and SUMO Isoform-Selective.
Tharindumala Abeywardana, Matthew R Pratt
Biochemistry 2015 Jan;
PMID: 25607946 [PubMed - as supplied by publisher]
PINK1- and PARK2-mediated local mitophagy in distal neuronal axons.
Ghazaleh Ashrafi, Thomas L Schwarz
Autophagy 2015 Jan; :0
PMID: 25607607 [PubMed - as supplied by publisher]
Head injury, potential interaction with genes, and risk for Parkinson's disease.
Jianjun Gao, Rui Liu, Edward Zhao, Xuemei Huang, Michael A Nalls, Andrew B Singleton, Honglei Chen
Parkinsonism Relat Disord 2015 Jan;
PMID: 25603768 [PubMed - as supplied by publisher]
Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.
Anna Kubesova, Hana Tejkalova, Kamila Syslova, Petr Kacer, Jana Vondrousova, Filip Tyls, Michaela Fujakova, Tomas Palenicek, Jiri Horacek
PLoS One 2015 ; 10(1):e0115439
PMID: 25602957 [PubMed - as supplied by publisher]
Molecular Determinants of ?-Synuclein Mutants' Oligomerization and Membrane Interactions.
Igor F Tsigelny, Yuriy Sharikov, Valentina L Kouznetsova, Jerry P Greenberg, Wolf Wrasidlo, Cassia Overk, Tania Gonzalez, Margarita Trejo, Brian Spencer, Kori Kosberg, Eliezer Masliah
ACS Chem Neurosci 2015 Jan;
PMID: 25561023 [PubMed - as supplied by publisher]
Parkinson Disease: Diffusion MR Imaging to Detect Nigrostriatal Pathway Loss in a Marmoset Model Treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Keigo Hikishima, Kiyoshi Ando, Ryutaro Yano, Kenji Kawai, Yuji Komaki, Takashi Inoue, Toshio Itoh, Masayuki Yamada, Suketaka Momoshima, Hirotaka J Okano, Hideyuki Okano
Radiology 2015 Jan; :140601
PMID: 25602507 [PubMed - as supplied by publisher]
CHIP is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Amy Marie Palubinsky, Jeannette Nicole Stankowski, Alixandra Cozette Kale, Simona G Codreanu, Robert J Singer, Daniel C Liebler, Gregg D Stanwood, BethAnn Marie McLaughlin
Antioxid Redox Signal 2015 Jan;
PMID: 25602369 [PubMed - as supplied by publisher]
Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.
C L Bethea, A P Reddy
Mol Psychiatry 2015 Jan;
PMID: 25600110 [PubMed - as supplied by publisher]
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Anke Van der Perren, Jaan Toelen, Cindy Casteels, Francesca Macchi, Anne-Sophie Van Rompuy, Sophie Sarre, Nicolas Casadei, Silke Nuber, Uwe Himmelreich, Maria Isabel Osorio Garcia, Yvette Michotte, Rudi D'Hooge, Guy Bormans, Koen Van Laere, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2014 Dec;
PMID: 25599874 [PubMed - as supplied by publisher]
Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle.
S Pablo Sardi, Seng H Cheng, Lamya S Shihabuddin
Prog Neurobiol 2015 Jan;
PMID: 25573151 [PubMed - as supplied by publisher]
Attenuation of the Early Events of ?-Synuclein Aggregation: A Fluorescence Correlation Spectroscopy and Laser Scanning Microscopy Study in the Presence of Surface-Coated Fe3O4 Nanoparticles.
Nidhi Joshi, Sujit Basak, Sangeeta Kundu, Goutam De, Anindita Mukhopadhyay, Krishnananda Chattopadhyay
Langmuir 2015 Jan;
PMID: 25561279 [PubMed - as supplied by publisher]
Saliva ?-Synuclein and A High Extinction Coefficient Protein: A Novel Approach in Assessment Biomarkers of Parkinson's Disease.
Marwan S M Al-Nimer, Sabah F Mshatat, Hajer I Abdulla
N Am J Med Sci 2014 Dec; 6(12):633-7
PMID: 25599051 [PubMed - as supplied by publisher]
The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.
Gerwyn Morris, Michael Berk, Piotr Galecki, Ken Walder, Michael Maes
Mol Neurobiol 2015 Jan;
PMID: 25598355 [PubMed - as supplied by publisher]
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.
Yu Tang, Weidong Le
Mol Neurobiol 2015 Jan;
PMID: 25598354 [PubMed - as supplied by publisher]
Purine metabolism gene deregulation in Parkinson's disease.
Paula Garcia-Esparcia, Karina Hernßndez-Ortega, BelÚn Ansoleaga, Margarita Carmona, Isidre Ferrer
Neuropathol Appl Neurobiol 2015 Jan;
PMID: 25597950 [PubMed - as supplied by publisher]
Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice.
Yuki Kambe, Atsuro Miyata
Neurosci Lett 2015 Jan; 588C:166-171
PMID: 25576703 [PubMed - as supplied by publisher]
Small heat shock proteins: Role in cellular functions and pathology.
Raman Bakthisaran, Ramakrishna Tangirala, Ch Mohan Rao
Biochim Biophys Acta 2014 Dec; 1854(4):291-319
PMID: 25556000 [PubMed - as supplied by publisher]
Possible involvement of iron-induced oxidative insults in neurodegeneration.
Takeshi Asano, Masato Koike, Shin-Ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai
Neurosci Lett 2014 Dec; 588C:29-35
PMID: 25549542 [PubMed - as supplied by publisher]
Changes in Neuronal Dopamine Homeostasis Following 1-Methyl-4-Phenylpyridinium (MPP+) Exposure.
Se Joon Choi, Anne Panhelainen, Yvonne Schmitz, Kristin E Larsen, Ellen Kanter, Min Wu, David Sulzer, Eugene V Mosharov
J Biol Chem 2015 Jan;
PMID: 25596531 [PubMed - as supplied by publisher]
Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mTOR-independent autophagy.
Yukiko Sasazawa, Natsumi Sato, Kazuo Umezawa, Siro Simizu
J Biol Chem 2015 Jan;
PMID: 25596530 [PubMed - as supplied by publisher]
Lysosomal-associated membrane protein 2 Isoforms Are Differentially Affected in Early Parkinson's Disease.
Karen E Murphy, Amanda M Gysbers, Sarah K Abbott, Adena S Spiro, Akiko Furuta, Antony Cooper, Brett Garner, Tomohiro Kabuta, Glenda M Halliday
Mov Disord 2015 Jan;
PMID: 25594542 [PubMed - as supplied by publisher]
COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese.
Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu
Mov Disord 2015 Jan;
PMID: 25594503 [PubMed - as supplied by publisher]
Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases.
Isha Solanki, Priyanka Parihar, Mohammad Lukman Mansuri, Mordhwaj S Parihar
Adv Nutr 2015 Jan; 6(1):64-72
PMID: 25593144 [PubMed - as supplied by publisher]
Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease.
Kazuki Ide, Hiroshi Yamada, Keizo Umegaki, Katsuki Mizuno, Nobuko Kawakami, Yuka Hagiwara, Mizuki Matsumoto, Hidefumi Yoshida, Kang Kim, Emi Shiosaki, Tsunehiro Yokochi, Kiyoshi Harada
Nutrition 2015 Feb; 31(2):406-8
PMID: 25592020 [PubMed - as supplied by publisher]
Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease.
Joel Henrique Ellwanger, PatrÝcia Molz, Danieli Rosane Dallemole, Ariana Pereira Dos Santos, Talise Ellwanger MŘller, Lucas Cappelletti, Manoela Gonšalves da Silva, Silvia Isabel Rech Franke, Daniel Prß, JoŃo Antonio Pŕgas Henriques
Nutrition 2015 Feb; 31(2):359-65
PMID: 25592015 [PubMed - as supplied by publisher]
Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-? hydroxysteroid dehydrogenase type 10.
G Bertolin, M Jacoupy, S Traver, R Ferrando-Miguel, T Saint Georges, K Grenier, H Ardila-Osorio, M-P Muriel, H Takahashi, A J Lees, C Gautier, D Guedin, F Coge, E A Fon, A Brice, O Corti
Cell Death Differ 2015 Jan;
PMID: 25591737 [PubMed - as supplied by publisher]
Neuronal cell cycle: The neuron itself and its circumstances.
JosÚ M Frade, MarÝa C Ovejero-Benito
Cell Cycle 2015 Jan; :0
PMID: 25590687 [PubMed - as supplied by publisher]
A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes.
N K Magdalinou, R W Paterson, J M Schott, N C Fox, C Mummery, K Blennow, K Bhatia, H R Morris, P Giunti, T T Warner, R de Silva, A J Lees, H Zetterberg
J Neurol Neurosurg Psychiatry 2015 Jan;
PMID: 25589779 [PubMed - as supplied by publisher]
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration.
Robert P Friedland
J Alzheimers Dis 2015 Jan;
PMID: 25589730 [PubMed - as supplied by publisher]
Colonic mucosal ?-synuclein lacks specificity as a biomarker for Parkinson disease.
Naomi P Visanji, Connie Marras, Drew S Kern, Amaal Al Dakheel, Andrew Gao, Louis W C Liu, Anthony E Lang, Lili-Naz Hazrati
Neurology 2015 Jan;
PMID: 25589666 [PubMed - as supplied by publisher]
Autophagy Inhibition by Caffeine Increases Toxicity of Methamphetamine in SH-SY5Y Neuroblastoma Cell Line.
Rujiraporn Pitaksalee, Yupin Sanvarinda, Theerin Sinchai, Pantip Sanvarinda, Anusorn Thampithak, Nattinee Jantaratnotai, Surawat Jariyawat, Patoomratana Tuchinda, Piyarat Govitrapong, Pimtip Sanvarinda
Neurotox Res 2015 Jan;
PMID: 25588864 [PubMed - as supplied by publisher]
Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease.
Iddo Magen, Eileen Ruth Torres, Diana Dinh, Andrew Chung, Eliezer Masliah, Marie-Franšoise Chesselet
J Parkinsons Dis 2015 Jan;
PMID: 25588356 [PubMed - as supplied by publisher]
Role of ?-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease.
Heather E Allen Reish, David G Standaert
J Parkinsons Dis 2015 Jan;
PMID: 25588354 [PubMed - as supplied by publisher]
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism.
Nikenza Viceconte, Miguel A Burguillos, Antonio J Herrera, RocÝo M De Pablos, Bertrand Joseph, JosÚ L Venero
J Neuroinflammation 2015 Jan; 12(1):5
PMID: 25586882 [PubMed - as supplied by publisher]
Loss of the preferential control over the striato-nigral direct pathway by striatal NMDA receptors in a rat model of Parkinson's disease.
Michele Morari, Martina Fantin
Analyst 2015 Jan;
PMID: 25584655 [PubMed - as supplied by publisher]
STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
Pradeep K Kurup, Jian Xu, Rita Alexandra Videira, Chimezie Ononenyi, Graša Baltazar, Paul J Lombroso, Angus C Nairn
Proc Natl Acad Sci U S A 2015 Jan;
PMID: 25583483 [PubMed - as supplied by publisher]
Fibril Breaking Accelerates ?-Synuclein Fibrillization.
Volodymyr V Shvadchak, Mireille M A E Claessens, Vinod Subramaniam
J Phys Chem B 2015 Jan;
PMID: 25582977 [PubMed - as supplied by publisher]
Recent advances in biomarkers for Parkinson's disease focusing on biochemicals, omics and neuroimaging.
Rutong Ren, Yi Sun, Xin Zhao, Xiaoping Pu
Clin Chem Lab Med 2015 Jan;
PMID: 25581757 [PubMed - as supplied by publisher]
Lipid peroxidation is essential for ?-synuclein-induced cell death.
Plamena R Angelova, Mathew H Horrocks, David Klenerman, Sonia Gandhi, Andrey Y Abramov, Mikhail S Shchepinov
J Neurochem 2015 Jan;
PMID: 25580849 [PubMed - as supplied by publisher]
Alpha-synuclein biology in Lewy body diseases.
Woojin Scott Kim, Katarina Kňgedal, Glenda M Halliday
Alzheimers Res Ther 2014 ; 6(5):73
PMID: 25580161 [PubMed - as supplied by publisher]
Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression.
Ling-Hsuan Wu, Chingju Lin, Hsiao-Yun Lin, Yu-Shu Liu, Caren Yu-Ju Wu, Cheng-Fang Tsai, Pei-Chun Chang, Wei-Lan Yeh, Dah-Yuu Lu
Mol Neurobiol 2015 Jan;
PMID: 25579382 [PubMed - as supplied by publisher]
S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP's anti-caspase 3 activity and anti-apoptotic function.
Weiwei Wu, Oi Wan Wan, Kenny K K Chung
Apoptosis 2015 Jan;
PMID: 25578648 [PubMed - as supplied by publisher]
Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.
Jing Xiong, Xiaowei Zhang, Jinsha Huang, Chunnuan Chen, Zhenzhen Chen, Ling Liu, Guoxin Zhang, Jiaolong Yang, Zhentao Zhang, Zhaohui Zhang, Zhicheng Lin, Nian Xiong, Tao Wang
Mol Neurobiol 2015 Jan;
PMID: 25575680 [PubMed - as supplied by publisher]
Cucurbitacin e has neuroprotective properties and autophagic modulating activities on dopaminergic neurons.
Anne-Marie Arel-Dubeau, Fanny LongprÚ, Julie Bournival, Cindy Tremblay, Julie Demers-Lamarche, Pavlina Haskova, Everaldo Attard, Marc Germain, Maria-Grazia Martinoli
Oxid Med Cell Longev 2014 ; 2014:425496
PMID: 25574337 [PubMed - as supplied by publisher]
Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenone.
Zhong-Kui Xiong, Juan Lang, Gang Xu, Hai-Yu Li, Yun Zhang, Lei Wang, Yao Su, Ai-Jing Sun
Exp Ther Med 2015 Feb; 9(2):553-558
PMID: 25574233 [PubMed - as supplied by publisher]
Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion?induced neurotoxicity in PC12 cells.
Weihai Liu, Songzhi Kong, Qingfeng Xie, Jiyan Su, Wenjie Li, Huizhen Guo, Shanshan Li, Xuexuan Feng, Ziren Su, Yang Xu, Xiaoping Lai
Int J Mol Med 2014 Dec;
PMID: 25573459 [PubMed - as supplied by publisher]
Discovery of functional non-coding conserved regions in the ?-synuclein gene locus.
Lori Sterling, Michael Walter, Dennis Ting, Birgitt SchŘle
F1000Res 2014 ; 3:259
PMID: 25566351 [PubMed - as supplied by publisher]
Parkinson's disease assessment based on gait analysis using an innovative RGB-D camera system.
Ana Patricia Rocha, Hugo Choupina, Jose Maria Fernandes, Maria Jose Rosas, Rui Vaz, Joao Paulo Silva Cunha
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3126-9
PMID: 25570653 [PubMed - as supplied by publisher]
Linking the VPS35 and EIF4G1 Pathways in Parkinson's Disease.
Owen A Ross, Casey Cook, Leonard Petrucelli
Neuron 2015 Jan; 85(1):1-3
PMID: 25569341 [PubMed - as supplied by publisher]
Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.
Fanny Charbonnier-Beaupel, Marion Malerbi, Cristina Alcacer, Khadija Tahiri, Wassila Carpentier, Chuansong Wang, Matthew During, Desheng Xu, Paul F Worley, Jean-Antoine Girault, Denis HervÚ, Jean-Christophe Corvol
J Neurosci 2015 Jan; 35(1):96-111
PMID: 25568106 [PubMed - as supplied by publisher]
Protein Phosphatase 2A is Involved in the Tyrosine Hydroxylase Phosphorylation Regulated by ?-Synuclein.
Gao Hua, Lan Xiaolei, Yang Weiwei, Wang Hao, Zhu Yuangang, Liu Dongmei, Zhang Yazhuo, Yang Hui
Neurochem Res 2015 Jan;
PMID: 25567480 [PubMed - as supplied by publisher]
Alpha-synuclein spreading in Parkinson's disease.
Ariadna Recasens, Benjamin Dehay
Front Neuroanat 2014 ; 8:159
PMID: 25565982 [PubMed - as supplied by publisher]
Parkinson's disease: animal models and dopaminergic cell vulnerability.
Javier Blesa, Serge Przedborski
Front Neuroanat 2014 ; 8:155
PMID: 25565980 [PubMed - as supplied by publisher]
Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update.
Lars Brichta, Paul Greengard
Front Neuroanat 2014 ; 8:152
PMID: 25565977 [PubMed - as supplied by publisher]
PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane.
Stephan Gehrke, Zhihao Wu, Michael Klinkenberg, Yaping Sun, Georg Auburger, Su Guo, Bingwei Lu
Cell Metab 2015 Jan; 21(1):95-108
PMID: 25565208 [PubMed - as supplied by publisher]
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases.
Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Patrick Boissin, Edilio Borroni, Bernd BŘttelmann, Simona Ceccarelli, Nicole Clemann, Beatrice David, Christoph Funk, Wolfgang Guba, Anthony Harrison, Thomas Hartung, Michael Honer, J÷rg Huwyler, Martin Kuratli, Urs Niederhauser, Axel Pńhler, Jens-Uwe Peters, Ann Petersen, Eric Prinssen, Antonio Ricci, Daniel Rueher, Marianne Rueher, Manfred Schneider, Paul Spurr, Theodor Stoll, Daniel Tńnnler, JŘrgen Wichmann, Richard H Porter, Joseph G Wettstein, Lothar Lindemann
J Med Chem 2015 Jan;
PMID: 25565255 [PubMed - as supplied by publisher]
An overview on the correlation of neurological disorders with cardiovascular disease.
C K Firoz, Nasimudeen R Jabir, Mohd Shahnawaz Khan, Maged Mahmoud, Shazi Shakil, Ghazi A Damanhouri, Syed Kashif Zaidi, Shams Tabrez, Mohammad A Kamal
Saudi J Biol Sci 2015 Jan; 22(1):19-23
PMID: 25561878 [PubMed - as supplied by publisher]
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J Biol Chem 2015 Jan;
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text:
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Nod Exclusive
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King James Version (KJV) | New International Version (NIV) |
1 Again the word of the LORD came unto me, saying , | 1 The word of the LORD came to me: |
2 Son of man, cause Jerusalem to know her abominations, | 2 "Son of man, confront Jerusalem with her detestable practices |
3 And say , Thus saith the Lord GOD unto Jerusalem; Thy birth and thy nativity is of the land of Canaan; thy father was an Amorite, and thy mother an Hittite. | 3 and say, 'This is what the Sovereign LORD says to Jerusalem: Your ancestry and birth were in the land of the Canaanites; your father was an Amorite and your mother a Hittite. |
4 And as for thy nativity, in the day thou wast born thy navel was not cut , neither wast thou washed in water to supple thee; thou wast not salted at all , nor swaddled at all . | 4 On the day you were born your cord was not cut, nor were you washed with water to make you clean, nor were you rubbed with salt or wrapped in cloths. |
5 None eye pitied thee, to do any of these unto thee, to have compassion upon thee; but thou wast cast out in the open field, to the lothing of thy person, in the day that thou wast born . | 5 No one looked on you with pity or had compassion enough to do any of these things for you. Rather, you were thrown out into the open field, for on the day you were born you were despised. |
6 And when I passed by thee, and saw thee polluted in thine own blood, I said unto thee when thou wast in thy blood, Live ; yea, I said unto thee when thou wast in thy blood, Live . | 6 " 'Then I passed by and saw you kicking about in your blood, and as you lay there in your blood I said to you, "Live!" |
7 I have caused thee to multiply as the bud of the field, and thou hast increased and waxen great , and thou art come to excellent ornaments: thy breasts are fashioned , and thine hair is grown , whereas thou wast naked and bare. | 7 I made you grow like a plant of the field. You grew up and developed and became the most beautiful of jewels. Your breasts were formed and your hair grew, you who were naked and bare. |
8 Now when I passed by thee, and looked upon thee, behold, thy time was the time of love; and I spread my skirt over thee, and covered thy nakedness: yea, I sware unto thee, and entered into a covenant with thee, saith the Lord GOD, and thou becamest mine. | 8 " 'Later I passed by, and when I looked at you and saw that you were old enough for love, I spread the corner of my garment over you and covered your nakedness. I gave you my solemn oath and entered into a covenant with you, declares the Sovereign LORD, and you became mine. |
9 Then washed I thee with water; yea, I throughly washed away thy blood from thee, and I anointed thee with oil. | 9 " 'I bathed you with water and washed the blood from you and put ointments on you. |
10 I clothed thee also with broidered work, and shod thee with badgers' skin, and I girded thee about with fine linen, and I covered thee with silk. | 10 I clothed you with an embroidered dress and put leather sandals on you. I dressed you in fine linen and covered you with costly garments. |
11 I decked thee also with ornaments, and I put bracelets upon thy hands, and a chain on thy neck. | 11 I adorned you with jewelry: I put bracelets on your arms and a necklace around your neck, |
12 And I put a jewel on thy forehead, and earrings in thine ears, and a beautiful crown upon thine head. | 12 and I put a ring on your nose, earrings on your ears and a beautiful crown on your head. |
13 Thus wast thou decked with gold and silver; and thy raiment was of fine linen , and silk, and broidered work; thou didst eat fine flour, and honey, and oil: and thou wast exceeding beautiful , and thou didst prosper into a kingdom. | 13 So you were adorned with gold and silver; your clothes were of fine linen and costly fabric and embroidered cloth. Your food was fine flour, honey and olive oil. You became very beautiful and rose to be a queen. |
14 And thy renown went forth among the heathen for thy beauty: for it was perfect through my comeliness, which I had put upon thee, saith the Lord GOD. | 14 And your fame spread among the nations on account of your beauty, because the splendor I had given you made your beauty perfect, declares the Sovereign LORD. |
15 But thou didst trust in thine own beauty, and playedst the harlot because of thy renown, and pouredst out thy fornications on every one that passed by ; his it was. | 15 " 'But you trusted in your beauty and used your fame to become a prostitute. You lavished your favors on anyone who passed by and your beauty became his. |
16 And of thy garments thou didst take , and deckedst thy high places with divers colours , and playedst the harlot thereupon: the like things shall not come , neither shall it be so. | 16 You took some of your garments to make gaudy high places, where you carried on your prostitution. Such things should not happen, nor should they ever occur. |
17 Thou hast also taken thy fair jewels of my gold and of my silver, which I had given thee, and madest to thyself images of men, and didst commit whoredom with them, | 17 You also took the fine jewelry I gave you, the jewelry made of my gold and silver, and you made for yourself male idols and engaged in prostitution with them. |
18 And tookest thy broidered garments, and coveredst them: and thou hast set mine oil and mine incense before them. | 18 And you took your embroidered clothes to put on them, and you offered my oil and incense before them. |
19 My meat also which I gave thee, fine flour, and oil, and honey, wherewith I fed thee, thou hast even set it before them for a sweet savour: and thus it was, saith the Lord GOD. | 19 Also the food I provided for you--the fine flour, olive oil and honey I gave you to eat--you offered as fragrant incense before them. That is what happened, declares the Sovereign LORD. |
20 Moreover thou hast taken thy sons and thy daughters, whom thou hast borne unto me, and these hast thou sacrificed unto them to be devoured . Is this of thy whoredoms a small matter, | 20 " 'And you took your sons and daughters whom you bore to me and sacrificed them as food to the idols. Was your prostitution not enough? |
21 That thou hast slain my children, and delivered them to cause them to pass through the fire for them? | 21 You slaughtered my children and sacrificed them to the idols. |
22 And in all thine abominations and thy whoredoms thou hast not remembered the days of thy youth, when thou wast naked and bare, and wast polluted in thy blood. | 22 In all your detestable practices and your prostitution you did not remember the days of your youth, when you were naked and bare, kicking about in your blood. |
23 And it came to pass after all thy wickedness, (woe, woe unto thee! saith the Lord GOD;) | 23 " 'Woe! Woe to you, declares the Sovereign LORD. In addition to all your other wickedness, |
24 That thou hast also built unto thee an eminent place, and hast made thee an high place in every street. | 24 you built a mound for yourself and made a lofty shrine in every public square. |
25 Thou hast built thy high place at every head of the way, and hast made thy beauty to be abhorred , and hast opened thy feet to every one that passed by , and multiplied thy whoredoms. | 25 At the head of every street you built your lofty shrines and degraded your beauty, offering your body with increasing promiscuity to anyone who passed by. |
26 Thou hast also committed fornication with the Egyptians thy neighbours, great of flesh; and hast increased thy whoredoms, to provoke me to anger . | 26 You engaged in prostitution with the Egyptians, your lustful neighbors, and provoked me to anger with your increasing promiscuity. |
27 Behold, therefore I have stretched out my hand over thee, and have diminished thine ordinary food, and delivered thee unto the will of them that hate thee, the daughters of the Philistines, which are ashamed of thy lewd way. | 27 So I stretched out my hand against you and reduced your territory; I gave you over to the greed of your enemies, the daughters of the Philistines, who were shocked by your lewd conduct. |
28 Thou hast played the whore also with the Assyrians , because thou wast unsatiable ; yea, thou hast played the harlot with them, and yet couldest not be satisfied. | 28 You engaged in prostitution with the Assyrians too, because you were insatiable; and even after that, you still were not satisfied. |
29 Thou hast moreover multiplied thy fornication in the land of Canaan unto Chaldea; and yet thou wast not satisfied herewith. | 29 Then you increased your promiscuity to include Babylonia, a land of merchants, but even with this you were not satisfied. |
30 How weak is thine heart, saith the Lord GOD, seeing thou doest all these things, the work of an imperious whorish woman; | 30 " 'How weak-willed you are, declares the Sovereign LORD, when you do all these things, acting like a brazen prostitute! |
31 In that thou buildest thine eminent place in the head of every way, and makest thine high place in every street; and hast not been as an harlot , in that thou scornest hire; | 31 When you built your mounds at the head of every street and made your lofty shrines in every public square, you were unlike a prostitute, because you scorned payment. |
32 But as a wife that committeth adultery , which taketh strangers instead of her husband! | 32 " 'You adulterous wife! You prefer strangers to your own husband! |
33 They give gifts to all whores : but thou givest thy gifts to all thy lovers , and hirest them, that they may come unto thee on every side for thy whoredom. | 33 Every prostitute receives a fee, but you give gifts to all your lovers, bribing them to come to you from everywhere for your illicit favors. |
34 And the contrary is in thee from other women in thy whoredoms, whereas none followeth thee to commit whoredoms : and in that thou givest a reward, and no reward is given unto thee, therefore thou art contrary. | 34 So in your prostitution you are the opposite of others; no one runs after you for your favors. You are the very opposite, for you give payment and none is given to you. |
35 Wherefore, O harlot , hear the word of the LORD: | 35 " 'Therefore, you prostitute, hear the word of the LORD! |
36 Thus saith the Lord GOD; Because thy filthiness was poured out , and thy nakedness discovered through thy whoredoms with thy lovers , and with all the idols of thy abominations, and by the blood of thy children, which thou didst give unto them; | 36 This is what the Sovereign LORD says: Because you poured out your wealth and exposed your nakedness in your promiscuity with your lovers, and because of all your detestable idols, and because you gave them your children's blood, |
37 Behold, therefore I will gather all thy lovers , with whom thou hast taken pleasure , and all them that thou hast loved , with all them that thou hast hated ; I will even gather them round about against thee, and will discover thy nakedness unto them, that they may see all thy nakedness. | 37 therefore I am going to gather all your lovers, with whom you found pleasure, those you loved as well as those you hated. I will gather them against you from all around and will strip you in front of them, and they will see all your nakedness. |
38 And I will judge thee, as women that break wedlock and shed blood are judged; and I will give thee blood in fury and jealousy. | 38 I will sentence you to the punishment of women who commit adultery and who shed blood; I will bring upon you the blood vengeance of my wrath and jealous anger. |
39 And I will also give thee into their hand, and they shall throw down thine eminent place, and shall break down thy high places: they shall strip thee also of thy clothes, and shall take thy fair jewels, and leave thee naked and bare. | 39 Then I will hand you over to your lovers, and they will tear down your mounds and destroy your lofty shrines. They will strip you of your clothes and take your fine jewelry and leave you naked and bare. |
40 They shall also bring up a company against thee, and they shall stone thee with stones, and thrust thee through with their swords. | 40 They will bring a mob against you, who will stone you and hack you to pieces with their swords. |
41 And they shall burn thine houses with fire, and execute judgments upon thee in the sight of many women: and I will cause thee to cease from playing the harlot , and thou also shalt give no hire any more. | 41 They will burn down your houses and inflict punishment on you in the sight of many women. I will put a stop to your prostitution, and you will no longer pay your lovers. |
42 So will I make my fury toward thee to rest , and my jealousy shall depart from thee, and I will be quiet , and will be no more angry . | 42 Then my wrath against you will subside and my jealous anger will turn away from you; I will be calm and no longer angry. |
43 Because thou hast not remembered the days of thy youth, but hast fretted me in all these things; behold, therefore I also will recompense thy way upon thine head, saith the Lord GOD: and thou shalt not commit this lewdness above all thine abominations. | 43 " 'Because you did not remember the days of your youth but enraged me with all these things, I will surely bring down on your head what you have done, declares the Sovereign LORD. Did you not add lewdness to all your other detestable practices? |
44 Behold, every one that useth proverbs shall use this proverb against thee, saying , As is the mother, so is her daughter. | 44 " 'Everyone who quotes proverbs will quote this proverb about you: "Like mother, like daughter." |
45 Thou art thy mother's daughter, that lotheth her husband and her children; and thou art the sister of thy sisters, which lothed their husbands and their children: your mother was an Hittite, and your father an Amorite. | 45 You are a true daughter of your mother, who despised her husband and her children; and you are a true sister of your sisters, who despised their husbands and their children. Your mother was a Hittite and your father an Amorite. |
46 And thine elder sister is Samaria, she and her daughters that dwell at thy left hand: and thy younger sister, that dwelleth at thy right hand, is Sodom and her daughters. | 46 Your older sister was Samaria, who lived to the north of you with her daughters; and your younger sister, who lived to the south of you with her daughters, was Sodom. |
47 Yet hast thou not walked after their ways, nor done after their abominations: but, as if that were a very little thing, thou wast corrupted more than they in all thy ways. | 47 You not only walked in their ways and copied their detestable practices, but in all your ways you soon became more depraved than they. |
48 As I live, saith the Lord GOD, Sodom thy sister hath not done , she nor her daughters, as thou hast done , thou and thy daughters. | 48 As surely as I live, declares the Sovereign LORD, your sister Sodom and her daughters never did what you and your daughters have done. |
49 Behold, this was the iniquity of thy sister Sodom, pride, fulness of bread, and abundance of idleness was in her and in her daughters, neither did she strengthen the hand of the poor and needy. | 49 " 'Now this was the sin of your sister Sodom: She and her daughters were arrogant, overfed and unconcerned; they did not help the poor and needy. |
50 And they were haughty , and committed abomination before me: therefore I took them away as I saw good. | 50 They were haughty and did detestable things before me. Therefore I did away with them as you have seen. |
51 Neither hath Samaria committed half of thy sins; but thou hast multiplied thine abominations more than they, and hast justified thy sisters in all thine abominations which thou hast done . | 51 Samaria did not commit half the sins you did. You have done more detestable things than they, and have made your sisters seem righteous by all these things you have done. |
52 Thou also, which hast judged thy sisters, bear thine own shame for thy sins that thou hast committed more abominable than they: they are more righteous than thou: yea, be thou confounded also, and bear thy shame, in that thou hast justified thy sisters. | 52 Bear your disgrace, for you have furnished some justification for your sisters. Because your sins were more vile than theirs, they appear more righteous than you. So then, be ashamed and bear your disgrace, for you have made your sisters appear righteous. |
53 When I shall bring again their captivity , the captivity of Sodom and her daughters, and the captivity of Samaria and her daughters, then will I bring again the captivity of thy captives in the midst of them: | 53 " 'However, I will restore the fortunes of Sodom and her daughters and of Samaria and her daughters, and your fortunes along with them, |
54 That thou mayest bear thine own shame, and mayest be confounded in all that thou hast done , in that thou art a comfort unto them. | 54 so that you may bear your disgrace and be ashamed of all you have done in giving them comfort. |
55 When thy sisters, Sodom and her daughters, shall return to their former estate, and Samaria and her daughters shall return to their former estate, then thou and thy daughters shall return to your former estate. | 55 And your sisters, Sodom with her daughters and Samaria with her daughters, will return to what they were before; and you and your daughters will return to what you were before. |
56 For thy sister Sodom was not mentioned by thy mouth in the day of thy pride, | 56 You would not even mention your sister Sodom in the day of your pride, |
57 Before thy wickedness was discovered , as at the time of thy reproach of the daughters of Syria, and all that are round about her, the daughters of the Philistines, which despise thee round about. | 57 before your wickedness was uncovered. Even so, you are now scorned by the daughters of Edom and all her neighbors and the daughters of the Philistines--all those around you who despise you. |
58 Thou hast borne thy lewdness and thine abominations, saith the LORD. | 58 You will bear the consequences of your lewdness and your detestable practices, declares the LORD. |
59 For thus saith the Lord GOD; I will even deal with thee as thou hast done , which hast despised the oath in breaking the covenant. | 59 " 'This is what the Sovereign LORD says: I will deal with you as you deserve, because you have despised my oath by breaking the covenant. |
60 Nevertheless I will remember my covenant with thee in the days of thy youth, and I will establish unto thee an everlasting covenant. | 60 Yet I will remember the covenant I made with you in the days of your youth, and I will establish an everlasting covenant with you. |
61 Then thou shalt remember thy ways, and be ashamed , when thou shalt receive thy sisters, thine elder and thy younger: and I will give them unto thee for daughters, but not by thy covenant. | 61 Then you will remember your ways and be ashamed when you receive your sisters, both those who are older than you and those who are younger. I will give them to you as daughters, but not on the basis of my covenant with you. |
62 And I will establish my covenant with thee; and thou shalt know that I am the LORD: | 62 So I will establish my covenant with you, and you will know that I am the LORD. |
63 That thou mayest remember , and be confounded , and never open thy mouth any more because of thy shame, when I am pacified toward thee for all that thou hast done , saith the Lord GOD. | 63 Then, when I make atonement for you for all you have done, you will remember and be ashamed and never again open your mouth because of your humiliation, declares the Sovereign LORD.' " |
The King James Version is in the public domain. (The King James Bible Version Online) | Scripture quoted by permission. Quotations designated (NIV) are from THE HOLY BIBLE: NEW INTERNATIONAL VERSION®. NIV®. Copyright © 1973, 1978, 1984 by Biblica. All rights reserved worldwide. (New International Version Bible Online) |


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Our delicious beef is from cattle that have been fed a grass and cereal based diet on specially selected farms that we trust, matured for a minimum of 21 days, ensuring the best flavour and texture.
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- Weight: 2275 g
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- Consume Within: 11 days
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Preparation and serving
- Cooking Instructions: Oven- Preheat oven 150°C / Fan 130°C / 300°F / Gas mark 2. Remove joint from packaging and allow to breathe at room temperature for 15 minutes. For best results, brush the joint with vegetable oil and sear all over in a frying pan set at high heat. Transfer the joint to a roasting tray. Season with coarse sea salt and cracked black pepper. Place on middle shelf of oven. Baste frequently during cooking. Rare- 35 mins per 500g. Medium- 45 mins per 500g. Well done- 60 mins per 500g. Remove from oven, cover with foil and allow to stand for 15 minutes before carving. Do not reheat
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Sculpture Trail - Wynyard Quarter
Artistic day
This photo was shot on film. Taken by ting_jez with a Lomography Diana F+ (available in our Online Shop) loaded with Kodak Portra film in Auckland, New Zealand. These tags describe this photo: silo, quarter, wynyard, sculptures, and art. Date: 2013-02-09. This photo can also be found in the album Lomo Group - Sculpture Walk .Please login to get more out of this site
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"Delicious! I saved the best for last. Made just as directed, and the only change I would make in the future is to use a 9x9 pan or double the crust so that the crust is a little bit thicker. I would like to make these for the bake sale, but the thin crust is too fragile. The flavor though, it outstanding. I mixed both the crust and the fillin..."
"Made some last minute plans to have a couple girls over last night for a drink... or two. I had plenty of beverage choices, but was worried about having mixers. Someone said, "A martini sounds good." so I searched. I had lemons on hand and have always loved the lemon drop, so I made up three of them, and then a very short time later ..."
"November 15, 2013: I was so looking forward to this recipe, I just wish I had read Jude's review before making it myself. We aren't going to get to eat this batch, but I'll definitely try it again this weekend. The first change I'll have to make is not using my jelly roll pan. The crackers (I used Saltines, cause I liked th..."
"This is, without a doubt, the most perfect prime rib we've ever had. DH said it's even better than any one he's ever eaten at a restaurant. DD (7 yrs old), who rarely eats red meat, could not keep her hands off the carving board and had eaten a meal's worth by the time we sat down! She also helped me make the recipe, which w..."
"We loved the flavor of these potatoes. They tasted like our favorite baked sweet potatoes that have a brown sugar, butter and pecan topping. My only change next time will be to steam the potatoes for about half the time I did last night. I used my rice/veggie steamer and steamed the sliced potatoes for 35 minutes. Next time I'll only stea..."
"This was a welcome find after making Pammy's Recipe #506915 with a big bowl that was still too small for the strawberry jam I was making. The ammonia smell didn't bother me, and maybe it was because we had the kitchen filled with strawberry scent, or because I am used to the smell of the acetone I use when I fill my acrylic nails. Anyw..."
"I love making spritz cookies. I am lucky enough to have inherited my mom's original copper and aluminum Mirro cookie press. I cherish it and make several different spritz recipes every year. My favorite shape has always been the wreath with a maraschino cherry half in the center. Seven year old DD & I made cookies galore today, and sh..."
"Delicious strawberry jam! This recipe is super easy, but I've just got to add another warning about using a big bowl. I used a 6-inch wide bowl that is about 4 inches deep. That was definitely not enough. Before I knew it there was strawberry syrup everywhere in the microwave. It smells delish, but was a huge mess. LOL I couldn't..."
"Just like my Swedish gramma used to make! I have always been partial to these cookies, but never make them for some reason. I will now though. They're really very easy. So easy in fact, that my 7 year old DD actually made them. The only thing I did was put in small dollops of jam and bake the pans. I used boysenberry jam and Pammy'..."
"I love me a good Spanish omelet, and this one did not let me down. I usually use cubes of ham, but now I know I prefer the flavor of the bacon. This was a quick and easy weeknight dinner after we all had busy days. The only thing I changed was to cut the raw bacon into small pieces, and then fry it. I just find it a lot less messy when I do it..."


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Fit Tips Softball (Adult):
Youth and Beginner: Gloves that are too big allow "cheating," preventing beginners from developing and refining proper skills. Kids' gloves should not be bought to be grown into. The best way to learn the fundamentals of fielding and catching is by wearing a glove that fits well Kids 12 and Under: No larger than 12 inches. Kids 8 and older should try gloves in the 11s, while younger kids (especially if they are smaller) should consider gloves in 9 to 11 inch range. Adolescent: Choose the lower end of the adult size range for your position. |


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THIS pitching staff wasn't THAT bad
Baseball October 9th, 2009
Why do I do this to myself? Why do I read anything on the JSOnline, anything written by Anthony Witrado or anything someone paid Anthony Witrado to do? Do I hate myself? I read Anthony Witrado's last chat of the season and was constantly pissed off while reading it. People asking if Corey Patterson would be our 2010 centerfielder, Witrado fellating Lopez, Witrado saying that Braun or Fielder would net Halladay and just, well, everything. It was all bad. The thing that pissed me off the most though, was this quote from A-dub.
No manager in the history of the game could have taken this team to the post-season with the way the starting pitching was built. Nobody. As any manager does, Macha has fair criticisms, but he almost deserves and INC for this season because the tools weren't in the shed to properly live up to expectations. You will never win by hitting, alone. You NEED to be able to pitch. Some things people don't like can be pinned on Macha, but not that.
Apparently the Brewers had the worst pitching in the history of baseball this season and had no chance to compete. Which is funny when you consider that on July 1st they were in first place.
Now, I'm not saying that the pitching was good. It wasn't, but it was good enough to have them competing for the division crown at the halfway point of the season. It was good enough for them to be among the frontrunners in the National League Central and National League Wild Card races. Unfortunately, there were a few things didn't go their way. Read the rest of this entry »


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Thousands march on Michigan Ave. in support of striking teachers
BY STEFANO ESPOSITO Staff Reporter September 11, 2012 2:30PM
- Union president here to support striking teachers
- Teachers strike below the belt with Nickelback sign
- Teachers picket Ald. Austin after comments about Lewis
- Brown: GOP candidates side with Emanuel on strike
- Marin: Emanuel picked fight with teachers
- Steinberg: Teachers walk out, so I step in ...
- Editorial: Teachers risk losing a lot if strike drags on
Article Extras
Related Stories
- Teachers strike enters its 3rd day with two sides 'kilometers apart'
- Video: Day 2 of teachers strike
- Frustration mounts for parents on second day of strike
- 47% of Chicago voters back teachers
- Map: Schools, churches, other sites open for students during strike
- Strike camps spring up around Chicago to give kids place to go
- Labor leaders supporting striking teachers invoke 9-11 terrorist attacks
- Can teachers strike over evaluations? 'Yes and no,' experts say
Updated: September 11, 2012 9:40PM
Thousands of Chicago teachers and their supporters marched in the Loop again Tuesday, closing down the southbound lanes of Michigan Avenue and other busy streets at rush hour as they made their way to Buckingham Fountain.
A crowd of about 2,000 gathered outside of Chicago Public School Headquarters, 125 S. Clark, and received plenty of support from passing motorists, many of whom are slowing down and honking their horns. As the afternoon wore on, thousands more joined the march as they made their way through downtown; the crowd stretched for blocks.
The teachers were upset over how the city diverts tax increment financing money from the schools to help some of the city's largest corporations, like the financial district downtown.
"Silly rich guy, Tifs are for kids!" one sign read. Another: "Tax Wall Street."
"Tired of getting the Rahm-around," another sign read.
Several teachers and other CPS staff said they couldn't make Monday's rally, so they were particularly energized Tuesday.
"I'm a newcomer," said Cynthia Lenow, a laid-off CPS payroll clerk. "I'm ready. I couldn't come out yesterday, but I couldn't let them down. ... I don't think this is going to wane. Our livelihood is on the line."
By 2:15 p.m., police began moving barricades to accommodate the crowd at the initial rally. Chanting, "Union Power!" CTU teachers and their supporters blocked the intersection at Clark and Adams.
The crowd, fired up by the presence of Chicago Teachers Union President Karen Lewis and American Federation of Teachers President Randi Weingarten, greeted the Lewis with cheers of "C-T-U!"
Lewis ventured into the crowd, waving, smiling and giving hugs. She was instantly surrounded by a swarm of red shirts.
The crowd then marched west on Adams and south on LaSalle, then past the Chicago Board of Trade chanting "Whose schools? Our schools!" before heading back north on Dearborn.
Throughout, protesters remained in a jubilant mood, obeying police orders to wait at intersections until cars have passed by.
Several teachers at the rally were asked about those parents and the rest of the public who may be losing patience with teachers.
"It's a no-win situation," said Christine Hauville, a music teacher at Jane Addams Elementary School. "I don't have children, so it's easy for me to come out here, but I have a lot of co-workers who have young kids. They have to make [child care] arrangements. So it's not easy
for anyone. I'd rather be teaching music."


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files released so far...
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Re: S-weekly for comment
Released on 2012-10-17 17:00 GMT
Email-ID | 1557170 |
Date | 2011-06-22 15:37:21 |
From | email@example.com |
To | firstname.lastname@example.com |
List-Name | email@example.com |
From: "Nate Hughes" <email@example.com>
To: "Analyst List" <email@example.com>
Sent: Wednesday, June 22, 2011 9:18:05 AM
Subject: S-weekly for comment
U.S. President Barack Obama <><announced June 22 that the the long process
of drawing down forces in Afghanistan> would begin, as expected and
scheduled, in July. [will refine the intro based on Obamaa**s speech Wed.]
Though the initial phase of the drawdown appears to be limited and the
tactical and operation impact on the ground will therefore be limited in
the immediate future, the United States and its allies are <><beginning
the inexorable process of drawing down their forces in Afghanistan>.
The Logistical Challenge
There are nearly 150,000 U.S. and allied troops in Afghanistan (Afghan
security forces now total about twice that). These forces appear
considerably a**lightera** than those in Iraq a** in Afghanistan, terrain
often dictates dismounted foot patrols and heavy main battle tanks and
self-propelled howitzers are few and far between (though not entirely
absent). Even a new, lighter and more agile version of <><the hulking
mine-resistant, ambush-protected vehicle known as the M-ATV> (for a**all
terrain vehiclea**) was required.
But this belies the fact that Afghanistan is a completely landlocked
country nestled up against the heart of Central Asia and one of the most
isolated countries on earth. Hundreds of shipping containers and fuel
trucks enter the country each and every day simply to sustain U.S. and
allied forces. It reportedly costs the U.S. military an average of US$400
to put a single gallon of gasoline in a vehicle or aircraft in
Afghanistan, and on the order of US$1 million a year to sustain a single
American soldier in the country (an Afghan soldier, by comparison, costs
about US$12,000 a year).
And construction continues. A new, 11,500-foot all-weather concrete and
asphalt runway and air traffic control tower were only completed this Feb.
at Camp Leatherneck and Camp Bastion in Helmand Province. Another over
9,000 foot runway was just finished at Shindand Airfield in Heart province
last Dec. Based solely on the activity on the ground in Afghanistan today,
one would think the United States and its allies were moving there
permanently, not preparing for the imminent beginning of a long-scheduled
<Picture a** iron mountain>
Meanwhile, an a**iron mountaina** of spare parts necessary to maintain
vehicles and aircraft, construction and engineering equipment, generators,
ammunition and other supplies a** even pallets upon pallets upon pallets
of bottled water a** has slowly been built up and continues to be
maintained in order to sustain day-to-day military operations. So while
there may be fewer troops in Afghanistan than Iraq at the peak of
operations there (some 170,000 U.S. troops all told at the height of the
Iraq surge) and in terms of tonnage of armored vehicles, the logistical
challenge of withdrawing from Afghanistan a** at whatever pace a** is
every bit as, if not more daunting than, the drawdown in Iraq and will
only be further complicated by the complexity of nearly 50 allies making
some troop contribution to the fight.
Furthermore, forces in Iraq had ready access to nearby and well
established military bases and modern port facilities in Kuwait a** as
well as to Turkey, a long-standing NATO ally. Though U.S. and allied
equipment comes ashore on a daily basis in the Pakistani port city of
Karachi, the facilities there are nothing like what exists in Kuwait at
this point. Routes to bases in Afghanistan are anything but short and
established, with locally-contracted fuel tankers and other supplies not
only traveling far greater distances, but regularly subject to harassing
attacks a** and inherently vulnerable to more aggressive interdiction by
militants fighting on terrain far more favorable to them (<><as well as
politically-motivated interruptions by Islamabad>). Most travel over the
isolated Khyber pass in the restive Pakistani Federally Administered
Tribal Areas west of Islamabad. In this case, the U.S. also has an
alternative to the north. But instead of Turkey, it has the Northern
Distribution Network (NDN), which runs through Central Asia and Russia
(which Moscow has agreed to continue to expand) and entails a XXXX mile
rail route to the Baltic Sea and the Latvian port of Riga.
Given the extraordinary distances involved, the metrics for defining
whether something is worth the expense of shipping back out of Afghanistan
are unforgiving. Some equipment will be deemed too heavily damaged or
cheap and will be sanitized and discarded. Much construction and
fortification has been done with engineering and construction equipment
like Hesco barriers that are filled with sand that will not be reclaimed.
Much equipment will be handed over to Afghan security forces (which have
already begun to receive up-armored U.S. HMMWVs -- a**humveesa**). Already
in Iraq, some 800,000 items valued at nearly US$100 million have been
handed over to over a dozen Iraqi security and government entities.
Other equipment will have to be stripped of sensitive equipment (radios
and other cryptographic gear, jammers for improvised explosive devices,
etc.), which is usually flown out of the country due to security concerns
before being shipped over land. And while some Iraq stocks were designated
for redeployment to Afghanistan or prepared for long-term storage in
prepositioned equipment depots and aboard maritime prepositioning ships at
facilities in Kuwait, most vehicles and supplies that are actually slated
to be moved out of Afghanistan will increasingly have to be shipped far
afield, whether by ship from Karachi or by ship or rail once it reaches
Europe, even if they are never intended to make the journey all the way
back to the United States.
But more important than the fate of armored trucks and equipment will be
the process of rebalancing forces across the country, handing over
outposts and facilities to Afghan security forces and scaling back the
extent of the U.S. and allied presence in the country. In Iraq, and likely
here in Afghanistan, the beginning of this process will be slow and
measured. But its pace in the years ahead remains to be seen and <><may
ultimately accelerate considerably>.
<><The first areas slated to be handed over to Afghan control> a** the
provinces of Panjshir, Bamian and Kabul (except the restive Surobi
district, though the rest of Kabula**s security effectively has been in
Afghan hands for years) and the cities of Mazar-e-Sharif, Herat, Lashkar
Gah and Mehtar Lam a** have been relatively quiet places for some time and
Afghan security forces are already increasingly in the lead in these
areas. As in Iraq, the first places to be turned over to indigenous
security forces are the ones that are already fairly secure. The trick
will be the more restive areas that are scheduled to be handed over later
in part because conditions are not yet deemed sufficient for any sort of
This process of pulling back and handing over responsibility for security
a** in Iraq, the term was often that Iraqi security forces were a**in the
leada** in specific areas a** is a slow and deliberate one, rather than
one sudden and jarring maneuver. Well before the formal announcement,
Afghan forces begin to transition to a more independent role, conducting
more small unit operations on their own. ISAF troops slowly transition
from joint patrols and tactical overwatch to a more operational overwatch
but remain in the area even after the transition has formally taken place.
Under the current training regime, Afghan units continue to require
advising and assistance, particularly with matters like intelligence,
planning, logistics and maintenance. So long as the President allows the
military to have a long leash, ISAF will be cautious in its reductions for
fear of pulling back too quickly and seeing the situation deteriorate a**
that is, unless they are directed to conduct a more hasty pull back.
The process of drawing down and handing over responsibility in each area
is something that was done very deliberately and cautiously in Iraq.
However, there is a critical distinction. <><The a**successa** of that
surge was facilitated by a political accommodation with the Sunni> that
<><has not (and cannot) be directly replicated in Afghanistan>. And even
with that advantage, Iraq today remains in an unsettled and contentious
state. <><The complete dearth of a political framework> to facilitate a
military pullback leaves the prospect of a viable transition in more
restive areas <><that have been the focus of efforts under the American
counterinsurgency-focused strategy> tenuous at best a** particularly if
timetables are accelerated.
In June 2009, U.S. Forces in Iraq occupied 357 bases. A year later, U.S.
Forces occupied only 92 bases, 58 of which were partnered with the Iraqis.
The pace of the transition in Afghanistan remains to be seen, but the
handing over of the majority of positions to Afghan forces will begin to
fundamentally alter the situational awareness, visibility and influence of
ISAF forces.
Casualties and Force Protection
A key consideration in crafting the drawdown and the scheme of maneuver
for pulling back to fewer, stronger and more secure positions as the
drawdown progresses will be the security of the remaining outposts and
ensuring the security of U.S. and allied forces and critical lines of
supply (particularly key sections of <><the Ring Road>) that both continue
to sustain remaining forces and will be essential to their eventual
retrograde from the country. As the drawdown progresses a** and
particularly if a more substantive shift in strategy is implemented a**
the increased pace begins to bring new incentives into play. Of particular
note will be both a military and political incentive to reduce casualties
as the endgame draws closer.
Balancing the desire to more rapidly consolidate to more secure positions
will grind against the need to pull back slowly and continue to provide
Afghan forces with advice and assistance. The reorientation itself may
expose potential vulnerabilities to Taliban attack in the process of
transitioning to a new posture, and major reversals and defeats for Afghan
security forces at the hands of the Taliban after they have been left to
their own devices will have repercussions far beyond the individual
locality of that defeat, and may begin to shift the psychology and
perception of the war in its own right.
When ISAF units are paired closely with Afghan forces, those units have a
stronger day-to-day tactical presence in the field, and other units are
generally operating nearby. So while they are more vulnerable and exposed
to threats like IEDs while out on patrol, they also a** indeed, in part
because of that exposure a** have a more alert and robust posture. As the
transition accelerates and particularly if it is accelerated by
Washington, the posture and therefore the vulnerabilities of forces
Force protection remains a key consideration throughout, and the U.S. in
particular gained considerable experience with that in the Iraq transition
a** though again, much of that transition was underlied by a political
accommodation that is lacking in Afghanistan.
As the drawdown continues, ISAF will have to balance having more troops in
the field alongside Afghan units and pulling more back to key strongholds
and removing more from the equation entirely by pulling them out of the
country completely. In the former case, the close presence of advisors can
help improve the effectiveness of Afghan security forces and also provides
better situational awareness. But it also exposes smaller units to
operations more distant from strongholds as the number of outposts and
major positions begins to be reduced.
In addition, as the process of pulling back accelerates and particularly
as allied forces increasingly hunker down on larger and more secure
outposts, their <><already limited situational awareness> will begin an
inexorable decline, which opens up its own vulnerabilities.
The Taliban
Ultimately, the Talibana**s incentive vis a vis the United States and its
allies is to survive, and even to conserve and maximize its strength for a
potential fight in the vacuum sure to ensue after the majority of foreign
troops have left the country. But at the same time, <><part of any
a**revolutionarya** movement is its ability to consolidate internal
control>, and the Taliban may also seek to take advantage of the shifting
tactical realities in order to demonstrate its strength and the extent of
its reach across the country by targeting not only newly independent and
newly isolated Afghan units but attempting to kill or even kidnap more
isolated foreign troops.
Though the Taliban has demonstrated this year that it can <><strike almost
anywhere in the country it chooses>, it has thus far failed to demonstrate
the ability to penetrate the perimeter of large, secured facilities with a
sizeable assault force. And with <><the intensity and tempo of special
operations forces raids on Taliban leadership and caches>, it is not
necessarily likely that the Taliban has been able to or hold back a
significant cache of more heavy arms and capability.
However, <><the inherent danger of compromise and penetration of
indigenous security forces> exists and continues to <><loom large>. And
the vulnerabilities of ISAF forces a** while they will begin to shift as
mission and posture change and evolve a** will persist while there remains
a presence in the country, particularly one thata**s disposition is
increasingly a residual presence and a legacy of a previous strategy. The
shift from a dispersed, counterinsurgency-focused orientation to a more
limited and more secure presence will be an improvement but it will
inherently entail more limited visibility and influence, so the space the
transition will create for more significant Taliban successes on the
battlefield cannot be ruled out.
Nathan Hughes
Military Analysis


text:
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Mercury Mountaineer Noises and Sounds
azamora1 Posts: 1
falkfam Posts: 2I hope someone can help me out. I am new and have never posted before. To start out I recently took off and cleaned the idle air control valve, because my car is making a horrible groaning/gurgling loud sound, and also intermidently idling ruff. I thought it helped at first but now the sound is worse than ever. I am going to order a new iac, and put it on for this problem. In the process of trying to get this fixed my car has started making a clanking/tapping sound in what seems to be the bottom area of the engine. Only when the AC is running. Not when just the blower is on, but the actual AC has to be on for the noise to start. It is constant, and loud. I got under the car and it sounds loudest at the bottom/back area of the engine. When I turn off the AC it stops. I still hear that groaning sound although it is much worse when the ac is on also. Could it be a pulley, or belt? Any ideas are greatly appreciated.
sclyatt Posts: 1My 2010 Mountaineer with 4k miles makes a low volume beeping noise while driving. The noise seems to come from the instrument cluster. The beeping has no regular rhythm to it. It stops when the vehicle stops or it may stop on its own. It never does it while sitting still. It makes no difference if the A/C, radio, or any other accessories are on or off at the time. It also does not do it every time I drive it. It started this beeping soon after I bought the car. I am at a loss as to what the cause of it is. Because it does not do it every time I drive, it makes it very difficult to have the dealer trouble shoot the problem. Anyone have any suggestions?
zanymom Posts: 3About a month ago my Mountaineer started making a clunking in the front when stopping; thought it might be something to do with the brakes; had it checked, got new front pads, rotors; still had the noise. It continued for a couple more weeks; then they replaced both front hub/bearing assemblies & both front lower ball joints & put brand new tires on it. Just got it back yesterday & it's still making the noise & it's even worse now? It seems to make it when going at slow slow speed so not when applying brakes and then when coming to a stop & after you stop you can hear it clunk like 3 times. It's a V6 2006 AWD with about 64,000 miles on it. Help, the noise drives me crazy & it feels like something is going to fall apart.
zanymom Posts: 3I don't think that is what it is; checked all under the hood; all looks tight & running well; sounds good too. It's almost more like a click click click click when slowing down & stopping vs a clunking. It's so hard to describe but I can hear it & it is driving me crazy & doesn't sound very good to me. It doesn't make any noises when turning the wheels back & forth or doesn't seem to be when braking just when slowing to slow speed & coming to a stop then when stopped it does it like 3 more times.
nvbanker Posts: 7,285By the way, visually inspecting your motor mounts with the hood up, means nothing. You have to have at least 2 people, one to watch the engine, and one to manage the brake and accelerator at the same time with it in gear, and look for the engine to move, and one to pull you out of the car after you run it through the garage door into the washing machine.
nvbanker Posts: 7,285The thing is, until it gets bad enough to identify, or manifests itself, nothing really can be done. So I tend to agree - drive it. It will get worse, or it won't. If it doesn't, no worries, if it does, you'll soon know what it is. Like a wheel bearing. Sometimes hard to identify, but eventually, you can.
I'm sorry, you'd think after 8 of 'em, I'd have seen everything, but this noise is a whole new problem for me! -
mellowyellow6 Posts: 1I have a 2006 Mercury Mountaineer. I recently had it in the shop for a noise in the front end that started once you hit 45 mph. It sounded like a bad hub. We had replaced several on our previous SUV, so we know what that noise means lol. The dealership replaced one of the hubs, I believe the passenger side. The noise is still there. It starts once you get up to 45 mph. I had my husband take it back. The mechanic said the hub is fine because it's tight, nothing is moving. He said Ford and Mercury SUVs are known for having noisey front ends. He said they eventually just get noisey, and there is nothing that can be done about it, because there really isn't a reason. I talked to another mechanic and he told me to take it back to the shop because it sounds lilke there is definitely something wrong and he's never heard of a vehicle having a noisey front end for no reason. Does anyone have any ideas? I haven't taken notice to if the sound changes or disappears when turning the wheel, and I can't drive it right now because it's at home, so unfortunately, I can't provide that information. :-(
Does anyone have any ideas? I would really like to get this taken care of! Thanks! :confuse:


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The transcoding process has 2 steps.I have been following the thread and I uninstalled and reinstalled. The problem I have been having is that I cannot download any new shows. I click download and it goes into a status called "waiting to prepare". I back out and click on my download queue and the download is under the heading "preparing for me". It will sit in that status for hours until I cancel the download. Nothing else is downloading. I don't know what it is "waiting" for? I have used the nomad on my IPad for 9 months with no issues until last week. Anyone else have the same issue or have suggestions on what to do?
The first is preparing...which generally takes about the same time as the program length - a 2 hour show takes about 2 hours to do the prepare step, so most people don't sit and watch it process.
The second step is the download - which takes about 11 minutes or so for the same 2 hours show.
Both steps must complete to have the transcoded program transferred to a mobile device, no matter what kind of device it is.


text:
Dragonforce - Opera House, Toronto - October 20th, 2011
Review and Photos by Mike Bax
I'm sure everyone in attendance for this performance had one underlying question on their minds before Dragonforce took the stage to a crowd of about 700 fans - and that was, "How will the band sound with new vocalist Marc Hudson". The answer to that question was a very easy "Just fine thank you very much!" even WITH the nasty viral throat infection Hudson has been wrestling for days. This evening's show was supposed to be the second of three small club 'preview' shows to introduce Marc to North American Dragonforce audiences, and I can't image his frustration over having to cancel the first of these shows in L.A. two nights before the band's Toronto appearance.
Because of this L.A. cancellation, what Toronto wound up getting was the very first North American appearance of Dragonforce with their new vocalist in place. Even with his self-admitted problematic vocals this evening, the eight songs performed all sounded tip-top, and Hudson makes an almost seamless fit with the band, stepping into the shoes left vacant by ex-vocalist ZP Theart almost two years ago.
Eight songs might sound like a very short set of material, but if you factor in the average running time of a Dragonforce song at seven to ten minutes in length, the band delivered a decent show. I understand that a song may have been dropped off their originally planned performance, but with Hudson as sick as he was, I think we'll just be glad that the band could even play and leave it at that.
The downside of playing such a small venue for Dragonforce was that they only 'just' fit on the stage. Six gentlemen playing some of the fastest power metal on the planet on a stage the size of the Opera House doesn't come without a few compromises. The band's trampolines and some of their standard backdrop and lighting had to sit out the show. The upside was seeing the band perform in a venue this small again. The last time they rolled through Toronto, it was a Sound Academy performance and the hall was close to packed. I felt like this evening was a rare opportunity to get to see them play up close and personal.
Keyboardist Vadim Pruzhanov, now almost shaved completely bald (a small swatch of hair centered atop his head reminded me of a Dr Seuss character), bounced about the back left of the stage in such wild abandon, it's surprising he can play live as keenly as he does. Herman Li and Sam Totman unleashed a behemoth-sized hour of epic live guitar riffs while drummer Dave Mackintosh and bassist Frederic Leclercq bashed out the lighting fast backbone beats on their respective instruments.
Marc Hudson thanked everyone for coming out a few times throughout the evening and easily put to rest any worries about the future of the band and their vocal presence. He pushed out vocals to old tracks like 'Heroes of Our Time' and 'Through the Fire and Flames' with as much confidence as the two new tracks ('Cry Thunder' and 'Lost Fallen World') performed.
Though I've yet to hear a single studio song from their upcoming fifth album, I left the concert convinced of two things: Marc Hudson is a good fit for Dragonforce, and the new material promises to be quite interesting. 'Lost Fallen World' carries a relentless guitar riff throughout the song and the lyrics sound totally majestic. Watch for it in early 2012.
Set list:
Heroes of Our Time
Operation Ground and Pound
Cry Thunder
Lost Fallen World
The Last Journey Home
Fury of the Storm
Through the Fire and Flames
As far as I know the name of
As far as I know the name of the song is "Last Fallen World", not "Lost Forgotten World"


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Lionel Railroad Club inspires daydreams among young and old
By Janet Lundquist firstname.lastname@example.com November 25, 2012 7:20PM
Herbert Koch, president of the Chicagoland Lionel Railroad Club, controls two trains while overlooking their setup at the Lionel Railroad Club Open House in New Lenox, Illinois, Saturday, Nov. 17, 2012. | Karen Gioia ~ For Sun-Times Media
Article Extras
Updated: December 27, 2012 6:14AM
The scene at the Chicagoland Lionel Railroad Club was pure nostalgia.
The holiday lights were on, decorated trees were up and toy trains were chugging through it all.
Herb Koch, a founding member of the club, said it was Christmas 1956 when he and his brother got their first train set.
Koch's father set up the train to run as they walked into the room, and Koch's lifelong love of trains was born.
The club, headquartered in a New Lenox industrial park, recently opened its doors to the public so others could indulge in a little way-back daydreaming. The club hosted an open house that served as a prequel to its December holiday open houses that traditionally draw big crowds.
The club has been around for almost 20 years and has grown to more than 100 members — most of whom have set up train stuff at the clubhouse as well as in their family rooms or basements at home. Members host public open houses at their clubhouse each month.
"You're never too old to be a kid," member Bob Ciolino, of Frankfort, said.
Even without that iconic Christmas image emblazoned in one's memory — like Koch, of Palos Park — the visuals and sheer coordination required to run trains through the exhibition is intriguing.
Or, if electronics or engineering is your thing, the club can feed that interest, too.
Some club members specialize in fixing Lionel train parts, and some have the knowledge to ensure the trains run smoothly without derailing or colliding.
"If you have trains at home, you always have somebody here who will know how to handle it," said Joe Oster of Frankfort. "It's an avenue for people who, maybe their father left them a train but they don't know how to fix it."
Young and old wandered around the giant O Gauge modular layout, crouching to study the detail of the scenery, waving away the smoke curling from the tiny engines as they chugged around the room.
"It's never too late to have a happy childhood," club member Kevin Barry, of Chicago, said. "I'm 62 and I still play with trains."
Scott Prihar, of Manhattan, stood by as his 5-year-old son, Ryland, hurried along the layout carrying a stepstool — the club keeps a stack of them near the door for kids like Ryland. The boy set it up at various points along the edge of the table and stood on it, silently watching with wide eyes.
"We come to all the open houses," Prihar said, adding they've been regulars at the clubhouse for about three years. "He loves trains."
An actual train inspired Angela Reed's hobby.
Reed, of Frankfort, vividly recalls a childhood memory of riding in a steam engine with her father in her native New Zealand, feeling the heat and hearing the roar of the fire as the firemen fed the engine.
Now, she focuses on detailed scenery to surround her trains. Her handiwork — natural surroundings such as mountains, rocks and trees, as well as buildings, fences and people — is on display at the clubhouse, where she creates to her heart's content.
"I love it," she said, mentioning her painstakingly-tweaked family room train display. "My mother was a commercial artist, she was very artistic."
The club will host its Winter Wonderland Christmas open houses Saturday and Dec. 8, which will also include photos with Santa. The clubhouse will be open to the public from 9 a.m. to 3 p.m. those days.
The club has a space large enough to fit a huge layout capable of running trains 142 cars long on 143-foot-long mainlines. Visitors are able to operate more than 30 interactive features — such as cars pulling into miniature gas stations and paperboys flinging newspapers — with the push of a button.
Admission is free for members, $2 per nonmember or $5 per family. Free popcorn will be available, and hot dogs, pizza and pop will be sold.
Visitors also may bring trains in for repairs, as the CLRC is an authorized Lionel service station, Koch said.
For more information or directions, visit www.clrctrains.com.


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New for 2014! The lightweight and versatile NEMO Switch 1P tent can serve as a solo backpacking ground shelter, a bug net on safari or even as a protected sleeping enclosure on top of a cot (not included).
New for 2014! With its roomy interior, 2 large doors and good ventilation, the NEMO Galaxi 2P tent is a durable, lightweight 3-season shelter with a great feature set for first-time and budget-minded backpackers. NEMO even throws in a free footprint.
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Sleek, compact offerings designed for the solo backpacker or camper
Tents with room for two or extra roominess for one
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As a minor note to what you've written, apparently the 2010 Mitsubishi DLPs that support the SbS 3D format are not "fully capable of decoding the DTV DVR 3D format", since they still require the external Mitsubishi adapter. Some such solution as the one you discuss could solve this problem, as well.
Actually the 2010 Mitsubishi DLPs do not need the adapter to decode the DVR SbS 3D format. DTV did not add them to the "White List" so they require the adaptor just to provide an acceptable EDID. But like I said in my post this is probably a separate issue to what we are trying to resolve here..


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WholeFoods Magazine SourceBook: The Natural Products Directory
A new study published in the gastroenterology and hepatology journal Gut indicates that curcumin may be a viable option for slowing down liver damage and cirrhosis.
SunRidge Farms, maker of natural and organic dried fruit, nuts, seeds, candies, and trail and snack mixes, has a new green initiative.
Promotions, new hires, retirements and more.
Acquisitions, company news, web site launches and more.
Research reveals that shoppers with fewer choices buy more stuff.
What's hot on the restaurant scene are big, bold flavors, which increasingly means crossing paths with the food police's latest bandit: sodium.
News from industry suppliers.
The American Herbal Products Association (AHPA) now offers more than 50 modifiable templates for manufacturing standard operating procedures.
The April issue of Archives of Ophthalmology included some interesting research in which patients with retinitis pigmentosa benefited greatly from lutein and vitamin A supplementation.
Looking great entails stripping down to build back up....
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Foot Acupuncture Model
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Size: 15cm.
Weight (including packaging): 300g
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Kirsten Dunst through the years
Published On: Apr 25 2012 03:05:16 PM CDT
Updated On: Sep 24 2014 09:39:11 AM CDT
As Kirsten Dunst plays in "The Two Faces of January," take a minute to reflect on the actress' career so far.
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